> top > docs > PMC:3062687 > annotations

PMC:3062687 JSONTXT

Annnotations TAB JSON ListView MergeView

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T239 0-4 O14920 denotes IKKβ
T240 31-35 P23396 denotes RPS3
T241 208-212 P23396 denotes RPS3
T242 303-307 P23396 denotes RPS3
T243 364-368 O14920 denotes IKKβ
T244 422-426 P23396 denotes RPS3
T245 559-564 P23396 denotes NleH1
T246 588-592 P23396 denotes RPS3
T247 626-630 P23396 denotes RPS3
T248 771-775 O14920 denotes IKKβ
T249 827-831 P23396 denotes RPS3
T1132 1179-1182 Q04864 denotes Rel
T1133 1203-1207 Q04206 denotes RelA
T1134 1203-1207 Q04206-3 denotes RelA
T1135 1209-1212 Q04206 denotes p65
T1136 1209-1212 P21579 denotes p65
T1137 1215-1219 Q01201 denotes RelB
T1138 1221-1226 Q04864 denotes c-Rel
T1139 1223-1226 Q04864 denotes Rel
T1140 1228-1231 P19838 denotes p50
T1141 1237-1240 Q00653 denotes p52
T1142 1316-1320 P23396 denotes RPS3
T1143 1335-1338 Q04864 denotes Rel
T1144 1383-1387 P23396 denotes RPS3
T1145 1564-1568 P23396 denotes RPS3
T1146 1908-1913 P23396 denotes NleH1
T1147 1980-1984 P23396 denotes RPS3
T1148 2026-2029 P21579 denotes p65
T1149 2026-2029 Q04206 denotes p65
T1150 2103-2107 P23396 denotes RPS3
T1151 2266-2270 P23396 denotes RPS3
T1152 2353-2357 P23396 denotes RPS3
T1153 2487-2491 P23396 denotes RPS3
T1154 2611-2616 P26358 denotes aimed
T1155 2672-2676 P23396 denotes RPS3
T1156 2762-2766 O14920 denotes IKKβ
T1157 2783-2787 P23396 denotes RPS3
T1158 2810-2814 P23396 denotes RPS3
T1159 2888-2892 P23396 denotes RPS3
T1160 3018-3022 P23396 denotes RPS3
T2157 3126-3130 P23396 denotes RPS3
T2158 3195-3199 P23396 denotes RPS3
T2159 3284-3305 P01375 denotes tumor necrosis factor
T2160 3307-3310 P01375 denotes TNF
T2161 3345-3349 P23396 denotes RPS3
T2162 3458-3461 P01375 denotes TNF
T2163 3497-3501 P23396 denotes RPS3
T2164 3540-3544 P23396 denotes RPS3
T2165 3597-3601 P23396 denotes RPS3
T2166 3718-3721 P01375 denotes TNF
T2167 3821-3825 P25963 denotes IκBα
T2168 3864-3868 P23396 denotes RPS3
T2169 4027-4031 P23396 denotes RPS3
T2807 4044-4048 P23396 denotes RPS3
T2808 4053-4057 O14920 denotes IKKβ
T2809 4199-4203 O14920 denotes IKKβ
T2810 4322-4326 P23396 denotes RPS3
T2811 4359-4362 P21579 denotes p65
T2812 4359-4362 Q04206 denotes p65
T2813 4363-4366 P19838 denotes p50
T2814 4367-4371 P25963 denotes IκBα
T2815 4441-4445 O14920 denotes IKKβ
T2816 4483-4487 P23396 denotes RPS3
T2817 4532-4536 O14920 denotes IKKβ
T2818 4541-4545 P23396 denotes RPS3
T2819 4639-4643 O14920 denotes IKKβ
T2820 4644-4648 P23396 denotes RPS3
T2821 4775-4779 P23396 denotes RPS3
T2822 4780-4784 O14920 denotes IKKβ
T2823 4824-4827 P01375 denotes TNF
T2824 4901-4905 P23396 denotes RPS3
T2825 4997-5001 P23396 denotes RPS3
T3830 5023-5027 O14920 denotes IKKβ
T3831 5044-5048 P23396 denotes RPS3
T3832 5094-5098 P23396 denotes RPS3
T3833 5099-5103 O14920 denotes IKKβ
T3834 5132-5136 P23396 denotes RPS3
T3835 5184-5188 O14920 denotes IKKβ
T3836 5273-5277 P23396 denotes RPS3
T3837 5325-5328 P01375 denotes TNF
T3838 5349-5353 P23396 denotes RPS3
T3839 5456-5460 P23396 denotes RPS3
T3840 5566-5570 O14920 denotes IKKβ
T3841 5592-5596 P23396 denotes RPS3
T3842 5721-5725 O14920 denotes IKKβ
T3843 5778-5782 P23396 denotes RPS3
T3844 5850-5853 Q04206 denotes p65
T3845 5850-5853 P21579 denotes p65
T3846 5971-5975 P23396 denotes RPS3
T3847 6073-6077 O14920 denotes IKKβ
T3848 6135-6139 O14920 denotes IKKβ
T3849 6164-6174 P08659 denotes luciferase
T3850 6218-6222 P23396 denotes RPS3
T3851 6245-6249 O14920 denotes IKKβ
T3852 6320-6324 P23396 denotes RPS3
T3853 6373-6377 O14920 denotes IKKβ
T3854 6457-6461 P23396 denotes RPS3
T3855 6482-6486 O14920 denotes IKKβ
T3856 6523-6527 O14920 denotes IKKβ
T3857 6593-6597 O14920 denotes IKKβ
T3858 6639-6643 P23396 denotes RPS3
T5567 6708-6712 P25963 denotes IκBα
T5568 6729-6733 P23396 denotes RPS3
T5569 6805-6808 Q04864 denotes Rel
T5570 6825-6829 P23396 denotes RPS3
T5571 6958-6961 P21579 denotes p65
T5572 6958-6961 Q04206 denotes p65
T5573 6997-7001 P23396 denotes RPS3
T5574 7076-7080 P23396 denotes RPS3
T5575 7146-7149 P01375 denotes TNF
T5576 7209-7213 P23396 denotes RPS3
T5577 7306-7310 P25963 denotes IκBα
T5578 7362-7365 Q04206 denotes p65
T5579 7362-7365 P21579 denotes p65
T5580 7376-7380 P23396 denotes RPS3
T5581 7385-7389 P25963 denotes IκBα
T5582 7398-7401 Q04206 denotes p65
T5583 7398-7401 P21579 denotes p65
T5584 7459-7463 P25963 denotes IκBα
T5585 7510-7514 P23396 denotes RPS3
T5586 7547-7551 P23396 denotes RPS3
T5587 7607-7611 P25963 denotes IκBα
T5588 7618-7622 P25963 denotes IκBα
T5589 7650-7654 O14920 denotes IKKβ
T5590 7732-7736 P25963 denotes IκBα
T5591 7738-7741 P01375 denotes TNF
T5592 7783-7787 P23396 denotes RPS3
T5593 7886-7890 P23396 denotes RPS3
T5594 7962-7966 P25963 denotes IκBα
T5595 7997-8001 P25963 denotes IκBα
T5596 8045-8049 P23396 denotes RPS3
T5597 8090-8094 P23396 denotes RPS3
T5598 8130-8134 P23396 denotes RPS3
T5599 8150-8154 P25963 denotes IκBα
T5600 8219-8223 P25963 denotes IκBα
T5601 8244-8248 P25963 denotes IκBα
T5602 8301-8305 P23396 denotes RPS3
T5603 8386-8390 P23396 denotes RPS3
T5604 8474-8478 P25963 denotes IκBα
T5605 8576-8580 P23396 denotes RPS3
T5606 8659-8663 P23396 denotes RPS3
T5607 8682-8686 P25963 denotes IκBα
T5608 8864-8868 P23396 denotes RPS3
T5609 8875-8879 P25963 denotes IκBα
T5610 8907-8910 P01375 denotes TNF
T5611 8967-8971 P23396 denotes RPS3
T5612 9010-9013 P01375 denotes TNF
T5613 9049-9053 P25963 denotes IκBα
T5614 9133-9137 P23396 denotes RPS3
T5615 9243-9247 O14920 denotes IKKβ
T5616 9267-9271 P23396 denotes RPS3
T7633 9287-9291 O14920 denotes IKKβ
T7634 9307-9311 P23396 denotes RPS3
T7635 9395-9399 O14920 denotes IKKβ
T7636 9463-9468 O95999 denotes Bcl10
T7637 9552-9556 O14920 denotes IKKβ
T7638 9586-9590 P23396 denotes RPS3
T7639 9644-9648 P23396 denotes RPS3
T7640 9729-9733 O14920 denotes IKKβ
T7641 9784-9788 P25963 denotes IκBα
T7642 9896-9900 O14920 denotes IKKβ
T7643 9934-9938 P23396 denotes RPS3
T7644 9966-9970 O14920 denotes IKKβ
T7645 10045-10049 P23396 denotes RPS3
T7646 10090-10094 O14920 denotes IKKβ
T7647 10195-10199 P23396 denotes RPS3
T7648 10228-10232 O14920 denotes IKKβ
T7649 10269-10273 P23396 denotes RPS3
T7650 10296-10300 P23396 denotes RPS3
T7651 10599-10603 O14920 denotes IKKβ
T7652 10707-10711 P23396 denotes RPS3
T7653 10786-10790 O14920 denotes IKKβ
T7654 10800-10804 P23396 denotes RPS3
T7655 10943-10947 P23396 denotes RPS3
T7656 10959-10963 P23396 denotes RPS3
T7657 11140-11144 O14920 denotes IKKβ
T7658 11298-11302 P23396 denotes RPS3
T7659 11368-11372 O14920 denotes IKKβ
T7660 11487-11491 O14920 denotes IKKβ
T7661 11507-11511 P23396 denotes RPS3
T7662 11579-11583 P23396 denotes RPS3
T7663 11608-11612 O14920 denotes IKKβ
T7664 11665-11669 O14920 denotes IKKβ
T7665 11684-11688 P23396 denotes RPS3
T7666 11833-11837 O14920 denotes IKKβ
T7667 11898-11902 P23396 denotes RPS3
T7668 11942-11946 P23396 denotes RPS3
T7669 12006-12009 P01375 denotes TNF
T7670 12043-12047 P23396 denotes RPS3
T9793 12135-12139 P23396 denotes RPS3
T9794 12254-12258 P23396 denotes RPS3
T9795 12344-12348 P23396 denotes RPS3
T9796 12608-12612 P23396 denotes RPS3
T9797 12655-12659 P23396 denotes RPS3
T9798 12780-12784 O14920 denotes IKKβ
T9799 12788-12792 P23396 denotes RPS3
T9800 12816-12820 O14920 denotes IKKβ
T9801 12864-12874 P08659 denotes luciferase
T9802 12978-12982 P23396 denotes RPS3
T9803 13084-13088 P23396 denotes RPS3
T9804 13159-13163 P23396 denotes RPS3
T9805 13218-13222 P23396 denotes RPS3
T9806 13301-13305 P23396 denotes RPS3
T9807 13378-13382 P23396 denotes RPS3
T9808 13414-13418 P23396 denotes RPS3
T9809 13453-13457 P23396 denotes RPS3
T9810 13546-13550 P23396 denotes RPS3
T9811 13629-13633 P23396 denotes RPS3
T9812 13652-13655 P01375 denotes TNF
T9813 13694-13704 P08659 denotes luciferase
T9814 13740-13750 P08659 denotes luciferase
T9815 13768-13772 P23396 denotes RPS3
T9816 13852-13856 P23396 denotes RPS3
T9817 13940-13944 P23396 denotes RPS3
T9818 13956-13966 P08659 denotes luciferase
T9819 14085-14088 Q9U6Y4 denotes GFP
T9820 14151-14155 P23396 denotes RPS3
T9821 14220-14224 P23396 denotes RPS3
T9822 14406-14410 P23396 denotes RPS3
T9823 14415-14418 Q04206 denotes p65
T9824 14415-14418 P21579 denotes p65
T9825 14500-14504 P23396 denotes RPS3
T9826 14618-14622 P23396 denotes RPS3
T9827 14646-14652 P25963 denotes NFKBIA
T9828 14657-14660 P10145 denotes IL8
T9829 14699-14703 P23396 denotes RPS3
T9830 14727-14730 P21579 denotes p65
T9831 14727-14730 Q04206 denotes p65
T9832 14782-14785 P21579 denotes p65
T9833 14782-14785 Q04206 denotes p65
T9834 14846-14849 P21579 denotes p65
T9835 14846-14849 Q04206 denotes p65
T9836 14864-14868 P23396 denotes RPS3
T9837 14917-14921 P01589 denotes CD25
T9838 15034-15038 P23396 denotes RPS3
T9839 15042-15045 Q04206 denotes p65
T9840 15042-15045 P21579 denotes p65
T9841 15061-15065 P60709 denotes ACTB
T9842 15177-15181 P23396 denotes RPS3
T9843 15223-15226 Q04206 denotes p65
T9844 15223-15226 P21579 denotes p65
T9845 15262-15275 P10145 denotes Interleukin 8
T9846 15277-15281 P10145 denotes IL-8
T9847 15404-15408 P23396 denotes RPS3
T9848 15409-15412 P21579 denotes p65
T9849 15409-15412 Q04206 denotes p65
T9850 15432-15435 P10145 denotes IL8
T9851 15499-15503 P23396 denotes RPS3
T9852 15551-15555 P01589 denotes CD25
T9853 15614-15618 P23396 denotes RPS3
T9854 15673-15677 P23396 denotes RPS3
T9855 15702-15706 O14920 denotes IKKβ
T9856 15734-15738 P23396 denotes RPS3
T12387 15797-15802 P23396 denotes NleH1
T12388 15812-15816 P23396 denotes RPS3
T12389 16148-16153 P23396 denotes NleH1
T12390 16178-16182 P23396 denotes RPS3
T12391 16221-16225 P23396 denotes RPS3
T12392 16285-16290 P23396 denotes NleH1
T12393 16318-16322 P23396 denotes RPS3
T12394 16393-16398 P23396 denotes NleH1
T12395 16501-16506 P23396 denotes NleH1
T12396 16520-16523 P01375 denotes TNF
T12397 16550-16554 P23396 denotes RPS3
T12398 16627-16632 P23396 denotes NleH1
T12399 16664-16667 P01375 denotes TNF
T12400 16694-16698 P25963 denotes IκBα
T12401 16740-16745 P23396 denotes NleH1
T12402 16756-16759 P21579 denotes p65
T12403 16756-16759 Q04206 denotes p65
T12404 16810-16815 P23396 denotes NleH1
T12405 16825-16829 P23396 denotes RPS3
T12406 16928-16933 P23396 denotes nleH1
T12407 16935-16941 P23396 denotes ΔnleH1
T12408 17003-17008 P23396 denotes NleH1
T12409 17031-17036 Q7DB71 denotes ΔescN
T12410 17060-17063 P01375 denotes TNF
T12411 17107-17111 P23396 denotes RPS3
T12412 17180-17184 P23396 denotes RPS3
T12413 17302-17305 P01375 denotes TNF
T12414 17314-17318 P23396 denotes RPS3
T12415 17385-17391 P23396 denotes ΔnleH1
T12416 17395-17400 Q7DB71 denotes ΔescN
T12417 17457-17463 P23396 denotes ΔnleH1
T12418 17467-17472 Q7DB71 denotes ΔescN
T12419 17514-17517 P01375 denotes TNF
T12420 17526-17530 P23396 denotes RPS3
T12421 17576-17580 P23396 denotes RPS3
T12422 17728-17732 P23396 denotes RPS3
T12423 17813-17818 P23396 denotes NleH1
T12424 17828-17832 P23396 denotes RPS3
T12425 17891-17895 P23396 denotes RPS3
T12426 17944-17947 P10145 denotes IL8
T12427 17949-17955 P25963 denotes NFKBIA
T12428 17961-17968 P21580 denotes TNFAIP3
T12429 18128-18134 P23396 denotes ΔnleH1
T12430 18138-18143 Q7DB71 denotes ΔescN
T12431 18185-18190 P23396 denotes nleH1
T12432 18226-18230 P23396 denotes RPS3
T12433 18260-18264 P01589 denotes CD25
T12434 18343-18348 P23396 denotes NleH1
T12435 18423-18427 P23396 denotes RPS3
T12436 18480-18484 P23396 denotes RPS3
T13936 18516-18521 P23396 denotes NleH1
T13937 18531-18535 P23396 denotes RPS3
T13938 18665-18671 P23396 denotes ΔnleH1
T13939 18771-18777 P23396 denotes ΔnleH1
T13940 19007-19012 P23396 denotes NleH1
T13941 19021-19025 P23396 denotes RPS3
T13942 19075-19079 P23396 denotes RPS3
T13943 19223-19227 P23396 denotes RPS3
T13944 19361-19365 P23396 denotes RPS3
T13945 19409-19415 P23396 denotes ΔnleH1
T13946 19432-19436 P23396 denotes RPS3
T13947 19510-19515 P23396 denotes NleH1
T13948 19525-19529 P23396 denotes RPS3
T15646 19647-19652 P23396 denotes NleH1
T15647 19664-19668 O14920 denotes IKKβ
T15648 19693-19698 P23396 denotes NleH1
T15649 19824-19829 P23396 denotes NleH1
T15650 19839-19843 P23396 denotes RPS3
T15651 19938-19943 P23396 denotes NleH1
T15652 19969-19974 P23396 denotes NleH1
T15653 20008-20013 P23396 denotes NleH1
T15654 20056-20061 P23396 denotes NleH1
T15655 20147-20152 P23396 denotes NleH1
T15656 20164-20168 O14920 denotes IKKβ
T15657 20188-20192 P23396 denotes RPS3
T15658 20254-20259 P23396 denotes NleH1
T15659 20285-20290 P23396 denotes NleH1
T15660 20324-20327 P01375 denotes TNF
T15661 20336-20340 P23396 denotes RPS3
T15662 20420-20425 P23396 denotes NleH1
T15663 20465-20469 P23396 denotes RPS3
T15664 20475-20479 O14920 denotes IKKβ
T15665 20663-20667 P23396 denotes RPS3
T15666 20694-20698 P23396 denotes RPS3
T15667 20715-20725 P08659 denotes luciferase
T15668 20770-20775 P23396 denotes NleH1
T15669 20797-20801 P23396 denotes RPS3
T15670 20904-20907 P01375 denotes TNF
T15671 20953-20957 P23396 denotes RPS3
T15672 21011-21015 P23396 denotes RPS3
T15673 21113-21117 P23396 denotes RPS3
T15674 21262-21267 P23396 denotes NleH1
T15675 21390-21395 P23396 denotes NleH1
T15676 21439-21444 P23396 denotes NleH1
T15677 21462-21465 P01375 denotes TNF
T15678 21474-21478 P23396 denotes RPS3
T15679 21551-21555 P23396 denotes RPS3
T15680 21628-21633 P23396 denotes NleH1
T15681 21671-21675 P23396 denotes RPS3
T15682 21750-21755 P23396 denotes NleH1
T15683 21825-21829 P23396 denotes RPS3
T15684 21867-21871 O14920 denotes IKKβ
T15685 21873-21877 O14920 denotes IKKβ
T15686 21959-21963 O14920 denotes IKKβ
T15687 21989-21993 P23396 denotes RPS3
T15688 22037-22041 O14920 denotes IKKβ
T15689 22068-22072 P23396 denotes RPS3
T15690 22217-22223 P23396 denotes ΔnleH1
T15691 22227-22232 Q7DB71 denotes ΔescN
T15692 22264-22268 P23396 denotes RPS3
T15693 22301-22305 O14920 denotes IKKβ
T15694 22310-22314 O14920 denotes IKKβ
T15695 22401-22405 P23396 denotes RPS3
T15696 22431-22435 O14920 denotes IKKβ
T15697 22525-22530 P23396 denotes NleH1
T15698 22565-22569 P23396 denotes RPS3
T15699 22642-22646 O14920 denotes IKKβ
T15700 22668-22673 P23396 denotes NleH1
T15701 22703-22707 O14920 denotes IKKβ
T15702 22724-22728 O14920 denotes IKKβ
T15703 22738-22742 P23396 denotes RPS3
T15704 22831-22835 O14920 denotes IKKβ
T15705 22876-22881 P23396 denotes NleH1
T15706 22901-22905 O14920 denotes IKKβ
T15707 22944-22949 P23396 denotes NleH1
T15708 23039-23043 O14920 denotes IKKβ
T15709 23138-23143 P23396 denotes NleH1
T15710 23160-23164 O14920 denotes IKKβ
T15711 23277-23281 O14920 denotes IKKβ
T15712 23296-23300 O14920 denotes IKKβ
T15713 23316-23320 P23396 denotes RPS3
T15714 23347-23351 P25963 denotes IκBα
T15715 23469-23473 O14920 denotes IKKβ
T15716 23479-23484 P23396 denotes NleH1
T15717 23493-23497 O14920 denotes IKKβ
T15718 23507-23511 P23396 denotes RPS3
T15719 23570-23574 O14920 denotes IKKβ
T15720 23588-23592 P25963 denotes IκBα
T15721 23685-23690 P23396 denotes NleH1
T15722 23742-23746 P23396 denotes RPS3
T15723 23754-23758 P25963 denotes IκBα
T15724 23786-23791 P23396 denotes NleH1
T15725 23832-23836 O14920 denotes IKKβ
T15726 23857-23861 O14920 denotes IKKβ
T15727 23871-23875 P23396 denotes RPS3
T18781 24005-24009 P23396 denotes RPS3
T18782 24183-24187 P23396 denotes RPS3
T18783 24273-24277 O14920 denotes IKKβ
T18784 24287-24291 P23396 denotes RPS3
T18785 24449-24453 O14920 denotes IKKβ
T18786 24586-24590 P23396 denotes RPS3
T18787 24716-24720 O14920 denotes IKKβ
T18788 24815-24819 O14920 denotes IKKβ
T18789 24850-24854 P23396 denotes RPS3
T18790 24915-24919 P23396 denotes RPS3
T18791 25049-25052 P21579 denotes p65
T18792 25049-25052 Q04206 denotes p65
T18793 25144-25148 O14920 denotes IKKβ
T18794 25190-25194 P23396 denotes RPS3
T18795 25246-25250 O14920 denotes IKKβ
T18796 25308-25312 P23396 denotes RPS3
T18797 25378-25382 P23396 denotes RPS3
T18798 25534-25538 P23396 denotes RPS3
T18799 25687-25691 O14920 denotes IKKβ
T18800 25701-25705 P23396 denotes RPS3
T18801 25831-25836 P23396 denotes NleH1
T18802 25859-25863 P23396 denotes RPS3
T18803 25997-26002 P23396 denotes NleH1
T18804 26024-26028 P23396 denotes RPS3
T18805 26167-26172 P23396 denotes NleH1
T18806 26204-26208 O14920 denotes IKKβ
T18807 26254-26258 O14920 denotes IKKβ
T18808 26268-26272 P23396 denotes RPS3
T18809 26424-26429 P23396 denotes NleH1
T18810 26468-26472 O14920 denotes IKKβ
T18811 26739-26744 P23396 denotes NleH1
T18812 26777-26781 P23396 denotes RPS3
T18813 26911-26914 P10145 denotes IL8
T18814 26919-26922 P01375 denotes TNF
T18815 26937-26942 P23396 denotes NleH1
T18816 26964-26967 P21579 denotes p65
T18817 26964-26967 Q04206 denotes p65
T18818 27019-27022 Q04206 denotes p65
T18819 27019-27022 P21579 denotes p65
T18820 27037-27041 P23396 denotes RPS3
T18821 27186-27190 P23396 denotes RPS3
T18822 27229-27234 P23396 denotes NleH1
T18823 27830-27834 P23396 denotes RPS3
T18824 27853-27856 Q04206 denotes p65
T18825 27853-27856 P21579 denotes p65
T18826 28136-28140 P23396 denotes RPS3
T20205 28402-28406 P25963 denotes IκBα
T20206 28423-28426 P21579 denotes p65
T20207 28423-28426 Q04206 denotes p65
T20208 28527-28534 P60709 denotes β-actin
T20209 28719-28723 O14920 denotes IKKβ
T20210 28873-28877 P25963 denotes IκBα
T20211 29086-29090 P23396 denotes RPS3
T20212 29195-29199 P23396 denotes RPS3
T20625 29326-29330 O14920 denotes IKKβ
T20626 29344-29348 O14920 denotes IKKβ
T20627 29364-29368 P25963 denotes IκBα
T20628 29484-29488 P25963 denotes IκBα
T20629 29493-29497 O14920 denotes IKKβ
T20630 29563-29567 P23396 denotes RPS3
T20631 29573-29577 P23396 denotes RPS3
T20632 29582-29586 P23396 denotes RPS3
T20633 29595-29600 P23396 denotes NleH1
T20634 29665-29669 P23396 denotes RPS3
T20905 30115-30118 P01375 denotes TNF
T20906 30232-30236 P23396 denotes RPS3
T21148 30296-30300 O14920 denotes IKKβ
T21149 30439-30443 P25963 denotes IκBα
T21150 30474-30478 P23396 denotes RPS3
T21151 30483-30487 P23396 denotes RPS3
T21152 30693-30695 P0A7Z4 denotes pH
T21153 30762-30767 P23396 denotes NleH1
T21154 30801-30803 P0A7Z4 denotes pH
T21438 31013-31017 P23396 denotes RPS3
T21439 31049-31053 O14920 denotes IKKβ
T21599 31526-31530 O14920 denotes IKKβ
T21600 31566-31570 P25963 denotes IκBα
T21601 31606-31610 P23396 denotes RPS3
T21862 31963-31965 P0A7Z4 denotes pH
T22106 32510-32520 P08659 denotes Luciferase
T22107 32542-32552 P08659 denotes Luciferase
T22108 32705-32715 P08659 denotes luciferase
T22109 32742-32752 P08659 denotes luciferase
T22110 32922-32932 P08659 denotes Luciferase
T22254 33114-33117 P10145 denotes IL8
T22255 33122-33128 P25963 denotes NFKBIA
T22256 33141-33145 P60709 denotes ACTB
T22422 33474-33478 P23396 denotes RPS3
T22800 33873-33875 P0A7Z4 denotes pH
T23136 35151-35155 P10145 denotes IL-8
T23137 35242-35255 P10145 denotes Interleukin-8
T23282 35706-35710 P23396 denotes RPS3

2_test

Id Subject Object Predicate Lexical cue
21399639-17072322-74765153 4304-4306 17072322 denotes 20
21399639-17072322-74765153 4304-4306 17072322 denotes 20
21399639-10602462-74765153 4304-4306 10602462 denotes 20
21399639-10602462-74765153 4304-4306 10602462 denotes 20
21399639-10740266-74765153 4304-4306 10740266 denotes 20
21399639-10740266-74765153 4304-4306 10740266 denotes 20
21399639-18045535-74765154 4407-4408 18045535 denotes 6
21399639-18045535-74765154 4407-4408 18045535 denotes 6
21399639-18045535-74765155 5453-5454 18045535 denotes 6
21399639-18045535-74765155 5453-5454 18045535 denotes 6
21399639-18462924-74765156 6817-6819 18462924 denotes 23
21399639-18462924-74765156 6817-6819 18462924 denotes 23
21399639-15677444-74765157 6821-6823 15677444 denotes 24
21399639-15677444-74765157 6821-6823 15677444 denotes 24
21399639-18045535-74765158 6975-6976 18045535 denotes 6
21399639-18045535-74765158 6975-6976 18045535 denotes 6
21399639-8797825-74765159 8527-8529 8797825 denotes 25
21399639-8797825-74765159 8527-8529 8797825 denotes 25
21399639-17537731-74765159 8527-8529 17537731 denotes 25
21399639-17537731-74765159 8527-8529 17537731 denotes 25
21399639-12429743-74765159 8527-8529 12429743 denotes 25
21399639-12429743-74765159 8527-8529 12429743 denotes 25
21399639-10837071-74765160 9391-9393 10837071 denotes 19
21399639-10837071-74765160 9391-9393 10837071 denotes 19
21399639-16818229-74765161 9517-9519 16818229 denotes 28
21399639-16818229-74765161 9517-9519 16818229 denotes 28
21399639-18045535-74765162 13185-13186 18045535 denotes 6
21399639-18045535-74765162 13185-13186 18045535 denotes 6
21399639-20066093-74765163 13188-13189 20066093 denotes 7
21399639-20066093-74765163 13188-13189 20066093 denotes 7
21399639-19997086-74765164 13191-13193 19997086 denotes 30
21399639-19997086-74765164 13191-13193 19997086 denotes 30
21399639-18045535-74765165 13714-13715 18045535 denotes 6
21399639-18045535-74765165 13714-13715 18045535 denotes 6
21399639-18045535-74765166 15001-15002 18045535 denotes 6
21399639-18045535-74765166 15001-15002 18045535 denotes 6
21399639-8852900-74765167 15941-15943 8852900 denotes 31
21399639-8852900-74765167 15941-15943 8852900 denotes 31
21399639-20041225-74765168 16094-16095 20041225 denotes 9
21399639-20041225-74765168 16094-16095 20041225 denotes 9
21399639-20126447-74765169 16097-16099 20126447 denotes 33
21399639-20126447-74765169 16097-16099 20126447 denotes 33
21399639-20485572-74765169 16097-16099 20485572 denotes 33
21399639-20485572-74765169 16097-16099 20485572 denotes 33
21399639-21091507-74765169 16097-16099 21091507 denotes 33
21399639-21091507-74765169 16097-16099 21091507 denotes 33
21399639-21113130-74765169 16097-16099 21113130 denotes 33
21399639-21113130-74765169 16097-16099 21113130 denotes 33
21399639-20833837-74765169 16097-16099 20833837 denotes 33
21399639-20833837-74765169 16097-16099 20833837 denotes 33
21399639-21187904-74765169 16097-16099 21187904 denotes 33
21399639-21187904-74765169 16097-16099 21187904 denotes 33
21399639-20041225-74765170 16251-16252 20041225 denotes 9
21399639-20041225-74765170 16251-16252 20041225 denotes 9
21399639-20041225-74765171 16486-16487 20041225 denotes 9
21399639-20041225-74765171 16486-16487 20041225 denotes 9
21399639-20041225-74765172 16781-16782 20041225 denotes 9
21399639-20041225-74765172 16781-16782 20041225 denotes 9
21399639-20041225-74765173 17552-17553 20041225 denotes 9
21399639-20041225-74765173 17552-17553 20041225 denotes 9
21399639-20041225-74765174 18912-18913 20041225 denotes 9
21399639-20041225-74765174 18912-18913 20041225 denotes 9
21399639-20041225-74765175 19787-19788 20041225 denotes 9
21399639-20041225-74765175 19787-19788 20041225 denotes 9
21399639-12657048-74765176 20595-20597 12657048 denotes 39
21399639-12657048-74765176 20595-20597 12657048 denotes 39
21399639-20041225-74765177 20782-20783 20041225 denotes 9
21399639-20041225-74765177 20782-20783 20041225 denotes 9
21399639-18045535-74765178 24112-24113 18045535 denotes 6
21399639-18045535-74765178 24112-24113 18045535 denotes 6
21399639-17047224-74765179 24570-24572 17047224 denotes 40
21399639-17047224-74765179 24570-24572 17047224 denotes 40
21399639-16818647-74765180 25090-25092 16818647 denotes 41
21399639-16818647-74765180 25090-25092 16818647 denotes 41
21399639-10938077-74765180 25090-25092 10938077 denotes 41
21399639-10938077-74765180 25090-25092 10938077 denotes 41
21399639-15033982-74765180 25090-25092 15033982 denotes 41
21399639-15033982-74765180 25090-25092 15033982 denotes 41
21399639-20041225-74765181 25971-25972 20041225 denotes 9
21399639-20041225-74765181 25971-25972 20041225 denotes 9
21399639-18045535-74765182 29128-29129 18045535 denotes 6
21399639-18045535-74765182 29128-29129 18045535 denotes 6
21399639-8622650-74765183 29546-29548 8622650 denotes 44
21399639-8622650-74765183 29546-29548 8622650 denotes 44
21399639-9710600-74765184 29550-29552 9710600 denotes 45
21399639-9710600-74765184 29550-29552 9710600 denotes 45
21399639-18045535-74765185 29638-29639 18045535 denotes 6
21399639-18045535-74765185 29638-29639 18045535 denotes 6
21399639-20041225-74765186 29641-29642 20041225 denotes 9
21399639-20041225-74765186 29641-29642 20041225 denotes 9
21399639-18045535-74765187 31770-31771 18045535 denotes 6
21399639-18045535-74765187 31770-31771 18045535 denotes 6
21399639-18045535-74765188 31894-31895 18045535 denotes 6
21399639-18045535-74765188 31894-31895 18045535 denotes 6
21399639-18045535-74765189 32612-32613 18045535 denotes 6
21399639-18045535-74765189 32612-32613 18045535 denotes 6
21399639-18045535-74765190 33035-33036 18045535 denotes 6
21399639-18045535-74765190 33035-33036 18045535 denotes 6
21399639-18045535-74765191 33165-33166 18045535 denotes 6
21399639-18045535-74765191 33165-33166 18045535 denotes 6
21399639-18045535-74765192 33256-33257 18045535 denotes 6
21399639-18045535-74765192 33256-33257 18045535 denotes 6
21399639-18045535-74765193 34695-34696 18045535 denotes 6
21399639-18045535-74765193 34695-34696 18045535 denotes 6
21399639-20041225-74765194 35449-35450 20041225 denotes 9
21399639-20041225-74765194 35449-35450 20041225 denotes 9
21399639-20041225-74765195 35560-35561 20041225 denotes 9
21399639-20041225-74765195 35560-35561 20041225 denotes 9

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T100 0-4 NN denotes IKKβ
T101 5-20 NN denotes phosphorylation
T102 21-30 VB denotes regulates
T103 31-35 NN denotes RPS3
T104 36-43 JJ denotes nuclear
T105 44-57 NN denotes translocation
T106 58-61 CC denotes and
T107 62-67 NN denotes NF-κB
T108 68-76 NN denotes function
T109 77-95 NN denotes during Escherichia
T110 96-105 NN denotes coli O157
T111 105-106 -COLON- denotes :
T112 106-108 NN denotes H7
T113 109-118 NN denotes infection
T114 130-135 NN denotes NF-κB
T115 136-138 VB denotes is
T116 139-140 DT denotes a
T117 141-146 JJ denotes major
T118 147-151 NN denotes gene
T119 152-161 NN denotes regulator
T120 162-164 IN denotes in
T121 165-171 JJ denotes immune
T122 172-181 NN denotes responses
T123 182-185 CC denotes and
T124 186-195 JJ denotes ribosomal
T125 196-203 NN denotes protein
T126 204-206 NN denotes S3
T127 207-208 -LRB- denotes (
T128 208-212 NN denotes RPS3
T129 212-213 -RRB- denotes )
T130 214-216 VB denotes is
T131 217-219 DT denotes an
T132 220-225 NN denotes NF-κB
T133 226-233 NN denotes subunit
T134 234-238 WDT denotes that
T135 239-246 VB denotes directs
T136 247-255 JJ denotes specific
T137 256-260 NN denotes gene
T138 261-274 NN denotes transcription
T139 276-283 RB denotes However
T140 283-284 -COMMA- denotes ,
T141 285-287 PRP denotes it
T142 288-290 VB denotes is
T143 291-298 JJ denotes unknown
T144 299-302 WRB denotes how
T145 303-307 NN denotes RPS3
T146 308-315 JJ denotes nuclear
T147 316-329 NN denotes translocation
T148 330-332 VB denotes is
T149 333-342 VB denotes regulated
T150 344-348 RB denotes Here
T151 349-351 PRP denotes we
T152 352-358 VB denotes report
T153 359-363 IN denotes that
T154 364-368 NN denotes IKKβ
T155 369-384 NN denotes phosphorylation
T156 385-387 IN denotes of
T157 388-394 NN denotes serine
T158 395-398 CD denotes 209
T159 399-400 -LRB- denotes (
T160 400-404 NN denotes S209
T161 404-405 -RRB- denotes )
T162 406-409 VB denotes was
T163 410-417 JJ denotes crucial
T164 418-421 IN denotes for
T165 422-426 NN denotes RPS3
T166 427-434 JJ denotes nuclear
T167 435-447 NN denotes localization
T168 448-450 IN denotes in
T169 451-459 NN denotes response
T170 460-462 TO denotes to
T171 463-473 VB denotes activating
T172 474-481 NN denotes stimuli
T173 483-491 RB denotes Moreover
T174 491-492 -COMMA- denotes ,
T175 493-496 DT denotes the
T176 497-506 JJ denotes foodborne
T177 507-515 NN denotes pathogen
T178 516-527 FW denotes Escherichia
T179 528-532 FW denotes coli
T180 533-537 NN denotes O157
T181 537-538 -COLON- denotes :
T182 538-540 NN denotes H7
T183 541-550 NN denotes virulence
T184 551-558 NN denotes protein
T185 559-564 NN denotes NleH1
T186 565-577 RB denotes specifically
T187 578-587 VB denotes inhibited
T188 588-592 NN denotes RPS3
T189 593-597 NN denotes S209
T190 598-613 NN denotes phosphorylation
T191 614-617 CC denotes and
T192 618-625 VB denotes blocked
T193 626-630 NN denotes RPS3
T194 631-639 NN denotes function
T195 639-640 -COMMA- denotes ,
T196 641-648 RB denotes thereby
T197 649-658 VB denotes promoting
T198 659-668 JJ denotes bacterial
T199 669-681 NN denotes colonization
T200 682-685 CC denotes and
T201 686-694 NN denotes diarrhea
T202 695-698 CC denotes but
T203 699-709 VB denotes decreasing
T204 710-719 NN denotes mortality
T205 720-722 IN denotes in
T206 723-724 DT denotes a
T207 725-736 JJ denotes gnotobiotic
T208 737-743 NN denotes piglet
T209 744-753 NN denotes infection
T210 754-759 NN denotes model
T211 761-765 RB denotes Thus
T212 765-766 -COMMA- denotes ,
T213 767-770 DT denotes the
T214 771-785 JJ denotes IKKβ-dependent
T215 786-798 NN denotes modification
T216 799-801 IN denotes of
T217 802-803 DT denotes a
T218 804-812 JJ denotes specific
T219 813-818 NN denotes amino
T220 819-823 NN denotes acid
T221 824-826 IN denotes in
T222 827-831 NN denotes RPS3
T223 832-840 VB denotes promotes
T224 841-849 JJ denotes specific
T225 850-855 NN denotes NF-κB
T226 856-865 NN denotes functions
T227 866-870 WDT denotes that
T228 871-879 VB denotes underlie
T229 880-883 DT denotes the
T230 884-893 JJ denotes molecular
T231 894-906 JJ denotes pathogenetic
T232 907-917 NN denotes mechanisms
T233 918-920 IN denotes of
T234 921-923 FW denotes E.
T235 924-928 FW denotes coli
T236 929-933 NN denotes O157
T237 933-934 -COLON- denotes :
T238 934-936 NN denotes H7
T793 939-946 JJ denotes Nuclear
T794 947-959 NN denotes Factor-kappa
T795 960-961 NN denotes B
T796 962-963 -LRB- denotes (
T797 963-968 NN denotes NF-κB
T798 968-969 -RRB- denotes )
T799 970-979 VB denotes regulates
T800 980-987 JJ denotes crucial
T801 988-996 JJ denotes cellular
T802 997-1006 NN denotes functions
T803 1007-1010 CC denotes and
T804 1011-1018 JJ denotes diverse
T805 1019-1026 NN denotes stimuli
T806 1027-1035 VB denotes activate
T807 1036-1040 DT denotes this
T808 1041-1052 JJ denotes pleiotropic
T809 1053-1066 NN denotes transcription
T810 1067-1073 NN denotes factor
T811 1073-1074 -COMMA- denotes ,
T812 1075-1080 WDT denotes which
T813 1081-1083 IN denotes in
T814 1084-1088 NN denotes turn
T815 1089-1098 VB denotes regulates
T816 1099-1100 DT denotes a
T817 1101-1105 JJ denotes vast
T818 1106-1111 NN denotes array
T819 1112-1114 IN denotes of
T820 1115-1122 JJ denotes genetic
T821 1123-1133 NN denotes targets1-3
T822 1135-1138 DT denotes The
T823 1139-1149 JJ denotes best-known
T824 1150-1159 JJ denotes mammalian
T825 1160-1165 NN denotes NF-κB
T826 1166-1174 NN denotes subunits
T827 1175-1178 VB denotes are
T828 1179-1182 NN denotes Rel
T829 1183-1191 NN denotes proteins
T830 1191-1192 -COMMA- denotes ,
T831 1193-1202 VB denotes including
T832 1203-1207 NN denotes RelA
T833 1208-1209 -LRB- denotes (
T834 1209-1212 NN denotes p65
T835 1212-1213 -RRB- denotes )
T836 1213-1214 -COMMA- denotes ,
T837 1215-1219 NN denotes RelB
T838 1219-1220 -COMMA- denotes ,
T839 1221-1226 NN denotes c-Rel
T840 1226-1227 -COMMA- denotes ,
T841 1228-1231 NN denotes p50
T842 1231-1232 -COMMA- denotes ,
T843 1233-1236 CC denotes and
T844 1237-1240 NN denotes p52
T845 1241-1242 -LRB- denotes (
T846 1242-1246 NN denotes refs
T847 1248-1252 CD denotes 4, 5
T848 1252-1253 -RRB- denotes )
T849 1255-1262 RB denotes However
T850 1262-1263 -COMMA- denotes ,
T851 1264-1266 PRP denotes we
T852 1267-1275 RB denotes recently
T853 1276-1288 VB denotes demonstrated
T854 1289-1293 IN denotes that
T855 1294-1303 JJ denotes ribosomal
T856 1304-1311 NN denotes protein
T857 1312-1314 NN denotes S3
T858 1315-1316 -LRB- denotes (
T859 1316-1320 NN denotes RPS3
T860 1320-1321 -RRB- denotes )
T861 1322-1324 VB denotes is
T862 1325-1326 DT denotes a
T863 1327-1330 JJ denotes key
T864 1331-1338 JJ denotes non-Rel
T865 1339-1346 NN denotes subunit
T866 1347-1349 IN denotes of
T867 1350-1357 JJ denotes certain
T868 1358-1364 JJ denotes native
T869 1365-1370 NN denotes NF-κB
T870 1371-1381 NN denotes complexes6
T871 1383-1387 NN denotes RPS3
T872 1388-1390 VB denotes is
T873 1391-1398 VB denotes defined
T874 1399-1401 IN denotes as
T875 1402-1403 DT denotes a
T876 1404-1415 JJ denotes “specifier”
T877 1416-1423 NN denotes subunit
T878 1424-1426 IN denotes of
T879 1427-1432 NN denotes NF-κB
T880 1432-1433 -COMMA- denotes ,
T881 1434-1441 IN denotes because
T882 1442-1444 PRP denotes it
T883 1445-1456 VB denotes facilitates
T884 1457-1461 JJ denotes high
T885 1462-1470 NN denotes affinity
T886 1471-1474 NN denotes DNA
T887 1475-1482 NN denotes binding
T888 1483-1487 RB denotes thus
T889 1488-1499 VB denotes determining
T890 1500-1503 DT denotes the
T891 1504-1514 JJ denotes regulatory
T892 1515-1526 NN denotes specificity
T893 1527-1529 IN denotes of
T894 1530-1535 NN denotes NF-κB
T895 1536-1539 IN denotes for
T896 1540-1548 VB denotes selected
T897 1549-1555 NN denotes target
T898 1556-1562 NN denotes genes7
T899 1564-1568 NN denotes RPS3
T900 1569-1579 NN denotes regulation
T901 1580-1582 IN denotes of
T902 1583-1588 NN denotes NF-κB
T903 1589-1596 NN denotes governs
T904 1597-1600 JJ denotes key
T905 1601-1614 JJ denotes physiological
T906 1615-1624 NN denotes processes
T907 1624-1625 -COMMA- denotes ,
T908 1626-1635 VB denotes including
T909 1636-1650 NN denotes immunoglobulin
T910 1651-1652 JJ denotes κ
T911 1653-1658 JJ denotes light
T912 1659-1664 NN denotes chain
T913 1665-1669 NN denotes gene
T914 1670-1680 NN denotes expression
T915 1681-1684 CC denotes and
T916 1685-1693 NN denotes receptor
T917 1694-1701 NN denotes editing
T918 1702-1704 IN denotes in
T919 1705-1706 NN denotes B
T920 1707-1716 NN denotes cells6, 8
T921 1716-1717 -COMMA- denotes ,
T922 1718-1726 NN denotes cytokine
T923 1727-1737 NN denotes production
T924 1738-1740 IN denotes in
T925 1741-1742 NN denotes T
T926 1743-1749 NN denotes cells6
T927 1749-1750 -COMMA- denotes ,
T928 1751-1754 CC denotes and
T929 1755-1757 IN denotes in
T930 1758-1762 NN denotes host
T931 1763-1770 NN denotes defense
T932 1771-1778 IN denotes against
T933 1779-1808 FW denotes enterohemorrhagic Escherichia
T934 1809-1813 FW denotes coli
T935 1814-1815 -LRB- denotes (
T936 1815-1819 NN denotes EHEC
T937 1819-1820 -RRB- denotes )
T938 1820-1821 CD denotes 9
T939 1823-1825 IN denotes In
T940 1826-1836 JJ denotes particular
T941 1836-1837 -COMMA- denotes ,
T942 1838-1844 NNP denotes the E.
T943 1845-1854 NN denotes coli O157
T944 1854-1855 -COLON- denotes :
T945 1855-1857 NN denotes H7
T946 1858-1862 NN denotes type
T947 1863-1866 CD denotes III
T948 1867-1876 NN denotes secretion
T949 1877-1883 NN denotes system
T950 1884-1885 -LRB- denotes (
T951 1885-1889 NN denotes T3SS
T952 1889-1890 -RRB- denotes )
T953 1891-1899 NN denotes effector
T954 1900-1907 NN denotes protein
T955 1908-1913 NN denotes NleH1
T956 1914-1925 RB denotes selectively
T957 1926-1932 VB denotes blocks
T958 1933-1938 NN denotes NF-κB
T959 1939-1945 NN denotes target
T960 1946-1950 NN denotes gene
T961 1951-1964 NN denotes transcription
T962 1965-1967 IN denotes by
T963 1968-1979 VB denotes attenuating
T964 1980-1984 NN denotes RPS3
T965 1985-1992 JJ denotes nuclear
T966 1993-2006 NN denotes translocation
T967 2006-2007 -COMMA- denotes ,
T968 2008-2015 IN denotes without
T969 2016-2025 VB denotes affecting
T970 2026-2029 NN denotes p65
T971 2030-2043 NN denotes localization9
T972 2045-2056 RB denotes Nonetheless
T973 2056-2057 -COMMA- denotes ,
T974 2058-2061 WRB denotes how
T975 2062-2070 JJ denotes specific
T976 2071-2076 NN denotes NF-κB
T977 2077-2087 NN denotes activating
T978 2088-2095 NN denotes signals
T979 2096-2102 VB denotes induce
T980 2103-2107 NN denotes RPS3
T981 2108-2115 JJ denotes nuclear
T982 2116-2129 NN denotes translocation
T983 2130-2132 VB denotes is
T984 2133-2157 JJ denotes unknown. Extra-ribosomal
T985 2158-2167 NN denotes functions
T986 2168-2172 VB denotes have
T987 2173-2177 VB denotes been
T988 2178-2186 VB denotes ascribed
T989 2187-2189 TO denotes to
T990 2190-2199 JJ denotes ribosomal
T991 2200-2210 NN denotes proteins10
T992 2212-2219 IN denotes Besides
T993 2220-2227 NN denotes binding
T994 2228-2231 NN denotes RNA
T995 2232-2238 IN denotes within
T996 2239-2242 DT denotes the
T997 2243-2246 NN denotes 40S
T998 2247-2256 JJ denotes ribosomal
T999 2257-2264 NN denotes subunit
T1000 2264-2265 -COMMA- denotes ,
T1001 2266-2270 NN denotes RPS3
T1002 2271-2283 VB denotes participates
T1003 2284-2286 IN denotes in
T1004 2287-2301 NN denotes transcription6
T1005 2301-2302 -COMMA- denotes ,
T1006 2303-2306 NN denotes DNA
T1007 2307-2319 NN denotes repair11, 12
T1008 2319-2320 -COMMA- denotes ,
T1009 2321-2324 CC denotes and
T1010 2325-2336 NN denotes apoptosis13
T1011 2338-2345 IN denotes Whether
T1012 2346-2348 CC denotes or
T1013 2349-2352 RB denotes not
T1014 2353-2357 NN denotes RPS3
T1015 2358-2360 VB denotes is
T1016 2361-2375 VB denotes phosphorylated
T1017 2376-2379 VB denotes had
T1018 2380-2384 VB denotes been
T1019 2385-2403 JJ denotes controversial14-18
T1020 2405-2410 IN denotes Since
T1021 2411-2417 NN denotes kinase
T1022 2418-2426 NN denotes cascades
T1023 2427-2431 VB denotes play
T1024 2432-2433 DT denotes a
T1025 2434-2442 JJ denotes critical
T1026 2443-2447 NN denotes role
T1027 2448-2450 IN denotes in
T1028 2451-2456 NN denotes NF-κB
T1029 2457-2467 NN denotes regulation
T1030 2467-2468 -COMMA- denotes ,
T1031 2469-2471 PRP denotes we
T1032 2472-2478 VB denotes tested
T1033 2479-2486 IN denotes whether
T1034 2487-2491 NN denotes RPS3
T1035 2492-2494 VB denotes is
T1036 2495-2509 VB denotes phosphorylated
T1037 2510-2512 IN denotes in
T1038 2513-2516 DT denotes the
T1039 2517-2524 NN denotes context
T1040 2525-2527 IN denotes of
T1041 2528-2533 NN denotes NF-κB
T1042 2534-2544 NN denotes activation
T1043 2545-2548 CC denotes and
T1044 2549-2555 VB denotes sought
T1045 2556-2558 TO denotes to
T1046 2559-2567 VB denotes identify
T1047 2568-2571 DT denotes the
T1048 2572-2583 JJ denotes responsible
T1049 2584-2592 NN denotes kinase19
T1050 2594-2606 RB denotes Additionally
T1051 2606-2607 -COMMA- denotes ,
T1052 2608-2610 PRP denotes we
T1053 2611-2616 VB denotes aimed
T1054 2617-2619 TO denotes to
T1055 2620-2626 VB denotes define
T1056 2627-2628 DT denotes a
T1057 2629-2639 JJ denotes regulatory
T1058 2640-2644 NN denotes role
T1059 2645-2648 IN denotes for
T1060 2649-2652 DT denotes the
T1061 2653-2663 JJ denotes C-terminal
T1062 2664-2668 NN denotes tail
T1063 2669-2671 IN denotes of
T1064 2672-2676 NN denotes RPS3
T1065 2677-2682 WP-DOLLAR- denotes whose
T1066 2683-2691 NN denotes function
T1067 2692-2695 VB denotes was
T1068 2696-2709 JJ denotes unknown. Here
T1069 2710-2712 PRP denotes we
T1070 2713-2717 VB denotes show
T1071 2718-2722 IN denotes that
T1072 2723-2726 DT denotes the
T1073 2727-2736 NN denotes Inhibitor
T1074 2737-2739 IN denotes of
T1075 2740-2742 NN denotes κB
T1076 2743-2744 -LRB- denotes (
T1077 2744-2747 NN denotes IκB
T1078 2747-2748 -RRB- denotes )
T1079 2749-2755 NN denotes kinase
T1080 2756-2760 NN denotes beta
T1081 2761-2762 -LRB- denotes (
T1082 2762-2766 NN denotes IKKβ
T1083 2766-2767 -RRB- denotes )
T1084 2768-2782 VB denotes phosphorylated
T1085 2783-2787 NN denotes RPS3
T1086 2788-2790 IN denotes at
T1087 2791-2797 NN denotes serine
T1088 2798-2801 CD denotes 209
T1089 2802-2803 -LRB- denotes (
T1090 2803-2807 NN denotes S209
T1091 2807-2808 -RRB- denotes )
T1092 2810-2814 NN denotes RPS3
T1093 2815-2819 NN denotes S209
T1094 2820-2835 NN denotes phosphorylation
T1095 2836-2844 VB denotes enhanced
T1096 2845-2848 PRP-DOLLAR- denotes its
T1097 2849-2860 NN denotes association
T1098 2861-2865 IN denotes with
T1099 2866-2876 NN denotes importin-α
T1100 2876-2877 -COMMA- denotes ,
T1101 2878-2887 VB denotes mediating
T1102 2888-2892 NN denotes RPS3
T1103 2893-2898 NN denotes entry
T1104 2899-2903 IN denotes into
T1105 2904-2907 DT denotes the
T1106 2908-2919 NN denotes karyopherin
T1107 2920-2927 NN denotes pathway
T1108 2928-2931 IN denotes for
T1109 2932-2939 JJ denotes nuclear
T1110 2940-2953 NN denotes translocation
T1111 2955-2966 RB denotes Furthermore
T1112 2966-2967 -COMMA- denotes ,
T1113 2968-2974 NN denotes the E.
T1114 2975-2985 NN denotes coli NleH1
T1115 2986-2994 NN denotes effector
T1116 2995-3007 RB denotes specifically
T1117 3008-3017 VB denotes inhibited
T1118 3018-3022 NN denotes RPS3
T1119 3023-3027 NN denotes S209
T1120 3028-3037 VB denotes revealing
T1121 3038-3044 NN denotes how E.
T1122 3045-3054 NN denotes coli O157
T1123 3054-3055 -COLON- denotes :
T1124 3055-3057 NN denotes H7
T1125 3058-3066 VB denotes inhibits
T1126 3067-3071 DT denotes this
T1127 3072-3081 JJ denotes important
T1128 3082-3088 JJ denotes innate
T1129 3089-3095 JJ denotes immune
T1130 3096-3104 NN denotes response
T1131 3105-3114 NN denotes mechanism
T2017 3126-3130 NN denotes RPS3
T2018 3131-3146 NN denotes phosphorylation
T2019 3147-3149 IN denotes in
T2020 3150-3158 NN denotes response
T2021 3159-3161 TO denotes to
T2022 3162-3167 NN denotes NF-κB
T2023 3168-3178 NN denotes activation
T2024 3179-3181 TO denotes To
T2025 3182-3186 VB denotes test
T2026 3187-3194 IN denotes whether
T2027 3195-3199 NN denotes RPS3
T2028 3200-3202 VB denotes is
T2029 3203-3217 VB denotes phosphorylated
T2030 3218-3224 IN denotes during
T2031 3225-3230 NN denotes NF-κB
T2032 3231-3241 NN denotes activation
T2033 3241-3242 -COMMA- denotes ,
T2034 3243-3245 PRP denotes we
T2035 3246-3255 VB denotes performed
T2036 3256-3268 JJ denotes 32P-labeling
T2037 3269-3280 NN denotes experiments
T2038 3281-3283 IN denotes in
T2039 3284-3289 NN denotes tumor
T2040 3290-3298 NN denotes necrosis
T2041 3299-3305 NN denotes factor
T2042 3306-3307 -LRB- denotes (
T2043 3307-3310 NN denotes TNF
T2044 3310-3311 -RRB- denotes )
T2045 3311-3322 JJ denotes -stimulated
T2046 3323-3326 NN denotes HEK
T2047 3327-3331 NN denotes 293T
T2048 3332-3337 NN denotes cells
T2049 3339-3344 IN denotes While
T2050 3345-3349 NN denotes RPS3
T2051 3350-3353 VB denotes was
T2052 3354-3362 RB denotes scarcely
T2053 3363-3377 VB denotes phosphorylated
T2054 3378-3380 IN denotes in
T2055 3381-3393 JJ denotes unstimulated
T2056 3394-3399 NN denotes cells
T2057 3399-3400 -COMMA- denotes ,
T2058 3401-3403 PRP denotes we
T2059 3404-3412 VB denotes observed
T2060 3413-3414 DT denotes a
T2061 3415-3421 JJ denotes marked
T2062 3422-3430 NN denotes increase
T2063 3431-3433 IN denotes in
T2064 3434-3451 NN denotes 32P-incorporation
T2065 3452-3457 IN denotes after
T2066 3458-3461 NN denotes TNF
T2067 3462-3473 NN denotes stimulation
T2068 3474-3481 IN denotes despite
T2069 3482-3484 DT denotes no
T2070 3485-3493 NN denotes increase
T2071 3494-3496 IN denotes in
T2072 3497-3501 NN denotes RPS3
T2073 3502-3509 NN denotes protein
T2074 3510-3511 -LRB- denotes (
T2075 3511-3515 NN denotes Fig.
T2076 3516-3518 NN denotes 1a
T2077 3518-3519 -RRB- denotes )
T2078 3521-3523 TO denotes To
T2079 3524-3533 VB denotes determine
T2080 3534-3539 WDT denotes which
T2081 3540-3544 NN denotes RPS3
T2082 3545-3553 NN denotes residues
T2083 3554-3558 VB denotes were
T2084 3559-3573 VB denotes phosphorylated
T2085 3573-3574 -COMMA- denotes ,
T2086 3575-3577 PRP denotes we
T2087 3578-3596 VB denotes immunoprecipitated
T2088 3597-3601 NN denotes RPS3
T2089 3602-3606 IN denotes from
T2090 3607-3613 CC denotes either
T2091 3614-3621 VB denotes resting
T2092 3622-3624 CC denotes or
T2093 3625-3635 VB denotes stimulated
T2094 3636-3641 NN denotes cells
T2095 3642-3645 CC denotes and
T2096 3646-3655 VB denotes performed
T2097 3656-3670 NN denotes immunoblotting
T2098 3671-3675 IN denotes with
T2099 3676-3700 JJ denotes phosphorylation-specific
T2100 3701-3711 NN denotes antibodies
T2101 3713-3717 CC denotes Both
T2102 3718-3721 NN denotes TNF
T2103 3722-3725 CC denotes and
T2104 3726-3733 NN denotes phorbol
T2105 3734-3743 NN denotes myristate
T2106 3744-3761 NN denotes acetate/ionomycin
T2107 3762-3763 -LRB- denotes (
T2108 3763-3768 NN denotes PMA+I
T2109 3768-3769 -RRB- denotes )
T2110 3770-3780 VB denotes stimulated
T2111 3781-3786 JJ denotes rapid
T2112 3787-3802 NN denotes phosphorylation
T2113 3803-3806 CC denotes and
T2114 3807-3817 NN denotes degradaion
T2115 3818-3820 IN denotes of
T2116 3821-3825 NN denotes IκBα
T2117 3826-3832 IN denotes within
T2118 3833-3834 CD denotes 5
T2119 3835-3838 NN denotes min
T2120 3839-3844 WDT denotes which
T2121 3845-3848 VB denotes was
T2122 3849-3860 VB denotes accompanied
T2123 3861-3863 IN denotes by
T2124 3864-3868 NN denotes RPS3
T2125 3869-3884 NN denotes phosphorylation
T2126 3885-3887 IN denotes on
T2127 3888-3894 NN denotes serine
T2128 3895-3903 NN denotes residues
T2129 3904-3905 -LRB- denotes (
T2130 3905-3909 NN denotes Fig.
T2131 3910-3912 NN denotes 1b
T2132 3913-3916 CC denotes and
T2133 3917-3921 NN denotes data
T2134 3922-3925 RB denotes not
T2135 3926-3931 VB denotes shown
T2136 3931-3932 -RRB- denotes )
T2137 3932-3933 -COMMA- denotes ,
T2138 3934-3941 JJ denotes similar
T2139 3942-3944 TO denotes to
T2140 3945-3948 DT denotes the
T2141 3949-3951 FW denotes in
T2142 3952-3956 FW denotes vivo
T2143 3957-3965 NN denotes labeling
T2144 3967-3969 PRP denotes We
T2145 3970-3973 VB denotes did
T2146 3974-3977 RB denotes not
T2147 3978-3984 VB denotes detect
T2148 3985-3994 NN denotes tyrosine-
T2149 3995-3997 CC denotes or
T2150 3998-4023 NN denotes threonine-phosphorylation
T2151 4024-4026 IN denotes of
T2152 4027-4031 NN denotes RPS3
T2153 4032-4033 -LRB- denotes (
T2154 4033-4037 NN denotes Fig.
T2155 4038-4040 NN denotes 1b
T2156 4040-4041 -RRB- denotes )
T2641 4044-4048 NN denotes RPS3
T2642 4049-4052 CC denotes and
T2643 4053-4057 NN denotes IKKβ
T2644 4058-4069 NN denotes interaction
T2645 4070-4073 DT denotes The
T2646 4074-4084 NN denotes activation
T2647 4085-4087 IN denotes of
T2648 4088-4091 DT denotes the
T2649 4092-4101 NN denotes inhibitor
T2650 4102-4104 IN denotes of
T2651 4105-4107 NN denotes κB
T2652 4108-4114 NN denotes kinase
T2653 4115-4116 -LRB- denotes (
T2654 4116-4119 NN denotes IKK
T2655 4119-4120 -RRB- denotes )
T2656 4120-4121 -COMMA- denotes ,
T2657 4122-4132 VB denotes consisting
T2658 4133-4135 IN denotes of
T2659 4136-4137 DT denotes a
T2660 4138-4148 JJ denotes regulatory
T2661 4149-4156 NN denotes subunit
T2662 4157-4161 NN denotes IKKγ
T2663 4162-4165 CC denotes and
T2664 4166-4169 CD denotes two
T2665 4170-4179 JJ denotes catalytic
T2666 4180-4188 NN denotes subunits
T2667 4188-4189 -COMMA- denotes ,
T2668 4190-4194 NN denotes IKKα
T2669 4195-4198 CC denotes and
T2670 4199-4203 NN denotes IKKβ
T2671 4203-4204 -COMMA- denotes ,
T2672 4205-4207 VB denotes is
T2673 4208-4216 JJ denotes critical
T2674 4217-4220 IN denotes for
T2675 4221-4224 DT denotes the
T2676 4225-4240 NN denotes phosphorylation
T2677 4241-4244 CC denotes and
T2678 4245-4253 NN denotes dispatch
T2679 4254-4256 IN denotes of
T2680 4257-4260 DT denotes the
T2681 4261-4271 JJ denotes inhibitory
T2682 4272-4276 NN denotes IκBs
T2683 4277-4280 CC denotes and
T2684 4281-4284 DT denotes the
T2685 4285-4295 NN denotes liberation
T2686 4296-4298 IN denotes of
T2687 4299-4309 NN denotes NF-κB20-22
T2688 4311-4316 VB denotes Given
T2689 4317-4321 IN denotes that
T2690 4322-4326 NN denotes RPS3
T2691 4327-4330 MD denotes can
T2692 4331-4333 VB denotes be
T2693 4334-4339 VB denotes found
T2694 4340-4342 IN denotes in
T2695 4343-4346 DT denotes the
T2696 4347-4358 JJ denotes cytoplasmic
T2697 4359-4371 NN denotes p65-p50-IκBα
T2698 4372-4382 JJ denotes inhibitory
T2699 4383-4390 NN denotes complex
T2700 4391-4393 IN denotes in
T2701 4394-4401 VB denotes resting
T2702 4402-4408 NN denotes cells6
T2703 4408-4409 -COMMA- denotes ,
T2704 4410-4412 PRP denotes we
T2705 4413-4425 VB denotes hypothesized
T2706 4426-4430 IN denotes that
T2707 4431-4440 VB denotes activated
T2708 4441-4445 NN denotes IKKβ
T2709 4446-4451 MD denotes might
T2710 4452-4456 RB denotes also
T2711 4457-4461 VB denotes bind
T2712 4462-4464 TO denotes to
T2713 4465-4468 CC denotes and
T2714 4469-4482 VB denotes phosphorylate
T2715 4483-4487 NN denotes RPS3
T2716 4489-4494 RB denotes First
T2717 4494-4495 -COMMA- denotes ,
T2718 4496-4498 PRP denotes we
T2719 4499-4504 VB denotes found
T2720 4505-4509 IN denotes that
T2721 4510-4521 RB denotes ectopically
T2722 4522-4531 VB denotes expressed
T2723 4532-4536 NN denotes IKKβ
T2724 4537-4540 CC denotes and
T2725 4541-4545 NN denotes RPS3
T2726 4546-4556 VB denotes interacted
T2727 4557-4558 -LRB- denotes (
T2728 4558-4562 NNP denotes Fig.
T2729 4563-4565 NN denotes 1c
T2730 4565-4566 -RRB- denotes )
T2731 4568-4570 PRP denotes We
T2732 4571-4575 RB denotes next
T2733 4576-4584 VB denotes examined
T2734 4585-4592 VB denotes resting
T2735 4593-4599 NN denotes Jurkat
T2736 4600-4605 NN denotes cells
T2737 4606-4609 CC denotes and
T2738 4610-4618 VB denotes detected
T2739 4619-4620 DT denotes a
T2740 4621-4627 JJ denotes modest
T2741 4628-4638 JJ denotes endogenous
T2742 4639-4648 NN denotes IKKβ-RPS3
T2743 4649-4660 NN denotes interaction
T2744 4661-4662 -LRB- denotes (
T2745 4662-4666 NNP denotes Fig.
T2746 4667-4669 NN denotes 1d
T2747 4669-4670 -RRB- denotes )
T2748 4670-4671 -COMMA- denotes ,
T2749 4672-4683 RB denotes potentially
T2750 4684-4694 VB denotes accounting
T2751 4695-4698 IN denotes for
T2752 4699-4702 DT denotes the
T2753 4703-4708 JJ denotes basal
T2754 4709-4714 NN denotes NF-κB
T2755 4715-4728 NN denotes transcription
T2756 4729-4737 VB denotes required
T2757 4738-4741 IN denotes for
T2758 4742-4746 NN denotes cell
T2759 4747-4760 NN denotes proliferation
T2760 4761-4764 CC denotes and
T2761 4765-4773 NN denotes survival
T2762 4775-4784 NN denotes RPS3-IKKβ
T2763 4785-4796 NN denotes association
T2764 4797-4800 VB denotes was
T2765 4801-4808 RB denotes clearly
T2766 4809-4818 VB denotes augmented
T2767 4819-4823 IN denotes upon
T2768 4824-4827 NN denotes TNF
T2769 4828-4839 NN denotes stimulation
T2770 4839-4840 -COMMA- denotes ,
T2771 4841-4848 VB denotes peaking
T2772 4849-4851 IN denotes at
T2773 4852-4854 CD denotes 10
T2774 4855-4859 NN denotes min.
T2775 4860-4861 -LRB- denotes (
T2776 4861-4865 NNP denotes Fig.
T2777 4866-4868 NN denotes 1d
T2778 4868-4869 -RRB- denotes )
T2779 4869-4870 -COMMA- denotes ,
T2780 4871-4880 VB denotes following
T2781 4881-4888 JJ denotes similar
T2782 4889-4897 NN denotes kinetics
T2783 4898-4900 TO denotes to
T2784 4901-4905 NN denotes RPS3
T2785 4906-4912 NN denotes serine
T2786 4913-4928 NN denotes phosphorylation
T2787 4929-4930 -LRB- denotes (
T2788 4930-4934 NN denotes Fig.
T2789 4935-4937 NN denotes 1b
T2790 4937-4938 -RRB- denotes )
T2791 4940-4942 IN denotes By
T2792 4943-4951 NN denotes contrast
T2793 4951-4952 -COMMA- denotes ,
T2794 4953-4958 EX denotes there
T2795 4959-4962 VB denotes was
T2796 4963-4965 DT denotes no
T2797 4966-4976 JJ denotes detectable
T2798 4977-4988 NN denotes interaction
T2799 4989-4996 IN denotes between
T2800 4997-5001 NN denotes RPS3
T2801 5002-5005 CC denotes and
T2802 5006-5010 NN denotes IKKα
T2803 5011-5012 -LRB- denotes (
T2804 5012-5016 NNP denotes Fig.
T2805 5017-5019 NN denotes 1d
T2806 5019-5020 -RRB- denotes )
T3544 5023-5027 NN denotes IKKβ
T3545 5028-5030 VB denotes is
T3546 5031-5039 VB denotes required
T3547 5040-5043 IN denotes for
T3548 5044-5048 NN denotes RPS3
T3549 5049-5056 JJ denotes nuclear
T3550 5057-5070 NN denotes translocation
T3551 5071-5073 TO denotes To
T3552 5074-5081 VB denotes examine
T3553 5082-5089 IN denotes whether
T3554 5090-5093 DT denotes the
T3555 5094-5103 JJ denotes RPS3-IKKβ
T3556 5104-5115 NN denotes interaction
T3557 5116-5118 VB denotes is
T3558 5119-5127 VB denotes required
T3559 5128-5131 IN denotes for
T3560 5132-5136 NN denotes RPS3
T3561 5137-5144 JJ denotes nuclear
T3562 5145-5158 NN denotes translocation
T3563 5158-5159 -COMMA- denotes ,
T3564 5160-5162 PRP denotes we
T3565 5163-5170 VB denotes knocked
T3566 5171-5175 RB denotes down
T3567 5176-5180 NN denotes IKKα
T3568 5181-5183 CC denotes or
T3569 5184-5188 NN denotes IKKβ
T3570 5189-5199 NN denotes expression
T3571 5200-5204 IN denotes with
T3572 5205-5211 NN denotes siRNAs
T3573 5212-5213 -LRB- denotes (
T3574 5213-5226 NNP denotes Supplementary
T3575 5227-5231 NNP denotes Fig.
T3576 5232-5233 CD denotes 1
T3577 5233-5234 -RRB- denotes )
T3578 5235-5238 CC denotes and
T3579 5239-5243 RB denotes then
T3580 5244-5252 VB denotes observed
T3581 5253-5272 JJ denotes stimulation-induced
T3582 5273-5277 NN denotes RPS3
T3583 5278-5285 JJ denotes nuclear
T3584 5286-5295 NN denotes migration
T3585 5296-5298 IN denotes by
T3586 5299-5307 JJ denotes confocal
T3587 5308-5318 NN denotes microscopy
T3588 5320-5324 CC denotes Both
T3589 5325-5328 NN denotes TNF
T3590 5329-5332 CC denotes and
T3591 5333-5338 NN denotes PMA+I
T3592 5339-5348 VB denotes triggered
T3593 5349-5353 NN denotes RPS3
T3594 5354-5361 JJ denotes nuclear
T3595 5362-5375 NN denotes translocation
T3596 5376-5378 IN denotes in
T3597 5379-5385 NN denotes Jurkat
T3598 5386-5391 NN denotes cells
T3599 5392-5403 VB denotes transfected
T3600 5404-5408 IN denotes with
T3601 5409-5410 DT denotes a
T3602 5411-5420 VB denotes scrambled
T3603 5421-5432 JJ denotes nonspecific
T3604 5433-5434 -LRB- denotes (
T3605 5434-5436 NN denotes NS
T3606 5436-5437 -RRB- denotes )
T3607 5438-5443 NN denotes siRNA
T3608 5444-5445 -LRB- denotes (
T3609 5445-5449 NN denotes Fig.
T3610 5450-5452 NN denotes 2a
T3611 5452-5453 -RRB- denotes )
T3612 5453-5454 CD denotes 6
T3613 5456-5460 NN denotes RPS3
T3614 5461-5468 JJ denotes nuclear
T3615 5469-5482 NN denotes translocation
T3616 5483-5486 VB denotes was
T3617 5487-5491 RB denotes only
T3618 5492-5500 RB denotes slightly
T3619 5500-5501 -COMMA- denotes ,
T3620 5502-5504 IN denotes if
T3621 5505-5507 IN denotes at
T3622 5508-5511 DT denotes all
T3623 5511-5512 -COMMA- denotes ,
T3624 5513-5521 VB denotes impaired
T3625 5522-5524 IN denotes by
T3626 5525-5539 NN denotes IKKα-silencing
T3627 5541-5551 RB denotes Conversely
T3628 5551-5552 -COMMA- denotes ,
T3629 5553-5562 NN denotes knockdown
T3630 5563-5565 IN denotes of
T3631 5566-5570 NN denotes IKKβ
T3632 5571-5581 VB denotes attenuated
T3633 5582-5587 CD denotes 60-70
T3634 5587-5588 NN denotes %
T3635 5589-5591 IN denotes of
T3636 5592-5596 NN denotes RPS3
T3637 5597-5604 JJ denotes nuclear
T3638 5605-5617 NN denotes accumulation
T3639 5618-5627 VB denotes following
T3640 5628-5639 NN denotes stimulation
T3641 5640-5641 -LRB- denotes (
T3642 5641-5645 NN denotes Fig.
T3643 5646-5648 NN denotes 2a
T3644 5648-5649 -RRB- denotes )
T3645 5651-5665 NN denotes Immunoblotting
T3646 5666-5668 IN denotes of
T3647 5669-5676 JJ denotes nuclear
T3648 5677-5686 NN denotes fractions
T3649 5687-5696 VB denotes confirmed
T3650 5697-5701 IN denotes that
T3651 5702-5706 JJ denotes full
T3652 5707-5717 NN denotes expression
T3653 5718-5720 IN denotes of
T3654 5721-5725 NN denotes IKKβ
T3655 5725-5726 -COMMA- denotes ,
T3656 5727-5730 CC denotes but
T3657 5731-5734 RB denotes not
T3658 5735-5739 NN denotes IKKα
T3659 5739-5740 -COMMA- denotes ,
T3660 5741-5744 VB denotes was
T3661 5745-5754 JJ denotes necessary
T3662 5755-5758 IN denotes for
T3663 5759-5777 JJ denotes activation-induced
T3664 5778-5782 NN denotes RPS3
T3665 5783-5790 JJ denotes nuclear
T3666 5791-5804 NN denotes translocation
T3667 5805-5806 -LRB- denotes (
T3668 5806-5810 NN denotes Fig.
T3669 5811-5813 NN denotes 2b
T3670 5813-5814 -RRB- denotes )
T3671 5816-5823 NN denotes Control
T3672 5824-5835 NN denotes immunoblots
T3673 5836-5844 VB denotes revealed
T3674 5845-5849 IN denotes that
T3675 5850-5853 NN denotes p65
T3676 5854-5861 JJ denotes nuclear
T3677 5862-5875 NN denotes translocation
T3678 5876-5879 VB denotes was
T3679 5880-5887 VB denotes blocked
T3680 5888-5893 IN denotes under
T3681 5894-5897 DT denotes the
T3682 5898-5902 JJ denotes same
T3683 5903-5913 NN denotes conditions
T3684 5914-5915 -LRB- denotes (
T3685 5915-5919 NNP denotes Fig.
T3686 5920-5922 NN denotes 2b
T3687 5922-5923 -RRB- denotes )
T3688 5925-5927 PRP denotes We
T3689 5928-5932 RB denotes next
T3690 5933-5941 VB denotes examined
T3691 5942-5945 DT denotes the
T3692 5946-5953 JJ denotes nuclear
T3693 5954-5967 NN denotes translocation
T3694 5968-5970 IN denotes of
T3695 5971-5975 NN denotes RPS3
T3696 5976-5978 IN denotes in
T3697 5979-5984 NN denotes cells
T3698 5985-5996 RB denotes ectopically
T3699 5997-6007 VB denotes expressing
T3700 6008-6014 CC denotes either
T3701 6015-6026 NN denotes kinase-dead
T3702 6027-6028 -LRB- denotes (
T3703 6028-6032 NN denotes SSAA
T3704 6032-6033 -RRB- denotes )
T3705 6034-6036 CC denotes or
T3706 6037-6058 JJ denotes constitutively-active
T3707 6059-6060 -LRB- denotes (
T3708 6060-6064 NN denotes SSEE
T3709 6064-6065 -RRB- denotes )
T3710 6066-6072 JJ denotes mutant
T3711 6073-6077 NN denotes IKKβ
T3712 6078-6086 NN denotes proteins
T3713 6088-6090 IN denotes As
T3714 6091-6099 VB denotes expected
T3715 6099-6100 -COMMA- denotes ,
T3716 6101-6104 DT denotes the
T3717 6105-6109 NN denotes SSEE
T3718 6109-6110 -COMMA- denotes ,
T3719 6111-6114 CC denotes but
T3720 6115-6118 RB denotes not
T3721 6119-6123 NN denotes SSAA
T3722 6123-6124 -COMMA- denotes ,
T3723 6125-6131 NN denotes mutant
T3724 6132-6134 IN denotes of
T3725 6135-6139 NN denotes IKKβ
T3726 6140-6147 VB denotes induced
T3727 6148-6163 JJ denotes NF-κB-dependent
T3728 6164-6174 NN denotes luciferase
T3729 6175-6183 NN denotes reporter
T3730 6184-6192 NN denotes activity
T3731 6193-6194 -LRB- denotes (
T3732 6194-6198 NNP denotes Fig.
T3733 6199-6201 NN denotes 2c
T3734 6201-6202 -COMMA- denotes ,
T3735 6203-6207 JJ denotes left
T3736 6207-6208 -RRB- denotes )
T3737 6210-6217 IN denotes Whereas
T3738 6218-6222 NN denotes RPS3
T3739 6223-6231 VB denotes remained
T3740 6232-6241 JJ denotes cytosolic
T3741 6242-6244 IN denotes in
T3742 6245-6249 NN denotes IKKβ
T3743 6250-6251 -LRB- denotes (
T3744 6251-6255 NN denotes SSAA
T3745 6255-6256 -RRB- denotes )
T3746 6256-6267 JJ denotes -expressing
T3747 6268-6273 NN denotes cells
T3748 6274-6275 -LRB- denotes (
T3749 6275-6279 NN denotes Fig.
T3750 6280-6282 NN denotes 2c
T3751 6282-6283 -COMMA- denotes ,
T3752 6284-6289 JJ denotes right
T3753 6289-6290 -RRB- denotes )
T3754 6290-6291 -COMMA- denotes ,
T3755 6292-6293 DT denotes a
T3756 6294-6305 JJ denotes substantial
T3757 6306-6316 NN denotes proportion
T3758 6317-6319 IN denotes of
T3759 6320-6324 NN denotes RPS3
T3760 6325-6337 VB denotes translocated
T3761 6338-6340 TO denotes to
T3762 6341-6344 DT denotes the
T3763 6345-6352 NN denotes nucleus
T3764 6353-6355 IN denotes in
T3765 6356-6361 NN denotes cells
T3766 6362-6372 VB denotes expressing
T3767 6373-6377 NN denotes IKKβ
T3768 6378-6379 -LRB- denotes (
T3769 6379-6383 NN denotes SSEE
T3770 6383-6384 -RRB- denotes )
T3771 6385-6386 -LRB- denotes (
T3772 6386-6390 NNP denotes Fig.
T3773 6391-6393 NN denotes 2c
T3774 6393-6394 -COMMA- denotes ,
T3775 6395-6400 JJ denotes right
T3776 6400-6401 -RRB- denotes )
T3777 6403-6406 DT denotes The
T3778 6407-6417 NN denotes percentage
T3779 6418-6420 IN denotes of
T3780 6421-6426 NN denotes cells
T3781 6427-6437 VB denotes containing
T3782 6438-6448 JJ denotes detectable
T3783 6449-6456 JJ denotes nuclear
T3784 6457-6461 NN denotes RPS3
T3785 6462-6471 VB denotes increased
T3786 6472-6478 RB denotes 5-fold
T3787 6479-6481 IN denotes in
T3788 6482-6486 NN denotes IKKβ
T3789 6487-6488 -LRB- denotes (
T3790 6488-6492 NN denotes SSEE
T3791 6492-6493 -RRB- denotes )
T3792 6493-6504 JJ denotes -expressing
T3793 6505-6510 NN denotes cells
T3794 6510-6511 -COMMA- denotes ,
T3795 6512-6515 CC denotes but
T3796 6516-6519 RB denotes not
T3797 6520-6522 IN denotes in
T3798 6523-6527 NN denotes IKKβ
T3799 6528-6529 -LRB- denotes (
T3800 6529-6533 NN denotes SSAA
T3801 6533-6534 -RRB- denotes )
T3802 6534-6545 JJ denotes -expressing
T3803 6546-6550 NN denotes ones
T3804 6551-6552 -LRB- denotes (
T3805 6552-6556 NNP denotes Fig.
T3806 6557-6559 CD denotes 2d
T3807 6560-6563 CC denotes and
T3808 6564-6577 NNP denotes Supplementary
T3809 6578-6582 NNP denotes Fig.
T3810 6583-6584 CD denotes 2
T3811 6584-6585 -RRB- denotes )
T3812 6587-6591 RB denotes Thus
T3813 6591-6592 -COMMA- denotes ,
T3814 6593-6597 NN denotes IKKβ
T3815 6598-6606 NN denotes activity
T3816 6607-6609 VB denotes is
T3817 6610-6619 JJ denotes necessary
T3818 6620-6623 CC denotes and
T3819 6624-6634 JJ denotes sufficient
T3820 6635-6638 IN denotes for
T3821 6639-6643 NN denotes RPS3
T3822 6644-6651 JJ denotes nuclear
T3823 6652-6665 NN denotes translocation
T3824 6666-6668 IN denotes in
T3825 6669-6677 NN denotes response
T3826 6678-6680 TO denotes to
T3827 6681-6686 NN denotes NF-κB
T3828 6687-6697 VB denotes activating
T3829 6698-6705 NN denotes stimuli
T5160 6708-6712 NN denotes IκBα
T5161 6713-6724 NN denotes degradation
T5162 6725-6728 CC denotes and
T5163 6729-6733 NN denotes RPS3
T5164 6734-6741 JJ denotes nuclear
T5165 6742-6755 NN denotes translocation
T5166 6756-6766 NN denotes Importin-α
T5167 6767-6776 VB denotes regulates
T5168 6777-6780 DT denotes the
T5169 6781-6788 JJ denotes nuclear
T5170 6789-6795 NN denotes import
T5171 6796-6798 IN denotes of
T5172 6799-6804 NN denotes NF-κB
T5173 6805-6808 NN denotes Rel
T5174 6809-6819 NN denotes subunits23
T5175 6819-6820 -COMMA- denotes ,
T5176 6821-6823 CD denotes 24
T5177 6825-6829 NN denotes RPS3
T5178 6830-6837 VB denotes harbors
T5179 6838-6839 DT denotes a
T5180 6840-6847 JJ denotes nuclear
T5181 6848-6860 NN denotes localization
T5182 6861-6867 NN denotes signal
T5183 6868-6869 -LRB- denotes (
T5184 6869-6872 NN denotes NLS
T5185 6872-6873 -RRB- denotes )
T5186 6874-6882 NN denotes sequence
T5187 6883-6886 CC denotes and
T5188 6887-6890 PRP-DOLLAR- denotes its
T5189 6891-6898 JJ denotes nuclear
T5190 6899-6912 NN denotes translocation
T5191 6913-6919 VB denotes occurs
T5192 6920-6922 IN denotes in
T5193 6923-6931 NN denotes parallel
T5194 6932-6934 TO denotes to
T5195 6934-6935 -COMMA- denotes ,
T5196 6936-6939 CC denotes but
T5197 6940-6953 RB denotes independently
T5198 6954-6956 IN denotes of
T5199 6956-6957 -COMMA- denotes ,
T5200 6958-6961 NN denotes p65
T5201 6962-6976 NN denotes translocation6
T5202 6978-6980 PRP denotes We
T5203 6981-6991 VB denotes envisioned
T5204 6992-6996 IN denotes that
T5205 6997-7001 NN denotes RPS3
T5206 7002-7007 MD denotes could
T5207 7008-7012 RB denotes also
T5208 7013-7020 VB denotes utilize
T5209 7021-7024 DT denotes the
T5210 7025-7037 JJ denotes importin-α/β
T5211 7038-7045 NN denotes pathway
T5212 7047-7057 JJ denotes Consistent
T5213 7058-7062 IN denotes with
T5214 7063-7067 DT denotes this
T5215 7068-7074 NN denotes notion
T5216 7074-7075 -COMMA- denotes ,
T5217 7076-7080 NN denotes RPS3
T5218 7081-7092 NN denotes association
T5219 7093-7097 IN denotes with
T5220 7098-7108 NN denotes importin-α
T5221 7108-7109 -COMMA- denotes ,
T5222 7110-7113 CC denotes but
T5223 7114-7117 RB denotes not
T5224 7118-7128 JJ denotes importin-β
T5225 7128-7129 -COMMA- denotes ,
T5226 7130-7133 VB denotes was
T5227 7134-7142 VB denotes enhanced
T5228 7143-7145 IN denotes in
T5229 7146-7160 VB denotes TNF–stimulated
T5230 7161-7166 NN denotes cells
T5231 7167-7168 -LRB- denotes (
T5232 7168-7172 NN denotes Fig.
T5233 7173-7175 NN denotes 3a
T5234 7175-7176 -RRB- denotes )
T5235 7178-7187 RB denotes Therefore
T5236 7187-7188 -COMMA- denotes ,
T5237 7189-7191 PRP denotes we
T5238 7192-7200 VB denotes examined
T5239 7201-7208 IN denotes whether
T5240 7209-7213 NN denotes RPS3
T5241 7214-7221 NN denotes binding
T5242 7222-7224 TO denotes to
T5243 7225-7235 NN denotes importin-α
T5244 7236-7238 VB denotes is
T5245 7239-7248 JJ denotes essential
T5246 7249-7252 IN denotes for
T5247 7253-7260 JJ denotes nuclear
T5248 7261-7274 NN denotes translocation
T5249 7275-7281 IN denotes during
T5250 7282-7287 NN denotes NF-κB
T5251 7288-7298 NN denotes activation
T5252 7300-7305 IN denotes Since
T5253 7306-7310 NN denotes IκBα
T5254 7311-7322 NN denotes degradation
T5255 7323-7325 VB denotes is
T5256 7326-7327 DT denotes a
T5257 7328-7340 NN denotes prerequisite
T5258 7341-7343 TO denotes to
T5259 7344-7350 VB denotes unmask
T5260 7351-7354 DT denotes the
T5261 7355-7358 NN denotes NLS
T5262 7359-7361 IN denotes of
T5263 7362-7365 NN denotes p65
T5264 7365-7366 -COMMA- denotes ,
T5265 7367-7370 CC denotes and
T5266 7371-7375 CC denotes both
T5267 7376-7380 NN denotes RPS3
T5268 7381-7384 CC denotes and
T5269 7385-7389 NN denotes IκBα
T5270 7390-7394 VB denotes bind
T5271 7395-7397 TO denotes to
T5272 7398-7401 NN denotes p65
T5273 7402-7404 IN denotes in
T5274 7405-7408 DT denotes the
T5275 7409-7420 JJ denotes cytoplasmic
T5276 7421-7431 JJ denotes inhibitory
T5277 7432-7439 NN denotes complex
T5278 7439-7440 -COMMA- denotes ,
T5279 7441-7443 PRP denotes we
T5280 7444-7450 VB denotes tested
T5281 7451-7458 IN denotes whether
T5282 7459-7463 NN denotes IκBα
T5283 7464-7475 NN denotes degradation
T5284 7476-7478 VB denotes is
T5285 7479-7487 VB denotes required
T5286 7488-7491 IN denotes for
T5287 7492-7495 DT denotes the
T5288 7496-7506 NN denotes liberation
T5289 7507-7509 IN denotes of
T5290 7510-7514 NN denotes RPS3
T5291 7516-7518 PRP denotes We
T5292 7519-7527 VB denotes measured
T5293 7528-7531 DT denotes the
T5294 7532-7543 NN denotes association
T5295 7544-7546 IN denotes of
T5296 7547-7551 NN denotes RPS3
T5297 7552-7556 IN denotes with
T5298 7557-7567 NN denotes importin-α
T5299 7568-7570 IN denotes in
T5300 7571-7575 NN denotes 293T
T5301 7576-7581 NN denotes cells
T5302 7582-7596 VB denotes overexpressing
T5303 7597-7606 JJ denotes wild-type
T5304 7607-7611 NN denotes IκBα
T5305 7612-7614 CC denotes or
T5306 7615-7617 DT denotes an
T5307 7618-7622 NN denotes IκBα
T5308 7623-7629 NN denotes mutant
T5309 7630-7631 -LRB- denotes (
T5310 7631-7635 NN denotes SSAA
T5311 7635-7636 -RRB- denotes )
T5312 7637-7646 JJ denotes resistant
T5313 7647-7649 TO denotes to
T5314 7650-7662 JJ denotes IKKβ-induced
T5315 7663-7678 NN denotes phosphorylation
T5316 7679-7682 CC denotes and
T5317 7683-7694 NN denotes degradation
T5318 7696-7698 IN denotes In
T5319 7699-7704 NN denotes cells
T5320 7705-7716 VB denotes transfected
T5321 7717-7721 IN denotes with
T5322 7722-7731 JJ denotes wild-type
T5323 7732-7736 NN denotes IκBα
T5324 7736-7737 -COMMA- denotes ,
T5325 7738-7741 NN denotes TNF
T5326 7742-7753 NN denotes stimulation
T5327 7754-7763 VB denotes augmented
T5328 7764-7767 DT denotes the
T5329 7768-7779 NN denotes interaction
T5330 7780-7782 IN denotes of
T5331 7783-7787 NN denotes RPS3
T5332 7788-7791 CC denotes and
T5333 7792-7802 JJ denotes importin-α
T5334 7803-7805 TO denotes to
T5335 7806-7807 DT denotes a
T5336 7808-7815 JJ denotes similar
T5337 7816-7822 NN denotes degree
T5338 7823-7825 IN denotes as
T5339 7826-7828 IN denotes in
T5340 7829-7844 JJ denotes non-transfected
T5341 7845-7850 NN denotes cells
T5342 7852-7854 IN denotes By
T5343 7855-7863 NN denotes contrast
T5344 7863-7864 -COMMA- denotes ,
T5345 7865-7867 PRP denotes we
T5346 7868-7876 VB denotes observed
T5347 7877-7881 IN denotes that
T5348 7882-7885 DT denotes the
T5349 7886-7901 NN denotes RPS3-importin-α
T5350 7902-7913 NN denotes association
T5351 7914-7917 VB denotes was
T5352 7918-7927 VB denotes abolished
T5353 7928-7930 IN denotes by
T5354 7931-7934 DT denotes the
T5355 7935-7943 NN denotes presence
T5356 7944-7946 IN denotes of
T5357 7947-7961 JJ denotes non-degradable
T5358 7962-7966 NN denotes IκBα
T5359 7967-7968 -LRB- denotes (
T5360 7968-7972 NN denotes Fig.
T5361 7973-7975 NN denotes 3b
T5362 7975-7976 -RRB- denotes )
T5363 7978-7980 TO denotes To
T5364 7981-7988 VB denotes examine
T5365 7989-7996 IN denotes whether
T5366 7997-8001 NN denotes IκBα
T5367 8002-8004 VB denotes is
T5368 8005-8008 DT denotes the
T5369 8009-8013 RB denotes only
T5370 8014-8025 JJ denotes cytoplasmic
T5371 8026-8033 NN denotes barrier
T5372 8034-8044 VB denotes precluding
T5373 8045-8049 NN denotes RPS3
T5374 8050-8057 JJ denotes nuclear
T5375 8058-8071 NN denotes translocation
T5376 8071-8072 -COMMA- denotes ,
T5377 8073-8075 PRP denotes we
T5378 8076-8084 VB denotes measured
T5379 8085-8089 CC denotes both
T5380 8090-8105 NN denotes RPS3-importin-α
T5381 8106-8117 NN denotes association
T5382 8118-8121 CC denotes and
T5383 8122-8129 JJ denotes nuclear
T5384 8130-8134 NN denotes RPS3
T5385 8135-8140 IN denotes after
T5386 8141-8149 VB denotes reducing
T5387 8150-8154 NN denotes IκBα
T5388 8155-8165 NN denotes expression
T5389 8167-8175 VB denotes Compared
T5390 8176-8180 IN denotes with
T5391 8181-8192 JJ denotes nonspecific
T5392 8193-8198 NN denotes siRNA
T5393 8198-8199 -COMMA- denotes ,
T5394 8200-8205 NN denotes siRNA
T5395 8206-8215 NN denotes targeting
T5396 8216-8218 IN denotes of
T5397 8219-8223 NN denotes IκBα
T5398 8224-8234 RB denotes completely
T5399 8235-8243 VB denotes depleted
T5400 8244-8248 NN denotes IκBα
T5401 8249-8251 IN denotes in
T5402 8252-8258 NN denotes Jurkat
T5403 8259-8264 NN denotes cells
T5404 8265-8266 -LRB- denotes (
T5405 8266-8270 NN denotes Fig.
T5406 8271-8273 NN denotes 3c
T5407 8273-8274 -COMMA- denotes ,
T5408 8275-8280 NN denotes input
T5409 8280-8281 -RRB- denotes )
T5410 8283-8295 RB denotes Nevertheless
T5411 8295-8296 -COMMA- denotes ,
T5412 8297-8300 DT denotes the
T5413 8301-8316 NN denotes RPS3-importin-α
T5414 8317-8328 NN denotes association
T5415 8329-8332 VB denotes was
T5416 8333-8336 RB denotes not
T5417 8337-8346 JJ denotes augmented
T5418 8347-8348 -LRB- denotes (
T5419 8348-8352 NNP denotes Fig.
T5420 8353-8355 NN denotes 3c
T5421 8355-8356 -RRB- denotes )
T5422 8356-8357 -COMMA- denotes ,
T5423 8358-8361 CC denotes nor
T5424 8362-8365 VB denotes was
T5425 8366-8377 JJ denotes significant
T5426 8378-8385 JJ denotes nuclear
T5427 8386-8390 NN denotes RPS3
T5428 8391-8399 VB denotes detected
T5429 8400-8401 -LRB- denotes (
T5430 8401-8405 NNP denotes Fig.
T5431 8406-8408 NNP denotes 3d
T5432 8408-8409 -RRB- denotes )
T5433 8411-8419 RB denotes Moreover
T5434 8419-8420 -COMMA- denotes ,
T5435 8421-8426 NN denotes cells
T5436 8427-8434 VB denotes treated
T5437 8435-8439 IN denotes with
T5438 8440-8446 NN denotes sodium
T5439 8447-8458 NN denotes pervanadate
T5440 8459-8460 -LRB- denotes (
T5441 8460-8462 NN denotes Pv
T5442 8462-8463 -RRB- denotes )
T5443 8464-8466 TO denotes to
T5444 8467-8473 VB denotes induce
T5445 8474-8478 NN denotes IκBα
T5446 8479-8490 NN denotes degradation
T5447 8491-8498 IN denotes through
T5448 8499-8501 DT denotes an
T5449 8502-8517 JJ denotes IKK-independent
T5450 8518-8532 NN denotes mechanism25-27
T5451 8533-8536 VB denotes did
T5452 8537-8540 RB denotes not
T5453 8541-8545 VB denotes show
T5454 8546-8555 VB denotes increased
T5455 8556-8567 NN denotes association
T5456 8568-8575 IN denotes between
T5457 8576-8580 NN denotes RPS3
T5458 8581-8584 CC denotes and
T5459 8585-8595 NN denotes importin-α
T5460 8596-8597 -LRB- denotes (
T5461 8597-8601 NN denotes Fig.
T5462 8602-8604 NN denotes 3e
T5463 8605-8608 CC denotes and
T5464 8609-8622 NNP denotes Supplementary
T5465 8623-8627 NNP denotes Fig.
T5466 8628-8630 NN denotes 3b
T5467 8630-8631 -RRB- denotes )
T5468 8632-8634 CC denotes or
T5469 8635-8642 JJ denotes nuclear
T5470 8643-8655 NN denotes accumulation
T5471 8656-8658 IN denotes of
T5472 8659-8663 NN denotes RPS3
T5473 8663-8664 -COMMA- denotes ,
T5474 8665-8672 IN denotes despite
T5475 8673-8681 JJ denotes complete
T5476 8682-8686 NN denotes IκBα
T5477 8687-8698 NN denotes degradation
T5478 8699-8700 -LRB- denotes (
T5479 8700-8713 NNP denotes Supplementary
T5480 8714-8718 NNP denotes Fig.
T5481 8719-8721 NN denotes 3c
T5482 8721-8722 -RRB- denotes )
T5483 8724-8726 PRP denotes We
T5484 8727-8734 RB denotes further
T5485 8735-8743 VB denotes examined
T5486 8744-8751 IN denotes whether
T5487 8752-8753 DT denotes a
T5488 8754-8764 JJ denotes subsequent
T5489 8765-8770 NN denotes NF-κB
T5490 8771-8781 NN denotes activation
T5491 8782-8788 NN denotes signal
T5492 8789-8802 RB denotes independently
T5493 8803-8811 VB denotes promotes
T5494 8812-8815 DT denotes the
T5495 8816-8826 JJ denotes importin-α
T5496 8827-8838 NN denotes association
T5497 8839-8842 CC denotes and
T5498 8843-8850 JJ denotes nuclear
T5499 8851-8860 NN denotes transport
T5500 8861-8863 IN denotes of
T5501 8864-8868 NN denotes RPS3
T5502 8869-8874 IN denotes after
T5503 8875-8879 NN denotes IκBα
T5504 8880-8891 NN denotes degradation
T5505 8893-8895 PRP denotes We
T5506 8896-8901 VB denotes found
T5507 8902-8906 IN denotes that
T5508 8907-8910 NN denotes TNF
T5509 8911-8922 NN denotes stimulation
T5510 8923-8932 VB denotes following
T5511 8933-8935 NN denotes Pv
T5512 8936-8945 NN denotes treatment
T5513 8946-8949 VB denotes was
T5514 8950-8958 VB denotes required
T5515 8959-8962 IN denotes for
T5516 8963-8966 DT denotes the
T5517 8967-8982 NN denotes RPS3-importin-α
T5518 8983-8994 NN denotes association
T5519 8994-8995 -COMMA- denotes ,
T5520 8996-9006 JJ denotes comparable
T5521 9007-9009 TO denotes to
T5522 9010-9013 NN denotes TNF
T5523 9014-9025 NN denotes stimulation
T5524 9026-9031 RB denotes alone
T5525 9032-9033 -LRB- denotes (
T5526 9033-9037 NNP denotes Fig.
T5527 9038-9040 NN denotes 3e
T5528 9040-9041 -RRB- denotes )
T5529 9043-9047 RB denotes Thus
T5530 9047-9048 -COMMA- denotes ,
T5531 9049-9053 NN denotes IκBα
T5532 9054-9069 NN denotes phosphorylation
T5533 9070-9073 CC denotes and
T5534 9074-9085 NN denotes degradation
T5535 9086-9092 PRP denotes itself
T5536 9093-9095 VB denotes is
T5537 9096-9104 VB denotes required
T5538 9105-9108 CC denotes but
T5539 9109-9112 RB denotes not
T5540 9113-9123 JJ denotes sufficient
T5541 9124-9126 TO denotes to
T5542 9127-9132 VB denotes cause
T5543 9133-9137 NN denotes RPS3
T5544 9138-9149 NN denotes association
T5545 9150-9154 IN denotes with
T5546 9155-9165 NN denotes importin-α
T5547 9166-9174 VB denotes followed
T5548 9175-9177 IN denotes by
T5549 9178-9185 JJ denotes nuclear
T5550 9186-9199 NN denotes translocation
T5551 9201-9207 RB denotes Rather
T5552 9207-9208 -COMMA- denotes ,
T5553 9209-9211 DT denotes an
T5554 9212-9222 JJ denotes additional
T5555 9223-9229 NN denotes signal
T5556 9229-9230 -COMMA- denotes ,
T5557 9231-9242 RB denotes potentially
T5558 9243-9247 NN denotes IKKβ
T5559 9248-9263 NN denotes phosphorylation
T5560 9264-9266 IN denotes of
T5561 9267-9271 NN denotes RPS3
T5562 9271-9272 -COMMA- denotes ,
T5563 9273-9275 VB denotes is
T5564 9276-9284 VB denotes required
T7159 9287-9291 NN denotes IKKβ
T7160 9292-9306 VB denotes phosphorylates
T7161 9307-9311 NN denotes RPS3
T7162 9312-9314 IN denotes at
T7163 9315-9321 NN denotes serine
T7164 9322-9325 CD denotes 209
T7165 9326-9334 IN denotes Although
T7166 9335-9345 RB denotes originally
T7167 9346-9353 VB denotes defined
T7168 9354-9356 IN denotes as
T7169 9357-9360 DT denotes the
T7170 9361-9367 NN denotes kinase
T7171 9368-9372 WDT denotes that
T7172 9373-9387 VB denotes phosphorylates
T7173 9388-9393 NN denotes IκB19
T7174 9393-9394 -COMMA- denotes ,
T7175 9395-9399 NN denotes IKKβ
T7176 9400-9404 RB denotes also
T7177 9405-9419 VB denotes phosphorylates
T7178 9420-9429 JJ denotes unrelated
T7179 9430-9440 NN denotes substrates
T7180 9441-9450 VB denotes including
T7181 9451-9458 JJ denotes 14-3-3β
T7182 9459-9462 CC denotes and
T7183 9463-9468 NN denotes Bcl10
T7184 9468-9469 -COMMA- denotes ,
T7185 9470-9475 WDT denotes which
T7186 9476-9480 VB denotes lack
T7187 9481-9484 DT denotes the
T7188 9485-9488 NN denotes IKK
T7189 9489-9498 NN denotes consensus
T7190 9499-9504 NN denotes motif
T7191 9505-9506 -LRB- denotes (
T7192 9506-9516 NN denotes DpSGYXpS/T
T7193 9516-9517 -RRB- denotes )
T7194 9517-9519 CD denotes 28
T7195 9521-9523 PRP denotes We
T7196 9524-9533 RB denotes therefore
T7197 9534-9546 VB denotes hypothesized
T7198 9547-9551 IN denotes that
T7199 9552-9556 NN denotes IKKβ
T7200 9557-9562 MD denotes could
T7201 9563-9571 RB denotes directly
T7202 9572-9585 VB denotes phosphorylate
T7203 9586-9590 NN denotes RPS3
T7204 9592-9594 IN denotes By
T7205 9595-9597 FW denotes in
T7206 9598-9603 FW denotes vitro
T7207 9604-9610 NN denotes kinase
T7208 9611-9617 NN denotes assays
T7209 9618-9623 VB denotes using
T7210 9624-9635 JJ denotes recombinant
T7211 9636-9639 NN denotes IKK
T7212 9640-9643 CC denotes and
T7213 9644-9648 NN denotes RPS3
T7214 9649-9657 NN denotes proteins
T7215 9657-9658 -COMMA- denotes ,
T7216 9659-9661 PRP denotes we
T7217 9662-9670 VB denotes observed
T7218 9671-9677 JJ denotes strong
T7219 9678-9691 NN denotes incorporation
T7220 9692-9694 IN denotes of
T7221 9695-9698 NN denotes 32P
T7222 9699-9701 IN denotes in
T7223 9702-9719 NN denotes autophosphorylatd
T7224 9720-9724 NN denotes IKKα
T7225 9725-9728 CC denotes and
T7226 9729-9733 NN denotes IKKβ
T7227 9734-9735 -LRB- denotes (
T7228 9735-9739 NNP denotes Fig.
T7229 9740-9742 NN denotes 4a
T7230 9742-9743 -COMMA- denotes ,
T7231 9744-9749 NN denotes lanes
T7232 9750-9753 CD denotes 2-7
T7233 9753-9754 -RRB- denotes )
T7234 9755-9757 RB denotes as
T7235 9758-9762 RB denotes well
T7236 9763-9765 IN denotes as
T7237 9766-9779 VB denotes phosporylated
T7238 9780-9788 NN denotes GST-IκBα
T7239 9789-9790 -LRB- denotes (
T7240 9790-9794 CD denotes 1-54
T7241 9794-9795 -RRB- denotes )
T7242 9796-9797 -LRB- denotes (
T7243 9797-9810 NNP denotes Supplementary
T7244 9811-9815 NNP denotes Fig.
T7245 9816-9817 CD denotes 4
T7246 9817-9818 -RRB- denotes )
T7247 9818-9819 -COMMA- denotes ,
T7248 9820-9823 CC denotes but
T7249 9824-9827 RB denotes not
T7250 9828-9831 DT denotes the
T7251 9832-9835 NN denotes GST
T7252 9836-9843 NN denotes protein
T7253 9844-9849 RB denotes alone
T7254 9850-9851 -LRB- denotes (
T7255 9851-9855 NNP denotes Fig.
T7256 9856-9858 NN denotes 4a
T7257 9858-9859 -COMMA- denotes ,
T7258 9860-9865 NN denotes lanes
T7259 9866-9867 CD denotes 3
T7260 9868-9871 CC denotes and
T7261 9872-9873 CD denotes 6
T7262 9873-9874 -RRB- denotes )
T7263 9874-9875 -COMMA- denotes ,
T7264 9876-9880 WRB denotes when
T7265 9881-9887 CC denotes either
T7266 9888-9892 NN denotes IKKα
T7267 9893-9895 CC denotes or
T7268 9896-9900 NN denotes IKKβ
T7269 9901-9904 VB denotes was
T7270 9905-9909 VB denotes used
T7271 9911-9913 PRP denotes We
T7272 9914-9924 VB denotes discovered
T7273 9925-9929 IN denotes that
T7274 9930-9938 NN denotes GST-RPS3
T7275 9939-9944 MD denotes could
T7276 9945-9947 VB denotes be
T7277 9948-9962 VB denotes phosphorylated
T7278 9963-9965 IN denotes by
T7279 9966-9970 NN denotes IKKβ
T7280 9970-9971 -COMMA- denotes ,
T7281 9972-9975 CC denotes but
T7282 9976-9979 RB denotes not
T7283 9980-9984 NN denotes IKKα
T7284 9984-9985 -COMMA- denotes ,
T7285 9986-9988 FW denotes in
T7286 9989-9994 FW denotes vitro
T7287 9995-9996 -LRB- denotes (
T7288 9996-10000 FW denotes Fig.
T7289 10001-10003 NN denotes 4a
T7290 10003-10004 -COMMA- denotes ,
T7291 10005-10012 NN denotes compare
T7292 10013-10018 NN denotes lanes
T7293 10019-10020 CD denotes 4
T7294 10021-10024 CC denotes and
T7295 10025-10026 CD denotes 7
T7296 10026-10027 -RRB- denotes )
T7297 10029-10031 TO denotes To
T7298 10032-10040 VB denotes identify
T7299 10041-10044 DT denotes the
T7300 10045-10049 NN denotes RPS3
T7301 10050-10055 JJ denotes amino
T7302 10056-10060 NN denotes acid
T7303 10061-10068 NN denotes residue
T7304 10068-10069 -LRB- denotes (
T7305 10069-10070 NN denotes s
T7306 10070-10071 -RRB- denotes )
T7307 10072-10086 VB denotes phosphorylated
T7308 10087-10089 IN denotes by
T7309 10090-10094 NN denotes IKKβ
T7310 10094-10095 -COMMA- denotes ,
T7311 10096-10098 PRP denotes we
T7312 10099-10108 VB denotes performed
T7313 10109-10115 JJ denotes liquid
T7314 10116-10137 JJ denotes chromatography-tandem
T7315 10138-10142 NN denotes mass
T7316 10143-10155 NN denotes spectrometry
T7317 10156-10164 NN denotes analyses
T7318 10165-10170 VB denotes using
T7319 10171-10173 FW denotes in
T7320 10174-10179 FW denotes vitro
T7321 10180-10194 VB denotes phosphorylated
T7322 10195-10199 NN denotes RPS3
T7323 10201-10204 DT denotes The
T7324 10205-10212 NN denotes results
T7325 10213-10222 VB denotes indicated
T7326 10223-10227 IN denotes that
T7327 10228-10232 NN denotes IKKβ
T7328 10233-10247 VB denotes phosphorylated
T7329 10248-10252 NN denotes S209
T7330 10252-10253 -COMMA- denotes ,
T7331 10254-10261 JJ denotes located
T7332 10262-10264 IN denotes in
T7333 10265-10268 DT denotes the
T7334 10269-10273 NN denotes RPS3
T7335 10274-10284 NN denotes C-terminus
T7336 10285-10286 -LRB- denotes (
T7337 10286-10290 NN denotes Fig.
T7338 10291-10293 NN denotes 4b
T7339 10293-10294 -RRB- denotes )
T7340 10296-10300 NN denotes RPS3
T7341 10301-10306 JJ denotes amino
T7342 10307-10311 NN denotes acid
T7343 10312-10320 NN denotes sequence
T7344 10321-10330 NN denotes alignment
T7345 10331-10339 VB denotes revealed
T7346 10340-10344 IN denotes that
T7347 10345-10349 NN denotes S209
T7348 10350-10352 VB denotes is
T7349 10353-10362 VB denotes conserved
T7350 10363-10365 IN denotes in
T7351 10366-10370 JJ denotes many
T7352 10371-10378 NN denotes species
T7353 10379-10389 IN denotes throughout
T7354 10390-10399 NN denotes phylogeny
T7355 10400-10404 IN denotes with
T7356 10405-10408 DT denotes the
T7357 10409-10418 NN denotes exception
T7358 10419-10421 IN denotes of
T7359 10422-10436 NN denotes Caenorhabditis
T7360 10437-10444 NN denotes elegans
T7361 10445-10448 CC denotes and
T7362 10449-10468 FW denotes Schizosaccharomyces
T7363 10469-10474 FW denotes pombe
T7364 10474-10475 -COMMA- denotes ,
T7365 10476-10479 CD denotes two
T7366 10480-10489 NN denotes organisms
T7367 10490-10494 WDT denotes that
T7368 10495-10497 VB denotes do
T7369 10498-10501 RB denotes not
T7370 10502-10509 VB denotes possess
T7371 10510-10513 DT denotes the
T7372 10514-10519 NN denotes NF-κB
T7373 10520-10526 NN denotes signal
T7374 10527-10534 NN denotes pathway
T7375 10535-10536 -LRB- denotes (
T7376 10536-10549 NNP denotes Supplementary
T7377 10550-10554 NNP denotes Fig.
T7378 10555-10556 CD denotes 5
T7379 10556-10557 -RRB- denotes )
T7380 10559-10561 TO denotes To
T7381 10562-10568 VB denotes verify
T7382 10569-10582 RB denotes biochemically
T7383 10583-10587 IN denotes that
T7384 10588-10592 NN denotes S209
T7385 10593-10595 VB denotes is
T7386 10596-10598 DT denotes an
T7387 10599-10603 NN denotes IKKβ
T7388 10604-10613 NN denotes substrate
T7389 10613-10614 -COMMA- denotes ,
T7390 10615-10617 PRP denotes we
T7391 10618-10627 VB denotes performed
T7392 10628-10640 JJ denotes 32P-labeling
T7393 10641-10643 FW denotes in
T7394 10644-10649 FW denotes vitro
T7395 10650-10656 NN denotes kinase
T7396 10657-10663 NN denotes assays
T7397 10664-10668 IN denotes with
T7398 10669-10680 JJ denotes recombinant
T7399 10681-10690 JJ denotes wild-type
T7400 10691-10693 CC denotes or
T7401 10694-10699 NN denotes S209A
T7402 10700-10706 JJ denotes mutant
T7403 10707-10711 NN denotes RPS3
T7404 10712-10720 NN denotes proteins
T7405 10722-10730 VB denotes Compared
T7406 10731-10735 IN denotes with
T7407 10736-10739 DT denotes the
T7408 10740-10749 JJ denotes wild-type
T7409 10750-10757 NN denotes protein
T7410 10757-10758 -COMMA- denotes ,
T7411 10759-10762 DT denotes the
T7412 10763-10768 NN denotes S209A
T7413 10769-10777 NN denotes mutation
T7414 10778-10785 VB denotes reduced
T7415 10786-10799 JJ denotes IKKβ–mediated
T7416 10800-10804 NN denotes RPS3
T7417 10805-10820 NN denotes phosphorylation
T7418 10821-10822 -LRB- denotes (
T7419 10822-10826 NN denotes Fig.
T7420 10827-10829 NN denotes 4c
T7421 10829-10830 -RRB- denotes )
T7422 10832-10837 EX denotes There
T7423 10838-10843 MD denotes might
T7424 10844-10846 VB denotes be
T7425 10847-10858 JJ denotes alternative
T7426 10859-10874 NN denotes phosphorylation
T7427 10875-10879 NN denotes site
T7428 10879-10880 -LRB- denotes (
T7429 10880-10881 NN denotes s
T7430 10881-10882 -RRB- denotes )
T7431 10883-10888 IN denotes under
T7432 10889-10894 DT denotes these
T7433 10895-10905 NN denotes conditions
T7434 10906-10911 VB denotes given
T7435 10912-10918 JJ denotes modest
T7436 10919-10927 JJ denotes residual
T7437 10928-10942 VB denotes phosphorylated
T7438 10943-10947 NN denotes RPS3
T7439 10948-10949 -LRB- denotes (
T7440 10949-10953 NN denotes Fig.
T7441 10954-10956 NN denotes 4c
T7442 10956-10957 -RRB- denotes )
T7443 10959-10963 NN denotes RPS3
T7444 10964-10968 NN denotes S209
T7445 10969-10973 VB denotes does
T7446 10974-10977 RB denotes not
T7447 10978-10982 VB denotes fall
T7448 10983-10989 IN denotes within
T7449 10990-10991 DT denotes a
T7450 10992-11004 JJ denotes conventional
T7451 11005-11008 NN denotes IKK
T7452 11009-11020 NN denotes recognition
T7453 11021-11026 NN denotes motif
T7454 11026-11027 -COMMA- denotes ,
T7455 11028-11031 CC denotes but
T7456 11032-11038 RB denotes rather
T7457 11039-11046 VB denotes resides
T7458 11047-11049 IN denotes in
T7459 11050-11051 DT denotes a
T7460 11052-11060 NN denotes sequence
T7461 11061-11066 NN denotes motif
T7462 11067-11068 -LRB- denotes (
T7463 11068-11078 NN denotes XXXpS/TXXE
T7464 11078-11079 -RRB- denotes )
T7465 11079-11080 -COMMA- denotes ,
T7466 11081-11092 RB denotes potentially
T7467 11093-11103 VB denotes recognized
T7468 11104-11106 IN denotes by
T7469 11107-11113 NN denotes casein
T7470 11114-11120 NN denotes kinase
T7471 11121-11123 CD denotes II
T7472 11124-11125 -LRB- denotes (
T7473 11125-11128 NN denotes CK2
T7474 11128-11129 -RRB- denotes )
T7475 11131-11139 IN denotes Although
T7476 11140-11144 NN denotes IKKβ
T7477 11145-11151 NN denotes kinase
T7478 11152-11155 MD denotes can
T7479 11156-11163 VB denotes display
T7480 11164-11165 DT denotes a
T7481 11166-11174 JJ denotes CK2-like
T7482 11175-11190 NN denotes phosphorylation
T7483 11191-11204 NN denotes specificity29
T7484 11204-11205 -COMMA- denotes ,
T7485 11206-11208 DT denotes no
T7486 11209-11212 NN denotes CK2
T7487 11213-11220 NN denotes protein
T7488 11221-11224 VB denotes was
T7489 11225-11235 JJ denotes detectable
T7490 11236-11238 IN denotes in
T7491 11239-11242 PRP-DOLLAR- denotes our
T7492 11243-11254 JJ denotes recombinant
T7493 11255-11258 NN denotes IKK
T7494 11259-11267 NN denotes proteins
T7495 11268-11269 -LRB- denotes (
T7496 11269-11282 NNP denotes Supplementary
T7497 11283-11287 NNP denotes Fig.
T7498 11288-11289 CD denotes 6
T7499 11289-11290 -RRB- denotes )
T7500 11292-11296 RB denotes Thus
T7501 11296-11297 -COMMA- denotes ,
T7502 11298-11302 NN denotes RPS3
T7503 11303-11307 NN denotes S209
T7504 11308-11323 NN denotes phosphorylation
T7505 11324-11327 VB denotes was
T7506 11328-11331 JJ denotes due
T7507 11332-11334 TO denotes to
T7508 11335-11338 DT denotes the
T7509 11339-11348 JJ denotes alternate
T7510 11349-11360 NN denotes specificity
T7511 11361-11363 IN denotes of
T7512 11364-11367 DT denotes the
T7513 11368-11372 NN denotes IKKβ
T7514 11373-11379 NN denotes kinase
T7515 11380-11386 RB denotes rather
T7516 11387-11391 IN denotes than
T7517 11392-11395 DT denotes any
T7518 11396-11401 NN denotes trace
T7519 11402-11408 NN denotes amount
T7520 11409-11411 IN denotes of
T7521 11412-11415 NN denotes CK2
T7522 11416-11421 VB denotes bound
T7523 11422-11424 TO denotes to
T7524 11425-11429 NN denotes IKKs
T7525 11431-11433 TO denotes To
T7526 11434-11443 VB denotes determine
T7527 11444-11451 IN denotes whether
T7528 11452-11456 NN denotes S209
T7529 11457-11459 VB denotes is
T7530 11460-11463 DT denotes the
T7531 11464-11472 JJ denotes critical
T7532 11473-11477 NN denotes site
T7533 11478-11480 IN denotes at
T7534 11481-11486 WDT denotes which
T7535 11487-11491 NN denotes IKKβ
T7536 11492-11506 VB denotes phosphorylates
T7537 11507-11511 NN denotes RPS3
T7538 11512-11514 IN denotes in
T7539 11515-11521 VB denotes living
T7540 11522-11527 NN denotes cells
T7541 11527-11528 -COMMA- denotes ,
T7542 11529-11531 PRP denotes we
T7543 11532-11543 VB denotes transfected
T7544 11544-11547 DT denotes the
T7545 11548-11557 JJ denotes wild-type
T7546 11558-11560 CC denotes or
T7547 11561-11566 NN denotes S209A
T7548 11567-11573 JJ denotes mutant
T7549 11574-11583 NN denotes Flag-RPS3
T7550 11584-11589 RB denotes alone
T7551 11589-11590 -COMMA- denotes ,
T7552 11591-11593 CC denotes or
T7553 11594-11602 RB denotes together
T7554 11603-11607 IN denotes with
T7555 11608-11612 NN denotes IKKβ
T7556 11613-11617 IN denotes into
T7557 11618-11623 NN denotes cells
T7558 11625-11631 RB denotes Indeed
T7559 11631-11632 -COMMA- denotes ,
T7560 11633-11635 PRP denotes we
T7561 11636-11644 VB denotes observed
T7562 11645-11649 IN denotes that
T7563 11650-11664 VB denotes overexpressing
T7564 11665-11669 NN denotes IKKβ
T7565 11670-11678 VB denotes enhanced
T7566 11679-11688 NN denotes Flag-RPS3
T7567 11689-11704 NN denotes phosphorylation
T7568 11704-11705 -COMMA- denotes ,
T7569 11706-11709 CC denotes but
T7570 11710-11725 NN denotes phosphorylation
T7571 11726-11729 VB denotes was
T7572 11730-11741 RB denotes effectively
T7573 11742-11752 VB denotes eliminated
T7574 11753-11755 IN denotes by
T7575 11756-11763 NN denotes alanine
T7576 11764-11776 NN denotes substitution
T7577 11777-11787 VB denotes indicating
T7578 11788-11792 IN denotes that
T7579 11793-11797 NN denotes S209
T7580 11798-11800 VB denotes is
T7581 11801-11804 DT denotes the
T7582 11805-11816 JJ denotes predominant
T7583 11817-11823 NN denotes target
T7584 11824-11828 NN denotes site
T7585 11829-11832 IN denotes for
T7586 11833-11837 NN denotes IKKβ
T7587 11838-11853 NN denotes phosphorylation
T7588 11854-11855 -LRB- denotes (
T7589 11855-11859 NNP denotes Fig.
T7590 11860-11862 NN denotes 4d
T7591 11862-11863 -RRB- denotes )
T7592 11865-11867 PRP denotes We
T7593 11868-11872 RB denotes next
T7594 11873-11882 VB denotes generated
T7595 11883-11884 DT denotes a
T7596 11885-11897 NN denotes phospho-S209
T7597 11898-11902 NN denotes RPS3
T7598 11903-11911 NN denotes antibody
T7599 11912-11915 CC denotes and
T7600 11916-11925 VB denotes confirmed
T7601 11926-11930 IN denotes that
T7602 11931-11941 JJ denotes endogenous
T7603 11942-11946 NN denotes RPS3
T7604 11947-11950 VB denotes was
T7605 11951-11965 VB denotes phosphorylated
T7606 11966-11968 IN denotes at
T7607 11969-11973 NN denotes S209
T7608 11974-11976 IN denotes in
T7609 11977-11978 DT denotes a
T7610 11979-11993 JJ denotes time-dependent
T7611 11994-12000 NN denotes manner
T7612 12001-12005 IN denotes upon
T7613 12006-12009 NN denotes TNF
T7614 12010-12021 NN denotes stimulation
T7615 12022-12023 -LRB- denotes (
T7616 12023-12027 NN denotes Fig.
T7617 12028-12030 NN denotes 4e
T7618 12030-12031 -RRB- denotes )
T7619 12033-12037 RB denotes Thus
T7620 12037-12038 -COMMA- denotes ,
T7621 12039-12042 DT denotes the
T7622 12043-12047 NN denotes RPS3
T7623 12048-12058 JJ denotes C-terminal
T7624 12059-12063 NN denotes tail
T7625 12064-12075 RB denotes potentially
T7626 12076-12084 VB denotes contains
T7627 12085-12087 DT denotes an
T7628 12088-12097 JJ denotes important
T7629 12098-12108 JJ denotes regulatory
T7630 12109-12113 NN denotes site
T9178 12116-12131 NN denotes Phosphorylation
T9179 12132-12134 IN denotes of
T9180 12135-12139 NN denotes RPS3
T9181 12140-12143 CC denotes and
T9182 12144-12147 PRP-DOLLAR- denotes its
T9183 12148-12153 NN denotes NF-κB
T9184 12154-12162 NN denotes function
T9185 12163-12165 PRP denotes We
T9186 12166-12170 RB denotes next
T9187 12171-12179 VB denotes examined
T9188 12180-12187 IN denotes whether
T9189 12188-12192 NN denotes S209
T9190 12193-12208 NN denotes phosphorylation
T9191 12209-12214 VB denotes plays
T9192 12215-12216 DT denotes a
T9193 12217-12221 NN denotes role
T9194 12222-12224 IN denotes in
T9195 12225-12228 DT denotes the
T9196 12229-12236 JJ denotes nuclear
T9197 12237-12250 NN denotes translocation
T9198 12251-12253 IN denotes of
T9199 12254-12258 NN denotes RPS3
T9200 12259-12265 IN denotes during
T9201 12266-12271 NN denotes NF-κB
T9202 12272-12282 NN denotes activation
T9203 12284-12295 JJ denotes Subcellular
T9204 12296-12305 NN denotes fractions
T9205 12306-12310 IN denotes from
T9206 12311-12317 CC denotes either
T9207 12318-12327 JJ denotes wild-type
T9208 12328-12330 CC denotes or
T9209 12331-12336 NN denotes S209A
T9210 12337-12343 JJ denotes mutant
T9211 12344-12360 JJ denotes RPS3-transfected
T9212 12361-12366 NN denotes cells
T9213 12367-12371 VB denotes were
T9214 12372-12380 VB denotes prepared
T9215 12381-12384 CC denotes and
T9216 12385-12392 VB denotes blotted
T9217 12393-12396 IN denotes for
T9218 12397-12407 NN denotes heat-shock
T9219 12408-12415 NN denotes protein
T9220 12416-12418 CD denotes 90
T9221 12419-12420 -LRB- denotes (
T9222 12420-12425 NN denotes hsp90
T9223 12425-12426 -RRB- denotes )
T9224 12426-12427 -COMMA- denotes ,
T9225 12428-12429 DT denotes a
T9226 12430-12441 JJ denotes cytoplasmic
T9227 12442-12449 NN denotes protein
T9228 12449-12450 -COMMA- denotes ,
T9229 12451-12454 CC denotes and
T9230 12455-12459 NN denotes poly
T9231 12460-12461 -LRB- denotes (
T9232 12461-12471 NN denotes ADP-ribose
T9233 12471-12472 -RRB- denotes )
T9234 12473-12483 NN denotes polymerase
T9235 12484-12485 -LRB- denotes (
T9236 12485-12489 NN denotes PARP
T9237 12489-12490 -RRB- denotes )
T9238 12490-12491 -COMMA- denotes ,
T9239 12492-12493 DT denotes a
T9240 12494-12501 JJ denotes nuclear
T9241 12502-12509 NN denotes protein
T9242 12509-12510 -COMMA- denotes ,
T9243 12511-12521 VB denotes confirming
T9244 12522-12523 DT denotes a
T9245 12524-12529 JJ denotes clean
T9246 12530-12540 NN denotes separation
T9247 12541-12542 -LRB- denotes (
T9248 12542-12546 NN denotes Fig.
T9249 12547-12549 NN denotes 5a
T9250 12549-12550 -RRB- denotes )
T9251 12552-12554 IN denotes As
T9252 12555-12563 VB denotes expected
T9253 12563-12564 -COMMA- denotes ,
T9254 12565-12570 NN denotes PMA+I
T9255 12571-12582 NN denotes stimulation
T9256 12583-12592 VB denotes triggered
T9257 12593-12602 JJ denotes wild-type
T9258 12603-12612 NN denotes Flag-RPS3
T9259 12613-12620 JJ denotes nuclear
T9260 12621-12634 NN denotes translocation
T9261 12635-12636 -LRB- denotes (
T9262 12636-12640 NN denotes Fig.
T9263 12641-12643 NN denotes 5a
T9264 12643-12644 -RRB- denotes )
T9265 12646-12653 RB denotes However
T9266 12653-12654 -COMMA- denotes ,
T9267 12655-12659 NN denotes RPS3
T9268 12660-12661 -LRB- denotes (
T9269 12661-12666 NN denotes S209A
T9270 12666-12667 -RRB- denotes )
T9271 12668-12675 JJ denotes nuclear
T9272 12676-12689 NN denotes translocation
T9273 12690-12693 VB denotes was
T9274 12694-12704 VB denotes attenuated
T9275 12705-12706 -LRB- denotes (
T9276 12706-12710 NNP denotes Fig.
T9277 12711-12713 NN denotes 5a
T9278 12713-12714 -RRB- denotes )
T9279 12716-12718 PRP denotes We
T9280 12719-12723 RB denotes also
T9281 12724-12730 VB denotes tested
T9282 12731-12734 DT denotes the
T9283 12735-12741 NN denotes impact
T9284 12742-12744 IN denotes of
T9285 12745-12755 VB denotes activating
T9286 12756-12761 NN denotes NF-κB
T9287 12762-12764 IN denotes by
T9288 12765-12779 VB denotes overexpressing
T9289 12780-12784 NN denotes IKKβ
T9290 12785-12787 IN denotes on
T9291 12788-12792 NN denotes RPS3
T9292 12793-12800 JJ denotes nuclear
T9293 12801-12814 NN denotes translocation
T9294 12816-12820 NN denotes IKKβ
T9295 12821-12835 NN denotes overexpression
T9296 12836-12845 VB denotes activated
T9297 12846-12851 NN denotes NF-κB
T9298 12852-12860 VB denotes measured
T9299 12861-12863 IN denotes by
T9300 12864-12874 NN denotes luciferase
T9301 12875-12881 NN denotes assays
T9302 12882-12883 -LRB- denotes (
T9303 12883-12896 NNP denotes Supplementary
T9304 12897-12901 NNP denotes Fig.
T9305 12902-12903 CD denotes 7
T9306 12903-12904 -RRB- denotes )
T9307 12904-12905 -COMMA- denotes ,
T9308 12906-12909 CC denotes and
T9309 12910-12914 RB denotes also
T9310 12915-12922 VB denotes induced
T9311 12923-12926 DT denotes the
T9312 12927-12934 JJ denotes nuclear
T9313 12935-12948 NN denotes translocation
T9314 12949-12951 IN denotes of
T9315 12952-12961 JJ denotes wild-type
T9316 12961-12962 -COMMA- denotes ,
T9317 12963-12966 CC denotes but
T9318 12967-12970 RB denotes not
T9319 12971-12976 NN denotes S209A
T9320 12976-12977 -COMMA- denotes ,
T9321 12978-12982 NN denotes RPS3
T9322 12983-12984 -LRB- denotes (
T9323 12984-12988 NN denotes Fig.
T9324 12989-12991 NN denotes 5b
T9325 12991-12992 -RRB- denotes )
T9326 12994-12999 DT denotes These
T9327 13000-13004 NN denotes data
T9328 13005-13012 VB denotes suggest
T9329 13013-13017 IN denotes that
T9330 13018-13022 NN denotes S209
T9331 13023-13038 NN denotes phosphorylation
T9332 13039-13041 VB denotes is
T9333 13042-13050 JJ denotes critical
T9334 13051-13054 IN denotes for
T9335 13055-13058 DT denotes the
T9336 13059-13064 NN denotes NF-κB
T9337 13065-13083 JJ denotes activation-induced
T9338 13084-13088 NN denotes RPS3
T9339 13089-13096 JJ denotes nuclear
T9340 13097-13110 NN denotes translocation
T9341 13112-13114 TO denotes To
T9342 13115-13122 VB denotes examine
T9343 13123-13126 DT denotes the
T9344 13127-13131 NN denotes role
T9345 13132-13134 IN denotes of
T9346 13135-13139 NN denotes S209
T9347 13140-13155 NN denotes phosphorylation
T9348 13156-13158 IN denotes of
T9349 13159-13163 NN denotes RPS3
T9350 13164-13166 TO denotes to
T9351 13167-13170 PRP-DOLLAR- denotes its
T9352 13171-13176 NN denotes NF-κB
T9353 13177-13186 NN denotes function6
T9354 13186-13187 -COMMA- denotes ,
T9355 13188-13189 CD denotes 7
T9356 13189-13190 -COMMA- denotes ,
T9357 13191-13193 CD denotes 30
T9358 13193-13194 -COMMA- denotes ,
T9359 13195-13197 PRP denotes we
T9360 13198-13206 VB denotes silenced
T9361 13207-13217 JJ denotes endogenous
T9362 13218-13222 NN denotes RPS3
T9363 13223-13233 NN denotes expression
T9364 13234-13239 VB denotes using
T9365 13240-13242 DT denotes an
T9366 13243-13248 NN denotes siRNA
T9367 13249-13253 WDT denotes that
T9368 13254-13261 VB denotes targets
T9369 13262-13265 DT denotes the
T9370 13266-13268 CD denotes 3′
T9371 13269-13281 JJ denotes untranslated
T9372 13282-13288 NN denotes region
T9373 13289-13290 -LRB- denotes (
T9374 13290-13292 CD denotes 3′
T9375 13293-13296 NN denotes UTR
T9376 13296-13297 -RRB- denotes )
T9377 13298-13300 IN denotes of
T9378 13301-13305 NN denotes RPS3
T9379 13306-13310 NN denotes mRNA
T9380 13310-13311 -COMMA- denotes ,
T9381 13312-13320 VB denotes followed
T9382 13321-13323 IN denotes by
T9383 13324-13339 NN denotes complementation
T9384 13340-13344 IN denotes with
T9385 13345-13351 CC denotes either
T9386 13352-13361 JJ denotes wild-type
T9387 13362-13364 CC denotes or
T9388 13365-13370 NN denotes S209A
T9389 13371-13377 JJ denotes mutant
T9390 13378-13382 NN denotes RPS3
T9391 13383-13386 IN denotes via
T9392 13387-13399 NN denotes transfection
T9393 13401-13403 IN denotes As
T9394 13404-13412 VB denotes expected
T9395 13412-13413 -COMMA- denotes ,
T9396 13414-13418 NN denotes RPS3
T9397 13419-13424 NN denotes siRNA
T9398 13425-13433 RB denotes severely
T9399 13434-13441 VB denotes reduced
T9400 13442-13452 JJ denotes endogenous
T9401 13453-13457 NN denotes RPS3
T9402 13458-13467 NN denotes abundance
T9403 13468-13476 VB denotes compared
T9404 13477-13479 TO denotes to
T9405 13480-13482 NN denotes NS
T9406 13483-13488 NN denotes siRNA
T9407 13488-13489 -COMMA- denotes ,
T9408 13490-13493 CC denotes but
T9409 13494-13497 VB denotes did
T9410 13498-13501 RB denotes not
T9411 13502-13508 VB denotes affect
T9412 13509-13512 DT denotes the
T9413 13513-13519 JJ denotes robust
T9414 13520-13530 NN denotes expression
T9415 13531-13533 IN denotes of
T9416 13534-13545 JJ denotes Flag-tagged
T9417 13546-13550 NN denotes RPS3
T9418 13551-13555 IN denotes from
T9419 13556-13557 DT denotes a
T9420 13558-13569 VB denotes transfected
T9421 13570-13579 NN denotes construct
T9422 13580-13587 VB denotes lacking
T9423 13588-13591 DT denotes the
T9424 13592-13594 NN denotes 3′
T9425 13595-13598 NN denotes UTR
T9426 13599-13600 -LRB- denotes (
T9427 13600-13604 NN denotes Fig.
T9428 13605-13607 NN denotes 5c
T9429 13607-13608 -RRB- denotes )
T9430 13610-13612 PRP denotes We
T9431 13613-13617 RB denotes also
T9432 13618-13623 VB denotes found
T9433 13624-13628 IN denotes that
T9434 13629-13633 NN denotes RPS3
T9435 13634-13643 NN denotes knockdown
T9436 13644-13651 VB denotes reduced
T9437 13652-13663 JJ denotes TNF-induced
T9438 13664-13674 NN denotes expression
T9439 13675-13677 IN denotes of
T9440 13678-13680 DT denotes an
T9441 13681-13683 NN denotes Ig
T9442 13684-13693 JJ denotes κB-driven
T9443 13694-13704 NN denotes luciferase
T9444 13705-13715 NN denotes construct6
T9445 13716-13717 -LRB- denotes (
T9446 13717-13721 NNP denotes Fig.
T9447 13722-13724 NN denotes 5d
T9448 13724-13725 -RRB- denotes )
T9449 13727-13730 DT denotes The
T9450 13731-13739 JJ denotes impaired
T9451 13740-13750 NN denotes luciferase
T9452 13751-13757 NN denotes signal
T9453 13758-13764 VB denotes caused
T9454 13765-13767 IN denotes by
T9455 13768-13772 NN denotes RPS3
T9456 13773-13783 NN denotes deficiency
T9457 13784-13787 VB denotes was
T9458 13788-13798 RB denotes completely
T9459 13799-13807 VB denotes restored
T9460 13808-13810 IN denotes by
T9461 13811-13823 VB denotes transfecting
T9462 13824-13833 JJ denotes wild-type
T9463 13833-13834 -COMMA- denotes ,
T9464 13835-13838 CC denotes but
T9465 13839-13842 RB denotes not
T9466 13843-13845 IN denotes by
T9467 13846-13851 NN denotes S209A
T9468 13852-13856 NN denotes RPS3
T9469 13857-13858 -LRB- denotes (
T9470 13858-13862 NNP denotes Fig.
T9471 13863-13865 NN denotes 5d
T9472 13865-13866 -RRB- denotes )
T9473 13866-13867 -COMMA- denotes ,
T9474 13868-13875 IN denotes despite
T9475 13876-13886 JJ denotes equivalent
T9476 13887-13897 NN denotes expression
T9477 13898-13899 -LRB- denotes (
T9478 13899-13903 NN denotes Fig.
T9479 13904-13906 NN denotes 5c
T9480 13906-13907 -RRB- denotes )
T9481 13909-13917 RB denotes Moreover
T9482 13917-13918 -COMMA- denotes ,
T9483 13919-13922 DT denotes the
T9484 13923-13930 NN denotes failure
T9485 13931-13933 IN denotes of
T9486 13934-13939 NN denotes S209A
T9487 13940-13944 NN denotes RPS3
T9488 13945-13947 TO denotes to
T9489 13948-13955 VB denotes restore
T9490 13956-13966 NN denotes luciferase
T9491 13967-13975 NN denotes activity
T9492 13976-13979 VB denotes did
T9493 13980-13983 RB denotes not
T9494 13984-13990 VB denotes result
T9495 13991-13995 IN denotes from
T9496 13996-14005 JJ denotes defective
T9497 14006-14017 NN denotes translation
T9498 14018-14025 IN denotes because
T9499 14026-14029 DT denotes the
T9500 14030-14039 JJ denotes transient
T9501 14040-14054 NN denotes overexpression
T9502 14055-14057 IN denotes of
T9503 14058-14063 JJ denotes green
T9504 14064-14075 JJ denotes fluorescent
T9505 14076-14083 NN denotes protein
T9506 14084-14085 -LRB- denotes (
T9507 14085-14088 NN denotes GFP
T9508 14088-14089 -RRB- denotes )
T9509 14090-14093 VB denotes was
T9510 14094-14104 JJ denotes comparable
T9511 14105-14107 IN denotes in
T9512 14108-14113 NN denotes cells
T9513 14114-14126 VB denotes complemented
T9514 14127-14131 IN denotes with
T9515 14132-14141 JJ denotes wild-type
T9516 14142-14144 CC denotes or
T9517 14145-14150 NN denotes S029A
T9518 14151-14155 NN denotes RPS3
T9519 14156-14157 -LRB- denotes (
T9520 14157-14170 NNP denotes Supplementary
T9521 14171-14175 NNP denotes Fig.
T9522 14176-14177 CD denotes 8
T9523 14177-14178 -RRB- denotes )
T9524 14180-14185 VB denotes Taken
T9525 14186-14194 RB denotes together
T9526 14194-14195 -COMMA- denotes ,
T9527 14196-14201 DT denotes these
T9528 14202-14206 NN denotes data
T9529 14207-14214 VB denotes suggest
T9530 14215-14219 IN denotes that
T9531 14220-14224 NN denotes RPS3
T9532 14225-14229 NN denotes S209
T9533 14230-14245 NN denotes phosphorylation
T9534 14246-14248 VB denotes is
T9535 14249-14257 JJ denotes critical
T9536 14258-14261 IN denotes for
T9537 14262-14267 NN denotes NF-κB
T9538 14268-14276 NN denotes activity
T9539 14277-14286 VB denotes involving
T9540 14287-14290 DT denotes the
T9541 14291-14300 JJ denotes canonical
T9542 14301-14303 NN denotes Ig
T9543 14304-14306 NN denotes κB
T9544 14307-14311 NN denotes site
T9545 14313-14315 PRP denotes We
T9546 14316-14320 RB denotes next
T9547 14321-14325 VB denotes used
T9548 14326-14335 NN denotes chromatin
T9549 14336-14355 NN denotes immunoprecipitation
T9550 14356-14358 TO denotes to
T9551 14359-14368 VB denotes determine
T9552 14369-14376 IN denotes whether
T9553 14377-14381 NN denotes S209
T9554 14382-14397 NN denotes phosphorylation
T9555 14398-14405 VB denotes affects
T9556 14406-14410 NN denotes RPS3
T9557 14411-14414 CC denotes and
T9558 14415-14418 NN denotes p65
T9559 14419-14430 NN denotes recruitment
T9560 14431-14433 TO denotes to
T9561 14434-14442 JJ denotes specific
T9562 14443-14445 NN denotes κB
T9563 14446-14451 NN denotes sites
T9564 14452-14454 IN denotes in
T9565 14455-14461 JJ denotes intact
T9566 14462-14471 NN denotes chromatin
T9567 14472-14478 IN denotes during
T9568 14479-14484 NN denotes NF-κB
T9569 14485-14495 NN denotes activation
T9570 14497-14499 IN denotes In
T9571 14500-14504 NN denotes RPS3
T9572 14505-14514 NN denotes knockdown
T9573 14515-14520 NN denotes cells
T9574 14520-14521 -COMMA- denotes ,
T9575 14522-14527 NN denotes PMA+I
T9576 14528-14538 VB denotes stimulated
T9577 14539-14542 DT denotes the
T9578 14543-14554 NN denotes recruitment
T9579 14555-14557 IN denotes of
T9580 14558-14569 RB denotes ectopically
T9581 14570-14579 VB denotes expressed
T9582 14579-14580 -COMMA- denotes ,
T9583 14581-14592 JJ denotes Flag-tagged
T9584 14593-14602 JJ denotes wild-type
T9585 14602-14603 -COMMA- denotes ,
T9586 14604-14607 CC denotes but
T9587 14608-14611 RB denotes not
T9588 14612-14617 NN denotes S209A
T9589 14618-14622 NN denotes RPS3
T9590 14623-14625 TO denotes to
T9591 14626-14629 DT denotes the
T9592 14630-14632 NN denotes κB
T9593 14633-14638 NN denotes sites
T9594 14639-14641 IN denotes of
T9595 14642-14645 DT denotes the
T9596 14646-14652 NN denotes NFKBIA
T9597 14653-14656 CC denotes and
T9598 14657-14660 NN denotes IL8
T9599 14661-14670 NN denotes promoters
T9600 14671-14672 -LRB- denotes (
T9601 14672-14676 NNP denotes Fig.
T9602 14677-14679 NN denotes 5e
T9603 14679-14680 -RRB- denotes )
T9604 14682-14687 IN denotes While
T9605 14688-14698 VB denotes expressing
T9606 14699-14703 NN denotes RPS3
T9607 14704-14709 NN denotes S209A
T9608 14710-14713 VB denotes had
T9609 14714-14716 DT denotes no
T9610 14717-14723 NN denotes impact
T9611 14724-14726 IN denotes on
T9612 14727-14730 NN denotes p65
T9613 14731-14738 JJ denotes nuclear
T9614 14739-14752 NN denotes translocation
T9615 14752-14753 -COMMA- denotes ,
T9616 14754-14756 PRP denotes it
T9617 14757-14770 RB denotes substantially
T9618 14771-14781 VB denotes attenuated
T9619 14782-14785 NN denotes p65
T9620 14786-14797 NN denotes recruitment
T9621 14798-14799 -LRB- denotes (
T9622 14799-14803 NN denotes Fig.
T9623 14804-14806 NN denotes 5e
T9624 14806-14807 -RRB- denotes )
T9625 14809-14819 JJ denotes Additional
T9626 14820-14831 NN denotes experiments
T9627 14832-14840 VB denotes revealed
T9628 14841-14845 IN denotes that
T9629 14846-14849 NN denotes p65
T9630 14850-14860 NN denotes attraction
T9631 14861-14863 TO denotes to
T9632 14864-14880 JJ denotes RPS3-independent
T9633 14881-14886 NN denotes NF-κB
T9634 14887-14893 NN denotes target
T9635 14894-14898 NN denotes gene
T9636 14899-14908 NN denotes promoters
T9637 14909-14913 JJ denotes such
T9638 14914-14916 IN denotes as
T9639 14917-14921 NN denotes CD25
T9640 14922-14925 VB denotes was
T9641 14926-14935 VB denotes increased
T9642 14936-14937 -LRB- denotes (
T9643 14937-14950 NNP denotes Supplementary
T9644 14951-14955 NNP denotes Fig.
T9645 14956-14957 CD denotes 9
T9646 14957-14958 -RRB- denotes )
T9647 14958-14959 -COMMA- denotes ,
T9648 14960-14970 JJ denotes consistent
T9649 14971-14975 IN denotes with
T9650 14976-14979 PRP-DOLLAR- denotes our
T9651 14980-14988 JJ denotes previous
T9652 14989-15002 NN denotes observations6
T9653 15004-15009 EX denotes There
T9654 15010-15013 VB denotes was
T9655 15014-15016 DT denotes no
T9656 15017-15028 JJ denotes significant
T9657 15029-15038 NN denotes Flag-RPS3
T9658 15039-15041 CC denotes or
T9659 15042-15045 NN denotes p65
T9660 15046-15057 NN denotes recruitment
T9661 15058-15060 TO denotes to
T9662 15061-15065 NN denotes ACTB
T9663 15066-15074 NN denotes promoter
T9664 15075-15082 VB denotes lacking
T9665 15083-15085 NN denotes κB
T9666 15086-15091 NN denotes sites
T9667 15092-15093 -LRB- denotes (
T9668 15093-15097 NNP denotes Fig.
T9669 15098-15100 NN denotes 5e
T9670 15100-15101 -RRB- denotes )
T9671 15101-15102 -COMMA- denotes ,
T9672 15103-15113 VB denotes suggesting
T9673 15114-15117 DT denotes the
T9674 15118-15129 NN denotes recruitment
T9675 15130-15133 VB denotes was
T9676 15134-15136 NN denotes κB
T9677 15137-15150 JJ denotes site-specific
T9678 15152-15156 RB denotes Thus
T9679 15156-15157 -COMMA- denotes ,
T9680 15158-15161 DT denotes the
T9681 15162-15173 NN denotes recruitment
T9682 15174-15176 IN denotes of
T9683 15177-15181 NN denotes RPS3
T9684 15182-15184 RB denotes as
T9685 15185-15189 RB denotes well
T9686 15190-15192 IN denotes as
T9687 15193-15196 DT denotes the
T9688 15197-15207 JJ denotes contingent
T9689 15208-15219 NN denotes recruitment
T9690 15220-15222 IN denotes of
T9691 15223-15226 NN denotes p65
T9692 15227-15229 TO denotes to
T9693 15230-15233 JJ denotes key
T9694 15234-15243 NN denotes promoters
T9695 15244-15252 VB denotes depended
T9696 15253-15255 IN denotes on
T9697 15256-15260 NN denotes S209
T9698 15262-15273 NN denotes Interleukin
T9699 15274-15275 CD denotes 8
T9700 15276-15277 -LRB- denotes (
T9701 15277-15281 NN denotes IL-8
T9702 15281-15282 -RRB- denotes )
T9703 15283-15292 NN denotes secretion
T9704 15293-15300 VB denotes induced
T9705 15301-15303 IN denotes by
T9706 15304-15310 CC denotes either
T9707 15311-15312 NN denotes T
T9708 15313-15317 NN denotes cell
T9709 15318-15326 NN denotes receptor
T9710 15327-15328 -LRB- denotes (
T9711 15328-15331 NN denotes TCR
T9712 15331-15332 -RRB- denotes )
T9713 15333-15340 NN denotes agonist
T9714 15341-15352 NN denotes stimulation
T9715 15353-15355 CC denotes or
T9716 15356-15361 NN denotes PMA+I
T9717 15362-15365 VB denotes was
T9718 15366-15375 VB denotes decreased
T9719 15376-15378 IN denotes as
T9720 15379-15380 DT denotes a
T9721 15381-15392 NN denotes consequence
T9722 15393-15395 IN denotes of
T9723 15396-15403 VB denotes reduced
T9724 15404-15412 NN denotes RPS3/p65
T9725 15413-15424 NN denotes recruitment
T9726 15425-15427 TO denotes to
T9727 15428-15431 DT denotes the
T9728 15432-15435 NN denotes IL8
T9729 15436-15438 NN denotes κB
T9730 15439-15444 NN denotes sites
T9731 15445-15447 IN denotes in
T9732 15448-15451 DT denotes the
T9733 15452-15460 NN denotes presence
T9734 15461-15463 IN denotes of
T9735 15464-15469 NN denotes S209A
T9736 15470-15476 NN denotes mutant
T9737 15477-15485 VB denotes compared
T9738 15486-15488 TO denotes to
T9739 15489-15498 JJ denotes wild-type
T9740 15499-15503 NN denotes RPS3
T9741 15504-15505 -LRB- denotes (
T9742 15505-15518 NNP denotes Supplementary
T9743 15519-15523 NNP denotes Fig.
T9744 15524-15526 CD denotes 10
T9745 15526-15527 -RRB- denotes )
T9746 15529-15536 RB denotes However
T9747 15536-15537 -COMMA- denotes ,
T9748 15538-15542 NN denotes cell
T9749 15543-15550 NN denotes surface
T9750 15551-15555 NN denotes CD25
T9751 15556-15566 NN denotes expression
T9752 15567-15570 VB denotes was
T9753 15571-15581 JJ denotes comparable
T9754 15582-15589 IN denotes between
T9755 15590-15593 DT denotes the
T9756 15594-15603 JJ denotes wild-type
T9757 15604-15607 CC denotes and
T9758 15608-15613 NN denotes S209A
T9759 15614-15618 NN denotes RPS3
T9760 15619-15630 VB denotes transfected
T9761 15631-15636 NN denotes cells
T9762 15637-15638 -LRB- denotes (
T9763 15638-15651 JJ denotes Supplementary
T9764 15652-15656 NNP denotes Fig.
