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PMC:3062687 / 130-938 JSONTXT

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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T241 78-82 P23396 denotes RPS3
T242 173-177 P23396 denotes RPS3
T243 234-238 O14920 denotes IKKβ
T244 292-296 P23396 denotes RPS3
T245 429-434 P23396 denotes NleH1
T246 458-462 P23396 denotes RPS3
T247 496-500 P23396 denotes RPS3
T248 641-645 O14920 denotes IKKβ
T249 697-701 P23396 denotes RPS3

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T114 0-5 NN denotes NF-κB
T115 6-8 VB denotes is
T116 9-10 DT denotes a
T117 11-16 JJ denotes major
T118 17-21 NN denotes gene
T119 22-31 NN denotes regulator
T120 32-34 IN denotes in
T121 35-41 JJ denotes immune
T122 42-51 NN denotes responses
T123 52-55 CC denotes and
T124 56-65 JJ denotes ribosomal
T125 66-73 NN denotes protein
T126 74-76 NN denotes S3
T127 77-78 -LRB- denotes (
T128 78-82 NN denotes RPS3
T129 82-83 -RRB- denotes )
T130 84-86 VB denotes is
T131 87-89 DT denotes an
T132 90-95 NN denotes NF-κB
T133 96-103 NN denotes subunit
T134 104-108 WDT denotes that
T135 109-116 VB denotes directs
T136 117-125 JJ denotes specific
T137 126-130 NN denotes gene
T138 131-144 NN denotes transcription
T139 146-153 RB denotes However
T140 153-154 -COMMA- denotes ,
T141 155-157 PRP denotes it
T142 158-160 VB denotes is
T143 161-168 JJ denotes unknown
T144 169-172 WRB denotes how
T145 173-177 NN denotes RPS3
T146 178-185 JJ denotes nuclear
T147 186-199 NN denotes translocation
T148 200-202 VB denotes is
T149 203-212 VB denotes regulated
T150 214-218 RB denotes Here
T151 219-221 PRP denotes we
T152 222-228 VB denotes report
T153 229-233 IN denotes that
T154 234-238 NN denotes IKKβ
T155 239-254 NN denotes phosphorylation
T156 255-257 IN denotes of
T157 258-264 NN denotes serine
T158 265-268 CD denotes 209
T159 269-270 -LRB- denotes (
T160 270-274 NN denotes S209
T161 274-275 -RRB- denotes )
T162 276-279 VB denotes was
T163 280-287 JJ denotes crucial
T164 288-291 IN denotes for
T165 292-296 NN denotes RPS3
T166 297-304 JJ denotes nuclear
T167 305-317 NN denotes localization
T168 318-320 IN denotes in
T169 321-329 NN denotes response
T170 330-332 TO denotes to
T171 333-343 VB denotes activating
T172 344-351 NN denotes stimuli
T173 353-361 RB denotes Moreover
T174 361-362 -COMMA- denotes ,
T175 363-366 DT denotes the
T176 367-376 JJ denotes foodborne
T177 377-385 NN denotes pathogen
T178 386-397 FW denotes Escherichia
T179 398-402 FW denotes coli
T180 403-407 NN denotes O157
T181 407-408 -COLON- denotes :
T182 408-410 NN denotes H7
T183 411-420 NN denotes virulence
T184 421-428 NN denotes protein
T185 429-434 NN denotes NleH1
T186 435-447 RB denotes specifically
T187 448-457 VB denotes inhibited
T188 458-462 NN denotes RPS3
T189 463-467 NN denotes S209
T190 468-483 NN denotes phosphorylation
T191 484-487 CC denotes and
T192 488-495 VB denotes blocked
T193 496-500 NN denotes RPS3
T194 501-509 NN denotes function
T195 509-510 -COMMA- denotes ,
T196 511-518 RB denotes thereby
T197 519-528 VB denotes promoting
T198 529-538 JJ denotes bacterial
T199 539-551 NN denotes colonization
T200 552-555 CC denotes and
T201 556-564 NN denotes diarrhea
T202 565-568 CC denotes but
T203 569-579 VB denotes decreasing
T204 580-589 NN denotes mortality
T205 590-592 IN denotes in
T206 593-594 DT denotes a
T207 595-606 JJ denotes gnotobiotic
T208 607-613 NN denotes piglet
T209 614-623 NN denotes infection
T210 624-629 NN denotes model
T211 631-635 RB denotes Thus
T212 635-636 -COMMA- denotes ,
T213 637-640 DT denotes the
T214 641-655 JJ denotes IKKβ-dependent
T215 656-668 NN denotes modification
T216 669-671 IN denotes of
T217 672-673 DT denotes a
T218 674-682 JJ denotes specific
T219 683-688 NN denotes amino
T220 689-693 NN denotes acid
T221 694-696 IN denotes in
T222 697-701 NN denotes RPS3
T223 702-710 VB denotes promotes
T224 711-719 JJ denotes specific
T225 720-725 NN denotes NF-κB
T226 726-735 NN denotes functions
T227 736-740 WDT denotes that
T228 741-749 VB denotes underlie
T229 750-753 DT denotes the
T230 754-763 JJ denotes molecular
T231 764-776 JJ denotes pathogenetic
T232 777-787 NN denotes mechanisms
T233 788-790 IN denotes of
T234 791-793 FW denotes E.
