> top > docs > PMC:3062687 > spans > 15797-18514 > annotations

PMC:3062687 / 15797-18514 JSONTXT

Annnotations TAB JSON ListView MergeView

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T12387 0-5 P23396 denotes NleH1
T12388 15-19 P23396 denotes RPS3
T12389 351-356 P23396 denotes NleH1
T12390 381-385 P23396 denotes RPS3
T12391 424-428 P23396 denotes RPS3
T12392 488-493 P23396 denotes NleH1
T12393 521-525 P23396 denotes RPS3
T12394 596-601 P23396 denotes NleH1
T12395 704-709 P23396 denotes NleH1
T12396 723-726 P01375 denotes TNF
T12397 753-757 P23396 denotes RPS3
T12398 830-835 P23396 denotes NleH1
T12399 867-870 P01375 denotes TNF
T12400 897-901 P25963 denotes IκBα
T12401 943-948 P23396 denotes NleH1
T12402 959-962 P21579 denotes p65
T12403 959-962 Q04206 denotes p65
T12404 1013-1018 P23396 denotes NleH1
T12405 1028-1032 P23396 denotes RPS3
T12406 1131-1136 P23396 denotes nleH1
T12407 1138-1144 P23396 denotes ΔnleH1
T12408 1206-1211 P23396 denotes NleH1
T12409 1234-1239 Q7DB71 denotes ΔescN
T12410 1263-1266 P01375 denotes TNF
T12411 1310-1314 P23396 denotes RPS3
T12412 1383-1387 P23396 denotes RPS3
T12413 1505-1508 P01375 denotes TNF
T12414 1517-1521 P23396 denotes RPS3
T12415 1588-1594 P23396 denotes ΔnleH1
T12416 1598-1603 Q7DB71 denotes ΔescN
T12417 1660-1666 P23396 denotes ΔnleH1
T12418 1670-1675 Q7DB71 denotes ΔescN
T12419 1717-1720 P01375 denotes TNF
T12420 1729-1733 P23396 denotes RPS3
T12421 1779-1783 P23396 denotes RPS3
T12422 1931-1935 P23396 denotes RPS3
T12423 2016-2021 P23396 denotes NleH1
T12424 2031-2035 P23396 denotes RPS3
T12425 2094-2098 P23396 denotes RPS3
T12426 2147-2150 P10145 denotes IL8
T12427 2152-2158 P25963 denotes NFKBIA
T12428 2164-2171 P21580 denotes TNFAIP3
T12429 2331-2337 P23396 denotes ΔnleH1
T12430 2341-2346 Q7DB71 denotes ΔescN
T12431 2388-2393 P23396 denotes nleH1
T12432 2429-2433 P23396 denotes RPS3
T12433 2463-2467 P01589 denotes CD25
T12434 2546-2551 P23396 denotes NleH1
T12435 2626-2630 P23396 denotes RPS3
T12436 2683-2687 P23396 denotes RPS3

2_test

Id Subject Object Predicate Lexical cue
21399639-8852900-74765167 144-146 8852900 denotes 31
21399639-8852900-74765167 144-146 8852900 denotes 31
21399639-20041225-74765168 297-298 20041225 denotes 9
21399639-20041225-74765168 297-298 20041225 denotes 9
21399639-20126447-74765169 300-302 20126447 denotes 33
21399639-20126447-74765169 300-302 20126447 denotes 33
21399639-20485572-74765169 300-302 20485572 denotes 33
21399639-20485572-74765169 300-302 20485572 denotes 33
21399639-21091507-74765169 300-302 21091507 denotes 33
21399639-21091507-74765169 300-302 21091507 denotes 33
21399639-21113130-74765169 300-302 21113130 denotes 33
21399639-21113130-74765169 300-302 21113130 denotes 33
21399639-20833837-74765169 300-302 20833837 denotes 33
21399639-20833837-74765169 300-302 20833837 denotes 33
21399639-21187904-74765169 300-302 21187904 denotes 33
21399639-21187904-74765169 300-302 21187904 denotes 33
21399639-20041225-74765170 454-455 20041225 denotes 9
21399639-20041225-74765170 454-455 20041225 denotes 9
21399639-20041225-74765171 689-690 20041225 denotes 9
21399639-20041225-74765171 689-690 20041225 denotes 9
21399639-20041225-74765172 984-985 20041225 denotes 9
21399639-20041225-74765172 984-985 20041225 denotes 9
21399639-20041225-74765173 1755-1756 20041225 denotes 9
21399639-20041225-74765173 1755-1756 20041225 denotes 9