T9765 15657-15659 CD denotes 11
T9766 15659-15660 -RRB- denotes )
T9767 15662-15671 RB denotes Therefore
T9768 15671-15672 -COMMA- denotes ,
T9769 15673-15677 NN denotes RPS3
T9770 15678-15682 NN denotes S209
T9771 15683-15698 NN denotes phosphorylation
T9772 15699-15701 IN denotes by
T9773 15702-15706 NN denotes IKKβ
T9774 15707-15709 VB denotes is
T9775 15710-15720 RB denotes apparently
T9776 15721-15729 VB denotes required
T9777 15730-15733 IN denotes for
T9778 15734-15738 NN denotes RPS3
T9779 15739-15741 IN denotes in
T9780 15742-15751 VB denotes directing
T9781 15752-15757 NN denotes NF-κB
T9782 15758-15760 TO denotes to
T9783 15761-15762 DT denotes a
T9784 15763-15771 JJ denotes specific
T9785 15772-15778 NN denotes subset
T9786 15779-15781 IN denotes of
T9787 15782-15788 NN denotes target
T9788 15789-15794 NN denotes genes
T11955 15797-15802 NN denotes NleH1
T11956 15803-15811 VB denotes inhibits
T11957 15812-15816 NN denotes RPS3
T11958 15817-15832 NN denotes phosphorylation
T11959 15833-15835 FW denotes in
T11960 15836-15841 FW denotes vitro
T11961 15842-15846 NN denotes EHEC
T11962 15847-15856 NN denotes pathogens
T11963 15857-15860 VB denotes are
T11964 15861-15870 JJ denotes important
T11965 15871-15880 JJ denotes causative
T11966 15881-15887 NN denotes agents
T11967 15888-15890 IN denotes of
T11968 15891-15895 CC denotes both
T11969 15896-15905 JJ denotes foodborne
T11970 15906-15913 NN denotes disease
T11971 15914-15917 CC denotes and
T11972 15918-15927 JJ denotes pediatric
T11973 15928-15933 JJ denotes renal
T11974 15934-15943 NN denotes failure31
T11975 15945-15949 NN denotes EHEC
T11976 15950-15957 VB denotes utilize
T11977 15958-15962 NN denotes T3SS
T11978 15963-15965 TO denotes to
T11979 15966-15972 VB denotes inject
T11980 15973-15981 NN denotes effector
T11981 15982-15990 NN denotes proteins
T11982 15991-15999 RB denotes directly
T11983 16000-16004 IN denotes into
T11984 16005-16015 JJ denotes intestinal
T11985 16016-16026 JJ denotes epithelial
T11986 16027-16034 NN denotes cells32
T11987 16034-16035 -COMMA- denotes ,
T11988 16036-16037 DT denotes a
T11989 16038-16044 NN denotes subset
T11990 16045-16047 IN denotes of
T11991 16048-16053 WDT denotes which
T11992 16054-16061 VB denotes inhibit
T11993 16062-16077 JJ denotes NF-κB-dependent
T11994 16078-16084 JJ denotes innate
T11995 16085-16095 NN denotes responses9
T11996 16095-16096 -COMMA- denotes ,
T11997 16097-16102 CD denotes 33-38
T11998 16104-16107 DT denotes The
T11999 16108-16110 FW denotes E.
T12000 16111-16115 FW denotes coli
T12001 16116-16120 NN denotes O157
T12002 16120-16121 -COLON- denotes :
T12003 16121-16123 NN denotes H7
T12004 16124-16130 NN denotes EDL933
T12005 16131-16139 NN denotes effector
T12006 16140-16147 NN denotes protein
T12007 16148-16153 NN denotes NleH1
T12008 16154-16159 VB denotes binds
T12009 16160-16162 TO denotes to
T12010 16163-16166 CC denotes and
T12011 16167-16177 VB denotes attenuates
T12012 16178-16182 NN denotes RPS3
T12013 16183-16190 JJ denotes nuclear
T12014 16191-16204 NN denotes translocation
T12015 16204-16205 -COMMA- denotes ,
T12016 16206-16210 RB denotes thus
T12017 16211-16220 VB denotes impairing
T12018 16221-16235 JJ denotes RPS3-dependent
T12019 16236-16241 NN denotes NF-κB
T12020 16242-16252 NN denotes signaling9
T12021 16254-16256 PRP denotes We
T12022 16257-16266 RB denotes therefore
T12023 16267-16279 VB denotes hypothesized
T12024 16280-16284 IN denotes that
T12025 16285-16290 NN denotes NleH1
T12026 16291-16294 MD denotes may
T12027 16295-16303 VB denotes function
T12028 16304-16306 IN denotes by
T12029 16307-16317 VB denotes inhibiting
T12030 16318-16322 NN denotes RPS3
T12031 16323-16327 NN denotes S209
T12032 16328-16343 NN denotes phosphorylation
T12033 16345-16347 IN denotes As
T12034 16348-16356 VB denotes expected
T12035 16356-16357 -COMMA- denotes ,
T12036 16358-16370 VB denotes transfecting
T12037 16371-16381 VB denotes increasing
T12038 16382-16389 NN denotes amounts
T12039 16390-16392 IN denotes of
T12040 16393-16401 NN denotes NleH1-HA
T12041 16402-16409 NN denotes plasmid
T12042 16410-16417 VB denotes blocked
T12043 16418-16430 JJ denotes TNFα-induced
T12044 16431-16436 NN denotes NF-κB
T12045 16437-16447 NN denotes activation
T12046 16448-16450 IN denotes in
T12047 16451-16452 DT denotes a
T12048 16453-16467 JJ denotes dose-dependent
T12049 16468-16474 NN denotes manner
T12050 16475-16476 -LRB- denotes (
T12051 16476-16480 NNP denotes Fig.
T12052 16481-16485 CD denotes 6a-b
T12053 16485-16486 -RRB- denotes )
T12054 16486-16487 CD denotes 9
T12055 16489-16499 RB denotes Remarkably
T12056 16499-16500 -COMMA- denotes ,
T12057 16501-16506 NN denotes NleH1
T12058 16507-16514 VB denotes reduced
T12059 16515-16519 CC denotes both
T12060 16520-16531 JJ denotes TNF-induced
T12061 16531-16532 -COMMA- denotes ,
T12062 16533-16535 RB denotes as
T12063 16536-16540 RB denotes well
T12064 16541-16543 IN denotes as
T12065 16544-16549 JJ denotes basal
T12066 16550-16554 NN denotes RPS3
T12067 16555-16570 NN denotes phosphorylation
T12068 16571-16573 TO denotes to
T12069 16574-16581 RB denotes roughly
T12070 16582-16584 CD denotes 20
T12071 16584-16585 NN denotes %
T12072 16586-16588 IN denotes of
T12073 16589-16596 NN denotes vehicle
T12074 16597-16604 NN denotes control
T12075 16605-16606 -LRB- denotes (
T12076 16606-16610 NNP denotes Fig.
T12077 16611-16613 NN denotes 6c
T12078 16613-16614 -RRB- denotes )
T12079 16616-16626 VB denotes Expressing
T12080 16627-16632 NN denotes NleH1
T12081 16633-16637 VB denotes does
T12082 16638-16641 RB denotes not
T12083 16642-16651 VB denotes interfere
T12084 16652-16656 IN denotes with
T12085 16657-16663 CC denotes either
T12086 16664-16675 JJ denotes TNF-induced
T12087 16676-16679 NN denotes IKK
T12088 16680-16690 NN denotes activation
T12089 16691-16693 CC denotes or
T12090 16694-16698 NN denotes IκBα
T12091 16699-16710 NN denotes degradation
T12092 16710-16711 -COMMA- denotes ,
T12093 16712-16722 JJ denotes consistent
T12094 16723-16727 IN denotes with
T12095 16728-16731 DT denotes the
T12096 16732-16736 NN denotes lack
T12097 16737-16739 IN denotes of
T12098 16740-16745 NN denotes NleH1
T12099 16746-16752 NN denotes impact
T12100 16753-16755 IN denotes on
T12101 16756-16759 NN denotes p65
T12102 16760-16767 JJ denotes nuclear
T12103 16768-16782 NN denotes translocation9
T12104 16783-16784 -LRB- denotes (
T12105 16784-16788 NN denotes Fig.
T12106 16789-16791 NN denotes 6c
T12107 16791-16792 -RRB- denotes )
T12108 16794-16796 TO denotes To
T12109 16797-16806 VB denotes determine
T12110 16807-16809 IN denotes if
T12111 16810-16815 NN denotes NleH1
T12112 16816-16824 VB denotes inhibits
T12113 16825-16829 NN denotes RPS3
T12114 16830-16845 NN denotes phosphorylation
T12115 16845-16846 -COMMA- denotes ,
T12116 16847-16849 PRP denotes we
T12117 16850-16858 VB denotes infected
T12118 16859-16863 NN denotes HeLa
T12119 16864-16869 NN denotes cells
T12120 16870-16874 IN denotes with
T12121 16875-16877 FW denotes E.
T12122 16878-16882 FW denotes coli
T12123 16883-16887 NN denotes O157
T12124 16887-16888 -COLON- denotes :
T12125 16888-16890 NN denotes H7
T12126 16891-16898 NN denotes strains
T12127 16899-16909 VB denotes possessing
T12128 16910-16912 CC denotes or
T12129 16913-16920 VB denotes lacking
T12130 16921-16927 CC denotes either
T12131 16928-16933 NN denotes nleH1
T12132 16934-16935 -LRB- denotes (
T12133 16935-16941 NN denotes ΔnleH1
T12134 16941-16942 -RRB- denotes )
T12135 16943-16945 CC denotes or
T12136 16946-16950 IN denotes with
T12137 16951-16952 DT denotes a
T12138 16953-16959 NN denotes strain
T12139 16960-16967 VB denotes lacking
T12140 16968-16969 DT denotes a
T12141 16970-16980 JJ denotes functional
T12142 16981-16985 NN denotes T3SS
T12143 16986-16992 JJ denotes unable
T12144 16993-16995 TO denotes to
T12145 16996-17002 VB denotes inject
T12146 17003-17008 NN denotes NleH1
T12147 17009-17013 IN denotes into
T12148 17014-17023 JJ denotes mammalian
T12149 17024-17029 NN denotes cells
T12150 17030-17031 -LRB- denotes (
T12151 17031-17036 NN denotes ΔescN
T12152 17036-17037 -RRB- denotes )
T12153 17039-17041 IN denotes In
T12154 17042-17052 JJ denotes uninfected
T12155 17053-17058 NN denotes cells
T12156 17058-17059 -COMMA- denotes ,
T12157 17060-17073 NN denotes TNF-treatment
T12158 17074-17084 VB denotes stimulated
T12159 17085-17086 DT denotes a
T12160 17087-17094 JJ denotes ∼7-fold
T12161 17095-17103 NN denotes increase
T12162 17104-17106 IN denotes in
T12163 17107-17111 NN denotes RPS3
T12164 17112-17116 NN denotes S209
T12165 17117-17132 NN denotes phosphorylation
T12166 17132-17133 -COMMA- denotes ,
T12167 17134-17141 VB denotes peaking
T12168 17142-17144 IN denotes at
T12169 17145-17147 CD denotes 30
T12170 17148-17155 NN denotes minutes
T12171 17156-17157 -LRB- denotes (
T12172 17157-17161 NNP denotes Fig.
T12173 17162-17164 CD denotes 6d
T12174 17164-17165 -RRB- denotes )
T12175 17167-17169 IN denotes By
T12176 17170-17178 NN denotes contrast
T12177 17178-17179 -COMMA- denotes ,
T12178 17180-17184 NN denotes RPS3
T12179 17185-17189 NN denotes S209
T12180 17190-17205 NN denotes phosphorylation
T12181 17206-17209 VB denotes was
T12182 17210-17223 RB denotes substantially
T12183 17224-17232 JJ denotes impaired
T12184 17233-17235 IN denotes in
T12185 17236-17241 NN denotes cells
T12186 17242-17250 VB denotes infected
T12187 17251-17255 IN denotes with
T12188 17256-17265 JJ denotes wild-type
T12189 17266-17268 FW denotes E.
T12190 17269-17273 FW denotes coli
T12191 17274-17278 NN denotes O157
T12192 17278-17279 -COLON- denotes :
T12193 17279-17281 NN denotes H7
T12194 17282-17283 -LRB- denotes (
T12195 17283-17287 NNP denotes Fig.
T12196 17288-17290 CD denotes 6d
T12197 17290-17291 -RRB- denotes )
T12198 17293-17300 RB denotes However
T12199 17300-17301 -COMMA- denotes ,
T12200 17302-17313 JJ denotes TNF-induced
T12201 17314-17318 NN denotes RPS3
T12202 17319-17323 NN denotes S209
T12203 17324-17339 NN denotes phosphorylation
T12204 17340-17343 VB denotes was
T12205 17344-17354 JJ denotes unimpaired
T12206 17355-17357 IN denotes in
T12207 17358-17363 NN denotes cells
T12208 17364-17372 VB denotes infected
T12209 17373-17377 IN denotes with
T12210 17378-17384 CC denotes either
T12211 17385-17391 NN denotes ΔnleH1
T12212 17392-17394 CC denotes or
T12213 17395-17400 NN denotes ΔescN
T12214 17401-17402 -LRB- denotes (
T12215 17402-17406 NNP denotes Fig.
T12216 17407-17409 CD denotes 6d
T12217 17409-17410 -RRB- denotes )
T12218 17412-17414 PRP denotes We
T12219 17415-17421 VB denotes showed
T12220 17422-17432 RB denotes previously
T12221 17433-17437 IN denotes that
T12222 17438-17447 JJ denotes wild-type
T12223 17447-17448 -COMMA- denotes ,
T12224 17449-17452 CC denotes but
T12225 17453-17456 RB denotes not
T12226 17457-17463 NN denotes ΔnleH1
T12227 17464-17466 CC denotes or
T12228 17467-17472 FW denotes ΔescN
T12229 17473-17475 FW denotes E.
T12230 17476-17480 FW denotes coli
T12231 17481-17485 NN denotes O157
T12232 17485-17486 -COLON- denotes :
T12233 17486-17488 NN denotes H7
T12234 17489-17502 RB denotes significantly
T12235 17503-17513 VB denotes attenuated
T12236 17514-17525 JJ denotes TNF-induced
T12237 17526-17530 NN denotes RPS3
T12238 17531-17538 JJ denotes nuclear
T12239 17539-17553 NN denotes translocation9
T12240 17555-17558 DT denotes The
T12241 17559-17567 NN denotes parallel
T12242 17568-17575 IN denotes between
T12243 17576-17580 NN denotes RPS3
T12244 17581-17596 NN denotes phosphorylation
T12245 17597-17600 CC denotes and
T12246 17601-17604 PRP-DOLLAR- denotes its
T12247 17605-17612 JJ denotes nuclear
T12248 17613-17626 NN denotes translocation
T12249 17627-17633 IN denotes during
T12250 17634-17636 FW denotes E.
T12251 17637-17641 FW denotes coli
T12252 17642-17651 NN denotes infection
T12253 17652-17660 VB denotes provides
T12254 17661-17669 NN denotes evidence
T12255 17670-17672 IN denotes in
T12256 17673-17676 DT denotes the
T12257 17677-17684 NN denotes context
T12258 17685-17687 IN denotes of
T12259 17688-17690 DT denotes an
T12260 17691-17706 JJ denotes NF-κB-dependent
T12261 17707-17714 NN denotes disease
T12262 17715-17722 NN denotes process
T12263 17723-17727 IN denotes that
T12264 17728-17732 NN denotes RPS3
T12265 17733-17737 NN denotes S209
T12266 17738-17753 NN denotes phosphorylation
T12267 17754-17756 VB denotes is
T12268 17757-17766 JJ denotes important
T12269 17767-17770 IN denotes for
T12270 17771-17778 JJ denotes nuclear
T12271 17779-17792 NN denotes translocation
T12272 17794-17797 PRP-DOLLAR- denotes Our
T12273 17798-17807 NN denotes discovery
T12274 17808-17812 IN denotes that
T12275 17813-17818 NN denotes NleH1
T12276 17819-17827 VB denotes inhibits
T12277 17828-17832 NN denotes RPS3
T12278 17833-17837 NN denotes S209
T12279 17838-17853 NN denotes phosphorylation
T12280 17854-17863 VB denotes suggested
T12281 17864-17868 IN denotes that
T12282 17869-17871 PRP denotes it
T12283 17872-17878 MD denotes should
T12284 17879-17883 RB denotes also
T12285 17884-17890 VB denotes blocks
T12286 17891-17905 JJ denotes RPS3-dependent
T12287 17906-17911 NN denotes NF-κB
T12288 17912-17918 NN denotes target
T12289 17919-17923 NN denotes gene
T12290 17924-17937 NN denotes transcription
T12291 17938-17939 -LRB- denotes (
T12292 17939-17943 FW denotes e.g.
T12293 17944-17947 NN denotes IL8
T12294 17947-17948 -COMMA- denotes ,
T12295 17949-17955 NN denotes NFKBIA
T12296 17955-17956 -COMMA- denotes ,
T12297 17957-17960 CC denotes and
T12298 17961-17968 NN denotes TNFAIP3
T12299 17968-17969 -RRB- denotes )
T12300 17971-17977 RB denotes Indeed
T12301 17977-17978 -COMMA- denotes ,
T12302 17979-17984 DT denotes these
T12303 17985-17990 NN denotes genes
T12304 17991-17995 VB denotes were
T12305 17996-18000 RB denotes only
T12306 18001-18009 RB denotes modestly
T12307 18010-18021 VB denotes upregulated
T12308 18022-18024 IN denotes in
T12309 18025-18030 NN denotes cells
T12310 18031-18039 VB denotes infected
T12311 18040-18044 IN denotes with
T12312 18045-18054 JJ denotes wild-type
T12313 18055-18057 FW denotes E.
T12314 18058-18062 FW denotes coli
T12315 18063-18067 NN denotes O157
T12316 18067-18068 -COLON- denotes :
T12317 18068-18070 NN denotes H7
T12318 18070-18071 -COMMA- denotes ,
T12319 18072-18075 CC denotes but
T12320 18076-18089 RB denotes significantly
T12321 18090-18097 VB denotes induced
T12322 18098-18100 IN denotes in
T12323 18101-18106 NN denotes cells
T12324 18107-18115 VB denotes infected
T12325 18116-18120 IN denotes with
T12326 18121-18127 CC denotes either
T12327 18128-18134 NN denotes ΔnleH1
T12328 18135-18137 CC denotes or
T12329 18138-18143 NN denotes ΔescN
T12330 18144-18151 NN denotes strains
T12331 18152-18153 -LRB- denotes (
T12332 18153-18157 NNP denotes Fig.
T12333 18158-18160 NNP denotes 6e
T12334 18160-18161 -RRB- denotes )
T12335 18163-18165 IN denotes In
T12336 18166-18174 NN denotes contrast
T12337 18174-18175 -COMMA- denotes ,
T12338 18176-18184 VB denotes deleting
T12339 18185-18190 NN denotes nleH1
T12340 18191-18194 VB denotes had
T12341 18195-18197 DT denotes no
T12342 18198-18204 NN denotes impact
T12343 18205-18207 IN denotes on
T12344 18208-18211 DT denotes the
T12345 18212-18222 NN denotes expression
T12346 18223-18225 IN denotes of
T12347 18226-18242 JJ denotes RPS3-independent
T12348 18243-18248 NN denotes genes
T12349 18248-18249 -COMMA- denotes ,
T12350 18250-18259 VB denotes including
T12351 18260-18264 NN denotes CD25
T12352 18265-18268 CC denotes and
T12353 18269-18277 NN denotes TNFSF13B
T12354 18278-18279 -LRB- denotes (
T12355 18279-18292 NNP denotes Supplementary
T12356 18293-18297 NNP denotes Fig.
T12357 18298-18300 CD denotes 12
T12358 18300-18301 -RRB- denotes )
T12359 18303-18311 RB denotes Together
T12360 18312-18317 DT denotes these
T12361 18318-18325 NN denotes results
T12362 18326-18337 VB denotes demonstrate
T12363 18338-18342 IN denotes that
T12364 18343-18348 NN denotes NleH1
T12365 18349-18361 RB denotes specifically
T12366 18362-18370 VB denotes inhibits
T12367 18371-18374 DT denotes the
T12368 18375-18385 JJ denotes protective
T12369 18386-18392 JJ denotes immune
T12370 18393-18401 NN denotes response
T12371 18402-18404 IN denotes by
T12372 18405-18413 RB denotes directly
T12373 18414-18422 VB denotes blocking
T12374 18423-18427 NN denotes RPS3
T12375 18428-18432 NN denotes S209
T12376 18433-18448 NN denotes phosphorylation
T12377 18449-18452 CC denotes and
T12378 18453-18460 RB denotes thereby
T12379 18461-18470 VB denotes impairing
T12380 18471-18479 JJ denotes critical
T12381 18480-18494 JJ denotes RPS3-dependent
T12382 18495-18500 NN denotes NF-κB
T12383 18501-18507 NN denotes target
T12384 18508-18513 NN denotes genes
T13762 18516-18521 NN denotes NleH1
T13763 18522-18530 VB denotes inhibits
T13764 18531-18535 NN denotes RPS3
T13765 18536-18540 NN denotes S209
T13766 18541-18556 NN denotes phosphorylation
T13767 18557-18559 FW denotes in
T13768 18560-18564 FW denotes vivo
T13769 18565-18567 PRP denotes We
T13770 18568-18578 RB denotes previously
T13771 18579-18587 VB denotes utilized
T13772 18588-18589 DT denotes a
T13773 18590-18601 JJ denotes gnotobiotic
T13774 18602-18608 NN denotes piglet
T13775 18609-18618 NN denotes infection
T13776 18619-18624 NN denotes model
T13777 18625-18627 TO denotes to
T13778 18628-18637 VB denotes determine
T13779 18638-18642 IN denotes that
T13780 18643-18650 NN denotes piglets
T13781 18651-18659 VB denotes infected
T13782 18660-18664 IN denotes with
T13783 18665-18671 NN denotes ΔnleH1
T13784 18672-18678 NN denotes mutant
T13785 18679-18683 VB denotes died
T13786 18684-18688 RB denotes more
T13787 18689-18696 RB denotes rapidly
T13788 18697-18701 IN denotes than
T13789 18702-18707 DT denotes those
T13790 18708-18716 VB denotes infected
T13791 18717-18721 IN denotes with
T13792 18722-18731 JJ denotes wild-type
T13793 18732-18734 FW denotes E.
T13794 18735-18739 FW denotes coli
T13795 18740-18744 NN denotes O157
T13796 18744-18745 -COLON- denotes :
T13797 18745-18747 NN denotes H7
T13798 18749-18756 NN denotes Piglets
T13799 18757-18765 VB denotes infected
T13800 18766-18770 IN denotes with
T13801 18771-18777 NN denotes ΔnleH1
T13802 18778-18787 VB denotes displayed
T13803 18788-18796 JJ denotes clinical
T13804 18797-18804 NN denotes disease
T13805 18805-18815 JJ denotes consistent
T13806 18816-18820 IN denotes with
T13807 18821-18822 DT denotes a
T13808 18823-18829 JJ denotes robust
T13809 18830-18842 JJ denotes inflammatory
T13810 18843-18851 NN denotes response
T13811 18851-18852 -COMMA- denotes ,
T13812 18853-18856 CC denotes but
T13813 18857-18861 IN denotes with
T13814 18862-18869 VB denotes reduced
T13815 18870-18879 JJ denotes bacterial
T13816 18880-18892 NN denotes colonization
T13817 18893-18896 CC denotes and
T13818 18897-18903 JJ denotes little
T13819 18904-18913 NN denotes diarrhea9
T13820 18915-18920 IN denotes While
T13821 18921-18930 RB denotes seemingly
T13822 18931-18942 JJ denotes paradoxical
T13823 18942-18943 -COMMA- denotes ,
T13824 18944-18949 VB denotes based
T13825 18950-18952 IN denotes on
T13826 18953-18956 PRP-DOLLAR- denotes our
T13827 18957-18961 NN denotes cell
T13828 18962-18969 NN denotes culture
T13829 18970-18974 NN denotes data
T13830 18975-18976 -LRB- denotes (
T13831 18976-18980 NNP denotes Fig.
T13832 18981-18983 NNP denotes 6d
T13833 18983-18984 -RRB- denotes )
T13834 18984-18985 -COMMA- denotes ,
T13835 18986-18988 PRP denotes we
T13836 18989-19001 VB denotes hypothesized
T13837 19002-19006 IN denotes that
T13838 19007-19012 NN denotes NleH1
T13839 19013-19020 VB denotes blocked
T13840 19021-19025 NN denotes RPS3
T13841 19026-19030 NN denotes S209
T13842 19031-19046 NN denotes phosphorylation
T13843 19047-19049 FW denotes in
T13844 19050-19054 FW denotes vivo
T13845 19054-19055 -COMMA- denotes ,
T13846 19056-19063 RB denotes thereby
T13847 19064-19074 VB denotes preventing
T13848 19075-19079 NN denotes RPS3
T13849 19080-19087 JJ denotes nuclear
T13850 19088-19101 NN denotes translocation
T13851 19102-19104 IN denotes in
T13852 19105-19113 JJ denotes infected
T13853 19114-19121 NN denotes piglets
T13854 19123-19125 PRP denotes We
T13855 19126-19134 VB denotes isolated
T13856 19135-19141 NN denotes piglet
T13857 19142-19148 NN denotes colons
T13858 19149-19151 IN denotes at
T13859 19152-19160 NN denotes necropsy
T13860 19160-19161 -COMMA- denotes ,
T13861 19162-19165 CC denotes and
T13862 19166-19175 VB denotes subjected
T13863 19176-19180 PRP denotes them
T13864 19181-19183 TO denotes to
T13865 19184-19204 NN denotes immunohistochemistry
T13866 19205-19210 VB denotes using
T13867 19211-19214 PRP-DOLLAR- denotes our
T13868 19215-19227 NN denotes phospho-RPS3
T13869 19228-19236 NN denotes antibody
T13870 19238-19248 JJ denotes Consistent
T13871 19249-19253 IN denotes with
T13872 19254-19256 FW denotes in
T13873 19257-19262 FW denotes vitro
T13874 19263-19267 NN denotes data
T13875 19267-19268 -COMMA- denotes ,
T13876 19269-19276 NN denotes piglets
T13877 19277-19285 VB denotes infected
T13878 19286-19290 IN denotes with
T13879 19291-19300 JJ denotes wild-type
T13880 19301-19303 FW denotes E.
T13881 19304-19308 FW denotes coli
T13882 19309-19313 NN denotes O157
T13883 19313-19314 -COLON- denotes :
T13884 19314-19316 NN denotes H7
T13885 19317-19326 VB denotes exhibited
T13886 19327-19334 JJ denotes diffuse
T13887 19335-19338 CC denotes and
T13888 19339-19342 JJ denotes low
T13889 19343-19352 NN denotes intensity
T13890 19353-19365 NN denotes phospho-RPS3
T13891 19366-19374 NN denotes staining
T13892 19374-19375 -COMMA- denotes ,
T13893 19376-19383 IN denotes whereas
T13894 19384-19386 IN denotes in
T13895 19387-19394 NN denotes piglets
T13896 19395-19403 VB denotes infected
T13897 19404-19408 IN denotes with
T13898 19409-19415 NN denotes ΔnleH1
T13899 19416-19422 NN denotes mutant
T13900 19422-19423 -COMMA- denotes ,
T13901 19424-19436 NN denotes phospho-RPS3
T13902 19437-19447 NN denotes expression
T13903 19448-19451 VB denotes was
T13904 19452-19458 JJ denotes florid
T13905 19459-19462 CC denotes and
T13906 19463-19470 JJ denotes intense
T13907 19471-19472 -LRB- denotes (
T13908 19472-19476 NNP denotes Fig.
T13909 19477-19479 CD denotes 6f
T13910 19479-19480 -RRB- denotes )
T13911 19482-19487 DT denotes These
T13912 19488-19492 NN denotes data
T13913 19493-19504 VB denotes demonstrate
T13914 19505-19509 IN denotes that
T13915 19510-19515 NN denotes NleH1
T13916 19516-19524 VB denotes inhibits
T13917 19525-19529 NN denotes RPS3
T13918 19530-19534 NN denotes S209
T13919 19535-19550 NN denotes phosphorylation
T13920 19551-19555 CC denotes both
T13921 19556-19558 FW denotes in
T13922 19559-19564 FW denotes vitro
T13923 19565-19568 CC denotes and
T13924 19569-19571 FW denotes in
T13925 19572-19576 FW denotes vivo
T13926 19576-19577 -COMMA- denotes ,
T13927 19578-19583 WDT denotes which
T13928 19584-19589 MD denotes might
T13929 19590-19597 VB denotes benefit
T13930 19598-19601 DT denotes the
T13931 19602-19611 NN denotes bacterium
T13932 19612-19614 IN denotes in
T13933 19615-19627 NN denotes colonization
T13934 19628-19631 CC denotes and
T13935 19632-19644 NN denotes transmission
T14934 19647-19652 NN denotes NleH1
T14935 19653-19659 NN denotes steers
T14936 19660-19663 DT denotes the
T14937 19664-19668 NN denotes IKKβ
T14938 19669-19678 NN denotes substrate
T14939 19679-19692 NN denotes specificities
T14940 19693-19698 NN denotes NleH1
T14941 19699-19701 VB denotes is
T14942 19702-19704 DT denotes an
T14943 19705-19723 VB denotes autophosphorylated
T14944 19724-19740 NN denotes serine-threonine
T14945 19741-19747 NN denotes kinase
T14946 19747-19748 -COMMA- denotes ,
T14947 19749-19754 WDT denotes which
T14948 19755-19762 VB denotes depends
T14949 19763-19765 IN denotes on
T14950 19766-19769 DT denotes the
T14951 19770-19776 NN denotes lysine
T14952 19777-19780 CD denotes 159
T14953 19781-19782 -LRB- denotes (
T14954 19782-19786 NN denotes K159
T14955 19786-19787 -RRB- denotes )
T14956 19787-19788 CD denotes 9
T14957 19790-19792 TO denotes To
T14958 19793-19800 VB denotes explore
T14959 19801-19804 DT denotes the
T14960 19805-19814 NN denotes mechanism
T14961 19815-19817 IN denotes by
T14962 19818-19823 WDT denotes which
T14963 19824-19829 NN denotes NleH1
T14964 19830-19838 VB denotes inhibits
T14965 19839-19843 NN denotes RPS3
T14966 19844-19848 NN denotes S209
T14967 19849-19864 NN denotes phosphorylation
T14968 19864-19865 -COMMA- denotes ,
T14969 19866-19868 PRP denotes we
T14970 19869-19874 RB denotes first
T14971 19875-19884 VB denotes performed
T14972 19885-19887 DT denotes an
T14973 19888-19890 FW denotes in
T14974 19891-19896 FW denotes vitro
T14975 19897-19903 NN denotes kinase
T14976 19904-19909 NN denotes assay
T14977 19910-19914 IN denotes with
T14978 19915-19923 VB denotes purified
T14979 19924-19933 JJ denotes wild-type
T14980 19934-19943 NN denotes His-NleH1
T14981 19944-19951 NN denotes protein
T14982 19952-19955 CC denotes and
T14983 19956-19957 DT denotes a
T14984 19958-19964 JJ denotes mutant
T14985 19965-19974 NN denotes His-NleH1
T14986 19975-19976 -LRB- denotes (
T14987 19976-19981 NN denotes K159A
T14988 19981-19982 -RRB- denotes )
T14989 19983-19990 NN denotes protein
T14990 19990-19991 -COMMA- denotes ,
T14991 19992-20002 VB denotes confirming
T14992 20003-20007 IN denotes that
T14993 20008-20013 NN denotes NleH1
T14994 20014-20016 VB denotes is
T14995 20017-20035 VB denotes autophosphorylated
T14996 20036-20039 CC denotes and
T14997 20040-20043 DT denotes the
T14998 20044-20049 NN denotes K159A
T14999 20050-20052 VB denotes is
T15000 20053-20055 DT denotes an
T15001 20056-20061 NN denotes NleH1
T15002 20062-20073 NN denotes kinase-dead
T15003 20074-20080 NN denotes mutant
T15004 20081-20082 -LRB- denotes (
T15005 20082-20086 NN denotes Fig.
T15006 20087-20089 NN denotes 7a
T15007 20089-20090 -RRB- denotes )
T15008 20092-20094 TO denotes To
T15009 20095-20102 VB denotes examine
T15010 20103-20110 IN denotes whether
T15011 20111-20114 DT denotes the
T15012 20115-20121 NN denotes kinase
T15013 20122-20130 NN denotes activity
T15014 20131-20133 VB denotes is
T15015 20134-20142 VB denotes required
T15016 20143-20146 IN denotes for
T15017 20147-20152 NN denotes NleH1
T15018 20153-20155 TO denotes to
T15019 20156-20163 VB denotes inhibit
T15020 20164-20168 NN denotes IKKβ
T15021 20169-20184 NN denotes phosphorlyation
T15022 20185-20187 IN denotes of
T15023 20188-20192 NN denotes RPS3
T15024 20193-20195 IN denotes on
T15025 20196-20200 NN denotes S209
T15026 20200-20201 -COMMA- denotes ,
T15027 20202-20204 PRP denotes we
T15028 20205-20216 RB denotes ectopically
T15029 20217-20227 VB denotes expressing
T15030 20228-20234 CC denotes either
T15031 20235-20244 JJ denotes wild-type
T15032 20245-20247 CC denotes or
T15033 20248-20253 NN denotes K159A
T15034 20254-20259 NN denotes NleH1
T15035 20260-20262 IN denotes in
T15036 20263-20267 NN denotes 293T
T15037 20268-20273 NN denotes cells
T15038 20275-20284 JJ denotes Wild-type
T15039 20285-20290 NN denotes NleH1
T15040 20291-20301 NN denotes expression
T15041 20302-20315 RB denotes significantly
T15042 20316-20323 VB denotes reduced
T15043 20324-20335 JJ denotes TNF-induced
T15044 20336-20340 NN denotes RPS3
T15045 20341-20345 NN denotes S209
T15046 20346-20361 NN denotes phosphorylation
T15047 20361-20362 -COMMA- denotes ,
T15048 20363-20370 IN denotes whereas
T15049 20371-20374 DT denotes the
T15050 20375-20380 NN denotes K159A
T15051 20381-20387 NN denotes mutant
T15052 20388-20394 VB denotes failed
T15053 20395-20397 TO denotes to
T15054 20398-20400 VB denotes do
T15055 20401-20403 RB denotes so
T15056 20404-20405 -LRB- denotes (
T15057 20405-20409 NNP denotes Fig.
T15058 20410-20412 NN denotes 7b
T15059 20412-20413 -RRB- denotes )
T15060 20415-20419 RB denotes Thus
T15061 20420-20425 NN denotes NleH1
T15062 20426-20432 NN denotes kinase
T15063 20433-20441 NN denotes activity
T15064 20442-20444 VB denotes is
T15065 20445-20453 VB denotes required
T15066 20454-20456 TO denotes to
T15067 20457-20464 VB denotes protect
T15068 20465-20469 NN denotes RPS3
T15069 20470-20474 IN denotes from
T15070 20475-20488 JJ denotes IKKβ-mediated
T15071 20489-20504 NN denotes phosphorylation
T15072 20506-20517 NN denotes Citrobacter
T15073 20518-20527 NN denotes rodentium
T15074 20528-20530 VB denotes is
T15075 20531-20532 DT denotes a
T15076 20533-20538 NN denotes mouse
T15077 20539-20547 NN denotes pathogen
T15078 20548-20552 WDT denotes that
T15079 20553-20559 VB denotes shares
T15080 20560-20570 JJ denotes pathogenic
T15081 20571-20581 NN denotes strategies
T15082 20582-20586 IN denotes with
T15083 20587-20589 FW denotes E.
T15084 20590-20594 FW denotes coli
T15085 20595-20597 CD denotes 39
T15086 20597-20598 -COMMA- denotes ,
T15087 20599-20603 RB denotes most
T15088 20604-20611 RB denotes notably
T15089 20612-20615 IN denotes for
T15090 20616-20619 PRP-DOLLAR- denotes our
T15091 20620-20633 NN denotes investigation
T15092 20633-20634 -COMMA- denotes ,
T15093 20635-20637 NNP denotes C.
T15094 20638-20647 NN denotes rodentium
T15095 20648-20652 NN denotes NleH
T15096 20653-20662 VB denotes inhibited
T15097 20663-20667 NN denotes RPS3
T15098 20668-20675 JJ denotes nuclear
T15099 20676-20689 NN denotes translocation
T15100 20690-20693 CC denotes and
T15101 20694-20708 JJ denotes RPS3-dependent
T15102 20709-20714 NN denotes NF-κB
T15103 20715-20725 NN denotes luciferase
T15104 20726-20734 NN denotes activity
T15105 20735-20737 TO denotes to
T15106 20738-20740 DT denotes an
T15107 20741-20747 NN denotes extent
T15108 20748-20758 JJ denotes equivalent
T15109 20759-20761 TO denotes to
T15110 20762-20764 FW denotes E.
T15111 20765-20769 FW denotes coli
T15112 20770-20775 NN denotes NleH1
T15113 20776-20777 -LRB- denotes (
T15114 20777-20780 NN denotes ref
T15115 20782-20783 CD denotes 9
T15116 20783-20784 -RRB- denotes )
T15117 20786-20788 PRP denotes We
T15118 20789-20796 VB denotes assayed
T15119 20797-20801 NN denotes RPS3
T15120 20802-20806 NN denotes S209
T15121 20807-20822 NN denotes phosphorylation
T15122 20823-20825 IN denotes in
T15123 20826-20830 NN denotes HeLa
T15124 20831-20836 NN denotes cells
T15125 20837-20845 VB denotes infected
T15126 20846-20850 IN denotes with
T15127 20851-20860 JJ denotes different
T15128 20861-20863 NNP denotes C.
T15129 20864-20873 NN denotes rodentium
T15130 20874-20881 NN denotes strains
T15131 20883-20885 IN denotes In
T15132 20886-20896 JJ denotes uninfected
T15133 20897-20902 NN denotes cells
T15134 20902-20903 -COMMA- denotes ,
T15135 20904-20917 NN denotes TNF-treatment
T15136 20918-20928 VB denotes stimulated
T15137 20929-20930 DT denotes a
T15138 20931-20940 JJ denotes ∼3.5-fold
T15139 20941-20949 NN denotes increase
T15140 20950-20952 IN denotes in
T15141 20953-20957 NN denotes RPS3
T15142 20958-20962 NN denotes S209
T15143 20963-20978 NN denotes phosphorylation
T15144 20979-20980 -LRB- denotes (
T15145 20980-20984 NN denotes Fig.
T15146 20985-20987 NN denotes 7c
T15147 20987-20988 -RRB- denotes )
T15148 20990-20994 JJ denotes Such
T15149 20995-21007 NN denotes augmentation
T15150 21008-21010 IN denotes of
T15151 21011-21015 NN denotes RPS3
T15152 21016-21031 NN denotes phosphorylation
T15153 21032-21035 VB denotes was
T15154 21036-21043 VB denotes reduced
T15155 21044-21046 IN denotes by
T15156 21047-21052 RB denotes about
T15157 21053-21055 CD denotes 60
T15158 21055-21056 NN denotes %
T15159 21057-21059 IN denotes by
T15160 21060-21069 JJ denotes wild-type
T15161 21070-21072 FW denotes C.
T15162 21073-21082 NN denotes rodentium
T15163 21083-21092 NN denotes infection
T15164 21093-21094 -LRB- denotes (
T15165 21094-21098 NN denotes Fig.
T15166 21099-21101 NN denotes 7c
T15167 21101-21102 -RRB- denotes )
T15168 21104-21111 RB denotes However
T15169 21111-21112 -COMMA- denotes ,
T15170 21113-21117 NN denotes RPS3
T15171 21118-21133 NN denotes phosphorylation
T15172 21134-21137 VB denotes was
T15173 21138-21146 VB denotes enhanced
T15174 21147-21151 WRB denotes when
T15175 21152-21157 NN denotes cells
T15176 21158-21162 VB denotes were
T15177 21163-21171 VB denotes infected
T15178 21172-21176 IN denotes with
T15179 21177-21178 DT denotes a
T15180 21179-21181 NNP denotes C.
T15181 21182-21191 NN denotes rodentium
T15182 21192-21198 NN denotes strain
T15183 21199-21206 VB denotes lacking
T15184 21207-21211 NN denotes NleH
T15185 21212-21213 -LRB- denotes (
T15186 21213-21217 NNP denotes Fig.
T15187 21218-21220 NN denotes 7c
T15188 21220-21221 -COMMA- denotes ,
T15189 21222-21227 NN denotes ΔnleH
T15190 21227-21228 -RRB- denotes )
T15191 21230-21232 PRP denotes We
T15192 21233-21240 RB denotes further
T15193 21241-21249 VB denotes examined
T15194 21250-21253 DT denotes the
T15195 21254-21258 NN denotes role
T15196 21259-21261 IN denotes of
T15197 21262-21267 NN denotes NleH1
T15198 21268-21274 NN denotes kinase
T15199 21275-21283 NN denotes activity
T15200 21284-21289 VB denotes using
T15201 21290-21293 DT denotes the
T15202 21294-21296 NNP denotes C.
T15203 21297-21306 NN denotes rodentium
T15204 21307-21312 NN denotes ΔnleH
T15205 21313-21319 NN denotes strain
T15206 21320-21322 IN denotes as
T15207 21323-21324 DT denotes a
T15208 21325-21335 NN denotes background
T15209 21336-21338 IN denotes on
T15210 21339-21344 WDT denotes which
T15211 21345-21347 TO denotes to
T15212 21348-21355 VB denotes express
T15213 21356-21362 CC denotes either
T15214 21363-21372 JJ denotes wild-type
T15215 21373-21375 CC denotes or
T15216 21376-21381 NN denotes K159A
T15217 21382-21384 FW denotes E.
T15218 21385-21389 FW denotes coli
T15219 21390-21395 NN denotes NleH1
T15220 21397-21410 VB denotes Complementing
T15221 21411-21416 NN denotes ΔnleH
T15222 21417-21423 NN denotes mutant
T15223 21424-21428 IN denotes with
T15224 21429-21438 JJ denotes wild-type
T15225 21439-21444 NN denotes NleH1
T15226 21445-21451 RB denotes almost
T15227 21452-21461 VB denotes abolished
T15228 21462-21473 JJ denotes TNF-induced
T15229 21474-21478 NN denotes RPS3
T15230 21479-21483 NN denotes S209
T15231 21484-21499 NN denotes phosphorylation
T15232 21500-21507 IN denotes whereas
T15233 21508-21521 VB denotes complementing
T15234 21522-21526 IN denotes with
T15235 21527-21532 NN denotes K159A
T15236 21533-21539 VB denotes failed
T15237 21540-21542 TO denotes to
T15238 21543-21550 VB denotes inhibit
T15239 21551-21555 NN denotes RPS3
T15240 21556-21571 NN denotes phosphorylation
T15241 21572-21573 -LRB- denotes (
T15242 21573-21577 NN denotes Fig.
T15243 21578-21580 NN denotes 7c
T15244 21580-21581 -RRB- denotes )
T15245 21583-21595 RB denotes Collectively
T15246 21595-21596 -COMMA- denotes ,
T15247 21597-21602 DT denotes these
T15248 21603-21610 NN denotes results
T15249 21611-21622 VB denotes demonstrate
T15250 21623-21627 IN denotes that
T15251 21628-21633 NN denotes NleH1
T15252 21634-21640 NN denotes kinase
T15253 21641-21649 NN denotes activity
T15254 21650-21652 VB denotes is
T15255 21653-21661 VB denotes required
T15256 21662-21664 TO denotes to
T15257 21665-21670 VB denotes block
T15258 21671-21675 NN denotes RPS3
T15259 21676-21680 NN denotes S209
T15260 21681-21696 NN denotes phosphorylation
T15261 21698-21700 PRP denotes We
T15262 21701-21705 RB denotes next
T15263 21706-21714 VB denotes examined
T15264 21715-21722 IN denotes whether
T15265 21723-21726 DT denotes the
T15266 21727-21737 JJ denotes inhibitory
T15267 21738-21746 NN denotes activity
T15268 21747-21749 IN denotes of
T15269 21750-21755 NN denotes NleH1
T15270 21756-21758 VB denotes is
T15271 21759-21771 RB denotes sufficiently
T15272 21772-21778 JJ denotes robust
T15273 21779-21781 TO denotes to
T15274 21782-21788 VB denotes impair
T15275 21789-21792 DT denotes the
T15276 21793-21799 JJ denotes strong
T15277 21800-21807 JJ denotes nuclear
T15278 21808-21821 NN denotes translocation
T15279 21822-21824 IN denotes of
T15280 21825-21829 NN denotes RPS3
T15281 21830-21837 VB denotes trigged
T15282 21838-21840 IN denotes by
T15283 21841-21844 DT denotes the
T15284 21845-21866 JJ denotes constitutively-active
T15285 21867-21871 NN denotes IKKβ
T15286 21872-21873 -LRB- denotes (
T15287 21873-21877 NN denotes IKKβ
T15288 21878-21879 -LRB- denotes [
T15289 21879-21883 NN denotes SSEE
T15290 21883-21884 -RRB- denotes ]
T15291 21884-21885 -RRB- denotes )
T15292 21886-21887 -LRB- denotes (
T15293 21887-21891 NNP denotes Fig.
T15294 21892-21894 NNP denotes 2d
T15295 21894-21895 -RRB- denotes )
T15296 21897-21899 PRP denotes We
T15297 21900-21905 VB denotes found
T15298 21906-21910 IN denotes that
T15299 21911-21922 RB denotes ectopically
T15300 21923-21933 VB denotes expressing
T15301 21934-21940 CC denotes either
T15302 21941-21950 JJ denotes wild-type
T15303 21951-21953 CC denotes or
T15304 21954-21958 NN denotes SSEE
T15305 21959-21963 NN denotes IKKβ
T15306 21964-21972 NN denotes proteins
T15307 21972-21973 -COMMA- denotes ,
T15308 21974-21983 VB denotes triggered
T15309 21984-21988 JJ denotes more
T15310 21989-21993 NN denotes RPS3
T15311 21994-22001 JJ denotes nuclear
T15312 22002-22015 NN denotes translocation
T15313 22016-22020 IN denotes than
T15314 22021-22024 DT denotes the
T15315 22025-22036 JJ denotes kinase-dead
T15316 22037-22041 NN denotes IKKβ
T15317 22042-22043 -LRB- denotes (
T15318 22043-22047 NN denotes SSAA
T15319 22047-22048 -RRB- denotes )
T15320 22049-22056 NN denotes protein
T15321 22057-22058 -LRB- denotes (
T15322 22058-22062 NNP denotes Fig.
T15323 22063-22065 NNP denotes 7d
T15324 22065-22066 -RRB- denotes )
T15325 22068-22072 NN denotes RPS3
T15326 22073-22080 JJ denotes nuclear
T15327 22081-22093 NN denotes accumulation
T15328 22094-22097 VB denotes was
T15329 22098-22111 RB denotes substantially
T15330 22112-22120 VB denotes retarded
T15331 22121-22123 IN denotes by
T15332 22124-22133 VB denotes infecting
T15333 22134-22139 NN denotes cells
T15334 22140-22144 IN denotes with
T15335 22145-22154 JJ denotes wild-type
T15336 22155-22157 FW denotes E.
T15337 22158-22162 FW denotes coli
T15338 22163-22167 NN denotes O157
T15339 22167-22168 -COLON- denotes :
T15340 22168-22170 NN denotes H7
T15341 22171-22172 -LRB- denotes (
T15342 22172-22176 NNP denotes Fig.
T15343 22177-22179 NNP denotes 7d
T15344 22179-22180 -RRB- denotes )
T15345 22182-22184 IN denotes In
T15346 22185-22193 NN denotes contrast
T15347 22193-22194 -COMMA- denotes ,
T15348 22195-22204 VB denotes infecting
T15349 22205-22209 IN denotes with
T15350 22210-22216 CC denotes either
T15351 22217-22223 NN denotes ΔnleH1
T15352 22224-22226 CC denotes or
T15353 22227-22232 NN denotes ΔescN
T15354 22233-22240 NN denotes strains
T15355 22241-22245 RB denotes only
T15356 22246-22254 RB denotes slightly
T15357 22255-22263 JJ denotes impaired
T15358 22264-22268 NN denotes RPS3
T15359 22269-22276 JJ denotes nuclear
T15360 22277-22290 NN denotes translocation
T15361 22291-22293 IN denotes in
T15362 22294-22300 CC denotes either
T15363 22301-22306 NN denotes IKKβ-
T15364 22307-22309 CC denotes or
T15365 22310-22314 NN denotes IKKβ
T15366 22315-22316 -LRB- denotes (
T15367 22316-22320 NN denotes SSEE
T15368 22320-22321 -RRB- denotes )
T15369 22321-22332 JJ denotes -expressing
T15370 22333-22338 NN denotes cells
T15371 22339-22340 -LRB- denotes (
T15372 22340-22344 NNP denotes Fig.
T15373 22345-22347 NNP denotes 7d
T15374 22347-22348 -RRB- denotes )
T15375 22350-22352 IN denotes As
T15376 22353-22361 VB denotes expected
T15377 22361-22362 -COMMA- denotes ,
T15378 22363-22365 NNP denotes E.
T15379 22366-22370 NNP denotes coli
T15380 22371-22381 NN denotes infections
T15381 22382-22385 VB denotes did
T15382 22386-22389 RB denotes not
T15383 22390-22396 VB denotes affect
T15384 22397-22400 DT denotes the
T15385 22401-22405 NN denotes RPS3
T15386 22406-22413 JJ denotes nuclear
T15387 22414-22427 NN denotes translocation
T15388 22428-22430 IN denotes in
T15389 22431-22435 NN denotes IKKβ
T15390 22436-22437 -LRB- denotes (
T15391 22437-22441 NN denotes SSAA
T15392 22441-22442 -RRB- denotes )
T15393 22442-22453 JJ denotes -expressing
T15394 22454-22459 NN denotes cells
T15395 22459-22460 -COMMA- denotes ,
T15396 22461-22466 WRB denotes where
T15397 22467-22472 NN denotes NF-κB
T15398 22473-22482 NN denotes signaling
T15399 22483-22486 VB denotes was
T15400 22487-22490 JJ denotes low
T15401 22491-22492 -LRB- denotes (
T15402 22492-22496 NNP denotes Fig.
T15403 22497-22499 NNP denotes 7d
T15404 22499-22500 -RRB- denotes )
T15405 22502-22506 RB denotes Thus
T15406 22506-22507 -COMMA- denotes ,
T15407 22508-22514 IN denotes during
T15408 22515-22524 NN denotes infection
T15409 22525-22530 NN denotes NleH1
T15410 22531-22533 VB denotes is
T15411 22534-22546 RB denotes sufficiently
T15412 22547-22553 JJ denotes potent
T15413 22554-22556 TO denotes to
T15414 22557-22564 VB denotes inhibit
T15415 22565-22569 NN denotes RPS3
T15416 22570-22577 JJ denotes nuclear
T15417 22578-22591 NN denotes translocation
T15418 22592-22596 RB denotes even
T15419 22597-22599 IN denotes in
T15420 22600-22605 NN denotes cells
T15421 22606-22616 VB denotes expressing
T15422 22617-22641 JJ denotes constitutively-activated
T15423 22642-22646 NN denotes IKKβ
T15424 22648-22650 PRP denotes We
T15425 22651-22659 VB denotes examined
T15426 22660-22667 IN denotes whether
T15427 22668-22673 NN denotes NleH1
T15428 22674-22679 MD denotes could
T15429 22680-22688 RB denotes directly
T15430 22689-22702 VB denotes phosphorylate
T15431 22703-22707 NN denotes IKKβ
T15432 22708-22712 RB denotes thus
T15433 22713-22723 VB denotes inhibiting
T15434 22724-22737 JJ denotes IKKβ-mediated
T15435 22738-22742 NN denotes RPS3
T15436 22743-22747 NN denotes S209
T15437 22748-22763 NN denotes phosphorylation
T15438 22765-22767 PRP denotes We
T15439 22768-22777 VB denotes performed
T15440 22778-22780 FW denotes in
T15441 22781-22786 FW denotes vitro
T15442 22787-22793 NN denotes kinase
T15443 22794-22800 NN denotes assays
T15444 22801-22806 VB denotes using
T15445 22807-22825 VB denotes immunoprecipitated
T15446 22826-22835 NN denotes Flag-IKKβ
T15447 22836-22837 -LRB- denotes (
T15448 22837-22841 NN denotes K44A
T15449 22841-22842 -RRB- denotes )
T15450 22843-22845 IN denotes as
T15451 22846-22855 NN denotes substrate
T15452 22856-22859 CC denotes and
T15453 22860-22871 JJ denotes recombinant
T15454 22872-22881 NN denotes His-NleH1
T15455 22882-22884 IN denotes as
T15456 22885-22891 NN denotes kinase
T15457 22891-22892 -COMMA- denotes ,
T15458 22893-22895 IN denotes so
T15459 22896-22900 IN denotes that
T15460 22901-22905 NN denotes IKKβ
T15461 22906-22925 NN denotes autophosphorylation
T15462 22926-22931 MD denotes would
T15463 22932-22935 RB denotes not
T15464 22936-22943 VB denotes obscure
T15465 22944-22957 JJ denotes NleH1-induced
T15466 22958-22973 NN denotes phosphorylation
T15467 22975-22982 RB denotes However
T15468 22982-22983 -COMMA- denotes ,
T15469 22984-22986 PRP denotes we
T15470 22987-22990 VB denotes did
T15471 22991-22994 RB denotes not
T15472 22995-23002 VB denotes observe
T15473 23003-23006 DT denotes any
T15474 23007-23017 JJ denotes detectable
T15475 23018-23021 NN denotes 32P
T15476 23022-23035 NN denotes incorporation
T15477 23036-23038 IN denotes in
T15478 23039-23043 NN denotes IKKβ
T15479 23044-23045 -LRB- denotes (
T15480 23045-23058 NNP denotes Supplementary
T15481 23059-23063 NNP denotes Fig.
T15482 23064-23066 CD denotes 13
T15483 23066-23067 -RRB- denotes )
T15484 23067-23068 -COMMA- denotes ,
T15485 23069-23073 RB denotes thus
T15486 23074-23080 VB denotes ruling
T15487 23081-23084 RP denotes out
T15488 23085-23089 DT denotes this
T15489 23090-23101 NN denotes possibility
T15490 23103-23105 PRP denotes We
T15491 23106-23110 RB denotes then
T15492 23111-23117 VB denotes tested
T15493 23118-23121 DT denotes the
T15494 23122-23132 NN denotes hypothesis
T15495 23133-23137 IN denotes that
T15496 23138-23143 NN denotes NleH1
T15497 23144-23149 MD denotes could
T15498 23150-23155 VB denotes alter
T15499 23156-23159 DT denotes the
T15500 23160-23164 NN denotes IKKβ
T15501 23165-23174 NN denotes substrate
T15502 23175-23188 NN denotes specificities
T15503 23190-23192 TO denotes To
T15504 23193-23197 DT denotes this
T15505 23198-23201 NN denotes end
T15506 23201-23202 -COMMA- denotes ,
T15507 23203-23205 PRP denotes we
T15508 23206-23215 VB denotes performed
T15509 23216-23218 FW denotes in
T15510 23219-23224 FW denotes vitro
T15511 23225-23231 NN denotes kinase
T15512 23232-23238 NN denotes assays
T15513 23239-23244 VB denotes using
T15514 23245-23249 CC denotes both
T15515 23250-23253 NN denotes CK2
T15516 23254-23257 CC denotes and
T15517 23258-23261 NN denotes IKK
T15518 23262-23272 NN denotes substrates
T15519 23273-23276 IN denotes for
T15520 23277-23281 NN denotes IKKβ
T15521 23283-23285 IN denotes As
T15522 23286-23294 VB denotes expected
T15523 23294-23295 -COMMA- denotes ,
T15524 23296-23300 NN denotes IKKβ
T15525 23301-23315 VB denotes phosphorylated
T15526 23316-23320 NN denotes RPS3
T15527 23321-23322 -LRB- denotes (
T15528 23322-23326 NNP denotes Fig.
T15529 23327-23329 NNP denotes 7e
T15530 23329-23330 -COMMA- denotes ,
T15531 23331-23335 NN denotes lane
T15532 23336-23337 CD denotes 7
T15533 23337-23338 -RRB- denotes )
T15534 23339-23342 CC denotes and
T15535 23343-23351 NN denotes GST-IκBα
T15536 23352-23353 -LRB- denotes (
T15537 23353-23357 CD denotes 1-54
T15538 23357-23358 -RRB- denotes )
T15539 23359-23366 NN denotes protein
T15540 23367-23368 -LRB- denotes (
T15541 23368-23372 NNP denotes Fig.
T15542 23373-23375 NNP denotes 7e
T15543 23375-23376 -COMMA- denotes ,
T15544 23377-23381 NN denotes lane
T15545 23382-23383 CD denotes 9
T15546 23383-23384 -RRB- denotes )
T15547 23384-23385 -COMMA- denotes ,
T15548 23386-23399 VB denotes demonstrating
T15549 23400-23402 PRP denotes it
T15550 23403-23410 VB denotes harbors
T15551 23411-23417 CC denotes either
T15552 23418-23421 NN denotes CK2
T15553 23422-23424 CC denotes or
T15554 23425-23428 NN denotes IKK
T15555 23429-23438 NN denotes substrate
T15556 23439-23450 NN denotes specificity
T15557 23452-23465 NN denotes Preincubation
T15558 23466-23468 IN denotes of
T15559 23469-23473 NN denotes IKKβ
T15560 23474-23478 IN denotes with
T15561 23479-23484 NN denotes NleH1
T15562 23485-23492 VB denotes reduced
T15563 23493-23506 JJ denotes IKKβ-mediated
T15564 23507-23511 NN denotes RPS3
T15565 23512-23527 NN denotes phosphorylation
T15566 23527-23528 -COMMA- denotes ,
T15567 23529-23533 FW denotes i.e.
T15568 23534-23537 DT denotes the
T15569 23538-23541 NN denotes CK2
T15570 23542-23548 NN denotes kinase
T15571 23549-23560 NN denotes specificity
T15572 23560-23561 -COMMA- denotes ,
T15573 23562-23565 CC denotes but
T15574 23566-23569 RB denotes not
T15575 23570-23583 JJ denotes IKKβ-mediated
T15576 23584-23592 NN denotes GST-IκBα
T15577 23593-23608 NN denotes phosphorylation
T15578 23608-23609 -COMMA- denotes ,
T15579 23610-23614 FW denotes i.e.
T15580 23615-23618 DT denotes the
T15581 23619-23622 NN denotes IKK
T15582 23623-23629 NN denotes kinase
T15583 23630-23641 NN denotes specificity
T15584 23642-23643 -LRB- denotes (
T15585 23643-23647 NNP denotes Fig.
T15586 23648-23650 NNP denotes 7e
T15587 23650-23651 -RRB- denotes )
T15588 23653-23660 NN denotes Control
T15589 23661-23672 NN denotes experiments
T15590 23673-23681 VB denotes revealed
T15591 23682-23684 DT denotes no
T15592 23685-23699 JJ denotes NleH1-mediated
T15593 23700-23715 NN denotes phosphorylation
T15594 23716-23718 CC denotes or
T15595 23719-23738 NN denotes autophosphorylation
T15596 23739-23741 IN denotes of
T15597 23742-23746 NN denotes RPS3
T15598 23747-23749 CC denotes or
T15599 23750-23758 NN denotes GST-IκBα
T15600 23759-23760 -LRB- denotes (
T15601 23760-23764 NNP denotes Fig.
T15602 23765-23767 NNP denotes 7e
T15603 23767-23768 -RRB- denotes )
T15604 23770-23775 VB denotes Taken
T15605 23776-23784 RB denotes together
T15606 23784-23785 -COMMA- denotes ,
T15607 23786-23791 NN denotes NleH1
T15608 23792-23798 VB denotes blocks
T15609 23799-23802 DT denotes the
T15610 23803-23806 NN denotes CK2
T15611 23807-23816 NN denotes substrate
T15612 23817-23828 NN denotes specificity
T15613 23829-23831 IN denotes of
T15614 23832-23836 NN denotes IKKβ
T15615 23837-23841 RB denotes thus
T15616 23842-23852 VB denotes inhibiting
T15617 23853-23856 DT denotes the
T15618 23857-23870 JJ denotes IKKβ-mediated
T15619 23871-23875 NN denotes RPS3
T15620 23876-23880 NN denotes S209
T15621 23881-23896 NN denotes phosphorylation
T15622 23897-23901 RB denotes thus
T15623 23902-23914 VB denotes representing
T15624 23915-23916 DT denotes a
T15625 23917-23922 JJ denotes novel
T15626 23923-23931 NN denotes strategy
T15627 23932-23934 IN denotes by
T15628 23935-23937 FW denotes E.
T15629 23938-23942 FW denotes coli
T15630 23943-23947 NN denotes O157
T15631 23947-23948 -COLON- denotes :
T15632 23948-23950 NN denotes H7
T15633 23951-23953 TO denotes to
T15634 23954-23959 VB denotes alter
T15635 23960-23963 DT denotes the
T15636 23964-23968 NN denotes host
T15637 23969-23975 JJ denotes innate
T15638 23976-23982 JJ denotes immune
T15639 23983-23991 NN denotes response
T18146 24005-24009 NN denotes RPS3
T18148 24014-24024 RB denotes previously
T18149 24025-24037 VB denotes demonstrated
T18150 24038-24040 TO denotes to
T18151 24041-24049 VB denotes function
T18152 24050-24052 IN denotes as
T18153 24053-24055 DT denotes an
T18154 24056-24064 JJ denotes integral
T18155 24065-24072 NN denotes subunit
T18156 24073-24083 VB denotes conferring
T18157 24084-24089 NN denotes NF-κB
T18158 24090-24100 JJ denotes regulatory
T18159 24101-24113 NN denotes specificity6
T18160 24115-24119 RB denotes Here
T18161 24120-24122 PRP denotes we
T18162 24123-24129 VB denotes sought
T18163 24130-24132 TO denotes to
T18164 24133-24142 VB denotes elucidate
T18165 24143-24146 WRB denotes how
T18166 24147-24152 NN denotes NF-κB
T18167 24153-24163 NN denotes activation
T18168 24164-24173 NN denotes signaling
T18169 24174-24182 VB denotes triggers
T18170 24183-24187 NN denotes RPS3
T18171 24188-24190 TO denotes to
T18172 24191-24202 VB denotes translocate
T18173 24203-24206 CC denotes and
T18174 24207-24218 VB denotes participate
T18175 24219-24221 IN denotes in
T18176 24222-24227 NN denotes NF-κB
T18177 24228-24236 NN denotes function
T18178 24237-24239 IN denotes in
T18179 24240-24243 DT denotes the
T18180 24244-24251 NN denotes nucleus
T18181 24253-24255 PRP denotes We
T18182 24256-24267 VB denotes demonstrate
T18183 24268-24272 IN denotes that
T18184 24273-24286 JJ denotes IKKβ-mediated
T18185 24287-24291 NN denotes RPS3
T18186 24292-24296 NN denotes S209
T18187 24297-24312 NN denotes phosphorylation
T18188 24313-24323 VB denotes represents
T18189 24324-24325 DT denotes a
T18190 24326-24334 JJ denotes critical
T18191 24335-24346 NN denotes determinant
T18192 24347-24349 IN denotes in
T18193 24350-24359 VB denotes governing
T18194 24360-24363 PRP-DOLLAR- denotes its
T18195 24364-24371 JJ denotes nuclear
T18196 24372-24378 NN denotes import
T18197 24379-24383 RB denotes thus
T18198 24384-24393 VB denotes unveiling
T18199 24394-24395 DT denotes a
T18200 24396-24401 JJ denotes novel
T18201 24402-24411 NN denotes mechanism
T18202 24412-24418 IN denotes behind
T18203 24419-24424 NN denotes NF-κB
T18204 24425-24435 JJ denotes regulatory
T18205 24436-24447 NN denotes specificity
T18206 24449-24453 NN denotes IKKβ
T18207 24454-24456 VB denotes is
T18208 24457-24460 DT denotes the
T18209 24461-24466 JJ denotes major
T18210 24467-24473 NN denotes kinase
T18211 24474-24478 WDT denotes that
T18212 24479-24493 VB denotes phosphorylates
T18213 24494-24498 NN denotes IκBs
T18214 24499-24501 IN denotes in
T18215 24502-24505 DT denotes the
T18216 24506-24515 JJ denotes classical
T18217 24516-24521 NN denotes NF-κB
T18218 24522-24529 NN denotes pathway
T18219 24529-24530 -COMMA- denotes ,
T18220 24531-24538 VB denotes leading
T18221 24539-24541 TO denotes to
T18222 24542-24547 PRP-DOLLAR- denotes their
T18223 24548-24558 JJ denotes subsequent
T18224 24559-24572 NN denotes degradation40
T18225 24574-24584 RB denotes Strikingly
T18226 24584-24585 -COMMA- denotes ,
T18227 24586-24590 NN denotes RPS3
T18228 24591-24600 VB denotes possesses
T18229 24601-24604 RB denotes not
T18230 24605-24608 DT denotes any
T18231 24609-24618 NN denotes consensus
T18232 24619-24622 NN denotes IKK
T18233 24623-24628 NN denotes motif
T18234 24628-24629 -COLON- denotes ;
T18235 24630-24637 RB denotes instead
T18236 24637-24638 -COMMA- denotes ,
T18237 24639-24643 NN denotes S209
T18238 24644-24646 VB denotes is
T18239 24647-24655 VB denotes centered
T18240 24656-24658 IN denotes in
T18241 24659-24660 DT denotes a
T18242 24661-24670 NN denotes consensus
T18243 24671-24674 NN denotes CK2
T18244 24675-24680 NN denotes motif
T18245 24682-24685 DT denotes The
T18246 24686-24692 JJ denotes recent
T18247 24693-24704 NN denotes observation
T18248 24705-24709 IN denotes that
T18249 24710-24715 JJ denotes human
T18250 24716-24720 NN denotes IKKβ
T18251 24721-24730 VB denotes displayed
T18252 24731-24739 JJ denotes CK2-like
T18253 24740-24755 NN denotes phosphorylation
T18254 24756-24769 NN denotes specificity29
T18255 24770-24779 NN denotes coincides
T18256 24780-24784 IN denotes with
T18257 24785-24788 PRP-DOLLAR- denotes our
T18258 24789-24797 NN denotes evidence
T18259 24798-24802 IN denotes that
T18260 24803-24814 JJ denotes recombinant
T18261 24815-24819 NN denotes IKKβ
T18262 24819-24820 -COMMA- denotes ,
T18263 24821-24824 CC denotes but
T18264 24825-24828 RB denotes not
T18265 24829-24833 NN denotes IKKα
T18266 24833-24834 -COMMA- denotes ,
T18267 24835-24849 VB denotes phosphorylated
T18268 24850-24854 NN denotes RPS3
T18269 24856-24858 PRP denotes We
T18270 24859-24864 VB denotes found
T18271 24865-24869 DT denotes this
T18272 24870-24885 NN denotes phosphorylation
T18273 24886-24888 VB denotes is
T18274 24889-24890 DT denotes a
T18275 24891-24899 JJ denotes critical
T18276 24900-24910 NN denotes modulation
T18277 24911-24914 IN denotes for
T18278 24915-24919 NN denotes RPS3
T18279 24920-24927 JJ denotes nuclear
T18280 24928-24941 NN denotes translocation
T18281 24942-24943 -LRB- denotes (
T18282 24943-24946 IN denotes via
T18283 24947-24957 NN denotes importin-α
T18284 24957-24958 -RRB- denotes )
T18285 24959-24962 CC denotes and
T18286 24963-24973 NN denotes engagement
T18287 24974-24976 IN denotes in
T18288 24977-24985 JJ denotes specific
T18289 24986-24991 NN denotes NF-κB
T18290 24992-25005 NN denotes transcription
T18291 25007-25010 NN denotes CK2
T18292 25011-25014 VB denotes was
T18293 25015-25025 RB denotes previously
T18294 25026-25031 VB denotes shown
T18295 25032-25034 TO denotes to
T18296 25035-25048 VB denotes phosphorylate
T18297 25049-25052 NN denotes p65
T18298 25053-25056 CC denotes and
T18299 25057-25059 TO denotes to
T18300 25060-25064 VB denotes bind
T18301 25065-25067 TO denotes to
T18302 25068-25071 CC denotes and
T18303 25072-25085 VB denotes phosphorylate
T18304 25086-25095 NN denotes IKKβ41-43
T18305 25095-25096 -COMMA- denotes ,
T18306 25097-25104 RB denotes however
T18307 25104-25105 -COMMA- denotes ,
T18308 25106-25108 PRP denotes we
T18309 25109-25114 VB denotes ruled
T18310 25115-25118 RP denotes out
T18311 25119-25122 DT denotes the
T18312 25123-25134 NN denotes possibility
T18313 25135-25139 IN denotes that
T18314 25140-25143 DT denotes the
T18315 25144-25154 JJ denotes IKKβ-bound
T18316 25155-25158 NN denotes CK2
T18317 25159-25164 MD denotes could
T18318 25165-25172 VB denotes account
T18319 25173-25176 IN denotes for
T18320 25177-25180 DT denotes the
T18321 25181-25189 VB denotes observed
T18322 25190-25194 NN denotes RPS3
T18323 25195-25210 NN denotes phosphorylation
T18324 25211-25218 IN denotes because
T18325 25219-25221 DT denotes no
T18326 25222-25225 NN denotes CK2
T18327 25226-25229 VB denotes was
T18328 25230-25238 VB denotes detected
T18329 25239-25241 IN denotes in
T18330 25242-25245 DT denotes the
T18331 25246-25250 NN denotes IKKβ
T18332 25251-25263 NN denotes preparations
T18333 25264-25268 VB denotes used
T18334 25269-25272 IN denotes for
T18335 25273-25276 DT denotes the
T18336 25277-25279 FW denotes in
T18337 25280-25285 FW denotes vitro
T18338 25286-25292 NN denotes kinase
T18339 25293-25298 NN denotes assay
T18340 25300-25307 IN denotes Because
T18341 25308-25312 NN denotes RPS3
T18342 25313-25317 RB denotes only
T18343 25318-25325 VB denotes harbors
T18344 25326-25329 DT denotes the
T18345 25330-25333 NN denotes CK2
T18346 25334-25339 NN denotes motif
T18347 25340-25343 CC denotes and
T18348 25344-25347 RB denotes not
T18349 25348-25349 DT denotes a
T18350 25350-25361 JJ denotes traditional
T18351 25362-25365 NN denotes IKK
T18352 25366-25371 NN denotes motif
T18353 25371-25372 -COMMA- denotes ,
T18354 25373-25377 DT denotes this
T18355 25378-25382 NN denotes RPS3
T18356 25383-25393 JJ denotes regulatory
T18357 25394-25402 NN denotes function
T18358 25403-25408 MD denotes could
T18359 25409-25416 VB denotes explain
T18360 25417-25420 WRB denotes why
T18361 25421-25424 NN denotes IKK
T18362 25425-25432 VB denotes harbors
T18363 25433-25436 DT denotes the
T18364 25437-25448 JJ denotes alternative
T18365 25449-25458 NN denotes substrate
T18366 25459-25474 NN denotes phosphorylation
T18367 25475-25485 NN denotes capability
T18368 25487-25491 RB denotes More
T18369 25492-25503 RB denotes importantly
T18370 25503-25504 -COMMA- denotes ,
T18371 25505-25508 PRP-DOLLAR- denotes our
T18372 25509-25514 NN denotes study
T18373 25515-25518 VB denotes has
T18374 25519-25529 VB denotes elucidated
T18375 25530-25533 WRB denotes how
T18376 25534-25538 NN denotes RPS3
T18377 25539-25541 VB denotes is
T18378 25542-25555 RB denotes biochemically
T18379 25556-25566 VB denotes integrated
T18380 25567-25571 IN denotes into
T18381 25572-25577 NN denotes NF-κB
T18382 25578-25588 NN denotes activation
T18383 25589-25598 NN denotes signaling
T18384 25599-25601 IN denotes in
T18385 25602-25603 DT denotes a
T18386 25604-25610 NN denotes manner
T18387 25611-25615 WDT denotes that
T18388 25616-25618 VB denotes is
T18389 25619-25626 JJ denotes pivotal
T18390 25627-25630 IN denotes for
T18391 25631-25634 DT denotes the
T18392 25635-25647 NN denotes pathogenesis
T18393 25648-25650 IN denotes of
T18394 25651-25660 JJ denotes foodborne
T18395 25661-25669 NN denotes pathogen
T18396 25670-25672 FW denotes E.
T18397 25673-25677 FW denotes coli
T18398 25678-25682 NN denotes O157
T18399 25682-25683 -COLON- denotes :
T18400 25683-25685 NN denotes H7
T18401 25687-25700 JJ denotes IKKβ-mediated
T18402 25701-25705 NN denotes RPS3
T18403 25706-25710 NN denotes S209
T18404 25711-25726 NN denotes phosphorylation
T18405 25727-25729 VB denotes is
T18406 25730-25731 DT denotes a
T18407 25732-25740 JJ denotes critical
T18408 25741-25747 NN denotes target
T18409 25748-25757 VB denotes modulated
T18410 25758-25760 IN denotes by
T18411 25761-25765 DT denotes this
T18412 25766-25774 NN denotes pathogen
T18413 25775-25777 TO denotes to
T18414 25778-25785 VB denotes subvert
T18415 25786-25790 NN denotes host
T18416 25791-25796 NN denotes NF-κB
T18417 25797-25806 NN denotes signaling
T18418 25808-25811 DT denotes The
T18419 25812-25821 JJ denotes bacterial
T18420 25822-25830 NN denotes effector
T18421 25831-25836 NN denotes NleH1
T18422 25837-25849 RB denotes specifically
T18423 25850-25855 VB denotes binds
T18424 25856-25858 TO denotes to
T18425 25859-25863 NN denotes RPS3
T18426 25864-25868 RB denotes once
T18427 25869-25877 VB denotes injected
T18428 25878-25882 IN denotes into
T18429 25883-25887 NN denotes host
T18430 25888-25893 NN denotes cells
T18431 25894-25897 CC denotes and
T18432 25898-25908 RB denotes profoundly
T18433 25909-25919 VB denotes suppresses
T18434 25920-25925 NN denotes NF-κB
T18435 25926-25929 CC denotes and
T18436 25930-25933 PRP-DOLLAR- denotes its
T18437 25934-25943 JJ denotes attendant
T18439 25955-25961 JJ denotes immune
T18440 25962-25972 NN denotes responses9
T18441 25974-25977 PRP-DOLLAR- denotes Our
T18442 25978-25982 NN denotes data
T18443 25983-25986 RB denotes now
T18444 25987-25991 VB denotes show
T18445 25992-25996 IN denotes that
T18446 25997-26002 NN denotes NleH1
T18447 26003-26014 RB denotes selectively
T18448 26015-26023 VB denotes inhibits
T18449 26024-26028 NN denotes RPS3
T18450 26029-26044 NN denotes phosphorylation
T18451 26044-26045 -COMMA- denotes ,
T18452 26046-26050 RB denotes thus
T18453 26051-26060 VB denotes retarding
T18454 26061-26064 PRP-DOLLAR- denotes its
T18455 26065-26072 JJ denotes nuclear
T18456 26073-26086 NN denotes translocation
T18457 26087-26090 CC denotes and
T18458 26091-26101 JJ denotes subsequent
T18459 26102-26107 NN denotes NF-κB
T18460 26108-26116 NN denotes function
T18461 26116-26117 -COMMA- denotes ,
T18462 26118-26125 IN denotes without
T18463 26126-26134 VB denotes altering
T18464 26135-26140 JJ denotes other
T18465 26141-26146 NN denotes NF-κB
T18466 26147-26156 NN denotes signaling
T18467 26158-26166 IN denotes Although
T18468 26167-26172 NN denotes NleH1
T18469 26173-26176 VB denotes did
T18470 26177-26180 RB denotes not
T18471 26181-26189 RB denotes directly
T18472 26190-26203 VB denotes phosphorylate
T18473 26204-26208 NN denotes IKKβ
T18474 26208-26209 -COMMA- denotes ,
T18475 26210-26213 PRP-DOLLAR- denotes its
T18476 26214-26220 NN denotes kinase
T18477 26221-26229 NN denotes activity
T18478 26230-26233 VB denotes was
T18479 26234-26242 VB denotes required
T18480 26243-26245 TO denotes to
T18481 26246-26253 VB denotes inhibit
T18482 26254-26267 JJ denotes IKKβ-mediated
T18483 26268-26272 NN denotes RPS3
T18484 26273-26277 NN denotes S209
T18485 26278-26293 NN denotes phosphorylation
T18486 26295-26299 JJ denotes Many
T18487 26300-26308 NN denotes bacteria
T18488 26309-26318 NN denotes pathogens
T18489 26319-26323 VB denotes have
T18490 26324-26332 NN denotes products
T18491 26333-26337 WDT denotes that
T18492 26338-26344 VB denotes target
T18493 26345-26348 JJ denotes key
T18494 26349-26356 NN denotes kinases
T18495 26357-26359 TO denotes to
T18496 26360-26370 VB denotes inactivate
T18497 26371-26375 PRP denotes them
T18498 26376-26378 IN denotes in
T18499 26379-26383 NN denotes host
T18500 26384-26389 NN denotes cells
T18501 26389-26390 -COMMA- denotes ,
T18502 26391-26398 IN denotes whereas
T18503 26399-26401 FW denotes E.
T18504 26402-26406 FW denotes coli
T18505 26407-26411 NN denotes O157
T18506 26411-26412 -COLON- denotes :
T18507 26412-26414 NN denotes H7
T18508 26415-26423 VB denotes employed
T18509 26424-26429 NN denotes NleH1
T18510 26430-26432 TO denotes to
T18511 26433-26438 VB denotes steer
T18512 26439-26442 DT denotes the
T18513 26443-26452 NN denotes substrate
T18514 26453-26464 NN denotes specificity
T18515 26465-26467 IN denotes of
T18516 26468-26472 NN denotes IKKβ
T18517 26473-26477 RB denotes thus
T18518 26478-26490 RB denotes specifically
T18519 26491-26502 JJ denotes fine-tuning
T18520 26503-26507 NN denotes host
T18521 26508-26513 NN denotes NF-κB
T18522 26514-26523 NN denotes signaling
T18523 26525-26529 DT denotes This
T18524 26530-26535 MD denotes could
T18525 26536-26545 VB denotes represent
T18526 26546-26547 DT denotes a
T18527 26548-26553 JJ denotes novel
T18528 26554-26562 NN denotes strategy
T18529 26563-26565 TO denotes to
T18530 26566-26575 VB denotes fine-tune
T18531 26576-26580 NN denotes host
T18532 26581-26586 NN denotes NF-κB
T18533 26587-26596 NN denotes signaling
T18534 26597-26601 WDT denotes that
T18535 26602-26607 MD denotes could
T18536 26608-26610 VB denotes be
T18537 26611-26617 VB denotes shared
T18538 26618-26620 IN denotes by
T18539 26621-26626 JJ denotes other
T18540 26627-26636 NN denotes pathogens
T18541 26638-26643 DT denotes These
T18542 26644-26648 NN denotes data
T18543 26649-26656 VB denotes provide
T18544 26657-26660 JJ denotes new
T18545 26661-26669 NN denotes insights
T18546 26670-26674 IN denotes into
T18547 26675-26678 DT denotes the
T18548 26679-26685 RB denotes poorly
T18549 26686-26696 VB denotes understood
T18550 26697-26703 NN denotes action
T18551 26704-26713 NN denotes mechanism
T18552 26714-26717 IN denotes for
T18553 26718-26722 JJ denotes most
T18554 26723-26727 NN denotes T3SS
T18555 26728-26737 NN denotes effectors
T18556 26739-26744 NN denotes NleH1
T18557 26745-26755 VB denotes attenuates
T18558 26756-26759 DT denotes the
T18559 26760-26773 NN denotes transcription
T18560 26774-26776 IN denotes of
T18561 26777-26791 JJ denotes RPS3-dependent
T18562 26791-26792 -COMMA- denotes ,
T18563 26793-26796 CC denotes but
T18564 26797-26800 RB denotes not
T18565 26801-26804 DT denotes all
T18566 26804-26805 -COMMA- denotes ,
T18567 26806-26811 NN denotes NF-κB
T18568 26812-26818 NN denotes target
T18569 26819-26824 NN denotes genes
T18570 26824-26825 -COMMA- denotes ,
T18571 26826-26828 IN denotes in
T18572 26829-26839 JJ denotes particular
T18573 26840-26845 DT denotes those
T18574 26846-26851 NN denotes genes
T18575 26852-26862 VB denotes associated
T18576 26863-26867 IN denotes with
T18577 26868-26873 JJ denotes acute
T18578 26874-26889 JJ denotes proinflammatory
T18579 26890-26899 NN denotes responses
T18580 26899-26900 -COMMA- denotes ,
T18581 26901-26910 VB denotes including
T18582 26911-26914 NN denotes IL8
T18583 26915-26918 CC denotes and
T18584 26919-26922 NN denotes TNF
T18585 26924-26926 IN denotes In
T18586 26927-26935 NN denotes contrast
T18587 26935-26936 -COMMA- denotes ,
T18588 26937-26942 NN denotes NleH1
T18589 26943-26947 VB denotes does
T18590 26948-26951 RB denotes not
T18591 26952-26957 VB denotes block
T18592 26958-26963 NN denotes NF-κB
T18593 26964-26967 NN denotes p65
T18594 26968-26975 JJ denotes nuclear
T18595 26976-26989 NN denotes translocation
T18596 26989-26990 -COMMA- denotes ,
T18597 26991-26996 WDT denotes which
T18598 26997-27005 VB denotes suggests
T18599 27006-27010 IN denotes that
T18600 27011-27018 JJ denotes certain
T18601 27019-27032 JJ denotes p65-dependent
T18602 27033-27036 CC denotes but
T18603 27037-27053 JJ denotes RPS3-independent
T18604 27054-27059 NN denotes NF-κB
T18605 27060-27066 NN denotes target
T18606 27067-27072 NN denotes genes
T18607 27073-27078 MD denotes might
T18608 27079-27083 RB denotes thus
T18609 27084-27086 VB denotes be
T18610 27087-27097 JJ denotes beneficial
T18611 27098-27101 IN denotes for
T18612 27102-27104 FW denotes E.
T18613 27105-27109 FW denotes coli
T18614 27110-27114 NN denotes O157
T18615 27114-27115 -COLON- denotes :
T18616 27115-27117 NN denotes H7
T18617 27118-27120 TO denotes to
T18618 27121-27130 VB denotes replicate
T18619 27131-27134 CC denotes and
T18620 27135-27146 VB denotes disseminate
T18621 27147-27149 IN denotes in
T18622 27150-27153 DT denotes the
T18623 27154-27158 NN denotes host
T18624 27160-27162 IN denotes By
T18625 27163-27174 RB denotes selectively
T18626 27175-27185 VB denotes inhibiting
T18627 27186-27190 NN denotes RPS3
T18628 27191-27194 CC denotes and
T18629 27195-27198 PRP-DOLLAR- denotes its
T18630 27199-27208 JJ denotes attendant
T18631 27209-27214 NN denotes NF-κB
T18632 27215-27223 NN denotes function
T18633 27224-27228 IN denotes with
T18634 27229-27234 NN denotes NleH1
T18635 27234-27235 -COMMA- denotes ,
T18636 27236-27239 DT denotes the
T18637 27240-27248 NN denotes pathogen
T18638 27249-27257 VB denotes achieves
T18639 27258-27261 DT denotes the
T18640 27262-27269 NN denotes ability
T18641 27270-27272 TO denotes to
T18642 27273-27281 VB denotes increase
T18643 27282-27294 NN denotes colonization
T18644 27295-27298 CC denotes and
T18645 27299-27307 NN denotes diarrhea
T18646 27308-27311 RB denotes yet
T18647 27312-27320 VB denotes limiting
T18648 27321-27324 DT denotes the
T18649 27325-27334 NN denotes mortality
T18650 27335-27337 IN denotes of
T18651 27338-27341 DT denotes the
T18652 27342-27346 NN denotes host
T18653 27348-27352 DT denotes This
T18654 27353-27362 RB denotes seemingly
T18655 27363-27374 JJ denotes paradoxical
T18656 27375-27386 NN denotes combination
T18657 27387-27389 IN denotes of
T18658 27390-27397 NN denotes effects
T18659 27398-27402 VB denotes make
T18660 27403-27408 NN denotes sense
T18661 27409-27413 WRB denotes when
T18662 27414-27417 CD denotes one
T18663 27418-27427 VB denotes considers
T18664 27428-27432 IN denotes that
T18665 27433-27442 VB denotes increased
T18666 27443-27452 JJ denotes bacterial
T18667 27453-27457 NN denotes load
T18668 27458-27461 CC denotes and
T18669 27462-27470 NN denotes diarrhea
T18670 27471-27479 RB denotes together
T18671 27480-27484 IN denotes with
T18672 27485-27493 NN denotes survival
T18673 27494-27496 IN denotes of
T18674 27497-27500 DT denotes the
T18675 27501-27509 JJ denotes infected
T18676 27510-27514 NN denotes host
T18677 27515-27520 MD denotes would
T18678 27521-27528 VB denotes promote
T18679 27529-27532 DT denotes the
T18680 27533-27542 NN denotes spreading
T18681 27543-27545 IN denotes of
T18682 27546-27549 DT denotes the
T18683 27550-27558 NN denotes bacteria
T18684 27559-27564 IN denotes among
T18685 27565-27566 DT denotes a
T18686 27567-27577 NN denotes population
T18687 27578-27580 IN denotes of
T18688 27581-27592 JJ denotes susceptible
T18689 27593-27604 NN denotes individuals
T18690 27606-27610 JJ denotes Such
T18691 27611-27618 NN denotes complex
T18692 27619-27622 CC denotes and
T18693 27623-27634 JJ denotes paradoxical
T18694 27635-27647 JJ denotes pathological
T18695 27648-27655 NN denotes effects
T18696 27656-27660 WDT denotes that
T18697 27661-27670 VB denotes influence
T18698 27671-27674 DT denotes the
T18699 27675-27681 NN denotes spread
T18700 27682-27684 IN denotes of
T18701 27685-27692 NN denotes disease
T18702 27693-27696 VB denotes are
T18703 27697-27702 RB denotes often
T18704 27703-27709 RB denotes poorly
T18705 27710-27720 VB denotes understood
T18706 27721-27723 IN denotes at
T18707 27724-27727 DT denotes the
T18708 27728-27737 JJ denotes molecular
T18709 27738-27743 NN denotes level
T18710 27745-27748 PRP-DOLLAR- denotes Our
T18711 27749-27753 NN denotes data
T18712 27754-27763 VB denotes elucidate
T18713 27764-27767 WRB denotes how
T18714 27768-27779 NN denotes alterations
T18715 27780-27782 IN denotes in
T18716 27783-27792 JJ denotes selective
T18717 27793-27798 NN denotes NF-κB
T18718 27799-27807 NN denotes function
T18719 27807-27808 -COMMA- denotes ,
T18720 27809-27817 VB denotes achieved
T18721 27818-27820 IN denotes by
T18722 27821-27829 VB denotes impeding
T18723 27830-27834 NN denotes RPS3
T18724 27834-27835 -COMMA- denotes ,
T18725 27836-27839 CC denotes but
T18726 27840-27843 RB denotes not
T18727 27844-27852 VB denotes altering
T18728 27853-27856 NN denotes p65
T18729 27857-27864 JJ denotes nuclear
T18730 27865-27878 NN denotes translocation
T18731 27878-27879 -COMMA- denotes ,
T18732 27880-27883 MD denotes can
T18733 27884-27893 VB denotes influence
T18734 27894-27902 JJ denotes specific
T18735 27903-27912 NN denotes cytokines
T18736 27913-27917 WDT denotes that
T18737 27918-27924 VB denotes affect
T18738 27925-27934 JJ denotes bacterial
T18739 27935-27947 NN denotes colonization
T18740 27947-27948 -COMMA- denotes ,
T18741 27949-27957 NN denotes diarrhea
T18742 27958-27966 NN denotes diseases
T18743 27967-27970 CC denotes and
T18744 27971-27980 NN denotes mortality
T18745 27982-27984 PRP denotes It
T18746 27985-27988 MD denotes may
T18747 27989-27991 VB denotes be
T18748 27992-28000 JJ denotes fruitful
T18749 28001-28003 IN denotes in
T18750 28004-28014 VB denotes attempting
T18751 28015-28017 TO denotes to
T18752 28018-28028 VB denotes understand
T18753 28029-28034 JJ denotes other
T18754 28035-28045 JJ denotes infectious
T18755 28046-28049 CC denotes and
T18756 28050-28060 JJ denotes autoimmune
T18757 28061-28069 NN denotes diseases
T18758 28070-28079 VB denotes involving
T18759 28080-28085 NN denotes NF-κB
T18760 28086-28088 TO denotes to
T18761 28089-28097 VB denotes consider
T18762 28098-28107 JJ denotes selective
T18763 28108-28115 NN denotes effects
T18764 28116-28118 IN denotes of
T18765 28119-28127 NN denotes subunits
T18766 28128-28132 JJ denotes such
T18767 28133-28135 IN denotes as
T18768 28136-28140 NN denotes RPS3
T18769 28141-28143 IN denotes in
T18770 28144-28152 NN denotes addition
T18771 28153-28155 TO denotes to
T18772 28156-28162 JJ denotes global
T18773 28163-28168 NN denotes NF-κB
T18774 28169-28179 NN denotes inhibition
T20521 29298-29305 NN denotes Plasmid
T20522 29306-29316 NN denotes Constructs
T20523 29317-29320 DT denotes The
T20524 29321-29330 NN denotes Flag-IKKβ
T20525 29331-29332 -LRB- denotes (
T20526 29332-29336 NN denotes SSEE
T20527 29336-29337 -RRB- denotes )
T20528 29337-29338 -COMMA- denotes ,
T20529 29339-29348 NN denotes Flag-IKKβ
T20530 29349-29350 -LRB- denotes (
T20531 29350-29354 NN denotes SSAA
T20532 29354-29355 -RRB- denotes )
T20533 29355-29356 -COMMA- denotes ,
T20534 29357-29360 CC denotes and
T20535 29361-29368 NN denotes HA-IκBα
T20536 29369-29370 -LRB- denotes (
T20537 29370-29374 NN denotes SSAA
T20538 29374-29375 -RRB- denotes )
T20539 29376-29386 NN denotes constructs
T20540 29387-29391 VB denotes were
T20541 29392-29400 VB denotes provided
T20542 29401-29403 IN denotes by
T20543 29404-29406 NNP denotes C.
T20544 29407-29409 NNP denotes Wu
T20545 29410-29411 -LRB- denotes (
T20546 29411-29414 NNP denotes NCI
T20547 29414-29415 -COMMA- denotes ,
T20548 29416-29424 NNP denotes Bethesda
T20549 29424-29425 -RRB- denotes )
T20550 29426-29429 CC denotes and
T20551 29430-29432 NNP denotes U.
T20552 29433-29443 NNP denotes Siebenlist
T20553 29444-29445 -LRB- denotes (
T20554 29445-29450 NNP denotes NIAID
T20555 29450-29451 -COMMA- denotes ,
T20556 29452-29460 NNP denotes Bethesda
T20557 29460-29461 -RRB- denotes )
T20558 29461-29462 -COMMA- denotes ,
T20559 29463-29475 RB denotes respectively
T20560 29477-29480 DT denotes The
T20561 29481-29488 NN denotes HA-IκBα
T20562 29489-29492 CC denotes and
T20563 29493-29497 NN denotes IKKβ
T20564 29498-29499 -LRB- denotes (
T20565 29499-29503 NN denotes K44A
T20566 29503-29504 -RRB- denotes )
T20567 29504-29509 NN denotes -Flag
T20568 29510-29518 NN denotes plasmids
T20569 29519-29523 VB denotes were
T20570 29524-29533 VB denotes purchased
T20571 29534-29538 IN denotes from
T20572 29539-29548 NN denotes Addgene44
T20573 29548-29549 -COMMA- denotes ,
T20574 29550-29552 CD denotes 45
T20575 29554-29557 DT denotes The
T20576 29558-29567 NN denotes Flag-RPS3
T20577 29567-29568 -COMMA- denotes ,
T20578 29569-29577 NN denotes GST-RPS3
T20579 29577-29578 -COMMA- denotes ,
T20580 29579-29586 NN denotes HA-RPS3
T20581 29586-29587 -COMMA- denotes ,
T20582 29588-29593 NN denotes VN-HA
T20583 29593-29594 -COMMA- denotes ,
T20584 29595-29603 NN denotes NleH1-HA
T20585 29604-29612 NN denotes plasmids
T20586 29613-29617 VB denotes were
T20587 29618-29627 VB denotes described
T20588 29628-29639 NN denotes previously6
T20589 29639-29640 -COMMA- denotes ,
T20590 29641-29642 CD denotes 9
T20591 29644-29647 DT denotes The
T20592 29648-29653 NN denotes point
T20593 29654-29661 NN denotes mutants
T20594 29662-29664 IN denotes of
T20595 29665-29669 NN denotes RPS3
T20596 29670-29674 VB denotes were
T20597 29675-29684 VB denotes generated
T20598 29685-29687 IN denotes by
T20599 29688-29701 JJ denotes site-directed
T20600 29702-29713 NN denotes mutagenesis
T20601 29714-29719 VB denotes using
T20602 29720-29723 DT denotes the
T20603 29724-29729 NNP denotes Quick
T20604 29730-29736 NNP denotes Change
T20605 29737-29740 NN denotes Kit
T20606 29741-29742 -LRB- denotes (
T20607 29742-29752 NN denotes Stratagene
T20608 29752-29753 -RRB- denotes )
T20609 29754-29758 IN denotes with
T20610 29759-29766 NN denotes primers
T20611 29767-29774 RB denotes forward
T20612 29775-29814 JJ denotes 5′-CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3′
T20613 29815-29818 CC denotes and
T20614 29819-29826 JJ denotes reverse
T20615 29827-29866 NN denotes 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′
T20616 29867-29870 IN denotes for
T20617 29871-29876 NN denotes S209A
T20618 29878-29881 DT denotes All
T20619 29882-29889 NN denotes mutants
T20620 29890-29894 VB denotes were
T20621 29895-29903 VB denotes verified
T20622 29904-29906 IN denotes by
T20623 29907-29910 NN denotes DNA
T20624 29911-29921 NN denotes sequencing
T20847 29924-29927 NN denotes 32P
T20848 29928-29930 FW denotes in
T20849 29931-29935 FW denotes vivo
T20850 29936-29944 NN denotes Labeling
T20851 29945-29948 NN denotes HEK
T20852 29949-29953 NN denotes 293T
T20853 29954-29959 NN denotes cells
T20854 29960-29964 VB denotes were
T20855 29965-29972 VB denotes labeled
T20856 29973-29977 IN denotes with
T20857 29978-29979 CD denotes 2
T20858 29980-29986 NN denotes mCi/ml
T20859 29987-30005 NN denotes 32P-orthophosphate
T20860 30006-30007 -LRB- denotes (
T20861 30007-30013 NNP denotes Perkin
T20862 30014-30019 NNP denotes Elmer
T20863 30019-30020 -RRB- denotes )
T20864 30021-30023 IN denotes in
T20865 30024-30038 JJ denotes phosphate-free
T20866 30039-30045 NN denotes medium
T20867 30046-30047 -LRB- denotes (
T20868 30047-30057 NN denotes Invitrogen
T20869 30057-30058 -RRB- denotes )
T20870 30059-30062 IN denotes for
T20871 30063-30064 CD denotes 2
T20872 30065-30066 NN denotes h
T20873 30068-30073 NN denotes Cells
T20874 30074-30078 VB denotes were
T20875 30079-30083 RB denotes then
T20876 30084-30088 VB denotes left
T20877 30089-30098 JJ denotes untreated
T20878 30099-30101 CC denotes or
T20879 30102-30109 VB denotes treated
T20880 30110-30114 IN denotes with
T20881 30115-30118 NN denotes TNF
T20882 30119-30120 -LRB- denotes (
T20883 30120-30122 CD denotes 50
T20884 30123-30128 NN denotes ng/ml
T20885 30128-30129 -COMMA- denotes ,
T20886 30130-30131 NNP denotes R
T20887 30131-30132 CC denotes &
T20888 30132-30133 NNP denotes D
T20889 30134-30141 NNP denotes Systems
T20890 30141-30142 -RRB- denotes )
T20891 30143-30146 IN denotes for
T20892 30147-30156 VB denotes indicated
T20893 30157-30164 NN denotes periods
T20894 30166-30170 NN denotes Cell
T20895 30171-30178 NN denotes lysates
T20896 30179-30183 VB denotes were
T20897 30184-30192 VB denotes prepared
T20898 30193-30196 CC denotes and
T20899 30197-30201 VB denotes used
T20900 30202-30205 IN denotes for
T20901 30206-30226 NN denotes immunoprecipitations
T20902 30227-30231 IN denotes with
T20903 30232-30236 NN denotes RPS3
T20904 30237-30245 NN denotes antibody
T20995 30248-30250 IN denotes In
T20996 30251-30256 NNP denotes Vitro
T20997 30257-30263 NNP denotes Kinase
T20998 30264-30269 NNP denotes Assay
T20999 30270-30283 JJ denotes Kinase-active
T21000 30284-30295 JJ denotes recombinant
T21001 30296-30300 NN denotes IKKβ
T21002 30301-30304 CC denotes and
T21003 30305-30309 NN denotes IKKα
T21004 30310-30318 NN denotes proteins
T21005 30319-30323 VB denotes were
T21006 30324-30333 VB denotes purchased
T21007 30334-30338 IN denotes from
T21008 30339-30345 JJ denotes Active
T21009 30346-30351 NNP denotes Motif
T21010 30352-30355 CC denotes and
T21011 30356-30365 NNP denotes Millipore
T21012 30365-30366 -COMMA- denotes ,
T21013 30367-30379 RB denotes respectively
T21014 30381-30392 RB denotes Bacterially
T21015 30393-30401 VB denotes purified
T21016 30402-30413 NN denotes glutathione
T21017 30414-30427 NN denotes S-transferase
T21018 30428-30429 -LRB- denotes (
T21019 30429-30432 NN denotes GST
T21020 30432-30433 -RRB- denotes )
T21021 30433-30434 -COMMA- denotes ,
T21022 30435-30443 NN denotes GST-IκBα
T21023 30444-30445 -LRB- denotes (
T21024 30445-30449 CD denotes 1-54
T21025 30449-30450 -RRB- denotes )
T21026 30450-30451 -COMMA- denotes ,
T21027 30452-30456 JJ denotes wild
T21028 30457-30461 NN denotes type
T21029 30461-30462 -COMMA- denotes ,
T21030 30463-30469 JJ denotes mutant
T21031 30470-30478 NN denotes GST-RPS3
T21032 30478-30479 -COMMA- denotes ,
T21033 30480-30482 CC denotes or
T21034 30483-30487 NN denotes RPS3
T21035 30488-30496 NN denotes proteins
T21036 30497-30501 VB denotes were
T21037 30502-30506 VB denotes used
T21038 30507-30509 IN denotes as
T21039 30510-30520 NN denotes substrates
T21040 30522-30525 DT denotes The
T21041 30526-30528 FW denotes in
T21042 30529-30534 FW denotes vitro
T21043 30535-30541 NN denotes kinase
T21044 30542-30547 NN denotes assay
T21045 30548-30551 VB denotes was
T21046 30552-30561 VB denotes performed
T21047 30562-30564 IN denotes as
T21048 30565-30575 RB denotes previously
T21049 30576-30587 NN denotes described29
T21050 30589-30596 RB denotes Briefly
T21051 30596-30597 -COMMA- denotes ,
T21052 30598-30604 NN denotes enzyme
T21053 30605-30606 -LRB- denotes (
T21054 30606-30609 CD denotes 100
T21055 30610-30612 NN denotes ng
T21056 30612-30613 -RRB- denotes )
T21057 30614-30617 CC denotes and
T21058 30618-30627 NN denotes substrate
T21059 30628-30629 -LRB- denotes (
T21060 30629-30630 CD denotes 2
T21061 30631-30633 NN denotes μg
T21062 30633-30634 -RRB- denotes )
T21063 30635-30639 VB denotes were
T21064 30640-30652 VB denotes co-incubated
T21065 30653-30655 IN denotes in
T21066 30656-30659 NN denotes IKK
T21067 30660-30668 NN denotes reaction
T21068 30669-30675 NN denotes buffer
T21069 30676-30677 -LRB- denotes (
T21070 30677-30679 CD denotes 25
T21071 30680-30682 NN denotes mM
T21072 30683-30691 NN denotes Tris–HCl
T21073 30692-30693 -LRB- denotes [
T21074 30693-30695 NN denotes pH
T21075 30696-30699 CD denotes 8.0
T21076 30699-30700 -RRB- denotes ]
T21077 30700-30701 -COMMA- denotes ,
T21078 30702-30704 CD denotes 50
T21079 30705-30707 NN denotes mM
T21080 30708-30711 NN denotes KCl
T21081 30711-30712 -COMMA- denotes ,
T21082 30713-30715 CD denotes 10
T21083 30716-30718 NN denotes mM
T21084 30719-30724 NN denotes MgCl2
T21085 30724-30725 -COMMA- denotes ,
T21086 30726-30727 CD denotes 1
T21087 30728-30730 NN denotes mM
T21088 30731-30734 NN denotes DTT
T21089 30734-30735 -COMMA- denotes ,
T21090 30736-30737 CD denotes 1
T21091 30738-30740 NN denotes mM
T21092 30741-30747 NN denotes Na3VO4
T21093 30747-30748 -COMMA- denotes ,
T21094 30749-30750 CD denotes 1
T21095 30751-30753 NN denotes mM
T21096 30754-30757 NN denotes ATP
T21097 30757-30758 -RRB- denotes )
T21098 30759-30761 CC denotes or
T21099 30762-30767 NN denotes NleH1
T21100 30768-30776 NN denotes reaction
T21101 30777-30783 NN denotes buffer
T21102 30784-30785 -LRB- denotes (
T21103 30785-30787 CD denotes 50
T21104 30788-30790 NN denotes mM
T21105 30791-30799 NN denotes Tris-HCl
T21106 30800-30801 -LRB- denotes [
T21107 30801-30803 NN denotes pH
T21108 30804-30807 CD denotes 7.6
T21109 30807-30808 -RRB- denotes ]
T21110 30808-30809 -COMMA- denotes ,
T21111 30810-30811 CD denotes 5
T21112 30812-30814 NN denotes mM
T21113 30815-30820 NN denotes MgCl2
T21114 30820-30821 -COMMA- denotes ,
T21115 30822-30823 CD denotes 1
T21116 30824-30826 NN denotes mM
T21117 30827-30830 NN denotes DTT
T21118 30830-30831 -COMMA- denotes ,
T21119 30832-30833 CD denotes 1
T21120 30834-30836 NN denotes mM
T21121 30837-30840 NN denotes ATP
T21122 30840-30841 -RRB- denotes )
T21123 30842-30846 IN denotes with
T21124 30847-30850 CD denotes 0.5
T21125 30851-30854 NNP denotes μCi
T21126 30855-30864 NN denotes 32P-γ-ATP
T21127 30865-30866 -LRB- denotes (
T21128 30866-30868 NNP denotes GE
T21129 30869-30879 NNP denotes Healthcare
T21130 30879-30880 -RRB- denotes )
T21131 30881-30886 VB denotes added
T21132 30887-30889 IN denotes at
T21133 30890-30892 CD denotes 37
T21134 30893-30895 NN denotes °C
T21135 30896-30899 IN denotes for
T21136 30900-30902 CD denotes 30
T21137 30903-30906 NN denotes min
T21138 30908-30911 DT denotes The
T21139 30912-30921 NN denotes reactions
T21140 30922-30926 VB denotes were
T21141 30927-30935 VB denotes resolved
T21142 30936-30938 IN denotes by
T21143 30939-30947 NN denotes SDS–PAGE
T21144 30948-30951 CC denotes and
T21145 30952-30962 VB denotes visualized
T21146 30963-30965 IN denotes by
T21147 30966-30981 NN denotes autoradiography
T21367 30984-30992 NN denotes LC-MS/MS
T21368 30993-31001 NN denotes Analysis
T21369 31002-31005 NN denotes GST
T21370 31006-31008 CC denotes or
T21371 31009-31017 NN denotes GST-RPS3
T21372 31018-31021 VB denotes was
T21373 31022-31031 VB denotes incubated
T21374 31032-31036 IN denotes with
T21375 31037-31048 JJ denotes recombinant
T21376 31049-31053 NN denotes IKKβ
T21377 31054-31061 NN denotes protein
T21378 31062-31064 IN denotes as
T21379 31065-31074 VB denotes described
T21380 31075-31080 IN denotes above
T21381 31081-31083 IN denotes in
T21382 31084-31086 DT denotes an
T21383 31087-31089 FW denotes in
T21384 31090-31095 FW denotes vitro
T21385 31096-31102 NN denotes kinase
T21386 31103-31108 NN denotes assay
T21387 31109-31117 NN denotes reaction
T21388 31118-31127 VB denotes conducted
T21389 31128-31135 IN denotes without
T21390 31136-31145 NN denotes 32P-γ-ATP
T21391 31146-31154 NN denotes labeling
T21392 31156-31159 DT denotes The
T21393 31160-31168 NN denotes reaction
T21394 31169-31172 VB denotes was
T21395 31173-31182 VB denotes separated
T21396 31183-31185 IN denotes by
T21397 31186-31194 NN denotes SDS-PAGE
T21398 31194-31195 -COMMA- denotes ,
T21399 31196-31199 CC denotes and
T21400 31200-31203 DT denotes the
T21401 31204-31211 NN denotes protein
T21402 31212-31215 NN denotes gel
T21403 31216-31219 VB denotes was
T21404 31220-31227 VB denotes stained
T21405 31228-31232 IN denotes with
T21406 31233-31242 NNP denotes Colloidal
T21407 31243-31247 NNP denotes Blue
T21408 31248-31249 -LRB- denotes (
T21409 31249-31259 NN denotes Invitrogen
T21410 31259-31260 -RRB- denotes )
T21411 31262-31265 DT denotes The
T21412 31266-31279 VB denotes corresponding
T21413 31280-31287 NN denotes protein
T21414 31288-31297 NN denotes fragments
T21415 31298-31302 VB denotes were
T21416 31303-31310 VB denotes excised
T21417 31311-31314 CC denotes and
T21418 31315-31324 VB denotes subjected
T21419 31325-31327 TO denotes to
T21420 31328-31335 NN denotes trypsin
T21421 31336-31345 NN denotes digestion
T21422 31346-31349 CC denotes and
T21423 31350-31358 NN denotes LC-MS/MS
T21424 31359-31361 IN denotes at
T21425 31362-31365 DT denotes the
T21426 31366-31370 NNP denotes Yale
T21427 31371-31377 NNP denotes Cancer
T21428 31378-31384 NNP denotes Center
T21429 31385-31389 NNP denotes Mass
T21430 31390-31402 NNP denotes Spectrometry
T21431 31403-31411 NNP denotes Resource
T21432 31412-31413 -LRB- denotes (
T21433 31413-31416 NNP denotes New
T21434 31417-31422 NNP denotes Haven
T21435 31422-31423 -COMMA- denotes ,
T21436 31424-31426 NN denotes CT
T21437 31426-31427 -RRB- denotes )
T21551 31430-31434 NN denotes RNAi
T21552 31435-31438 CC denotes and
T21553 31439-31451 NN denotes Transfection
T21554 31452-31455 DT denotes The
T21555 31456-31461 NN denotes siRNA
T21556 31462-31463 -LRB- denotes (
T21557 31463-31475 JJ denotes sense-strand
T21558 31476-31484 NN denotes sequence
T21559 31484-31485 -RRB- denotes )
T21560 31486-31490 NN denotes IKKα
T21561 31490-31491 -COMMA- denotes ,
T21562 31492-31520 NN denotes 5′-AUGACAGAGAAUGAUCAUGUUCUGC
T21563 31521-31524 NN denotes -3′
T21564 31524-31525 -COLON- denotes ;
T21565 31526-31530 NN denotes IKKβ
T21566 31530-31531 -COMMA- denotes ,
T21567 31532-31560 NN denotes 5′-GCAGCAAGGAGAACAGAGGUUAAUA
T21568 31561-31564 CD denotes -3′
T21569 31564-31565 -COLON- denotes ;
T21570 31566-31570 NN denotes IκBα
T21571 31570-31571 -COMMA- denotes ,
T21572 31572-31600 NN denotes 5′-GAGCUCCGAGACUUUCGAGGAAAUA
T21573 31601-31604 NN denotes -3′
T21574 31604-31605 -COLON- denotes ;
T21575 31606-31613 NN denotes RPS3-3′
T21576 31614-31617 NN denotes UTR
T21577 31617-31618 -COMMA- denotes ,
T21578 31619-31643 NN denotes 5′-GGAUGUUGCUCUCUAAAGACC
T21579 31644-31647 NN denotes -3′
T21580 31648-31649 -LRB- denotes (
T21581 31649-31659 NN denotes Invitrogen
T21582 31659-31660 -RRB- denotes )
T21583 31662-31671 JJ denotes Transient
T21584 31672-31684 NN denotes transfection
T21585 31685-31687 IN denotes of
T21586 31688-31693 NN denotes siRNA
T21587 31694-31697 CC denotes and
T21588 31698-31701 NN denotes DNA
T21589 31702-31712 NN denotes constructs
T21590 31713-31717 IN denotes into
T21591 31718-31724 NN denotes Jurkat
T21592 31725-31730 NN denotes cells
T21593 31731-31734 CC denotes and
T21594 31735-31739 NN denotes 293T
T21595 31740-31745 NN denotes cells
T21596 31746-31749 VB denotes was
T21597 31750-31759 VB denotes described
T21598 31760-31771 NN denotes previously6
T21712 31774-31785 JJ denotes Subcellular
T21713 31786-31799 NN denotes Fractionation
T21714 31800-31811 JJ denotes Subcellular
T21715 31812-31825 NN denotes fractionation
T21716 31826-31829 VB denotes was
T21717 31830-31839 VB denotes performed
T21718 31840-31842 IN denotes by
T21719 31843-31855 JJ denotes differential
T21720 31856-31870 NN denotes centrifugation
T21721 31871-31873 IN denotes as
T21722 31874-31884 RB denotes previously
T21723 31885-31895 NN denotes described6
T21724 31897-31904 RB denotes Briefly
T21725 31904-31905 -COMMA- denotes ,
T21726 31906-31911 NN denotes cells
T21727 31912-31916 VB denotes were
T21728 31917-31928 VB denotes resuspended
T21729 31929-31931 IN denotes in
T21730 31932-31940 JJ denotes ice-cold
T21731 31941-31947 NN denotes Buffer
T21732 31948-31949 NN denotes A
T21733 31950-31951 -LRB- denotes (
T21734 31951-31953 CD denotes 10
T21735 31954-31956 NN denotes mM
T21736 31957-31962 NN denotes HEPES
T21737 31963-31965 NN denotes pH
T21738 31966-31969 CD denotes 7.9
T21739 31969-31970 -COMMA- denotes ,
T21740 31971-31973 CD denotes 10
T21741 31974-31976 NN denotes mM
T21742 31977-31980 NN denotes KCl
T21743 31980-31981 -COMMA- denotes ,
T21744 31982-31985 CD denotes 1.5
T21745 31986-31988 NN denotes mM
T21746 31989-31994 NN denotes MgCl2
T21747 31994-31995 -COMMA- denotes ,
T21748 31996-31999 CD denotes 0.1
T21749 32000-32002 NN denotes mM
T21750 32003-32007 NN denotes EDTA
T21751 32007-32008 -COMMA- denotes ,
T21752 32009-32012 CD denotes 0.5
T21753 32013-32015 NN denotes mM
T21754 32016-32019 NN denotes DTT
T21755 32019-32020 -COMMA- denotes ,
T21756 32021-32024 CD denotes 0.4
T21757 32025-32026 NN denotes %
T21758 32027-32032 NN denotes NP-40
T21759 32032-32033 -COMMA- denotes ,
T21760 32034-32037 CD denotes 0.5
T21761 32038-32040 NN denotes mM
T21762 32041-32045 NN denotes PMSF
T21763 32045-32046 -COMMA- denotes ,
T21764 32047-32055 JJ denotes complete
T21765 32056-32064 NN denotes protease
T21766 32065-32074 NN denotes inhibitor
T21767 32075-32083 NN denotes cocktail
T21768 32083-32084 -RRB- denotes )
T21769 32085-32087 IN denotes at
T21770 32088-32089 CD denotes 4
T21771 32090-32092 NN denotes °C
T21772 32093-32096 IN denotes for
T21773 32097-32098 CD denotes 5
T21774 32099-32102 NN denotes min
T21775 32104-32111 NN denotes Lysates
T21776 32112-32116 VB denotes were
T21777 32117-32128 VB denotes centrifuged
T21778 32129-32131 IN denotes at
T21779 32132-32133 CD denotes 4
T21780 32134-32136 NN denotes °C
T21781 32136-32137 -COMMA- denotes ,
T21782 32138-32141 CD denotes 500
T21783 32142-32143 SYM denotes ×
T21784 32144-32145 NN denotes g
T21785 32146-32149 IN denotes for
T21786 32150-32151 CD denotes 3
T21787 32152-32155 NN denotes min
T21788 32155-32156 -COMMA- denotes ,
T21789 32157-32160 CC denotes and
T21790 32161-32173 NN denotes supernatants
T21791 32174-32178 VB denotes were
T21792 32179-32188 VB denotes collected
T21793 32189-32191 IN denotes as
T21794 32192-32201 JJ denotes cytosolic
T21795 32202-32211 NN denotes fractions
T21796 32213-32220 NN denotes Pellets
T21797 32221-32225 VB denotes were
T21798 32226-32235 VB denotes incubated
T21799 32236-32238 IN denotes in
T21800 32239-32245 NNP denotes Buffer
T21801 32246-32247 NNP denotes C
T21802 32248-32249 -LRB- denotes (
T21803 32249-32251 CD denotes 20
T21804 32252-32254 NN denotes mM
T21805 32255-32260 NN denotes HEPES
T21806 32261-32266 NN denotes pH7.9
T21807 32266-32267 -COMMA- denotes ,
T21808 32268-32271 CD denotes 420
T21809 32272-32274 NN denotes mM
T21810 32275-32279 NN denotes NaCl
T21811 32279-32280 -COMMA- denotes ,
T21812 32281-32284 CD denotes 1.5
T21813 32285-32287 NN denotes mM
T21814 32288-32293 NN denotes MgCl2
T21815 32293-32294 -COMMA- denotes ,
T21816 32295-32297 CD denotes 25
T21817 32297-32298 NN denotes %
T21818 32299-32307 NN denotes glycerol
T21819 32307-32308 -COMMA- denotes ,
T21820 32309-32312 CD denotes 0.5
T21821 32313-32315 NN denotes mM
T21822 32316-32320 NN denotes PMSF
T21823 32320-32321 -COMMA- denotes ,
T21824 32322-32325 CD denotes 0.2
T21825 32326-32328 NN denotes mM
T21826 32329-32333 NN denotes EDTA
T21827 32333-32334 -COMMA- denotes ,
T21828 32335-32338 CD denotes 0.5
T21829 32339-32341 NN denotes mM
T21830 32342-32345 NN denotes DTT
T21831 32345-32346 -COMMA- denotes ,
T21832 32347-32355 JJ denotes complete
T21833 32356-32364 NN denotes protease
T21834 32365-32374 NN denotes inhibitor
T21835 32375-32383 NN denotes cocktail
T21836 32383-32384 -RRB- denotes )
T21837 32385-32387 IN denotes at
T21838 32388-32389 CD denotes 4
T21839 32390-32392 NN denotes °C
T21840 32393-32396 IN denotes for
T21841 32397-32399 CD denotes 10
T21842 32400-32403 NN denotes min
T21843 32405-32417 NN denotes Supernatants
T21844 32418-32422 VB denotes were
T21845 32423-32432 VB denotes collected
T21846 32433-32435 IN denotes as
T21847 32436-32443 JJ denotes nuclear
T21848 32444-32453 NN denotes fractions
T21849 32454-32463 VB denotes following
T21850 32464-32465 DT denotes a
T21851 32466-32476 NN denotes centrifuge
T21852 32477-32479 IN denotes at
T21853 32480-32481 CD denotes 4
T21854 32482-32484 NN denotes °C
T21855 32484-32485 -COMMA- denotes ,
T21856 32486-32492 CD denotes 13,800
T21857 32493-32494 SYM denotes ×
T21858 32495-32496 NN denotes g
T21859 32497-32500 IN denotes for
T21860 32501-32503 CD denotes 10
T21861 32504-32507 NN denotes min
T22041 32510-32520 NNP denotes Luciferase
T22042 32521-32529 NNP denotes Reporter
T22043 32530-32534 NNP denotes Gene
T22044 32535-32541 NN denotes Assays
T22045 32542-32552 NN denotes Luciferase
T22046 32553-32561 NN denotes reporter
T22047 32562-32566 NN denotes gene
T22048 32567-32573 NN denotes assays
T22049 32574-32578 VB denotes were
T22050 32579-32588 VB denotes performed
T22051 32589-32591 IN denotes as
T22052 32592-32602 RB denotes previously
T22053 32603-32613 NN denotes described6
T22054 32615-32622 RB denotes Briefly
T22055 32622-32623 -COMMA- denotes ,
T22056 32624-32629 NN denotes cells
T22057 32630-32634 VB denotes were
T22058 32635-32648 VB denotes cotransfected
T22059 32649-32651 IN denotes at
T22060 32652-32653 DT denotes a
T22061 32654-32659 NN denotes ratio
T22062 32660-32662 IN denotes of
T22063 32663-32665 CD denotes 10
T22064 32665-32666 -COLON- denotes :
T22065 32666-32667 CD denotes 1
T22066 32668-32672 IN denotes with
T22067 32673-32680 JJ denotes various
T22068 32681-32696 JJ denotes promoter-driven
T22069 32697-32704 NN denotes firefly
T22070 32705-32715 NN denotes luciferase
T22071 32716-32726 NN denotes constructs
T22072 32727-32729 TO denotes to
T22073 32730-32733 DT denotes the
T22074 32734-32741 NNP denotes Renilla
T22075 32742-32752 NN denotes luciferase
T22076 32753-32758 NN denotes pTKRL
T22077 32759-32766 NN denotes plasmid
T22078 32766-32767 -COMMA- denotes ,
T22079 32768-32776 RB denotes together
T22080 32777-32781 IN denotes with
T22081 32782-32791 VB denotes indicated
T22082 32792-32800 NN denotes plasmids
T22083 32802-32807 NN denotes Cells
T22084 32808-32812 VB denotes were
T22085 32813-32821 VB denotes cultured
T22086 32822-32825 IN denotes for
T22087 32826-32829 CD denotes 1–2
T22088 32830-32834 NN denotes days
T22089 32835-32838 CC denotes and
T22090 32839-32843 RB denotes then
T22091 32844-32854 VB denotes stimulated
T22092 32855-32857 IN denotes in
T22093 32858-32868 NN denotes triplicate
T22094 32869-32875 IN denotes before
T22095 32876-32883 NN denotes harvest
T22096 32885-32892 NN denotes Lysates
T22097 32893-32897 VB denotes were
T22098 32898-32906 VB denotes analyzed
T22099 32907-32912 VB denotes using
T22100 32913-32916 DT denotes the
T22101 32917-32932 NN denotes Dual-Luciferase
T22102 32933-32936 NN denotes Kit
T22103 32937-32938 -LRB- denotes (
T22104 32938-32945 NN denotes Promega
T22105 32945-32946 -RRB- denotes )
T22217 32949-32958 NN denotes Chromatin
T22218 32959-32978 NN denotes Immunoprecipitation
T22219 32979-32980 -LRB- denotes (
T22220 32980-32984 NN denotes ChIP
T22221 32984-32985 -RRB- denotes )
T22222 32986-32990 NN denotes ChIP
T22223 32991-32997 NN denotes assays
T22224 32998-33001 VB denotes was
T22225 33002-33011 VB denotes performed
T22226 33012-33014 IN denotes as
T22227 33015-33025 RB denotes previously
T22228 33026-33036 NN denotes described6
T22229 33038-33041 DT denotes The
T22230 33042-33049 NN denotes primers
T22231 33050-33054 VB denotes used
T22232 33055-33057 TO denotes to
T22233 33058-33065 VB denotes amplify
T22234 33066-33069 DT denotes the
T22235 33070-33078 NN denotes promoter
T22236 33079-33085 NN denotes region
T22237 33086-33094 JJ denotes adjacent
T22238 33095-33097 TO denotes to
T22239 33098-33101 DT denotes the
T22240 33102-33104 NN denotes κB
T22241 33105-33110 NN denotes sites
T22242 33111-33113 IN denotes of
T22243 33114-33117 NN denotes IL8
T22244 33118-33121 CC denotes and
T22245 33122-33128 NN denotes NFKBIA
T22246 33128-33129 -COMMA- denotes ,
T22247 33130-33132 RB denotes as
T22248 33133-33137 RB denotes well
T22249 33138-33140 IN denotes as
T22250 33141-33145 NN denotes ACTB
T22251 33146-33150 VB denotes have
T22252 33151-33155 VB denotes been
T22253 33156-33166 NN denotes described6
T22328 33169-33187 NN denotes Immunofluorescence
T22329 33188-33198 NNP denotes Microscopy
T22330 33199-33207 JJ denotes Confocal
T22331 33208-33218 NN denotes microscopy
T22332 33219-33222 VB denotes was
T22333 33223-33232 VB denotes performed
T22334 33233-33235 IN denotes as
T22335 33236-33246 RB denotes previously
T22336 33247-33257 NN denotes described6
T22337 33259-33266 RB denotes Briefly
T22338 33266-33267 -COMMA- denotes ,
T22339 33268-33273 NN denotes cells
T22340 33274-33278 VB denotes were
T22341 33279-33284 VB denotes fixed
T22342 33285-33289 IN denotes with
T22343 33290-33291 CD denotes 4
T22344 33292-33293 NN denotes %
T22345 33294-33310 NN denotes paraformaldehyde
T22346 33311-33313 IN denotes in
T22347 33314-33317 NNP denotes PBS
T22348 33318-33321 CC denotes and
T22349 33322-33326 RB denotes then
T22350 33327-33335 NNP denotes Cellspin
T22351 33336-33343 VB denotes mounted
T22352 33344-33348 IN denotes onto
T22353 33349-33355 NN denotes slides
T22354 33357-33360 DT denotes The
T22355 33361-33366 VB denotes fixed
T22356 33367-33372 NN denotes cells
T22357 33373-33377 VB denotes were
T22358 33378-33382 RB denotes then
T22359 33383-33396 VB denotes permeabilized
T22360 33397-33401 IN denotes with
T22361 33402-33406 CD denotes 0.05
T22362 33407-33408 NN denotes %
T22363 33409-33415 NN denotes Triton
T22364 33416-33421 NN denotes X-100
T22365 33422-33424 IN denotes in
T22366 33425-33428 NNP denotes PBS
T22367 33429-33432 CC denotes and
T22368 33433-33440 VB denotes stained
T22369 33441-33445 IN denotes with
T22370 33446-33461 JJ denotes FITC-conjugated
T22371 33462-33468 NN denotes rabbit
T22372 33469-33478 JJ denotes anti-RPS3
T22373 33479-33489 NN denotes antibodies
T22374 33490-33491 -LRB- denotes (
T22375 33491-33496 NNP denotes Primm
T22376 33497-33504 NNP denotes Biotech
T22377 33504-33505 -RRB- denotes )
T22378 33505-33506 -COMMA- denotes ,
T22379 33507-33509 CC denotes or
T22380 33510-33520 NNP denotes AlexaFluor
T22381 33521-33535 JJ denotes 594-conjugated
T22382 33536-33539 NN denotes rat
T22383 33540-33549 JJ denotes anti-Flag
T22384 33550-33560 NN denotes antibodies
T22385 33561-33562 -LRB- denotes (
T22386 33562-33564 NN denotes BD
T22387 33564-33565 -RRB- denotes )
T22388 33566-33569 IN denotes for
T22389 33570-33572 CD denotes 40
T22390 33573-33576 NN denotes min
T22391 33577-33585 RB denotes together
T22392 33586-33590 IN denotes with
T22393 33591-33592 CD denotes 1
T22394 33593-33598 NN denotes μg/ml
T22395 33599-33601 IN denotes of
T22396 33602-33609 NNP denotes Hoechst
T22397 33610-33615 CD denotes 33342
T22398 33616-33617 -LRB- denotes (
T22399 33617-33622 NN denotes Sigma
T22400 33622-33623 -RRB- denotes )
T22401 33624-33627 IN denotes for
T22402 33628-33629 CD denotes 5
T22403 33630-33633 NN denotes min
T22404 33634-33636 IN denotes at
T22405 33637-33639 CD denotes 25
T22406 33640-33643 NNP denotes °C.
T22407 33644-33647 DT denotes The
T22408 33648-33654 NN denotes slides
T22409 33655-33659 VB denotes were
T22410 33660-33664 RB denotes then
T22411 33665-33671 VB denotes rinsed
T22412 33672-33676 IN denotes with
T22413 33677-33680 NNP denotes PBS
T22414 33681-33686 CD denotes three
T22415 33687-33692 NN denotes times
T22416 33693-33696 CC denotes and
T22417 33697-33702 NN denotes cover
T22418 33703-33710 VB denotes mounted
T22419 33711-33714 IN denotes for
T22420 33715-33727 NN denotes fluorescence
T22421 33728-33738 NN denotes microscopy
T22550 33741-33760 NN denotes Immunoprecipitation
T22551 33761-33764 CC denotes and
T22552 33765-33775 NN denotes immunoblot
T22553 33776-33779 DT denotes The
T22554 33780-33785 NN denotes cells
T22555 33786-33790 VB denotes were
T22556 33791-33800 VB denotes harvested
T22557 33801-33804 CC denotes and
T22558 33805-33810 VB denotes lysed
T22559 33811-33813 IN denotes on
T22560 33814-33817 NN denotes ice
T22561 33818-33820 IN denotes by
T22562 33821-33824 CD denotes 0.4
T22563 33825-33827 NN denotes ml
T22564 33828-33830 IN denotes of
T22565 33831-33834 DT denotes the
T22566 33835-33843 VB denotes modified
T22567 33844-33848 NN denotes RIPA
T22568 33849-33855 NN denotes buffer
T22569 33856-33857 -LRB- denotes (
T22570 33857-33859 CD denotes 50
T22571 33860-33862 NN denotes mM
T22572 33863-33871 NN denotes Tris-HCl
T22573 33872-33873 -LRB- denotes [
T22574 33873-33875 NN denotes pH
T22575 33876-33879 CD denotes 7.4
T22576 33879-33880 -RRB- denotes ]
T22577 33880-33881 -COMMA- denotes ,
T22578 33882-33883 CD denotes 1
T22579 33883-33884 NN denotes %
T22580 33885-33890 NN denotes NP-40
T22581 33890-33891 -COMMA- denotes ,
T22582 33892-33896 CD denotes 0.25
T22583 33896-33897 NN denotes %
T22584 33898-33913 JJ denotes Na-deoxycholate
T22585 33913-33914 -COMMA- denotes ,
T22586 33915-33918 CD denotes 150
T22587 33919-33921 NN denotes mM
T22588 33922-33926 NN denotes NaCl
T22589 33926-33927 -COMMA- denotes ,
T22590 33928-33929 CD denotes 1
T22591 33930-33932 NN denotes mM
T22592 33933-33937 NN denotes EDTA
T22593 33937-33938 -COMMA- denotes ,
T22594 33939-33940 CD denotes 1
T22595 33941-33943 NN denotes mM
T22596 33944-33948 NN denotes PMSF
T22597 33948-33949 -COMMA- denotes ,
T22598 33950-33951 CD denotes 1
T22599 33952-33954 NN denotes mM
T22600 33955-33961 NN denotes Na3VO4
T22601 33961-33962 -COMMA- denotes ,
T22602 33963-33964 CD denotes 1
T22603 33965-33967 NN denotes mM
T22604 33968-33971 NN denotes NaF
T22605 33971-33972 -RRB- denotes )
T22606 33973-33985 VB denotes supplemented
T22607 33986-33990 IN denotes with
T22608 33991-33992 CD denotes 1
T22609 33993-33994 SYM denotes ×
T22610 33995-34003 NN denotes protease
T22611 34004-34013 NN denotes inhibitor
T22612 34014-34022 NN denotes cocktail
T22613 34023-34024 -LRB- denotes (
T22614 34024-34029 NN denotes Roche
T22615 34029-34030 -RRB- denotes )
T22616 34031-34034 CC denotes and
T22617 34035-34036 CD denotes 1
T22618 34037-34038 CC denotes ×
T22619 34039-34050 NN denotes phosphatase
T22620 34051-34060 NN denotes inhibitor
T22621 34061-34069 NN denotes cocktail
T22622 34070-34073 NN denotes set
T22623 34074-34075 CD denotes I
T22624 34076-34077 -LRB- denotes (
T22625 34077-34080 NNP denotes EMD
T22626 34081-34092 NNP denotes Biosciences
T22627 34092-34093 -RRB- denotes )
T22628 34094-34097 IN denotes for
T22629 34098-34100 CD denotes 30
T22630 34101-34104 NN denotes min
T22631 34106-34109 DT denotes The
T22632 34110-34117 NN denotes lysates
T22633 34118-34122 VB denotes were
T22634 34123-34134 VB denotes centrifuged
T22635 34135-34137 IN denotes at
T22636 34138-34144 CD denotes 10,000
T22637 34145-34146 SYM denotes ×
T22638 34147-34148 NN denotes g
T22639 34149-34151 IN denotes at
T22640 34152-34153 CD denotes 4
T22641 34154-34156 NN denotes °C
T22642 34157-34160 IN denotes for
T22643 34161-34163 CD denotes 10
T22644 34164-34167 NN denotes min
T22645 34168-34170 TO denotes to
T22646 34171-34177 VB denotes remove
T22647 34178-34187 JJ denotes insoluble
T22648 34188-34196 NN denotes material
T22649 34198-34203 IN denotes After
T22650 34204-34215 VB denotes normalizing
T22651 34216-34223 NN denotes protein
T22652 34224-34238 NN denotes concentrations
T22653 34238-34239 -COMMA- denotes ,
T22654 34240-34247 NN denotes lysates
T22655 34248-34252 VB denotes were
T22656 34253-34262 VB denotes subjected
T22657 34263-34265 TO denotes to
T22658 34266-34285 NN denotes immunoprecipitation
T22659 34286-34288 IN denotes by
T22660 34289-34295 VB denotes adding
T22661 34296-34298 CD denotes 10
T22662 34299-34304 NN denotes mg/ml
T22663 34305-34316 JJ denotes appropriate
T22664 34317-34325 NN denotes antibody
T22665 34326-34330 CC denotes plus
T22666 34331-34333 CD denotes 30
T22667 34334-34336 NN denotes ml
T22668 34337-34339 IN denotes of
T22669 34340-34347 NN denotes protein
T22670 34348-34357 NN denotes G-agarose
T22671 34358-34359 -LRB- denotes (
T22672 34359-34364 NNP denotes Roche
T22673 34364-34365 -RRB- denotes )
T22674 34365-34366 -COMMA- denotes ,
T22675 34367-34370 CC denotes and
T22676 34371-34378 VB denotes rotated
T22677 34379-34382 IN denotes for
T22678 34383-34385 IN denotes at
T22679 34386-34391 JJ denotes least
T22680 34392-34393 CD denotes 2
T22681 34394-34395 NN denotes h
T22682 34396-34398 IN denotes at
T22683 34399-34403 NNP denotes 4°C.
T22684 34404-34407 DT denotes The
T22685 34408-34420 NN denotes precipitates
T22686 34421-34425 VB denotes were
T22687 34426-34432 VB denotes washed
T22688 34433-34435 IN denotes at
T22689 34436-34441 JJ denotes least
T22690 34442-34446 CD denotes five
T22691 34447-34452 NN denotes times
T22692 34453-34457 IN denotes with
T22693 34458-34462 JJ denotes cold
T22694 34463-34468 NN denotes lysis
T22695 34469-34475 NN denotes buffer
T22696 34476-34484 VB denotes followed
T22697 34485-34487 IN denotes by
T22698 34488-34498 NN denotes separation
T22699 34499-34501 IN denotes by
T22700 34502-34510 NN denotes SDS-PAGE
T22701 34511-34516 IN denotes under
T22702 34517-34524 VB denotes reduced
T22703 34525-34528 CC denotes and
T22704 34529-34539 VB denotes denaturing
T22705 34540-34550 NN denotes conditions
T22706 34552-34566 NN denotes Nitrocellulose
T22707 34567-34576 NN denotes membranes
T22708 34577-34581 VB denotes were
T22709 34582-34589 VB denotes blocked
T22710 34590-34592 IN denotes in
T22711 34593-34594 CD denotes 5
T22712 34595-34596 NN denotes %
T22713 34597-34603 JJ denotes nonfat
T22714 34604-34608 NN denotes milk
T22715 34609-34611 IN denotes in
T22716 34612-34615 CD denotes 0.1
T22717 34616-34617 NN denotes %
T22718 34618-34627 JJ denotes PBS-Tween
T22719 34628-34630 CD denotes 20
T22720 34631-34632 -LRB- denotes (
T22721 34632-34637 NN denotes PBS-T
T22722 34637-34638 -RRB- denotes )
T22723 34638-34639 -COMMA- denotes ,
T22724 34640-34646 VB denotes probed
T22725 34647-34651 IN denotes with
T22726 34652-34660 JJ denotes specific
T22727 34661-34671 NN denotes antibodies
T22728 34672-34674 IN denotes as
T22729 34675-34684 VB denotes described
T22730 34685-34696 NN denotes previously6
T22731 34698-34701 IN denotes For
T22732 34702-34716 NN denotes immunoblotting
T22733 34717-34719 IN denotes of
T22734 34720-34734 VB denotes phosphorylated
T22735 34735-34743 NN denotes proteins
T22736 34743-34744 -COMMA- denotes ,
T22737 34745-34749 NN denotes gels
T22738 34750-34754 VB denotes were
T22739 34755-34766 VB denotes transferred
T22740 34767-34769 TO denotes to
T22741 34770-34786 JJ denotes methanol-treated
T22742 34787-34801 NN denotes polyvinylidene
T22743 34802-34810 NN denotes chloride
T22744 34811-34820 NN denotes membranes
T22745 34820-34821 -COMMA- denotes ,
T22746 34822-34831 VB denotes retreated
T22747 34832-34836 IN denotes with
T22748 34837-34845 NN denotes methanol
T22749 34845-34846 -COMMA- denotes ,
T22750 34847-34850 CC denotes and
T22751 34851-34856 VB denotes dried
T22752 34857-34860 IN denotes for
T22753 34861-34863 CD denotes 30
T22754 34864-34867 NN denotes min
T22755 34869-34874 NN denotes Blots
T22756 34875-34879 VB denotes were
T22757 34880-34887 VB denotes blocked
T22758 34888-34890 IN denotes in
T22759 34891-34892 CD denotes 5
T22760 34893-34894 NN denotes %
T22761 34895-34901 JJ denotes bovine
T22762 34902-34907 NN denotes serum
T22763 34908-34915 NN denotes albumin
T22764 34916-34918 IN denotes in
T22765 34919-34922 CD denotes 0.1
T22766 34923-34924 NN denotes %
T22767 34925-34929 NNP denotes Tris
T22768 34930-34938 VB denotes buffered
T22769 34939-34951 JJ denotes saline-Tween
T22770 34952-34954 CD denotes 20
T22771 34955-34956 -LRB- denotes (
T22772 34956-34961 NN denotes TBS-T
T22773 34961-34962 -RRB- denotes )
T22774 34962-34963 -COMMA- denotes ,
T22775 34964-34967 CC denotes and
T22776 34968-34974 VB denotes probed
T22777 34975-34979 IN denotes with
T22778 34980-34988 JJ denotes specific
T22779 34989-34999 NN denotes antibodies
T22780 35000-35002 IN denotes as
T22781 35003-35012 VB denotes described
T22782 35013-35025 NN denotes previously46
T22783 35027-35032 NN denotes Bands
T22784 35033-35037 VB denotes were
T22785 35038-35044 VB denotes imaged
T22786 35045-35047 IN denotes by
T22787 35048-35051 DT denotes the
T22788 35052-35057 NNP denotes Super
T22789 35058-35067 NN denotes Signaling
T22790 35068-35074 NN denotes system
T22791 35075-35076 -LRB- denotes (
T22792 35076-35082 NN denotes Pierce
T22793 35082-35083 -RRB- denotes )
T22794 35084-35093 VB denotes according
T22795 35094-35096 TO denotes to
T22796 35097-35100 DT denotes the
T22797 35101-35113 NN denotes manufacturer
T22798 35113-35115 POS denotes 's
T22799 35116-35128 NN denotes instructions
T23105 35131-35136 NN denotes ELISA
T23106 35137-35140 DT denotes The
T23107 35141-35147 NN denotes amount
T23108 35148-35150 IN denotes of
T23109 35151-35155 NN denotes IL-8
T23110 35156-35163 JJ denotes present
T23111 35164-35166 IN denotes in
T23112 35167-35179 NN denotes supernatants
T23113 35180-35189 VB denotes collected
T23114 35190-35194 IN denotes from
T23115 35195-35201 NN denotes Jurkat
T23116 35202-35206 NN denotes cell
T23117 35207-35214 NN denotes culture
T23118 35215-35218 VB denotes was
T23119 35219-35227 VB denotes measured
T23120 35228-35233 VB denotes using
T23121 35234-35235 DT denotes a
T23122 35236-35241 JJ denotes Human
T23123 35242-35255 NN denotes Interleukin-8
T23124 35256-35261 NN denotes ELISA
T23125 35262-35274 NN denotes Ready-SET-Go
T23126 35275-35278 NN denotes kit
T23127 35279-35280 -LRB- denotes (
T23128 35280-35291 NN denotes eBioscience
T23129 35291-35292 -RRB- denotes )
T23130 35293-35302 VB denotes according
T23131 35303-35305 TO denotes to
T23132 35306-35309 DT denotes the
T23133 35310-35322 NN denotes manufacturer
T23134 35322-35324 POS denotes 's
T23135 35325-35337 NN denotes instructions
T23195 35340-35344 NN denotes Cell
T23196 35345-35355 NN denotes Infections
T23197 35356-35360 NN denotes HeLa
T23198 35361-35366 NN denotes cells
T23199 35367-35371 VB denotes were
T23200 35372-35380 VB denotes infected
T23201 35381-35385 IN denotes with
T23202 35386-35388 FW denotes E.
T23203 35389-35393 FW denotes coli
T23204 35394-35398 NN denotes O157
T23205 35398-35399 -COLON- denotes :
T23206 35399-35401 NN denotes H7
T23207 35402-35404 CC denotes or
T23208 35405-35407 FW denotes C.
T23209 35408-35417 NN denotes rodentium
T23210 35418-35425 NN denotes strains
T23211 35426-35428 IN denotes as
T23212 35429-35438 VB denotes described
T23213 35439-35450 NN denotes previously9
T23243 35453-35473 NN denotes Immunohistochemistry
T23244 35474-35485 JJ denotes Gnotobiotic
T23245 35486-35493 NN denotes piglets
T23246 35494-35498 VB denotes were
T23247 35499-35507 VB denotes infected
T23248 35508-35512 IN denotes with
T23249 35513-35515 FW denotes E.
T23250 35516-35520 FW denotes coli
T23251 35521-35525 NN denotes O157
T23252 35525-35526 -COLON- denotes :
T23253 35526-35528 NN denotes H7
T23254 35529-35536 NN denotes strains
T23255 35537-35539 IN denotes as
T23256 35540-35549 VB denotes described
T23257 35550-35561 NN denotes previously9
T23258 35563-35569 JJ denotes Spiral
T23259 35570-35575 NN denotes colon
T23260 35576-35585 NN denotes specimens
T23261 35586-35590 VB denotes were
T23262 35591-35600 VB denotes collected
T23263 35601-35603 IN denotes at
T23264 35604-35612 NN denotes necropsy
T23265 35613-35616 CC denotes and
T23266 35617-35625 VB denotes embedded
T23267 35626-35628 IN denotes in
T23268 35629-35637 NN denotes paraffin
T23269 35639-35647 NN denotes Paraffin
T23270 35648-35658 NN denotes sectioning
T23271 35659-35662 CC denotes and
T23272 35663-35682 JJ denotes immunohistochemical
T23273 35683-35691 NN denotes staining
T23274 35692-35697 VB denotes using
T23275 35698-35710 NN denotes phospho-RPS3
T23276 35711-35719 NN denotes antibody
T23277 35720-35724 VB denotes were
T23278 35725-35734 VB denotes performed
T23279 35735-35737 IN denotes by
T23280 35738-35747 NNP denotes Histoserv
T23281 35748-35751 NNP denotes Inc
T18147 24010-24013 VB denotes was
T18438 25944-25954 JJ denotes protective
R78 T100 T102 modOf IKKβ,regulates
R79 T100 T111 arg1Of IKKβ,:
R80 T101 T102 arg1Of phosphorylation,regulates
R81 T105 T103 arg1Of translocation,RPS3
R82 T105 T104 arg1Of translocation,nuclear
R83 T105 T106 arg1Of translocation,and
R84 T106 T102 arg2Of and,regulates
R85 T110 T106 arg2Of coli O157,and
R86 T110 T107 arg1Of coli O157,NF-κB
R87 T110 T108 arg1Of coli O157,function
R88 T110 T109 arg1Of coli O157,during Escherichia
R89 T113 T100 arg1Of infection,IKKβ
R90 T113 T112 arg1Of infection,H7
R91 T114 T115 arg1Of NF-κB,is
R92 T115 T123 arg1Of is,and
R93 T119 T115 arg2Of regulator,is
R94 T119 T116 arg1Of regulator,a
R95 T119 T117 arg1Of regulator,major
R96 T119 T118 arg1Of regulator,gene
R97 T119 T120 arg1Of regulator,in
R98 T122 T120 arg2Of responses,in
R99 T122 T121 arg1Of responses,immune
R100 T126 T124 arg1Of S3,ribosomal
R101 T126 T125 arg1Of S3,protein
R102 T126 T127 arg1Of S3,(
R103 T126 T130 arg1Of S3,is
R104 T128 T127 arg2Of RPS3,(
R105 T129 T127 arg3Of ),(
R106 T130 T123 arg2Of is,and
R107 T133 T130 arg2Of subunit,is
R108 T133 T131 arg1Of subunit,an
R109 T133 T132 arg1Of subunit,NF-κB
R110 T133 T134 arg1Of subunit,that
R111 T133 T135 arg1Of subunit,directs
R112 T138 T135 arg2Of transcription,directs
R113 T138 T136 arg1Of transcription,specific
R114 T138 T137 arg1Of transcription,gene
R115 T142 T139 arg1Of is,However
R116 T142 T140 arg1Of is,","
R117 T143 T142 arg2Of unknown,is
R118 T144 T141 arg1Of how,it
R119 T144 T142 arg1Of how,is
R120 T144 T143 arg1Of how,unknown
R121 T147 T145 arg1Of translocation,RPS3
R122 T147 T146 arg1Of translocation,nuclear
R123 T147 T148 arg1Of translocation,is
R124 T147 T149 arg2Of translocation,regulated
R125 T149 T144 arg1Of regulated,how
R126 T149 T148 arg2Of regulated,is
R127 T151 T152 arg1Of we,report
R128 T152 T150 arg1Of report,Here
R129 T155 T154 arg1Of phosphorylation,IKKβ
R130 T155 T156 arg1Of phosphorylation,of
R131 T155 T162 arg1Of phosphorylation,was
R132 T155 T163 arg1Of phosphorylation,crucial
R133 T157 T156 arg2Of serine,of
R134 T157 T158 arg1Of serine,209
R135 T157 T159 arg1Of serine,(
R136 T160 T159 arg2Of S209,(
R137 T161 T159 arg3Of ),(
R138 T162 T152 arg2Of was,report
R139 T162 T153 arg1Of was,that
R140 T162 T168 arg1Of was,in
R141 T163 T162 arg2Of crucial,was
R142 T163 T164 arg1Of crucial,for
R143 T167 T164 arg2Of localization,for
R144 T167 T165 arg1Of localization,RPS3
R145 T167 T166 arg1Of localization,nuclear
R146 T168 T170 arg1Of in,to
R147 T169 T168 arg2Of response,in
R148 T172 T168 arg3Of stimuli,in
R149 T172 T171 arg1Of stimuli,activating
R150 T180 T176 arg1Of O157,foodborne
R151 T180 T177 arg1Of O157,pathogen
R152 T180 T178 arg1Of O157,Escherichia
R153 T180 T179 arg1Of O157,coli
R154 T180 T181 arg1Of O157,:
R155 T181 T175 arg1Of :,the
R156 T181 T187 arg1Of :,inhibited
R157 T181 T192 arg1Of :,blocked
R158 T181 T197 arg1Of :,promoting
R159 T181 T203 arg1Of :,decreasing
R160 T185 T181 arg2Of NleH1,:
R161 T185 T182 arg1Of NleH1,H7
R162 T185 T183 arg1Of NleH1,virulence
R163 T185 T184 arg1Of NleH1,protein
R164 T187 T191 arg1Of inhibited,and
R165 T190 T187 arg2Of phosphorylation,inhibited
R166 T190 T188 arg1Of phosphorylation,RPS3
R167 T190 T189 arg1Of phosphorylation,S209
R168 T191 T173 arg1Of and,Moreover
R169 T191 T174 arg1Of and,","
R170 T191 T186 arg1Of and,specifically
R171 T191 T195 arg1Of and,","
R172 T191 T197 modOf and,promoting
R173 T191 T203 modOf and,decreasing
R174 T192 T191 arg2Of blocked,and
R175 T194 T192 arg2Of function,blocked
R176 T194 T193 arg1Of function,RPS3
R177 T197 T202 arg1Of promoting,but
R178 T199 T200 arg1Of colonization,and
R179 T200 T197 arg2Of and,promoting
R180 T200 T198 arg1Of and,bacterial
R181 T201 T200 arg2Of diarrhea,and
R182 T202 T196 arg1Of but,thereby
R183 T203 T202 arg2Of decreasing,but
R184 T203 T205 arg1Of decreasing,in
R185 T204 T203 arg2Of mortality,decreasing
R186 T210 T205 arg2Of model,in
R187 T210 T206 arg1Of model,a
R188 T210 T207 arg1Of model,gnotobiotic
R189 T210 T208 arg1Of model,piglet
R190 T210 T209 arg1Of model,infection
R191 T215 T213 arg1Of modification,the
R192 T215 T214 arg1Of modification,IKKβ-dependent
R193 T215 T216 arg1Of modification,of
R194 T215 T223 arg1Of modification,promotes
R195 T220 T216 arg2Of acid,of
R196 T220 T217 arg1Of acid,a
R197 T220 T218 arg1Of acid,specific
R198 T220 T219 arg1Of acid,amino
R199 T220 T221 arg1Of acid,in
R200 T222 T221 arg2Of RPS3,in
R201 T223 T211 arg1Of promotes,Thus
R202 T223 T212 arg1Of promotes,","
R203 T226 T223 arg2Of functions,promotes
R204 T226 T224 arg1Of functions,specific
R205 T226 T225 arg1Of functions,NF-κB
R206 T226 T227 arg1Of functions,that
R207 T226 T228 arg1Of functions,underlie
R208 T232 T228 arg2Of mechanisms,underlie
R209 T232 T229 arg1Of mechanisms,the
R210 T232 T230 arg1Of mechanisms,molecular
R211 T232 T231 arg1Of mechanisms,pathogenetic
R212 T232 T233 arg1Of mechanisms,of
R213 T232 T237 arg1Of mechanisms,:
R214 T236 T233 arg2Of O157,of
R215 T236 T234 arg1Of O157,E.