T235 794-798 FW denotes coli
T236 799-803 NN denotes O157
T237 803-804 -COLON- denotes :
T238 804-806 NN denotes H7
R91 T114 T115 arg1Of NF-κB,is
R92 T115 T123 arg1Of is,and
R93 T119 T115 arg2Of regulator,is
R94 T119 T116 arg1Of regulator,a
R95 T119 T117 arg1Of regulator,major
R96 T119 T118 arg1Of regulator,gene
R97 T119 T120 arg1Of regulator,in
R98 T122 T120 arg2Of responses,in
R99 T122 T121 arg1Of responses,immune
R100 T126 T124 arg1Of S3,ribosomal
R101 T126 T125 arg1Of S3,protein
R102 T126 T127 arg1Of S3,(
R103 T126 T130 arg1Of S3,is
R104 T128 T127 arg2Of RPS3,(
R105 T129 T127 arg3Of ),(
R106 T130 T123 arg2Of is,and
R107 T133 T130 arg2Of subunit,is
R108 T133 T131 arg1Of subunit,an
R109 T133 T132 arg1Of subunit,NF-κB
R110 T133 T134 arg1Of subunit,that
R111 T133 T135 arg1Of subunit,directs
R112 T138 T135 arg2Of transcription,directs
R113 T138 T136 arg1Of transcription,specific
R114 T138 T137 arg1Of transcription,gene
R115 T142 T139 arg1Of is,However
R116 T142 T140 arg1Of is,","
R117 T143 T142 arg2Of unknown,is
R118 T144 T141 arg1Of how,it
R119 T144 T142 arg1Of how,is
R120 T144 T143 arg1Of how,unknown
R121 T147 T145 arg1Of translocation,RPS3
R122 T147 T146 arg1Of translocation,nuclear
R123 T147 T148 arg1Of translocation,is
R124 T147 T149 arg2Of translocation,regulated
R125 T149 T144 arg1Of regulated,how
R126 T149 T148 arg2Of regulated,is
R127 T151 T152 arg1Of we,report
R128 T152 T150 arg1Of report,Here
R129 T155 T154 arg1Of phosphorylation,IKKβ
R130 T155 T156 arg1Of phosphorylation,of
R131 T155 T162 arg1Of phosphorylation,was
R132 T155 T163 arg1Of phosphorylation,crucial
R133 T157 T156 arg2Of serine,of
R134 T157 T158 arg1Of serine,209
R135 T157 T159 arg1Of serine,(
R136 T160 T159 arg2Of S209,(
R137 T161 T159 arg3Of ),(
R138 T162 T152 arg2Of was,report
R139 T162 T153 arg1Of was,that
R140 T162 T168 arg1Of was,in
R141 T163 T162 arg2Of crucial,was
R142 T163 T164 arg1Of crucial,for
R143 T167 T164 arg2Of localization,for
R144 T167 T165 arg1Of localization,RPS3
R145 T167 T166 arg1Of localization,nuclear
R146 T168 T170 arg1Of in,to
R147 T169 T168 arg2Of response,in
R148 T172 T168 arg3Of stimuli,in
R149 T172 T171 arg1Of stimuli,activating
R150 T180 T176 arg1Of O157,foodborne
R151 T180 T177 arg1Of O157,pathogen
R152 T180 T178 arg1Of O157,Escherichia
R153 T180 T179 arg1Of O157,coli
R154 T180 T181 arg1Of O157,:
R155 T181 T175 arg1Of :,the
R156 T181 T187 arg1Of :,inhibited
R157 T181 T192 arg1Of :,blocked
R158 T181 T197 arg1Of :,promoting
R159 T181 T203 arg1Of :,decreasing
R160 T185 T181 arg2Of NleH1,:
R161 T185 T182 arg1Of NleH1,H7
R162 T185 T183 arg1Of NleH1,virulence