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T11955 0-5 NN denotes NleH1
T11956 6-14 VB denotes inhibits
T11957 15-19 NN denotes RPS3
T11958 20-35 NN denotes phosphorylation
T11959 36-38 FW denotes in
T11960 39-44 FW denotes vitro
T11961 45-49 NN denotes EHEC
T11962 50-59 NN denotes pathogens
T11963 60-63 VB denotes are
T11964 64-73 JJ denotes important
T11965 74-83 JJ denotes causative
T11966 84-90 NN denotes agents
T11967 91-93 IN denotes of
T11968 94-98 CC denotes both
T11969 99-108 JJ denotes foodborne
T11970 109-116 NN denotes disease
T11971 117-120 CC denotes and
T11972 121-130 JJ denotes pediatric
T11973 131-136 JJ denotes renal
T11974 137-146 NN denotes failure31
T11975 148-152 NN denotes EHEC
T11976 153-160 VB denotes utilize
T11977 161-165 NN denotes T3SS
T11978 166-168 TO denotes to
T11979 169-175 VB denotes inject
T11980 176-184 NN denotes effector
T11981 185-193 NN denotes proteins
T11982 194-202 RB denotes directly
T11983 203-207 IN denotes into
T11984 208-218 JJ denotes intestinal
T11985 219-229 JJ denotes epithelial
T11986 230-237 NN denotes cells32
T11987 237-238 -COMMA- denotes ,
T11988 239-240 DT denotes a
T11989 241-247 NN denotes subset
T11990 248-250 IN denotes of
T11991 251-256 WDT denotes which
T11992 257-264 VB denotes inhibit
T11993 265-280 JJ denotes NF-κB-dependent
T11994 281-287 JJ denotes innate
T11995 288-298 NN denotes responses9
T11996 298-299 -COMMA- denotes ,
T11997 300-305 CD denotes 33-38
T11998 307-310 DT denotes The
T11999 311-313 FW denotes E.
T12000 314-318 FW denotes coli
T12001 319-323 NN denotes O157
T12002 323-324 -COLON- denotes :
T12003 324-326 NN denotes H7
T12004 327-333 NN denotes EDL933
T12005 334-342 NN denotes effector
T12006 343-350 NN denotes protein
T12007 351-356 NN denotes NleH1
T12008 357-362 VB denotes binds
T12009 363-365 TO denotes to
T12010 366-369 CC denotes and
T12011 370-380 VB denotes attenuates
T12012 381-385 NN denotes RPS3
T12013 386-393 JJ denotes nuclear
T12014 394-407 NN denotes translocation
T12015 407-408 -COMMA- denotes ,
T12016 409-413 RB denotes thus
T12017 414-423 VB denotes impairing
T12018 424-438 JJ denotes RPS3-dependent
T12019 439-444 NN denotes NF-κB
T12020 445-455 NN denotes signaling9
T12021 457-459 PRP denotes We
T12022 460-469 RB denotes therefore
T12023 470-482 VB denotes hypothesized
T12024 483-487 IN denotes that
T12025 488-493 NN denotes NleH1
T12026 494-497 MD denotes may
T12027 498-506 VB denotes function
T12028 507-509 IN denotes by
T12029 510-520 VB denotes inhibiting
T12030 521-525 NN denotes RPS3
T12031 526-530 NN denotes S209
T12032 531-546 NN denotes phosphorylation
T12033 548-550 IN denotes As
T12034 551-559 VB denotes expected
T12035 559-560 -COMMA- denotes ,
T12036 561-573 VB denotes transfecting
T12037 574-584 VB denotes increasing
T12038 585-592 NN denotes amounts
T12039 593-595 IN denotes of
T12040 596-604 NN denotes NleH1-HA
T12041 605-612 NN denotes plasmid
T12042 613-620 VB denotes blocked
T12043 621-633 JJ denotes TNFα-induced
T12044 634-639 NN denotes NF-κB
T12045 640-650 NN denotes activation
T12046 651-653 IN denotes in
T12047 654-655 DT denotes a
T12048 656-670 JJ denotes dose-dependent
T12049 671-677 NN denotes manner
T12050 678-679 -LRB- denotes (
T12051 679-683 NNP denotes Fig.
T12052 684-688 CD denotes 6a-b
T12053 688-689 -RRB- denotes )
T12054 689-690 CD denotes 9
T12055 692-702 RB denotes Remarkably
T12056 702-703 -COMMA- denotes ,
T12057 704-709 NN denotes NleH1
T12058 710-717 VB denotes reduced
T12059 718-722 CC denotes both
T12060 723-734 JJ denotes TNF-induced
T12061 734-735 -COMMA- denotes ,
T12062 736-738 RB denotes as
T12063 739-743 RB denotes well
T12064 744-746 IN denotes as
T12065 747-752 JJ denotes basal
T12066 753-757 NN denotes RPS3
T12067 758-773 NN denotes phosphorylation
T12068 774-776 TO denotes to
T12069 777-784 RB denotes roughly
T12070 785-787 CD denotes 20
T12071 787-788 NN denotes %
T12072 789-791 IN denotes of
T12073 792-799 NN denotes vehicle
T12074 800-807 NN denotes control
T12075 808-809 -LRB- denotes (
T12076 809-813 NNP denotes Fig.
T12077 814-816 NN denotes 6c
T12078 816-817 -RRB- denotes )
T12079 819-829 VB denotes Expressing
T12080 830-835 NN denotes NleH1
T12081 836-840 VB denotes does
T12082 841-844 RB denotes not
T12083 845-854 VB denotes interfere
T12084 855-859 IN denotes with
T12085 860-866 CC denotes either
T12086 867-878 JJ denotes TNF-induced
T12087 879-882 NN denotes IKK
T12088 883-893 NN denotes activation
T12089 894-896 CC denotes or
T12090 897-901 NN denotes IκBα
T12091 902-913 NN denotes degradation
T12092 913-914 -COMMA- denotes ,
T12093 915-925 JJ denotes consistent
T12094 926-930 IN denotes with
T12095 931-934 DT denotes the
T12096 935-939 NN denotes lack
T12097 940-942 IN denotes of
T12098 943-948 NN denotes NleH1
T12099 949-955 NN denotes impact
T12100 956-958 IN denotes on
T12101 959-962 NN denotes p65
T12102 963-970 JJ denotes nuclear
T12103 971-985 NN denotes translocation9
T12104 986-987 -LRB- denotes (
T12105 987-991 NN denotes Fig.
T12106 992-994 NN denotes 6c
T12107 994-995 -RRB- denotes )
T12108 997-999 TO denotes To
T12109 1000-1009 VB denotes determine
T12110 1010-1012 IN denotes if
T12111 1013-1018 NN denotes NleH1
T12112 1019-1027 VB denotes inhibits
T12113 1028-1032 NN denotes RPS3
T12114 1033-1048 NN denotes phosphorylation
T12115 1048-1049 -COMMA- denotes ,
T12116 1050-1052 PRP denotes we
T12117 1053-1061 VB denotes infected
T12118 1062-1066 NN denotes HeLa
T12119 1067-1072 NN denotes cells
T12120 1073-1077 IN denotes with
T12121 1078-1080 FW denotes E.
T12122 1081-1085 FW denotes coli
T12123 1086-1090 NN denotes O157
T12124 1090-1091 -COLON- denotes :
T12125 1091-1093 NN denotes H7
T12126 1094-1101 NN denotes strains
T12127 1102-1112 VB denotes possessing
T12128 1113-1115 CC denotes or
T12129 1116-1123 VB denotes lacking
T12130 1124-1130 CC denotes either
T12131 1131-1136 NN denotes nleH1
T12132 1137-1138 -LRB- denotes (
T12133 1138-1144 NN denotes ΔnleH1
T12134 1144-1145 -RRB- denotes )
T12135 1146-1148 CC denotes or
T12136 1149-1153 IN denotes with
T12137 1154-1155 DT denotes a
T12138 1156-1162 NN denotes strain
T12139 1163-1170 VB denotes lacking
T12140 1171-1172 DT denotes a
T12141 1173-1183 JJ denotes functional
T12142 1184-1188 NN denotes T3SS
T12143 1189-1195 JJ denotes unable
T12144 1196-1198 TO denotes to
T12145 1199-1205 VB denotes inject
T12146 1206-1211 NN denotes NleH1
T12147 1212-1216 IN denotes into
T12148 1217-1226 JJ denotes mammalian
T12149 1227-1232 NN denotes cells
T12150 1233-1234 -LRB- denotes (
T12151 1234-1239 NN denotes ΔescN
T12152 1239-1240 -RRB- denotes )
T12153 1242-1244 IN denotes In
T12154 1245-1255 JJ denotes uninfected
T12155 1256-1261 NN denotes cells
T12156 1261-1262 -COMMA- denotes ,
T12157 1263-1276 NN denotes TNF-treatment
T12158 1277-1287 VB denotes stimulated
T12159 1288-1289 DT denotes a
T12160 1290-1297 JJ denotes ∼7-fold
T12161 1298-1306 NN denotes increase
T12162 1307-1309 IN denotes in
T12163 1310-1314 NN denotes RPS3
T12164 1315-1319 NN denotes S209
T12165 1320-1335 NN denotes phosphorylation
T12166 1335-1336 -COMMA- denotes ,
T12167 1337-1344 VB denotes peaking
T12168 1345-1347 IN denotes at
T12169 1348-1350 CD denotes 30
T12170 1351-1358 NN denotes minutes
T12171 1359-1360 -LRB- denotes (
T12172 1360-1364 NNP denotes Fig.
T12173 1365-1367 CD denotes 6d
T12174 1367-1368 -RRB- denotes )
T12175 1370-1372 IN denotes By
T12176 1373-1381 NN denotes contrast
T12177 1381-1382 -COMMA- denotes ,
T12178 1383-1387 NN denotes RPS3
T12179 1388-1392 NN denotes S209
T12180 1393-1408 NN denotes phosphorylation
T12181 1409-1412 VB denotes was
T12182 1413-1426 RB denotes substantially
T12183 1427-1435 JJ denotes impaired
T12184 1436-1438 IN denotes in
T12185 1439-1444 NN denotes cells
T12186 1445-1453 VB denotes infected
T12187 1454-1458 IN denotes with
T12188 1459-1468 JJ denotes wild-type
T12189 1469-1471 FW denotes E.
T12190 1472-1476 FW denotes coli
T12191 1477-1481 NN denotes O157
T12192 1481-1482 -COLON- denotes :
T12193 1482-1484 NN denotes H7
T12194 1485-1486 -LRB- denotes (
T12195 1486-1490 NNP denotes Fig.
T12196 1491-1493 CD denotes 6d
T12197 1493-1494 -RRB- denotes )
T12198 1496-1503 RB denotes However
T12199 1503-1504 -COMMA- denotes ,
T12200 1505-1516 JJ denotes TNF-induced
T12201 1517-1521 NN denotes RPS3
T12202 1522-1526 NN denotes S209
T12203 1527-1542 NN denotes phosphorylation
T12204 1543-1546 VB denotes was
T12205 1547-1557 JJ denotes unimpaired
T12206 1558-1560 IN denotes in
T12207 1561-1566 NN denotes cells
T12208 1567-1575 VB denotes infected
T12209 1576-1580 IN denotes with
T12210 1581-1587 CC denotes either
T12211 1588-1594 NN denotes ΔnleH1
T12212 1595-1597 CC denotes or
T12213 1598-1603 NN denotes ΔescN
T12214 1604-1605 -LRB- denotes (
T12215 1605-1609 NNP denotes Fig.
T12216 1610-1612 CD denotes 6d
T12217 1612-1613 -RRB- denotes )
T12218 1615-1617 PRP denotes We
T12219 1618-1624 VB denotes showed
T12220 1625-1635 RB denotes previously
T12221 1636-1640 IN denotes that
T12222 1641-1650 JJ denotes wild-type
T12223 1650-1651 -COMMA- denotes ,
T12224 1652-1655 CC denotes but
T12225 1656-1659 RB denotes not
T12226 1660-1666 NN denotes ΔnleH1
T12227 1667-1669 CC denotes or
T12228 1670-1675 FW denotes ΔescN
T12229 1676-1678 FW denotes E.
T12230 1679-1683 FW denotes coli
T12231 1684-1688 NN denotes O157
T12232 1688-1689 -COLON- denotes :
T12233 1689-1691 NN denotes H7
T12234 1692-1705 RB denotes significantly
T12235 1706-1716 VB denotes attenuated
T12236 1717-1728 JJ denotes TNF-induced
T12237 1729-1733 NN denotes RPS3
T12238 1734-1741 JJ denotes nuclear
T12239 1742-1756 NN denotes translocation9
T12240 1758-1761 DT denotes The
T12241 1762-1770 NN denotes parallel
T12242 1771-1778 IN denotes between
T12243 1779-1783 NN denotes RPS3
T12244 1784-1799 NN denotes phosphorylation
T12245 1800-1803 CC denotes and
T12246 1804-1807 PRP-DOLLAR- denotes its
T12247 1808-1815 JJ denotes nuclear
T12248 1816-1829 NN denotes translocation
T12249 1830-1836 IN denotes during
T12250 1837-1839 FW denotes E.
T12251 1840-1844 FW denotes coli
T12252 1845-1854 NN denotes infection
T12253 1855-1863 VB denotes provides
T12254 1864-1872 NN denotes evidence
T12255 1873-1875 IN denotes in
T12256 1876-1879 DT denotes the
T12257 1880-1887 NN denotes context
T12258 1888-1890 IN denotes of
T12259 1891-1893 DT denotes an
T12260 1894-1909 JJ denotes NF-κB-dependent
T12261 1910-1917 NN denotes disease
T12262 1918-1925 NN denotes process
T12263 1926-1930 IN denotes that
T12264 1931-1935 NN denotes RPS3
T12265 1936-1940 NN denotes S209
T12266 1941-1956 NN denotes phosphorylation
T12267 1957-1959 VB denotes is
T12268 1960-1969 JJ denotes important
T12269 1970-1973 IN denotes for
T12270 1974-1981 JJ denotes nuclear
T12271 1982-1995 NN denotes translocation
T12272 1997-2000 PRP-DOLLAR- denotes Our
T12273 2001-2010 NN denotes discovery
T12274 2011-2015 IN denotes that
T12275 2016-2021 NN denotes NleH1
T12276 2022-2030 VB denotes inhibits
T12277 2031-2035 NN denotes RPS3
T12278 2036-2040 NN denotes S209
T12279 2041-2056 NN denotes phosphorylation
T12280 2057-2066 VB denotes suggested
T12281 2067-2071 IN denotes that
T12282 2072-2074 PRP denotes it
T12283 2075-2081 MD denotes should
T12284 2082-2086 RB denotes also
T12285 2087-2093 VB denotes blocks
T12286 2094-2108 JJ denotes RPS3-dependent
T12287 2109-2114 NN denotes NF-κB
T12288 2115-2121 NN denotes target
T12289 2122-2126 NN denotes gene
T12290 2127-2140 NN denotes transcription
T12291 2141-2142 -LRB- denotes (
T12292 2142-2146 FW denotes e.g.
T12293 2147-2150 NN denotes IL8
T12294 2150-2151 -COMMA- denotes ,
T12295 2152-2158 NN denotes NFKBIA
T12296 2158-2159 -COMMA- denotes ,
T12297 2160-2163 CC denotes and
T12298 2164-2171 NN denotes TNFAIP3
T12299 2171-2172 -RRB- denotes )
T12300 2174-2180 RB denotes Indeed
T12301 2180-2181 -COMMA- denotes ,
T12302 2182-2187 DT denotes these
T12303 2188-2193 NN denotes genes
T12304 2194-2198 VB denotes were
T12305 2199-2203 RB denotes only
T12306 2204-2212 RB denotes modestly
T12307 2213-2224 VB denotes upregulated
T12308 2225-2227 IN denotes in
T12309 2228-2233 NN denotes cells
T12310 2234-2242 VB denotes infected
T12311 2243-2247 IN denotes with
T12312 2248-2257 JJ denotes wild-type
T12313 2258-2260 FW denotes E.
T12314 2261-2265 FW denotes coli
T12315 2266-2270 NN denotes O157
T12316 2270-2271 -COLON- denotes :
T12317 2271-2273 NN denotes H7
T12318 2273-2274 -COMMA- denotes ,
T12319 2275-2278 CC denotes but
T12320 2279-2292 RB denotes significantly
T12321 2293-2300 VB denotes induced
T12322 2301-2303 IN denotes in
T12323 2304-2309 NN denotes cells
T12324 2310-2318 VB denotes infected
T12325 2319-2323 IN denotes with
T12326 2324-2330 CC denotes either
T12327 2331-2337 NN denotes ΔnleH1
T12328 2338-2340 CC denotes or
T12329 2341-2346 NN denotes ΔescN
T12330 2347-2354 NN denotes strains
T12331 2355-2356 -LRB- denotes (
T12332 2356-2360 NNP denotes Fig.
T12333 2361-2363 NNP denotes 6e
T12334 2363-2364 -RRB- denotes )
T12335 2366-2368 IN denotes In
T12336 2369-2377 NN denotes contrast
T12337 2377-2378 -COMMA- denotes ,
T12338 2379-2387 VB denotes deleting
T12339 2388-2393 NN denotes nleH1
T12340 2394-2397 VB denotes had
T12341 2398-2400 DT denotes no
T12342 2401-2407 NN denotes impact
T12343 2408-2410 IN denotes on
T12344 2411-2414 DT denotes the
T12345 2415-2425 NN denotes expression
T12346 2426-2428 IN denotes of
T12347 2429-2445 JJ denotes RPS3-independent
T12348 2446-2451 NN denotes genes
T12349 2451-2452 -COMMA- denotes ,
T12350 2453-2462 VB denotes including
T12351 2463-2467 NN denotes CD25
T12352 2468-2471 CC denotes and
T12353 2472-2480 NN denotes TNFSF13B
T12354 2481-2482 -LRB- denotes (
T12355 2482-2495 NNP denotes Supplementary
T12356 2496-2500 NNP denotes Fig.
T12357 2501-2503 CD denotes 12
T12358 2503-2504 -RRB- denotes )
T12359 2506-2514 RB denotes Together
T12360 2515-2520 DT denotes these
T12361 2521-2528 NN denotes results
T12362 2529-2540 VB denotes demonstrate
T12363 2541-2545 IN denotes that
T12364 2546-2551 NN denotes NleH1
T12365 2552-2564 RB denotes specifically
T12366 2565-2573 VB denotes inhibits
T12367 2574-2577 DT denotes the
T12368 2578-2588 JJ denotes protective
T12369 2589-2595 JJ denotes immune
T12370 2596-2604 NN denotes response
T12371 2605-2607 IN denotes by
T12372 2608-2616 RB denotes directly
T12373 2617-2625 VB denotes blocking
T12374 2626-2630 NN denotes RPS3
T12375 2631-2635 NN denotes S209
T12376 2636-2651 NN denotes phosphorylation
T12377 2652-2655 CC denotes and
T12378 2656-2663 RB denotes thereby
T12379 2664-2673 VB denotes impairing
T12380 2674-2682 JJ denotes critical
T12381 2683-2697 JJ denotes RPS3-dependent
T12382 2698-2703 NN denotes NF-κB
T12383 2704-2710 NN denotes target
T12384 2711-2716 NN denotes genes
R9582 T11955 T11956 arg1Of NleH1,inhibits
R9583 T11956 T11960 arg1Of inhibits,vitro
R9584 T11958 T11956 arg2Of phosphorylation,inhibits
R9585 T11958 T11957 arg1Of phosphorylation,RPS3
R9586 T11960 T11959 arg1Of vitro,in
R9587 T11962 T11961 arg1Of pathogens,EHEC
R9588 T11962 T11963 arg1Of pathogens,are
R9589 T11966 T11963 arg2Of agents,are
R9590 T11966 T11964 arg1Of agents,important
R9591 T11966 T11965 arg1Of agents,causative
R9592 T11966 T11967 arg1Of agents,of
R9593 T11970 T11969 arg1Of disease,foodborne
R9594 T11970 T11971 arg1Of disease,and
R9595 T11971 T11967 arg2Of and,of
R9596 T11971 T11968 arg1Of and,both
R9597 T11974 T11971 arg2Of failure31,and
R9598 T11974 T11972 arg1Of failure31,pediatric
R9599 T11974 T11973 arg1Of failure31,renal
R9600 T11975 T11976 arg1Of EHEC,utilize
R9601 T11977 T11976 arg2Of T3SS,utilize
R9602 T11977 T11978 modOf T3SS,to
R9603 T11979 T11978 arg1Of inject,to
R9604 T11979 T11982 arg1Of inject,directly
R9605 T11979 T11983 arg1Of inject,into
R9606 T11981 T11979 arg2Of proteins,inject
R9607 T11981 T11980 arg1Of proteins,effector
R9608 T11986 T11983 arg2Of cells32,into
R9609 T11986 T11984 arg1Of cells32,intestinal
R9610 T11986 T11985 arg1Of cells32,epithelial
R9611 T11986 T11990 arg2Of cells32,of
R9612 T11986 T11991 arg1Of cells32,which
R9613 T11989 T11988 arg1Of subset,a
R9614 T11989 T11990 arg1Of subset,of
R9615 T11989 T11992 arg1Of subset,inhibit