R216 T236 T235 arg1Of O157,coli
R217 T238 T237 arg2Of H7,:
R626 T795 T793 arg1Of B,Nuclear
R627 T795 T794 arg1Of B,Factor-kappa
R628 T795 T796 arg1Of B,(
R629 T795 T799 arg1Of B,regulates
R630 T797 T796 arg2Of NF-κB,(
R631 T798 T796 arg3Of ),(
R632 T799 T803 arg1Of regulates,and
R633 T802 T799 arg2Of functions,regulates
R634 T802 T800 arg1Of functions,crucial
R635 T802 T801 arg1Of functions,cellular
R636 T805 T804 arg1Of stimuli,diverse
R637 T805 T806 arg1Of stimuli,activate
R638 T806 T803 arg2Of activate,and
R639 T810 T806 arg2Of factor,activate
R640 T810 T807 arg1Of factor,this
R641 T810 T808 arg1Of factor,pleiotropic
R642 T810 T809 arg1Of factor,transcription
R643 T810 T811 arg1Of factor,","
R644 T810 T812 arg1Of factor,which
R645 T810 T815 arg1Of factor,regulates
R646 T814 T813 arg2Of turn,in
R647 T815 T813 arg1Of regulates,in
R648 T818 T815 arg2Of array,regulates
R649 T818 T816 arg1Of array,a
R650 T818 T817 arg1Of array,vast
R651 T818 T819 arg1Of array,of
R652 T821 T819 arg2Of targets1-3,of
R653 T821 T820 arg1Of targets1-3,genetic
R654 T826 T822 arg1Of subunits,The
R655 T826 T823 arg1Of subunits,best-known
R656 T826 T824 arg1Of subunits,mammalian
R657 T826 T825 arg1Of subunits,NF-κB
R658 T826 T827 arg1Of subunits,are
R659 T829 T827 arg2Of proteins,are
R660 T829 T828 arg1Of proteins,Rel
R661 T829 T830 arg1Of proteins,","
R662 T829 T831 arg1Of proteins,including
R663 T832 T833 arg1Of RelA,(
R664 T832 T836 arg1Of RelA,","
R665 T834 T833 arg2Of p65,(
R666 T835 T833 arg3Of ),(
R667 T836 T838 arg1Of ",",","
R668 T837 T836 arg2Of RelB,","
R669 T838 T840 arg1Of ",",","
R670 T839 T838 arg2Of c-Rel,","
R671 T840 T843 arg1Of ",",and
R672 T841 T840 arg2Of p50,","
R673 T843 T831 arg2Of and,including
R674 T843 T842 arg1Of and,","
R675 T844 T845 arg1Of p52,(
R676 T846 T843 arg2Of refs,and
R677 T846 T844 arg1Of refs,p52
R678 T847 T848 arg1Of "4, 5",)
R679 T851 T853 arg1Of we,demonstrated
R680 T853 T849 arg1Of demonstrated,However
R681 T853 T850 arg1Of demonstrated,","
R682 T853 T852 arg1Of demonstrated,recently
R683 T857 T855 arg1Of S3,ribosomal
R684 T857 T856 arg1Of S3,protein
R685 T857 T858 arg1Of S3,(
R686 T857 T861 arg1Of S3,is
R687 T859 T858 arg2Of RPS3,(
R688 T860 T858 arg3Of ),(
R689 T861 T853 arg2Of is,demonstrated
R690 T861 T854 arg1Of is,that
R691 T865 T861 arg2Of subunit,is
R692 T865 T862 arg1Of subunit,a
R693 T865 T863 arg1Of subunit,key
R694 T865 T864 arg1Of subunit,non-Rel
R695 T865 T866 arg1Of subunit,of
R696 T870 T866 arg2Of complexes6,of
R697 T870 T867 arg1Of complexes6,certain
R698 T870 T868 arg1Of complexes6,native
R699 T870 T869 arg1Of complexes6,NF-κB
R700 T871 T872 arg1Of RPS3,is
R701 T871 T873 arg2Of RPS3,defined
R702 T873 T872 arg2Of defined,is
R703 T873 T874 arg1Of defined,as
R704 T873 T880 arg1Of defined,","
R705 T873 T881 arg1Of defined,because
R706 T877 T874 arg2Of subunit,as
R707 T877 T875 arg1Of subunit,a
R708 T877 T876 arg1Of subunit,“specifier”
R709 T877 T878 arg1Of subunit,of
R710 T879 T878 arg2Of NF-κB,of
R711 T882 T883 arg1Of it,facilitates
R712 T883 T881 arg2Of facilitates,because
R713 T887 T883 arg2Of binding,facilitates
R714 T887 T884 arg1Of binding,high
R715 T887 T885 arg1Of binding,affinity
R716 T887 T886 arg1Of binding,DNA
R717 T887 T889 arg1Of binding,determining
R718 T889 T888 arg1Of determining,thus
R719 T892 T889 arg2Of specificity,determining
R720 T892 T890 arg1Of specificity,the
R721 T892 T891 arg1Of specificity,regulatory
R722 T892 T893 arg1Of specificity,of
R723 T892 T895 arg1Of specificity,for
R724 T894 T893 arg2Of NF-κB,of
R725 T898 T895 arg2Of genes7,for
R726 T898 T896 arg2Of genes7,selected
R727 T898 T897 arg1Of genes7,target
R728 T900 T899 arg1Of regulation,RPS3
R729 T900 T901 arg1Of regulation,of
R730 T906 T901 arg2Of processes,of
R731 T906 T902 arg1Of processes,NF-κB
R732 T906 T903 arg1Of processes,governs
R733 T906 T904 arg1Of processes,key
R734 T906 T905 arg1Of processes,physiological
R735 T906 T907 arg1Of processes,","
R736 T906 T908 arg1Of processes,including
R737 T914 T909 arg1Of expression,immunoglobulin
R738 T914 T910 arg1Of expression,κ
R739 T914 T911 arg1Of expression,light
R740 T914 T912 arg1Of expression,chain
R741 T914 T913 arg1Of expression,gene
R742 T914 T915 arg1Of expression,and
R743 T915 T908 arg2Of and,including
R744 T915 T918 arg1Of and,in
R745 T915 T929 arg1Of and,in
R746 T915 T938 arg1Of and,9
R747 T917 T915 arg2Of editing,and
R748 T917 T916 arg1Of editing,receptor
R749 T918 T928 arg1Of in,and
R750 T920 T918 arg2Of "cells6, 8",in
R751 T920 T919 arg1Of "cells6, 8",B
R752 T920 T921 arg1Of "cells6, 8",","
R753 T923 T921 arg2Of production,","
R754 T923 T922 arg1Of production,cytokine
R755 T923 T924 arg1Of production,in
R756 T926 T924 arg2Of cells6,in
R757 T926 T925 arg1Of cells6,T
R758 T928 T927 arg1Of and,","
R759 T929 T928 arg2Of in,and
R760 T931 T929 arg2Of defense,in
R761 T931 T930 arg1Of defense,host
R762 T931 T932 arg1Of defense,against
R763 T934 T932 arg2Of coli,against
R764 T934 T933 arg1Of coli,enterohemorrhagic Escherichia
R765 T934 T935 arg1Of coli,(
R766 T936 T935 arg2Of EHEC,(
R767 T937 T935 arg3Of ),(
R768 T940 T939 arg2Of particular,In
R769 T943 T942 arg1Of coli O157,the E.
R770 T943 T944 arg1Of coli O157,:
R771 T949 T944 arg2Of system,:
R772 T949 T945 arg1Of system,H7
R773 T949 T946 arg1Of system,type
R774 T949 T947 arg1Of system,III
R775 T949 T948 arg1Of system,secretion
R776 T949 T950 arg1Of system,(
R777 T951 T950 arg2Of T3SS,(
R778 T952 T950 arg3Of ),(
R779 T955 T953 arg1Of NleH1,effector
R780 T955 T954 arg1Of NleH1,protein
R781 T955 T957 arg1Of NleH1,blocks
R782 T955 T963 arg1Of NleH1,attenuating
R783 T957 T939 arg1Of blocks,In
R784 T957 T941 arg1Of blocks,","
R785 T957 T943 arg1Of blocks,coli O157
R786 T957 T956 arg1Of blocks,selectively
R787 T957 T962 arg1Of blocks,by
R788 T960 T958 arg1Of gene,NF-κB
R789 T960 T959 arg1Of gene,target
R790 T961 T957 arg2Of transcription,blocks
R791 T961 T960 arg1Of transcription,gene
R792 T963 T962 arg2Of attenuating,by
R793 T963 T967 arg1Of attenuating,","
R794 T963 T968 arg1Of attenuating,without
R795 T966 T963 arg2Of translocation,attenuating
R796 T966 T964 arg1Of translocation,RPS3
R797 T966 T965 arg1Of translocation,nuclear
R798 T969 T968 arg2Of affecting,without
R799 T971 T969 arg2Of localization9,affecting
R800 T971 T970 arg1Of localization9,p65
R801 T974 T983 arg1Of how,is
R802 T978 T975 arg1Of signals,specific
R803 T978 T976 arg1Of signals,NF-κB
R804 T978 T977 arg1Of signals,activating
R805 T978 T979 arg1Of signals,induce
R806 T979 T974 arg1Of induce,how
R807 T982 T979 arg2Of translocation,induce
R808 T982 T980 arg1Of translocation,RPS3
R809 T982 T981 arg1Of translocation,nuclear
R810 T983 T972 arg1Of is,Nonetheless
R811 T983 T973 arg1Of is,","
R812 T985 T984 arg1Of functions,"unknown. Extra-ribosomal"
R813 T985 T986 arg1Of functions,have
R814 T985 T987 arg1Of functions,been
R815 T985 T988 arg2Of functions,ascribed
R816 T988 T983 arg2Of ascribed,is
R817 T988 T986 arg2Of ascribed,have
R818 T988 T987 arg2Of ascribed,been
R819 T988 T989 arg1Of ascribed,to
R820 T991 T989 arg2Of proteins10,to
R821 T991 T990 arg1Of proteins10,ribosomal
R822 T994 T992 arg2Of RNA,Besides
R823 T994 T993 arg1Of RNA,binding
R824 T994 T995 arg1Of RNA,within
R825 T999 T995 arg2Of subunit,within
R826 T999 T996 arg1Of subunit,the
R827 T999 T997 arg1Of subunit,40S
R828 T999 T998 arg1Of subunit,ribosomal
R829 T1001 T1002 arg1Of RPS3,participates
R830 T1002 T992 arg1Of participates,Besides
R831 T1002 T1000 arg1Of participates,","
R832 T1002 T1003 arg1Of participates,in
R833 T1004 T1005 arg1Of transcription6,","
R834 T1005 T1009 arg1Of ",",and
R835 T1007 T1005 arg2Of "repair11, 12",","
R836 T1007 T1006 arg1Of "repair11, 12",DNA
R837 T1009 T1003 arg2Of and,in
R838 T1009 T1008 arg1Of and,","
R839 T1010 T1009 arg2Of apoptosis13,and
R840 T1014 T1012 arg1Of RPS3,or
R841 T1014 T1013 arg1Of RPS3,not
R842 T1014 T1015 arg1Of RPS3,is
R843 T1014 T1016 arg2Of RPS3,phosphorylated
R844 T1016 T1011 arg1Of phosphorylated,Whether
R845 T1016 T1015 arg2Of phosphorylated,is
R846 T1016 T1017 arg1Of phosphorylated,had
R847 T1016 T1018 arg1Of phosphorylated,been
R848 T1016 T1019 arg1Of phosphorylated,controversial14-18
R849 T1018 T1017 arg2Of been,had
R850 T1019 T1018 arg2Of controversial14-18,been
R851 T1022 T1021 arg1Of cascades,kinase
R852 T1022 T1023 arg1Of cascades,play
R853 T1023 T1020 arg2Of play,Since
R854 T1023 T1027 arg1Of play,in
R855 T1026 T1023 arg2Of role,play
R856 T1026 T1024 arg1Of role,a
R857 T1026 T1025 arg1Of role,critical
R858 T1029 T1027 arg2Of regulation,in
R859 T1029 T1028 arg1Of regulation,NF-κB
R860 T1031 T1032 arg1Of we,tested
R861 T1032 T1020 arg1Of tested,Since
R862 T1032 T1030 arg1Of tested,","
R863 T1034 T1035 arg1Of RPS3,is
R864 T1034 T1036 arg2Of RPS3,phosphorylated
R865 T1034 T1044 arg2Of RPS3,sought
R866 T1036 T1037 arg1Of phosphorylated,in
R867 T1036 T1043 arg1Of phosphorylated,and
R868 T1039 T1037 arg2Of context,in
R869 T1039 T1038 arg1Of context,the
R870 T1039 T1040 arg1Of context,of
R871 T1042 T1040 arg2Of activation,of
R872 T1042 T1041 arg1Of activation,NF-κB
R873 T1043 T1032 arg2Of and,tested
R874 T1043 T1033 arg1Of and,whether
R875 T1043 T1035 arg2Of and,is
R876 T1044 T1043 arg2Of sought,and
R877 T1046 T1044 arg3Of identify,sought
R878 T1046 T1045 arg1Of identify,to
R879 T1049 T1046 arg2Of kinase19,identify
R880 T1049 T1047 arg1Of kinase19,the
R881 T1049 T1048 arg1Of kinase19,responsible
R882 T1052 T1053 arg1Of we,aimed
R883 T1052 T1055 arg1Of we,define
R884 T1053 T1050 arg1Of aimed,Additionally
R885 T1053 T1051 arg1Of aimed,","
R886 T1055 T1053 arg2Of define,aimed
R887 T1055 T1054 arg1Of define,to
R888 T1058 T1055 arg2Of role,define
R889 T1058 T1056 arg1Of role,a
R890 T1058 T1057 arg1Of role,regulatory
R891 T1058 T1059 arg1Of role,for
R892 T1058 T1065 arg2Of role,whose
R893 T1062 T1059 arg2Of tail,for
R894 T1062 T1060 arg1Of tail,the
R895 T1062 T1061 arg1Of tail,C-terminal
R896 T1062 T1063 arg1Of tail,of
R897 T1064 T1063 arg2Of RPS3,of
R898 T1066 T1065 arg1Of function,whose
R899 T1066 T1067 arg1Of function,was
R900 T1066 T1068 arg1Of function,"unknown. Here"
R901 T1068 T1067 arg2Of "unknown. Here",was
R902 T1069 T1070 arg1Of we,show
R903 T1070 T1068 arg2Of show,"unknown. Here"
R904 T1071 T1070 arg2Of that,show
R905 T1073 T1070 arg3Of Inhibitor,show
R906 T1073 T1072 arg1Of Inhibitor,the
R907 T1073 T1074 arg1Of Inhibitor,of
R908 T1073 T1086 arg1Of Inhibitor,at
R909 T1077 T1076 arg2Of IκB,(
R910 T1078 T1076 arg3Of ),(
R911 T1080 T1075 arg1Of beta,κB
R912 T1080 T1076 arg1Of beta,(
R913 T1080 T1079 arg1Of beta,kinase
R914 T1080 T1081 arg1Of beta,(
R915 T1082 T1081 arg2Of IKKβ,(
R916 T1083 T1081 arg3Of ),(
R917 T1085 T1074 arg2Of RPS3,of
R918 T1085 T1080 arg1Of RPS3,beta
R919 T1085 T1084 arg2Of RPS3,phosphorylated
R920 T1087 T1086 arg2Of serine,at
R921 T1087 T1088 arg1Of serine,209
R922 T1087 T1089 arg1Of serine,(
R923 T1090 T1089 arg2Of S209,(
R924 T1091 T1089 arg3Of ),(
R925 T1094 T1092 arg1Of phosphorylation,RPS3
R926 T1094 T1093 arg1Of phosphorylation,S209
R927 T1094 T1095 arg1Of phosphorylation,enhanced
R928 T1095 T1100 arg1Of enhanced,","
R929 T1097 T1095 arg2Of association,enhanced
R930 T1097 T1096 arg1Of association,its
R931 T1097 T1098 arg1Of association,with
R932 T1099 T1098 arg2Of importin-α,with
R933 T1101 T1095 arg3Of mediating,enhanced
R934 T1103 T1101 arg2Of entry,mediating
R935 T1103 T1102 arg1Of entry,RPS3
R936 T1103 T1104 arg1Of entry,into
R937 T1107 T1104 arg2Of pathway,into
R938 T1107 T1105 arg1Of pathway,the
R939 T1107 T1106 arg1Of pathway,karyopherin
R940 T1107 T1108 arg1Of pathway,for
R941 T1110 T1108 arg2Of translocation,for
R942 T1110 T1109 arg1Of translocation,nuclear
R943 T1115 T1113 arg1Of effector,the E.
R944 T1115 T1114 arg1Of effector,coli NleH1
R945 T1115 T1117 arg1Of effector,inhibited
R946 T1117 T1111 arg1Of inhibited,Furthermore
R947 T1117 T1112 arg1Of inhibited,","
R948 T1117 T1116 arg1Of inhibited,specifically
R949 T1119 T1117 arg2Of S209,inhibited
R950 T1119 T1118 arg1Of S209,RPS3
R951 T1119 T1120 arg1Of S209,revealing
R952 T1122 T1120 arg2Of coli O157,revealing
R953 T1122 T1121 arg1Of coli O157,how E.
R954 T1122 T1123 arg1Of coli O157,:
R955 T1124 T1125 arg1Of H7,inhibits
R956 T1125 T1123 arg2Of inhibits,:
R957 T1131 T1125 arg2Of mechanism,inhibits
R958 T1131 T1126 arg1Of mechanism,this
R959 T1131 T1127 arg1Of mechanism,important
R960 T1131 T1128 arg1Of mechanism,innate
R961 T1131 T1129 arg1Of mechanism,immune
R962 T1131 T1130 arg1Of mechanism,response
R1587 T2018 T2017 arg1Of phosphorylation,RPS3
R1588 T2018 T2019 arg1Of phosphorylation,in
R1589 T2019 T2021 arg1Of in,to
R1590 T2020 T2019 arg2Of response,in
R1591 T2023 T2019 arg3Of activation,in
R1592 T2023 T2022 arg1Of activation,NF-κB
R1593 T2025 T2024 arg1Of test,To
R1594 T2027 T2028 arg1Of RPS3,is
R1595 T2027 T2029 arg2Of RPS3,phosphorylated
R1596 T2029 T2025 arg2Of phosphorylated,test
R1597 T2029 T2026 arg1Of phosphorylated,whether
R1598 T2029 T2028 arg2Of phosphorylated,is
R1599 T2029 T2030 arg1Of phosphorylated,during
R1600 T2032 T2030 arg2Of activation,during
R1601 T2032 T2031 arg1Of activation,NF-κB
R1602 T2034 T2025 arg1Of we,test
R1603 T2034 T2035 arg1Of we,performed
R1604 T2035 T2024 modOf performed,To
R1605 T2035 T2033 arg1Of performed,","
R1606 T2037 T2035 arg2Of experiments,performed
R1607 T2037 T2036 arg1Of experiments,32P-labeling
R1608 T2037 T2038 arg1Of experiments,in
R1609 T2043 T2042 arg2Of TNF,(
R1610 T2044 T2042 arg3Of ),(
R1611 T2048 T2038 arg2Of cells,in
R1612 T2048 T2039 arg1Of cells,tumor
R1613 T2048 T2040 arg1Of cells,necrosis
R1614 T2048 T2041 arg1Of cells,factor
R1615 T2048 T2042 arg1Of cells,(
R1616 T2048 T2045 arg1Of cells,-stimulated
R1617 T2048 T2046 arg1Of cells,HEK
R1618 T2048 T2047 arg1Of cells,293T
R1619 T2050 T2051 arg1Of RPS3,was
R1620 T2050 T2053 arg2Of RPS3,phosphorylated
R1621 T2053 T2049 arg2Of phosphorylated,While
R1622 T2053 T2051 arg2Of phosphorylated,was
R1623 T2053 T2052 arg1Of phosphorylated,scarcely
R1624 T2053 T2054 arg1Of phosphorylated,in
R1625 T2056 T2054 arg2Of cells,in
R1626 T2056 T2055 arg1Of cells,unstimulated
R1627 T2058 T2059 arg1Of we,observed
R1628 T2059 T2049 arg1Of observed,While
R1629 T2059 T2057 arg1Of observed,","
R1630 T2059 T2068 arg1Of observed,despite
R1631 T2062 T2059 arg2Of increase,observed
R1632 T2062 T2060 arg1Of increase,a
R1633 T2062 T2061 arg1Of increase,marked
R1634 T2062 T2063 arg1Of increase,in
R1635 T2062 T2065 arg1Of increase,after
R1636 T2064 T2063 arg2Of 32P-incorporation,in
R1637 T2067 T2065 arg2Of stimulation,after
R1638 T2067 T2066 arg1Of stimulation,TNF
R1639 T2070 T2068 arg2Of increase,despite
R1640 T2070 T2069 arg1Of increase,no
R1641 T2070 T2071 arg1Of increase,in
R1642 T2073 T2071 arg2Of protein,in
R1643 T2073 T2072 arg1Of protein,RPS3
R1644 T2073 T2074 arg1Of protein,(
R1645 T2076 T2074 arg2Of 1a,(
R1646 T2076 T2075 arg1Of 1a,Fig.
R1647 T2077 T2074 arg3Of ),(
R1648 T2079 T2078 arg1Of determine,To
R1649 T2080 T2079 arg2Of which,determine
R1650 T2082 T2080 arg1Of residues,which
R1651 T2082 T2081 arg1Of residues,RPS3
R1652 T2082 T2083 arg1Of residues,were
R1653 T2082 T2084 arg2Of residues,phosphorylated
R1654 T2084 T2083 arg2Of phosphorylated,were
R1655 T2086 T2087 arg1Of we,immunoprecipitated
R1656 T2087 T2078 modOf immunoprecipitated,To
R1657 T2087 T2085 arg1Of immunoprecipitated,","
R1658 T2088 T2087 arg2Of RPS3,immunoprecipitated
R1659 T2088 T2089 arg1Of RPS3,from
R1660 T2091 T2092 arg1Of resting,or
R1661 T2092 T2095 arg1Of or,and
R1662 T2094 T2092 arg2Of cells,or
R1663 T2094 T2093 arg2Of cells,stimulated
R1664 T2095 T2089 arg2Of and,from
R1665 T2095 T2090 arg1Of and,either
R1666 T2095 T2098 arg1Of and,with
R1667 T2097 T2095 arg2Of immunoblotting,and
R1668 T2097 T2096 arg2Of immunoblotting,performed
R1669 T2100 T2098 arg2Of antibodies,with
R1670 T2100 T2099 arg1Of antibodies,phosphorylation-specific
R1671 T2102 T2103 arg1Of TNF,and
R1672 T2103 T2101 arg1Of and,Both
R1673 T2103 T2110 arg1Of and,stimulated
R1674 T2106 T2103 arg2Of acetate/ionomycin,and
R1675 T2106 T2104 arg1Of acetate/ionomycin,phorbol
R1676 T2106 T2105 arg1Of acetate/ionomycin,myristate
R1677 T2106 T2107 arg1Of acetate/ionomycin,(
R1678 T2108 T2107 arg2Of PMA+I,(
R1679 T2109 T2107 arg3Of ),(
R1680 T2110 T2117 arg1Of stimulated,within
R1681 T2112 T2111 arg1Of phosphorylation,rapid
R1682 T2112 T2113 arg1Of phosphorylation,and
R1683 T2113 T2110 arg2Of and,stimulated
R1684 T2114 T2113 arg2Of degradaion,and
R1685 T2114 T2115 arg1Of degradaion,of
R1686 T2116 T2115 arg2Of IκBα,of
R1687 T2119 T2117 arg2Of min,within
R1688 T2119 T2118 arg1Of min,5
R1689 T2119 T2120 arg1Of min,which
R1690 T2119 T2121 arg1Of min,was
R1691 T2119 T2122 arg2Of min,accompanied
R1692 T2122 T2121 arg2Of accompanied,was
R1693 T2125 T2122 arg1Of phosphorylation,accompanied
R1694 T2125 T2123 arg2Of phosphorylation,by
R1695 T2125 T2124 arg1Of phosphorylation,RPS3
R1696 T2125 T2126 arg1Of phosphorylation,on
R1697 T2128 T2126 arg2Of residues,on
R1698 T2128 T2127 arg1Of residues,serine
R1699 T2128 T2129 arg1Of residues,(
R1700 T2128 T2137 arg1Of residues,","
R1701 T2128 T2138 arg1Of residues,similar
R1702 T2131 T2130 arg1Of 1b,Fig.
R1703 T2131 T2132 arg1Of 1b,and
R1704 T2132 T2129 arg2Of and,(
R1705 T2133 T2132 arg2Of data,and
R1706 T2133 T2135 arg2Of data,shown
R1707 T2135 T2134 arg1Of shown,not
R1708 T2136 T2129 arg3Of ),(
R1709 T2138 T2139 arg1Of similar,to
R1710 T2142 T2141 arg1Of vivo,in
R1711 T2143 T2139 arg2Of labeling,to
R1712 T2143 T2140 arg1Of labeling,the
R1713 T2143 T2142 arg1Of labeling,vivo
R1714 T2144 T2145 arg1Of We,did
R1715 T2144 T2147 arg1Of We,detect
R1716 T2147 T2145 arg2Of detect,did
R1717 T2147 T2146 arg1Of detect,not
R1718 T2148 T2149 arg1Of tyrosine-,or
R1719 T2149 T2147 arg2Of or,detect
R1720 T2149 T2151 arg1Of or,of
R1721 T2150 T2149 arg2Of threonine-phosphorylation,or
R1722 T2152 T2151 arg2Of RPS3,of
R1723 T2152 T2153 arg1Of RPS3,(
R1724 T2155 T2153 arg2Of 1b,(
R1725 T2155 T2154 arg1Of 1b,Fig.
R1726 T2156 T2153 arg3Of ),(
R2062 T2641 T2642 arg1Of RPS3,and
R2063 T2643 T2642 arg2Of IKKβ,and
R2064 T2644 T2641 arg1Of interaction,RPS3
R2065 T2644 T2643 arg1Of interaction,IKKβ
R2066 T2646 T2645 arg1Of activation,The
R2067 T2646 T2647 arg1Of activation,of
R2068 T2646 T2656 arg1Of activation,","
R2069 T2646 T2657 arg1Of activation,consisting
R2070 T2646 T2672 arg1Of activation,is
R2071 T2646 T2673 arg1Of activation,critical
R2072 T2649 T2647 arg2Of inhibitor,of
R2073 T2649 T2648 arg1Of inhibitor,the
R2074 T2649 T2650 arg1Of inhibitor,of
R2075 T2652 T2650 arg2Of kinase,of
R2076 T2652 T2651 arg1Of kinase,κB
R2077 T2652 T2653 arg1Of kinase,(
R2078 T2654 T2653 arg2Of IKK,(
R2079 T2655 T2653 arg3Of ),(
R2080 T2657 T2658 arg1Of consisting,of
R2081 T2662 T2659 arg1Of IKKγ,a
R2082 T2662 T2660 arg1Of IKKγ,regulatory
R2083 T2662 T2661 arg1Of IKKγ,subunit
R2084 T2662 T2663 arg1Of IKKγ,and
R2085 T2663 T2658 arg2Of and,of
R2086 T2663 T2667 arg1Of and,","
R2087 T2666 T2663 arg2Of subunits,and
R2088 T2666 T2664 arg1Of subunits,two
R2089 T2666 T2665 arg1Of subunits,catalytic
R2090 T2668 T2669 arg1Of IKKα,and
R2091 T2669 T2667 arg2Of and,","
R2092 T2670 T2669 arg2Of IKKβ,and
R2093 T2672 T2671 arg1Of is,","
R2094 T2673 T2672 arg2Of critical,is
R2095 T2673 T2674 arg1Of critical,for
R2096 T2676 T2677 arg1Of phosphorylation,and
R2097 T2677 T2675 arg1Of and,the
R2098 T2677 T2679 arg1Of and,of
R2099 T2677 T2683 arg1Of and,and
R2100 T2678 T2677 arg2Of dispatch,and
R2101 T2682 T2679 arg2Of IκBs,of
R2102 T2682 T2680 arg1Of IκBs,the
R2103 T2682 T2681 arg1Of IκBs,inhibitory
R2104 T2683 T2674 arg2Of and,for
R2105 T2685 T2683 arg2Of liberation,and
R2106 T2685 T2684 arg1Of liberation,the
R2107 T2685 T2686 arg1Of liberation,of
R2108 T2687 T2686 arg2Of NF-κB20-22,of
R2109 T2690 T2688 arg2Of RPS3,Given
R2110 T2690 T2689 arg1Of RPS3,that
R2111 T2690 T2691 arg1Of RPS3,can
R2112 T2690 T2692 arg1Of RPS3,be
R2113 T2690 T2693 arg2Of RPS3,found
R2114 T2693 T2691 arg2Of found,can
R2115 T2693 T2692 arg2Of found,be
R2116 T2693 T2694 arg1Of found,in
R2117 T2693 T2703 arg1Of found,","
R2118 T2699 T2694 arg2Of complex,in
R2119 T2699 T2695 arg1Of complex,the
R2120 T2699 T2696 arg1Of complex,cytoplasmic
R2121 T2699 T2697 arg1Of complex,p65-p50-IκBα
R2122 T2699 T2698 arg1Of complex,inhibitory
R2123 T2699 T2700 arg1Of complex,in
R2124 T2702 T2700 arg2Of cells6,in
R2125 T2702 T2701 arg1Of cells6,resting
R2126 T2704 T2705 arg1Of we,hypothesized
R2127 T2705 T2703 arg2Of hypothesized,","
R2128 T2708 T2707 arg2Of IKKβ,activated
R2129 T2708 T2709 arg1Of IKKβ,might
R2130 T2708 T2711 arg1Of IKKβ,bind
R2131 T2708 T2714 arg1Of IKKβ,phosphorylate
R2132 T2711 T2712 arg1Of bind,to
R2133 T2711 T2713 arg1Of bind,and
R2134 T2713 T2705 arg2Of and,hypothesized
R2135 T2713 T2706 arg1Of and,that
R2136 T2713 T2709 arg2Of and,might
R2137 T2713 T2710 arg1Of and,also
R2138 T2714 T2713 arg2Of phosphorylate,and
R2139 T2715 T2714 arg2Of RPS3,phosphorylate
R2140 T2718 T2719 arg1Of we,found
R2141 T2719 T2716 arg1Of found,First
R2142 T2719 T2717 arg1Of found,","
R2143 T2722 T2721 arg1Of expressed,ectopically
R2144 T2723 T2724 arg1Of IKKβ,and
R2145 T2724 T2722 arg1Of and,expressed
R2146 T2724 T2726 arg1Of and,interacted
R2147 T2725 T2724 arg2Of RPS3,and
R2148 T2726 T2719 arg2Of interacted,found
R2149 T2726 T2720 arg1Of interacted,that
R2150 T2726 T2727 arg1Of interacted,(
R2151 T2729 T2727 arg2Of 1c,(
R2152 T2729 T2728 arg1Of 1c,Fig.
R2153 T2730 T2727 arg3Of ),(
R2154 T2731 T2733 arg1Of We,examined
R2155 T2731 T2738 arg1Of We,detected
R2156 T2731 T2750 arg1Of We,accounting
R2157 T2733 T2737 arg1Of examined,and
R2158 T2736 T2733 arg2Of cells,examined
R2159 T2736 T2734 arg1Of cells,resting
R2160 T2736 T2735 arg1Of cells,Jurkat
R2161 T2737 T2732 arg1Of and,next
R2162 T2737 T2748 arg1Of and,","
R2163 T2737 T2750 modOf and,accounting
R2164 T2738 T2737 arg2Of detected,and
R2165 T2743 T2738 arg2Of interaction,detected
R2166 T2743 T2739 arg1Of interaction,a
R2167 T2743 T2740 arg1Of interaction,modest
R2168 T2743 T2741 arg1Of interaction,endogenous
R2169 T2743 T2742 arg1Of interaction,IKKβ-RPS3
R2170 T2743 T2744 arg1Of interaction,(
R2171 T2746 T2744 arg2Of 1d,(
R2172 T2746 T2745 arg1Of 1d,Fig.
R2173 T2747 T2744 arg3Of ),(
R2174 T2750 T2749 arg1Of accounting,potentially
R2175 T2750 T2751 arg1Of accounting,for
R2176 T2755 T2751 arg2Of transcription,for
R2177 T2755 T2752 arg1Of transcription,the
R2178 T2755 T2753 arg1Of transcription,basal
R2179 T2755 T2754 arg1Of transcription,NF-κB
R2180 T2755 T2756 arg2Of transcription,required
R2181 T2756 T2757 arg1Of required,for
R2182 T2759 T2760 arg1Of proliferation,and
R2183 T2760 T2757 arg2Of and,for
R2184 T2760 T2758 arg1Of and,cell
R2185 T2761 T2760 arg2Of survival,and
R2186 T2763 T2762 arg1Of association,RPS3-IKKβ
R2187 T2763 T2764 arg1Of association,was
R2188 T2763 T2766 arg2Of association,augmented
R2189 T2763 T2771 arg1Of association,peaking
R2190 T2766 T2764 arg2Of augmented,was
R2191 T2766 T2765 arg1Of augmented,clearly
R2192 T2766 T2767 arg1Of augmented,upon
R2193 T2766 T2770 arg1Of augmented,","
R2194 T2766 T2771 modOf augmented,peaking
R2195 T2766 T2779 arg1Of augmented,","
R2196 T2766 T2780 arg1Of augmented,following
R2197 T2769 T2767 arg2Of stimulation,upon
R2198 T2769 T2768 arg1Of stimulation,TNF
R2199 T2771 T2772 arg1Of peaking,at
R2200 T2774 T2772 arg2Of min.,at
R2201 T2774 T2773 arg1Of min.,10
R2202 T2774 T2775 arg1Of min.,(
R2203 T2777 T2775 arg2Of 1d,(
R2204 T2777 T2776 arg1Of 1d,Fig.
R2205 T2778 T2775 arg3Of ),(
R2206 T2782 T2780 arg2Of kinetics,following
R2207 T2782 T2781 arg1Of kinetics,similar
R2208 T2782 T2783 arg1Of kinetics,to
R2209 T2786 T2783 arg2Of phosphorylation,to
R2210 T2786 T2784 arg1Of phosphorylation,RPS3
R2211 T2786 T2785 arg1Of phosphorylation,serine
R2212 T2786 T2787 arg1Of phosphorylation,(
R2213 T2789 T2787 arg2Of 1b,(
R2214 T2789 T2788 arg1Of 1b,Fig.
R2215 T2790 T2787 arg3Of ),(
R2216 T2792 T2791 arg2Of contrast,By
R2217 T2794 T2795 arg1Of there,was
R2218 T2795 T2791 arg1Of was,By
R2219 T2795 T2793 arg1Of was,","
R2220 T2798 T2795 arg2Of interaction,was
R2221 T2798 T2796 arg1Of interaction,no
R2222 T2798 T2797 arg1Of interaction,detectable
R2223 T2798 T2799 arg1Of interaction,between
R2224 T2800 T2801 arg1Of RPS3,and
R2225 T2801 T2799 arg2Of and,between
R2226 T2801 T2803 arg1Of and,(
R2227 T2802 T2801 arg2Of IKKα,and
R2228 T2805 T2803 arg2Of 1d,(
R2229 T2805 T2804 arg1Of 1d,Fig.
R2230 T2806 T2803 arg3Of ),(
R2766 T3544 T3545 arg1Of IKKβ,is
R2767 T3544 T3546 arg2Of IKKβ,required
R2768 T3546 T3545 arg2Of required,is
R2769 T3546 T3547 arg1Of required,for
R2770 T3550 T3547 arg2Of translocation,for
R2771 T3550 T3548 arg1Of translocation,RPS3
R2772 T3550 T3549 arg1Of translocation,nuclear
R2773 T3552 T3551 arg1Of examine,To
R2774 T3556 T3554 arg1Of interaction,the
R2775 T3556 T3555 arg1Of interaction,RPS3-IKKβ
R2776 T3556 T3557 arg1Of interaction,is
R2777 T3556 T3558 arg2Of interaction,required
R2778 T3558 T3552 arg2Of required,examine
R2779 T3558 T3553 arg1Of required,whether
R2780 T3558 T3557 arg2Of required,is
R2781 T3558 T3559 arg1Of required,for
R2782 T3562 T3559 arg2Of translocation,for
R2783 T3562 T3560 arg1Of translocation,RPS3
R2784 T3562 T3561 arg1Of translocation,nuclear
R2785 T3564 T3552 arg1Of we,examine
R2786 T3564 T3565 arg1Of we,knocked
R2787 T3565 T3551 modOf knocked,To
R2788 T3565 T3563 arg1Of knocked,","
R2789 T3565 T3566 arg1Of knocked,down
R2790 T3567 T3568 arg1Of IKKα,or
R2791 T3568 T3565 arg2Of or,knocked
R2792 T3568 T3571 arg1Of or,with
R2793 T3570 T3568 arg2Of expression,or
R2794 T3570 T3569 arg1Of expression,IKKβ
R2795 T3572 T3573 arg1Of siRNAs,(
R2796 T3572 T3578 arg1Of siRNAs,and
R2797 T3575 T3573 arg2Of Fig.,(
R2798 T3575 T3574 arg1Of Fig.,Supplementary
R2799 T3575 T3576 arg1Of Fig.,1
R2800 T3577 T3573 arg3Of ),(
R2801 T3578 T3571 arg2Of and,with
R2802 T3580 T3579 arg1Of observed,then
R2803 T3584 T3578 arg2Of migration,and
R2804 T3584 T3580 arg1Of migration,observed
R2805 T3584 T3581 arg1Of migration,stimulation-induced
R2806 T3584 T3582 arg1Of migration,RPS3
R2807 T3584 T3583 arg1Of migration,nuclear
R2808 T3584 T3585 arg1Of migration,by
R2809 T3587 T3585 arg2Of microscopy,by
R2810 T3587 T3586 arg1Of microscopy,confocal
R2811 T3589 T3590 arg1Of TNF,and
R2812 T3590 T3588 arg1Of and,Both
R2813 T3590 T3592 arg1Of and,triggered
R2814 T3591 T3590 arg2Of PMA+I,and
R2815 T3595 T3592 arg2Of translocation,triggered
R2816 T3595 T3593 arg1Of translocation,RPS3
R2817 T3595 T3594 arg1Of translocation,nuclear
R2818 T3595 T3596 arg1Of translocation,in
R2819 T3598 T3596 arg2Of cells,in
R2820 T3598 T3597 arg1Of cells,Jurkat
R2821 T3598 T3599 arg2Of cells,transfected
R2822 T3599 T3600 arg1Of transfected,with
R2823 T3605 T3604 arg2Of NS,(
R2824 T3606 T3604 arg3Of ),(
R2825 T3607 T3600 arg2Of siRNA,with
R2826 T3607 T3601 arg1Of siRNA,a
R2827 T3607 T3602 arg2Of siRNA,scrambled
R2828 T3607 T3603 arg1Of siRNA,nonspecific
R2829 T3607 T3604 arg1Of siRNA,(
R2830 T3607 T3608 arg1Of siRNA,(
R2831 T3607 T3612 arg1Of siRNA,6
R2832 T3610 T3608 arg2Of 2a,(
R2833 T3610 T3609 arg1Of 2a,Fig.
R2834 T3611 T3608 arg3Of ),(
R2835 T3615 T3613 arg1Of translocation,RPS3
R2836 T3615 T3614 arg1Of translocation,nuclear
R2837 T3615 T3616 arg1Of translocation,was
R2838 T3615 T3624 arg2Of translocation,impaired
R2839 T3618 T3617 arg1Of slightly,only
R2840 T3618 T3620 arg1Of slightly,if
R2841 T3620 T3619 arg1Of if,","
R2842 T3621 T3620 arg2Of at,if
R2843 T3621 T3622 arg1Of at,all
R2844 T3624 T3616 arg2Of impaired,was
R2845 T3624 T3618 arg1Of impaired,slightly
R2846 T3624 T3621 arg1Of impaired,at
R2847 T3624 T3623 arg1Of impaired,","
R2848 T3626 T3624 arg1Of IKKα-silencing,impaired
R2849 T3626 T3625 arg2Of IKKα-silencing,by
R2850 T3629 T3630 arg1Of knockdown,of
R2851 T3629 T3632 arg1Of knockdown,attenuated
R2852 T3631 T3630 arg2Of IKKβ,of
R2853 T3632 T3627 arg1Of attenuated,Conversely
R2854 T3632 T3628 arg1Of attenuated,","
R2855 T3632 T3639 arg1Of attenuated,following
R2856 T3634 T3632 arg2Of %,attenuated
R2857 T3634 T3633 arg1Of %,60-70
R2858 T3634 T3635 arg1Of %,of
R2859 T3638 T3635 arg2Of accumulation,of
R2860 T3638 T3636 arg1Of accumulation,RPS3
R2861 T3638 T3637 arg1Of accumulation,nuclear
R2862 T3640 T3639 arg2Of stimulation,following
R2863 T3640 T3641 arg1Of stimulation,(
R2864 T3643 T3641 arg2Of 2a,(
R2865 T3643 T3642 arg1Of 2a,Fig.
R2866 T3644 T3641 arg3Of ),(
R2867 T3645 T3646 arg1Of Immunoblotting,of
R2868 T3645 T3649 arg1Of Immunoblotting,confirmed
R2869 T3648 T3646 arg2Of fractions,of
R2870 T3648 T3647 arg1Of fractions,nuclear
R2871 T3652 T3651 arg1Of expression,full
R2872 T3652 T3653 arg1Of expression,of
R2873 T3652 T3660 arg1Of expression,was
R2874 T3652 T3661 arg1Of expression,necessary
R2875 T3654 T3656 arg1Of IKKβ,but
R2876 T3656 T3653 arg2Of but,of
R2877 T3656 T3655 arg1Of but,","
R2878 T3656 T3657 arg1Of but,not
R2879 T3658 T3656 arg2Of IKKα,but
R2880 T3660 T3649 arg2Of was,confirmed
R2881 T3660 T3650 arg1Of was,that
R2882 T3660 T3659 arg1Of was,","
R2883 T3661 T3660 arg2Of necessary,was
R2884 T3661 T3662 arg1Of necessary,for
R2885 T3666 T3662 arg2Of translocation,for
R2886 T3666 T3663 arg1Of translocation,activation-induced
R2887 T3666 T3664 arg1Of translocation,RPS3
R2888 T3666 T3665 arg1Of translocation,nuclear
R2889 T3666 T3667 arg1Of translocation,(
R2890 T3669 T3667 arg2Of 2b,(
R2891 T3669 T3668 arg1Of 2b,Fig.
R2892 T3670 T3667 arg3Of ),(
R2893 T3672 T3671 arg1Of immunoblots,Control
R2894 T3672 T3673 arg1Of immunoblots,revealed
R2895 T3677 T3675 arg1Of translocation,p65
R2896 T3677 T3676 arg1Of translocation,nuclear
R2897 T3677 T3678 arg1Of translocation,was
R2898 T3677 T3679 arg2Of translocation,blocked
R2899 T3679 T3673 arg2Of blocked,revealed
R2900 T3679 T3674 arg1Of blocked,that
R2901 T3679 T3678 arg2Of blocked,was
R2902 T3679 T3680 arg1Of blocked,under
R2903 T3679 T3684 arg1Of blocked,(
R2904 T3683 T3680 arg2Of conditions,under
R2905 T3683 T3681 arg1Of conditions,the
R2906 T3683 T3682 arg1Of conditions,same
R2907 T3686 T3684 arg2Of 2b,(
R2908 T3686 T3685 arg1Of 2b,Fig.
R2909 T3687 T3684 arg3Of ),(
R2910 T3688 T3690 arg1Of We,examined
R2911 T3690 T3689 arg1Of examined,next
R2912 T3693 T3690 arg2Of translocation,examined
R2913 T3693 T3691 arg1Of translocation,the
R2914 T3693 T3692 arg1Of translocation,nuclear
R2915 T3693 T3694 arg1Of translocation,of
R2916 T3693 T3696 arg1Of translocation,in
R2917 T3695 T3694 arg2Of RPS3,of
R2918 T3697 T3699 arg1Of cells,expressing
R2919 T3697 T3705 arg1Of cells,or
R2920 T3699 T3698 arg1Of expressing,ectopically
R2921 T3701 T3699 arg2Of kinase-dead,expressing
R2922 T3701 T3700 arg1Of kinase-dead,either
R2923 T3701 T3702 arg1Of kinase-dead,(
R2924 T3703 T3702 arg2Of SSAA,(
R2925 T3704 T3702 arg3Of ),(
R2926 T3705 T3696 arg2Of or,in
R2927 T3708 T3707 arg2Of SSEE,(
R2928 T3709 T3707 arg3Of ),(
R2929 T3712 T3705 arg2Of proteins,or
R2930 T3712 T3706 arg1Of proteins,constitutively-active
R2931 T3712 T3707 arg1Of proteins,(
R2932 T3712 T3710 arg1Of proteins,mutant
R2933 T3712 T3711 arg1Of proteins,IKKβ
R2934 T3714 T3713 arg2Of expected,As
R2935 T3717 T3719 arg1Of SSEE,but
R2936 T3719 T3718 arg1Of but,","
R2937 T3719 T3720 arg1Of but,not
R2938 T3719 T3722 arg1Of but,","
R2939 T3721 T3719 arg2Of SSAA,but
R2940 T3722 T3716 arg1Of ",",the
R2941 T3722 T3724 arg1Of ",",of
R2942 T3722 T3726 arg1Of ",",induced
R2943 T3723 T3722 arg2Of mutant,","
R2944 T3725 T3724 arg2Of IKKβ,of
R2945 T3726 T3713 arg1Of induced,As
R2946 T3726 T3715 arg1Of induced,","
R2947 T3726 T3731 arg1Of induced,(
R2948 T3730 T3726 arg2Of activity,induced
R2949 T3730 T3727 arg1Of activity,NF-κB-dependent
R2950 T3730 T3728 arg1Of activity,luciferase
R2951 T3730 T3729 arg1Of activity,reporter
R2952 T3733 T3731 arg2Of 2c,(
R2953 T3733 T3732 arg1Of 2c,Fig.
R2954 T3733 T3734 arg1Of 2c,","
R2955 T3735 T3734 arg2Of left,","
R2956 T3736 T3731 arg3Of ),(
R2957 T3738 T3739 arg1Of RPS3,remained
R2958 T3739 T3737 arg2Of remained,Whereas
R2959 T3740 T3741 arg1Of cytosolic,in
R2960 T3742 T3741 arg2Of IKKβ,in
R2961 T3742 T3743 arg1Of IKKβ,(
R2962 T3744 T3743 arg2Of SSAA,(
R2963 T3745 T3743 arg3Of ),(
R2964 T3747 T3739 arg2Of cells,remained
R2965 T3747 T3740 arg1Of cells,cytosolic
R2966 T3747 T3746 arg1Of cells,-expressing
R2967 T3747 T3748 arg1Of cells,(
R2968 T3747 T3754 arg1Of cells,","
R2969 T3750 T3748 arg2Of 2c,(
R2970 T3750 T3749 arg1Of 2c,Fig.
R2971 T3750 T3751 arg1Of 2c,","
R2972 T3752 T3751 arg2Of right,","
R2973 T3753 T3748 arg3Of ),(
R2974 T3757 T3754 arg2Of proportion,","
R2975 T3757 T3755 arg1Of proportion,a
R2976 T3757 T3756 arg1Of proportion,substantial
R2977 T3757 T3758 arg1Of proportion,of
R2978 T3759 T3758 arg2Of RPS3,of
R2979 T3759 T3760 arg2Of RPS3,translocated
R2980 T3760 T3761 arg1Of translocated,to
R2981 T3763 T3761 arg2Of nucleus,to
R2982 T3763 T3762 arg1Of nucleus,the
R2983 T3763 T3764 arg1Of nucleus,in
R2984 T3765 T3764 arg2Of cells,in
R2985 T3765 T3766 arg1Of cells,expressing
R2986 T3767 T3766 arg2Of IKKβ,expressing
R2987 T3767 T3768 arg1Of IKKβ,(
R2988 T3767 T3771 arg1Of IKKβ,(
R2989 T3769 T3768 arg2Of SSEE,(
R2990 T3770 T3768 arg3Of ),(
R2991 T3773 T3771 arg2Of 2c,(
R2992 T3773 T3772 arg1Of 2c,Fig.
R2993 T3773 T3774 arg1Of 2c,","
R2994 T3775 T3774 arg2Of right,","
R2995 T3776 T3771 arg3Of ),(
R2996 T3778 T3777 arg1Of percentage,The
R2997 T3778 T3779 arg1Of percentage,of
R2998 T3778 T3785 arg1Of percentage,increased
R2999 T3780 T3779 arg2Of cells,of
R3000 T3780 T3781 arg1Of cells,containing
R3001 T3784 T3781 arg2Of RPS3,containing
R3002 T3784 T3782 arg1Of RPS3,detectable
R3003 T3784 T3783 arg1Of RPS3,nuclear
R3004 T3785 T3786 arg1Of increased,5-fold
R3005 T3785 T3787 arg1Of increased,in
R3006 T3785 T3797 arg1Of increased,in
R3007 T3785 T3804 arg1Of increased,(
R3008 T3787 T3795 arg1Of in,but
R3009 T3790 T3789 arg2Of SSEE,(
R3010 T3791 T3789 arg3Of ),(
R3011 T3793 T3787 arg2Of cells,in
R3012 T3793 T3788 arg1Of cells,IKKβ
R3013 T3793 T3789 arg1Of cells,(
R3014 T3793 T3792 arg1Of cells,-expressing
R3015 T3795 T3794 arg1Of but,","
R3016 T3797 T3795 arg2Of in,but
R3017 T3797 T3796 arg1Of in,not
R3018 T3800 T3799 arg2Of SSAA,(
R3019 T3801 T3799 arg3Of ),(
R3020 T3803 T3797 arg2Of ones,in
R3021 T3803 T3798 arg1Of ones,IKKβ
R3022 T3803 T3799 arg1Of ones,(
R3023 T3803 T3802 arg1Of ones,-expressing
R3024 T3805 T3806 arg1Of Fig.,2d
R3025 T3805 T3807 arg1Of Fig.,and
R3026 T3807 T3804 arg2Of and,(
R3027 T3809 T3807 arg2Of Fig.,and
R3028 T3809 T3808 arg1Of Fig.,Supplementary
R3029 T3809 T3810 arg1Of Fig.,2
R3030 T3811 T3804 arg3Of ),(
R3031 T3815 T3814 arg1Of activity,IKKβ
R3032 T3815 T3816 arg1Of activity,is
R3033 T3815 T3817 arg1Of activity,necessary
R3034 T3815 T3819 arg1Of activity,sufficient
R3035 T3816 T3812 arg1Of is,Thus
R3036 T3816 T3813 arg1Of is,","
R3037 T3817 T3818 arg1Of necessary,and
R3038 T3818 T3816 arg2Of and,is
R3039 T3818 T3820 arg1Of and,for
R3040 T3819 T3818 arg2Of sufficient,and
R3041 T3823 T3820 arg2Of translocation,for
R3042 T3823 T3821 arg1Of translocation,RPS3
R3043 T3823 T3822 arg1Of translocation,nuclear
R3044 T3823 T3824 arg1Of translocation,in
R3045 T3825 T3824 arg2Of response,in
R3046 T3825 T3826 arg1Of response,to
R3047 T3829 T3826 arg2Of stimuli,to
R3048 T3829 T3827 arg1Of stimuli,NF-κB
R3049 T3829 T3828 arg1Of stimuli,activating
R4092 T5161 T5160 arg1Of degradation,IκBα
R4093 T5161 T5162 arg1Of degradation,and
R4094 T5165 T5162 arg2Of translocation,and
R4095 T5165 T5163 arg1Of translocation,RPS3
R4096 T5165 T5164 arg1Of translocation,nuclear
R4097 T5166 T5167 arg1Of Importin-α,regulates
R4100 T5170 T5167 arg2Of import,regulates
R4101 T5170 T5168 arg1Of import,the
R4102 T5174 T5171 arg2Of subunits23,of
R4103 T5174 T5172 arg1Of subunits23,NF-κB
R4104 T5174 T5173 arg1Of subunits23,Rel
R4105 T5174 T5175 arg1Of subunits23,","
R4106 T5176 T5175 arg2Of 24,","
R4107 T5177 T5178 arg1Of RPS3,harbors
R4108 T5178 T5187 arg1Of harbors,and
R4109 T5182 T5180 arg1Of signal,nuclear
R4110 T5182 T5181 arg1Of signal,localization
R4111 T5182 T5183 arg1Of signal,(
R4112 T5184 T5183 arg2Of NLS,(
R4113 T5185 T5183 arg3Of ),(
R4114 T5186 T5178 arg2Of sequence,harbors
R4115 T5186 T5179 arg1Of sequence,a
R4116 T5186 T5182 arg1Of sequence,signal
R4117 T5190 T5188 arg1Of translocation,its
R4118 T5190 T5189 arg1Of translocation,nuclear
R4119 T5190 T5191 arg1Of translocation,occurs
R4120 T5191 T5187 arg2Of occurs,and
R4121 T5191 T5192 arg1Of occurs,in
R4122 T5191 T5194 arg1Of occurs,to
R4123 T5191 T5198 arg1Of occurs,of
R4124 T5193 T5192 arg2Of parallel,in
R4125 T5194 T5196 arg1Of to,but
R4126 T5196 T5195 arg1Of but,","
R4127 T5198 T5196 arg2Of of,but
R4128 T5198 T5197 arg1Of of,independently
R4129 T5198 T5199 arg1Of of,","
R4130 T5201 T5198 arg2Of translocation6,of
R4131 T5201 T5200 arg1Of translocation6,p65
R4132 T5202 T5203 arg1Of We,envisioned
R4133 T5205 T5206 arg1Of RPS3,could
R4134 T5205 T5208 arg1Of RPS3,utilize
R4135 T5208 T5203 arg2Of utilize,envisioned
R4136 T5208 T5204 arg1Of utilize,that
R4137 T5208 T5206 arg2Of utilize,could
R4138 T5208 T5207 arg1Of utilize,also
R4139 T5211 T5208 arg2Of pathway,utilize
R4140 T5211 T5209 arg1Of pathway,the
R4141 T5211 T5210 arg1Of pathway,importin-α/β
R4142 T5212 T5213 arg1Of Consistent,with
R4143 T5215 T5213 arg2Of notion,with
R4144 T5215 T5214 arg1Of notion,this
R4145 T5218 T5217 arg1Of association,RPS3
R4146 T5218 T5219 arg1Of association,with
R4147 T5218 T5226 arg1Of association,was
R4148 T5218 T5227 arg2Of association,enhanced
R4149 T5220 T5222 arg1Of importin-α,but
R4150 T5222 T5219 arg2Of but,with
R4151 T5222 T5221 arg1Of but,","
R4152 T5222 T5223 arg1Of but,not
R4153 T5224 T5222 arg2Of importin-β,but
R4154 T5227 T5212 arg1Of enhanced,Consistent
R4155 T5227 T5216 arg1Of enhanced,","
R4156 T5227 T5225 arg1Of enhanced,","
R4157 T5227 T5226 arg2Of enhanced,was
R4158 T5227 T5228 arg1Of enhanced,in
R4159 T5230 T5228 arg2Of cells,in
R4160 T5230 T5229 arg2Of cells,TNF–stimulated
R4161 T5230 T5231 arg1Of cells,(
R4162 T5233 T5231 arg2Of 3a,(
R4163 T5233 T5232 arg1Of 3a,Fig.
R4164 T5234 T5231 arg3Of ),(
R4165 T5237 T5238 arg1Of we,examined
R4166 T5238 T5235 arg1Of examined,Therefore
R4167 T5238 T5236 arg1Of examined,","
R4168 T5241 T5240 arg1Of binding,RPS3
R4169 T5241 T5242 arg1Of binding,to
R4170 T5241 T5244 arg1Of binding,is
R4171 T5241 T5245 arg1Of binding,essential
R4172 T5243 T5242 arg2Of importin-α,to
R4173 T5244 T5238 arg2Of is,examined
R4174 T5244 T5239 arg1Of is,whether
R4175 T5245 T5244 arg2Of essential,is
R4176 T5245 T5246 arg1Of essential,for
R4177 T5245 T5249 arg1Of essential,during
R4178 T5248 T5246 arg2Of translocation,for
R4179 T5248 T5247 arg1Of translocation,nuclear
R4180 T5251 T5249 arg2Of activation,during
R4181 T5251 T5250 arg1Of activation,NF-κB
R4182 T5254 T5253 arg1Of degradation,IκBα
R4183 T5254 T5255 arg1Of degradation,is
R4184 T5255 T5265 arg1Of is,and
R4185 T5257 T5255 arg2Of prerequisite,is
R4186 T5257 T5256 arg1Of prerequisite,a
R4187 T5257 T5258 modOf prerequisite,to
R4188 T5259 T5258 arg1Of unmask,to
R4189 T5261 T5259 arg2Of NLS,unmask
R4190 T5261 T5260 arg1Of NLS,the
R4191 T5261 T5262 arg1Of NLS,of
R4192 T5263 T5262 arg2Of p65,of
R4193 T5265 T5252 arg2Of and,Since
R4194 T5265 T5264 arg1Of and,","
R4195 T5267 T5268 arg1Of RPS3,and
R4196 T5268 T5266 arg1Of and,both
R4197 T5268 T5270 arg1Of and,bind
R4198 T5269 T5268 arg2Of IκBα,and
R4199 T5270 T5265 arg2Of bind,and
R4200 T5270 T5271 arg1Of bind,to
R4201 T5270 T5273 arg1Of bind,in
R4202 T5272 T5271 arg2Of p65,to
R4203 T5277 T5273 arg2Of complex,in
R4204 T5277 T5274 arg1Of complex,the
R4205 T5277 T5275 arg1Of complex,cytoplasmic
R4206 T5277 T5276 arg1Of complex,inhibitory
R4207 T5279 T5280 arg1Of we,tested
R4208 T5280 T5252 arg1Of tested,Since
R4209 T5280 T5278 arg1Of tested,","
R4210 T5283 T5282 arg1Of degradation,IκBα
R4211 T5283 T5284 arg1Of degradation,is
R4212 T5283 T5285 arg2Of degradation,required
R4213 T5285 T5280 arg2Of required,tested
R4214 T5285 T5281 arg1Of required,whether
R4215 T5285 T5284 arg2Of required,is
R4216 T5285 T5286 arg1Of required,for
R4217 T5288 T5286 arg2Of liberation,for
R4218 T5288 T5287 arg1Of liberation,the
R4219 T5288 T5289 arg1Of liberation,of
R4220 T5290 T5289 arg2Of RPS3,of
R4221 T5291 T5292 arg1Of We,measured
R4222 T5294 T5293 arg1Of association,the
R4223 T5294 T5295 arg1Of association,of
R4224 T5294 T5297 arg1Of association,with
R4225 T5294 T5299 arg1Of association,in
R4226 T5294 T5305 arg1Of association,or
R4227 T5296 T5295 arg2Of RPS3,of
R4228 T5298 T5297 arg2Of importin-α,with
R4229 T5301 T5299 arg2Of cells,in
R4230 T5301 T5300 arg1Of cells,293T
R4231 T5301 T5302 arg1Of cells,overexpressing
R4232 T5304 T5302 arg2Of IκBα,overexpressing
R4233 T5304 T5303 arg1Of IκBα,wild-type
R4234 T5305 T5292 arg2Of or,measured
R4235 T5308 T5305 arg2Of mutant,or
R4236 T5308 T5306 arg1Of mutant,an
R4237 T5308 T5307 arg1Of mutant,IκBα
R4238 T5308 T5309 arg1Of mutant,(
R4239 T5308 T5312 arg1Of mutant,resistant
R4240 T5310 T5309 arg2Of SSAA,(
R4241 T5311 T5309 arg3Of ),(
R4242 T5312 T5313 arg1Of resistant,to
R4243 T5315 T5316 arg1Of phosphorylation,and
R4244 T5316 T5313 arg2Of and,to
R4245 T5316 T5314 arg1Of and,IKKβ-induced
R4246 T5317 T5316 arg2Of degradation,and
R4247 T5319 T5318 arg2Of cells,In
R4248 T5319 T5320 arg2Of cells,transfected
R4249 T5320 T5321 arg1Of transfected,with
R4250 T5323 T5321 arg2Of IκBα,with
R4251 T5323 T5322 arg1Of IκBα,wild-type
R4252 T5326 T5325 arg1Of stimulation,TNF
R4253 T5326 T5327 arg1Of stimulation,augmented
R4254 T5327 T5318 arg1Of augmented,In
R4255 T5327 T5324 arg1Of augmented,","
R4256 T5329 T5327 arg2Of interaction,augmented
R4257 T5329 T5328 arg1Of interaction,the
R4258 T5329 T5330 arg1Of interaction,of
R4259 T5331 T5332 arg1Of RPS3,and
R4260 T5333 T5332 arg2Of importin-α,and
R4261 T5333 T5334 arg1Of importin-α,to
R4262 T5333 T5339 arg1Of importin-α,in
R4263 T5337 T5334 arg2Of degree,to
R4264 T5337 T5335 arg1Of degree,a
R4265 T5337 T5336 arg1Of degree,similar
R4266 T5339 T5338 arg1Of in,as
R4267 T5340 T5339 arg2Of non-transfected,in
R4268 T5341 T5330 arg2Of cells,of
R4269 T5341 T5331 arg1Of cells,RPS3
R4270 T5341 T5333 arg1Of cells,importin-α
R4271 T5343 T5342 arg2Of contrast,By
R4272 T5345 T5346 arg1Of we,observed
R4273 T5346 T5342 arg1Of observed,By
R4274 T5346 T5344 arg1Of observed,","
R4275 T5350 T5348 arg1Of association,the
R4276 T5350 T5349 arg1Of association,RPS3-importin-α
R4277 T5350 T5351 arg1Of association,was
R4278 T5350 T5352 arg2Of association,abolished
R4279 T5352 T5346 arg2Of abolished,observed
R4280 T5352 T5347 arg1Of abolished,that
R4281 T5352 T5351 arg2Of abolished,was
R4282 T5355 T5352 arg1Of presence,abolished
R4283 T5355 T5353 arg2Of presence,by
R4284 T5355 T5354 arg1Of presence,the
R4285 T5355 T5356 arg1Of presence,of
R4286 T5358 T5356 arg2Of IκBα,of
R4287 T5358 T5357 arg1Of IκBα,non-degradable
R4288 T5358 T5359 arg1Of IκBα,(
R4289 T5361 T5359 arg2Of 3b,(
R4290 T5361 T5360 arg1Of 3b,Fig.
R4291 T5362 T5359 arg3Of ),(
R4292 T5364 T5363 arg1Of examine,To
R4293 T5366 T5367 arg1Of IκBα,is
R4294 T5367 T5364 arg2Of is,examine
R4295 T5367 T5365 arg1Of is,whether
R4296 T5371 T5367 arg2Of barrier,is
R4297 T5371 T5368 arg1Of barrier,the
R4298 T5371 T5369 arg1Of barrier,only
R4299 T5371 T5370 arg1Of barrier,cytoplasmic
R4300 T5371 T5372 arg1Of barrier,precluding
R4301 T5375 T5372 arg2Of translocation,precluding
R4302 T5375 T5373 arg1Of translocation,RPS3
R4303 T5375 T5374 arg1Of translocation,nuclear
R4304 T5377 T5364 arg1Of we,examine
R4305 T5377 T5378 arg1Of we,measured
R4306 T5377 T5386 arg1Of we,reducing
R4307 T5378 T5363 modOf measured,To
R4308 T5378 T5376 arg1Of measured,","
R4309 T5378 T5385 arg1Of measured,after
R4310 T5381 T5380 arg1Of association,RPS3-importin-α
R4311 T5381 T5382 arg1Of association,and
R4312 T5382 T5378 arg2Of and,measured
R4313 T5382 T5379 arg1Of and,both
R4314 T5384 T5382 arg2Of RPS3,and
R4315 T5384 T5383 arg1Of RPS3,nuclear
R4316 T5386 T5385 arg2Of reducing,after
R4317 T5388 T5386 arg2Of expression,reducing
R4318 T5388 T5387 arg1Of expression,IκBα
R4319 T5390 T5389 arg2Of with,Compared
R4320 T5392 T5390 arg2Of siRNA,with
R4321 T5392 T5391 arg1Of siRNA,nonspecific
R4322 T5395 T5394 arg1Of targeting,siRNA
R4323 T5395 T5396 arg1Of targeting,of
R4324 T5395 T5399 arg1Of targeting,depleted
R4325 T5397 T5396 arg2Of IκBα,of
R4326 T5399 T5389 arg1Of depleted,Compared
R4327 T5399 T5393 arg1Of depleted,","
R4328 T5399 T5398 arg1Of depleted,completely
R4329 T5399 T5401 arg1Of depleted,in
R4330 T5400 T5399 arg2Of IκBα,depleted
R4331 T5403 T5401 arg2Of cells,in
R4332 T5403 T5402 arg1Of cells,Jurkat
R4333 T5403 T5404 arg1Of cells,(
R4334 T5406 T5404 arg2Of 3c,(
R4335 T5406 T5405 arg1Of 3c,Fig.
R4336 T5406 T5407 arg1Of 3c,","
R4337 T5408 T5407 arg2Of input,","
R4338 T5409 T5404 arg3Of ),(
R4339 T5414 T5412 arg1Of association,the
R4340 T5414 T5413 arg1Of association,RPS3-importin-α
R4341 T5414 T5415 arg1Of association,was
R4342 T5414 T5417 arg1Of association,augmented
R4343 T5414 T5424 arg1Of association,was
R4344 T5415 T5416 arg1Of was,not
R4345 T5415 T5423 arg1Of was,nor
R4346 T5417 T5415 arg2Of augmented,was
R4347 T5417 T5418 arg1Of augmented,(
R4348 T5420 T5418 arg2Of 3c,(
R4349 T5420 T5419 arg1Of 3c,Fig.
R4350 T5421 T5418 arg3Of ),(
R4351 T5423 T5410 arg1Of nor,Nevertheless
R4352 T5423 T5411 arg1Of nor,","
R4353 T5423 T5422 arg1Of nor,","
R4354 T5424 T5423 arg2Of was,nor
R4355 T5426 T5425 arg1Of nuclear,significant
R4356 T5427 T5424 arg2Of RPS3,was
R4357 T5427 T5426 arg1Of RPS3,nuclear
R4358 T5427 T5428 arg2Of RPS3,detected
R4359 T5428 T5429 arg1Of detected,(
R4360 T5431 T5429 arg2Of 3d,(
R4361 T5431 T5430 arg1Of 3d,Fig.
R4362 T5432 T5429 arg3Of ),(
R4363 T5435 T5436 arg2Of cells,treated
R4364 T5435 T5451 arg1Of cells,did
R4365 T5435 T5453 arg1Of cells,show
R4366 T5436 T5437 arg1Of treated,with
R4367 T5439 T5437 arg2Of pervanadate,with
R4368 T5439 T5438 arg1Of pervanadate,sodium
R4369 T5439 T5440 arg1Of pervanadate,(
R4370 T5439 T5443 modOf pervanadate,to
R4371 T5441 T5440 arg2Of Pv,(
R4372 T5442 T5440 arg3Of ),(
R4373 T5444 T5443 arg1Of induce,to
R4374 T5444 T5447 arg1Of induce,through
R4375 T5446 T5444 arg2Of degradation,induce
R4376 T5446 T5445 arg1Of degradation,IκBα
R4377 T5450 T5447 arg2Of mechanism25-27,through
R4378 T5450 T5448 arg1Of mechanism25-27,an
R4379 T5450 T5449 arg1Of mechanism25-27,IKK-independent
R4380 T5453 T5433 arg1Of show,Moreover
R4381 T5453 T5434 arg1Of show,","
R4382 T5453 T5451 arg2Of show,did
R4383 T5453 T5452 arg1Of show,not
R4384 T5453 T5473 arg1Of show,","
R4385 T5453 T5474 arg1Of show,despite
R4386 T5455 T5453 arg2Of association,show
R4387 T5455 T5454 arg2Of association,increased
R4388 T5455 T5456 arg1Of association,between
R4389 T5457 T5458 arg1Of RPS3,and
R4390 T5458 T5456 arg2Of and,between
R4391 T5459 T5460 arg1Of importin-α,(
R4392 T5459 T5468 arg1Of importin-α,or
R4393 T5462 T5461 arg1Of 3e,Fig.
R4394 T5462 T5463 arg1Of 3e,and
R4395 T5463 T5460 arg2Of and,(
R4396 T5465 T5464 arg1Of Fig.,Supplementary
R4397 T5466 T5463 arg2Of 3b,and
R4398 T5466 T5465 arg1Of 3b,Fig.
R4399 T5467 T5460 arg3Of ),(
R4400 T5468 T5458 arg2Of or,and
R4401 T5470 T5468 arg2Of accumulation,or
R4402 T5470 T5469 arg1Of accumulation,nuclear
R4403 T5470 T5471 arg1Of accumulation,of
R4404 T5472 T5471 arg2Of RPS3,of
R4405 T5477 T5474 arg2Of degradation,despite
R4406 T5477 T5475 arg1Of degradation,complete
R4407 T5477 T5476 arg1Of degradation,IκBα
R4408 T5477 T5478 arg1Of degradation,(
R4409 T5480 T5479 arg1Of Fig.,Supplementary
R4410 T5481 T5478 arg2Of 3c,(
R4411 T5481 T5480 arg1Of 3c,Fig.
R4412 T5482 T5478 arg3Of ),(
R4413 T5483 T5485 arg1Of We,examined
R4414 T5485 T5484 arg1Of examined,further
R4415 T5491 T5487 arg1Of signal,a
R4416 T5491 T5488 arg1Of signal,subsequent
R4417 T5491 T5489 arg1Of signal,NF-κB
R4418 T5491 T5490 arg1Of signal,activation
R4419 T5491 T5493 arg1Of signal,promotes
R4420 T5493 T5485 arg2Of promotes,examined
R4421 T5493 T5486 arg1Of promotes,whether
R4422 T5493 T5492 arg1Of promotes,independently
R4423 T5493 T5502 arg1Of promotes,after
R4424 T5496 T5494 arg1Of association,the
R4425 T5496 T5495 arg1Of association,importin-α
R4426 T5496 T5497 arg1Of association,and
R4427 T5497 T5493 arg2Of and,promotes
R4428 T5499 T5497 arg2Of transport,and
R4429 T5499 T5498 arg1Of transport,nuclear
R4430 T5499 T5500 arg1Of transport,of
R4431 T5501 T5500 arg2Of RPS3,of
R4432 T5504 T5502 arg2Of degradation,after
R4433 T5504 T5503 arg1Of degradation,IκBα
R4434 T5505 T5506 arg1Of We,found
R4435 T5509 T5508 arg1Of stimulation,TNF
R4436 T5509 T5510 arg1Of stimulation,following
R4437 T5509 T5513 arg1Of stimulation,was
R4438 T5509 T5514 arg2Of stimulation,required
R4439 T5512 T5510 arg2Of treatment,following
R4440 T5512 T5511 arg1Of treatment,Pv
R4441 T5514 T5506 arg2Of required,found
R4442 T5514 T5507 arg1Of required,that
R4443 T5514 T5513 arg2Of required,was
R4444 T5514 T5515 arg1Of required,for
R4445 T5518 T5515 arg2Of association,for
R4446 T5518 T5516 arg1Of association,the
R4447 T5518 T5517 arg1Of association,RPS3-importin-α
R4448 T5518 T5519 arg1Of association,","
R4449 T5518 T5520 arg1Of association,comparable
R4450 T5520 T5521 arg1Of comparable,to
R4451 T5523 T5521 arg2Of stimulation,to
R4452 T5523 T5522 arg1Of stimulation,TNF
R4453 T5523 T5524 arg1Of stimulation,alone
R4454 T5523 T5525 arg1Of stimulation,(
R4455 T5527 T5525 arg2Of 3e,(
R4456 T5527 T5526 arg1Of 3e,Fig.
R4457 T5528 T5525 arg3Of ),(
R4458 T5532 T5531 arg1Of phosphorylation,IκBα
R4459 T5532 T5533 arg1Of phosphorylation,and
R4460 T5533 T5536 arg1Of and,is
R4461 T5533 T5537 arg2Of and,required
R4462 T5533 T5540 arg1Of and,sufficient
R4463 T5534 T5533 arg2Of degradation,and
R4464 T5534 T5535 arg1Of degradation,itself
R4465 T5537 T5538 arg1Of required,but
R4466 T5538 T5529 arg1Of but,Thus
R4467 T5538 T5530 arg1Of but,","
R4468 T5538 T5536 arg2Of but,is
R4469 T5538 T5541 modOf but,to
R4470 T5540 T5538 arg2Of sufficient,but
R4471 T5540 T5539 arg1Of sufficient,not
R4472 T5542 T5541 arg1Of cause,to
R4473 T5544 T5542 arg2Of association,cause
R4474 T5544 T5543 arg1Of association,RPS3
R4475 T5544 T5545 arg1Of association,with
R4476 T5546 T5545 arg2Of importin-α,with
R4477 T5546 T5547 arg2Of importin-α,followed
R4478 T5550 T5547 arg1Of translocation,followed
R4479 T5550 T5548 arg2Of translocation,by
R4480 T5550 T5549 arg1Of translocation,nuclear
R4481 T5555 T5553 arg1Of signal,an
R4482 T5555 T5554 arg1Of signal,additional
R4483 T5555 T5556 arg1Of signal,","
R4484 T5555 T5563 arg1Of signal,is
R4485 T5555 T5564 arg2Of signal,required
R4486 T5559 T5556 arg2Of phosphorylation,","
R4487 T5559 T5557 arg1Of phosphorylation,potentially
R4488 T5559 T5558 arg1Of phosphorylation,IKKβ
R4489 T5559 T5560 arg1Of phosphorylation,of
R4490 T5561 T5560 arg2Of RPS3,of
R4491 T5564 T5551 arg1Of required,Rather
R4492 T5564 T5552 arg1Of required,","
R4493 T5564 T5562 arg1Of required,","
R4494 T5564 T5563 arg2Of required,is
R5650 T7159 T7160 arg1Of IKKβ,phosphorylates
R5651 T7161 T7160 arg2Of RPS3,phosphorylates
R5652 T7161 T7162 arg1Of RPS3,at
R5653 T7163 T7162 arg2Of serine,at
R5654 T7163 T7164 arg1Of serine,209
R5655 T7167 T7165 arg2Of defined,Although
R5656 T7167 T7166 arg1Of defined,originally
R5657 T7167 T7168 arg1Of defined,as
R5658 T7170 T7168 arg2Of kinase,as
R5659 T7170 T7169 arg1Of kinase,the
R5660 T7170 T7171 arg1Of kinase,that
R5661 T7170 T7172 arg1Of kinase,phosphorylates
R5662 T7173 T7172 arg2Of IκB19,phosphorylates
R5663 T7175 T7177 arg1Of IKKβ,phosphorylates
R5664 T7177 T7165 arg1Of phosphorylates,Although
R5665 T7177 T7174 arg1Of phosphorylates,","
R5666 T7177 T7176 arg1Of phosphorylates,also
R5667 T7179 T7177 arg2Of substrates,phosphorylates
R5668 T7179 T7178 arg1Of substrates,unrelated
R5669 T7179 T7180 arg1Of substrates,including
R5670 T7181 T7182 arg1Of 14-3-3β,and
R5671 T7182 T7180 arg2Of and,including
R5672 T7182 T7184 arg1Of and,","
R5673 T7182 T7185 arg1Of and,which
R5674 T7182 T7186 arg1Of and,lack
R5675 T7183 T7182 arg2Of Bcl10,and
R5676 T7190 T7186 arg2Of motif,lack
R5677 T7190 T7187 arg1Of motif,the
R5678 T7190 T7188 arg1Of motif,IKK
R5679 T7190 T7189 arg1Of motif,consensus
R5680 T7190 T7191 arg1Of motif,(
R5681 T7190 T7194 arg1Of motif,28
R5682 T7192 T7191 arg2Of DpSGYXpS/T,(
R5683 T7193 T7191 arg3Of ),(
R5684 T7195 T7197 arg1Of We,hypothesized
R5685 T7197 T7196 arg1Of hypothesized,therefore
R5686 T7199 T7200 arg1Of IKKβ,could
R5687 T7199 T7202 arg1Of IKKβ,phosphorylate
R5688 T7202 T7197 arg2Of phosphorylate,hypothesized
R5689 T7202 T7198 arg1Of phosphorylate,that
R5690 T7202 T7200 arg2Of phosphorylate,could
R5691 T7202 T7201 arg1Of phosphorylate,directly
R5692 T7203 T7202 arg2Of RPS3,phosphorylate
R5693 T7206 T7205 arg1Of vitro,in
R5694 T7208 T7204 arg2Of assays,By
R5695 T7208 T7206 arg1Of assays,vitro
R5696 T7208 T7207 arg1Of assays,kinase
R5697 T7208 T7209 arg1Of assays,using
R5698 T7211 T7212 arg1Of IKK,and
R5699 T7213 T7212 arg2Of RPS3,and
R5700 T7214 T7209 arg2Of proteins,using
R5701 T7214 T7210 arg1Of proteins,recombinant
R5702 T7214 T7211 arg1Of proteins,IKK
R5703 T7214 T7213 arg1Of proteins,RPS3
R5704 T7216 T7217 arg1Of we,observed
R5705 T7217 T7204 arg1Of observed,By
R5706 T7217 T7215 arg1Of observed,","
R5707 T7217 T7263 arg1Of observed,","
R5708 T7217 T7264 arg1Of observed,when
R5709 T7219 T7218 arg1Of incorporation,strong
R5710 T7219 T7220 arg1Of incorporation,of
R5711 T7219 T7222 arg1Of incorporation,in
R5712 T7219 T7225 arg1Of incorporation,and
R5713 T7221 T7220 arg2Of 32P,of
R5714 T7224 T7222 arg2Of IKKα,in
R5715 T7224 T7223 arg1Of IKKα,autophosphorylatd
R5716 T7225 T7236 arg1Of and,as
R5717 T7226 T7225 arg2Of IKKβ,and
R5718 T7226 T7227 arg1Of IKKβ,(
R5719 T7229 T7227 arg2Of 4a,(
R5720 T7229 T7228 arg1Of 4a,Fig.
R5721 T7229 T7230 arg1Of 4a,","
R5722 T7231 T7230 arg2Of lanes,","
R5723 T7231 T7232 arg1Of lanes,2-7
R5724 T7233 T7227 arg3Of ),(
R5725 T7236 T7217 arg2Of as,observed
R5726 T7236 T7234 arg1Of as,as
R5727 T7236 T7235 arg1Of as,well
R5728 T7238 T7237 arg2Of GST-IκBα,phosporylated
R5729 T7238 T7239 arg1Of GST-IκBα,(
R5730 T7238 T7242 arg1Of GST-IκBα,(
R5731 T7238 T7248 arg1Of GST-IκBα,but
R5732 T7240 T7239 arg2Of 1-54,(
R5733 T7241 T7239 arg3Of ),(
R5734 T7244 T7242 arg2Of Fig.,(
R5735 T7244 T7243 arg1Of Fig.,Supplementary
R5736 T7244 T7245 arg1Of Fig.,4
R5737 T7246 T7242 arg3Of ),(
R5738 T7248 T7236 arg2Of but,as
R5739 T7248 T7247 arg1Of but,","
R5740 T7248 T7249 arg1Of but,not
R5741 T7252 T7248 arg2Of protein,but
R5742 T7252 T7250 arg1Of protein,the
R5743 T7252 T7251 arg1Of protein,GST
R5744 T7252 T7253 arg1Of protein,alone
R5745 T7252 T7254 arg1Of protein,(
R5746 T7256 T7255 arg1Of 4a,Fig.
R5747 T7256 T7257 arg1Of 4a,","
R5748 T7257 T7254 arg2Of ",",(
R5749 T7259 T7260 arg1Of 3,and
R5750 T7260 T7257 arg2Of and,","
R5751 T7260 T7258 arg1Of and,lanes
R5752 T7261 T7260 arg2Of 6,and
R5753 T7262 T7254 arg3Of ),(
R5754 T7266 T7267 arg1Of IKKα,or
R5755 T7267 T7265 arg1Of or,either
R5756 T7267 T7269 arg1Of or,was
R5757 T7267 T7270 arg2Of or,used
R5758 T7268 T7267 arg2Of IKKβ,or
R5759 T7270 T7264 arg2Of used,when
R5760 T7270 T7269 arg2Of used,was
R5761 T7271 T7272 arg1Of We,discovered
R5762 T7274 T7275 arg1Of GST-RPS3,could
R5763 T7274 T7276 arg1Of GST-RPS3,be
R5764 T7274 T7277 arg2Of GST-RPS3,phosphorylated
R5765 T7277 T7272 arg2Of phosphorylated,discovered
R5766 T7277 T7273 arg1Of phosphorylated,that
R5767 T7277 T7275 arg2Of phosphorylated,could
R5768 T7277 T7276 arg2Of phosphorylated,be
R5769 T7279 T7281 arg1Of IKKβ,but
R5770 T7281 T7277 arg1Of but,phosphorylated
R5771 T7281 T7278 arg2Of but,by
R5772 T7281 T7280 arg1Of but,","
R5773 T7281 T7282 arg1Of but,not
R5774 T7281 T7284 arg1Of but,","
R5775 T7281 T7286 arg1Of but,vitro
R5776 T7281 T7287 arg1Of but,(
R5777 T7283 T7281 arg2Of IKKα,but
R5778 T7286 T7285 arg1Of vitro,in
R5779 T7289 T7287 arg2Of 4a,(
R5780 T7289 T7288 arg1Of 4a,Fig.
R5781 T7289 T7290 arg1Of 4a,","
R5782 T7293 T7294 arg1Of 4,and
R5783 T7294 T7290 arg2Of and,","
R5784 T7294 T7291 arg1Of and,compare
R5785 T7294 T7292 arg1Of and,lanes
R5786 T7295 T7294 arg2Of 7,and
R5787 T7296 T7287 arg3Of ),(
R5788 T7298 T7297 arg1Of identify,To
R5789 T7303 T7298 arg2Of residue,identify
R5790 T7303 T7299 arg1Of residue,the
R5791 T7303 T7300 arg1Of residue,RPS3
R5792 T7303 T7301 arg1Of residue,amino
R5793 T7303 T7302 arg1Of residue,acid
R5794 T7303 T7304 arg1Of residue,(
R5795 T7303 T7307 arg2Of residue,phosphorylated
R5796 T7305 T7304 arg2Of s,(
R5797 T7306 T7304 arg3Of ),(
R5798 T7309 T7307 arg1Of IKKβ,phosphorylated
R5799 T7309 T7308 arg2Of IKKβ,by
R5800 T7311 T7298 arg1Of we,identify
R5801 T7311 T7312 arg1Of we,performed
R5802 T7312 T7297 modOf performed,To
R5803 T7312 T7310 arg1Of performed,","
R5804 T7317 T7312 arg2Of analyses,performed
R5805 T7317 T7313 arg1Of analyses,liquid
R5806 T7317 T7314 arg1Of analyses,chromatography-tandem
R5807 T7317 T7315 arg1Of analyses,mass
R5808 T7317 T7316 arg1Of analyses,spectrometry
R5809 T7317 T7318 arg1Of analyses,using
R5810 T7318 T7320 arg1Of using,vitro
R5811 T7320 T7319 arg1Of vitro,in
R5812 T7322 T7318 arg2Of RPS3,using
R5813 T7322 T7321 arg2Of RPS3,phosphorylated
R5814 T7324 T7325 arg1Of results,indicated
R5815 T7327 T7325 arg2Of IKKβ,indicated
R5816 T7327 T7326 arg1Of IKKβ,that
R5817 T7328 T7325 arg3Of phosphorylated,indicated
R5818 T7329 T7323 arg1Of S209,The
R5819 T7329 T7328 arg2Of S209,phosphorylated
R5820 T7329 T7330 arg1Of S209,","
R5821 T7329 T7331 arg1Of S209,located
R5822 T7331 T7332 arg1Of located,in
R5823 T7335 T7332 arg2Of C-terminus,in
R5824 T7335 T7333 arg1Of C-terminus,the
R5825 T7335 T7334 arg1Of C-terminus,RPS3
R5826 T7335 T7336 arg1Of C-terminus,(
R5827 T7338 T7336 arg2Of 4b,(
R5828 T7338 T7337 arg1Of 4b,Fig.
R5829 T7339 T7336 arg3Of ),(
R5830 T7344 T7340 arg1Of alignment,RPS3
R5831 T7344 T7341 arg1Of alignment,amino
R5832 T7344 T7342 arg1Of alignment,acid
R5833 T7344 T7343 arg1Of alignment,sequence
R5834 T7344 T7345 arg1Of alignment,revealed
R5835 T7347 T7348 arg1Of S209,is
R5836 T7347 T7349 arg2Of S209,conserved
R5837 T7349 T7345 arg2Of conserved,revealed
R5838 T7349 T7346 arg1Of conserved,that
R5839 T7349 T7348 arg2Of conserved,is
R5840 T7349 T7350 arg1Of conserved,in
R5841 T7349 T7353 arg1Of conserved,throughout
R5842 T7352 T7350 arg2Of species,in
R5843 T7352 T7351 arg1Of species,many
R5844 T7354 T7353 arg2Of phylogeny,throughout
R5845 T7354 T7355 arg1Of phylogeny,with
R5846 T7357 T7355 arg2Of exception,with
R5847 T7357 T7356 arg1Of exception,the
R5848 T7357 T7358 arg1Of exception,of
R5849 T7357 T7364 arg1Of exception,","
R5850 T7360 T7359 arg1Of elegans,Caenorhabditis
R5851 T7360 T7361 arg1Of elegans,and
R5852 T7361 T7358 arg2Of and,of
R5853 T7363 T7361 arg2Of pombe,and
R5854 T7363 T7362 arg1Of pombe,Schizosaccharomyces
R5855 T7366 T7364 arg2Of organisms,","
R5856 T7366 T7365 arg1Of organisms,two
R5857 T7366 T7367 arg1Of organisms,that
R5858 T7366 T7368 arg1Of organisms,do
R5859 T7366 T7370 arg1Of organisms,possess
R5860 T7370 T7368 arg2Of possess,do
R5861 T7370 T7369 arg1Of possess,not
R5862 T7370 T7375 arg1Of possess,(
R5863 T7374 T7370 arg2Of pathway,possess
R5864 T7374 T7371 arg1Of pathway,the
R5865 T7374 T7372 arg1Of pathway,NF-κB
R5866 T7374 T7373 arg1Of pathway,signal
R5867 T7377 T7375 arg2Of Fig.,(
R5868 T7377 T7376 arg1Of Fig.,Supplementary
R5869 T7377 T7378 arg1Of Fig.,5
R5870 T7379 T7375 arg3Of ),(
R5871 T7381 T7380 arg1Of verify,To
R5872 T7381 T7382 arg1Of verify,biochemically
R5873 T7384 T7385 arg1Of S209,is
R5874 T7385 T7381 arg2Of is,verify
R5875 T7385 T7383 arg1Of is,that
R5876 T7388 T7385 arg2Of substrate,is
R5877 T7388 T7386 arg1Of substrate,an
R5878 T7388 T7387 arg1Of substrate,IKKβ
R5879 T7390 T7381 arg1Of we,verify
R5880 T7390 T7391 arg1Of we,performed
R5881 T7391 T7380 modOf performed,To
R5882 T7391 T7389 arg1Of performed,","
R5883 T7394 T7393 arg1Of vitro,in
R5884 T7396 T7391 arg2Of assays,performed
R5885 T7396 T7392 arg1Of assays,32P-labeling
R5886 T7396 T7394 arg1Of assays,vitro
R5887 T7396 T7395 arg1Of assays,kinase
R5888 T7396 T7397 arg1Of assays,with
R5889 T7399 T7398 arg1Of wild-type,recombinant
R5890 T7399 T7400 arg1Of wild-type,or
R5891 T7400 T7397 arg2Of or,with
R5892 T7404 T7400 arg2Of proteins,or
R5893 T7404 T7401 arg1Of proteins,S209A
R5894 T7404 T7402 arg1Of proteins,mutant
R5895 T7404 T7403 arg1Of proteins,RPS3
R5896 T7406 T7405 arg2Of with,Compared
R5897 T7409 T7406 arg2Of protein,with
R5898 T7409 T7407 arg1Of protein,the
R5899 T7409 T7408 arg1Of protein,wild-type
R5900 T7413 T7411 arg1Of mutation,the
R5901 T7413 T7412 arg1Of mutation,S209A
R5902 T7413 T7414 arg1Of mutation,reduced
R5903 T7414 T7405 arg1Of reduced,Compared
R5904 T7414 T7410 arg1Of reduced,","
R5905 T7417 T7414 arg2Of phosphorylation,reduced
R5906 T7417 T7415 arg1Of phosphorylation,IKKβ–mediated
R5907 T7417 T7416 arg1Of phosphorylation,RPS3
R5908 T7417 T7418 arg1Of phosphorylation,(
R5909 T7420 T7418 arg2Of 4c,(
R5910 T7420 T7419 arg1Of 4c,Fig.
R5911 T7421 T7418 arg3Of ),(
R5912 T7422 T7423 arg1Of There,might
R5913 T7422 T7424 arg1Of There,be
R5914 T7424 T7423 arg2Of be,might
R5915 T7424 T7431 arg1Of be,under
R5916 T7424 T7434 arg1Of be,given
R5917 T7427 T7424 arg2Of site,be
R5918 T7427 T7425 arg1Of site,alternative
R5919 T7427 T7426 arg1Of site,phosphorylation
R5920 T7427 T7428 arg1Of site,(
R5921 T7429 T7428 arg2Of s,(
R5922 T7430 T7428 arg3Of ),(
R5923 T7433 T7431 arg2Of conditions,under
R5924 T7433 T7432 arg1Of conditions,these
R5925 T7438 T7434 arg2Of RPS3,given
R5926 T7438 T7435 arg1Of RPS3,modest
R5927 T7438 T7436 arg1Of RPS3,residual
R5928 T7438 T7437 arg2Of RPS3,phosphorylated
R5929 T7438 T7439 arg1Of RPS3,(
R5930 T7441 T7439 arg2Of 4c,(
R5931 T7441 T7440 arg1Of 4c,Fig.
R5932 T7442 T7439 arg3Of ),(
R5933 T7444 T7443 arg1Of S209,RPS3
R5934 T7444 T7445 arg1Of S209,does
R5935 T7444 T7447 arg1Of S209,fall
R5936 T7444 T7457 arg1Of S209,resides
R5937 T7447 T7445 arg2Of fall,does
R5938 T7447 T7446 arg1Of fall,not
R5939 T7447 T7448 arg1Of fall,within
R5940 T7447 T7455 arg1Of fall,but
R5941 T7453 T7448 arg2Of motif,within
R5942 T7453 T7449 arg1Of motif,a
R5943 T7453 T7450 arg1Of motif,conventional
R5944 T7453 T7451 arg1Of motif,IKK
R5945 T7453 T7452 arg1Of motif,recognition
R5946 T7455 T7454 arg1Of but,","
R5947 T7457 T7455 arg2Of resides,but
R5948 T7457 T7456 arg1Of resides,rather
R5949 T7457 T7458 arg1Of resides,in
R5950 T7461 T7458 arg2Of motif,in
R5951 T7461 T7459 arg1Of motif,a
R5952 T7461 T7460 arg1Of motif,sequence
R5953 T7461 T7462 arg1Of motif,(
R5954 T7461 T7465 arg1Of motif,","
R5955 T7461 T7467 arg2Of motif,recognized
R5956 T7463 T7462 arg2Of XXXpS/TXXE,(
R5957 T7464 T7462 arg3Of ),(
R5958 T7467 T7466 arg1Of recognized,potentially
R5959 T7470 T7467 arg1Of kinase,recognized
R5960 T7470 T7468 arg2Of kinase,by
R5961 T7470 T7469 arg1Of kinase,casein
R5962 T7470 T7471 arg1Of kinase,II
R5963 T7470 T7472 arg1Of kinase,(
R5964 T7473 T7472 arg2Of CK2,(
R5965 T7474 T7472 arg3Of ),(
R5966 T7477 T7476 arg1Of kinase,IKKβ
R5967 T7477 T7478 arg1Of kinase,can
R5968 T7477 T7479 arg1Of kinase,display
R5969 T7479 T7475 arg2Of display,Although
R5970 T7479 T7478 arg2Of display,can
R5971 T7483 T7479 arg2Of specificity29,display
R5972 T7483 T7480 arg1Of specificity29,a
R5973 T7483 T7481 arg1Of specificity29,CK2-like
R5974 T7483 T7482 arg1Of specificity29,phosphorylation
R5975 T7487 T7485 arg1Of protein,no
R5976 T7487 T7486 arg1Of protein,CK2
R5977 T7487 T7488 arg1Of protein,was
R5978 T7487 T7489 arg1Of protein,detectable
R5979 T7488 T7475 arg1Of was,Although
R5980 T7488 T7484 arg1Of was,","
R5981 T7488 T7490 arg1Of was,in
R5982 T7489 T7488 arg2Of detectable,was
R5983 T7494 T7490 arg2Of proteins,in
R5984 T7494 T7491 arg1Of proteins,our
R5985 T7494 T7492 arg1Of proteins,recombinant
R5986 T7494 T7493 arg1Of proteins,IKK
R5987 T7494 T7495 arg1Of proteins,(
R5988 T7497 T7495 arg2Of Fig.,(
R5989 T7497 T7496 arg1Of Fig.,Supplementary
R5990 T7497 T7498 arg1Of Fig.,6
R5991 T7499 T7495 arg3Of ),(
R5992 T7504 T7502 arg1Of phosphorylation,RPS3
R5993 T7504 T7503 arg1Of phosphorylation,S209
R5994 T7504 T7505 arg1Of phosphorylation,was
R5995 T7504 T7506 arg1Of phosphorylation,due
R5996 T7505 T7500 arg1Of was,Thus
R5997 T7505 T7501 arg1Of was,","
R5998 T7506 T7505 arg2Of due,was
R5999 T7506 T7507 arg1Of due,to
R6000 T7510 T7508 arg1Of specificity,the
R6001 T7510 T7509 arg1Of specificity,alternate
R6002 T7510 T7511 arg1Of specificity,of
R6003 T7510 T7516 arg1Of specificity,than
R6004 T7514 T7511 arg2Of kinase,of
R6005 T7514 T7512 arg1Of kinase,the
R6006 T7514 T7513 arg1Of kinase,IKKβ
R6007 T7516 T7507 arg2Of than,to
R6008 T7516 T7515 arg1Of than,rather
R6009 T7519 T7516 arg2Of amount,than
R6010 T7519 T7517 arg1Of amount,any
R6011 T7519 T7518 arg1Of amount,trace
R6012 T7519 T7520 arg1Of amount,of
R6013 T7519 T7522 arg2Of amount,bound
R6014 T7521 T7520 arg2Of CK2,of
R6015 T7522 T7523 arg1Of bound,to
R6016 T7524 T7523 arg2Of IKKs,to
R6017 T7526 T7525 arg1Of determine,To
R6018 T7528 T7529 arg1Of S209,is
R6019 T7529 T7526 arg2Of is,determine
R6020 T7529 T7527 arg1Of is,whether
R6021 T7532 T7529 arg2Of site,is
R6022 T7532 T7530 arg1Of site,the
R6023 T7532 T7531 arg1Of site,critical
R6024 T7532 T7533 arg2Of site,at
R6025 T7532 T7534 arg1Of site,which
R6026 T7535 T7536 arg1Of IKKβ,phosphorylates
R6027 T7536 T7533 arg1Of phosphorylates,at
R6028 T7536 T7538 arg1Of phosphorylates,in
R6029 T7537 T7536 arg2Of RPS3,phosphorylates
R6030 T7540 T7538 arg2Of cells,in
R6031 T7540 T7539 arg1Of cells,living
R6032 T7542 T7526 arg1Of we,determine
R6033 T7542 T7543 arg1Of we,transfected
R6034 T7543 T7525 modOf transfected,To
R6035 T7543 T7541 arg1Of transfected,","
R6036 T7549 T7543 arg2Of Flag-RPS3,transfected
R6037 T7549 T7544 arg1Of Flag-RPS3,the
R6038 T7549 T7545 arg1Of Flag-RPS3,wild-type
R6039 T7549 T7546 arg1Of Flag-RPS3,or
R6040 T7549 T7547 arg1Of Flag-RPS3,S209A
R6041 T7549 T7548 arg1Of Flag-RPS3,mutant
R6042 T7549 T7550 arg1Of Flag-RPS3,alone
R6043 T7549 T7553 arg1Of Flag-RPS3,together
R6044 T7549 T7556 arg1Of Flag-RPS3,into
R6045 T7550 T7552 arg1Of alone,or
R6046 T7552 T7551 arg1Of or,","
R6047 T7552 T7554 arg1Of or,with
R6048 T7553 T7552 arg2Of together,or
R6049 T7555 T7554 arg2Of IKKβ,with
R6050 T7557 T7556 arg2Of cells,into
R6051 T7560 T7561 arg1Of we,observed
R6052 T7561 T7558 arg1Of observed,Indeed
R6053 T7561 T7559 arg1Of observed,","
R6054 T7564 T7563 arg1Of IKKβ,overexpressing
R6055 T7564 T7565 arg1Of IKKβ,enhanced
R6056 T7565 T7569 arg1Of enhanced,but
R6057 T7567 T7565 arg2Of phosphorylation,enhanced
R6058 T7567 T7566 arg1Of phosphorylation,Flag-RPS3
R6059 T7569 T7561 arg2Of but,observed
R6060 T7569 T7562 arg1Of but,that
R6061 T7569 T7568 arg1Of but,","
R6062 T7570 T7571 arg1Of phosphorylation,was
R6063 T7570 T7573 arg2Of phosphorylation,eliminated
R6064 T7573 T7569 arg2Of eliminated,but
R6065 T7573 T7571 arg2Of eliminated,was
R6066 T7573 T7572 arg1Of eliminated,effectively
R6067 T7576 T7573 arg1Of substitution,eliminated
R6068 T7576 T7574 arg2Of substitution,by
R6069 T7576 T7575 arg1Of substitution,alanine
R6070 T7576 T7577 arg1Of substitution,indicating
R6071 T7579 T7580 arg1Of S209,is
R6072 T7580 T7577 arg2Of is,indicating
R6073 T7580 T7578 arg1Of is,that
R6074 T7584 T7580 arg2Of site,is
R6075 T7584 T7581 arg1Of site,the
R6076 T7584 T7582 arg1Of site,predominant
R6077 T7584 T7583 arg1Of site,target
R6078 T7584 T7585 arg1Of site,for
R6079 T7587 T7585 arg2Of phosphorylation,for
R6080 T7587 T7586 arg1Of phosphorylation,IKKβ
R6081 T7587 T7588 arg1Of phosphorylation,(
R6082 T7590 T7588 arg2Of 4d,(
R6083 T7590 T7589 arg1Of 4d,Fig.
R6084 T7591 T7588 arg3Of ),(
R6085 T7592 T7594 arg1Of We,generated
R6086 T7592 T7600 arg1Of We,confirmed
R6087 T7594 T7599 arg1Of generated,and
R6088 T7598 T7594 arg2Of antibody,generated
R6089 T7598 T7595 arg1Of antibody,a
R6090 T7598 T7596 arg1Of antibody,phospho-S209
R6091 T7598 T7597 arg1Of antibody,RPS3
R6092 T7599 T7593 arg1Of and,next
R6093 T7600 T7599 arg2Of confirmed,and
R6094 T7603 T7602 arg1Of RPS3,endogenous
R6095 T7603 T7604 arg1Of RPS3,was
R6096 T7603 T7605 arg2Of RPS3,phosphorylated
R6097 T7605 T7600 arg2Of phosphorylated,confirmed
R6098 T7605 T7601 arg1Of phosphorylated,that
R6099 T7605 T7604 arg2Of phosphorylated,was
R6100 T7605 T7606 arg1Of phosphorylated,at
R6101 T7605 T7608 arg1Of phosphorylated,in
R6102 T7605 T7612 arg1Of phosphorylated,upon
R6103 T7607 T7606 arg2Of S209,at
R6104 T7611 T7608 arg2Of manner,in
R6105 T7611 T7609 arg1Of manner,a
R6106 T7611 T7610 arg1Of manner,time-dependent
R6107 T7614 T7612 arg2Of stimulation,upon
R6108 T7614 T7613 arg1Of stimulation,TNF
R6109 T7614 T7615 arg1Of stimulation,(
R6110 T7617 T7615 arg2Of 4e,(
R6111 T7617 T7616 arg1Of 4e,Fig.
R6112 T7618 T7615 arg3Of ),(
R6113 T7624 T7621 arg1Of tail,the
R6114 T7624 T7622 arg1Of tail,RPS3
R6115 T7624 T7623 arg1Of tail,C-terminal
R6116 T7624 T7626 arg1Of tail,contains
R6117 T7626 T7619 arg1Of contains,Thus
R6118 T7626 T7620 arg1Of contains,","
R6119 T7626 T7625 arg1Of contains,potentially
R6120 T7630 T7626 arg2Of site,contains
R6121 T7630 T7627 arg1Of site,an
R6122 T7630 T7628 arg1Of site,important
R6123 T7630 T7629 arg1Of site,regulatory
R7354 T9234 T9229 arg2Of polymerase,and
R7297 T9178 T9179 arg1Of Phosphorylation,of
R7298 T9178 T9181 arg1Of Phosphorylation,and
R7299 T9180 T9179 arg2Of RPS3,of
R7300 T9184 T9181 arg2Of function,and
R7301 T9184 T9182 arg1Of function,its
R7302 T9184 T9183 arg1Of function,NF-κB
R7303 T9185 T9187 arg1Of We,examined
R7304 T9187 T9186 arg1Of examined,next
R7305 T9190 T9189 arg1Of phosphorylation,S209
R7306 T9190 T9191 arg1Of phosphorylation,plays
R7307 T9191 T9187 arg2Of plays,examined
R7308 T9191 T9188 arg1Of plays,whether
R7309 T9191 T9194 arg1Of plays,in
R7310 T9193 T9191 arg2Of role,plays
R7311 T9193 T9192 arg1Of role,a
R7312 T9197 T9194 arg2Of translocation,in
R7313 T9197 T9195 arg1Of translocation,the
R7314 T9197 T9196 arg1Of translocation,nuclear
R7315 T9197 T9198 arg1Of translocation,of
R7316 T9197 T9200 arg1Of translocation,during
R7317 T9199 T9198 arg2Of RPS3,of
R7318 T9202 T9200 arg2Of activation,during
R7319 T9202 T9201 arg1Of activation,NF-κB
R7320 T9204 T9203 arg1Of fractions,Subcellular
R7321 T9204 T9205 arg1Of fractions,from
R7322 T9204 T9213 arg1Of fractions,were
R7323 T9204 T9214 arg2Of fractions,prepared
R7324 T9204 T9216 arg2Of fractions,blotted
R7325 T9207 T9208 arg1Of wild-type,or
R7326 T9209 T9208 arg2Of S209A,or
R7327 T9212 T9205 arg2Of cells,from
R7328 T9212 T9206 arg1Of cells,either
R7329 T9212 T9207 arg1Of cells,wild-type
R7330 T9212 T9209 arg1Of cells,S209A
R7331 T9212 T9210 arg1Of cells,mutant
R7332 T9212 T9211 arg1Of cells,RPS3-transfected
R7333 T9214 T9215 arg1Of prepared,and
R7334 T9215 T9213 arg2Of and,were
R7335 T9215 T9217 arg1Of and,for
R7336 T9215 T9242 arg1Of and,","
R7337 T9215 T9243 modOf and,confirming
R7338 T9216 T9215 arg2Of blotted,and
R7339 T9219 T9218 arg1Of protein,heat-shock
R7340 T9219 T9220 arg1Of protein,90
R7341 T9219 T9221 arg1Of protein,(
R7342 T9219 T9224 arg1Of protein,","
R7343 T9219 T9229 arg1Of protein,and
R7344 T9222 T9221 arg2Of hsp90,(
R7345 T9223 T9221 arg3Of ),(
R7346 T9227 T9224 arg2Of protein,","
R7347 T9227 T9225 arg1Of protein,a
R7348 T9227 T9226 arg1Of protein,cytoplasmic
R7349 T9229 T9217 arg2Of and,for
R7350 T9229 T9228 arg1Of and,","
R7351 T9229 T9238 arg1Of and,","
R7352 T9232 T9231 arg2Of ADP-ribose,(
R7353 T9233 T9231 arg3Of ),(
R7355 T9234 T9230 arg1Of polymerase,poly
R7356 T9234 T9231 arg1Of polymerase,(
R7357 T9234 T9235 arg1Of polymerase,(
R7358 T9236 T9235 arg2Of PARP,(
R7359 T9237 T9235 arg3Of ),(
R7360 T9241 T9238 arg2Of protein,","
R7361 T9241 T9239 arg1Of protein,a
R7362 T9241 T9240 arg1Of protein,nuclear
R7363 T9246 T9243 arg2Of separation,confirming
R7364 T9246 T9244 arg1Of separation,a
R7365 T9246 T9245 arg1Of separation,clean
R7366 T9246 T9247 arg1Of separation,(
R7367 T9249 T9247 arg2Of 5a,(
R7368 T9249 T9248 arg1Of 5a,Fig.
R7369 T9250 T9247 arg3Of ),(
R7370 T9252 T9251 arg2Of expected,As
R7371 T9255 T9254 arg1Of stimulation,PMA+I
R7372 T9255 T9256 arg1Of stimulation,triggered
R7373 T9256 T9251 arg1Of triggered,As
R7374 T9256 T9253 arg1Of triggered,","
R7375 T9260 T9256 arg2Of translocation,triggered
R7376 T9260 T9257 arg1Of translocation,wild-type
R7377 T9260 T9258 arg1Of translocation,Flag-RPS3
R7378 T9260 T9259 arg1Of translocation,nuclear
R7379 T9260 T9261 arg1Of translocation,(
R7380 T9263 T9261 arg2Of 5a,(
R7381 T9263 T9262 arg1Of 5a,Fig.
R7382 T9264 T9261 arg3Of ),(
R7383 T9269 T9268 arg2Of S209A,(
R7384 T9270 T9268 arg3Of ),(
R7385 T9272 T9267 arg1Of translocation,RPS3
R7386 T9272 T9268 arg1Of translocation,(
R7387 T9272 T9271 arg1Of translocation,nuclear
R7388 T9272 T9273 arg1Of translocation,was
R7389 T9272 T9274 arg2Of translocation,attenuated
R7390 T9274 T9265 arg1Of attenuated,However
R7391 T9274 T9266 arg1Of attenuated,","
R7392 T9274 T9273 arg2Of attenuated,was
R7393 T9274 T9275 arg1Of attenuated,(
R7394 T9277 T9275 arg2Of 5a,(
R7395 T9277 T9276 arg1Of 5a,Fig.
R7396 T9278 T9275 arg3Of ),(
R7397 T9279 T9281 arg1Of We,tested
R7398 T9281 T9280 arg1Of tested,also
R7399 T9283 T9281 arg2Of impact,tested
R7400 T9283 T9282 arg1Of impact,the
R7401 T9283 T9284 arg1Of impact,of
R7402 T9285 T9284 arg2Of activating,of
R7403 T9285 T9287 arg1Of activating,by
R7404 T9286 T9285 arg2Of NF-κB,activating
R7405 T9288 T9287 arg2Of overexpressing,by
R7406 T9288 T9290 arg1Of overexpressing,on
R7407 T9289 T9288 arg2Of IKKβ,overexpressing
R7408 T9293 T9290 arg2Of translocation,on
R7409 T9293 T9291 arg1Of translocation,RPS3
R7410 T9293 T9292 arg1Of translocation,nuclear
R7411 T9295 T9294 arg1Of overexpression,IKKβ
R7412 T9295 T9296 arg1Of overexpression,activated
R7413 T9295 T9310 arg1Of overexpression,induced
R7414 T9296 T9308 arg1Of activated,and
R7415 T9297 T9296 arg2Of NF-κB,activated
R7416 T9297 T9298 arg2Of NF-κB,measured
R7417 T9298 T9299 arg1Of measured,by
R7418 T9301 T9299 arg2Of assays,by
R7419 T9301 T9300 arg1Of assays,luciferase
R7420 T9301 T9302 arg1Of assays,(
R7421 T9304 T9302 arg2Of Fig.,(
R7422 T9304 T9303 arg1Of Fig.,Supplementary
R7423 T9304 T9305 arg1Of Fig.,7
R7424 T9306 T9302 arg3Of ),(
R7425 T9308 T9307 arg1Of and,","
R7426 T9310 T9308 arg2Of induced,and
R7427 T9310 T9309 arg1Of induced,also
R7428 T9313 T9310 arg2Of translocation,induced
R7429 T9313 T9311 arg1Of translocation,the
R7430 T9313 T9312 arg1Of translocation,nuclear
R7431 T9313 T9314 arg1Of translocation,of
R7432 T9315 T9317 arg1Of wild-type,but
R7433 T9317 T9316 arg1Of but,","
R7434 T9317 T9318 arg1Of but,not
R7435 T9317 T9320 arg1Of but,","
R7436 T9319 T9317 arg2Of S209A,but
R7437 T9320 T9314 arg2Of ",",of
R7438 T9321 T9320 arg2Of RPS3,","
R7439 T9321 T9322 arg1Of RPS3,(
R7440 T9324 T9322 arg2Of 5b,(
R7441 T9324 T9323 arg1Of 5b,Fig.
R7442 T9325 T9322 arg3Of ),(
R7443 T9327 T9326 arg1Of data,These
R7444 T9327 T9328 arg1Of data,suggest
R7445 T9331 T9330 arg1Of phosphorylation,S209
R7446 T9331 T9332 arg1Of phosphorylation,is
R7447 T9331 T9333 arg1Of phosphorylation,critical
R7448 T9332 T9328 arg2Of is,suggest
R7449 T9332 T9329 arg1Of is,that
R7450 T9333 T9332 arg2Of critical,is
R7451 T9333 T9334 arg1Of critical,for
R7452 T9340 T9334 arg2Of translocation,for
R7453 T9340 T9335 arg1Of translocation,the
R7454 T9340 T9336 arg1Of translocation,NF-κB
R7455 T9340 T9337 arg1Of translocation,activation-induced
R7456 T9340 T9338 arg1Of translocation,RPS3
R7457 T9340 T9339 arg1Of translocation,nuclear
R7458 T9342 T9341 arg1Of examine,To
R7459 T9344 T9342 arg2Of role,examine
R7460 T9344 T9343 arg1Of role,the
R7461 T9344 T9345 arg1Of role,of
R7462 T9347 T9345 arg2Of phosphorylation,of
R7463 T9347 T9346 arg1Of phosphorylation,S209
R7464 T9347 T9348 arg1Of phosphorylation,of
R7465 T9349 T9348 arg2Of RPS3,of
R7466 T9349 T9350 arg1Of RPS3,to
R7467 T9353 T9350 arg2Of function6,to
R7468 T9353 T9351 arg1Of function6,its
R7469 T9353 T9352 arg1Of function6,NF-κB
R7470 T9353 T9354 arg1Of function6,","
R7471 T9353 T9356 arg1Of function6,","
R7472 T9355 T9354 arg2Of 7,","
R7473 T9357 T9356 arg2Of 30,","
R7474 T9359 T9360 arg1Of we,silenced
R7475 T9360 T9341 modOf silenced,To
R7476 T9360 T9358 arg1Of silenced,","
R7477 T9363 T9360 arg2Of expression,silenced
R7478 T9363 T9361 arg1Of expression,endogenous
R7479 T9363 T9362 arg1Of expression,RPS3
R7480 T9363 T9364 arg1Of expression,using
R7481 T9366 T9364 arg2Of siRNA,using
R7482 T9366 T9365 arg1Of siRNA,an
R7483 T9366 T9367 arg1Of siRNA,that
R7484 T9366 T9368 arg1Of siRNA,targets
R7485 T9368 T9380 arg1Of targets,","
R7486 T9368 T9381 modOf targets,followed
R7487 T9372 T9368 arg2Of region,targets
R7488 T9372 T9369 arg1Of region,the
R7489 T9372 T9370 arg1Of region,3′
R7490 T9372 T9371 arg1Of region,untranslated
R7491 T9372 T9373 arg1Of region,(
R7492 T9372 T9377 arg1Of region,of
R7493 T9375 T9373 arg2Of UTR,(
R7494 T9375 T9374 arg1Of UTR,3′
R7495 T9376 T9373 arg3Of ),(
R7496 T9379 T9377 arg2Of mRNA,of
R7497 T9379 T9378 arg1Of mRNA,RPS3
R7498 T9381 T9391 arg1Of followed,via
R7499 T9383 T9381 arg1Of complementation,followed
R7500 T9383 T9382 arg2Of complementation,by
R7501 T9383 T9384 arg1Of complementation,with
R7502 T9390 T9384 arg2Of RPS3,with
R7503 T9390 T9385 arg1Of RPS3,either
R7504 T9390 T9386 arg1Of RPS3,wild-type
R7505 T9390 T9387 arg1Of RPS3,or
R7506 T9390 T9388 arg1Of RPS3,S209A
R7507 T9390 T9389 arg1Of RPS3,mutant
R7508 T9392 T9391 arg2Of transfection,via
R7509 T9394 T9393 arg2Of expected,As
R7510 T9397 T9396 arg1Of siRNA,RPS3
R7511 T9397 T9399 arg1Of siRNA,reduced
R7512 T9397 T9409 arg1Of siRNA,did
R7513 T9397 T9411 arg1Of siRNA,affect
R7514 T9399 T9403 arg1Of reduced,compared
R7515 T9399 T9408 arg1Of reduced,but
R7516 T9402 T9399 arg2Of abundance,reduced
R7517 T9402 T9400 arg1Of abundance,endogenous
R7518 T9402 T9401 arg1Of abundance,RPS3
R7519 T9404 T9403 arg2Of to,compared
R7520 T9406 T9404 arg2Of siRNA,to
R7521 T9406 T9405 arg1Of siRNA,NS
R7522 T9408 T9393 arg1Of but,As
R7523 T9408 T9395 arg1Of but,","
R7524 T9408 T9398 arg1Of but,severely
R7525 T9408 T9407 arg1Of but,","
R7526 T9411 T9408 arg2Of affect,but
R7527 T9411 T9409 arg2Of affect,did
R7528 T9411 T9410 arg1Of affect,not
R7529 T9414 T9411 arg2Of expression,affect
R7530 T9414 T9412 arg1Of expression,the
R7531 T9414 T9413 arg1Of expression,robust
R7532 T9414 T9415 arg1Of expression,of
R7533 T9417 T9415 arg2Of RPS3,of
R7534 T9417 T9416 arg1Of RPS3,Flag-tagged
R7535 T9417 T9418 arg1Of RPS3,from
R7536 T9421 T9418 arg2Of construct,from
R7537 T9421 T9419 arg1Of construct,a
R7538 T9421 T9420 arg2Of construct,transfected
R7539 T9421 T9422 arg1Of construct,lacking
R7540 T9425 T9422 arg2Of UTR,lacking
R7541 T9425 T9423 arg1Of UTR,the
R7542 T9425 T9424 arg1Of UTR,3′
R7543 T9425 T9426 arg1Of UTR,(
R7544 T9428 T9426 arg2Of 5c,(
R7545 T9428 T9427 arg1Of 5c,Fig.
R7546 T9429 T9426 arg3Of ),(
R7547 T9430 T9432 arg1Of We,found
R7548 T9432 T9431 arg1Of found,also
R7549 T9435 T9434 arg1Of knockdown,RPS3
R7550 T9435 T9436 arg1Of knockdown,reduced
R7551 T9436 T9432 arg2Of reduced,found
R7552 T9436 T9433 arg1Of reduced,that
R7553 T9438 T9436 arg2Of expression,reduced
R7554 T9438 T9437 arg1Of expression,TNF-induced
R7555 T9438 T9439 arg1Of expression,of
R7556 T9444 T9439 arg2Of construct6,of
R7557 T9444 T9440 arg1Of construct6,an
R7558 T9444 T9441 arg1Of construct6,Ig
R7559 T9444 T9442 arg1Of construct6,κB-driven
R7560 T9444 T9443 arg1Of construct6,luciferase
R7561 T9444 T9445 arg1Of construct6,(
R7562 T9447 T9445 arg2Of 5d,(
R7563 T9447 T9446 arg1Of 5d,Fig.
R7564 T9448 T9445 arg3Of ),(
R7565 T9452 T9449 arg1Of signal,The
R7566 T9452 T9450 arg1Of signal,impaired
R7567 T9452 T9451 arg1Of signal,luciferase
R7568 T9452 T9453 arg2Of signal,caused
R7569 T9452 T9457 arg1Of signal,was
R7570 T9452 T9459 arg2Of signal,restored
R7571 T9456 T9453 arg1Of deficiency,caused
R7572 T9456 T9454 arg2Of deficiency,by
R7573 T9456 T9455 arg1Of deficiency,RPS3
R7574 T9459 T9457 arg2Of restored,was
R7575 T9459 T9458 arg1Of restored,completely
R7576 T9459 T9460 arg1Of restored,by
R7577 T9459 T9466 arg1Of restored,by
R7578 T9459 T9473 arg1Of restored,","
R7579 T9459 T9474 arg1Of restored,despite
R7580 T9460 T9464 arg1Of by,but
R7581 T9461 T9460 arg2Of transfecting,by
R7582 T9462 T9461 arg2Of wild-type,transfecting
R7583 T9464 T9463 arg1Of but,","
R7584 T9466 T9464 arg2Of by,but
R7585 T9466 T9465 arg1Of by,not
R7586 T9468 T9466 arg2Of RPS3,by
R7587 T9468 T9467 arg1Of RPS3,S209A
R7588 T9468 T9469 arg1Of RPS3,(
R7589 T9471 T9469 arg2Of 5d,(
R7590 T9471 T9470 arg1Of 5d,Fig.
R7591 T9472 T9469 arg3Of ),(
R7592 T9476 T9474 arg2Of expression,despite
R7593 T9476 T9475 arg1Of expression,equivalent
R7594 T9476 T9477 arg1Of expression,(
R7595 T9479 T9477 arg2Of 5c,(
R7596 T9479 T9478 arg1Of 5c,Fig.
R7597 T9480 T9477 arg3Of ),(
R7598 T9484 T9483 arg1Of failure,the
R7599 T9484 T9485 arg1Of failure,of
R7600 T9484 T9488 modOf failure,to
R7601 T9484 T9492 arg1Of failure,did
R7602 T9484 T9494 arg1Of failure,result
R7603 T9487 T9485 arg2Of RPS3,of
R7604 T9487 T9486 arg1Of RPS3,S209A
R7605 T9489 T9488 arg1Of restore,to
R7606 T9491 T9489 arg2Of activity,restore
R7607 T9491 T9490 arg1Of activity,luciferase
R7608 T9494 T9481 arg1Of result,Moreover
R7609 T9494 T9482 arg1Of result,","
R7610 T9494 T9492 arg2Of result,did
R7611 T9494 T9493 arg1Of result,not
R7612 T9494 T9495 arg1Of result,from
R7613 T9494 T9498 arg1Of result,because
R7614 T9497 T9495 arg2Of translation,from
R7615 T9497 T9496 arg1Of translation,defective
R7616 T9501 T9499 arg1Of overexpression,the
R7617 T9501 T9500 arg1Of overexpression,transient
R7618 T9501 T9502 arg1Of overexpression,of
R7619 T9501 T9509 arg1Of overexpression,was
R7620 T9501 T9510 arg1Of overexpression,comparable
R7621 T9505 T9502 arg2Of protein,of
R7622 T9505 T9503 arg1Of protein,green
R7623 T9505 T9504 arg1Of protein,fluorescent
R7624 T9505 T9506 arg1Of protein,(
R7625 T9507 T9506 arg2Of GFP,(
R7626 T9508 T9506 arg3Of ),(
R7627 T9509 T9498 arg2Of was,because
R7628 T9509 T9511 arg1Of was,in
R7629 T9510 T9509 arg2Of comparable,was
R7630 T9512 T9511 arg2Of cells,in
R7631 T9512 T9513 arg2Of cells,complemented
R7632 T9513 T9514 arg1Of complemented,with
R7633 T9518 T9514 arg2Of RPS3,with
R7634 T9518 T9515 arg1Of RPS3,wild-type
R7635 T9518 T9516 arg1Of RPS3,or
R7636 T9518 T9517 arg1Of RPS3,S029A
R7637 T9518 T9519 arg1Of RPS3,(
R7638 T9521 T9519 arg2Of Fig.,(
R7639 T9521 T9520 arg1Of Fig.,Supplementary
R7640 T9521 T9522 arg1Of Fig.,8
R7641 T9523 T9519 arg3Of ),(
R7642 T9524 T9525 arg1Of Taken,together
R7643 T9528 T9527 arg1Of data,these
R7644 T9528 T9529 arg1Of data,suggest
R7645 T9529 T9524 modOf suggest,Taken
R7646 T9529 T9526 arg1Of suggest,","
R7647 T9533 T9531 arg1Of phosphorylation,RPS3
R7648 T9533 T9532 arg1Of phosphorylation,S209
R7649 T9533 T9534 arg1Of phosphorylation,is
R7650 T9533 T9535 arg1Of phosphorylation,critical
R7651 T9534 T9529 arg2Of is,suggest
R7652 T9534 T9530 arg1Of is,that
R7653 T9535 T9534 arg2Of critical,is
R7654 T9535 T9536 arg1Of critical,for
R7655 T9538 T9536 arg2Of activity,for
R7656 T9538 T9537 arg1Of activity,NF-κB
R7657 T9538 T9539 arg1Of activity,involving
R7658 T9544 T9539 arg2Of site,involving
R7659 T9544 T9540 arg1Of site,the
R7660 T9544 T9541 arg1Of site,canonical
R7661 T9544 T9542 arg1Of site,Ig
R7662 T9544 T9543 arg1Of site,κB
R7663 T9545 T9547 arg1Of We,used
R7664 T9545 T9551 arg1Of We,determine
R7665 T9547 T9546 arg1Of used,next
R7666 T9549 T9547 arg2Of immunoprecipitation,used
R7667 T9549 T9548 arg1Of immunoprecipitation,chromatin
R7668 T9551 T9547 arg3Of determine,used
R7669 T9551 T9550 arg1Of determine,to
R7670 T9554 T9553 arg1Of phosphorylation,S209
R7671 T9554 T9555 arg1Of phosphorylation,affects
R7672 T9555 T9551 arg2Of affects,determine
R7673 T9555 T9552 arg1Of affects,whether
R7674 T9555 T9564 arg1Of affects,in
R7675 T9556 T9557 arg1Of RPS3,and
R7676 T9558 T9557 arg2Of p65,and
R7677 T9559 T9555 arg2Of recruitment,affects
R7678 T9559 T9556 arg1Of recruitment,RPS3
R7679 T9559 T9558 arg1Of recruitment,p65
R7680 T9559 T9560 arg1Of recruitment,to
R7681 T9563 T9560 arg2Of sites,to
R7682 T9563 T9561 arg1Of sites,specific
R7683 T9563 T9562 arg1Of sites,κB
R7684 T9566 T9564 arg2Of chromatin,in
R7685 T9566 T9565 arg1Of chromatin,intact
R7686 T9566 T9567 arg1Of chromatin,during
R7687 T9569 T9567 arg2Of activation,during
R7688 T9569 T9568 arg1Of activation,NF-κB
R7689 T9573 T9570 arg2Of cells,In
R7690 T9573 T9571 arg1Of cells,RPS3
R7691 T9573 T9572 arg1Of cells,knockdown
R7692 T9575 T9576 arg1Of PMA+I,stimulated
R7693 T9576 T9570 arg1Of stimulated,In
R7694 T9576 T9574 arg1Of stimulated,","
R7695 T9576 T9590 arg1Of stimulated,to
R7696 T9578 T9576 arg2Of recruitment,stimulated
R7697 T9578 T9577 arg1Of recruitment,the
R7698 T9578 T9579 arg1Of recruitment,of
R7699 T9581 T9580 arg1Of expressed,ectopically
R7700 T9581 T9582 arg1Of expressed,","
R7701 T9583 T9582 arg2Of Flag-tagged,","
R7702 T9584 T9581 arg1Of wild-type,expressed
R7703 T9584 T9583 arg1Of wild-type,Flag-tagged
R7704 T9584 T9586 arg1Of wild-type,but
R7705 T9586 T9579 arg2Of but,of
R7706 T9586 T9585 arg1Of but,","
R7707 T9586 T9587 arg1Of but,not
R7708 T9589 T9586 arg2Of RPS3,but
R7709 T9589 T9588 arg1Of RPS3,S209A
R7710 T9593 T9590 arg2Of sites,to
R7711 T9593 T9591 arg1Of sites,the
R7712 T9593 T9592 arg1Of sites,κB
R7713 T9593 T9594 arg1Of sites,of
R7714 T9596 T9597 arg1Of NFKBIA,and
R7715 T9598 T9597 arg2Of IL8,and
R7716 T9599 T9594 arg2Of promoters,of
R7717 T9599 T9595 arg1Of promoters,the
R7718 T9599 T9596 arg1Of promoters,NFKBIA
R7719 T9599 T9598 arg1Of promoters,IL8
R7720 T9599 T9600 arg1Of promoters,(
R7721 T9602 T9600 arg2Of 5e,(
R7722 T9602 T9601 arg1Of 5e,Fig.
R7723 T9603 T9600 arg3Of ),(
R7724 T9605 T9604 arg2Of expressing,While
R7725 T9607 T9605 arg2Of S209A,expressing
R7726 T9607 T9606 arg1Of S209A,RPS3
R7727 T9607 T9608 arg1Of S209A,had
R7728 T9608 T9605 arg3Of had,expressing
R7729 T9610 T9608 arg2Of impact,had
R7730 T9610 T9609 arg1Of impact,no
R7731 T9610 T9611 arg1Of impact,on
R7732 T9614 T9611 arg2Of translocation,on
R7733 T9614 T9612 arg1Of translocation,p65
R7734 T9614 T9613 arg1Of translocation,nuclear
R7735 T9616 T9605 arg1Of it,expressing
R7736 T9616 T9618 arg1Of it,attenuated
R7737 T9618 T9604 arg1Of attenuated,While
R7738 T9618 T9615 arg1Of attenuated,","
R7739 T9618 T9617 arg1Of attenuated,substantially
R7740 T9620 T9618 arg2Of recruitment,attenuated
R7741 T9620 T9619 arg1Of recruitment,p65
R7742 T9620 T9621 arg1Of recruitment,(
R7743 T9623 T9621 arg2Of 5e,(
R7744 T9623 T9622 arg1Of 5e,Fig.
R7745 T9624 T9621 arg3Of ),(
R7746 T9626 T9625 arg1Of experiments,Additional
R7747 T9626 T9627 arg1Of experiments,revealed
R7748 T9630 T9629 arg1Of attraction,p65
R7749 T9630 T9631 arg1Of attraction,to
R7750 T9630 T9640 arg1Of attraction,was
R7751 T9630 T9641 arg2Of attraction,increased
R7752 T9630 T9648 arg1Of attraction,consistent
R7753 T9636 T9631 arg2Of promoters,to
R7754 T9636 T9632 arg1Of promoters,RPS3-independent
R7755 T9636 T9633 arg1Of promoters,NF-κB
R7756 T9636 T9634 arg1Of promoters,target
R7757 T9636 T9635 arg1Of promoters,gene
R7758 T9636 T9638 arg1Of promoters,as
R7759 T9638 T9637 arg1Of as,such
R7760 T9639 T9638 arg2Of CD25,as
R7761 T9641 T9627 arg2Of increased,revealed
R7762 T9641 T9628 arg1Of increased,that
R7763 T9641 T9640 arg2Of increased,was
R7764 T9641 T9642 arg1Of increased,(
R7765 T9641 T9647 arg1Of increased,","
R7766 T9641 T9648 modOf increased,consistent
R7767 T9644 T9642 arg2Of Fig.,(
R7768 T9644 T9643 arg1Of Fig.,Supplementary
R7769 T9644 T9645 arg1Of Fig.,9
R7770 T9646 T9642 arg3Of ),(
R7771 T9648 T9649 arg1Of consistent,with
R7772 T9652 T9649 arg2Of observations6,with
R7773 T9652 T9650 arg1Of observations6,our
R7774 T9652 T9651 arg1Of observations6,previous
R7775 T9653 T9654 arg1Of There,was
R7776 T9657 T9656 arg1Of Flag-RPS3,significant
R7777 T9657 T9658 arg1Of Flag-RPS3,or
R7778 T9658 T9654 arg2Of or,was
R7779 T9658 T9655 arg1Of or,no
R7780 T9658 T9661 arg1Of or,to
R7781 T9660 T9658 arg2Of recruitment,or
R7782 T9660 T9659 arg1Of recruitment,p65
R7783 T9663 T9661 arg2Of promoter,to
R7784 T9663 T9662 arg1Of promoter,ACTB
R7785 T9663 T9664 arg1Of promoter,lacking
R7786 T9663 T9672 arg1Of promoter,suggesting
R7787 T9664 T9671 arg1Of lacking,","
R7788 T9664 T9672 modOf lacking,suggesting
R7789 T9666 T9664 arg2Of sites,lacking
R7790 T9666 T9665 arg1Of sites,κB
R7791 T9666 T9667 arg1Of sites,(
R7792 T9669 T9667 arg2Of 5e,(
R7793 T9669 T9668 arg1Of 5e,Fig.
R7794 T9670 T9667 arg3Of ),(
R7795 T9674 T9673 arg1Of recruitment,the
R7796 T9674 T9675 arg1Of recruitment,was
R7797 T9674 T9677 arg1Of recruitment,site-specific
R7798 T9675 T9672 arg2Of was,suggesting
R7799 T9677 T9675 arg2Of site-specific,was
R7800 T9677 T9676 arg1Of site-specific,κB
R7801 T9681 T9680 arg1Of recruitment,the
R7802 T9681 T9682 arg1Of recruitment,of
R7803 T9681 T9686 arg1Of recruitment,as
R7804 T9683 T9682 arg2Of RPS3,of
R7805 T9686 T9684 arg1Of as,as
R7806 T9686 T9685 arg1Of as,well
R7807 T9686 T9695 arg1Of as,depended
R7808 T9689 T9686 arg2Of recruitment,as
R7809 T9689 T9687 arg1Of recruitment,the
R7810 T9689 T9688 arg1Of recruitment,contingent
R7811 T9689 T9690 arg1Of recruitment,of
R7812 T9689 T9692 arg1Of recruitment,to
R7813 T9691 T9690 arg2Of p65,of
R7814 T9694 T9692 arg2Of promoters,to
R7815 T9694 T9693 arg1Of promoters,key
R7816 T9695 T9678 arg1Of depended,Thus
R7817 T9695 T9679 arg1Of depended,","
R7818 T9695 T9696 arg1Of depended,on
R7819 T9697 T9696 arg2Of S209,on
R7820 T9698 T9699 arg1Of Interleukin,8
R7821 T9698 T9700 arg1Of Interleukin,(
R7822 T9701 T9700 arg2Of IL-8,(
R7823 T9702 T9700 arg3Of ),(
R7824 T9703 T9698 arg1Of secretion,Interleukin
R7825 T9703 T9704 arg2Of secretion,induced
R7826 T9703 T9717 arg1Of secretion,was
R7827 T9703 T9718 arg2Of secretion,decreased
R7828 T9709 T9707 arg1Of receptor,T
R7829 T9709 T9708 arg1Of receptor,cell
R7830 T9709 T9710 arg1Of receptor,(
R7831 T9711 T9710 arg2Of TCR,(
R7832 T9712 T9710 arg3Of ),(
R7833 T9714 T9713 arg1Of stimulation,agonist
R7834 T9714 T9715 arg1Of stimulation,or
R7835 T9715 T9704 arg1Of or,induced
R7836 T9715 T9705 arg2Of or,by
R7837 T9715 T9706 arg1Of or,either
R7838 T9715 T9709 arg1Of or,receptor
R7839 T9716 T9715 arg2Of PMA+I,or
R7840 T9718 T9717 arg2Of decreased,was
R7841 T9718 T9719 arg1Of decreased,as
R7842 T9718 T9731 arg1Of decreased,in
R7843 T9718 T9737 arg1Of decreased,compared
R7844 T9721 T9719 arg2Of consequence,as
R7845 T9721 T9720 arg1Of consequence,a
R7846 T9721 T9722 arg1Of consequence,of
R7847 T9721 T9726 arg1Of consequence,to
R7848 T9725 T9722 arg2Of recruitment,of
R7849 T9725 T9723 arg2Of recruitment,reduced
R7850 T9725 T9724 arg1Of recruitment,RPS3/p65
R7851 T9730 T9726 arg2Of sites,to
R7852 T9730 T9727 arg1Of sites,the
R7853 T9730 T9728 arg1Of sites,IL8
R7854 T9730 T9729 arg1Of sites,κB
R7855 T9733 T9731 arg2Of presence,in
R7856 T9733 T9732 arg1Of presence,the
R7857 T9733 T9734 arg1Of presence,of
R7858 T9736 T9734 arg2Of mutant,of
R7859 T9736 T9735 arg1Of mutant,S209A
R7860 T9738 T9737 arg2Of to,compared
R7861 T9740 T9738 arg2Of RPS3,to
R7862 T9740 T9739 arg1Of RPS3,wild-type
R7863 T9740 T9741 arg1Of RPS3,(
R7864 T9743 T9741 arg2Of Fig.,(
R7865 T9743 T9742 arg1Of Fig.,Supplementary
R7866 T9743 T9744 arg1Of Fig.,10
R7867 T9745 T9741 arg3Of ),(
R7868 T9751 T9748 arg1Of expression,cell
R7869 T9751 T9749 arg1Of expression,surface
R7870 T9751 T9750 arg1Of expression,CD25
R7871 T9751 T9752 arg1Of expression,was
R7872 T9751 T9753 arg1Of expression,comparable
R7873 T9752 T9746 arg1Of was,However
R7874 T9752 T9747 arg1Of was,","
R7875 T9753 T9752 arg2Of comparable,was
R7876 T9753 T9754 arg1Of comparable,between
R7877 T9761 T9754 arg2Of cells,between
R7878 T9761 T9755 arg1Of cells,the
R7879 T9761 T9756 arg1Of cells,wild-type
R7880 T9761 T9757 arg1Of cells,and
R7881 T9761 T9758 arg1Of cells,S209A
R7882 T9761 T9759 arg1Of cells,RPS3
R7883 T9761 T9760 arg2Of cells,transfected
R7884 T9761 T9762 arg1Of cells,(
R7885 T9764 T9762 arg2Of Fig.,(
R7886 T9764 T9763 arg1Of Fig.,Supplementary
R7887 T9764 T9765 arg1Of Fig.,11
R7888 T9766 T9762 arg3Of ),(
R7889 T9771 T9769 arg1Of phosphorylation,RPS3
R7890 T9771 T9770 arg1Of phosphorylation,S209
R7891 T9771 T9772 arg1Of phosphorylation,by
R7892 T9771 T9774 arg1Of phosphorylation,is
R7893 T9771 T9776 arg2Of phosphorylation,required
R7894 T9773 T9772 arg2Of IKKβ,by
R7895 T9776 T9767 arg1Of required,Therefore
R7896 T9776 T9768 arg1Of required,","
R7897 T9776 T9774 arg2Of required,is
R7898 T9776 T9775 arg1Of required,apparently
R7899 T9776 T9777 arg1Of required,for
R7900 T9776 T9779 arg1Of required,in
R7901 T9778 T9777 arg2Of RPS3,for
R7902 T9780 T9779 arg2Of directing,in
R7903 T9780 T9782 arg1Of directing,to
R7904 T9781 T9780 arg2Of NF-κB,directing
R7905 T9785 T9782 arg2Of subset,to
R7906 T9785 T9783 arg1Of subset,a
R7907 T9785 T9784 arg1Of subset,specific
R7908 T9785 T9786 arg1Of subset,of
R7909 T9788 T9786 arg2Of genes,of
R7910 T9788 T9787 arg1Of genes,target
R9582 T11955 T11956 arg1Of NleH1,inhibits
R9583 T11956 T11960 arg1Of inhibits,vitro
R9584 T11958 T11956 arg2Of phosphorylation,inhibits
R9585 T11958 T11957 arg1Of phosphorylation,RPS3
R9586 T11960 T11959 arg1Of vitro,in
R9587 T11962 T11961 arg1Of pathogens,EHEC
R9588 T11962 T11963 arg1Of pathogens,are
R9589 T11966 T11963 arg2Of agents,are
R9590 T11966 T11964 arg1Of agents,important
R9591 T11966 T11965 arg1Of agents,causative
R9592 T11966 T11967 arg1Of agents,of
R9593 T11970 T11969 arg1Of disease,foodborne
R9594 T11970 T11971 arg1Of disease,and
R9595 T11971 T11967 arg2Of and,of
R9596 T11971 T11968 arg1Of and,both
R9597 T11974 T11971 arg2Of failure31,and
R9598 T11974 T11972 arg1Of failure31,pediatric
R9599 T11974 T11973 arg1Of failure31,renal
R9600 T11975 T11976 arg1Of EHEC,utilize
R9601 T11977 T11976 arg2Of T3SS,utilize
R9602 T11977 T11978 modOf T3SS,to
R9603 T11979 T11978 arg1Of inject,to
R9604 T11979 T11982 arg1Of inject,directly
R9605 T11979 T11983 arg1Of inject,into
R9606 T11981 T11979 arg2Of proteins,inject
R9607 T11981 T11980 arg1Of proteins,effector
R9608 T11986 T11983 arg2Of cells32,into
R9609 T11986 T11984 arg1Of cells32,intestinal
R9610 T11986 T11985 arg1Of cells32,epithelial
R9611 T11986 T11990 arg2Of cells32,of
R9612 T11986 T11991 arg1Of cells32,which
R9613 T11989 T11988 arg1Of subset,a
R9614 T11989 T11990 arg1Of subset,of
R9615 T11989 T11992 arg1Of subset,inhibit
R9616 T11992 T11987 arg1Of inhibit,","
R9617 T11995 T11992 arg2Of responses9,inhibit
R9618 T11995 T11993 arg1Of responses9,NF-κB-dependent
R9619 T11995 T11994 arg1Of responses9,innate
R9620 T11995 T11996 arg1Of responses9,","
R9621 T11997 T11996 arg2Of 33-38,","
R9622 T12001 T12002 arg1Of O157,:
R9623 T12002 T11999 arg1Of :,E.
R9624 T12002 T12000 arg1Of :,coli
R9625 T12003 T12002 arg2Of H7,:
R9626 T12007 T11998 arg1Of NleH1,The
R9627 T12007 T12001 arg1Of NleH1,O157
R9628 T12007 T12003 arg1Of NleH1,H7
R9629 T12007 T12004 arg1Of NleH1,EDL933
R9630 T12007 T12005 arg1Of NleH1,effector
R9631 T12007 T12006 arg1Of NleH1,protein
R9632 T12007 T12008 arg1Of NleH1,binds
R9633 T12007 T12011 arg1Of NleH1,attenuates
R9634 T12007 T12017 arg1Of NleH1,impairing
R9635 T12008 T12009 arg1Of binds,to
R9636 T12008 T12010 arg1Of binds,and
R9637 T12010 T12015 arg1Of and,","
R9638 T12010 T12017 modOf and,impairing
R9639 T12011 T12010 arg2Of attenuates,and
R9640 T12014 T12011 arg2Of translocation,attenuates
R9641 T12014 T12012 arg1Of translocation,RPS3
R9642 T12014 T12013 arg1Of translocation,nuclear
R9643 T12017 T12016 arg1Of impairing,thus
R9644 T12020 T12017 arg2Of signaling9,impairing
R9645 T12020 T12018 arg1Of signaling9,RPS3-dependent
R9646 T12020 T12019 arg1Of signaling9,NF-κB
R9647 T12021 T12023 arg1Of We,hypothesized
R9648 T12023 T12022 arg1Of hypothesized,therefore
R9649 T12025 T12026 arg1Of NleH1,may
R9650 T12025 T12027 arg1Of NleH1,function
R9651 T12025 T12029 arg1Of NleH1,inhibiting
R9652 T12027 T12023 arg2Of function,hypothesized
R9653 T12027 T12024 arg1Of function,that
R9654 T12027 T12026 arg2Of function,may
R9655 T12027 T12028 arg1Of function,by
R9656 T12029 T12028 arg2Of inhibiting,by
R9657 T12032 T12029 arg2Of phosphorylation,inhibiting
R9658 T12032 T12030 arg1Of phosphorylation,RPS3
R9659 T12032 T12031 arg1Of phosphorylation,S209
R9660 T12034 T12033 arg2Of expected,As
R9661 T12038 T12036 arg1Of amounts,transfecting
R9662 T12038 T12037 arg1Of amounts,increasing
R9663 T12038 T12039 arg1Of amounts,of
R9664 T12038 T12042 arg1Of amounts,blocked
R9665 T12041 T12039 arg2Of plasmid,of
R9666 T12041 T12040 arg1Of plasmid,NleH1-HA
R9667 T12042 T12033 arg1Of blocked,As
R9668 T12042 T12035 arg1Of blocked,","
R9669 T12042 T12046 arg1Of blocked,in
R9670 T12045 T12042 arg2Of activation,blocked
R9671 T12045 T12043 arg1Of activation,TNFα-induced
R9672 T12045 T12044 arg1Of activation,NF-κB
R9673 T12051 T12050 arg2Of Fig.,(
R9674 T12051 T12052 arg1Of Fig.,6a-b
R9675 T12053 T12050 arg3Of ),(
R9676 T12054 T12046 arg2Of 9,in
R9677 T12054 T12047 arg1Of 9,a
R9678 T12054 T12048 arg1Of 9,dose-dependent
R9679 T12054 T12049 arg1Of 9,manner
R9680 T12054 T12050 arg1Of 9,(
R9681 T12057 T12058 arg1Of NleH1,reduced
R9682 T12058 T12055 arg1Of reduced,Remarkably
R9683 T12058 T12056 arg1Of reduced,","
R9684 T12058 T12068 arg1Of reduced,to
R9685 T12060 T12064 arg1Of TNF-induced,as
R9686 T12064 T12059 arg1Of as,both
R9687 T12064 T12061 arg1Of as,","
R9688 T12064 T12062 arg1Of as,as
R9689 T12064 T12063 arg1Of as,well
R9690 T12065 T12064 arg2Of basal,as
R9691 T12067 T12058 arg2Of phosphorylation,reduced
R9692 T12067 T12060 arg1Of phosphorylation,TNF-induced
R9693 T12067 T12065 arg1Of phosphorylation,basal
R9694 T12067 T12066 arg1Of phosphorylation,RPS3
R9695 T12070 T12069 arg1Of 20,roughly
R9696 T12071 T12068 arg2Of %,to
R9697 T12071 T12070 arg1Of %,20
R9698 T12071 T12072 arg1Of %,of
R9699 T12074 T12072 arg2Of control,of
R9700 T12074 T12073 arg1Of control,vehicle
R9701 T12074 T12075 arg1Of control,(
R9702 T12077 T12075 arg2Of 6c,(
R9703 T12077 T12076 arg1Of 6c,Fig.
R9704 T12078 T12075 arg3Of ),(
R9705 T12080 T12079 arg1Of NleH1,Expressing
R9706 T12080 T12081 arg1Of NleH1,does
R9707 T12080 T12083 arg1Of NleH1,interfere
R9708 T12083 T12081 arg2Of interfere,does
R9709 T12083 T12082 arg1Of interfere,not
R9710 T12083 T12084 arg1Of interfere,with
R9711 T12083 T12092 arg1Of interfere,","
R9712 T12083 T12093 arg1Of interfere,consistent
R9713 T12088 T12086 arg1Of activation,TNF-induced
R9714 T12088 T12087 arg1Of activation,IKK
R9715 T12088 T12089 arg1Of activation,or
R9716 T12089 T12084 arg2Of or,with
R9717 T12089 T12085 arg1Of or,either
R9718 T12091 T12089 arg2Of degradation,or
R9719 T12091 T12090 arg1Of degradation,IκBα
R9720 T12093 T12094 arg1Of consistent,with
R9721 T12096 T12094 arg2Of lack,with
R9722 T12096 T12095 arg1Of lack,the
R9723 T12096 T12097 arg1Of lack,of
R9724 T12096 T12100 arg1Of lack,on
R9725 T12099 T12097 arg2Of impact,of
R9726 T12099 T12098 arg1Of impact,NleH1
R9727 T12103 T12100 arg2Of translocation9,on
R9728 T12103 T12101 arg1Of translocation9,p65
R9729 T12103 T12102 arg1Of translocation9,nuclear
R9730 T12103 T12104 arg1Of translocation9,(
R9731 T12106 T12104 arg2Of 6c,(
R9732 T12106 T12105 arg1Of 6c,Fig.
R9733 T12107 T12104 arg3Of ),(
R9734 T12109 T12108 arg1Of determine,To
R9735 T12111 T12112 arg1Of NleH1,inhibits
R9736 T12112 T12109 arg2Of inhibits,determine
R9737 T12112 T12110 arg1Of inhibits,if
R9738 T12114 T12112 arg2Of phosphorylation,inhibits
R9739 T12114 T12113 arg1Of phosphorylation,RPS3
R9740 T12116 T12109 arg1Of we,determine
R9741 T12116 T12117 arg1Of we,infected
R9742 T12117 T12108 modOf infected,To
R9743 T12117 T12115 arg1Of infected,","
R9744 T12117 T12120 arg1Of infected,with
R9745 T12117 T12136 arg1Of infected,with
R9746 T12119 T12117 arg2Of cells,infected
R9747 T12119 T12118 arg1Of cells,HeLa
R9748 T12120 T12135 arg1Of with,or
R9749 T12123 T12121 arg1Of O157,E.
R9750 T12123 T12122 arg1Of O157,coli
R9751 T12123 T12124 arg1Of O157,:
R9752 T12124 T12120 arg2Of :,with
R9753 T12126 T12124 arg2Of strains,:
R9754 T12126 T12125 arg1Of strains,H7
R9755 T12126 T12127 arg1Of strains,possessing
R9756 T12126 T12129 arg1Of strains,lacking
R9757 T12127 T12128 arg1Of possessing,or
R9758 T12129 T12128 arg2Of lacking,or
R9759 T12131 T12127 arg2Of nleH1,possessing
R9760 T12131 T12129 arg2Of nleH1,lacking
R9761 T12131 T12130 arg1Of nleH1,either
R9762 T12131 T12132 arg1Of nleH1,(
R9763 T12133 T12132 arg2Of ΔnleH1,(
R9764 T12134 T12132 arg3Of ),(
R9765 T12136 T12135 arg2Of with,or
R9766 T12138 T12136 arg2Of strain,with
R9767 T12138 T12137 arg1Of strain,a
R9768 T12138 T12139 arg1Of strain,lacking
R9769 T12142 T12139 arg2Of T3SS,lacking
R9770 T12142 T12140 arg1Of T3SS,a
R9771 T12142 T12141 arg1Of T3SS,functional
R9772 T12142 T12143 arg1Of T3SS,unable
R9773 T12145 T12143 arg2Of inject,unable
R9774 T12145 T12144 arg1Of inject,to
R9775 T12146 T12145 arg2Of NleH1,inject
R9776 T12146 T12147 arg1Of NleH1,into
R9777 T12149 T12147 arg2Of cells,into
R9778 T12149 T12148 arg1Of cells,mammalian
R9779 T12149 T12150 arg1Of cells,(
R9780 T12151 T12150 arg2Of ΔescN,(
R9781 T12152 T12150 arg3Of ),(
R9782 T12155 T12153 arg2Of cells,In
R9783 T12155 T12154 arg1Of cells,uninfected
R9784 T12157 T12158 arg1Of TNF-treatment,stimulated
R9785 T12157 T12167 arg1Of TNF-treatment,peaking
R9786 T12158 T12153 arg1Of stimulated,In
R9787 T12158 T12156 arg1Of stimulated,","
R9788 T12158 T12166 arg1Of stimulated,","
R9789 T12158 T12167 modOf stimulated,peaking
R9790 T12161 T12158 arg2Of increase,stimulated
R9791 T12161 T12159 arg1Of increase,a
R9792 T12161 T12160 arg1Of increase,∼7-fold
R9793 T12161 T12162 arg1Of increase,in
R9794 T12165 T12162 arg2Of phosphorylation,in
R9795 T12165 T12163 arg1Of phosphorylation,RPS3
R9796 T12165 T12164 arg1Of phosphorylation,S209
R9797 T12167 T12168 arg1Of peaking,at
R9798 T12167 T12171 arg1Of peaking,(
R9799 T12170 T12168 arg2Of minutes,at
R9800 T12170 T12169 arg1Of minutes,30
R9801 T12172 T12171 arg2Of Fig.,(
R9802 T12172 T12173 arg1Of Fig.,6d
R9803 T12174 T12171 arg3Of ),(
R9804 T12176 T12175 arg2Of contrast,By
R9805 T12180 T12178 arg1Of phosphorylation,RPS3
R9806 T12180 T12179 arg1Of phosphorylation,S209
R9807 T12180 T12181 arg1Of phosphorylation,was
R9808 T12180 T12183 arg1Of phosphorylation,impaired
R9809 T12181 T12175 arg1Of was,By
R9810 T12181 T12177 arg1Of was,","
R9811 T12181 T12184 arg1Of was,in
R9812 T12181 T12194 arg1Of was,(
R9813 T12183 T12181 arg2Of impaired,was
R9814 T12183 T12182 arg1Of impaired,substantially
R9815 T12185 T12184 arg2Of cells,in
R9816 T12185 T12186 arg2Of cells,infected
R9817 T12185 T12192 arg1Of cells,:
R9818 T12186 T12187 arg1Of infected,with
R9819 T12191 T12187 arg2Of O157,with
R9820 T12191 T12188 arg1Of O157,wild-type
R9821 T12191 T12189 arg1Of O157,E.