R163 T185 T184 arg1Of NleH1,protein
R164 T187 T191 arg1Of inhibited,and
R165 T190 T187 arg2Of phosphorylation,inhibited
R166 T190 T188 arg1Of phosphorylation,RPS3
R167 T190 T189 arg1Of phosphorylation,S209
R168 T191 T173 arg1Of and,Moreover
R169 T191 T174 arg1Of and,","
R170 T191 T186 arg1Of and,specifically
R171 T191 T195 arg1Of and,","
R172 T191 T197 modOf and,promoting
R173 T191 T203 modOf and,decreasing
R174 T192 T191 arg2Of blocked,and
R175 T194 T192 arg2Of function,blocked
R176 T194 T193 arg1Of function,RPS3
R177 T197 T202 arg1Of promoting,but
R178 T199 T200 arg1Of colonization,and
R179 T200 T197 arg2Of and,promoting
R180 T200 T198 arg1Of and,bacterial
R181 T201 T200 arg2Of diarrhea,and
R182 T202 T196 arg1Of but,thereby
R183 T203 T202 arg2Of decreasing,but
R184 T203 T205 arg1Of decreasing,in
R185 T204 T203 arg2Of mortality,decreasing
R186 T210 T205 arg2Of model,in
R187 T210 T206 arg1Of model,a
R188 T210 T207 arg1Of model,gnotobiotic
R189 T210 T208 arg1Of model,piglet
R190 T210 T209 arg1Of model,infection
R191 T215 T213 arg1Of modification,the
R192 T215 T214 arg1Of modification,IKKβ-dependent
R193 T215 T216 arg1Of modification,of
R194 T215 T223 arg1Of modification,promotes
R195 T220 T216 arg2Of acid,of
R196 T220 T217 arg1Of acid,a
R197 T220 T218 arg1Of acid,specific
R198 T220 T219 arg1Of acid,amino
R199 T220 T221 arg1Of acid,in
R200 T222 T221 arg2Of RPS3,in
R201 T223 T211 arg1Of promotes,Thus
R202 T223 T212 arg1Of promotes,","
R203 T226 T223 arg2Of functions,promotes
R204 T226 T224 arg1Of functions,specific
R205 T226 T225 arg1Of functions,NF-κB
R206 T226 T227 arg1Of functions,that
R207 T226 T228 arg1Of functions,underlie
R208 T232 T228 arg2Of mechanisms,underlie
R209 T232 T229 arg1Of mechanisms,the
R210 T232 T230 arg1Of mechanisms,molecular
R211 T232 T231 arg1Of mechanisms,pathogenetic
R212 T232 T233 arg1Of mechanisms,of
R213 T232 T237 arg1Of mechanisms,:
R214 T236 T233 arg2Of O157,of
R215 T236 T234 arg1Of O157,E.
R216 T236 T235 arg1Of O157,coli
R217 T238 T237 arg2Of H7,:

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T284 104-108 WDT denotes that
T285 109-116 VBZ denotes directs
T286 117-125 JJ denotes specific
T287 126-130 NN denotes gene
T288 131-144 NN denotes transcription
T289 144-145 . denotes .
T290 146-153 RB denotes However
T291 153-154 , denotes ,
T292 155-157 PRP denotes it
T293 158-160 VBZ denotes is
T294 161-168 JJ denotes unknown
T295 169-172 WRB denotes how
T296 173-177 JJ denotes RPS3
T297 178-185 JJ denotes nuclear
T298 186-199 NN denotes translocation
T299 200-202 VBZ denotes is
T300 203-212 VBN denotes regulated
T301 212-213 . denotes .