R9616 T11992 T11987 arg1Of inhibit,","
R9617 T11995 T11992 arg2Of responses9,inhibit
R9618 T11995 T11993 arg1Of responses9,NF-κB-dependent
R9619 T11995 T11994 arg1Of responses9,innate
R9620 T11995 T11996 arg1Of responses9,","
R9621 T11997 T11996 arg2Of 33-38,","
R9622 T12001 T12002 arg1Of O157,:
R9623 T12002 T11999 arg1Of :,E.
R9624 T12002 T12000 arg1Of :,coli
R9625 T12003 T12002 arg2Of H7,:
R9626 T12007 T11998 arg1Of NleH1,The
R9627 T12007 T12001 arg1Of NleH1,O157
R9628 T12007 T12003 arg1Of NleH1,H7
R9629 T12007 T12004 arg1Of NleH1,EDL933
R9630 T12007 T12005 arg1Of NleH1,effector
R9631 T12007 T12006 arg1Of NleH1,protein
R9632 T12007 T12008 arg1Of NleH1,binds
R9633 T12007 T12011 arg1Of NleH1,attenuates
R9634 T12007 T12017 arg1Of NleH1,impairing
R9635 T12008 T12009 arg1Of binds,to
R9636 T12008 T12010 arg1Of binds,and
R9637 T12010 T12015 arg1Of and,","
R9638 T12010 T12017 modOf and,impairing
R9639 T12011 T12010 arg2Of attenuates,and
R9640 T12014 T12011 arg2Of translocation,attenuates
R9641 T12014 T12012 arg1Of translocation,RPS3
R9642 T12014 T12013 arg1Of translocation,nuclear
R9643 T12017 T12016 arg1Of impairing,thus
R9644 T12020 T12017 arg2Of signaling9,impairing
R9645 T12020 T12018 arg1Of signaling9,RPS3-dependent
R9646 T12020 T12019 arg1Of signaling9,NF-κB
R9647 T12021 T12023 arg1Of We,hypothesized
R9648 T12023 T12022 arg1Of hypothesized,therefore
R9649 T12025 T12026 arg1Of NleH1,may
R9650 T12025 T12027 arg1Of NleH1,function
R9651 T12025 T12029 arg1Of NleH1,inhibiting
R9652 T12027 T12023 arg2Of function,hypothesized
R9653 T12027 T12024 arg1Of function,that
R9654 T12027 T12026 arg2Of function,may
R9655 T12027 T12028 arg1Of function,by
R9656 T12029 T12028 arg2Of inhibiting,by
R9657 T12032 T12029 arg2Of phosphorylation,inhibiting
R9658 T12032 T12030 arg1Of phosphorylation,RPS3
R9659 T12032 T12031 arg1Of phosphorylation,S209
R9660 T12034 T12033 arg2Of expected,As
R9661 T12038 T12036 arg1Of amounts,transfecting
R9662 T12038 T12037 arg1Of amounts,increasing
R9663 T12038 T12039 arg1Of amounts,of
R9664 T12038 T12042 arg1Of amounts,blocked
R9665 T12041 T12039 arg2Of plasmid,of
R9666 T12041 T12040 arg1Of plasmid,NleH1-HA
R9667 T12042 T12033 arg1Of blocked,As
R9668 T12042 T12035 arg1Of blocked,","
R9669 T12042 T12046 arg1Of blocked,in
R9670 T12045 T12042 arg2Of activation,blocked
R9671 T12045 T12043 arg1Of activation,TNFα-induced
R9672 T12045 T12044 arg1Of activation,NF-κB
R9673 T12051 T12050 arg2Of Fig.,(
R9674 T12051 T12052 arg1Of Fig.,6a-b
R9675 T12053 T12050 arg3Of ),(
R9676 T12054 T12046 arg2Of 9,in
R9677 T12054 T12047 arg1Of 9,a
R9678 T12054 T12048 arg1Of 9,dose-dependent
R9679 T12054 T12049 arg1Of 9,manner
R9680 T12054 T12050 arg1Of 9,(
R9681 T12057 T12058 arg1Of NleH1,reduced
R9682 T12058 T12055 arg1Of reduced,Remarkably
R9683 T12058 T12056 arg1Of reduced,","
R9684 T12058 T12068 arg1Of reduced,to
R9685 T12060 T12064 arg1Of TNF-induced,as
R9686 T12064 T12059 arg1Of as,both
R9687 T12064 T12061 arg1Of as,","
R9688 T12064 T12062 arg1Of as,as
R9689 T12064 T12063 arg1Of as,well
R9690 T12065 T12064 arg2Of basal,as
R9691 T12067 T12058 arg2Of phosphorylation,reduced
R9692 T12067 T12060 arg1Of phosphorylation,TNF-induced
R9693 T12067 T12065 arg1Of phosphorylation,basal
R9694 T12067 T12066 arg1Of phosphorylation,RPS3
R9695 T12070 T12069 arg1Of 20,roughly
R9696 T12071 T12068 arg2Of %,to
R9697 T12071 T12070 arg1Of %,20
R9698 T12071 T12072 arg1Of %,of
R9699 T12074 T12072 arg2Of control,of
R9700 T12074 T12073 arg1Of control,vehicle
R9701 T12074 T12075 arg1Of control,(
R9702 T12077 T12075 arg2Of 6c,(
R9703 T12077 T12076 arg1Of 6c,Fig.
R9704 T12078 T12075 arg3Of ),(
R9705 T12080 T12079 arg1Of NleH1,Expressing
R9706 T12080 T12081 arg1Of NleH1,does
R9707 T12080 T12083 arg1Of NleH1,interfere
R9708 T12083 T12081 arg2Of interfere,does
R9709 T12083 T12082 arg1Of interfere,not
R9710 T12083 T12084 arg1Of interfere,with
R9711 T12083 T12092 arg1Of interfere,","
R9712 T12083 T12093 arg1Of interfere,consistent
R9713 T12088 T12086 arg1Of activation,TNF-induced
R9714 T12088 T12087 arg1Of activation,IKK
R9715 T12088 T12089 arg1Of activation,or
R9716 T12089 T12084 arg2Of or,with
R9717 T12089 T12085 arg1Of or,either
R9718 T12091 T12089 arg2Of degradation,or
R9719 T12091 T12090 arg1Of degradation,IκBα
R9720 T12093 T12094 arg1Of consistent,with
R9721 T12096 T12094 arg2Of lack,with
R9722 T12096 T12095 arg1Of lack,the
R9723 T12096 T12097 arg1Of lack,of
R9724 T12096 T12100 arg1Of lack,on
R9725 T12099 T12097 arg2Of impact,of
R9726 T12099 T12098 arg1Of impact,NleH1
R9727 T12103 T12100 arg2Of translocation9,on
R9728 T12103 T12101 arg1Of translocation9,p65
R9729 T12103 T12102 arg1Of translocation9,nuclear
R9730 T12103 T12104 arg1Of translocation9,(
R9731 T12106 T12104 arg2Of 6c,(
R9732 T12106 T12105 arg1Of 6c,Fig.
R9733 T12107 T12104 arg3Of ),(
R9734 T12109 T12108 arg1Of determine,To
R9735 T12111 T12112 arg1Of NleH1,inhibits
R9736 T12112 T12109 arg2Of inhibits,determine
R9737 T12112 T12110 arg1Of inhibits,if
R9738 T12114 T12112 arg2Of phosphorylation,inhibits
R9739 T12114 T12113 arg1Of phosphorylation,RPS3
R9740 T12116 T12109 arg1Of we,determine
R9741 T12116 T12117 arg1Of we,infected
R9742 T12117 T12108 modOf infected,To
R9743 T12117 T12115 arg1Of infected,","
R9744 T12117 T12120 arg1Of infected,with
R9745 T12117 T12136 arg1Of infected,with
R9746 T12119 T12117 arg2Of cells,infected
R9747 T12119 T12118 arg1Of cells,HeLa
R9748 T12120 T12135 arg1Of with,or
R9749 T12123 T12121 arg1Of O157,E.
R9750 T12123 T12122 arg1Of O157,coli
R9751 T12123 T12124 arg1Of O157,:
R9752 T12124 T12120 arg2Of :,with
R9753 T12126 T12124 arg2Of strains,:
R9754 T12126 T12125 arg1Of strains,H7
R9755 T12126 T12127 arg1Of strains,possessing
R9756 T12126 T12129 arg1Of strains,lacking
R9757 T12127 T12128 arg1Of possessing,or
R9758 T12129 T12128 arg2Of lacking,or
R9759 T12131 T12127 arg2Of nleH1,possessing
R9760 T12131 T12129 arg2Of nleH1,lacking
R9761 T12131 T12130 arg1Of nleH1,either
R9762 T12131 T12132 arg1Of nleH1,(
R9763 T12133 T12132 arg2Of ΔnleH1,(
R9764 T12134 T12132 arg3Of ),(
R9765 T12136 T12135 arg2Of with,or
R9766 T12138 T12136 arg2Of strain,with
R9767 T12138 T12137 arg1Of strain,a
R9768 T12138 T12139 arg1Of strain,lacking
R9769 T12142 T12139 arg2Of T3SS,lacking
R9770 T12142 T12140 arg1Of T3SS,a
R9771 T12142 T12141 arg1Of T3SS,functional
R9772 T12142 T12143 arg1Of T3SS,unable
R9773 T12145 T12143 arg2Of inject,unable
R9774 T12145 T12144 arg1Of inject,to
R9775 T12146 T12145 arg2Of NleH1,inject
R9776 T12146 T12147 arg1Of NleH1,into
R9777 T12149 T12147 arg2Of cells,into
R9778 T12149 T12148 arg1Of cells,mammalian
R9779 T12149 T12150 arg1Of cells,(
R9780 T12151 T12150 arg2Of ΔescN,(
R9781 T12152 T12150 arg3Of ),(
R9782 T12155 T12153 arg2Of cells,In
R9783 T12155 T12154 arg1Of cells,uninfected
R9784 T12157 T12158 arg1Of TNF-treatment,stimulated
R9785 T12157 T12167 arg1Of TNF-treatment,peaking
R9786 T12158 T12153 arg1Of stimulated,In
R9787 T12158 T12156 arg1Of stimulated,","
R9788 T12158 T12166 arg1Of stimulated,","
R9789 T12158 T12167 modOf stimulated,peaking
R9790 T12161 T12158 arg2Of increase,stimulated
R9791 T12161 T12159 arg1Of increase,a
R9792 T12161 T12160 arg1Of increase,∼7-fold
R9793 T12161 T12162 arg1Of increase,in
R9794 T12165 T12162 arg2Of phosphorylation,in
R9795 T12165 T12163 arg1Of phosphorylation,RPS3
R9796 T12165 T12164 arg1Of phosphorylation,S209
R9797 T12167 T12168 arg1Of peaking,at
R9798 T12167 T12171 arg1Of peaking,(
R9799 T12170 T12168 arg2Of minutes,at
R9800 T12170 T12169 arg1Of minutes,30
R9801 T12172 T12171 arg2Of Fig.,(
R9802 T12172 T12173 arg1Of Fig.,6d
R9803 T12174 T12171 arg3Of ),(
R9804 T12176 T12175 arg2Of contrast,By
R9805 T12180 T12178 arg1Of phosphorylation,RPS3
R9806 T12180 T12179 arg1Of phosphorylation,S209
R9807 T12180 T12181 arg1Of phosphorylation,was
R9808 T12180 T12183 arg1Of phosphorylation,impaired
R9809 T12181 T12175 arg1Of was,By
R9810 T12181 T12177 arg1Of was,","
R9811 T12181 T12184 arg1Of was,in
R9812 T12181 T12194 arg1Of was,(
R9813 T12183 T12181 arg2Of impaired,was
R9814 T12183 T12182 arg1Of impaired,substantially
R9815 T12185 T12184 arg2Of cells,in
R9816 T12185 T12186 arg2Of cells,infected
R9817 T12185 T12192 arg1Of cells,:
R9818 T12186 T12187 arg1Of infected,with
R9819 T12191 T12187 arg2Of O157,with
R9820 T12191 T12188 arg1Of O157,wild-type
R9821 T12191 T12189 arg1Of O157,E.
R9822 T12191 T12190 arg1Of O157,coli
R9823 T12193 T12192 arg2Of H7,:
R9824 T12195 T12194 arg2Of Fig.,(
R9825 T12195 T12196 arg1Of Fig.,6d
R9826 T12197 T12194 arg3Of ),(
R9827 T12203 T12200 arg1Of phosphorylation,TNF-induced
R9828 T12203 T12201 arg1Of phosphorylation,RPS3
R9829 T12203 T12202 arg1Of phosphorylation,S209
R9830 T12203 T12204 arg1Of phosphorylation,was
R9831 T12203 T12205 arg1Of phosphorylation,unimpaired
R9832 T12204 T12198 arg1Of was,However
R9833 T12204 T12199 arg1Of was,","
R9834 T12204 T12206 arg1Of was,in
R9835 T12205 T12204 arg2Of unimpaired,was
R9836 T12207 T12206 arg2Of cells,in
R9837 T12207 T12208 arg2Of cells,infected
R9838 T12208 T12209 arg1Of infected,with
R9839 T12208 T12214 arg1Of infected,(
R9840 T12211 T12212 arg1Of ΔnleH1,or
R9841 T12212 T12209 arg2Of or,with
R9842 T12212 T12210 arg1Of or,either
R9843 T12213 T12212 arg2Of ΔescN,or
R9844 T12215 T12214 arg2Of Fig.,(
R9845 T12215 T12216 arg1Of Fig.,6d
R9846 T12217 T12214 arg3Of ),(
R9847 T12218 T12219 arg1Of We,showed
R9848 T12219 T12220 arg1Of showed,previously
R9849 T12222 T12224 arg1Of wild-type,but
R9850 T12224 T12223 arg1Of but,","
R9851 T12224 T12225 arg1Of but,not
R9852 T12224 T12227 arg1Of but,or
R9853 T12226 T12224 arg2Of ΔnleH1,but
R9854 T12227 T12232 arg1Of or,:
R9855 T12231 T12227 arg2Of O157,or
R9856 T12231 T12228 arg1Of O157,ΔescN
R9857 T12231 T12229 arg1Of O157,E.
R9858 T12231 T12230 arg1Of O157,coli
R9859 T12232 T12235 arg1Of :,attenuated
R9860 T12233 T12232 arg2Of H7,:
R9861 T12235 T12219 arg2Of attenuated,showed
R9862 T12235 T12221 arg1Of attenuated,that
R9863 T12235 T12234 arg1Of attenuated,significantly
R9864 T12239 T12235 arg2Of translocation9,attenuated
R9865 T12239 T12236 arg1Of translocation9,TNF-induced
R9866 T12239 T12237 arg1Of translocation9,RPS3
R9867 T12239 T12238 arg1Of translocation9,nuclear
R9868 T12241 T12240 arg1Of parallel,The
R9869 T12241 T12242 arg1Of parallel,between
R9870 T12241 T12249 arg1Of parallel,during
R9871 T12241 T12253 arg1Of parallel,provides
R9872 T12244 T12243 arg1Of phosphorylation,RPS3
R9873 T12244 T12245 arg1Of phosphorylation,and
R9874 T12245 T12242 arg2Of and,between
R9875 T12248 T12245 arg2Of translocation,and
R9876 T12248 T12246 arg1Of translocation,its
R9877 T12248 T12247 arg1Of translocation,nuclear
R9878 T12252 T12249 arg2Of infection,during
R9879 T12252 T12250 arg1Of infection,E.
R9880 T12252 T12251 arg1Of infection,coli
R9881 T12254 T12253 arg2Of evidence,provides
R9882 T12254 T12255 arg1Of evidence,in
R9883 T12257 T12255 arg2Of context,in
R9884 T12257 T12256 arg1Of context,the
R9885 T12257 T12258 arg1Of context,of
R9886 T12262 T12258 arg2Of process,of
R9887 T12262 T12259 arg1Of process,an
R9888 T12262 T12260 arg1Of process,NF-κB-dependent
R9889 T12262 T12261 arg1Of process,disease
R9890 T12266 T12263 arg1Of phosphorylation,that
R9891 T12266 T12264 arg1Of phosphorylation,RPS3
R9892 T12266 T12265 arg1Of phosphorylation,S209
R9893 T12266 T12267 arg1Of phosphorylation,is
R9894 T12266 T12268 arg1Of phosphorylation,important
R9895 T12267 T12253 arg3Of is,provides
R9896 T12268 T12267 arg2Of important,is
R9897 T12268 T12269 arg1Of important,for
R9898 T12271 T12269 arg2Of translocation,for
R9899 T12271 T12270 arg1Of translocation,nuclear
R9900 T12273 T12272 arg1Of discovery,Our
R9901 T12273 T12280 arg1Of discovery,suggested
R9902 T12275 T12276 arg1Of NleH1,inhibits
R9903 T12276 T12273 arg2Of inhibits,discovery
R9904 T12276 T12274 arg1Of inhibits,that
R9905 T12279 T12276 arg2Of phosphorylation,inhibits
R9906 T12279 T12277 arg1Of phosphorylation,RPS3
R9907 T12279 T12278 arg1Of phosphorylation,S209
R9908 T12282 T12283 arg1Of it,should
R9909 T12282 T12285 arg1Of it,blocks
R9910 T12285 T12280 arg2Of blocks,suggested
R9911 T12285 T12281 arg1Of blocks,that
R9912 T12285 T12283 arg2Of blocks,should
R9913 T12285 T12284 arg1Of blocks,also
R9914 T12290 T12285 arg2Of transcription,blocks
R9915 T12290 T12286 arg1Of transcription,RPS3-dependent
R9916 T12290 T12287 arg1Of transcription,NF-κB
R9917 T12290 T12288 arg1Of transcription,target
R9918 T12290 T12289 arg1Of transcription,gene
R9919 T12290 T12291 arg1Of transcription,(
R9920 T12293 T12294 arg1Of IL8,","
R9921 T12294 T12297 arg1Of ",",and
R9922 T12295 T12294 arg2Of NFKBIA,","
R9923 T12297 T12291 arg2Of and,(
R9924 T12297 T12292 arg1Of and,e.g.
R9925 T12297 T12296 arg1Of and,","
R9926 T12298 T12297 arg2Of TNFAIP3,and
R9927 T12299 T12291 arg3Of ),(
R9928 T12303 T12302 arg1Of genes,these
R9929 T12303 T12304 arg1Of genes,were
R9930 T12303 T12307 arg2Of genes,upregulated
R9931 T12303 T12321 arg2Of genes,induced
R9932 T12306 T12305 arg1Of modestly,only
R9933 T12307 T12308 arg1Of upregulated,in
R9934 T12307 T12316 arg1Of upregulated,:
R9935 T12307 T12319 arg1Of upregulated,but
R9936 T12309 T12308 arg2Of cells,in
R9937 T12309 T12310 arg2Of cells,infected
R9938 T12310 T12311 arg1Of infected,with
R9939 T12315 T12311 arg2Of O157,with
R9940 T12315 T12312 arg1Of O157,wild-type
R9941 T12315 T12313 arg1Of O157,E.
R9942 T12315 T12314 arg1Of O157,coli
R9943 T12317 T12307 arg3Of H7,upregulated
R9944 T12319 T12300 arg1Of but,Indeed
R9945 T12319 T12301 arg1Of but,","
R9946 T12319 T12304 arg2Of but,were
R9947 T12319 T12306 arg1Of but,modestly
R9948 T12319 T12318 arg1Of but,","
R9949 T12321 T12319 arg2Of induced,but
R9950 T12321 T12320 arg1Of induced,significantly
R9951 T12321 T12322 arg1Of induced,in
R9952 T12323 T12322 arg2Of cells,in
R9953 T12323 T12324 arg2Of cells,infected
R9954 T12324 T12325 arg1Of infected,with
R9955 T12327 T12328 arg1Of ΔnleH1,or
R9956 T12329 T12328 arg2Of ΔescN,or
R9957 T12330 T12325 arg2Of strains,with
R9958 T12330 T12326 arg1Of strains,either
R9959 T12330 T12327 arg1Of strains,ΔnleH1
R9960 T12330 T12329 arg1Of strains,ΔescN
R9961 T12330 T12331 arg1Of strains,(
R9962 T12333 T12331 arg2Of 6e,(
R9963 T12333 T12332 arg1Of 6e,Fig.
R9964 T12334 T12331 arg3Of ),(
R9965 T12336 T12335 arg2Of contrast,In
R9966 T12338 T12340 arg1Of deleting,had
R9967 T12339 T12338 arg2Of nleH1,deleting
R9968 T12340 T12335 arg1Of had,In
R9969 T12340 T12337 arg1Of had,","
R9970 T12340 T12343 arg1Of had,on
R9971 T12342 T12340 arg2Of impact,had
R9972 T12342 T12341 arg1Of impact,no
R9973 T12345 T12343 arg2Of expression,on
R9974 T12345 T12344 arg1Of expression,the
R9975 T12345 T12346 arg1Of expression,of
R9976 T12348 T12346 arg2Of genes,of
R9977 T12348 T12347 arg1Of genes,RPS3-independent
R9978 T12348 T12349 arg1Of genes,","
R9979 T12348 T12350 arg1Of genes,including
R9980 T12351 T12352 arg1Of CD25,and
R9981 T12352 T12350 arg2Of and,including
R9982 T12352 T12354 arg1Of and,(
R9983 T12353 T12352 arg2Of TNFSF13B,and
R9984 T12356 T12354 arg2Of Fig.,(
R9985 T12356 T12355 arg1Of Fig.,Supplementary
R9986 T12356 T12357 arg1Of Fig.,12
R9987 T12358 T12354 arg3Of ),(
R9988 T12361 T12360 arg1Of results,these
R9989 T12361 T12362 arg1Of results,demonstrate
R9990 T12362 T12359 arg1Of demonstrate,Together
R9991 T12364 T12366 arg1Of NleH1,inhibits
R9992 T12366 T12362 arg2Of inhibits,demonstrate
R9993 T12366 T12363 arg1Of inhibits,that
R9994 T12366 T12365 arg1Of inhibits,specifically
R9995 T12366 T12371 arg1Of inhibits,by
R9996 T12370 T12366 arg2Of response,inhibits
R9997 T12370 T12367 arg1Of response,the
R9998 T12370 T12368 arg1Of response,protective
R9999 T12370 T12369 arg1Of response,immune
R10000 T12373 T12372 arg1Of blocking,directly
R10001 T12373 T12377 arg1Of blocking,and
R10002 T12376 T12373 arg2Of phosphorylation,blocking
R10003 T12376 T12374 arg1Of phosphorylation,RPS3
R10004 T12376 T12375 arg1Of phosphorylation,S209
R10005 T12377 T12371 arg2Of and,by
R10006 T12379 T12377 arg2Of impairing,and
R10007 T12379 T12378 arg1Of impairing,thereby
R10008 T12384 T12379 arg2Of genes,impairing
R10009 T12384 T12380 arg1Of genes,critical
R10010 T12384 T12381 arg1Of genes,RPS3-dependent
R10011 T12384 T12382 arg1Of genes,NF-κB
R10012 T12384 T12383 arg1Of genes,target