R9822 T12191 T12190 arg1Of O157,coli
R9823 T12193 T12192 arg2Of H7,:
R9824 T12195 T12194 arg2Of Fig.,(
R9825 T12195 T12196 arg1Of Fig.,6d
R9826 T12197 T12194 arg3Of ),(
R9827 T12203 T12200 arg1Of phosphorylation,TNF-induced
R9828 T12203 T12201 arg1Of phosphorylation,RPS3
R9829 T12203 T12202 arg1Of phosphorylation,S209
R9830 T12203 T12204 arg1Of phosphorylation,was
R9831 T12203 T12205 arg1Of phosphorylation,unimpaired
R9832 T12204 T12198 arg1Of was,However
R9833 T12204 T12199 arg1Of was,","
R9834 T12204 T12206 arg1Of was,in
R9835 T12205 T12204 arg2Of unimpaired,was
R9836 T12207 T12206 arg2Of cells,in
R9837 T12207 T12208 arg2Of cells,infected
R9838 T12208 T12209 arg1Of infected,with
R9839 T12208 T12214 arg1Of infected,(
R9840 T12211 T12212 arg1Of ΔnleH1,or
R9841 T12212 T12209 arg2Of or,with
R9842 T12212 T12210 arg1Of or,either
R9843 T12213 T12212 arg2Of ΔescN,or
R9844 T12215 T12214 arg2Of Fig.,(
R9845 T12215 T12216 arg1Of Fig.,6d
R9846 T12217 T12214 arg3Of ),(
R9847 T12218 T12219 arg1Of We,showed
R9848 T12219 T12220 arg1Of showed,previously
R9849 T12222 T12224 arg1Of wild-type,but
R9850 T12224 T12223 arg1Of but,","
R9851 T12224 T12225 arg1Of but,not
R9852 T12224 T12227 arg1Of but,or
R9853 T12226 T12224 arg2Of ΔnleH1,but
R9854 T12227 T12232 arg1Of or,:
R9855 T12231 T12227 arg2Of O157,or
R9856 T12231 T12228 arg1Of O157,ΔescN
R9857 T12231 T12229 arg1Of O157,E.
R9858 T12231 T12230 arg1Of O157,coli
R9859 T12232 T12235 arg1Of :,attenuated
R9860 T12233 T12232 arg2Of H7,:
R9861 T12235 T12219 arg2Of attenuated,showed
R9862 T12235 T12221 arg1Of attenuated,that
R9863 T12235 T12234 arg1Of attenuated,significantly
R9864 T12239 T12235 arg2Of translocation9,attenuated
R9865 T12239 T12236 arg1Of translocation9,TNF-induced
R9866 T12239 T12237 arg1Of translocation9,RPS3
R9867 T12239 T12238 arg1Of translocation9,nuclear
R9868 T12241 T12240 arg1Of parallel,The
R9869 T12241 T12242 arg1Of parallel,between
R9870 T12241 T12249 arg1Of parallel,during
R9871 T12241 T12253 arg1Of parallel,provides
R9872 T12244 T12243 arg1Of phosphorylation,RPS3
R9873 T12244 T12245 arg1Of phosphorylation,and
R9874 T12245 T12242 arg2Of and,between
R9875 T12248 T12245 arg2Of translocation,and
R9876 T12248 T12246 arg1Of translocation,its
R9877 T12248 T12247 arg1Of translocation,nuclear
R9878 T12252 T12249 arg2Of infection,during
R9879 T12252 T12250 arg1Of infection,E.
R9880 T12252 T12251 arg1Of infection,coli
R9881 T12254 T12253 arg2Of evidence,provides
R9882 T12254 T12255 arg1Of evidence,in
R9883 T12257 T12255 arg2Of context,in
R9884 T12257 T12256 arg1Of context,the
R9885 T12257 T12258 arg1Of context,of
R9886 T12262 T12258 arg2Of process,of
R9887 T12262 T12259 arg1Of process,an
R9888 T12262 T12260 arg1Of process,NF-κB-dependent
R9889 T12262 T12261 arg1Of process,disease
R9890 T12266 T12263 arg1Of phosphorylation,that
R9891 T12266 T12264 arg1Of phosphorylation,RPS3
R9892 T12266 T12265 arg1Of phosphorylation,S209
R9893 T12266 T12267 arg1Of phosphorylation,is
R9894 T12266 T12268 arg1Of phosphorylation,important
R9895 T12267 T12253 arg3Of is,provides
R9896 T12268 T12267 arg2Of important,is
R9897 T12268 T12269 arg1Of important,for
R9898 T12271 T12269 arg2Of translocation,for
R9899 T12271 T12270 arg1Of translocation,nuclear
R9900 T12273 T12272 arg1Of discovery,Our
R9901 T12273 T12280 arg1Of discovery,suggested
R9902 T12275 T12276 arg1Of NleH1,inhibits
R9903 T12276 T12273 arg2Of inhibits,discovery
R9904 T12276 T12274 arg1Of inhibits,that
R9905 T12279 T12276 arg2Of phosphorylation,inhibits
R9906 T12279 T12277 arg1Of phosphorylation,RPS3
R9907 T12279 T12278 arg1Of phosphorylation,S209
R9908 T12282 T12283 arg1Of it,should
R9909 T12282 T12285 arg1Of it,blocks
R9910 T12285 T12280 arg2Of blocks,suggested
R9911 T12285 T12281 arg1Of blocks,that
R9912 T12285 T12283 arg2Of blocks,should
R9913 T12285 T12284 arg1Of blocks,also
R9914 T12290 T12285 arg2Of transcription,blocks
R9915 T12290 T12286 arg1Of transcription,RPS3-dependent
R9916 T12290 T12287 arg1Of transcription,NF-κB
R9917 T12290 T12288 arg1Of transcription,target
R9918 T12290 T12289 arg1Of transcription,gene
R9919 T12290 T12291 arg1Of transcription,(
R9920 T12293 T12294 arg1Of IL8,","
R9921 T12294 T12297 arg1Of ",",and
R9922 T12295 T12294 arg2Of NFKBIA,","
R9923 T12297 T12291 arg2Of and,(
R9924 T12297 T12292 arg1Of and,e.g.
R9925 T12297 T12296 arg1Of and,","
R9926 T12298 T12297 arg2Of TNFAIP3,and
R9927 T12299 T12291 arg3Of ),(
R9928 T12303 T12302 arg1Of genes,these
R9929 T12303 T12304 arg1Of genes,were
R9930 T12303 T12307 arg2Of genes,upregulated
R9931 T12303 T12321 arg2Of genes,induced
R9932 T12306 T12305 arg1Of modestly,only
R9933 T12307 T12308 arg1Of upregulated,in
R9934 T12307 T12316 arg1Of upregulated,:
R9935 T12307 T12319 arg1Of upregulated,but
R9936 T12309 T12308 arg2Of cells,in
R9937 T12309 T12310 arg2Of cells,infected
R9938 T12310 T12311 arg1Of infected,with
R9939 T12315 T12311 arg2Of O157,with
R9940 T12315 T12312 arg1Of O157,wild-type
R9941 T12315 T12313 arg1Of O157,E.
R9942 T12315 T12314 arg1Of O157,coli
R9943 T12317 T12307 arg3Of H7,upregulated
R9944 T12319 T12300 arg1Of but,Indeed
R9945 T12319 T12301 arg1Of but,","
R9946 T12319 T12304 arg2Of but,were
R9947 T12319 T12306 arg1Of but,modestly
R9948 T12319 T12318 arg1Of but,","
R9949 T12321 T12319 arg2Of induced,but
R9950 T12321 T12320 arg1Of induced,significantly
R9951 T12321 T12322 arg1Of induced,in
R9952 T12323 T12322 arg2Of cells,in
R9953 T12323 T12324 arg2Of cells,infected
R9954 T12324 T12325 arg1Of infected,with
R9955 T12327 T12328 arg1Of ΔnleH1,or
R9956 T12329 T12328 arg2Of ΔescN,or
R9957 T12330 T12325 arg2Of strains,with
R9958 T12330 T12326 arg1Of strains,either
R9959 T12330 T12327 arg1Of strains,ΔnleH1
R9960 T12330 T12329 arg1Of strains,ΔescN
R9961 T12330 T12331 arg1Of strains,(
R9962 T12333 T12331 arg2Of 6e,(
R9963 T12333 T12332 arg1Of 6e,Fig.
R9964 T12334 T12331 arg3Of ),(
R9965 T12336 T12335 arg2Of contrast,In
R9966 T12338 T12340 arg1Of deleting,had
R9967 T12339 T12338 arg2Of nleH1,deleting
R9968 T12340 T12335 arg1Of had,In
R9969 T12340 T12337 arg1Of had,","
R9970 T12340 T12343 arg1Of had,on
R9971 T12342 T12340 arg2Of impact,had
R9972 T12342 T12341 arg1Of impact,no
R9973 T12345 T12343 arg2Of expression,on
R9974 T12345 T12344 arg1Of expression,the
R9975 T12345 T12346 arg1Of expression,of
R9976 T12348 T12346 arg2Of genes,of
R9977 T12348 T12347 arg1Of genes,RPS3-independent
R9978 T12348 T12349 arg1Of genes,","
R9979 T12348 T12350 arg1Of genes,including
R9980 T12351 T12352 arg1Of CD25,and
R9981 T12352 T12350 arg2Of and,including
R9982 T12352 T12354 arg1Of and,(
R9983 T12353 T12352 arg2Of TNFSF13B,and
R9984 T12356 T12354 arg2Of Fig.,(
R9985 T12356 T12355 arg1Of Fig.,Supplementary
R9986 T12356 T12357 arg1Of Fig.,12
R9987 T12358 T12354 arg3Of ),(
R9988 T12361 T12360 arg1Of results,these
R9989 T12361 T12362 arg1Of results,demonstrate
R9990 T12362 T12359 arg1Of demonstrate,Together
R9991 T12364 T12366 arg1Of NleH1,inhibits
R9992 T12366 T12362 arg2Of inhibits,demonstrate
R9993 T12366 T12363 arg1Of inhibits,that
R9994 T12366 T12365 arg1Of inhibits,specifically
R9995 T12366 T12371 arg1Of inhibits,by
R9996 T12370 T12366 arg2Of response,inhibits
R9997 T12370 T12367 arg1Of response,the
R9998 T12370 T12368 arg1Of response,protective
R9999 T12370 T12369 arg1Of response,immune
R10000 T12373 T12372 arg1Of blocking,directly
R10001 T12373 T12377 arg1Of blocking,and
R10002 T12376 T12373 arg2Of phosphorylation,blocking
R10003 T12376 T12374 arg1Of phosphorylation,RPS3
R10004 T12376 T12375 arg1Of phosphorylation,S209
R10005 T12377 T12371 arg2Of and,by
R10006 T12379 T12377 arg2Of impairing,and
R10007 T12379 T12378 arg1Of impairing,thereby
R10008 T12384 T12379 arg2Of genes,impairing
R10009 T12384 T12380 arg1Of genes,critical
R10010 T12384 T12381 arg1Of genes,RPS3-dependent
R10011 T12384 T12382 arg1Of genes,NF-κB
R10012 T12384 T12383 arg1Of genes,target
R11032 T13762 T13763 arg1Of NleH1,inhibits
R11033 T13763 T13768 arg1Of inhibits,vivo
R11034 T13766 T13763 arg2Of phosphorylation,inhibits
R11035 T13766 T13764 arg1Of phosphorylation,RPS3
R11036 T13766 T13765 arg1Of phosphorylation,S209
R11037 T13768 T13767 arg1Of vivo,in
R11038 T13769 T13771 arg1Of We,utilized
R11039 T13769 T13778 arg1Of We,determine
R11040 T13771 T13770 arg1Of utilized,previously
R11041 T13771 T13777 modOf utilized,to
R11042 T13776 T13771 arg2Of model,utilized
R11043 T13776 T13772 arg1Of model,a
R11044 T13776 T13773 arg1Of model,gnotobiotic
R11045 T13776 T13774 arg1Of model,piglet
R11046 T13776 T13775 arg1Of model,infection
R11047 T13778 T13777 arg1Of determine,to
R11048 T13780 T13781 arg2Of piglets,infected
R11049 T13780 T13785 arg1Of piglets,died
R11050 T13781 T13782 arg1Of infected,with
R11051 T13784 T13782 arg2Of mutant,with
R11052 T13784 T13783 arg1Of mutant,ΔnleH1
R11053 T13785 T13778 arg2Of died,determine
R11054 T13785 T13779 arg1Of died,that
R11055 T13785 T13787 arg1Of died,rapidly
R11056 T13785 T13796 arg1Of died,:
R11057 T13787 T13786 arg1Of rapidly,more
R11058 T13787 T13788 arg1Of rapidly,than
R11059 T13789 T13788 arg2Of those,than
R11060 T13789 T13790 arg2Of those,infected
R11061 T13790 T13791 arg1Of infected,with
R11062 T13795 T13791 arg2Of O157,with
R11063 T13795 T13792 arg1Of O157,wild-type
R11064 T13795 T13793 arg1Of O157,E.
R11065 T13795 T13794 arg1Of O157,coli
R11066 T13797 T13785 arg2Of H7,died
R11067 T13798 T13799 arg2Of Piglets,infected
R11068 T13798 T13802 arg1Of Piglets,displayed
R11069 T13799 T13800 arg1Of infected,with
R11070 T13801 T13800 arg2Of ΔnleH1,with
R11071 T13804 T13802 arg2Of disease,displayed
R11072 T13804 T13803 arg1Of disease,clinical
R11073 T13804 T13805 arg1Of disease,consistent
R11074 T13805 T13806 arg1Of consistent,with
R11075 T13805 T13813 arg1Of consistent,with
R11076 T13806 T13812 arg1Of with,but
R11077 T13810 T13806 arg2Of response,with
R11078 T13810 T13807 arg1Of response,a
R11079 T13810 T13808 arg1Of response,robust
R11080 T13810 T13809 arg1Of response,inflammatory
R11081 T13812 T13811 arg1Of but,","
R11082 T13813 T13812 arg2Of with,but
R11083 T13816 T13814 arg2Of colonization,reduced
R11084 T13816 T13815 arg1Of colonization,bacterial
R11085 T13816 T13817 arg1Of colonization,and
R11086 T13817 T13813 arg2Of and,with
R11087 T13819 T13817 arg2Of diarrhea9,and
R11088 T13819 T13818 arg1Of diarrhea9,little
R11089 T13822 T13820 arg2Of paradoxical,While
R11090 T13822 T13821 arg1Of paradoxical,seemingly
R11091 T13822 T13823 arg1Of paradoxical,","
R11092 T13822 T13824 arg1Of paradoxical,based
R11093 T13825 T13824 arg2Of on,based
R11094 T13829 T13825 arg2Of data,on
R11095 T13829 T13826 arg1Of data,our
R11096 T13829 T13827 arg1Of data,cell
R11097 T13829 T13828 arg1Of data,culture
R11098 T13829 T13830 arg1Of data,(
R11099 T13832 T13830 arg2Of 6d,(
R11100 T13832 T13831 arg1Of 6d,Fig.
R11101 T13833 T13830 arg3Of ),(
R11102 T13835 T13836 arg1Of we,hypothesized
R11103 T13836 T13820 arg1Of hypothesized,While
R11104 T13836 T13834 arg1Of hypothesized,","
R11105 T13838 T13839 arg1Of NleH1,blocked
R11106 T13839 T13836 arg2Of blocked,hypothesized
R11107 T13839 T13837 arg1Of blocked,that
R11108 T13839 T13844 arg1Of blocked,vivo
R11109 T13839 T13845 arg1Of blocked,","
R11110 T13839 T13847 modOf blocked,preventing
R11111 T13842 T13839 arg2Of phosphorylation,blocked
R11112 T13842 T13840 arg1Of phosphorylation,RPS3
R11113 T13842 T13841 arg1Of phosphorylation,S209
R11114 T13844 T13843 arg1Of vivo,in
R11115 T13847 T13846 arg1Of preventing,thereby
R11116 T13850 T13847 arg2Of translocation,preventing
R11117 T13850 T13848 arg1Of translocation,RPS3
R11118 T13850 T13849 arg1Of translocation,nuclear
R11119 T13850 T13851 arg1Of translocation,in
R11120 T13853 T13851 arg2Of piglets,in
R11121 T13853 T13852 arg1Of piglets,infected
R11122 T13854 T13855 arg1Of We,isolated
R11123 T13854 T13862 arg1Of We,subjected
R11124 T13854 T13866 arg1Of We,using
R11125 T13855 T13858 arg1Of isolated,at
R11126 T13855 T13861 arg1Of isolated,and
R11127 T13857 T13855 arg2Of colons,isolated
R11128 T13857 T13856 arg1Of colons,piglet
R11129 T13859 T13858 arg2Of necropsy,at
R11130 T13861 T13860 arg1Of and,","
R11131 T13862 T13861 arg2Of subjected,and
R11132 T13862 T13864 arg1Of subjected,to
R11133 T13862 T13866 modOf subjected,using
R11134 T13863 T13862 arg2Of them,subjected
R11135 T13865 T13864 arg2Of immunohistochemistry,to
R11136 T13869 T13866 arg2Of antibody,using
R11137 T13869 T13867 arg1Of antibody,our
R11138 T13869 T13868 arg1Of antibody,phospho-RPS3
R11139 T13870 T13871 arg1Of Consistent,with
R11140 T13873 T13872 arg1Of vitro,in
R11141 T13874 T13871 arg2Of data,with
R11142 T13874 T13873 arg1Of data,vitro
R11143 T13876 T13870 arg1Of piglets,Consistent
R11144 T13876 T13877 arg2Of piglets,infected
R11145 T13876 T13885 arg1Of piglets,exhibited
R11146 T13877 T13878 arg1Of infected,with
R11147 T13882 T13879 arg1Of O157,wild-type
R11148 T13882 T13880 arg1Of O157,E.
R11149 T13882 T13881 arg1Of O157,coli
R11150 T13882 T13883 arg1Of O157,:
R11151 T13883 T13878 arg2Of :,with
R11152 T13884 T13883 arg2Of H7,:
R11153 T13885 T13870 modOf exhibited,Consistent
R11154 T13885 T13875 arg1Of exhibited,","
R11155 T13885 T13892 arg1Of exhibited,","
R11156 T13885 T13893 arg1Of exhibited,whereas
R11157 T13886 T13887 arg1Of diffuse,and
R11158 T13888 T13887 arg2Of low,and
R11159 T13891 T13885 arg2Of staining,exhibited
R11160 T13891 T13886 arg1Of staining,diffuse
R11161 T13891 T13888 arg1Of staining,low
R11162 T13891 T13889 arg1Of staining,intensity
R11163 T13891 T13890 arg1Of staining,phospho-RPS3
R11164 T13895 T13894 arg2Of piglets,in
R11165 T13895 T13896 arg2Of piglets,infected
R11166 T13896 T13897 arg1Of infected,with
R11167 T13899 T13897 arg2Of mutant,with
R11168 T13899 T13898 arg1Of mutant,ΔnleH1
R11169 T13902 T13901 arg1Of expression,phospho-RPS3
R11170 T13902 T13903 arg1Of expression,was
R11171 T13902 T13904 arg1Of expression,florid
R11172 T13902 T13906 arg1Of expression,intense
R11173 T13903 T13893 arg2Of was,whereas
R11174 T13903 T13894 arg1Of was,in
R11175 T13903 T13900 arg1Of was,","
R11176 T13903 T13907 arg1Of was,(
R11177 T13904 T13905 arg1Of florid,and
R11178 T13905 T13903 arg2Of and,was
R11179 T13906 T13905 arg2Of intense,and
R11180 T13908 T13907 arg2Of Fig.,(
R11181 T13908 T13909 arg1Of Fig.,6f
R11182 T13910 T13907 arg3Of ),(
R11183 T13912 T13911 arg1Of data,These
R11184 T13912 T13913 arg1Of data,demonstrate
R11185 T13915 T13916 arg1Of NleH1,inhibits
R11186 T13916 T13913 arg2Of inhibits,demonstrate
R11187 T13916 T13914 arg1Of inhibits,that
R11188 T13916 T13922 arg1Of inhibits,vitro
R11189 T13916 T13925 arg1Of inhibits,vivo
R11190 T13916 T13926 arg1Of inhibits,","
R11191 T13916 T13927 arg1Of inhibits,which
R11192 T13916 T13928 arg1Of inhibits,might
R11193 T13916 T13929 arg1Of inhibits,benefit
R11194 T13919 T13916 arg2Of phosphorylation,inhibits
R11195 T13919 T13917 arg1Of phosphorylation,RPS3
R11196 T13919 T13918 arg1Of phosphorylation,S209
R11197 T13922 T13921 arg1Of vitro,in
R11198 T13922 T13923 arg1Of vitro,and
R11199 T13923 T13920 arg1Of and,both
R11200 T13925 T13923 arg2Of vivo,and
R11201 T13925 T13924 arg1Of vivo,in
R11202 T13929 T13928 arg2Of benefit,might
R11203 T13931 T13929 arg2Of bacterium,benefit
R11204 T13931 T13930 arg1Of bacterium,the
R11205 T13931 T13932 arg1Of bacterium,in
R11206 T13933 T13934 arg1Of colonization,and
R11207 T13934 T13932 arg2Of and,in
R11208 T13935 T13934 arg2Of transmission,and
R11926 T14935 T14934 arg1Of steers,NleH1
R11927 T14935 T14937 arg1Of steers,IKKβ
R11928 T14937 T14936 arg1Of IKKβ,the
R11929 T14939 T14935 arg1Of specificities,steers
R11930 T14939 T14938 arg1Of specificities,substrate
R11931 T14940 T14941 arg1Of NleH1,is
R11932 T14945 T14941 arg2Of kinase,is
R11933 T14945 T14942 arg1Of kinase,an
R11934 T14945 T14943 arg2Of kinase,autophosphorylated
R11935 T14945 T14944 arg1Of kinase,serine-threonine
R11936 T14945 T14946 arg1Of kinase,","
R11937 T14945 T14947 arg1Of kinase,which
R11938 T14945 T14948 arg1Of kinase,depends
R11939 T14948 T14949 arg1Of depends,on
R11940 T14951 T14949 arg2Of lysine,on
R11941 T14951 T14950 arg1Of lysine,the
R11942 T14951 T14952 arg1Of lysine,159
R11943 T14951 T14953 arg1Of lysine,(
R11944 T14951 T14956 arg1Of lysine,9
R11945 T14954 T14953 arg2Of K159,(
R11946 T14955 T14953 arg3Of ),(
R11947 T14958 T14957 arg1Of explore,To
R11948 T14960 T14958 arg2Of mechanism,explore
R11949 T14960 T14959 arg1Of mechanism,the
R11950 T14960 T14961 arg2Of mechanism,by
R11951 T14960 T14962 arg1Of mechanism,which
R11952 T14963 T14964 arg1Of NleH1,inhibits
R11953 T14964 T14961 arg1Of inhibits,by
R11954 T14967 T14964 arg2Of phosphorylation,inhibits
R11955 T14967 T14965 arg1Of phosphorylation,RPS3
R11956 T14967 T14966 arg1Of phosphorylation,S209
R11957 T14969 T14958 arg1Of we,explore
R11958 T14969 T14971 arg1Of we,performed
R11959 T14971 T14957 modOf performed,To
R11960 T14971 T14968 arg1Of performed,","
R11961 T14971 T14970 arg1Of performed,first
R11962 T14971 T14990 arg1Of performed,","
R11963 T14971 T14991 modOf performed,confirming
R11964 T14974 T14973 arg1Of vitro,in
R11965 T14976 T14971 arg2Of assay,performed
R11966 T14976 T14972 arg1Of assay,an
R11967 T14976 T14974 arg1Of assay,vitro
R11968 T14976 T14975 arg1Of assay,kinase
R11969 T14976 T14977 arg1Of assay,with
R11970 T14981 T14978 arg2Of protein,purified
R11971 T14981 T14979 arg1Of protein,wild-type
R11972 T14981 T14980 arg1Of protein,His-NleH1
R11973 T14981 T14982 arg1Of protein,and
R11974 T14982 T14977 arg2Of and,with
R11975 T14987 T14986 arg2Of K159A,(
R11976 T14988 T14986 arg3Of ),(
R11977 T14989 T14982 arg2Of protein,and
R11978 T14989 T14983 arg1Of protein,a
R11979 T14989 T14984 arg1Of protein,mutant
R11980 T14989 T14985 arg1Of protein,His-NleH1
R11981 T14989 T14986 arg1Of protein,(
R11982 T14993 T14994 arg1Of NleH1,is
R11983 T14993 T14995 arg2Of NleH1,autophosphorylated
R11984 T14995 T14994 arg2Of autophosphorylated,is
R11985 T14995 T14996 arg1Of autophosphorylated,and
R11986 T14996 T14991 arg2Of and,confirming
R11987 T14996 T14992 arg1Of and,that
R11988 T14998 T14997 arg1Of K159A,the
R11989 T14998 T14999 arg1Of K159A,is
R11990 T14999 T14996 arg2Of is,and
R11991 T15003 T14999 arg2Of mutant,is
R11992 T15003 T15000 arg1Of mutant,an
R11993 T15003 T15001 arg1Of mutant,NleH1
R11994 T15003 T15002 arg1Of mutant,kinase-dead
R11995 T15003 T15004 arg1Of mutant,(
R11996 T15006 T15004 arg2Of 7a,(
R11997 T15006 T15005 arg1Of 7a,Fig.
R11998 T15007 T15004 arg3Of ),(
R11999 T15009 T15008 arg1Of examine,To
R12000 T15013 T15011 arg1Of activity,the
R12001 T15013 T15012 arg1Of activity,kinase
R12002 T15013 T15014 arg1Of activity,is
R12003 T15013 T15015 arg2Of activity,required
R12004 T15015 T15009 arg2Of required,examine
R12005 T15015 T15010 arg1Of required,whether
R12006 T15015 T15014 arg2Of required,is
R12007 T15015 T15016 arg1Of required,for
R12008 T15015 T15018 modOf required,to
R12009 T15017 T15016 arg2Of NleH1,for
R12010 T15019 T15018 arg1Of inhibit,to
R12011 T15021 T15019 arg2Of phosphorlyation,inhibit
R12012 T15021 T15020 arg1Of phosphorlyation,IKKβ
R12013 T15021 T15022 arg1Of phosphorlyation,of
R12014 T15021 T15024 arg1Of phosphorlyation,on
R12015 T15023 T15022 arg2Of RPS3,of
R12016 T15025 T15024 arg2Of S209,on
R12017 T15027 T15029 arg1Of we,expressing
R12018 T15029 T15008 modOf expressing,To
R12019 T15029 T15026 arg1Of expressing,","
R12020 T15029 T15028 arg1Of expressing,ectopically
R12021 T15031 T15032 arg1Of wild-type,or
R12022 T15032 T15030 arg1Of or,either
R12023 T15033 T15032 arg2Of K159A,or
R12024 T15034 T15029 arg2Of NleH1,expressing
R12025 T15034 T15031 arg1Of NleH1,wild-type
R12026 T15034 T15033 arg1Of NleH1,K159A
R12027 T15034 T15035 arg1Of NleH1,in
R12028 T15037 T15035 arg2Of cells,in
R12029 T15037 T15036 arg1Of cells,293T
R12030 T15040 T15038 arg1Of expression,Wild-type
R12031 T15040 T15039 arg1Of expression,NleH1
R12032 T15040 T15042 arg1Of expression,reduced
R12033 T15042 T15041 arg1Of reduced,significantly
R12034 T15042 T15047 arg1Of reduced,","
R12035 T15042 T15048 arg1Of reduced,whereas
R12036 T15046 T15042 arg2Of phosphorylation,reduced
R12037 T15046 T15043 arg1Of phosphorylation,TNF-induced
R12038 T15046 T15044 arg1Of phosphorylation,RPS3
R12039 T15046 T15045 arg1Of phosphorylation,S209
R12040 T15051 T15049 arg1Of mutant,the
R12041 T15051 T15050 arg1Of mutant,K159A
R12042 T15051 T15052 arg1Of mutant,failed
R12043 T15051 T15054 arg1Of mutant,do
R12044 T15051 T15055 arg1Of mutant,so
R12045 T15052 T15048 arg2Of failed,whereas
R12046 T15052 T15056 arg1Of failed,(
R12047 T15054 T15052 arg2Of do,failed
R12048 T15054 T15053 arg1Of do,to
R12049 T15055 T15054 arg2Of so,do
R12050 T15058 T15056 arg2Of 7b,(
R12051 T15058 T15057 arg1Of 7b,Fig.
R12052 T15059 T15056 arg3Of ),(
R12053 T15063 T15061 arg1Of activity,NleH1
R12054 T15063 T15062 arg1Of activity,kinase
R12055 T15063 T15064 arg1Of activity,is
R12056 T15063 T15065 arg2Of activity,required
R12057 T15065 T15060 arg1Of required,Thus
R12058 T15065 T15064 arg2Of required,is
R12059 T15065 T15066 modOf required,to
R12060 T15067 T15066 arg1Of protect,to
R12061 T15067 T15069 arg1Of protect,from
R12062 T15068 T15067 arg2Of RPS3,protect
R12063 T15071 T15069 arg2Of phosphorylation,from
R12064 T15071 T15070 arg1Of phosphorylation,IKKβ-mediated
R12065 T15073 T15072 arg1Of rodentium,Citrobacter
R12066 T15073 T15074 arg1Of rodentium,is
R12067 T15074 T15092 arg1Of is,","
R12068 T15077 T15074 arg2Of pathogen,is
R12069 T15077 T15075 arg1Of pathogen,a
R12070 T15077 T15076 arg1Of pathogen,mouse
R12071 T15077 T15078 arg1Of pathogen,that
R12072 T15077 T15079 arg1Of pathogen,shares
R12073 T15079 T15086 arg1Of shares,","
R12074 T15079 T15089 arg1Of shares,for
R12075 T15081 T15079 arg2Of strategies,shares
R12076 T15081 T15080 arg1Of strategies,pathogenic
R12077 T15081 T15082 arg1Of strategies,with
R12078 T15084 T15082 arg2Of coli,with
R12079 T15084 T15083 arg1Of coli,E.
R12080 T15084 T15085 arg1Of coli,39
R12081 T15088 T15087 arg1Of notably,most
R12082 T15089 T15088 arg1Of for,notably
R12083 T15091 T15089 arg2Of investigation,for
R12084 T15091 T15090 arg1Of investigation,our
R12085 T15095 T15093 arg1Of NleH,C.
R12086 T15095 T15094 arg1Of NleH,rodentium
R12087 T15095 T15096 arg1Of NleH,inhibited
R12088 T15096 T15092 arg2Of inhibited,","
R12089 T15099 T15097 arg1Of translocation,RPS3
R12090 T15099 T15098 arg1Of translocation,nuclear
R12091 T15099 T15100 arg1Of translocation,and
R12092 T15100 T15096 arg2Of and,inhibited
R12093 T15100 T15105 arg1Of and,to
R12094 T15104 T15100 arg2Of activity,and
R12095 T15104 T15101 arg1Of activity,RPS3-dependent
R12096 T15104 T15102 arg1Of activity,NF-κB
R12097 T15104 T15103 arg1Of activity,luciferase
R12098 T15107 T15105 arg2Of extent,to
R12099 T15107 T15106 arg1Of extent,an
R12100 T15107 T15108 arg1Of extent,equivalent
R12101 T15108 T15109 arg1Of equivalent,to
R12102 T15112 T15109 arg2Of NleH1,to
R12103 T15112 T15110 arg1Of NleH1,E.
R12104 T15112 T15111 arg1Of NleH1,coli
R12105 T15114 T15096 arg3Of ref,inhibited
R12106 T15114 T15113 arg1Of ref,(
R12107 T15115 T15116 arg1Of 9,)
R12108 T15117 T15118 arg1Of We,assayed
R12109 T15118 T15122 arg1Of assayed,in
R12110 T15121 T15118 arg2Of phosphorylation,assayed
R12111 T15121 T15119 arg1Of phosphorylation,RPS3
R12112 T15121 T15120 arg1Of phosphorylation,S209
R12113 T15124 T15122 arg2Of cells,in
R12114 T15124 T15123 arg1Of cells,HeLa
R12115 T15124 T15125 arg2Of cells,infected
R12116 T15125 T15126 arg1Of infected,with
R12117 T15130 T15126 arg2Of strains,with
R12118 T15130 T15127 arg1Of strains,different
R12119 T15130 T15128 arg1Of strains,C.
R12120 T15130 T15129 arg1Of strains,rodentium
R12121 T15133 T15131 arg2Of cells,In
R12122 T15133 T15132 arg1Of cells,uninfected
R12123 T15135 T15136 arg1Of TNF-treatment,stimulated
R12124 T15136 T15131 arg1Of stimulated,In
R12125 T15136 T15134 arg1Of stimulated,","
R12126 T15139 T15136 arg2Of increase,stimulated
R12127 T15139 T15137 arg1Of increase,a
R12128 T15139 T15138 arg1Of increase,∼3.5-fold
R12129 T15139 T15140 arg1Of increase,in
R12130 T15143 T15140 arg2Of phosphorylation,in
R12131 T15143 T15141 arg1Of phosphorylation,RPS3
R12132 T15143 T15142 arg1Of phosphorylation,S209
R12133 T15143 T15144 arg1Of phosphorylation,(
R12134 T15146 T15144 arg2Of 7c,(
R12135 T15146 T15145 arg1Of 7c,Fig.
R12136 T15147 T15144 arg3Of ),(
R12137 T15149 T15148 arg1Of augmentation,Such
R12138 T15149 T15150 arg1Of augmentation,of
R12139 T15149 T15153 arg1Of augmentation,was
R12140 T15149 T15154 arg2Of augmentation,reduced
R12141 T15152 T15150 arg2Of phosphorylation,of
R12142 T15152 T15151 arg1Of phosphorylation,RPS3
R12143 T15154 T15153 arg2Of reduced,was
R12144 T15154 T15155 arg1Of reduced,by
R12145 T15157 T15156 arg1Of 60,about
R12146 T15158 T15155 arg2Of %,by
R12147 T15158 T15157 arg1Of %,60
R12148 T15163 T15154 arg1Of infection,reduced
R12149 T15163 T15159 arg2Of infection,by
R12150 T15163 T15160 arg1Of infection,wild-type
R12151 T15163 T15161 arg1Of infection,C.
R12152 T15163 T15162 arg1Of infection,rodentium
R12153 T15163 T15164 arg1Of infection,(
R12154 T15166 T15164 arg2Of 7c,(
R12155 T15166 T15165 arg1Of 7c,Fig.
R12156 T15167 T15164 arg3Of ),(
R12157 T15171 T15170 arg1Of phosphorylation,RPS3
R12158 T15171 T15172 arg1Of phosphorylation,was
R12159 T15171 T15173 arg2Of phosphorylation,enhanced
R12160 T15173 T15168 arg1Of enhanced,However
R12161 T15173 T15169 arg1Of enhanced,","
R12162 T15173 T15172 arg2Of enhanced,was
R12163 T15173 T15174 arg1Of enhanced,when
R12164 T15175 T15176 arg1Of cells,were
R12165 T15175 T15177 arg2Of cells,infected
R12166 T15177 T15174 arg2Of infected,when
R12167 T15177 T15176 arg2Of infected,were
R12168 T15177 T15178 arg1Of infected,with
R12169 T15182 T15178 arg2Of strain,with
R12170 T15182 T15179 arg1Of strain,a
R12171 T15182 T15180 arg1Of strain,C.
R12172 T15182 T15181 arg1Of strain,rodentium
R12173 T15182 T15183 arg1Of strain,lacking
R12174 T15184 T15183 arg2Of NleH,lacking
R12175 T15184 T15185 arg1Of NleH,(
R12176 T15187 T15185 arg2Of 7c,(
R12177 T15187 T15186 arg1Of 7c,Fig.
R12178 T15187 T15188 arg1Of 7c,","
R12179 T15189 T15188 arg2Of ΔnleH,","
R12180 T15190 T15185 arg3Of ),(
R12181 T15191 T15193 arg1Of We,examined
R12182 T15193 T15192 arg1Of examined,further
R12183 T15195 T15193 arg2Of role,examined
R12184 T15195 T15194 arg1Of role,the
R12185 T15195 T15196 arg1Of role,of
R12186 T15195 T15200 arg1Of role,using
R12187 T15199 T15196 arg2Of activity,of
R12188 T15199 T15197 arg1Of activity,NleH1
R12189 T15199 T15198 arg1Of activity,kinase
R12190 T15200 T15206 arg1Of using,as
R12191 T15205 T15200 arg2Of strain,using
R12192 T15205 T15201 arg1Of strain,the
R12193 T15205 T15202 arg1Of strain,C.
R12194 T15205 T15203 arg1Of strain,rodentium
R12195 T15205 T15204 arg1Of strain,ΔnleH
R12196 T15208 T15206 arg2Of background,as
R12197 T15208 T15207 arg1Of background,a
R12198 T15208 T15209 arg1Of background,on
R12199 T15210 T15209 arg2Of which,on
R12200 T15210 T15213 arg2Of which,either
R12201 T15212 T15211 arg1Of express,to
R12202 T15212 T15213 arg1Of express,either
R12203 T15214 T15215 arg1Of wild-type,or
R12204 T15215 T15212 arg2Of or,express
R12205 T15219 T15215 arg2Of NleH1,or
R12206 T15219 T15216 arg1Of NleH1,K159A
R12207 T15219 T15217 arg1Of NleH1,E.
R12208 T15219 T15218 arg1Of NleH1,coli
R12209 T15222 T15220 arg1Of mutant,Complementing
R12210 T15222 T15221 arg1Of mutant,ΔnleH
R12211 T15222 T15223 arg1Of mutant,with
R12212 T15222 T15227 arg1Of mutant,abolished
R12213 T15225 T15223 arg2Of NleH1,with
R12214 T15225 T15224 arg1Of NleH1,wild-type
R12215 T15227 T15226 arg1Of abolished,almost
R12216 T15227 T15232 arg1Of abolished,whereas
R12217 T15231 T15227 arg2Of phosphorylation,abolished
R12218 T15231 T15228 arg1Of phosphorylation,TNF-induced
R12219 T15231 T15229 arg1Of phosphorylation,RPS3
R12220 T15231 T15230 arg1Of phosphorylation,S209
R12221 T15233 T15234 arg1Of complementing,with
R12222 T15233 T15236 arg1Of complementing,failed
R12223 T15233 T15238 arg1Of complementing,inhibit
R12224 T15235 T15234 arg2Of K159A,with
R12225 T15236 T15232 arg2Of failed,whereas
R12226 T15238 T15236 arg2Of inhibit,failed
R12227 T15238 T15237 arg1Of inhibit,to
R12228 T15240 T15238 arg2Of phosphorylation,inhibit
R12229 T15240 T15239 arg1Of phosphorylation,RPS3
R12230 T15240 T15241 arg1Of phosphorylation,(
R12231 T15243 T15241 arg2Of 7c,(
R12232 T15243 T15242 arg1Of 7c,Fig.
R12233 T15244 T15241 arg3Of ),(
R12234 T15248 T15247 arg1Of results,these
R12235 T15248 T15249 arg1Of results,demonstrate
R12236 T15249 T15245 arg1Of demonstrate,Collectively
R12237 T15249 T15246 arg1Of demonstrate,","
R12238 T15253 T15251 arg1Of activity,NleH1
R12239 T15253 T15252 arg1Of activity,kinase
R12240 T15253 T15254 arg1Of activity,is
R12241 T15253 T15255 arg2Of activity,required
R12242 T15253 T15257 arg1Of activity,block
R12243 T15255 T15249 arg2Of required,demonstrate
R12244 T15255 T15250 arg1Of required,that
R12245 T15255 T15254 arg2Of required,is
R12246 T15257 T15255 arg3Of block,required
R12247 T15257 T15256 arg1Of block,to
R12248 T15260 T15257 arg2Of phosphorylation,block
R12249 T15260 T15258 arg1Of phosphorylation,RPS3
R12250 T15260 T15259 arg1Of phosphorylation,S209
R12251 T15261 T15263 arg1Of We,examined
R12252 T15263 T15262 arg1Of examined,next
R12253 T15267 T15265 arg1Of activity,the
R12254 T15267 T15266 arg1Of activity,inhibitory
R12255 T15267 T15268 arg1Of activity,of
R12256 T15267 T15270 arg1Of activity,is
R12257 T15267 T15272 arg1Of activity,robust
R12258 T15269 T15268 arg2Of NleH1,of
R12259 T15270 T15263 arg2Of is,examined
R12260 T15270 T15264 arg1Of is,whether
R12261 T15272 T15270 arg2Of robust,is
R12262 T15272 T15271 arg1Of robust,sufficiently
R12263 T15272 T15273 modOf robust,to
R12264 T15274 T15273 arg1Of impair,to
R12265 T15278 T15274 arg2Of translocation,impair
R12266 T15278 T15275 arg1Of translocation,the
R12267 T15278 T15276 arg1Of translocation,strong
R12268 T15278 T15277 arg1Of translocation,nuclear
R12269 T15278 T15279 arg1Of translocation,of
R12270 T15280 T15279 arg2Of RPS3,of
R12271 T15280 T15281 arg2Of RPS3,trigged
R12272 T15281 T15292 arg1Of trigged,(
R12273 T15285 T15281 arg1Of IKKβ,trigged
R12274 T15285 T15282 arg2Of IKKβ,by
R12275 T15285 T15283 arg1Of IKKβ,the
R12276 T15285 T15284 arg1Of IKKβ,constitutively-active
R12277 T15285 T15286 arg1Of IKKβ,(
R12278 T15287 T15286 arg2Of IKKβ,(
R12279 T15287 T15288 arg1Of IKKβ,[
R12280 T15289 T15288 arg2Of SSEE,[
R12281 T15290 T15288 arg3Of ],[
R12282 T15291 T15286 arg3Of ),(
R12283 T15294 T15292 arg2Of 2d,(
R12284 T15294 T15293 arg1Of 2d,Fig.
R12285 T15295 T15292 arg3Of ),(
R12286 T15296 T15297 arg1Of We,found
R12287 T15300 T15299 arg2Of expressing,ectopically
R12288 T15300 T15301 arg1Of expressing,either
R12289 T15302 T15303 arg1Of wild-type,or
R12290 T15303 T15300 arg1Of or,expressing
R12291 T15303 T15308 arg1Of or,triggered
R12292 T15306 T15303 arg2Of proteins,or
R12293 T15306 T15304 arg1Of proteins,SSEE
R12294 T15306 T15305 arg1Of proteins,IKKβ
R12295 T15308 T15297 arg2Of triggered,found
R12296 T15308 T15298 arg1Of triggered,that
R12297 T15308 T15299 arg1Of triggered,ectopically
R12298 T15308 T15307 arg1Of triggered,","
R12299 T15312 T15308 arg2Of translocation,triggered
R12300 T15312 T15309 arg1Of translocation,more
R12301 T15312 T15310 arg1Of translocation,RPS3
R12302 T15312 T15311 arg1Of translocation,nuclear
R12303 T15312 T15313 arg1Of translocation,than
R12304 T15318 T15317 arg2Of SSAA,(
R12305 T15319 T15317 arg3Of ),(
R12306 T15320 T15313 arg2Of protein,than
R12307 T15320 T15314 arg1Of protein,the
R12308 T15320 T15315 arg1Of protein,kinase-dead
R12309 T15320 T15316 arg1Of protein,IKKβ
R12310 T15320 T15317 arg1Of protein,(
R12311 T15320 T15321 arg1Of protein,(
R12312 T15323 T15321 arg2Of 7d,(
R12313 T15323 T15322 arg1Of 7d,Fig.
R12314 T15324 T15321 arg3Of ),(
R12315 T15327 T15325 arg1Of accumulation,RPS3
R12316 T15327 T15326 arg1Of accumulation,nuclear
R12317 T15327 T15328 arg1Of accumulation,was
R12318 T15327 T15330 arg2Of accumulation,retarded
R12319 T15330 T15328 arg2Of retarded,was
R12320 T15330 T15329 arg1Of retarded,substantially
R12321 T15330 T15331 arg1Of retarded,by
R12322 T15332 T15331 arg2Of infecting,by
R12323 T15332 T15334 arg1Of infecting,with
R12324 T15333 T15332 arg2Of cells,infecting
R12325 T15338 T15335 arg1Of O157,wild-type
R12326 T15338 T15336 arg1Of O157,E.
R12327 T15338 T15337 arg1Of O157,coli
R12328 T15338 T15339 arg1Of O157,:
R12329 T15339 T15334 arg2Of :,with
R12330 T15340 T15339 arg2Of H7,:
R12331 T15340 T15341 arg1Of H7,(
R12332 T15343 T15341 arg2Of 7d,(
R12333 T15343 T15342 arg1Of 7d,Fig.
R12334 T15344 T15341 arg3Of ),(
R12335 T15346 T15345 arg2Of contrast,In
R12336 T15348 T15345 arg1Of infecting,In
R12337 T15348 T15347 arg1Of infecting,","
R12338 T15348 T15349 arg1Of infecting,with
R12339 T15351 T15352 arg1Of ΔnleH1,or
R12340 T15352 T15349 arg2Of or,with
R12341 T15352 T15350 arg1Of or,either
R12342 T15352 T15361 arg1Of or,in
R12343 T15356 T15355 arg1Of slightly,only
R12344 T15357 T15356 arg1Of impaired,slightly
R12345 T15360 T15352 arg2Of translocation,or
R12346 T15360 T15353 arg1Of translocation,ΔescN
R12347 T15360 T15354 arg1Of translocation,strains
R12348 T15360 T15357 arg1Of translocation,impaired
R12349 T15360 T15358 arg1Of translocation,RPS3
R12350 T15360 T15359 arg1Of translocation,nuclear
R12351 T15363 T15364 arg1Of IKKβ-,or
R12352 T15364 T15361 arg2Of or,in
R12353 T15364 T15362 arg1Of or,either
R12354 T15367 T15366 arg2Of SSEE,(
R12355 T15368 T15366 arg3Of ),(
R12356 T15370 T15364 arg2Of cells,or
R12357 T15370 T15365 arg1Of cells,IKKβ
R12358 T15370 T15366 arg1Of cells,(
R12359 T15370 T15369 arg1Of cells,-expressing
R12360 T15370 T15371 arg1Of cells,(
R12361 T15373 T15371 arg2Of 7d,(
R12362 T15373 T15372 arg1Of 7d,Fig.
R12363 T15374 T15371 arg3Of ),(
R12364 T15376 T15375 arg2Of expected,As
R12365 T15379 T15378 arg1Of coli,E.
R12366 T15380 T15379 arg1Of infections,coli
R12367 T15380 T15381 arg1Of infections,did
R12368 T15380 T15383 arg1Of infections,affect
R12369 T15383 T15375 arg1Of affect,As
R12370 T15383 T15377 arg1Of affect,","
R12371 T15383 T15381 arg2Of affect,did
R12372 T15383 T15382 arg1Of affect,not
R12373 T15387 T15383 arg2Of translocation,affect
R12374 T15387 T15384 arg1Of translocation,the
R12375 T15387 T15385 arg1Of translocation,RPS3
R12376 T15387 T15386 arg1Of translocation,nuclear
R12377 T15387 T15388 arg1Of translocation,in
R12378 T15391 T15390 arg2Of SSAA,(
R12379 T15392 T15390 arg3Of ),(
R12380 T15394 T15388 arg2Of cells,in
R12381 T15394 T15389 arg1Of cells,IKKβ
R12382 T15394 T15390 arg1Of cells,(
R12383 T15394 T15393 arg1Of cells,-expressing
R12384 T15394 T15395 arg1Of cells,","
R12385 T15394 T15396 arg1Of cells,where
R12386 T15394 T15401 arg1Of cells,(
R12387 T15398 T15397 arg1Of signaling,NF-κB
R12388 T15398 T15399 arg1Of signaling,was
R12389 T15398 T15400 arg1Of signaling,low
R12390 T15399 T15396 arg2Of was,where
R12391 T15400 T15399 arg2Of low,was
R12392 T15403 T15401 arg2Of 7d,(
R12393 T15403 T15402 arg1Of 7d,Fig.
R12394 T15404 T15401 arg3Of ),(
R12395 T15408 T15407 arg2Of infection,during
R12396 T15409 T15410 arg1Of NleH1,is
R12397 T15409 T15412 arg1Of NleH1,potent
R12398 T15410 T15405 arg1Of is,Thus
R12399 T15410 T15406 arg1Of is,","
R12400 T15410 T15407 arg1Of is,during
R12401 T15412 T15410 arg2Of potent,is
R12402 T15412 T15411 arg1Of potent,sufficiently
R12403 T15412 T15413 modOf potent,to
R12404 T15414 T15413 arg1Of inhibit,to
R12405 T15414 T15419 arg1Of inhibit,in
R12406 T15417 T15414 arg2Of translocation,inhibit
R12407 T15417 T15415 arg1Of translocation,RPS3
R12408 T15417 T15416 arg1Of translocation,nuclear
R12409 T15419 T15418 arg1Of in,even
R12410 T15420 T15419 arg2Of cells,in
R12411 T15420 T15421 arg1Of cells,expressing
R12412 T15423 T15421 arg2Of IKKβ,expressing
R12413 T15423 T15422 arg1Of IKKβ,constitutively-activated
R12414 T15424 T15425 arg1Of We,examined
R12415 T15427 T15428 arg1Of NleH1,could
R12416 T15427 T15430 arg1Of NleH1,phosphorylate
R12417 T15430 T15425 arg2Of phosphorylate,examined
R12418 T15430 T15426 arg1Of phosphorylate,whether
R12419 T15430 T15428 arg2Of phosphorylate,could
R12420 T15430 T15429 arg1Of phosphorylate,directly
R12421 T15431 T15430 arg2Of IKKβ,phosphorylate
R12422 T15431 T15433 arg1Of IKKβ,inhibiting
R12423 T15433 T15432 arg1Of inhibiting,thus
R12424 T15437 T15433 arg2Of phosphorylation,inhibiting
R12425 T15437 T15434 arg1Of phosphorylation,IKKβ-mediated
R12426 T15437 T15435 arg1Of phosphorylation,RPS3
R12427 T15437 T15436 arg1Of phosphorylation,S209
R12428 T15438 T15439 arg1Of We,performed
R12429 T15439 T15450 arg1Of performed,as
R12430 T15439 T15457 arg1Of performed,","
R12431 T15439 T15458 arg1Of performed,so
R12432 T15441 T15440 arg1Of vitro,in
R12433 T15443 T15439 arg2Of assays,performed
R12434 T15443 T15441 arg1Of assays,vitro
R12435 T15443 T15442 arg1Of assays,kinase
R12436 T15443 T15444 arg1Of assays,using
R12437 T15446 T15444 arg2Of Flag-IKKβ,using
R12438 T15446 T15445 arg2Of Flag-IKKβ,immunoprecipitated
R12439 T15446 T15447 arg1Of Flag-IKKβ,(
R12440 T15448 T15447 arg2Of K44A,(
R12441 T15449 T15447 arg3Of ),(
R12442 T15451 T15452 arg1Of substrate,and
R12443 T15452 T15450 arg2Of and,as
R12444 T15452 T15455 arg1Of and,as
R12445 T15454 T15452 arg2Of His-NleH1,and
R12446 T15454 T15453 arg1Of His-NleH1,recombinant
R12447 T15456 T15455 arg2Of kinase,as
R12448 T15458 T15459 arg1Of so,that
R12449 T15461 T15460 arg1Of autophosphorylation,IKKβ
R12450 T15461 T15462 arg1Of autophosphorylation,would
R12451 T15461 T15464 arg1Of autophosphorylation,obscure
R12452 T15464 T15458 arg2Of obscure,so
R12453 T15464 T15462 arg2Of obscure,would
R12454 T15464 T15463 arg1Of obscure,not
R12455 T15466 T15464 arg2Of phosphorylation,obscure
R12456 T15466 T15465 arg1Of phosphorylation,NleH1-induced
R12457 T15469 T15470 arg1Of we,did
R12458 T15469 T15472 arg1Of we,observe
R12459 T15469 T15486 arg1Of we,ruling
R12460 T15472 T15467 arg1Of observe,However
R12461 T15472 T15468 arg1Of observe,","
R12462 T15472 T15470 arg2Of observe,did
R12463 T15472 T15471 arg1Of observe,not
R12464 T15472 T15477 arg1Of observe,in
R12465 T15472 T15484 arg1Of observe,","
R12466 T15472 T15486 modOf observe,ruling
R12467 T15476 T15472 arg2Of incorporation,observe
R12468 T15476 T15473 arg1Of incorporation,any
R12469 T15476 T15474 arg1Of incorporation,detectable
R12470 T15476 T15475 arg1Of incorporation,32P
R12471 T15478 T15477 arg2Of IKKβ,in
R12472 T15478 T15479 arg1Of IKKβ,(
R12473 T15481 T15479 arg2Of Fig.,(
R12474 T15481 T15480 arg1Of Fig.,Supplementary
R12475 T15481 T15482 arg1Of Fig.,13
R12476 T15483 T15479 arg3Of ),(
R12477 T15486 T15485 arg1Of ruling,thus
R12478 T15486 T15487 arg1Of ruling,out
R12479 T15489 T15486 arg2Of possibility,ruling
R12480 T15489 T15488 arg1Of possibility,this
R12481 T15490 T15492 arg1Of We,tested
R12482 T15492 T15491 arg1Of tested,then
R12483 T15494 T15492 arg2Of hypothesis,tested
R12484 T15494 T15493 arg1Of hypothesis,the
R12485 T15496 T15497 arg1Of NleH1,could
R12486 T15496 T15498 arg1Of NleH1,alter
R12487 T15498 T15494 arg2Of alter,hypothesis
R12488 T15498 T15495 arg1Of alter,that
R12489 T15498 T15497 arg2Of alter,could
R12490 T15502 T15498 arg2Of specificities,alter
R12491 T15502 T15499 arg1Of specificities,the
R12492 T15502 T15500 arg1Of specificities,IKKβ
R12493 T15502 T15501 arg1Of specificities,substrate
R12494 T15505 T15503 arg2Of end,To
R12495 T15505 T15504 arg1Of end,this
R12496 T15507 T15508 arg1Of we,performed
R12497 T15508 T15503 arg1Of performed,To
R12498 T15508 T15506 arg1Of performed,","
R12499 T15510 T15509 arg1Of vitro,in
R12500 T15512 T15508 arg2Of assays,performed
R12501 T15512 T15510 arg1Of assays,vitro
R12502 T15512 T15511 arg1Of assays,kinase
R12503 T15512 T15513 arg1Of assays,using
R12504 T15515 T15516 arg1Of CK2,and
R12505 T15517 T15516 arg2Of IKK,and
R12506 T15518 T15513 arg2Of substrates,using
R12507 T15518 T15514 arg1Of substrates,both
R12508 T15518 T15515 arg1Of substrates,CK2
R12509 T15518 T15517 arg1Of substrates,IKK
R12510 T15518 T15519 arg1Of substrates,for
R12511 T15520 T15519 arg2Of IKKβ,for
R12512 T15522 T15521 arg2Of expected,As
R12513 T15526 T15524 arg1Of RPS3,IKKβ
R12514 T15526 T15525 arg2Of RPS3,phosphorylated
R12515 T15526 T15527 arg1Of RPS3,(
R12516 T15526 T15534 arg1Of RPS3,and
R12517 T15529 T15527 arg2Of 7e,(
R12518 T15529 T15528 arg1Of 7e,Fig.
R12519 T15529 T15530 arg1Of 7e,","
R12520 T15531 T15530 arg2Of lane,","
R12521 T15531 T15532 arg1Of lane,7
R12522 T15533 T15527 arg3Of ),(
R12523 T15534 T15540 arg1Of and,(
R12524 T15534 T15548 arg1Of and,demonstrating
R12525 T15537 T15536 arg2Of 1-54,(
R12526 T15538 T15536 arg3Of ),(
R12527 T15539 T15534 arg2Of protein,and
R12528 T15539 T15535 arg1Of protein,GST-IκBα
R12529 T15539 T15536 arg1Of protein,(
R12530 T15542 T15540 arg2Of 7e,(
R12531 T15542 T15541 arg1Of 7e,Fig.
R12532 T15542 T15543 arg1Of 7e,","
R12533 T15544 T15543 arg2Of lane,","
R12534 T15544 T15545 arg1Of lane,9
R12535 T15546 T15540 arg3Of ),(
R12536 T15548 T15521 arg1Of demonstrating,As
R12537 T15548 T15523 arg1Of demonstrating,","
R12538 T15548 T15547 arg1Of demonstrating,","
R12539 T15549 T15550 arg1Of it,harbors
R12540 T15550 T15548 arg2Of harbors,demonstrating
R12541 T15552 T15553 arg1Of CK2,or
R12542 T15553 T15550 arg2Of or,harbors
R12543 T15553 T15551 arg1Of or,either
R12544 T15556 T15553 arg2Of specificity,or
R12545 T15556 T15554 arg1Of specificity,IKK
R12546 T15556 T15555 arg1Of specificity,substrate
R12547 T15557 T15558 arg1Of Preincubation,of
R12548 T15557 T15560 arg1Of Preincubation,with
R12549 T15557 T15562 arg1Of Preincubation,reduced
R12550 T15559 T15558 arg2Of IKKβ,of
R12551 T15561 T15560 arg2Of NleH1,with
R12552 T15565 T15563 arg1Of phosphorylation,IKKβ-mediated
R12553 T15565 T15564 arg1Of phosphorylation,RPS3
R12554 T15565 T15566 arg1Of phosphorylation,","
R12555 T15565 T15573 arg1Of phosphorylation,but
R12556 T15571 T15566 arg2Of specificity,","
R12557 T15571 T15567 arg1Of specificity,i.e.
R12558 T15571 T15568 arg1Of specificity,the
R12559 T15571 T15569 arg1Of specificity,CK2
R12560 T15571 T15570 arg1Of specificity,kinase
R12561 T15573 T15562 arg2Of but,reduced
R12562 T15573 T15572 arg1Of but,","
R12563 T15573 T15574 arg1Of but,not
R12564 T15577 T15573 arg2Of phosphorylation,but
R12565 T15577 T15575 arg1Of phosphorylation,IKKβ-mediated
R12566 T15577 T15576 arg1Of phosphorylation,GST-IκBα
R12567 T15577 T15578 arg1Of phosphorylation,","
R12568 T15583 T15578 arg2Of specificity,","
R12569 T15583 T15579 arg1Of specificity,i.e.
R12570 T15583 T15580 arg1Of specificity,the
R12571 T15583 T15581 arg1Of specificity,IKK
R12572 T15583 T15582 arg1Of specificity,kinase
R12573 T15583 T15584 arg1Of specificity,(
R12574 T15586 T15584 arg2Of 7e,(
R12575 T15586 T15585 arg1Of 7e,Fig.
R12576 T15587 T15584 arg3Of ),(
R12577 T15589 T15588 arg1Of experiments,Control
R12578 T15589 T15590 arg1Of experiments,revealed
R12579 T15593 T15592 arg1Of phosphorylation,NleH1-mediated
R12580 T15593 T15594 arg1Of phosphorylation,or
R12581 T15594 T15591 arg1Of or,no
R12582 T15594 T15598 arg1Of or,or
R12583 T15595 T15594 arg2Of autophosphorylation,or
R12584 T15595 T15596 arg1Of autophosphorylation,of
R12585 T15597 T15596 arg2Of RPS3,of
R12586 T15598 T15590 arg2Of or,revealed
R12587 T15599 T15598 arg2Of GST-IκBα,or
R12588 T15599 T15600 arg1Of GST-IκBα,(
R12589 T15602 T15600 arg2Of 7e,(
R12590 T15602 T15601 arg1Of 7e,Fig.
R12591 T15603 T15600 arg3Of ),(
R12592 T15604 T15605 arg1Of Taken,together
R12593 T15607 T15608 arg1Of NleH1,blocks
R12594 T15608 T15604 modOf blocks,Taken
R12595 T15608 T15606 arg1Of blocks,","
R12596 T15612 T15608 arg2Of specificity,blocks
R12597 T15612 T15609 arg1Of specificity,the
R12598 T15612 T15610 arg1Of specificity,CK2
R12599 T15612 T15611 arg1Of specificity,substrate
R12600 T15612 T15613 arg1Of specificity,of
R12601 T15614 T15613 arg2Of IKKβ,of
R12602 T15616 T15608 arg3Of inhibiting,blocks
R12603 T15616 T15615 arg1Of inhibiting,thus
R12604 T15621 T15616 arg2Of phosphorylation,inhibiting
R12605 T15621 T15617 arg1Of phosphorylation,the
R12606 T15621 T15618 arg1Of phosphorylation,IKKβ-mediated
R12607 T15621 T15619 arg1Of phosphorylation,RPS3
R12608 T15621 T15620 arg1Of phosphorylation,S209
R12609 T15621 T15623 arg1Of phosphorylation,representing
R12610 T15623 T15622 arg1Of representing,thus
R12611 T15623 T15626 arg1Of representing,strategy
R12612 T15623 T15627 arg1Of representing,by
R12613 T15623 T15631 arg1Of representing,:
R12614 T15626 T15624 arg1Of strategy,a
R12615 T15626 T15625 arg1Of strategy,novel
R12616 T15630 T15627 arg2Of O157,by
R12617 T15630 T15628 arg1Of O157,E.
R12618 T15630 T15629 arg1Of O157,coli
R12619 T15632 T15623 arg2Of H7,representing
R12620 T15632 T15633 modOf H7,to
R12621 T15634 T15633 arg1Of alter,to
R12622 T15639 T15634 arg2Of response,alter
R12623 T15639 T15635 arg1Of response,the
R12624 T15639 T15636 arg1Of response,host
R12625 T15639 T15637 arg1Of response,innate
R12626 T15639 T15638 arg1Of response,immune
R14406 T18146 T18147 arg1Of RPS3,was
R14407 T18146 T18149 arg2Of RPS3,demonstrated
R14408 T18146 T18151 arg1Of RPS3,function
R14409 T18149 T18147 arg2Of demonstrated,was
R14410 T18149 T18148 arg1Of demonstrated,previously
R14411 T18151 T18149 arg3Of function,demonstrated
R14412 T18151 T18150 arg1Of function,to
R14413 T18151 T18152 arg1Of function,as
R14414 T18155 T18152 arg2Of subunit,as
R14415 T18155 T18153 arg1Of subunit,an
R14416 T18155 T18154 arg1Of subunit,integral
R14417 T18155 T18156 arg1Of subunit,conferring
R14418 T18159 T18156 arg2Of specificity6,conferring
R14419 T18159 T18157 arg1Of specificity6,NF-κB
R14420 T18159 T18158 arg1Of specificity6,regulatory
R14421 T18161 T18162 arg1Of we,sought
R14422 T18161 T18164 arg1Of we,elucidate
R14423 T18162 T18160 arg1Of sought,Here
R14424 T18164 T18162 arg2Of elucidate,sought
R14425 T18164 T18163 arg1Of elucidate,to
R14426 T18165 T18164 arg2Of how,elucidate
R14427 T18168 T18166 arg1Of signaling,NF-κB
R14428 T18168 T18167 arg1Of signaling,activation
R14429 T18168 T18169 arg1Of signaling,triggers
R14430 T18169 T18165 arg1Of triggers,how
R14431 T18169 T18171 modOf triggers,to
R14432 T18170 T18169 arg2Of RPS3,triggers
R14433 T18172 T18173 arg1Of translocate,and
R14434 T18173 T18171 arg1Of and,to
R14435 T18174 T18173 arg2Of participate,and
R14436 T18174 T18175 arg1Of participate,in
R14437 T18177 T18172 arg2Of function,translocate
R14438 T18177 T18174 arg2Of function,participate
R14439 T18177 T18176 arg1Of function,NF-κB
R14440 T18177 T18178 arg1Of function,in
R14441 T18180 T18178 arg2Of nucleus,in
R14442 T18180 T18179 arg1Of nucleus,the
R14443 T18181 T18182 arg1Of We,demonstrate
R14444 T18187 T18184 arg1Of phosphorylation,IKKβ-mediated
R14445 T18187 T18185 arg1Of phosphorylation,RPS3
R14446 T18187 T18186 arg1Of phosphorylation,S209
R14447 T18187 T18188 arg1Of phosphorylation,represents
R14448 T18188 T18182 arg2Of represents,demonstrate
R14449 T18188 T18183 arg1Of represents,that
R14450 T18191 T18188 arg2Of determinant,represents
R14451 T18191 T18189 arg1Of determinant,a
R14452 T18191 T18190 arg1Of determinant,critical
R14453 T18191 T18192 arg1Of determinant,in
R14454 T18193 T18192 arg2Of governing,in
R14455 T18196 T18193 arg2Of import,governing
R14456 T18196 T18194 arg1Of import,its
R14457 T18196 T18195 arg1Of import,nuclear
R14458 T18196 T18198 arg1Of import,unveiling
R14459 T18198 T18197 arg1Of unveiling,thus
R14460 T18201 T18198 arg2Of mechanism,unveiling
R14461 T18201 T18199 arg1Of mechanism,a
R14462 T18201 T18200 arg1Of mechanism,novel
R14463 T18201 T18202 arg1Of mechanism,behind
R14464 T18205 T18202 arg2Of specificity,behind
R14465 T18205 T18203 arg1Of specificity,NF-κB
R14466 T18205 T18204 arg1Of specificity,regulatory
R14467 T18206 T18207 arg1Of IKKβ,is
R14468 T18210 T18207 arg2Of kinase,is
R14469 T18210 T18208 arg1Of kinase,the
R14470 T18210 T18209 arg1Of kinase,major
R14471 T18210 T18211 arg1Of kinase,that
R14472 T18210 T18212 arg1Of kinase,phosphorylates
R14473 T18212 T18214 arg1Of phosphorylates,in
R14474 T18212 T18219 arg1Of phosphorylates,","
R14475 T18212 T18220 modOf phosphorylates,leading
R14476 T18213 T18212 arg2Of IκBs,phosphorylates
R14477 T18218 T18214 arg2Of pathway,in
R14478 T18218 T18215 arg1Of pathway,the
R14479 T18218 T18216 arg1Of pathway,classical
R14480 T18218 T18217 arg1Of pathway,NF-κB
R14481 T18220 T18221 arg1Of leading,to
R14482 T18224 T18221 arg2Of degradation40,to
R14483 T18224 T18222 arg1Of degradation40,their
R14484 T18224 T18223 arg1Of degradation40,subsequent
R14485 T18227 T18228 arg1Of RPS3,possesses
R14486 T18228 T18225 arg1Of possesses,Strikingly
R14487 T18228 T18226 arg1Of possesses,","
R14488 T18228 T18234 arg1Of possesses,;
R14489 T18233 T18228 arg2Of motif,possesses
R14490 T18233 T18229 arg1Of motif,not
R14491 T18233 T18230 arg1Of motif,any
R14492 T18233 T18231 arg1Of motif,consensus
R14493 T18233 T18232 arg1Of motif,IKK
R14494 T18237 T18238 arg1Of S209,is
R14495 T18237 T18239 arg2Of S209,centered
R14496 T18239 T18234 arg2Of centered,;
R14497 T18239 T18235 arg1Of centered,instead
R14498 T18239 T18236 arg1Of centered,","
R14499 T18239 T18238 arg2Of centered,is
R14500 T18239 T18240 arg1Of centered,in
R14501 T18244 T18240 arg2Of motif,in
R14502 T18244 T18241 arg1Of motif,a
R14503 T18244 T18242 arg1Of motif,consensus
R14504 T18244 T18243 arg1Of motif,CK2
R14505 T18247 T18245 arg1Of observation,The
R14506 T18247 T18246 arg1Of observation,recent
R14507 T18250 T18249 arg1Of IKKβ,human
R14508 T18250 T18251 arg1Of IKKβ,displayed
R14509 T18251 T18247 arg2Of displayed,observation
R14510 T18251 T18248 arg1Of displayed,that
R14511 T18251 T18256 arg1Of displayed,with
R14512 T18255 T18251 arg2Of coincides,displayed
R14513 T18255 T18252 arg1Of coincides,CK2-like
R14514 T18255 T18253 arg1Of coincides,phosphorylation
R14515 T18255 T18254 arg1Of coincides,specificity29
R14516 T18261 T18257 arg1Of IKKβ,our
R14517 T18261 T18258 arg1Of IKKβ,evidence
R14518 T18261 T18259 arg1Of IKKβ,that
R14519 T18261 T18260 arg1Of IKKβ,recombinant
R14520 T18261 T18263 arg1Of IKKβ,but
R14521 T18263 T18256 arg2Of but,with
R14522 T18263 T18262 arg1Of but,","
R14523 T18263 T18264 arg1Of but,not
R14524 T18263 T18266 arg1Of but,","
R14525 T18265 T18263 arg2Of IKKα,but
R14526 T18268 T18266 arg2Of RPS3,","
R14527 T18268 T18267 arg2Of RPS3,phosphorylated
R14528 T18269 T18270 arg1Of We,found
R14529 T18272 T18271 arg1Of phosphorylation,this
R14530 T18272 T18273 arg1Of phosphorylation,is
R14531 T18273 T18270 arg2Of is,found
R14532 T18276 T18273 arg2Of modulation,is
R14533 T18276 T18274 arg1Of modulation,a
R14534 T18276 T18275 arg1Of modulation,critical
R14535 T18276 T18277 arg1Of modulation,for
R14536 T18280 T18278 arg1Of translocation,RPS3
R14537 T18280 T18279 arg1Of translocation,nuclear
R14538 T18280 T18281 arg1Of translocation,(
R14539 T18280 T18285 arg1Of translocation,and
R14540 T18282 T18281 arg2Of via,(
R14541 T18283 T18282 arg2Of importin-α,via
R14542 T18284 T18281 arg3Of ),(
R14543 T18285 T18277 arg2Of and,for
R14544 T18286 T18285 arg2Of engagement,and
R14545 T18286 T18287 arg1Of engagement,in
R14546 T18290 T18287 arg2Of transcription,in
R14547 T18290 T18288 arg1Of transcription,specific
R14548 T18290 T18289 arg1Of transcription,NF-κB
R14549 T18291 T18292 arg1Of CK2,was
R14550 T18291 T18294 arg2Of CK2,shown
R14551 T18291 T18296 arg1Of CK2,phosphorylate
R14552 T18291 T18300 arg1Of CK2,bind
R14553 T18291 T18303 arg1Of CK2,phosphorylate
R14554 T18294 T18292 arg2Of shown,was
R14555 T18294 T18293 arg1Of shown,previously
R14556 T18294 T18305 arg1Of shown,","
R14557 T18294 T18306 arg1Of shown,however
R14558 T18294 T18307 arg1Of shown,","
R14559 T18296 T18295 arg1Of phosphorylate,to
R14560 T18296 T18298 arg1Of phosphorylate,and
R14561 T18297 T18296 arg2Of p65,phosphorylate
R14562 T18298 T18294 arg3Of and,shown
R14563 T18300 T18301 arg1Of bind,to
R14564 T18300 T18302 arg1Of bind,and
R14565 T18302 T18298 arg2Of and,and
R14566 T18302 T18299 arg1Of and,to
R14567 T18303 T18302 arg2Of phosphorylate,and
R14568 T18304 T18303 arg2Of IKKβ41-43,phosphorylate
R14569 T18307 T18329 arg1Of ",",in
R14570 T18308 T18309 arg1Of we,ruled
R14571 T18309 T18307 arg2Of ruled,","
R14572 T18309 T18310 arg1Of ruled,out
R14573 T18309 T18324 arg1Of ruled,because
R14574 T18312 T18309 arg2Of possibility,ruled
R14575 T18312 T18311 arg1Of possibility,the
R14576 T18316 T18314 arg1Of CK2,the
R14577 T18316 T18315 arg1Of CK2,IKKβ-bound
R14578 T18316 T18317 arg1Of CK2,could
R14579 T18316 T18318 arg1Of CK2,account
R14580 T18318 T18312 arg2Of account,possibility
R14581 T18318 T18313 arg1Of account,that
R14582 T18318 T18317 arg2Of account,could
R14583 T18318 T18319 arg1Of account,for
R14584 T18323 T18319 arg2Of phosphorylation,for
R14585 T18323 T18320 arg1Of phosphorylation,the
R14586 T18323 T18321 arg2Of phosphorylation,observed
R14587 T18323 T18322 arg1Of phosphorylation,RPS3
R14588 T18326 T18325 arg1Of CK2,no
R14589 T18326 T18327 arg1Of CK2,was
R14590 T18326 T18328 arg2Of CK2,detected
R14591 T18328 T18324 arg2Of detected,because
R14592 T18328 T18327 arg2Of detected,was
R14593 T18332 T18329 arg2Of preparations,in
R14594 T18332 T18330 arg1Of preparations,the
R14595 T18332 T18331 arg1Of preparations,IKKβ
R14596 T18332 T18333 arg2Of preparations,used
R14597 T18333 T18334 arg1Of used,for
R14598 T18337 T18336 arg1Of vitro,in
R14599 T18339 T18334 arg2Of assay,for
R14600 T18339 T18335 arg1Of assay,the
R14601 T18339 T18337 arg1Of assay,vitro
R14602 T18339 T18338 arg1Of assay,kinase
R14603 T18341 T18343 arg1Of RPS3,harbors
R14604 T18343 T18340 arg2Of harbors,Because
R14605 T18343 T18342 arg1Of harbors,only
R14606 T18346 T18344 arg1Of motif,the
R14607 T18346 T18345 arg1Of motif,CK2
R14608 T18346 T18347 arg1Of motif,and
R14609 T18347 T18343 arg2Of and,harbors
R14610 T18352 T18347 arg2Of motif,and
R14611 T18352 T18348 arg1Of motif,not
R14612 T18352 T18349 arg1Of motif,a
R14613 T18352 T18350 arg1Of motif,traditional
R14614 T18352 T18351 arg1Of motif,IKK
R14615 T18357 T18354 arg1Of function,this
R14616 T18357 T18355 arg1Of function,RPS3
R14617 T18357 T18356 arg1Of function,regulatory
R14618 T18357 T18358 arg1Of function,could
R14619 T18357 T18359 arg1Of function,explain
R14620 T18359 T18340 arg1Of explain,Because
R14621 T18359 T18353 arg1Of explain,","
R14622 T18359 T18358 arg2Of explain,could
R14623 T18360 T18359 arg2Of why,explain
R14624 T18361 T18362 arg1Of IKK,harbors
R14625 T18362 T18360 arg1Of harbors,why
R14626 T18367 T18362 arg2Of capability,harbors
R14627 T18367 T18363 arg1Of capability,the
R14628 T18367 T18364 arg1Of capability,alternative
R14629 T18367 T18365 arg1Of capability,substrate
R14630 T18367 T18366 arg1Of capability,phosphorylation
R14631 T18369 T18368 arg1Of importantly,More
R14632 T18372 T18371 arg1Of study,our
R14633 T18372 T18373 arg1Of study,has
R14634 T18372 T18374 arg1Of study,elucidated
R14635 T18374 T18369 arg1Of elucidated,importantly
R14636 T18374 T18370 arg1Of elucidated,","
R14637 T18374 T18373 arg2Of elucidated,has
R14638 T18375 T18374 arg2Of how,elucidated
R14639 T18376 T18377 arg1Of RPS3,is
R14640 T18376 T18379 arg2Of RPS3,integrated
R14641 T18379 T18375 arg1Of integrated,how
R14642 T18379 T18377 arg2Of integrated,is
R14643 T18379 T18378 arg1Of integrated,biochemically
R14644 T18379 T18380 arg1Of integrated,into
R14645 T18379 T18384 arg1Of integrated,in
R14646 T18383 T18380 arg2Of signaling,into
R14647 T18383 T18381 arg1Of signaling,NF-κB
R14648 T18383 T18382 arg1Of signaling,activation
R14649 T18386 T18384 arg2Of manner,in
R14650 T18386 T18385 arg1Of manner,a
R14651 T18386 T18387 arg1Of manner,that
R14652 T18386 T18388 arg1Of manner,is
R14653 T18386 T18389 arg1Of manner,pivotal
R14654 T18389 T18388 arg2Of pivotal,is
R14655 T18389 T18390 arg1Of pivotal,for
R14656 T18392 T18390 arg2Of pathogenesis,for
R14657 T18392 T18391 arg1Of pathogenesis,the
R14658 T18392 T18393 arg1Of pathogenesis,of
R14659 T18392 T18399 arg1Of pathogenesis,:
R14660 T18398 T18393 arg2Of O157,of
R14661 T18398 T18394 arg1Of O157,foodborne
R14662 T18398 T18395 arg1Of O157,pathogen
R14663 T18398 T18396 arg1Of O157,E.
R14664 T18398 T18397 arg1Of O157,coli
R14665 T18400 T18399 arg2Of H7,:
R14666 T18404 T18401 arg1Of phosphorylation,IKKβ-mediated
R14667 T18404 T18402 arg1Of phosphorylation,RPS3
R14668 T18404 T18403 arg1Of phosphorylation,S209
R14669 T18404 T18405 arg1Of phosphorylation,is
R14670 T18408 T18405 arg2Of target,is
R14671 T18408 T18406 arg1Of target,a
R14672 T18408 T18407 arg1Of target,critical
R14673 T18408 T18409 arg2Of target,modulated
R14674 T18412 T18409 arg1Of pathogen,modulated
R14675 T18412 T18410 arg2Of pathogen,by
R14676 T18412 T18411 arg1Of pathogen,this
R14677 T18412 T18413 modOf pathogen,to
R14678 T18414 T18413 arg1Of subvert,to
R14679 T18417 T18414 arg2Of signaling,subvert
R14680 T18417 T18415 arg1Of signaling,host
R14681 T18417 T18416 arg1Of signaling,NF-κB
R14682 T18421 T18418 arg1Of NleH1,The
R14683 T18421 T18419 arg1Of NleH1,bacterial
R14684 T18421 T18420 arg1Of NleH1,effector
R14685 T18421 T18423 arg1Of NleH1,binds
R14686 T18421 T18433 arg1Of NleH1,suppresses
R14687 T18423 T18424 arg1Of binds,to
R14688 T18423 T18431 arg1Of binds,and
R14689 T18425 T18424 arg2Of RPS3,to
R14690 T18425 T18427 arg2Of RPS3,injected
R14691 T18427 T18426 arg1Of injected,once
R14692 T18427 T18428 arg1Of injected,into
R14693 T18430 T18428 arg2Of cells,into
R14694 T18430 T18429 arg1Of cells,host
R14695 T18431 T18422 arg1Of and,specifically
R14696 T18433 T18431 arg2Of suppresses,and
R14697 T18433 T18432 arg1Of suppresses,profoundly
R14698 T18434 T18435 arg1Of NF-κB,and
R14699 T18435 T18433 arg2Of and,suppresses
R14700 T18440 T18435 arg2Of responses9,and
R14701 T18440 T18436 arg1Of responses9,its
R14702 T18440 T18437 arg1Of responses9,attendant
R14703 T18440 T18438 arg1Of responses9,protective
R14704 T18440 T18439 arg1Of responses9,immune
R14705 T18442 T18441 arg1Of data,Our
R14706 T18442 T18444 arg1Of data,show
R14707 T18444 T18443 arg1Of show,now
R14708 T18446 T18448 arg1Of NleH1,inhibits
R14709 T18448 T18444 arg2Of inhibits,show
R14710 T18448 T18445 arg1Of inhibits,that
R14711 T18448 T18447 arg1Of inhibits,selectively
R14712 T18448 T18451 arg1Of inhibits,","
R14713 T18450 T18448 arg2Of phosphorylation,inhibits
R14714 T18450 T18449 arg1Of phosphorylation,RPS3
R14715 T18453 T18448 arg3Of retarding,inhibits
R14716 T18453 T18452 arg1Of retarding,thus
R14717 T18453 T18461 arg1Of retarding,","
R14718 T18453 T18462 arg1Of retarding,without
R14719 T18456 T18455 arg1Of translocation,nuclear
R14720 T18456 T18457 arg1Of translocation,and
R14721 T18457 T18453 arg2Of and,retarding
R14722 T18457 T18454 arg1Of and,its
R14723 T18460 T18457 arg2Of function,and
R14724 T18460 T18458 arg1Of function,subsequent
R14725 T18460 T18459 arg1Of function,NF-κB
R14726 T18463 T18462 arg2Of altering,without
R14727 T18466 T18463 arg2Of signaling,altering
R14728 T18466 T18464 arg1Of signaling,other
R14729 T18466 T18465 arg1Of signaling,NF-κB
R14730 T18468 T18469 arg1Of NleH1,did
R14731 T18468 T18472 arg1Of NleH1,phosphorylate
R14732 T18472 T18467 arg2Of phosphorylate,Although
R14733 T18472 T18469 arg2Of phosphorylate,did
R14734 T18472 T18470 arg1Of phosphorylate,not
R14735 T18472 T18471 arg1Of phosphorylate,directly
R14736 T18473 T18472 arg2Of IKKβ,phosphorylate
R14737 T18477 T18475 arg1Of activity,its
R14738 T18477 T18476 arg1Of activity,kinase
R14739 T18477 T18478 arg1Of activity,was
R14740 T18477 T18479 arg2Of activity,required
R14741 T18477 T18481 arg1Of activity,inhibit
R14742 T18479 T18467 arg1Of required,Although
R14743 T18479 T18474 arg1Of required,","
R14744 T18479 T18478 arg2Of required,was
R14745 T18481 T18479 arg3Of inhibit,required
R14746 T18481 T18480 arg1Of inhibit,to
R14747 T18485 T18481 arg2Of phosphorylation,inhibit
R14748 T18485 T18482 arg1Of phosphorylation,IKKβ-mediated
R14749 T18485 T18483 arg1Of phosphorylation,RPS3
R14750 T18485 T18484 arg1Of phosphorylation,S209
R14751 T18488 T18486 arg1Of pathogens,Many
R14752 T18488 T18487 arg1Of pathogens,bacteria
R14753 T18488 T18489 arg1Of pathogens,have
R14754 T18489 T18501 arg1Of have,","
R14755 T18489 T18502 arg1Of have,whereas
R14756 T18490 T18489 arg2Of products,have
R14757 T18490 T18491 arg1Of products,that
R14758 T18490 T18492 arg1Of products,target
R14759 T18494 T18492 arg2Of kinases,target
R14760 T18494 T18493 arg1Of kinases,key
R14761 T18494 T18496 arg1Of kinases,inactivate
R14762 T18496 T18492 arg3Of inactivate,target
R14763 T18496 T18495 arg1Of inactivate,to
R14764 T18496 T18498 arg1Of inactivate,in
R14765 T18497 T18496 arg2Of them,inactivate
R14766 T18500 T18498 arg2Of cells,in
R14767 T18500 T18499 arg1Of cells,host
R14768 T18505 T18503 arg1Of O157,E.
R14769 T18505 T18504 arg1Of O157,coli
R14770 T18507 T18508 arg1Of H7,employed
R14771 T18507 T18511 arg1Of H7,steer
R14772 T18508 T18502 arg2Of employed,whereas
R14773 T18508 T18505 arg1Of employed,O157
R14774 T18508 T18506 arg1Of employed,:
R14775 T18509 T18508 arg2Of NleH1,employed
R14776 T18511 T18508 arg3Of steer,employed
R14777 T18511 T18510 arg1Of steer,to
R14778 T18514 T18511 arg2Of specificity,steer
R14779 T18514 T18512 arg1Of specificity,the
R14780 T18514 T18513 arg1Of specificity,substrate
R14781 T18514 T18515 arg1Of specificity,of
R14782 T18518 T18517 arg1Of specifically,thus
R14783 T18519 T18516 arg1Of fine-tuning,IKKβ
R14784 T18519 T18518 arg1Of fine-tuning,specifically
R14785 T18522 T18515 arg2Of signaling,of
R14786 T18522 T18519 arg1Of signaling,fine-tuning
R14787 T18522 T18520 arg1Of signaling,host
R14788 T18522 T18521 arg1Of signaling,NF-κB
R14789 T18523 T18524 arg1Of This,could
R14790 T18523 T18525 arg1Of This,represent
R14791 T18525 T18524 arg2Of represent,could
R14792 T18528 T18525 arg2Of strategy,represent
R14793 T18528 T18526 arg1Of strategy,a
R14794 T18528 T18527 arg1Of strategy,novel
R14795 T18528 T18529 modOf strategy,to
R14796 T18530 T18529 arg1Of fine-tune,to
R14797 T18533 T18530 arg2Of signaling,fine-tune
R14798 T18533 T18531 arg1Of signaling,host
R14799 T18533 T18532 arg1Of signaling,NF-κB
R14800 T18533 T18534 arg1Of signaling,that
R14801 T18533 T18535 arg1Of signaling,could
R14802 T18533 T18536 arg1Of signaling,be
R14803 T18533 T18537 arg2Of signaling,shared
R14804 T18537 T18535 arg2Of shared,could
R14805 T18537 T18536 arg2Of shared,be
R14806 T18540 T18537 arg1Of pathogens,shared
R14807 T18540 T18538 arg2Of pathogens,by
R14808 T18540 T18539 arg1Of pathogens,other
R14809 T18542 T18541 arg1Of data,These
R14810 T18542 T18543 arg1Of data,provide
R14811 T18545 T18543 arg2Of insights,provide
R14812 T18545 T18544 arg1Of insights,new
R14813 T18545 T18546 arg1Of insights,into
R14814 T18549 T18548 arg1Of understood,poorly
R14815 T18551 T18546 arg2Of mechanism,into
R14816 T18551 T18547 arg1Of mechanism,the
R14817 T18551 T18549 arg1Of mechanism,understood
R14818 T18551 T18550 arg1Of mechanism,action
R14819 T18551 T18552 arg1Of mechanism,for
R14820 T18555 T18552 arg2Of effectors,for
R14821 T18555 T18553 arg1Of effectors,most
R14822 T18555 T18554 arg1Of effectors,T3SS
R14823 T18556 T18557 arg1Of NleH1,attenuates
R14824 T18557 T18570 arg1Of attenuates,","
R14825 T18559 T18557 arg2Of transcription,attenuates
R14826 T18559 T18558 arg1Of transcription,the
R14827 T18559 T18560 arg1Of transcription,of
R14828 T18561 T18563 arg1Of RPS3-dependent,but
R14829 T18563 T18560 arg2Of but,of
R14830 T18563 T18562 arg1Of but,","
R14831 T18563 T18564 arg1Of but,not
R14832 T18569 T18563 arg2Of genes,but
R14833 T18569 T18565 arg1Of genes,all
R14834 T18569 T18566 arg1Of genes,","
R14835 T18569 T18567 arg1Of genes,NF-κB
R14836 T18569 T18568 arg1Of genes,target
R14837 T18572 T18571 arg2Of particular,in
R14838 T18574 T18557 arg3Of genes,attenuates
R14839 T18574 T18571 arg1Of genes,in
R14840 T18574 T18573 arg1Of genes,those
R14841 T18574 T18575 arg2Of genes,associated
R14842 T18575 T18576 arg1Of associated,with
R14843 T18579 T18576 arg2Of responses,with
R14844 T18579 T18577 arg1Of responses,acute
R14845 T18579 T18578 arg1Of responses,proinflammatory
R14846 T18579 T18580 arg1Of responses,","
R14847 T18579 T18581 arg1Of responses,including
R14848 T18582 T18583 arg1Of IL8,and
R14849 T18583 T18581 arg2Of and,including
R14850 T18584 T18583 arg2Of TNF,and
R14851 T18586 T18585 arg2Of contrast,In
R14852 T18588 T18589 arg1Of NleH1,does
R14853 T18588 T18591 arg1Of NleH1,block
R14854 T18591 T18585 arg1Of block,In
R14855 T18591 T18587 arg1Of block,","
R14856 T18591 T18589 arg2Of block,does
R14857 T18591 T18590 arg1Of block,not
R14858 T18595 T18591 arg2Of translocation,block
R14859 T18595 T18592 arg1Of translocation,NF-κB
R14860 T18595 T18593 arg1Of translocation,p65
R14861 T18595 T18594 arg1Of translocation,nuclear
R14862 T18595 T18596 arg1Of translocation,","
R14863 T18595 T18597 arg1Of translocation,which
R14864 T18595 T18598 arg1Of translocation,suggests
R14865 T18601 T18602 arg1Of p65-dependent,but
R14866 T18603 T18602 arg2Of RPS3-independent,but
R14867 T18606 T18600 arg1Of genes,certain
R14868 T18606 T18601 arg1Of genes,p65-dependent
R14869 T18606 T18603 arg1Of genes,RPS3-independent
R14870 T18606 T18604 arg1Of genes,NF-κB
R14871 T18606 T18605 arg1Of genes,target
R14872 T18606 T18607 arg1Of genes,might
R14873 T18606 T18609 arg1Of genes,be
R14874 T18606 T18610 arg1Of genes,beneficial
R14875 T18609 T18598 arg2Of be,suggests
R14876 T18609 T18599 arg1Of be,that
R14877 T18609 T18607 arg2Of be,might
R14878 T18609 T18608 arg1Of be,thus
R14879 T18610 T18609 arg2Of beneficial,be
R14880 T18610 T18611 arg1Of beneficial,for
R14881 T18614 T18611 arg2Of O157,for
R14882 T18614 T18612 arg1Of O157,E.
R14883 T18614 T18613 arg1Of O157,coli
R14884 T18614 T18615 arg1Of O157,:
R14885 T18614 T18617 modOf O157,to
R14886 T18616 T18618 arg2Of H7,replicate
R14887 T18616 T18620 arg2Of H7,disseminate
R14888 T18618 T18619 arg1Of replicate,and
R14889 T18619 T18617 arg1Of and,to
R14890 T18619 T18621 arg1Of and,in
R14891 T18620 T18619 arg2Of disseminate,and
R14892 T18623 T18621 arg2Of host,in
R14893 T18623 T18622 arg1Of host,the
R14894 T18626 T18624 arg2Of inhibiting,By
R14895 T18626 T18625 arg1Of inhibiting,selectively
R14896 T18627 T18628 arg1Of RPS3,and
R14897 T18628 T18626 arg2Of and,inhibiting
R14898 T18632 T18628 arg2Of function,and
R14899 T18632 T18629 arg1Of function,its
R14900 T18632 T18630 arg1Of function,attendant
R14901 T18632 T18631 arg1Of function,NF-κB
R14902 T18632 T18633 arg1Of function,with
R14903 T18634 T18633 arg2Of NleH1,with
R14904 T18637 T18626 arg1Of pathogen,inhibiting
R14905 T18637 T18636 arg1Of pathogen,the
R14906 T18637 T18638 arg1Of pathogen,achieves
R14907 T18638 T18624 arg1Of achieves,By
R14908 T18638 T18635 arg1Of achieves,","
R14909 T18640 T18638 arg2Of ability,achieves
R14910 T18640 T18639 arg1Of ability,the
R14911 T18640 T18641 modOf ability,to
R14912 T18642 T18641 arg1Of increase,to
R14913 T18643 T18644 arg1Of colonization,and
R14914 T18644 T18642 arg2Of and,increase
R14915 T18644 T18647 arg1Of and,limiting
R14916 T18645 T18644 arg2Of diarrhea,and
R14917 T18647 T18646 arg1Of limiting,yet
R14918 T18649 T18647 arg2Of mortality,limiting
R14919 T18649 T18648 arg1Of mortality,the
R14920 T18649 T18650 arg1Of mortality,of
R14921 T18652 T18650 arg2Of host,of
R14922 T18652 T18651 arg1Of host,the
R14923 T18655 T18654 arg1Of paradoxical,seemingly
R14924 T18656 T18653 arg1Of combination,This
R14925 T18656 T18655 arg1Of combination,paradoxical
R14926 T18656 T18657 arg1Of combination,of
R14927 T18656 T18659 arg1Of combination,make
R14928 T18658 T18657 arg2Of effects,of
R14929 T18659 T18661 arg1Of make,when
R14930 T18660 T18659 arg2Of sense,make
R14931 T18662 T18663 arg1Of one,considers
R14932 T18663 T18661 arg2Of considers,when
R14933 T18667 T18665 arg2Of load,increased
R14934 T18667 T18666 arg1Of load,bacterial
R14935 T18667 T18668 arg1Of load,and
R14936 T18668 T18671 arg1Of and,with
R14937 T18668 T18677 arg1Of and,would
R14938 T18668 T18678 arg1Of and,promote
R14939 T18669 T18668 arg2Of diarrhea,and
R14940 T18671 T18670 arg1Of with,together
R14941 T18672 T18671 arg2Of survival,with
R14942 T18672 T18673 arg1Of survival,of
R14943 T18676 T18673 arg2Of host,of
R14944 T18676 T18674 arg1Of host,the
R14945 T18676 T18675 arg1Of host,infected
R14946 T18678 T18663 arg2Of promote,considers
R14947 T18678 T18664 arg1Of promote,that
R14948 T18678 T18677 arg2Of promote,would
R14949 T18678 T18684 arg1Of promote,among
R14950 T18680 T18678 arg2Of spreading,promote
R14951 T18680 T18679 arg1Of spreading,the
R14952 T18680 T18681 arg1Of spreading,of
R14953 T18683 T18681 arg2Of bacteria,of
R14954 T18683 T18682 arg1Of bacteria,the
R14955 T18686 T18684 arg2Of population,among
R14956 T18686 T18685 arg1Of population,a
R14957 T18686 T18687 arg1Of population,of
R14958 T18689 T18687 arg2Of individuals,of
R14959 T18689 T18688 arg1Of individuals,susceptible
R14960 T18691 T18690 arg1Of complex,Such
R14961 T18691 T18692 arg1Of complex,and
R14962 T18692 T18702 arg1Of and,are
R14963 T18692 T18705 arg2Of and,understood
R14964 T18695 T18692 arg2Of effects,and
R14965 T18695 T18693 arg1Of effects,paradoxical
R14966 T18695 T18694 arg1Of effects,pathological
R14967 T18695 T18696 arg1Of effects,that
R14968 T18695 T18697 arg1Of effects,influence
R14969 T18699 T18697 arg2Of spread,influence
R14970 T18699 T18698 arg1Of spread,the
R14971 T18699 T18700 arg1Of spread,of
R14972 T18701 T18700 arg2Of disease,of
R14973 T18705 T18702 arg2Of understood,are
R14974 T18705 T18703 arg1Of understood,often
R14975 T18705 T18704 arg1Of understood,poorly
R14976 T18705 T18706 arg1Of understood,at
R14977 T18709 T18706 arg2Of level,at
R14978 T18709 T18707 arg1Of level,the
R14979 T18709 T18708 arg1Of level,molecular
R14980 T18711 T18710 arg1Of data,Our
R14981 T18711 T18712 arg1Of data,elucidate
R14982 T18713 T18712 arg2Of how,elucidate
R14983 T18714 T18715 arg1Of alterations,in
R14984 T18714 T18719 arg1Of alterations,","
R14985 T18714 T18720 arg2Of alterations,achieved
R14986 T18714 T18732 arg1Of alterations,can
R14987 T18714 T18733 arg1Of alterations,influence
R14988 T18718 T18715 arg2Of function,in
R14989 T18718 T18716 arg1Of function,selective
R14990 T18718 T18717 arg1Of function,NF-κB
R14991 T18720 T18721 arg1Of achieved,by
R14992 T18722 T18725 arg1Of impeding,but
R14993 T18723 T18722 arg2Of RPS3,impeding
R14994 T18725 T18721 arg2Of but,by
R14995 T18725 T18724 arg1Of but,","
R14996 T18725 T18726 arg1Of but,not
R14997 T18727 T18725 arg2Of altering,but
R14998 T18730 T18727 arg2Of translocation,altering
R14999 T18730 T18728 arg1Of translocation,p65
R15000 T18730 T18729 arg1Of translocation,nuclear
R15001 T18733 T18713 arg1Of influence,how
R15002 T18733 T18731 arg1Of influence,","
R15003 T18733 T18732 arg2Of influence,can
R15004 T18735 T18733 arg2Of cytokines,influence
R15005 T18735 T18734 arg1Of cytokines,specific
R15006 T18735 T18736 arg1Of cytokines,that
R15007 T18735 T18737 arg1Of cytokines,affect
R15008 T18739 T18738 arg1Of colonization,bacterial
R15009 T18739 T18740 arg1Of colonization,","
R15010 T18740 T18743 arg1Of ",",and
R15011 T18742 T18740 arg2Of diseases,","
R15012 T18742 T18741 arg1Of diseases,diarrhea
R15013 T18743 T18737 arg2Of and,affect
R15014 T18744 T18743 arg2Of mortality,and
R15015 T18747 T18746 arg2Of be,may
R15016 T18748 T18747 arg2Of fruitful,be
R15017 T18748 T18749 arg1Of fruitful,in
R15018 T18750 T18749 arg2Of attempting,in
R15019 T18752 T18750 arg2Of understand,attempting
R15020 T18752 T18751 arg1Of understand,to
R15021 T18754 T18755 arg1Of infectious,and
R15022 T18756 T18755 arg2Of autoimmune,and
R15023 T18757 T18752 arg2Of diseases,understand
R15024 T18757 T18753 arg1Of diseases,other
R15025 T18757 T18754 arg1Of diseases,infectious
R15026 T18757 T18756 arg1Of diseases,autoimmune
R15027 T18757 T18758 arg1Of diseases,involving
R15028 T18759 T18758 arg2Of NF-κB,involving
R15029 T18761 T18745 arg1Of consider,It
R15030 T18761 T18746 arg1Of consider,may
R15031 T18761 T18747 arg1Of consider,be
R15032 T18761 T18748 arg1Of consider,fruitful
R15033 T18761 T18760 arg1Of consider,to
R15034 T18761 T18769 arg1Of consider,in
R15035 T18763 T18761 arg2Of effects,consider
R15036 T18763 T18762 arg1Of effects,selective
R15037 T18763 T18764 arg1Of effects,of
R15038 T18765 T18764 arg2Of subunits,of
R15039 T18765 T18767 arg1Of subunits,as
R15040 T18767 T18766 arg1Of as,such
R15041 T18768 T18767 arg2Of RPS3,as
R15042 T18770 T18769 arg2Of addition,in
R15043 T18770 T18771 arg1Of addition,to
R15044 T18774 T18771 arg2Of inhibition,to
R15045 T18774 T18772 arg1Of inhibition,global
R15046 T18774 T18773 arg1Of inhibition,NF-κB
R16346 T20522 T20521 arg1Of Constructs,Plasmid
R16347 T20524 T20525 arg1Of Flag-IKKβ,(
R16348 T20524 T20528 arg1Of Flag-IKKβ,","
R16349 T20526 T20525 arg2Of SSEE,(
R16350 T20527 T20525 arg3Of ),(
R16351 T20528 T20534 arg1Of ",",and
R16352 T20529 T20528 arg2Of Flag-IKKβ,","
R16353 T20529 T20530 arg1Of Flag-IKKβ,(
R16354 T20531 T20530 arg2Of SSAA,(
R16355 T20532 T20530 arg3Of ),(
R16356 T20534 T20523 arg1Of and,The
R16357 T20534 T20533 arg1Of and,","
R16358 T20534 T20540 arg1Of and,were
R16359 T20534 T20541 arg2Of and,provided
R16360 T20537 T20536 arg2Of SSAA,(
R16361 T20538 T20536 arg3Of ),(
R16362 T20539 T20534 arg2Of constructs,and
R16363 T20539 T20535 arg1Of constructs,HA-IκBα
R16364 T20539 T20536 arg1Of constructs,(
R16365 T20541 T20540 arg2Of provided,were
R16366 T20541 T20558 arg1Of provided,","
R16367 T20541 T20559 arg1Of provided,respectively
R16368 T20544 T20543 arg1Of Wu,C.
R16369 T20544 T20545 arg1Of Wu,(
R16370 T20544 T20550 arg1Of Wu,and
R16371 T20546 T20545 arg2Of NCI,(
R16372 T20546 T20547 arg1Of NCI,","
R16373 T20546 T20548 arg1Of NCI,Bethesda
R16374 T20549 T20545 arg3Of ),(
R16375 T20550 T20541 arg1Of and,provided
R16376 T20550 T20542 arg2Of and,by
R16377 T20550 T20553 arg1Of and,(
R16378 T20552 T20550 arg2Of Siebenlist,and
R16379 T20552 T20551 arg1Of Siebenlist,U.
R16380 T20554 T20553 arg2Of NIAID,(
R16381 T20554 T20555 arg1Of NIAID,","
R16382 T20554 T20556 arg1Of NIAID,Bethesda
R16383 T20557 T20553 arg3Of ),(
R16384 T20561 T20562 arg1Of HA-IκBα,and
R16385 T20565 T20564 arg2Of K44A,(
R16386 T20566 T20564 arg3Of ),(
R16387 T20567 T20562 arg2Of -Flag,and
R16388 T20567 T20563 arg1Of -Flag,IKKβ
R16389 T20567 T20564 arg1Of -Flag,(
R16390 T20568 T20560 arg1Of plasmids,The
R16391 T20568 T20561 arg1Of plasmids,HA-IκBα
R16392 T20568 T20567 arg1Of plasmids,-Flag
R16393 T20568 T20569 arg1Of plasmids,were
R16394 T20568 T20570 arg2Of plasmids,purchased
R16395 T20570 T20569 arg2Of purchased,were
R16396 T20570 T20571 arg1Of purchased,from
R16397 T20572 T20571 arg2Of Addgene44,from
R16398 T20572 T20573 arg1Of Addgene44,","
R16399 T20574 T20573 arg2Of 45,","
R16400 T20576 T20577 arg1Of Flag-RPS3,","
R16401 T20577 T20579 arg1Of ",",","
R16402 T20578 T20577 arg2Of GST-RPS3,","
R16403 T20579 T20581 arg1Of ",",","
R16404 T20580 T20579 arg2Of HA-RPS3,","
R16405 T20581 T20583 arg1Of ",",","
R16406 T20582 T20581 arg2Of VN-HA,","
R16407 T20583 T20575 arg1Of ",",The
R16408 T20583 T20589 arg1Of ",",","
R16409 T20584 T20586 modOf NleH1-HA,were
R16410 T20585 T20586 arg1Of plasmids,were
R16411 T20585 T20587 arg2Of plasmids,described
R16412 T20587 T20586 arg2Of described,were
R16413 T20588 T20583 arg2Of previously6,","
R16414 T20588 T20584 arg1Of previously6,NleH1-HA
R16415 T20590 T20589 arg2Of 9,","
R16416 T20593 T20591 arg1Of mutants,The
R16417 T20593 T20592 arg1Of mutants,point
R16418 T20593 T20594 arg1Of mutants,of
R16419 T20593 T20596 arg1Of mutants,were
R16420 T20593 T20597 arg2Of mutants,generated
R16421 T20593 T20601 arg1Of mutants,using
R16422 T20595 T20594 arg2Of RPS3,of
R16423 T20597 T20596 arg2Of generated,were
R16424 T20597 T20598 arg1Of generated,by
R16425 T20597 T20601 modOf generated,using
R16426 T20600 T20598 arg2Of mutagenesis,by
R16427 T20600 T20599 arg1Of mutagenesis,site-directed
R16428 T20604 T20603 arg1Of Change,Quick
R16429 T20605 T20601 arg2Of Kit,using
R16430 T20605 T20602 arg1Of Kit,the
R16431 T20605 T20604 arg1Of Kit,Change
R16432 T20605 T20606 arg1Of Kit,(
R16433 T20605 T20609 arg1Of Kit,with
R16434 T20607 T20606 arg2Of Stratagene,(
R16435 T20608 T20606 arg3Of ),(
R16436 T20612 T20613 arg1Of 5′-CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3′,and
R16437 T20613 T20611 arg1Of and,forward
R16438 T20614 T20613 arg2Of reverse,and
R16439 T20615 T20609 arg2Of 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′,with
R16440 T20615 T20610 arg1Of 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′,primers
R16441 T20615 T20612 arg1Of 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′,5′-CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3′
R16442 T20615 T20614 arg1Of 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′,reverse
R16443 T20615 T20616 arg1Of 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′,for
R16444 T20617 T20616 arg2Of S209A,for
R16445 T20619 T20618 arg1Of mutants,All
R16446 T20619 T20620 arg1Of mutants,were
R16447 T20619 T20621 arg2Of mutants,verified
R16448 T20621 T20620 arg2Of verified,were
R16449 T20624 T20621 arg1Of sequencing,verified
R16450 T20624 T20622 arg2Of sequencing,by
R16451 T20624 T20623 arg1Of sequencing,DNA
R16570 T20849 T20848 arg1Of vivo,in
R16571 T20850 T20847 arg1Of Labeling,32P
R16572 T20850 T20849 arg1Of Labeling,vivo
R16573 T20853 T20851 arg1Of cells,HEK
R16574 T20853 T20852 arg1Of cells,293T
R16575 T20853 T20854 arg1Of cells,were
R16576 T20853 T20855 arg2Of cells,labeled
R16577 T20855 T20854 arg2Of labeled,were
R16578 T20855 T20856 arg1Of labeled,with
R16579 T20859 T20856 arg2Of 32P-orthophosphate,with
R16580 T20859 T20857 arg1Of 32P-orthophosphate,2
R16581 T20859 T20858 arg1Of 32P-orthophosphate,mCi/ml
R16582 T20859 T20860 arg1Of 32P-orthophosphate,(
R16583 T20859 T20864 arg1Of 32P-orthophosphate,in
R16584 T20862 T20860 arg2Of Elmer,(
R16585 T20862 T20861 arg1Of Elmer,Perkin
R16586 T20863 T20860 arg3Of ),(
R16587 T20866 T20864 arg2Of medium,in
R16588 T20866 T20865 arg1Of medium,phosphate-free
R16589 T20866 T20867 arg1Of medium,(
R16590 T20866 T20870 arg1Of medium,for
R16591 T20868 T20867 arg2Of Invitrogen,(
R16592 T20869 T20867 arg3Of ),(
R16593 T20872 T20870 arg2Of h,for
R16594 T20872 T20871 arg1Of h,2
R16595 T20873 T20874 arg1Of Cells,were
R16596 T20873 T20876 arg2Of Cells,left
R16597 T20873 T20877 arg1Of Cells,untreated
R16598 T20873 T20879 arg2Of Cells,treated
R16599 T20876 T20874 arg2Of left,were
R16600 T20876 T20875 arg1Of left,then
R16601 T20877 T20878 arg1Of untreated,or
R16602 T20878 T20876 arg3Of or,left
R16603 T20879 T20878 arg2Of treated,or
R16604 T20879 T20880 arg1Of treated,with
R16605 T20881 T20880 arg2Of TNF,with
R16606 T20881 T20882 arg1Of TNF,(
R16607 T20881 T20891 arg1Of TNF,for
R16608 T20884 T20883 arg1Of ng/ml,50
R16609 T20884 T20885 arg1Of ng/ml,","
R16610 T20885 T20882 arg2Of ",",(
R16611 T20889 T20885 arg2Of Systems,","
R16612 T20889 T20886 arg1Of Systems,R
R16613 T20889 T20887 arg1Of Systems,&
R16614 T20889 T20888 arg1Of Systems,D
R16615 T20890 T20882 arg3Of ),(
R16616 T20893 T20891 arg2Of periods,for
R16617 T20893 T20892 arg2Of periods,indicated
R16618 T20895 T20894 arg1Of lysates,Cell
R16619 T20895 T20896 arg1Of lysates,were
R16620 T20895 T20897 arg2Of lysates,prepared
R16621 T20895 T20899 arg2Of lysates,used
R16622 T20897 T20898 arg1Of prepared,and
R16623 T20898 T20896 arg2Of and,were
R16624 T20898 T20900 arg1Of and,for
R16625 T20899 T20898 arg2Of used,and
R16626 T20901 T20900 arg2Of immunoprecipitations,for
R16627 T20901 T20902 arg1Of immunoprecipitations,with
R16628 T20904 T20902 arg2Of antibody,with
R16629 T20904 T20903 arg1Of antibody,RPS3
R16688 T20998 T20995 arg2Of Assay,In
R16689 T20998 T20996 arg1Of Assay,Vitro
R16690 T20998 T20997 arg1Of Assay,Kinase
R16691 T21001 T21002 arg1Of IKKβ,and
R16694 T21004 T21005 arg1Of proteins,were
R16695 T21004 T20999 arg1Of proteins,Kinase-active
R16696 T21004 T21000 arg1Of proteins,recombinant
R16697 T21004 T21001 arg1Of proteins,IKKβ
R16698 T21004 T21006 arg2Of proteins,purchased
R16699 T21006 T21005 arg2Of purchased,were
R16700 T21006 T21007 arg1Of purchased,from
R16701 T21009 T21008 arg1Of Motif,Active
R16702 T21009 T21010 arg1Of Motif,and
R16703 T21010 T21007 arg2Of and,from
R16704 T21010 T21012 arg1Of and,","
R16705 T21010 T21013 arg1Of and,respectively
R16706 T21011 T21010 arg2Of Millipore,and
R16707 T21015 T21014 arg1Of purified,Bacterially
R16708 T21017 T21015 arg1Of S-transferase,purified
R16709 T21017 T21016 arg1Of S-transferase,glutathione
R16710 T21017 T21018 arg1Of S-transferase,(
R16711 T21017 T21021 arg1Of S-transferase,","
R16712 T21019 T21018 arg2Of GST,(
R16713 T21020 T21018 arg3Of ),(
R16714 T21021 T21026 arg1Of ",",","
R16715 T21022 T21021 arg2Of GST-IκBα,","
R16716 T21022 T21023 arg1Of GST-IκBα,(
R16717 T21024 T21023 arg2Of 1-54,(
R16718 T21025 T21023 arg3Of ),(
R16719 T21026 T21029 arg1Of ",",","
R16720 T21028 T21026 arg2Of type,","
R16721 T21028 T21027 arg1Of type,wild
R16722 T21029 T21033 arg1Of ",",or
R16723 T21031 T21029 arg2Of GST-RPS3,","
R16724 T21031 T21030 arg1Of GST-RPS3,mutant
R16725 T21033 T21032 arg1Of or,","
R16726 T21033 T21036 arg1Of or,were
R16727 T21033 T21037 arg2Of or,used
R16728 T21035 T21033 arg2Of proteins,or
R16729 T21035 T21034 arg1Of proteins,RPS3
R16730 T21037 T21036 arg2Of used,were
R16731 T21037 T21038 arg1Of used,as
R16732 T21039 T21038 arg2Of substrates,as
R16733 T21042 T21041 arg1Of vitro,in
R16734 T21044 T21040 arg1Of assay,The
R16735 T21044 T21042 arg1Of assay,vitro
R16736 T21044 T21043 arg1Of assay,kinase
R16737 T21044 T21045 arg1Of assay,was
R16738 T21044 T21046 arg2Of assay,performed
R16739 T21046 T21045 arg2Of performed,was
R16740 T21046 T21047 arg1Of performed,as
R16741 T21049 T21047 arg2Of described29,as
R16742 T21049 T21048 arg1Of described29,previously
R16743 T21052 T21053 arg1Of enzyme,(
R16744 T21052 T21057 arg1Of enzyme,and
R16745 T21055 T21053 arg2Of ng,(
R16746 T21055 T21054 arg1Of ng,100
R16747 T21056 T21053 arg3Of ),(
R16748 T21057 T21063 arg1Of and,were
R16749 T21057 T21064 arg2Of and,co-incubated
R16750 T21058 T21057 arg2Of substrate,and
R16751 T21058 T21059 arg1Of substrate,(
R16752 T21061 T21059 arg2Of μg,(
R16753 T21061 T21060 arg1Of μg,2
R16754 T21062 T21059 arg3Of ),(
R16755 T21064 T21051 arg1Of co-incubated,","
R16756 T21064 T21063 arg2Of co-incubated,were
R16757 T21064 T21065 arg1Of co-incubated,in
R16758 T21068 T21065 arg2Of buffer,in
R16759 T21068 T21066 arg1Of buffer,IKK
R16760 T21068 T21067 arg1Of buffer,reaction
R16761 T21070 T21071 arg1Of 25,mM
R16762 T21072 T21069 arg2Of Tris–HCl,(
R16763 T21072 T21070 arg1Of Tris–HCl,25
R16764 T21072 T21073 arg1Of Tris–HCl,[
R16765 T21074 T21073 arg2Of pH,[
R16766 T21074 T21075 arg1Of pH,8.0
R16767 T21076 T21073 arg3Of ],[
R16768 T21078 T21079 arg1Of 50,mM
R16769 T21080 T21078 arg1Of KCl,50
R16770 T21080 T21081 arg1Of KCl,","
R16771 T21081 T21085 arg1Of ",",","
R16772 T21082 T21083 arg1Of 10,mM
R16773 T21084 T21081 arg2Of MgCl2,","
R16774 T21084 T21082 arg1Of MgCl2,10
R16775 T21085 T21089 arg1Of ",",","
R16776 T21086 T21087 arg1Of 1,mM
R16777 T21088 T21085 arg2Of DTT,","
R16778 T21088 T21086 arg1Of DTT,1
R16779 T21090 T21091 arg1Of 1,mM
R16780 T21092 T21089 arg2Of Na3VO4,","
R16781 T21092 T21090 arg1Of Na3VO4,1
R16782 T21095 T21093 arg2Of mM,","
R16783 T21095 T21094 arg1Of mM,1
R16784 T21101 T21098 arg2Of buffer,or
R16785 T21101 T21099 arg1Of buffer,NleH1
R16786 T21101 T21100 arg1Of buffer,reaction
R16787 T21101 T21102 arg1Of buffer,(
R16788 T21103 T21104 arg1Of 50,mM
R16789 T21105 T21103 arg1Of Tris-HCl,50
R16790 T21105 T21106 arg1Of Tris-HCl,[
R16791 T21105 T21110 arg1Of Tris-HCl,","
R16792 T21107 T21106 arg2Of pH,[
R16793 T21107 T21108 arg1Of pH,7.6
R16794 T21109 T21106 arg3Of ],[
R16795 T21110 T21114 arg1Of ",",","
R16796 T21111 T21112 arg1Of 5,mM
R16797 T21113 T21110 arg2Of MgCl2,","
R16798 T21113 T21111 arg1Of MgCl2,5
R16799 T21114 T21118 arg1Of ",",","
R16800 T21115 T21116 arg1Of 1,mM
R16801 T21117 T21114 arg2Of DTT,","
R16802 T21117 T21115 arg1Of DTT,1
R16803 T21118 T21102 arg2Of ",",(
R16804 T21119 T21120 arg1Of 1,mM
R16805 T21121 T21118 arg2Of ATP,","
R16806 T21121 T21119 arg1Of ATP,1
R16807 T21122 T21102 arg3Of ),(
R16808 T21126 T21123 arg2Of 32P-γ-ATP,with
R16809 T21126 T21124 arg1Of 32P-γ-ATP,0.5
R16810 T21126 T21125 arg1Of 32P-γ-ATP,μCi
R16811 T21126 T21127 arg1Of 32P-γ-ATP,(
R16812 T21129 T21127 arg2Of Healthcare,(
R16813 T21129 T21128 arg1Of Healthcare,GE
R16814 T21130 T21127 arg3Of ),(
R16815 T21131 T21132 arg1Of added,at
R16816 T21131 T21135 arg1Of added,for
R16817 T21134 T21132 arg2Of °C,at
R16818 T21134 T21133 arg1Of °C,37
R16819 T21137 T21135 arg2Of min,for
R16820 T21137 T21136 arg1Of min,30
R16821 T21139 T21138 arg1Of reactions,The
R16822 T21139 T21140 arg1Of reactions,were
R16823 T21139 T21141 arg2Of reactions,resolved
R16824 T21139 T21145 arg2Of reactions,visualized
R16825 T21141 T21142 arg1Of resolved,by
R16826 T21141 T21144 arg1Of resolved,and
R16827 T21143 T21142 arg2Of SDS–PAGE,by
R16828 T21144 T21140 arg2Of and,were
R16829 T21145 T21144 arg2Of visualized,and
R16830 T21147 T21145 arg1Of autoradiography,visualized
R16831 T21147 T21146 arg2Of autoradiography,by
R16993 T21368 T21367 arg1Of Analysis,LC-MS/MS
R16994 T21369 T21370 arg1Of GST,or
R16995 T21370 T21372 arg1Of or,was
R16996 T21370 T21373 arg2Of or,incubated
R16997 T21371 T21370 arg2Of GST-RPS3,or
R16998 T21373 T21372 arg2Of incubated,was
R16999 T21373 T21374 arg1Of incubated,with
R17000 T21373 T21378 arg1Of incubated,as
R17001 T21377 T21374 arg2Of protein,with
R17002 T21377 T21375 arg1Of protein,recombinant
R17003 T21377 T21376 arg1Of protein,IKKβ
R17004 T21379 T21378 arg2Of described,as
R17005 T21379 T21380 arg1Of described,above
R17006 T21379 T21381 arg1Of described,in
R17007 T21384 T21383 arg1Of vitro,in
R17008 T21387 T21381 arg2Of reaction,in
R17009 T21387 T21382 arg1Of reaction,an
R17010 T21387 T21384 arg1Of reaction,vitro
R17011 T21387 T21385 arg1Of reaction,kinase
R17012 T21387 T21386 arg1Of reaction,assay
R17013 T21387 T21388 arg2Of reaction,conducted
R17014 T21388 T21389 arg1Of conducted,without
R17015 T21391 T21389 arg2Of labeling,without
R17016 T21391 T21390 arg1Of labeling,32P-γ-ATP
R17017 T21393 T21392 arg1Of reaction,The
R17018 T21393 T21394 arg1Of reaction,was
R17019 T21393 T21395 arg2Of reaction,separated
R17020 T21395 T21394 arg2Of separated,was
R17021 T21395 T21399 arg1Of separated,and
R17022 T21397 T21395 arg1Of SDS-PAGE,separated
R17023 T21397 T21396 arg2Of SDS-PAGE,by
R17024 T21399 T21398 arg1Of and,","
R17025 T21402 T21400 arg1Of gel,the
R17026 T21402 T21401 arg1Of gel,protein
R17027 T21402 T21403 arg1Of gel,was
R17028 T21402 T21404 arg2Of gel,stained
R17029 T21404 T21399 arg2Of stained,and
R17030 T21404 T21403 arg2Of stained,was
R17031 T21404 T21405 arg1Of stained,with
R17032 T21407 T21405 arg2Of Blue,with
R17033 T21407 T21406 arg1Of Blue,Colloidal
R17034 T21407 T21408 arg1Of Blue,(
R17035 T21409 T21408 arg2Of Invitrogen,(
R17036 T21410 T21408 arg3Of ),(
R17037 T21414 T21411 arg1Of fragments,The
R17038 T21414 T21412 arg1Of fragments,corresponding
R17039 T21414 T21413 arg1Of fragments,protein
R17040 T21414 T21415 arg1Of fragments,were
R17041 T21414 T21416 arg2Of fragments,excised
R17042 T21414 T21418 arg2Of fragments,subjected
R17043 T21416 T21417 arg1Of excised,and
R17044 T21417 T21415 arg2Of and,were
R17045 T21418 T21417 arg2Of subjected,and
R17046 T21418 T21419 arg1Of subjected,to
R17047 T21421 T21420 arg1Of digestion,trypsin
R17048 T21421 T21422 arg1Of digestion,and
R17049 T21422 T21419 arg2Of and,to
R17050 T21422 T21424 arg1Of and,at
R17051 T21423 T21422 arg2Of LC-MS/MS,and
R17052 T21431 T21424 arg2Of Resource,at
R17053 T21431 T21425 arg1Of Resource,the
R17054 T21431 T21426 arg1Of Resource,Yale
R17055 T21431 T21427 arg1Of Resource,Cancer
R17056 T21431 T21428 arg1Of Resource,Center
R17057 T21431 T21429 arg1Of Resource,Mass
R17058 T21431 T21430 arg1Of Resource,Spectrometry
R17059 T21431 T21432 arg1Of Resource,(
R17060 T21434 T21432 arg2Of Haven,(
R17061 T21434 T21433 arg1Of Haven,New
R17062 T21434 T21435 arg1Of Haven,","
R17063 T21436 T21435 arg2Of CT,","
R17064 T21437 T21432 arg3Of ),(
R17139 T21551 T21552 arg1Of RNAi,and
R17140 T21553 T21552 arg2Of Transfection,and
R17141 T21555 T21556 arg1Of siRNA,(
R17142 T21558 T21556 arg2Of sequence,(
R17143 T21558 T21557 arg1Of sequence,sense-strand
R17144 T21559 T21556 arg3Of ),(
R17145 T21560 T21554 arg1Of IKKα,The
R17146 T21560 T21555 arg1Of IKKα,siRNA
R17147 T21560 T21561 arg1Of IKKα,","
R17148 T21560 T21564 arg1Of IKKα,;
R17149 T21563 T21561 arg2Of -3′,","
R17150 T21563 T21562 arg1Of -3′,5′-AUGACAGAGAAUGAUCAUGUUCUGC
R17151 T21565 T21564 arg2Of IKKβ,;
R17152 T21565 T21566 arg1Of IKKβ,","
R17153 T21565 T21569 arg1Of IKKβ,;
R17154 T21565 T21577 arg1Of IKKβ,","
R17155 T21567 T21566 arg2Of 5′-GCAGCAAGGAGAACAGAGGUUAAUA,","
R17156 T21567 T21568 arg1Of 5′-GCAGCAAGGAGAACAGAGGUUAAUA,-3′
R17157 T21570 T21569 arg2Of IκBα,;
R17158 T21570 T21571 arg1Of IκBα,","
R17159 T21573 T21572 arg1Of -3′,5′-GAGCUCCGAGACUUUCGAGGAAAUA
R17160 T21573 T21574 arg1Of -3′,;
R17161 T21574 T21571 arg2Of ;,","
R17162 T21576 T21574 arg2Of UTR,;
R17163 T21576 T21575 arg1Of UTR,RPS3-3′
R17164 T21579 T21577 arg2Of -3′,","
R17165 T21579 T21578 arg1Of -3′,5′-GGAUGUUGCUCUCUAAAGACC
R17166 T21579 T21580 arg1Of -3′,(
R17167 T21581 T21580 arg2Of Invitrogen,(
R17168 T21582 T21580 arg3Of ),(
R17169 T21584 T21583 arg1Of transfection,Transient
R17170 T21584 T21585 arg1Of transfection,of
R17171 T21584 T21590 arg1Of transfection,into
R17172 T21584 T21596 arg1Of transfection,was
R17173 T21586 T21587 arg1Of siRNA,and
R17174 T21588 T21587 arg2Of DNA,and
R17175 T21589 T21585 arg2Of constructs,of
R17176 T21589 T21586 arg1Of constructs,siRNA
R17177 T21589 T21588 arg1Of constructs,DNA
R17178 T21592 T21591 arg1Of cells,Jurkat
R17179 T21592 T21593 arg1Of cells,and
R17180 T21593 T21590 arg2Of and,into
R17181 T21595 T21593 arg2Of cells,and
R17182 T21595 T21594 arg1Of cells,293T
R17183 T21598 T21596 arg2Of previously6,was
R17184 T21598 T21597 arg2Of previously6,described
R17254 T21713 T21712 arg1Of Fractionation,Subcellular
R17255 T21715 T21714 arg1Of fractionation,Subcellular
R17256 T21715 T21716 arg1Of fractionation,was
R17257 T21715 T21717 arg2Of fractionation,performed
R17258 T21717 T21716 arg2Of performed,was
R17259 T21717 T21721 arg1Of performed,as
R17260 T21720 T21717 arg1Of centrifugation,performed
R17261 T21720 T21718 arg2Of centrifugation,by
R17262 T21720 T21719 arg1Of centrifugation,differential
R17263 T21723 T21721 arg2Of described6,as
R17264 T21723 T21722 arg1Of described6,previously
R17265 T21726 T21727 arg1Of cells,were
R17266 T21726 T21728 arg2Of cells,resuspended
R17267 T21728 T21724 arg1Of resuspended,Briefly
R17268 T21728 T21725 arg1Of resuspended,","
R17269 T21728 T21727 arg2Of resuspended,were
R17270 T21728 T21729 arg1Of resuspended,in
R17271 T21728 T21733 arg1Of resuspended,(
R17272 T21728 T21769 arg1Of resuspended,at
R17273 T21728 T21772 arg1Of resuspended,for
R17274 T21732 T21729 arg2Of A,in
R17275 T21732 T21730 arg1Of A,ice-cold
R17276 T21732 T21731 arg1Of A,Buffer
R17277 T21734 T21735 arg1Of 10,mM
R17278 T21737 T21736 arg1Of pH,HEPES
R17279 T21737 T21738 arg1Of pH,7.9
R17280 T21737 T21739 arg1Of pH,","
R17281 T21739 T21743 arg1Of ",",","
R17282 T21740 T21741 arg1Of 10,mM
R17283 T21742 T21739 arg2Of KCl,","
R17284 T21742 T21740 arg1Of KCl,10
R17285 T21743 T21747 arg1Of ",",","
R17286 T21744 T21745 arg1Of 1.5,mM
R17287 T21746 T21743 arg2Of MgCl2,","
R17288 T21746 T21744 arg1Of MgCl2,1.5
R17289 T21747 T21751 arg1Of ",",","
R17290 T21748 T21749 arg1Of 0.1,mM
R17291 T21750 T21747 arg2Of EDTA,","
R17292 T21750 T21748 arg1Of EDTA,0.1
R17293 T21751 T21733 arg2Of ",",(
R17294 T21751 T21734 arg1Of ",",10
R17295 T21752 T21753 arg1Of 0.5,mM
R17296 T21754 T21752 arg1Of DTT,0.5
R17297 T21754 T21755 arg1Of DTT,","
R17298 T21755 T21759 arg1Of ",",","
R17299 T21756 T21757 arg1Of 0.4,%
R17300 T21758 T21755 arg2Of NP-40,","
R17301 T21758 T21756 arg1Of NP-40,0.4
R17302 T21759 T21763 arg1Of ",",","
R17303 T21760 T21761 arg1Of 0.5,mM
R17304 T21762 T21759 arg2Of PMSF,","
R17305 T21762 T21760 arg1Of PMSF,0.5
R17306 T21763 T21751 arg2Of ",",","
R17307 T21767 T21763 arg2Of cocktail,","
R17308 T21767 T21764 arg1Of cocktail,complete
R17309 T21767 T21765 arg1Of cocktail,protease
R17310 T21767 T21766 arg1Of cocktail,inhibitor
R17311 T21768 T21733 arg3Of ),(
R17312 T21771 T21769 arg2Of °C,at
R17313 T21771 T21770 arg1Of °C,4
R17314 T21774 T21772 arg2Of min,for
R17315 T21774 T21773 arg1Of min,5
R17316 T21775 T21776 arg1Of Lysates,were
R17317 T21775 T21777 arg2Of Lysates,centrifuged
R17318 T21777 T21776 arg2Of centrifuged,were
R17319 T21777 T21778 arg1Of centrifuged,at
R17320 T21777 T21789 arg1Of centrifuged,and
R17321 T21780 T21779 arg1Of °C,4
R17322 T21780 T21781 arg1Of °C,","
R17323 T21781 T21778 arg2Of ",",at
R17324 T21784 T21781 arg2Of g,","
R17325 T21784 T21782 arg1Of g,500
R17326 T21784 T21783 arg1Of g,×
R17327 T21784 T21785 arg1Of g,for
R17328 T21787 T21785 arg2Of min,for
R17329 T21787 T21786 arg1Of min,3
R17330 T21789 T21788 arg1Of and,","
R17331 T21790 T21791 arg1Of supernatants,were
R17332 T21790 T21792 arg2Of supernatants,collected
R17333 T21792 T21789 arg2Of collected,and
R17334 T21792 T21791 arg2Of collected,were
R17335 T21792 T21793 arg1Of collected,as
R17336 T21795 T21793 arg2Of fractions,as
R17337 T21795 T21794 arg1Of fractions,cytosolic
R17338 T21796 T21797 arg1Of Pellets,were
R17339 T21796 T21798 arg2Of Pellets,incubated
R17340 T21798 T21797 arg2Of incubated,were
R17341 T21798 T21799 arg1Of incubated,in
R17342 T21801 T21799 arg2Of C,in
R17343 T21801 T21800 arg1Of C,Buffer
R17344 T21801 T21802 arg1Of C,(
R17345 T21801 T21837 arg1Of C,at
R17346 T21806 T21803 arg1Of pH7.9,20
R17347 T21806 T21804 arg1Of pH7.9,mM
R17348 T21806 T21805 arg1Of pH7.9,HEPES
R17349 T21806 T21807 arg1Of pH7.9,","
R17350 T21807 T21811 arg1Of ",",","
R17351 T21808 T21809 arg1Of 420,mM
R17352 T21810 T21807 arg2Of NaCl,","
R17353 T21810 T21808 arg1Of NaCl,420
R17354 T21811 T21815 arg1Of ",",","
R17355 T21812 T21813 arg1Of 1.5,mM
R17356 T21814 T21811 arg2Of MgCl2,","
R17357 T21814 T21812 arg1Of MgCl2,1.5
R17358 T21815 T21819 arg1Of ",",","
R17359 T21816 T21817 arg1Of 25,%
R17360 T21818 T21815 arg2Of glycerol,","
R17361 T21818 T21816 arg1Of glycerol,25
R17362 T21819 T21802 arg2Of ",",(
R17363 T21820 T21821 arg1Of 0.5,mM
R17364 T21822 T21820 arg1Of PMSF,0.5
R17365 T21822 T21823 arg1Of PMSF,","
R17366 T21823 T21827 arg1Of ",",","
R17367 T21824 T21825 arg1Of 0.2,mM
R17368 T21826 T21823 arg2Of EDTA,","
R17369 T21826 T21824 arg1Of EDTA,0.2
R17370 T21827 T21831 arg1Of ",",","
R17371 T21828 T21829 arg1Of 0.5,mM
R17372 T21830 T21827 arg2Of DTT,","
R17373 T21830 T21828 arg1Of DTT,0.5
R17374 T21831 T21819 arg2Of ",",","
R17375 T21835 T21831 arg2Of cocktail,","
R17376 T21835 T21832 arg1Of cocktail,complete
R17377 T21835 T21833 arg1Of cocktail,protease
R17378 T21835 T21834 arg1Of cocktail,inhibitor
R17379 T21836 T21802 arg3Of ),(
R17380 T21839 T21837 arg2Of °C,at
R17381 T21839 T21838 arg1Of °C,4
R17382 T21839 T21840 arg1Of °C,for
R17383 T21842 T21840 arg2Of min,for
R17384 T21842 T21841 arg1Of min,10
R17385 T21843 T21844 arg1Of Supernatants,were
R17386 T21843 T21845 arg2Of Supernatants,collected
R17387 T21845 T21844 arg2Of collected,were
R17388 T21845 T21846 arg1Of collected,as
R17389 T21845 T21849 arg1Of collected,following
R17390 T21845 T21852 arg1Of collected,at
R17391 T21848 T21846 arg2Of fractions,as
R17392 T21848 T21847 arg1Of fractions,nuclear
R17393 T21851 T21849 arg2Of centrifuge,following
R17394 T21851 T21850 arg1Of centrifuge,a
R17395 T21854 T21852 arg2Of °C,at
R17396 T21854 T21853 arg1Of °C,4
R17397 T21854 T21855 arg1Of °C,","
R17398 T21858 T21855 arg2Of g,","
R17399 T21858 T21856 arg1Of g,"13,800"
R17400 T21858 T21857 arg1Of g,×
R17401 T21858 T21859 arg1Of g,for
R17402 T21861 T21859 arg2Of min,for
R17403 T21861 T21860 arg1Of min,10
R17564 T22043 T22041 arg1Of Gene,Luciferase
R17565 T22043 T22042 arg1Of Gene,Reporter
R17566 T22044 T22043 arg1Of Assays,Gene
R17567 T22048 T22045 arg1Of assays,Luciferase
R17568 T22048 T22046 arg1Of assays,reporter
R17569 T22048 T22047 arg1Of assays,gene
R17570 T22048 T22049 arg1Of assays,were
R17571 T22048 T22050 arg2Of assays,performed
R17572 T22050 T22049 arg2Of performed,were
R17573 T22050 T22051 arg1Of performed,as
R17574 T22053 T22051 arg2Of described6,as
R17575 T22053 T22052 arg1Of described6,previously
R17576 T22056 T22057 arg1Of cells,were
R17577 T22056 T22058 arg2Of cells,cotransfected
R17578 T22058 T22054 arg1Of cotransfected,Briefly
R17579 T22058 T22055 arg1Of cotransfected,","
R17580 T22058 T22057 arg2Of cotransfected,were
R17581 T22058 T22059 arg1Of cotransfected,at
R17582 T22061 T22059 arg2Of ratio,at
R17583 T22061 T22060 arg1Of ratio,a
R17584 T22061 T22062 arg1Of ratio,of
R17585 T22061 T22064 arg1Of ratio,:
R17586 T22063 T22062 arg2Of 10,of
R17587 T22065 T22064 arg2Of 1,:
R17588 T22065 T22066 arg1Of 1,with
R17589 T22071 T22066 arg2Of constructs,with
R17590 T22071 T22067 arg1Of constructs,various
R17591 T22071 T22068 arg1Of constructs,promoter-driven
R17592 T22071 T22069 arg1Of constructs,firefly
R17593 T22071 T22070 arg1Of constructs,luciferase
R17594 T22071 T22072 arg1Of constructs,to
R17595 T22077 T22072 arg2Of plasmid,to
R17596 T22077 T22073 arg1Of plasmid,the
R17597 T22077 T22074 arg1Of plasmid,Renilla
R17598 T22077 T22075 arg1Of plasmid,luciferase
R17599 T22077 T22076 arg1Of plasmid,pTKRL
R17600 T22077 T22078 arg1Of plasmid,","
R17601 T22077 T22080 arg1Of plasmid,with
R17602 T22080 T22079 arg1Of with,together
R17603 T22082 T22080 arg2Of plasmids,with
R17604 T22082 T22081 arg2Of plasmids,indicated
R17605 T22083 T22084 arg1Of Cells,were
R17606 T22083 T22085 arg2Of Cells,cultured
R17607 T22083 T22091 arg2Of Cells,stimulated
R17608 T22085 T22086 arg1Of cultured,for
R17609 T22085 T22089 arg1Of cultured,and
R17610 T22088 T22086 arg2Of days,for
R17611 T22088 T22087 arg1Of days,1–2
R17612 T22089 T22084 arg2Of and,were
R17613 T22091 T22089 arg2Of stimulated,and
R17614 T22091 T22090 arg1Of stimulated,then
R17615 T22091 T22092 arg1Of stimulated,in
R17616 T22093 T22092 arg2Of triplicate,in
R17617 T22093 T22094 arg1Of triplicate,before
R17618 T22095 T22094 arg2Of harvest,before
R17619 T22096 T22097 arg1Of Lysates,were
R17620 T22096 T22098 arg2Of Lysates,analyzed
R17621 T22098 T22097 arg2Of analyzed,were
R17622 T22099 T22098 arg3Of using,analyzed
R17623 T22102 T22099 arg2Of Kit,using
R17624 T22102 T22100 arg1Of Kit,the
R17625 T22102 T22101 arg1Of Kit,Dual-Luciferase
R17626 T22102 T22103 arg1Of Kit,(
R17627 T22104 T22103 arg2Of Promega,(
R17628 T22105 T22103 arg3Of ),(
R17699 T22218 T22217 arg1Of Immunoprecipitation,Chromatin
R17700 T22218 T22219 arg1Of Immunoprecipitation,(
R17701 T22220 T22219 arg2Of ChIP,(
R17702 T22221 T22219 arg3Of ),(
R17703 T22223 T22222 arg1Of assays,ChIP
R17704 T22223 T22224 arg1Of assays,was
R17705 T22223 T22225 arg2Of assays,performed
R17706 T22225 T22224 arg2Of performed,was
R17707 T22225 T22226 arg1Of performed,as
R17708 T22228 T22226 arg2Of described6,as
R17709 T22228 T22227 arg1Of described6,previously
R17710 T22230 T22231 arg2Of primers,used
R17711 T22230 T22249 arg1Of primers,as
R17712 T22233 T22231 arg3Of amplify,used
R17713 T22233 T22232 arg1Of amplify,to
R17714 T22236 T22233 arg2Of region,amplify
R17715 T22236 T22234 arg1Of region,the
R17716 T22236 T22235 arg1Of region,promoter
R17717 T22236 T22237 arg1Of region,adjacent
R17718 T22237 T22238 arg1Of adjacent,to
R17719 T22241 T22238 arg2Of sites,to
R17720 T22241 T22239 arg1Of sites,the
R17721 T22241 T22240 arg1Of sites,κB
R17722 T22241 T22242 arg1Of sites,of
R17723 T22243 T22244 arg1Of IL8,and
R17724 T22244 T22242 arg2Of and,of
R17725 T22245 T22244 arg2Of NFKBIA,and
R17726 T22249 T22229 arg1Of as,The
R17727 T22249 T22246 arg1Of as,","
R17728 T22249 T22247 arg1Of as,as
R17729 T22249 T22248 arg1Of as,well
R17730 T22249 T22251 arg1Of as,have
R17731 T22249 T22252 arg1Of as,been
R17732 T22250 T22249 arg2Of ACTB,as
R17733 T22252 T22251 arg2Of been,have
R17734 T22253 T22252 arg2Of described6,been
R17778 T22329 T22328 arg1Of Microscopy,Immunofluorescence
R17779 T22331 T22330 arg1Of microscopy,Confocal
R17780 T22331 T22332 arg1Of microscopy,was
R17781 T22331 T22333 arg2Of microscopy,performed
R17782 T22333 T22332 arg2Of performed,was
R17783 T22333 T22334 arg1Of performed,as
R17784 T22336 T22334 arg2Of described6,as
R17785 T22336 T22335 arg1Of described6,previously
R17786 T22339 T22340 arg1Of cells,were
R17787 T22339 T22341 arg2Of cells,fixed
R17788 T22341 T22340 arg2Of fixed,were
R17789 T22341 T22342 arg1Of fixed,with
R17790 T22341 T22348 arg1Of fixed,and
R17791 T22343 T22344 arg1Of 4,%
R17792 T22345 T22342 arg2Of paraformaldehyde,with
R17793 T22345 T22343 arg1Of paraformaldehyde,4
R17794 T22345 T22346 arg1Of paraformaldehyde,in
R17795 T22347 T22346 arg2Of PBS,in
R17796 T22348 T22337 arg1Of and,Briefly
R17797 T22348 T22338 arg1Of and,","
R17798 T22350 T22351 arg1Of Cellspin,mounted
R17799 T22351 T22348 arg2Of mounted,and
R17800 T22351 T22349 arg1Of mounted,then
R17801 T22351 T22352 arg1Of mounted,onto
R17802 T22353 T22352 arg2Of slides,onto
R17803 T22356 T22354 arg1Of cells,The
R17804 T22356 T22355 arg2Of cells,fixed
R17805 T22356 T22357 arg1Of cells,were
R17806 T22356 T22359 arg2Of cells,permeabilized
R17807 T22356 T22368 arg2Of cells,stained
R17808 T22359 T22360 arg1Of permeabilized,with
R17809 T22359 T22367 arg1Of permeabilized,and
R17810 T22364 T22360 arg2Of X-100,with
R17811 T22364 T22361 arg1Of X-100,0.05
R17812 T22364 T22362 arg1Of X-100,%
R17813 T22364 T22363 arg1Of X-100,Triton
R17814 T22364 T22365 arg1Of X-100,in
R17815 T22366 T22365 arg2Of PBS,in
R17816 T22367 T22357 arg2Of and,were
R17817 T22367 T22358 arg1Of and,then
R17818 T22368 T22367 arg2Of stained,and
R17819 T22368 T22369 arg1Of stained,with
R17820 T22373 T22369 arg2Of antibodies,with
R17821 T22373 T22370 arg1Of antibodies,FITC-conjugated
R17822 T22373 T22371 arg1Of antibodies,rabbit
R17823 T22373 T22372 arg1Of antibodies,anti-RPS3
R17824 T22373 T22374 arg1Of antibodies,(
R17825 T22376 T22374 arg2Of Biotech,(
R17826 T22376 T22375 arg1Of Biotech,Primm
R17827 T22377 T22374 arg3Of ),(
R17828 T22379 T22378 arg1Of or,","
R17829 T22384 T22379 arg2Of antibodies,or
R17830 T22384 T22380 arg1Of antibodies,AlexaFluor
R17831 T22384 T22381 arg1Of antibodies,594-conjugated
R17832 T22384 T22382 arg1Of antibodies,rat
R17833 T22384 T22383 arg1Of antibodies,anti-Flag
R17834 T22384 T22385 arg1Of antibodies,(
R17835 T22385 T22388 arg1Of (,for
R17836 T22386 T22385 arg2Of BD,(
R17837 T22387 T22385 arg3Of ),(
R17838 T22390 T22388 arg2Of min,for
R17839 T22390 T22389 arg1Of min,40
R17840 T22391 T22392 arg1Of together,with
R17841 T22394 T22392 arg2Of μg/ml,with
R17842 T22394 T22393 arg1Of μg/ml,1
R17843 T22394 T22395 arg1Of μg/ml,of
R17844 T22394 T22401 arg1Of μg/ml,for
R17845 T22394 T22404 arg1Of μg/ml,at
R17846 T22396 T22395 arg2Of Hoechst,of
R17847 T22396 T22397 arg1Of Hoechst,33342
R17848 T22396 T22398 arg1Of Hoechst,(
R17849 T22399 T22398 arg2Of Sigma,(
R17850 T22400 T22398 arg3Of ),(
R17851 T22403 T22401 arg2Of min,for
R17852 T22403 T22402 arg1Of min,5
R17853 T22406 T22404 arg2Of °C.,at
R17854 T22406 T22405 arg1Of °C.,25
R17855 T22408 T22407 arg1Of slides,The
R17856 T22408 T22409 arg1Of slides,were
R17857 T22408 T22411 arg2Of slides,rinsed
R17858 T22411 T22409 arg2Of rinsed,were
R17859 T22411 T22410 arg1Of rinsed,then
R17860 T22411 T22412 arg1Of rinsed,with
R17861 T22411 T22416 arg1Of rinsed,and
R17862 T22415 T22412 arg2Of times,with
R17863 T22415 T22413 arg1Of times,PBS
R17864 T22415 T22414 arg1Of times,three
R17865 T22417 T22418 arg1Of cover,mounted
R17866 T22418 T22416 arg2Of mounted,and
R17867 T22418 T22419 arg1Of mounted,for
R17868 T22421 T22419 arg2Of microscopy,for
R17869 T22421 T22420 arg1Of microscopy,fluorescence
R17971 T22550 T22551 arg1Of Immunoprecipitation,and
R17972 T22552 T22551 arg2Of immunoblot,and
R17973 T22554 T22553 arg1Of cells,The
R17974 T22554 T22555 arg1Of cells,were
R17975 T22554 T22556 arg2Of cells,harvested
R17976 T22554 T22558 arg2Of cells,lysed
R17977 T22556 T22557 arg1Of harvested,and
R17978 T22557 T22555 arg2Of and,were
R17979 T22558 T22557 arg2Of lysed,and
R17980 T22558 T22559 arg1Of lysed,on
R17981 T22558 T22561 arg1Of lysed,by
R17982 T22560 T22559 arg2Of ice,on
R17983 T22563 T22561 arg2Of ml,by
R17984 T22563 T22562 arg1Of ml,0.4
R17985 T22563 T22564 arg1Of ml,of
R17986 T22568 T22564 arg2Of buffer,of
R17987 T22568 T22565 arg1Of buffer,the
R17988 T22568 T22566 arg2Of buffer,modified
R17989 T22568 T22567 arg1Of buffer,RIPA
R17990 T22568 T22569 arg1Of buffer,(
R17991 T22568 T22606 arg2Of buffer,supplemented
R17992 T22570 T22571 arg1Of 50,mM
R17993 T22572 T22570 arg1Of Tris-HCl,50
R17994 T22572 T22573 arg1Of Tris-HCl,[
R17995 T22572 T22577 arg1Of Tris-HCl,","
R17996 T22574 T22573 arg2Of pH,[
R17997 T22574 T22575 arg1Of pH,7.4
R17998 T22576 T22573 arg3Of ],[
R17999 T22577 T22569 arg2Of ",",(
R18000 T22577 T22581 arg1Of ",",","
R18001 T22578 T22579 arg1Of 1,%
R18002 T22580 T22577 arg2Of NP-40,","
R18003 T22580 T22578 arg1Of NP-40,1
R18004 T22582 T22583 arg1Of 0.25,%
R18005 T22582 T22584 arg1Of 0.25,Na-deoxycholate
R18006 T22582 T22585 arg1Of 0.25,","
R18007 T22586 T22585 arg2Of 150,","
R18008 T22586 T22587 arg1Of 150,mM
R18009 T22588 T22582 arg1Of NaCl,0.25
R18010 T22588 T22586 arg1Of NaCl,150
R18011 T22588 T22589 arg1Of NaCl,","
R18012 T22589 T22593 arg1Of ",",","
R18013 T22590 T22591 arg1Of 1,mM
R18014 T22592 T22589 arg2Of EDTA,","
R18015 T22592 T22590 arg1Of EDTA,1
R18016 T22593 T22597 arg1Of ",",","
R18017 T22594 T22595 arg1Of 1,mM
R18018 T22596 T22593 arg2Of PMSF,","
R18019 T22596 T22594 arg1Of PMSF,1
R18020 T22597 T22601 arg1Of ",",","
R18021 T22598 T22599 arg1Of 1,mM
R18022 T22600 T22597 arg2Of Na3VO4,","
R18023 T22600 T22598 arg1Of Na3VO4,1
R18024 T22601 T22581 arg2Of ",",","
R18025 T22602 T22603 arg1Of 1,mM
R18026 T22604 T22601 arg2Of NaF,","
R18027 T22604 T22602 arg1Of NaF,1
R18028 T22605 T22569 arg3Of ),(
R18029 T22606 T22607 arg1Of supplemented,with
R18030 T22606 T22628 arg1Of supplemented,for
R18031 T22612 T22608 arg1Of cocktail,1
R18032 T22612 T22609 arg1Of cocktail,×
R18033 T22612 T22610 arg1Of cocktail,protease
R18034 T22612 T22611 arg1Of cocktail,inhibitor
R18035 T22612 T22613 arg1Of cocktail,(
R18036 T22612 T22616 arg1Of cocktail,and
R18037 T22614 T22613 arg2Of Roche,(
R18038 T22615 T22613 arg3Of ),(
R18039 T22616 T22607 arg2Of and,with
R18040 T22617 T22618 arg1Of 1,×
R18041 T22619 T22618 arg2Of phosphatase,×
R18042 T22622 T22616 arg2Of set,and
R18043 T22622 T22617 arg1Of set,1
R18044 T22622 T22619 arg1Of set,phosphatase
R18045 T22622 T22620 arg1Of set,inhibitor
R18046 T22622 T22621 arg1Of set,cocktail
R18047 T22622 T22623 arg1Of set,I
R18048 T22622 T22624 arg1Of set,(
R18049 T22626 T22624 arg2Of Biosciences,(
R18050 T22626 T22625 arg1Of Biosciences,EMD
R18051 T22627 T22624 arg3Of ),(
R18052 T22630 T22628 arg2Of min,for
R18053 T22630 T22629 arg1Of min,30
R18054 T22632 T22631 arg1Of lysates,The
R18055 T22632 T22633 arg1Of lysates,were
R18056 T22632 T22634 arg2Of lysates,centrifuged
R18057 T22634 T22633 arg2Of centrifuged,were
R18058 T22634 T22635 arg1Of centrifuged,at
R18059 T22638 T22635 arg2Of g,at
R18060 T22638 T22636 arg1Of g,"10,000"
R18061 T22638 T22637 arg1Of g,×
R18062 T22638 T22639 arg1Of g,at
R18063 T22638 T22642 arg1Of g,for
R18064 T22641 T22639 arg2Of °C,at
R18065 T22641 T22640 arg1Of °C,4
R18066 T22644 T22642 arg2Of min,for
R18067 T22644 T22643 arg1Of min,10
R18068 T22644 T22646 arg1Of min,remove
R18069 T22646 T22642 arg3Of remove,for
R18070 T22646 T22645 arg1Of remove,to
R18071 T22648 T22646 arg2Of material,remove
R18072 T22648 T22647 arg1Of material,insoluble
R18073 T22650 T22649 arg2Of normalizing,After
R18074 T22652 T22650 arg2Of concentrations,normalizing
R18075 T22652 T22651 arg1Of concentrations,protein
R18076 T22654 T22650 arg1Of lysates,normalizing
R18077 T22654 T22655 arg1Of lysates,were
R18078 T22654 T22656 arg2Of lysates,subjected
R18079 T22654 T22660 arg1Of lysates,adding
R18080 T22654 T22676 arg2Of lysates,rotated
R18081 T22656 T22657 arg1Of subjected,to
R18082 T22656 T22659 arg1Of subjected,by
R18083 T22656 T22675 arg1Of subjected,and
R18084 T22658 T22657 arg2Of immunoprecipitation,to
R18085 T22660 T22659 arg2Of adding,by
R18086 T22660 T22671 arg1Of adding,(
R18087 T22664 T22661 arg1Of antibody,10
R18088 T22664 T22662 arg1Of antibody,mg/ml
R18089 T22664 T22663 arg1Of antibody,appropriate
R18090 T22664 T22665 arg1Of antibody,plus
R18091 T22665 T22660 arg2Of plus,adding
R18092 T22667 T22665 arg2Of ml,plus
R18093 T22667 T22666 arg1Of ml,30
R18094 T22667 T22668 arg1Of ml,of
R18095 T22670 T22668 arg2Of G-agarose,of
R18096 T22670 T22669 arg1Of G-agarose,protein
R18097 T22672 T22671 arg2Of Roche,(
R18098 T22673 T22671 arg3Of ),(
R18099 T22675 T22649 arg1Of and,After
R18100 T22675 T22653 arg1Of and,","
R18101 T22675 T22655 arg2Of and,were
R18102 T22675 T22674 arg1Of and,","
R18103 T22676 T22675 arg2Of rotated,and
R18104 T22676 T22677 arg1Of rotated,for
R18105 T22676 T22691 arg1Of rotated,times
R18106 T22680 T22678 arg1Of 2,at
R18107 T22680 T22679 arg1Of 2,least
R18108 T22681 T22677 arg2Of h,for
R18109 T22681 T22680 arg1Of h,2
R18110 T22681 T22682 arg1Of h,at
R18111 T22683 T22682 arg2Of 4°C.,at
R18112 T22683 T22686 modOf 4°C.,were
R18113 T22685 T22684 arg1Of precipitates,The
R18114 T22685 T22686 arg1Of precipitates,were
R18115 T22685 T22687 arg2Of precipitates,washed
R18116 T22687 T22686 arg2Of washed,were
R18117 T22690 T22688 arg1Of five,at
R18118 T22690 T22689 arg1Of five,least
R18119 T22691 T22690 arg1Of times,five
R18120 T22691 T22692 arg1Of times,with
R18121 T22695 T22692 arg2Of buffer,with
R18122 T22695 T22693 arg1Of buffer,cold
R18123 T22695 T22694 arg1Of buffer,lysis
R18124 T22695 T22696 arg2Of buffer,followed
R18125 T22696 T22697 arg1Of followed,by
R18126 T22696 T22701 arg1Of followed,under
R18127 T22698 T22697 arg2Of separation,by
R18128 T22700 T22696 arg1Of SDS-PAGE,followed
R18129 T22700 T22699 arg2Of SDS-PAGE,by
R18130 T22705 T22701 arg2Of conditions,under
R18131 T22705 T22702 arg2Of conditions,reduced
R18132 T22705 T22703 arg1Of conditions,and
R18133 T22705 T22704 arg1Of conditions,denaturing
R18134 T22707 T22706 arg1Of membranes,Nitrocellulose
R18135 T22707 T22708 arg1Of membranes,were
R18136 T22707 T22709 arg2Of membranes,blocked
R18137 T22709 T22708 arg2Of blocked,were
R18138 T22709 T22710 arg1Of blocked,in
R18139 T22711 T22712 arg1Of 5,%
R18140 T22714 T22710 arg2Of milk,in
R18141 T22714 T22711 arg1Of milk,5
R18142 T22714 T22713 arg1Of milk,nonfat
R18143 T22714 T22715 arg1Of milk,in
R18144 T22716 T22717 arg1Of 0.1,%
R18145 T22719 T22715 arg2Of 20,in
R18146 T22719 T22716 arg1Of 20,0.1
R18147 T22719 T22718 arg1Of 20,PBS-Tween
R18148 T22719 T22720 arg1Of 20,(
R18149 T22719 T22723 arg1Of 20,","
R18150 T22719 T22724 arg2Of 20,probed
R18151 T22721 T22720 arg2Of PBS-T,(
R18152 T22722 T22720 arg3Of ),(
R18153 T22724 T22725 arg1Of probed,with
R18154 T22727 T22725 arg2Of antibodies,with
R18155 T22727 T22726 arg1Of antibodies,specific
R18156 T22727 T22728 arg1Of antibodies,as
R18157 T22730 T22728 arg2Of previously6,as
R18158 T22730 T22729 arg2Of previously6,described
R18159 T22732 T22731 arg2Of immunoblotting,For
R18160 T22732 T22733 arg1Of immunoblotting,of
R18161 T22735 T22733 arg2Of proteins,of
R18162 T22735 T22734 arg2Of proteins,phosphorylated
R18163 T22737 T22738 arg1Of gels,were
R18164 T22737 T22739 arg2Of gels,transferred
R18165 T22737 T22751 arg1Of gels,dried
R18166 T22739 T22738 arg2Of transferred,were
R18167 T22739 T22740 arg1Of transferred,to
R18168 T22739 T22750 arg1Of transferred,and
R18169 T22744 T22740 arg2Of membranes,to
R18170 T22744 T22741 arg1Of membranes,methanol-treated
R18171 T22744 T22742 arg1Of membranes,polyvinylidene
R18172 T22744 T22743 arg1Of membranes,chloride
R18173 T22744 T22745 arg1Of membranes,","
R18174 T22744 T22746 arg2Of membranes,retreated
R18175 T22746 T22747 arg1Of retreated,with
R18176 T22748 T22747 arg2Of methanol,with
R18177 T22750 T22731 arg1Of and,For
R18178 T22750 T22736 arg1Of and,","
R18179 T22750 T22749 arg1Of and,","
R18180 T22751 T22750 arg2Of dried,and
R18181 T22751 T22752 arg1Of dried,for
R18182 T22754 T22752 arg2Of min,for
R18183 T22754 T22753 arg1Of min,30
R18184 T22755 T22756 arg1Of Blots,were
R18185 T22755 T22757 arg2Of Blots,blocked
R18186 T22755 T22776 arg2Of Blots,probed
R18187 T22757 T22758 arg1Of blocked,in
R18188 T22757 T22764 arg1Of blocked,in
R18189 T22757 T22770 arg1Of blocked,20
R18190 T22757 T22775 arg1Of blocked,and
R18191 T22759 T22760 arg1Of 5,%
R18192 T22763 T22758 arg2Of albumin,in
R18193 T22763 T22759 arg1Of albumin,5
R18194 T22763 T22761 arg1Of albumin,bovine
R18195 T22763 T22762 arg1Of albumin,serum
R18196 T22766 T22764 arg2Of %,in
R18197 T22766 T22765 arg1Of %,0.1
R18198 T22766 T22768 arg2Of %,buffered
R18199 T22767 T22768 arg1Of Tris,buffered
R18200 T22770 T22769 arg1Of 20,saline-Tween
R18201 T22770 T22771 arg1Of 20,(
R18202 T22772 T22771 arg2Of TBS-T,(
R18203 T22773 T22771 arg3Of ),(
R18204 T22775 T22756 arg2Of and,were
R18205 T22775 T22774 arg1Of and,","
R18206 T22776 T22775 arg2Of probed,and
R18207 T22776 T22777 arg1Of probed,with
R18208 T22776 T22780 arg1Of probed,as
R18209 T22779 T22777 arg2Of antibodies,with
R18210 T22779 T22778 arg1Of antibodies,specific
R18211 T22782 T22780 arg2Of previously46,as
R18212 T22782 T22781 arg2Of previously46,described
R18213 T22783 T22784 arg1Of Bands,were
R18214 T22783 T22785 arg2Of Bands,imaged
R18215 T22785 T22784 arg2Of imaged,were
R18216 T22785 T22794 arg1Of imaged,according
R18217 T22790 T22785 arg1Of system,imaged
R18218 T22790 T22786 arg2Of system,by
R18219 T22790 T22787 arg1Of system,the
R18220 T22790 T22788 arg1Of system,Super
R18221 T22790 T22789 arg1Of system,Signaling
R18222 T22790 T22791 arg1Of system,(
R18223 T22792 T22791 arg2Of Pierce,(
R18224 T22793 T22791 arg3Of ),(
R18225 T22795 T22794 arg2Of to,according
R18226 T22797 T22796 arg1Of manufacturer,the
R18227 T22797 T22798 arg2Of manufacturer,'s
R18228 T22799 T22795 arg2Of instructions,to
R18229 T22799 T22798 arg1Of instructions,'s
R18491 T23107 T23106 arg1Of amount,The
R18492 T23107 T23108 arg1Of amount,of
R18493 T23107 T23110 arg1Of amount,present
R18494 T23107 T23118 arg1Of amount,was
R18495 T23107 T23119 arg2Of amount,measured
R18496 T23109 T23108 arg2Of IL-8,of
R18497 T23110 T23111 arg1Of present,in
R18498 T23112 T23111 arg2Of supernatants,in
R18499 T23112 T23113 arg2Of supernatants,collected
R18500 T23113 T23114 arg1Of collected,from
R18501 T23117 T23114 arg2Of culture,from
R18502 T23117 T23115 arg1Of culture,Jurkat
R18503 T23117 T23116 arg1Of culture,cell
R18504 T23119 T23118 arg2Of measured,was
R18505 T23120 T23119 arg3Of using,measured
R18506 T23120 T23130 arg1Of using,according
R18507 T23126 T23120 arg2Of kit,using
R18508 T23126 T23121 arg1Of kit,a
R18509 T23126 T23122 arg1Of kit,Human
R18510 T23126 T23123 arg1Of kit,Interleukin-8
R18511 T23126 T23124 arg1Of kit,ELISA
R18512 T23126 T23125 arg1Of kit,Ready-SET-Go
R18513 T23126 T23127 arg1Of kit,(
R18514 T23128 T23127 arg2Of eBioscience,(
R18515 T23129 T23127 arg3Of ),(
R18516 T23131 T23130 arg2Of to,according
R18517 T23133 T23132 arg1Of manufacturer,the
R18518 T23133 T23134 arg2Of manufacturer,'s
R18519 T23135 T23131 arg2Of instructions,to
R18520 T23135 T23134 arg1Of instructions,'s
R18553 T23196 T23195 arg1Of Infections,Cell
R18554 T23198 T23197 arg1Of cells,HeLa
R18555 T23198 T23199 arg1Of cells,were
R18556 T23198 T23200 arg2Of cells,infected
R18557 T23200 T23199 arg2Of infected,were
R18558 T23200 T23201 arg1Of infected,with
R18559 T23200 T23205 arg1Of infected,:
R18560 T23204 T23201 arg2Of O157,with
R18561 T23204 T23202 arg1Of O157,E.