T302 214-218 RB denotes Here
T303 219-221 PRP denotes we
T304 222-228 VBP denotes report
T305 229-233 IN denotes that
T306 234-238 NNP denotes IKKβ
T307 239-254 NN denotes phosphorylation
T308 255-257 IN denotes of
T309 258-264 NN denotes serine
T310 265-268 CD denotes 209
T311 269-270 -LRB- denotes (
T312 270-274 CD denotes S209
T313 274-275 -RRB- denotes )
T314 276-279 VBD denotes was
T315 280-287 JJ denotes crucial
T316 288-291 IN denotes for
T317 292-296 JJ denotes RPS3
T318 297-304 JJ denotes nuclear
T319 305-317 NN denotes localization
T320 318-320 IN denotes in
T321 321-329 NN denotes response
T322 330-332 TO denotes to
T323 333-343 VBG denotes activating
T324 344-351 NNS denotes stimuli
T325 351-352 . denotes .
T326 353-361 RB denotes Moreover
T327 361-362 , denotes ,
T328 363-366 DT denotes the
T329 367-376 NN denotes foodborne
T330 377-385 NN denotes pathogen
T331 386-397 NNP denotes Escherichia
T332 398-402 NNS denotes coli
T333 403-407 NNP denotes O157
T334 407-408 : denotes :
T335 408-410 NNP denotes H7
T336 411-420 NN denotes virulence
T337 421-428 NN denotes protein
T338 429-434 NNP denotes NleH1
T339 435-447 RB denotes specifically
T340 448-457 VBD denotes inhibited
T341 458-462 NNP denotes RPS3
T342 463-467 NNP denotes S209
T343 468-483 NN denotes phosphorylation
T344 484-487 CC denotes and
T345 488-495 VBD denotes blocked
T346 496-500 CD denotes RPS3
T347 501-509 NN denotes function
T348 509-510 , denotes ,
T349 511-518 RB denotes thereby
T350 519-528 VBG denotes promoting
T351 529-538 JJ denotes bacterial
T352 539-551 NN denotes colonization
T353 552-555 CC denotes and
T354 556-564 NN denotes diarrhea
T355 565-568 CC denotes but
T356 569-579 VBG denotes decreasing
T357 580-589 NN denotes mortality
T358 590-592 IN denotes in
T359 593-594 DT denotes a
T360 595-606 JJ denotes gnotobiotic
T361 607-613 NN denotes piglet
T362 614-623 NN denotes infection
T363 624-629 NN denotes model
T364 629-630 . denotes .
T365 631-635 RB denotes Thus
T366 635-636 , denotes ,
T367 637-640 DT denotes the
T368 641-655 JJ denotes IKKβ-dependent
T369 656-668 NN denotes modification
T370 669-671 IN denotes of
T371 672-673 DT denotes a
T372 674-682 JJ denotes specific
T373 683-688 JJ denotes amino
T374 689-693 NN denotes acid
T375 694-696 IN denotes in
T376 697-701 CD denotes RPS3
T377 702-710 VBZ denotes promotes
T378 711-719 JJ denotes specific
T379 720-725 NN denotes NF-κB
T380 726-735 NNS denotes functions
T381 736-740 WDT denotes that
T382 741-749 VBP denotes underlie
T383 750-753 DT denotes the
T384 754-763 JJ denotes molecular
T385 764-776 JJ denotes pathogenetic
T386 777-787 NNS denotes mechanisms
T387 788-790 IN denotes of
T388 791-793 NNP denotes E.
T389 794-798 NNS denotes coli
T390 799-803 NNP denotes O157
T391 803-804 : denotes :
T392 804-806 NNP denotes H7
T393 806-807 . denotes .