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T12385 1804-1807 Anaphor denotes its
T12386 1779-1783 Antecedent denotes RPS3
R10013 T12385 T12386 boundBy its,RPS3

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T12437 0-5 CD denotes NleH1
T12438 6-14 NNS denotes inhibits
T12439 15-19 JJ denotes RPS3
T12440 20-35 NN denotes phosphorylation
T12441 36-38 IN denotes in
T12442 39-44 NN denotes vitro
T12443 45-49 NNP denotes EHEC
T12444 50-59 NNS denotes pathogens
T12445 60-63 VBP denotes are
T12446 64-73 JJ denotes important
T12447 74-83 JJ denotes causative
T12448 84-90 NNS denotes agents
T12449 91-93 IN denotes of
T12450 94-98 DT denotes both
T12451 99-108 JJ denotes foodborne
T12452 109-116 NN denotes disease
T12453 117-120 CC denotes and
T12454 121-130 JJ denotes pediatric
T12455 131-136 JJ denotes renal
T12456 137-146 NN denotes failure31
T12457 146-147 . denotes .
T12458 148-152 NNP denotes EHEC
T12459 153-160 VB denotes utilize
T12460 161-165 CD denotes T3SS
T12461 166-168 TO denotes to
T12462 169-175 VB denotes inject
T12463 176-184 NN denotes effector
T12464 185-193 NNS denotes proteins
T12465 194-202 RB denotes directly
T12466 203-207 IN denotes into
T12467 208-218 JJ denotes intestinal
T12468 219-229 JJ denotes epithelial
T12469 230-237 NN denotes cells32
T12470 237-238 , denotes ,
T12471 239-240 DT denotes a
T12472 241-247 NN denotes subset
T12473 248-250 IN denotes of
T12474 251-256 WDT denotes which
T12475 257-264 VBP denotes inhibit
T12476 265-280 JJ denotes NF-κB-dependent
T12477 281-287 NN denotes innate
T12478 288-298 CD denotes responses9
T12479 298-299 , denotes ,
T12480 300-305 CD denotes 33-38
T12481 305-306 . denotes .
T12482 307-310 DT denotes The
T12483 311-313 NNP denotes E.
T12484 314-318 NNS denotes coli
T12485 319-323 NNP denotes O157
T12486 323-324 : denotes :
T12487 324-326 NNP denotes H7
T12488 327-333 NNP denotes EDL933
T12489 334-342 NN denotes effector
T12490 343-350 NN denotes protein
T12491 351-356 NNP denotes NleH1
T12492 357-362 VBZ denotes binds
T12493 363-365 TO denotes to
T12494 366-369 CC denotes and
T12495 370-380 VBZ denotes attenuates
T12496 381-385 NNP denotes RPS3
T12497 386-393 JJ denotes nuclear
T12498 394-407 NN denotes translocation
T12499 407-408 , denotes ,
T12500 409-413 RB denotes thus
T12501 414-423 VBG denotes impairing
T12502 424-438 JJ denotes RPS3-dependent
T12503 439-444 NNP denotes NF-κB
T12504 445-455 CD denotes signaling9
T12505 455-456 . denotes .
T12506 457-459 PRP denotes We
T12507 460-469 RB denotes therefore
T12508 470-482 VBD denotes hypothesized
T12509 483-487 IN denotes that
T12510 488-493 NNP denotes NleH1
T12511 494-497 MD denotes may
T12512 498-506 VB denotes function
T12513 507-509 IN denotes by
T12514 510-520 VBG denotes inhibiting
T12515 521-525 NNP denotes RPS3
T12516 526-530 NNP denotes S209
T12517 531-546 NN denotes phosphorylation
T12518 546-547 . denotes .
T12519 548-550 IN denotes As
T12520 551-559 VBN denotes expected
T12521 559-560 , denotes ,
T12522 561-573 VBG denotes transfecting
T12523 574-584 VBG denotes increasing
T12524 585-592 NNS denotes amounts
T12525 593-595 IN denotes of
T12526 596-604 JJ denotes NleH1-HA
T12527 605-612 JJ denotes plasmid
T12528 613-620 VBN denotes blocked
T12529 621-633 JJ denotes TNFα-induced
T12530 634-639 NN denotes NF-κB
T12531 640-650 NN denotes activation
T12532 651-653 IN denotes in
T12533 654-655 DT denotes a
T12534 656-670 JJ denotes dose-dependent
T12535 671-677 NN denotes manner
T12536 678-679 -LRB- denotes (
T12537 679-683 NNP denotes Fig.
T12538 684-688 JJ denotes 6a-b
T12539 688-689 -RRB- denotes )
T12540 689-690 CD denotes 9
T12541 690-691 . denotes .
T12542 692-702 RB denotes Remarkably
T12543 702-703 , denotes ,
T12544 704-709 NNP denotes NleH1
T12545 710-717 VBD denotes reduced
T12546 718-722 DT denotes both
T12547 723-734 JJ denotes TNF-induced
T12548 734-735 , denotes ,
T12549 736-738 RB denotes as
T12550 739-743 RB denotes well
T12551 744-746 IN denotes as
T12552 747-752 JJ denotes basal
T12553 753-757 JJ denotes RPS3
T12554 758-773 NN denotes phosphorylation
T12555 774-776 TO denotes to
T12556 777-784 RB denotes roughly
T12557 785-787 CD denotes 20
T12558 787-788 NN denotes %
T12559 789-791 IN denotes of
T12560 792-799 NN denotes vehicle
T12561 800-807 NN denotes control
T12562 808-809 -LRB- denotes (
T12563 809-813 NNP denotes Fig.
T12564 814-816 CD denotes 6c
T12565 816-817 -RRB- denotes )
T12566 817-818 . denotes .
T12567 819-829 VBG denotes Expressing
T12568 830-835 NN denotes NleH1
T12569 836-840 VBZ denotes does
T12570 841-844 RB denotes not
T12571 845-854 VB denotes interfere
T12572 855-859 IN denotes with
T12573 860-866 DT denotes either
T12574 867-878 JJ denotes TNF-induced
T12575 879-882 NNP denotes IKK
T12576 883-893 NN denotes activation
T12577 894-896 CC denotes or
T12578 897-901 NN denotes IκBα
T12579 902-913 NN denotes degradation
T12580 913-914 , denotes ,
T12581 915-925 JJ denotes consistent
T12582 926-930 IN denotes with
T12583 931-934 DT denotes the
T12584 935-939 NN denotes lack
T12585 940-942 IN denotes of
T12586 943-948 JJ denotes NleH1
T12587 949-955 NN denotes impact
T12588 956-958 IN denotes on
T12589 959-962 CD denotes p65
T12590 963-970 JJ denotes nuclear
T12591 971-985 NNS denotes translocation9
T12592 986-987 -LRB- denotes (
T12593 987-991 NNP denotes Fig.
T12594 992-994 CD denotes 6c
T12595 994-995 -RRB- denotes )
T12596 995-996 . denotes .
T12597 997-999 TO denotes To
T12598 1000-1009 VB denotes determine
T12599 1010-1012 IN denotes if
T12600 1013-1018 JJ denotes NleH1
T12601 1019-1027 NNS denotes inhibits
T12602 1028-1032 JJ denotes RPS3
T12603 1033-1048 NN denotes phosphorylation
T12604 1048-1049 , denotes ,
T12605 1050-1052 PRP denotes we
T12606 1053-1061 VBD denotes infected
T12607 1062-1066 NNP denotes HeLa
T12608 1067-1072 NNS denotes cells
T12609 1073-1077 IN denotes with
T12610 1078-1080 NNP denotes E.
T12611 1081-1085 NNS denotes coli
T12612 1086-1090 NNP denotes O157
T12613 1090-1091 : denotes :
T12614 1091-1093 NNP denotes H7
T12615 1094-1101 NNS denotes strains
T12616 1102-1112 VBG denotes possessing
T12617 1113-1115 CC denotes or
T12618 1116-1123 VBG denotes lacking
T12619 1124-1130 CC denotes either
T12620 1131-1136 NNP denotes nleH1
T12621 1137-1138 -LRB- denotes (
T12622 1138-1144 NNP denotes ΔnleH1
T12623 1144-1145 -RRB- denotes )
T12624 1146-1148 CC denotes or
T12625 1149-1153 IN denotes with
T12626 1154-1155 DT denotes a
T12627 1156-1162 NN denotes strain
T12628 1163-1170 VBG denotes lacking
T12629 1171-1172 DT denotes a
T12630 1173-1183 JJ denotes functional
T12631 1184-1188 CD denotes T3SS
T12632 1189-1195 JJ denotes unable
T12633 1196-1198 TO denotes to
T12634 1199-1205 VB denotes inject
T12635 1206-1211 NNP denotes NleH1
T12636 1212-1216 IN denotes into
T12637 1217-1226 JJ denotes mammalian
T12638 1227-1232 NNS denotes cells
T12639 1233-1234 -LRB- denotes (
T12640 1234-1239 NNP denotes ΔescN
T12641 1239-1240 -RRB- denotes )
T12642 1240-1241 . denotes .
T12643 1242-1244 IN denotes In
T12644 1245-1255 JJ denotes uninfected
T12645 1256-1261 NNS denotes cells
T12646 1261-1262 , denotes ,
T12647 1263-1276 JJ denotes TNF-treatment
T12648 1277-1287 VBD denotes stimulated
T12649 1288-1289 DT denotes a
T12650 1290-1291 NN denotes ∼
T12651 1291-1297 JJ denotes 7-fold
T12652 1298-1306 NN denotes increase
T12653 1307-1309 IN denotes in
T12654 1310-1314 NNP denotes RPS3
T12655 1315-1319 NNP denotes S209
T12656 1320-1335 NN denotes phosphorylation
T12657 1335-1336 , denotes ,
T12658 1337-1344 VBG denotes peaking
T12659 1345-1347 IN denotes at
T12660 1348-1350 CD denotes 30
T12661 1351-1358 NNS denotes minutes
T12662 1359-1360 -LRB- denotes (
T12663 1360-1364 NNP denotes Fig.
T12664 1365-1367 CD denotes 6d
T12665 1367-1368 -RRB- denotes )
T12666 1368-1369 . denotes .
T12667 1370-1372 IN denotes By
T12668 1373-1381 NN denotes contrast
T12669 1381-1382 , denotes ,
T12670 1383-1387 NNP denotes RPS3
T12671 1388-1392 NNP denotes S209
T12672 1393-1408 NN denotes phosphorylation
T12673 1409-1412 VBD denotes was
T12674 1413-1426 RB denotes substantially
T12675 1427-1435 VBN denotes impaired
T12676 1436-1438 IN denotes in
T12677 1439-1444 NNS denotes cells
T12678 1445-1453 VBN denotes infected
T12679 1454-1458 IN denotes with
T12680 1459-1468 JJ denotes wild-type
T12681 1469-1471 NNP denotes E.
T12682 1472-1476 NNS denotes coli
T12683 1477-1481 NNP denotes O157
T12684 1481-1482 : denotes :
T12685 1482-1484 NNP denotes H7
T12686 1485-1486 -LRB- denotes (
T12687 1486-1490 NNP denotes Fig.
T12688 1491-1493 CD denotes 6d
T12689 1493-1494 -RRB- denotes )
T12690 1494-1495 . denotes .
T12691 1496-1503 RB denotes However
T12692 1503-1504 , denotes ,
T12693 1505-1516 JJ denotes TNF-induced
T12694 1517-1521 NNP denotes RPS3
T12695 1522-1526 NNP denotes S209
T12696 1527-1542 NN denotes phosphorylation
T12697 1543-1546 VBD denotes was
T12698 1547-1557 VBN denotes unimpaired
T12699 1558-1560 IN denotes in
T12700 1561-1566 NNS denotes cells
T12701 1567-1575 VBN denotes infected
T12702 1576-1580 IN denotes with
T12703 1581-1587 DT denotes either
T12704 1588-1594 NNP denotes ΔnleH1
T12705 1595-1597 CC denotes or
T12706 1598-1603 NNP denotes ΔescN
T12707 1604-1605 -LRB- denotes (
T12708 1605-1609 NNP denotes Fig.
T12709 1610-1612 CD denotes 6d
T12710 1612-1613 -RRB- denotes )
T12711 1613-1614 . denotes .
T12712 1615-1617 PRP denotes We
T12713 1618-1624 VBD denotes showed
T12714 1625-1635 RB denotes previously
T12715 1636-1640 IN denotes that
T12716 1641-1650 JJ denotes wild-type
T12717 1650-1651 , denotes ,
T12718 1652-1655 CC denotes but
T12719 1656-1659 RB denotes not
T12720 1660-1666 JJ denotes ΔnleH1
T12721 1667-1669 CC denotes or
T12722 1670-1675 NNP denotes ΔescN
T12723 1676-1678 NNP denotes E.
T12724 1679-1683 NNS denotes coli
T12725 1684-1688 NNP denotes O157
T12726 1688-1689 : denotes :
T12727 1689-1691 NNP denotes H7
T12728 1692-1705 RB denotes significantly
T12729 1706-1716 VBD denotes attenuated
T12730 1717-1728 JJ denotes TNF-induced
T12731 1729-1733 JJ denotes RPS3
T12732 1734-1741 JJ denotes nuclear
T12733 1742-1756 NNS denotes translocation9
T12734 1756-1757 . denotes .
T12735 1758-1761 DT denotes The
T12736 1762-1770 NN denotes parallel
T12737 1771-1778 IN denotes between
T12738 1779-1783 CD denotes RPS3
T12739 1784-1799 NN denotes phosphorylation
T12740 1800-1803 CC denotes and
T12741 1804-1807 PRP$ denotes its
T12742 1808-1815 JJ denotes nuclear
T12743 1816-1829 NN denotes translocation
T12744 1830-1836 IN denotes during
T12745 1837-1839 NNP denotes E.
T12746 1840-1844 NNS denotes coli
T12747 1845-1854 NN denotes infection
T12748 1855-1863 VBZ denotes provides
T12749 1864-1872 NN denotes evidence
T12750 1873-1875 IN denotes in
T12751 1876-1879 DT denotes the
T12752 1880-1887 NN denotes context
T12753 1888-1890 IN denotes of
T12754 1891-1893 DT denotes an
T12755 1894-1909 JJ denotes NF-κB-dependent
T12756 1910-1917 NN denotes disease
T12757 1918-1925 NN denotes process
T12758 1926-1930 WDT denotes that
T12759 1931-1935 NNP denotes RPS3
T12760 1936-1940 NNP denotes S209
T12761 1941-1956 NN denotes phosphorylation
T12762 1957-1959 VBZ denotes is
T12763 1960-1969 JJ denotes important
T12764 1970-1973 IN denotes for
T12765 1974-1981 JJ denotes nuclear
T12766 1982-1995 NN denotes translocation
T12767 1995-1996 . denotes .
T12768 1997-2000 PRP$ denotes Our
T12769 2001-2010 NN denotes discovery
T12770 2011-2015 IN denotes that
T12771 2016-2021 NNP denotes NleH1
T12772 2022-2030 VBZ denotes inhibits
T12773 2031-2035 NNP denotes RPS3
T12774 2036-2040 NNP denotes S209
T12775 2041-2056 NN denotes phosphorylation
T12776 2057-2066 VBD denotes suggested
T12777 2067-2071 IN denotes that
T12778 2072-2074 PRP denotes it
T12779 2075-2081 MD denotes should
T12780 2082-2086 RB denotes also
T12781 2087-2093 NNS denotes blocks
T12782 2094-2108 JJ denotes RPS3-dependent
T12783 2109-2114 NN denotes NF-κB
T12784 2115-2121 NN denotes target
T12785 2122-2126 NN denotes gene
T12786 2127-2140 NN denotes transcription
T12787 2141-2142 -LRB- denotes (
T12788 2142-2146 FW denotes e.g.
T12789 2147-2150 FW denotes IL8
T12790 2150-2151 , denotes ,
T12791 2152-2158 NNP denotes NFKBIA
T12792 2158-2159 , denotes ,
T12793 2160-2163 CC denotes and
T12794 2164-2171 CD denotes TNFAIP3
T12795 2171-2172 -RRB- denotes )
T12796 2172-2173 . denotes .
T12797 2174-2180 RB denotes Indeed
T12798 2180-2181 , denotes ,
T12799 2182-2187 DT denotes these
T12800 2188-2193 NNS denotes genes
T12801 2194-2198 VBD denotes were
T12802 2199-2203 RB denotes only
T12803 2204-2212 RB denotes modestly
T12804 2213-2224 VBN denotes upregulated
T12805 2225-2227 IN denotes in
T12806 2228-2233 NNS denotes cells
T12807 2234-2242 VBN denotes infected
T12808 2243-2247 IN denotes with
T12809 2248-2257 JJ denotes wild-type
T12810 2258-2260 NNP denotes E.
T12811 2261-2265 NNS denotes coli
T12812 2266-2270 NNP denotes O157
T12813 2270-2271 : denotes :
T12814 2271-2273 NNP denotes H7
T12815 2273-2274 , denotes ,
T12816 2275-2278 CC denotes but
T12817 2279-2292 RB denotes significantly
T12818 2293-2300 VBD denotes induced
T12819 2301-2303 IN denotes in
T12820 2304-2309 NNS denotes cells
T12821 2310-2318 VBN denotes infected
T12822 2319-2323 IN denotes with
T12823 2324-2330 DT denotes either
T12824 2331-2337 NNP denotes ΔnleH1
T12825 2338-2340 CC denotes or
T12826 2341-2346 NNP denotes ΔescN
T12827 2347-2354 NNS denotes strains
T12828 2355-2356 -LRB- denotes (
T12829 2356-2360 NNP denotes Fig.
T12830 2361-2363 CD denotes 6e
T12831 2363-2364 -RRB- denotes )
T12832 2364-2365 . denotes .
T12833 2366-2368 IN denotes In
T12834 2369-2377 NN denotes contrast
T12835 2377-2378 , denotes ,
T12836 2379-2387 VBG denotes deleting
T12837 2388-2393 NNP denotes nleH1
T12838 2394-2397 VBD denotes had
T12839 2398-2400 DT denotes no
T12840 2401-2407 NN denotes impact
T12841 2408-2410 IN denotes on
T12842 2411-2414 DT denotes the
T12843 2415-2425 NN denotes expression
T12844 2426-2428 IN denotes of
T12845 2429-2445 JJ denotes RPS3-independent
T12846 2446-2451 NNS denotes genes
T12847 2451-2452 , denotes ,
T12848 2453-2462 VBG denotes including
T12849 2463-2467 NNP denotes CD25
T12850 2468-2471 CC denotes and
T12851 2472-2480 NNP denotes TNFSF13B
T12852 2481-2482 -LRB- denotes (
T12853 2482-2495 NNP denotes Supplementary
T12854 2496-2500 NNP denotes Fig.
T12855 2501-2503 CD denotes 12
T12856 2503-2504 -RRB- denotes )
T12857 2504-2505 . denotes .
T12858 2506-2514 RB denotes Together
T12859 2515-2520 DT denotes these
T12860 2521-2528 NNS denotes results
T12861 2529-2540 VBP denotes demonstrate
T12862 2541-2545 IN denotes that
T12863 2546-2551 JJ denotes NleH1
T12864 2552-2564 RB denotes specifically
T12865 2565-2573 VBZ denotes inhibits
T12866 2574-2577 DT denotes the
T12867 2578-2588 JJ denotes protective
T12868 2589-2595 JJ denotes immune
T12869 2596-2604 NN denotes response
T12870 2605-2607 IN denotes by
T12871 2608-2616 RB denotes directly
T12872 2617-2625 VBG denotes blocking
T12873 2626-2630 NNP denotes RPS3
T12874 2631-2635 NNP denotes S209
T12875 2636-2651 NN denotes phosphorylation
T12876 2652-2655 CC denotes and
T12877 2656-2663 RB denotes thereby
T12878 2664-2673 VBG denotes impairing
T12879 2674-2682 JJ denotes critical
T12880 2683-2697 JJ denotes RPS3-dependent
T12881 2698-2703 NN denotes NF-κB
T12882 2704-2710 NN denotes target
T12883 2711-2716 NNS denotes genes
T12884 2716-2717 . denotes .
R10014 T12437 T12438 nummod NleH1,inhibits
R10015 T12438 T12445 nsubj inhibits,are
R10016 T12439 T12440 compound RPS3,phosphorylation
R10017 T12440 T12438 dobj phosphorylation,inhibits
R10018 T12441 T12438 prep in,inhibits
R10019 T12442 T12444 amod vitro,pathogens
R10020 T12443 T12444 compound EHEC,pathogens
R10021 T12444 T12441 pobj pathogens,in
R10022 T12445 T12445 ROOT are,are
R10023 T12446 T12448 amod important,agents
R10024 T12447 T12448 amod causative,agents
R10025 T12448 T12445 attr agents,are
R10026 T12449 T12448 prep of,agents
R10027 T12450 T12452 det both,disease
R10028 T12451 T12452 amod foodborne,disease
R10029 T12452 T12449 pobj disease,of
R10030 T12453 T12452 cc and,disease
R10031 T12454 T12456 amod pediatric,failure31
R10032 T12455 T12456 amod renal,failure31
R10033 T12456 T12452 conj failure31,disease
R10034 T12457 T12445 punct .,are
R10035 T12458 T12459 nsubj EHEC,utilize
R10036 T12459 T12459 ROOT utilize,utilize
R10037 T12460 T12459 dobj T3SS,utilize
R10038 T12461 T12462 aux to,inject
R10039 T12462 T12459 xcomp inject,utilize
R10040 T12463 T12464 compound effector,proteins
R10041 T12464 T12462 dobj proteins,inject
R10042 T12465 T12466 advmod directly,into
R10043 T12466 T12462 prep into,inject
R10044 T12467 T12469 amod intestinal,cells32
R10045 T12468 T12469 amod epithelial,cells32
R10046 T12469 T12466 pobj cells32,into
R10047 T12470 T12475 punct ",",inhibit
R10048 T12471 T12472 det a,subset
R10049 T12472 T12475 nsubj subset,inhibit
R10050 T12473 T12472 prep of,subset