R18562 T23204 T23203 arg1Of O157,coli
R18563 T23205 T23211 arg1Of :,as
R18564 T23206 T23207 arg1Of H7,or
R18565 T23207 T23205 arg2Of or,:
R18566 T23210 T23207 arg2Of strains,or
R18567 T23210 T23208 arg1Of strains,C.
R18568 T23210 T23209 arg1Of strains,rodentium
R18569 T23213 T23211 arg2Of previously9,as
R18570 T23213 T23212 arg2Of previously9,described
R18591 T23245 T23244 arg1Of piglets,Gnotobiotic
R18592 T23245 T23246 arg1Of piglets,were
R18593 T23245 T23247 arg2Of piglets,infected
R18594 T23247 T23246 arg2Of infected,were
R18595 T23247 T23248 arg1Of infected,with
R18596 T23247 T23255 arg1Of infected,as
R18597 T23251 T23249 arg1Of O157,E.
R18598 T23251 T23250 arg1Of O157,coli
R18599 T23251 T23252 arg1Of O157,:
R18600 T23252 T23248 arg2Of :,with
R18601 T23254 T23252 arg2Of strains,:
R18602 T23254 T23253 arg1Of strains,H7
R18603 T23257 T23255 arg2Of previously9,as
R18604 T23257 T23256 arg2Of previously9,described
R18605 T23260 T23258 arg1Of specimens,Spiral
R18606 T23260 T23259 arg1Of specimens,colon
R18607 T23260 T23261 arg1Of specimens,were
R18608 T23260 T23262 arg2Of specimens,collected
R18609 T23260 T23266 arg2Of specimens,embedded
R18610 T23262 T23263 arg1Of collected,at
R18611 T23262 T23265 arg1Of collected,and
R18612 T23264 T23263 arg2Of necropsy,at
R18613 T23265 T23261 arg2Of and,were
R18614 T23266 T23265 arg2Of embedded,and
R18615 T23266 T23267 arg1Of embedded,in
R18616 T23268 T23267 arg2Of paraffin,in
R18617 T23270 T23269 arg1Of sectioning,Paraffin
R18618 T23270 T23271 arg1Of sectioning,and
R18619 T23271 T23274 arg1Of and,using
R18620 T23271 T23277 arg1Of and,were
R18621 T23271 T23278 arg2Of and,performed
R18622 T23273 T23271 arg2Of staining,and
R18623 T23273 T23272 arg1Of staining,immunohistochemical
R18624 T23276 T23274 arg2Of antibody,using
R18625 T23276 T23275 arg1Of antibody,phospho-RPS3
R18626 T23278 T23277 arg2Of performed,were
R18627 T23281 T23278 arg1Of Inc,performed
R18628 T23281 T23279 arg2Of Inc,by
R18629 T23281 T23280 arg1Of Inc,Histoserv
R4098 T5170 T5169 arg1Of import,nuclear
R4099 T5170 T5171 arg1Of import,of
R16692 T21003 T21002 arg2Of IKKα,and
R16693 T21004 T21003 arg1Of proteins,IKKα

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T9792 14850-14860 Antecedent denotes attraction
T15644 23400-23402 Anaphor denotes it
T15645 23316-23320 Antecedent denotes RPS3
T7631 11710-11725 Anaphor denotes phosphorylation
T18775 24360-24363 Anaphor denotes its
T18776 24287-24291 Antecedent denotes RPS3
T18777 24865-24885 Anaphor denotes this phosphorylation
T18778 24835-24849 Antecedent denotes phosphorylated
T18779 26061-26064 Anaphor denotes its
T18780 26024-26028 Antecedent denotes RPS3
T7632 11689-11704 Antecedent denotes phosphorylation
T5565 6887-6890 Anaphor denotes its
T5566 6825-6829 Antecedent denotes RPS3
T12385 17601-17604 Anaphor denotes its
T12386 17576-17580 Antecedent denotes RPS3
T15640 20398-20400 Anaphor denotes do
T15641 20316-20323 Antecedent denotes reduced
T15642 21727-21746 Anaphor denotes inhibitory activity
T15643 21665-21670 Antecedent denotes block
T9789 14754-14756 Anaphor denotes it
T9790 14704-14709 Antecedent denotes S209A
T9791 15114-15129 Anaphor denotes the recruitment
R6124 T7631 T7632 boundBy phosphorylation,phosphorylation
R15047 T18775 T18776 boundBy its,RPS3
R15048 T18777 T18778 boundBy this phosphorylation,phosphorylated
R15049 T18779 T18780 boundBy its,RPS3
R10013 T12385 T12386 boundBy its,RPS3
R4495 T5565 T5566 boundBy its,RPS3
R12627 T15640 T15641 boundBy do,reduced
R12628 T15642 T15643 boundBy inhibitory activity,block
R12629 T15644 T15645 boundBy it,RPS3
R7911 T9789 T9790 boundBy it,S209A
R7912 T9791 T9792 boundBy the recruitment,attraction

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T284 234-238 WDT denotes that
T285 239-246 VBZ denotes directs
T286 247-255 JJ denotes specific
T287 256-260 NN denotes gene
T288 261-274 NN denotes transcription
T289 274-275 . denotes .
T290 276-283 RB denotes However
T291 283-284 , denotes ,
T292 285-287 PRP denotes it
T293 288-290 VBZ denotes is
T294 291-298 JJ denotes unknown
T295 299-302 WRB denotes how
T296 303-307 JJ denotes RPS3
T297 308-315 JJ denotes nuclear
T298 316-329 NN denotes translocation
T299 330-332 VBZ denotes is
T300 333-342 VBN denotes regulated
T301 342-343 . denotes .
T302 344-348 RB denotes Here
T303 349-351 PRP denotes we
T304 352-358 VBP denotes report
T305 359-363 IN denotes that
T306 364-368 NNP denotes IKKβ
T307 369-384 NN denotes phosphorylation
T308 385-387 IN denotes of
T309 388-394 NN denotes serine
T310 395-398 CD denotes 209
T311 399-400 -LRB- denotes (
T312 400-404 CD denotes S209
T313 404-405 -RRB- denotes )
T314 406-409 VBD denotes was
T315 410-417 JJ denotes crucial
T316 418-421 IN denotes for
T317 422-426 JJ denotes RPS3
T318 427-434 JJ denotes nuclear
T319 435-447 NN denotes localization
T320 448-450 IN denotes in
T321 451-459 NN denotes response
T322 460-462 TO denotes to
T323 463-473 VBG denotes activating
T324 474-481 NNS denotes stimuli
T325 481-482 . denotes .
T326 483-491 RB denotes Moreover
T327 491-492 , denotes ,
T328 493-496 DT denotes the
T329 497-506 NN denotes foodborne
T330 507-515 NN denotes pathogen
T331 516-527 NNP denotes Escherichia
T332 528-532 NNS denotes coli
T333 533-537 NNP denotes O157
T334 537-538 : denotes :
T335 538-540 NNP denotes H7
T336 541-550 NN denotes virulence
T337 551-558 NN denotes protein
T338 559-564 NNP denotes NleH1
T339 565-577 RB denotes specifically
T340 578-587 VBD denotes inhibited
T341 588-592 NNP denotes RPS3
T342 593-597 NNP denotes S209
T343 598-613 NN denotes phosphorylation
T344 614-617 CC denotes and
T345 618-625 VBD denotes blocked
T346 626-630 CD denotes RPS3
T347 631-639 NN denotes function
T348 639-640 , denotes ,
T349 641-648 RB denotes thereby
T350 649-658 VBG denotes promoting
T351 659-668 JJ denotes bacterial
T352 669-681 NN denotes colonization
T353 682-685 CC denotes and
T354 686-694 NN denotes diarrhea
T355 695-698 CC denotes but
T356 699-709 VBG denotes decreasing
T357 710-719 NN denotes mortality
T358 720-722 IN denotes in
T359 723-724 DT denotes a
T360 725-736 JJ denotes gnotobiotic
T361 737-743 NN denotes piglet
T362 744-753 NN denotes infection
T363 754-759 NN denotes model
T364 759-760 . denotes .
T365 761-765 RB denotes Thus
T366 765-766 , denotes ,
T367 767-770 DT denotes the
T368 771-785 JJ denotes IKKβ-dependent
T369 786-798 NN denotes modification
T370 799-801 IN denotes of
T371 802-803 DT denotes a
T372 804-812 JJ denotes specific
T373 813-818 JJ denotes amino
T374 819-823 NN denotes acid
T375 824-826 IN denotes in
T376 827-831 CD denotes RPS3
T377 832-840 VBZ denotes promotes
T378 841-849 JJ denotes specific
T379 850-855 NN denotes NF-κB
T380 856-865 NNS denotes functions
T381 866-870 WDT denotes that
T382 871-879 VBP denotes underlie
T383 880-883 DT denotes the
T384 884-893 JJ denotes molecular
T385 894-906 JJ denotes pathogenetic
T386 907-917 NNS denotes mechanisms
T387 918-920 IN denotes of
T388 921-923 NNP denotes E.
T389 924-928 NNS denotes coli
T390 929-933 NNP denotes O157
T391 933-934 : denotes :
T392 934-936 NNP denotes H7
T393 936-937 . denotes .
T1161 939-946 NNP denotes Nuclear
T1162 947-959 NNP denotes Factor-kappa
T1163 960-961 NNP denotes B
T1164 962-963 -LRB- denotes (
T1165 963-968 NNP denotes NF-κB
T1166 968-969 -RRB- denotes )
T1167 970-979 VBZ denotes regulates
T1168 980-987 JJ denotes crucial
T1169 988-996 JJ denotes cellular
T1170 997-1006 NNS denotes functions
T1171 1007-1010 CC denotes and
T1172 1011-1018 JJ denotes diverse
T1173 1019-1026 NNS denotes stimuli
T1174 1027-1035 VBP denotes activate
T1175 1036-1040 DT denotes this
T1176 1041-1052 JJ denotes pleiotropic
T1177 1053-1066 NN denotes transcription
T1178 1067-1073 NN denotes factor
T1179 1073-1074 , denotes ,
T1180 1075-1080 WDT denotes which
T1181 1081-1083 IN denotes in
T1182 1084-1088 NN denotes turn
T1183 1089-1098 VBZ denotes regulates
T1184 1099-1100 DT denotes a
T1185 1101-1105 JJ denotes vast
T1186 1106-1111 NN denotes array
T1187 1112-1114 IN denotes of
T1188 1115-1122 JJ denotes genetic
T1189 1123-1133 JJ denotes targets1-3
T1190 1133-1134 . denotes .
T1191 1135-1138 DT denotes The
T1192 1139-1149 JJ denotes best-known
T1193 1150-1159 JJ denotes mammalian
T1194 1160-1165 NN denotes NF-κB
T1195 1166-1174 NNS denotes subunits
T1196 1175-1178 VBP denotes are
T1197 1179-1182 NNP denotes Rel
T1198 1183-1191 NNS denotes proteins
T1199 1191-1192 , denotes ,
T1200 1193-1202 VBG denotes including
T1201 1203-1207 NNP denotes RelA
T1202 1208-1209 -LRB- denotes (
T1203 1209-1212 NNS denotes p65
T1204 1212-1213 -RRB- denotes )
T1205 1213-1214 , denotes ,
T1206 1215-1219 NNP denotes RelB
T1207 1219-1220 , denotes ,
T1208 1221-1226 NNP denotes c-Rel
T1209 1226-1227 , denotes ,
T1210 1228-1231 CD denotes p50
T1211 1231-1232 , denotes ,
T1212 1233-1236 CC denotes and
T1213 1237-1240 CD denotes p52
T1214 1241-1242 -LRB- denotes (
T1215 1242-1246 NNS denotes refs
T1216 1246-1247 . denotes .
T1217 1248-1252 CD denotes 4, 5
T1218 1252-1253 -RRB- denotes )
T1219 1253-1254 . denotes .
T1220 1255-1262 RB denotes However
T1221 1262-1263 , denotes ,
T1222 1264-1266 PRP denotes we
T1223 1267-1275 RB denotes recently
T1224 1276-1288 VBD denotes demonstrated
T1225 1289-1293 IN denotes that
T1226 1294-1303 JJ denotes ribosomal
T1227 1304-1311 NN denotes protein
T1228 1312-1314 NNP denotes S3
T1229 1315-1316 -LRB- denotes (
T1230 1316-1320 NNP denotes RPS3
T1231 1320-1321 -RRB- denotes )
T1232 1322-1324 VBZ denotes is
T1233 1325-1326 DT denotes a
T1234 1327-1330 JJ denotes key
T1235 1331-1338 JJ denotes non-Rel
T1236 1339-1346 NN denotes subunit
T1237 1347-1349 IN denotes of
T1238 1350-1357 JJ denotes certain
T1239 1358-1364 JJ denotes native
T1240 1365-1370 NN denotes NF-κB
T1241 1371-1381 NNS denotes complexes6
T1242 1381-1382 . denotes .
T1243 1383-1387 CD denotes RPS3
T1244 1388-1390 VBZ denotes is
T1245 1391-1398 VBN denotes defined
T1246 1399-1401 IN denotes as
T1247 1402-1403 DT denotes a
T1248 1405-1414 NN denotes specifier
T1249 1416-1423 NN denotes subunit
T1250 1424-1426 IN denotes of
T1251 1427-1432 NNP denotes NF-κB
T1252 1432-1433 , denotes ,
T1253 1434-1441 IN denotes because
T1254 1442-1444 PRP denotes it
T1255 1445-1456 VBZ denotes facilitates
T1256 1457-1461 JJ denotes high
T1257 1462-1470 NN denotes affinity
T1258 1471-1474 NNP denotes DNA
T1259 1475-1482 JJ denotes binding
T1260 1483-1487 RB denotes thus
T1261 1488-1499 VBG denotes determining
T1262 1500-1503 DT denotes the
T1263 1504-1514 JJ denotes regulatory
T1264 1515-1526 NN denotes specificity
T1265 1527-1529 IN denotes of
T1266 1530-1535 NN denotes NF-κB
T1267 1536-1539 IN denotes for
T1268 1540-1548 VBN denotes selected
T1269 1549-1555 NN denotes target
T1270 1556-1562 NNS denotes genes7
T1271 1562-1563 . denotes .
T1272 1564-1568 CD denotes RPS3
T1273 1569-1579 NN denotes regulation
T1274 1580-1582 IN denotes of
T1275 1583-1588 JJ denotes NF-κB
T1276 1589-1596 NNS denotes governs
T1277 1597-1600 JJ denotes key
T1278 1601-1614 JJ denotes physiological
T1279 1615-1624 NNS denotes processes
T1280 1624-1625 , denotes ,
T1281 1626-1635 VBG denotes including
T1282 1636-1650 NN denotes immunoglobulin
T1283 1651-1652 NN denotes κ
T1284 1653-1658 NN denotes light
T1285 1659-1664 NN denotes chain
T1286 1665-1669 NN denotes gene
T1287 1670-1680 NN denotes expression
T1288 1681-1684 CC denotes and
T1289 1685-1693 NN denotes receptor
T1290 1694-1701 NN denotes editing
T1291 1702-1704 IN denotes in
T1292 1705-1706 NNP denotes B
T1293 1707-1713 CD denotes cells6
T1294 1713-1716 CD denotes , 8
T1295 1716-1717 , denotes ,
T1296 1718-1726 NN denotes cytokine
T1297 1727-1737 NN denotes production
T1298 1738-1740 IN denotes in
T1299 1741-1742 NNP denotes T
T1300 1743-1749 CD denotes cells6
T1301 1749-1750 , denotes ,
T1302 1751-1754 CC denotes and
T1303 1755-1757 IN denotes in
T1304 1758-1762 NN denotes host
T1305 1763-1770 NN denotes defense
T1306 1771-1778 IN denotes against
T1307 1779-1808 NNP denotes enterohemorrhagic Escherichia
T1308 1809-1813 NNS denotes coli
T1309 1814-1815 -LRB- denotes (
T1310 1815-1819 NNP denotes EHEC
T1311 1819-1820 -RRB- denotes )
T1312 1820-1821 CD denotes 9
T1313 1821-1822 . denotes .
T1314 1823-1825 IN denotes In
T1315 1826-1836 JJ denotes particular
T1316 1836-1837 , denotes ,
T1317 1838-1843 NNP denotes the E
T1318 1843-1844 . denotes .
T1319 1845-1854 NNP denotes coli O157
T1320 1854-1855 : denotes :
T1321 1855-1857 NNP denotes H7
T1322 1858-1862 NN denotes type
T1323 1863-1866 NNP denotes III
T1324 1867-1876 NN denotes secretion
T1325 1877-1883 NN denotes system
T1326 1884-1885 -LRB- denotes (
T1327 1885-1889 CD denotes T3SS
T1328 1889-1890 -RRB- denotes )
T1329 1891-1899 NN denotes effector
T1330 1900-1907 NN denotes protein
T1331 1908-1913 NNP denotes NleH1
T1332 1914-1925 RB denotes selectively
T1333 1926-1932 NNS denotes blocks
T1334 1933-1938 JJ denotes NF-κB
T1335 1939-1945 NN denotes target
T1336 1946-1950 NN denotes gene
T1337 1951-1964 NN denotes transcription
T1338 1965-1967 IN denotes by
T1339 1968-1979 VBG denotes attenuating
T1340 1980-1984 JJ denotes RPS3
T1341 1985-1992 JJ denotes nuclear
T1342 1993-2006 NN denotes translocation
T1343 2006-2007 , denotes ,
T1344 2008-2015 IN denotes without
T1345 2016-2025 VBG denotes affecting
T1346 2026-2029 CD denotes p65
T1347 2030-2043 CD denotes localization9
T1348 2043-2044 . denotes .
T1349 2045-2056 RB denotes Nonetheless
T1350 2056-2057 , denotes ,
T1351 2058-2061 WRB denotes how
T1352 2062-2070 JJ denotes specific
T1353 2071-2076 NN denotes NF-κB
T1354 2077-2087 VBG denotes activating
T1355 2088-2095 NNS denotes signals
T1356 2096-2102 VB denotes induce
T1357 2103-2107 NNP denotes RPS3
T1358 2108-2115 JJ denotes nuclear
T1359 2116-2129 NN denotes translocation
T1360 2130-2132 VBZ denotes is
T1361 2133-2157 JJ denotes unknown. Extra-ribosomal
T1362 2158-2167 NNS denotes functions
T1363 2168-2172 VBP denotes have
T1364 2173-2177 VBN denotes been
T1365 2178-2186 VBN denotes ascribed
T1366 2187-2189 TO denotes to
T1367 2190-2199 JJ denotes ribosomal
T1368 2200-2210 NNS denotes proteins10
T1369 2210-2211 . denotes .
T1370 2212-2219 IN denotes Besides
T1371 2220-2227 JJ denotes binding
T1372 2228-2231 NNP denotes RNA
T1373 2232-2238 IN denotes within
T1374 2239-2242 DT denotes the
T1375 2243-2246 NNP denotes 40S
T1376 2247-2256 JJ denotes ribosomal
T1377 2257-2264 NN denotes subunit
T1378 2264-2265 , denotes ,
T1379 2266-2270 JJ denotes RPS3
T1380 2271-2283 VBZ denotes participates
T1381 2284-2286 IN denotes in
T1382 2287-2301 CD denotes transcription6
T1383 2301-2302 , denotes ,
T1384 2303-2306 NNP denotes DNA
T1385 2307-2315 CD denotes repair11
T1386 2315-2319 CD denotes , 12
T1387 2319-2320 , denotes ,
T1388 2321-2324 CC denotes and
T1389 2325-2336 CD denotes apoptosis13
T1390 2336-2337 . denotes .
T1391 2338-2345 IN denotes Whether
T1392 2346-2348 CC denotes or
T1393 2349-2352 RB denotes not
T1394 2353-2357 NNP denotes RPS3
T1395 2358-2360 VBZ denotes is
T1396 2361-2375 VBN denotes phosphorylated
T1397 2376-2379 VBD denotes had
T1398 2380-2384 VBN denotes been
T1399 2385-2403 JJ denotes controversial14-18
T1400 2403-2404 . denotes .
T1401 2405-2410 IN denotes Since
T1402 2411-2417 NN denotes kinase
T1403 2418-2426 NNS denotes cascades
T1404 2427-2431 VBP denotes play
T1405 2432-2433 DT denotes a
T1406 2434-2442 JJ denotes critical
T1407 2443-2447 NN denotes role
T1408 2448-2450 IN denotes in
T1409 2451-2456 JJ denotes NF-κB
T1410 2457-2467 NN denotes regulation
T1411 2467-2468 , denotes ,
T1412 2469-2471 PRP denotes we
T1413 2472-2478 VBD denotes tested
T1414 2479-2486 IN denotes whether
T1415 2487-2491 NNP denotes RPS3
T1416 2492-2494 VBZ denotes is
T1417 2495-2509 VBN denotes phosphorylated
T1418 2510-2512 IN denotes in
T1419 2513-2516 DT denotes the
T1420 2517-2524 NN denotes context
T1421 2525-2527 IN denotes of
T1422 2528-2533 JJ denotes NF-κB
T1423 2534-2544 NN denotes activation
T1424 2545-2548 CC denotes and
T1425 2549-2555 VBD denotes sought
T1426 2556-2558 TO denotes to
T1427 2559-2567 VB denotes identify
T1428 2568-2571 DT denotes the
T1429 2572-2583 JJ denotes responsible
T1430 2584-2592 NN denotes kinase19
T1431 2592-2593 . denotes .
T1432 2594-2606 RB denotes Additionally
T1433 2606-2607 , denotes ,
T1434 2608-2610 PRP denotes we
T1435 2611-2616 VBD denotes aimed
T1436 2617-2619 TO denotes to
T1437 2620-2626 VB denotes define
T1438 2627-2628 DT denotes a
T1439 2629-2639 JJ denotes regulatory
T1440 2640-2644 NN denotes role
T1441 2645-2648 IN denotes for
T1442 2649-2652 DT denotes the
T1443 2653-2663 JJ denotes C-terminal
T1444 2664-2668 NN denotes tail
T1445 2669-2671 IN denotes of
T1446 2672-2676 CD denotes RPS3
T1447 2677-2682 WP$ denotes whose
T1448 2683-2691 NN denotes function
T1449 2692-2695 VBD denotes was
T1450 2696-2709 JJ denotes unknown. Here
T1451 2710-2712 PRP denotes we
T1452 2713-2717 VBP denotes show
T1453 2718-2722 IN denotes that
T1454 2723-2726 DT denotes the
T1455 2727-2736 NNP denotes Inhibitor
T1456 2737-2739 IN denotes of
T1457 2740-2742 NNP denotes κB
T1458 2743-2744 -LRB- denotes (
T1459 2744-2747 NNP denotes IκB
T1460 2747-2748 -RRB- denotes )
T1461 2749-2755 NN denotes kinase
T1462 2756-2760 NN denotes beta
T1463 2761-2762 -LRB- denotes (
T1464 2762-2766 NNP denotes IKKβ
T1465 2766-2767 -RRB- denotes )
T1466 2768-2782 VBD denotes phosphorylated
T1467 2783-2787 CD denotes RPS3
T1468 2788-2790 IN denotes at
T1469 2791-2797 NN denotes serine
T1470 2798-2801 CD denotes 209
T1471 2802-2803 -LRB- denotes (
T1472 2803-2807 CD denotes S209
T1473 2807-2808 -RRB- denotes )
T1474 2808-2809 . denotes .
T1475 2810-2814 CD denotes RPS3
T1476 2815-2819 CD denotes S209
T1477 2820-2835 NN denotes phosphorylation
T1478 2836-2844 VBD denotes enhanced
T1479 2845-2848 PRP$ denotes its
T1480 2849-2860 NN denotes association
T1481 2861-2865 IN denotes with
T1482 2866-2876 JJ denotes importin-α
T1483 2876-2877 , denotes ,
T1484 2878-2887 VBG denotes mediating
T1485 2888-2892 CD denotes RPS3
T1486 2893-2898 NN denotes entry
T1487 2899-2903 IN denotes into
T1488 2904-2907 DT denotes the
T1489 2908-2919 NN denotes karyopherin
T1490 2920-2927 NN denotes pathway
T1491 2928-2931 IN denotes for
T1492 2932-2939 JJ denotes nuclear
T1493 2940-2953 NN denotes translocation
T1494 2953-2954 . denotes .
T1495 2955-2966 RB denotes Furthermore
T1496 2966-2967 , denotes ,
T1497 2968-2973 NNP denotes the E
T1498 2973-2974 . denotes .
T1499 2975-2985 CD denotes coli NleH1
T1500 2986-2994 NN denotes effector
T1501 2995-3007 RB denotes specifically
T1502 3008-3017 VBD denotes inhibited
T1503 3018-3022 NNP denotes RPS3
T1504 3023-3027 NNP denotes S209
T1505 3028-3037 VBG denotes revealing
T1506 3038-3043 NNP denotes how E
T1507 3043-3044 . denotes .
T1508 3045-3054 NNP denotes coli O157
T1509 3054-3055 : denotes :
T1510 3055-3057 NNP denotes H7
T1511 3058-3066 VBZ denotes inhibits
T1512 3067-3071 DT denotes this
T1513 3072-3081 JJ denotes important
T1514 3082-3088 NN denotes innate
T1515 3089-3095 JJ denotes immune
T1516 3096-3104 NN denotes response
T1517 3105-3114 NN denotes mechanism
T1518 3114-3115 . denotes .
T2170 3126-3130 CD denotes RPS3
T2171 3131-3146 NN denotes phosphorylation
T2172 3147-3149 IN denotes in
T2173 3150-3158 NN denotes response
T2174 3159-3161 TO denotes to
T2175 3162-3167 JJ denotes NF-κB
T2176 3168-3178 NN denotes activation
T2177 3179-3181 TO denotes To
T2178 3182-3186 NN denotes test
T2179 3187-3194 IN denotes whether
T2180 3195-3199 NNP denotes RPS3
T2181 3200-3202 VBZ denotes is
T2182 3203-3217 VBN denotes phosphorylated
T2183 3218-3224 IN denotes during
T2184 3225-3230 NNP denotes NF-κB
T2185 3231-3241 NN denotes activation
T2186 3241-3242 , denotes ,
T2187 3243-3245 PRP denotes we
T2188 3246-3255 VBD denotes performed
T2189 3256-3268 JJ denotes 32P-labeling
T2190 3269-3280 NNS denotes experiments
T2191 3281-3283 IN denotes in
T2192 3284-3289 NN denotes tumor
T2193 3290-3298 NN denotes necrosis
T2194 3299-3305 NN denotes factor
T2195 3306-3307 -LRB- denotes (
T2196 3307-3310 NNP denotes TNF
T2197 3310-3311 -RRB- denotes )
T2198 3311-3312 : denotes -
T2199 3312-3322 VBN denotes stimulated
T2200 3323-3326 NNP denotes HEK
T2201 3327-3331 CD denotes 293T
T2202 3332-3337 NNS denotes cells
T2203 3337-3338 . denotes .
T2204 3339-3344 IN denotes While
T2205 3345-3349 NNP denotes RPS3
T2206 3350-3353 VBD denotes was
T2207 3354-3362 RB denotes scarcely
T2208 3363-3377 VBN denotes phosphorylated
T2209 3378-3380 IN denotes in
T2210 3381-3393 JJ denotes unstimulated
T2211 3394-3399 NNS denotes cells
T2212 3399-3400 , denotes ,
T2213 3401-3403 PRP denotes we
T2214 3404-3412 VBD denotes observed
T2215 3413-3414 DT denotes a
T2216 3415-3421 JJ denotes marked
T2217 3422-3430 NN denotes increase
T2218 3431-3433 IN denotes in
T2219 3434-3451 NN denotes 32P-incorporation
T2220 3452-3457 IN denotes after
T2221 3458-3461 NNP denotes TNF
T2222 3462-3473 NN denotes stimulation
T2223 3474-3481 IN denotes despite
T2224 3482-3484 DT denotes no
T2225 3485-3493 NN denotes increase
T2226 3494-3496 IN denotes in
T2227 3497-3501 CD denotes RPS3
T2228 3502-3509 NN denotes protein
T2229 3510-3511 -LRB- denotes (
T2230 3511-3515 NNP denotes Fig.
T2231 3516-3518 CD denotes 1a
T2232 3518-3519 -RRB- denotes )
T2233 3519-3520 . denotes .
T2234 3521-3523 TO denotes To
T2235 3524-3533 VB denotes determine
T2236 3534-3539 WDT denotes which
T2237 3540-3544 NNP denotes RPS3
T2238 3545-3553 NNS denotes residues
T2239 3554-3558 VBD denotes were
T2240 3559-3573 VBN denotes phosphorylated
T2241 3573-3574 , denotes ,
T2242 3575-3577 PRP denotes we
T2243 3578-3596 VBD denotes immunoprecipitated
T2244 3597-3601 CD denotes RPS3
T2245 3602-3606 IN denotes from
T2246 3607-3613 CC denotes either
T2247 3614-3621 VBG denotes resting
T2248 3622-3624 CC denotes or
T2249 3625-3635 VBN denotes stimulated
T2250 3636-3641 NNS denotes cells
T2251 3642-3645 CC denotes and
T2252 3646-3655 VBN denotes performed
T2253 3656-3670 VBG denotes immunoblotting
T2254 3671-3675 IN denotes with
T2255 3676-3700 JJ denotes phosphorylation-specific
T2256 3701-3711 NNS denotes antibodies
T2257 3711-3712 . denotes .
T2258 3713-3717 DT denotes Both
T2259 3718-3721 NNP denotes TNF
T2260 3722-3725 CC denotes and
T2261 3726-3733 JJ denotes phorbol
T2262 3734-3743 NN denotes myristate
T2263 3744-3761 NN denotes acetate/ionomycin
T2264 3762-3763 -LRB- denotes (
T2265 3763-3768 NNP denotes PMA+I
T2266 3768-3769 -RRB- denotes )
T2267 3770-3780 VBD denotes stimulated
T2268 3781-3786 JJ denotes rapid
T2269 3787-3802 NN denotes phosphorylation
T2270 3803-3806 CC denotes and
T2271 3807-3817 NN denotes degradaion
T2272 3818-3820 IN denotes of
T2273 3821-3825 NNP denotes IκBα
T2274 3826-3832 IN denotes within
T2275 3833-3834 CD denotes 5
T2276 3835-3838 NN denotes min
T2277 3839-3844 WDT denotes which
T2278 3845-3848 VBD denotes was
T2279 3849-3860 VBN denotes accompanied
T2280 3861-3863 IN denotes by
T2281 3864-3868 CD denotes RPS3
T2282 3869-3884 NN denotes phosphorylation
T2283 3885-3887 IN denotes on
T2284 3888-3894 NN denotes serine
T2285 3895-3903 NNS denotes residues
T2286 3904-3905 -LRB- denotes (
T2287 3905-3909 NNP denotes Fig.
T2288 3910-3912 CD denotes 1b
T2289 3913-3916 CC denotes and
T2290 3917-3921 NNS denotes data
T2291 3922-3925 RB denotes not
T2292 3926-3931 VBN denotes shown
T2293 3931-3932 -RRB- denotes )
T2294 3932-3933 , denotes ,
T2295 3934-3941 JJ denotes similar
T2296 3942-3944 TO denotes to
T2297 3945-3948 DT denotes the
T2298 3949-3951 IN denotes in
T2299 3952-3956 NN denotes vivo
T2300 3957-3965 VBG denotes labeling
T2301 3965-3966 . denotes .
T2302 3967-3969 PRP denotes We
T2303 3970-3973 VBD denotes did
T2304 3974-3977 RB denotes not
T2305 3978-3984 VB denotes detect
T2306 3985-3993 NN denotes tyrosine
T2307 3993-3994 : denotes -
T2308 3995-3997 CC denotes or
T2309 3998-4023 NN denotes threonine-phosphorylation
T2310 4024-4026 IN denotes of
T2311 4027-4031 NNP denotes RPS3
T2312 4032-4033 -LRB- denotes (
T2313 4033-4037 NNP denotes Fig.
T2314 4038-4040 CD denotes 1b
T2315 4040-4041 -RRB- denotes )
T2316 4041-4042 . denotes .
T2826 4044-4048 CD denotes RPS3
T2827 4049-4052 CC denotes and
T2828 4053-4057 NNP denotes IKKβ
T2829 4058-4069 NN denotes interaction
T2830 4070-4073 DT denotes The
T2831 4074-4084 NN denotes activation
T2832 4085-4087 IN denotes of
T2833 4088-4091 DT denotes the
T2834 4092-4101 NN denotes inhibitor
T2835 4102-4104 IN denotes of
T2836 4105-4107 NN denotes κB
T2837 4108-4114 NN denotes kinase
T2838 4115-4116 -LRB- denotes (
T2839 4116-4119 NNP denotes IKK
T2840 4119-4120 -RRB- denotes )
T2841 4120-4121 , denotes ,
T2842 4122-4132 VBG denotes consisting
T2843 4133-4135 IN denotes of
T2844 4136-4137 DT denotes a
T2845 4138-4148 JJ denotes regulatory
T2846 4149-4156 NN denotes subunit
T2847 4157-4161 NNP denotes IKKγ
T2848 4162-4165 CC denotes and
T2849 4166-4169 CD denotes two
T2850 4170-4179 JJ denotes catalytic
T2851 4180-4188 NNS denotes subunits
T2852 4188-4189 , denotes ,
T2853 4190-4194 NNP denotes IKKα
T2854 4195-4198 CC denotes and
T2855 4199-4203 NNP denotes IKKβ
T2856 4203-4204 , denotes ,
T2857 4205-4207 VBZ denotes is
T2858 4208-4216 JJ denotes critical
T2859 4217-4220 IN denotes for
T2860 4221-4224 DT denotes the
T2861 4225-4240 NN denotes phosphorylation
T2862 4241-4244 CC denotes and
T2863 4245-4253 VB denotes dispatch
T2864 4254-4256 IN denotes of
T2865 4257-4260 DT denotes the
T2866 4261-4271 JJ denotes inhibitory
T2867 4272-4276 NNS denotes IκBs
T2868 4277-4280 CC denotes and
T2869 4281-4284 DT denotes the
T2870 4285-4295 NN denotes liberation
T2871 4296-4298 IN denotes of
T2872 4299-4309 NN denotes NF-κB20-22
T2873 4309-4310 . denotes .
T2874 4311-4316 VBN denotes Given
T2875 4317-4321 IN denotes that
T2876 4322-4326 NNP denotes RPS3
T2877 4327-4330 MD denotes can
T2878 4331-4333 VB denotes be
T2879 4334-4339 VBN denotes found
T2880 4340-4342 IN denotes in
T2881 4343-4346 DT denotes the
T2882 4347-4358 JJ denotes cytoplasmic
T2883 4359-4371 NN denotes p65-p50-IκBα
T2884 4372-4382 NN denotes inhibitory
T2885 4383-4390 NN denotes complex
T2886 4391-4393 IN denotes in
T2887 4394-4401 VBG denotes resting
T2888 4402-4408 CD denotes cells6
T2889 4408-4409 , denotes ,
T2890 4410-4412 PRP denotes we
T2891 4413-4425 VBD denotes hypothesized
T2892 4426-4430 IN denotes that
T2893 4431-4440 VBN denotes activated
T2894 4441-4445 NNP denotes IKKβ
T2895 4446-4451 MD denotes might
T2896 4452-4456 RB denotes also
T2897 4457-4461 NN denotes bind
T2898 4462-4464 TO denotes to
T2899 4465-4468 CC denotes and
T2900 4469-4482 VB denotes phosphorylate
T2901 4483-4487 NNP denotes RPS3
T2902 4487-4488 . denotes .
T2903 4489-4494 RB denotes First
T2904 4494-4495 , denotes ,
T2905 4496-4498 PRP denotes we
T2906 4499-4504 VBD denotes found
T2907 4505-4509 IN denotes that
T2908 4510-4521 RB denotes ectopically
T2909 4522-4531 VBN denotes expressed
T2910 4532-4536 NNP denotes IKKβ
T2911 4537-4540 CC denotes and
T2912 4541-4545 NNP denotes RPS3
T2913 4546-4556 VBD denotes interacted
T2914 4557-4558 -LRB- denotes (
T2915 4558-4562 NNP denotes Fig.
T2916 4563-4565 CD denotes 1c
T2917 4565-4566 -RRB- denotes )
T2918 4566-4567 . denotes .
T2919 4568-4570 PRP denotes We
T2920 4571-4575 JJ denotes next
T2921 4576-4584 VBD denotes examined
T2922 4585-4592 VBG denotes resting
T2923 4593-4599 NNP denotes Jurkat
T2924 4600-4605 NNS denotes cells
T2925 4606-4609 CC denotes and
T2926 4610-4618 VBD denotes detected
T2927 4619-4620 DT denotes a
T2928 4621-4627 JJ denotes modest
T2929 4628-4638 JJ denotes endogenous
T2930 4639-4648 JJ denotes IKKβ-RPS3
T2931 4649-4660 NN denotes interaction
T2932 4661-4662 -LRB- denotes (
T2933 4662-4666 NNP denotes Fig.
T2934 4667-4669 CD denotes 1d
T2935 4669-4670 -RRB- denotes )
T2936 4670-4671 , denotes ,
T2937 4672-4683 RB denotes potentially
T2938 4684-4694 VBG denotes accounting
T2939 4695-4698 IN denotes for
T2940 4699-4702 DT denotes the
T2941 4703-4708 JJ denotes basal
T2942 4709-4714 NN denotes NF-κB
T2943 4715-4728 NN denotes transcription
T2944 4729-4737 VBN denotes required
T2945 4738-4741 IN denotes for
T2946 4742-4746 NN denotes cell
T2947 4747-4760 NN denotes proliferation
T2948 4761-4764 CC denotes and
T2949 4765-4773 NN denotes survival
T2950 4773-4774 . denotes .
T2951 4775-4784 JJ denotes RPS3-IKKβ
T2952 4785-4796 NN denotes association
T2953 4797-4800 VBD denotes was
T2954 4801-4808 RB denotes clearly
T2955 4809-4818 VBN denotes augmented
T2956 4819-4823 IN denotes upon
T2957 4824-4827 NNP denotes TNF
T2958 4828-4839 NN denotes stimulation
T2959 4839-4840 , denotes ,
T2960 4841-4848 VBG denotes peaking
T2961 4849-4851 IN denotes at
T2962 4852-4854 CD denotes 10
T2963 4855-4858 NN denotes min
T2964 4858-4859 . denotes .
T2965 4860-4861 -LRB- denotes (
T2966 4861-4865 NNP denotes Fig.
T2967 4866-4868 CD denotes 1d
T2968 4868-4869 -RRB- denotes )
T2969 4869-4870 , denotes ,
T2970 4871-4880 VBG denotes following
T2971 4881-4888 JJ denotes similar
T2972 4889-4897 NNS denotes kinetics
T2973 4898-4900 TO denotes to
T2974 4901-4905 CD denotes RPS3
T2975 4906-4912 NN denotes serine
T2976 4913-4928 NN denotes phosphorylation
T2977 4929-4930 -LRB- denotes (
T2978 4930-4934 NNP denotes Fig.
T2979 4935-4937 CD denotes 1b
T2980 4937-4938 -RRB- denotes )
T2981 4938-4939 . denotes .
T2982 4940-4942 IN denotes By
T2983 4943-4951 NN denotes contrast
T2984 4951-4952 , denotes ,
T2985 4953-4958 EX denotes there
T2986 4959-4962 VBD denotes was
T2987 4963-4965 DT denotes no
T2988 4966-4976 JJ denotes detectable
T2989 4977-4988 NN denotes interaction
T2990 4989-4996 IN denotes between
T2991 4997-5001 CD denotes RPS3
T2992 5002-5005 CC denotes and
T2993 5006-5010 NNP denotes IKKα
T2994 5011-5012 -LRB- denotes (
T2995 5012-5016 NNP denotes Fig.
T2996 5017-5019 CD denotes 1d
T2997 5019-5020 -RRB- denotes )
T2998 5020-5021 . denotes .
T3859 5023-5027 NNP denotes IKKβ
T3860 5028-5030 VBZ denotes is
T3861 5031-5039 VBN denotes required
T3862 5040-5043 IN denotes for
T3863 5044-5048 NNP denotes RPS3
T3864 5049-5056 JJ denotes nuclear
T3865 5057-5070 NN denotes translocation
T3866 5071-5073 TO denotes To
T3867 5074-5081 VB denotes examine
T3868 5082-5089 IN denotes whether
T3869 5090-5093 DT denotes the
T3870 5094-5103 NN denotes RPS3-IKKβ
T3871 5104-5115 NN denotes interaction
T3872 5116-5118 VBZ denotes is
T3873 5119-5127 VBN denotes required
T3874 5128-5131 IN denotes for
T3875 5132-5136 NNP denotes RPS3
T3876 5137-5144 JJ denotes nuclear
T3877 5145-5158 NN denotes translocation
T3878 5158-5159 , denotes ,
T3879 5160-5162 PRP denotes we
T3880 5163-5170 VBD denotes knocked
T3881 5171-5175 RP denotes down
T3882 5176-5180 NNP denotes IKKα
T3883 5181-5183 CC denotes or
T3884 5184-5188 NNP denotes IKKβ
T3885 5189-5199 NN denotes expression
T3886 5200-5204 IN denotes with
T3887 5205-5211 NNS denotes siRNAs
T3888 5212-5213 -LRB- denotes (
T3889 5213-5226 NNP denotes Supplementary
T3890 5227-5231 NNP denotes Fig.
T3891 5232-5233 CD denotes 1
T3892 5233-5234 -RRB- denotes )
T3893 5235-5238 CC denotes and
T3894 5239-5243 RB denotes then
T3895 5244-5252 VBD denotes observed
T3896 5253-5272 JJ denotes stimulation-induced
T3897 5273-5277 NNP denotes RPS3
T3898 5278-5285 JJ denotes nuclear
T3899 5286-5295 NN denotes migration
T3900 5296-5298 IN denotes by
T3901 5299-5307 JJ denotes confocal
T3902 5308-5318 NN denotes microscopy
T3903 5318-5319 . denotes .
T3904 5320-5324 DT denotes Both
T3905 5325-5328 NNP denotes TNF
T3906 5329-5332 CC denotes and
T3907 5333-5338 NNP denotes PMA+I
T3908 5339-5348 VBD denotes triggered
T3909 5349-5353 CD denotes RPS3
T3910 5354-5361 JJ denotes nuclear
T3911 5362-5375 NN denotes translocation
T3912 5376-5378 IN denotes in
T3913 5379-5385 NNP denotes Jurkat
T3914 5386-5391 NNS denotes cells
T3915 5392-5403 VBN denotes transfected
T3916 5404-5408 IN denotes with
T3917 5409-5410 DT denotes a
T3918 5411-5420 VBN denotes scrambled
T3919 5421-5432 JJ denotes nonspecific
T3920 5433-5434 -LRB- denotes (
T3921 5434-5436 NNP denotes NS
T3922 5436-5437 -RRB- denotes )
T3923 5438-5443 NNP denotes siRNA
T3924 5444-5445 -LRB- denotes (
T3925 5445-5449 NNP denotes Fig.
T3926 5450-5452 CD denotes 2a
T3927 5452-5453 -RRB- denotes )
T3928 5453-5454 CD denotes 6
T3929 5454-5455 . denotes .
T3930 5456-5460 CD denotes RPS3
T3931 5461-5468 JJ denotes nuclear
T3932 5469-5482 NN denotes translocation
T3933 5483-5486 VBD denotes was
T3934 5487-5491 RB denotes only
T3935 5492-5500 RB denotes slightly
T3936 5500-5501 , denotes ,
T3937 5502-5504 IN denotes if
T3938 5505-5507 IN denotes at
T3939 5508-5511 DT denotes all
T3940 5511-5512 , denotes ,
T3941 5513-5521 VBN denotes impaired
T3942 5522-5524 IN denotes by
T3943 5525-5539 JJ denotes IKKα-silencing
T3944 5539-5540 . denotes .
T3945 5541-5551 RB denotes Conversely
T3946 5551-5552 , denotes ,
T3947 5553-5562 NN denotes knockdown
T3948 5563-5565 IN denotes of
T3949 5566-5570 NNP denotes IKKβ
T3950 5571-5581 VBD denotes attenuated
T3951 5582-5587 CD denotes 60-70
T3952 5587-5588 NN denotes %
T3953 5589-5591 IN denotes of
T3954 5592-5596 CD denotes RPS3
T3955 5597-5604 JJ denotes nuclear
T3956 5605-5617 NN denotes accumulation
T3957 5618-5627 VBG denotes following
T3958 5628-5639 NN denotes stimulation
T3959 5640-5641 -LRB- denotes (
T3960 5641-5645 NNP denotes Fig.
T3961 5646-5648 CD denotes 2a
T3962 5648-5649 -RRB- denotes )
T3963 5649-5650 . denotes .
T3964 5651-5665 VBG denotes Immunoblotting
T3965 5666-5668 IN denotes of
T3966 5669-5676 JJ denotes nuclear
T3967 5677-5686 NNS denotes fractions
T3968 5687-5696 VBD denotes confirmed
T3969 5697-5701 IN denotes that
T3970 5702-5706 JJ denotes full
T3971 5707-5717 NN denotes expression
T3972 5718-5720 IN denotes of
T3973 5721-5725 NNP denotes IKKβ
T3974 5725-5726 , denotes ,
T3975 5727-5730 CC denotes but
T3976 5731-5734 RB denotes not
T3977 5735-5739 NNP denotes IKKα
T3978 5739-5740 , denotes ,
T3979 5741-5744 VBD denotes was
T3980 5745-5754 JJ denotes necessary
T3981 5755-5758 IN denotes for
T3982 5759-5777 JJ denotes activation-induced
T3983 5778-5782 JJ denotes RPS3
T3984 5783-5790 JJ denotes nuclear
T3985 5791-5804 NN denotes translocation
T3986 5805-5806 -LRB- denotes (
T3987 5806-5810 NNP denotes Fig.
T3988 5811-5813 CD denotes 2b
T3989 5813-5814 -RRB- denotes )
T3990 5814-5815 . denotes .
T3991 5816-5823 NNP denotes Control
T3992 5824-5835 NNS denotes immunoblots
T3993 5836-5844 VBD denotes revealed
T3994 5845-5849 IN denotes that
T3995 5850-5853 CD denotes p65
T3996 5854-5861 JJ denotes nuclear
T3997 5862-5875 NN denotes translocation
T3998 5876-5879 VBD denotes was
T3999 5880-5887 VBN denotes blocked
T4000 5888-5893 IN denotes under
T4001 5894-5897 DT denotes the
T4002 5898-5902 JJ denotes same
T4003 5903-5913 NNS denotes conditions
T4004 5914-5915 -LRB- denotes (
T4005 5915-5919 NNP denotes Fig.
T4006 5920-5922 CD denotes 2b
T4007 5922-5923 -RRB- denotes )
T4008 5923-5924 . denotes .
T4009 5925-5927 PRP denotes We
T4010 5928-5932 JJ denotes next
T4011 5933-5941 VBD denotes examined
T4012 5942-5945 DT denotes the
T4013 5946-5953 JJ denotes nuclear
T4014 5954-5967 NN denotes translocation
T4015 5968-5970 IN denotes of
T4016 5971-5975 CD denotes RPS3
T4017 5976-5978 IN denotes in
T4018 5979-5984 NNS denotes cells
T4019 5985-5996 RB denotes ectopically
T4020 5997-6007 VBG denotes expressing
T4021 6008-6014 CC denotes either
T4022 6015-6026 NN denotes kinase-dead
T4023 6027-6028 -LRB- denotes (
T4024 6028-6032 NNP denotes SSAA
T4025 6032-6033 -RRB- denotes )
T4026 6034-6036 CC denotes or
T4027 6037-6058 JJ denotes constitutively-active
T4028 6059-6060 -LRB- denotes (
T4029 6060-6064 NNP denotes SSEE
T4030 6064-6065 -RRB- denotes )
T4031 6066-6072 JJ denotes mutant
T4032 6073-6077 NNP denotes IKKβ
T4033 6078-6086 NNS denotes proteins
T4034 6086-6087 . denotes .
T4035 6088-6090 IN denotes As
T4036 6091-6099 VBN denotes expected
T4037 6099-6100 , denotes ,
T4038 6101-6104 DT denotes the
T4039 6105-6109 NNP denotes SSEE
T4040 6109-6110 , denotes ,
T4041 6111-6114 CC denotes but
T4042 6115-6118 RB denotes not
T4043 6119-6123 NNP denotes SSAA
T4044 6123-6124 , denotes ,
T4045 6125-6131 JJ denotes mutant
T4046 6132-6134 IN denotes of
T4047 6135-6139 NNP denotes IKKβ
T4048 6140-6147 VBD denotes induced
T4049 6148-6163 JJ denotes NF-κB-dependent
T4050 6164-6174 NN denotes luciferase
T4051 6175-6183 NN denotes reporter
T4052 6184-6192 NN denotes activity
T4053 6193-6194 -LRB- denotes (
T4054 6194-6198 NNP denotes Fig.
T4055 6199-6201 CD denotes 2c
T4056 6201-6202 , denotes ,
T4057 6203-6207 VBD denotes left
T4058 6207-6208 -RRB- denotes )
T4059 6208-6209 . denotes .
T4060 6210-6217 IN denotes Whereas
T4061 6218-6222 CD denotes RPS3
T4062 6223-6231 VBD denotes remained
T4063 6232-6241 JJ denotes cytosolic
T4064 6242-6244 IN denotes in
T4065 6245-6249 NNP denotes IKKβ
T4066 6250-6251 -LRB- denotes (
T4067 6251-6255 NNP denotes SSAA
T4068 6255-6256 -RRB- denotes )
T4069 6256-6257 : denotes -
T4070 6257-6267 VBG denotes expressing
T4071 6268-6273 NNS denotes cells
T4072 6274-6275 -LRB- denotes (
T4073 6275-6279 NNP denotes Fig.
T4074 6280-6282 CD denotes 2c
T4075 6282-6283 , denotes ,
T4076 6284-6289 NN denotes right
T4077 6289-6290 -RRB- denotes )
T4078 6290-6291 , denotes ,
T4079 6292-6293 DT denotes a
T4080 6294-6305 JJ denotes substantial
T4081 6306-6316 NN denotes proportion
T4082 6317-6319 IN denotes of
T4083 6320-6324 CD denotes RPS3
T4084 6325-6337 VBN denotes translocated
T4085 6338-6340 TO denotes to
T4086 6341-6344 DT denotes the
T4087 6345-6352 NN denotes nucleus
T4088 6353-6355 IN denotes in
T4089 6356-6361 NNS denotes cells
T4090 6362-6372 VBG denotes expressing
T4091 6373-6377 NNP denotes IKKβ
T4092 6378-6379 -LRB- denotes (
T4093 6379-6383 NNP denotes SSEE
T4094 6383-6384 -RRB- denotes )
T4095 6385-6386 -LRB- denotes (
T4096 6386-6390 NNP denotes Fig.
T4097 6391-6393 CD denotes 2c
T4098 6393-6394 , denotes ,
T4099 6395-6400 NN denotes right
T4100 6400-6401 -RRB- denotes )
T4101 6401-6402 . denotes .
T4102 6403-6406 DT denotes The
T4103 6407-6417 NN denotes percentage
T4104 6418-6420 IN denotes of
T4105 6421-6426 NNS denotes cells
T4106 6427-6437 VBG denotes containing
T4107 6438-6448 JJ denotes detectable
T4108 6449-6456 JJ denotes nuclear
T4109 6457-6461 NN denotes RPS3
T4110 6462-6471 VBD denotes increased
T4111 6472-6478 JJ denotes 5-fold
T4112 6479-6481 IN denotes in
T4113 6482-6486 NNP denotes IKKβ
T4114 6487-6488 -LRB- denotes (
T4115 6488-6492 NNP denotes SSEE
T4116 6492-6493 -RRB- denotes )
T4117 6493-6494 : denotes -
T4118 6494-6504 VBG denotes expressing
T4119 6505-6510 NNS denotes cells
T4120 6510-6511 , denotes ,
T4121 6512-6515 CC denotes but
T4122 6516-6519 RB denotes not
T4123 6520-6522 IN denotes in
T4124 6523-6527 NNP denotes IKKβ
T4125 6528-6529 -LRB- denotes (
T4126 6529-6533 NNP denotes SSAA
T4127 6533-6534 -RRB- denotes )
T4128 6534-6535 : denotes -
T4129 6535-6545 VBG denotes expressing
T4130 6546-6550 NNS denotes ones
T4131 6551-6552 -LRB- denotes (
T4132 6552-6556 NNP denotes Fig.
T4133 6557-6559 CD denotes 2d
T4134 6560-6563 CC denotes and
T4135 6564-6577 NNP denotes Supplementary
T4136 6578-6582 NNP denotes Fig.
T4137 6583-6584 CD denotes 2
T4138 6584-6585 -RRB- denotes )
T4139 6585-6586 . denotes .
T4140 6587-6591 RB denotes Thus
T4141 6591-6592 , denotes ,
T4142 6593-6597 JJ denotes IKKβ
T4143 6598-6606 NN denotes activity
T4144 6607-6609 VBZ denotes is
T4145 6610-6619 JJ denotes necessary
T4146 6620-6623 CC denotes and
T4147 6624-6634 JJ denotes sufficient
T4148 6635-6638 IN denotes for
T4149 6639-6643 JJ denotes RPS3
T4150 6644-6651 JJ denotes nuclear
T4151 6652-6665 NN denotes translocation
T4152 6666-6668 IN denotes in
T4153 6669-6677 NN denotes response
T4154 6678-6680 TO denotes to
T4155 6681-6686 NNP denotes NF-κB
T4156 6687-6697 VBG denotes activating
T4157 6698-6705 NNS denotes stimuli
T4158 6705-6706 . denotes .
T5617 6708-6712 NNP denotes IκBα
T5618 6713-6724 NN denotes degradation
T5619 6725-6728 CC denotes and
T5620 6729-6733 JJ denotes RPS3
T5621 6734-6741 JJ denotes nuclear
T5622 6742-6755 NN denotes translocation
T5623 6756-6766 NNP denotes Importin-α
T5624 6767-6776 VBZ denotes regulates
T5625 6777-6780 DT denotes the
T5626 6781-6788 JJ denotes nuclear
T5627 6789-6795 NN denotes import
T5628 6796-6798 IN denotes of
T5629 6799-6804 NNP denotes NF-κB
T5630 6805-6808 NNP denotes Rel
T5631 6809-6819 CD denotes subunits23
T5632 6819-6820 , denotes ,
T5633 6821-6823 CD denotes 24
T5634 6823-6824 . denotes .
T5635 6825-6829 CD denotes RPS3
T5636 6830-6837 NNS denotes harbors
T5637 6838-6839 DT denotes a
T5638 6840-6847 JJ denotes nuclear
T5639 6848-6860 NN denotes localization
T5640 6861-6867 NN denotes signal
T5641 6868-6869 -LRB- denotes (
T5642 6869-6872 NNP denotes NLS
T5643 6872-6873 -RRB- denotes )
T5644 6874-6882 NN denotes sequence
T5645 6883-6886 CC denotes and
T5646 6887-6890 PRP$ denotes its
T5647 6891-6898 JJ denotes nuclear
T5648 6899-6912 NN denotes translocation
T5649 6913-6919 VBZ denotes occurs
T5650 6920-6922 IN denotes in
T5651 6923-6931 NN denotes parallel
T5652 6932-6934 TO denotes to
T5653 6934-6935 , denotes ,
T5654 6936-6939 CC denotes but
T5655 6940-6953 RB denotes independently
T5656 6954-6956 IN denotes of
T5657 6956-6957 , denotes ,
T5658 6958-6961 CD denotes p65
T5659 6962-6976 NNS denotes translocation6
T5660 6976-6977 . denotes .
T5661 6978-6980 PRP denotes We
T5662 6981-6991 VBD denotes envisioned
T5663 6992-6996 IN denotes that
T5664 6997-7001 NNP denotes RPS3
T5665 7002-7007 MD denotes could
T5666 7008-7012 RB denotes also
T5667 7013-7020 VB denotes utilize
T5668 7021-7024 DT denotes the
T5669 7025-7035 JJ denotes importin-α
T5670 7035-7036 NN denotes /
T5671 7036-7037 NN denotes β
T5672 7038-7045 NN denotes pathway
T5673 7045-7046 . denotes .
T5674 7047-7057 JJ denotes Consistent
T5675 7058-7062 IN denotes with
T5676 7063-7067 DT denotes this
T5677 7068-7074 NN denotes notion
T5678 7074-7075 , denotes ,
T5679 7076-7080 JJ denotes RPS3
T5680 7081-7092 NN denotes association
T5681 7093-7097 IN denotes with
T5682 7098-7108 JJ denotes importin-α
T5683 7108-7109 , denotes ,
T5684 7110-7113 CC denotes but
T5685 7114-7117 RB denotes not
T5686 7118-7128 JJ denotes importin-β
T5687 7128-7129 , denotes ,
T5688 7130-7133 VBD denotes was
T5689 7134-7142 VBN denotes enhanced
T5690 7143-7145 IN denotes in
T5691 7146-7149 NNP denotes TNF
T5692 7150-7160 VBD denotes stimulated
T5693 7161-7166 NNS denotes cells
T5694 7167-7168 -LRB- denotes (
T5695 7168-7172 NNP denotes Fig.
T5696 7173-7175 CD denotes 3a
T5697 7175-7176 -RRB- denotes )
T5698 7176-7177 . denotes .
T5699 7178-7187 RB denotes Therefore
T5700 7187-7188 , denotes ,
T5701 7189-7191 PRP denotes we
T5702 7192-7200 VBD denotes examined
T5703 7201-7208 IN denotes whether
T5704 7209-7213 NNP denotes RPS3
T5705 7214-7221 JJ denotes binding
T5706 7222-7224 TO denotes to
T5707 7225-7235 NN denotes importin-α
T5708 7236-7238 VBZ denotes is
T5709 7239-7248 JJ denotes essential
T5710 7249-7252 IN denotes for
T5711 7253-7260 JJ denotes nuclear
T5712 7261-7274 NN denotes translocation
T5713 7275-7281 IN denotes during
T5714 7282-7287 NNP denotes NF-κB
T5715 7288-7298 NN denotes activation
T5716 7298-7299 . denotes .
T5717 7300-7305 IN denotes Since
T5718 7306-7310 NNP denotes IκBα
T5719 7311-7322 NN denotes degradation
T5720 7323-7325 VBZ denotes is
T5721 7326-7327 DT denotes a
T5722 7328-7340 NN denotes prerequisite
T5723 7341-7343 TO denotes to
T5724 7344-7350 VB denotes unmask
T5725 7351-7354 DT denotes the
T5726 7355-7358 NNP denotes NLS
T5727 7359-7361 IN denotes of
T5728 7362-7365 CD denotes p65
T5729 7365-7366 , denotes ,
T5730 7367-7370 CC denotes and
T5731 7371-7375 DT denotes both
T5732 7376-7380 CD denotes RPS3
T5733 7381-7384 CC denotes and
T5734 7385-7389 NNP denotes IκBα
T5735 7390-7394 NN denotes bind
T5736 7395-7397 TO denotes to
T5737 7398-7401 VB denotes p65
T5738 7402-7404 IN denotes in
T5739 7405-7408 DT denotes the
T5740 7409-7420 JJ denotes cytoplasmic
T5741 7421-7431 NN denotes inhibitory
T5742 7432-7439 NN denotes complex
T5743 7439-7440 , denotes ,
T5744 7441-7443 PRP denotes we
T5745 7444-7450 VBD denotes tested
T5746 7451-7458 IN denotes whether
T5747 7459-7463 NNP denotes IκBα
T5748 7464-7475 NN denotes degradation
T5749 7476-7478 VBZ denotes is
T5750 7479-7487 VBN denotes required
T5751 7488-7491 IN denotes for
T5752 7492-7495 DT denotes the
T5753 7496-7506 NN denotes liberation
T5754 7507-7509 IN denotes of
T5755 7510-7514 NNP denotes RPS3
T5756 7514-7515 . denotes .
T5757 7516-7518 PRP denotes We
T5758 7519-7527 VBD denotes measured
T5759 7528-7531 DT denotes the
T5760 7532-7543 NN denotes association
T5761 7544-7546 IN denotes of
T5762 7547-7551 CD denotes RPS3
T5763 7552-7556 IN denotes with
T5764 7557-7567 JJ denotes importin-α
T5765 7568-7570 IN denotes in
T5766 7571-7575 JJ denotes 293T
T5767 7576-7581 NNS denotes cells
T5768 7582-7596 VBG denotes overexpressing
T5769 7597-7606 JJ denotes wild-type
T5770 7607-7611 NNP denotes IκBα
T5771 7612-7614 CC denotes or
T5772 7615-7617 DT denotes an
T5773 7618-7622 NNP denotes IκBα
T5774 7623-7629 JJ denotes mutant
T5775 7630-7631 -LRB- denotes (
T5776 7631-7635 NNP denotes SSAA
T5777 7635-7636 -RRB- denotes )
T5778 7637-7646 NN denotes resistant
T5779 7647-7649 TO denotes to
T5780 7650-7662 JJ denotes IKKβ-induced
T5781 7663-7678 NN denotes phosphorylation
T5782 7679-7682 CC denotes and
T5783 7683-7694 NN denotes degradation
T5784 7694-7695 . denotes .
T5785 7696-7698 IN denotes In
T5786 7699-7704 NNS denotes cells
T5787 7705-7716 VBN denotes transfected
T5788 7717-7721 IN denotes with
T5789 7722-7731 JJ denotes wild-type
T5790 7732-7736 NNP denotes IκBα
T5791 7736-7737 , denotes ,
T5792 7738-7741 NNP denotes TNF
T5793 7742-7753 NN denotes stimulation
T5794 7754-7763 VBD denotes augmented
T5795 7764-7767 DT denotes the
T5796 7768-7779 NN denotes interaction
T5797 7780-7782 IN denotes of
T5798 7783-7787 NNP denotes RPS3
T5799 7788-7791 CC denotes and
T5800 7792-7802 JJ denotes importin-α
T5801 7803-7805 TO denotes to
T5802 7806-7807 DT denotes a
T5803 7808-7815 JJ denotes similar
T5804 7816-7822 NN denotes degree
T5805 7823-7825 IN denotes as
T5806 7826-7828 IN denotes in
T5807 7829-7844 JJ denotes non-transfected
T5808 7845-7850 NNS denotes cells
T5809 7850-7851 . denotes .
T5810 7852-7854 IN denotes By
T5811 7855-7863 NN denotes contrast
T5812 7863-7864 , denotes ,
T5813 7865-7867 PRP denotes we
T5814 7868-7876 VBD denotes observed
T5815 7877-7881 IN denotes that
T5816 7882-7885 DT denotes the
T5817 7886-7901 JJ denotes RPS3-importin-α
T5818 7902-7913 NN denotes association
T5819 7914-7917 VBD denotes was
T5820 7918-7927 VBN denotes abolished
T5821 7928-7930 IN denotes by
T5822 7931-7934 DT denotes the
T5823 7935-7943 NN denotes presence
T5824 7944-7946 IN denotes of
T5825 7947-7961 JJ denotes non-degradable
T5826 7962-7966 NNP denotes IκBα
T5827 7967-7968 -LRB- denotes (
T5828 7968-7972 NNP denotes Fig.
T5829 7973-7975 CD denotes 3b
T5830 7975-7976 -RRB- denotes )
T5831 7976-7977 . denotes .
T5832 7978-7980 TO denotes To
T5833 7981-7988 VB denotes examine
T5834 7989-7996 IN denotes whether
T5835 7997-8001 NNP denotes IκBα
T5836 8002-8004 VBZ denotes is
T5837 8005-8008 DT denotes the
T5838 8009-8013 JJ denotes only
T5839 8014-8025 JJ denotes cytoplasmic
T5840 8026-8033 NN denotes barrier
T5841 8034-8044 VBG denotes precluding
T5842 8045-8049 NNP denotes RPS3
T5843 8050-8057 JJ denotes nuclear
T5844 8058-8071 NN denotes translocation
T5845 8071-8072 , denotes ,
T5846 8073-8075 PRP denotes we
T5847 8076-8084 VBD denotes measured
T5848 8085-8089 DT denotes both
T5849 8090-8105 JJ denotes RPS3-importin-α
T5850 8106-8117 NN denotes association
T5851 8118-8121 CC denotes and
T5852 8122-8129 JJ denotes nuclear
T5853 8130-8134 NN denotes RPS3
T5854 8135-8140 IN denotes after
T5855 8141-8149 VBG denotes reducing
T5856 8150-8154 NNP denotes IκBα
T5857 8155-8165 NN denotes expression
T5858 8165-8166 . denotes .
T5859 8167-8175 VBN denotes Compared
T5860 8176-8180 IN denotes with
T5861 8181-8192 JJ denotes nonspecific
T5862 8193-8198 NNP denotes siRNA
T5863 8198-8199 , denotes ,
T5864 8200-8205 NNP denotes siRNA
T5865 8206-8215 VBG denotes targeting
T5866 8216-8218 IN denotes of
T5867 8219-8223 NNP denotes IκBα
T5868 8224-8234 RB denotes completely
T5869 8235-8243 VBD denotes depleted
T5870 8244-8248 NNP denotes IκBα
T5871 8249-8251 IN denotes in
T5872 8252-8258 NNP denotes Jurkat
T5873 8259-8264 NNS denotes cells
T5874 8265-8266 -LRB- denotes (
T5875 8266-8270 NNP denotes Fig.
T5876 8271-8273 CD denotes 3c
T5877 8273-8274 , denotes ,
T5878 8275-8280 NN denotes input
T5879 8280-8281 -RRB- denotes )
T5880 8281-8282 . denotes .
T5881 8283-8295 RB denotes Nevertheless
T5882 8295-8296 , denotes ,
T5883 8297-8300 DT denotes the
T5884 8301-8316 JJ denotes RPS3-importin-α
T5885 8317-8328 NN denotes association
T5886 8329-8332 VBD denotes was
T5887 8333-8336 RB denotes not
T5888 8337-8346 VBN denotes augmented
T5889 8347-8348 -LRB- denotes (
T5890 8348-8352 NNP denotes Fig.
T5891 8353-8355 CD denotes 3c
T5892 8355-8356 -RRB- denotes )
T5893 8356-8357 , denotes ,
T5894 8358-8361 CC denotes nor
T5895 8362-8365 VBD denotes was
T5896 8366-8377 JJ denotes significant
T5897 8378-8385 JJ denotes nuclear
T5898 8386-8390 JJ denotes RPS3
T5899 8391-8399 VBN denotes detected
T5900 8400-8401 -LRB- denotes (
T5901 8401-8405 NNP denotes Fig.
T5902 8406-8408 CD denotes 3d
T5903 8408-8409 -RRB- denotes )
T5904 8409-8410 . denotes .
T5905 8411-8419 RB denotes Moreover
T5906 8419-8420 , denotes ,
T5907 8421-8426 NNS denotes cells
T5908 8427-8434 VBN denotes treated
T5909 8435-8439 IN denotes with
T5910 8440-8446 NN denotes sodium
T5911 8447-8458 NN denotes pervanadate
T5912 8459-8460 -LRB- denotes (
T5913 8460-8462 NNP denotes Pv
T5914 8462-8463 -RRB- denotes )
T5915 8464-8466 TO denotes to
T5916 8467-8473 VB denotes induce
T5917 8474-8478 NNP denotes IκBα
T5918 8479-8490 NN denotes degradation
T5919 8491-8498 IN denotes through
T5920 8499-8501 DT denotes an
T5921 8502-8517 JJ denotes IKK-independent
T5922 8518-8532 NN denotes mechanism25-27
T5923 8533-8536 VBD denotes did
T5924 8537-8540 RB denotes not
T5925 8541-8545 VB denotes show
T5926 8546-8555 JJ denotes increased
T5927 8556-8567 NN denotes association
T5928 8568-8575 IN denotes between
T5929 8576-8580 CD denotes RPS3
T5930 8581-8584 CC denotes and
T5931 8585-8595 JJ denotes importin-α
T5932 8596-8597 -LRB- denotes (
T5933 8597-8601 NNP denotes Fig.
T5934 8602-8604 CD denotes 3e
T5935 8605-8608 CC denotes and
T5936 8609-8622 NNP denotes Supplementary
T5937 8623-8627 NNP denotes Fig.
T5938 8628-8630 CD denotes 3b
T5939 8630-8631 -RRB- denotes )
T5940 8632-8634 CC denotes or
T5941 8635-8642 JJ denotes nuclear
T5942 8643-8655 NN denotes accumulation
T5943 8656-8658 IN denotes of
T5944 8659-8663 NNP denotes RPS3
T5945 8663-8664 , denotes ,
T5946 8665-8672 IN denotes despite
T5947 8673-8681 JJ denotes complete
T5948 8682-8686 NNP denotes IκBα
T5949 8687-8698 NN denotes degradation
T5950 8699-8700 -LRB- denotes (
T5951 8700-8713 NNP denotes Supplementary
T5952 8714-8718 NNP denotes Fig.
T5953 8719-8721 CD denotes 3c
T5954 8721-8722 -RRB- denotes )
T5955 8722-8723 . denotes .
T5956 8724-8726 PRP denotes We
T5957 8727-8734 RB denotes further
T5958 8735-8743 VBD denotes examined
T5959 8744-8751 IN denotes whether
T5960 8752-8753 DT denotes a
T5961 8754-8764 JJ denotes subsequent
T5962 8765-8770 NN denotes NF-κB
T5963 8771-8781 NN denotes activation
T5964 8782-8788 NN denotes signal
T5965 8789-8802 RB denotes independently
T5966 8803-8811 VBZ denotes promotes
T5967 8812-8815 DT denotes the
T5968 8816-8826 JJ denotes importin-α
T5969 8827-8838 NN denotes association
T5970 8839-8842 CC denotes and
T5971 8843-8850 JJ denotes nuclear
T5972 8851-8860 NN denotes transport
T5973 8861-8863 IN denotes of
T5974 8864-8868 CD denotes RPS3
T5975 8869-8874 IN denotes after
T5976 8875-8879 NNP denotes IκBα
T5977 8880-8891 NN denotes degradation
T5978 8891-8892 . denotes .
T5979 8893-8895 PRP denotes We
T5980 8896-8901 VBD denotes found
T5981 8902-8906 IN denotes that
T5982 8907-8910 NNP denotes TNF
T5983 8911-8922 NN denotes stimulation
T5984 8923-8932 VBG denotes following
T5985 8933-8935 NNP denotes Pv
T5986 8936-8945 NN denotes treatment
T5987 8946-8949 VBD denotes was
T5988 8950-8958 VBN denotes required
T5989 8959-8962 IN denotes for
T5990 8963-8966 DT denotes the
T5991 8967-8982 JJ denotes RPS3-importin-α
T5992 8983-8994 NN denotes association
T5993 8994-8995 , denotes ,
T5994 8996-9006 JJ denotes comparable
T5995 9007-9009 TO denotes to
T5996 9010-9013 NNP denotes TNF
T5997 9014-9025 NN denotes stimulation
T5998 9026-9031 RB denotes alone
T5999 9032-9033 -LRB- denotes (
T6000 9033-9037 NNP denotes Fig.
T6001 9038-9040 CD denotes 3e
T6002 9040-9041 -RRB- denotes )
T6003 9041-9042 . denotes .
T6004 9043-9047 RB denotes Thus
T6005 9047-9048 , denotes ,
T6006 9049-9053 NNP denotes IκBα
T6007 9054-9069 NN denotes phosphorylation
T6008 9070-9073 CC denotes and
T6009 9074-9085 NN denotes degradation
T6010 9086-9092 PRP denotes itself
T6011 9093-9095 VBZ denotes is
T6012 9096-9104 VBN denotes required
T6013 9105-9108 CC denotes but
T6014 9109-9112 RB denotes not
T6015 9113-9123 JJ denotes sufficient
T6016 9124-9126 TO denotes to
T6017 9127-9132 VB denotes cause
T6018 9133-9137 JJ denotes RPS3
T6019 9138-9149 NN denotes association
T6020 9150-9154 IN denotes with
T6021 9155-9165 JJ denotes importin-α
T6022 9166-9174 VBN denotes followed
T6023 9175-9177 IN denotes by
T6024 9178-9185 JJ denotes nuclear
T6025 9186-9199 NN denotes translocation
T6026 9199-9200 . denotes .
T6027 9201-9207 RB denotes Rather
T6028 9207-9208 , denotes ,
T6029 9209-9211 DT denotes an
T6030 9212-9222 JJ denotes additional
T6031 9223-9229 NN denotes signal
T6032 9229-9230 , denotes ,
T6033 9231-9242 RB denotes potentially
T6034 9243-9247 NNP denotes IKKβ
T6035 9248-9263 NN denotes phosphorylation
T6036 9264-9266 IN denotes of
T6037 9267-9271 NNP denotes RPS3
T6038 9271-9272 , denotes ,
T6039 9273-9275 VBZ denotes is
T6040 9276-9284 VBN denotes required
T6041 9284-9285 . denotes .
T7671 9287-9291 NNP denotes IKKβ
T7672 9292-9306 VBZ denotes phosphorylates
T7673 9307-9311 CD denotes RPS3
T7674 9312-9314 IN denotes at
T7675 9315-9321 NN denotes serine
T7676 9322-9325 CD denotes 209
T7677 9326-9334 IN denotes Although
T7678 9335-9345 RB denotes originally
T7679 9346-9353 VBN denotes defined
T7680 9354-9356 IN denotes as
T7681 9357-9360 DT denotes the
T7682 9361-9367 NN denotes kinase
T7683 9368-9372 WDT denotes that
T7684 9373-9387 VBZ denotes phosphorylates
T7685 9388-9393 NNP denotes IκB19
T7686 9393-9394 , denotes ,
T7687 9395-9399 NNP denotes IKKβ
T7688 9400-9404 RB denotes also
T7689 9405-9419 VBZ denotes phosphorylates
T7690 9420-9429 JJ denotes unrelated
T7691 9430-9440 NNS denotes substrates
T7692 9441-9450 VBG denotes including
T7693 9451-9458 JJ denotes 14-3-3β
T7694 9459-9462 CC denotes and
T7695 9463-9468 JJ denotes Bcl10
T7696 9468-9469 , denotes ,
T7697 9470-9475 WDT denotes which
T7698 9476-9480 VBP denotes lack
T7699 9481-9484 DT denotes the
T7700 9485-9488 NNP denotes IKK
T7701 9489-9498 NN denotes consensus
T7702 9499-9504 NN denotes motif
T7703 9505-9506 -LRB- denotes (
T7704 9506-9516 NNP denotes DpSGYXpS/T
T7705 9516-9517 -RRB- denotes )
T7706 9517-9519 CD denotes 28
T7707 9519-9520 . denotes .
T7708 9521-9523 PRP denotes We
T7709 9524-9533 RB denotes therefore
T7710 9534-9546 VBD denotes hypothesized
T7711 9547-9551 IN denotes that
T7712 9552-9556 NNP denotes IKKβ
T7713 9557-9562 MD denotes could
T7714 9563-9571 RB denotes directly
T7715 9572-9585 VB denotes phosphorylate
T7716 9586-9590 NNP denotes RPS3
T7717 9590-9591 . denotes .
T7718 9592-9594 IN denotes By
T7719 9595-9597 IN denotes in
T7720 9598-9603 NN denotes vitro
T7721 9604-9610 NN denotes kinase
T7722 9611-9617 VBZ denotes assays
T7723 9618-9623 VBG denotes using
T7724 9624-9635 JJ denotes recombinant
T7725 9636-9639 NNP denotes IKK
T7726 9640-9643 CC denotes and
T7727 9644-9648 NNP denotes RPS3
T7728 9649-9657 NNS denotes proteins
T7729 9657-9658 , denotes ,
T7730 9659-9661 PRP denotes we
T7731 9662-9670 VBD denotes observed
T7732 9671-9677 JJ denotes strong
T7733 9678-9691 NN denotes incorporation
T7734 9692-9694 IN denotes of
T7735 9695-9698 NNP denotes 32P
T7736 9699-9701 IN denotes in
T7737 9702-9719 NN denotes autophosphorylatd
T7738 9720-9724 NNP denotes IKKα
T7739 9725-9728 CC denotes and
T7740 9729-9733 NNP denotes IKKβ
T7741 9734-9735 -LRB- denotes (
T7742 9735-9739 NNP denotes Fig.
T7743 9740-9742 CD denotes 4a
T7744 9742-9743 , denotes ,
T7745 9744-9749 NNS denotes lanes
T7746 9750-9753 JJ denotes 2-7
T7747 9753-9754 -RRB- denotes )
T7748 9755-9757 RB denotes as
T7749 9758-9762 RB denotes well
T7750 9763-9765 IN denotes as
T7751 9766-9779 VBN denotes phosporylated
T7752 9780-9788 NNP denotes GST-IκBα
T7753 9789-9790 -LRB- denotes (
T7754 9790-9794 CD denotes 1-54
T7755 9794-9795 -RRB- denotes )
T7756 9796-9797 -LRB- denotes (
T7757 9797-9810 NNP denotes Supplementary
T7758 9811-9815 NNP denotes Fig.
T7759 9816-9817 LS denotes 4
T7760 9817-9818 -RRB- denotes )
T7761 9818-9819 , denotes ,
T7762 9820-9823 CC denotes but
T7763 9824-9827 RB denotes not
T7764 9828-9831 DT denotes the
T7765 9832-9835 NNP denotes GST
T7766 9836-9843 NN denotes protein
T7767 9844-9849 RB denotes alone
T7768 9850-9851 -LRB- denotes (
T7769 9851-9855 NNP denotes Fig.
T7770 9856-9858 CD denotes 4a
T7771 9858-9859 , denotes ,
T7772 9860-9865 NNS denotes lanes
T7773 9866-9867 CD denotes 3
T7774 9868-9871 CC denotes and
T7775 9872-9873 CD denotes 6
T7776 9873-9874 -RRB- denotes )
T7777 9874-9875 , denotes ,
T7778 9876-9880 WRB denotes when
T7779 9881-9887 CC denotes either
T7780 9888-9892 NNP denotes IKKα
T7781 9893-9895 CC denotes or
T7782 9896-9900 NNP denotes IKKβ
T7783 9901-9904 VBD denotes was
T7784 9905-9909 VBN denotes used
T7785 9909-9910 . denotes .
T7786 9911-9913 PRP denotes We
T7787 9914-9924 VBD denotes discovered
T7788 9925-9929 IN denotes that
T7789 9930-9938 NN denotes GST-RPS3
T7790 9939-9944 MD denotes could
T7791 9945-9947 VB denotes be
T7792 9948-9962 VBN denotes phosphorylated
T7793 9963-9965 IN denotes by
T7794 9966-9970 NNP denotes IKKβ
T7795 9970-9971 , denotes ,
T7796 9972-9975 CC denotes but
T7797 9976-9979 RB denotes not
T7798 9980-9984 NNP denotes IKKα
T7799 9984-9985 , denotes ,
T7800 9986-9988 IN denotes in
T7801 9989-9994 NN denotes vitro
T7802 9995-9996 -LRB- denotes (
T7803 9996-10000 NNP denotes Fig.
T7804 10001-10003 CD denotes 4a
T7805 10003-10004 , denotes ,
T7806 10005-10012 VBP denotes compare
T7807 10013-10018 NNS denotes lanes
T7808 10019-10020 CD denotes 4
T7809 10021-10024 CC denotes and
T7810 10025-10026 CD denotes 7
T7811 10026-10027 -RRB- denotes )
T7812 10027-10028 . denotes .
T7813 10029-10031 TO denotes To
T7814 10032-10040 VB denotes identify
T7815 10041-10044 DT denotes the
T7816 10045-10049 JJ denotes RPS3
T7817 10050-10055 JJ denotes amino
T7818 10056-10060 NN denotes acid
T7819 10061-10068 NN denotes residue
T7820 10068-10069 -LRB- denotes (
T7821 10069-10070 PRP denotes s
T7822 10070-10071 -RRB- denotes )
T7823 10072-10086 VBN denotes phosphorylated
T7824 10087-10089 IN denotes by
T7825 10090-10094 NNP denotes IKKβ
T7826 10094-10095 , denotes ,
T7827 10096-10098 PRP denotes we
T7828 10099-10108 VBD denotes performed
T7829 10109-10115 JJ denotes liquid
T7830 10116-10137 NN denotes chromatography-tandem
T7831 10138-10142 NN denotes mass
T7832 10143-10155 NN denotes spectrometry
T7833 10156-10164 VBZ denotes analyses
T7834 10165-10170 VBG denotes using
T7835 10171-10173 IN denotes in
T7836 10174-10179 NN denotes vitro
T7837 10180-10194 VBN denotes phosphorylated
T7838 10195-10199 NNP denotes RPS3
T7839 10199-10200 . denotes .
T7840 10201-10204 DT denotes The
T7841 10205-10212 NNS denotes results
T7842 10213-10222 VBD denotes indicated
T7843 10223-10227 IN denotes that
T7844 10228-10232 NNP denotes IKKβ
T7845 10233-10247 VBD denotes phosphorylated
T7846 10248-10252 CD denotes S209
T7847 10252-10253 , denotes ,
T7848 10254-10261 VBN denotes located
T7849 10262-10264 IN denotes in
T7850 10265-10268 DT denotes the
T7851 10269-10273 NNP denotes RPS3
T7852 10274-10284 NNP denotes C-terminus
T7853 10285-10286 -LRB- denotes (
T7854 10286-10290 NNP denotes Fig.
T7855 10291-10293 CD denotes 4b
T7856 10293-10294 -RRB- denotes )
T7857 10294-10295 . denotes .
T7858 10296-10300 CD denotes RPS3
T7859 10301-10306 JJ denotes amino
T7860 10307-10311 NN denotes acid
T7861 10312-10320 NN denotes sequence
T7862 10321-10330 NN denotes alignment
T7863 10331-10339 VBD denotes revealed
T7864 10340-10344 IN denotes that
T7865 10345-10349 CD denotes S209
T7866 10350-10352 VBZ denotes is
T7867 10353-10362 VBN denotes conserved
T7868 10363-10365 IN denotes in
T7869 10366-10370 JJ denotes many
T7870 10371-10378 NNS denotes species
T7871 10379-10389 IN denotes throughout
T7872 10390-10399 NN denotes phylogeny
T7873 10400-10404 IN denotes with
T7874 10405-10408 DT denotes the
T7875 10409-10418 NN denotes exception
T7876 10419-10421 IN denotes of
T7877 10422-10436 NNP denotes Caenorhabditis
T7878 10437-10444 NNS denotes elegans
T7879 10445-10448 CC denotes and
T7880 10449-10468 NNS denotes Schizosaccharomyces
T7881 10469-10474 VBP denotes pombe
T7882 10474-10475 , denotes ,
T7883 10476-10479 CD denotes two
T7884 10480-10489 NNS denotes organisms
T7885 10490-10494 WDT denotes that
T7886 10495-10497 VBP denotes do
T7887 10498-10501 RB denotes not
T7888 10502-10509 VB denotes possess
T7889 10510-10513 DT denotes the
T7890 10514-10519 JJ denotes NF-κB
T7891 10520-10526 NN denotes signal
T7892 10527-10534 NN denotes pathway
T7893 10535-10536 -LRB- denotes (
T7894 10536-10549 NNP denotes Supplementary
T7895 10550-10554 NNP denotes Fig.
T7896 10555-10556 CD denotes 5
T7897 10556-10557 -RRB- denotes )
T7898 10557-10558 . denotes .
T7899 10559-10561 TO denotes To
T7900 10562-10568 VB denotes verify
T7901 10569-10582 RB denotes biochemically
T7902 10583-10587 IN denotes that
T7903 10588-10592 CD denotes S209
T7904 10593-10595 VBZ denotes is
T7905 10596-10598 DT denotes an
T7906 10599-10603 JJ denotes IKKβ
T7907 10604-10613 NN denotes substrate
T7908 10613-10614 , denotes ,
T7909 10615-10617 PRP denotes we
T7910 10618-10627 VBD denotes performed
T7911 10628-10640 NN denotes 32P-labeling
T7912 10641-10643 IN denotes in
T7913 10644-10649 NN denotes vitro
T7914 10650-10656 NN denotes kinase
T7915 10657-10663 NNS denotes assays
T7916 10664-10668 IN denotes with
T7917 10669-10680 JJ denotes recombinant
T7918 10681-10690 JJ denotes wild-type
T7919 10691-10693 CC denotes or
T7920 10694-10699 JJ denotes S209A
T7921 10700-10706 JJ denotes mutant
T7922 10707-10711 NN denotes RPS3
T7923 10712-10720 NNS denotes proteins
T7924 10720-10721 . denotes .
T7925 10722-10730 VBN denotes Compared
T7926 10731-10735 IN denotes with
T7927 10736-10739 DT denotes the
T7928 10740-10749 JJ denotes wild-type
T7929 10750-10757 NN denotes protein
T7930 10757-10758 , denotes ,
T7931 10759-10762 DT denotes the
T7932 10763-10768 NNP denotes S209A
T7933 10769-10777 NN denotes mutation
T7934 10778-10785 VBD denotes reduced
T7935 10786-10790 NNP denotes IKKβ
T7936 10791-10799 VBD denotes mediated
T7937 10800-10804 JJ denotes RPS3
T7938 10805-10820 NN denotes phosphorylation
T7939 10821-10822 -LRB- denotes (
T7940 10822-10826 NNP denotes Fig.
T7941 10827-10829 CD denotes 4c
T7942 10829-10830 -RRB- denotes )
T7943 10830-10831 . denotes .
T7944 10832-10837 EX denotes There
T7945 10838-10843 MD denotes might
T7946 10844-10846 VB denotes be
T7947 10847-10858 JJ denotes alternative
T7948 10859-10874 NN denotes phosphorylation
T7949 10875-10879 NN denotes site
T7950 10879-10880 -LRB- denotes (
T7951 10880-10881 PRP denotes s
T7952 10881-10882 -RRB- denotes )
T7953 10883-10888 IN denotes under
T7954 10889-10894 DT denotes these
T7955 10895-10905 NNS denotes conditions
T7956 10906-10911 VBN denotes given
T7957 10912-10918 JJ denotes modest
T7958 10919-10927 JJ denotes residual
T7959 10928-10942 VBN denotes phosphorylated
T7960 10943-10947 NNP denotes RPS3
T7961 10948-10949 -LRB- denotes (
T7962 10949-10953 NNP denotes Fig.
T7963 10954-10956 CD denotes 4c
T7964 10956-10957 -RRB- denotes )
T7965 10957-10958 . denotes .
T7966 10959-10963 CD denotes RPS3
T7967 10964-10968 CD denotes S209
T7968 10969-10973 VBZ denotes does
T7969 10974-10977 RB denotes not
T7970 10978-10982 VB denotes fall
T7971 10983-10989 IN denotes within
T7972 10990-10991 DT denotes a
T7973 10992-11004 JJ denotes conventional
T7974 11005-11008 NNP denotes IKK
T7975 11009-11020 NN denotes recognition
T7976 11021-11026 NN denotes motif
T7977 11026-11027 , denotes ,
T7978 11028-11031 CC denotes but
T7979 11032-11038 RB denotes rather
T7980 11039-11046 VBZ denotes resides
T7981 11047-11049 IN denotes in
T7982 11050-11051 DT denotes a
T7983 11052-11060 NN denotes sequence
T7984 11061-11066 NN denotes motif
T7985 11067-11068 -LRB- denotes (
T7986 11068-11078 NNP denotes XXXpS/TXXE
T7987 11078-11079 -RRB- denotes )
T7988 11079-11080 , denotes ,
T7989 11081-11092 RB denotes potentially
T7990 11093-11103 VBN denotes recognized
T7991 11104-11106 IN denotes by
T7992 11107-11113 NN denotes casein
T7993 11114-11120 NN denotes kinase
T7994 11121-11123 NNP denotes II
T7995 11124-11125 -LRB- denotes (
T7996 11125-11128 NNP denotes CK2
T7997 11128-11129 -RRB- denotes )
T7998 11129-11130 . denotes .
T7999 11131-11139 IN denotes Although
T8000 11140-11144 NNP denotes IKKβ
T8001 11145-11151 NN denotes kinase
T8002 11152-11155 MD denotes can
T8003 11156-11163 VB denotes display
T8004 11164-11165 DT denotes a
T8005 11166-11174 JJ denotes CK2-like
T8006 11175-11190 NN denotes phosphorylation
T8007 11191-11204 NNS denotes specificity29
T8008 11204-11205 , denotes ,
T8009 11206-11208 DT denotes no
T8010 11209-11212 NN denotes CK2
T8011 11213-11220 NN denotes protein
T8012 11221-11224 VBD denotes was
T8013 11225-11235 JJ denotes detectable
T8014 11236-11238 IN denotes in
T8015 11239-11242 PRP$ denotes our
T8016 11243-11254 JJ denotes recombinant
T8017 11255-11258 NNP denotes IKK
T8018 11259-11267 NNS denotes proteins
T8019 11268-11269 -LRB- denotes (
T8020 11269-11282 NNP denotes Supplementary
T8021 11283-11287 NNP denotes Fig.
T8022 11288-11289 CD denotes 6
T8023 11289-11290 -RRB- denotes )
T8024 11290-11291 . denotes .
T8025 11292-11296 RB denotes Thus
T8026 11296-11297 , denotes ,
T8027 11298-11302 NNP denotes RPS3
T8028 11303-11307 NNP denotes S209
T8029 11308-11323 NN denotes phosphorylation
T8030 11324-11327 VBD denotes was
T8031 11328-11331 JJ denotes due
T8032 11332-11334 TO denotes to
T8033 11335-11338 DT denotes the
T8034 11339-11348 JJ denotes alternate
T8035 11349-11360 NN denotes specificity
T8036 11361-11363 IN denotes of
T8037 11364-11367 DT denotes the
T8038 11368-11372 NNP denotes IKKβ
T8039 11373-11379 NN denotes kinase
T8040 11380-11386 RB denotes rather
T8041 11387-11391 IN denotes than
T8042 11392-11395 DT denotes any
T8043 11396-11401 VBP denotes trace
T8044 11402-11408 NN denotes amount
T8045 11409-11411 IN denotes of
T8046 11412-11415 CD denotes CK2
T8047 11416-11421 VBN denotes bound
T8048 11422-11424 TO denotes to
T8049 11425-11429 NNS denotes IKKs
T8050 11429-11430 . denotes .
T8051 11431-11433 TO denotes To
T8052 11434-11443 VB denotes determine
T8053 11444-11451 IN denotes whether
T8054 11452-11456 NNP denotes S209
T8055 11457-11459 VBZ denotes is
T8056 11460-11463 DT denotes the
T8057 11464-11472 JJ denotes critical
T8058 11473-11477 NN denotes site
T8059 11478-11480 IN denotes at
T8060 11481-11486 WDT denotes which
T8061 11487-11491 NNP denotes IKKβ
T8062 11492-11506 VBZ denotes phosphorylates
T8063 11507-11511 NNP denotes RPS3
T8064 11512-11514 IN denotes in
T8065 11515-11521 VBG denotes living
T8066 11522-11527 NNS denotes cells
T8067 11527-11528 , denotes ,
T8068 11529-11531 PRP denotes we
T8069 11532-11543 VBD denotes transfected
T8070 11544-11547 DT denotes the
T8071 11548-11557 JJ denotes wild-type
T8072 11558-11560 CC denotes or
T8073 11561-11566 JJ denotes S209A
T8074 11567-11573 JJ denotes mutant
T8075 11574-11583 NN denotes Flag-RPS3
T8076 11584-11589 RB denotes alone
T8077 11589-11590 , denotes ,
T8078 11591-11593 CC denotes or
T8079 11594-11602 RB denotes together
T8080 11603-11607 IN denotes with
T8081 11608-11612 NNP denotes IKKβ
T8082 11613-11617 IN denotes into
T8083 11618-11623 NNS denotes cells
T8084 11623-11624 . denotes .
T8085 11625-11631 RB denotes Indeed
T8086 11631-11632 , denotes ,
T8087 11633-11635 PRP denotes we
T8088 11636-11644 VBD denotes observed
T8089 11645-11649 IN denotes that
T8090 11650-11664 VBG denotes overexpressing
T8091 11665-11669 NNP denotes IKKβ
T8092 11670-11678 JJ denotes enhanced
T8093 11679-11688 NN denotes Flag-RPS3
T8094 11689-11704 NN denotes phosphorylation
T8095 11704-11705 , denotes ,
T8096 11706-11709 CC denotes but
T8097 11710-11725 NN denotes phosphorylation
T8098 11726-11729 VBD denotes was
T8099 11730-11741 RB denotes effectively
T8100 11742-11752 VBN denotes eliminated
T8101 11753-11755 IN denotes by
T8102 11756-11763 JJ denotes alanine
T8103 11764-11776 NN denotes substitution
T8104 11777-11787 VBG denotes indicating
T8105 11788-11792 IN denotes that
T8106 11793-11797 CD denotes S209
T8107 11798-11800 VBZ denotes is
T8108 11801-11804 DT denotes the
T8109 11805-11816 JJ denotes predominant
T8110 11817-11823 NN denotes target
T8111 11824-11828 NN denotes site
T8112 11829-11832 IN denotes for
T8113 11833-11837 NNP denotes IKKβ
T8114 11838-11853 NN denotes phosphorylation
T8115 11854-11855 -LRB- denotes (
T8116 11855-11859 NNP denotes Fig.
T8117 11860-11862 CD denotes 4d
T8118 11862-11863 -RRB- denotes )
T8119 11863-11864 . denotes .
T8120 11865-11867 PRP denotes We
T8121 11868-11872 JJ denotes next
T8122 11873-11882 VBD denotes generated
T8123 11883-11884 DT denotes a
T8124 11885-11897 JJ denotes phospho-S209
T8125 11898-11902 NN denotes RPS3
T8126 11903-11911 NN denotes antibody
T8127 11912-11915 CC denotes and
T8128 11916-11925 VBD denotes confirmed
T8129 11926-11930 IN denotes that
T8130 11931-11941 JJ denotes endogenous
T8131 11942-11946 NN denotes RPS3
T8132 11947-11950 VBD denotes was
T8133 11951-11965 VBN denotes phosphorylated
T8134 11966-11968 IN denotes at
T8135 11969-11973 CD denotes S209
T8136 11974-11976 IN denotes in
T8137 11977-11978 DT denotes a
T8138 11979-11993 JJ denotes time-dependent
T8139 11994-12000 NN denotes manner
T8140 12001-12005 IN denotes upon
T8141 12006-12009 NNP denotes TNF
T8142 12010-12021 NN denotes stimulation
T8143 12022-12023 -LRB- denotes (
T8144 12023-12027 NNP denotes Fig.
T8145 12028-12030 CD denotes 4e
T8146 12030-12031 -RRB- denotes )
T8147 12031-12032 . denotes .
T8148 12033-12037 RB denotes Thus
T8149 12037-12038 , denotes ,
T8150 12039-12042 DT denotes the
T8151 12043-12047 NNP denotes RPS3
T8152 12048-12058 NNP denotes C-terminal
T8153 12059-12063 NN denotes tail
T8154 12064-12075 RB denotes potentially
T8155 12076-12084 VBZ denotes contains
T8156 12085-12087 DT denotes an
T8157 12088-12097 JJ denotes important
T8158 12098-12108 JJ denotes regulatory
T8159 12109-12113 NN denotes site
T8160 12113-12114 . denotes .
T9857 12116-12131 NNP denotes Phosphorylation
T9858 12132-12134 IN denotes of
T9859 12135-12139 NNP denotes RPS3
T9860 12140-12143 CC denotes and
T9861 12144-12147 PRP$ denotes its
T9862 12148-12153 JJ denotes NF-κB
T9863 12154-12162 NN denotes function
T9864 12163-12165 PRP denotes We
T9865 12166-12170 JJ denotes next
T9866 12171-12179 VBD denotes examined
T9867 12180-12187 IN denotes whether
T9868 12188-12192 NNP denotes S209
T9869 12193-12208 NN denotes phosphorylation
T9870 12209-12214 VBZ denotes plays
T9871 12215-12216 DT denotes a
T9872 12217-12221 NN denotes role
T9873 12222-12224 IN denotes in
T9874 12225-12228 DT denotes the
T9875 12229-12236 JJ denotes nuclear
T9876 12237-12250 NN denotes translocation
T9877 12251-12253 IN denotes of
T9878 12254-12258 CD denotes RPS3
T9879 12259-12265 IN denotes during
T9880 12266-12271 JJ denotes NF-κB
T9881 12272-12282 NN denotes activation
T9882 12282-12283 . denotes .
T9883 12284-12295 JJ denotes Subcellular
T9884 12296-12305 NNS denotes fractions
T9885 12306-12310 IN denotes from
T9886 12311-12317 DT denotes either
T9887 12318-12327 JJ denotes wild-type
T9888 12328-12330 CC denotes or
T9889 12331-12336 JJ denotes S209A
T9890 12337-12343 JJ denotes mutant
T9891 12344-12360 JJ denotes RPS3-transfected
T9892 12361-12366 NNS denotes cells
T9893 12367-12371 VBD denotes were
T9894 12372-12380 VBN denotes prepared
T9895 12381-12384 CC denotes and
T9896 12385-12392 VBN denotes blotted
T9897 12393-12396 IN denotes for
T9898 12397-12407 JJ denotes heat-shock
T9899 12408-12415 NN denotes protein
T9900 12416-12418 CD denotes 90
T9901 12419-12420 -LRB- denotes (
T9902 12420-12425 CD denotes hsp90
T9903 12425-12426 -RRB- denotes )
T9904 12426-12427 , denotes ,
T9905 12428-12429 DT denotes a
T9906 12430-12441 JJ denotes cytoplasmic
T9907 12442-12449 NN denotes protein
T9908 12449-12450 , denotes ,
T9909 12451-12454 CC denotes and
T9910 12455-12459 NN denotes poly
T9911 12460-12461 -LRB- denotes (
T9912 12461-12471 JJ denotes ADP-ribose
T9913 12471-12472 -RRB- denotes )
T9914 12473-12483 NN denotes polymerase
T9915 12484-12485 -LRB- denotes (
T9916 12485-12489 NNP denotes PARP
T9917 12489-12490 -RRB- denotes )
T9918 12490-12491 , denotes ,
T9919 12492-12493 DT denotes a
T9920 12494-12501 JJ denotes nuclear
T9921 12502-12509 NN denotes protein
T9922 12509-12510 , denotes ,
T9923 12511-12521 VBG denotes confirming
T9924 12522-12523 DT denotes a
T9925 12524-12529 JJ denotes clean
T9926 12530-12540 NN denotes separation
T9927 12541-12542 -LRB- denotes (
T9928 12542-12546 NNP denotes Fig.
T9929 12547-12549 CD denotes 5a
T9930 12549-12550 -RRB- denotes )
T9931 12550-12551 . denotes .
T9932 12552-12554 IN denotes As
T9933 12555-12563 VBN denotes expected
T9934 12563-12564 , denotes ,
T9935 12565-12570 NNP denotes PMA+I
T9936 12571-12582 NN denotes stimulation
T9937 12583-12592 VBD denotes triggered
T9938 12593-12602 JJ denotes wild-type
T9939 12603-12612 NN denotes Flag-RPS3
T9940 12613-12620 JJ denotes nuclear
T9941 12621-12634 NN denotes translocation
T9942 12635-12636 -LRB- denotes (
T9943 12636-12640 NNP denotes Fig.
T9944 12641-12643 CD denotes 5a
T9945 12643-12644 -RRB- denotes )
T9946 12644-12645 . denotes .
T9947 12646-12653 RB denotes However
T9948 12653-12654 , denotes ,
T9949 12655-12659 NNP denotes RPS3
T9950 12660-12661 -LRB- denotes (
T9951 12661-12666 NNP denotes S209A
T9952 12666-12667 -RRB- denotes )
T9953 12668-12675 JJ denotes nuclear
T9954 12676-12689 NN denotes translocation
T9955 12690-12693 VBD denotes was
T9956 12694-12704 VBN denotes attenuated
T9957 12705-12706 -LRB- denotes (
T9958 12706-12710 NNP denotes Fig.
T9959 12711-12713 CD denotes 5a
T9960 12713-12714 -RRB- denotes )
T9961 12714-12715 . denotes .
T9962 12716-12718 PRP denotes We
T9963 12719-12723 RB denotes also
T9964 12724-12730 VBD denotes tested
T9965 12731-12734 DT denotes the
T9966 12735-12741 NN denotes impact
T9967 12742-12744 IN denotes of
T9968 12745-12755 VBG denotes activating
T9969 12756-12761 NN denotes NF-κB
T9970 12762-12764 IN denotes by
T9971 12765-12779 VBG denotes overexpressing
T9972 12780-12784 NNP denotes IKKβ
T9973 12785-12787 IN denotes on
T9974 12788-12792 NNP denotes RPS3
T9975 12793-12800 JJ denotes nuclear
T9976 12801-12814 NN denotes translocation
T9977 12814-12815 . denotes .
T9978 12816-12820 NNP denotes IKKβ
T9979 12821-12835 NN denotes overexpression
T9980 12836-12845 VBD denotes activated
T9981 12846-12851 JJ denotes NF-κB
T9982 12852-12860 VBN denotes measured
T9983 12861-12863 IN denotes by
T9984 12864-12874 NN denotes luciferase
T9985 12875-12881 NNS denotes assays
T9986 12882-12883 -LRB- denotes (
T9987 12883-12896 NNP denotes Supplementary
T9988 12897-12901 NNP denotes Fig.
T9989 12902-12903 CD denotes 7
T9990 12903-12904 -RRB- denotes )
T9991 12904-12905 , denotes ,
T9992 12906-12909 CC denotes and
T9993 12910-12914 RB denotes also
T9994 12915-12922 VBD denotes induced
T9995 12923-12926 DT denotes the
T9996 12927-12934 JJ denotes nuclear
T9997 12935-12948 NN denotes translocation
T9998 12949-12951 IN denotes of
T9999 12952-12961 JJ denotes wild-type
T10000 12961-12962 , denotes ,
T10001 12963-12966 CC denotes but
T10002 12967-12970 RB denotes not
T10003 12971-12976 NNP denotes S209A
T10004 12976-12977 , denotes ,
T10005 12978-12982 NNP denotes RPS3
T10006 12983-12984 -LRB- denotes (
T10007 12984-12988 NNP denotes Fig.
T10008 12989-12991 CD denotes 5b
T10009 12991-12992 -RRB- denotes )
T10010 12992-12993 . denotes .
T10011 12994-12999 DT denotes These
T10012 13000-13004 NNS denotes data
T10013 13005-13012 VBP denotes suggest
T10014 13013-13017 IN denotes that
T10015 13018-13022 CD denotes S209
T10016 13023-13038 NN denotes phosphorylation
T10017 13039-13041 VBZ denotes is
T10018 13042-13050 JJ denotes critical
T10019 13051-13054 IN denotes for
T10020 13055-13058 DT denotes the
T10021 13059-13064 NNP denotes NF-κB
T10022 13065-13083 VBD denotes activation-induced
T10023 13084-13088 CD denotes RPS3
T10024 13089-13096 JJ denotes nuclear
T10025 13097-13110 NN denotes translocation
T10026 13110-13111 . denotes .
T10027 13112-13114 TO denotes To
T10028 13115-13122 VB denotes examine
T10029 13123-13126 DT denotes the
T10030 13127-13131 NN denotes role
T10031 13132-13134 IN denotes of
T10032 13135-13139 CD denotes S209
T10033 13140-13155 NN denotes phosphorylation
T10034 13156-13158 IN denotes of
T10035 13159-13163 CD denotes RPS3
T10036 13164-13166 TO denotes to
T10037 13167-13170 PRP$ denotes its
T10038 13171-13176 NNP denotes NF-κB
T10039 13177-13186 CD denotes function6
T10040 13186-13187 , denotes ,
T10041 13188-13189 CD denotes 7
T10042 13189-13190 , denotes ,
T10043 13191-13193 CD denotes 30
T10044 13193-13194 , denotes ,
T10045 13195-13197 PRP denotes we
T10046 13198-13206 VBD denotes silenced
T10047 13207-13217 JJ denotes endogenous
T10048 13218-13222 NNP denotes RPS3
T10049 13223-13233 NN denotes expression
T10050 13234-13239 VBG denotes using
T10051 13240-13242 DT denotes an
T10052 13243-13248 NN denotes siRNA
T10053 13249-13253 WDT denotes that
T10054 13254-13261 VBZ denotes targets
T10055 13262-13265 DT denotes the
T10056 13266-13267 CD denotes 3
T10057 13267-13268 NN denotes
T10058 13269-13281 JJ denotes untranslated
T10059 13282-13288 NN denotes region
T10060 13289-13290 -LRB- denotes (
T10061 13290-13291 CD denotes 3
T10062 13291-13292 CD denotes
T10063 13293-13296 NNP denotes UTR
T10064 13296-13297 -RRB- denotes )
T10065 13298-13300 IN denotes of
T10066 13301-13305 CD denotes RPS3
T10067 13306-13310 NNP denotes mRNA
T10068 13310-13311 , denotes ,
T10069 13312-13320 VBN denotes followed
T10070 13321-13323 IN denotes by
T10071 13324-13339 NN denotes complementation
T10072 13340-13344 IN denotes with
T10073 13345-13351 DT denotes either
T10074 13352-13361 JJ denotes wild-type
T10075 13362-13364 CC denotes or
T10076 13365-13370 JJ denotes S209A
T10077 13371-13377 JJ denotes mutant
T10078 13378-13382 NN denotes RPS3
T10079 13383-13386 IN denotes via
T10080 13387-13399 NN denotes transfection
T10081 13399-13400 . denotes .
T10082 13401-13403 IN denotes As
T10083 13404-13412 VBN denotes expected
T10084 13412-13413 , denotes ,
T10085 13414-13418 NNP denotes RPS3
T10086 13419-13424 NNP denotes siRNA
T10087 13425-13433 RB denotes severely
T10088 13434-13441 VBD denotes reduced
T10089 13442-13452 JJ denotes endogenous
T10090 13453-13457 NNP denotes RPS3
T10091 13458-13467 NN denotes abundance
T10092 13468-13476 VBN denotes compared
T10093 13477-13479 TO denotes to
T10094 13480-13482 NNP denotes NS
T10095 13483-13488 NNP denotes siRNA
T10096 13488-13489 , denotes ,
T10097 13490-13493 CC denotes but
T10098 13494-13497 VBD denotes did
T10099 13498-13501 RB denotes not
T10100 13502-13508 VB denotes affect
T10101 13509-13512 DT denotes the
T10102 13513-13519 JJ denotes robust
T10103 13520-13530 NN denotes expression
T10104 13531-13533 IN denotes of
T10105 13534-13545 JJ denotes Flag-tagged
T10106 13546-13550 NN denotes RPS3
T10107 13551-13555 IN denotes from
T10108 13556-13557 DT denotes a
T10109 13558-13569 VBN denotes transfected
T10110 13570-13579 VBP denotes construct
T10111 13580-13587 VBG denotes lacking
T10112 13588-13591 DT denotes the
T10113 13592-13593 CD denotes 3
T10114 13593-13594 NN denotes
T10115 13595-13598 NNP denotes UTR
T10116 13599-13600 -LRB- denotes (
T10117 13600-13604 NNP denotes Fig.
T10118 13605-13607 CD denotes 5c
T10119 13607-13608 -RRB- denotes )
T10120 13608-13609 . denotes .
T10121 13610-13612 PRP denotes We
T10122 13613-13617 RB denotes also
T10123 13618-13623 VBD denotes found
T10124 13624-13628 IN denotes that
T10125 13629-13633 CD denotes RPS3
T10126 13634-13643 JJ denotes knockdown
T10127 13644-13651 VBN denotes reduced
T10128 13652-13663 JJ denotes TNF-induced
T10129 13664-13674 NN denotes expression
T10130 13675-13677 IN denotes of
T10131 13678-13680 DT denotes an
T10132 13681-13683 NNP denotes Ig
T10133 13684-13693 NNP denotes κB-driven
T10134 13694-13704 VBD denotes luciferase
T10135 13705-13715 CD denotes construct6
T10136 13716-13717 -LRB- denotes (
T10137 13717-13721 NNP denotes Fig.
T10138 13722-13724 CD denotes 5d
T10139 13724-13725 -RRB- denotes )
T10140 13725-13726 . denotes .
T10141 13727-13730 DT denotes The
T10142 13731-13739 VBN denotes impaired
T10143 13740-13750 NN denotes luciferase
T10144 13751-13757 NN denotes signal
T10145 13758-13764 VBN denotes caused
T10146 13765-13767 IN denotes by
T10147 13768-13772 CD denotes RPS3
T10148 13773-13783 NN denotes deficiency
T10149 13784-13787 VBD denotes was
T10150 13788-13798 RB denotes completely
T10151 13799-13807 VBN denotes restored
T10152 13808-13810 IN denotes by
T10153 13811-13823 VBG denotes transfecting
T10154 13824-13833 JJ denotes wild-type
T10155 13833-13834 , denotes ,
T10156 13835-13838 CC denotes but
T10157 13839-13842 RB denotes not
T10158 13843-13845 IN denotes by
T10159 13846-13851 NNP denotes S209A
T10160 13852-13856 NNP denotes RPS3
T10161 13857-13858 -LRB- denotes (
T10162 13858-13862 NNP denotes Fig.
T10163 13863-13865 CD denotes 5d
T10164 13865-13866 -RRB- denotes )
T10165 13866-13867 , denotes ,
T10166 13868-13875 IN denotes despite
T10167 13876-13886 JJ denotes equivalent
T10168 13887-13897 NN denotes expression
T10169 13898-13899 -LRB- denotes (
T10170 13899-13903 NNP denotes Fig.
T10171 13904-13906 CD denotes 5c
T10172 13906-13907 -RRB- denotes )
T10173 13907-13908 . denotes .
T10174 13909-13917 RB denotes Moreover
T10175 13917-13918 , denotes ,
T10176 13919-13922 DT denotes the
T10177 13923-13930 NN denotes failure
T10178 13931-13933 IN denotes of
T10179 13934-13939 NNP denotes S209A
T10180 13940-13944 NNP denotes RPS3
T10181 13945-13947 TO denotes to
T10182 13948-13955 VB denotes restore
T10183 13956-13966 NN denotes luciferase
T10184 13967-13975 NN denotes activity
T10185 13976-13979 VBD denotes did
T10186 13980-13983 RB denotes not
T10187 13984-13990 VB denotes result
T10188 13991-13995 IN denotes from
T10189 13996-14005 JJ denotes defective
T10190 14006-14017 NN denotes translation
T10191 14018-14025 IN denotes because
T10192 14026-14029 DT denotes the
T10193 14030-14039 NN denotes transient
T10194 14040-14054 NN denotes overexpression
T10195 14055-14057 IN denotes of
T10196 14058-14063 JJ denotes green
T10197 14064-14075 JJ denotes fluorescent
T10198 14076-14083 NN denotes protein
T10199 14084-14085 -LRB- denotes (
T10200 14085-14088 NNP denotes GFP
T10201 14088-14089 -RRB- denotes )
T10202 14090-14093 VBD denotes was
T10203 14094-14104 JJ denotes comparable
T10204 14105-14107 IN denotes in
T10205 14108-14113 NNS denotes cells
T10206 14114-14126 VBN denotes complemented
T10207 14127-14131 IN denotes with
T10208 14132-14141 JJ denotes wild-type
T10209 14142-14144 CC denotes or
T10210 14145-14150 NNP denotes S029A
T10211 14151-14155 NNP denotes RPS3
T10212 14156-14157 -LRB- denotes (
T10213 14157-14170 NNP denotes Supplementary
T10214 14171-14175 NNP denotes Fig.
T10215 14176-14177 CD denotes 8
T10216 14177-14178 -RRB- denotes )
T10217 14178-14179 . denotes .
T10218 14180-14185 VBN denotes Taken
T10219 14186-14194 RB denotes together
T10220 14194-14195 , denotes ,
T10221 14196-14201 DT denotes these
T10222 14202-14206 NNS denotes data
T10223 14207-14214 VBP denotes suggest
T10224 14215-14219 IN denotes that
T10225 14220-14224 CD denotes RPS3
T10226 14225-14229 CD denotes S209
T10227 14230-14245 NN denotes phosphorylation
T10228 14246-14248 VBZ denotes is
T10229 14249-14257 JJ denotes critical
T10230 14258-14261 IN denotes for
T10231 14262-14267 JJ denotes NF-κB
T10232 14268-14276 NN denotes activity
T10233 14277-14286 VBG denotes involving
T10234 14287-14290 DT denotes the
T10235 14291-14300 JJ denotes canonical
T10236 14301-14303 NNP denotes Ig
T10237 14304-14306 NNP denotes κB
T10238 14307-14311 NN denotes site
T10239 14311-14312 . denotes .
T10240 14313-14315 PRP denotes We
T10241 14316-14320 JJ denotes next
T10242 14321-14325 VBN denotes used
T10243 14326-14335 NN denotes chromatin
T10244 14336-14355 NN denotes immunoprecipitation
T10245 14356-14358 TO denotes to
T10246 14359-14368 VB denotes determine
T10247 14369-14376 IN denotes whether
T10248 14377-14381 NNP denotes S209
T10249 14382-14397 NN denotes phosphorylation
T10250 14398-14405 VBZ denotes affects
T10251 14406-14410 CD denotes RPS3
T10252 14411-14414 CC denotes and
T10253 14415-14418 CD denotes p65
T10254 14419-14430 NN denotes recruitment
T10255 14431-14433 TO denotes to
T10256 14434-14442 JJ denotes specific
T10257 14443-14445 NN denotes κB
T10258 14446-14451 NNS denotes sites
T10259 14452-14454 IN denotes in
T10260 14455-14461 JJ denotes intact
T10261 14462-14471 NN denotes chromatin
T10262 14472-14478 IN denotes during
T10263 14479-14484 NNP denotes NF-κB
T10264 14485-14495 NN denotes activation
T10265 14495-14496 . denotes .
T10266 14497-14499 IN denotes In
T10267 14500-14504 CD denotes RPS3
T10268 14505-14514 JJ denotes knockdown
T10269 14515-14520 NNS denotes cells
T10270 14520-14521 , denotes ,
T10271 14522-14527 NNP denotes PMA+I
T10272 14528-14538 VBD denotes stimulated
T10273 14539-14542 DT denotes the
T10274 14543-14554 NN denotes recruitment
T10275 14555-14557 IN denotes of
T10276 14558-14569 RB denotes ectopically
T10277 14570-14579 VBN denotes expressed
T10278 14579-14580 , denotes ,
T10279 14581-14592 JJ denotes Flag-tagged
T10280 14593-14602 JJ denotes wild-type
T10281 14602-14603 , denotes ,
T10282 14604-14607 CC denotes but
T10283 14608-14611 RB denotes not
T10284 14612-14617 NNP denotes S209A
T10285 14618-14622 NNP denotes RPS3
T10286 14623-14625 TO denotes to
T10287 14626-14629 DT denotes the
T10288 14630-14632 NN denotes κB
T10289 14633-14638 NNS denotes sites
T10290 14639-14641 IN denotes of
T10291 14642-14645 DT denotes the
T10292 14646-14652 NNP denotes NFKBIA
T10293 14653-14656 CC denotes and
T10294 14657-14660 NNP denotes IL8
T10295 14661-14670 NNS denotes promoters
T10296 14671-14672 -LRB- denotes (
T10297 14672-14676 NNP denotes Fig.
T10298 14677-14679 CD denotes 5e
T10299 14679-14680 -RRB- denotes )
T10300 14680-14681 . denotes .
T10301 14682-14687 IN denotes While
T10302 14688-14698 VBG denotes expressing
T10303 14699-14703 NNP denotes RPS3
T10304 14704-14709 NNP denotes S209A
T10305 14710-14713 VBD denotes had
T10306 14714-14716 DT denotes no
T10307 14717-14723 NN denotes impact
T10308 14724-14726 IN denotes on
T10309 14727-14730 CD denotes p65
T10310 14731-14738 JJ denotes nuclear
T10311 14739-14752 NN denotes translocation
T10312 14752-14753 , denotes ,
T10313 14754-14756 PRP denotes it
T10314 14757-14770 RB denotes substantially
T10315 14771-14781 VBD denotes attenuated
T10316 14782-14785 CD denotes p65
T10317 14786-14797 NN denotes recruitment
T10318 14798-14799 -LRB- denotes (
T10319 14799-14803 NNP denotes Fig.
T10320 14804-14806 CD denotes 5e
T10321 14806-14807 -RRB- denotes )
T10322 14807-14808 . denotes .
T10323 14809-14819 JJ denotes Additional
T10324 14820-14831 NNS denotes experiments
T10325 14832-14840 VBD denotes revealed
T10326 14841-14845 IN denotes that
T10327 14846-14849 CD denotes p65
T10328 14850-14860 NN denotes attraction
T10329 14861-14863 TO denotes to
T10330 14864-14880 JJ denotes RPS3-independent
T10331 14881-14886 NN denotes NF-κB
T10332 14887-14893 NN denotes target
T10333 14894-14898 NN denotes gene
T10334 14899-14908 NNS denotes promoters
T10335 14909-14913 JJ denotes such
T10336 14914-14916 IN denotes as
T10337 14917-14921 NNP denotes CD25
T10338 14922-14925 VBD denotes was
T10339 14926-14935 VBN denotes increased
T10340 14936-14937 -LRB- denotes (
T10341 14937-14950 NNP denotes Supplementary
T10342 14951-14955 NNP denotes Fig.
T10343 14956-14957 CD denotes 9
T10344 14957-14958 -RRB- denotes )
T10345 14958-14959 , denotes ,
T10346 14960-14970 JJ denotes consistent
T10347 14971-14975 IN denotes with
T10348 14976-14979 PRP$ denotes our
T10349 14980-14988 JJ denotes previous
T10350 14989-15002 NNS denotes observations6
T10351 15002-15003 . denotes .
T10352 15004-15009 EX denotes There
T10353 15010-15013 VBD denotes was
T10354 15014-15016 DT denotes no
T10355 15017-15028 JJ denotes significant
T10356 15029-15038 NN denotes Flag-RPS3
T10357 15039-15041 CC denotes or
T10358 15042-15045 CD denotes p65
T10359 15046-15057 NN denotes recruitment
T10360 15058-15060 TO denotes to
T10361 15061-15065 NNP denotes ACTB
T10362 15066-15074 NN denotes promoter
T10363 15075-15082 VBG denotes lacking
T10364 15083-15085 NNP denotes κB
T10365 15086-15091 NNS denotes sites
T10366 15092-15093 -LRB- denotes (
T10367 15093-15097 NNP denotes Fig.
T10368 15098-15100 CD denotes 5e
T10369 15100-15101 -RRB- denotes )
T10370 15101-15102 , denotes ,
T10371 15103-15113 VBG denotes suggesting
T10372 15114-15117 DT denotes the
T10373 15118-15129 NN denotes recruitment
T10374 15130-15133 VBD denotes was
T10375 15134-15136 NNP denotes κB
T10376 15137-15150 JJ denotes site-specific
T10377 15150-15151 . denotes .
T10378 15152-15156 RB denotes Thus
T10379 15156-15157 , denotes ,
T10380 15158-15161 DT denotes the
T10381 15162-15173 NN denotes recruitment
T10382 15174-15176 IN denotes of
T10383 15177-15181 CD denotes RPS3
T10384 15182-15184 RB denotes as
T10385 15185-15189 RB denotes well
T10386 15190-15192 IN denotes as
T10387 15193-15196 DT denotes the
T10388 15197-15207 JJ denotes contingent
T10389 15208-15219 NN denotes recruitment
T10390 15220-15222 IN denotes of
T10391 15223-15226 CD denotes p65
T10392 15227-15229 TO denotes to
T10393 15230-15233 JJ denotes key
T10394 15234-15243 NNS denotes promoters
T10395 15244-15252 VBD denotes depended
T10396 15253-15255 IN denotes on
T10397 15256-15260 NNP denotes S209
T10398 15260-15261 . denotes .
T10399 15262-15273 NNP denotes Interleukin
T10400 15274-15275 CD denotes 8
T10401 15276-15277 -LRB- denotes (
T10402 15277-15281 NN denotes IL-8
T10403 15281-15282 -RRB- denotes )
T10404 15283-15292 NN denotes secretion
T10405 15293-15300 VBN denotes induced
T10406 15301-15303 IN denotes by
T10407 15304-15310 DT denotes either
T10408 15311-15312 NNP denotes T
T10409 15313-15317 NN denotes cell
T10410 15318-15326 NN denotes receptor
T10411 15327-15328 -LRB- denotes (
T10412 15328-15331 NNP denotes TCR
T10413 15331-15332 -RRB- denotes )
T10414 15333-15340 JJ denotes agonist
T10415 15341-15352 NN denotes stimulation
T10416 15353-15355 CC denotes or
T10417 15356-15361 NNP denotes PMA+I
T10418 15362-15365 VBD denotes was
T10419 15366-15375 VBN denotes decreased
T10420 15376-15378 IN denotes as
T10421 15379-15380 DT denotes a
T10422 15381-15392 NN denotes consequence
T10423 15393-15395 IN denotes of
T10424 15396-15403 JJ denotes reduced
T10425 15404-15412 NNS denotes RPS3/p65
T10426 15413-15424 NN denotes recruitment
T10427 15425-15427 TO denotes to
T10428 15428-15431 DT denotes the
T10429 15432-15435 NNP denotes IL8
T10430 15436-15438 NNP denotes κB
T10431 15439-15444 NNS denotes sites
T10432 15445-15447 IN denotes in
T10433 15448-15451 DT denotes the
T10434 15452-15460 NN denotes presence
T10435 15461-15463 IN denotes of
T10436 15464-15469 CD denotes S209A
T10437 15470-15476 JJ denotes mutant
T10438 15477-15485 VBN denotes compared
T10439 15486-15488 TO denotes to
T10440 15489-15498 JJ denotes wild-type
T10441 15499-15503 NNP denotes RPS3
T10442 15504-15505 -LRB- denotes (
T10443 15505-15518 NNP denotes Supplementary
T10444 15519-15523 NNP denotes Fig.
T10445 15524-15526 CD denotes 10
T10446 15526-15527 -RRB- denotes )
T10447 15527-15528 . denotes .
T10448 15529-15536 RB denotes However
T10449 15536-15537 , denotes ,
T10450 15538-15542 NN denotes cell
T10451 15543-15550 NN denotes surface
T10452 15551-15555 NNP denotes CD25
T10453 15556-15566 NN denotes expression
T10454 15567-15570 VBD denotes was
T10455 15571-15581 JJ denotes comparable
T10456 15582-15589 IN denotes between
T10457 15590-15593 DT denotes the
T10458 15594-15603 JJ denotes wild-type
T10459 15604-15607 CC denotes and
T10460 15608-15613 NNP denotes S209A
T10461 15614-15618 NNP denotes RPS3
T10462 15619-15630 VBD denotes transfected
T10463 15631-15636 NNS denotes cells
T10464 15637-15638 -LRB- denotes (
T10465 15638-15651 NNP denotes Supplementary
T10466 15652-15656 NNP denotes Fig.
T10467 15657-15659 CD denotes 11
T10468 15659-15660 -RRB- denotes )
T10469 15660-15661 . denotes .
T10470 15662-15671 RB denotes Therefore
T10471 15671-15672 , denotes ,
T10472 15673-15677 NNP denotes RPS3
T10473 15678-15682 NNP denotes S209
T10474 15683-15698 NN denotes phosphorylation
T10475 15699-15701 IN denotes by
T10476 15702-15706 NNP denotes IKKβ
T10477 15707-15709 VBZ denotes is
T10478 15710-15720 RB denotes apparently
T10479 15721-15729 VBN denotes required
T10480 15730-15733 IN denotes for
T10481 15734-15738 NNP denotes RPS3
T10482 15739-15741 IN denotes in
T10483 15742-15751 VBG denotes directing
T10484 15752-15757 NN denotes NF-κB
T10485 15758-15760 TO denotes to
T10486 15761-15762 DT denotes a
T10487 15763-15771 JJ denotes specific
T10488 15772-15778 NN denotes subset
T10489 15779-15781 IN denotes of
T10490 15782-15788 NN denotes target
T10491 15789-15794 NNS denotes genes
T10492 15794-15795 . denotes .
T12437 15797-15802 CD denotes NleH1
T12438 15803-15811 NNS denotes inhibits
T12439 15812-15816 JJ denotes RPS3
T12440 15817-15832 NN denotes phosphorylation
T12441 15833-15835 IN denotes in
T12442 15836-15841 NN denotes vitro
T12443 15842-15846 NNP denotes EHEC
T12444 15847-15856 NNS denotes pathogens
T12445 15857-15860 VBP denotes are
T12446 15861-15870 JJ denotes important
T12447 15871-15880 JJ denotes causative
T12448 15881-15887 NNS denotes agents
T12449 15888-15890 IN denotes of
T12450 15891-15895 DT denotes both
T12451 15896-15905 JJ denotes foodborne
T12452 15906-15913 NN denotes disease
T12453 15914-15917 CC denotes and
T12454 15918-15927 JJ denotes pediatric
T12455 15928-15933 JJ denotes renal
T12456 15934-15943 NN denotes failure31
T12457 15943-15944 . denotes .
T12458 15945-15949 NNP denotes EHEC
T12459 15950-15957 VB denotes utilize
T12460 15958-15962 CD denotes T3SS
T12461 15963-15965 TO denotes to
T12462 15966-15972 VB denotes inject
T12463 15973-15981 NN denotes effector
T12464 15982-15990 NNS denotes proteins
T12465 15991-15999 RB denotes directly
T12466 16000-16004 IN denotes into
T12467 16005-16015 JJ denotes intestinal
T12468 16016-16026 JJ denotes epithelial
T12469 16027-16034 NN denotes cells32
T12470 16034-16035 , denotes ,
T12471 16036-16037 DT denotes a
T12472 16038-16044 NN denotes subset
T12473 16045-16047 IN denotes of
T12474 16048-16053 WDT denotes which
T12475 16054-16061 VBP denotes inhibit
T12476 16062-16077 JJ denotes NF-κB-dependent
T12477 16078-16084 NN denotes innate
T12478 16085-16095 CD denotes responses9
T12479 16095-16096 , denotes ,
T12480 16097-16102 CD denotes 33-38
T12481 16102-16103 . denotes .
T12482 16104-16107 DT denotes The
T12483 16108-16110 NNP denotes E.
T12484 16111-16115 NNS denotes coli
T12485 16116-16120 NNP denotes O157
T12486 16120-16121 : denotes :
T12487 16121-16123 NNP denotes H7
T12488 16124-16130 NNP denotes EDL933
T12489 16131-16139 NN denotes effector
T12490 16140-16147 NN denotes protein
T12491 16148-16153 NNP denotes NleH1
T12492 16154-16159 VBZ denotes binds
T12493 16160-16162 TO denotes to
T12494 16163-16166 CC denotes and
T12495 16167-16177 VBZ denotes attenuates
T12496 16178-16182 NNP denotes RPS3
T12497 16183-16190 JJ denotes nuclear
T12498 16191-16204 NN denotes translocation
T12499 16204-16205 , denotes ,
T12500 16206-16210 RB denotes thus
T12501 16211-16220 VBG denotes impairing
T12502 16221-16235 JJ denotes RPS3-dependent
T12503 16236-16241 NNP denotes NF-κB
T12504 16242-16252 CD denotes signaling9
T12505 16252-16253 . denotes .
T12506 16254-16256 PRP denotes We
T12507 16257-16266 RB denotes therefore
T12508 16267-16279 VBD denotes hypothesized
T12509 16280-16284 IN denotes that
T12510 16285-16290 NNP denotes NleH1
T12511 16291-16294 MD denotes may
T12512 16295-16303 VB denotes function
T12513 16304-16306 IN denotes by
T12514 16307-16317 VBG denotes inhibiting
T12515 16318-16322 NNP denotes RPS3
T12516 16323-16327 NNP denotes S209
T12517 16328-16343 NN denotes phosphorylation
T12518 16343-16344 . denotes .
T12519 16345-16347 IN denotes As
T12520 16348-16356 VBN denotes expected
T12521 16356-16357 , denotes ,
T12522 16358-16370 VBG denotes transfecting
T12523 16371-16381 VBG denotes increasing
T12524 16382-16389 NNS denotes amounts
T12525 16390-16392 IN denotes of
T12526 16393-16401 JJ denotes NleH1-HA
T12527 16402-16409 JJ denotes plasmid
T12528 16410-16417 VBN denotes blocked
T12529 16418-16430 JJ denotes TNFα-induced
T12530 16431-16436 NN denotes NF-κB
T12531 16437-16447 NN denotes activation
T12532 16448-16450 IN denotes in
T12533 16451-16452 DT denotes a
T12534 16453-16467 JJ denotes dose-dependent
T12535 16468-16474 NN denotes manner
T12536 16475-16476 -LRB- denotes (
T12537 16476-16480 NNP denotes Fig.
T12538 16481-16485 JJ denotes 6a-b
T12539 16485-16486 -RRB- denotes )
T12540 16486-16487 CD denotes 9
T12541 16487-16488 . denotes .
T12542 16489-16499 RB denotes Remarkably
T12543 16499-16500 , denotes ,
T12544 16501-16506 NNP denotes NleH1
T12545 16507-16514 VBD denotes reduced
T12546 16515-16519 DT denotes both
T12547 16520-16531 JJ denotes TNF-induced
T12548 16531-16532 , denotes ,
T12549 16533-16535 RB denotes as
T12550 16536-16540 RB denotes well
T12551 16541-16543 IN denotes as
T12552 16544-16549 JJ denotes basal
T12553 16550-16554 JJ denotes RPS3
T12554 16555-16570 NN denotes phosphorylation
T12555 16571-16573 TO denotes to
T12556 16574-16581 RB denotes roughly
T12557 16582-16584 CD denotes 20
T12558 16584-16585 NN denotes %
T12559 16586-16588 IN denotes of
T12560 16589-16596 NN denotes vehicle
T12561 16597-16604 NN denotes control
T12562 16605-16606 -LRB- denotes (
T12563 16606-16610 NNP denotes Fig.
T12564 16611-16613 CD denotes 6c
T12565 16613-16614 -RRB- denotes )
T12566 16614-16615 . denotes .
T12567 16616-16626 VBG denotes Expressing
T12568 16627-16632 NN denotes NleH1
T12569 16633-16637 VBZ denotes does
T12570 16638-16641 RB denotes not
T12571 16642-16651 VB denotes interfere
T12572 16652-16656 IN denotes with
T12573 16657-16663 DT denotes either
T12574 16664-16675 JJ denotes TNF-induced
T12575 16676-16679 NNP denotes IKK
T12576 16680-16690 NN denotes activation
T12577 16691-16693 CC denotes or
T12578 16694-16698 NN denotes IκBα
T12579 16699-16710 NN denotes degradation
T12580 16710-16711 , denotes ,
T12581 16712-16722 JJ denotes consistent
T12582 16723-16727 IN denotes with
T12583 16728-16731 DT denotes the
T12584 16732-16736 NN denotes lack
T12585 16737-16739 IN denotes of
T12586 16740-16745 JJ denotes NleH1
T12587 16746-16752 NN denotes impact
T12588 16753-16755 IN denotes on
T12589 16756-16759 CD denotes p65
T12590 16760-16767 JJ denotes nuclear
T12591 16768-16782 NNS denotes translocation9
T12592 16783-16784 -LRB- denotes (
T12593 16784-16788 NNP denotes Fig.
T12594 16789-16791 CD denotes 6c
T12595 16791-16792 -RRB- denotes )
T12596 16792-16793 . denotes .
T12597 16794-16796 TO denotes To
T12598 16797-16806 VB denotes determine
T12599 16807-16809 IN denotes if
T12600 16810-16815 JJ denotes NleH1
T12601 16816-16824 NNS denotes inhibits
T12602 16825-16829 JJ denotes RPS3
T12603 16830-16845 NN denotes phosphorylation
T12604 16845-16846 , denotes ,
T12605 16847-16849 PRP denotes we
T12606 16850-16858 VBD denotes infected
T12607 16859-16863 NNP denotes HeLa
T12608 16864-16869 NNS denotes cells
T12609 16870-16874 IN denotes with
T12610 16875-16877 NNP denotes E.
T12611 16878-16882 NNS denotes coli
T12612 16883-16887 NNP denotes O157
T12613 16887-16888 : denotes :
T12614 16888-16890 NNP denotes H7
T12615 16891-16898 NNS denotes strains
T12616 16899-16909 VBG denotes possessing
T12617 16910-16912 CC denotes or
T12618 16913-16920 VBG denotes lacking
T12619 16921-16927 CC denotes either
T12620 16928-16933 NNP denotes nleH1
T12621 16934-16935 -LRB- denotes (
T12622 16935-16941 NNP denotes ΔnleH1
T12623 16941-16942 -RRB- denotes )
T12624 16943-16945 CC denotes or
T12625 16946-16950 IN denotes with
T12626 16951-16952 DT denotes a
T12627 16953-16959 NN denotes strain
T12628 16960-16967 VBG denotes lacking
T12629 16968-16969 DT denotes a
T12630 16970-16980 JJ denotes functional
T12631 16981-16985 CD denotes T3SS
T12632 16986-16992 JJ denotes unable
T12633 16993-16995 TO denotes to
T12634 16996-17002 VB denotes inject
T12635 17003-17008 NNP denotes NleH1
T12636 17009-17013 IN denotes into
T12637 17014-17023 JJ denotes mammalian
T12638 17024-17029 NNS denotes cells
T12639 17030-17031 -LRB- denotes (
T12640 17031-17036 NNP denotes ΔescN
T12641 17036-17037 -RRB- denotes )
T12642 17037-17038 . denotes .
T12643 17039-17041 IN denotes In
T12644 17042-17052 JJ denotes uninfected
T12645 17053-17058 NNS denotes cells
T12646 17058-17059 , denotes ,
T12647 17060-17073 JJ denotes TNF-treatment
T12648 17074-17084 VBD denotes stimulated
T12649 17085-17086 DT denotes a
T12650 17087-17088 NN denotes
T12651 17088-17094 JJ denotes 7-fold
T12652 17095-17103 NN denotes increase
T12653 17104-17106 IN denotes in
T12654 17107-17111 NNP denotes RPS3
T12655 17112-17116 NNP denotes S209
T12656 17117-17132 NN denotes phosphorylation
T12657 17132-17133 , denotes ,
T12658 17134-17141 VBG denotes peaking
T12659 17142-17144 IN denotes at
T12660 17145-17147 CD denotes 30
T12661 17148-17155 NNS denotes minutes
T12662 17156-17157 -LRB- denotes (
T12663 17157-17161 NNP denotes Fig.
T12664 17162-17164 CD denotes 6d
T12665 17164-17165 -RRB- denotes )
T12666 17165-17166 . denotes .
T12667 17167-17169 IN denotes By
T12668 17170-17178 NN denotes contrast
T12669 17178-17179 , denotes ,
T12670 17180-17184 NNP denotes RPS3
T12671 17185-17189 NNP denotes S209
T12672 17190-17205 NN denotes phosphorylation
T12673 17206-17209 VBD denotes was
T12674 17210-17223 RB denotes substantially
T12675 17224-17232 VBN denotes impaired
T12676 17233-17235 IN denotes in
T12677 17236-17241 NNS denotes cells
T12678 17242-17250 VBN denotes infected
T12679 17251-17255 IN denotes with
T12680 17256-17265 JJ denotes wild-type
T12681 17266-17268 NNP denotes E.