T264 0-5 NN denotes NF-κB
T265 6-8 VBZ denotes is
T266 9-10 DT denotes a
T267 11-16 JJ denotes major
T268 17-21 NN denotes gene
T269 22-31 NN denotes regulator
T270 32-34 IN denotes in
T271 35-41 JJ denotes immune
T272 42-51 NNS denotes responses
T273 52-55 CC denotes and
T274 56-65 JJ denotes ribosomal
T275 66-73 NN denotes protein
T276 74-76 NNP denotes S3
T277 77-78 -LRB- denotes (
T278 78-82 NNP denotes RPS3
T279 82-83 -RRB- denotes )
T280 84-86 VBZ denotes is
T281 87-89 DT denotes an
T282 90-95 JJ denotes NF-κB
T283 96-103 NN denotes subunit
R228 T294 T298 amod unknown,translocation
R229 T295 T296 advmod how,RPS3
R230 T296 T298 amod RPS3,translocation
R231 T297 T298 amod nuclear,translocation
R232 T298 T300 nsubjpass translocation,regulated
R233 T299 T300 auxpass is,regulated
R234 T300 T293 ccomp regulated,is
R235 T301 T293 punct .,is
R236 T302 T304 advmod Here,report
R237 T303 T304 nsubj we,report
R238 T304 T304 ROOT report,report
R239 T305 T314 mark that,was
R240 T306 T307 compound IKKβ,phosphorylation
R241 T307 T314 nsubj phosphorylation,was
R242 T308 T307 prep of,phosphorylation
R243 T309 T308 pobj serine,of
R244 T310 T309 nummod 209,serine
R245 T311 T309 punct (,serine
R246 T312 T309 appos S209,serine
R247 T313 T309 punct ),serine
R248 T314 T304 ccomp was,report
R249 T315 T314 acomp crucial,was
R250 T316 T315 prep for,crucial
R251 T317 T319 amod RPS3,localization
R252 T318 T319 amod nuclear,localization
R253 T319 T316 pobj localization,for
R254 T320 T319 prep in,localization
R255 T321 T320 pobj response,in
R256 T322 T321 prep to,response
R257 T323 T322 pcomp activating,to
R258 T324 T323 dobj stimuli,activating
R259 T325 T304 punct .,report
R260 T326 T340 advmod Moreover,inhibited
R261 T327 T340 punct ",",inhibited
R262 T328 T330 det the,pathogen
R263 T329 T330 compound foodborne,pathogen
R264 T330 T340 nsubj pathogen,inhibited
R265 T331 T332 compound Escherichia,coli
R266 T332 T333 compound coli,O157
R267 T333 T330 appos O157,pathogen
R268 T334 T333 punct :,O157
R269 T335 T337 compound H7,protein
R270 T336 T337 compound virulence,protein
R271 T337 T330 conj protein,pathogen
R272 T338 T340 nsubj NleH1,inhibited
R273 T339 T340 advmod specifically,inhibited
R274 T340 T340 ROOT inhibited,inhibited
R275 T341 T343 compound RPS3,phosphorylation
R276 T342 T343 compound S209,phosphorylation
R277 T343 T340 dobj phosphorylation,inhibited
R278 T344 T340 cc and,inhibited
R279 T345 T340 conj blocked,inhibited
R280 T346 T347 nummod RPS3,function
R281 T347 T345 dobj function,blocked
R282 T348 T345 punct ",",blocked
R283 T349 T350 advmod thereby,promoting
R284 T350 T345 advcl promoting,blocked
R285 T351 T352 amod bacterial,colonization
R286 T352 T350 dobj colonization,promoting
R287 T353 T352 cc and,colonization
R288 T354 T352 conj diarrhea,colonization
R289 T355 T350 cc but,promoting
R290 T356 T350 conj decreasing,promoting
R291 T357 T356 dobj mortality,decreasing
R292 T358 T356 prep in,decreasing
R293 T359 T363 det a,model
R294 T360 T363 amod gnotobiotic,model
R295 T361 T363 compound piglet,model
R296 T362 T363 compound infection,model
R297 T363 T358 pobj model,in
R298 T364 T340 punct .,inhibited
R299 T365 T377 advmod Thus,promotes
R300 T366 T377 punct ",",promotes
R301 T367 T369 det the,modification
R302 T368 T369 amod IKKβ-dependent,modification
R303 T369 T377 nsubj modification,promotes
R304 T370 T369 prep of,modification
R305 T371 T374 det a,acid
R306 T372 T374 amod specific,acid
R307 T373 T374 compound amino,acid
R308 T374 T370 pobj acid,of
R309 T375 T369 prep in,modification
R310 T376 T375 pobj RPS3,in
R311 T377 T377 ROOT promotes,promotes
R312 T378 T380 amod specific,functions
R313 T379 T380 amod NF-κB,functions
R314 T380 T377 dobj functions,promotes
R315 T381 T382 nsubj that,underlie