R10051 T12474 T12473 pobj which,of
R10052 T12475 T12459 conj inhibit,utilize
R10053 T12476 T12477 advmod NF-κB-dependent,innate
R10054 T12477 T12480 amod innate,33-38
R10055 T12478 T12477 appos responses9,innate
R10056 T12479 T12477 punct ",",innate
R10057 T12480 T12475 dobj 33-38,inhibit
R10058 T12481 T12475 punct .,inhibit
R10059 T12482 T12485 det The,O157
R10060 T12483 T12485 compound E.,O157
R10061 T12484 T12485 compound coli,O157
R10062 T12485 T12485 ROOT O157,O157
R10063 T12486 T12485 punct :,O157
R10064 T12487 T12490 compound H7,protein
R10065 T12488 T12490 compound EDL933,protein
R10066 T12489 T12490 compound effector,protein
R10067 T12490 T12492 nsubj protein,binds
R10068 T12491 T12492 nsubj NleH1,binds
R10069 T12492 T12492 ROOT binds,binds
R10070 T12493 T12492 prep to,binds
R10071 T12494 T12492 cc and,binds
R10072 T12495 T12492 conj attenuates,binds
R10073 T12496 T12498 nmod RPS3,translocation
R10074 T12497 T12498 amod nuclear,translocation
R10075 T12498 T12495 dobj translocation,attenuates
R10076 T12499 T12492 punct ",",binds
R10077 T12500 T12501 advmod thus,impairing
R10078 T12501 T12492 advcl impairing,binds
R10079 T12502 T12503 compound RPS3-dependent,NF-κB
R10080 T12503 T12504 compound NF-κB,signaling9
R10081 T12504 T12501 dobj signaling9,impairing
R10082 T12505 T12492 punct .,binds
R10083 T12506 T12508 nsubj We,hypothesized
R10084 T12507 T12508 advmod therefore,hypothesized
R10085 T12508 T12508 ROOT hypothesized,hypothesized
R10086 T12509 T12512 mark that,function
R10087 T12510 T12512 nsubj NleH1,function
R10088 T12511 T12512 aux may,function
R10089 T12512 T12508 ccomp function,hypothesized
R10090 T12513 T12512 prep by,function
R10091 T12514 T12513 pcomp inhibiting,by
R10092 T12515 T12517 compound RPS3,phosphorylation
R10093 T12516 T12517 compound S209,phosphorylation
R10094 T12517 T12514 dobj phosphorylation,inhibiting
R10095 T12518 T12508 punct .,hypothesized
R10096 T12519 T12520 mark As,expected
R10097 T12520 T12520 ROOT expected,expected
R10098 T12521 T12520 punct ",",expected
R10099 T12522 T12520 advcl transfecting,expected
R10100 T12523 T12524 amod increasing,amounts
R10101 T12524 T12522 dobj amounts,transfecting
R10102 T12525 T12524 prep of,amounts
R10103 T12526 T12527 amod NleH1-HA,plasmid
R10104 T12527 T12525 pobj plasmid,of
R10105 T12528 T12524 acl blocked,amounts
R10106 T12529 T12531 amod TNFα-induced,activation
R10107 T12530 T12531 compound NF-κB,activation
R10108 T12531 T12528 dobj activation,blocked
R10109 T12532 T12528 prep in,blocked
R10110 T12533 T12535 det a,manner
R10111 T12534 T12535 amod dose-dependent,manner
R10112 T12535 T12532 pobj manner,in
R10113 T12536 T12538 punct (,6a-b
R10114 T12537 T12538 compound Fig.,6a-b
R10115 T12538 T12535 appos 6a-b,manner
R10116 T12539 T12540 punct ),9
R10117 T12540 T12538 advmod 9,6a-b
R10118 T12541 T12520 punct .,expected
R10119 T12542 T12545 advmod Remarkably,reduced
R10120 T12543 T12545 punct ",",reduced
R10121 T12544 T12545 nsubj NleH1,reduced
R10122 T12545 T12545 ROOT reduced,reduced
R10123 T12546 T12554 det both,phosphorylation
R10124 T12547 T12554 amod TNF-induced,phosphorylation
R10125 T12548 T12547 punct ",",TNF-induced
R10126 T12549 T12551 advmod as,as
R10127 T12550 T12551 advmod well,as
R10128 T12551 T12547 cc as,TNF-induced
R10129 T12552 T12553 amod basal,RPS3
R10130 T12553 T12547 conj RPS3,TNF-induced
R10131 T12554 T12545 dobj phosphorylation,reduced
R10132 T12555 T12545 prep to,reduced
R10133 T12556 T12557 advmod roughly,20
R10134 T12557 T12558 nummod 20,%
R10135 T12558 T12555 pobj %,to
R10136 T12559 T12558 prep of,%
R10137 T12560 T12561 compound vehicle,control
R10138 T12561 T12559 pobj control,of
R10139 T12562 T12545 punct (,reduced
R10140 T12563 T12565 nmod Fig.,)
R10141 T12564 T12563 nummod 6c,Fig.
R10142 T12565 T12545 punct ),reduced
R10143 T12566 T12545 punct .,reduced
R10144 T12567 T12571 csubj Expressing,interfere
R10145 T12568 T12567 dobj NleH1,Expressing
R10146 T12569 T12571 aux does,interfere
R10147 T12570 T12571 neg not,interfere
R10148 T12571 T12571 ROOT interfere,interfere
R10149 T12572 T12571 prep with,interfere
R10150 T12573 T12576 det either,activation
R10151 T12574 T12576 amod TNF-induced,activation
R10152 T12575 T12576 compound IKK,activation
R10153 T12576 T12572 pobj activation,with
R10154 T12577 T12576 cc or,activation
R10155 T12578 T12576 conj IκBα,activation
R10156 T12579 T12576 conj degradation,activation
R10157 T12580 T12576 punct ",",activation
R10158 T12581 T12576 amod consistent,activation
R10159 T12582 T12581 prep with,consistent
R10160 T12583 T12584 det the,lack
R10161 T12584 T12582 pobj lack,with
R10162 T12585 T12584 prep of,lack
R10163 T12586 T12587 amod NleH1,impact
R10164 T12587 T12585 pobj impact,of
R10165 T12588 T12587 prep on,impact
R10166 T12589 T12591 nummod p65,translocation9
R10167 T12590 T12591 amod nuclear,translocation9
R10168 T12591 T12588 pobj translocation9,on
R10169 T12592 T12584 punct (,lack
R10170 T12593 T12584 appos Fig.,lack
R10171 T12594 T12593 nummod 6c,Fig.
R10172 T12595 T12584 punct ),lack
R10173 T12596 T12571 punct .,interfere
R10174 T12597 T12598 aux To,determine
R10175 T12598 T12606 advcl determine,infected
R10176 T12599 T12601 mark if,inhibits
R10177 T12600 T12601 nsubj NleH1,inhibits
R10178 T12601 T12606 advcl inhibits,infected
R10179 T12602 T12603 compound RPS3,phosphorylation
R10180 T12603 T12601 dobj phosphorylation,inhibits
R10181 T12604 T12606 punct ",",infected
R10182 T12605 T12606 nsubj we,infected
R10183 T12606 T12606 ROOT infected,infected
R10184 T12607 T12608 compound HeLa,cells
R10185 T12608 T12606 dobj cells,infected
R10186 T12609 T12606 prep with,infected
R10187 T12610 T12612 compound E.,O157
R10188 T12611 T12612 compound coli,O157
R10189 T12612 T12609 pobj O157,with
R10190 T12613 T12612 punct :,O157
R10191 T12614 T12615 compound H7,strains
R10192 T12615 T12612 appos strains,O157
R10193 T12616 T12615 acl possessing,strains
R10194 T12617 T12616 cc or,possessing
R10195 T12618 T12616 conj lacking,possessing
R10196 T12619 T12620 preconj either,nleH1
R10197 T12620 T12618 dobj nleH1,lacking
R10198 T12621 T12622 punct (,ΔnleH1
R10199 T12622 T12620 appos ΔnleH1,nleH1
R10200 T12623 T12622 punct ),ΔnleH1
R10201 T12624 T12620 cc or,nleH1
R10202 T12625 T12620 conj with,nleH1
R10203 T12626 T12627 det a,strain
R10204 T12627 T12625 pobj strain,with
R10205 T12628 T12627 acl lacking,strain
R10206 T12629 T12630 det a,functional
R10207 T12630 T12628 dobj functional,lacking
R10208 T12631 T12632 nummod T3SS,unable
R10209 T12632 T12630 amod unable,functional
R10210 T12633 T12634 aux to,inject
R10211 T12634 T12632 xcomp inject,unable
R10212 T12635 T12634 dobj NleH1,inject
R10213 T12636 T12634 prep into,inject
R10214 T12637 T12638 amod mammalian,cells
R10215 T12638 T12636 pobj cells,into
R10216 T12639 T12640 punct (,ΔescN
R10217 T12640 T12638 appos ΔescN,cells
R10218 T12641 T12630 punct ),functional
R10219 T12642 T12606 punct .,infected
R10220 T12643 T12648 prep In,stimulated
R10221 T12644 T12645 amod uninfected,cells
R10222 T12645 T12643 pobj cells,In
R10223 T12646 T12648 punct ",",stimulated
R10224 T12647 T12648 nsubj TNF-treatment,stimulated
R10225 T12648 T12648 ROOT stimulated,stimulated
R10226 T12649 T12652 det a,increase
R10227 T12650 T12652 amod ∼,increase
R10228 T12651 T12652 amod 7-fold,increase
R10229 T12652 T12648 dobj increase,stimulated
R10230 T12653 T12652 prep in,increase
R10231 T12654 T12656 compound RPS3,phosphorylation
R10232 T12655 T12656 compound S209,phosphorylation
R10233 T12656 T12653 pobj phosphorylation,in
R10234 T12657 T12648 punct ",",stimulated
R10235 T12658 T12648 advcl peaking,stimulated
R10236 T12659 T12658 prep at,peaking
R10237 T12660 T12661 nummod 30,minutes
R10238 T12661 T12659 pobj minutes,at
R10239 T12662 T12661 punct (,minutes
R10240 T12663 T12661 appos Fig.,minutes
R10241 T12664 T12663 nummod 6d,Fig.
R10242 T12665 T12661 punct ),minutes
R10243 T12666 T12648 punct .,stimulated
R10244 T12667 T12675 prep By,impaired
R10245 T12668 T12667 pobj contrast,By
R10246 T12669 T12675 punct ",",impaired
R10247 T12670 T12672 compound RPS3,phosphorylation
R10248 T12671 T12672 compound S209,phosphorylation
R10249 T12672 T12675 nsubjpass phosphorylation,impaired
R10250 T12673 T12675 auxpass was,impaired
R10251 T12674 T12675 advmod substantially,impaired
R10252 T12675 T12675 ROOT impaired,impaired
R10253 T12676 T12675 prep in,impaired
R10254 T12677 T12676 pobj cells,in
R10255 T12678 T12677 acl infected,cells
R10256 T12679 T12678 prep with,infected
R10257 T12680 T12683 amod wild-type,O157
R10258 T12681 T12683 compound E.,O157
R10259 T12682 T12683 compound coli,O157
R10260 T12683 T12679 pobj O157,with
R10261 T12684 T12675 punct :,impaired
R10262 T12685 T12685 ROOT H7,H7
R10263 T12686 T12687 punct (,Fig.
R10264 T12687 T12685 appos Fig.,H7
R10265 T12688 T12687 nummod 6d,Fig.
R10266 T12689 T12685 punct ),H7
R10267 T12690 T12685 punct .,H7
R10268 T12691 T12698 advmod However,unimpaired
R10269 T12692 T12698 punct ",",unimpaired
R10270 T12693 T12696 amod TNF-induced,phosphorylation
R10271 T12694 T12696 compound RPS3,phosphorylation
R10272 T12695 T12696 compound S209,phosphorylation
R10273 T12696 T12698 nsubjpass phosphorylation,unimpaired
R10274 T12697 T12698 auxpass was,unimpaired
R10275 T12698 T12698 ROOT unimpaired,unimpaired
R10276 T12699 T12698 prep in,unimpaired
R10277 T12700 T12699 pobj cells,in
R10278 T12701 T12700 acl infected,cells
R10279 T12702 T12701 prep with,infected
R10280 T12703 T12704 det either,ΔnleH1
R10281 T12704 T12702 pobj ΔnleH1,with
R10282 T12705 T12704 cc or,ΔnleH1
R10283 T12706 T12704 conj ΔescN,ΔnleH1
R10284 T12707 T12706 punct (,ΔescN
R10285 T12708 T12706 appos Fig.,ΔescN
R10286 T12709 T12708 nummod 6d,Fig.
R10287 T12710 T12706 punct ),ΔescN
R10288 T12711 T12698 punct .,unimpaired
R10289 T12712 T12713 nsubj We,showed
R10290 T12713 T12713 ROOT showed,showed
R10291 T12714 T12713 advmod previously,showed
R10292 T12715 T12716 mark that,wild-type
R10293 T12716 T12713 ccomp wild-type,showed
R10294 T12717 T12716 punct ",",wild-type
R10295 T12718 T12716 cc but,wild-type
R10296 T12719 T12720 neg not,ΔnleH1
R10297 T12720 T12716 conj ΔnleH1,wild-type
R10298 T12721 T12720 cc or,ΔnleH1
R10299 T12722 T12725 compound ΔescN,O157
R10300 T12723 T12725 compound E.,O157
R10301 T12724 T12725 compound coli,O157
R10302 T12725 T12720 conj O157,ΔnleH1
R10303 T12726 T12725 punct :,O157
R10304 T12727 T12729 nsubj H7,attenuated
R10305 T12728 T12729 advmod significantly,attenuated
R10306 T12729 T12729 ROOT attenuated,attenuated
R10307 T12730 T12733 amod TNF-induced,translocation9
R10308 T12731 T12733 amod RPS3,translocation9
R10309 T12732 T12733 amod nuclear,translocation9
R10310 T12733 T12729 dobj translocation9,attenuated
R10311 T12734 T12729 punct .,attenuated
R10312 T12735 T12736 det The,parallel
R10313 T12736 T12748 nsubj parallel,provides
R10314 T12737 T12736 prep between,parallel
R10315 T12738 T12739 nummod RPS3,phosphorylation
R10316 T12739 T12737 pobj phosphorylation,between
R10317 T12740 T12739 cc and,phosphorylation
R10318 T12741 T12743 poss its,translocation
R10319 T12742 T12743 amod nuclear,translocation
R10320 T12743 T12739 conj translocation,phosphorylation
R10321 T12744 T12743 prep during,translocation
R10322 T12745 T12746 compound E.,coli
R10323 T12746 T12747 compound coli,infection
R10324 T12747 T12744 pobj infection,during
R10325 T12748 T12748 ROOT provides,provides
R10326 T12749 T12748 dobj evidence,provides
R10327 T12750 T12748 prep in,provides
R10328 T12751 T12752 det the,context
R10329 T12752 T12750 pobj context,in
R10330 T12753 T12752 prep of,context
R10331 T12754 T12757 det an,process
R10332 T12755 T12757 amod NF-κB-dependent,process
R10333 T12756 T12757 compound disease,process
R10334 T12757 T12753 pobj process,of
R10335 T12758 T12762 mark that,is
R10336 T12759 T12761 compound RPS3,phosphorylation
R10337 T12760 T12761 compound S209,phosphorylation
R10338 T12761 T12762 nsubj phosphorylation,is
R10339 T12762 T12748 advcl is,provides
R10340 T12763 T12762 acomp important,is
R10341 T12764 T12763 prep for,important
R10342 T12765 T12766 amod nuclear,translocation
R10343 T12766 T12764 pobj translocation,for
R10344 T12767 T12748 punct .,provides
R10345 T12768 T12769 poss Our,discovery
R10346 T12769 T12776 nsubj discovery,suggested
R10347 T12770 T12772 mark that,inhibits
R10348 T12771 T12772 nsubj NleH1,inhibits
R10349 T12772 T12769 acl inhibits,discovery
R10350 T12773 T12775 compound RPS3,phosphorylation
R10351 T12774 T12775 compound S209,phosphorylation
R10352 T12775 T12776 nsubj phosphorylation,suggested
R10353 T12776 T12776 ROOT suggested,suggested
R10354 T12777 T12781 mark that,blocks
R10355 T12778 T12781 nsubj it,blocks
R10356 T12779 T12781 aux should,blocks
R10357 T12780 T12781 advmod also,blocks
R10358 T12781 T12776 ccomp blocks,suggested
R10359 T12782 T12786 nmod RPS3-dependent,transcription
R10360 T12783 T12786 compound NF-κB,transcription
R10361 T12784 T12786 compound target,transcription
R10362 T12785 T12786 compound gene,transcription
R10363 T12786 T12781 dobj transcription,blocks
R10364 T12787 T12789 punct (,IL8
R10365 T12788 T12789 nmod e.g.,IL8
R10366 T12789 T12791 nmod IL8,NFKBIA
R10367 T12790 T12791 punct ",",NFKBIA
R10368 T12791 T12781 conj NFKBIA,blocks
R10369 T12792 T12791 punct ",",NFKBIA
R10370 T12793 T12791 cc and,NFKBIA
R10371 T12794 T12791 conj TNFAIP3,NFKBIA
R10372 T12795 T12791 punct ),NFKBIA
R10373 T12796 T12776 punct .,suggested
R10374 T12797 T12801 advmod Indeed,were
R10375 T12798 T12801 punct ",",were
R10376 T12799 T12800 det these,genes
R10377 T12800 T12801 nsubj genes,were
R10378 T12801 T12801 ROOT were,were
R10379 T12802 T12803 advmod only,modestly
R10380 T12803 T12804 advmod modestly,upregulated
R10381 T12804 T12801 acomp upregulated,were
R10382 T12805 T12804 prep in,upregulated
R10383 T12806 T12805 pobj cells,in
R10384 T12807 T12806 acl infected,cells
R10385 T12808 T12807 prep with,infected
R10386 T12809 T12811 compound wild-type,coli
R10387 T12810 T12811 compound E.,coli
R10388 T12811 T12808 pobj coli,with
R10389 T12812 T12812 ROOT O157,O157
R10390 T12813 T12812 punct :,O157
R10391 T12814 T12818 nsubj H7,induced
R10392 T12815 T12814 punct ",",H7
R10393 T12816 T12814 cc but,H7
R10394 T12817 T12818 advmod significantly,induced
R10395 T12818 T12818 ROOT induced,induced
R10396 T12819 T12818 prep in,induced
R10397 T12820 T12819 pobj cells,in
R10398 T12821 T12820 acl infected,cells
R10399 T12822 T12821 prep with,infected
R10400 T12823 T12824 det either,ΔnleH1
R10401 T12824 T12827 nmod ΔnleH1,strains
R10402 T12825 T12824 cc or,ΔnleH1
R10403 T12826 T12824 conj ΔescN,ΔnleH1
R10404 T12827 T12822 pobj strains,with
R10405 T12828 T12818 punct (,induced
R10406 T12829 T12818 dobj Fig.,induced
R10407 T12830 T12829 nummod 6e,Fig.
R10408 T12831 T12829 punct ),Fig.
R10409 T12832 T12818 punct .,induced
R10410 T12833 T12838 prep In,had
R10411 T12834 T12833 pobj contrast,In
R10412 T12835 T12838 punct ",",had
R10413 T12836 T12838 advcl deleting,had
R10414 T12837 T12838 nsubj nleH1,had
R10415 T12838 T12838 ROOT had,had
R10416 T12839 T12840 det no,impact
R10417 T12840 T12838 dobj impact,had
R10418 T12841 T12840 prep on,impact
R10419 T12842 T12843 det the,expression
R10420 T12843 T12841 pobj expression,on
R10421 T12844 T12843 prep of,expression
R10423 T12846 T12844 pobj genes,of
R10424 T12847 T12846 punct ",",genes
R10425 T12848 T12846 prep including,genes
R10426 T12849 T12848 pobj CD25,including
R10427 T12850 T12849 cc and,CD25
R10428 T12851 T12849 conj TNFSF13B,CD25
R10429 T12852 T12851 punct (,TNFSF13B
R10430 T12853 T12854 compound Supplementary,Fig.
R10431 T12854 T12849 conj Fig.,CD25
R10432 T12855 T12854 nummod 12,Fig.
R10433 T12856 T12838 punct ),had
R10434 T12857 T12838 punct .,had
R10435 T12858 T12861 advmod Together,demonstrate
R10436 T12859 T12860 det these,results
R10437 T12860 T12861 nsubj results,demonstrate
R10438 T12861 T12861 ROOT demonstrate,demonstrate
R10439 T12862 T12865 mark that,inhibits
R10440 T12863 T12865 nsubj NleH1,inhibits
R10441 T12864 T12865 advmod specifically,inhibits
R10442 T12865 T12861 ccomp inhibits,demonstrate
R10443 T12866 T12869 det the,response
R10444 T12867 T12869 amod protective,response
R10445 T12868 T12869 amod immune,response
R10446 T12869 T12865 dobj response,inhibits
R10447 T12870 T12865 prep by,inhibits
R10448 T12871 T12872 advmod directly,blocking
R10449 T12872 T12870 pcomp blocking,by
R10450 T12873 T12875 compound RPS3,phosphorylation
R10451 T12874 T12875 compound S209,phosphorylation
R10452 T12875 T12872 dobj phosphorylation,blocking
R10453 T12876 T12872 cc and,blocking
R10454 T12877 T12878 advmod thereby,impairing
R10455 T12878 T12872 conj impairing,blocking
R10456 T12879 T12883 amod critical,genes
R10457 T12880 T12883 amod RPS3-dependent,genes
R10458 T12881 T12883 compound NF-κB,genes
R10459 T12882 T12883 compound target,genes
R10460 T12883 T12878 dobj genes,impairing
R10461 T12884 T12861 punct .,demonstrate
R10422 T12845 T12846 amod RPS3-independent,genes