T12682 17269-17273 NNS denotes coli
T12683 17274-17278 NNP denotes O157
T12684 17278-17279 : denotes :
T12685 17279-17281 NNP denotes H7
T12686 17282-17283 -LRB- denotes (
T12687 17283-17287 NNP denotes Fig.
T12688 17288-17290 CD denotes 6d
T12689 17290-17291 -RRB- denotes )
T12690 17291-17292 . denotes .
T12691 17293-17300 RB denotes However
T12692 17300-17301 , denotes ,
T12693 17302-17313 JJ denotes TNF-induced
T12694 17314-17318 NNP denotes RPS3
T12695 17319-17323 NNP denotes S209
T12696 17324-17339 NN denotes phosphorylation
T12697 17340-17343 VBD denotes was
T12698 17344-17354 VBN denotes unimpaired
T12699 17355-17357 IN denotes in
T12700 17358-17363 NNS denotes cells
T12701 17364-17372 VBN denotes infected
T12702 17373-17377 IN denotes with
T12703 17378-17384 DT denotes either
T12704 17385-17391 NNP denotes ΔnleH1
T12705 17392-17394 CC denotes or
T12706 17395-17400 NNP denotes ΔescN
T12707 17401-17402 -LRB- denotes (
T12708 17402-17406 NNP denotes Fig.
T12709 17407-17409 CD denotes 6d
T12710 17409-17410 -RRB- denotes )
T12711 17410-17411 . denotes .
T12712 17412-17414 PRP denotes We
T12713 17415-17421 VBD denotes showed
T12714 17422-17432 RB denotes previously
T12715 17433-17437 IN denotes that
T12716 17438-17447 JJ denotes wild-type
T12717 17447-17448 , denotes ,
T12718 17449-17452 CC denotes but
T12719 17453-17456 RB denotes not
T12720 17457-17463 JJ denotes ΔnleH1
T12721 17464-17466 CC denotes or
T12722 17467-17472 NNP denotes ΔescN
T12723 17473-17475 NNP denotes E.
T12724 17476-17480 NNS denotes coli
T12725 17481-17485 NNP denotes O157
T12726 17485-17486 : denotes :
T12727 17486-17488 NNP denotes H7
T12728 17489-17502 RB denotes significantly
T12729 17503-17513 VBD denotes attenuated
T12730 17514-17525 JJ denotes TNF-induced
T12731 17526-17530 JJ denotes RPS3
T12732 17531-17538 JJ denotes nuclear
T12733 17539-17553 NNS denotes translocation9
T12734 17553-17554 . denotes .
T12735 17555-17558 DT denotes The
T12736 17559-17567 NN denotes parallel
T12737 17568-17575 IN denotes between
T12738 17576-17580 CD denotes RPS3
T12739 17581-17596 NN denotes phosphorylation
T12740 17597-17600 CC denotes and
T12741 17601-17604 PRP$ denotes its
T12742 17605-17612 JJ denotes nuclear
T12743 17613-17626 NN denotes translocation
T12744 17627-17633 IN denotes during
T12745 17634-17636 NNP denotes E.
T12746 17637-17641 NNS denotes coli
T12747 17642-17651 NN denotes infection
T12748 17652-17660 VBZ denotes provides
T12749 17661-17669 NN denotes evidence
T12750 17670-17672 IN denotes in
T12751 17673-17676 DT denotes the
T12752 17677-17684 NN denotes context
T12753 17685-17687 IN denotes of
T12754 17688-17690 DT denotes an
T12755 17691-17706 JJ denotes NF-κB-dependent
T12756 17707-17714 NN denotes disease
T12757 17715-17722 NN denotes process
T12758 17723-17727 WDT denotes that
T12759 17728-17732 NNP denotes RPS3
T12760 17733-17737 NNP denotes S209
T12761 17738-17753 NN denotes phosphorylation
T12762 17754-17756 VBZ denotes is
T12763 17757-17766 JJ denotes important
T12764 17767-17770 IN denotes for
T12765 17771-17778 JJ denotes nuclear
T12766 17779-17792 NN denotes translocation
T12767 17792-17793 . denotes .
T12768 17794-17797 PRP$ denotes Our
T12769 17798-17807 NN denotes discovery
T12770 17808-17812 IN denotes that
T12771 17813-17818 NNP denotes NleH1
T12772 17819-17827 VBZ denotes inhibits
T12773 17828-17832 NNP denotes RPS3
T12774 17833-17837 NNP denotes S209
T12775 17838-17853 NN denotes phosphorylation
T12776 17854-17863 VBD denotes suggested
T12777 17864-17868 IN denotes that
T12778 17869-17871 PRP denotes it
T12779 17872-17878 MD denotes should
T12780 17879-17883 RB denotes also
T12781 17884-17890 NNS denotes blocks
T12782 17891-17905 JJ denotes RPS3-dependent
T12783 17906-17911 NN denotes NF-κB
T12784 17912-17918 NN denotes target
T12785 17919-17923 NN denotes gene
T12786 17924-17937 NN denotes transcription
T12787 17938-17939 -LRB- denotes (
T12788 17939-17943 FW denotes e.g.
T12789 17944-17947 FW denotes IL8
T12790 17947-17948 , denotes ,
T12791 17949-17955 NNP denotes NFKBIA
T12792 17955-17956 , denotes ,
T12793 17957-17960 CC denotes and
T12794 17961-17968 CD denotes TNFAIP3
T12795 17968-17969 -RRB- denotes )
T12796 17969-17970 . denotes .
T12797 17971-17977 RB denotes Indeed
T12798 17977-17978 , denotes ,
T12799 17979-17984 DT denotes these
T12800 17985-17990 NNS denotes genes
T12801 17991-17995 VBD denotes were
T12802 17996-18000 RB denotes only
T12803 18001-18009 RB denotes modestly
T12804 18010-18021 VBN denotes upregulated
T12805 18022-18024 IN denotes in
T12806 18025-18030 NNS denotes cells
T12807 18031-18039 VBN denotes infected
T12808 18040-18044 IN denotes with
T12809 18045-18054 JJ denotes wild-type
T12810 18055-18057 NNP denotes E.
T12811 18058-18062 NNS denotes coli
T12812 18063-18067 NNP denotes O157
T12813 18067-18068 : denotes :
T12814 18068-18070 NNP denotes H7
T12815 18070-18071 , denotes ,
T12816 18072-18075 CC denotes but
T12817 18076-18089 RB denotes significantly
T12818 18090-18097 VBD denotes induced
T12819 18098-18100 IN denotes in
T12820 18101-18106 NNS denotes cells
T12821 18107-18115 VBN denotes infected
T12822 18116-18120 IN denotes with
T12823 18121-18127 DT denotes either
T12824 18128-18134 NNP denotes ΔnleH1
T12825 18135-18137 CC denotes or
T12826 18138-18143 NNP denotes ΔescN
T12827 18144-18151 NNS denotes strains
T12828 18152-18153 -LRB- denotes (
T12829 18153-18157 NNP denotes Fig.
T12830 18158-18160 CD denotes 6e
T12831 18160-18161 -RRB- denotes )
T12832 18161-18162 . denotes .
T12833 18163-18165 IN denotes In
T12834 18166-18174 NN denotes contrast
T12835 18174-18175 , denotes ,
T12836 18176-18184 VBG denotes deleting
T12837 18185-18190 NNP denotes nleH1
T12838 18191-18194 VBD denotes had
T12839 18195-18197 DT denotes no
T12840 18198-18204 NN denotes impact
T12841 18205-18207 IN denotes on
T12842 18208-18211 DT denotes the
T12843 18212-18222 NN denotes expression
T12844 18223-18225 IN denotes of
T12845 18226-18242 JJ denotes RPS3-independent
T12846 18243-18248 NNS denotes genes
T12847 18248-18249 , denotes ,
T12848 18250-18259 VBG denotes including
T12849 18260-18264 NNP denotes CD25
T12850 18265-18268 CC denotes and
T12851 18269-18277 NNP denotes TNFSF13B
T12852 18278-18279 -LRB- denotes (
T12853 18279-18292 NNP denotes Supplementary
T12854 18293-18297 NNP denotes Fig.
T12855 18298-18300 CD denotes 12
T12856 18300-18301 -RRB- denotes )
T12857 18301-18302 . denotes .
T12858 18303-18311 RB denotes Together
T12859 18312-18317 DT denotes these
T12860 18318-18325 NNS denotes results
T12861 18326-18337 VBP denotes demonstrate
T12862 18338-18342 IN denotes that
T12863 18343-18348 JJ denotes NleH1
T12864 18349-18361 RB denotes specifically
T12865 18362-18370 VBZ denotes inhibits
T12866 18371-18374 DT denotes the
T12867 18375-18385 JJ denotes protective
T12868 18386-18392 JJ denotes immune
T12869 18393-18401 NN denotes response
T12870 18402-18404 IN denotes by
T12871 18405-18413 RB denotes directly
T12872 18414-18422 VBG denotes blocking
T12873 18423-18427 NNP denotes RPS3
T12874 18428-18432 NNP denotes S209
T12875 18433-18448 NN denotes phosphorylation
T12876 18449-18452 CC denotes and
T12877 18453-18460 RB denotes thereby
T12878 18461-18470 VBG denotes impairing
T12879 18471-18479 JJ denotes critical
T12880 18480-18494 JJ denotes RPS3-dependent
T12881 18495-18500 NN denotes NF-κB
T12882 18501-18507 NN denotes target
T12883 18508-18513 NNS denotes genes
T12884 18513-18514 . denotes .
T13949 18516-18521 JJ denotes NleH1
T13950 18522-18530 NNS denotes inhibits
T13951 18531-18535 NNP denotes RPS3
T13952 18536-18540 NNP denotes S209
T13953 18541-18556 NN denotes phosphorylation
T13954 18557-18559 IN denotes in
T13955 18560-18564 NN denotes vivo
T13956 18565-18567 PRP denotes We
T13957 18568-18578 RB denotes previously
T13958 18579-18587 VBD denotes utilized
T13959 18588-18589 DT denotes a
T13960 18590-18601 JJ denotes gnotobiotic
T13961 18602-18608 NN denotes piglet
T13962 18609-18618 NN denotes infection
T13963 18619-18624 NN denotes model
T13964 18625-18627 TO denotes to
T13965 18628-18637 VB denotes determine
T13966 18638-18642 DT denotes that
T13967 18643-18650 NNS denotes piglets
T13968 18651-18659 VBN denotes infected
T13969 18660-18664 IN denotes with
T13970 18665-18671 JJ denotes ΔnleH1
T13971 18672-18678 JJ denotes mutant
T13972 18679-18683 VBD denotes died
T13973 18684-18688 RBR denotes more
T13974 18689-18696 RB denotes rapidly
T13975 18697-18701 IN denotes than
T13976 18702-18707 DT denotes those
T13977 18708-18716 VBN denotes infected
T13978 18717-18721 IN denotes with
T13979 18722-18731 JJ denotes wild-type
T13980 18732-18734 NNP denotes E.
T13981 18735-18739 NNS denotes coli
T13982 18740-18744 NNP denotes O157
T13983 18744-18745 : denotes :
T13984 18745-18747 NNP denotes H7
T13985 18747-18748 . denotes .
T13986 18749-18756 NNS denotes Piglets
T13987 18757-18765 VBN denotes infected
T13988 18766-18770 IN denotes with
T13989 18771-18777 NNP denotes ΔnleH1
T13990 18778-18787 VBD denotes displayed
T13991 18788-18796 JJ denotes clinical
T13992 18797-18804 NN denotes disease
T13993 18805-18815 JJ denotes consistent
T13994 18816-18820 IN denotes with
T13995 18821-18822 DT denotes a
T13996 18823-18829 JJ denotes robust
T13997 18830-18842 JJ denotes inflammatory
T13998 18843-18851 NN denotes response
T13999 18851-18852 , denotes ,
T14000 18853-18856 CC denotes but
T14001 18857-18861 IN denotes with
T14002 18862-18869 JJ denotes reduced
T14003 18870-18879 JJ denotes bacterial
T14004 18880-18892 NN denotes colonization
T14005 18893-18896 CC denotes and
T14006 18897-18903 JJ denotes little
T14007 18904-18913 NN denotes diarrhea9
T14008 18913-18914 . denotes .
T14009 18915-18920 IN denotes While
T14010 18921-18930 RB denotes seemingly
T14011 18931-18942 JJ denotes paradoxical
T14012 18942-18943 , denotes ,
T14013 18944-18949 VBN denotes based
T14014 18950-18952 IN denotes on
T14015 18953-18956 PRP$ denotes our
T14016 18957-18961 NN denotes cell
T14017 18962-18969 NN denotes culture
T14018 18970-18974 NNS denotes data
T14019 18975-18976 -LRB- denotes (
T14020 18976-18980 NNP denotes Fig.
T14021 18981-18983 CD denotes 6d
T14022 18983-18984 -RRB- denotes )
T14023 18984-18985 , denotes ,
T14024 18986-18988 PRP denotes we
T14025 18989-19001 VBD denotes hypothesized
T14026 19002-19006 IN denotes that
T14027 19007-19012 NNP denotes NleH1
T14028 19013-19020 VBD denotes blocked
T14029 19021-19025 CD denotes RPS3
T14030 19026-19030 CD denotes S209
T14031 19031-19046 NN denotes phosphorylation
T14032 19047-19049 IN denotes in
T14033 19050-19054 NN denotes vivo
T14034 19054-19055 , denotes ,
T14035 19056-19063 RB denotes thereby
T14036 19064-19074 VBG denotes preventing
T14037 19075-19079 JJ denotes RPS3
T14038 19080-19087 JJ denotes nuclear
T14039 19088-19101 NN denotes translocation
T14040 19102-19104 IN denotes in
T14041 19105-19113 JJ denotes infected
T14042 19114-19121 NNS denotes piglets
T14043 19121-19122 . denotes .
T14044 19123-19125 PRP denotes We
T14045 19126-19134 VBD denotes isolated
T14046 19135-19141 NN denotes piglet
T14047 19142-19148 NNS denotes colons
T14048 19149-19151 IN denotes at
T14049 19152-19160 NN denotes necropsy
T14050 19160-19161 , denotes ,
T14051 19162-19165 CC denotes and
T14052 19166-19175 VBD denotes subjected
T14053 19176-19180 PRP denotes them
T14054 19181-19183 TO denotes to
T14055 19184-19204 NN denotes immunohistochemistry
T14056 19205-19210 VBG denotes using
T14057 19211-19214 PRP$ denotes our
T14058 19215-19227 JJ denotes phospho-RPS3
T14059 19228-19236 NN denotes antibody
T14060 19236-19237 . denotes .
T14061 19238-19248 JJ denotes Consistent
T14062 19249-19253 IN denotes with
T14063 19254-19256 IN denotes in
T14064 19257-19262 NN denotes vitro
T14065 19263-19267 NNS denotes data
T14066 19267-19268 , denotes ,
T14067 19269-19276 NNS denotes piglets
T14068 19277-19285 VBN denotes infected
T14069 19286-19290 IN denotes with
T14070 19291-19300 JJ denotes wild-type
T14071 19301-19303 NNP denotes E.
T14072 19304-19308 NNS denotes coli
T14073 19309-19313 NNP denotes O157
T14074 19313-19314 : denotes :
T14075 19314-19316 NNP denotes H7
T14076 19317-19326 VBD denotes exhibited
T14077 19327-19334 NN denotes diffuse
T14078 19335-19338 CC denotes and
T14079 19339-19342 JJ denotes low
T14080 19343-19352 NN denotes intensity
T14081 19353-19365 NN denotes phospho-RPS3
T14082 19366-19374 NN denotes staining
T14083 19374-19375 , denotes ,
T14084 19376-19383 IN denotes whereas
T14085 19384-19386 IN denotes in
T14086 19387-19394 NNS denotes piglets
T14087 19395-19403 VBN denotes infected
T14088 19404-19408 IN denotes with
T14089 19409-19415 JJ denotes ΔnleH1
T14090 19416-19422 JJ denotes mutant
T14091 19422-19423 , denotes ,
T14092 19424-19436 JJ denotes phospho-RPS3
T14093 19437-19447 NN denotes expression
T14094 19448-19451 VBD denotes was
T14095 19452-19458 JJ denotes florid
T14096 19459-19462 CC denotes and
T14097 19463-19470 JJ denotes intense
T14098 19471-19472 -LRB- denotes (
T14099 19472-19476 NNP denotes Fig.
T14100 19477-19479 CD denotes 6f
T14101 19479-19480 -RRB- denotes )
T14102 19480-19481 . denotes .
T14103 19482-19487 DT denotes These
T14104 19488-19492 NNS denotes data
T14105 19493-19504 VBP denotes demonstrate
T14106 19505-19509 IN denotes that
T14107 19510-19515 JJ denotes NleH1
T14108 19516-19524 NNS denotes inhibits
T14109 19525-19529 NNP denotes RPS3
T14110 19530-19534 NNP denotes S209
T14111 19535-19550 NN denotes phosphorylation
T14112 19551-19555 DT denotes both
T14113 19556-19558 IN denotes in
T14114 19559-19564 NN denotes vitro
T14115 19565-19568 CC denotes and
T14116 19569-19571 IN denotes in
T14117 19572-19576 NN denotes vivo
T14118 19576-19577 , denotes ,
T14119 19578-19583 WDT denotes which
T14120 19584-19589 MD denotes might
T14121 19590-19597 VB denotes benefit
T14122 19598-19601 DT denotes the
T14123 19602-19611 NN denotes bacterium
T14124 19612-19614 IN denotes in
T14125 19615-19627 NN denotes colonization
T14126 19628-19631 CC denotes and
T14127 19632-19644 NN denotes transmission
T14128 19644-19645 . denotes .
T15728 19647-19652 JJ denotes NleH1
T15729 19653-19659 VBZ denotes steers
T15730 19660-19663 DT denotes the
T15731 19664-19668 NNP denotes IKKβ
T15732 19669-19678 VB denotes substrate
T15733 19679-19692 NNS denotes specificities
T15734 19693-19698 NNP denotes NleH1
T15735 19699-19701 VBZ denotes is
T15736 19702-19704 DT denotes an
T15737 19705-19723 JJ denotes autophosphorylated
T15738 19724-19740 JJ denotes serine-threonine
T15739 19741-19747 NN denotes kinase
T15740 19747-19748 , denotes ,
T15741 19749-19754 WDT denotes which
T15742 19755-19762 VBZ denotes depends
T15743 19763-19765 IN denotes on
T15744 19766-19769 DT denotes the
T15745 19770-19776 NN denotes lysine
T15746 19777-19780 CD denotes 159
T15747 19781-19782 -LRB- denotes (
T15748 19782-19786 NNP denotes K159
T15749 19786-19787 -RRB- denotes )
T15750 19787-19788 CD denotes 9
T15751 19788-19789 . denotes .
T15752 19790-19792 TO denotes To
T15753 19793-19800 VB denotes explore
T15754 19801-19804 DT denotes the
T15755 19805-19814 NN denotes mechanism
T15756 19815-19817 IN denotes by
T15757 19818-19823 WDT denotes which
T15758 19824-19829 NNP denotes NleH1
T15759 19830-19838 VBZ denotes inhibits
T15760 19839-19843 NNP denotes RPS3
T15761 19844-19848 NNP denotes S209
T15762 19849-19864 NN denotes phosphorylation
T15763 19864-19865 , denotes ,
T15764 19866-19868 PRP denotes we
T15765 19869-19874 RB denotes first
T15766 19875-19884 VBD denotes performed
T15767 19885-19887 DT denotes an
T15768 19888-19890 IN denotes in
T15769 19891-19896 NN denotes vitro
T15770 19897-19903 NN denotes kinase
T15771 19904-19909 NN denotes assay
T15772 19910-19914 IN denotes with
T15773 19915-19923 JJ denotes purified
T15774 19924-19933 JJ denotes wild-type
T15775 19934-19943 NN denotes His-NleH1
T15776 19944-19951 NN denotes protein
T15777 19952-19955 CC denotes and
T15778 19956-19957 DT denotes a
T15779 19958-19964 JJ denotes mutant
T15780 19965-19974 NN denotes His-NleH1
T15781 19975-19976 -LRB- denotes (
T15782 19976-19981 NNP denotes K159A
T15783 19981-19982 -RRB- denotes )
T15784 19983-19990 NN denotes protein
T15785 19990-19991 , denotes ,
T15786 19992-20002 VBG denotes confirming
T15787 20003-20007 IN denotes that
T15788 20008-20013 NNP denotes NleH1
T15789 20014-20016 VBZ denotes is
T15790 20017-20035 VBN denotes autophosphorylated
T15791 20036-20039 CC denotes and
T15792 20040-20043 DT denotes the
T15793 20044-20049 NNP denotes K159A
T15794 20050-20052 VBZ denotes is
T15795 20053-20055 DT denotes an
T15796 20056-20061 JJ denotes NleH1
T15797 20062-20073 NN denotes kinase-dead
T15798 20074-20080 JJ denotes mutant
T15799 20081-20082 -LRB- denotes (
T15800 20082-20086 NNP denotes Fig.
T15801 20087-20089 CD denotes 7a
T15802 20089-20090 -RRB- denotes )
T15803 20090-20091 . denotes .
T15804 20092-20094 TO denotes To
T15805 20095-20102 VB denotes examine
T15806 20103-20110 IN denotes whether
T15807 20111-20114 DT denotes the
T15808 20115-20121 NN denotes kinase
T15809 20122-20130 NN denotes activity
T15810 20131-20133 VBZ denotes is
T15811 20134-20142 VBN denotes required
T15812 20143-20146 IN denotes for
T15813 20147-20152 NNP denotes NleH1
T15814 20153-20155 TO denotes to
T15815 20156-20163 VB denotes inhibit
T15816 20164-20168 NNP denotes IKKβ
T15817 20169-20184 NN denotes phosphorlyation
T15818 20185-20187 IN denotes of
T15819 20188-20192 NNP denotes RPS3
T15820 20193-20195 IN denotes on
T15821 20196-20200 NNP denotes S209
T15822 20200-20201 , denotes ,
T15823 20202-20204 PRP denotes we
T15824 20205-20216 RB denotes ectopically
T15825 20217-20227 VBG denotes expressing
T15826 20228-20234 CC denotes either
T15827 20235-20244 JJ denotes wild-type
T15828 20245-20247 CC denotes or
T15829 20248-20253 NNP denotes K159A
T15830 20254-20259 NNP denotes NleH1
T15831 20260-20262 IN denotes in
T15832 20263-20267 NNP denotes 293T
T15833 20268-20273 NNS denotes cells
T15834 20273-20274 . denotes .
T15835 20275-20284 JJ denotes Wild-type
T15836 20285-20290 NNP denotes NleH1
T15837 20291-20301 NN denotes expression
T15838 20302-20315 RB denotes significantly
T15839 20316-20323 VBD denotes reduced
T15840 20324-20335 JJ denotes TNF-induced
T15841 20336-20340 NNP denotes RPS3
T15842 20341-20345 NNP denotes S209
T15843 20346-20361 NN denotes phosphorylation
T15844 20361-20362 , denotes ,
T15845 20363-20370 IN denotes whereas
T15846 20371-20374 DT denotes the
T15847 20375-20380 NNP denotes K159A
T15848 20381-20387 JJ denotes mutant
T15849 20388-20394 VBD denotes failed
T15850 20395-20397 TO denotes to
T15851 20398-20400 VB denotes do
T15852 20401-20403 RB denotes so
T15853 20404-20405 -LRB- denotes (
T15854 20405-20409 NNP denotes Fig.
T15855 20410-20412 CD denotes 7b
T15856 20412-20413 -RRB- denotes )
T15857 20413-20414 . denotes .
T15858 20415-20419 RB denotes Thus
T15859 20420-20425 JJ denotes NleH1
T15860 20426-20432 NN denotes kinase
T15861 20433-20441 NN denotes activity
T15862 20442-20444 VBZ denotes is
T15863 20445-20453 VBN denotes required
T15864 20454-20456 TO denotes to
T15865 20457-20464 VB denotes protect
T15866 20465-20469 CD denotes RPS3
T15867 20470-20474 IN denotes from
T15868 20475-20488 JJ denotes IKKβ-mediated
T15869 20489-20504 NN denotes phosphorylation
T15870 20504-20505 . denotes .
T15871 20506-20517 NNP denotes Citrobacter
T15872 20518-20527 NN denotes rodentium
T15873 20528-20530 VBZ denotes is
T15874 20531-20532 DT denotes a
T15875 20533-20538 NN denotes mouse
T15876 20539-20547 NN denotes pathogen
T15877 20548-20552 WDT denotes that
T15878 20553-20559 VBZ denotes shares
T15879 20560-20570 JJ denotes pathogenic
T15880 20571-20581 NNS denotes strategies
T15881 20582-20586 IN denotes with
T15882 20587-20589 NNP denotes E.
T15883 20590-20594 NNS denotes coli
T15884 20595-20597 CD denotes 39
T15885 20597-20598 , denotes ,
T15886 20599-20603 RBS denotes most
T15887 20604-20611 RB denotes notably
T15888 20612-20615 IN denotes for
T15889 20616-20619 PRP$ denotes our
T15890 20620-20633 NN denotes investigation
T15891 20633-20634 , denotes ,
T15892 20635-20637 NNP denotes C.
T15893 20638-20647 NN denotes rodentium
T15894 20648-20652 NNP denotes NleH
T15895 20653-20662 VBD denotes inhibited
T15896 20663-20667 CD denotes RPS3
T15897 20668-20675 JJ denotes nuclear
T15898 20676-20689 NN denotes translocation
T15899 20690-20693 CC denotes and
T15900 20694-20708 JJ denotes RPS3-dependent
T15901 20709-20714 NN denotes NF-κB
T15902 20715-20725 NN denotes luciferase
T15903 20726-20734 NN denotes activity
T15904 20735-20737 TO denotes to
T15905 20738-20740 DT denotes an
T15906 20741-20747 NN denotes extent
T15907 20748-20758 NN denotes equivalent
T15908 20759-20761 TO denotes to
T15909 20762-20764 NNP denotes E.
T15910 20765-20769 NNS denotes coli
T15911 20770-20775 NNP denotes NleH1
T15912 20776-20777 -LRB- denotes (
T15913 20777-20780 NN denotes ref
T15914 20780-20781 . denotes .
T15915 20782-20783 CD denotes 9
T15916 20783-20784 -RRB- denotes )
T15917 20784-20785 . denotes .
T15918 20786-20788 PRP denotes We
T15919 20789-20796 VBD denotes assayed
T15920 20797-20801 NNP denotes RPS3
T15921 20802-20806 NNP denotes S209
T15922 20807-20822 NN denotes phosphorylation
T15923 20823-20825 IN denotes in
T15924 20826-20830 NNP denotes HeLa
T15925 20831-20836 NNS denotes cells
T15926 20837-20845 VBN denotes infected
T15927 20846-20850 IN denotes with
T15928 20851-20860 JJ denotes different
T15929 20861-20863 NNP denotes C.
T15930 20864-20873 NN denotes rodentium
T15931 20874-20881 NNS denotes strains
T15932 20881-20882 . denotes .
T15933 20883-20885 IN denotes In
T15934 20886-20896 JJ denotes uninfected
T15935 20897-20902 NNS denotes cells
T15936 20902-20903 , denotes ,
T15937 20904-20917 JJ denotes TNF-treatment
T15938 20918-20928 VBD denotes stimulated
T15939 20929-20930 DT denotes a
T15940 20931-20932 NN denotes
T15941 20932-20940 JJ denotes 3.5-fold
T15942 20941-20949 NN denotes increase
T15943 20950-20952 IN denotes in
T15944 20953-20957 NNP denotes RPS3
T15945 20958-20962 NNP denotes S209
T15946 20963-20978 NN denotes phosphorylation
T15947 20979-20980 -LRB- denotes (
T15948 20980-20984 NNP denotes Fig.
T15949 20985-20987 CD denotes 7c
T15950 20987-20988 -RRB- denotes )
T15951 20988-20989 . denotes .
T15952 20990-20994 JJ denotes Such
T15953 20995-21007 NN denotes augmentation
T15954 21008-21010 IN denotes of
T15955 21011-21015 CD denotes RPS3
T15956 21016-21031 NN denotes phosphorylation
T15957 21032-21035 VBD denotes was
T15958 21036-21043 VBN denotes reduced
T15959 21044-21046 IN denotes by
T15960 21047-21052 RB denotes about
T15961 21053-21055 CD denotes 60
T15962 21055-21056 NN denotes %
T15963 21057-21059 IN denotes by
T15964 21060-21069 JJ denotes wild-type
T15965 21070-21072 NNP denotes C.
T15966 21073-21082 NN denotes rodentium
T15967 21083-21092 NN denotes infection
T15968 21093-21094 -LRB- denotes (
T15969 21094-21098 NNP denotes Fig.
T15970 21099-21101 CD denotes 7c
T15971 21101-21102 -RRB- denotes )
T15972 21102-21103 . denotes .
T15973 21104-21111 RB denotes However
T15974 21111-21112 , denotes ,
T15975 21113-21117 JJ denotes RPS3
T15976 21118-21133 NN denotes phosphorylation
T15977 21134-21137 VBD denotes was
T15978 21138-21146 VBN denotes enhanced
T15979 21147-21151 WRB denotes when
T15980 21152-21157 NNS denotes cells
T15981 21158-21162 VBD denotes were
T15982 21163-21171 VBN denotes infected
T15983 21172-21176 IN denotes with
T15984 21177-21178 DT denotes a
T15985 21179-21181 NNP denotes C.
T15986 21182-21191 NN denotes rodentium
T15987 21192-21198 NN denotes strain
T15988 21199-21206 VBG denotes lacking
T15989 21207-21211 NNP denotes NleH
T15990 21212-21213 -LRB- denotes (
T15991 21213-21217 NNP denotes Fig.
T15992 21218-21220 CD denotes 7c
T15993 21220-21221 , denotes ,
T15994 21222-21227 NNP denotes ΔnleH
T15995 21227-21228 -RRB- denotes )
T15996 21228-21229 . denotes .
T15997 21230-21232 PRP denotes We
T15998 21233-21240 RB denotes further
T15999 21241-21249 VBD denotes examined
T16000 21250-21253 DT denotes the
T16001 21254-21258 NN denotes role
T16002 21259-21261 IN denotes of
T16003 21262-21267 JJ denotes NleH1
T16004 21268-21274 NN denotes kinase
T16005 21275-21283 NN denotes activity
T16006 21284-21289 VBG denotes using
T16007 21290-21293 DT denotes the
T16008 21294-21296 NNP denotes C.
T16009 21297-21306 NN denotes rodentium
T16010 21307-21312 NNP denotes ΔnleH
T16011 21313-21319 NN denotes strain
T16012 21320-21322 IN denotes as
T16013 21323-21324 DT denotes a
T16014 21325-21335 NN denotes background
T16015 21336-21338 IN denotes on
T16016 21339-21344 WDT denotes which
T16017 21345-21347 TO denotes to
T16018 21348-21355 VB denotes express
T16019 21356-21362 DT denotes either
T16020 21363-21372 JJ denotes wild-type
T16021 21373-21375 CC denotes or
T16022 21376-21381 NNP denotes K159A
T16023 21382-21384 NNP denotes E.
T16024 21385-21389 NNS denotes coli
T16025 21390-21395 NNP denotes NleH1
T16026 21395-21396 . denotes .
T16027 21397-21410 VBG denotes Complementing
T16028 21411-21416 NNP denotes ΔnleH
T16029 21417-21423 JJ denotes mutant
T16030 21424-21428 IN denotes with
T16031 21429-21438 JJ denotes wild-type
T16032 21439-21444 NNP denotes NleH1
T16033 21445-21451 RB denotes almost
T16034 21452-21461 VBD denotes abolished
T16035 21462-21473 JJ denotes TNF-induced
T16036 21474-21478 NNP denotes RPS3
T16037 21479-21483 NNP denotes S209
T16038 21484-21499 NN denotes phosphorylation
T16039 21500-21507 IN denotes whereas
T16040 21508-21521 VBG denotes complementing
T16041 21522-21526 IN denotes with
T16042 21527-21532 NNP denotes K159A
T16043 21533-21539 VBD denotes failed
T16044 21540-21542 TO denotes to
T16045 21543-21550 VB denotes inhibit
T16046 21551-21555 JJ denotes RPS3
T16047 21556-21571 NN denotes phosphorylation
T16048 21572-21573 -LRB- denotes (
T16049 21573-21577 NNP denotes Fig.
T16050 21578-21580 CD denotes 7c
T16051 21580-21581 -RRB- denotes )
T16052 21581-21582 . denotes .
T16053 21583-21595 RB denotes Collectively
T16054 21595-21596 , denotes ,
T16055 21597-21602 DT denotes these
T16056 21603-21610 NNS denotes results
T16057 21611-21622 VBP denotes demonstrate
T16058 21623-21627 IN denotes that
T16059 21628-21633 JJ denotes NleH1
T16060 21634-21640 NN denotes kinase
T16061 21641-21649 NN denotes activity
T16062 21650-21652 VBZ denotes is
T16063 21653-21661 VBN denotes required
T16064 21662-21664 TO denotes to
T16065 21665-21670 VB denotes block
T16066 21671-21675 NNP denotes RPS3
T16067 21676-21680 NNP denotes S209
T16068 21681-21696 NN denotes phosphorylation
T16069 21696-21697 . denotes .
T16070 21698-21700 PRP denotes We
T16071 21701-21705 JJ denotes next
T16072 21706-21714 VBD denotes examined
T16073 21715-21722 IN denotes whether
T16074 21723-21726 DT denotes the
T16075 21727-21737 JJ denotes inhibitory
T16076 21738-21746 NN denotes activity
T16077 21747-21749 IN denotes of
T16078 21750-21755 NNP denotes NleH1
T16079 21756-21758 VBZ denotes is
T16080 21759-21771 RB denotes sufficiently
T16081 21772-21778 JJ denotes robust
T16082 21779-21781 TO denotes to
T16083 21782-21788 VB denotes impair
T16084 21789-21792 DT denotes the
T16085 21793-21799 JJ denotes strong
T16086 21800-21807 JJ denotes nuclear
T16087 21808-21821 NN denotes translocation
T16088 21822-21824 IN denotes of
T16089 21825-21829 CD denotes RPS3
T16090 21830-21837 VBN denotes trigged
T16091 21838-21840 IN denotes by
T16092 21841-21844 DT denotes the
T16093 21845-21866 JJ denotes constitutively-active
T16094 21867-21871 NNP denotes IKKβ
T16095 21872-21873 -LRB- denotes (
T16096 21873-21877 NNP denotes IKKβ
T16097 21878-21879 NNP denotes [
T16098 21879-21883 NNP denotes SSEE
T16099 21883-21884 NNP denotes ]
T16100 21884-21885 -RRB- denotes )
T16101 21886-21887 -LRB- denotes (
T16102 21887-21891 NNP denotes Fig.
T16103 21892-21894 CD denotes 2d
T16104 21894-21895 -RRB- denotes )
T16105 21895-21896 . denotes .
T16106 21897-21899 PRP denotes We
T16107 21900-21905 VBD denotes found
T16108 21906-21910 IN denotes that
T16109 21911-21922 RB denotes ectopically
T16110 21923-21933 VBG denotes expressing
T16111 21934-21940 CC denotes either
T16112 21941-21950 JJ denotes wild-type
T16113 21951-21953 CC denotes or
T16114 21954-21958 NNP denotes SSEE
T16115 21959-21963 NNP denotes IKKβ
T16116 21964-21972 NNS denotes proteins
T16117 21972-21973 , denotes ,
T16118 21974-21983 VBD denotes triggered
T16119 21984-21988 RBR denotes more
T16120 21989-21993 JJ denotes RPS3
T16121 21994-22001 JJ denotes nuclear
T16122 22002-22015 NN denotes translocation
T16123 22016-22020 IN denotes than
T16124 22021-22024 DT denotes the
T16125 22025-22036 JJ denotes kinase-dead
T16126 22037-22041 NNP denotes IKKβ
T16127 22042-22043 -LRB- denotes (
T16128 22043-22047 NNP denotes SSAA
T16129 22047-22048 -RRB- denotes )
T16130 22049-22056 NN denotes protein
T16131 22057-22058 -LRB- denotes (
T16132 22058-22062 NNP denotes Fig.
T16133 22063-22065 CD denotes 7d
T16134 22065-22066 -RRB- denotes )
T16135 22066-22067 . denotes .
T16136 22068-22072 CD denotes RPS3
T16137 22073-22080 JJ denotes nuclear
T16138 22081-22093 NN denotes accumulation
T16139 22094-22097 VBD denotes was
T16140 22098-22111 RB denotes substantially
T16141 22112-22120 JJ denotes retarded
T16142 22121-22123 IN denotes by
T16143 22124-22133 VBG denotes infecting
T16144 22134-22139 NNS denotes cells
T16145 22140-22144 IN denotes with
T16146 22145-22154 JJ denotes wild-type
T16147 22155-22157 NNP denotes E.
T16148 22158-22162 NNS denotes coli
T16149 22163-22167 NNP denotes O157
T16150 22167-22168 : denotes :
T16151 22168-22170 NNP denotes H7
T16152 22171-22172 -LRB- denotes (
T16153 22172-22176 NNP denotes Fig.
T16154 22177-22179 CD denotes 7d
T16155 22179-22180 -RRB- denotes )
T16156 22180-22181 . denotes .
T16157 22182-22184 IN denotes In
T16158 22185-22193 NN denotes contrast
T16159 22193-22194 , denotes ,
T16160 22195-22204 VBG denotes infecting
T16161 22205-22209 IN denotes with
T16162 22210-22216 DT denotes either
T16163 22217-22223 NNP denotes ΔnleH1
T16164 22224-22226 CC denotes or
T16165 22227-22232 NNP denotes ΔescN
T16166 22233-22240 NNS denotes strains
T16167 22241-22245 RB denotes only
T16168 22246-22254 RB denotes slightly
T16169 22255-22263 VBN denotes impaired
T16170 22264-22268 NNP denotes RPS3
T16171 22269-22276 JJ denotes nuclear
T16172 22277-22290 NN denotes translocation
T16173 22291-22293 IN denotes in
T16174 22294-22300 CC denotes either
T16175 22301-22305 SYM denotes IKKβ
T16176 22305-22306 : denotes -
T16177 22307-22309 CC denotes or
T16178 22310-22314 NNP denotes IKKβ
T16179 22315-22316 -LRB- denotes (
T16180 22316-22320 NNP denotes SSEE
T16181 22320-22321 -RRB- denotes )
T16182 22321-22322 : denotes -
T16183 22322-22332 VBG denotes expressing
T16184 22333-22338 NNS denotes cells
T16185 22339-22340 -LRB- denotes (
T16186 22340-22344 NNP denotes Fig.
T16187 22345-22347 CD denotes 7d
T16188 22347-22348 -RRB- denotes )
T16189 22348-22349 . denotes .
T16190 22350-22352 IN denotes As
T16191 22353-22361 VBN denotes expected
T16192 22361-22362 , denotes ,
T16193 22363-22365 NNP denotes E.
T16194 22366-22370 NNS denotes coli
T16195 22371-22381 NNS denotes infections
T16196 22382-22385 VBD denotes did
T16197 22386-22389 RB denotes not
T16198 22390-22396 VB denotes affect
T16199 22397-22400 DT denotes the
T16200 22401-22405 JJ denotes RPS3
T16201 22406-22413 JJ denotes nuclear
T16202 22414-22427 NN denotes translocation
T16203 22428-22430 IN denotes in
T16204 22431-22435 NNP denotes IKKβ
T16205 22436-22437 -LRB- denotes (
T16206 22437-22441 NNP denotes SSAA
T16207 22441-22442 -RRB- denotes )
T16208 22442-22443 : denotes -
T16209 22443-22453 VBG denotes expressing
T16210 22454-22459 NNS denotes cells
T16211 22459-22460 , denotes ,
T16212 22461-22466 WRB denotes where
T16213 22467-22472 JJ denotes NF-κB
T16214 22473-22482 VBG denotes signaling
T16215 22483-22486 VBD denotes was
T16216 22487-22490 JJ denotes low
T16217 22491-22492 -LRB- denotes (
T16218 22492-22496 NNP denotes Fig.
T16219 22497-22499 CD denotes 7d
T16220 22499-22500 -RRB- denotes )
T16221 22500-22501 . denotes .
T16222 22502-22506 RB denotes Thus
T16223 22506-22507 , denotes ,
T16224 22508-22514 IN denotes during
T16225 22515-22524 NN denotes infection
T16226 22525-22530 NNP denotes NleH1
T16227 22531-22533 VBZ denotes is
T16228 22534-22546 RB denotes sufficiently
T16229 22547-22553 JJ denotes potent
T16230 22554-22556 TO denotes to
T16231 22557-22564 VB denotes inhibit
T16232 22565-22569 JJ denotes RPS3
T16233 22570-22577 JJ denotes nuclear
T16234 22578-22591 NN denotes translocation
T16235 22592-22596 RB denotes even
T16236 22597-22599 IN denotes in
T16237 22600-22605 NNS denotes cells
T16238 22606-22616 VBG denotes expressing
T16239 22617-22641 JJ denotes constitutively-activated
T16240 22642-22646 NNP denotes IKKβ
T16241 22646-22647 . denotes .
T16242 22648-22650 PRP denotes We
T16243 22651-22659 VBD denotes examined
T16244 22660-22667 IN denotes whether
T16245 22668-22673 NNP denotes NleH1
T16246 22674-22679 MD denotes could
T16247 22680-22688 RB denotes directly
T16248 22689-22702 VB denotes phosphorylate
T16249 22703-22707 NNP denotes IKKβ
T16250 22708-22712 RB denotes thus
T16251 22713-22723 VBG denotes inhibiting
T16252 22724-22737 JJ denotes IKKβ-mediated
T16253 22738-22742 CD denotes RPS3
T16254 22743-22747 CD denotes S209
T16255 22748-22763 NN denotes phosphorylation
T16256 22763-22764 . denotes .
T16257 22765-22767 PRP denotes We
T16258 22768-22777 VBD denotes performed
T16259 22778-22780 IN denotes in
T16260 22781-22786 NN denotes vitro
T16261 22787-22793 NN denotes kinase
T16262 22794-22800 VBZ denotes assays
T16263 22801-22806 VBG denotes using
T16264 22807-22825 VBN denotes immunoprecipitated
T16265 22826-22835 NNP denotes Flag-IKKβ
T16266 22836-22837 -LRB- denotes (
T16267 22837-22841 NNP denotes K44A
T16268 22841-22842 -RRB- denotes )
T16269 22843-22845 IN denotes as
T16270 22846-22855 NN denotes substrate
T16271 22856-22859 CC denotes and
T16272 22860-22871 JJ denotes recombinant
T16273 22872-22881 NN denotes His-NleH1
T16274 22882-22884 IN denotes as
T16275 22885-22891 NN denotes kinase
T16276 22891-22892 , denotes ,
T16277 22893-22895 RB denotes so
T16278 22896-22900 IN denotes that
T16279 22901-22905 NNP denotes IKKβ
T16280 22906-22925 NN denotes autophosphorylation
T16281 22926-22931 MD denotes would
T16282 22932-22935 RB denotes not
T16283 22936-22943 VB denotes obscure
T16284 22944-22957 JJ denotes NleH1-induced
T16285 22958-22973 NN denotes phosphorylation
T16286 22973-22974 . denotes .
T16287 22975-22982 RB denotes However
T16288 22982-22983 , denotes ,
T16289 22984-22986 PRP denotes we
T16290 22987-22990 VBD denotes did
T16291 22991-22994 RB denotes not
T16292 22995-23002 VB denotes observe
T16293 23003-23006 DT denotes any
T16294 23007-23017 JJ denotes detectable
T16295 23018-23021 NNP denotes 32P
T16296 23022-23035 NN denotes incorporation
T16297 23036-23038 IN denotes in
T16298 23039-23043 NNP denotes IKKβ
T16299 23044-23045 -LRB- denotes (
T16300 23045-23058 NNP denotes Supplementary
T16301 23059-23063 NNP denotes Fig.
T16302 23064-23066 CD denotes 13
T16303 23066-23067 -RRB- denotes )
T16304 23067-23068 , denotes ,
T16305 23069-23073 RB denotes thus
T16306 23074-23080 VBG denotes ruling
T16307 23081-23084 RP denotes out
T16308 23085-23089 DT denotes this
T16309 23090-23101 NN denotes possibility
T16310 23101-23102 . denotes .
T16311 23103-23105 PRP denotes We
T16312 23106-23110 RB denotes then
T16313 23111-23117 VBD denotes tested
T16314 23118-23121 DT denotes the
T16315 23122-23132 NN denotes hypothesis
T16316 23133-23137 WDT denotes that
T16317 23138-23143 NNP denotes NleH1
T16318 23144-23149 MD denotes could
T16319 23150-23155 VB denotes alter
T16320 23156-23159 DT denotes the
T16321 23160-23164 NNP denotes IKKβ
T16322 23165-23174 NN denotes substrate
T16323 23175-23188 NNS denotes specificities
T16324 23188-23189 . denotes .
T16325 23190-23192 TO denotes To
T16326 23193-23197 DT denotes this
T16327 23198-23201 NN denotes end
T16328 23201-23202 , denotes ,
T16329 23203-23205 PRP denotes we
T16330 23206-23215 VBD denotes performed
T16331 23216-23218 IN denotes in
T16332 23219-23224 NN denotes vitro
T16333 23225-23231 NN denotes kinase
T16334 23232-23238 VBZ denotes assays
T16335 23239-23244 VBG denotes using
T16336 23245-23249 DT denotes both
T16337 23250-23253 CD denotes CK2
T16338 23254-23257 CC denotes and
T16339 23258-23261 NNP denotes IKK
T16340 23262-23272 VBZ denotes substrates
T16341 23273-23276 IN denotes for
T16342 23277-23281 NNP denotes IKKβ
T16343 23281-23282 . denotes .
T16344 23283-23285 IN denotes As
T16345 23286-23294 VBN denotes expected
T16346 23294-23295 , denotes ,
T16347 23296-23300 NNP denotes IKKβ
T16348 23301-23315 VBD denotes phosphorylated
T16349 23316-23320 NNP denotes RPS3
T16350 23321-23322 -LRB- denotes (
T16351 23322-23326 NNP denotes Fig.
T16352 23327-23329 CD denotes 7e
T16353 23329-23330 , denotes ,
T16354 23331-23335 NN denotes lane
T16355 23336-23337 CD denotes 7
T16356 23337-23338 -RRB- denotes )
T16357 23339-23342 CC denotes and
T16358 23343-23351 NNP denotes GST-IκBα
T16359 23352-23353 -LRB- denotes (
T16360 23353-23357 CD denotes 1-54
T16361 23357-23358 -RRB- denotes )
T16362 23359-23366 NN denotes protein
T16363 23367-23368 -LRB- denotes (
T16364 23368-23372 NNP denotes Fig.
T16365 23373-23375 CD denotes 7e
T16366 23375-23376 , denotes ,
T16367 23377-23381 NN denotes lane
T16368 23382-23383 CD denotes 9
T16369 23383-23384 -RRB- denotes )
T16370 23384-23385 , denotes ,
T16371 23386-23399 VBG denotes demonstrating
T16372 23400-23402 PRP denotes it
T16373 23403-23410 VBZ denotes harbors
T16374 23411-23417 CC denotes either
T16375 23418-23421 CD denotes CK2
T16376 23422-23424 CC denotes or
T16377 23425-23428 NNP denotes IKK
T16378 23429-23438 VBP denotes substrate
T16379 23439-23450 NN denotes specificity
T16380 23450-23451 . denotes .
T16381 23452-23465 NNP denotes Preincubation
T16382 23466-23468 IN denotes of
T16383 23469-23473 NNP denotes IKKβ
T16384 23474-23478 IN denotes with
T16385 23479-23484 NNP denotes NleH1
T16386 23485-23492 VBD denotes reduced
T16387 23493-23506 JJ denotes IKKβ-mediated
T16388 23507-23511 JJ denotes RPS3
T16389 23512-23527 NN denotes phosphorylation
T16390 23527-23528 , denotes ,
T16391 23529-23533 FW denotes i.e.
T16392 23534-23537 DT denotes the
T16393 23538-23541 NNP denotes CK2
T16394 23542-23548 NN denotes kinase
T16395 23549-23560 NN denotes specificity
T16396 23560-23561 , denotes ,
T16397 23562-23565 CC denotes but
T16398 23566-23569 RB denotes not
T16399 23570-23583 JJ denotes IKKβ-mediated
T16400 23584-23592 JJ denotes GST-IκBα
T16401 23593-23608 NN denotes phosphorylation
T16402 23608-23609 , denotes ,
T16403 23610-23614 FW denotes i.e.
T16404 23615-23618 DT denotes the
T16405 23619-23622 NNP denotes IKK
T16406 23623-23629 NN denotes kinase
T16407 23630-23641 NN denotes specificity
T16408 23642-23643 -LRB- denotes (
T16409 23643-23647 NNP denotes Fig.
T16410 23648-23650 CD denotes 7e
T16411 23650-23651 -RRB- denotes )
T16412 23651-23652 . denotes .
T16413 23653-23660 NNP denotes Control
T16414 23661-23672 NNS denotes experiments
T16415 23673-23681 VBD denotes revealed
T16416 23682-23684 DT denotes no
T16417 23685-23699 JJ denotes NleH1-mediated
T16418 23700-23715 NN denotes phosphorylation
T16419 23716-23718 CC denotes or
T16420 23719-23738 NN denotes autophosphorylation
T16421 23739-23741 IN denotes of
T16422 23742-23746 CD denotes RPS3
T16423 23747-23749 CC denotes or
T16424 23750-23758 NNP denotes GST-IκBα
T16425 23759-23760 -LRB- denotes (
T16426 23760-23764 NNP denotes Fig.
T16427 23765-23767 CD denotes 7e
T16428 23767-23768 -RRB- denotes )
T16429 23768-23769 . denotes .
T16430 23770-23775 VBN denotes Taken
T16431 23776-23784 RB denotes together
T16432 23784-23785 , denotes ,
T16433 23786-23791 JJ denotes NleH1
T16434 23792-23798 NNS denotes blocks
T16435 23799-23802 DT denotes the
T16436 23803-23806 NNP denotes CK2
T16437 23807-23816 NN denotes substrate
T16438 23817-23828 NN denotes specificity
T16439 23829-23831 IN denotes of
T16440 23832-23836 NNP denotes IKKβ
T16441 23837-23841 RB denotes thus
T16442 23842-23852 VBG denotes inhibiting
T16443 23853-23856 DT denotes the
T16444 23857-23870 JJ denotes IKKβ-mediated
T16445 23871-23875 CD denotes RPS3
T16446 23876-23880 CD denotes S209
T16447 23881-23896 NN denotes phosphorylation
T16448 23897-23901 RB denotes thus
T16449 23902-23914 VBG denotes representing
T16450 23915-23916 DT denotes a
T16451 23917-23922 NN denotes novel
T16452 23923-23931 NN denotes strategy
T16453 23932-23934 IN denotes by
T16454 23935-23937 NNP denotes E.
T16455 23938-23942 NNS denotes coli
T16456 23943-23947 NNP denotes O157
T16457 23947-23948 : denotes :
T16458 23948-23950 NNP denotes H7
T16459 23951-23953 TO denotes to
T16460 23954-23959 VB denotes alter
T16461 23960-23963 DT denotes the
T16462 23964-23968 NN denotes host
T16463 23969-23975 NN denotes innate
T16464 23976-23982 JJ denotes immune
T16465 23983-23991 NN denotes response
T16466 23991-23992 . denotes .
T18827 24005-24009 CD denotes RPS3
T18828 24010-24013 VBD denotes was
T18829 24014-24024 RB denotes previously
T18830 24025-24037 VBN denotes demonstrated
T18831 24038-24040 TO denotes to
T18832 24041-24049 VB denotes function
T18833 24050-24052 IN denotes as
T18834 24053-24055 DT denotes an
T18835 24056-24064 JJ denotes integral
T18836 24065-24072 NN denotes subunit
T18837 24073-24083 VBG denotes conferring
T18838 24084-24089 JJ denotes NF-κB
T18839 24090-24100 JJ denotes regulatory
T18840 24101-24113 NN denotes specificity6
T18841 24113-24114 . denotes .
T18842 24115-24119 RB denotes Here
T18843 24120-24122 PRP denotes we
T18844 24123-24129 VBD denotes sought
T18845 24130-24132 TO denotes to
T18846 24133-24142 VB denotes elucidate
T18847 24143-24146 WRB denotes how
T18848 24147-24152 JJ denotes NF-κB
T18849 24153-24163 NN denotes activation
T18850 24164-24173 VBG denotes signaling
T18851 24174-24182 VBZ denotes triggers
T18852 24183-24187 CD denotes RPS3
T18853 24188-24190 TO denotes to
T18854 24191-24202 VB denotes translocate
T18855 24203-24206 CC denotes and
T18856 24207-24218 VB denotes participate
T18857 24219-24221 IN denotes in
T18858 24222-24227 JJ denotes NF-κB
T18859 24228-24236 NN denotes function
T18860 24237-24239 IN denotes in
T18861 24240-24243 DT denotes the
T18862 24244-24251 NN denotes nucleus
T18863 24251-24252 . denotes .
T18864 24253-24255 PRP denotes We
T18865 24256-24267 VBP denotes demonstrate
T18866 24268-24272 IN denotes that
T18867 24273-24286 JJ denotes IKKβ-mediated
T18868 24287-24291 CD denotes RPS3
T18869 24292-24296 CD denotes S209
T18870 24297-24312 NN denotes phosphorylation
T18871 24313-24323 VBZ denotes represents
T18872 24324-24325 DT denotes a
T18873 24326-24334 JJ denotes critical
T18874 24335-24346 NN denotes determinant
T18875 24347-24349 IN denotes in
T18876 24350-24359 VBG denotes governing
T18877 24360-24363 PRP$ denotes its
T18878 24364-24371 JJ denotes nuclear
T18879 24372-24378 NN denotes import
T18880 24379-24383 RB denotes thus
T18881 24384-24393 VBG denotes unveiling
T18882 24394-24395 DT denotes a
T18883 24396-24401 NN denotes novel
T18884 24402-24411 NN denotes mechanism
T18885 24412-24418 IN denotes behind
T18886 24419-24424 JJ denotes NF-κB
T18887 24425-24435 JJ denotes regulatory
T18888 24436-24447 NN denotes specificity
T18889 24447-24448 . denotes .
T18890 24449-24453 NNP denotes IKKβ
T18891 24454-24456 VBZ denotes is
T18892 24457-24460 DT denotes the
T18893 24461-24466 JJ denotes major
T18894 24467-24473 NN denotes kinase
T18895 24474-24478 WDT denotes that
T18896 24479-24493 VBZ denotes phosphorylates
T18897 24494-24498 NNS denotes IκBs
T18898 24499-24501 IN denotes in
T18899 24502-24505 DT denotes the
T18900 24506-24515 JJ denotes classical
T18901 24516-24521 NN denotes NF-κB
T18902 24522-24529 NN denotes pathway
T18903 24529-24530 , denotes ,
T18904 24531-24538 VBG denotes leading
T18905 24539-24541 TO denotes to
T18906 24542-24547 PRP$ denotes their
T18907 24548-24558 JJ denotes subsequent
T18908 24559-24572 NN denotes degradation40
T18909 24572-24573 . denotes .
T18910 24574-24584 RB denotes Strikingly
T18911 24584-24585 , denotes ,
T18912 24586-24590 JJ denotes RPS3
T18913 24591-24600 VBZ denotes possesses
T18914 24601-24604 RB denotes not
T18915 24605-24608 DT denotes any
T18916 24609-24618 NN denotes consensus
T18917 24619-24622 NNP denotes IKK
T18918 24623-24628 NN denotes motif
T18919 24628-24629 : denotes ;
T18920 24630-24637 RB denotes instead
T18921 24637-24638 , denotes ,
T18922 24639-24643 NNP denotes S209
T18923 24644-24646 VBZ denotes is
T18924 24647-24655 VBN denotes centered
T18925 24656-24658 IN denotes in
T18926 24659-24660 DT denotes a
T18927 24661-24670 NN denotes consensus
T18928 24671-24674 NNP denotes CK2
T18929 24675-24680 NN denotes motif
T18930 24680-24681 . denotes .
T18931 24682-24685 DT denotes The
T18932 24686-24692 JJ denotes recent
T18933 24693-24704 NN denotes observation
T18934 24705-24709 WDT denotes that
T18935 24710-24715 JJ denotes human
T18936 24716-24720 NNP denotes IKKβ
T18937 24721-24730 VBD denotes displayed
T18938 24731-24739 JJ denotes CK2-like
T18939 24740-24755 NN denotes phosphorylation
T18940 24756-24769 CD denotes specificity29
T18941 24770-24779 NNS denotes coincides
T18942 24780-24784 IN denotes with
T18943 24785-24788 PRP$ denotes our
T18944 24789-24797 NN denotes evidence
T18945 24798-24802 IN denotes that
T18946 24803-24814 JJ denotes recombinant
T18947 24815-24819 NNP denotes IKKβ
T18948 24819-24820 , denotes ,
T18949 24821-24824 CC denotes but
T18950 24825-24828 RB denotes not
T18951 24829-24833 NNP denotes IKKα
T18952 24833-24834 , denotes ,
T18953 24835-24849 VBD denotes phosphorylated
T18954 24850-24854 NNP denotes RPS3
T18955 24854-24855 . denotes .
T18956 24856-24858 PRP denotes We
T18957 24859-24864 VBD denotes found
T18958 24865-24869 DT denotes this
T18959 24870-24885 NN denotes phosphorylation
T18960 24886-24888 VBZ denotes is
T18961 24889-24890 DT denotes a
T18962 24891-24899 JJ denotes critical
T18963 24900-24910 NN denotes modulation
T18964 24911-24914 IN denotes for
T18965 24915-24919 NNP denotes RPS3
T18966 24920-24927 JJ denotes nuclear
T18967 24928-24941 NN denotes translocation
T18968 24942-24943 -LRB- denotes (
T18969 24943-24946 IN denotes via
T18970 24947-24957 JJ denotes importin-α
T18971 24957-24958 -RRB- denotes )
T18972 24959-24962 CC denotes and
T18973 24963-24973 NN denotes engagement
T18974 24974-24976 IN denotes in
T18975 24977-24985 JJ denotes specific
T18976 24986-24991 NN denotes NF-κB
T18977 24992-25005 NN denotes transcription
T18978 25005-25006 . denotes .
T18979 25007-25010 CD denotes CK2
T18980 25011-25014 VBD denotes was
T18981 25015-25025 RB denotes previously
T18982 25026-25031 VBN denotes shown
T18983 25032-25034 TO denotes to
T18984 25035-25048 VB denotes phosphorylate
T18985 25049-25052 NNS denotes p65
T18986 25053-25056 CC denotes and
T18987 25057-25059 TO denotes to
T18988 25060-25064 NN denotes bind
T18989 25065-25067 TO denotes to
T18990 25068-25071 CC denotes and
T18991 25072-25085 VB denotes phosphorylate
T18992 25086-25095 JJ denotes IKKβ41-43
T18993 25095-25096 , denotes ,
T18994 25097-25104 RB denotes however
T18995 25104-25105 , denotes ,
T18996 25106-25108 PRP denotes we
T18997 25109-25114 VBD denotes ruled
T18998 25115-25118 RP denotes out
T18999 25119-25122 DT denotes the
T19000 25123-25134 NN denotes possibility
T19001 25135-25139 IN denotes that
T19002 25140-25143 DT denotes the
T19003 25144-25154 JJ denotes IKKβ-bound
T19004 25155-25158 NN denotes CK2
T19005 25159-25164 MD denotes could
T19006 25165-25172 VB denotes account
T19007 25173-25176 IN denotes for
T19008 25177-25180 DT denotes the
T19009 25181-25189 JJ denotes observed
T19010 25190-25194 NN denotes RPS3
T19011 25195-25210 NN denotes phosphorylation
T19012 25211-25218 IN denotes because
T19013 25219-25221 DT denotes no
T19014 25222-25225 NN denotes CK2
T19015 25226-25229 VBD denotes was
T19016 25230-25238 VBN denotes detected
T19017 25239-25241 IN denotes in
T19018 25242-25245 DT denotes the
T19019 25246-25250 NNP denotes IKKβ
T19020 25251-25263 NNS denotes preparations
T19021 25264-25268 VBD denotes used
T19022 25269-25272 IN denotes for
T19023 25273-25276 DT denotes the
T19024 25277-25279 IN denotes in
T19025 25280-25285 NN denotes vitro
T19026 25286-25292 NN denotes kinase
T19027 25293-25298 NN denotes assay
T19028 25298-25299 . denotes .
T19029 25300-25307 IN denotes Because
T19030 25308-25312 CD denotes RPS3
T19031 25313-25317 RB denotes only
T19032 25318-25325 VBZ denotes harbors
T19033 25326-25329 DT denotes the
T19034 25330-25333 NNP denotes CK2
T19035 25334-25339 NN denotes motif
T19036 25340-25343 CC denotes and
T19037 25344-25347 RB denotes not
T19038 25348-25349 DT denotes a
T19039 25350-25361 JJ denotes traditional
T19040 25362-25365 NNP denotes IKK
T19041 25366-25371 NN denotes motif
T19042 25371-25372 , denotes ,
T19043 25373-25377 DT denotes this
T19044 25378-25382 JJ denotes RPS3
T19045 25383-25393 JJ denotes regulatory
T19046 25394-25402 NN denotes function
T19047 25403-25408 MD denotes could
T19048 25409-25416 VB denotes explain
T19049 25417-25420 WRB denotes why
T19050 25421-25424 NNP denotes IKK
T19051 25425-25432 VBZ denotes harbors
T19052 25433-25436 DT denotes the
T19053 25437-25448 JJ denotes alternative
T19054 25449-25458 JJ denotes substrate
T19055 25459-25474 NN denotes phosphorylation
T19056 25475-25485 NN denotes capability
T19057 25485-25486 . denotes .
T19058 25487-25491 RBR denotes More
T19059 25492-25503 RB denotes importantly
T19060 25503-25504 , denotes ,
T19061 25505-25508 PRP$ denotes our
T19062 25509-25514 NN denotes study
T19063 25515-25518 VBZ denotes has
T19064 25519-25529 VBN denotes elucidated
T19065 25530-25533 WRB denotes how
T19066 25534-25538 NNP denotes RPS3
T19067 25539-25541 VBZ denotes is
T19068 25542-25555 RB denotes biochemically
T19069 25556-25566 VBN denotes integrated
T19070 25567-25571 IN denotes into
T19071 25572-25577 JJ denotes NF-κB
T19072 25578-25588 NN denotes activation
T19073 25589-25598 VBG denotes signaling
T19074 25599-25601 IN denotes in
T19075 25602-25603 DT denotes a
T19076 25604-25610 NN denotes manner
T19077 25611-25615 WDT denotes that
T19078 25616-25618 VBZ denotes is
T19079 25619-25626 JJ denotes pivotal
T19080 25627-25630 IN denotes for
T19081 25631-25634 DT denotes the
T19082 25635-25647 NN denotes pathogenesis
T19083 25648-25650 IN denotes of
T19084 25651-25660 NN denotes foodborne
T19085 25661-25669 NN denotes pathogen
T19086 25670-25672 NNP denotes E.
T19087 25673-25677 NNS denotes coli
T19088 25678-25682 NNP denotes O157
T19089 25682-25683 : denotes :
T19090 25683-25685 NNP denotes H7
T19091 25685-25686 . denotes .
T19092 25687-25700 JJ denotes IKKβ-mediated
T19093 25701-25705 NNP denotes RPS3
T19094 25706-25710 NNP denotes S209
T19095 25711-25726 NN denotes phosphorylation
T19096 25727-25729 VBZ denotes is
T19097 25730-25731 DT denotes a
T19098 25732-25740 JJ denotes critical
T19099 25741-25747 NN denotes target
T19100 25748-25757 VBN denotes modulated
T19101 25758-25760 IN denotes by
T19102 25761-25765 DT denotes this
T19103 25766-25774 NN denotes pathogen
T19104 25775-25777 TO denotes to
T19105 25778-25785 VB denotes subvert
T19106 25786-25790 NN denotes host
T19107 25791-25796 NN denotes NF-κB
T19108 25797-25806 VBG denotes signaling
T19109 25806-25807 . denotes .
T19110 25808-25811 DT denotes The
T19111 25812-25821 JJ denotes bacterial
T19112 25822-25830 NN denotes effector
T19113 25831-25836 NNP denotes NleH1
T19114 25837-25849 RB denotes specifically
T19115 25850-25855 VBZ denotes binds
T19116 25856-25858 TO denotes to
T19117 25859-25863 CD denotes RPS3
T19118 25864-25868 RB denotes once
T19119 25869-25877 VBD denotes injected
T19120 25878-25882 IN denotes into
T19121 25883-25887 NN denotes host
T19122 25888-25893 NNS denotes cells
T19123 25894-25897 CC denotes and
T19124 25898-25908 RB denotes profoundly
T19125 25909-25919 VBZ denotes suppresses
T19126 25920-25925 NNP denotes NF-κB
T19127 25926-25929 CC denotes and
T19128 25930-25933 PRP$ denotes its
T19129 25934-25943 JJ denotes attendant
T19130 25944-25954 JJ denotes protective
T19131 25955-25961 JJ denotes immune
T19132 25962-25972 NN denotes responses9
T19133 25972-25973 . denotes .
T19134 25974-25977 PRP$ denotes Our
T19135 25978-25982 NNS denotes data
T19136 25983-25986 RB denotes now
T19137 25987-25991 VBP denotes show
T19138 25992-25996 IN denotes that
T19139 25997-26002 JJ denotes NleH1
T19140 26003-26014 RB denotes selectively
T19141 26015-26023 VBZ denotes inhibits
T19142 26024-26028 CD denotes RPS3
T19143 26029-26044 NN denotes phosphorylation
T19144 26044-26045 , denotes ,
T19145 26046-26050 RB denotes thus
T19146 26051-26060 VBG denotes retarding
T19147 26061-26064 PRP$ denotes its
T19148 26065-26072 JJ denotes nuclear
T19149 26073-26086 NN denotes translocation
T19150 26087-26090 CC denotes and
T19151 26091-26101 JJ denotes subsequent
T19152 26102-26107 NN denotes NF-κB
T19153 26108-26116 NN denotes function
T19154 26116-26117 , denotes ,
T19155 26118-26125 IN denotes without
T19156 26126-26134 VBG denotes altering
T19157 26135-26140 JJ denotes other
T19158 26141-26146 JJ denotes NF-κB
T19159 26147-26156 VBG denotes signaling
T19160 26156-26157 . denotes .
T19161 26158-26166 IN denotes Although
T19162 26167-26172 NNP denotes NleH1
T19163 26173-26176 VBD denotes did
T19164 26177-26180 RB denotes not
T19165 26181-26189 RB denotes directly
T19166 26190-26203 VB denotes phosphorylate
T19167 26204-26208 NNP denotes IKKβ
T19168 26208-26209 , denotes ,
T19169 26210-26213 PRP$ denotes its
T19170 26214-26220 NN denotes kinase
T19171 26221-26229 NN denotes activity
T19172 26230-26233 VBD denotes was
T19173 26234-26242 VBN denotes required
T19174 26243-26245 TO denotes to
T19175 26246-26253 VB denotes inhibit
T19176 26254-26267 JJ denotes IKKβ-mediated
T19177 26268-26272 NNP denotes RPS3
T19178 26273-26277 NNP denotes S209
T19179 26278-26293 NN denotes phosphorylation
T19180 26293-26294 . denotes .
T19181 26295-26299 JJ denotes Many
T19182 26300-26308 NNS denotes bacteria
T19183 26309-26318 NNS denotes pathogens
T19184 26319-26323 VBP denotes have
T19185 26324-26332 NNS denotes products
T19186 26333-26337 WDT denotes that
T19187 26338-26344 VBP denotes target
T19188 26345-26348 JJ denotes key
T19189 26349-26356 NNS denotes kinases
T19190 26357-26359 TO denotes to
T19191 26360-26370 VB denotes inactivate
T19192 26371-26375 PRP denotes them
T19193 26376-26378 IN denotes in
T19194 26379-26383 NN denotes host
T19195 26384-26389 NNS denotes cells
T19196 26389-26390 , denotes ,
T19197 26391-26398 IN denotes whereas
T19198 26399-26401 NNP denotes E.
T19199 26402-26406 NNS denotes coli
T19200 26407-26411 NNP denotes O157
T19201 26411-26412 : denotes :
T19202 26412-26414 NNP denotes H7
T19203 26415-26423 VBN denotes employed
T19204 26424-26429 NNP denotes NleH1
T19205 26430-26432 TO denotes to
T19206 26433-26438 VB denotes steer
T19207 26439-26442 DT denotes the
T19208 26443-26452 JJ denotes substrate
T19209 26453-26464 NN denotes specificity
T19210 26465-26467 IN denotes of
T19211 26468-26472 NNP denotes IKKβ
T19212 26473-26477 RB denotes thus
T19213 26478-26490 RB denotes specifically
T19214 26491-26502 VB denotes fine-tuning
T19215 26503-26507 NN denotes host
T19216 26508-26513 NN denotes NF-κB
T19217 26514-26523 VBG denotes signaling
T19218 26523-26524 . denotes .
T19219 26525-26529 DT denotes This
T19220 26530-26535 MD denotes could
T19221 26536-26545 VB denotes represent
T19222 26546-26547 DT denotes a
T19223 26548-26553 NN denotes novel
T19224 26554-26562 NN denotes strategy
T19225 26563-26565 TO denotes to
T19226 26566-26575 VB denotes fine-tune
T19227 26576-26580 NN denotes host
T19228 26581-26586 NN denotes NF-κB
T19229 26587-26596 VBG denotes signaling
T19230 26597-26601 DT denotes that
T19231 26602-26607 MD denotes could
T19232 26608-26610 VB denotes be
T19233 26611-26617 VBN denotes shared
T19234 26618-26620 IN denotes by
T19235 26621-26626 JJ denotes other
T19236 26627-26636 NNS denotes pathogens
T19237 26636-26637 . denotes .
T19238 26638-26643 DT denotes These
T19239 26644-26648 NNS denotes data
T19240 26649-26656 VBP denotes provide
T19241 26657-26660 JJ denotes new
T19242 26661-26669 NNS denotes insights
T19243 26670-26674 IN denotes into
T19244 26675-26678 DT denotes the
T19245 26679-26685 RB denotes poorly
T19246 26686-26696 VBN denotes understood
T19247 26697-26703 NN denotes action
T19248 26704-26713 NN denotes mechanism
T19249 26714-26717 IN denotes for
T19250 26718-26722 JJS denotes most
T19251 26723-26727 CD denotes T3SS
T19252 26728-26737 NNS denotes effectors
T19253 26737-26738 . denotes .
T19254 26739-26744 CD denotes NleH1
T19255 26745-26755 VBZ denotes attenuates
T19256 26756-26759 DT denotes the
T19257 26760-26773 NN denotes transcription
T19258 26774-26776 IN denotes of
T19259 26777-26791 NN denotes RPS3-dependent
T19260 26791-26792 , denotes ,
T19261 26793-26796 CC denotes but
T19262 26797-26800 RB denotes not
T19263 26801-26804 DT denotes all
T19264 26804-26805 , denotes ,
T19265 26806-26811 JJ denotes NF-κB
T19266 26812-26818 NN denotes target
T19267 26819-26824 NNS denotes genes
T19268 26824-26825 , denotes ,
T19269 26826-26828 IN denotes in
T19270 26829-26839 JJ denotes particular
T19271 26840-26845 DT denotes those
T19272 26846-26851 NNS denotes genes
T19273 26852-26862 VBN denotes associated
T19274 26863-26867 IN denotes with
T19275 26868-26873 JJ denotes acute
T19276 26874-26889 JJ denotes proinflammatory
T19277 26890-26899 NNS denotes responses
T19278 26899-26900 , denotes ,
T19279 26901-26910 VBG denotes including
T19280 26911-26914 NNP denotes IL8
T19281 26915-26918 CC denotes and
T19282 26919-26922 NNP denotes TNF
T19283 26922-26923 . denotes .
T19284 26924-26926 IN denotes In
T19285 26927-26935 NN denotes contrast
T19286 26935-26936 , denotes ,
T19287 26937-26942 NNP denotes NleH1
T19288 26943-26947 VBZ denotes does
T19289 26948-26951 RB denotes not
T19290 26952-26957 VB denotes block
T19291 26958-26963 NNP denotes NF-κB
T19292 26964-26967 CD denotes p65
T19293 26968-26975 JJ denotes nuclear
T19294 26976-26989 NN denotes translocation
T19295 26989-26990 , denotes ,
T19296 26991-26996 WDT denotes which
T19297 26997-27005 VBZ denotes suggests
T19298 27006-27010 IN denotes that
T19299 27011-27018 JJ denotes certain
T19300 27019-27032 JJ denotes p65-dependent
T19301 27033-27036 CC denotes but
T19302 27037-27053 JJ denotes RPS3-independent
T19303 27054-27059 NN denotes NF-κB
T19304 27060-27066 NN denotes target
T19305 27067-27072 NNS denotes genes
T19306 27073-27078 MD denotes might
T19307 27079-27083 RB denotes thus
T19308 27084-27086 VB denotes be
T19309 27087-27097 JJ denotes beneficial
T19310 27098-27101 IN denotes for
T19311 27102-27104 NNP denotes E.
T19312 27105-27109 NNS denotes coli
T19313 27110-27114 NNP denotes O157
T19314 27114-27115 : denotes :
T19315 27115-27117 NNP denotes H7
T19316 27118-27120 TO denotes to
T19317 27121-27130 VB denotes replicate
T19318 27131-27134 CC denotes and
T19319 27135-27146 VB denotes disseminate
T19320 27147-27149 IN denotes in
T19321 27150-27153 DT denotes the
T19322 27154-27158 NN denotes host
T19323 27158-27159 . denotes .
T19324 27160-27162 IN denotes By
T19325 27163-27174 RB denotes selectively
T19326 27175-27185 VBG denotes inhibiting
T19327 27186-27190 CD denotes RPS3
T19328 27191-27194 CC denotes and
T19329 27195-27198 PRP$ denotes its
T19330 27199-27208 JJ denotes attendant
T19331 27209-27214 NN denotes NF-κB
T19332 27215-27223 NN denotes function
T19333 27224-27228 IN denotes with
T19334 27229-27234 NNP denotes NleH1
T19335 27234-27235 , denotes ,
T19336 27236-27239 DT denotes the
T19337 27240-27248 NN denotes pathogen
T19338 27249-27257 VBZ denotes achieves
T19339 27258-27261 DT denotes the
T19340 27262-27269 NN denotes ability
T19341 27270-27272 TO denotes to
T19342 27273-27281 VB denotes increase
T19343 27282-27294 NN denotes colonization
T19344 27295-27298 CC denotes and
T19345 27299-27307 NN denotes diarrhea
T19346 27308-27311 RB denotes yet
T19347 27312-27320 VBG denotes limiting
T19348 27321-27324 DT denotes the
T19349 27325-27334 NN denotes mortality
T19350 27335-27337 IN denotes of
T19351 27338-27341 DT denotes the
T19352 27342-27346 NN denotes host
T19353 27346-27347 . denotes .
T19354 27348-27352 DT denotes This
T19355 27353-27362 RB denotes seemingly
T19356 27363-27374 JJ denotes paradoxical
T19357 27375-27386 NN denotes combination
T19358 27387-27389 IN denotes of
T19359 27390-27397 NNS denotes effects
T19360 27398-27402 VBP denotes make
T19361 27403-27408 NN denotes sense
T19362 27409-27413 WRB denotes when
T19363 27414-27417 CD denotes one
T19364 27418-27427 VBZ denotes considers
T19365 27428-27432 IN denotes that
T19366 27433-27442 VBN denotes increased
T19367 27443-27452 JJ denotes bacterial
T19368 27453-27457 NN denotes load
T19369 27458-27461 CC denotes and
T19370 27462-27470 NN denotes diarrhea
T19371 27471-27479 RB denotes together
T19372 27480-27484 IN denotes with
T19373 27485-27493 NN denotes survival
T19374 27494-27496 IN denotes of
T19375 27497-27500 DT denotes the
T19376 27501-27509 JJ denotes infected
T19377 27510-27514 NN denotes host
T19378 27515-27520 MD denotes would
T19379 27521-27528 VB denotes promote
T19380 27529-27532 DT denotes the
T19381 27533-27542 VBG denotes spreading
T19382 27543-27545 IN denotes of
T19383 27546-27549 DT denotes the
T19384 27550-27558 NNS denotes bacteria
T19385 27559-27564 IN denotes among
T19386 27565-27566 DT denotes a
T19387 27567-27577 NN denotes population
T19388 27578-27580 IN denotes of
T19389 27581-27592 JJ denotes susceptible
T19390 27593-27604 NNS denotes individuals
T19391 27604-27605 . denotes .
T19392 27606-27610 JJ denotes Such
T19393 27611-27618 NN denotes complex
T19394 27619-27622 CC denotes and
T19395 27623-27634 JJ denotes paradoxical
T19396 27635-27647 JJ denotes pathological
T19397 27648-27655 NNS denotes effects
T19398 27656-27660 WDT denotes that
T19399 27661-27670 VBP denotes influence
T19400 27671-27674 DT denotes the
T19401 27675-27681 NN denotes spread
T19402 27682-27684 IN denotes of
T19403 27685-27692 NN denotes disease
T19404 27693-27696 VBP denotes are
T19405 27697-27702 RB denotes often
T19406 27703-27709 RB denotes poorly
T19407 27710-27720 VBN denotes understood
T19408 27721-27723 IN denotes at
T19409 27724-27727 DT denotes the
T19410 27728-27737 JJ denotes molecular
T19411 27738-27743 NN denotes level
T19412 27743-27744 . denotes .
T19413 27745-27748 PRP$ denotes Our
T19414 27749-27753 NNS denotes data
T19415 27754-27763 VB denotes elucidate
T19416 27764-27767 WRB denotes how
T19417 27768-27779 NNS denotes alterations
T19418 27780-27782 IN denotes in
T19419 27783-27792 JJ denotes selective
T19420 27793-27798 NN denotes NF-κB
T19421 27799-27807 NN denotes function
T19422 27807-27808 , denotes ,
T19423 27809-27817 VBN denotes achieved
T19424 27818-27820 IN denotes by
T19425 27821-27829 VBG denotes impeding
T19426 27830-27834 NNP denotes RPS3
T19427 27834-27835 , denotes ,
T19428 27836-27839 CC denotes but
T19429 27840-27843 RB denotes not
T19430 27844-27852 VBG denotes altering
T19431 27853-27856 CD denotes p65
T19432 27857-27864 JJ denotes nuclear
T19433 27865-27878 NN denotes translocation
T19434 27878-27879 , denotes ,
T19435 27880-27883 MD denotes can
T19436 27884-27893 VB denotes influence
T19437 27894-27902 JJ denotes specific
T19438 27903-27912 NNS denotes cytokines
T19439 27913-27917 WDT denotes that
T19440 27918-27924 VBP denotes affect
T19441 27925-27934 JJ denotes bacterial
T19442 27935-27947 NN denotes colonization
T19443 27947-27948 , denotes ,
T19444 27949-27957 NN denotes diarrhea
T19445 27958-27966 NNS denotes diseases
T19446 27967-27970 CC denotes and
T19447 27971-27980 NN denotes mortality
T19448 27980-27981 . denotes .
T19449 27982-27984 PRP denotes It
T19450 27985-27988 MD denotes may
T19451 27989-27991 VB denotes be
T19452 27992-28000 JJ denotes fruitful
T19453 28001-28003 IN denotes in
T19454 28004-28014 VBG denotes attempting
T19455 28015-28017 TO denotes to
T19456 28018-28028 VB denotes understand
T19457 28029-28034 JJ denotes other
T19458 28035-28045 JJ denotes infectious
T19459 28046-28049 CC denotes and
T19460 28050-28060 JJ denotes autoimmune
T19461 28061-28069 NNS denotes diseases
T19462 28070-28079 VBG denotes involving
T19463 28080-28085 NN denotes NF-κB
T19464 28086-28088 TO denotes to
T19465 28089-28097 VB denotes consider
T19466 28098-28107 JJ denotes selective
T19467 28108-28115 NNS denotes effects
T19468 28116-28118 IN denotes of
T19469 28119-28127 NNS denotes subunits
T19470 28128-28132 JJ denotes such
T19471 28133-28135 IN denotes as
T19472 28136-28140 CD denotes RPS3
T19473 28141-28143 IN denotes in
T19474 28144-28152 NN denotes addition
T19475 28153-28155 TO denotes to
T19476 28156-28162 JJ denotes global
T19477 28163-28168 NN denotes NF-κB
T19478 28169-28179 NN denotes inhibition
T19479 28179-28180 . denotes .
T20213 28191-28196 NNS denotes Cells
T20214 28197-28200 CC denotes and
T20215 28201-28209 NNP denotes Reagents
T20216 28210-28216 NNP denotes Jurkat
T20217 28217-28219 NNP denotes E6
T20218 28219-28221 CD denotes .1
T20219 28221-28222 , denotes ,
T20220 28223-28230 CD denotes HEK293T
T20221 28231-28234 CC denotes and
T20222 28235-28239 NNP denotes HeLa
T20223 28240-28245 NNS denotes cells
T20224 28246-28250 VBD denotes were
T20225 28251-28259 VBN denotes cultured
T20226 28260-28262 IN denotes in
T20227 28263-28267 NNP denotes RPMI
T20228 28268-28272 CD denotes 1640
T20229 28273-28276 CC denotes and
T20230 28277-28281 NNP denotes DMEM
T20231 28282-28294 VBD denotes supplemented
T20232 28295-28299 IN denotes with
T20233 28300-28302 CD denotes 10
T20234 28302-28303 NN denotes %
T20235 28304-28309 JJ denotes fetal
T20236 28310-28314 NN denotes calf
T20237 28315-28320 NN denotes serum
T20238 28320-28321 , denotes ,
T20239 28322-28323 CD denotes 2
T20240 28324-28326 NNP denotes mM
T20241 28327-28336 NN denotes glutamine
T20242 28336-28337 , denotes ,
T20243 28338-28341 CC denotes and
T20244 28342-28345 CD denotes 100
T20245 28346-28350 NNP denotes U/ml
T20246 28351-28355 DT denotes each
T20247 28356-28358 IN denotes of
T20248 28359-28369 NN denotes penicillin
T20249 28370-28373 CC denotes and
T20250 28374-28386 NN denotes streptomycin
T20251 28386-28387 , denotes ,
T20252 28388-28400 RB denotes respectively
T20253 28400-28401 . denotes .
T20254 28402-28406 NNP denotes IκBα
T20255 28407-28408 -LRB- denotes (
T20256 28408-28412 NNP denotes C-21
T20257 28412-28413 , denotes ,
T20258 28414-28420 JJ denotes sc-371
T20259 28420-28421 -RRB- denotes )
T20260 28421-28422 , denotes ,
T20261 28423-28426 NNS denotes p65
T20262 28427-28428 -LRB- denotes (
T20263 28428-28432 NN denotes C-20
T20264 28432-28433 , denotes ,
T20265 28434-28440 JJ denotes sc-372
T20266 28440-28441 -RRB- denotes )
T20267 28441-28442 , denotes ,
T20268 28443-28446 CC denotes and
T20269 28447-28464 NN denotes phospho-threonine
T20270 28465-28466 -LRB- denotes (
T20271 28466-28469 NN denotes H-2
T20272 28469-28470 , denotes ,
T20273 28471-28478 JJ denotes sc-5267
T20274 28478-28479 -RRB- denotes )
T20275 28480-28490 NNS denotes antibodies
T20276 28491-28495 VBD denotes were
T20277 28496-28500 IN denotes from
T20278 28501-28506 NNP denotes Santa
T20279 28507-28511 NNP denotes Cruz
T20280 28512-28525 NNP denotes Biotechnology
T20281 28525-28526 : denotes ;
T20282 28527-28534 NN denotes β-actin
T20283 28535-28536 -LRB- denotes (
T20284 28536-28541 NNP denotes AC-15
T20285 28541-28542 , denotes ,
T20286 28543-28548 NNP denotes A5441
T20287 28548-28549 -RRB- denotes )
T20288 28549-28550 , denotes ,
T20289 28551-28555 NNP denotes Flag
T20290 28556-28557 -LRB- denotes (
T20291 28557-28559 NNP denotes M2
T20292 28559-28560 , denotes ,
T20293 28561-28566 NNP denotes F3165
T20294 28566-28567 -RRB- denotes )
T20295 28567-28568 , denotes ,
T20296 28569-28571 NNP denotes HA
T20297 28572-28573 -LRB- denotes (
T20298 28573-28577 NNP denotes HA-7
T20299 28577-28578 , denotes ,
T20300 28579-28584 NNP denotes H3663
T20301 28584-28585 -RRB- denotes )
T20302 28585-28586 , denotes ,
T20303 28587-28597 JJ denotes importin-α
T20304 28598-28599 -LRB- denotes (
T20305 28599-28604 NN denotes IM-75
T20306 28604-28605 , denotes ,
T20307 28606-28611 NNP denotes I1784
T20308 28611-28612 -RRB- denotes )
T20309 28612-28613 , denotes ,
T20310 28614-28617 CC denotes and
T20311 28618-28628 JJ denotes importin-β
T20312 28629-28630 -LRB- denotes (
T20313 28630-28634 NNP denotes 31H4
T20314 28634-28635 , denotes ,
T20315 28636-28641 NNP denotes I2534
T20316 28641-28642 -RRB- denotes )
T20317 28643-28653 NNS denotes antibodies
T20318 28654-28658 VBD denotes were
T20319 28659-28663 IN denotes from
T20320 28664-28669 NNP denotes Sigma
T20321 28669-28670 : denotes ;
T20322 28671-28675 NNP denotes PARP
T20323 28676-28677 -LRB- denotes (
T20324 28677-28682 NNP denotes C2-10
T20325 28682-28683 , denotes ,
T20326 28684-28690 CD denotes 556362
T20327 28690-28691 -RRB- denotes )
T20328 28691-28692 , denotes ,
T20329 28693-28697 NNP denotes IKKα
T20330 28698-28699 -LRB- denotes (
T20331 28699-28704 NNP denotes B78-1
T20332 28704-28705 , denotes ,
T20333 28706-28712 CD denotes 556532
T20334 28712-28713 -RRB- denotes )
T20335 28713-28714 , denotes ,
T20336 28715-28718 CC denotes and
T20337 28719-28723 NNP denotes IKKβ
T20338 28724-28725 -LRB- denotes (
T20339 28725-28727 CD denotes 24
T20340 28727-28728 , denotes ,
T20341 28729-28735 CD denotes 611254
T20342 28735-28736 -RRB- denotes )
T20343 28737-28747 NNS denotes antibodies
T20344 28748-28752 VBD denotes were
T20345 28753-28757 IN denotes from
T20346 28758-28760 NNP denotes BD
T20347 28761-28771 NNP denotes Pharmingen
T20348 28771-28772 : denotes ;
T20349 28773-28777 NNP denotes CK2α
T20350 28778-28779 -LRB- denotes (
T20351 28779-28781 CD denotes 31
T20352 28781-28782 , denotes ,
T20353 28783-28789 CD denotes 611610
T20354 28789-28790 -RRB- denotes )
T20355 28791-28794 CC denotes and
T20356 28795-28800 NNP denotes Hsp90
T20357 28801-28802 -LRB- denotes (
T20358 28802-28804 CD denotes 68
T20359 28804-28805 , denotes ,
T20360 28806-28812 CD denotes 610418
T20361 28812-28813 -RRB- denotes )
T20362 28814-28824 NNS denotes antibodies
T20363 28825-28829 VBD denotes were
T20364 28830-28834 IN denotes from
T20365 28835-28837 NNP denotes BD
T20366 28838-28850 NNP denotes Transduction
T20367 28851-28863 NNPS denotes Laboratories
T20368 28863-28864 : denotes ;
T20369 28865-28877 NNP denotes phospho-IκBα
T20370 28878-28879 -LRB- denotes (
T20371 28879-28882 NNP denotes 5A5
T20372 28882-28883 , denotes ,
T20373 28884-28889 NNP denotes 9246S
T20374 28889-28890 -RRB- denotes )
T20375 28891-28894 CC denotes and
T20376 28895-28907 JJ denotes phospho-IKKα
T20377 28907-28908 NN denotes /
T20378 28908-28909 NN denotes β
T20379 28910-28911 -LRB- denotes (
T20380 28911-28915 NNP denotes 16A6
T20381 28915-28916 , denotes ,
T20382 28917-28922 NNP denotes 2697S
T20383 28922-28923 -RRB- denotes )
T20384 28924-28934 NNS denotes antibodies
T20385 28935-28939 VBD denotes were
T20386 28940-28944 IN denotes from
T20387 28945-28949 NNP denotes Cell
T20388 28950-28959 NNP denotes Signaling
T20389 28960-28970 NNP denotes Technology
T20390 28970-28971 : denotes ;
T20391 28972-28986 NN denotes phospho-serine
T20392 28987-28988 -LRB- denotes (
T20393 28988-28994 NNP denotes AB1603
T20394 28994-28995 -RRB- denotes )
T20395 28996-28999 CC denotes and
T20396 29000-29016 JJ denotes phospho-tyrosine
T20397 29017-29018 -LRB- denotes (
T20398 29018-29022 NNP denotes 4G10
T20399 29022-29023 , denotes ,
T20400 29024-29030 CD denotes 05-777
T20401 29030-29031 -RRB- denotes )
T20402 29032-29042 NNS denotes antibodies
T20403 29043-29047 VBD denotes were
T20404 29048-29052 IN denotes from
T20405 29053-29062 NNP denotes Millipore
T20406 29062-29063 . denotes .
T20407 29064-29067 DT denotes The
T20408 29068-29074 NN denotes rabbit
T20409 29075-29085 NN denotes polyclonal
T20410 29086-29090 NNP denotes RPS3
T20411 29091-29100 NN denotes antiserum
T20412 29101-29104 VBD denotes was
T20413 29105-29107 IN denotes as
T20414 29108-29117 VBN denotes described
T20415 29118-29129 NNS denotes previously6
T20416 29129-29130 . denotes .
T20417 29131-29134 DT denotes The
T20418 29135-29141 NN denotes rabbit
T20419 29142-29152 NN denotes polyclonal
T20420 29153-29161 NN denotes antibody
T20421 29162-29170 NN denotes specific
T20422 29171-29174 IN denotes for
T20423 29175-29179 NNP denotes S209
T20424 29180-29194 VBD denotes phosphorylated
T20425 29195-29199 CD denotes RPS3
T20426 29200-29203 VBD denotes was
T20427 29204-29213 VBN denotes generated
T20428 29214-29217 CC denotes and
T20429 29218-29226 NN denotes affinity
T20430 29227-29235 VBN denotes purified
T20431 29236-29238 IN denotes by
T20432 29239-29244 NNP denotes Primm
T20433 29245-29252 NNP denotes Biotech
T20434 29253-29258 VBG denotes using
T20435 29259-29262 DT denotes the
T20436 29263-29270 NN denotes peptide
T20437 29271-29283 NN denotes NH2-CKPLPDHV
T20438 29283-29284 -LRB- denotes (
T20439 29284-29286 NNP denotes Sp
T20440 29286-29287 -RRB- denotes )
T20441 29287-29295 NNP denotes IVE-COOH
T20442 29295-29296 . denotes .
T20635 29298-29305 NNP denotes Plasmid
T20636 29306-29316 NNP denotes Constructs
T20637 29317-29320 NNP denotes The
T20638 29321-29330 NNP denotes Flag-IKKβ
T20639 29331-29332 -LRB- denotes (
T20640 29332-29336 NNP denotes SSEE
T20641 29336-29337 -RRB- denotes )
T20642 29337-29338 , denotes ,
T20643 29339-29348 NNP denotes Flag-IKKβ
T20644 29349-29350 -LRB- denotes (
T20645 29350-29354 NNP denotes SSAA
T20646 29354-29355 -RRB- denotes )
T20647 29355-29356 , denotes ,
T20648 29357-29360 CC denotes and
T20649 29361-29368 NNP denotes HA-IκBα
T20650 29369-29370 -LRB- denotes (
T20651 29370-29374 NNP denotes SSAA
T20652 29374-29375 -RRB- denotes )
T20653 29376-29386 NNS denotes constructs
T20654 29387-29391 VBD denotes were
T20655 29392-29400 VBN denotes provided
T20656 29401-29403 IN denotes by
T20657 29404-29406 NNP denotes C.
T20658 29407-29409 NNP denotes Wu
T20659 29410-29411 -LRB- denotes (
T20660 29411-29414 NNP denotes NCI
T20661 29414-29415 , denotes ,
T20662 29416-29424 NNP denotes Bethesda
T20663 29424-29425 -RRB- denotes )
T20664 29426-29429 CC denotes and
T20665 29430-29432 NNP denotes U.
T20666 29433-29443 NNP denotes Siebenlist
T20667 29444-29445 -LRB- denotes (
T20668 29445-29450 NNP denotes NIAID
T20669 29450-29451 , denotes ,
T20670 29452-29460 NNP denotes Bethesda
T20671 29460-29461 -RRB- denotes )
T20672 29461-29462 , denotes ,
T20673 29463-29475 RB denotes respectively
T20674 29475-29476 . denotes .
T20675 29477-29480 DT denotes The
T20676 29481-29488 NNP denotes HA-IκBα
T20677 29489-29492 CC denotes and
T20678 29493-29497 NNP denotes IKKβ
T20679 29498-29499 -LRB- denotes (
T20680 29499-29503 NNP denotes K44A
T20681 29503-29504 -RRB- denotes )
T20682 29504-29505 : denotes -
T20683 29505-29509 NN denotes Flag
T20684 29510-29518 NNS denotes plasmids
T20685 29519-29523 VBD denotes were
T20686 29524-29533 VBN denotes purchased
T20687 29534-29538 IN denotes from
T20688 29539-29548 NNP denotes Addgene44
T20689 29548-29549 , denotes ,
T20690 29550-29552 CD denotes 45
T20691 29552-29553 . denotes .
T20692 29554-29557 DT denotes The
T20693 29558-29567 NN denotes Flag-RPS3
T20694 29567-29568 , denotes ,
T20695 29569-29577 NNP denotes GST-RPS3
T20696 29577-29578 , denotes ,
T20697 29579-29586 NNP denotes HA-RPS3
T20698 29586-29587 , denotes ,
T20699 29588-29593 NNP denotes VN-HA
T20700 29593-29594 , denotes ,
T20701 29595-29603 NNP denotes NleH1-HA
T20702 29604-29612 NNS denotes plasmids
T20703 29613-29617 VBD denotes were
T20704 29618-29627 VBN denotes described
T20705 29628-29639 CD denotes previously6
T20706 29639-29640 , denotes ,
T20707 29641-29642 CD denotes 9
T20708 29642-29643 . denotes .
T20709 29644-29647 DT denotes The
T20710 29648-29653 NN denotes point
T20711 29654-29661 NNS denotes mutants
T20712 29662-29664 IN denotes of
T20713 29665-29669 CD denotes RPS3
T20714 29670-29674 VBD denotes were
T20715 29675-29684 VBN denotes generated
T20716 29685-29687 IN denotes by
T20717 29688-29701 JJ denotes site-directed
T20718 29702-29713 NNS denotes mutagenesis
T20719 29714-29719 VBG denotes using
T20720 29720-29723 DT denotes the
T20721 29724-29729 NNP denotes Quick
T20722 29730-29736 NNP denotes Change
T20723 29737-29740 NNP denotes Kit
T20724 29741-29742 -LRB- denotes (
T20725 29742-29752 NNP denotes Stratagene
T20726 29752-29753 -RRB- denotes )
T20727 29754-29758 IN denotes with
T20728 29759-29766 NNS denotes primers
T20729 29767-29774 RB denotes forward
T20730 29775-29776 CD denotes 5
T20731 29776-29777 SYM denotes
T20732 29777-29778 : denotes -
T20733 29778-29813 NN denotes CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3
T20734 29813-29814 NN denotes
T20735 29815-29818 CC denotes and
T20736 29819-29826 VB denotes reverse
T20737 29827-29828 CD denotes 5
T20738 29828-29829 SYM denotes
T20739 29829-29830 : denotes -
T20740 29830-29865 NN denotes TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3
T20741 29865-29866 NN denotes
T20742 29867-29870 IN denotes for
T20743 29871-29876 NNP denotes S209A
T20744 29876-29877 . denotes .
T20745 29878-29881 DT denotes All
T20746 29882-29889 NNS denotes mutants
T20747 29890-29894 VBD denotes were
T20748 29895-29903 VBN denotes verified
T20749 29904-29906 IN denotes by
T20750 29907-29910 NNP denotes DNA
T20751 29911-29921 VBG denotes sequencing
T20752 29921-29922 . denotes .
T20907 29924-29927 CD denotes 32P
T20908 29928-29930 IN denotes in
T20909 29931-29935 NN denotes vivo
T20910 29936-29944 VBG denotes Labeling
T20911 29945-29948 NNP denotes HEK
T20912 29949-29953 CD denotes 293T
T20913 29954-29959 NNS denotes cells
T20914 29960-29964 VBD denotes were
T20915 29965-29972 VBN denotes labeled
T20916 29973-29977 IN denotes with
T20917 29978-29979 CD denotes 2
T20918 29980-29986 NNP denotes mCi/ml
T20919 29987-30005 NNP denotes 32P-orthophosphate
T20920 30006-30007 -LRB- denotes (
T20921 30007-30013 NNP denotes Perkin
T20922 30014-30019 NNP denotes Elmer
T20923 30019-30020 -RRB- denotes )
T20924 30021-30023 IN denotes in
T20925 30024-30038 JJ denotes phosphate-free
T20926 30039-30045 NN denotes medium
T20927 30046-30047 -LRB- denotes (
T20928 30047-30057 NNP denotes Invitrogen
T20929 30057-30058 -RRB- denotes )
T20930 30059-30062 IN denotes for
T20931 30063-30064 CD denotes 2
T20932 30065-30067 NN denotes h.
T20933 30068-30073 NNS denotes Cells
T20934 30074-30078 VBD denotes were
T20935 30079-30083 RB denotes then
T20936 30084-30088 VBN denotes left
T20937 30089-30098 JJ denotes untreated
T20938 30099-30101 CC denotes or
T20939 30102-30109 VBN denotes treated
T20940 30110-30114 IN denotes with
T20941 30115-30118 NNP denotes TNF
T20942 30119-30120 -LRB- denotes (
T20943 30120-30122 CD denotes 50
T20944 30123-30128 NN denotes ng/ml
T20945 30128-30129 , denotes ,
T20946 30130-30133 NNP denotes R&D
T20947 30134-30141 NNPS denotes Systems
T20948 30141-30142 -RRB- denotes )
T20949 30143-30146 IN denotes for
T20950 30147-30156 VBN denotes indicated
T20951 30157-30164 NNS denotes periods
T20952 30164-30165 . denotes .
T20953 30166-30170 NN denotes Cell
T20954 30171-30178 NNS denotes lysates
T20955 30179-30183 VBD denotes were
T20956 30184-30192 VBN denotes prepared
T20957 30193-30196 CC denotes and
T20958 30197-30201 VBN denotes used
T20959 30202-30205 IN denotes for
T20960 30206-30226 NNS denotes immunoprecipitations
T20961 30227-30231 IN denotes with
T20962 30232-30236 JJ denotes RPS3
T20963 30237-30245 NN denotes antibody
T20964 30245-30246 . denotes .
T21155 30248-30250 IN denotes In
T21156 30251-30256 NNP denotes Vitro
T21157 30257-30263 NNP denotes Kinase
T21158 30264-30269 NNP denotes Assay
T21159 30270-30283 JJ denotes Kinase-active
T21160 30284-30295 JJ denotes recombinant
T21161 30296-30300 NNP denotes IKKβ
T21162 30301-30304 CC denotes and
T21163 30305-30309 NNP denotes IKKα
T21164 30310-30318 NNS denotes proteins
T21165 30319-30323 VBD denotes were
T21166 30324-30333 VBN denotes purchased
T21167 30334-30338 IN denotes from
T21168 30339-30345 NNP denotes Active
T21169 30346-30351 NNP denotes Motif
T21170 30352-30355 CC denotes and
T21171 30356-30365 NNP denotes Millipore
T21172 30365-30366 , denotes ,
T21173 30367-30379 RB denotes respectively
T21174 30379-30380 . denotes .
T21175 30381-30392 RB denotes Bacterially
T21176 30393-30401 VBN denotes purified
T21177 30402-30413 NN denotes glutathione
T21178 30414-30427 NN denotes S-transferase
T21179 30428-30429 -LRB- denotes (
T21180 30429-30432 NNP denotes GST
T21181 30432-30433 -RRB- denotes )
T21182 30433-30434 , denotes ,
T21183 30435-30443 NNP denotes GST-IκBα
T21184 30444-30445 -LRB- denotes (
T21185 30445-30449 CD denotes 1-54
T21186 30449-30450 -RRB- denotes )
T21187 30450-30451 , denotes ,
T21188 30452-30456 JJ denotes wild
T21189 30457-30461 NN denotes type
T21190 30461-30462 , denotes ,
T21191 30463-30469 JJ denotes mutant
T21192 30470-30478 NN denotes GST-RPS3
T21193 30478-30479 , denotes ,
T21194 30480-30482 CC denotes or
T21195 30483-30487 CD denotes RPS3
T21196 30488-30496 NNS denotes proteins
T21197 30497-30501 VBD denotes were
T21198 30502-30506 VBN denotes used
T21199 30507-30509 IN denotes as
T21200 30510-30520 NNS denotes substrates
T21201 30520-30521 . denotes .
T21202 30522-30525 DT denotes The
T21203 30526-30528 IN denotes in
T21204 30529-30534 NN denotes vitro
T21205 30535-30541 NN denotes kinase
T21206 30542-30547 NN denotes assay
T21207 30548-30551 VBD denotes was
T21208 30552-30561 VBN denotes performed
T21209 30562-30564 IN denotes as
T21210 30565-30575 RB denotes previously
T21211 30576-30587 CD denotes described29
T21212 30587-30588 . denotes .
T21213 30589-30596 RB denotes Briefly
T21214 30596-30597 , denotes ,
T21215 30598-30604 NN denotes enzyme
T21216 30605-30606 -LRB- denotes (
T21217 30606-30609 CD denotes 100
T21218 30610-30612 NN denotes ng
T21219 30612-30613 -RRB- denotes )
T21220 30614-30617 CC denotes and
T21221 30618-30627 VB denotes substrate
T21222 30628-30629 -LRB- denotes (
T21223 30629-30630 CD denotes 2
T21224 30631-30633 NN denotes μg
T21225 30633-30634 -RRB- denotes )
T21226 30635-30639 VBD denotes were
T21227 30640-30652 VBN denotes co-incubated
T21228 30653-30655 IN denotes in
T21229 30656-30659 NNP denotes IKK
T21230 30660-30668 NN denotes reaction
T21231 30669-30675 NN denotes buffer
T21232 30676-30677 -LRB- denotes (
T21233 30677-30679 CD denotes 25
T21234 30680-30682 NNP denotes mM
T21235 30683-30687 NNP denotes Tris
T21236 30688-30691 NNP denotes HCl
T21237 30692-30693 NNP denotes [
T21238 30693-30695 NNP denotes pH
T21239 30696-30699 CD denotes 8.0
T21240 30699-30700 NNP denotes ]
T21241 30700-30701 , denotes ,
T21242 30702-30704 CD denotes 50
T21243 30705-30707 NNP denotes mM
T21244 30708-30711 NNP denotes KCl
T21245 30711-30712 , denotes ,
T21246 30713-30715 CD denotes 10
T21247 30716-30718 NNP denotes mM
T21248 30719-30724 NNP denotes MgCl2
T21249 30724-30725 , denotes ,
T21250 30726-30727 CD denotes 1
T21251 30728-30730 NNP denotes mM
T21252 30731-30734 NNP denotes DTT
T21253 30734-30735 , denotes ,
T21254 30736-30737 CD denotes 1
T21255 30738-30740 NNP denotes mM
T21256 30741-30747 NNP denotes Na3VO4
T21257 30747-30748 , denotes ,
T21258 30749-30750 CD denotes 1
T21259 30751-30753 NNP denotes mM
T21260 30754-30757 NNP denotes ATP
T21261 30757-30758 -RRB- denotes )
T21262 30759-30761 CC denotes or
T21263 30762-30767 JJ denotes NleH1
T21264 30768-30776 NN denotes reaction
T21265 30777-30783 NN denotes buffer
T21266 30784-30785 -LRB- denotes (
T21267 30785-30787 CD denotes 50
T21268 30788-30790 NNP denotes mM
T21269 30791-30799 NNP denotes Tris-HCl
T21270 30800-30801 NNP denotes [
T21271 30801-30803 NNP denotes pH
T21272 30804-30807 CD denotes 7.6
T21273 30807-30808 NNP denotes ]
T21274 30808-30809 , denotes ,
T21275 30810-30811 CD denotes 5
T21276 30812-30814 NNP denotes mM
T21277 30815-30820 NNP denotes MgCl2
T21278 30820-30821 , denotes ,
T21279 30822-30823 CD denotes 1
T21280 30824-30826 NNP denotes mM
T21281 30827-30830 NNP denotes DTT
T21282 30830-30831 , denotes ,
T21283 30832-30833 CD denotes 1
T21284 30834-30836 NNP denotes mM
T21285 30837-30840 NNP denotes ATP
T21286 30840-30841 -RRB- denotes )
T21287 30842-30846 IN denotes with
T21288 30847-30850 CD denotes 0.5
T21289 30851-30854 NNP denotes μCi
T21290 30855-30864 NNP denotes 32P-γ-ATP
T21291 30865-30866 -LRB- denotes (
T21292 30866-30868 NNP denotes GE
T21293 30869-30879 NNP denotes Healthcare
T21294 30879-30880 -RRB- denotes )
T21295 30881-30886 VBD denotes added
T21296 30887-30889 IN denotes at
T21297 30890-30892 CD denotes 37
T21298 30893-30894 CD denotes °
T21299 30894-30895 NNP denotes C
T21300 30896-30899 IN denotes for
T21301 30900-30902 CD denotes 30
T21302 30903-30906 NN denotes min
T21303 30906-30907 . denotes .
T21304 30908-30911 DT denotes The
T21305 30912-30921 NNS denotes reactions
T21306 30922-30926 VBD denotes were
T21307 30927-30935 VBN denotes resolved
T21308 30936-30938 IN denotes by
T21309 30939-30942 NNP denotes SDS
T21310 30943-30947 NNP denotes PAGE
T21311 30948-30951 CC denotes and
T21312 30952-30962 VBN denotes visualized
T21313 30963-30965 IN denotes by
T21314 30966-30981 NN denotes autoradiography
T21315 30981-30982 . denotes .
T21440 30984-30992 NNP denotes LC-MS/MS
T21441 30993-31001 NNP denotes Analysis
T21442 31002-31005 NNP denotes GST
T21443 31006-31008 CC denotes or
T21444 31009-31017 NNP denotes GST-RPS3
T21445 31018-31021 VBD denotes was
T21446 31022-31031 VBN denotes incubated
T21447 31032-31036 IN denotes with
T21448 31037-31048 JJ denotes recombinant
T21449 31049-31053 NNP denotes IKKβ
T21450 31054-31061 NN denotes protein
T21451 31062-31064 IN denotes as
T21452 31065-31074 VBN denotes described
T21453 31075-31080 IN denotes above
T21454 31081-31083 IN denotes in
T21455 31084-31086 DT denotes an
T21456 31087-31089 IN denotes in
T21457 31090-31095 NN denotes vitro
T21458 31096-31102 NN denotes kinase
T21459 31103-31108 NN denotes assay
T21460 31109-31117 NN denotes reaction
T21461 31118-31127 VBN denotes conducted
T21462 31128-31135 IN denotes without
T21463 31136-31145 NNP denotes 32P-γ-ATP
T21464 31146-31154 VBG denotes labeling
T21465 31154-31155 . denotes .
T21466 31156-31159 DT denotes The
T21467 31160-31168 NN denotes reaction
T21468 31169-31172 VBD denotes was
T21469 31173-31182 VBN denotes separated
T21470 31183-31185 IN denotes by
T21471 31186-31194 NNP denotes SDS-PAGE
T21472 31194-31195 , denotes ,
T21473 31196-31199 CC denotes and
T21474 31200-31203 DT denotes the
T21475 31204-31211 NN denotes protein
T21476 31212-31215 NN denotes gel
T21477 31216-31219 VBD denotes was
T21478 31220-31227 VBN denotes stained
T21479 31228-31232 IN denotes with
T21480 31233-31242 NNP denotes Colloidal
T21481 31243-31247 NNP denotes Blue
T21482 31248-31249 -LRB- denotes (
T21483 31249-31259 NNP denotes Invitrogen
T21484 31259-31260 -RRB- denotes )
T21485 31260-31261 . denotes .
T21486 31262-31265 DT denotes The
T21487 31266-31279 JJ denotes corresponding
T21488 31280-31287 NN denotes protein
T21489 31288-31297 NNS denotes fragments
T21490 31298-31302 VBD denotes were
T21491 31303-31310 VBN denotes excised
T21492 31311-31314 CC denotes and
T21493 31315-31324 VBN denotes subjected
T21494 31325-31327 TO denotes to
T21495 31328-31335 VB denotes trypsin
T21496 31336-31345 NN denotes digestion
T21497 31346-31349 CC denotes and
T21498 31350-31358 NN denotes LC-MS/MS
T21499 31359-31361 IN denotes at
T21500 31362-31365 DT denotes the
T21501 31366-31370 NNP denotes Yale
T21502 31371-31377 NNP denotes Cancer
T21503 31378-31384 NNP denotes Center
T21504 31385-31389 NNP denotes Mass
T21505 31390-31402 NNP denotes Spectrometry
T21506 31403-31411 NNP denotes Resource
T21507 31412-31413 -LRB- denotes (
T21508 31413-31416 NNP denotes New
T21509 31417-31422 NNP denotes Haven
T21510 31422-31423 , denotes ,
T21511 31424-31426 NNP denotes CT
T21512 31426-31427 -RRB- denotes )
T21513 31427-31428 . denotes .
T21602 31430-31434 NNS denotes RNAi
T21603 31435-31438 CC denotes and
T21604 31439-31451 NNP denotes Transfection
T21605 31452-31455 DT denotes The
T21606 31456-31461 NNP denotes siRNA
T21607 31462-31463 -LRB- denotes (
T21608 31463-31475 JJ denotes sense-strand
T21609 31476-31484 NN denotes sequence
T21610 31484-31485 -RRB- denotes )
T21611 31486-31490 NNP denotes IKKα
T21612 31490-31491 , denotes ,
T21613 31492-31493 CD denotes 5
T21614 31493-31494 SYM denotes
T21615 31494-31495 : denotes -
T21616 31495-31520 NNP denotes AUGACAGAGAAUGAUCAUGUUCUGC
T21617 31521-31523 CD denotes -3
T21618 31523-31524 NN denotes
T21619 31524-31525 : denotes ;
T21620 31526-31530 NNP denotes IKKβ
T21621 31530-31531 , denotes ,
T21622 31532-31533 CD denotes 5
T21623 31533-31534 SYM denotes
T21624 31534-31535 : denotes -
T21625 31535-31560 NNP denotes GCAGCAAGGAGAACAGAGGUUAAUA
T21626 31561-31563 CD denotes -3
T21627 31563-31564 NN denotes
T21628 31564-31565 : denotes ;
T21629 31566-31570 NNP denotes IκBα
T21630 31570-31571 , denotes ,
T21631 31572-31573 CD denotes 5
T21632 31573-31574 SYM denotes
T21633 31574-31575 : denotes -
T21634 31575-31600 NNP denotes GAGCUCCGAGACUUUCGAGGAAAUA
T21635 31601-31603 CD denotes -3
T21636 31603-31604 NN denotes
T21637 31604-31605 : denotes ;
T21638 31606-31612 NNP denotes RPS3-3
T21639 31612-31613 NNP denotes
T21640 31614-31617 NNP denotes UTR
T21641 31617-31618 , denotes ,
T21642 31619-31620 CD denotes 5
T21643 31620-31621 SYM denotes
T21644 31621-31622 : denotes -
T21645 31622-31643 NNP denotes GGAUGUUGCUCUCUAAAGACC
T21646 31644-31646 CD denotes -3
T21647 31646-31647 NN denotes
T21648 31648-31649 -LRB- denotes (
T21649 31649-31659 NNP denotes Invitrogen
T21650 31659-31660 -RRB- denotes )
T21651 31660-31661 . denotes .
T21652 31662-31671 JJ denotes Transient
T21653 31672-31684 NN denotes transfection
T21654 31685-31687 IN denotes of
T21655 31688-31693 NNP denotes siRNA
T21656 31694-31697 CC denotes and
T21657 31698-31701 NNP denotes DNA
T21658 31702-31712 VBZ denotes constructs
T21659 31713-31717 IN denotes into
T21660 31718-31724 NNP denotes Jurkat
T21661 31725-31730 NNS denotes cells
T21662 31731-31734 CC denotes and
T21663 31735-31739 JJ denotes 293T
T21664 31740-31745 NNS denotes cells
T21665 31746-31749 VBD denotes was
T21666 31750-31759 VBN denotes described
T21667 31760-31771 CD denotes previously6
T21668 31771-31772 . denotes .
T21863 31774-31785 NNP denotes Subcellular
T21864 31786-31799 NNP denotes Fractionation
T21865 31800-31811 NNP denotes Subcellular
T21866 31812-31825 NN denotes fractionation
T21867 31826-31829 VBD denotes was
T21868 31830-31839 VBN denotes performed
T21869 31840-31842 IN denotes by
T21870 31843-31855 JJ denotes differential
T21871 31856-31870 NN denotes centrifugation
T21872 31871-31873 IN denotes as
T21873 31874-31884 RB denotes previously
T21874 31885-31895 CD denotes described6
T21875 31895-31896 . denotes .
T21876 31897-31904 RB denotes Briefly
T21877 31904-31905 , denotes ,
T21878 31906-31911 NNS denotes cells
T21879 31912-31916 VBD denotes were
T21880 31917-31928 VBN denotes resuspended
T21881 31929-31931 IN denotes in
T21882 31932-31940 JJ denotes ice-cold
T21883 31941-31947 NNP denotes Buffer
T21884 31948-31949 NNP denotes A
T21885 31950-31951 -LRB- denotes (
T21886 31951-31953 CD denotes 10
T21887 31954-31956 NNP denotes mM
T21888 31957-31962 NNP denotes HEPES
T21889 31963-31965 NNP denotes pH
T21890 31966-31969 CD denotes 7.9
T21891 31969-31970 , denotes ,
T21892 31971-31973 CD denotes 10
T21893 31974-31976 NNP denotes mM
T21894 31977-31980 NNP denotes KCl
T21895 31980-31981 , denotes ,
T21896 31982-31985 CD denotes 1.5
T21897 31986-31988 NNP denotes mM
T21898 31989-31994 NNP denotes MgCl2
T21899 31994-31995 , denotes ,
T21900 31996-31999 CD denotes 0.1
T21901 32000-32002 NNP denotes mM
T21902 32003-32007 NNP denotes EDTA
T21903 32007-32008 , denotes ,
T21904 32009-32012 CD denotes 0.5
T21905 32013-32015 NNP denotes mM
T21906 32016-32019 NNP denotes DTT
T21907 32019-32020 , denotes ,
T21908 32021-32024 CD denotes 0.4
T21909 32025-32026 NN denotes %
T21910 32027-32032 NN denotes NP-40
T21911 32032-32033 , denotes ,
T21912 32034-32037 CD denotes 0.5
T21913 32038-32040 NNP denotes mM
T21914 32041-32045 NNP denotes PMSF
T21915 32045-32046 , denotes ,
T21916 32047-32055 JJ denotes complete
T21917 32056-32064 NN denotes protease
T21918 32065-32074 NN denotes inhibitor
T21919 32075-32083 NN denotes cocktail
T21920 32083-32084 -RRB- denotes )
T21921 32085-32087 IN denotes at
T21922 32088-32089 CD denotes 4
T21923 32090-32091 CD denotes °
T21924 32091-32092 NNP denotes C
T21925 32093-32096 IN denotes for
T21926 32097-32098 CD denotes 5
T21927 32099-32102 NN denotes min
T21928 32102-32103 . denotes .
T21929 32104-32111 NNS denotes Lysates
T21930 32112-32116 VBD denotes were
T21931 32117-32128 VBN denotes centrifuged
T21932 32129-32131 IN denotes at
T21933 32132-32133 CD denotes 4
T21934 32134-32135 CD denotes °
T21935 32135-32136 NNP denotes C
T21936 32136-32137 , denotes ,
T21937 32138-32141 CD denotes 500
T21938 32142-32143 NN denotes ×
T21939 32144-32145 NN denotes g
T21940 32146-32149 IN denotes for
T21941 32150-32151 CD denotes 3
T21942 32152-32155 NN denotes min
T21943 32155-32156 , denotes ,
T21944 32157-32160 CC denotes and
T21945 32161-32173 NNS denotes supernatants
T21946 32174-32178 VBD denotes were
T21947 32179-32188 VBN denotes collected
T21948 32189-32191 RB denotes as
T21949 32192-32201 JJ denotes cytosolic
T21950 32202-32211 NNS denotes fractions
T21951 32211-32212 . denotes .
T21952 32213-32220 NNS denotes Pellets
T21953 32221-32225 VBD denotes were
T21954 32226-32235 VBN denotes incubated
T21955 32236-32238 IN denotes in
T21956 32239-32245 NNP denotes Buffer
T21957 32246-32247 NNP denotes C
T21958 32248-32249 -LRB- denotes (
T21959 32249-32251 CD denotes 20
T21960 32252-32254 NNP denotes mM
T21961 32255-32260 NNP denotes HEPES
T21962 32261-32264 NNP denotes pH7
T21963 32264-32266 CD denotes .9
T21964 32266-32267 , denotes ,
T21965 32268-32271 CD denotes 420
T21966 32272-32274 NNP denotes mM
T21967 32275-32279 NNP denotes NaCl
T21968 32279-32280 , denotes ,
T21969 32281-32284 CD denotes 1.5
T21970 32285-32287 NNP denotes mM
T21971 32288-32293 NNP denotes MgCl2
T21972 32293-32294 , denotes ,
T21973 32295-32297 CD denotes 25
T21974 32297-32298 NN denotes %
T21975 32299-32307 NN denotes glycerol
T21976 32307-32308 , denotes ,
T21977 32309-32312 CD denotes 0.5
T21978 32313-32315 NNP denotes mM
T21979 32316-32320 NNP denotes PMSF
T21980 32320-32321 , denotes ,
T21981 32322-32325 CD denotes 0.2
T21982 32326-32328 NNP denotes mM
T21983 32329-32333 NNP denotes EDTA
T21984 32333-32334 , denotes ,
T21985 32335-32338 CD denotes 0.5
T21986 32339-32341 NNP denotes mM
T21987 32342-32345 NNP denotes DTT
T21988 32345-32346 , denotes ,
T21989 32347-32355 JJ denotes complete
T21990 32356-32364 NN denotes protease
T21991 32365-32374 NN denotes inhibitor
T21992 32375-32383 NN denotes cocktail
T21993 32383-32384 -RRB- denotes )
T21994 32385-32387 IN denotes at
T21995 32388-32389 CD denotes 4
T21996 32390-32391 CD denotes °
T21997 32391-32392 NNP denotes C
T21998 32393-32396 IN denotes for
T21999 32397-32399 CD denotes 10
T22000 32400-32403 NN denotes min
T22001 32403-32404 . denotes .
T22002 32405-32417 NNS denotes Supernatants
T22003 32418-32422 VBD denotes were
T22004 32423-32432 VBN denotes collected
T22005 32433-32435 IN denotes as
T22006 32436-32443 JJ denotes nuclear
T22007 32444-32453 NNS denotes fractions
T22008 32454-32463 VBG denotes following
T22009 32464-32465 DT denotes a
T22010 32466-32476 NN denotes centrifuge
T22011 32477-32479 IN denotes at
T22012 32480-32481 CD denotes 4
T22013 32482-32483 CD denotes °
T22014 32483-32484 NNP denotes C
T22015 32484-32485 , denotes ,
T22016 32486-32492 CD denotes 13,800
T22017 32493-32494 NN denotes ×
T22018 32495-32496 NN denotes g
T22019 32497-32500 IN denotes for
T22020 32501-32503 CD denotes 10
T22021 32504-32507 NN denotes min
T22022 32507-32508 . denotes .
T22111 32510-32520 NNP denotes Luciferase
T22112 32521-32529 NNP denotes Reporter
T22113 32530-32534 NNP denotes Gene
T22114 32535-32541 NNP denotes Assays
T22115 32542-32552 NNP denotes Luciferase
T22116 32553-32561 NN denotes reporter
T22117 32562-32566 NN denotes gene
T22118 32567-32573 NNS denotes assays
T22119 32574-32578 VBD denotes were
T22120 32579-32588 VBN denotes performed
T22121 32589-32591 IN denotes as
T22122 32592-32602 RB denotes previously
T22123 32603-32613 CD denotes described6
T22124 32613-32614 . denotes .
T22125 32615-32622 RB denotes Briefly
T22126 32622-32623 , denotes ,
T22127 32624-32629 NNS denotes cells
T22128 32630-32634 VBD denotes were
T22129 32635-32648 VBN denotes cotransfected
T22130 32649-32651 IN denotes at
T22131 32652-32653 DT denotes a
T22132 32654-32659 NN denotes ratio
T22133 32660-32662 IN denotes of
T22134 32663-32667 CD denotes 10:1
T22135 32668-32672 IN denotes with
T22136 32673-32680 JJ denotes various
T22137 32681-32696 JJ denotes promoter-driven
T22138 32697-32704 RB denotes firefly
T22139 32705-32715 JJ denotes luciferase
T22140 32716-32726 NNS denotes constructs
T22141 32727-32729 TO denotes to
T22142 32730-32733 DT denotes the
T22143 32734-32741 NNP denotes Renilla
T22144 32742-32752 NN denotes luciferase
T22145 32753-32758 NNP denotes pTKRL
T22146 32759-32766 NN denotes plasmid
T22147 32766-32767 , denotes ,
T22148 32768-32776 RB denotes together
T22149 32777-32781 IN denotes with
T22150 32782-32791 JJ denotes indicated
T22151 32792-32800 NNS denotes plasmids
T22152 32800-32801 . denotes .
T22153 32802-32807 NNS denotes Cells
T22154 32808-32812 VBD denotes were
T22155 32813-32821 VBN denotes cultured
T22156 32822-32825 IN denotes for
T22157 32826-32827 CD denotes 1
T22158 32828-32829 CD denotes 2
T22159 32830-32834 NNS denotes days
T22160 32835-32838 CC denotes and
T22161 32839-32843 RB denotes then
T22162 32844-32854 VBD denotes stimulated
T22163 32855-32857 IN denotes in
T22164 32858-32868 NN denotes triplicate
T22165 32869-32875 IN denotes before
T22166 32876-32883 NN denotes harvest
T22167 32883-32884 . denotes .
T22168 32885-32892 NNS denotes Lysates
T22169 32893-32897 VBD denotes were
T22170 32898-32906 VBN denotes analyzed
T22171 32907-32912 VBG denotes using
T22172 32913-32916 DT denotes the
T22173 32917-32932 NNP denotes Dual-Luciferase
T22174 32933-32936 NNP denotes Kit
T22175 32937-32938 -LRB- denotes (
T22176 32938-32945 NNP denotes Promega
T22177 32945-32946 -RRB- denotes )
T22178 32946-32947 . denotes .
T22257 32949-32958 NNP denotes Chromatin
T22258 32959-32978 NNP denotes Immunoprecipitation
T22259 32979-32980 -LRB- denotes (
T22260 32980-32984 NNP denotes ChIP
T22261 32984-32985 -RRB- denotes )
T22262 32986-32990 NNP denotes ChIP
T22263 32991-32997 NNS denotes assays
T22264 32998-33001 VBD denotes was
T22265 33002-33011 VBN denotes performed
T22266 33012-33014 IN denotes as
T22267 33015-33025 RB denotes previously
T22268 33026-33036 CD denotes described6
T22269 33036-33037 . denotes .
T22270 33038-33041 DT denotes The
T22271 33042-33049 NNS denotes primers
T22272 33050-33054 VBN denotes used
T22273 33055-33057 TO denotes to
T22274 33058-33065 VB denotes amplify
T22275 33066-33069 DT denotes the
T22276 33070-33078 NN denotes promoter
T22277 33079-33085 NN denotes region
T22278 33086-33094 JJ denotes adjacent
T22279 33095-33097 TO denotes to
T22280 33098-33101 DT denotes the
T22281 33102-33104 NN denotes κB
T22282 33105-33110 NNS denotes sites
T22283 33111-33113 IN denotes of
T22284 33114-33117 CD denotes IL8
T22285 33118-33121 CC denotes and
T22286 33122-33128 NNP denotes NFKBIA
T22287 33128-33129 , denotes ,
T22288 33130-33132 RB denotes as
T22289 33133-33137 RB denotes well
T22290 33138-33140 IN denotes as
T22291 33141-33145 NNP denotes ACTB
T22292 33146-33150 VBP denotes have
T22293 33151-33155 VBN denotes been
T22294 33156-33166 JJ denotes described6
T22295 33166-33167 . denotes .
T22423 33169-33187 NNP denotes Immunofluorescence
T22424 33188-33198 NNP denotes Microscopy
T22425 33199-33207 NNP denotes Confocal
T22426 33208-33218 NN denotes microscopy
T22427 33219-33222 VBD denotes was
T22428 33223-33232 VBN denotes performed
T22429 33233-33235 IN denotes as
T22430 33236-33246 RB denotes previously
T22431 33247-33257 CD denotes described6
T22432 33257-33258 . denotes .
T22433 33259-33266 RB denotes Briefly
T22434 33266-33267 , denotes ,
T22435 33268-33273 NNS denotes cells
T22436 33274-33278 VBD denotes were
T22437 33279-33284 VBN denotes fixed
T22438 33285-33289 IN denotes with
T22439 33290-33291 CD denotes 4
T22440 33292-33293 NN denotes %
T22441 33294-33310 NN denotes paraformaldehyde
T22442 33311-33313 IN denotes in
T22443 33314-33317 NNP denotes PBS
T22444 33318-33321 CC denotes and
T22445 33322-33326 RB denotes then
T22446 33327-33335 NNP denotes Cellspin
T22447 33336-33343 VBD denotes mounted
T22448 33344-33348 IN denotes onto
T22449 33349-33355 NNS denotes slides
T22450 33355-33356 . denotes .
T22451 33357-33360 DT denotes The
T22452 33361-33366 JJ denotes fixed
T22453 33367-33372 NNS denotes cells
T22454 33373-33377 VBD denotes were
T22455 33378-33382 RB denotes then
T22456 33383-33396 VBN denotes permeabilized
T22457 33397-33401 IN denotes with
T22458 33402-33406 CD denotes 0.05
T22459 33407-33408 NN denotes %
T22460 33409-33415 NNP denotes Triton
T22461 33416-33421 NNP denotes X-100
T22462 33422-33424 IN denotes in
T22463 33425-33428 NNP denotes PBS
T22464 33429-33432 CC denotes and
T22465 33433-33440 VBN denotes stained
T22466 33441-33445 IN denotes with
T22467 33446-33461 JJ denotes FITC-conjugated
T22468 33462-33468 NN denotes rabbit
T22469 33469-33478 JJ denotes anti-RPS3
T22470 33479-33489 NNS denotes antibodies
T22471 33490-33491 -LRB- denotes (
T22472 33491-33496 NNP denotes Primm
T22473 33497-33504 NNP denotes Biotech
T22474 33504-33505 -RRB- denotes )
T22475 33505-33506 , denotes ,
T22476 33507-33509 CC denotes or
T22477 33510-33520 NNP denotes AlexaFluor
T22478 33521-33535 JJ denotes 594-conjugated
T22479 33536-33539 NN denotes rat
T22480 33540-33549 JJ denotes anti-Flag
T22481 33550-33560 NNS denotes antibodies
T22482 33561-33562 -LRB- denotes (
T22483 33562-33564 NNP denotes BD
T22484 33564-33565 -RRB- denotes )
T22485 33566-33569 IN denotes for
T22486 33570-33572 CD denotes 40
T22487 33573-33576 NN denotes min
T22488 33577-33585 RB denotes together
T22489 33586-33590 IN denotes with
T22490 33591-33592 CD denotes 1
T22491 33593-33595 NN denotes μg
T22492 33595-33596 NN denotes /
T22493 33596-33598 NN denotes ml
T22494 33599-33601 IN denotes of
T22495 33602-33609 NNP denotes Hoechst
T22496 33610-33615 CD denotes 33342
T22497 33616-33617 -LRB- denotes (
T22498 33617-33622 NNP denotes Sigma
T22499 33622-33623 -RRB- denotes )
T22500 33624-33627 IN denotes for
T22501 33628-33629 CD denotes 5
T22502 33630-33633 NN denotes min
T22503 33634-33636 IN denotes at
T22504 33637-33639 CD denotes 25
T22505 33640-33641 CD denotes °
T22506 33641-33642 NNP denotes C
T22507 33642-33643 . denotes .
T22508 33644-33647 DT denotes The
T22509 33648-33654 NNS denotes slides
T22510 33655-33659 VBD denotes were
T22511 33660-33664 RB denotes then
T22512 33665-33671 VBN denotes rinsed
T22513 33672-33676 IN denotes with
T22514 33677-33680 NNP denotes PBS
T22515 33681-33686 CD denotes three
T22516 33687-33692 NNS denotes times
T22517 33693-33696 CC denotes and
T22518 33697-33702 VB denotes cover
T22519 33703-33710 VBN denotes mounted
T22520 33711-33714 IN denotes for
T22521 33715-33727 NN denotes fluorescence
T22522 33728-33738 NN denotes microscopy
T22523 33738-33739 . denotes .
T22801 33741-33760 NNP denotes Immunoprecipitation
T22802 33761-33764 CC denotes and
T22803 33765-33775 JJ denotes immunoblot
T22804 33776-33779 DT denotes The
T22805 33780-33785 NNS denotes cells
T22806 33786-33790 VBD denotes were
T22807 33791-33800 VBN denotes harvested
T22808 33801-33804 CC denotes and
T22809 33805-33810 VBN denotes lysed
T22810 33811-33813 IN denotes on
T22811 33814-33817 NN denotes ice
T22812 33818-33820 IN denotes by
T22813 33821-33824 CD denotes 0.4
T22814 33825-33827 NN denotes ml
T22815 33828-33830 IN denotes of
T22816 33831-33834 DT denotes the
T22817 33835-33843 VBN denotes modified
T22818 33844-33848 NNP denotes RIPA
T22819 33849-33855 NN denotes buffer
T22820 33856-33857 -LRB- denotes (
T22821 33857-33859 CD denotes 50
T22822 33860-33862 NNP denotes mM
T22823 33863-33871 NNP denotes Tris-HCl
T22824 33872-33873 NNP denotes [
T22825 33873-33875 NNP denotes pH
T22826 33876-33879 CD denotes 7.4
T22827 33879-33880 NNP denotes ]
T22828 33880-33881 , denotes ,
T22829 33882-33883 CD denotes 1
T22830 33883-33884 NN denotes %
T22831 33885-33890 NN denotes NP-40
T22832 33890-33891 , denotes ,
T22833 33892-33896 CD denotes 0.25
T22834 33896-33897 NN denotes %
T22835 33898-33913 JJ denotes Na-deoxycholate
T22836 33913-33914 , denotes ,
T22837 33915-33918 CD denotes 150
T22838 33919-33921 NNP denotes mM
T22839 33922-33926 NNP denotes NaCl
T22840 33926-33927 , denotes ,
T22841 33928-33929 CD denotes 1
T22842 33930-33932 NNP denotes mM
T22843 33933-33937 NNP denotes EDTA
T22844 33937-33938 , denotes ,
T22845 33939-33940 CD denotes 1
T22846 33941-33943 NNP denotes mM
T22847 33944-33948 NNP denotes PMSF
T22848 33948-33949 , denotes ,
T22849 33950-33951 CD denotes 1
T22850 33952-33954 NNP denotes mM
T22851 33955-33961 NNP denotes Na3VO4
T22852 33961-33962 , denotes ,
T22853 33963-33964 CD denotes 1
T22854 33965-33967 NNP denotes mM
T22855 33968-33971 NNP denotes NaF
T22856 33971-33972 -RRB- denotes )
T22857 33973-33985 VBN denotes supplemented
T22858 33986-33990 IN denotes with
T22859 33991-33992 CD denotes 1
T22860 33993-33994 CD denotes ×
T22861 33995-34003 NN denotes protease
T22862 34004-34013 NN denotes inhibitor
T22863 34014-34022 NN denotes cocktail
T22864 34023-34024 -LRB- denotes (
T22865 34024-34029 NNP denotes Roche
T22866 34029-34030 -RRB- denotes )
T22867 34031-34034 CC denotes and
T22868 34035-34036 CD denotes 1
T22869 34037-34038 CD denotes ×
T22870 34039-34050 NN denotes phosphatase
T22871 34051-34060 NN denotes inhibitor
T22872 34061-34069 NN denotes cocktail
T22873 34070-34073 VBN denotes set
T22874 34074-34075 PRP denotes I
T22875 34076-34077 -LRB- denotes (
T22876 34077-34080 NNP denotes EMD
T22877 34081-34092 NNPS denotes Biosciences
T22878 34092-34093 -RRB- denotes )
T22879 34094-34097 IN denotes for
T22880 34098-34100 CD denotes 30
T22881 34101-34104 NN denotes min
T22882 34104-34105 . denotes .
T22883 34106-34109 DT denotes The
T22884 34110-34117 NNS denotes lysates
T22885 34118-34122 VBD denotes were
T22886 34123-34134 VBN denotes centrifuged
T22887 34135-34137 IN denotes at
T22888 34138-34144 CD denotes 10,000
T22889 34145-34146 CD denotes ×
T22890 34147-34148 NN denotes g
T22891 34149-34151 IN denotes at
T22892 34152-34153 CD denotes 4
T22893 34154-34155 CD denotes °
T22894 34155-34156 NNP denotes C
T22895 34157-34160 IN denotes for
T22896 34161-34163 CD denotes 10
T22897 34164-34167 NN denotes min
T22898 34168-34170 TO denotes to
T22899 34171-34177 VB denotes remove
T22900 34178-34187 JJ denotes insoluble
T22901 34188-34196 NN denotes material
T22902 34196-34197 . denotes .
T22903 34198-34203 IN denotes After
T22904 34204-34215 VBG denotes normalizing
T22905 34216-34223 NN denotes protein
T22906 34224-34238 NNS denotes concentrations
T22907 34238-34239 , denotes ,
T22908 34240-34247 NNS denotes lysates
T22909 34248-34252 VBD denotes were
T22910 34253-34262 VBN denotes subjected
T22911 34263-34265 TO denotes to
T22912 34266-34285 NN denotes immunoprecipitation
T22913 34286-34288 IN denotes by
T22914 34289-34295 VBG denotes adding
T22915 34296-34298 CD denotes 10
T22916 34299-34304 JJ denotes mg/ml
T22917 34305-34316 JJ denotes appropriate
T22918 34317-34325 NN denotes antibody
T22919 34326-34330 CC denotes plus
T22920 34331-34333 CD denotes 30
T22921 34334-34336 NN denotes ml
T22922 34337-34339 IN denotes of
T22923 34340-34347 NN denotes protein
T22924 34348-34357 NN denotes G-agarose
T22925 34358-34359 -LRB- denotes (
T22926 34359-34364 NNP denotes Roche
T22927 34364-34365 -RRB- denotes )
T22928 34365-34366 , denotes ,
T22929 34367-34370 CC denotes and
T22930 34371-34378 VBD denotes rotated
T22931 34379-34382 IN denotes for
T22932 34383-34385 IN denotes at
T22933 34386-34391 JJS denotes least
T22934 34392-34393 CD denotes 2
T22935 34394-34395 NN denotes h
T22936 34396-34398 IN denotes at
T22937 34399-34400 CD denotes 4
T22938 34400-34401 CD denotes °
T22939 34401-34402 NNP denotes C
T22940 34402-34403 . denotes .
T22941 34404-34407 DT denotes The
T22942 34408-34420 NNS denotes precipitates
T22943 34421-34425 VBD denotes were
T22944 34426-34432 VBN denotes washed
T22945 34433-34435 IN denotes at
T22946 34436-34441 JJS denotes least
T22947 34442-34446 CD denotes five
T22948 34447-34452 NNS denotes times
T22949 34453-34457 IN denotes with
T22950 34458-34462 JJ denotes cold
T22951 34463-34468 NN denotes lysis
T22952 34469-34475 NN denotes buffer
T22953 34476-34484 VBN denotes followed
T22954 34485-34487 IN denotes by
T22955 34488-34498 NN denotes separation
T22956 34499-34501 IN denotes by
T22957 34502-34510 NNP denotes SDS-PAGE
T22958 34511-34516 IN denotes under
T22959 34517-34524 VBN denotes reduced
T22960 34525-34528 CC denotes and
T22961 34529-34539 VBG denotes denaturing
T22962 34540-34550 NNS denotes conditions
T22963 34550-34551 . denotes .
T22964 34552-34566 NNP denotes Nitrocellulose
T22965 34567-34576 NNS denotes membranes
T22966 34577-34581 VBD denotes were
T22967 34582-34589 VBN denotes blocked
T22968 34590-34592 IN denotes in
T22969 34593-34594 CD denotes 5
T22970 34595-34596 NN denotes %
T22971 34597-34603 JJ denotes nonfat
T22972 34604-34608 NN denotes milk
T22973 34609-34611 IN denotes in
T22974 34612-34615 CD denotes 0.1
T22975 34616-34617 NN denotes %
T22976 34618-34627 JJ denotes PBS-Tween
T22977 34628-34630 CD denotes 20
T22978 34631-34632 -LRB- denotes (
T22979 34632-34637 NN denotes PBS-T
T22980 34637-34638 -RRB- denotes )
T22981 34638-34639 , denotes ,
T22982 34640-34646 VBN denotes probed
T22983 34647-34651 IN denotes with
T22984 34652-34660 JJ denotes specific
T22985 34661-34671 NNS denotes antibodies
T22986 34672-34674 IN denotes as
T22987 34675-34684 VBN denotes described
T22988 34685-34696 NNS denotes previously6
T22989 34696-34697 . denotes .
T22990 34698-34701 IN denotes For
T22991 34702-34716 VBG denotes immunoblotting
T22992 34717-34719 IN denotes of
T22993 34720-34734 JJ denotes phosphorylated
T22994 34735-34743 NNS denotes proteins
T22995 34743-34744 , denotes ,
T22996 34745-34749 NNS denotes gels
T22997 34750-34754 VBD denotes were
T22998 34755-34766 VBN denotes transferred
T22999 34767-34769 TO denotes to
T23000 34770-34786 JJ denotes methanol-treated
T23001 34787-34801 NN denotes polyvinylidene
T23002 34802-34810 NN denotes chloride
T23003 34811-34820 NNS denotes membranes
T23004 34820-34821 , denotes ,
T23005 34822-34831 VBD denotes retreated
T23006 34832-34836 IN denotes with
T23007 34837-34845 NN denotes methanol
T23008 34845-34846 , denotes ,
T23009 34847-34850 CC denotes and
T23010 34851-34856 VBD denotes dried
T23011 34857-34860 IN denotes for
T23012 34861-34863 CD denotes 30
T23013 34864-34867 NN denotes min
T23014 34867-34868 . denotes .
T23015 34869-34874 NNS denotes Blots
T23016 34875-34879 VBD denotes were
T23017 34880-34887 VBN denotes blocked
T23018 34888-34890 IN denotes in
T23019 34891-34892 CD denotes 5
T23020 34893-34894 NN denotes %
T23021 34895-34901 JJ denotes bovine
T23022 34902-34907 NN denotes serum
T23023 34908-34915 NN denotes albumin
T23024 34916-34918 IN denotes in
T23025 34919-34922 CD denotes 0.1
T23026 34923-34924 NN denotes %
T23027 34925-34929 NNP denotes Tris
T23028 34930-34938 VBD denotes buffered
T23029 34939-34951 JJ denotes saline-Tween
T23030 34952-34954 CD denotes 20
T23031 34955-34956 -LRB- denotes (
T23032 34956-34961 NN denotes TBS-T
T23033 34961-34962 -RRB- denotes )
T23034 34962-34963 , denotes ,
T23035 34964-34967 CC denotes and
T23036 34968-34974 VBD denotes probed
T23037 34975-34979 IN denotes with
T23038 34980-34988 JJ denotes specific
T23039 34989-34999 NNS denotes antibodies
T23040 35000-35002 IN denotes as
T23041 35003-35012 VBN denotes described
T23042 35013-35025 NNS denotes previously46
T23043 35025-35026 . denotes .
T23044 35027-35032 NNS denotes Bands
T23045 35033-35037 VBD denotes were
T23046 35038-35044 VBN denotes imaged
T23047 35045-35047 IN denotes by
T23048 35048-35051 DT denotes the
T23049 35052-35057 NNP denotes Super
T23050 35058-35067 VBG denotes Signaling
T23051 35068-35074 NN denotes system
T23052 35075-35076 -LRB- denotes (
T23053 35076-35082 NNP denotes Pierce
T23054 35082-35083 -RRB- denotes )
T23055 35084-35093 VBG denotes according
T23056 35094-35096 TO denotes to
T23057 35097-35100 DT denotes the
T23058 35101-35113 NN denotes manufacturer
T23059 35113-35115 POS denotes 's
T23060 35116-35128 NNS denotes instructions
T23061 35128-35129 . denotes .
T23138 35131-35136 NNP denotes ELISA
T23139 35137-35140 DT denotes The
T23140 35141-35147 NN denotes amount
T23141 35148-35150 IN denotes of
T23142 35151-35155 NN denotes IL-8
T23143 35156-35163 NN denotes present
T23144 35164-35166 IN denotes in
T23145 35167-35179 NNS denotes supernatants
T23146 35180-35189 VBN denotes collected
T23147 35190-35194 IN denotes from
T23148 35195-35201 NNP denotes Jurkat
T23149 35202-35206 NN denotes cell
T23150 35207-35214 NN denotes culture
T23151 35215-35218 VBD denotes was
T23152 35219-35227 VBN denotes measured
T23153 35228-35233 VBG denotes using
T23154 35234-35235 DT denotes a
T23155 35236-35241 JJ denotes Human
T23156 35242-35255 NN denotes Interleukin-8
T23157 35256-35261 NNP denotes ELISA
T23158 35262-35274 NNP denotes Ready-SET-Go
T23159 35275-35278 NN denotes kit
T23160 35279-35280 -LRB- denotes (
T23161 35280-35291 NNP denotes eBioscience
T23162 35291-35292 -RRB- denotes )
T23163 35293-35302 VBG denotes according
T23164 35303-35305 TO denotes to
T23165 35306-35309 DT denotes the
T23166 35310-35322 NN denotes manufacturer
T23167 35322-35324 POS denotes 's
T23168 35325-35337 NNS denotes instructions
T23169 35337-35338 . denotes .
T23214 35340-35344 NNP denotes Cell
T23215 35345-35355 NNP denotes Infections
T23216 35356-35360 NNP denotes HeLa
T23217 35361-35366 NNS denotes cells
T23218 35367-35371 VBD denotes were
T23219 35372-35380 VBN denotes infected
T23220 35381-35385 IN denotes with
T23221 35386-35388 NNP denotes E.
T23222 35389-35393 NNS denotes coli
T23223 35394-35398 NNP denotes O157
T23224 35398-35399 : denotes :
T23225 35399-35401 NNP denotes H7
T23226 35402-35404 CC denotes or
T23227 35405-35407 NNP denotes C.
T23228 35408-35417 NN denotes rodentium
T23229 35418-35425 NNS denotes strains
T23230 35426-35428 IN denotes as
T23231 35429-35438 VBN denotes described
T23232 35439-35450 CD denotes previously9
T23233 35450-35451 . denotes .
T23283 35453-35473 NNP denotes Immunohistochemistry
T23284 35474-35485 NNP denotes Gnotobiotic
T23285 35486-35493 NNS denotes piglets
T23286 35494-35498 VBD denotes were
T23287 35499-35507 VBN denotes infected
T23288 35508-35512 IN denotes with
T23289 35513-35515 NNP denotes E.
T23290 35516-35520 NNS denotes coli
T23291 35521-35525 NNP denotes O157
T23292 35525-35526 : denotes :
T23293 35526-35528 NNP denotes H7
T23294 35529-35536 NNS denotes strains
T23295 35537-35539 IN denotes as
T23296 35540-35549 VBN denotes described
T23297 35550-35561 CD denotes previously9
T23298 35561-35562 . denotes .
T23299 35563-35569 NN denotes Spiral
T23300 35570-35575 NN denotes colon
T23301 35576-35585 NNS denotes specimens
T23302 35586-35590 VBD denotes were
T23303 35591-35600 VBN denotes collected
T23304 35601-35603 IN denotes at
T23305 35604-35612 NN denotes necropsy
T23306 35613-35616 CC denotes and
T23307 35617-35625 VBN denotes embedded
T23308 35626-35628 IN denotes in
T23309 35629-35637 NN denotes paraffin
T23310 35637-35638 . denotes .
T23311 35639-35647 NNP denotes Paraffin
T23312 35648-35658 NN denotes sectioning
T23313 35659-35662 CC denotes and
T23314 35663-35682 JJ denotes immunohistochemical
T23315 35683-35691 NN denotes staining
T23316 35692-35697 VBG denotes using
T23317 35698-35710 JJ denotes phospho-RPS3
T23318 35711-35719 NN denotes antibody
T23319 35720-35724 VBD denotes were
T23320 35725-35734 VBN denotes performed
T23321 35735-35737 IN denotes by
T23322 35738-35747 NNP denotes Histoserv
T23323 35748-35752 NNP denotes Inc.