R316 T382 T380 relcl underlie,functions
R317 T383 T386 det the,mechanisms
R318 T384 T386 amod molecular,mechanisms
R319 T385 T386 amod pathogenetic,mechanisms
R320 T386 T382 dobj mechanisms,underlie
R321 T387 T386 prep of,mechanisms
R322 T388 T390 compound E.,O157
R323 T389 T390 compound coli,O157
R324 T390 T387 pobj O157,of
R325 T391 T390 punct :,O157
R326 T392 T390 appos H7,O157
R327 T393 T377 punct .,promotes
R507 T264 T265 nsubj NF-κB,is
R508 T265 T265 ROOT is,is
R509 T266 T269 det a,regulator
R510 T267 T269 amod major,regulator
R511 T268 T269 compound gene,regulator
R512 T269 T265 attr regulator,is
R513 T270 T269 prep in,regulator
R514 T271 T272 amod immune,responses
R515 T272 T270 pobj responses,in
R516 T273 T272 cc and,responses
R517 T274 T276 amod ribosomal,S3
R518 T275 T276 compound protein,S3
R519 T276 T269 appos S3,regulator
R520 T277 T278 punct (,RPS3
R521 T278 T276 appos RPS3,S3
R522 T279 T276 punct ),S3
R523 T280 T265 conj is,is
R524 T281 T283 det an,subunit
R525 T282 T283 amod NF-κB,subunit
R526 T283 T280 attr subunit,is
R223 T289 T265 punct .,is
R224 T290 T293 advmod However,is
R225 T291 T293 punct ",",is
R226 T292 T293 nsubj it,is
R227 T293 T293 ROOT is,is
R218 T284 T285 nsubj that,directs
R219 T285 T283 relcl directs,subunit
R220 T286 T288 amod specific,transcription
R221 T287 T288 compound gene,transcription
R222 T288 T285 dobj transcription,directs

GO-BP

Id Subject Object Predicate Lexical cue
T433 239-254 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T434 468-483 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T435 35-51 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T436 131-144 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T437 305-317 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T438 411-420 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T439 411-420 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence

GO-MF

Id Subject Object Predicate Lexical cue
T440 56-73 http://purl.obolibrary.org/obo/GO_0003735 denotes ribosomal protein

sentences

Id Subject Object Predicate Lexical cue
T95 0-145 Sentence denotes NF-κB is a major gene regulator in immune responses and ribosomal protein S3 (RPS3) is an NF-κB subunit that directs specific gene transcription.
T96 146-213 Sentence denotes However, it is unknown how RPS3 nuclear translocation is regulated.
T97 214-352 Sentence denotes Here we report that IKKβ phosphorylation of serine 209 (S209) was crucial for RPS3 nuclear localization in response to activating stimuli.
T98 353-630 Sentence denotes Moreover, the foodborne pathogen Escherichia coli O157:H7 virulence protein NleH1 specifically inhibited RPS3 S209 phosphorylation and blocked RPS3 function, thereby promoting bacterial colonization and diarrhea but decreasing mortality in a gnotobiotic piglet infection model.
T99 631-807 Sentence denotes Thus, the IKKβ-dependent modification of a specific amino acid in RPS3 promotes specific NF-κB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.
T3 0-145 Sentence denotes NF-κB is a major gene regulator in immune responses and ribosomal protein S3 (RPS3) is an NF-κB subunit that directs specific gene transcription.
T4 146-213 Sentence denotes However, it is unknown how RPS3 nuclear translocation is regulated.
T5 214-352 Sentence denotes Here we report that IKKβ phosphorylation of serine 209 (S209) was crucial for RPS3 nuclear localization in response to activating stimuli.
T6 353-630 Sentence denotes Moreover, the foodborne pathogen Escherichia coli O157:H7 virulence protein NleH1 specifically inhibited RPS3 S209 phosphorylation and blocked RPS3 function, thereby promoting bacterial colonization and diarrhea but decreasing mortality in a gnotobiotic piglet infection model.