UBERON-AE

Id Subject Object Predicate Lexical cue
T11828 208-218 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11829 208-229 http://purl.obolibrary.org/obo/UBERON_0001277 denotes intestinal epithelial

GO-BP

Id Subject Object Predicate Lexical cue
T13010 20-35 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13011 531-546 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13012 758-773 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13013 1033-1048 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13014 1320-1335 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13015 1393-1408 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13016 1527-1542 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13017 1784-1799 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13018 1941-1956 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13019 2041-2056 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13020 2636-2651 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13021 257-270 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibit NF-κB
T13022 257-270 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibit NF-κB
T13023 634-650 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T13024 879-882 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T13025 902-913 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T13026 2127-2140 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13027 2589-2604 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

GO-MF

Id Subject Object Predicate Lexical cue
T13028 879-882 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK

GO-CC

Id Subject Object Predicate Lexical cue
T13029 1067-1072 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13030 1227-1232 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13031 1256-1261 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13032 1439-1444 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13033 1561-1566 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13034 2228-2233 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13035 2304-2309 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T11937 0-44 Sentence denotes NleH1 inhibits RPS3 phosphorylation in vitro
T11938 45-147 Sentence denotes EHEC pathogens are important causative agents of both foodborne disease and pediatric renal failure31.
T11939 148-306 Sentence denotes EHEC utilize T3SS to inject effector proteins directly into intestinal epithelial cells32, a subset of which inhibit NF-κB-dependent innate responses9, 33-38.
T11940 307-456 Sentence denotes The E. coli O157:H7 EDL933 effector protein NleH1 binds to and attenuates RPS3 nuclear translocation, thus impairing RPS3-dependent NF-κB signaling9.
T11941 457-547 Sentence denotes We therefore hypothesized that NleH1 may function by inhibiting RPS3 S209 phosphorylation.
T11942 548-691 Sentence denotes As expected, transfecting increasing amounts of NleH1-HA plasmid blocked TNFα-induced NF-κB activation in a dose-dependent manner (Fig. 6a-b)9.
T11943 692-818 Sentence denotes Remarkably, NleH1 reduced both TNF-induced, as well as basal RPS3 phosphorylation to roughly 20% of vehicle control (Fig. 6c).
T11944 819-996 Sentence denotes Expressing NleH1 does not interfere with either TNF-induced IKK activation or IκBα degradation, consistent with the lack of NleH1 impact on p65 nuclear translocation9 (Fig. 6c).
T11945 997-1241 Sentence denotes To determine if NleH1 inhibits RPS3 phosphorylation, we infected HeLa cells with E. coli O157:H7 strains possessing or lacking either nleH1 (ΔnleH1) or with a strain lacking a functional T3SS unable to inject NleH1 into mammalian cells (ΔescN).
T11946 1242-1369 Sentence denotes In uninfected cells, TNF-treatment stimulated a ∼7-fold increase in RPS3 S209 phosphorylation, peaking at 30 minutes (Fig. 6d).
T11947 1370-1495 Sentence denotes By contrast, RPS3 S209 phosphorylation was substantially impaired in cells infected with wild-type E. coli O157:H7 (Fig. 6d).
T11948 1496-1614 Sentence denotes However, TNF-induced RPS3 S209 phosphorylation was unimpaired in cells infected with either ΔnleH1 or ΔescN (Fig. 6d).
T11949 1615-1757 Sentence denotes We showed previously that wild-type, but not ΔnleH1 or ΔescN E. coli O157:H7 significantly attenuated TNF-induced RPS3 nuclear translocation9.
T11950 1758-1996 Sentence denotes The parallel between RPS3 phosphorylation and its nuclear translocation during E. coli infection provides evidence in the context of an NF-κB-dependent disease process that RPS3 S209 phosphorylation is important for nuclear translocation.
T11951 1997-2173 Sentence denotes Our discovery that NleH1 inhibits RPS3 S209 phosphorylation suggested that it should also blocks RPS3-dependent NF-κB target gene transcription (e.g. IL8, NFKBIA, and TNFAIP3).
T11952 2174-2365 Sentence denotes Indeed, these genes were only modestly upregulated in cells infected with wild-type E. coli O157:H7, but significantly induced in cells infected with either ΔnleH1 or ΔescN strains (Fig. 6e).
T11953 2366-2505 Sentence denotes In contrast, deleting nleH1 had no impact on the expression of RPS3-independent genes, including CD25 and TNFSF13B (Supplementary Fig. 12).
T11954 2506-2717 Sentence denotes Together these results demonstrate that NleH1 specifically inhibits the protective immune response by directly blocking RPS3 S209 phosphorylation and thereby impairing critical RPS3-dependent NF-κB target genes.
T109 0-44 Sentence denotes NleH1 inhibits RPS3 phosphorylation in vitro
T110 45-147 Sentence denotes EHEC pathogens are important causative agents of both foodborne disease and pediatric renal failure31.
T111 148-306 Sentence denotes EHEC utilize T3SS to inject effector proteins directly into intestinal epithelial cells32, a subset of which inhibit NF-κB-dependent innate responses9, 33-38.
T112 307-456 Sentence denotes The E. coli O157:H7 EDL933 effector protein NleH1 binds to and attenuates RPS3 nuclear translocation, thus impairing RPS3-dependent NF-κB signaling9.
T113 457-547 Sentence denotes We therefore hypothesized that NleH1 may function by inhibiting RPS3 S209 phosphorylation.
T114 548-691 Sentence denotes As expected, transfecting increasing amounts of NleH1-HA plasmid blocked TNFα-induced NF-κB activation in a dose-dependent manner (Fig. 6a-b)9.
T115 692-818 Sentence denotes Remarkably, NleH1 reduced both TNF-induced, as well as basal RPS3 phosphorylation to roughly 20% of vehicle control (Fig. 6c).
T116 819-996 Sentence denotes Expressing NleH1 does not interfere with either TNF-induced IKK activation or IκBα degradation, consistent with the lack of NleH1 impact on p65 nuclear translocation9 (Fig. 6c).
T117 997-1241 Sentence denotes To determine if NleH1 inhibits RPS3 phosphorylation, we infected HeLa cells with E. coli O157:H7 strains possessing or lacking either nleH1 (ΔnleH1) or with a strain lacking a functional T3SS unable to inject NleH1 into mammalian cells (ΔescN).
T118 1242-1369 Sentence denotes In uninfected cells, TNF-treatment stimulated a ∼7-fold increase in RPS3 S209 phosphorylation, peaking at 30 minutes (Fig. 6d).
T119 1370-1495 Sentence denotes By contrast, RPS3 S209 phosphorylation was substantially impaired in cells infected with wild-type E. coli O157:H7 (Fig. 6d).
T120 1496-1614 Sentence denotes However, TNF-induced RPS3 S209 phosphorylation was unimpaired in cells infected with either ΔnleH1 or ΔescN (Fig. 6d).
T121 1615-1757 Sentence denotes We showed previously that wild-type, but not ΔnleH1 or ΔescN E. coli O157:H7 significantly attenuated TNF-induced RPS3 nuclear translocation9.
T122 1758-1996 Sentence denotes The parallel between RPS3 phosphorylation and its nuclear translocation during E. coli infection provides evidence in the context of an NF-κB-dependent disease process that RPS3 S209 phosphorylation is important for nuclear translocation.
T123 1997-2173 Sentence denotes Our discovery that NleH1 inhibits RPS3 S209 phosphorylation suggested that it should also blocks RPS3-dependent NF-κB target gene transcription (e.g. IL8, NFKBIA, and TNFAIP3).
T124 2174-2365 Sentence denotes Indeed, these genes were only modestly upregulated in cells infected with wild-type E. coli O157:H7, but significantly induced in cells infected with either ΔnleH1 or ΔescN strains (Fig. 6e).
T125 2366-2505 Sentence denotes In contrast, deleting nleH1 had no impact on the expression of RPS3-independent genes, including CD25 and TNFSF13B (Supplementary Fig. 12).
T126 2506-2717 Sentence denotes Together these results demonstrate that NleH1 specifically inhibits the protective immune response by directly blocking RPS3 S209 phosphorylation and thereby impairing critical RPS3-dependent NF-κB target genes.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T13458 0-5 Protein denotes NleH1
T13459 6-14 Negative_regulation denotes inhibits
T13460 15-19 Protein denotes RPS3
T13461 20-35 Phosphorylation denotes phosphorylation
T13462 351-356 Protein denotes NleH1
T13463 357-362 Binding denotes binds
T13464 370-380 Negative_regulation denotes attenuates
T13465 381-385 Protein denotes RPS3
T13466 386-393 Entity denotes nuclear
T13467 394-407 Localization denotes translocation
T13468 424-428 Protein denotes RPS3
T13469 488-493 Protein denotes NleH1
T13470 510-520 Negative_regulation denotes inhibiting
T13471 521-525 Protein denotes RPS3
T13472 526-530 Entity denotes S209
T13473 531-546 Phosphorylation denotes phosphorylation
T13474 574-584 Positive_regulation denotes increasing
T13475 596-604 Protein denotes NleH1-HA
T13476 621-625 Protein denotes TNFα
T13477 704-709 Protein denotes NleH1
T13478 710-717 Negative_regulation denotes reduced
T13479 710-717 Negative_regulation denotes reduced
T13480 723-726 Protein denotes TNF
T13481 727-734 Positive_regulation denotes induced
T13482 753-757 Protein denotes RPS3
T13483 758-773 Phosphorylation denotes phosphorylation
T13484 819-829 Gene_expression denotes Expressing
T13485 830-835 Protein denotes NleH1
T13486 845-854 Negative_regulation denotes interfere
T13487 845-854 Negative_regulation denotes interfere
T13488 867-870 Protein denotes TNF
T13489 883-893 Positive_regulation denotes activation
T13490 897-901 Protein denotes IκBα
T13491 902-913 Protein_catabolism denotes degradation
T13492 935-939 Negative_regulation denotes lack
T13493 943-948 Protein denotes NleH1
T13494 949-955 Regulation denotes impact
T13495 959-962 Protein denotes p65
T13496 963-970 Entity denotes nuclear
T13497 971-984 Localization denotes translocation
T13498 1013-1018 Protein denotes NleH1
T13499 1019-1027 Negative_regulation denotes inhibits true
T13500 1028-1032 Protein denotes RPS3
T13501 1033-1048 Phosphorylation denotes phosphorylation
T13502 1116-1123 Negative_regulation denotes lacking
T13503 1131-1136 Protein denotes nleH1
T13504 1138-1144 Protein denotes ΔnleH1
T13505 1206-1211 Protein denotes NleH1
T13506 1234-1239 Protein denotes ΔescN
T13507 1263-1266 Protein denotes TNF
T13508 1298-1306 Positive_regulation denotes increase
T13509 1310-1314 Protein denotes RPS3
T13510 1315-1319 Entity denotes S209
T13511 1320-1335 Phosphorylation denotes phosphorylation
T13512 1383-1387 Protein denotes RPS3
T13513 1388-1392 Entity denotes S209
T13514 1393-1408 Phosphorylation denotes phosphorylation
T13515 1427-1435 Negative_regulation denotes impaired
T13516 1505-1508 Protein denotes TNF
T13517 1509-1516 Positive_regulation denotes induced
T13518 1517-1521 Protein denotes RPS3
T13519 1522-1526 Entity denotes S209
T13520 1527-1542 Phosphorylation denotes phosphorylation
T13521 1547-1557 Negative_regulation denotes unimpaired true
T13522 1547-1557 Negative_regulation denotes unimpaired true
T13523 1588-1594 Protein denotes ΔnleH1
T13524 1598-1603 Protein denotes ΔescN
T13525 1660-1666 Protein denotes ΔnleH1
T13526 1670-1675 Protein denotes ΔescN
T13527 1706-1716 Negative_regulation denotes attenuated
T13528 1706-1716 Negative_regulation denotes attenuated
T13529 1717-1720 Protein denotes TNF
T13530 1721-1728 Positive_regulation denotes induced
T13531 1729-1733 Protein denotes RPS3
T13532 1734-1741 Entity denotes nuclear
T13533 1742-1755 Localization denotes translocation
T13534 1779-1783 Protein denotes RPS3
T13535 1784-1799 Phosphorylation denotes phosphorylation
T13536 1808-1815 Entity denotes nuclear
T13537 1816-1829 Localization denotes translocation
T13538 1931-1935 Protein denotes RPS3
T13539 1936-1940 Entity denotes S209
T13540 1941-1956 Phosphorylation denotes phosphorylation
T13541 1960-1969 Regulation denotes important
T13542 1974-1981 Entity denotes nuclear
T13543 1982-1995 Localization denotes translocation
T13544 2016-2021 Protein denotes NleH1
T13545 2022-2030 Negative_regulation denotes inhibits
T13546 2031-2035 Protein denotes RPS3
T13547 2036-2040 Entity denotes S209
T13548 2041-2056 Phosphorylation denotes phosphorylation
T13549 2094-2098 Protein denotes RPS3
T13550 2147-2150 Protein denotes IL8
T13551 2152-2158 Protein denotes NFKBIA
T13552 2164-2171 Protein denotes TNFAIP3
T13553 2331-2337 Protein denotes ΔnleH1
T13554 2341-2346 Protein denotes ΔescN
T13555 2379-2387 Negative_regulation denotes deleting
T13556 2388-2393 Protein denotes nleH1
T13557 2463-2467 Protein denotes CD25
T13558 2472-2480 Protein denotes TNFSF13B
T13559 2546-2551 Protein denotes NleH1
T13560 2617-2625 Negative_regulation denotes blocking
T13561 2626-2630 Protein denotes RPS3
T13562 2631-2635 Entity denotes S209
T13563 2636-2651 Phosphorylation denotes phosphorylation
T13564 2683-2687 Protein denotes RPS3
R10816 T13458 T13459 causeOf NleH1,inhibits
R10817 T13460 T13461 themeOf RPS3,phosphorylation
R10818 T13461 T13459 themeOf phosphorylation,inhibits
R10819 T13462 T13463 themeOf NleH1,binds
R10820 T13463 T13464 causeOf binds,attenuates
R10821 T13465 T13467 themeOf RPS3,translocation
R10822 T13465 T13463 themeOf RPS3,binds
R10823 T13466 T13467 locationOf nuclear,translocation
R10824 T13467 T13464 themeOf translocation,attenuates
R10825 T13469 T13470 causeOf NleH1,inhibiting
R10826 T13472 T13473 themeOf S209,phosphorylation
R10827 T13472 T13471 partOf S209,RPS3
R10828 T13473 T13470 themeOf phosphorylation,inhibiting
R10829 T13475 T13474 themeOf NleH1-HA,increasing
R10830 T13477 T13479 causeOf NleH1,reduced
R10831 T13477 T13478 causeOf NleH1,reduced
R10832 T13480 T13481 causeOf TNF,induced
R10833 T13481 T13479 themeOf induced,reduced
R10834 T13482 T13483 themeOf RPS3,phosphorylation
R10835 T13483 T13481 themeOf phosphorylation,induced
R10836 T13483 T13478 themeOf phosphorylation,reduced
R10837 T13484 T13487 causeOf Expressing,interfere
R10838 T13484 T13489 themeOf Expressing,activation
R10839 T13484 T13486 causeOf Expressing,interfere
R10840 T13485 T13484 themeOf NleH1,Expressing
R10841 T13488 T13489 causeOf TNF,activation
R10842 T13489 T13487 themeOf activation,interfere
R10843 T13490 T13491 themeOf IκBα,degradation
R10844 T13491 T13486 themeOf degradation,interfere
R10845 T13492 T13494 causeOf lack,impact
R10846 T13493 T13492 themeOf NleH1,lack
R10847 T13495 T13497 themeOf p65,translocation
R10848 T13496 T13497 locationOf nuclear,translocation
R10849 T13497 T13494 themeOf translocation,impact
R10850 T13498 T13499 causeOf NleH1,inhibits
R10851 T13500 T13501 themeOf RPS3,phosphorylation
R10852 T13501 T13499 themeOf phosphorylation,inhibits
R10853 T13503 T13502 themeOf nleH1,lacking
R10854 T13507 T13508 causeOf TNF,increase
R10855 T13510 T13511 themeOf S209,phosphorylation
R10856 T13510 T13509 partOf S209,RPS3
R10857 T13511 T13508 themeOf phosphorylation,increase
R10858 T13513 T13514 themeOf S209,phosphorylation
R10859 T13513 T13512 partOf S209,RPS3
R10860 T13514 T13515 themeOf phosphorylation,impaired
R10861 T13516 T13517 causeOf TNF,induced
R10862 T13517 T13521 themeOf induced,unimpaired
R10863 T13517 T13522 themeOf induced,unimpaired
R10864 T13519 T13520 themeOf S209,phosphorylation
R10865 T13519 T13518 partOf S209,RPS3
R10866 T13520 T13517 themeOf phosphorylation,induced
R10867 T13523 T13521 causeOf ΔnleH1,unimpaired
R10868 T13524 T13522 causeOf ΔescN,unimpaired
R10869 T13525 T13527 causeOf ΔnleH1,attenuated
R10870 T13526 T13528 causeOf ΔescN,attenuated
R10871 T13529 T13530 causeOf TNF,induced
R10872 T13530 T13527 themeOf induced,attenuated
R10873 T13530 T13528 themeOf induced,attenuated
R10874 T13531 T13533 themeOf RPS3,translocation
R10875 T13532 T13533 locationOf nuclear,translocation
R10876 T13533 T13530 themeOf translocation,induced
R10877 T13534 T13535 themeOf RPS3,phosphorylation
R10878 T13534 T13537 themeOf RPS3,translocation
R10879 T13536 T13537 locationOf nuclear,translocation
R10880 T13538 T13543 themeOf RPS3,translocation
R10881 T13539 T13540 themeOf S209,phosphorylation
R10882 T13539 T13538 partOf S209,RPS3
R10883 T13540 T13541 causeOf phosphorylation,important
R10884 T13542 T13543 locationOf nuclear,translocation
R10885 T13543 T13541 themeOf translocation,important
R10886 T13544 T13545 causeOf NleH1,inhibits
R10887 T13547 T13548 themeOf S209,phosphorylation
R10888 T13547 T13546 partOf S209,RPS3
R10889 T13548 T13545 themeOf phosphorylation,inhibits
R10890 T13556 T13555 themeOf nleH1,deleting
R10891 T13559 T13560 causeOf NleH1,blocking
R10892 T13562 T13563 themeOf S209,phosphorylation
R10893 T13562 T13561 partOf S209,RPS3
R10894 T13563 T13560 themeOf phosphorylation,blocking