T250 0-4 NNP denotes IKKβ
T251 5-20 NN denotes phosphorylation
T252 21-30 VBZ denotes regulates
T253 31-35 CD denotes RPS3
T254 36-43 JJ denotes nuclear
T255 44-57 NN denotes translocation
T256 58-61 CC denotes and
T257 62-67 JJ denotes NF-κB
T258 68-76 NN denotes function
T259 77-95 NNP denotes during Escherichia
T260 96-105 NNP denotes coli O157
T261 105-106 : denotes :
T262 106-108 NNP denotes H7
T263 109-118 NN denotes infection
T264 130-135 NN denotes NF-κB
T265 136-138 VBZ denotes is
T266 139-140 DT denotes a
T267 141-146 JJ denotes major
T268 147-151 NN denotes gene
T269 152-161 NN denotes regulator
T270 162-164 IN denotes in
T271 165-171 JJ denotes immune
T272 172-181 NNS denotes responses
T273 182-185 CC denotes and
T274 186-195 JJ denotes ribosomal
T275 196-203 NN denotes protein
T276 204-206 NNP denotes S3
T277 207-208 -LRB- denotes (
T278 208-212 NNP denotes RPS3
T279 212-213 -RRB- denotes )
T280 214-216 VBZ denotes is
T281 217-219 DT denotes an
T282 220-225 JJ denotes NF-κB
T283 226-233 NN denotes subunit
R228 T294 T298 amod unknown,translocation
R229 T295 T296 advmod how,RPS3
R230 T296 T298 amod RPS3,translocation
R231 T297 T298 amod nuclear,translocation
R232 T298 T300 nsubjpass translocation,regulated
R233 T299 T300 auxpass is,regulated
R234 T300 T293 ccomp regulated,is
R235 T301 T293 punct .,is
R236 T302 T304 advmod Here,report
R237 T303 T304 nsubj we,report
R238 T304 T304 ROOT report,report
R239 T305 T314 mark that,was
R240 T306 T307 compound IKKβ,phosphorylation
R241 T307 T314 nsubj phosphorylation,was
R242 T308 T307 prep of,phosphorylation
R243 T309 T308 pobj serine,of
R244 T310 T309 nummod 209,serine
R245 T311 T309 punct (,serine
R246 T312 T309 appos S209,serine
R247 T313 T309 punct ),serine
R248 T314 T304 ccomp was,report
R249 T315 T314 acomp crucial,was
R250 T316 T315 prep for,crucial
R251 T317 T319 amod RPS3,localization
R252 T318 T319 amod nuclear,localization
R253 T319 T316 pobj localization,for
R254 T320 T319 prep in,localization
R255 T321 T320 pobj response,in
R256 T322 T321 prep to,response
R257 T323 T322 pcomp activating,to
R258 T324 T323 dobj stimuli,activating
R259 T325 T304 punct .,report
R260 T326 T340 advmod Moreover,inhibited
R261 T327 T340 punct ",",inhibited
R262 T328 T330 det the,pathogen
R263 T329 T330 compound foodborne,pathogen
R264 T330 T340 nsubj pathogen,inhibited
R265 T331 T332 compound Escherichia,coli
R266 T332 T333 compound coli,O157
R267 T333 T330 appos O157,pathogen
R268 T334 T333 punct :,O157
R269 T335 T337 compound H7,protein
R270 T336 T337 compound virulence,protein
R271 T337 T330 conj protein,pathogen
R272 T338 T340 nsubj NleH1,inhibited
R273 T339 T340 advmod specifically,inhibited
R274 T340 T340 ROOT inhibited,inhibited
R275 T341 T343 compound RPS3,phosphorylation
R276 T342 T343 compound S209,phosphorylation
R277 T343 T340 dobj phosphorylation,inhibited
R278 T344 T340 cc and,inhibited
R279 T345 T340 conj blocked,inhibited
R280 T346 T347 nummod RPS3,function
R281 T347 T345 dobj function,blocked
R282 T348 T345 punct ",",blocked
R283 T349 T350 advmod thereby,promoting
R284 T350 T345 advcl promoting,blocked
R285 T351 T352 amod bacterial,colonization
R286 T352 T350 dobj colonization,promoting
R287 T353 T352 cc and,colonization
R288 T354 T352 conj diarrhea,colonization
R289 T355 T350 cc but,promoting
R290 T356 T350 conj decreasing,promoting
R291 T357 T356 dobj mortality,decreasing
R292 T358 T356 prep in,decreasing
R293 T359 T363 det a,model
R294 T360 T363 amod gnotobiotic,model
R295 T361 T363 compound piglet,model
R296 T362 T363 compound infection,model
R297 T363 T358 pobj model,in
R298 T364 T340 punct .,inhibited
R299 T365 T377 advmod Thus,promotes
R300 T366 T377 punct ",",promotes
R301 T367 T369 det the,modification
R302 T368 T369 amod IKKβ-dependent,modification
R303 T369 T377 nsubj modification,promotes
R304 T370 T369 prep of,modification
R305 T371 T374 det a,acid
R306 T372 T374 amod specific,acid
R307 T373 T374 compound amino,acid
R308 T374 T370 pobj acid,of
R309 T375 T369 prep in,modification
R310 T376 T375 pobj RPS3,in
R311 T377 T377 ROOT promotes,promotes
R312 T378 T380 amod specific,functions
R313 T379 T380 amod NF-κB,functions
R314 T380 T377 dobj functions,promotes
R315 T381 T382 nsubj that,underlie
R316 T382 T380 relcl underlie,functions
R317 T383 T386 det the,mechanisms
R318 T384 T386 amod molecular,mechanisms
R319 T385 T386 amod pathogenetic,mechanisms
R320 T386 T382 dobj mechanisms,underlie
R321 T387 T386 prep of,mechanisms
R322 T388 T390 compound E.,O157
R323 T389 T390 compound coli,O157
R324 T390 T387 pobj O157,of
R325 T391 T390 punct :,O157
R326 T392 T390 appos H7,O157
R327 T393 T377 punct .,promotes
R506 T263 T264 compound infection,NF-κB
R507 T264 T265 nsubj NF-κB,is
R508 T265 T265 ROOT is,is
R509 T266 T269 det a,regulator
R510 T267 T269 amod major,regulator
R511 T268 T269 compound gene,regulator
R512 T269 T265 attr regulator,is
R513 T270 T269 prep in,regulator
R514 T271 T272 amod immune,responses
R515 T272 T270 pobj responses,in
R516 T273 T272 cc and,responses
R517 T274 T276 amod ribosomal,S3
R518 T275 T276 compound protein,S3
R519 T276 T269 appos S3,regulator
R520 T277 T278 punct (,RPS3
R521 T278 T276 appos RPS3,S3
R522 T279 T276 punct ),S3
R523 T280 T265 conj is,is
R524 T281 T283 det an,subunit
R525 T282 T283 amod NF-κB,subunit
R526 T283 T280 attr subunit,is
R963 T1161 T1163 compound Nuclear,B
R964 T1162 T1163 compound Factor-kappa,B
R965 T1163 T1167 nsubj B,regulates
R966 T1164 T1163 punct (,B
R967 T1165 T1163 appos NF-κB,B
R968 T1166 T1163 punct ),B
R969 T1167 T1167 ROOT regulates,regulates
R970 T1168 T1170 amod crucial,functions
R971 T1169 T1170 amod cellular,functions
R972 T1170 T1167 dobj functions,regulates
R973 T1171 T1170 cc and,functions
R974 T1172 T1173 amod diverse,stimuli
R975 T1173 T1170 conj stimuli,functions
R976 T1174 T1167 conj activate,regulates
R977 T1175 T1178 det this,factor
R978 T1176 T1178 amod pleiotropic,factor
R979 T1177 T1178 compound transcription,factor
R980 T1178 T1174 dobj factor,activate
R981 T1179 T1178 punct ",",factor
R982 T1180 T1183 nsubj which,regulates
R983 T1181 T1183 prep in,regulates
R984 T1182 T1181 pobj turn,in
R985 T1183 T1178 relcl regulates,factor
R986 T1184 T1186 det a,array
R987 T1185 T1186 amod vast,array
R988 T1186 T1183 dobj array,regulates
R989 T1187 T1186 prep of,array
R990 T1188 T1189 amod genetic,targets1-3
R991 T1189 T1187 pobj targets1-3,of
R992 T1190 T1167 punct .,regulates
R993 T1191 T1195 det The,subunits
R994 T1192 T1195 amod best-known,subunits
R995 T1193 T1195 amod mammalian,subunits
R996 T1194 T1195 compound NF-κB,subunits
R997 T1195 T1196 nsubj subunits,are
R998 T1196 T1196 ROOT are,are
R999 T1197 T1198 compound Rel,proteins
R1000 T1198 T1196 attr proteins,are
R1001 T1199 T1198 punct ",",proteins
R1002 T1200 T1198 prep including,proteins
R1003 T1201 T1200 pobj RelA,including
R1004 T1202 T1203 punct (,p65
R1005 T1203 T1201 appos p65,RelA
R1006 T1204 T1201 punct ),RelA
R1007 T1205 T1201 punct ",",RelA
R1008 T1206 T1201 conj RelB,RelA
R1009 T1207 T1206 punct ",",RelB
R1010 T1208 T1206 conj c-Rel,RelB
R1011 T1209 T1208 punct ",",c-Rel
R1012 T1210 T1208 appos p50,c-Rel
R1013 T1211 T1208 punct ",",c-Rel
R1014 T1212 T1208 cc and,c-Rel
R1015 T1213 T1208 conj p52,c-Rel
R1016 T1214 T1215 punct (,refs
R1017 T1215 T1206 appos refs,RelB
R1018 T1216 T1217 punct .,"4, 5"
R1019 T1217 T1215 nummod "4, 5",refs
R1020 T1218 T1215 punct ),refs
R1021 T1219 T1196 punct .,are
R1022 T1220 T1224 advmod However,demonstrated
R1023 T1221 T1224 punct ",",demonstrated
R1024 T1222 T1224 nsubj we,demonstrated
R1025 T1223 T1224 advmod recently,demonstrated
R1026 T1224 T1224 ROOT demonstrated,demonstrated
R1027 T1225 T1232 mark that,is
R1028 T1226 T1232 nsubj ribosomal,is
R1029 T1227 T1232 nsubj protein,is
R1030 T1228 T1232 nsubj S3,is
R1031 T1229 T1230 punct (,RPS3
R1032 T1230 T1228 appos RPS3,S3
R1033 T1231 T1228 punct ),S3
R1034 T1232 T1224 ccomp is,demonstrated
R1035 T1233 T1236 det a,subunit
R1036 T1234 T1236 amod key,subunit
R1037 T1235 T1236 amod non-Rel,subunit
R1038 T1236 T1232 attr subunit,is
R1039 T1237 T1236 prep of,subunit
R1040 T1238 T1241 amod certain,complexes6
R1041 T1239 T1240 amod native,NF-κB
R1042 T1240 T1241 compound NF-κB,complexes6
R1043 T1241 T1237 pobj complexes6,of
R1044 T1242 T1224 punct .,demonstrated
R1045 T1243 T1245 nsubjpass RPS3,defined
R1046 T1244 T1245 auxpass is,defined
R1047 T1245 T1245 ROOT defined,defined
R1048 T1246 T1245 prep as,defined
R1049 T1247 T1249 det a,subunit
R1050 T1248 T1249 nmod specifier,subunit
R1051 T1249 T1246 pobj subunit,as
R1052 T1250 T1249 prep of,subunit
R1053 T1251 T1250 pobj NF-κB,of
R1054 T1252 T1245 punct ",",defined
R1055 T1253 T1255 mark because,facilitates
R1056 T1254 T1255 nsubj it,facilitates
R1057 T1255 T1245 advcl facilitates,defined
R1058 T1256 T1257 amod high,affinity
R1059 T1257 T1258 compound affinity,DNA
R1060 T1258 T1259 nsubj DNA,binding
R1061 T1259 T1255 ccomp binding,facilitates
R1062 T1260 T1261 advmod thus,determining
R1063 T1261 T1259 xcomp determining,binding
R1064 T1262 T1264 det the,specificity
R1065 T1263 T1264 amod regulatory,specificity
R1066 T1264 T1261 dobj specificity,determining
R1067 T1265 T1264 prep of,specificity
R1068 T1266 T1265 pobj NF-κB,of
R1069 T1267 T1264 prep for,specificity
R1070 T1268 T1269 amod selected,target
R1071 T1269 T1270 compound target,genes7
R1072 T1270 T1267 pobj genes7,for
R1073 T1271 T1245 punct .,defined
R1074 T1272 T1273 nummod RPS3,regulation
R1075 T1273 T1312 nsubj regulation,9
R1076 T1274 T1273 prep of,regulation
R1077 T1275 T1276 amod NF-κB,governs
R1078 T1276 T1274 pobj governs,of
R1079 T1277 T1279 amod key,processes
R1080 T1278 T1279 amod physiological,processes
R1081 T1279 T1276 dobj processes,governs
R1082 T1280 T1279 punct ",",processes
R1083 T1281 T1279 prep including,processes
R1084 T1282 T1287 nmod immunoglobulin,expression
R1085 T1283 T1287 nmod κ,expression
R1086 T1284 T1287 nmod light,expression
R1087 T1285 T1287 compound chain,expression
R1088 T1286 T1287 compound gene,expression
R1089 T1287 T1297 nmod expression,production
R1090 T1288 T1287 cc and,expression
R1091 T1289 T1290 compound receptor,editing
R1092 T1290 T1287 conj editing,expression
R1093 T1291 T1287 prep in,expression
R1094 T1292 T1291 pobj B,in
R1095 T1293 T1292 nummod cells6,B
R1096 T1294 T1292 appos ", 8",B
R1097 T1295 T1287 punct ",",expression
R1098 T1296 T1297 compound cytokine,production
R1099 T1297 T1281 pobj production,including
R1100 T1298 T1297 prep in,production
R1101 T1299 T1298 pobj T,in
R1102 T1300 T1299 appos cells6,T
R1103 T1301 T1297 punct ",",production
R1104 T1302 T1273 cc and,regulation
R1105 T1303 T1273 conj in,regulation
R1106 T1304 T1305 compound host,defense
R1107 T1305 T1303 pobj defense,in
R1108 T1306 T1305 prep against,defense
R1109 T1307 T1308 compound enterohemorrhagic Escherichia,coli
R1110 T1308 T1306 pobj coli,against
R1111 T1309 T1310 punct (,EHEC
R1112 T1310 T1308 appos EHEC,coli
R1113 T1311 T1312 punct ),9
R1114 T1312 T1312 ROOT 9,9
R1115 T1313 T1312 punct .,9
R1116 T1314 T1317 prep In,the E
R1117 T1315 T1314 amod particular,In
R1118 T1316 T1317 punct ",",the E
R1119 T1317 T1317 ROOT the E,the E
R1120 T1318 T1317 punct .,the E
R1121 T1319 T1319 ROOT coli O157,coli O157
R1122 T1320 T1319 punct :,coli O157
R1123 T1321 T1325 compound H7,system
R1124 T1322 T1325 compound type,system
R1125 T1323 T1325 compound III,system
R1126 T1324 T1325 compound secretion,system
R1127 T1325 T1325 ROOT system,system
R1128 T1326 T1325 punct (,system
R1129 T1327 T1325 appos T3SS,system
R1130 T1328 T1325 punct ),system
R1131 T1329 T1330 compound effector,protein
R1132 T1330 T1333 compound protein,blocks
R1133 T1331 T1333 nsubj NleH1,blocks
R1134 T1332 T1333 advmod selectively,blocks
R1135 T1333 T1333 ROOT blocks,blocks
R1136 T1334 T1337 compound NF-κB,transcription
R1137 T1335 T1336 compound target,gene
R1138 T1336 T1337 compound gene,transcription
R1139 T1337 T1333 dobj transcription,blocks
R1140 T1338 T1333 prep by,blocks
R1141 T1339 T1338 pcomp attenuating,by
R1142 T1340 T1342 amod RPS3,translocation
R1143 T1341 T1342 amod nuclear,translocation
R1144 T1342 T1339 dobj translocation,attenuating
R1145 T1343 T1333 punct ",",blocks
R1146 T1344 T1333 prep without,blocks
R1147 T1345 T1344 pcomp affecting,without
R1148 T1346 T1347 nummod p65,localization9
R1149 T1347 T1345 dobj localization9,affecting
R1150 T1348 T1333 punct .,blocks
R1151 T1349 T1356 advmod Nonetheless,induce
R1152 T1350 T1356 punct ",",induce
R1153 T1351 T1352 advmod how,specific
R1154 T1352 T1355 amod specific,signals
R1155 T1353 T1354 npadvmod NF-κB,activating
R1156 T1354 T1355 amod activating,signals
R1157 T1355 T1356 nsubj signals,induce
R1158 T1356 T1356 ROOT induce,induce
R1159 T1357 T1356 dobj RPS3,induce
R1160 T1358 T1359 amod nuclear,translocation
R1161 T1359 T1360 nsubj translocation,is
R1162 T1360 T1356 advcl is,induce
R1163 T1361 T1362 amod "unknown. Extra-ribosomal",functions
R1164 T1362 T1365 nsubjpass functions,ascribed
R1165 T1363 T1365 aux have,ascribed
R1166 T1364 T1365 auxpass been,ascribed
R1167 T1365 T1360 ccomp ascribed,is
R1168 T1366 T1365 prep to,ascribed
R1169 T1367 T1368 amod ribosomal,proteins10
R1170 T1368 T1366 pobj proteins10,to
R1171 T1369 T1360 punct .,is
R1172 T1370 T1380 prep Besides,participates
R1173 T1371 T1372 amod binding,RNA
R1174 T1372 T1370 pobj RNA,Besides
R1175 T1373 T1372 prep within,RNA
R1176 T1374 T1377 det the,subunit
R1177 T1375 T1377 nmod 40S,subunit
R1178 T1376 T1377 amod ribosomal,subunit
R1179 T1377 T1373 pobj subunit,within
R1180 T1378 T1380 punct ",",participates
R1181 T1379 T1380 nsubj RPS3,participates
R1182 T1380 T1380 ROOT participates,participates
R1183 T1381 T1380 prep in,participates
R1184 T1382 T1381 pobj transcription6,in
R1185 T1383 T1380 punct ",",participates
R1186 T1384 T1380 npadvmod DNA,participates
R1187 T1385 T1384 nummod repair11,DNA
R1188 T1386 T1384 appos ", 12",DNA
R1189 T1387 T1384 punct ",",DNA
R1190 T1388 T1384 cc and,DNA
R1191 T1389 T1384 conj apoptosis13,DNA
R1192 T1390 T1380 punct .,participates
R1193 T1391 T1395 mark Whether,is
R1194 T1392 T1395 cc or,is
R1195 T1393 T1395 neg not,is
R1196 T1394 T1395 nsubj RPS3,is
R1197 T1395 T1395 ROOT is,is
R1198 T1396 T1399 nsubjpass phosphorylated,controversial14-18
R1199 T1397 T1398 aux had,been
R1200 T1398 T1399 auxpass been,controversial14-18
R1201 T1399 T1395 attr controversial14-18,is
R1202 T1400 T1395 punct .,is
R1203 T1401 T1404 mark Since,play
R1204 T1402 T1403 compound kinase,cascades
R1205 T1403 T1404 nsubj cascades,play
R1206 T1404 T1413 advcl play,tested
R1207 T1405 T1407 det a,role
R1208 T1406 T1407 amod critical,role
R1209 T1407 T1404 dobj role,play
R1210 T1408 T1407 prep in,role
R1211 T1409 T1410 amod NF-κB,regulation
R1212 T1410 T1408 pobj regulation,in
R1213 T1411 T1413 punct ",",tested
R1214 T1412 T1413 nsubj we,tested
R1215 T1413 T1413 ROOT tested,tested
R1216 T1414 T1416 mark whether,is
R1217 T1415 T1416 nsubj RPS3,is
R1218 T1416 T1413 ccomp is,tested
R1219 T1417 T1416 acomp phosphorylated,is
R1220 T1418 T1417 prep in,phosphorylated
R1221 T1419 T1420 det the,context
R1222 T1420 T1418 pobj context,in
R1223 T1421 T1420 prep of,context
R1224 T1422 T1423 amod NF-κB,activation
R1225 T1423 T1421 pobj activation,of
R1226 T1424 T1417 cc and,phosphorylated
R1227 T1425 T1417 conj sought,phosphorylated
R1228 T1426 T1427 aux to,identify
R1229 T1427 T1425 xcomp identify,sought
R1230 T1428 T1430 det the,kinase19
R1231 T1429 T1430 amod responsible,kinase19
R1232 T1430 T1427 dobj kinase19,identify
R1233 T1431 T1413 punct .,tested
R1234 T1432 T1435 advmod Additionally,aimed
R1235 T1433 T1435 punct ",",aimed
R1236 T1434 T1435 nsubj we,aimed
R1237 T1435 T1435 ROOT aimed,aimed
R1238 T1436 T1437 aux to,define
R1239 T1437 T1435 xcomp define,aimed
R1240 T1438 T1440 det a,role
R1241 T1439 T1440 amod regulatory,role
R1242 T1440 T1437 dobj role,define
R1243 T1441 T1440 prep for,role
R1244 T1442 T1444 det the,tail
R1245 T1443 T1444 amod C-terminal,tail
R1246 T1444 T1441 pobj tail,for
R1247 T1445 T1444 prep of,tail
R1248 T1446 T1445 pobj RPS3,of
R1249 T1447 T1448 poss whose,function
R1250 T1448 T1449 nsubj function,was
R1251 T1449 T1435 conj was,aimed
R1252 T1450 T1449 acomp "unknown. Here",was
R1253 T1451 T1452 nsubj we,show
R1254 T1452 T1449 ccomp show,was
R1255 T1453 T1466 mark that,phosphorylated
R1256 T1454 T1455 det the,Inhibitor
R1257 T1455 T1462 nmod Inhibitor,beta
R1258 T1456 T1455 prep of,Inhibitor
R1259 T1457 T1456 pobj κB,of
R1260 T1458 T1457 punct (,κB
R1261 T1459 T1457 appos IκB,κB
R1262 T1460 T1457 punct ),κB
R1263 T1461 T1462 compound kinase,beta
R1264 T1462 T1466 nsubj beta,phosphorylated
R1265 T1463 T1462 punct (,beta
R1266 T1464 T1462 appos IKKβ,beta
R1267 T1465 T1462 punct ),beta
R1268 T1466 T1452 ccomp phosphorylated,show
R1269 T1467 T1466 dobj RPS3,phosphorylated
R1270 T1468 T1466 prep at,phosphorylated
R1271 T1469 T1468 pobj serine,at
R1272 T1470 T1469 nummod 209,serine
R1273 T1471 T1472 punct (,S209
R1274 T1472 T1469 appos S209,serine
R1275 T1473 T1466 punct ),phosphorylated
R1276 T1474 T1449 punct .,was
R1277 T1475 T1478 nsubj RPS3,enhanced
R1278 T1476 T1477 nummod S209,phosphorylation
R1279 T1477 T1478 nsubj phosphorylation,enhanced
R1280 T1478 T1478 ROOT enhanced,enhanced
R1281 T1479 T1480 poss its,association
R1282 T1480 T1478 dobj association,enhanced
R1283 T1481 T1480 prep with,association
R1284 T1482 T1481 pobj importin-α,with
R1285 T1483 T1478 punct ",",enhanced
R1286 T1484 T1478 advcl mediating,enhanced
R1287 T1485 T1486 nummod RPS3,entry
R1288 T1486 T1484 dobj entry,mediating
R1289 T1487 T1486 prep into,entry
R1290 T1488 T1490 det the,pathway
R1291 T1489 T1490 compound karyopherin,pathway
R1292 T1490 T1487 pobj pathway,into
R1293 T1491 T1484 prep for,mediating
R1294 T1492 T1493 amod nuclear,translocation
R1295 T1493 T1491 pobj translocation,for
R1296 T1494 T1478 punct .,enhanced
R1297 T1495 T1497 advmod Furthermore,the E
R1298 T1496 T1497 punct ",",the E
R1299 T1497 T1497 ROOT the E,the E
R1300 T1498 T1497 punct .,the E
R1301 T1499 T1500 nummod coli NleH1,effector
R1302 T1500 T1502 nsubj effector,inhibited
R1303 T1501 T1502 advmod specifically,inhibited
R1304 T1502 T1502 ROOT inhibited,inhibited
R1305 T1503 T1504 compound RPS3,S209
R1306 T1504 T1502 dobj S209,inhibited
R1307 T1505 T1502 advcl revealing,inhibited
R1308 T1506 T1505 dobj how E,revealing
R1309 T1507 T1502 punct .,inhibited
R1310 T1508 T1508 ROOT coli O157,coli O157
R1311 T1509 T1508 punct :,coli O157
R1312 T1510 T1511 nsubj H7,inhibits
R1313 T1511 T1511 ROOT inhibits,inhibits
R1314 T1512 T1517 det this,mechanism
R1315 T1513 T1517 amod important,mechanism
R1316 T1514 T1517 amod innate,mechanism
R1317 T1515 T1516 amod immune,response
R1318 T1516 T1517 compound response,mechanism
R1319 T1517 T1511 dobj mechanism,inhibits
R1320 T1518 T1511 punct .,inhibits
R1727 T2170 T2171 nummod RPS3,phosphorylation
R1728 T2171 T2178 nsubj phosphorylation,test
R1729 T2172 T2171 prep in,phosphorylation
R1730 T2173 T2172 pobj response,in
R1731 T2174 T2173 prep to,response
R1732 T2175 T2176 amod NF-κB,activation
R1733 T2176 T2174 pobj activation,to
R1734 T2177 T2178 aux To,test
R1735 T2178 T2188 npadvmod test,performed
R1736 T2179 T2181 mark whether,is
R1737 T2180 T2181 nsubj RPS3,is
R1738 T2181 T2188 advcl is,performed
R1739 T2182 T2181 acomp phosphorylated,is
R1740 T2183 T2182 prep during,phosphorylated
R1741 T2184 T2185 compound NF-κB,activation
R1742 T2185 T2183 pobj activation,during
R1743 T2186 T2188 punct ",",performed
R1744 T2187 T2188 nsubj we,performed
R1745 T2188 T2199 ccomp performed,stimulated
R1746 T2189 T2190 amod 32P-labeling,experiments
R1747 T2190 T2188 dobj experiments,performed
R1748 T2191 T2188 prep in,performed
R1749 T2192 T2193 compound tumor,necrosis
R1750 T2193 T2194 compound necrosis,factor
R1751 T2194 T2191 pobj factor,in
R1752 T2195 T2196 punct (,TNF
R1753 T2196 T2194 appos TNF,factor
R1754 T2197 T2188 punct ),performed
R1755 T2198 T2199 punct -,stimulated
R1756 T2199 T2199 ROOT stimulated,stimulated
R1757 T2200 T2201 compound HEK,293T
R1758 T2201 T2202 nummod 293T,cells
R1759 T2202 T2199 dobj cells,stimulated
R1760 T2203 T2199 punct .,stimulated
R1761 T2204 T2208 mark While,phosphorylated
R1762 T2205 T2208 nsubjpass RPS3,phosphorylated
R1763 T2206 T2208 auxpass was,phosphorylated
R1764 T2207 T2208 advmod scarcely,phosphorylated
R1765 T2208 T2214 advcl phosphorylated,observed
R1766 T2209 T2208 prep in,phosphorylated
R1767 T2210 T2211 amod unstimulated,cells
R1768 T2211 T2209 pobj cells,in
R1769 T2212 T2214 punct ",",observed
R1770 T2213 T2214 nsubj we,observed
R1771 T2214 T2214 ROOT observed,observed
R1772 T2215 T2217 det a,increase
R1773 T2216 T2217 amod marked,increase
R1774 T2217 T2214 dobj increase,observed
R1775 T2218 T2217 prep in,increase
R1776 T2219 T2218 pobj 32P-incorporation,in
R1777 T2220 T2217 prep after,increase
R1778 T2221 T2222 compound TNF,stimulation
R1779 T2222 T2220 pobj stimulation,after
R1780 T2223 T2214 prep despite,observed
R1781 T2224 T2225 det no,increase
R1782 T2225 T2223 pobj increase,despite
R1783 T2226 T2225 prep in,increase
R1784 T2227 T2228 nummod RPS3,protein
R1785 T2228 T2226 pobj protein,in
R1786 T2229 T2230 punct (,Fig.
R1787 T2230 T2225 appos Fig.,increase
R1788 T2231 T2230 nummod 1a,Fig.
R1789 T2232 T2214 punct ),observed
R1790 T2233 T2214 punct .,observed
R1791 T2234 T2235 aux To,determine
R1792 T2235 T2243 advcl determine,immunoprecipitated
R1793 T2236 T2238 det which,residues
R1794 T2237 T2238 compound RPS3,residues
R1795 T2238 T2239 nsubj residues,were
R1796 T2239 T2235 ccomp were,determine
R1797 T2240 T2239 attr phosphorylated,were
R1798 T2241 T2243 punct ",",immunoprecipitated
R1799 T2242 T2243 nsubj we,immunoprecipitated
R1800 T2243 T2243 ROOT immunoprecipitated,immunoprecipitated
R1801 T2244 T2243 dobj RPS3,immunoprecipitated
R1802 T2245 T2243 prep from,immunoprecipitated
R1803 T2246 T2247 preconj either,resting
R1804 T2247 T2245 pobj resting,from
R1805 T2248 T2247 cc or,resting
R1806 T2249 T2250 amod stimulated,cells
R1807 T2250 T2247 conj cells,resting
R1808 T2251 T2243 cc and,immunoprecipitated
R1809 T2252 T2243 conj performed,immunoprecipitated
R1810 T2253 T2252 xcomp immunoblotting,performed
R1811 T2254 T2253 prep with,immunoblotting
R1812 T2255 T2256 amod phosphorylation-specific,antibodies
R1813 T2256 T2254 pobj antibodies,with
R1814 T2257 T2243 punct .,immunoprecipitated
R1815 T2258 T2259 det Both,TNF
R1816 T2259 T2263 nmod TNF,acetate/ionomycin
R1817 T2260 T2259 cc and,TNF
R1818 T2261 T2259 conj phorbol,TNF
R1819 T2262 T2263 compound myristate,acetate/ionomycin
R1820 T2263 T2267 nsubj acetate/ionomycin,stimulated
R1821 T2264 T2265 punct (,PMA+I
R1822 T2265 T2263 appos PMA+I,acetate/ionomycin
R1823 T2266 T2263 punct ),acetate/ionomycin
R1824 T2267 T2267 ROOT stimulated,stimulated
R1825 T2268 T2269 amod rapid,phosphorylation
R1826 T2269 T2267 dobj phosphorylation,stimulated
R1827 T2270 T2269 cc and,phosphorylation
R1828 T2271 T2269 conj degradaion,phosphorylation
R1829 T2272 T2269 prep of,phosphorylation
R1830 T2273 T2272 pobj IκBα,of
R1831 T2274 T2267 prep within,stimulated
R1832 T2275 T2276 nummod 5,min
R1833 T2276 T2274 pobj min,within
R1834 T2277 T2279 nsubjpass which,accompanied
R1835 T2278 T2279 auxpass was,accompanied
R1836 T2279 T2276 relcl accompanied,min
R1837 T2280 T2279 agent by,accompanied
R1838 T2281 T2282 nummod RPS3,phosphorylation
R1839 T2282 T2280 pobj phosphorylation,by
R1840 T2283 T2282 prep on,phosphorylation
R1841 T2284 T2285 compound serine,residues
R1842 T2285 T2283 pobj residues,on
R1843 T2286 T2282 punct (,phosphorylation
R1844 T2287 T2282 appos Fig.,phosphorylation
R1845 T2288 T2287 nummod 1b,Fig.
R1846 T2289 T2282 cc and,phosphorylation
R1847 T2290 T2282 conj data,phosphorylation
R1848 T2291 T2292 neg not,shown
R1849 T2292 T2279 conj shown,accompanied
R1850 T2293 T2292 punct ),shown
R1851 T2294 T2292 punct ",",shown
R1852 T2295 T2292 conj similar,shown
R1853 T2296 T2295 prep to,similar
R1854 T2297 T2296 pobj the,to
R1855 T2298 T2297 prep in,the
R1856 T2299 T2300 compound vivo,labeling
R1857 T2300 T2267 advcl labeling,stimulated
R1858 T2301 T2267 punct .,stimulated
R1859 T2302 T2305 nsubj We,detect
R1860 T2303 T2305 aux did,detect
R1861 T2304 T2305 neg not,detect
R1862 T2305 T2305 ROOT detect,detect
R1863 T2306 T2305 dobj tyrosine,detect
R1864 T2307 T2306 punct -,tyrosine
R1865 T2308 T2306 cc or,tyrosine
R1866 T2309 T2306 conj threonine-phosphorylation,tyrosine
R1867 T2310 T2306 prep of,tyrosine
R1868 T2311 T2310 pobj RPS3,of
R1869 T2312 T2313 punct (,Fig.
R1870 T2313 T2311 appos Fig.,RPS3
R1871 T2314 T2313 nummod 1b,Fig.
R1872 T2315 T2311 punct ),RPS3
R1873 T2316 T2305 punct .,detect
R2231 T2826 T2829 nummod RPS3,interaction
R2232 T2827 T2826 cc and,RPS3
R2233 T2828 T2829 compound IKKβ,interaction
R2234 T2829 T2857 nsubj interaction,is
R2235 T2830 T2831 det The,activation
R2236 T2831 T2842 nsubj activation,consisting
R2237 T2832 T2831 prep of,activation
R2238 T2833 T2834 det the,inhibitor
R2239 T2834 T2832 pobj inhibitor,of
R2240 T2835 T2834 prep of,inhibitor
R2241 T2836 T2837 compound κB,kinase
R2242 T2837 T2835 pobj kinase,of
R2243 T2838 T2839 punct (,IKK
R2244 T2839 T2837 appos IKK,kinase
R2245 T2840 T2839 punct ),IKK
R2246 T2841 T2831 punct ",",activation
R2247 T2842 T2829 acl consisting,interaction
R2248 T2843 T2842 prep of,consisting
R2249 T2844 T2846 det a,subunit
R2250 T2845 T2846 amod regulatory,subunit
R2251 T2846 T2843 pobj subunit,of
R2252 T2847 T2846 appos IKKγ,subunit
R2253 T2848 T2842 cc and,consisting
R2254 T2849 T2851 nummod two,subunits
R2255 T2850 T2851 amod catalytic,subunits
R2256 T2851 T2842 conj subunits,consisting
R2257 T2852 T2851 punct ",",subunits
R2258 T2853 T2851 appos IKKα,subunits
R2259 T2854 T2853 cc and,IKKα
R2260 T2855 T2853 conj IKKβ,IKKα
R2261 T2856 T2857 punct ",",is
R2262 T2857 T2857 ROOT is,is
R2263 T2858 T2857 acomp critical,is
R2264 T2859 T2858 prep for,critical
R2265 T2860 T2861 det the,phosphorylation
R2266 T2861 T2859 pobj phosphorylation,for
R2267 T2862 T2861 cc and,phosphorylation
R2268 T2863 T2861 conj dispatch,phosphorylation
R2269 T2864 T2861 prep of,phosphorylation
R2270 T2865 T2867 det the,IκBs
R2271 T2866 T2867 amod inhibitory,IκBs
R2272 T2867 T2864 pobj IκBs,of
R2273 T2868 T2867 cc and,IκBs
R2348 T2943 T2939 pobj transcription,for
R2349 T2944 T2943 acl required,transcription
R2350 T2945 T2944 prep for,required
R2351 T2946 T2947 compound cell,proliferation
R2352 T2947 T2945 pobj proliferation,for
R2353 T2948 T2947 cc and,proliferation
R2354 T2949 T2947 conj survival,proliferation
R2355 T2950 T2921 punct .,examined
R2356 T2951 T2952 amod RPS3-IKKβ,association
R2357 T2952 T2955 nsubjpass association,augmented
R2358 T2953 T2955 auxpass was,augmented
R2359 T2954 T2955 advmod clearly,augmented
R2360 T2955 T2955 ROOT augmented,augmented
R2361 T2956 T2955 prep upon,augmented
R2362 T2957 T2958 compound TNF,stimulation
R2363 T2958 T2956 pobj stimulation,upon
R2364 T2959 T2955 punct ",",augmented
R2365 T2960 T2955 advcl peaking,augmented
R2366 T2961 T2960 prep at,peaking
R2367 T2962 T2963 nummod 10,min
R2368 T2963 T2961 pobj min,at
R2369 T2964 T2955 punct .,augmented
R2370 T2965 T2970 punct (,following
R2371 T2966 T2966 ROOT Fig.,Fig.
R2372 T2967 T2966 nummod 1d,Fig.
R2373 T2968 T2966 punct ),Fig.
R2374 T2969 T2970 punct ",",following
R2375 T2970 T2970 ROOT following,following
R2376 T2971 T2972 amod similar,kinetics
R2377 T2972 T2970 dobj kinetics,following
R2378 T2973 T2970 prep to,following
R2379 T2974 T2976 nummod RPS3,phosphorylation
R2380 T2975 T2976 compound serine,phosphorylation
R2381 T2976 T2973 pobj phosphorylation,to
R2382 T2977 T2976 punct (,phosphorylation
R2383 T2978 T2976 appos Fig.,phosphorylation
R2384 T2979 T2978 nummod 1b,Fig.
R2385 T2980 T2976 punct ),phosphorylation
R2386 T2981 T2970 punct .,following
R2387 T2982 T2986 prep By,was
R2388 T2983 T2982 pobj contrast,By
R2389 T2984 T2986 punct ",",was
R2390 T2985 T2986 expl there,was
R2391 T2986 T2986 ROOT was,was
R2392 T2987 T2989 det no,interaction
R2393 T2988 T2989 amod detectable,interaction
R2394 T2989 T2986 attr interaction,was
R2395 T2990 T2989 prep between,interaction
R2396 T2991 T2990 pobj RPS3,between
R2397 T2992 T2991 cc and,RPS3
R2398 T2993 T2991 conj IKKα,RPS3
R2399 T2994 T2995 punct (,Fig.
R2400 T2995 T2993 appos Fig.,IKKα
R2401 T2996 T2995 nummod 1d,Fig.
R2402 T2997 T2993 punct ),IKKα
R2403 T2998 T2986 punct .,was
R3096 T3905 T3908 nsubj TNF,triggered
R3097 T3906 T3905 cc and,TNF
R3098 T3907 T3905 conj PMA+I,TNF
R3099 T3908 T3908 ROOT triggered,triggered
R3100 T3909 T3911 nummod RPS3,translocation
R3101 T3910 T3911 amod nuclear,translocation
R3102 T3911 T3908 dobj translocation,triggered
R3103 T3912 T3911 prep in,translocation
R3104 T3913 T3914 compound Jurkat,cells
R3105 T3914 T3912 pobj cells,in
R3106 T3915 T3908 conj transfected,triggered
R3107 T3916 T3915 prep with,transfected
R3108 T3917 T3919 det a,nonspecific
R3109 T3918 T3919 amod scrambled,nonspecific
R3110 T3919 T3916 pobj nonspecific,with
R3111 T3920 T3923 punct (,siRNA
R3112 T3921 T3923 nmod NS,siRNA
R3113 T3922 T3923 punct ),siRNA
R3114 T3923 T3919 appos siRNA,nonspecific
R3115 T3924 T3923 punct (,siRNA
R3116 T3925 T3923 appos Fig.,siRNA
R3117 T3926 T3925 nummod 2a,Fig.
R3118 T3927 T3925 punct ),Fig.
R3119 T3928 T3923 npadvmod 6,siRNA
R3120 T3929 T3923 punct .,siRNA
R3121 T3930 T3932 nummod RPS3,translocation
R3122 T3931 T3932 amod nuclear,translocation
R3123 T3932 T3933 nsubj translocation,was
R3124 T3933 T3933 ROOT was,was
R3125 T3934 T3935 advmod only,slightly
R3126 T3935 T3933 advmod slightly,was
R3127 T3936 T3933 punct ",",was
R3128 T3937 T3941 mark if,impaired
R3129 T3938 T3939 advmod at,all
R3130 T3939 T3941 dep all,impaired
R3131 T3940 T3941 punct ",",impaired
R2274 T2869 T2870 det the,liberation
R2275 T2870 T2867 conj liberation,IκBs
R2276 T2871 T2870 prep of,liberation
R2277 T2872 T2871 pobj NF-κB20-22,of
R2278 T2873 T2857 punct .,is
R2279 T2874 T2891 prep Given,hypothesized
R2280 T2875 T2879 mark that,found
R2281 T2876 T2879 nsubjpass RPS3,found
R2282 T2877 T2879 aux can,found
R2283 T2878 T2879 auxpass be,found
R2284 T2879 T2874 pcomp found,Given
R2285 T2880 T2879 prep in,found
R2286 T2881 T2885 det the,complex
R2287 T2882 T2885 amod cytoplasmic,complex
R2288 T2883 T2885 compound p65-p50-IκBα,complex
R2289 T2884 T2885 compound inhibitory,complex
R2290 T2885 T2880 pobj complex,in
R2291 T2886 T2885 prep in,complex
R2292 T2887 T2886 pcomp resting,in
R2293 T2888 T2887 dobj cells6,resting
R2294 T2889 T2891 punct ",",hypothesized
R2295 T2890 T2891 nsubj we,hypothesized
R2296 T2891 T2891 ROOT hypothesized,hypothesized
R2297 T2892 T2897 mark that,bind
R2298 T2893 T2894 amod activated,IKKβ
R2299 T2894 T2897 nsubj IKKβ,bind
R2300 T2895 T2897 aux might,bind
R2301 T2896 T2897 advmod also,bind
R2302 T2897 T2891 ccomp bind,hypothesized
R2303 T2898 T2897 prep to,bind
R2304 T2899 T2897 cc and,bind
R2305 T2900 T2901 compound phosphorylate,RPS3
R2306 T2901 T2897 conj RPS3,bind
R2307 T2902 T2891 punct .,hypothesized
R2308 T2903 T2906 advmod First,found
R2309 T2904 T2906 punct ",",found
R2310 T2905 T2906 nsubj we,found
R2311 T2906 T2906 ROOT found,found
R2312 T2907 T2909 mark that,expressed
R2313 T2908 T2909 nsubj ectopically,expressed
R2314 T2909 T2906 ccomp expressed,found
R2315 T2910 T2913 nsubj IKKβ,interacted
R2316 T2911 T2910 cc and,IKKβ
R2317 T2912 T2910 conj RPS3,IKKβ
R2318 T2913 T2906 conj interacted,found
R2319 T2914 T2913 punct (,interacted
R2320 T2915 T2913 dobj Fig.,interacted
R2321 T2916 T2915 nummod 1c,Fig.
R2322 T2917 T2915 punct ),Fig.
R2323 T2918 T2913 punct .,interacted
R2324 T2919 T2921 nsubj We,examined
R2325 T2920 T2921 advmod next,examined
R2326 T2921 T2921 ROOT examined,examined
R2327 T2922 T2921 xcomp resting,examined
R2328 T2923 T2924 compound Jurkat,cells
R2329 T2924 T2922 dobj cells,resting
R2330 T2925 T2921 cc and,examined
R2331 T2926 T2921 conj detected,examined
R2332 T2927 T2931 det a,interaction
R2333 T2928 T2931 amod modest,interaction
R2334 T2929 T2931 amod endogenous,interaction
R2335 T2930 T2931 amod IKKβ-RPS3,interaction
R2336 T2931 T2926 dobj interaction,detected
R2337 T2932 T2931 punct (,interaction
R2338 T2933 T2931 appos Fig.,interaction
R2339 T2934 T2933 nummod 1d,Fig.
R2340 T2935 T2933 punct ),Fig.
R2341 T2936 T2931 punct ",",interaction
R2342 T2937 T2938 advmod potentially,accounting
R2343 T2938 T2926 advcl accounting,detected
R2344 T2939 T2938 prep for,accounting
R2345 T2940 T2943 det the,transcription
R2346 T2941 T2943 amod basal,transcription
R2347 T2942 T2943 compound NF-κB,transcription
R3050 T3859 T3861 nsubjpass IKKβ,required
R3051 T3860 T3861 auxpass is,required
R3052 T3861 T3880 ccomp required,knocked
R3053 T3862 T3861 prep for,required
R3054 T3863 T3865 nmod RPS3,translocation
R3055 T3864 T3865 amod nuclear,translocation
R3056 T3865 T3867 nsubj translocation,examine
R3057 T3866 T3867 aux To,examine
R3058 T3867 T3861 advcl examine,required
R3059 T3868 T3873 mark whether,required
R3060 T3869 T3871 det the,interaction
R3061 T3870 T3871 compound RPS3-IKKβ,interaction
R3062 T3871 T3873 nsubjpass interaction,required
R3063 T3872 T3873 auxpass is,required
R3064 T3873 T3867 ccomp required,examine
R3065 T3874 T3873 prep for,required
R3066 T3875 T3877 nmod RPS3,translocation
R3067 T3876 T3877 amod nuclear,translocation
R3068 T3877 T3874 pobj translocation,for
R3069 T3878 T3880 punct ",",knocked
R3070 T3879 T3880 nsubj we,knocked
R3071 T3880 T3880 ROOT knocked,knocked
R3072 T3881 T3880 prt down,knocked
R3073 T3882 T3885 poss IKKα,expression
R3074 T3883 T3882 cc or,IKKα
R3075 T3884 T3882 conj IKKβ,IKKα
R3076 T3885 T3880 dobj expression,knocked
R3077 T3886 T3880 prep with,knocked
R3078 T3887 T3886 pobj siRNAs,with
R3079 T3888 T3890 punct (,Fig.
R3080 T3889 T3890 compound Supplementary,Fig.
R3081 T3890 T3880 parataxis Fig.,knocked
R3082 T3891 T3890 nummod 1,Fig.
R3083 T3892 T3890 punct ),Fig.
R3084 T3893 T3880 cc and,knocked
R3085 T3894 T3895 advmod then,observed
R3086 T3895 T3880 conj observed,knocked
R3087 T3896 T3899 amod stimulation-induced,migration
R3088 T3897 T3899 nmod RPS3,migration
R3089 T3898 T3899 amod nuclear,migration
R3090 T3899 T3895 dobj migration,observed
R3091 T3900 T3899 prep by,migration
R3092 T3901 T3902 amod confocal,microscopy
R3093 T3902 T3900 pobj microscopy,by
R3094 T3903 T3880 punct .,knocked
R3095 T3904 T3905 det Both,TNF
R3171 T3980 T3979 acomp necessary,was
R3172 T3981 T3980 prep for,necessary
R3173 T3982 T3985 amod activation-induced,translocation
R3174 T3983 T3985 amod RPS3,translocation
R3175 T3984 T3985 amod nuclear,translocation
R3176 T3985 T3981 pobj translocation,for
R3177 T3986 T3985 punct (,translocation
R3178 T3987 T3985 appos Fig.,translocation
R3179 T3988 T3987 nummod 2b,Fig.
R3180 T3989 T3985 punct ),translocation
R3181 T3990 T3979 punct .,was
R3182 T3991 T3992 compound Control,immunoblots
R3183 T3992 T3993 nsubj immunoblots,revealed
R3184 T3993 T3993 ROOT revealed,revealed
R3185 T3994 T3999 mark that,blocked
R3186 T3995 T3997 nummod p65,translocation
R3187 T3996 T3997 amod nuclear,translocation
R3188 T3997 T3999 nsubjpass translocation,blocked
R3189 T3998 T3999 auxpass was,blocked
R3190 T3999 T3993 ccomp blocked,revealed
R3191 T4000 T3999 prep under,blocked
R3192 T4001 T4003 det the,conditions
R3193 T4002 T4003 amod same,conditions
R3194 T4003 T4000 pobj conditions,under
R3195 T4004 T3999 punct (,blocked
R3196 T4005 T4007 nmod Fig.,)
R3197 T4006 T4005 nummod 2b,Fig.
R3198 T4007 T3999 punct ),blocked
R3199 T4008 T3993 punct .,revealed
R3200 T4009 T4011 nsubj We,examined
R3201 T4010 T4011 advmod next,examined
R3202 T4011 T4011 ROOT examined,examined
R3203 T4012 T4014 det the,translocation
R3204 T4013 T4014 amod nuclear,translocation
R3205 T4014 T4011 dobj translocation,examined
R3206 T4015 T4014 prep of,translocation
R3207 T4016 T4015 pobj RPS3,of
R3208 T4017 T4014 prep in,translocation
R3132 T3941 T3933 advcl impaired,was
R3133 T3942 T3941 agent by,impaired
R3134 T3943 T3942 pobj IKKα-silencing,by
R3135 T3944 T3941 punct .,impaired
R3136 T3945 T3950 advmod Conversely,attenuated
R3137 T3946 T3950 punct ",",attenuated
R3138 T3947 T3950 nsubj knockdown,attenuated
R3139 T3948 T3947 prep of,knockdown
R3140 T3949 T3948 pobj IKKβ,of
R3141 T3950 T3950 ROOT attenuated,attenuated
R3142 T3951 T3952 nummod 60-70,%
R3143 T3952 T3950 dobj %,attenuated
R3144 T3953 T3952 prep of,%
R3145 T3954 T3956 nummod RPS3,accumulation
R3146 T3955 T3956 amod nuclear,accumulation
R3147 T3956 T3953 pobj accumulation,of
R3148 T3957 T3950 prep following,attenuated
R3149 T3958 T3957 pobj stimulation,following
R3150 T3959 T3957 punct (,following
R3151 T3960 T3962 nmod Fig.,)
R3152 T3961 T3960 nummod 2a,Fig.
R3153 T3962 T3950 punct ),attenuated
R3154 T3963 T3950 punct .,attenuated
R3155 T3964 T3968 nsubj Immunoblotting,confirmed
R3156 T3965 T3964 prep of,Immunoblotting
R3157 T3966 T3967 amod nuclear,fractions
R3158 T3967 T3965 pobj fractions,of
R3159 T3968 T3968 ROOT confirmed,confirmed
R3160 T3969 T3971 det that,expression
R3161 T3970 T3971 amod full,expression
R3162 T3971 T3968 dobj expression,confirmed
R3163 T3972 T3971 prep of,expression
R3164 T3973 T3972 pobj IKKβ,of
R3165 T3974 T3971 punct ",",expression
R3166 T3975 T3971 cc but,expression
R3167 T3976 T3977 neg not,IKKα
R3168 T3977 T3971 conj IKKα,expression
R3169 T3978 T3979 punct ",",was
R3170 T3979 T3971 conj was,expression
R3321 T4130 T4129 dobj ones,expressing
R3322 T4131 T4129 punct (,expressing
R3323 T4132 T4133 compound Fig.,2d
R3324 T4133 T4129 npadvmod 2d,expressing
R3325 T4134 T4129 cc and,expressing
R3326 T4135 T4136 compound Supplementary,Fig.
R3327 T4136 T4129 conj Fig.,expressing
R3328 T4137 T4136 nummod 2,Fig.
R3329 T4138 T4136 punct ),Fig.
R3330 T4139 T4110 punct .,increased
R3331 T4140 T4144 advmod Thus,is
R3332 T4141 T4144 punct ",",is
R3333 T4142 T4143 amod IKKβ,activity
R3343 T4152 T4144 prep in,is
R3344 T4153 T4152 pobj response,in
R3345 T4154 T4153 prep to,response
R3346 T4155 T4156 nsubj NF-κB,activating
R3347 T4156 T4154 pcomp activating,to
R3348 T4157 T4156 dobj stimuli,activating
R3349 T4158 T4144 punct .,is
R4530 T5651 T5650 pobj parallel,in
R4531 T5652 T5651 prep to,parallel
R4532 T5653 T5649 punct ",",occurs
R4533 T5654 T5649 cc but,occurs
R4534 T5655 T5656 advmod independently,of
R4535 T5656 T5649 conj of,occurs
R4536 T5657 T5656 punct ",",of
R4537 T5658 T5659 nummod p65,translocation6
R4538 T5659 T5656 pobj translocation6,of
R4539 T5660 T5649 punct .,occurs
R4540 T5661 T5662 nsubj We,envisioned
R4541 T5662 T5662 ROOT envisioned,envisioned
R4542 T5663 T5667 mark that,utilize
R4543 T5664 T5667 nsubj RPS3,utilize
R4544 T5665 T5667 aux could,utilize
R4545 T5666 T5667 advmod also,utilize
R4546 T5667 T5662 ccomp utilize,envisioned
R4547 T5668 T5672 det the,pathway
R4548 T5669 T5672 amod importin-α,pathway
R4549 T5670 T5672 nmod /,pathway
R4550 T5671 T5672 compound β,pathway
R4551 T5672 T5667 dobj pathway,utilize
R4552 T5673 T5662 punct .,envisioned
R4553 T5674 T5689 advmod Consistent,enhanced
R4554 T5675 T5674 prep with,Consistent
R3209 T4018 T4017 pobj cells,in
R3210 T4019 T4020 advmod ectopically,expressing
R3211 T4020 T4011 advcl expressing,examined
R3212 T4021 T4022 preconj either,kinase-dead
R3213 T4022 T4020 dobj kinase-dead,expressing
R3214 T4023 T4022 punct (,kinase-dead
R3215 T4024 T4022 appos SSAA,kinase-dead
R3216 T4025 T4024 punct ),SSAA
R3217 T4026 T4022 cc or,kinase-dead
R3218 T4027 T4022 conj constitutively-active,kinase-dead
R3219 T4028 T4027 punct (,constitutively-active
R3220 T4029 T4027 appos SSEE,constitutively-active
R3221 T4030 T4027 punct ),constitutively-active
R3222 T4031 T4033 amod mutant,proteins
R3223 T4032 T4033 compound IKKβ,proteins
R3224 T4033 T4022 conj proteins,kinase-dead
R3225 T4034 T4011 punct .,examined
R3226 T4035 T4036 mark As,expected
R3227 T4036 T4048 advcl expected,induced
R3228 T4037 T4048 punct ",",induced
R3229 T4038 T4039 det the,SSEE
R3230 T4039 T4048 nsubj SSEE,induced
R3231 T4040 T4039 punct ",",SSEE
R3232 T4041 T4039 cc but,SSEE
R3233 T4042 T4041 neg not,but
R3234 T4043 T4048 nsubj SSAA,induced
R3235 T4044 T4043 punct ",",SSAA
R3236 T4045 T4048 nsubj mutant,induced
R3237 T4046 T4045 prep of,mutant
R3238 T4047 T4046 pobj IKKβ,of
R3239 T4048 T4048 ROOT induced,induced
R3240 T4049 T4052 amod NF-κB-dependent,activity
R3241 T4050 T4052 compound luciferase,activity
R3242 T4051 T4052 compound reporter,activity
R3243 T4052 T4048 dobj activity,induced
R3244 T4053 T4054 punct (,Fig.
R3245 T4054 T4052 appos Fig.,activity
R3246 T4055 T4054 nummod 2c,Fig.
R3247 T4056 T4057 punct ",",left
R3248 T4057 T4048 conj left,induced
R3249 T4058 T4057 punct ),left
R3250 T4059 T4048 punct .,induced
R3251 T4060 T4062 mark Whereas,remained
R3252 T4061 T4062 nsubj RPS3,remained
R3253 T4062 T4062 ROOT remained,remained
R3254 T4063 T4062 acomp cytosolic,remained
R3255 T4064 T4062 prep in,remained
R3256 T4065 T4064 pobj IKKβ,in
R3257 T4066 T4065 punct (,IKKβ
R3258 T4067 T4065 appos SSAA,IKKβ
R3259 T4068 T4065 punct ),IKKβ
R3260 T4069 T4070 punct -,expressing
R3261 T4070 T4062 advcl expressing,remained
R3262 T4071 T4070 dobj cells,expressing
R3263 T4072 T4070 punct (,expressing
R3264 T4073 T4074 compound Fig.,2c
R3265 T4074 T4070 npadvmod 2c,expressing
R3266 T4075 T4076 punct ",",right
R3267 T4076 T4070 conj right,expressing
R3268 T4077 T4076 punct ),right
R3269 T4078 T4076 punct ",",right
R3270 T4079 T4081 det a,proportion
R3271 T4080 T4081 amod substantial,proportion
R3272 T4081 T4076 appos proportion,right
R3273 T4082 T4081 prep of,proportion
R3274 T4083 T4084 nummod RPS3,translocated
R3275 T4084 T4082 pobj translocated,of
R3276 T4085 T4084 prep to,translocated
R3277 T4086 T4087 det the,nucleus
R3278 T4087 T4085 pobj nucleus,to
R3279 T4088 T4087 prep in,nucleus
R3280 T4089 T4088 pobj cells,in
R3281 T4090 T4089 acl expressing,cells
R3282 T4091 T4090 dobj IKKβ,expressing
R3283 T4092 T4091 punct (,IKKβ
R3284 T4093 T4091 appos SSEE,IKKβ
R3285 T4094 T4091 punct ),IKKβ
R3286 T4095 T4096 punct (,Fig.
R3287 T4096 T4091 nmod Fig.,IKKβ
R3288 T4097 T4090 npadvmod 2c,expressing
R3289 T4098 T4099 punct ",",right
R3290 T4099 T4081 conj right,proportion
R3291 T4100 T4099 punct ),right
R3292 T4101 T4062 punct .,remained
R3293 T4102 T4103 det The,percentage
R3294 T4103 T4110 nsubj percentage,increased
R3295 T4104 T4103 prep of,percentage
R3296 T4105 T4104 pobj cells,of
R3297 T4106 T4105 acl containing,cells
R3298 T4107 T4109 amod detectable,RPS3
R3299 T4108 T4109 amod nuclear,RPS3
R3300 T4109 T4106 dobj RPS3,containing
R3301 T4110 T4110 ROOT increased,increased
R3302 T4111 T4110 dobj 5-fold,increased
R3303 T4112 T4110 prep in,increased
R3304 T4113 T4112 pobj IKKβ,in
R3305 T4114 T4113 punct (,IKKβ
R3306 T4115 T4113 appos SSEE,IKKβ
R3307 T4116 T4113 punct ),IKKβ
R3308 T4117 T4110 punct -,increased
R3309 T4118 T4110 advcl expressing,increased
R3310 T4119 T4118 dobj cells,expressing
R3311 T4120 T4110 punct ",",increased
R3312 T4121 T4110 cc but,increased
R3313 T4122 T4123 neg not,in
R3314 T4123 T4129 prep in,expressing
R3315 T4124 T4123 pobj IKKβ,in
R3316 T4125 T4124 punct (,IKKβ
R3317 T4126 T4124 appos SSAA,IKKβ
R3318 T4127 T4124 punct ),IKKβ
R3319 T4128 T4129 punct -,expressing
R3320 T4129 T4110 conj expressing,increased
R4496 T5617 T5618 compound IκBα,degradation
R4497 T5618 T5624 nsubj degradation,regulates
R4498 T5619 T5618 cc and,degradation
R4499 T5620 T5622 amod RPS3,translocation
R4500 T5621 T5622 amod nuclear,translocation
R4501 T5622 T5623 compound translocation,Importin-α
R4502 T5623 T5624 nsubj Importin-α,regulates
R4503 T5624 T5624 ROOT regulates,regulates
R4504 T5625 T5627 det the,import
R4505 T5626 T5627 amod nuclear,import
R4506 T5627 T5624 dobj import,regulates
R4507 T5628 T5627 prep of,import
R4508 T5629 T5630 compound NF-κB,Rel
R4509 T5630 T5628 pobj Rel,of
R4510 T5631 T5630 appos subunits23,Rel
R4511 T5632 T5630 punct ",",Rel
R4512 T5633 T5630 appos 24,Rel
R4513 T5634 T5624 punct .,regulates
R4514 T5635 T5636 nummod RPS3,harbors
R4515 T5636 T5649 dep harbors,occurs
R4516 T5637 T5640 det a,signal
R4517 T5638 T5639 amod nuclear,localization
R4518 T5639 T5640 compound localization,signal
R4519 T5640 T5636 dobj signal,harbors
R4520 T5641 T5642 punct (,NLS
R4521 T5642 T5640 appos NLS,signal
R4522 T5643 T5642 punct ),NLS
R4523 T5644 T5640 conj sequence,signal
R4524 T5645 T5644 cc and,sequence
R4525 T5646 T5648 poss its,translocation
R4526 T5647 T5648 amod nuclear,translocation
R4527 T5648 T5649 nsubj translocation,occurs
R4528 T5649 T5649 ROOT occurs,occurs
R4529 T5650 T5649 prep in,occurs
R4618 T5739 T5742 det the,complex
R4619 T5740 T5742 amod cytoplasmic,complex
R4620 T5741 T5742 compound inhibitory,complex
R4621 T5742 T5738 pobj complex,in
R4622 T5743 T5745 punct ",",tested
R4623 T5744 T5745 nsubj we,tested
R4624 T5745 T5720 conj tested,is
R4625 T5746 T5750 mark whether,required
R4626 T5747 T5748 compound IκBα,degradation
R4627 T5748 T5750 nsubjpass degradation,required
R4628 T5749 T5750 auxpass is,required
R4629 T5750 T5745 ccomp required,tested
R4555 T5676 T5677 det this,notion
R4556 T5677 T5675 pobj notion,with
R4557 T5678 T5689 punct ",",enhanced
R4558 T5679 T5680 amod RPS3,association
R4559 T5680 T5689 nsubjpass association,enhanced
R4560 T5681 T5680 prep with,association
R4561 T5682 T5681 pobj importin-α,with
R4562 T5683 T5680 punct ",",association
R4563 T5684 T5680 cc but,association
R4564 T5685 T5686 neg not,importin-β
R4565 T5686 T5680 conj importin-β,association
R4566 T5687 T5689 punct ",",enhanced
R4567 T5688 T5689 auxpass was,enhanced
R4568 T5689 T5689 ROOT enhanced,enhanced
R4569 T5690 T5689 prep in,enhanced
R4570 T5691 T5690 pobj TNF,in
R4584 T5705 T5702 ccomp binding,examined
R4585 T5706 T5707 aux to,importin-α
R4586 T5707 T5705 xcomp importin-α,binding
R4587 T5708 T5708 ROOT is,is
R4588 T5709 T5708 acomp essential,is
R4589 T5710 T5708 prep for,is
R4590 T5711 T5712 amod nuclear,translocation
R4591 T5712 T5710 pobj translocation,for
R4592 T5713 T5712 prep during,translocation
R4593 T5714 T5715 compound NF-κB,activation
R4594 T5715 T5713 pobj activation,during
R4595 T5716 T5708 punct .,is
R4596 T5717 T5720 mark Since,is
R4597 T5718 T5719 compound IκBα,degradation
R4598 T5719 T5720 nsubj degradation,is
R4599 T5720 T5720 ROOT is,is
R4600 T5721 T5722 det a,prerequisite
R4601 T5722 T5720 attr prerequisite,is
R4602 T5723 T5724 aux to,unmask
R4603 T5724 T5722 acl unmask,prerequisite
R4604 T5725 T5726 det the,NLS
R4605 T5726 T5724 dobj NLS,unmask
R4606 T5727 T5726 prep of,NLS
R4607 T5728 T5727 pobj p65,of
R4608 T5729 T5720 punct ",",is
R4609 T5730 T5720 cc and,is
R4610 T5731 T5732 det both,RPS3
R4611 T5732 T5737 dep RPS3,p65
R4612 T5733 T5732 cc and,RPS3
R4613 T5734 T5735 compound IκBα,bind
R4614 T5735 T5732 conj bind,RPS3
R4615 T5736 T5737 aux to,p65
R4616 T5737 T5745 advcl p65,tested
R4617 T5738 T5737 prep in,p65
R4782 T5903 T5899 punct ),detected
R4783 T5904 T5888 punct .,augmented
R4784 T5905 T5925 advmod Moreover,show
R4785 T5906 T5925 punct ",",show
R4786 T5907 T5925 nsubj cells,show
R4787 T5908 T5907 acl treated,cells
R4788 T5909 T5908 prep with,treated
R4789 T5910 T5911 compound sodium,pervanadate
R4790 T5911 T5909 pobj pervanadate,with
R4791 T5912 T5913 punct (,Pv
R4792 T5913 T5911 appos Pv,pervanadate
R4793 T5914 T5908 punct ),treated
R4794 T5915 T5916 aux to,induce
R4795 T5916 T5908 advcl induce,treated
R4796 T5917 T5918 compound IκBα,degradation
R4797 T5918 T5916 dobj degradation,induce
R4798 T5919 T5916 prep through,induce
R4799 T5920 T5922 det an,mechanism25-27
R4800 T5921 T5922 amod IKK-independent,mechanism25-27
R4801 T5922 T5919 pobj mechanism25-27,through
R4802 T5923 T5925 aux did,show
R4803 T5924 T5925 neg not,show
R4804 T5925 T5925 ROOT show,show
R4805 T5926 T5927 amod increased,association
R4806 T5927 T5925 dobj association,show
R4807 T5928 T5927 prep between,association
R4808 T5929 T5928 pobj RPS3,between
R4809 T5930 T5929 cc and,RPS3
R4810 T5931 T5929 conj importin-α,RPS3
R4811 T5932 T5927 punct (,association
R4812 T5933 T5927 appos Fig.,association
R4813 T5934 T5933 nummod 3e,Fig.
R4814 T5935 T5933 cc and,Fig.
R4815 T5936 T5937 compound Supplementary,Fig.
R4816 T5937 T5933 conj Fig.,Fig.
R4817 T5938 T5937 nummod 3b,Fig.
R4818 T5939 T5937 punct ),Fig.
R4819 T5940 T5933 cc or,Fig.
R4820 T5941 T5942 amod nuclear,accumulation
R4821 T5942 T5933 conj accumulation,Fig.
R4630 T5751 T5750 prep for,required
R4631 T5752 T5753 det the,liberation
R4632 T5753 T5751 pobj liberation,for
R4633 T5754 T5753 prep of,liberation
R4634 T5755 T5754 pobj RPS3,of
R4635 T5756 T5745 punct .,tested
R4650 T5771 T5770 cc or,IκBα
R4651 T5772 T5774 det an,mutant
R4652 T5773 T5774 compound IκBα,mutant
R4653 T5774 T5770 conj mutant,IκBα
R4654 T5775 T5776 punct (,SSAA
R4655 T5776 T5774 appos SSAA,mutant
R4656 T5777 T5774 punct ),mutant
R4657 T5778 T5768 conj resistant,overexpressing
R4658 T5779 T5778 prep to,resistant
R4659 T5780 T5781 advmod IKKβ-induced,phosphorylation
R4660 T5781 T5779 pobj phosphorylation,to
R4661 T5782 T5781 cc and,phosphorylation
R4662 T5783 T5781 conj degradation,phosphorylation
R4663 T5784 T5758 punct .,measured
R4664 T5785 T5794 prep In,augmented
R4665 T5786 T5785 pobj cells,In
R4666 T5787 T5786 acl transfected,cells
R4667 T5788 T5787 prep with,transfected
R4668 T5789 T5790 compound wild-type,IκBα
R4669 T5790 T5788 pobj IκBα,with
R4670 T5791 T5794 punct ",",augmented
R4671 T5792 T5793 compound TNF,stimulation
R4672 T5793 T5794 nsubj stimulation,augmented
R4673 T5794 T5794 ROOT augmented,augmented
R4674 T5795 T5796 det the,interaction
R4675 T5796 T5794 dobj interaction,augmented
R4676 T5797 T5796 prep of,interaction
R4677 T5798 T5797 pobj RPS3,of
R4678 T5799 T5798 cc and,RPS3
R4679 T5800 T5794 oprd importin-α,augmented
R4680 T5801 T5794 prep to,augmented
R4681 T5802 T5804 det a,degree
R4682 T5803 T5804 amod similar,degree
R4683 T5804 T5801 pobj degree,to
R4684 T5805 T5804 prep as,degree
R4685 T5806 T5805 prep in,as
R4686 T5807 T5808 amod non-transfected,cells
R4687 T5808 T5806 pobj cells,in
R4688 T5809 T5794 punct .,augmented
R4689 T5810 T5814 prep By,observed
R4690 T5811 T5810 pobj contrast,By
R4691 T5812 T5814 punct ",",observed
R4692 T5813 T5814 nsubj we,observed
R4693 T5814 T5814 ROOT observed,observed
R4694 T5815 T5820 mark that,abolished
R4695 T5816 T5818 det the,association
R4696 T5817 T5818 amod RPS3-importin-α,association
R4697 T5818 T5820 nsubjpass association,abolished
R4698 T5819 T5820 auxpass was,abolished
R4699 T5820 T5814 ccomp abolished,observed
R4700 T5821 T5820 agent by,abolished
R4701 T5822 T5823 det the,presence
R4702 T5823 T5821 pobj presence,by
R4703 T5824 T5823 prep of,presence
R4704 T5825 T5826 compound non-degradable,IκBα
R4705 T5826 T5824 pobj IκBα,of
R4706 T5827 T5830 punct (,)
R4707 T5828 T5830 nmod Fig.,)
R4708 T5829 T5828 nummod 3b,Fig.
R4709 T5830 T5820 punct ),abolished
R4710 T5831 T5814 punct .,observed
R4711 T5832 T5833 aux To,examine
R4712 T5833 T5836 csubj examine,is
R4713 T5834 T5836 mark whether,is
R4714 T5835 T5836 nsubj IκBα,is
R4715 T5836 T5847 advcl is,measured
R4716 T5837 T5840 det the,barrier
R4717 T5838 T5840 amod only,barrier
R4718 T5839 T5840 amod cytoplasmic,barrier
R4719 T5840 T5836 attr barrier,is
R4720 T5841 T5840 acl precluding,barrier
R4721 T5842 T5844 nmod RPS3,translocation
R4722 T5843 T5844 amod nuclear,translocation
R4723 T5844 T5841 dobj translocation,precluding
R4724 T5845 T5847 punct ",",measured
R4725 T5846 T5847 nsubj we,measured
R4726 T5847 T5847 ROOT measured,measured
R4727 T5848 T5850 preconj both,association
R4728 T5849 T5850 compound RPS3-importin-α,association
R4729 T5850 T5847 dobj association,measured
R4730 T5851 T5850 cc and,association
R4731 T5852 T5853 amod nuclear,RPS3
R4732 T5853 T5850 conj RPS3,association
R4733 T5854 T5847 prep after,measured
R4734 T5855 T5854 pcomp reducing,after
R4735 T5856 T5857 compound IκBα,expression
R4736 T5857 T5855 dobj expression,reducing
R4737 T5858 T5847 punct .,measured
R4738 T5859 T5865 amod Compared,targeting
R4739 T5860 T5859 prep with,Compared
R4740 T5861 T5862 compound nonspecific,siRNA
R4741 T5862 T5860 pobj siRNA,with
R4742 T5863 T5862 punct ",",siRNA
R4743 T5864 T5865 compound siRNA,targeting
R4744 T5865 T5869 nsubj targeting,depleted
R4745 T5866 T5865 prep of,targeting
R4746 T5867 T5866 pobj IκBα,of
R4747 T5868 T5869 advmod completely,depleted
R4748 T5869 T5869 ROOT depleted,depleted
R4749 T5870 T5869 dobj IκBα,depleted
R4750 T5871 T5869 prep in,depleted
R4751 T5872 T5873 compound Jurkat,cells
R4752 T5873 T5871 pobj cells,in
R4753 T5874 T5878 punct (,input
R4754 T5875 T5876 compound Fig.,3c
R4755 T5876 T5878 nummod 3c,input
R4756 T5877 T5878 punct ",",input
R4757 T5878 T5869 parataxis input,depleted
R4758 T5879 T5878 punct ),input
R4759 T5880 T5869 punct .,depleted
R4760 T5881 T5888 advmod Nevertheless,augmented
R4761 T5882 T5888 punct ",",augmented
R4762 T5883 T5885 det the,association
R4763 T5884 T5885 amod RPS3-importin-α,association
R4764 T5885 T5888 nsubjpass association,augmented
R4765 T5886 T5888 auxpass was,augmented
R4766 T5887 T5888 neg not,augmented
R4767 T5888 T5888 ROOT augmented,augmented
R4768 T5889 T5888 punct (,augmented
R4769 T5890 T5888 dobj Fig.,augmented
R4770 T5891 T5890 nummod 3c,Fig.
R4771 T5892 T5888 punct ),augmented
R4772 T5893 T5888 punct ",",augmented
R4773 T5894 T5888 cc nor,augmented
R4774 T5895 T5899 auxpass was,detected
R4775 T5896 T5899 amod significant,detected
R4776 T5897 T5898 amod nuclear,RPS3
R4777 T5898 T5899 amod RPS3,detected
R4778 T5899 T5888 conj detected,augmented
R4779 T5900 T5899 punct (,detected
R4780 T5901 T5902 compound Fig.,3d
R4781 T5902 T5899 appos 3d,detected
R4857 T5978 T5958 punct .,examined
R4858 T5979 T5980 nsubj We,found
R4859 T5980 T5980 ROOT found,found
R4860 T5981 T5988 mark that,required
R4861 T5982 T5983 compound TNF,stimulation
R4862 T5983 T5988 nsubjpass stimulation,required
R4863 T5984 T5983 acl following,stimulation
R4864 T5985 T5986 compound Pv,treatment
R4865 T5986 T5984 pobj treatment,following
R4866 T5987 T5988 auxpass was,required
R4867 T5988 T5980 ccomp required,found
R4868 T5989 T5988 prep for,required
R4869 T5990 T5992 det the,association
R4870 T5991 T5992 compound RPS3-importin-α,association
R4871 T5992 T5989 pobj association,for
R4872 T5993 T5992 punct ",",association
R4873 T5994 T5997 amod comparable,stimulation
R4874 T5995 T5994 prep to,comparable
R4875 T5996 T5995 pobj TNF,to
R4876 T5997 T5988 dobj stimulation,required
R4822 T5943 T5942 prep of,accumulation
R4823 T5944 T5943 pobj RPS3,of
R4824 T5945 T5942 punct ",",accumulation
R4825 T5946 T5925 prep despite,show
R4826 T5947 T5949 amod complete,degradation
R4827 T5948 T5949 compound IκBα,degradation
R4828 T5949 T5946 pobj degradation,despite
R4829 T5950 T5952 punct (,Fig.
R4830 T5951 T5952 compound Supplementary,Fig.
R4831 T5952 T5949 appos Fig.,degradation
R4832 T5953 T5952 nummod 3c,Fig.
R4833 T5954 T5952 punct ),Fig.
R4834 T5955 T5925 punct .,show
R4835 T5956 T5958 nsubj We,examined
R4836 T5957 T5958 advmod further,examined
R4837 T5958 T5958 ROOT examined,examined
R4838 T5959 T5966 mark whether,promotes
R4839 T5960 T5964 det a,signal
R4840 T5961 T5964 amod subsequent,signal
R4841 T5962 T5964 compound NF-κB,signal
R4842 T5963 T5964 compound activation,signal
R4843 T5964 T5966 nsubj signal,promotes
R4844 T5965 T5966 advmod independently,promotes
R4845 T5966 T5958 ccomp promotes,examined
R4846 T5967 T5969 det the,association
R4847 T5968 T5969 amod importin-α,association
R4848 T5969 T5966 dobj association,promotes
R4849 T5970 T5969 cc and,association
R4850 T5971 T5972 amod nuclear,transport
R4851 T5972 T5969 conj transport,association
R4852 T5973 T5972 prep of,transport
R4853 T5974 T5973 pobj RPS3,of
R4854 T5975 T5969 prep after,association
R4855 T5976 T5977 compound IκBα,degradation
R4856 T5977 T5975 pobj degradation,after
R6220 T7766 T7772 nsubj protein,lanes
R6221 T7767 T7766 advmod alone,protein
R6222 T7768 T7766 punct (,protein
R6223 T7769 T7770 compound Fig.,4a
R6224 T7770 T7766 appos 4a,protein
R6225 T7771 T7770 punct ",",4a
R6226 T7772 T7731 conj lanes,observed
R6227 T7773 T7776 nmod 3,)
R6228 T7774 T7773 cc and,3
R6229 T7775 T7773 conj 6,3
R6230 T7776 T7772 punct ),lanes
R6231 T7777 T7772 punct ",",lanes
R6232 T7778 T7784 advmod when,used
R6233 T7779 T7780 preconj either,IKKα
R6234 T7780 T7784 nsubjpass IKKα,used
R6235 T7781 T7780 cc or,IKKα
R6236 T7782 T7780 conj IKKβ,IKKα
R6237 T7783 T7784 auxpass was,used
R6238 T7784 T7772 advcl used,lanes
R6239 T7785 T7731 punct .,observed
R6240 T7786 T7787 nsubj We,discovered
R6241 T7787 T7787 ROOT discovered,discovered
R6242 T7788 T7792 mark that,phosphorylated
R6243 T7789 T7792 nsubjpass GST-RPS3,phosphorylated
R6244 T7790 T7792 aux could,phosphorylated
R6245 T7791 T7792 auxpass be,phosphorylated
R6246 T7792 T7787 ccomp phosphorylated,discovered
R6247 T7793 T7792 agent by,phosphorylated
R6248 T7794 T7793 pobj IKKβ,by
R6249 T7795 T7792 punct ",",phosphorylated
R6250 T7796 T7792 cc but,phosphorylated
R6251 T7797 T7798 neg not,IKKα
R6252 T7798 T7806 nsubj IKKα,compare
R6253 T7799 T7798 punct ",",IKKα
R6254 T7800 T7798 prep in,IKKα
R6255 T7801 T7800 amod vitro,in
R6256 T7802 T7798 punct (,IKKα
R6257 T7803 T7798 conj Fig.,IKKα
R6258 T7804 T7803 nummod 4a,Fig.
R6259 T7805 T7798 punct ",",IKKα
R6260 T7806 T7792 conj compare,phosphorylated
R6261 T7807 T7806 dobj lanes,compare
R6262 T7808 T7807 nummod 4,lanes
R6263 T7809 T7808 cc and,4
R6264 T7810 T7808 conj 7,4
R6265 T7811 T7806 punct ),compare
R6266 T7812 T7787 punct .,discovered
R6267 T7813 T7814 aux To,identify
R6268 T7814 T7823 advcl identify,phosphorylated
R6269 T7815 T7819 det the,residue
R6270 T7816 T7819 amod RPS3,residue
R6271 T7817 T7819 amod amino,residue
R6272 T7818 T7819 compound acid,residue
R6273 T7819 T7814 dobj residue,identify
R6274 T7820 T7819 punct (,residue
R4877 T5998 T5997 advmod alone,stimulation
R4878 T5999 T5997 punct (,stimulation
R4879 T6000 T5997 appos Fig.,stimulation
R4880 T6001 T6000 nummod 3e,Fig.
R4881 T6002 T5997 punct ),stimulation
R4882 T6003 T5980 punct .,found
R4883 T6004 T6012 advmod Thus,required
R4884 T6005 T6012 punct ",",required
R4885 T6006 T6007 compound IκBα,phosphorylation
R4886 T6007 T6012 nsubjpass phosphorylation,required
R4887 T6008 T6007 cc and,phosphorylation
R4888 T6009 T6007 conj degradation,phosphorylation
R4889 T6010 T6009 appos itself,degradation
R4890 T6011 T6012 auxpass is,required
R4891 T6012 T6012 ROOT required,required
R4892 T6013 T6012 cc but,required
R4893 T6014 T6015 neg not,sufficient
R4894 T6015 T6012 conj sufficient,required
R4895 T6016 T6017 aux to,cause
R4896 T6017 T6015 xcomp cause,sufficient
R4897 T6018 T6019 amod RPS3,association
R4898 T6019 T6017 dobj association,cause
R4899 T6020 T6019 prep with,association
R4900 T6021 T6022 amod importin-α,followed
R4901 T6022 T6020 pcomp followed,with
R4902 T6023 T6022 agent by,followed
R4903 T6024 T6025 amod nuclear,translocation
R4904 T6025 T6023 pobj translocation,by
R4905 T6026 T6012 punct .,required
R4906 T6027 T6040 advmod Rather,required
R4907 T6028 T6040 punct ",",required
R4908 T6029 T6031 det an,signal
R4909 T6030 T6031 amod additional,signal
R4910 T6031 T6040 nsubjpass signal,required
R4911 T6032 T6035 punct ",",phosphorylation
R4912 T6033 T6035 advmod potentially,phosphorylation
R4913 T6034 T6035 compound IKKβ,phosphorylation
R4914 T6035 T6031 appos phosphorylation,signal
R4915 T6036 T6035 prep of,phosphorylation
R4916 T6037 T6036 pobj RPS3,of
R4917 T6038 T6040 punct ",",required
R4918 T6039 T6040 auxpass is,required
R4919 T6040 T6040 ROOT required,required
R4920 T6041 T6040 punct .,required
R6125 T7671 T7672 nsubj IKKβ,phosphorylates
R6126 T7672 T7672 ROOT phosphorylates,phosphorylates
R6127 T7673 T7672 dobj RPS3,phosphorylates
R6128 T7674 T7672 prep at,phosphorylates
R6129 T7675 T7674 pobj serine,at
R6130 T7676 T7675 nummod 209,serine
R6131 T7677 T7679 mark Although,defined
R6132 T7678 T7679 advmod originally,defined
R6133 T7679 T7689 advcl defined,phosphorylates
R6134 T7680 T7679 prep as,defined
R6135 T7681 T7682 det the,kinase
R6136 T7682 T7680 pobj kinase,as
R6137 T7683 T7684 nsubj that,phosphorylates
R6138 T7684 T7682 relcl phosphorylates,kinase
R6139 T7685 T7684 dobj IκB19,phosphorylates
R6140 T7686 T7689 punct ",",phosphorylates
R6141 T7687 T7689 nsubj IKKβ,phosphorylates
R6142 T7688 T7689 advmod also,phosphorylates
R6143 T7689 T7689 ROOT phosphorylates,phosphorylates
R6144 T7690 T7691 amod unrelated,substrates
R6145 T7691 T7689 dobj substrates,phosphorylates
R6146 T7692 T7691 prep including,substrates
R6147 T7693 T7692 pobj 14-3-3β,including
R6148 T7694 T7693 cc and,14-3-3β
R6149 T7695 T7693 conj Bcl10,14-3-3β
R6150 T7696 T7693 punct ",",14-3-3β
R6151 T7697 T7698 nsubj which,lack
R6152 T7698 T7693 relcl lack,14-3-3β
R6153 T7699 T7702 det the,motif
R6154 T7700 T7702 compound IKK,motif
R6155 T7701 T7702 compound consensus,motif
R6156 T7702 T7698 dobj motif,lack
R6157 T7703 T7704 punct (,DpSGYXpS/T
R6158 T7704 T7702 appos DpSGYXpS/T,motif
R6159 T7705 T7704 punct ),DpSGYXpS/T
R6160 T7706 T7702 appos 28,motif
R6161 T7707 T7689 punct .,phosphorylates
R6162 T7708 T7710 nsubj We,hypothesized
R6163 T7709 T7710 advmod therefore,hypothesized
R6164 T7710 T7710 ROOT hypothesized,hypothesized
R6165 T7711 T7715 mark that,phosphorylate
R6166 T7712 T7715 nsubj IKKβ,phosphorylate
R6167 T7713 T7715 aux could,phosphorylate
R6168 T7714 T7715 advmod directly,phosphorylate
R6169 T7715 T7710 ccomp phosphorylate,hypothesized
R6170 T7716 T7715 dobj RPS3,phosphorylate
R6171 T7717 T7710 punct .,hypothesized
R6172 T7718 T7731 prep By,observed
R6173 T7719 T7731 prep in,observed
R6174 T7720 T7722 amod vitro,assays
R6175 T7721 T7722 compound kinase,assays
R6176 T7722 T7719 pobj assays,in
R6177 T7723 T7722 acl using,assays
R6178 T7724 T7725 amod recombinant,IKK
R6179 T7725 T7728 nmod IKK,proteins
R6180 T7726 T7725 cc and,IKK
R6181 T7727 T7725 conj RPS3,IKK
R6182 T7728 T7723 dobj proteins,using
R6183 T7729 T7731 punct ",",observed
R6184 T7730 T7731 nsubj we,observed
R6185 T7731 T7731 ROOT observed,observed
R6186 T7732 T7733 amod strong,incorporation
R6187 T7733 T7731 dobj incorporation,observed
R6188 T7734 T7733 prep of,incorporation
R6189 T7735 T7734 pobj 32P,of
R6190 T7736 T7731 prep in,observed
R6191 T7737 T7738 compound autophosphorylatd,IKKα
R6192 T7738 T7745 nmod IKKα,lanes
R6193 T7739 T7738 cc and,IKKα
R6194 T7740 T7738 conj IKKβ,IKKα
R6195 T7741 T7742 punct (,Fig.
R6196 T7742 T7740 appos Fig.,IKKβ
R6197 T7743 T7742 nummod 4a,Fig.
R6198 T7744 T7740 punct ",",IKKβ
R6199 T7745 T7736 pobj lanes,in
R6200 T7746 T7731 advcl 2-7,observed
R6201 T7747 T7746 punct ),2-7
R6202 T7748 T7750 advmod as,as
R6203 T7749 T7750 advmod well,as
R6204 T7750 T7746 cc as,2-7
R6205 T7751 T7752 compound phosporylated,GST-IκBα
R6206 T7752 T7752 ROOT GST-IκBα,GST-IκBα
R6207 T7753 T7752 punct (,GST-IκBα
R6208 T7754 T7752 appos 1-54,GST-IκBα
R6209 T7755 T7752 punct ),GST-IκBα
R6210 T7756 T7752 punct (,GST-IκBα
R6211 T7757 T7758 compound Supplementary,Fig.
R6212 T7758 T7752 appos Fig.,GST-IκBα
R6213 T7759 T7758 nummod 4,Fig.
R6214 T7760 T7752 punct ),GST-IκBα
R6215 T7761 T7752 punct ",",GST-IκBα
R6216 T7762 T7731 cc but,observed
R6217 T7763 T7766 neg not,protein
R6218 T7764 T7766 det the,protein
R6219 T7765 T7766 compound GST,protein
R6295 T7841 T7842 nsubj results,indicated
R6296 T7842 T7842 ROOT indicated,indicated
R6297 T7843 T7845 mark that,phosphorylated
R6298 T7844 T7845 nsubj IKKβ,phosphorylated
R6299 T7845 T7842 ccomp phosphorylated,indicated
R6300 T7846 T7845 dobj S209,phosphorylated
R6301 T7847 T7846 punct ",",S209
R6302 T7848 T7846 acl located,S209
R6303 T7849 T7848 prep in,located
R6304 T7850 T7852 det the,C-terminus
R6305 T7851 T7852 compound RPS3,C-terminus
R6306 T7852 T7849 pobj C-terminus,in
R6307 T7853 T7852 punct (,C-terminus
R6308 T7854 T7852 appos Fig.,C-terminus
R6309 T7855 T7854 nummod 4b,Fig.
R6310 T7856 T7852 punct ),C-terminus
R6311 T7857 T7842 punct .,indicated
R6312 T7858 T7862 nummod RPS3,alignment
R6313 T7859 T7862 compound amino,alignment
R6275 T7821 T7819 appos s,residue
R6276 T7822 T7819 punct ),residue
R6277 T7823 T7828 advcl phosphorylated,performed
R6278 T7824 T7823 agent by,phosphorylated
R6279 T7825 T7824 pobj IKKβ,by
R6280 T7826 T7828 punct ",",performed
R6281 T7827 T7828 nsubj we,performed
R6282 T7828 T7828 ROOT performed,performed
R6283 T7829 T7833 amod liquid,analyses
R6284 T7830 T7833 nmod chromatography-tandem,analyses
R6285 T7831 T7833 nmod mass,analyses
R6286 T7832 T7833 compound spectrometry,analyses
R6287 T7833 T7828 dobj analyses,performed
R6288 T7834 T7833 acl using,analyses
R6289 T7835 T7834 prep in,using
R6290 T7836 T7835 pobj vitro,in
R6291 T7837 T7838 amod phosphorylated,RPS3
R6292 T7838 T7834 dobj RPS3,using
R6293 T7839 T7828 punct .,performed
R6294 T7840 T7841 det The,results
R6370 T7916 T7915 prep with,assays
R6371 T7917 T7923 amod recombinant,proteins
R6372 T7918 T7923 amod wild-type,proteins
R6373 T7919 T7918 cc or,wild-type
R6374 T7920 T7918 conj S209A,wild-type
R6375 T7921 T7923 amod mutant,proteins
R6376 T7922 T7923 compound RPS3,proteins
R6377 T7923 T7916 pobj proteins,with
R6378 T7924 T7910 punct .,performed
R6379 T7925 T7934 prep Compared,reduced
R6380 T7926 T7925 prep with,Compared
R6381 T7927 T7929 det the,protein
R6382 T7928 T7929 amod wild-type,protein
R6383 T7929 T7926 pobj protein,with
R6384 T7930 T7934 punct ",",reduced
R6385 T7931 T7933 det the,mutation
R6386 T7932 T7933 compound S209A,mutation
R6387 T7933 T7934 nsubj mutation,reduced
R6388 T7934 T7934 ROOT reduced,reduced
R6389 T7935 T7934 dobj IKKβ,reduced
R6390 T7936 T7934 conj mediated,reduced
R6391 T7937 T7938 amod RPS3,phosphorylation
R6392 T7938 T7936 dobj phosphorylation,mediated
R6393 T7939 T7940 punct (,Fig.
R6394 T7940 T7938 appos Fig.,phosphorylation
R6395 T7941 T7940 nummod 4c,Fig.
R6396 T7942 T7938 punct ),phosphorylation
R6397 T7943 T7934 punct .,reduced
R6398 T7944 T7946 expl There,be
R6399 T7945 T7946 aux might,be
R6400 T7946 T7946 ROOT be,be
R6401 T7947 T7949 amod alternative,site
R6402 T7948 T7949 compound phosphorylation,site
R6403 T7949 T7946 attr site,be
R6404 T7950 T7949 punct (,site
R6405 T7951 T7949 appos s,site
R6406 T7952 T7949 punct ),site
R6407 T7953 T7946 prep under,be
R6408 T7954 T7955 det these,conditions
R6409 T7955 T7953 pobj conditions,under
R6410 T7956 T7946 prep given,be
R6411 T7957 T7960 amod modest,RPS3
R6412 T7958 T7960 amod residual,RPS3
R6413 T7959 T7960 amod phosphorylated,RPS3
R6414 T7960 T7956 pobj RPS3,given
R6415 T7961 T7960 punct (,RPS3
R6416 T7962 T7960 appos Fig.,RPS3
R6417 T7963 T7962 nummod 4c,Fig.
R6418 T7964 T7960 punct ),RPS3
R6419 T7965 T7946 punct .,be
R6420 T7966 T7967 nummod RPS3,S209
R6421 T7967 T7970 nsubj S209,fall
R6422 T7968 T7970 aux does,fall
R6423 T7969 T7970 neg not,fall
R6424 T7970 T7970 ROOT fall,fall
R6425 T7971 T7970 prep within,fall
R6426 T7972 T7976 det a,motif
R6427 T7973 T7976 amod conventional,motif
R6428 T7974 T7976 compound IKK,motif
R6429 T7975 T7976 compound recognition,motif
R6430 T7976 T7971 pobj motif,within
R6431 T7977 T7970 punct ",",fall
R6432 T7978 T7970 cc but,fall
R6433 T7979 T7980 advmod rather,resides
R6434 T7980 T7970 conj resides,fall
R6435 T7981 T7980 prep in,resides
R6436 T7982 T7984 det a,motif
R6437 T7983 T7984 compound sequence,motif
R6438 T7984 T7981 pobj motif,in
R6439 T7985 T7986 punct (,XXXpS/TXXE
R6440 T7986 T7984 appos XXXpS/TXXE,motif
R6441 T7987 T7986 punct ),XXXpS/TXXE
R6442 T7988 T7980 punct ",",resides
R6443 T7989 T7990 advmod potentially,recognized
R6314 T7860 T7861 compound acid,sequence
R6315 T7861 T7862 compound sequence,alignment
R6316 T7862 T7863 nsubj alignment,revealed
R6317 T7863 T7863 ROOT revealed,revealed
R6318 T7864 T7867 mark that,conserved
R6319 T7865 T7867 nsubjpass S209,conserved
R6320 T7866 T7867 auxpass is,conserved
R6321 T7867 T7863 ccomp conserved,revealed
R6322 T7868 T7867 prep in,conserved
R6323 T7869 T7870 amod many,species
R6324 T7870 T7868 pobj species,in
R6325 T7871 T7870 prep throughout,species
R6326 T7872 T7871 pobj phylogeny,throughout
R6327 T7873 T7867 prep with,conserved
R6328 T7874 T7875 det the,exception
R6329 T7875 T7873 pobj exception,with
R6330 T7876 T7875 prep of,exception
R6331 T7877 T7878 compound Caenorhabditis,elegans
R6332 T7878 T7876 pobj elegans,of
R6333 T7879 T7878 cc and,elegans
R6334 T7880 T7878 conj Schizosaccharomyces,elegans
R6335 T7881 T7878 conj pombe,elegans
R6336 T7882 T7881 punct ",",pombe
R6337 T7883 T7884 nummod two,organisms
R6338 T7884 T7878 appos organisms,elegans
R6339 T7885 T7888 nsubj that,possess
R6340 T7886 T7888 aux do,possess
R6341 T7887 T7888 neg not,possess
R6342 T7888 T7884 relcl possess,organisms
R6343 T7889 T7892 det the,pathway
R6344 T7890 T7892 amod NF-κB,pathway
R6345 T7891 T7892 compound signal,pathway
R6346 T7892 T7888 dobj pathway,possess
R6347 T7893 T7892 punct (,pathway
R6348 T7894 T7895 compound Supplementary,Fig.
R6349 T7895 T7892 appos Fig.,pathway
R6350 T7896 T7895 nummod 5,Fig.
R6351 T7897 T7892 punct ),pathway
R6352 T7898 T7863 punct .,revealed
R6353 T7899 T7900 aux To,verify
R6354 T7900 T7910 advcl verify,performed
R6355 T7901 T7900 advmod biochemically,verify
R6356 T7902 T7904 mark that,is
R6357 T7903 T7904 nsubj S209,is
R6358 T7904 T7901 ccomp is,biochemically
R6359 T7905 T7907 det an,substrate
R6360 T7906 T7907 amod IKKβ,substrate
R6361 T7907 T7904 attr substrate,is
R6362 T7908 T7910 punct ",",performed
R6363 T7909 T7910 nsubj we,performed
R6364 T7910 T7910 ROOT performed,performed
R6365 T7911 T7910 dobj 32P-labeling,performed
R6366 T7912 T7910 prep in,performed
R6367 T7913 T7915 amod vitro,assays
R6368 T7914 T7915 compound kinase,assays
R6369 T7915 T7912 pobj assays,in
R6445 T7991 T7990 agent by,recognized
R6446 T7992 T7994 amod casein,II
R6447 T7993 T7994 compound kinase,II
R6448 T7994 T7991 pobj II,by
R6449 T7995 T7994 punct (,II
R6450 T7996 T7994 appos CK2,II
R6451 T7997 T7994 punct ),II
R6452 T7998 T7970 punct .,fall
R6453 T7999 T8003 mark Although,display
R6454 T8000 T8001 compound IKKβ,kinase
R6455 T8001 T8003 nsubj kinase,display
R6456 T8002 T8003 aux can,display
R6457 T8003 T8012 advcl display,was
R6458 T8004 T8007 det a,specificity29
R6459 T8005 T8007 nummod CK2-like,specificity29
R6460 T8006 T8007 compound phosphorylation,specificity29
R6461 T8007 T8003 dobj specificity29,display
R6462 T8008 T8012 punct ",",was
R6463 T8009 T8011 det no,protein
R6501 T8047 T8044 acl bound,amount
R6502 T8048 T8047 prep to,bound
R6503 T8049 T8048 pobj IKKs,to
R6504 T8050 T8030 punct .,was
R6505 T8051 T8052 aux To,determine
R6506 T8052 T8069 advcl determine,transfected
R6507 T8053 T8055 mark whether,is
R6508 T8054 T8055 nsubj S209,is
R6509 T8055 T8052 ccomp is,determine
R6510 T8056 T8058 det the,site
R6511 T8057 T8058 amod critical,site
R6512 T8058 T8055 attr site,is
R6513 T8059 T8062 prep at,phosphorylates
R6514 T8060 T8059 pobj which,at
R6515 T8061 T8062 nsubj IKKβ,phosphorylates
R6516 T8062 T8058 relcl phosphorylates,site
R6517 T8063 T8062 dobj RPS3,phosphorylates
R6518 T8064 T8062 prep in,phosphorylates
R6519 T8065 T8066 amod living,cells
R6520 T8066 T8064 pobj cells,in
R6521 T8067 T8069 punct ",",transfected
R6522 T8068 T8069 nsubj we,transfected
R6523 T8069 T8069 ROOT transfected,transfected
R6524 T8070 T8075 det the,Flag-RPS3
R6525 T8071 T8075 amod wild-type,Flag-RPS3
R6526 T8072 T8071 cc or,wild-type
R6527 T8073 T8071 conj S209A,wild-type
R6528 T8074 T8075 amod mutant,Flag-RPS3
R6529 T8075 T8069 dobj Flag-RPS3,transfected
R6530 T8076 T8069 advmod alone,transfected
R6531 T8077 T8069 punct ",",transfected
R6532 T8078 T8069 cc or,transfected
R6533 T8079 T8080 advmod together,with
R6534 T8080 T8069 conj with,transfected
R6535 T8081 T8080 pobj IKKβ,with
R6536 T8082 T8080 conj into,with
R6537 T8083 T8082 pobj cells,into
R6538 T8084 T8069 punct .,transfected
R6539 T8085 T8088 advmod Indeed,observed
R6540 T8086 T8088 punct ",",observed
R6541 T8087 T8088 nsubj we,observed
R6560 T8106 T8107 nsubj S209,is
R6561 T8107 T8104 ccomp is,indicating
R6562 T8108 T8111 det the,site
R6563 T8109 T8111 amod predominant,site
R6564 T8110 T8111 compound target,site
R6565 T8111 T8107 attr site,is
R6566 T8112 T8111 prep for,site
R6567 T8113 T8114 compound IKKβ,phosphorylation
R6568 T8114 T8112 pobj phosphorylation,for
R6569 T8115 T8116 punct (,Fig.
R6570 T8116 T8114 appos Fig.,phosphorylation
R6571 T8117 T8116 nummod 4d,Fig.
R6572 T8118 T8100 punct ),eliminated
R6573 T8119 T8088 punct .,observed
R6574 T8120 T8122 nsubj We,generated
R6575 T8121 T8122 advmod next,generated
R6576 T8122 T8122 ROOT generated,generated
R6577 T8123 T8126 det a,antibody
R6578 T8124 T8126 amod phospho-S209,antibody
R6579 T8125 T8126 compound RPS3,antibody
R6580 T8126 T8122 dobj antibody,generated
R6581 T8127 T8122 cc and,generated
R6582 T8128 T8122 conj confirmed,generated
R6583 T8129 T8133 mark that,phosphorylated
R6584 T8130 T8131 amod endogenous,RPS3
R6585 T8131 T8133 nsubjpass RPS3,phosphorylated
R6586 T8132 T8133 auxpass was,phosphorylated
R6587 T8133 T8128 ccomp phosphorylated,confirmed
R6588 T8134 T8133 prep at,phosphorylated
R6589 T8135 T8134 pobj S209,at
R6590 T8136 T8133 prep in,phosphorylated
R6591 T8137 T8139 det a,manner
R6592 T8138 T8139 amod time-dependent,manner
R6593 T8139 T8136 pobj manner,in
R6594 T8140 T8139 prep upon,manner
R6595 T8141 T8142 compound TNF,stimulation
R6596 T8142 T8140 pobj stimulation,upon
R6597 T8143 T8133 punct (,phosphorylated
R6598 T8144 T8133 dep Fig.,phosphorylated
R6599 T8145 T8144 nummod 4e,Fig.
R6600 T8146 T8133 punct ),phosphorylated
R6601 T8147 T8122 punct .,generated
R6444 T7990 T7970 conj recognized,fall
R7947 T9891 T9892 amod RPS3-transfected,cells
R7948 T9892 T9885 pobj cells,from
R7949 T9893 T9894 auxpass were,prepared
R7950 T9894 T9894 ROOT prepared,prepared
R7951 T9895 T9894 cc and,prepared
R7952 T9896 T9894 conj blotted,prepared
R7953 T9897 T9896 prep for,blotted
R7954 T9898 T9899 compound heat-shock,protein
R7955 T9899 T9897 pobj protein,for
R7956 T9900 T9899 nummod 90,protein
R7957 T9901 T9899 punct (,protein
R7958 T9902 T9899 appos hsp90,protein
R7959 T9903 T9899 punct ),protein
R7960 T9904 T9896 punct ",",blotted
R7961 T9905 T9907 det a,protein
R7962 T9906 T9907 amod cytoplasmic,protein
R7963 T9907 T9896 conj protein,blotted
R7964 T9908 T9907 punct ",",protein
R7965 T9909 T9907 cc and,protein
R7966 T9910 T9907 conj poly,protein
R7967 T9911 T9910 punct (,poly
R7968 T9912 T9910 appos ADP-ribose,poly
R7969 T9913 T9910 punct ),poly
R7970 T9914 T9907 conj polymerase,protein
R7971 T9915 T9914 punct (,polymerase
R7972 T9916 T9914 appos PARP,polymerase
R7973 T9917 T9914 punct ),polymerase
R7974 T9918 T9914 punct ",",polymerase
R7975 T9919 T9921 det a,protein
R7976 T9920 T9921 amod nuclear,protein
R7977 T9921 T9907 appos protein,protein
R7978 T9922 T9907 punct ",",protein
R7979 T9923 T9907 acl confirming,protein
R7980 T9924 T9926 det a,separation
R7981 T9925 T9926 amod clean,separation
R7982 T9926 T9923 dobj separation,confirming
R7983 T9927 T9926 punct (,separation
R7984 T9928 T9926 appos Fig.,separation
R7985 T9929 T9928 nummod 5a,Fig.
R7986 T9930 T9926 punct ),separation
R7987 T9931 T9894 punct .,prepared
R7988 T9932 T9933 mark As,expected
R7989 T9933 T9937 advcl expected,triggered
R7990 T9934 T9937 punct ",",triggered
R7991 T9935 T9936 compound PMA+I,stimulation
R7992 T9936 T9937 nsubj stimulation,triggered
R7993 T9937 T9937 ROOT triggered,triggered
R7994 T9938 T9941 nmod wild-type,translocation
R7995 T9939 T9941 nmod Flag-RPS3,translocation
R7996 T9940 T9941 amod nuclear,translocation
R7997 T9941 T9937 dobj translocation,triggered
R7998 T9942 T9941 punct (,translocation
R7999 T9943 T9941 appos Fig.,translocation
R8000 T9944 T9943 nummod 5a,Fig.
R8001 T9945 T9941 punct ),translocation
R8002 T9946 T9937 punct .,triggered
R8003 T9947 T9955 advmod However,was
R8004 T9948 T9955 punct ",",was
R8005 T9949 T9954 nmod RPS3,translocation
R8006 T9950 T9951 punct (,S209A
R8007 T9951 T9954 nmod S209A,translocation
R8008 T9952 T9951 punct ),S209A
R8009 T9953 T9954 amod nuclear,translocation
R8010 T9954 T9955 nsubj translocation,was
R8011 T9955 T9955 ROOT was,was
R8012 T9956 T9955 acomp attenuated,was
R8013 T9957 T9956 punct (,attenuated
R8014 T9958 T9960 nmod Fig.,)
R8015 T9959 T9958 nummod 5a,Fig.
R8016 T9960 T9956 punct ),attenuated
R8017 T9961 T9955 punct .,was
R8018 T9962 T9964 nsubj We,tested
R8019 T9963 T9964 advmod also,tested
R8020 T9964 T9964 ROOT tested,tested
R8021 T9965 T9966 det the,impact
R8171 T10115 T10111 dobj UTR,lacking
R8172 T10116 T10117 punct (,Fig.
R8173 T10117 T10115 appos Fig.,UTR
R8174 T10118 T10117 nummod 5c,Fig.
R8175 T10119 T10115 punct ),UTR
R8176 T10120 T10088 punct .,reduced
R8177 T10121 T10123 nsubj We,found
R8178 T10122 T10123 advmod also,found
R8179 T10123 T10123 ROOT found,found
R8180 T10124 T10134 mark that,luciferase
R8181 T10125 T10129 nummod RPS3,expression
R8182 T10126 T10129 amod knockdown,expression
R8183 T10127 T10129 amod reduced,expression
R8184 T10128 T10129 amod TNF-induced,expression
R8185 T10129 T10134 nsubj expression,luciferase
R8186 T10130 T10129 prep of,expression
R6602 T8148 T8155 advmod Thus,contains
R6603 T8149 T8155 punct ",",contains
R6604 T8150 T8155 advmod the,contains
R6605 T8151 T8155 nsubj RPS3,contains
R6606 T8152 T8155 nsubj C-terminal,contains
R6607 T8153 T8155 nsubj tail,contains
R6608 T8154 T8155 advmod potentially,contains
R6609 T8155 T8155 ROOT contains,contains
R6610 T8156 T8159 det an,site
R6611 T8157 T8159 amod important,site
R6612 T8158 T8159 amod regulatory,site
R6613 T8159 T8155 dobj site,contains
R6614 T8160 T8155 punct .,contains
R7913 T9857 T9870 nsubj Phosphorylation,plays
R7914 T9858 T9857 prep of,Phosphorylation
R7915 T9859 T9858 pobj RPS3,of
R7916 T9860 T9857 cc and,Phosphorylation
R7917 T9861 T9863 poss its,function
R7918 T9862 T9863 amod NF-κB,function
R7919 T9863 T9857 conj function,Phosphorylation
R7920 T9864 T9866 nsubj We,examined
R7921 T9865 T9866 advmod next,examined
R7922 T9866 T9857 relcl examined,Phosphorylation
R7923 T9867 T9870 mark whether,plays
R7924 T9868 T9869 compound S209,phosphorylation
R7925 T9869 T9870 nsubj phosphorylation,plays
R7926 T9870 T9870 ROOT plays,plays
R7927 T9871 T9872 det a,role
R7928 T9872 T9870 dobj role,plays
R7929 T9873 T9872 prep in,role
R7930 T9874 T9876 det the,translocation
R7931 T9875 T9876 amod nuclear,translocation
R7932 T9876 T9873 pobj translocation,in
R7933 T9877 T9876 prep of,translocation
R7934 T9878 T9877 pobj RPS3,of
R7935 T9879 T9872 prep during,role
R7936 T9880 T9881 amod NF-κB,activation
R7937 T9881 T9879 pobj activation,during
R7938 T9882 T9870 punct .,plays
R7939 T9883 T9884 amod Subcellular,fractions
R7940 T9884 T9894 nsubjpass fractions,prepared
R7941 T9885 T9884 prep from,fractions
R7942 T9886 T9887 preconj either,wild-type
R7943 T9887 T9892 nmod wild-type,cells
R7944 T9888 T9887 cc or,wild-type
R7945 T9889 T9890 advmod S209A,mutant
R7946 T9890 T9887 conj mutant,wild-type
R8022 T9966 T9964 dobj impact,tested
R8023 T9967 T9966 prep of,impact
R8024 T9968 T9967 pcomp activating,of
R8025 T9969 T9968 dobj NF-κB,activating
R8026 T9970 T9968 prep by,activating
R8027 T9971 T9970 pcomp overexpressing,by
R8028 T9972 T9971 dobj IKKβ,overexpressing
R8029 T9973 T9971 prep on,overexpressing
R8030 T9974 T9976 nmod RPS3,translocation
R8031 T9975 T9976 amod nuclear,translocation
R8032 T9976 T9973 pobj translocation,on
R8033 T9977 T9964 punct .,tested
R8034 T9978 T9979 compound IKKβ,overexpression
R8035 T9979 T9982 nsubjpass overexpression,measured
R8036 T9980 T9982 aux activated,measured
R8037 T9981 T9982 advmod NF-κB,measured
R8038 T9982 T9982 ROOT measured,measured
R8039 T9983 T9982 agent by,measured
R8040 T9984 T9985 compound luciferase,assays
R8041 T9985 T9983 pobj assays,by
R8042 T9986 T9988 punct (,Fig.
R8043 T9987 T9988 compound Supplementary,Fig.
R8044 T9988 T9985 appos Fig.,assays
R8045 T9989 T9988 nummod 7,Fig.
R8046 T9990 T9988 punct ),Fig.
R8047 T9991 T9985 punct ",",assays
R8048 T9992 T9982 cc and,measured
R8049 T9993 T9994 advmod also,induced
R8050 T9994 T9982 conj induced,measured
R8051 T9995 T9997 det the,translocation
R8052 T9996 T9997 amod nuclear,translocation
R8053 T9997 T9994 dobj translocation,induced
R8054 T9998 T9997 prep of,translocation
R8055 T9999 T9998 pobj wild-type,of
R8056 T10000 T9994 punct ",",induced
R8057 T10001 T9994 cc but,induced
R8058 T10002 T10003 neg not,S209A
R8059 T10003 T9994 conj S209A,induced
R8060 T10004 T10003 punct ",",S209A
R8061 T10005 T10003 conj RPS3,S209A
R8062 T10006 T10005 punct (,RPS3
R8063 T10007 T10005 appos Fig.,RPS3
R8064 T10008 T10007 nummod 5b,Fig.
R8065 T10009 T10005 punct ),RPS3
R8066 T10010 T9982 punct .,measured
R8067 T10011 T10012 det These,data
R8068 T10012 T10013 nsubj data,suggest
R8069 T10013 T10013 ROOT suggest,suggest
R8070 T10014 T10017 mark that,is
R8071 T10015 T10016 nummod S209,phosphorylation
R8072 T10016 T10017 nsubj phosphorylation,is
R8073 T10017 T10013 ccomp is,suggest
R8074 T10018 T10017 acomp critical,is
R8075 T10019 T10018 prep for,critical
R8076 T10020 T10021 det the,NF-κB
R8077 T10021 T10019 pobj NF-κB,for
R8078 T10022 T10025 amod activation-induced,translocation
R8079 T10023 T10025 nummod RPS3,translocation
R8080 T10024 T10025 amod nuclear,translocation
R8081 T10025 T10017 dobj translocation,is
R8082 T10026 T10013 punct .,suggest
R8083 T10027 T10028 aux To,examine
R8084 T10028 T10046 advcl examine,silenced
R8085 T10029 T10030 det the,role
R8086 T10030 T10028 dobj role,examine
R8087 T10031 T10030 prep of,role
R8088 T10032 T10033 nummod S209,phosphorylation
R8089 T10033 T10031 pobj phosphorylation,of
R8090 T10034 T10033 prep of,phosphorylation
R8091 T10035 T10034 pobj RPS3,of
R8092 T10036 T10046 prep to,silenced
R8093 T10037 T10039 poss its,function6
R8094 T10038 T10039 compound NF-κB,function6
R8095 T10039 T10036 pobj function6,to
R8096 T10040 T10039 punct ",",function6
R8097 T10041 T10039 appos 7,function6
R8098 T10042 T10039 punct ",",function6
R8099 T10043 T10039 appos 30,function6
R8100 T10044 T10046 punct ",",silenced
R8101 T10045 T10046 nsubj we,silenced
R8102 T10046 T10046 ROOT silenced,silenced
R8103 T10047 T10049 amod endogenous,expression
R8104 T10048 T10049 compound RPS3,expression
R8105 T10049 T10046 dobj expression,silenced
R8106 T10050 T10046 advcl using,silenced
R8107 T10051 T10052 det an,siRNA
R8108 T10052 T10050 dobj siRNA,using
R8109 T10053 T10054 nsubj that,targets
R8110 T10054 T10052 relcl targets,siRNA
R8111 T10055 T10059 det the,region
R8112 T10056 T10057 nummod 3,′
R8113 T10057 T10059 nmod ′,region
R8114 T10058 T10059 amod untranslated,region
R8115 T10059 T10054 dobj region,targets
R8116 T10060 T10059 punct (,region
R8117 T10061 T10062 nummod 3,′
R8118 T10062 T10063 nummod ′,UTR
R8119 T10063 T10059 appos UTR,region
R8120 T10064 T10059 punct ),region
R8121 T10065 T10059 prep of,region
R8122 T10066 T10067 nummod RPS3,mRNA
R8123 T10067 T10065 pobj mRNA,of
R8124 T10068 T10046 punct ",",silenced
R8125 T10069 T10046 advcl followed,silenced
R8126 T10070 T10069 agent by,followed
R8127 T10071 T10070 pobj complementation,by
R8128 T10072 T10069 prep with,followed
R8129 T10073 T10074 preconj either,wild-type
R8130 T10074 T10078 amod wild-type,RPS3
R8131 T10075 T10074 cc or,wild-type
R8132 T10076 T10074 conj S209A,wild-type
R8187 T10131 T10133 det an,κB-driven
R8188 T10132 T10133 compound Ig,κB-driven
R8189 T10133 T10130 pobj κB-driven,of
R8190 T10134 T10123 ccomp luciferase,found
R8191 T10135 T10134 npadvmod construct6,luciferase
R8192 T10136 T10139 punct (,)
R8193 T10137 T10139 nmod Fig.,)
R8194 T10138 T10137 nummod 5d,Fig.
R8195 T10139 T10123 punct ),found
R8196 T10140 T10123 punct .,found
R8197 T10141 T10144 det The,signal
R8198 T10142 T10144 amod impaired,signal
R8199 T10143 T10144 compound luciferase,signal
R8200 T10144 T10151 nsubjpass signal,restored
R8201 T10145 T10144 acl caused,signal
R8202 T10146 T10145 agent by,caused
R8230 T10174 T10187 advmod Moreover,result
R8231 T10175 T10187 punct ",",result
R8232 T10176 T10177 det the,failure
R8233 T10177 T10187 nsubj failure,result
R8234 T10178 T10177 prep of,failure
R8235 T10179 T10180 compound S209A,RPS3
R8236 T10180 T10178 pobj RPS3,of
R8237 T10181 T10182 aux to,restore
R8238 T10182 T10177 acl restore,failure
R8239 T10183 T10184 compound luciferase,activity
R8240 T10184 T10182 dobj activity,restore
R8241 T10185 T10187 aux did,result
R8242 T10186 T10187 neg not,result
R8243 T10187 T10187 ROOT result,result
R8244 T10188 T10187 prep from,result
R8245 T10189 T10190 amod defective,translation
R8246 T10190 T10188 pobj translation,from
R8247 T10191 T10202 mark because,was
R8248 T10192 T10194 det the,overexpression
R8249 T10193 T10194 amod transient,overexpression
R8250 T10194 T10202 nsubj overexpression,was
R8251 T10195 T10194 prep of,overexpression
R8252 T10196 T10198 amod green,protein
R8253 T10197 T10198 amod fluorescent,protein
R8254 T10198 T10195 pobj protein,of
R8255 T10199 T10200 punct (,GFP
R8256 T10200 T10198 appos GFP,protein
R8257 T10201 T10198 punct ),protein
R8258 T10202 T10187 advcl was,result
R8259 T10203 T10202 acomp comparable,was
R8260 T10204 T10202 prep in,was
R8261 T10205 T10204 pobj cells,in
R8262 T10206 T10205 acl complemented,cells
R8263 T10207 T10206 prep with,complemented
R8264 T10208 T10207 pobj wild-type,with
R8265 T10209 T10208 cc or,wild-type
R8266 T10210 T10211 compound S029A,RPS3
R8267 T10211 T10208 conj RPS3,wild-type
R8268 T10212 T10214 punct (,Fig.
R8269 T10213 T10214 compound Supplementary,Fig.
R8270 T10214 T10211 appos Fig.,RPS3
R8271 T10215 T10214 nummod 8,Fig.
R8272 T10216 T10214 punct ),Fig.
R8348 T10292 T10295 nmod NFKBIA,promoters
R8349 T10293 T10292 cc and,NFKBIA
R8350 T10294 T10292 conj IL8,NFKBIA
R8351 T10295 T10290 pobj promoters,of
R8352 T10296 T10299 punct (,)
R8353 T10297 T10299 nmod Fig.,)
R8354 T10298 T10297 nummod 5e,Fig.
R8355 T10299 T10280 punct ),wild-type
R8356 T10300 T10272 punct .,stimulated
R8357 T10301 T10302 mark While,expressing
R8358 T10302 T10305 advcl expressing,had
R8359 T10303 T10304 compound RPS3,S209A
R8360 T10304 T10302 dobj S209A,expressing
R8361 T10305 T10315 advcl had,attenuated
R8362 T10306 T10307 det no,impact
R8363 T10307 T10305 dobj impact,had
R8364 T10308 T10307 prep on,impact
R8365 T10309 T10311 nummod p65,translocation
R8366 T10310 T10311 amod nuclear,translocation
R8367 T10311 T10308 pobj translocation,on
R8368 T10312 T10315 punct ",",attenuated
R8369 T10313 T10315 nsubj it,attenuated
R8370 T10314 T10315 advmod substantially,attenuated
R8371 T10315 T10315 ROOT attenuated,attenuated
R8372 T10316 T10317 nummod p65,recruitment
R8373 T10317 T10315 dobj recruitment,attenuated
R8374 T10318 T10319 punct (,Fig.
R8375 T10319 T10317 appos Fig.,recruitment
R8376 T10320 T10319 nummod 5e,Fig.
R8377 T10321 T10317 punct ),recruitment
R8378 T10322 T10315 punct .,attenuated
R8379 T10323 T10324 amod Additional,experiments
R8380 T10324 T10325 nsubj experiments,revealed
R8381 T10325 T10325 ROOT revealed,revealed
R8133 T10077 T10078 amod mutant,RPS3
R8134 T10078 T10072 pobj RPS3,with
R8135 T10079 T10078 prep via,RPS3
R8136 T10080 T10079 pobj transfection,via
R8137 T10081 T10046 punct .,silenced
R8138 T10082 T10083 mark As,expected
R8139 T10083 T10088 advcl expected,reduced
R8140 T10084 T10088 punct ",",reduced
R8141 T10085 T10086 compound RPS3,siRNA
R8142 T10086 T10088 nsubj siRNA,reduced
R8143 T10087 T10088 advmod severely,reduced
R8144 T10088 T10088 ROOT reduced,reduced
R8145 T10089 T10091 amod endogenous,abundance
R8146 T10090 T10091 compound RPS3,abundance
R8147 T10091 T10088 dobj abundance,reduced
R8148 T10092 T10088 prep compared,reduced
R8149 T10093 T10092 prep to,compared
R8150 T10094 T10095 compound NS,siRNA
R8151 T10095 T10093 pobj siRNA,to
R8152 T10096 T10088 punct ",",reduced
R8153 T10097 T10088 cc but,reduced
R8154 T10098 T10100 aux did,affect
R8155 T10099 T10100 neg not,affect
R8156 T10100 T10088 conj affect,reduced
R8157 T10101 T10103 det the,expression
R8158 T10102 T10103 amod robust,expression
R8159 T10103 T10100 dobj expression,affect
R8160 T10104 T10103 prep of,expression
R8161 T10105 T10106 amod Flag-tagged,RPS3
R8162 T10106 T10104 pobj RPS3,of
R8163 T10107 T10100 prep from,affect
R8164 T10108 T10110 det a,construct
R8165 T10109 T10110 amod transfected,construct
R8166 T10110 T10100 conj construct,affect
R8167 T10111 T10110 advcl lacking,construct
R8168 T10112 T10115 det the,UTR
R8169 T10113 T10114 nummod 3,′
R8170 T10114 T10115 compound ′,UTR
R8273 T10217 T10187 punct .,result
R8274 T10218 T10223 advcl Taken,suggest
R8275 T10219 T10218 advmod together,Taken
R8276 T10220 T10223 punct ",",suggest
R8277 T10221 T10222 det these,data
R8278 T10222 T10223 nsubj data,suggest
R8279 T10223 T10223 ROOT suggest,suggest
R8280 T10224 T10228 mark that,is
R8281 T10225 T10227 nummod RPS3,phosphorylation
R8282 T10226 T10227 nummod S209,phosphorylation
R8283 T10227 T10228 nsubj phosphorylation,is
R8284 T10228 T10223 ccomp is,suggest
R8285 T10229 T10228 acomp critical,is
R8286 T10230 T10229 prep for,critical
R8287 T10231 T10232 amod NF-κB,activity
R8288 T10232 T10230 pobj activity,for
R8289 T10233 T10232 acl involving,activity
R8290 T10234 T10238 det the,site
R8291 T10235 T10238 amod canonical,site
R8292 T10236 T10237 compound Ig,κB
R8293 T10237 T10238 compound κB,site
R8294 T10238 T10233 dobj site,involving
R8295 T10239 T10223 punct .,suggest
R8296 T10240 T10242 nsubj We,used
R8297 T10241 T10242 advmod next,used
R8298 T10242 T10242 ROOT used,used
R8299 T10243 T10244 compound chromatin,immunoprecipitation
R8300 T10244 T10242 dobj immunoprecipitation,used
R8301 T10245 T10246 aux to,determine
R8302 T10246 T10242 xcomp determine,used
R8303 T10247 T10250 mark whether,affects
R8304 T10248 T10249 compound S209,phosphorylation
R8305 T10249 T10250 nsubj phosphorylation,affects
R8306 T10250 T10246 ccomp affects,determine
R8307 T10251 T10250 dobj RPS3,affects
R8308 T10252 T10251 cc and,RPS3
R8309 T10253 T10254 nummod p65,recruitment
R8310 T10254 T10251 conj recruitment,RPS3
R8311 T10255 T10250 prep to,affects
R8312 T10256 T10258 amod specific,sites
R8313 T10257 T10258 compound κB,sites
R8314 T10258 T10255 pobj sites,to
R8315 T10259 T10258 prep in,sites
R8316 T10260 T10261 amod intact,chromatin
R8317 T10261 T10259 pobj chromatin,in
R8318 T10262 T10250 prep during,affects
R8319 T10263 T10264 compound NF-κB,activation
R8320 T10264 T10262 pobj activation,during
R8321 T10265 T10242 punct .,used
R8322 T10266 T10272 prep In,stimulated
R8323 T10267 T10269 nummod RPS3,cells
R8324 T10268 T10269 amod knockdown,cells
R8325 T10269 T10266 pobj cells,In
R8326 T10270 T10272 punct ",",stimulated
R8327 T10271 T10272 nsubj PMA+I,stimulated
R8328 T10272 T10272 ROOT stimulated,stimulated
R8329 T10273 T10274 det the,recruitment
R8330 T10274 T10272 dobj recruitment,stimulated
R8331 T10275 T10274 prep of,recruitment
R8332 T10276 T10277 advmod ectopically,expressed
R8333 T10277 T10280 amod expressed,wild-type
R8334 T10278 T10277 punct ",",expressed
R8335 T10279 T10280 compound Flag-tagged,wild-type
R8336 T10280 T10275 pobj wild-type,of
R8337 T10281 T10280 punct ",",wild-type
R8338 T10282 T10285 cc but,RPS3
R8339 T10283 T10285 neg not,RPS3
R8340 T10284 T10285 compound S209A,RPS3
R8341 T10285 T10280 conj RPS3,wild-type
R8342 T10286 T10280 prep to,wild-type
R8343 T10287 T10289 det the,sites
R8344 T10288 T10289 amod κB,sites
R8345 T10289 T10286 pobj sites,to
R8346 T10290 T10289 prep of,sites
R8347 T10291 T10292 det the,NFKBIA
R8423 T10367 T10365 appos Fig.,sites
R8424 T10368 T10367 nummod 5e,Fig.
R8425 T10369 T10365 punct ),sites
R8426 T10370 T10353 punct ",",was
R8427 T10371 T10353 advcl suggesting,was
R8428 T10372 T10373 det the,recruitment
R8429 T10373 T10374 nsubj recruitment,was
R8430 T10374 T10371 ccomp was,suggesting
R8431 T10375 T10376 advmod κB,site-specific
R8432 T10376 T10374 acomp site-specific,was
R8433 T10377 T10353 punct .,was
R8434 T10378 T10395 advmod Thus,depended
R8435 T10379 T10395 punct ",",depended
R8436 T10380 T10381 det the,recruitment
R8437 T10381 T10395 nsubj recruitment,depended
R8438 T10382 T10381 prep of,recruitment
R8439 T10383 T10382 pobj RPS3,of
R8440 T10384 T10386 advmod as,as
R8441 T10385 T10386 advmod well,as
R8442 T10386 T10381 cc as,recruitment
R8443 T10387 T10389 det the,recruitment
R8444 T10388 T10389 amod contingent,recruitment
R8445 T10389 T10381 conj recruitment,recruitment
R8446 T10390 T10389 prep of,recruitment
R8447 T10391 T10390 pobj p65,of
R8448 T10392 T10389 prep to,recruitment
R8449 T10393 T10394 amod key,promoters
R8450 T10394 T10392 pobj promoters,to
R8451 T10395 T10395 ROOT depended,depended
R8452 T10396 T10395 prep on,depended
R8453 T10397 T10396 pobj S209,on
R8454 T10398 T10395 punct .,depended
R8455 T10399 T10399 ROOT Interleukin,Interleukin
R8456 T10400 T10399 nummod 8,Interleukin
R8457 T10401 T10404 punct (,secretion
R8458 T10402 T10404 nmod IL-8,secretion
R8459 T10403 T10404 punct ),secretion
R8460 T10404 T10415 nmod secretion,stimulation
R8461 T10405 T10404 acl induced,secretion
R8462 T10406 T10405 agent by,induced
R8463 T10407 T10410 det either,receptor
R8464 T10408 T10410 compound T,receptor
R8465 T10409 T10410 compound cell,receptor
R8466 T10410 T10406 pobj receptor,by
R8467 T10411 T10412 punct (,TCR
R8382 T10326 T10339 mark that,increased
R8383 T10327 T10328 nummod p65,attraction
R8384 T10328 T10339 nsubjpass attraction,increased
R8385 T10329 T10328 prep to,attraction
R8386 T10330 T10334 amod RPS3-independent,promoters
R8387 T10331 T10333 amod NF-κB,gene
R8388 T10332 T10333 compound target,gene
R8389 T10333 T10334 compound gene,promoters
R8390 T10334 T10329 pobj promoters,to
R8391 T10335 T10336 amod such,as
R8392 T10336 T10334 prep as,promoters
R8393 T10337 T10336 pobj CD25,as
R8394 T10338 T10339 auxpass was,increased
R8395 T10339 T10325 ccomp increased,revealed
R8396 T10340 T10339 punct (,increased
R8397 T10341 T10342 compound Supplementary,Fig.
R8398 T10342 T10339 npadvmod Fig.,increased
R8399 T10343 T10342 nummod 9,Fig.
R8400 T10344 T10339 punct ),increased
R8401 T10345 T10339 punct ",",increased
R8402 T10346 T10339 advcl consistent,increased
R8403 T10347 T10346 prep with,consistent
R8404 T10348 T10350 poss our,observations6
R8405 T10349 T10350 amod previous,observations6
R8406 T10350 T10347 pobj observations6,with
R8407 T10351 T10325 punct .,revealed
R8408 T10352 T10353 expl There,was
R8409 T10353 T10353 ROOT was,was
R8410 T10354 T10356 det no,Flag-RPS3
R8411 T10355 T10356 amod significant,Flag-RPS3
R8412 T10356 T10353 attr Flag-RPS3,was
R8413 T10357 T10356 cc or,Flag-RPS3
R8414 T10358 T10359 nummod p65,recruitment
R8415 T10359 T10356 conj recruitment,Flag-RPS3
R8416 T10360 T10359 prep to,recruitment
R8417 T10361 T10362 compound ACTB,promoter
R8418 T10362 T10360 pobj promoter,to
R8419 T10363 T10359 acl lacking,recruitment
R8420 T10364 T10365 compound κB,sites
R8421 T10365 T10363 dobj sites,lacking
R8422 T10366 T10365 punct (,sites
R10014 T12437 T12438 nummod NleH1,inhibits
R10015 T12438 T12445 nsubj inhibits,are
R10016 T12439 T12440 compound RPS3,phosphorylation
R10017 T12440 T12438 dobj phosphorylation,inhibits
R10018 T12441 T12438 prep in,inhibits
R10019 T12442 T12444 amod vitro,pathogens
R10020 T12443 T12444 compound EHEC,pathogens
R10021 T12444 T12441 pobj pathogens,in
R10022 T12445 T12445 ROOT are,are
R10023 T12446 T12448 amod important,agents
R10024 T12447 T12448 amod causative,agents
R10025 T12448 T12445 attr agents,are
R10026 T12449 T12448 prep of,agents
R10027 T12450 T12452 det both,disease
R10028 T12451 T12452 amod foodborne,disease
R10029 T12452 T12449 pobj disease,of
R10030 T12453 T12452 cc and,disease
R10031 T12454 T12456 amod pediatric,failure31
R10032 T12455 T12456 amod renal,failure31
R10033 T12456 T12452 conj failure31,disease
R10034 T12457 T12445 punct .,are
R10035 T12458 T12459 nsubj EHEC,utilize
R10036 T12459 T12459 ROOT utilize,utilize
R10037 T12460 T12459 dobj T3SS,utilize
R10038 T12461 T12462 aux to,inject
R10039 T12462 T12459 xcomp inject,utilize
R10040 T12463 T12464 compound effector,proteins
R10041 T12464 T12462 dobj proteins,inject
R10042 T12465 T12466 advmod directly,into
R10043 T12466 T12462 prep into,inject
R10044 T12467 T12469 amod intestinal,cells32
R10045 T12468 T12469 amod epithelial,cells32
R10046 T12469 T12466 pobj cells32,into
R10047 T12470 T12475 punct ",",inhibit
R10048 T12471 T12472 det a,subset
R10049 T12472 T12475 nsubj subset,inhibit
R10050 T12473 T12472 prep of,subset
R10051 T12474 T12473 pobj which,of
R10052 T12475 T12459 conj inhibit,utilize
R10053 T12476 T12477 advmod NF-κB-dependent,innate
R10054 T12477 T12480 amod innate,33-38
R10055 T12478 T12477 appos responses9,innate
R10056 T12479 T12477 punct ",",innate
R10057 T12480 T12475 dobj 33-38,inhibit
R10058 T12481 T12475 punct .,inhibit
R10059 T12482 T12485 det The,O157
R10060 T12483 T12485 compound E.,O157
R10061 T12484 T12485 compound coli,O157
R10062 T12485 T12485 ROOT O157,O157
R10063 T12486 T12485 punct :,O157
R10064 T12487 T12490 compound H7,protein
R10065 T12488 T12490 compound EDL933,protein
R10066 T12489 T12490 compound effector,protein
R10067 T12490 T12492 nsubj protein,binds
R10068 T12491 T12492 nsubj NleH1,binds
R10069 T12492 T12492 ROOT binds,binds
R10070 T12493 T12492 prep to,binds
R10071 T12494 T12492 cc and,binds
R10072 T12495 T12492 conj attenuates,binds
R8468 T10412 T10410 appos TCR,receptor
R8469 T10413 T10405 punct ),induced
R8470 T10414 T10415 amod agonist,stimulation
R8471 T10415 T10419 nsubjpass stimulation,decreased
R8472 T10416 T10415 cc or,stimulation
R8473 T10417 T10415 conj PMA+I,stimulation
R8474 T10418 T10419 auxpass was,decreased
R8475 T10419 T10419 ROOT decreased,decreased
R8476 T10420 T10419 prep as,decreased
R8477 T10421 T10422 det a,consequence
R8478 T10422 T10420 pobj consequence,as
R8479 T10423 T10422 prep of,consequence
R8480 T10424 T10425 amod reduced,RPS3/p65
R8481 T10425 T10426 compound RPS3/p65,recruitment
R8482 T10426 T10423 pobj recruitment,of
R8483 T10427 T10422 prep to,consequence
R8484 T10428 T10431 det the,sites
R8485 T10429 T10430 compound IL8,κB
R8486 T10430 T10431 compound κB,sites
R8487 T10431 T10427 pobj sites,to
R8488 T10432 T10431 prep in,sites
R8489 T10433 T10434 det the,presence
R8490 T10434 T10432 pobj presence,in
R8491 T10435 T10434 prep of,presence
R8492 T10436 T10438 nummod S209A,compared
R8493 T10437 T10438 amod mutant,compared
R8494 T10438 T10419 prep compared,decreased
R8495 T10439 T10438 prep to,compared
R8496 T10440 T10441 compound wild-type,RPS3
R8497 T10441 T10439 pobj RPS3,to
R8498 T10442 T10444 punct (,Fig.
R8499 T10443 T10444 compound Supplementary,Fig.
R8500 T10444 T10441 appos Fig.,RPS3
R8501 T10445 T10444 nummod 10,Fig.
R8502 T10446 T10444 punct ),Fig.
R8503 T10447 T10419 punct .,decreased
R8504 T10448 T10454 advmod However,was
R8505 T10449 T10454 punct ",",was
R8506 T10450 T10451 compound cell,surface
R8507 T10451 T10453 compound surface,expression
R8508 T10452 T10453 compound CD25,expression
R8509 T10453 T10454 nsubj expression,was
R8510 T10454 T10454 ROOT was,was
R8511 T10455 T10454 acomp comparable,was
R8512 T10456 T10455 prep between,comparable
R8513 T10457 T10458 det the,wild-type
R8514 T10458 T10456 pobj wild-type,between
R8515 T10459 T10458 cc and,wild-type
R8516 T10460 T10461 compound S209A,RPS3
R8517 T10461 T10458 conj RPS3,wild-type
R8518 T10462 T10463 amod transfected,cells
R8519 T10463 T10456 pobj cells,between
R8520 T10464 T10466 punct (,Fig.
R8521 T10465 T10466 compound Supplementary,Fig.
R8522 T10466 T10454 attr Fig.,was
R8523 T10467 T10466 nummod 11,Fig.
R8524 T10468 T10466 punct ),Fig.
R8525 T10469 T10454 punct .,was
R8526 T10470 T10479 advmod Therefore,required
R8527 T10471 T10479 punct ",",required
R8528 T10472 T10474 compound RPS3,phosphorylation
R8529 T10473 T10474 compound S209,phosphorylation
R8530 T10474 T10479 nsubjpass phosphorylation,required
R8531 T10475 T10474 prep by,phosphorylation
R8532 T10476 T10475 pobj IKKβ,by
R8533 T10477 T10479 auxpass is,required
R8534 T10478 T10479 advmod apparently,required
R8535 T10479 T10479 ROOT required,required
R8536 T10480 T10479 prep for,required
R8537 T10481 T10480 pobj RPS3,for
R8538 T10482 T10479 prep in,required
R8539 T10483 T10482 pcomp directing,in
R8540 T10484 T10483 dobj NF-κB,directing
R8541 T10485 T10483 prep to,directing
R8542 T10486 T10488 det a,subset
R8543 T10487 T10488 amod specific,subset
R8544 T10488 T10485 pobj subset,to
R8545 T10489 T10488 prep of,subset
R8546 T10490 T10491 compound target,genes
R8547 T10491 T10489 pobj genes,of
R8548 T10492 T10479 punct .,required
R10076 T12499 T12492 punct ",",binds
R10077 T12500 T12501 advmod thus,impairing
R10078 T12501 T12492 advcl impairing,binds
R10079 T12502 T12503 compound RPS3-dependent,NF-κB
R10080 T12503 T12504 compound NF-κB,signaling9
R10081 T12504 T12501 dobj signaling9,impairing
R10082 T12505 T12492 punct .,binds
R10083 T12506 T12508 nsubj We,hypothesized
R10084 T12507 T12508 advmod therefore,hypothesized
R10085 T12508 T12508 ROOT hypothesized,hypothesized
R10086 T12509 T12512 mark that,function
R10087 T12510 T12512 nsubj NleH1,function
R10088 T12511 T12512 aux may,function
R10089 T12512 T12508 ccomp function,hypothesized
R10090 T12513 T12512 prep by,function
R10091 T12514 T12513 pcomp inhibiting,by
R10092 T12515 T12517 compound RPS3,phosphorylation
R10093 T12516 T12517 compound S209,phosphorylation
R10094 T12517 T12514 dobj phosphorylation,inhibiting
R10095 T12518 T12508 punct .,hypothesized
R10096 T12519 T12520 mark As,expected
R10097 T12520 T12520 ROOT expected,expected
R10098 T12521 T12520 punct ",",expected
R10099 T12522 T12520 advcl transfecting,expected
R10100 T12523 T12524 amod increasing,amounts
R10101 T12524 T12522 dobj amounts,transfecting
R10102 T12525 T12524 prep of,amounts
R10103 T12526 T12527 amod NleH1-HA,plasmid
R10104 T12527 T12525 pobj plasmid,of
R10105 T12528 T12524 acl blocked,amounts
R10106 T12529 T12531 amod TNFα-induced,activation
R10107 T12530 T12531 compound NF-κB,activation
R10108 T12531 T12528 dobj activation,blocked
R10109 T12532 T12528 prep in,blocked
R10110 T12533 T12535 det a,manner
R10111 T12534 T12535 amod dose-dependent,manner
R10112 T12535 T12532 pobj manner,in
R10113 T12536 T12538 punct (,6a-b
R10114 T12537 T12538 compound Fig.,6a-b
R10115 T12538 T12535 appos 6a-b,manner
R10116 T12539 T12540 punct ),9
R10117 T12540 T12538 advmod 9,6a-b
R10118 T12541 T12520 punct .,expected
R10119 T12542 T12545 advmod Remarkably,reduced
R10120 T12543 T12545 punct ",",reduced
R10121 T12544 T12545 nsubj NleH1,reduced
R10122 T12545 T12545 ROOT reduced,reduced
R10123 T12546 T12554 det both,phosphorylation
R10124 T12547 T12554 amod TNF-induced,phosphorylation
R10125 T12548 T12547 punct ",",TNF-induced
R10126 T12549 T12551 advmod as,as
R10127 T12550 T12551 advmod well,as
R10128 T12551 T12547 cc as,TNF-induced
R10129 T12552 T12553 amod basal,RPS3
R10130 T12553 T12547 conj RPS3,TNF-induced
R10131 T12554 T12545 dobj phosphorylation,reduced
R10132 T12555 T12545 prep to,reduced
R10133 T12556 T12557 advmod roughly,20
R10134 T12557 T12558 nummod 20,%
R10135 T12558 T12555 pobj %,to
R10136 T12559 T12558 prep of,%
R10137 T12560 T12561 compound vehicle,control
R10138 T12561 T12559 pobj control,of
R10139 T12562 T12545 punct (,reduced
R10140 T12563 T12565 nmod Fig.,)
R10141 T12564 T12563 nummod 6c,Fig.
R10142 T12565 T12545 punct ),reduced
R10143 T12566 T12545 punct .,reduced
R10144 T12567 T12571 csubj Expressing,interfere
R10145 T12568 T12567 dobj NleH1,Expressing
R10146 T12569 T12571 aux does,interfere
R10147 T12570 T12571 neg not,interfere
R10148 T12571 T12571 ROOT interfere,interfere
R10149 T12572 T12571 prep with,interfere
R10150 T12573 T12576 det either,activation
R10151 T12574 T12576 amod TNF-induced,activation
R10152 T12575 T12576 compound IKK,activation
R10073 T12496 T12498 nmod RPS3,translocation
R10074 T12497 T12498 amod nuclear,translocation
R10075 T12498 T12495 dobj translocation,attenuates
R10226 T12649 T12652 det a,increase
R10227 T12650 T12652 amod ∼,increase
R10228 T12651 T12652 amod 7-fold,increase
R10229 T12652 T12648 dobj increase,stimulated
R10230 T12653 T12652 prep in,increase
R10231 T12654 T12656 compound RPS3,phosphorylation
R10232 T12655 T12656 compound S209,phosphorylation
R10233 T12656 T12653 pobj phosphorylation,in
R10234 T12657 T12648 punct ",",stimulated
R10235 T12658 T12648 advcl peaking,stimulated
R10236 T12659 T12658 prep at,peaking
R10237 T12660 T12661 nummod 30,minutes
R10238 T12661 T12659 pobj minutes,at
R10239 T12662 T12661 punct (,minutes
R10240 T12663 T12661 appos Fig.,minutes
R10241 T12664 T12663 nummod 6d,Fig.
R10242 T12665 T12661 punct ),minutes
R10243 T12666 T12648 punct .,stimulated
R10244 T12667 T12675 prep By,impaired
R10245 T12668 T12667 pobj contrast,By
R10246 T12669 T12675 punct ",",impaired
R10247 T12670 T12672 compound RPS3,phosphorylation
R10248 T12671 T12672 compound S209,phosphorylation
R10249 T12672 T12675 nsubjpass phosphorylation,impaired
R10250 T12673 T12675 auxpass was,impaired
R10251 T12674 T12675 advmod substantially,impaired
R10252 T12675 T12675 ROOT impaired,impaired
R10253 T12676 T12675 prep in,impaired
R10254 T12677 T12676 pobj cells,in
R10255 T12678 T12677 acl infected,cells
R10256 T12679 T12678 prep with,infected
R10257 T12680 T12683 amod wild-type,O157
R10258 T12681 T12683 compound E.,O157
R10259 T12682 T12683 compound coli,O157
R10260 T12683 T12679 pobj O157,with
R10261 T12684 T12675 punct :,impaired
R10262 T12685 T12685 ROOT H7,H7
R10263 T12686 T12687 punct (,Fig.
R10264 T12687 T12685 appos Fig.,H7
R10265 T12688 T12687 nummod 6d,Fig.
R10266 T12689 T12685 punct ),H7
R10267 T12690 T12685 punct .,H7
R10268 T12691 T12698 advmod However,unimpaired
R10269 T12692 T12698 punct ",",unimpaired
R10270 T12693 T12696 amod TNF-induced,phosphorylation
R10271 T12694 T12696 compound RPS3,phosphorylation
R10272 T12695 T12696 compound S209,phosphorylation
R10273 T12696 T12698 nsubjpass phosphorylation,unimpaired
R10274 T12697 T12698 auxpass was,unimpaired
R10275 T12698 T12698 ROOT unimpaired,unimpaired
R10276 T12699 T12698 prep in,unimpaired
R10277 T12700 T12699 pobj cells,in
R10278 T12701 T12700 acl infected,cells
R10279 T12702 T12701 prep with,infected
R10280 T12703 T12704 det either,ΔnleH1
R10281 T12704 T12702 pobj ΔnleH1,with
R10282 T12705 T12704 cc or,ΔnleH1
R10283 T12706 T12704 conj ΔescN,ΔnleH1
R10284 T12707 T12706 punct (,ΔescN
R10285 T12708 T12706 appos Fig.,ΔescN
R10286 T12709 T12708 nummod 6d,Fig.
R10287 T12710 T12706 punct ),ΔescN
R10288 T12711 T12698 punct .,unimpaired
R10289 T12712 T12713 nsubj We,showed
R10290 T12713 T12713 ROOT showed,showed
R10291 T12714 T12713 advmod previously,showed
R10292 T12715 T12716 mark that,wild-type
R10293 T12716 T12713 ccomp wild-type,showed
R10294 T12717 T12716 punct ",",wild-type
R10295 T12718 T12716 cc but,wild-type
R10296 T12719 T12720 neg not,ΔnleH1
R10297 T12720 T12716 conj ΔnleH1,wild-type
R10298 T12721 T12720 cc or,ΔnleH1
R10299 T12722 T12725 compound ΔescN,O157
R10300 T12723 T12725 compound E.,O157
R10376 T12799 T12800 det these,genes
R10377 T12800 T12801 nsubj genes,were
R10378 T12801 T12801 ROOT were,were
R10379 T12802 T12803 advmod only,modestly
R10380 T12803 T12804 advmod modestly,upregulated
R10381 T12804 T12801 acomp upregulated,were
R10382 T12805 T12804 prep in,upregulated
R10383 T12806 T12805 pobj cells,in
R10384 T12807 T12806 acl infected,cells
R10385 T12808 T12807 prep with,infected
R10386 T12809 T12811 compound wild-type,coli
R10387 T12810 T12811 compound E.,coli
R10388 T12811 T12808 pobj coli,with
R10389 T12812 T12812 ROOT O157,O157
R10390 T12813 T12812 punct :,O157
R10391 T12814 T12818 nsubj H7,induced
R10392 T12815 T12814 punct ",",H7
R10393 T12816 T12814 cc but,H7
R10394 T12817 T12818 advmod significantly,induced
R10395 T12818 T12818 ROOT induced,induced
R10396 T12819 T12818 prep in,induced
R10153 T12576 T12572 pobj activation,with
R10154 T12577 T12576 cc or,activation
R10155 T12578 T12576 conj IκBα,activation
R10156 T12579 T12576 conj degradation,activation
R10157 T12580 T12576 punct ",",activation
R10158 T12581 T12576 amod consistent,activation
R10159 T12582 T12581 prep with,consistent
R10160 T12583 T12584 det the,lack
R10161 T12584 T12582 pobj lack,with
R10162 T12585 T12584 prep of,lack
R10163 T12586 T12587 amod NleH1,impact
R10164 T12587 T12585 pobj impact,of
R10165 T12588 T12587 prep on,impact
R10166 T12589 T12591 nummod p65,translocation9
R10167 T12590 T12591 amod nuclear,translocation9
R10168 T12591 T12588 pobj translocation9,on
R10169 T12592 T12584 punct (,lack
R10170 T12593 T12584 appos Fig.,lack
R10171 T12594 T12593 nummod 6c,Fig.
R10172 T12595 T12584 punct ),lack
R10173 T12596 T12571 punct .,interfere
R10174 T12597 T12598 aux To,determine
R10175 T12598 T12606 advcl determine,infected
R10176 T12599 T12601 mark if,inhibits
R10177 T12600 T12601 nsubj NleH1,inhibits
R10178 T12601 T12606 advcl inhibits,infected
R10179 T12602 T12603 compound RPS3,phosphorylation
R10180 T12603 T12601 dobj phosphorylation,inhibits
R10181 T12604 T12606 punct ",",infected
R10182 T12605 T12606 nsubj we,infected
R10183 T12606 T12606 ROOT infected,infected
R10184 T12607 T12608 compound HeLa,cells
R10185 T12608 T12606 dobj cells,infected
R10186 T12609 T12606 prep with,infected
R10187 T12610 T12612 compound E.,O157
R10188 T12611 T12612 compound coli,O157
R10189 T12612 T12609 pobj O157,with
R10190 T12613 T12612 punct :,O157
R10191 T12614 T12615 compound H7,strains
R10192 T12615 T12612 appos strains,O157
R10193 T12616 T12615 acl possessing,strains
R10194 T12617 T12616 cc or,possessing
R10195 T12618 T12616 conj lacking,possessing
R10196 T12619 T12620 preconj either,nleH1
R10197 T12620 T12618 dobj nleH1,lacking
R10198 T12621 T12622 punct (,ΔnleH1
R10199 T12622 T12620 appos ΔnleH1,nleH1
R10200 T12623 T12622 punct ),ΔnleH1
R10201 T12624 T12620 cc or,nleH1
R10202 T12625 T12620 conj with,nleH1
R10203 T12626 T12627 det a,strain
R10204 T12627 T12625 pobj strain,with
R10205 T12628 T12627 acl lacking,strain
R10206 T12629 T12630 det a,functional
R10207 T12630 T12628 dobj functional,lacking
R10208 T12631 T12632 nummod T3SS,unable
R10209 T12632 T12630 amod unable,functional
R10210 T12633 T12634 aux to,inject
R10211 T12634 T12632 xcomp inject,unable
R10212 T12635 T12634 dobj NleH1,inject
R10213 T12636 T12634 prep into,inject
R10214 T12637 T12638 amod mammalian,cells
R10215 T12638 T12636 pobj cells,into
R10216 T12639 T12640 punct (,ΔescN
R10217 T12640 T12638 appos ΔescN,cells
R10218 T12641 T12630 punct ),functional
R10219 T12642 T12606 punct .,infected
R10220 T12643 T12648 prep In,stimulated
R10221 T12644 T12645 amod uninfected,cells
R10222 T12645 T12643 pobj cells,In
R10223 T12646 T12648 punct ",",stimulated
R10224 T12647 T12648 nsubj TNF-treatment,stimulated
R10225 T12648 T12648 ROOT stimulated,stimulated
R10301 T12724 T12725 compound coli,O157
R10302 T12725 T12720 conj O157,ΔnleH1
R10303 T12726 T12725 punct :,O157
R10304 T12727 T12729 nsubj H7,attenuated
R10305 T12728 T12729 advmod significantly,attenuated
R10306 T12729 T12729 ROOT attenuated,attenuated
R10307 T12730 T12733 amod TNF-induced,translocation9
R10308 T12731 T12733 amod RPS3,translocation9
R10309 T12732 T12733 amod nuclear,translocation9
R10310 T12733 T12729 dobj translocation9,attenuated
R10311 T12734 T12729 punct .,attenuated
R10312 T12735 T12736 det The,parallel
R10313 T12736 T12748 nsubj parallel,provides
R10314 T12737 T12736 prep between,parallel
R10315 T12738 T12739 nummod RPS3,phosphorylation
R10316 T12739 T12737 pobj phosphorylation,between
R10317 T12740 T12739 cc and,phosphorylation
R10318 T12741 T12743 poss its,translocation
R10319 T12742 T12743 amod nuclear,translocation
R10320 T12743 T12739 conj translocation,phosphorylation
R10321 T12744 T12743 prep during,translocation
R10322 T12745 T12746 compound E.,coli
R10323 T12746 T12747 compound coli,infection
R10324 T12747 T12744 pobj infection,during
R10325 T12748 T12748 ROOT provides,provides
R10326 T12749 T12748 dobj evidence,provides
R10327 T12750 T12748 prep in,provides
R10328 T12751 T12752 det the,context
R10329 T12752 T12750 pobj context,in
R10330 T12753 T12752 prep of,context
R10331 T12754 T12757 det an,process
R10332 T12755 T12757 amod NF-κB-dependent,process
R10333 T12756 T12757 compound disease,process
R10334 T12757 T12753 pobj process,of
R10335 T12758 T12762 mark that,is
R10336 T12759 T12761 compound RPS3,phosphorylation
R10337 T12760 T12761 compound S209,phosphorylation
R10338 T12761 T12762 nsubj phosphorylation,is
R10339 T12762 T12748 advcl is,provides
R10340 T12763 T12762 acomp important,is
R10341 T12764 T12763 prep for,important
R10342 T12765 T12766 amod nuclear,translocation
R10343 T12766 T12764 pobj translocation,for
R10344 T12767 T12748 punct .,provides
R10345 T12768 T12769 poss Our,discovery
R10346 T12769 T12776 nsubj discovery,suggested
R10347 T12770 T12772 mark that,inhibits
R10348 T12771 T12772 nsubj NleH1,inhibits
R10349 T12772 T12769 acl inhibits,discovery
R10350 T12773 T12775 compound RPS3,phosphorylation
R10351 T12774 T12775 compound S209,phosphorylation
R10352 T12775 T12776 nsubj phosphorylation,suggested
R10353 T12776 T12776 ROOT suggested,suggested
R10354 T12777 T12781 mark that,blocks
R10355 T12778 T12781 nsubj it,blocks
R10356 T12779 T12781 aux should,blocks
R10357 T12780 T12781 advmod also,blocks
R10358 T12781 T12776 ccomp blocks,suggested
R10359 T12782 T12786 nmod RPS3-dependent,transcription
R10360 T12783 T12786 compound NF-κB,transcription
R10361 T12784 T12786 compound target,transcription
R10362 T12785 T12786 compound gene,transcription
R10363 T12786 T12781 dobj transcription,blocks
R10364 T12787 T12789 punct (,IL8
R10365 T12788 T12789 nmod e.g.,IL8
R10366 T12789 T12791 nmod IL8,NFKBIA
R10367 T12790 T12791 punct ",",NFKBIA
R10368 T12791 T12781 conj NFKBIA,blocks
R10369 T12792 T12791 punct ",",NFKBIA
R10370 T12793 T12791 cc and,NFKBIA
R10371 T12794 T12791 conj TNFAIP3,NFKBIA
R10372 T12795 T12791 punct ),NFKBIA
R10373 T12796 T12776 punct .,suggested
R10374 T12797 T12801 advmod Indeed,were
R10375 T12798 T12801 punct ",",were
R10452 T12875 T12872 dobj phosphorylation,blocking
R10453 T12876 T12872 cc and,blocking
R10454 T12877 T12878 advmod thereby,impairing
R10455 T12878 T12872 conj impairing,blocking
R10456 T12879 T12883 amod critical,genes
R10457 T12880 T12883 amod RPS3-dependent,genes
R10458 T12881 T12883 compound NF-κB,genes
R10459 T12882 T12883 compound target,genes
R10460 T12883 T12878 dobj genes,impairing
R10461 T12884 T12861 punct .,demonstrate
R10397 T12820 T12819 pobj cells,in
R10398 T12821 T12820 acl infected,cells
R10399 T12822 T12821 prep with,infected
R10400 T12823 T12824 det either,ΔnleH1
R10401 T12824 T12827 nmod ΔnleH1,strains
R10402 T12825 T12824 cc or,ΔnleH1
R10403 T12826 T12824 conj ΔescN,ΔnleH1
R10404 T12827 T12822 pobj strains,with
R10405 T12828 T12818 punct (,induced
R10406 T12829 T12818 dobj Fig.,induced
R10407 T12830 T12829 nummod 6e,Fig.