T7 631-807 Sentence denotes Thus, the IKKβ-dependent modification of a specific amino acid in RPS3 promotes specific NF-κB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T568 56-76 Protein denotes ribosomal protein S3
T569 78-82 Protein denotes RPS3
T570 173-177 Protein denotes RPS3
T571 178-185 Entity denotes nuclear
T572 186-199 Localization denotes translocation
T573 203-212 Regulation denotes regulated true
T574 234-238 Protein denotes IKKβ
T575 239-254 Phosphorylation denotes phosphorylation
T576 258-268 Entity denotes serine 209
T577 280-287 Positive_regulation denotes crucial
T578 292-296 Protein denotes RPS3
T579 297-304 Entity denotes nuclear
T580 305-317 Localization denotes localization
T581 318-332 Positive_regulation denotes in response to
T582 333-343 Positive_regulation denotes activating
T583 429-434 Protein denotes NleH1
T584 448-457 Negative_regulation denotes inhibited
T585 458-462 Protein denotes RPS3
T586 463-467 Entity denotes S209
T587 468-483 Phosphorylation denotes phosphorylation
T588 488-495 Negative_regulation denotes blocked
T589 496-500 Protein denotes RPS3
T590 641-645 Protein denotes IKKβ
T591 646-655 Regulation denotes dependent
T592 656-668 Protein_modification denotes modification
T593 697-701 Protein denotes RPS3
R444 T569 T568 equivalentTo RPS3,ribosomal protein S3
R445 T570 T572 themeOf RPS3,translocation
R446 T571 T572 locationOf nuclear,translocation
R447 T572 T573 themeOf translocation,regulated
R448 T575 T577 causeOf phosphorylation,crucial
R449 T576 T575 themeOf serine 209,phosphorylation
R450 T576 T574 partOf serine 209,IKKβ
R451 T578 T580 themeOf RPS3,localization
R452 T578 T582 themeOf RPS3,activating
R453 T579 T580 locationOf nuclear,localization
R454 T580 T581 themeOf localization,in response to
R455 T581 T577 themeOf in response to,crucial
R456 T582 T581 causeOf activating,in response to
R457 T583 T584 causeOf NleH1,inhibited
R458 T584 T588 causeOf inhibited,blocked
R459 T586 T587 themeOf S209,phosphorylation
R460 T586 T585 partOf S209,RPS3
R461 T587 T584 themeOf phosphorylation,inhibited
R462 T589 T588 themeOf RPS3,blocked
R463 T590 T591 causeOf IKKβ,dependent
R464 T592 T591 themeOf modification,dependent
R465 T593 T592 themeOf RPS3,modification

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T506 0-5 Protein denotes NF-κB
T507 56-76 Protein denotes ribosomal protein S3
T508 78-82 Protein denotes RPS3
T509 90-95 Protein denotes NF-κB
T510 173-177 Protein denotes RPS3
T511 178-185 Entity denotes nuclear
T512 186-199 Localization denotes translocation
T513 203-212 Regulation denotes regulated
T514 234-238 Protein denotes IKKβ
T515 292-296 Protein denotes RPS3
T516 239-254 Phosphorylation denotes phosphorylation
T517 297-304 Entity denotes nuclear
T518 305-317 Localization denotes localization
T519 280-287 Positive_regulation denotes crucial
T520 429-434 Protein denotes NleH1
T521 458-467 Protein denotes RPS3 S209
T522 496-500 Protein denotes RPS3
T523 468-483 Phosphorylation denotes phosphorylation
T524 488-495 Negative_regulation denotes blocked
T525 448-457 Negative_regulation denotes inhibited
T526 641-645 Protein denotes IKKβ
T527 697-701 Protein denotes RPS3
T528 720-725 Protein denotes NF-κB
T529 702-710 Positive_regulation denotes promotes
R400 T510 T512 themeOf RPS3,translocation
R401 T511 T512 locationOf nuclear,translocation
R402 T512 T513 themeOf translocation,regulated
R403 T514 T516 themeOf IKKβ,phosphorylation
R404 T515 T518 themeOf RPS3,localization
R405 T516 T519 causeOf phosphorylation,crucial
R406 T517 T518 locationOf nuclear,localization
R407 T518 T519 themeOf localization,crucial
R408 T521 T523 themeOf RPS3 S209,phosphorylation
R409 T522 T524 themeOf RPS3,blocked
R410 T523 T525 themeOf phosphorylation,inhibited