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T13037 20-35 Phosphorylation denotes phosphorylation
T13038 6-14 Negative_regulation denotes inhibits
T13039 45-49 Protein denotes EHEC
T13040 265-270 Protein denotes NF-κB
T13041 311-323 Protein denotes E. coli O157
T13042 324-333 Protein denotes H7 EDL933
T13043 351-356 Protein denotes NleH1
T13044 381-385 Protein denotes RPS3
T13045 424-428 Protein denotes RPS3
T13046 439-455 Protein denotes NF-κB signaling9
T13047 357-362 Binding denotes binds
T13048 357-362 Binding denotes binds
T13049 357-362 Binding denotes binds
T13050 386-393 Entity denotes nuclear
T13051 394-407 Localization denotes translocation
T13052 429-438 Positive_regulation denotes dependent
T13053 414-423 Negative_regulation denotes impairing
T13054 488-493 Protein denotes NleH1
T13055 521-530 Protein denotes RPS3 S209
T13056 531-546 Phosphorylation denotes phosphorylation
T13057 510-520 Negative_regulation denotes inhibiting
T13058 596-612 Protein denotes NleH1-HA plasmid
T13059 621-625 Protein denotes TNFα
T13060 634-639 Protein denotes NF-κB
T13061 704-709 Protein denotes NleH1
T13062 723-726 Protein denotes TNF
T13063 753-757 Protein denotes RPS3
T13064 809-816 Protein denotes Fig. 6c
T13065 758-773 Phosphorylation denotes phosphorylation
T13066 727-734 Positive_regulation denotes induced
T13067 710-717 Negative_regulation denotes reduced
T13068 830-835 Protein denotes NleH1
T13069 867-870 Protein denotes TNF
T13070 879-882 Protein denotes IKK
T13071 897-901 Protein denotes IκBα
T13072 943-948 Protein denotes NleH1
T13073 959-985 Protein denotes p65 nuclear translocation9
T13074 987-994 Protein denotes Fig. 6c
T13075 819-829 Gene_expression denotes Expressing
T13076 902-913 Protein_catabolism denotes degradation
T13077 935-939 Negative_regulation denotes lack
T13078 935-939 Negative_regulation denotes lack
T13079 935-939 Negative_regulation denotes lack
T13080 1013-1018 Protein denotes NleH1
T13081 1028-1032 Protein denotes RPS3
T13082 1131-1136 Protein denotes nleH1
T13083 1138-1144 Protein denotes ΔnleH1
T13084 1206-1211 Protein denotes NleH1
T13085 1033-1048 Phosphorylation denotes phosphorylation
T13086 1116-1123 Negative_regulation denotes lacking
T13087 1116-1123 Negative_regulation denotes lacking
T13088 1019-1027 Negative_regulation denotes inhibits
T13089 1263-1266 Protein denotes TNF
T13090 1310-1319 Protein denotes RPS3 S209
T13091 1320-1335 Phosphorylation denotes phosphorylation
T13092 1298-1306 Positive_regulation denotes increase
T13093 1383-1392 Protein denotes RPS3 S209
T13094 1393-1408 Phosphorylation denotes phosphorylation
T13095 1427-1435 Negative_regulation denotes impaired
T13096 1505-1508 Protein denotes TNF
T13097 1517-1526 Protein denotes RPS3 S209
T13098 1588-1603 Protein denotes ΔnleH1 or ΔescN
T13099 1605-1612 Protein denotes Fig. 6d
T13100 1527-1542 Phosphorylation denotes phosphorylation
T13101 1509-1516 Positive_regulation denotes induced
T13102 1547-1557 Negative_regulation denotes unimpaired
T13103 1660-1666 Protein denotes ΔnleH1
T13104 1670-1691 Protein denotes ΔescN E. coli O157:H7
T13105 1717-1720 Protein denotes TNF
T13106 1729-1733 Protein denotes RPS3
T13107 1734-1741 Entity denotes nuclear
T13108 1742-1756 Localization denotes translocation9
T13109 1721-1728 Positive_regulation denotes induced
T13110 1706-1716 Negative_regulation denotes attenuated
T13111 1706-1716 Negative_regulation denotes attenuated
T13112 1779-1783 Protein denotes RPS3
T13113 1894-1899 Protein denotes NF-κB
T13114 1931-1940 Protein denotes RPS3 S209
T13115 1784-1799 Phosphorylation denotes phosphorylation
T13116 1808-1815 Entity denotes nuclear
T13117 1816-1829 Localization denotes translocation
T13118 1941-1956 Phosphorylation denotes phosphorylation
T13119 1974-1981 Entity denotes nuclear
T13120 2016-2021 Protein denotes NleH1
T13121 2031-2040 Protein denotes RPS3 S209
T13122 2094-2098 Protein denotes RPS3
T13123 2109-2114 Protein denotes NF-κB
T13124 2147-2150 Protein denotes IL8
T13125 2152-2158 Protein denotes NFKBIA
T13126 2164-2171 Protein denotes TNFAIP3
T13127 2041-2056 Phosphorylation denotes phosphorylation
T13128 2127-2140 Transcription denotes transcription
T13129 2127-2140 Transcription denotes transcription
T13130 2127-2140 Transcription denotes transcription
T13131 2127-2140 Transcription denotes transcription
T13132 2022-2030 Negative_regulation denotes inhibits
T13133 2087-2093 Negative_regulation denotes blocks
T13134 2087-2093 Negative_regulation denotes blocks
T13135 2087-2093 Negative_regulation denotes blocks
T13136 2087-2093 Negative_regulation denotes blocks
T13137 2099-2108 Positive_regulation denotes dependent
T13138 2099-2108 Positive_regulation denotes dependent
T13139 2099-2108 Positive_regulation denotes dependent
T13140 2099-2108 Positive_regulation denotes dependent
T13141 2388-2393 Protein denotes nleH1
T13142 2429-2433 Protein denotes RPS3
T13143 2463-2467 Protein denotes CD25
T13144 2472-2480 Protein denotes TNFSF13B
T13145 2415-2425 Gene_expression denotes expression
T13146 2415-2425 Gene_expression denotes expression
T13147 2415-2425 Gene_expression denotes expression
T13148 2546-2551 Protein denotes NleH1
T13149 2626-2635 Protein denotes RPS3 S209
T13150 2683-2703 Protein denotes RPS3-dependent NF-κB
T13151 2636-2651 Phosphorylation denotes phosphorylation
T13152 2664-2673 Negative_regulation denotes impairing
T13153 2617-2625 Negative_regulation denotes blocking
T13036 15-19 Protein denotes RPS3
R10541 T13036 T13037 themeOf RPS3,phosphorylation
R10542 T13037 T13038 themeOf phosphorylation,inhibits
R10543 T13041 T13047 themeOf E. coli O157,binds
R10544 T13042 T13048 themeOf H7 EDL933,binds
R10545 T13043 T13049 themeOf NleH1,binds
R10546 T13044 T13051 themeOf RPS3,translocation
R10547 T13045 T13052 causeOf RPS3,dependent
R10548 T13046 T13052 themeOf NF-κB signaling9,dependent
R10549 T13050 T13051 locationOf nuclear,translocation
R10550 T13052 T13053 themeOf dependent,impairing
R10551 T13054 T13057 causeOf NleH1,inhibiting
R10552 T13055 T13056 themeOf RPS3 S209,phosphorylation
R10553 T13056 T13057 themeOf phosphorylation,inhibiting
R10554 T13061 T13067 causeOf NleH1,reduced
R10555 T13062 T13066 causeOf TNF,induced
R10556 T13063 T13065 themeOf RPS3,phosphorylation
R10557 T13065 T13066 themeOf phosphorylation,induced
R10558 T13066 T13067 themeOf induced,reduced
R10559 T13068 T13075 themeOf NleH1,Expressing
R10560 T13071 T13076 themeOf IκBα,degradation
R10561 T13072 T13077 themeOf NleH1,lack
R10562 T13073 T13078 themeOf p65 nuclear translocation9,lack
R10563 T13074 T13079 themeOf Fig. 6c,lack
R10564 T13080 T13088 causeOf NleH1,inhibits
R10565 T13081 T13085 themeOf RPS3,phosphorylation
R10566 T13082 T13086 themeOf nleH1,lacking
R10567 T13083 T13087 themeOf ΔnleH1,lacking
R10568 T13085 T13088 themeOf phosphorylation,inhibits
R10569 T13090 T13091 themeOf RPS3 S209,phosphorylation
R10570 T13091 T13092 themeOf phosphorylation,increase
R10571 T13093 T13094 themeOf RPS3 S209,phosphorylation
R10572 T13094 T13095 themeOf phosphorylation,impaired
R10573 T13096 T13101 causeOf TNF,induced
R10574 T13097 T13100 themeOf RPS3 S209,phosphorylation
R10575 T13100 T13101 themeOf phosphorylation,induced
R10576 T13101 T13102 themeOf induced,unimpaired
R10577 T13103 T13110 causeOf ΔnleH1,attenuated
R10578 T13104 T13111 causeOf ΔescN E. coli O157:H7,attenuated
R10579 T13105 T13109 causeOf TNF,induced
R10580 T13106 T13108 themeOf RPS3,translocation9
R10581 T13107 T13108 locationOf nuclear,translocation9
R10582 T13108 T13109 themeOf translocation9,induced
R10583 T13109 T13110 themeOf induced,attenuated
R10584 T13109 T13111 themeOf induced,attenuated
R10585 T13112 T13115 themeOf RPS3,phosphorylation
R10586 T13112 T13117 themeOf RPS3,translocation
R10587 T13114 T13118 themeOf RPS3 S209,phosphorylation
R10588 T13116 T13117 locationOf nuclear,translocation
R10589 T13120 T13132 causeOf NleH1,inhibits
R10590 T13121 T13127 themeOf RPS3 S209,phosphorylation
R10591 T13122 T13137 causeOf RPS3,dependent
R10592 T13122 T13138 causeOf RPS3,dependent
R10593 T13122 T13139 causeOf RPS3,dependent
R10594 T13122 T13140 causeOf RPS3,dependent
R10595 T13123 T13128 themeOf NF-κB,transcription
R10596 T13124 T13129 themeOf IL8,transcription
R10597 T13125 T13130 themeOf NFKBIA,transcription
R10598 T13126 T13131 themeOf TNFAIP3,transcription
R10599 T13127 T13132 themeOf phosphorylation,inhibits
R10600 T13128 T13133 themeOf transcription,blocks
R10601 T13128 T13137 themeOf transcription,dependent
R10602 T13129 T13134 themeOf transcription,blocks
R10603 T13129 T13138 themeOf transcription,dependent
R10604 T13130 T13135 themeOf transcription,blocks
R10605 T13130 T13139 themeOf transcription,dependent
R10606 T13131 T13136 themeOf transcription,blocks
R10607 T13131 T13140 themeOf transcription,dependent
R10608 T13142 T13145 themeOf RPS3,expression
R10609 T13143 T13146 themeOf CD25,expression
R10610 T13144 T13147 themeOf TNFSF13B,expression
R10611 T13148 T13152 causeOf NleH1,impairing
R10612 T13149 T13151 themeOf RPS3 S209,phosphorylation
R10613 T13150 T13152 themeOf RPS3-dependent NF-κB,impairing
R10614 T13151 T13153 themeOf phosphorylation,blocking

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T11830 0-5 Protein denotes NleH1
T11831 6-14 Negative_regulation denotes inhibits
T11832 15-19 Protein denotes RPS3
T11833 20-35 Phosphorylation denotes phosphorylation
T11834 351-356 Protein denotes NleH1
T11835 357-362 Binding denotes binds
T11836 370-380 Negative_regulation denotes attenuates
T11837 381-385 Protein denotes RPS3
T11838 386-393 Entity denotes nuclear
T11839 394-407 Localization denotes translocation
T11840 424-428 Protein denotes RPS3
T11841 488-493 Protein denotes NleH1
T11842 510-520 Negative_regulation denotes inhibiting
T11843 521-525 Protein denotes RPS3
T11844 526-530 Entity denotes S209
T11845 531-546 Phosphorylation denotes phosphorylation
T11846 574-584 Positive_regulation denotes increasing
T11847 596-604 Protein denotes NleH1-HA
T11848 621-625 Protein denotes TNFα
T11849 704-709 Protein denotes NleH1
T11850 710-717 Negative_regulation denotes reduced
T11851 710-717 Negative_regulation denotes reduced
T11852 723-726 Protein denotes TNF
T11853 727-734 Positive_regulation denotes induced
T11854 753-757 Protein denotes RPS3
T11855 758-773 Phosphorylation denotes phosphorylation
T11856 819-829 Gene_expression denotes Expressing
T11857 830-835 Protein denotes NleH1
T11858 845-854 Negative_regulation denotes interfere
T11859 845-854 Negative_regulation denotes interfere
T11860 867-870 Protein denotes TNF
T11861 883-893 Positive_regulation denotes activation
T11862 897-901 Protein denotes IκBα
T11863 902-913 Protein_catabolism denotes degradation
T11864 935-939 Negative_regulation denotes lack
T11865 943-948 Protein denotes NleH1
T11866 949-955 Regulation denotes impact
T11867 959-962 Protein denotes p65
T11868 963-970 Entity denotes nuclear
T11869 971-984 Localization denotes translocation
T11870 1013-1018 Protein denotes NleH1
T11871 1019-1027 Negative_regulation denotes inhibits true
T11872 1028-1032 Protein denotes RPS3
T11873 1033-1048 Phosphorylation denotes phosphorylation
T11874 1116-1123 Negative_regulation denotes lacking
T11875 1131-1136 Protein denotes nleH1
T11876 1138-1144 Protein denotes ΔnleH1
T11877 1206-1211 Protein denotes NleH1
T11878 1234-1239 Protein denotes ΔescN
T11879 1263-1266 Protein denotes TNF
T11880 1298-1306 Positive_regulation denotes increase
T11881 1310-1314 Protein denotes RPS3
T11882 1315-1319 Entity denotes S209
T11883 1320-1335 Phosphorylation denotes phosphorylation
T11884 1383-1387 Protein denotes RPS3
T11885 1388-1392 Entity denotes S209
T11886 1393-1408 Phosphorylation denotes phosphorylation
T11887 1427-1435 Negative_regulation denotes impaired
T11888 1505-1508 Protein denotes TNF
T11889 1509-1516 Positive_regulation denotes induced
T11890 1517-1521 Protein denotes RPS3
T11891 1522-1526 Entity denotes S209
T11892 1527-1542 Phosphorylation denotes phosphorylation
T11893 1547-1557 Negative_regulation denotes unimpaired true
T11894 1547-1557 Negative_regulation denotes unimpaired true
T11895 1588-1594 Protein denotes ΔnleH1
T11896 1598-1603 Protein denotes ΔescN
T11897 1660-1666 Protein denotes ΔnleH1
T11898 1670-1675 Protein denotes ΔescN
T11899 1706-1716 Negative_regulation denotes attenuated
T11900 1706-1716 Negative_regulation denotes attenuated
T11901 1717-1720 Protein denotes TNF
T11902 1721-1728 Positive_regulation denotes induced
T11903 1729-1733 Protein denotes RPS3
T11904 1734-1741 Entity denotes nuclear
T11905 1742-1755 Localization denotes translocation
T11906 1779-1783 Protein denotes RPS3
T11907 1784-1799 Phosphorylation denotes phosphorylation
T11908 1808-1815 Entity denotes nuclear
T11909 1816-1829 Localization denotes translocation
T11910 1931-1935 Protein denotes RPS3
T11911 1936-1940 Entity denotes S209
T11912 1941-1956 Phosphorylation denotes phosphorylation
T11913 1960-1969 Regulation denotes important
T11914 1974-1981 Entity denotes nuclear
T11915 1982-1995 Localization denotes translocation
T11916 2016-2021 Protein denotes NleH1
T11917 2022-2030 Negative_regulation denotes inhibits
T11918 2031-2035 Protein denotes RPS3
T11919 2036-2040 Entity denotes S209
T11920 2041-2056 Phosphorylation denotes phosphorylation
T11921 2094-2098 Protein denotes RPS3
T11922 2147-2150 Protein denotes IL8
T11923 2152-2158 Protein denotes NFKBIA
T11924 2164-2171 Protein denotes TNFAIP3
T11925 2331-2337 Protein denotes ΔnleH1
T11926 2341-2346 Protein denotes ΔescN
T11927 2379-2387 Negative_regulation denotes deleting
T11928 2388-2393 Protein denotes nleH1
T11929 2463-2467 Protein denotes CD25
T11930 2472-2480 Protein denotes TNFSF13B
T11931 2546-2551 Protein denotes NleH1
T11932 2617-2625 Negative_regulation denotes blocking
T11933 2626-2630 Protein denotes RPS3
T11934 2631-2635 Entity denotes S209
T11935 2636-2651 Phosphorylation denotes phosphorylation
T11936 2683-2687 Protein denotes RPS3
R9503 T11830 T11831 causeOf NleH1,inhibits
R9504 T11832 T11833 themeOf RPS3,phosphorylation
R9505 T11833 T11831 themeOf phosphorylation,inhibits
R9506 T11834 T11835 themeOf NleH1,binds
R9507 T11835 T11836 causeOf binds,attenuates
R9509 T11837 T11835 themeOf RPS3,binds
R9511 T11839 T11836 themeOf translocation,attenuates
R9512 T11841 T11842 causeOf NleH1,inhibiting
R9513 T11844 T11845 themeOf S209,phosphorylation
R9514 T11844 T11843 partOf S209,RPS3
R9516 T11847 T11846 themeOf NleH1-HA,increasing
R9517 T11849 T11851 causeOf NleH1,reduced
R9518 T11849 T11850 causeOf NleH1,reduced
R9519 T11852 T11853 causeOf TNF,induced
R9520 T11853 T11851 themeOf induced,reduced
R9521 T11854 T11855 themeOf RPS3,phosphorylation
R9522 T11855 T11853 themeOf phosphorylation,induced
R9523 T11855 T11850 themeOf phosphorylation,reduced
R9524 T11856 T11859 causeOf Expressing,interfere
R9525 T11856 T11861 themeOf Expressing,activation
R9526 T11856 T11858 causeOf Expressing,interfere
R9527 T11857 T11856 themeOf NleH1,Expressing
R9528 T11860 T11861 causeOf TNF,activation
R9529 T11861 T11859 themeOf activation,interfere
R9530 T11862 T11863 themeOf IκBα,degradation
R9531 T11863 T11858 themeOf degradation,interfere
R9532 T11864 T11866 causeOf lack,impact
R9533 T11865 T11864 themeOf NleH1,lack
R9534 T11867 T11869 themeOf p65,translocation
R9535 T11868 T11869 locationOf nuclear,translocation
R9536 T11869 T11866 themeOf translocation,impact
R9537 T11870 T11871 causeOf NleH1,inhibits
R9538 T11872 T11873 themeOf RPS3,phosphorylation
R9539 T11873 T11871 themeOf phosphorylation,inhibits
R9540 T11875 T11874 themeOf nleH1,lacking
R9541 T11879 T11880 causeOf TNF,increase
R9542 T11882 T11883 themeOf S209,phosphorylation
R9543 T11882 T11881 partOf S209,RPS3
R9544 T11883 T11880 themeOf phosphorylation,increase
R9545 T11885 T11886 themeOf S209,phosphorylation
R9546 T11885 T11884 partOf S209,RPS3
R9547 T11886 T11887 themeOf phosphorylation,impaired
R9548 T11888 T11889 causeOf TNF,induced
R9549 T11889 T11893 themeOf induced,unimpaired
R9550 T11889 T11894 themeOf induced,unimpaired
R9551 T11891 T11892 themeOf S209,phosphorylation
R9552 T11891 T11890 partOf S209,RPS3
R9553 T11892 T11889 themeOf phosphorylation,induced
R9554 T11895 T11893 causeOf ΔnleH1,unimpaired
R9555 T11896 T11894 causeOf ΔescN,unimpaired
R9556 T11897 T11899 causeOf ΔnleH1,attenuated
R9557 T11898 T11900 causeOf ΔescN,attenuated
R9558 T11901 T11902 causeOf TNF,induced
R9559 T11902 T11899 themeOf induced,attenuated
R9560 T11902 T11900 themeOf induced,attenuated
R9561 T11903 T11905 themeOf RPS3,translocation
R9562 T11904 T11905 locationOf nuclear,translocation
R9563 T11905 T11902 themeOf translocation,induced
R9564 T11906 T11907 themeOf RPS3,phosphorylation
R9565 T11906 T11909 themeOf RPS3,translocation
R9566 T11908 T11909 locationOf nuclear,translocation
R9567 T11910 T11915 themeOf RPS3,translocation
R9568 T11911 T11912 themeOf S209,phosphorylation
R9569 T11911 T11910 partOf S209,RPS3
R9570 T11912 T11913 causeOf phosphorylation,important
R9571 T11914 T11915 locationOf nuclear,translocation
R9572 T11915 T11913 themeOf translocation,important
R9573 T11916 T11917 causeOf NleH1,inhibits
R9574 T11919 T11920 themeOf S209,phosphorylation
R9575 T11919 T11918 partOf S209,RPS3
R9576 T11920 T11917 themeOf phosphorylation,inhibits
R9577 T11928 T11927 themeOf nleH1,deleting
R9578 T11931 T11932 causeOf NleH1,blocking
R9579 T11934 T11935 themeOf S209,phosphorylation
R9580 T11934 T11933 partOf S209,RPS3
R9581 T11935 T11932 themeOf phosphorylation,blocking
R9508 T11837 T11839 themeOf RPS3,translocation
R9510 T11838 T11839 locationOf nuclear,translocation
R9515 T11845 T11842 themeOf phosphorylation,inhibiting

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T11724 0-5 Protein denotes NleH1
T11725 6-14 Negative_regulation denotes inhibits
T11726 15-19 Protein denotes RPS3
T11727 20-35 Phosphorylation denotes phosphorylation
T11728 351-356 Protein denotes NleH1
T11729 357-362 Binding denotes binds
T11730 370-380 Negative_regulation denotes attenuates
T11731 381-385 Protein denotes RPS3
T11732 386-393 Entity denotes nuclear
T11733 394-407 Localization denotes translocation
T11734 424-428 Protein denotes RPS3
T11735 488-493 Protein denotes NleH1
T11736 510-520 Negative_regulation denotes inhibiting
T11737 521-525 Protein denotes RPS3
T11738 526-530 Entity denotes S209
T11739 531-546 Phosphorylation denotes phosphorylation
T11740 596-604 Protein denotes NleH1-HA
T11741 621-625 Protein denotes TNFα
T11742 704-709 Protein denotes NleH1
T11743 710-717 Negative_regulation denotes reduced
T11744 723-726 Protein denotes TNF true
T11745 727-734 Positive_regulation denotes induced
T11746 753-757 Protein denotes RPS3
T11747 758-773 Phosphorylation denotes phosphorylation
T11748 819-829 Gene_expression denotes Expressing
T11749 830-835 Protein denotes NleH1
T11750 867-870 Protein denotes TNF
T11751 871-878 Positive_regulation denotes induced
T11752 883-893 Positive_regulation denotes activation
T11753 897-901 Protein denotes IκBα true
T11754 902-913 Protein_catabolism denotes degradation true
T11755 935-939 Negative_regulation denotes lack
T11756 943-948 Protein denotes NleH1
T11757 949-955 Regulation denotes impact
T11758 959-962 Protein denotes p65
T11759 963-970 Entity denotes nuclear
T11760 971-985 Localization denotes translocation9
T11761 1013-1018 Protein denotes NleH1
T11762 1019-1027 Negative_regulation denotes inhibits
T11763 1028-1032 Protein denotes RPS3
T11764 1033-1048 Phosphorylation denotes phosphorylation
T11765 1116-1123 Negative_regulation denotes lacking
T11766 1131-1136 Protein denotes nleH1
T11767 1138-1144 Protein denotes ΔnleH1
T11768 1206-1211 Protein denotes NleH1
T11769 1234-1239 Protein denotes ΔescN
T11770 1263-1266 Protein denotes TNF
T11771 1298-1306 Positive_regulation denotes increase
T11772 1310-1314 Protein denotes RPS3
T11773 1315-1319 Entity denotes S209
T11774 1320-1335 Phosphorylation denotes phosphorylation
T11775 1383-1387 Protein denotes RPS3
T11776 1388-1392 Entity denotes S209
T11777 1393-1408 Phosphorylation denotes phosphorylation
T11778 1427-1435 Negative_regulation denotes impaired
T11779 1505-1508 Protein denotes TNF
T11780 1509-1516 Positive_regulation denotes induced
T11781 1517-1521 Protein denotes RPS3
T11782 1522-1526 Entity denotes S209
T11783 1527-1542 Phosphorylation denotes phosphorylation
T11784 1547-1557 Negative_regulation denotes unimpaired
T11785 1588-1594 Protein denotes ΔnleH1
T11786 1598-1603 Protein denotes ΔescN
T11787 1660-1666 Protein denotes ΔnleH1
T11788 1670-1675 Protein denotes ΔescN
T11789 1706-1716 Negative_regulation denotes attenuated
T11790 1717-1720 Protein denotes TNF
T11791 1721-1728 Positive_regulation denotes induced
T11792 1729-1733 Protein denotes RPS3
T11793 1734-1741 Entity denotes nuclear
T11794 1742-1756 Localization denotes translocation9
T11795 1779-1783 Protein denotes RPS3
T11796 1784-1799 Phosphorylation denotes phosphorylation
T11797 1808-1815 Entity denotes nuclear
T11798 1816-1829 Localization denotes translocation
T11799 1931-1935 Protein denotes RPS3
T11800 1936-1940 Entity denotes S209
T11801 1941-1956 Phosphorylation denotes phosphorylation
T11802 1960-1969 Positive_regulation denotes important
T11803 1974-1981 Entity denotes nuclear
T11804 1982-1995 Localization denotes translocation
T11805 2016-2021 Protein denotes NleH1
T11806 2022-2030 Negative_regulation denotes inhibits
T11807 2031-2035 Protein denotes RPS3
T11808 2036-2040 Entity denotes S209
T11809 2041-2056 Phosphorylation denotes phosphorylation
T11810 2094-2098 Protein denotes RPS3
T11811 2147-2150 Protein denotes IL8
T11812 2152-2158 Protein denotes NFKBIA
T11813 2164-2171 Protein denotes TNFAIP3
T11814 2331-2337 Protein denotes ΔnleH1
T11815 2341-2346 Protein denotes ΔescN
T11816 2379-2387 Negative_regulation denotes deleting
T11817 2388-2393 Protein denotes nleH1
T11818 2401-2407 Regulation denotes impact
T11819 2415-2425 Gene_expression denotes expression
T11820 2463-2467 Protein denotes CD25
T11821 2472-2480 Protein denotes TNFSF13B
T11822 2546-2551 Protein denotes NleH1
T11823 2617-2625 Negative_regulation denotes blocking
T11824 2626-2630 Protein denotes RPS3
T11825 2631-2635 Entity denotes S209
T11826 2636-2651 Phosphorylation denotes phosphorylation
T11827 2683-2687 Protein denotes RPS3
R9428 T11724 T11725 causeOf NleH1,inhibits
R9429 T11726 T11727 themeOf RPS3,phosphorylation
R9430 T11727 T11725 themeOf phosphorylation,inhibits
R9431 T11728 T11729 themeOf NleH1,binds
R9432 T11729 T11730 causeOf binds,attenuates
R9433 T11731 T11733 themeOf RPS3,translocation
R9434 T11732 T11733 locationOf nuclear,translocation
R9435 T11733 T11730 themeOf translocation,attenuates
R9436 T11735 T11736 causeOf NleH1,inhibiting
R9437 T11738 T11737 partOf S209,RPS3
R9438 T11738 T11739 themeOf S209,phosphorylation
R9439 T11739 T11736 themeOf phosphorylation,inhibiting
R9440 T11742 T11743 causeOf NleH1,reduced
R9441 T11744 T11745 causeOf TNF,induced
R9442 T11745 T11743 themeOf induced,reduced
R9443 T11746 T11747 themeOf RPS3,phosphorylation
R9444 T11747 T11745 themeOf phosphorylation,induced
R9445 T11747 T11743 themeOf phosphorylation,reduced
R9446 T11749 T11748 themeOf NleH1,Expressing
R9447 T11750 T11751 causeOf TNF,induced
R9448 T11752 T11751 themeOf activation,induced
R9449 T11753 T11754 themeOf IκBα,degradation
R9450 T11754 T11751 themeOf degradation,induced
R9451 T11756 T11755 themeOf NleH1,lack
R9452 T11758 T11760 themeOf p65,translocation9
R9453 T11759 T11760 locationOf nuclear,translocation9
R9454 T11760 T11757 themeOf translocation9,impact
R9455 T11761 T11762 causeOf NleH1,inhibits
R9456 T11763 T11764 themeOf RPS3,phosphorylation
R9457 T11764 T11762 themeOf phosphorylation,inhibits
R9458 T11766 T11765 themeOf nleH1,lacking
R9459 T11770 T11771 causeOf TNF,increase
R9460 T11773 T11772 partOf S209,RPS3
R9461 T11773 T11774 themeOf S209,phosphorylation
R9462 T11774 T11771 themeOf phosphorylation,increase
R9463 T11776 T11775 partOf S209,RPS3
R9464 T11776 T11777 themeOf S209,phosphorylation
R9465 T11777 T11778 themeOf phosphorylation,impaired
R9466 T11779 T11780 causeOf TNF,induced
R9467 T11780 T11784 themeOf induced,unimpaired
R9468 T11782 T11783 themeOf S209,phosphorylation
R9469 T11782 T11781 partOf S209,RPS3
R9470 T11783 T11784 themeOf phosphorylation,unimpaired
R9471 T11783 T11780 themeOf phosphorylation,induced
R9472 T11785 T11784 causeOf ΔnleH1,unimpaired
R9473 T11786 T11784 causeOf ΔescN,unimpaired
R9474 T11787 T11789 causeOf ΔnleH1,attenuated
R9475 T11788 T11789 causeOf ΔescN,attenuated
R9476 T11790 T11791 causeOf TNF,induced
R9477 T11791 T11789 themeOf induced,attenuated
R9478 T11792 T11794 themeOf RPS3,translocation9
R9479 T11793 T11794 locationOf nuclear,translocation9
R9480 T11794 T11791 themeOf translocation9,induced
R9481 T11795 T11796 themeOf RPS3,phosphorylation
R9482 T11795 T11798 themeOf RPS3,translocation
R9483 T11797 T11798 locationOf nuclear,translocation
R9484 T11799 T11804 themeOf RPS3,translocation
R9485 T11800 T11799 partOf S209,RPS3
R9486 T11800 T11801 themeOf S209,phosphorylation
R9487 T11801 T11802 causeOf phosphorylation,important
R9488 T11803 T11804 locationOf nuclear,translocation
R9489 T11804 T11802 themeOf translocation,important
R9490 T11805 T11806 causeOf NleH1,inhibits
R9491 T11808 T11807 partOf S209,RPS3
R9492 T11808 T11809 themeOf S209,phosphorylation
R9493 T11809 T11806 themeOf phosphorylation,inhibits
R9494 T11811 T11813 themeOf IL8,TNFAIP3
R9495 T11812 T11813 themeOf NFKBIA,TNFAIP3
R9496 T11817 T11816 themeOf nleH1,deleting
R9497 T11817 T11818 causeOf nleH1,impact
R9498 T11819 T11818 themeOf expression,impact
R9499 T11822 T11823 causeOf NleH1,blocking
R9500 T11825 T11824 partOf S209,RPS3
R9502 T11826 T11823 themeOf phosphorylation,blocking
R9501 T11825 T11826 themeOf S209,phosphorylation