R411 T528 T529 themeOf NF-κB,promotes

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T68 56-76 Protein denotes ribosomal protein S3
T69 78-82 Protein denotes RPS3
T70 173-177 Protein denotes RPS3
T71 178-185 Entity denotes nuclear
T72 186-199 Localization denotes translocation
T73 203-212 Regulation denotes regulated true
T74 234-238 Protein denotes IKKβ
T75 239-254 Phosphorylation denotes phosphorylation
T76 258-268 Entity denotes serine 209
T77 280-287 Positive_regulation denotes crucial
T78 292-296 Protein denotes RPS3
T79 297-304 Entity denotes nuclear
T80 305-317 Localization denotes localization
T81 318-332 Positive_regulation denotes in response to
T82 333-343 Positive_regulation denotes activating
T83 429-434 Protein denotes NleH1
T84 448-457 Negative_regulation denotes inhibited
T85 458-462 Protein denotes RPS3
T86 463-467 Entity denotes S209
T87 468-483 Phosphorylation denotes phosphorylation
T88 488-495 Negative_regulation denotes blocked
T89 496-500 Protein denotes RPS3
T90 641-645 Protein denotes IKKβ
T91 646-655 Regulation denotes dependent
T92 656-668 Protein_modification denotes modification
T93 697-701 Protein denotes RPS3
R56 T69 T68 equivalentTo RPS3,ribosomal protein S3
R57 T70 T72 themeOf RPS3,translocation
R58 T71 T72 locationOf nuclear,translocation
R59 T72 T73 themeOf translocation,regulated
R60 T75 T77 causeOf phosphorylation,crucial
R61 T76 T75 themeOf serine 209,phosphorylation
R62 T76 T74 partOf serine 209,IKKβ
R63 T78 T80 themeOf RPS3,localization
R64 T78 T82 themeOf RPS3,activating
R65 T79 T80 locationOf nuclear,localization
R66 T80 T81 themeOf localization,in response to
R67 T81 T77 themeOf in response to,crucial
R68 T82 T81 causeOf activating,in response to
R69 T83 T84 causeOf NleH1,inhibited
R70 T84 T88 causeOf inhibited,blocked
R71 T86 T87 themeOf S209,phosphorylation
R72 T86 T85 partOf S209,RPS3
R73 T87 T84 themeOf phosphorylation,inhibited
R74 T89 T88 themeOf RPS3,blocked
R75 T90 T91 causeOf IKKβ,dependent
R76 T92 T91 themeOf modification,dependent
R77 T93 T92 themeOf RPS3,modification

test2

Id Subject Object Predicate Lexical cue
T39 56-76 Protein denotes ribosomal protein S3
T40 78-82 Protein denotes RPS3
T41 173-177 Protein denotes RPS3
T42 178-185 Entity denotes nuclear
T43 186-199 Localization denotes translocation
T44 203-212 Regulation denotes regulated
T45 234-238 Protein denotes IKKβ
T46 239-254 Phosphorylation denotes phosphorylation
T47 258-268 Entity denotes serine 209
T48 280-287 Positive_regulation denotes crucial
T49 292-296 Protein denotes RPS3
T50 297-304 Entity denotes nuclear
T51 305-317 Localization denotes localization
T52 318-332 Positive_regulation denotes in response to
T53 429-434 Protein denotes NleH1
T54 448-457 Negative_regulation denotes inhibited
T55 458-462 Protein denotes RPS3
T56 463-467 Entity denotes S209
T57 468-483 Phosphorylation denotes phosphorylation
T58 488-495 Negative_regulation denotes blocked
T59 496-500 Protein denotes RPS3
T60 641-645 Protein denotes IKKβ
T61 697-701 Protein denotes RPS3
R33 T40 T39 equivalentTo RPS3,ribosomal protein S3
R34 T41 T43 themeOf RPS3,translocation
R35 T42 T43 locationOf nuclear,translocation
R36 T43 T44 themeOf translocation,regulated
R37 T46 T48 causeOf phosphorylation,crucial
R38 T47 T46 themeOf serine 209,phosphorylation
R39 T47 T45 partOf serine 209,IKKβ
R40 T49 T51 themeOf RPS3,localization
R41 T50 T51 locationOf nuclear,localization
R42 T51 T52 themeOf localization,in response to
R43 T51 T48 themeOf localization,crucial
R44 T52 T48 themeOf in response to,crucial
R45 T53 T54 causeOf NleH1,inhibited
R46 T54 T58 causeOf inhibited,blocked
R47 T56 T55 partOf S209,RPS3
R48 T56 T57 themeOf S209,phosphorylation
R49 T57 T54 themeOf phosphorylation,inhibited
R50 T59 T58 themeOf RPS3,blocked