R10408 T12831 T12829 punct ),Fig.
R10409 T12832 T12818 punct .,induced
R10410 T12833 T12838 prep In,had
R10411 T12834 T12833 pobj contrast,In
R10412 T12835 T12838 punct ",",had
R10413 T12836 T12838 advcl deleting,had
R10414 T12837 T12838 nsubj nleH1,had
R10415 T12838 T12838 ROOT had,had
R10416 T12839 T12840 det no,impact
R10417 T12840 T12838 dobj impact,had
R10418 T12841 T12840 prep on,impact
R10419 T12842 T12843 det the,expression
R10420 T12843 T12841 pobj expression,on
R10421 T12844 T12843 prep of,expression
R10423 T12846 T12844 pobj genes,of
R10424 T12847 T12846 punct ",",genes
R10425 T12848 T12846 prep including,genes
R10426 T12849 T12848 pobj CD25,including
R10427 T12850 T12849 cc and,CD25
R10428 T12851 T12849 conj TNFSF13B,CD25
R10429 T12852 T12851 punct (,TNFSF13B
R10430 T12853 T12854 compound Supplementary,Fig.
R10431 T12854 T12849 conj Fig.,CD25
R10432 T12855 T12854 nummod 12,Fig.
R10433 T12856 T12838 punct ),had
R10434 T12857 T12838 punct .,had
R10435 T12858 T12861 advmod Together,demonstrate
R10436 T12859 T12860 det these,results
R10437 T12860 T12861 nsubj results,demonstrate
R10438 T12861 T12861 ROOT demonstrate,demonstrate
R10439 T12862 T12865 mark that,inhibits
R10440 T12863 T12865 nsubj NleH1,inhibits
R10441 T12864 T12865 advmod specifically,inhibits
R10442 T12865 T12861 ccomp inhibits,demonstrate
R10443 T12866 T12869 det the,response
R10444 T12867 T12869 amod protective,response
R10445 T12868 T12869 amod immune,response
R10446 T12869 T12865 dobj response,inhibits
R10447 T12870 T12865 prep by,inhibits
R10448 T12871 T12872 advmod directly,blocking
R10449 T12872 T12870 pcomp blocking,by
R10450 T12873 T12875 compound RPS3,phosphorylation
R10451 T12874 T12875 compound S209,phosphorylation
R11306 T14046 T14047 compound piglet,colons
R11307 T14047 T14045 dobj colons,isolated
R11308 T14048 T14045 prep at,isolated
R11309 T14049 T14048 pobj necropsy,at
R11310 T14050 T14045 punct ",",isolated
R11311 T14051 T14045 cc and,isolated
R11312 T14052 T14045 conj subjected,isolated
R11313 T14053 T14052 dobj them,subjected
R11314 T14054 T14055 aux to,immunohistochemistry
R11315 T14055 T14052 advcl immunohistochemistry,subjected
R11316 T14056 T14052 advcl using,subjected
R11317 T14057 T14059 poss our,antibody
R11318 T14058 T14059 amod phospho-RPS3,antibody
R11319 T14059 T14056 dobj antibody,using
R11320 T14060 T14045 punct .,isolated
R11321 T14061 T14076 advmod Consistent,exhibited
R11322 T14062 T14061 prep with,Consistent
R11323 T14063 T14076 prep in,exhibited
R11324 T14064 T14065 amod vitro,data
R11325 T14065 T14063 pobj data,in
R11326 T14066 T14076 punct ",",exhibited
R11327 T14067 T14076 nsubj piglets,exhibited
R11328 T14068 T14067 acl infected,piglets
R11329 T14069 T14068 prep with,infected
R11330 T14070 T14073 amod wild-type,O157
R11331 T14071 T14073 compound E.,O157
R11332 T14072 T14073 compound coli,O157
R11333 T14073 T14069 pobj O157,with
R11334 T14074 T14076 punct :,exhibited
R11335 T14075 T14076 nsubj H7,exhibited
R11336 T14076 T14076 ROOT exhibited,exhibited
R11337 T14077 T14076 dobj diffuse,exhibited
R11338 T14078 T14077 cc and,diffuse
R11339 T14079 T14080 amod low,intensity
R11340 T14080 T14082 nmod intensity,staining
R11341 T14081 T14082 compound phospho-RPS3,staining
R11342 T14082 T14077 conj staining,diffuse
R11343 T14083 T14076 punct ",",exhibited
R11344 T14084 T14094 mark whereas,was
R11345 T14085 T14094 prep in,was
R11346 T14086 T14085 pobj piglets,in
R11347 T14087 T14086 acl infected,piglets
R11348 T14088 T14087 prep with,infected
R11349 T14089 T14093 amod ΔnleH1,expression
R11350 T14090 T14093 amod mutant,expression
R11351 T14091 T14093 punct ",",expression
R11352 T14092 T14093 amod phospho-RPS3,expression
R11353 T14093 T14088 pobj expression,with
R11354 T14094 T14076 advcl was,exhibited
R11355 T14095 T14094 acomp florid,was
R11209 T13949 T13950 nsubj NleH1,inhibits
R11210 T13950 T13950 ROOT inhibits,inhibits
R11211 T13951 T13953 compound RPS3,phosphorylation
R11212 T13952 T13953 compound S209,phosphorylation
R11213 T13953 T13950 dobj phosphorylation,inhibits
R11214 T13954 T13950 prep in,inhibits
R11215 T13955 T13954 pobj vivo,in
R11216 T13956 T13958 nsubj We,utilized
R11217 T13957 T13958 advmod previously,utilized
R11218 T13958 T13950 ccomp utilized,inhibits
R11219 T13959 T13963 det a,model
R11220 T13960 T13963 amod gnotobiotic,model
R11221 T13961 T13963 amod piglet,model
R11222 T13962 T13963 compound infection,model
R11223 T13963 T13958 dobj model,utilized
R11224 T13964 T13965 aux to,determine
R11225 T13965 T13963 relcl determine,model
R11226 T13966 T13972 mark that,died
R11227 T13967 T13972 nsubj piglets,died
R11228 T13968 T13967 acl infected,piglets
R11229 T13969 T13968 prep with,infected
R11230 T13970 T13971 amod ΔnleH1,mutant
R11231 T13971 T13972 nsubj mutant,died
R11232 T13972 T13965 ccomp died,determine
R11233 T13973 T13974 advmod more,rapidly
R11234 T13974 T13972 advmod rapidly,died
R11235 T13975 T13974 prep than,rapidly
R11236 T13976 T13975 pobj those,than
R11237 T13977 T13976 acl infected,those
R11238 T13978 T13977 prep with,infected
R11239 T13979 T13982 amod wild-type,O157
R11240 T13980 T13982 compound E.,O157
R11241 T13981 T13982 compound coli,O157
R11242 T13982 T13978 pobj O157,with
R11243 T13983 T13972 punct :,died
R11244 T13984 T13972 intj H7,died
R11245 T13985 T13950 punct .,inhibits
R11246 T13986 T13990 nsubj Piglets,displayed
R11247 T13987 T13986 acl infected,Piglets
R11248 T13988 T13987 prep with,infected
R11249 T13989 T13988 pobj ΔnleH1,with
R11250 T13990 T13990 ROOT displayed,displayed
R11251 T13991 T13992 amod clinical,disease
R11252 T13992 T13990 dobj disease,displayed
R11253 T13993 T13992 amod consistent,disease
R11254 T13994 T13993 prep with,consistent
R11255 T13995 T13998 det a,response
R11256 T13996 T13998 amod robust,response
R11257 T13997 T13998 amod inflammatory,response
R11258 T13998 T13994 pobj response,with
R11259 T13999 T13990 punct ",",displayed
R11260 T14000 T13990 cc but,displayed
R11261 T14001 T13990 conj with,displayed
R11262 T14002 T14004 amod reduced,colonization
R11263 T14003 T14004 amod bacterial,colonization
R11264 T14004 T14001 pobj colonization,with
R11265 T14005 T14004 cc and,colonization
R11266 T14006 T14007 amod little,diarrhea9
R11267 T14007 T14004 conj diarrhea9,colonization
R11268 T14008 T13990 punct .,displayed
R11269 T14009 T14025 mark While,hypothesized
R11270 T14010 T14011 advmod seemingly,paradoxical
R11271 T14011 T14025 advcl paradoxical,hypothesized
R11272 T14012 T14013 punct ",",based
R11273 T14013 T14011 prep based,paradoxical
R11274 T14014 T14013 prep on,based
R11275 T14015 T14018 poss our,data
R11276 T14016 T14017 compound cell,culture
R11277 T14017 T14018 compound culture,data
R11278 T14018 T14014 pobj data,on
R11279 T14019 T14020 punct (,Fig.
R11280 T14020 T14011 appos Fig.,paradoxical
R11281 T14021 T14020 nummod 6d,Fig.
R11282 T14022 T14020 punct ),Fig.
R11283 T14023 T14025 punct ",",hypothesized
R11284 T14024 T14025 nsubj we,hypothesized
R11285 T14025 T14025 ROOT hypothesized,hypothesized
R11286 T14026 T14028 mark that,blocked
R11287 T14027 T14028 nsubj NleH1,blocked
R11288 T14028 T14025 ccomp blocked,hypothesized
R11289 T14029 T14031 nummod RPS3,phosphorylation
R11290 T14030 T14031 nummod S209,phosphorylation
R11291 T14031 T14028 dobj phosphorylation,blocked
R11292 T14032 T14031 prep in,phosphorylation
R11293 T14033 T14032 pobj vivo,in
R11294 T14034 T14028 punct ",",blocked
R11295 T14035 T14036 advmod thereby,preventing
R11296 T14036 T14028 advcl preventing,blocked
R11297 T14037 T14039 amod RPS3,translocation
R11298 T14038 T14039 amod nuclear,translocation
R11299 T14039 T14036 dobj translocation,preventing
R11300 T14040 T14036 prep in,preventing
R11301 T14041 T14042 amod infected,piglets
R11302 T14042 T14040 pobj piglets,in
R11303 T14043 T14025 punct .,hypothesized
R11304 T14044 T14045 nsubj We,isolated
R11305 T14045 T14045 ROOT isolated,isolated
R11381 T14121 T14108 relcl benefit,inhibits
R11382 T14122 T14123 det the,bacterium
R11383 T14123 T14121 dobj bacterium,benefit
R11384 T14124 T14121 prep in,benefit
R11385 T14125 T14124 pobj colonization,in
R11386 T14126 T14125 cc and,colonization
R11387 T14127 T14125 conj transmission,colonization
R11388 T14128 T14105 punct .,demonstrate
R12630 T15728 T15729 nsubj NleH1,steers
R12631 T15729 T15729 ROOT steers,steers
R12632 T15730 T15733 det the,specificities
R12633 T15731 T15732 compound IKKβ,substrate
R12634 T15732 T15733 compound substrate,specificities
R12635 T15733 T15729 dobj specificities,steers
R12636 T15734 T15735 nsubj NleH1,is
R12637 T15735 T15729 conj is,steers
R12638 T15736 T15739 det an,kinase
R12639 T15737 T15739 amod autophosphorylated,kinase
R12640 T15738 T15739 amod serine-threonine,kinase
R12641 T15739 T15735 attr kinase,is
R12642 T15740 T15739 punct ",",kinase
R12643 T15741 T15742 nsubj which,depends
R12644 T15742 T15739 relcl depends,kinase
R12645 T15743 T15742 prep on,depends
R12646 T15744 T15750 det the,9
R12647 T15745 T15750 nmod lysine,9
R12648 T15746 T15745 nummod 159,lysine
R12649 T15747 T15745 punct (,lysine
R12650 T15748 T15745 appos K159,lysine
R12651 T15749 T15750 punct ),9
R12652 T15750 T15743 pobj 9,on
R12653 T15751 T15735 punct .,is
R12654 T15752 T15753 aux To,explore
R12655 T15753 T15766 advcl explore,performed
R12656 T15754 T15755 det the,mechanism
R12657 T15755 T15753 dobj mechanism,explore
R12658 T15756 T15759 prep by,inhibits
R12659 T15757 T15756 pobj which,by
R12660 T15758 T15759 nsubj NleH1,inhibits
R12661 T15759 T15755 relcl inhibits,mechanism
R12662 T15760 T15762 compound RPS3,phosphorylation
R12663 T15761 T15762 compound S209,phosphorylation
R12664 T15762 T15759 dobj phosphorylation,inhibits
R12665 T15763 T15766 punct ",",performed
R12666 T15764 T15766 nsubj we,performed
R12667 T15765 T15766 advmod first,performed
R12668 T15766 T15766 ROOT performed,performed
R12669 T15767 T15771 det an,assay
R12670 T15768 T15771 nmod in,assay
R12671 T15769 T15771 amod vitro,assay
R12672 T15770 T15771 compound kinase,assay
R12673 T15771 T15766 dobj assay,performed
R12674 T15772 T15766 prep with,performed
R12675 T15773 T15776 amod purified,protein
R12676 T15774 T15776 amod wild-type,protein
R12677 T15775 T15776 compound His-NleH1,protein
R12678 T15776 T15772 pobj protein,with
R12679 T15777 T15776 cc and,protein
R12680 T15778 T15780 det a,His-NleH1
R12681 T15779 T15780 amod mutant,His-NleH1
R12682 T15780 T15776 conj His-NleH1,protein
R11356 T14096 T14095 cc and,florid
R11357 T14097 T14095 conj intense,florid
R11358 T14098 T14099 punct (,Fig.
R11359 T14099 T14094 appos Fig.,was
R11360 T14100 T14099 nummod 6f,Fig.
R11361 T14101 T14099 punct ),Fig.
R11362 T14102 T14076 punct .,exhibited
R11363 T14103 T14104 det These,data
R11364 T14104 T14105 nsubj data,demonstrate
R11365 T14105 T14105 ROOT demonstrate,demonstrate
R11366 T14106 T14108 mark that,inhibits
R11367 T14107 T14108 nsubj NleH1,inhibits
R11368 T14108 T14105 ccomp inhibits,demonstrate
R11369 T14109 T14111 compound RPS3,phosphorylation
R11370 T14110 T14111 compound S209,phosphorylation
R11371 T14111 T14108 dobj phosphorylation,inhibits
R11372 T14112 T14113 preconj both,in
R11373 T14113 T14108 prep in,inhibits
R11374 T14114 T14113 pobj vitro,in
R11375 T14115 T14113 cc and,in
R11376 T14116 T14113 conj in,in
R11377 T14117 T14116 pobj vivo,in
R11378 T14118 T14117 punct ",",vivo
R11379 T14119 T14121 nsubj which,benefit
R11380 T14120 T14121 aux might,benefit
R12756 T15854 T15856 nmod Fig.,)
R12757 T15855 T15854 nummod 7b,Fig.
R12758 T15856 T15849 punct ),failed
R12759 T15857 T15839 punct .,reduced
R12764 T15862 T15863 auxpass is,required
R12765 T15863 T15863 ROOT required,required
R12766 T15864 T15865 aux to,protect
R12767 T15865 T15863 xcomp protect,required
R12768 T15866 T15865 dobj RPS3,protect
R12769 T15867 T15865 prep from,protect
R12770 T15868 T15869 amod IKKβ-mediated,phosphorylation
R12771 T15869 T15867 pobj phosphorylation,from
R12772 T15870 T15863 punct .,required
R12773 T15871 T15872 compound Citrobacter,rodentium
R12774 T15872 T15873 nsubj rodentium,is
R12775 T15873 T15895 ccomp is,inhibited
R12776 T15874 T15876 det a,pathogen
R12777 T15875 T15876 compound mouse,pathogen
R12778 T15876 T15873 attr pathogen,is
R12779 T15877 T15878 nsubj that,shares
R12780 T15878 T15876 relcl shares,pathogen
R12781 T15879 T15880 amod pathogenic,strategies
R12782 T15880 T15878 dobj strategies,shares
R12783 T15881 T15880 prep with,strategies
R12784 T15882 T15883 compound E.,coli
R12785 T15883 T15881 pobj coli,with
R12786 T15884 T15883 appos 39,coli
R12787 T15885 T15883 punct ",",coli
R12788 T15886 T15887 advmod most,notably
R12789 T15887 T15888 advmod notably,for
R12790 T15888 T15878 prep for,shares
R12791 T15889 T15890 poss our,investigation
R12792 T15890 T15888 pobj investigation,for
R12793 T15891 T15895 punct ",",inhibited
R12794 T15892 T15894 compound C.,NleH
R12795 T15893 T15894 compound rodentium,NleH
R12796 T15894 T15895 nsubj NleH,inhibited
R12797 T15895 T15895 ROOT inhibited,inhibited
R12798 T15896 T15898 nummod RPS3,translocation
R12799 T15897 T15898 amod nuclear,translocation
R12800 T15898 T15895 dobj translocation,inhibited
R12801 T15899 T15898 cc and,translocation
R12802 T15900 T15903 amod RPS3-dependent,activity
R12803 T15901 T15903 compound NF-κB,activity
R12804 T15902 T15903 compound luciferase,activity
R12805 T15903 T15898 conj activity,translocation
R12806 T15904 T15895 prep to,inhibited
R12807 T15905 T15906 det an,extent
R12808 T15906 T15904 pobj extent,to
R12809 T15907 T15906 amod equivalent,extent
R12810 T15908 T15907 prep to,equivalent
R12811 T15909 T15911 compound E.,NleH1
R12812 T15910 T15911 compound coli,NleH1
R12813 T15911 T15908 pobj NleH1,to
R12814 T15912 T15911 punct (,NleH1
R12815 T15913 T15911 appos ref,NleH1
R12816 T15914 T15915 punct .,9
R12817 T15915 T15915 ROOT 9,9
R12818 T15916 T15915 punct ),9
R12819 T15917 T15895 punct .,inhibited
R12820 T15918 T15919 nsubj We,assayed
R12821 T15919 T15919 ROOT assayed,assayed
R12822 T15920 T15922 compound RPS3,phosphorylation
R12823 T15921 T15922 compound S209,phosphorylation
R12824 T15922 T15919 dobj phosphorylation,assayed
R12825 T15923 T15919 prep in,assayed
R12826 T15924 T15925 compound HeLa,cells
R12827 T15925 T15923 pobj cells,in
R12828 T15926 T15925 acl infected,cells
R12829 T15927 T15926 prep with,infected
R12830 T15928 T15931 amod different,strains
R12831 T15929 T15931 nmod C.,strains
R12832 T15930 T15931 compound rodentium,strains
R12833 T15931 T15927 pobj strains,with
R12834 T15932 T15919 punct .,assayed
R12985 T16083 T16079 xcomp impair,is
R12986 T16084 T16087 det the,translocation
R12987 T16085 T16087 amod strong,translocation
R12988 T16086 T16087 amod nuclear,translocation
R12683 T15781 T15780 punct (,His-NleH1
R12684 T15782 T15780 appos K159A,His-NleH1
R12685 T15783 T15782 punct ),K159A
R12686 T15784 T15780 conj protein,His-NleH1
R12687 T15785 T15766 punct ",",performed
R12688 T15786 T15766 advcl confirming,performed
R12689 T15787 T15789 mark that,is
R12690 T15788 T15789 nsubj NleH1,is
R12691 T15789 T15786 ccomp is,confirming
R12692 T15790 T15789 acomp autophosphorylated,is
R12693 T15791 T15790 cc and,autophosphorylated
R12694 T15792 T15793 det the,K159A
R12695 T15793 T15794 nsubj K159A,is
R12696 T15794 T15790 conj is,autophosphorylated
R12697 T15795 T15798 det an,mutant
R12698 T15796 T15798 amod NleH1,mutant
R12699 T15797 T15798 compound kinase-dead,mutant
R12700 T15798 T15794 attr mutant,is
R12701 T15799 T15802 punct (,)
R12702 T15800 T15802 nmod Fig.,)
R12703 T15801 T15800 nummod 7a,Fig.
R12704 T15802 T15794 punct ),is
R12705 T15803 T15766 punct .,performed
R12706 T15804 T15805 aux To,examine
R12707 T15805 T15825 advcl examine,expressing
R12708 T15806 T15811 mark whether,required
R12709 T15807 T15809 det the,activity
R12710 T15808 T15809 compound kinase,activity
R12711 T15809 T15811 nsubjpass activity,required
R12712 T15810 T15811 auxpass is,required
R12713 T15811 T15805 ccomp required,examine
R12714 T15812 T15815 mark for,inhibit
R12715 T15813 T15815 nsubj NleH1,inhibit
R12716 T15814 T15815 aux to,inhibit
R12717 T15815 T15811 advcl inhibit,required
R12718 T15816 T15817 compound IKKβ,phosphorlyation
R12719 T15817 T15815 dobj phosphorlyation,inhibit
R12720 T15818 T15817 prep of,phosphorlyation
R12721 T15819 T15818 pobj RPS3,of
R12722 T15820 T15817 prep on,phosphorlyation
R12723 T15821 T15820 pobj S209,on
R12724 T15822 T15825 punct ",",expressing
R12725 T15823 T15825 nsubj we,expressing
R12726 T15824 T15825 advmod ectopically,expressing
R12727 T15825 T15825 ROOT expressing,expressing
R12728 T15826 T15827 preconj either,wild-type
R12729 T15827 T15825 dobj wild-type,expressing
R12730 T15828 T15827 cc or,wild-type
R12731 T15829 T15830 compound K159A,NleH1
R12732 T15830 T15827 conj NleH1,wild-type
R12733 T15831 T15830 prep in,NleH1
R12734 T15832 T15833 compound 293T,cells
R12735 T15833 T15831 pobj cells,in
R12736 T15834 T15825 punct .,expressing
R12737 T15835 T15837 amod Wild-type,expression
R12738 T15836 T15837 compound NleH1,expression
R12739 T15837 T15839 nsubj expression,reduced
R12740 T15838 T15839 advmod significantly,reduced
R12741 T15839 T15839 ROOT reduced,reduced
R12742 T15840 T15843 amod TNF-induced,phosphorylation
R12743 T15841 T15843 compound RPS3,phosphorylation
R12744 T15842 T15843 compound S209,phosphorylation
R12745 T15843 T15839 dobj phosphorylation,reduced
R12746 T15844 T15839 punct ",",reduced
R12747 T15845 T15849 mark whereas,failed
R12748 T15846 T15848 det the,mutant
R12749 T15847 T15848 compound K159A,mutant
R12750 T15848 T15849 nsubj mutant,failed
R12751 T15849 T15839 advcl failed,reduced
R12752 T15850 T15851 aux to,do
R12753 T15851 T15849 xcomp do,failed
R12754 T15852 T15851 advmod so,do
R12755 T15853 T15854 punct (,Fig.
R12835 T15933 T15938 prep In,stimulated
R12836 T15934 T15935 amod uninfected,cells
R12837 T15935 T15933 pobj cells,In
R12838 T15936 T15938 punct ",",stimulated
R12839 T15937 T15938 nsubj TNF-treatment,stimulated
R12840 T15938 T15938 ROOT stimulated,stimulated
R12841 T15939 T15942 det a,increase
R12842 T15940 T15942 nmod ∼,increase
R12843 T15941 T15942 amod 3.5-fold,increase
R12844 T15942 T15938 dobj increase,stimulated
R12845 T15943 T15942 prep in,increase
R12846 T15944 T15946 compound RPS3,phosphorylation
R12847 T15945 T15946 compound S209,phosphorylation
R12848 T15946 T15943 pobj phosphorylation,in
R12849 T15947 T15948 punct (,Fig.
R12850 T15948 T15942 appos Fig.,increase
R12851 T15949 T15948 nummod 7c,Fig.
R12852 T15950 T15948 punct ),Fig.
R12853 T15951 T15938 punct .,stimulated
R12854 T15952 T15953 amod Such,augmentation
R12855 T15953 T15958 nsubjpass augmentation,reduced
R12856 T15954 T15953 prep of,augmentation
R12857 T15955 T15956 nummod RPS3,phosphorylation
R12858 T15956 T15954 pobj phosphorylation,of
R12859 T15957 T15958 auxpass was,reduced
R12860 T15958 T15958 ROOT reduced,reduced
R12861 T15959 T15958 prep by,reduced
R12862 T15960 T15961 advmod about,60
R12863 T15961 T15962 nummod 60,%
R12864 T15962 T15959 pobj %,by
R12865 T15963 T15958 agent by,reduced
R12866 T15964 T15967 amod wild-type,infection
R12867 T15965 T15966 compound C.,rodentium
R12868 T15966 T15967 compound rodentium,infection
R12869 T15967 T15963 pobj infection,by
R12870 T15968 T15969 punct (,Fig.
R12871 T15969 T15970 compound Fig.,7c
R12872 T15970 T15967 appos 7c,infection
R12873 T15971 T15967 punct ),infection
R12874 T15972 T15958 punct .,reduced
R12875 T15973 T15978 advmod However,enhanced
R12876 T15974 T15978 punct ",",enhanced
R12877 T15975 T15976 amod RPS3,phosphorylation
R12878 T15976 T15978 nsubjpass phosphorylation,enhanced
R12879 T15977 T15978 auxpass was,enhanced
R12880 T15978 T15978 ROOT enhanced,enhanced
R12881 T15979 T15982 advmod when,infected
R12882 T15980 T15982 nsubjpass cells,infected
R12883 T15981 T15982 auxpass were,infected
R12884 T15982 T15978 advcl infected,enhanced
R12885 T15983 T15982 prep with,infected
R12886 T15984 T15987 det a,strain
R12887 T15985 T15987 compound C.,strain
R12888 T15986 T15987 compound rodentium,strain
R12889 T15987 T15983 pobj strain,with
R12890 T15988 T15987 acl lacking,strain
R12891 T15989 T15988 dobj NleH,lacking
R12892 T15990 T15989 punct (,NleH
R12893 T15991 T15992 compound Fig.,7c
R12894 T15992 T15989 appos 7c,NleH
R12895 T15993 T15989 punct ",",NleH
R12896 T15994 T15989 appos ΔnleH,NleH
R12897 T15995 T15989 punct ),NleH
R12898 T15996 T15978 punct .,enhanced
R12899 T15997 T15999 nsubj We,examined
R12900 T15998 T15999 advmod further,examined
R12901 T15999 T15999 ROOT examined,examined
R12902 T16000 T16001 det the,role
R12903 T16001 T15999 dobj role,examined
R12904 T16002 T16001 prep of,role
R12905 T16003 T16005 amod NleH1,activity
R12906 T16004 T16005 compound kinase,activity
R12907 T16005 T16002 pobj activity,of
R12908 T16006 T15999 advcl using,examined
R12909 T16007 T16011 det the,strain
R12910 T16008 T16010 compound C.,ΔnleH
R12911 T16009 T16010 compound rodentium,ΔnleH
R12912 T16010 T16011 compound ΔnleH,strain
R12913 T16011 T16006 dobj strain,using
R12914 T16012 T16006 prep as,using
R12915 T16013 T16014 det a,background
R12916 T16014 T16012 pobj background,as
R12917 T16015 T16018 prep on,express
R12918 T16016 T16015 pobj which,on
R12919 T16017 T16018 aux to,express
R12989 T16087 T16083 dobj translocation,impair
R12990 T16088 T16087 prep of,translocation
R12991 T16089 T16088 pobj RPS3,of
R12992 T16090 T16087 acl trigged,translocation
R12993 T16091 T16090 agent by,trigged
R12994 T16092 T16094 det the,IKKβ
R12995 T16093 T16094 compound constitutively-active,IKKβ
R12996 T16094 T16091 pobj IKKβ,by
R12997 T16095 T16099 punct (,]
R12998 T16096 T16099 compound IKKβ,]
R12999 T16097 T16099 compound [,]
R13000 T16098 T16099 compound SSEE,]
R13001 T16099 T16094 appos ],IKKβ
R13002 T16100 T16099 punct ),]
R13003 T16101 T16102 punct (,Fig.
R13004 T16102 T16094 appos Fig.,IKKβ
R13005 T16103 T16102 nummod 2d,Fig.
R13006 T16104 T16094 punct ),IKKβ
R13007 T16105 T16072 punct .,examined
R13008 T16106 T16107 nsubj We,found
R13009 T16107 T16107 ROOT found,found
R13010 T16108 T16118 mark that,triggered
R13011 T16109 T16110 advmod ectopically,expressing
R13012 T16110 T16118 advcl expressing,triggered
R13013 T16111 T16112 preconj either,wild-type
R13014 T16112 T16110 dobj wild-type,expressing
R13015 T16113 T16112 cc or,wild-type
R13016 T16114 T16115 compound SSEE,IKKβ
R13017 T16115 T16112 conj IKKβ,wild-type
R13018 T16116 T16112 conj proteins,wild-type
R13019 T16117 T16118 punct ",",triggered
R13020 T16118 T16107 ccomp triggered,found
R13021 T16119 T16120 advmod more,RPS3
R13022 T16120 T16122 amod RPS3,translocation
R13023 T16121 T16122 amod nuclear,translocation
R13024 T16122 T16118 dobj translocation,triggered
R13025 T16123 T16122 prep than,translocation
R13026 T16124 T16126 det the,IKKβ
R13027 T16125 T16126 compound kinase-dead,IKKβ
R13028 T16126 T16130 nmod IKKβ,protein
R13029 T16127 T16126 punct (,IKKβ
R13030 T16128 T16126 appos SSAA,IKKβ
R13031 T16129 T16126 punct ),IKKβ
R13032 T16130 T16123 pobj protein,than
R13033 T16131 T16130 punct (,protein
R13034 T16132 T16130 appos Fig.,protein
R13035 T16133 T16132 nummod 7d,Fig.
R13036 T16134 T16130 punct ),protein
R13037 T16135 T16107 punct .,found
R13038 T16136 T16138 nummod RPS3,accumulation
R13039 T16137 T16138 amod nuclear,accumulation
R13040 T16138 T16139 nsubj accumulation,was
R13041 T16139 T16139 ROOT was,was
R13042 T16140 T16141 advmod substantially,retarded
R13043 T16141 T16139 acomp retarded,was
R13044 T16142 T16139 prep by,was
R13045 T16143 T16142 pcomp infecting,by
R13046 T16144 T16143 dobj cells,infecting
R13047 T16145 T16143 prep with,infecting
R13048 T16146 T16149 amod wild-type,O157
R13049 T16147 T16149 compound E.,O157
R13050 T16148 T16149 compound coli,O157
R13051 T16149 T16145 pobj O157,with
R13052 T16150 T16149 punct :,O157
R13053 T16151 T16149 appos H7,O157
R13054 T16152 T16153 punct (,Fig.
R13055 T16153 T16151 appos Fig.,H7
R13056 T16154 T16153 nummod 7d,Fig.
R13057 T16155 T16151 punct ),H7
R13058 T16156 T16139 punct .,was
R13059 T16157 T16160 prep In,infecting
R13135 T16233 T16234 amod nuclear,translocation
R13136 T16234 T16231 dobj translocation,inhibit
R13137 T16235 T16236 advmod even,in
R13138 T16236 T16231 prep in,inhibit
R13139 T16237 T16236 pobj cells,in
R13140 T16238 T16237 acl expressing,cells
R13141 T16239 T16240 compound constitutively-activated,IKKβ
R13142 T16240 T16238 dobj IKKβ,expressing
R13143 T16241 T16227 punct .,is
R13144 T16242 T16243 nsubj We,examined
R13145 T16243 T16243 ROOT examined,examined
R13146 T16244 T16248 mark whether,phosphorylate
R13147 T16245 T16248 nsubj NleH1,phosphorylate
R13148 T16246 T16248 aux could,phosphorylate
R13149 T16247 T16248 advmod directly,phosphorylate
R13150 T16248 T16243 ccomp phosphorylate,examined
R13151 T16249 T16248 dobj IKKβ,phosphorylate
R13152 T16250 T16251 advmod thus,inhibiting
R13153 T16251 T16248 advcl inhibiting,phosphorylate
R13154 T16252 T16255 amod IKKβ-mediated,phosphorylation
R13155 T16253 T16255 nummod RPS3,phosphorylation
R13156 T16254 T16255 nummod S209,phosphorylation
R13157 T16255 T16251 dobj phosphorylation,inhibiting
R13158 T16256 T16243 punct .,examined
R13159 T16257 T16258 nsubj We,performed
R13160 T16258 T16258 ROOT performed,performed
R13161 T16259 T16258 prep in,performed
R13162 T16260 T16261 amod vitro,kinase
R13163 T16261 T16262 compound kinase,assays
R13164 T16262 T16259 pobj assays,in
R13165 T16263 T16262 advcl using,assays
R13166 T16264 T16265 amod immunoprecipitated,Flag-IKKβ
R13167 T16265 T16263 dobj Flag-IKKβ,using
R12920 T16018 T16014 relcl express,background
R12921 T16019 T16020 preconj either,wild-type
R12922 T16020 T16018 dobj wild-type,express
R12923 T16021 T16020 cc or,wild-type
R12924 T16022 T16025 compound K159A,NleH1
R12925 T16023 T16025 compound E.,NleH1
R12926 T16024 T16025 compound coli,NleH1
R12927 T16025 T16020 conj NleH1,wild-type
R12928 T16026 T15999 punct .,examined
R12929 T16027 T16027 ROOT Complementing,Complementing
R12930 T16028 T16034 nsubj ΔnleH,abolished
R12931 T16029 T16028 amod mutant,ΔnleH
R12932 T16030 T16029 prep with,mutant
R12933 T16031 T16032 compound wild-type,NleH1
R12934 T16032 T16030 pobj NleH1,with
R12935 T16033 T16034 advmod almost,abolished
R12936 T16034 T16034 ROOT abolished,abolished
R12937 T16035 T16038 amod TNF-induced,phosphorylation
R12938 T16036 T16037 compound RPS3,S209
R12939 T16037 T16038 compound S209,phosphorylation
R12940 T16038 T16034 dobj phosphorylation,abolished
R12941 T16039 T16043 mark whereas,failed
R12942 T16040 T16039 pcomp complementing,whereas
R12943 T16041 T16040 prep with,complementing
R12944 T16042 T16041 pobj K159A,with
R12945 T16043 T16034 advcl failed,abolished
R12946 T16044 T16045 aux to,inhibit
R12947 T16045 T16043 xcomp inhibit,failed
R12948 T16046 T16047 amod RPS3,phosphorylation
R12949 T16047 T16045 dobj phosphorylation,inhibit
R12950 T16048 T16049 punct (,Fig.
R12951 T16049 T16047 appos Fig.,phosphorylation
R12952 T16050 T16049 nummod 7c,Fig.
R12953 T16051 T16049 punct ),Fig.
R12954 T16052 T16034 punct .,abolished
R12955 T16053 T16057 advmod Collectively,demonstrate
R12956 T16054 T16057 punct ",",demonstrate
R12957 T16055 T16056 det these,results
R12958 T16056 T16057 nsubj results,demonstrate
R12959 T16057 T16057 ROOT demonstrate,demonstrate
R12960 T16058 T16063 mark that,required
R12961 T16059 T16061 amod NleH1,activity
R12962 T16060 T16061 compound kinase,activity
R12963 T16061 T16063 nsubjpass activity,required
R12964 T16062 T16063 auxpass is,required
R12965 T16063 T16057 ccomp required,demonstrate
R12966 T16064 T16065 aux to,block
R12967 T16065 T16063 xcomp block,required
R12968 T16066 T16068 compound RPS3,phosphorylation
R12969 T16067 T16068 compound S209,phosphorylation
R12970 T16068 T16065 dobj phosphorylation,block
R12971 T16069 T16057 punct .,demonstrate
R12972 T16070 T16072 nsubj We,examined
R12973 T16071 T16072 advmod next,examined
R12974 T16072 T16072 ROOT examined,examined
R12975 T16073 T16079 mark whether,is
R12976 T16074 T16076 det the,activity
R12977 T16075 T16076 amod inhibitory,activity
R12978 T16076 T16079 nsubj activity,is
R12979 T16077 T16076 prep of,activity
R12980 T16078 T16077 pobj NleH1,of
R12981 T16079 T16072 ccomp is,examined
R12982 T16080 T16081 advmod sufficiently,robust
R12983 T16081 T16079 acomp robust,is
R12984 T16082 T16083 aux to,impair
R13060 T16158 T16157 pobj contrast,In
R13061 T16159 T16160 punct ",",infecting
R13062 T16160 T16160 ROOT infecting,infecting
R13063 T16161 T16160 prep with,infecting
R13064 T16162 T16163 det either,ΔnleH1
R13065 T16163 T16161 pobj ΔnleH1,with
R13066 T16164 T16163 cc or,ΔnleH1
R13067 T16165 T16163 conj ΔescN,ΔnleH1
R13068 T16166 T16160 dobj strains,infecting
R13069 T16167 T16168 advmod only,slightly
R13070 T16168 T16169 advmod slightly,impaired
R13071 T16169 T16166 acl impaired,strains
R13072 T16170 T16172 nmod RPS3,translocation
R13073 T16171 T16172 amod nuclear,translocation
R13074 T16172 T16169 dobj translocation,impaired
R13075 T16173 T16169 prep in,impaired
R13076 T16174 T16175 preconj either,IKKβ
R13077 T16175 T16173 pobj IKKβ,in
R13078 T16176 T16175 punct -,IKKβ
R13079 T16177 T16175 cc or,IKKβ
R13080 T16178 T16175 conj IKKβ,IKKβ
R13081 T16179 T16178 punct (,IKKβ
R13082 T16180 T16178 appos SSEE,IKKβ
R13083 T16181 T16178 punct ),IKKβ
R13084 T16182 T16183 punct -,expressing
R13085 T16183 T16166 acl expressing,strains
R13086 T16184 T16183 dobj cells,expressing
R13087 T16185 T16183 punct (,expressing
R13088 T16186 T16188 nmod Fig.,)
R13089 T16187 T16186 nummod 7d,Fig.
R13090 T16188 T16183 punct ),expressing
R13091 T16189 T16160 punct .,infecting
R13092 T16190 T16191 mark As,expected
R13093 T16191 T16198 advcl expected,affect
R13094 T16192 T16198 punct ",",affect
R13095 T16193 T16195 compound E.,infections
R13096 T16194 T16195 compound coli,infections
R13097 T16195 T16198 nsubj infections,affect
R13098 T16196 T16198 aux did,affect
R13099 T16197 T16198 neg not,affect
R13100 T16198 T16198 ROOT affect,affect
R13101 T16199 T16202 det the,translocation
R13102 T16200 T16202 amod RPS3,translocation
R13103 T16201 T16202 amod nuclear,translocation
R13104 T16202 T16198 dobj translocation,affect
R13105 T16203 T16202 prep in,translocation
R13106 T16204 T16203 pobj IKKβ,in
R13107 T16205 T16204 punct (,IKKβ
R13108 T16206 T16204 appos SSAA,IKKβ
R13109 T16207 T16204 punct ),IKKβ
R13110 T16208 T16202 punct -,translocation
R13111 T16209 T16202 acl expressing,translocation
R13112 T16210 T16209 dobj cells,expressing
R13113 T16211 T16209 punct ",",expressing
R13114 T16212 T16215 advmod where,was
R13115 T16213 T16214 amod NF-κB,signaling
R13116 T16214 T16215 nsubj signaling,was
R13117 T16215 T16202 relcl was,translocation
R13118 T16216 T16215 acomp low,was
R13119 T16217 T16218 punct (,Fig.
R13120 T16218 T16202 appos Fig.,translocation
R13121 T16219 T16218 nummod 7d,Fig.
R13122 T16220 T16218 punct ),Fig.
R13123 T16221 T16198 punct .,affect
R13124 T16222 T16227 advmod Thus,is
R13125 T16223 T16227 punct ",",is
R13126 T16224 T16227 prep during,is
R13127 T16225 T16224 pobj infection,during
R13128 T16226 T16227 nsubj NleH1,is
R13129 T16227 T16227 ROOT is,is
R13130 T16228 T16229 advmod sufficiently,potent
R13131 T16229 T16227 acomp potent,is
R13132 T16230 T16231 aux to,inhibit
R13133 T16231 T16229 xcomp inhibit,potent
R13134 T16232 T16234 amod RPS3,translocation
R13209 T16307 T16306 prt out,ruling
R13210 T16308 T16309 det this,possibility
R13211 T16309 T16306 dobj possibility,ruling
R13212 T16310 T16292 punct .,observe
R13213 T16311 T16313 nsubj We,tested
R13214 T16312 T16313 advmod then,tested
R13215 T16313 T16313 ROOT tested,tested
R13216 T16314 T16315 det the,hypothesis
R13217 T16315 T16313 dobj hypothesis,tested
R13218 T16316 T16319 mark that,alter
R13219 T16317 T16319 nsubj NleH1,alter
R13220 T16318 T16319 aux could,alter
R13221 T16319 T16315 acl alter,hypothesis
R13222 T16320 T16322 det the,substrate
R13223 T16321 T16322 compound IKKβ,substrate
R13224 T16322 T16323 compound substrate,specificities
R13225 T16323 T16319 dobj specificities,alter
R13226 T16324 T16313 punct .,tested
R13168 T16266 T16267 punct (,K44A
R13169 T16267 T16265 appos K44A,Flag-IKKβ
R13170 T16268 T16265 punct ),Flag-IKKβ
R13171 T16269 T16263 prep as,using
R13172 T16270 T16269 pobj substrate,as
R13173 T16271 T16270 cc and,substrate
R13174 T16272 T16273 amod recombinant,His-NleH1
R13175 T16273 T16270 conj His-NleH1,substrate
R13176 T16274 T16263 prep as,using
R13177 T16275 T16274 pobj kinase,as
R13178 T16276 T16262 punct ",",assays
R13179 T16277 T16283 mark so,obscure
R13180 T16278 T16283 mark that,obscure
R13181 T16279 T16280 compound IKKβ,autophosphorylation
R13182 T16280 T16283 nsubj autophosphorylation,obscure
R13183 T16281 T16283 aux would,obscure
R13184 T16282 T16283 neg not,obscure
R13185 T16283 T16258 advcl obscure,performed
R13186 T16284 T16285 amod NleH1-induced,phosphorylation
R13187 T16285 T16283 dobj phosphorylation,obscure
R13188 T16286 T16258 punct .,performed
R13189 T16287 T16292 advmod However,observe
R13190 T16288 T16292 punct ",",observe
R13191 T16289 T16292 nsubj we,observe
R13192 T16290 T16292 aux did,observe
R13193 T16291 T16292 neg not,observe
R13194 T16292 T16292 ROOT observe,observe
R13195 T16293 T16296 det any,incorporation
R13196 T16294 T16296 amod detectable,incorporation
R13197 T16295 T16296 compound 32P,incorporation
R13198 T16296 T16292 dobj incorporation,observe
R13199 T16297 T16296 prep in,incorporation
R13200 T16298 T16297 pobj IKKβ,in
R13201 T16299 T16301 punct (,Fig.
R13202 T16300 T16301 compound Supplementary,Fig.
R13203 T16301 T16298 appos Fig.,IKKβ
R13204 T16302 T16301 nummod 13,Fig.
R13205 T16303 T16301 punct ),Fig.
R13206 T16304 T16292 punct ",",observe
R13207 T16305 T16306 advmod thus,ruling
R13208 T16306 T16292 advcl ruling,observe
R13359 T16457 T16438 punct :,specificity
R13360 T16458 T16438 appos H7,specificity
R13361 T16459 T16460 aux to,alter
R13362 T16460 T16438 acl alter,specificity
R13363 T16461 T16462 det the,host
R13364 T16462 T16465 amod host,response
R13365 T16463 T16465 amod innate,response
R13366 T16464 T16465 amod immune,response
R13367 T16465 T16460 dobj response,alter
R13368 T16466 T16434 punct .,blocks
R15050 T18827 T18830 nsubjpass RPS3,demonstrated
R15051 T18828 T18830 auxpass was,demonstrated
R15052 T18829 T18830 advmod previously,demonstrated
R15053 T18830 T18830 ROOT demonstrated,demonstrated
R15054 T18831 T18832 aux to,function
R15055 T18832 T18830 xcomp function,demonstrated
R15056 T18833 T18832 prep as,function
R15057 T18834 T18836 det an,subunit
R15058 T18835 T18836 amod integral,subunit
R15059 T18836 T18833 pobj subunit,as
R15060 T18837 T18836 acl conferring,subunit
R15061 T18838 T18840 amod NF-κB,specificity6
R15062 T18839 T18840 amod regulatory,specificity6
R15063 T18840 T18837 dobj specificity6,conferring
R15064 T18841 T18830 punct .,demonstrated
R15065 T18842 T18844 advmod Here,sought
R15066 T18843 T18844 nsubj we,sought
R15067 T18844 T18844 ROOT sought,sought
R15068 T18845 T18846 aux to,elucidate
R15069 T18846 T18844 xcomp elucidate,sought
R15070 T18847 T18851 advmod how,triggers
R15071 T18848 T18849 amod NF-κB,activation
R15072 T18849 T18851 nsubj activation,triggers
R15073 T18850 T18851 nsubj signaling,triggers
R15074 T18851 T18846 ccomp triggers,elucidate
R15075 T18852 T18851 dobj RPS3,triggers
R15076 T18853 T18854 aux to,translocate
R15077 T18854 T18846 advcl translocate,elucidate
R15078 T18855 T18854 cc and,translocate
R15079 T18856 T18854 conj participate,translocate
R15080 T18857 T18856 prep in,participate
R15081 T18858 T18859 amod NF-κB,function
R15082 T18859 T18857 pobj function,in
R15083 T18860 T18859 prep in,function
R15084 T18861 T18862 det the,nucleus
R15085 T18862 T18860 pobj nucleus,in
R15086 T18863 T18844 punct .,sought
R15087 T18864 T18865 nsubj We,demonstrate
R15163 T18940 T18941 nummod specificity29,coincides
R15164 T18941 T18933 appos coincides,observation
R15165 T18942 T18941 prep with,coincides
R15166 T18943 T18944 poss our,evidence
R15167 T18944 T18942 pobj evidence,with
R15168 T18945 T18944 mark that,evidence
R15169 T18946 T18947 compound recombinant,IKKβ
R15170 T18947 T18945 nsubj IKKβ,that
R15171 T18948 T18947 punct ",",IKKβ
R15172 T18949 T18947 cc but,IKKβ
R15173 T18950 T18949 neg not,but
R15174 T18951 T18947 conj IKKα,IKKβ
R15175 T18952 T18953 punct ",",phosphorylated
R15176 T18953 T18954 compound phosphorylated,RPS3
R15177 T18954 T18947 conj RPS3,IKKβ
R15178 T18955 T18933 punct .,observation
R15179 T18956 T18957 nsubj We,found
R15180 T18957 T18957 ROOT found,found
R13227 T16325 T16330 prep To,performed
R13228 T16326 T16327 det this,end
R13229 T16327 T16325 pobj end,To
R13230 T16328 T16330 punct ",",performed
R13231 T16329 T16330 nsubj we,performed
R13232 T16330 T16330 ROOT performed,performed
R13233 T16331 T16330 prep in,performed
R13234 T16332 T16333 amod vitro,kinase
R13235 T16333 T16334 compound kinase,assays
R13236 T16334 T16331 pobj assays,in
R13237 T16335 T16334 advcl using,assays
R13238 T16336 T16337 det both,CK2
R13239 T16337 T16335 dobj CK2,using
R13240 T16338 T16337 cc and,CK2
R13241 T16339 T16340 compound IKK,substrates
R13242 T16340 T16337 conj substrates,CK2
R13243 T16341 T16340 prep for,substrates
R13244 T16342 T16341 pobj IKKβ,for
R13245 T16343 T16330 punct .,performed
R13246 T16344 T16345 mark As,expected
R13247 T16345 T16348 advcl expected,phosphorylated
R13248 T16346 T16348 punct ",",phosphorylated
R13249 T16347 T16348 nsubj IKKβ,phosphorylated
R13250 T16348 T16348 ROOT phosphorylated,phosphorylated
R13251 T16349 T16348 dobj RPS3,phosphorylated
R13252 T16350 T16351 punct (,Fig.
R13253 T16351 T16352 compound Fig.,7e
R13254 T16352 T16349 appos 7e,RPS3
R13255 T16353 T16352 punct ",",7e
R13256 T16354 T16352 appos lane,7e
R13257 T16355 T16354 nummod 7,lane
R13258 T16356 T16352 punct ),7e
R13259 T16357 T16349 cc and,RPS3
R13260 T16358 T16349 conj GST-IκBα,RPS3
R13261 T16359 T16358 punct (,GST-IκBα
R13262 T16360 T16358 parataxis 1-54,GST-IκBα
R13263 T16361 T16358 punct ),GST-IκBα
R13264 T16362 T16349 conj protein,RPS3
R13265 T16363 T16362 punct (,protein
R13266 T16364 T16365 compound Fig.,7e
R13267 T16365 T16362 appos 7e,protein
R13268 T16366 T16365 punct ",",7e
R13269 T16367 T16368 nmod lane,9
R13270 T16368 T16365 conj 9,7e
R13271 T16369 T16365 punct ),7e
R13272 T16370 T16362 punct ",",protein
R13273 T16371 T16348 advcl demonstrating,phosphorylated
R13274 T16372 T16373 nsubj it,harbors
R13275 T16373 T16371 ccomp harbors,demonstrating
R13276 T16374 T16375 preconj either,CK2
R13277 T16375 T16373 dobj CK2,harbors
R13278 T16376 T16375 cc or,CK2
R13279 T16377 T16379 compound IKK,specificity
R13280 T16378 T16379 compound substrate,specificity
R13281 T16379 T16375 conj specificity,CK2
R13282 T16380 T16348 punct .,phosphorylated
R13283 T16381 T16386 nsubj Preincubation,reduced
R13284 T16382 T16381 prep of,Preincubation
R13285 T16383 T16382 pobj IKKβ,of
R13286 T16384 T16381 prep with,Preincubation
R13287 T16385 T16384 pobj NleH1,with
R13288 T16386 T16386 ROOT reduced,reduced
R13289 T16387 T16389 nmod IKKβ-mediated,phosphorylation
R13290 T16388 T16389 amod RPS3,phosphorylation
R13291 T16389 T16386 dobj phosphorylation,reduced
R13292 T16390 T16389 punct ",",phosphorylation
R13293 T16391 T16395 advmod i.e.,specificity
R13294 T16392 T16395 det the,specificity
R13295 T16393 T16395 compound CK2,specificity
R13296 T16394 T16395 compound kinase,specificity
R13297 T16395 T16389 appos specificity,phosphorylation
R13298 T16396 T16395 punct ",",specificity
R13299 T16397 T16395 cc but,specificity
R13300 T16398 T16399 neg not,IKKβ-mediated
R13301 T16399 T16401 amod IKKβ-mediated,phosphorylation
R13302 T16400 T16401 amod GST-IκBα,phosphorylation
R13303 T16401 T16395 conj phosphorylation,specificity
R13304 T16402 T16401 punct ",",phosphorylation
R13305 T16403 T16407 advmod i.e.,specificity
R13306 T16404 T16407 det the,specificity
R13307 T16405 T16407 nmod IKK,specificity
R13308 T16406 T16407 compound kinase,specificity
R13309 T16407 T16401 appos specificity,phosphorylation
R13310 T16408 T16407 punct (,specificity
R13311 T16409 T16407 appos Fig.,specificity
R13312 T16410 T16409 nummod 7e,Fig.
R13313 T16411 T16407 punct ),specificity
R13314 T16412 T16386 punct .,reduced
R13315 T16413 T16414 compound Control,experiments
R13316 T16414 T16415 nsubj experiments,revealed
R13317 T16415 T16415 ROOT revealed,revealed
R13318 T16416 T16418 det no,phosphorylation
R13319 T16417 T16418 amod NleH1-mediated,phosphorylation
R13320 T16418 T16415 dobj phosphorylation,revealed
R13321 T16419 T16418 cc or,phosphorylation
R13322 T16420 T16418 conj autophosphorylation,phosphorylation
R13323 T16421 T16418 prep of,phosphorylation
R13324 T16422 T16421 pobj RPS3,of
R13325 T16423 T16422 cc or,RPS3
R13326 T16424 T16422 conj GST-IκBα,RPS3
R13327 T16425 T16426 punct (,Fig.
R13328 T16426 T16424 appos Fig.,GST-IκBα
R13329 T16427 T16426 nummod 7e,Fig.
R13330 T16428 T16424 punct ),GST-IκBα
R13331 T16429 T16415 punct .,revealed
R13332 T16430 T16434 advcl Taken,blocks
R13333 T16431 T16430 advmod together,Taken
R13334 T16432 T16434 punct ",",blocks
R13335 T16433 T16434 nsubj NleH1,blocks
R13336 T16434 T16434 ROOT blocks,blocks
R13337 T16435 T16438 det the,specificity
R13338 T16436 T16438 compound CK2,specificity
R13339 T16437 T16438 compound substrate,specificity
R13340 T16438 T16434 dobj specificity,blocks
R13341 T16439 T16438 prep of,specificity
R13342 T16440 T16439 pobj IKKβ,of
R13343 T16441 T16442 advmod thus,inhibiting
R13344 T16442 T16438 acl inhibiting,specificity
R13345 T16443 T16447 det the,phosphorylation
R13346 T16444 T16447 amod IKKβ-mediated,phosphorylation
R13347 T16445 T16446 nummod RPS3,S209
R13348 T16446 T16447 nummod S209,phosphorylation
R13349 T16447 T16442 dobj phosphorylation,inhibiting
R13350 T16448 T16449 advmod thus,representing
R13351 T16449 T16438 acl representing,specificity
R13352 T16450 T16452 det a,strategy
R13353 T16451 T16452 compound novel,strategy
R13354 T16452 T16449 dobj strategy,representing
R13355 T16453 T16452 prep by,strategy
R13356 T16454 T16456 compound E.,O157
R13357 T16455 T16456 compound coli,O157
R13358 T16456 T16453 pobj O157,by
R15088 T18865 T18865 ROOT demonstrate,demonstrate
R15089 T18866 T18871 mark that,represents
R15090 T18867 T18871 advmod IKKβ-mediated,represents
R15091 T18868 T18870 nummod RPS3,phosphorylation
R15092 T18869 T18870 nummod S209,phosphorylation
R15093 T18870 T18871 nsubj phosphorylation,represents
R15094 T18871 T18865 ccomp represents,demonstrate
R15095 T18872 T18874 det a,determinant
R15096 T18873 T18874 amod critical,determinant
R15097 T18874 T18871 dobj determinant,represents
R15098 T18875 T18874 prep in,determinant
R15099 T18876 T18875 pcomp governing,in
R15100 T18877 T18879 poss its,import
R15101 T18878 T18879 amod nuclear,import
R15102 T18879 T18876 dobj import,governing
R15103 T18880 T18881 advmod thus,unveiling
R15104 T18881 T18871 advcl unveiling,represents
R15105 T18882 T18884 det a,mechanism
R15106 T18883 T18884 compound novel,mechanism
R15107 T18884 T18881 dobj mechanism,unveiling
R15108 T18885 T18884 prep behind,mechanism
R15109 T18886 T18888 amod NF-κB,specificity
R15110 T18887 T18888 amod regulatory,specificity
R15111 T18888 T18885 pobj specificity,behind
R15112 T18889 T18865 punct .,demonstrate
R15113 T18890 T18891 nsubj IKKβ,is
R15181 T18958 T18959 det this,phosphorylation
R15182 T18959 T18960 nsubj phosphorylation,is
R15183 T18960 T18957 ccomp is,found
R15184 T18961 T18963 det a,modulation
R15185 T18962 T18963 amod critical,modulation
R15186 T18963 T18960 attr modulation,is
R15187 T18964 T18963 prep for,modulation
R15188 T18965 T18967 nmod RPS3,translocation
R15189 T18966 T18967 amod nuclear,translocation
R15190 T18967 T18964 pobj translocation,for
R15191 T18968 T18967 punct (,translocation
R15192 T18969 T18967 prep via,translocation
R15193 T18970 T18969 pobj importin-α,via
R15194 T18971 T18967 punct ),translocation
R15195 T18972 T18967 cc and,translocation
R15196 T18973 T18963 conj engagement,modulation
R15197 T18974 T18973 prep in,engagement
R15198 T18975 T18977 amod specific,transcription
R15199 T18976 T18977 compound NF-κB,transcription
R15200 T18977 T18974 pobj transcription,in
R15201 T18978 T18957 punct .,found
R15202 T18979 T18982 nsubjpass CK2,shown
R15203 T18980 T18982 auxpass was,shown
R15204 T18981 T18982 advmod previously,shown
R15205 T18982 T18982 ROOT shown,shown
R15206 T18983 T18984 aux to,phosphorylate
R15207 T18984 T18982 xcomp phosphorylate,shown
R15208 T18985 T18984 dobj p65,phosphorylate
R15209 T18986 T18984 cc and,phosphorylate
R15210 T18987 T18988 aux to,bind
R15211 T18988 T18982 advcl bind,shown
R15212 T18989 T18988 prep to,bind
R15213 T18990 T18988 cc and,bind
R15214 T18991 T18992 compound phosphorylate,IKKβ41-43
R15215 T18992 T18988 conj IKKβ41-43,bind
R15216 T18993 T18997 punct ",",ruled
R15217 T18994 T18997 advmod however,ruled
R15218 T18995 T18997 punct ",",ruled
R15219 T18996 T18997 nsubj we,ruled
R15220 T18997 T18982 advcl ruled,shown
R15221 T18998 T18997 prt out,ruled
R15222 T18999 T19000 det the,possibility
R15223 T19000 T18997 dobj possibility,ruled
R15224 T19001 T19006 mark that,account
R15225 T19002 T19004 det the,CK2
R15226 T19003 T19004 amod IKKβ-bound,CK2
R15227 T19004 T19006 nsubj CK2,account
R15228 T19005 T19006 aux could,account
R15229 T19006 T19000 acl account,possibility
R15230 T19007 T19006 prep for,account
R15231 T19008 T19011 det the,phosphorylation
R15232 T19009 T19011 amod observed,phosphorylation
R15233 T19010 T19011 compound RPS3,phosphorylation
R15234 T19011 T19007 pobj phosphorylation,for
R15235 T19012 T19016 mark because,detected
R15236 T19013 T19014 det no,CK2
R15237 T19014 T19016 nsubjpass CK2,detected
R15313 T19090 T19082 appos H7,pathogenesis
R15314 T19091 T19064 punct .,elucidated
R15315 T19092 T19095 amod IKKβ-mediated,phosphorylation
R15316 T19093 T19095 compound RPS3,phosphorylation
R15317 T19094 T19095 compound S209,phosphorylation
R15318 T19095 T19096 nsubj phosphorylation,is
R15319 T19096 T19096 ROOT is,is
R15320 T19097 T19099 det a,target
R15321 T19098 T19099 amod critical,target
R15322 T19099 T19096 attr target,is
R15323 T19100 T19099 acl modulated,target
R15324 T19101 T19100 agent by,modulated
R15325 T19102 T19103 det this,pathogen
R15326 T19103 T19101 pobj pathogen,by
R15327 T19104 T19105 aux to,subvert
R15328 T19105 T19100 advcl subvert,modulated
R15329 T19106 T19105 dobj host,subvert
R15330 T19107 T19108 compound NF-κB,signaling
R15331 T19108 T19096 advcl signaling,is
R15332 T19109 T19096 punct .,is
R15333 T19110 T19115 det The,binds
R15334 T19111 T19112 amod bacterial,effector
R15335 T19112 T19115 nsubj effector,binds
R15336 T19113 T19112 appos NleH1,effector
R15337 T19114 T19115 advmod specifically,binds
R15338 T19115 T19119 nsubj binds,injected
R15339 T19116 T19115 prep to,binds
R15340 T19117 T19116 pobj RPS3,to
R15341 T19118 T19119 advmod once,injected
R15342 T19119 T19119 ROOT injected,injected
R15343 T19120 T19119 prep into,injected
R15344 T19121 T19122 compound host,cells
R15345 T19122 T19120 pobj cells,into
R15346 T19123 T19119 cc and,injected
R15347 T19124 T19125 advmod profoundly,suppresses
R15348 T19125 T19119 conj suppresses,injected
R15349 T19126 T19125 dobj NF-κB,suppresses
R15350 T19127 T19126 cc and,NF-κB
R15351 T19128 T19132 poss its,responses9
R15352 T19129 T19132 amod attendant,responses9
R15353 T19130 T19132 amod protective,responses9
R15354 T19131 T19132 amod immune,responses9
R15355 T19132 T19126 conj responses9,NF-κB
R15356 T19133 T19119 punct .,injected
R15357 T19134 T19135 poss Our,data
R15358 T19135 T19137 nsubj data,show
R15359 T19136 T19137 advmod now,show
R15360 T19137 T19137 ROOT show,show
R15361 T19138 T19141 mark that,inhibits
R15362 T19139 T19141 nsubj NleH1,inhibits
R15363 T19140 T19141 advmod selectively,inhibits
R15364 T19141 T19137 ccomp inhibits,show
R15365 T19142 T19143 nummod RPS3,phosphorylation
R15366 T19143 T19141 dobj phosphorylation,inhibits
R15367 T19144 T19141 punct ",",inhibits
R15114 T18891 T18891 ROOT is,is
R15115 T18892 T18894 det the,kinase
R15116 T18893 T18894 amod major,kinase
R15117 T18894 T18891 attr kinase,is
R15118 T18895 T18896 nsubj that,phosphorylates
R15119 T18896 T18894 relcl phosphorylates,kinase
R15120 T18897 T18896 dobj IκBs,phosphorylates
R15121 T18898 T18897 prep in,IκBs
R15122 T18899 T18902 det the,pathway
R15123 T18900 T18902 amod classical,pathway
R15124 T18901 T18902 compound NF-κB,pathway
R15125 T18902 T18898 pobj pathway,in
R15126 T18903 T18891 punct ",",is
R15127 T18904 T18891 advcl leading,is
R15128 T18905 T18904 prep to,leading
R15129 T18906 T18908 poss their,degradation40
R15130 T18907 T18908 amod subsequent,degradation40
R15131 T18908 T18905 pobj degradation40,to
R15132 T18909 T18891 punct .,is
R15133 T18910 T18913 advmod Strikingly,possesses
R15134 T18911 T18913 punct ",",possesses
R15135 T18912 T18913 nsubj RPS3,possesses
R15136 T18913 T18924 ccomp possesses,centered
R15137 T18914 T18913 neg not,possesses
R15138 T18915 T18918 det any,motif
R15139 T18916 T18918 compound consensus,motif
R15140 T18917 T18918 compound IKK,motif
R15141 T18918 T18913 dobj motif,possesses
R15142 T18919 T18924 punct ;,centered
R15143 T18920 T18924 advmod instead,centered
R15144 T18921 T18924 punct ",",centered
R15145 T18922 T18924 nsubjpass S209,centered
R15146 T18923 T18924 auxpass is,centered
R15147 T18924 T18924 ROOT centered,centered
R15148 T18925 T18924 prep in,centered
R15149 T18926 T18929 det a,motif
R15150 T18927 T18929 compound consensus,motif
R15151 T18928 T18929 compound CK2,motif
R15152 T18929 T18925 pobj motif,in
R15153 T18930 T18924 punct .,centered
R15154 T18931 T18933 det The,observation
R15155 T18932 T18933 amod recent,observation
R15156 T18933 T18933 ROOT observation,observation
R15157 T18934 T18937 dobj that,displayed
R15158 T18935 T18936 compound human,IKKβ
R15159 T18936 T18937 nsubj IKKβ,displayed
R15160 T18937 T18933 relcl displayed,observation
R15161 T18938 T18939 amod CK2-like,phosphorylation
R15162 T18939 T18933 appos phosphorylation,observation
R15238 T19015 T19016 auxpass was,detected
R15239 T19016 T19006 advcl detected,account
R15240 T19017 T19016 prep in,detected
R15241 T19018 T19020 det the,preparations
R15242 T19019 T19020 compound IKKβ,preparations
R15243 T19020 T19017 pobj preparations,in
R15244 T19021 T19020 acl used,preparations
R15245 T19022 T19021 prep for,used
R15246 T19023 T19027 det the,assay
R15247 T19024 T19027 nmod in,assay
R15248 T19025 T19027 amod vitro,assay
R15249 T19026 T19027 compound kinase,assay
R15250 T19027 T19022 pobj assay,for
R15251 T19028 T18982 punct .,shown
R15252 T19029 T19032 mark Because,harbors
R15253 T19030 T19032 nsubj RPS3,harbors
R15254 T19031 T19032 advmod only,harbors
R15255 T19032 T19048 advcl harbors,explain
R15256 T19033 T19035 det the,motif
R15257 T19034 T19035 compound CK2,motif
R15258 T19035 T19032 dobj motif,harbors
R15259 T19036 T19035 cc and,motif
R15260 T19037 T19041 neg not,motif
R15261 T19038 T19041 det a,motif
R15262 T19039 T19041 amod traditional,motif
R15263 T19040 T19041 compound IKK,motif
R15264 T19041 T19035 conj motif,motif
R15265 T19042 T19048 punct ",",explain
R15266 T19043 T19046 det this,function
R15267 T19044 T19046 amod RPS3,function
R15268 T19045 T19046 amod regulatory,function
R15269 T19046 T19048 nsubj function,explain
R15270 T19047 T19048 aux could,explain
R15271 T19048 T19048 ROOT explain,explain
R15272 T19049 T19051 advmod why,harbors
R15273 T19050 T19051 nsubj IKK,harbors
R15274 T19051 T19048 ccomp harbors,explain
R15275 T19052 T19056 det the,capability
R15276 T19053 T19056 amod alternative,capability
R15277 T19054 T19056 compound substrate,capability
R15278 T19055 T19056 compound phosphorylation,capability
R15279 T19056 T19051 dobj capability,harbors
R15280 T19057 T19048 punct .,explain
R15281 T19058 T19059 advmod More,importantly
R15282 T19059 T19064 advmod importantly,elucidated
R15283 T19060 T19064 punct ",",elucidated
R15284 T19061 T19062 poss our,study
R15285 T19062 T19064 nsubj study,elucidated
R15286 T19063 T19064 aux has,elucidated
R15287 T19064 T19064 ROOT elucidated,elucidated
R15288 T19065 T19069 advmod how,integrated
R15289 T19066 T19069 nsubjpass RPS3,integrated
R15290 T19067 T19069 auxpass is,integrated
R15291 T19068 T19069 advmod biochemically,integrated
R15292 T19069 T19064 ccomp integrated,elucidated
R15293 T19070 T19069 prep into,integrated
R15294 T19071 T19072 amod NF-κB,activation
R15295 T19072 T19070 pobj activation,into
R15296 T19073 T19069 advcl signaling,integrated
R15297 T19074 T19073 prep in,signaling
R15298 T19075 T19076 det a,manner
R15299 T19076 T19074 pobj manner,in
R15300 T19077 T19078 nsubj that,is
R15301 T19078 T19076 relcl is,manner
R15302 T19079 T19078 acomp pivotal,is
R15303 T19080 T19079 prep for,pivotal
R15304 T19081 T19082 det the,pathogenesis
R15305 T19082 T19080 pobj pathogenesis,for
R15306 T19083 T19082 prep of,pathogenesis
R15307 T19084 T19087 compound foodborne,coli
R15308 T19085 T19087 compound pathogen,coli
R15309 T19086 T19087 compound E.,coli
R15310 T19087 T19088 compound coli,O157
R15311 T19088 T19083 pobj O157,of
R15312 T19089 T19082 punct :,pathogenesis
R15388 T19165 T19166 advmod directly,phosphorylate
R15389 T19166 T19173 advcl phosphorylate,required
R15390 T19167 T19166 dobj IKKβ,phosphorylate
R15391 T19168 T19173 punct ",",required
R15392 T19169 T19171 poss its,activity
R15393 T19170 T19171 compound kinase,activity
R15394 T19171 T19173 nsubjpass activity,required
R15395 T19172 T19173 auxpass was,required
R15396 T19173 T19173 ROOT required,required
R15397 T19174 T19175 aux to,inhibit
R15398 T19175 T19173 advcl inhibit,required
R15399 T19176 T19179 amod IKKβ-mediated,phosphorylation
R15400 T19177 T19179 compound RPS3,phosphorylation
R15401 T19178 T19179 compound S209,phosphorylation
R15402 T19179 T19175 dobj phosphorylation,inhibit
R15403 T19180 T19173 punct .,required
R15404 T19181 T19182 amod Many,bacteria
R15405 T19182 T19183 compound bacteria,pathogens
R15406 T19183 T19184 nsubj pathogens,have
R15407 T19184 T19184 ROOT have,have
R15408 T19185 T19184 dobj products,have
R15409 T19186 T19187 nsubj that,target
R15410 T19187 T19185 relcl target,products
R15411 T19188 T19189 amod key,kinases
R15412 T19189 T19187 dobj kinases,target
R15413 T19190 T19191 aux to,inactivate
R15414 T19191 T19187 advcl inactivate,target
R15415 T19192 T19191 dobj them,inactivate
R15416 T19193 T19191 prep in,inactivate
R15417 T19194 T19195 compound host,cells
R15418 T19195 T19193 pobj cells,in
R15419 T19196 T19184 punct ",",have
R15420 T19197 T19203 mark whereas,employed
R15421 T19198 T19200 compound E.,O157
R15368 T19145 T19146 advmod thus,retarding
R15369 T19146 T19141 advcl retarding,inhibits
R15370 T19147 T19149 poss its,translocation
R15371 T19148 T19149 amod nuclear,translocation
R15372 T19149 T19146 dobj translocation,retarding
R15373 T19150 T19149 cc and,translocation
R15374 T19151 T19153 amod subsequent,function
R15375 T19152 T19153 compound NF-κB,function
R15376 T19153 T19149 conj function,translocation
R15377 T19154 T19146 punct ",",retarding
R15378 T19155 T19146 prep without,retarding
R15379 T19156 T19155 pcomp altering,without
R15380 T19157 T19159 amod other,signaling
R15381 T19158 T19159 amod NF-κB,signaling
R15382 T19159 T19141 advcl signaling,inhibits
R15383 T19160 T19137 punct .,show
R15384 T19161 T19166 mark Although,phosphorylate
R15385 T19162 T19166 nsubj NleH1,phosphorylate
R15386 T19163 T19166 aux did,phosphorylate
R15387 T19164 T19166 neg not,phosphorylate
R15463 T19240 T19240 ROOT provide,provide
R15464 T19241 T19242 amod new,insights
R15465 T19242 T19240 dobj insights,provide
R15466 T19243 T19242 prep into,insights
R15467 T19244 T19248 det the,mechanism
R15468 T19245 T19246 advmod poorly,understood
R15469 T19246 T19248 amod understood,mechanism
R15470 T19247 T19248 compound action,mechanism
R15471 T19248 T19243 pobj mechanism,into
R15472 T19249 T19240 prep for,provide
R15473 T19250 T19252 amod most,effectors
R15474 T19251 T19252 nummod T3SS,effectors
R15475 T19252 T19249 pobj effectors,for
R15476 T19253 T19240 punct .,provide
R15477 T19254 T19255 nummod NleH1,attenuates
R15478 T19255 T19255 ROOT attenuates,attenuates
R15479 T19256 T19257 det the,transcription
R15480 T19257 T19255 dobj transcription,attenuates
R15481 T19258 T19257 prep of,transcription
R15482 T19259 T19258 pobj RPS3-dependent,of
R15483 T19260 T19255 punct ",",attenuates
R15484 T19261 T19255 cc but,attenuates
R15485 T19262 T19263 neg not,all
R15486 T19263 T19255 conj all,attenuates
R15487 T19264 T19267 punct ",",genes
R15488 T19265 T19267 amod NF-κB,genes
R15489 T19266 T19267 compound target,genes
R15490 T19267 T19255 conj genes,attenuates
R15491 T19268 T19267 punct ",",genes
R15492 T19269 T19272 prep in,genes
R15493 T19270 T19269 amod particular,in
R15494 T19271 T19272 det those,genes
R15495 T19272 T19267 conj genes,genes
R15496 T19273 T19272 acl associated,genes
R15497 T19274 T19273 prep with,associated
R15498 T19275 T19277 amod acute,responses
R15499 T19276 T19277 amod proinflammatory,responses
R15500 T19277 T19274 pobj responses,with
R15501 T19278 T19277 punct ",",responses
R15502 T19279 T19277 prep including,responses
R15503 T19280 T19279 pobj IL8,including
R15504 T19281 T19280 cc and,IL8
R15505 T19282 T19280 conj TNF,IL8
R15506 T19283 T19255 punct .,attenuates
R15507 T19284 T19290 prep In,block
R15508 T19285 T19284 pobj contrast,In
R15509 T19286 T19290 punct ",",block
R15510 T19287 T19290 nsubj NleH1,block
R15511 T19288 T19290 aux does,block
R15512 T19289 T19290 neg not,block
R15513 T19290 T19290 ROOT block,block
R15514 T19291 T19294 nmod NF-κB,translocation
R15515 T19292 T19291 nummod p65,NF-κB
R15516 T19293 T19294 amod nuclear,translocation
R15517 T19294 T19290 dobj translocation,block
R15518 T19295 T19294 punct ",",translocation
R15519 T19296 T19297 nsubj which,suggests
R15520 T19297 T19294 relcl suggests,translocation
R15521 T19298 T19308 mark that,be
R15522 T19299 T19305 amod certain,genes
R15523 T19300 T19304 nmod p65-dependent,target
R15524 T19301 T19300 cc but,p65-dependent
R15525 T19302 T19300 conj RPS3-independent,p65-dependent
R15526 T19303 T19304 compound NF-κB,target
R15527 T19304 T19305 compound target,genes
R15528 T19305 T19308 nsubj genes,be
R15529 T19306 T19308 aux might,be
R15530 T19307 T19308 advmod thus,be
R15531 T19308 T19297 ccomp be,suggests
R15532 T19309 T19308 acomp beneficial,be
R15533 T19310 T19309 prep for,beneficial
R15534 T19311 T19313 compound E.,O157
R15535 T19312 T19313 compound coli,O157
R15536 T19313 T19310 pobj O157,for
R15537 T19314 T19294 punct :,translocation
R16114 T20213 T20224 nsubj Cells,were
R16115 T20214 T20213 cc and,Cells
R16116 T20215 T20223 nmod Reagents,cells
R16117 T20216 T20217 compound Jurkat,E6
R16118 T20217 T20215 dobj E6,Reagents
R16119 T20218 T20217 appos .1,E6
R16120 T20219 T20217 punct ",",E6
R16121 T20220 T20217 appos HEK293T,E6
R16122 T20221 T20217 cc and,E6
R16123 T20222 T20217 conj HeLa,E6
R16124 T20223 T20213 conj cells,Cells
R16125 T20224 T20224 ROOT were,were
R16126 T20225 T20224 acomp cultured,were
R16127 T20226 T20225 prep in,cultured
R16128 T20227 T20228 compound RPMI,1640
R16129 T20228 T20226 pobj 1640,in
R16130 T20229 T20224 cc and,were
R16131 T20230 T20231 nsubj DMEM,supplemented
R16132 T20231 T20224 conj supplemented,were
R16133 T20232 T20231 prep with,supplemented
R16134 T20233 T20234 nummod 10,%
R16135 T20234 T20237 compound %,serum
R16136 T20235 T20236 amod fetal,calf
R15422 T19199 T19200 compound coli,O157
R15423 T19200 T19203 nsubj O157,employed
R15424 T19201 T19200 punct :,O157
R15425 T19202 T19203 nsubj H7,employed
R15426 T19203 T19184 advcl employed,have
R15427 T19204 T19203 dobj NleH1,employed
R15428 T19205 T19206 aux to,steer
R15429 T19206 T19203 advcl steer,employed
R15430 T19207 T19209 det the,specificity
R15431 T19208 T19209 compound substrate,specificity
R15432 T19209 T19206 dobj specificity,steer
R15433 T19210 T19209 prep of,specificity
R15434 T19211 T19210 pobj IKKβ,of
R15435 T19212 T19214 advmod thus,fine-tuning
R15436 T19213 T19214 advmod specifically,fine-tuning
R15437 T19214 T19215 advmod fine-tuning,host
R15438 T19215 T19217 dep host,signaling
R15439 T19216 T19217 compound NF-κB,signaling
R15440 T19217 T19203 advcl signaling,employed
R15441 T19218 T19184 punct .,have
R15442 T19219 T19221 nsubj This,represent
R15443 T19220 T19221 aux could,represent
R15444 T19221 T19221 ROOT represent,represent
R15445 T19222 T19224 det a,strategy
R15446 T19223 T19224 compound novel,strategy
R15447 T19224 T19221 dobj strategy,represent
R15448 T19225 T19226 aux to,fine-tune
R15449 T19226 T19224 acl fine-tune,strategy
R15450 T19227 T19228 compound host,NF-κB
R15451 T19228 T19226 dobj NF-κB,fine-tune
R15452 T19229 T19221 advcl signaling,represent
R15453 T19230 T19233 nsubjpass that,shared
R15454 T19231 T19233 aux could,shared
R15455 T19232 T19233 auxpass be,shared
R15456 T19233 T19229 ccomp shared,signaling
R15457 T19234 T19233 agent by,shared
R15458 T19235 T19236 amod other,pathogens
R15459 T19236 T19234 pobj pathogens,by
R15460 T19237 T19221 punct .,represent
R15461 T19238 T19239 det These,data
R15462 T19239 T19240 nsubj data,provide
R15538 T19315 T19294 appos H7,translocation
R15539 T19316 T19317 aux to,replicate
R15540 T19317 T19290 advcl replicate,block
R15541 T19318 T19317 cc and,replicate
R15542 T19319 T19317 conj disseminate,replicate
R15543 T19320 T19319 prep in,disseminate
R15544 T19321 T19322 det the,host
R15545 T19322 T19320 pobj host,in
R15546 T19323 T19290 punct .,block
R15547 T19324 T19338 prep By,achieves
R15548 T19325 T19326 advmod selectively,inhibiting
R15549 T19326 T19324 pcomp inhibiting,By
R15550 T19327 T19326 dobj RPS3,inhibiting
R15551 T19328 T19327 cc and,RPS3
R15552 T19329 T19332 poss its,function
R15553 T19330 T19332 amod attendant,function
R15554 T19331 T19332 compound NF-κB,function
R15555 T19332 T19327 conj function,RPS3
R15556 T19333 T19326 prep with,inhibiting
R15557 T19334 T19333 pobj NleH1,with
R15558 T19335 T19338 punct ",",achieves
R15559 T19336 T19337 det the,pathogen
R15560 T19337 T19338 nsubj pathogen,achieves
R15561 T19338 T19338 ROOT achieves,achieves
R15562 T19339 T19340 det the,ability
R15563 T19340 T19338 dobj ability,achieves
R15564 T19341 T19342 aux to,increase
R15565 T19342 T19340 acl increase,ability
R15566 T19343 T19342 dobj colonization,increase
R15567 T19344 T19343 cc and,colonization
R15568 T19345 T19343 conj diarrhea,colonization
R15569 T19346 T19347 advmod yet,limiting
R15570 T19347 T19338 advcl limiting,achieves
R15571 T19348 T19349 det the,mortality
R15572 T19349 T19347 dobj mortality,limiting
R15573 T19350 T19349 prep of,mortality
R15574 T19351 T19352 det the,host
R15575 T19352 T19350 pobj host,of
R15576 T19353 T19338 punct .,achieves
R15577 T19354 T19357 det This,combination
R15578 T19355 T19356 advmod seemingly,paradoxical
R15579 T19356 T19357 amod paradoxical,combination
R15580 T19357 T19360 nsubj combination,make
R15581 T19358 T19357 prep of,combination
R15582 T19359 T19358 pobj effects,of
R15583 T19360 T19360 ROOT make,make
R15584 T19361 T19360 dobj sense,make
R15585 T19362 T19364 advmod when,considers
R15586 T19363 T19364 nsubj one,considers
R15587 T19364 T19360 advcl considers,make
R15588 T19365 T19379 mark that,promote
R15589 T19366 T19368 amod increased,load
R15590 T19367 T19368 amod bacterial,load
R15591 T19368 T19379 nsubj load,promote
R15592 T19369 T19368 cc and,load
R15593 T19370 T19368 conj diarrhea,load
R15594 T19371 T19372 advmod together,with
R15595 T19372 T19368 prep with,load
R15596 T19373 T19372 pobj survival,with
R15597 T19374 T19373 prep of,survival
R15598 T19375 T19377 det the,host
R15599 T19376 T19377 amod infected,host
R15600 T19377 T19374 pobj host,of
R15601 T19378 T19379 aux would,promote
R15602 T19379 T19364 ccomp promote,considers
R15603 T19380 T19381 det the,spreading
R15604 T19381 T19379 dobj spreading,promote
R15605 T19382 T19381 prep of,spreading
R15606 T19383 T19384 det the,bacteria
R15607 T19384 T19382 pobj bacteria,of
R15608 T19385 T19381 prep among,spreading
R15609 T19386 T19387 det a,population
R15610 T19387 T19385 pobj population,among
R15611 T19388 T19387 prep of,population
R15612 T19389 T19390 amod susceptible,individuals
R15613 T19390 T19388 pobj individuals,of
R15614 T19391 T19360 punct .,make
R15615 T19392 T19393 amod Such,complex
R15616 T19393 T19404 nsubj complex,are
R15617 T19394 T19393 cc and,complex
R15618 T19395 T19397 amod paradoxical,effects
R15619 T19396 T19397 amod pathological,effects
R15620 T19397 T19393 conj effects,complex
R15649 T19426 T19425 dobj RPS3,impeding
R15650 T19427 T19417 punct ",",alterations
R15651 T19428 T19417 cc but,alterations
R15652 T19429 T19430 neg not,altering
R15653 T19430 T19436 advcl altering,influence
R15654 T19431 T19433 nummod p65,translocation
R15655 T19432 T19433 amod nuclear,translocation
R15656 T19433 T19430 dobj translocation,altering
R15657 T19434 T19436 punct ",",influence
R15658 T19435 T19436 aux can,influence
R15659 T19436 T19415 ccomp influence,elucidate
R15660 T19437 T19438 amod specific,cytokines
R15661 T19438 T19436 dobj cytokines,influence
R15662 T19439 T19440 nsubj that,affect
R15663 T19440 T19438 relcl affect,cytokines
R15664 T19441 T19442 amod bacterial,colonization
R15665 T19442 T19440 dobj colonization,affect
R15666 T19443 T19442 punct ",",colonization
R15667 T19444 T19445 compound diarrhea,diseases
R15668 T19445 T19442 conj diseases,colonization
R15669 T19446 T19445 cc and,diseases
R15670 T19447 T19445 conj mortality,diseases
R15671 T19448 T19415 punct .,elucidate
R15672 T19449 T19451 nsubj It,be
R15673 T19450 T19451 aux may,be
R15674 T19451 T19451 ROOT be,be
R15675 T19452 T19451 acomp fruitful,be
R15676 T19453 T19451 prep in,be
R15677 T19454 T19453 pcomp attempting,in
R15678 T19455 T19456 aux to,understand
R15679 T19456 T19454 xcomp understand,attempting
R15680 T19457 T19461 amod other,diseases
R15681 T19458 T19461 amod infectious,diseases
R15682 T19459 T19458 cc and,infectious
R16137 T20236 T20237 compound calf,serum
R16138 T20237 T20232 pobj serum,with
R16139 T20238 T20237 punct ",",serum
R16140 T20239 T20241 nummod 2,glutamine
R16141 T20240 T20241 compound mM,glutamine
R16142 T20241 T20237 conj glutamine,serum
R16143 T20242 T20241 punct ",",glutamine
R16144 T20243 T20241 cc and,glutamine
R16145 T20244 T20245 nummod 100,U/ml
R16146 T20245 T20241 conj U/ml,glutamine
R16147 T20246 T20245 npadvmod each,U/ml
R16148 T20247 T20246 prep of,each
R16149 T20248 T20247 pobj penicillin,of
R16150 T20249 T20248 cc and,penicillin
R16151 T20250 T20248 conj streptomycin,penicillin
R16152 T20251 T20246 punct ",",each
R16153 T20252 T20246 conj respectively,each
R16154 T20253 T20231 punct .,supplemented
R16155 T20254 T20256 nmod IκBα,C-21
R16156 T20255 T20256 punct (,C-21
R16157 T20256 T20276 nsubj C-21,were
R16158 T20257 T20256 punct ",",C-21
R16159 T20258 T20256 amod sc-371,C-21
R16160 T20259 T20258 punct ),sc-371
R16161 T20260 T20256 punct ",",C-21
R16162 T20261 T20256 conj p65,C-21
R16163 T20262 T20261 punct (,p65
R16239 T20338 T20337 punct (,IKKβ
R16240 T20339 T20337 appos 24,IKKβ
R16241 T20340 T20337 punct ",",IKKβ
R16242 T20341 T20337 appos 611254,IKKβ
R16243 T20342 T20337 punct ),IKKβ
R16244 T20343 T20344 nsubj antibodies,were
R16245 T20344 T20363 ccomp were,were
R16246 T20345 T20344 prep from,were
R16247 T20346 T20347 compound BD,Pharmingen
R16248 T20347 T20345 pobj Pharmingen,from
R16249 T20348 T20363 punct ;,were
R16250 T20349 T20363 nsubj CK2α,were
R16251 T20350 T20351 punct (,31
R16252 T20351 T20349 nummod 31,CK2α
R16253 T20352 T20349 punct ",",CK2α
R16254 T20353 T20349 appos 611610,CK2α
R16255 T20354 T20349 punct ),CK2α
R16256 T20355 T20349 cc and,CK2α
R16257 T20356 T20349 conj Hsp90,CK2α
R16258 T20357 T20356 punct (,Hsp90
R16259 T20358 T20356 appos 68,Hsp90
R16260 T20359 T20356 punct ",",Hsp90
R16261 T20360 T20356 appos 610418,Hsp90
R16262 T20361 T20356 punct ),Hsp90
R16263 T20362 T20363 nsubj antibodies,were
R16264 T20363 T20385 ccomp were,were
R16265 T20364 T20363 prep from,were
R16266 T20365 T20367 compound BD,Laboratories
R16267 T20366 T20367 compound Transduction,Laboratories
R16268 T20367 T20364 pobj Laboratories,from
R16269 T20368 T20385 punct ;,were
R16270 T20369 T20385 nsubj phospho-IκBα,were
R16271 T20370 T20371 punct (,5A5
R16272 T20371 T20369 appos 5A5,phospho-IκBα
R16273 T20372 T20371 punct ",",5A5
R16274 T20373 T20371 appos 9246S,5A5
R16275 T20374 T20371 punct ),5A5
R16276 T20375 T20371 cc and,5A5
R16277 T20376 T20378 amod phospho-IKKα,β
R16278 T20377 T20378 compound /,β
R16279 T20378 T20369 conj β,phospho-IκBα
R16280 T20379 T20380 punct (,16A6
R16281 T20380 T20378 appos 16A6,β
R16282 T20381 T20380 punct ",",16A6
R16283 T20382 T20380 appos 2697S,16A6
R16284 T20383 T20380 punct ),16A6
R16285 T20384 T20385 nsubj antibodies,were
R16286 T20385 T20403 ccomp were,were
R16287 T20386 T20385 prep from,were
R16288 T20387 T20389 compound Cell,Technology
R16289 T20388 T20389 compound Signaling,Technology
R16290 T20389 T20386 pobj Technology,from
R16291 T20390 T20403 punct ;,were
R16292 T20391 T20402 nmod phospho-serine,antibodies
R16293 T20392 T20393 punct (,AB1603
R16294 T20393 T20391 appos AB1603,phospho-serine
R16295 T20394 T20393 punct ),AB1603
R16296 T20395 T20391 cc and,phospho-serine
R16297 T20396 T20391 conj phospho-tyrosine,phospho-serine
R16298 T20397 T20398 punct (,4G10
R16299 T20398 T20402 nmod 4G10,antibodies
R16300 T20399 T20398 punct ",",4G10
R16301 T20400 T20398 appos 05-777,4G10
R16302 T20401 T20398 punct ),4G10
R16303 T20402 T20403 nsubj antibodies,were
R16304 T20403 T20403 ROOT were,were
R16305 T20404 T20403 prep from,were
R16306 T20405 T20404 pobj Millipore,from
R16307 T20406 T20403 punct .,were
R16308 T20407 T20411 det The,antiserum
R16309 T20408 T20411 nmod rabbit,antiserum
R16310 T20409 T20411 compound polyclonal,antiserum
R16311 T20410 T20411 compound RPS3,antiserum
R16312 T20411 T20412 nsubj antiserum,was
R16313 T20412 T20412 ROOT was,was
R16464 T20647 T20643 punct ",",Flag-IKKβ
R16465 T20648 T20643 cc and,Flag-IKKβ
R16466 T20649 T20643 conj HA-IκBα,Flag-IKKβ
R16467 T20650 T20651 punct (,SSAA
R16468 T20651 T20649 appos SSAA,HA-IκBα
R16469 T20652 T20649 punct ),HA-IκBα
R16470 T20653 T20655 nsubjpass constructs,provided
R16471 T20654 T20655 auxpass were,provided
R16472 T20655 T20655 ROOT provided,provided
R16473 T20656 T20655 agent by,provided
R16474 T20657 T20658 compound C.,Wu
R16475 T20658 T20656 pobj Wu,by
R16476 T20659 T20660 punct (,NCI
R16477 T20660 T20658 appos NCI,Wu
R16478 T20661 T20660 punct ",",NCI
R16479 T20662 T20660 npadvmod Bethesda,NCI
R16480 T20663 T20660 punct ),NCI
R16481 T20664 T20658 cc and,Wu
R16482 T20665 T20666 compound U.,Siebenlist
R15683 T19460 T19458 conj autoimmune,infectious
R15684 T19461 T19456 dobj diseases,understand
R15685 T19462 T19461 acl involving,diseases
R15686 T19463 T19462 dobj NF-κB,involving
R15687 T19464 T19465 aux to,consider
R15688 T19465 T19456 advcl consider,understand
R15689 T19466 T19467 amod selective,effects
R15690 T19467 T19465 dobj effects,consider
R15691 T19468 T19467 prep of,effects
R15692 T19469 T19468 pobj subunits,of
R15693 T19470 T19471 amod such,as
R15694 T19471 T19469 prep as,subunits
R15695 T19472 T19471 pobj RPS3,as
R15696 T19473 T19465 prep in,consider
R15697 T19474 T19473 pobj addition,in
R15698 T19475 T19474 prep to,addition
R15699 T19476 T19478 amod global,inhibition
R15700 T19477 T19478 compound NF-κB,inhibition
R15701 T19478 T19475 pobj inhibition,to
R15702 T19479 T19451 punct .,be
R16164 T20263 T20271 nmod C-20,H-2
R16165 T20264 T20263 punct ",",C-20
R16166 T20265 T20263 conj sc-372,C-20
R16167 T20266 T20265 punct ),sc-372
R16168 T20267 T20263 punct ",",C-20
R16169 T20268 T20263 cc and,C-20
R16170 T20269 T20263 conj phospho-threonine,C-20
R16171 T20270 T20271 punct (,H-2
R16172 T20271 T20261 appos H-2,p65
R16173 T20272 T20271 punct ",",H-2
R16174 T20273 T20271 conj sc-5267,H-2
R16175 T20274 T20273 punct ),sc-5267
R16176 T20275 T20271 conj antibodies,H-2
R16177 T20276 T20318 ccomp were,were
R16178 T20277 T20276 prep from,were
R16179 T20278 T20279 compound Santa,Cruz
R16180 T20279 T20280 compound Cruz,Biotechnology
R16181 T20280 T20277 pobj Biotechnology,from
R16182 T20281 T20318 punct ;,were
R16183 T20282 T20318 nsubj β-actin,were
R16184 T20283 T20284 punct (,AC-15
R16185 T20284 T20282 appos AC-15,β-actin
R16186 T20285 T20284 punct ",",AC-15
R16187 T20286 T20284 appos A5441,AC-15
R16188 T20287 T20284 punct ),AC-15
R16189 T20288 T20284 punct ",",AC-15
R16190 T20289 T20298 nmod Flag,HA-7
R16191 T20290 T20291 punct (,M2
R16192 T20291 T20289 appos M2,Flag
R16193 T20292 T20291 punct ",",M2
R16194 T20293 T20291 appos F3165,M2
R16195 T20294 T20291 punct ),M2
R16196 T20295 T20289 punct ",",Flag
R16197 T20296 T20298 nmod HA,HA-7
R16198 T20297 T20298 punct (,HA-7
R16199 T20298 T20284 conj HA-7,AC-15
R16200 T20299 T20298 punct ",",HA-7
R16201 T20300 T20298 conj H3663,HA-7
R16202 T20301 T20298 punct ),HA-7
R16203 T20302 T20298 punct ",",HA-7
R16204 T20303 T20298 conj importin-α,HA-7
R16205 T20304 T20305 punct (,IM-75
R16206 T20305 T20303 appos IM-75,importin-α
R16207 T20306 T20305 punct ",",IM-75
R16208 T20307 T20305 appos I1784,IM-75
R16209 T20308 T20305 punct ),IM-75
R16210 T20309 T20305 punct ",",IM-75
R16211 T20310 T20303 cc and,importin-α
R16212 T20311 T20303 conj importin-β,importin-α
R16213 T20312 T20317 punct (,antibodies
R16214 T20313 T20317 nmod 31H4,antibodies
R16215 T20314 T20313 punct ",",31H4
R16216 T20315 T20313 conj I2534,31H4
R16217 T20316 T20317 punct ),antibodies
R16218 T20317 T20284 appos antibodies,AC-15
R16219 T20318 T20344 ccomp were,were
R16220 T20319 T20318 prep from,were
R16221 T20320 T20319 pobj Sigma,from
R16222 T20321 T20344 punct ;,were
R16223 T20322 T20343 compound PARP,antibodies
R16224 T20323 T20324 punct (,C2-10
R16225 T20324 T20322 appos C2-10,PARP
R16226 T20325 T20324 punct ",",C2-10
R16227 T20326 T20324 appos 556362,C2-10
R16228 T20327 T20324 punct ),C2-10
R16229 T20328 T20324 punct ",",C2-10
R16230 T20329 T20324 conj IKKα,C2-10
R16231 T20330 T20331 punct (,B78-1
R16232 T20331 T20329 appos B78-1,IKKα
R16233 T20332 T20331 punct ",",B78-1
R16234 T20333 T20331 appos 556532,B78-1
R16235 T20334 T20331 punct ),B78-1
R16236 T20335 T20329 punct ",",IKKα
R16237 T20336 T20329 cc and,IKKα
R16238 T20337 T20329 conj IKKβ,IKKα
R16314 T20413 T20414 mark as,described
R16315 T20414 T20415 amod described,previously6
R16316 T20415 T20412 attr previously6,was
R16317 T20416 T20412 punct .,was
R16318 T20417 T20421 det The,specific
R16319 T20418 T20420 nmod rabbit,antibody
R16320 T20419 T20420 compound polyclonal,antibody
R16321 T20420 T20421 compound antibody,specific
R16322 T20421 T20424 nsubj specific,phosphorylated
R16323 T20422 T20421 prep for,specific
R16324 T20423 T20422 pobj S209,for
R16325 T20424 T20424 ROOT phosphorylated,phosphorylated
R16326 T20425 T20427 nsubjpass RPS3,generated
R16327 T20426 T20427 auxpass was,generated
R16328 T20427 T20424 ccomp generated,phosphorylated
R16329 T20428 T20427 cc and,generated
R16330 T20429 T20427 conj affinity,generated
R16331 T20430 T20429 acl purified,affinity
R16332 T20431 T20430 agent by,purified
R16333 T20432 T20433 compound Primm,Biotech
R16334 T20433 T20431 pobj Biotech,by
R16335 T20434 T20429 conj using,affinity
R16336 T20435 T20437 det the,NH2-CKPLPDHV
R16337 T20436 T20437 compound peptide,NH2-CKPLPDHV
R16338 T20437 T20434 dobj NH2-CKPLPDHV,using
R16339 T20438 T20437 punct (,NH2-CKPLPDHV
R16340 T20439 T20441 nmod Sp,IVE-COOH
R16341 T20440 T20441 punct ),IVE-COOH
R16342 T20441 T20437 appos IVE-COOH,NH2-CKPLPDHV
R16343 T20442 T20424 punct .,phosphorylated
R16452 T20635 T20636 amod Plasmid,Constructs
R16453 T20636 T20653 nmod Constructs,constructs
R16454 T20637 T20638 det The,Flag-IKKβ
R16455 T20638 T20653 nmod Flag-IKKβ,constructs
R16456 T20639 T20640 punct (,SSEE
R16457 T20640 T20638 appos SSEE,Flag-IKKβ
R16458 T20641 T20640 punct ),SSEE
R16459 T20642 T20638 punct ",",Flag-IKKβ
R16460 T20643 T20638 conj Flag-IKKβ,Flag-IKKβ
R16461 T20644 T20645 punct (,SSAA
R16462 T20645 T20643 appos SSAA,Flag-IKKβ
R16463 T20646 T20643 punct ),Flag-IKKβ
R16539 T20722 T20723 compound Change,Kit
R16540 T20723 T20719 dobj Kit,using
R16541 T20724 T20723 punct (,Kit
R16542 T20725 T20723 appos Stratagene,Kit
R16543 T20726 T20723 punct ),Kit
R16544 T20727 T20719 prep with,using
R16545 T20728 T20727 pobj primers,with
R16546 T20729 T20719 advmod forward,using
R16547 T20730 T20734 nummod 5,′
R16548 T20731 T20733 punct ′,CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3
R16549 T20732 T20733 punct -,CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3
R16550 T20733 T20734 compound CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3,′
R16551 T20734 T20719 dobj ′,using
R16552 T20735 T20715 cc and,generated
R16553 T20736 T20715 conj reverse,generated
R16554 T20737 T20740 nummod 5,TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3
R16555 T20738 T20740 punct ′,TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3
R16556 T20739 T20740 punct -,TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3
R16557 T20740 T20741 compound TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3,′
R16558 T20741 T20736 dobj ′,reverse
R16559 T20742 T20741 prep for,′
R16483 T20666 T20658 conj Siebenlist,Wu
R16484 T20667 T20668 punct (,NIAID
R16485 T20668 T20666 appos NIAID,Siebenlist
R16486 T20669 T20668 punct ",",NIAID
R16487 T20670 T20668 npadvmod Bethesda,NIAID
R16488 T20671 T20668 punct ),NIAID
R16489 T20672 T20666 punct ",",Siebenlist
R16490 T20673 T20666 advmod respectively,Siebenlist
R16491 T20674 T20655 punct .,provided
R16492 T20675 T20676 det The,HA-IκBα
R16493 T20676 T20684 nmod HA-IκBα,plasmids
R16494 T20677 T20676 cc and,HA-IκBα
R16495 T20678 T20676 conj IKKβ,HA-IκBα
R16496 T20679 T20678 punct (,IKKβ
R16497 T20680 T20678 appos K44A,IKKβ
R16498 T20681 T20678 punct ),IKKβ
R16499 T20682 T20678 punct -,IKKβ
R16500 T20683 T20684 compound Flag,plasmids
R16501 T20684 T20686 nsubjpass plasmids,purchased
R16502 T20685 T20686 auxpass were,purchased
R16503 T20686 T20686 ROOT purchased,purchased
R16504 T20687 T20686 prep from,purchased
R16505 T20688 T20687 pobj Addgene44,from
R16506 T20689 T20688 punct ",",Addgene44
R16507 T20690 T20688 appos 45,Addgene44
R16508 T20691 T20686 punct .,purchased
R16509 T20692 T20693 det The,Flag-RPS3
R16510 T20693 T20704 nsubjpass Flag-RPS3,described
R16511 T20694 T20693 punct ",",Flag-RPS3
R16512 T20695 T20693 appos GST-RPS3,Flag-RPS3
R16513 T20696 T20695 punct ",",GST-RPS3
R16514 T20697 T20695 conj HA-RPS3,GST-RPS3
R16515 T20698 T20697 punct ",",HA-RPS3
R16516 T20699 T20697 conj VN-HA,HA-RPS3
R16517 T20700 T20699 punct ",",VN-HA
R16518 T20701 T20702 compound NleH1-HA,plasmids
R16519 T20702 T20704 nsubjpass plasmids,described
R16520 T20703 T20704 auxpass were,described
R16521 T20704 T20704 ROOT described,described
R16522 T20705 T20704 dobj previously6,described
R16523 T20706 T20705 punct ",",previously6
R16524 T20707 T20705 conj 9,previously6
R16525 T20708 T20704 punct .,described
R16526 T20709 T20711 det The,mutants
R16527 T20710 T20711 compound point,mutants
R16528 T20711 T20715 nsubjpass mutants,generated
R16529 T20712 T20711 prep of,mutants
R16530 T20713 T20712 pobj RPS3,of
R16531 T20714 T20715 auxpass were,generated
R16532 T20715 T20715 ROOT generated,generated
R16533 T20716 T20715 agent by,generated
R16534 T20717 T20718 amod site-directed,mutagenesis
R16535 T20718 T20716 pobj mutagenesis,by
R16536 T20719 T20715 advcl using,generated
R16537 T20720 T20723 det the,Kit
R16538 T20721 T20723 compound Quick,Kit
R16841 T21164 T21166 nsubjpass proteins,purchased
R16842 T21165 T21166 auxpass were,purchased
R16843 T21166 T21166 ROOT purchased,purchased
R16844 T21167 T21166 prep from,purchased
R16845 T21168 T21169 compound Active,Motif
R16846 T21169 T21167 pobj Motif,from
R16847 T21170 T21169 cc and,Motif
R16848 T21171 T21169 conj Millipore,Motif
R16849 T21172 T21166 punct ",",purchased
R16850 T21173 T21166 advmod respectively,purchased
R16851 T21174 T21166 punct .,purchased
R16852 T21175 T21178 advmod Bacterially,S-transferase
R16853 T21176 T21178 amod purified,S-transferase
R16854 T21177 T21178 compound glutathione,S-transferase
R16855 T21178 T21198 nsubjpass S-transferase,used
R16856 T21179 T21180 punct (,GST
R16857 T21180 T21178 appos GST,S-transferase
R16858 T21181 T21180 punct ),GST
R16859 T21182 T21178 punct ",",S-transferase
R16860 T21183 T21178 appos GST-IκBα,S-transferase
R16861 T21184 T21185 punct (,1-54
R16862 T21185 T21183 parataxis 1-54,GST-IκBα
R16863 T21186 T21183 punct ),GST-IκBα
R16864 T21187 T21178 punct ",",S-transferase
R16865 T21188 T21189 amod wild,type
R16866 T21189 T21178 conj type,S-transferase
R16867 T21190 T21189 punct ",",type
R16868 T21191 T21192 amod mutant,GST-RPS3
R16869 T21192 T21189 conj GST-RPS3,type
R16870 T21193 T21192 punct ",",GST-RPS3
R16871 T21194 T21192 cc or,GST-RPS3
R16872 T21195 T21196 nummod RPS3,proteins
R16873 T21196 T21192 conj proteins,GST-RPS3
R16874 T21197 T21198 auxpass were,used
R16875 T21198 T21198 ROOT used,used
R16876 T21199 T21198 prep as,used
R16877 T21200 T21199 pobj substrates,as
R16878 T21201 T21198 punct .,used
R16879 T21202 T21206 det The,assay
R16880 T21203 T21206 nmod in,assay
R16881 T21204 T21206 amod vitro,assay
R16882 T21205 T21206 compound kinase,assay
R16883 T21206 T21208 nsubjpass assay,performed
R16884 T21207 T21208 auxpass was,performed
R16885 T21208 T21208 ROOT performed,performed
R16886 T21209 T21208 prep as,performed
R16887 T21210 T21211 advmod previously,described29
R16888 T21211 T21209 pobj described29,as
R16889 T21212 T21208 punct .,performed
R16890 T21213 T21221 advmod Briefly,substrate
R16891 T21214 T21221 punct ",",substrate
R16892 T21215 T21221 nsubj enzyme,substrate
R16893 T21216 T21218 punct (,ng
R16894 T21217 T21218 nummod 100,ng
R16895 T21218 T21215 appos ng,enzyme
R16896 T21219 T21218 punct ),ng
R16897 T21220 T21218 cc and,ng
R16898 T21221 T21221 ROOT substrate,substrate
R16899 T21222 T21224 punct (,μg
R16900 T21223 T21224 nummod 2,μg
R16901 T21224 T21221 appos μg,substrate
R16902 T21225 T21221 punct ),substrate
R16903 T21226 T21227 auxpass were,co-incubated
R16904 T21227 T21227 ROOT co-incubated,co-incubated
R16905 T21228 T21227 prep in,co-incubated
R16906 T21229 T21231 compound IKK,buffer
R16907 T21230 T21231 compound reaction,buffer
R16908 T21231 T21228 pobj buffer,in
R16909 T21232 T21240 punct (,]
R16910 T21233 T21235 nummod 25,Tris
R16911 T21234 T21235 compound mM,Tris
R16560 T20743 T20742 pobj S209A,for
R16561 T20744 T20715 punct .,generated
R16562 T20745 T20746 det All,mutants
R16563 T20746 T20748 nsubjpass mutants,verified
R16564 T20747 T20748 auxpass were,verified
R16565 T20748 T20748 ROOT verified,verified
R16566 T20749 T20748 agent by,verified
R16567 T20750 T20751 compound DNA,sequencing
R16568 T20751 T20749 pobj sequencing,by
R16569 T20752 T20748 punct .,verified
R16630 T20907 T20915 nsubjpass 32P,labeled
R16631 T20908 T20907 prep in,32P
R16632 T20909 T20908 pobj vivo,in
R16633 T20910 T20915 prep Labeling,labeled
R16634 T20911 T20910 dobj HEK,Labeling
R16635 T20912 T20913 nummod 293T,cells
R16636 T20913 T20915 nsubjpass cells,labeled
R16637 T20914 T20915 auxpass were,labeled
R16638 T20915 T20915 ROOT labeled,labeled
R16639 T20916 T20915 prep with,labeled
R16640 T20917 T20919 nummod 2,32P-orthophosphate
R16641 T20918 T20919 compound mCi/ml,32P-orthophosphate
R16642 T20919 T20916 pobj 32P-orthophosphate,with
R16643 T20920 T20919 punct (,32P-orthophosphate
R16644 T20921 T20922 compound Perkin,Elmer
R16645 T20922 T20919 appos Elmer,32P-orthophosphate
R16646 T20923 T20919 punct ),32P-orthophosphate
R16647 T20924 T20915 prep in,labeled
R16648 T20925 T20926 amod phosphate-free,medium
R16649 T20926 T20924 pobj medium,in
R16650 T20927 T20928 punct (,Invitrogen
R16651 T20928 T20926 appos Invitrogen,medium
R16652 T20929 T20915 punct ),labeled
R16653 T20930 T20915 prep for,labeled
R16654 T20931 T20933 nummod 2,Cells
R16655 T20932 T20933 compound h.,Cells
R16656 T20933 T20930 pobj Cells,for
R16657 T20934 T20936 auxpass were,left
R16658 T20935 T20936 advmod then,left
R16659 T20936 T20915 conj left,labeled
R16660 T20937 T20936 oprd untreated,left
R16661 T20938 T20937 cc or,untreated
R16662 T20939 T20937 conj treated,untreated
R16663 T20940 T20939 prep with,treated
R16664 T20941 T20940 pobj TNF,with
R16665 T20942 T20944 punct (,ng/ml
R16666 T20943 T20944 nummod 50,ng/ml
R16667 T20944 T20937 appos ng/ml,untreated
R16668 T20945 T20944 punct ",",ng/ml
R16669 T20946 T20947 compound R&D,Systems
R16670 T20947 T20944 appos Systems,ng/ml
R16671 T20948 T20944 punct ),ng/ml
R16672 T20949 T20936 prep for,left
R16673 T20950 T20951 amod indicated,periods
R16674 T20951 T20949 pobj periods,for
R16675 T20952 T20936 punct .,left
R16676 T20953 T20954 compound Cell,lysates
R16677 T20954 T20956 nsubjpass lysates,prepared
R16678 T20955 T20956 auxpass were,prepared
R16679 T20956 T20956 ROOT prepared,prepared
R16680 T20957 T20956 cc and,prepared
R16681 T20958 T20956 conj used,prepared
R16682 T20959 T20958 prep for,used
R16683 T20960 T20959 pobj immunoprecipitations,for
R16684 T20961 T20960 prep with,immunoprecipitations
R16685 T20962 T20963 amod RPS3,antibody
R16686 T20963 T20961 pobj antibody,with
R16687 T20964 T20956 punct .,prepared
R16832 T21155 T21166 prep In,purchased
R16833 T21156 T21161 compound Vitro,IKKβ
R16834 T21157 T21161 compound Kinase,IKKβ
R16835 T21158 T21161 compound Assay,IKKβ
R16836 T21159 T21160 compound Kinase-active,recombinant
R16837 T21160 T21161 compound recombinant,IKKβ
R16838 T21161 T21155 pobj IKKβ,In
R16839 T21162 T21161 cc and,IKKβ
R16840 T21163 T21164 compound IKKα,proteins
R16916 T21239 T21240 nummod 8.0,]
R16917 T21240 T21227 appos ],co-incubated
R16918 T21241 T21240 punct ",",]
R16919 T21242 T21244 nummod 50,KCl
R16920 T21243 T21244 compound mM,KCl
R16921 T21244 T21240 conj KCl,]
R16922 T21245 T21244 punct ",",KCl
R16923 T21246 T21248 nummod 10,MgCl2
R16924 T21247 T21248 compound mM,MgCl2
R16925 T21248 T21244 conj MgCl2,KCl
R16926 T21249 T21248 punct ",",MgCl2
R16927 T21250 T21252 nummod 1,DTT
R16928 T21251 T21252 compound mM,DTT
R16929 T21252 T21265 nmod DTT,buffer
R16930 T21253 T21252 punct ",",DTT
R16931 T21254 T21256 nummod 1,Na3VO4
R16932 T21255 T21256 compound mM,Na3VO4
R16933 T21256 T21252 conj Na3VO4,DTT
R16934 T21257 T21256 punct ",",Na3VO4
R16935 T21258 T21260 nummod 1,ATP
R16936 T21259 T21260 compound mM,ATP
R16937 T21260 T21256 appos ATP,Na3VO4
R16938 T21261 T21256 punct ),Na3VO4
R16939 T21262 T21256 cc or,Na3VO4
R16940 T21263 T21265 amod NleH1,buffer
R16941 T21264 T21265 compound reaction,buffer
R16942 T21265 T21248 appos buffer,MgCl2
R16943 T21266 T21273 punct (,]
R16944 T21267 T21273 nummod 50,]
R16945 T21268 T21271 compound mM,pH
R16946 T21269 T21271 compound Tris-HCl,pH
R16947 T21270 T21271 compound [,pH
R16948 T21271 T21273 compound pH,]
R16949 T21272 T21273 compound 7.6,]
R16950 T21273 T21248 conj ],MgCl2
R16951 T21274 T21273 punct ",",]
R16952 T21275 T21277 nummod 5,MgCl2
R16953 T21276 T21277 compound mM,MgCl2
R16954 T21277 T21273 conj MgCl2,]
R16955 T21278 T21277 punct ",",MgCl2
R16956 T21279 T21281 nummod 1,DTT
R16957 T21280 T21281 compound mM,DTT
R16958 T21281 T21277 conj DTT,MgCl2
R16959 T21282 T21281 punct ",",DTT
R16960 T21283 T21285 nummod 1,ATP
R16961 T21284 T21285 compound mM,ATP
R16962 T21285 T21281 appos ATP,DTT
R16963 T21286 T21281 punct ),DTT
R16964 T21287 T21281 prep with,DTT
R16965 T21288 T21290 nummod 0.5,32P-γ-ATP
R16966 T21289 T21290 compound μCi,32P-γ-ATP
R16967 T21290 T21287 pobj 32P-γ-ATP,with
R16968 T21291 T21293 punct (,Healthcare
R16969 T21292 T21293 compound GE,Healthcare
R16970 T21293 T21290 appos Healthcare,32P-γ-ATP
R16971 T21294 T21290 punct ),32P-γ-ATP
R16972 T21295 T21295 ROOT added,added
R16973 T21296 T21295 prep at,added
R16974 T21297 T21298 nummod 37,°
R16975 T21298 T21296 pobj °,at
R16976 T21299 T21295 npadvmod C,added
R16977 T21300 T21295 prep for,added
R16978 T21301 T21302 nummod 30,min
R16979 T21302 T21300 pobj min,for
R16980 T21303 T21295 punct .,added
R16981 T21304 T21305 det The,reactions
R16982 T21305 T21307 nsubjpass reactions,resolved
R16983 T21306 T21307 auxpass were,resolved
R16984 T21307 T21307 ROOT resolved,resolved
R16985 T21308 T21307 agent by,resolved
R16986 T21309 T21308 pobj SDS,by
R16987 T21310 T21307 npadvmod PAGE,resolved
R16988 T21311 T21310 cc and,PAGE
R16989 T21312 T21310 conj visualized,PAGE
R16990 T21313 T21312 agent by,visualized
R16991 T21314 T21313 pobj autoradiography,by
R16992 T21315 T21307 punct .,resolved
R17065 T21440 T21442 compound LC-MS/MS,GST
R17066 T21441 T21442 compound Analysis,GST
R17067 T21442 T21446 nsubjpass GST,incubated
R16912 T21235 T21240 nmod Tris,]
R16913 T21236 T21238 compound HCl,pH
R16914 T21237 T21238 compound [,pH
R16915 T21238 T21235 appos pH,Tris
R17185 T21602 T21602 ROOT RNAi,RNAi
R17186 T21603 T21602 cc and,RNAi
R17187 T21604 T21602 conj Transfection,RNAi
R17188 T21605 T21606 det The,siRNA
R17189 T21606 T21611 nmod siRNA,IKKα
R17190 T21607 T21606 punct (,siRNA
R17191 T21608 T21609 amod sense-strand,sequence
R17192 T21609 T21606 appos sequence,siRNA
R17193 T21610 T21611 punct ),IKKα
R17194 T21611 T21611 ROOT IKKα,IKKα
R17195 T21612 T21611 punct ",",IKKα
R17196 T21613 T21618 nummod 5,′
R17197 T21614 T21616 punct ′,AUGACAGAGAAUGAUCAUGUUCUGC
R17198 T21615 T21616 punct -,AUGACAGAGAAUGAUCAUGUUCUGC
R17199 T21616 T21618 nmod AUGACAGAGAAUGAUCAUGUUCUGC,′
R17200 T21617 T21618 nummod -3,′
R17201 T21618 T21611 appos ′,IKKα
R17202 T21619 T21611 punct ;,IKKα
R17203 T21620 T21611 conj IKKβ,IKKα
R17204 T21621 T21620 punct ",",IKKβ
R17205 T21622 T21627 nummod 5,′
R17206 T21623 T21625 punct ′,GCAGCAAGGAGAACAGAGGUUAAUA
R17207 T21624 T21625 punct -,GCAGCAAGGAGAACAGAGGUUAAUA
R17208 T21625 T21627 nmod GCAGCAAGGAGAACAGAGGUUAAUA,′
R17209 T21626 T21627 nummod -3,′
R17210 T21627 T21627 ROOT ′,′
R17211 T21628 T21627 punct ;,′
R17212 T21629 T21627 conj IκBα,′
R17213 T21630 T21629 punct ",",IκBα
R17214 T21631 T21636 nummod 5,′
R17215 T21632 T21634 punct ′,GAGCUCCGAGACUUUCGAGGAAAUA
R17216 T21633 T21634 punct -,GAGCUCCGAGACUUUCGAGGAAAUA
R17217 T21634 T21636 nmod GAGCUCCGAGACUUUCGAGGAAAUA,′
R17218 T21635 T21636 nummod -3,′
R17219 T21636 T21629 appos ′,IκBα
R17220 T21637 T21629 punct ;,IκBα
R17221 T21638 T21640 compound RPS3-3,UTR
R17222 T21639 T21640 compound ′,UTR
R17223 T21640 T21627 appos UTR,′
R17224 T21641 T21640 punct ",",UTR
R17225 T21642 T21647 nummod 5,′
R17226 T21643 T21645 punct ′,GGAUGUUGCUCUCUAAAGACC
R17227 T21644 T21645 punct -,GGAUGUUGCUCUCUAAAGACC
R17228 T21645 T21647 nmod GGAUGUUGCUCUCUAAAGACC,′
R17229 T21646 T21647 nummod -3,′
R17230 T21647 T21640 appos ′,UTR
R17231 T21648 T21649 punct (,Invitrogen
R17232 T21649 T21647 appos Invitrogen,′
R17233 T21650 T21649 punct ),Invitrogen
R17234 T21651 T21627 punct .,′
R17235 T21652 T21653 amod Transient,transfection
R17236 T21653 T21658 nsubj transfection,constructs
R17237 T21654 T21653 prep of,transfection
R17238 T21655 T21654 pobj siRNA,of
R17239 T21656 T21655 cc and,siRNA
R17240 T21657 T21655 conj DNA,siRNA
R17241 T21658 T21666 nsubjpass constructs,described
R17242 T21659 T21658 prep into,constructs
R17243 T21660 T21661 compound Jurkat,cells
R17244 T21661 T21659 pobj cells,into
R17245 T21662 T21661 cc and,cells
R17246 T21663 T21664 amod 293T,cells
R17247 T21664 T21661 conj cells,cells
R17248 T21665 T21666 auxpass was,described
R17249 T21666 T21666 ROOT described,described
R17250 T21667 T21666 dobj previously6,described
R17251 T21668 T21666 punct .,described
R17441 T21900 T21902 nummod 0.1,EDTA
R17442 T21901 T21902 compound mM,EDTA
R17443 T21902 T21898 appos EDTA,MgCl2
R17444 T21903 T21902 punct ",",EDTA
R17445 T21904 T21906 nummod 0.5,DTT
R17446 T21905 T21906 compound mM,DTT
R17447 T21906 T21902 appos DTT,EDTA
R17448 T21907 T21906 punct ",",DTT
R17449 T21908 T21909 nummod 0.4,%
R17450 T21909 T21910 compound %,NP-40
R17451 T21910 T21906 appos NP-40,DTT
R17452 T21911 T21910 punct ",",NP-40
R17453 T21912 T21914 nummod 0.5,PMSF
R17454 T21913 T21914 compound mM,PMSF
R17455 T21914 T21910 appos PMSF,NP-40
R17456 T21915 T21914 punct ",",PMSF
R17457 T21916 T21919 amod complete,cocktail
R17458 T21917 T21919 compound protease,cocktail
R17459 T21918 T21919 compound inhibitor,cocktail
R17460 T21919 T21914 appos cocktail,PMSF
R17461 T21920 T21914 punct ),PMSF
R17462 T21921 T21906 prep at,DTT
R17463 T21922 T21923 nummod 4,°
R17464 T21923 T21921 pobj °,at
R17465 T21924 T21906 conj C,DTT
R17466 T21925 T21906 prep for,DTT
R17467 T21926 T21927 nummod 5,min
R17468 T21927 T21925 pobj min,for
R17469 T21928 T21880 punct .,resuspended
R17470 T21929 T21931 nsubjpass Lysates,centrifuged
R17471 T21930 T21931 auxpass were,centrifuged
R17472 T21931 T21931 ROOT centrifuged,centrifuged
R17473 T21932 T21931 prep at,centrifuged
R17474 T21933 T21934 nummod 4,°
R17475 T21934 T21935 nummod °,C
R17476 T21935 T21932 pobj C,at
R17477 T21936 T21935 punct ",",C
R17478 T21937 T21938 nummod 500,×
R17479 T21938 T21939 compound ×,g
R17480 T21939 T21947 nsubjpass g,collected
R17481 T21940 T21939 prep for,g
R17482 T21941 T21942 nummod 3,min
R17483 T21942 T21940 pobj min,for
R17484 T21943 T21939 punct ",",g
R17485 T21944 T21939 cc and,g
R17486 T21945 T21939 conj supernatants,g
R17487 T21946 T21947 auxpass were,collected
R17488 T21947 T21931 conj collected,centrifuged
R17489 T21948 T21947 prep as,collected
R17490 T21949 T21950 amod cytosolic,fractions
R17491 T21950 T21948 pobj fractions,as
R17492 T21951 T21947 punct .,collected
R17493 T21952 T21954 nsubjpass Pellets,incubated
R17494 T21953 T21954 auxpass were,incubated
R17495 T21954 T21954 ROOT incubated,incubated
R17496 T21955 T21954 prep in,incubated
R17497 T21956 T21957 compound Buffer,C
R17068 T21443 T21442 cc or,GST
R17069 T21444 T21442 conj GST-RPS3,GST
R17070 T21445 T21446 auxpass was,incubated
R17071 T21446 T21446 ROOT incubated,incubated
R17072 T21447 T21446 prep with,incubated
R17073 T21448 T21450 compound recombinant,protein
R17074 T21449 T21450 compound IKKβ,protein
R17075 T21450 T21447 pobj protein,with
R17076 T21451 T21452 mark as,described
R17077 T21452 T21446 advcl described,incubated
R17078 T21453 T21452 advmod above,described
R17079 T21454 T21452 prep in,described
R17080 T21455 T21454 pcomp an,in
R17081 T21456 T21455 prep in,an
R17082 T21457 T21460 amod vitro,reaction
R17083 T21458 T21460 amod kinase,reaction
R17084 T21459 T21460 compound assay,reaction
R17085 T21460 T21456 pobj reaction,in
R17086 T21461 T21460 acl conducted,reaction
R17087 T21462 T21461 prep without,conducted
R17088 T21463 T21464 compound 32P-γ-ATP,labeling
R17089 T21464 T21462 pobj labeling,without
R17090 T21465 T21446 punct .,incubated
R17091 T21466 T21467 det The,reaction
R17092 T21467 T21469 nsubjpass reaction,separated
R17093 T21468 T21469 auxpass was,separated
R17094 T21469 T21469 ROOT separated,separated
R17095 T21470 T21469 agent by,separated
R17096 T21471 T21470 pobj SDS-PAGE,by
R17097 T21472 T21469 punct ",",separated
R17098 T21473 T21469 cc and,separated
R17099 T21474 T21476 det the,gel
R17100 T21475 T21476 compound protein,gel
R17101 T21476 T21478 nsubjpass gel,stained
R17102 T21477 T21478 auxpass was,stained
R17103 T21478 T21469 conj stained,separated
R17104 T21479 T21478 prep with,stained
R17105 T21480 T21481 compound Colloidal,Blue
R17106 T21481 T21479 pobj Blue,with
R17107 T21482 T21481 punct (,Blue
R17108 T21483 T21481 appos Invitrogen,Blue
R17109 T21484 T21481 punct ),Blue
R17110 T21485 T21478 punct .,stained
R17111 T21486 T21489 det The,fragments
R17112 T21487 T21489 amod corresponding,fragments
R17113 T21488 T21489 compound protein,fragments
R17114 T21489 T21491 nsubjpass fragments,excised
R17115 T21490 T21491 auxpass were,excised
R17116 T21491 T21491 ROOT excised,excised
R17117 T21492 T21491 cc and,excised
R17118 T21493 T21491 conj subjected,excised
R17119 T21494 T21495 aux to,trypsin
R17120 T21495 T21493 xcomp trypsin,subjected
R17121 T21496 T21495 dobj digestion,trypsin
R17122 T21497 T21496 cc and,digestion
R17123 T21498 T21496 conj LC-MS/MS,digestion
R17124 T21499 T21495 prep at,trypsin
R17125 T21500 T21503 det the,Center
R17126 T21501 T21503 compound Yale,Center
R17127 T21502 T21503 compound Cancer,Center
R17128 T21503 T21506 compound Center,Resource
R17129 T21504 T21506 compound Mass,Resource
R17130 T21505 T21506 compound Spectrometry,Resource
R17131 T21506 T21499 pobj Resource,at
R17132 T21507 T21506 punct (,Resource
R17133 T21508 T21509 compound New,Haven
R17134 T21509 T21506 appos Haven,Resource
R17135 T21510 T21509 punct ",",Haven
R17136 T21511 T21509 conj CT,Haven
R17137 T21512 T21506 punct ),Resource
R17138 T21513 T21491 punct .,excised
R17404 T21863 T21866 compound Subcellular,fractionation
R17405 T21864 T21866 compound Fractionation,fractionation
R17406 T21865 T21866 compound Subcellular,fractionation
R17407 T21866 T21868 nsubjpass fractionation,performed
R17408 T21867 T21868 auxpass was,performed
R17409 T21868 T21868 ROOT performed,performed
R17410 T21869 T21868 agent by,performed
R17411 T21870 T21871 compound differential,centrifugation
R17412 T21871 T21869 pobj centrifugation,by
R17413 T21872 T21868 prep as,performed
R17414 T21873 T21874 advmod previously,described6
R17415 T21874 T21872 pobj described6,as
R17416 T21875 T21868 punct .,performed
R17417 T21876 T21880 advmod Briefly,resuspended
R17418 T21877 T21880 punct ",",resuspended
R17419 T21878 T21880 nsubjpass cells,resuspended
R17420 T21879 T21880 auxpass were,resuspended
R17421 T21880 T21880 ROOT resuspended,resuspended
R17422 T21881 T21880 prep in,resuspended
R17423 T21882 T21884 amod ice-cold,A
R17424 T21883 T21884 compound Buffer,A
R17425 T21884 T21881 pobj A,in
R17426 T21885 T21884 punct (,A
R17427 T21886 T21889 nummod 10,pH
R17428 T21887 T21889 compound mM,pH
R17429 T21888 T21889 compound HEPES,pH
R17430 T21889 T21884 appos pH,A
R17431 T21890 T21889 nummod 7.9,pH
R17432 T21891 T21889 punct ",",pH
R17433 T21892 T21894 nummod 10,KCl
R17434 T21893 T21894 compound mM,KCl
R17435 T21894 T21889 appos KCl,pH
R17436 T21895 T21894 punct ",",KCl
R17437 T21896 T21898 nummod 1.5,MgCl2
R17438 T21897 T21898 compound mM,MgCl2
R17439 T21898 T21894 appos MgCl2,KCl
R17440 T21899 T21898 punct ",",MgCl2
R17516 T21975 T21971 appos glycerol,MgCl2
R17517 T21976 T21971 punct ",",MgCl2
R17518 T21977 T21979 nummod 0.5,PMSF
R17519 T21978 T21979 compound mM,PMSF
R17520 T21979 T21971 appos PMSF,MgCl2
R17521 T21980 T21979 punct ",",PMSF
R17522 T21981 T21983 nummod 0.2,EDTA
R17523 T21982 T21983 compound mM,EDTA
R17524 T21983 T21979 appos EDTA,PMSF
R17525 T21984 T21983 punct ",",EDTA
R17526 T21985 T21987 nummod 0.5,DTT
R17527 T21986 T21987 compound mM,DTT
R17528 T21987 T21983 appos DTT,EDTA
R17529 T21988 T21987 punct ",",DTT
R17530 T21989 T21992 amod complete,cocktail
R17531 T21990 T21992 compound protease,cocktail
R17532 T21991 T21992 compound inhibitor,cocktail
R17533 T21992 T21987 appos cocktail,DTT
R17534 T21993 T21987 punct ),DTT
R17535 T21994 T21979 prep at,PMSF
R17536 T21995 T21996 nummod 4,°
R17537 T21996 T21994 pobj °,at
R17538 T21997 T21979 conj C,PMSF
R17539 T21998 T21979 prep for,PMSF
R17540 T21999 T22000 nummod 10,min
R17541 T22000 T21998 pobj min,for
R17542 T22001 T21954 punct .,incubated
R17543 T22002 T22004 nsubjpass Supernatants,collected
R17544 T22003 T22004 auxpass were,collected
R17545 T22004 T22004 ROOT collected,collected
R17546 T22005 T22004 prep as,collected
R17547 T22006 T22007 amod nuclear,fractions
R17548 T22007 T22005 pobj fractions,as
R17549 T22008 T22004 prep following,collected
R17550 T22009 T22010 det a,centrifuge
R17551 T22010 T22008 pobj centrifuge,following
R17552 T22011 T22010 prep at,centrifuge
R17553 T22012 T22013 nummod 4,°
R17554 T22013 T22011 pobj °,at
R17555 T22014 T22018 nmod C,g
R17556 T22015 T22014 punct ",",C
R17557 T22016 T22017 nummod "13,800",×
R17558 T22017 T22018 compound ×,g
R17559 T22018 T22010 npadvmod g,centrifuge
R17560 T22019 T22018 prep for,g
R17561 T22020 T22021 nummod 10,min
R17562 T22021 T22019 pobj min,for
R17563 T22022 T22004 punct .,collected
R17629 T22111 T22112 compound Luciferase,Reporter
R17498 T21957 T21955 pobj C,in
R17499 T21958 T21957 punct (,C
R17500 T21959 T21962 nummod 20,pH7
R17501 T21960 T21962 compound mM,pH7
R17502 T21961 T21962 compound HEPES,pH7
R17503 T21962 T21957 appos pH7,C
R17504 T21963 T21962 nummod .9,pH7
R17505 T21964 T21962 punct ",",pH7
R17506 T21965 T21967 nummod 420,NaCl
R17507 T21966 T21967 compound mM,NaCl
R17508 T21967 T21962 appos NaCl,pH7
R17509 T21968 T21967 punct ",",NaCl
R17510 T21969 T21971 nummod 1.5,MgCl2
R17511 T21970 T21971 compound mM,MgCl2
R17512 T21971 T21967 appos MgCl2,NaCl
R17513 T21972 T21971 punct ",",MgCl2
R17514 T21973 T21974 nummod 25,%
R17515 T21974 T21975 compound %,glycerol
R17666 T22148 T22149 advmod together,with
R17667 T22149 T22129 prep with,cotransfected
R17668 T22150 T22151 amod indicated,plasmids
R17669 T22151 T22149 pobj plasmids,with
R17670 T22152 T22129 punct .,cotransfected
R17671 T22153 T22154 nsubj Cells,were
R17672 T22154 T22154 ROOT were,were
R17673 T22155 T22154 acomp cultured,were
R17674 T22156 T22155 prep for,cultured
R17675 T22157 T22158 quantmod 1,2
R17676 T22158 T22159 nummod 2,days
R17677 T22159 T22156 pobj days,for
R17678 T22160 T22155 cc and,cultured
R17679 T22161 T22162 advmod then,stimulated
R17680 T22162 T22155 conj stimulated,cultured
R17681 T22163 T22162 prep in,stimulated
R17682 T22164 T22163 pobj triplicate,in
R17683 T22165 T22162 prep before,stimulated
R17684 T22166 T22165 pobj harvest,before
R17685 T22167 T22154 punct .,were
R17686 T22168 T22170 nsubjpass Lysates,analyzed
R17687 T22169 T22170 auxpass were,analyzed
R17688 T22170 T22170 ROOT analyzed,analyzed
R17689 T22171 T22170 advcl using,analyzed
R17690 T22172 T22174 det the,Kit
R17691 T22173 T22174 compound Dual-Luciferase,Kit
R17692 T22174 T22171 dobj Kit,using
R17693 T22175 T22174 punct (,Kit
R17694 T22176 T22174 appos Promega,Kit
R17695 T22177 T22174 punct ),Kit
R17696 T22178 T22170 punct .,analyzed
R17735 T22257 T22258 compound Chromatin,Immunoprecipitation
R17736 T22258 T22258 ROOT Immunoprecipitation,Immunoprecipitation
R17737 T22259 T22260 punct (,ChIP
R17738 T22260 T22258 appos ChIP,Immunoprecipitation
R17739 T22261 T22258 punct ),Immunoprecipitation
R17740 T22262 T22263 compound ChIP,assays
R17870 T22423 T22426 compound Immunofluorescence,microscopy
R17871 T22424 T22426 compound Microscopy,microscopy
R17872 T22425 T22426 compound Confocal,microscopy
R17873 T22426 T22428 nsubjpass microscopy,performed
R17874 T22427 T22428 auxpass was,performed
R17875 T22428 T22428 ROOT performed,performed
R17876 T22429 T22428 prep as,performed
R17877 T22430 T22431 advmod previously,described6
R17878 T22431 T22429 pobj described6,as
R17879 T22432 T22428 punct .,performed
R17880 T22433 T22437 advmod Briefly,fixed
R17881 T22434 T22437 punct ",",fixed
R17882 T22435 T22437 nsubjpass cells,fixed
R17883 T22436 T22437 auxpass were,fixed
R17884 T22437 T22437 ROOT fixed,fixed
R17885 T22438 T22437 prep with,fixed
R17886 T22439 T22440 nummod 4,%
R17887 T22440 T22441 compound %,paraformaldehyde
R17888 T22441 T22438 pobj paraformaldehyde,with
R17889 T22442 T22441 prep in,paraformaldehyde
R17890 T22443 T22442 pobj PBS,in
R17966 T22519 T22518 acl mounted,cover
R17967 T22520 T22519 prep for,mounted
R17968 T22521 T22522 compound fluorescence,microscopy
R17969 T22522 T22520 pobj microscopy,for
R17970 T22523 T22512 punct .,rinsed
R18230 T22801 T22807 nsubjpass Immunoprecipitation,harvested
R18231 T22802 T22801 cc and,Immunoprecipitation
R18232 T22803 T22801 conj immunoblot,Immunoprecipitation
R18233 T22804 T22805 det The,cells
R18234 T22805 T22807 nsubjpass cells,harvested
R18235 T22806 T22807 auxpass were,harvested
R18236 T22807 T22807 ROOT harvested,harvested
R18237 T22808 T22807 cc and,harvested
R18238 T22809 T22807 conj lysed,harvested
R18239 T22810 T22809 prep on,lysed
R18240 T22811 T22810 pobj ice,on
R18241 T22812 T22809 prep by,lysed
R18242 T22813 T22814 nummod 0.4,ml
R18243 T22814 T22812 pobj ml,by
R18244 T22815 T22814 prep of,ml
R18245 T22816 T22819 det the,buffer
R18246 T22817 T22819 amod modified,buffer
R18247 T22818 T22819 compound RIPA,buffer
R18248 T22819 T22815 pobj buffer,of
R18249 T22820 T22827 punct (,]
R18250 T22821 T22827 nummod 50,]
R18251 T22822 T22825 compound mM,pH
R18252 T22823 T22825 compound Tris-HCl,pH
R18253 T22824 T22825 compound [,pH
R18254 T22825 T22827 nmod pH,]
R18255 T22826 T22827 nummod 7.4,]
R18256 T22827 T22819 appos ],buffer
R18257 T22828 T22827 punct ",",]
R18258 T22829 T22830 nummod 1,%
R18259 T22830 T22831 compound %,NP-40
R18260 T22831 T22827 appos NP-40,]
R18261 T22832 T22831 punct ",",NP-40
R18262 T22833 T22834 nummod 0.25,%
R18263 T22834 T22835 nsubj %,Na-deoxycholate
R18264 T22835 T22831 conj Na-deoxycholate,NP-40
R18265 T22836 T22835 punct ",",Na-deoxycholate
R18266 T22837 T22839 nummod 150,NaCl
R18267 T22838 T22839 compound mM,NaCl
R18268 T22839 T22835 appos NaCl,Na-deoxycholate
R18269 T22840 T22839 punct ",",NaCl
R18270 T22841 T22843 nummod 1,EDTA
R18271 T22842 T22843 compound mM,EDTA
R18272 T22843 T22839 appos EDTA,NaCl
R18273 T22844 T22843 punct ",",EDTA
R18274 T22845 T22847 nummod 1,PMSF
R18275 T22846 T22847 compound mM,PMSF
R18276 T22847 T22843 appos PMSF,EDTA
R18277 T22848 T22847 punct ",",PMSF
R18278 T22849 T22851 nummod 1,Na3VO4
R18279 T22850 T22851 compound mM,Na3VO4
R18280 T22851 T22847 appos Na3VO4,PMSF
R18281 T22852 T22851 punct ",",Na3VO4
R18282 T22853 T22855 nummod 1,NaF
R18283 T22854 T22855 compound mM,NaF
R18284 T22855 T22851 appos NaF,Na3VO4
R17630 T22112 T22118 compound Reporter,assays
R17631 T22113 T22118 compound Gene,assays
R17632 T22114 T22118 compound Assays,assays
R17633 T22115 T22118 compound Luciferase,assays
R17634 T22116 T22117 compound reporter,gene
R17635 T22117 T22118 compound gene,assays
R17636 T22118 T22120 nsubjpass assays,performed
R17637 T22119 T22120 auxpass were,performed
R17638 T22120 T22120 ROOT performed,performed
R17639 T22121 T22120 prep as,performed
R17640 T22122 T22123 advmod previously,described6
R17641 T22123 T22121 pobj described6,as
R17642 T22124 T22120 punct .,performed
R17643 T22125 T22129 advmod Briefly,cotransfected
R17644 T22126 T22129 punct ",",cotransfected
R17645 T22127 T22129 nsubjpass cells,cotransfected
R17646 T22128 T22129 auxpass were,cotransfected
R17647 T22129 T22129 ROOT cotransfected,cotransfected
R17648 T22130 T22129 prep at,cotransfected
R17649 T22131 T22132 det a,ratio
R17650 T22132 T22130 pobj ratio,at
R17651 T22133 T22132 prep of,ratio
R17652 T22134 T22133 pobj 10:1,of
R17653 T22135 T22134 prep with,10:1
R17654 T22136 T22140 amod various,constructs
R17655 T22137 T22140 amod promoter-driven,constructs
R17656 T22138 T22139 advmod firefly,luciferase
R17657 T22139 T22140 amod luciferase,constructs
R17658 T22140 T22135 pobj constructs,with
R17659 T22141 T22140 prep to,constructs
R17660 T22142 T22146 det the,plasmid
R17661 T22143 T22146 compound Renilla,plasmid
R17662 T22144 T22145 compound luciferase,pTKRL
R17663 T22145 T22146 compound pTKRL,plasmid
R17664 T22146 T22141 pobj plasmid,to
R17665 T22147 T22129 punct ",",cotransfected
R17741 T22263 T22265 nsubjpass assays,performed
R17742 T22264 T22265 auxpass was,performed
R17743 T22265 T22265 ROOT performed,performed
R17744 T22266 T22265 prep as,performed
R17745 T22267 T22268 advmod previously,described6
R17746 T22268 T22266 pobj described6,as
R17747 T22269 T22265 punct .,performed
R17748 T22270 T22271 det The,primers
R17749 T22271 T22272 nsubj primers,used
R17750 T22272 T22272 ROOT used,used
R17751 T22273 T22274 aux to,amplify
R17752 T22274 T22272 xcomp amplify,used
R17753 T22275 T22277 det the,region
R17754 T22276 T22277 compound promoter,region
R17755 T22277 T22274 dobj region,amplify
R17756 T22278 T22293 advmod adjacent,been
R17757 T22279 T22278 prep to,adjacent
R17758 T22280 T22282 det the,sites
R17759 T22281 T22282 amod κB,sites
R17760 T22282 T22279 pobj sites,to
R17761 T22283 T22282 prep of,sites
R17762 T22284 T22283 pobj IL8,of
R17763 T22285 T22284 cc and,IL8
R17764 T22286 T22284 conj NFKBIA,IL8
R17765 T22287 T22282 punct ",",sites
R17766 T22288 T22290 advmod as,as
R17767 T22289 T22290 advmod well,as
R17768 T22290 T22282 cc as,sites
R17769 T22291 T22282 conj ACTB,sites
R17770 T22292 T22293 aux have,been
R17771 T22293 T22294 auxpass been,described6
R17772 T22294 T22272 conj described6,used
R17773 T22295 T22272 punct .,used
R17891 T22444 T22437 cc and,fixed
R17892 T22445 T22447 advmod then,mounted
R17893 T22446 T22447 nsubj Cellspin,mounted
R17894 T22447 T22437 conj mounted,fixed
R17895 T22448 T22447 prep onto,mounted
R17896 T22449 T22448 pobj slides,onto
R17897 T22450 T22447 punct .,mounted
R17898 T22451 T22453 det The,cells
R17899 T22452 T22453 amod fixed,cells
R17900 T22453 T22456 nsubjpass cells,permeabilized
R17901 T22454 T22456 auxpass were,permeabilized
R17902 T22455 T22456 advmod then,permeabilized
R17903 T22456 T22456 ROOT permeabilized,permeabilized
R17904 T22457 T22456 prep with,permeabilized
R17905 T22458 T22459 nummod 0.05,%
R17906 T22459 T22461 compound %,X-100
R17907 T22460 T22461 compound Triton,X-100
R17908 T22461 T22457 pobj X-100,with
R17909 T22462 T22461 prep in,X-100
R17910 T22463 T22462 pobj PBS,in
R17911 T22464 T22456 cc and,permeabilized
R17912 T22465 T22456 conj stained,permeabilized
R17913 T22466 T22465 prep with,stained
R17914 T22467 T22470 amod FITC-conjugated,antibodies
R17915 T22468 T22470 nmod rabbit,antibodies
R17916 T22469 T22470 amod anti-RPS3,antibodies
R17917 T22470 T22466 pobj antibodies,with
R17918 T22471 T22473 punct (,Biotech
R17919 T22472 T22473 compound Primm,Biotech
R17920 T22473 T22470 appos Biotech,antibodies
R17921 T22474 T22470 punct ),antibodies
R17922 T22475 T22465 punct ",",stained
R17923 T22476 T22465 cc or,stained
R17924 T22477 T22479 nmod AlexaFluor,rat
R17925 T22478 T22479 amod 594-conjugated,rat
R17926 T22479 T22481 nmod rat,antibodies
R17927 T22480 T22481 amod anti-Flag,antibodies
R17928 T22481 T22456 conj antibodies,permeabilized
R17929 T22482 T22481 punct (,antibodies
R17930 T22483 T22481 appos BD,antibodies
R17931 T22484 T22481 punct ),antibodies
R17932 T22485 T22481 prep for,antibodies
R17933 T22486 T22487 nummod 40,min
R17934 T22487 T22485 pobj min,for
R17935 T22488 T22489 advmod together,with
R17936 T22489 T22481 prep with,antibodies
R17937 T22490 T22491 nummod 1,μg
R17938 T22491 T22493 compound μg,ml
R17939 T22492 T22493 compound /,ml
R17940 T22493 T22489 pobj ml,with
R17941 T22494 T22493 prep of,ml
R17942 T22495 T22496 compound Hoechst,33342
R17943 T22496 T22494 pobj 33342,of
R17944 T22497 T22498 punct (,Sigma
R17945 T22498 T22493 appos Sigma,ml
R17946 T22499 T22481 punct ),antibodies
R17947 T22500 T22481 prep for,antibodies
R17948 T22501 T22502 nummod 5,min
R17949 T22502 T22500 pobj min,for
R17950 T22503 T22502 prep at,min
R17951 T22504 T22505 nummod 25,°
R17952 T22505 T22503 pobj °,at
R17953 T22506 T22506 ROOT C,C
R17954 T22507 T22456 punct .,permeabilized
R17955 T22508 T22509 det The,slides
R17956 T22509 T22512 nsubjpass slides,rinsed
R17957 T22510 T22512 auxpass were,rinsed
R17958 T22511 T22512 advmod then,rinsed
R17959 T22512 T22512 ROOT rinsed,rinsed
R17960 T22513 T22512 prep with,rinsed
R17961 T22514 T22513 pobj PBS,with
R17962 T22515 T22516 nummod three,times
R17963 T22516 T22512 npadvmod times,rinsed
R17964 T22517 T22512 cc and,rinsed
R17965 T22518 T22512 conj cover,rinsed
R18341 T22912 T22911 pobj immunoprecipitation,to
R18342 T22913 T22910 prep by,subjected
R18343 T22914 T22913 pcomp adding,by
R18344 T22915 T22918 nummod 10,antibody
R18345 T22916 T22918 amod mg/ml,antibody
R18346 T22917 T22918 amod appropriate,antibody
R18347 T22918 T22914 dobj antibody,adding
R18348 T22919 T22918 cc plus,antibody
R18349 T22920 T22921 nummod 30,ml
R18350 T22921 T22918 conj ml,antibody
R18351 T22922 T22921 prep of,ml
R18352 T22923 T22922 pobj protein,of
R18353 T22924 T22921 conj G-agarose,ml
R18354 T22925 T22926 punct (,Roche
R18285 T22856 T22857 punct ),supplemented
R18286 T22857 T22807 conj supplemented,harvested
R18287 T22858 T22857 prep with,supplemented
R18288 T22859 T22863 nummod 1,cocktail
R18289 T22860 T22863 nummod ×,cocktail
R18290 T22861 T22863 compound protease,cocktail
R18291 T22862 T22863 compound inhibitor,cocktail
R18292 T22863 T22858 pobj cocktail,with
R18293 T22864 T22863 punct (,cocktail
R18294 T22865 T22863 appos Roche,cocktail
R18295 T22866 T22863 punct ),cocktail
R18296 T22867 T22863 cc and,cocktail
R18297 T22868 T22869 nummod 1,×
R18298 T22869 T22872 nummod ×,cocktail
R18299 T22870 T22872 nmod phosphatase,cocktail
R18300 T22871 T22872 compound inhibitor,cocktail
R18301 T22872 T22863 conj cocktail,cocktail
R18302 T22873 T22857 conj set,supplemented
R18303 T22874 T22873 dobj I,set
R18304 T22875 T22877 punct (,Biosciences
R18305 T22876 T22877 compound EMD,Biosciences
R18306 T22877 T22874 appos Biosciences,I
R18307 T22878 T22873 punct ),set
R18308 T22879 T22873 prep for,set
R18309 T22880 T22881 nummod 30,min
R18310 T22881 T22879 pobj min,for
R18311 T22882 T22807 punct .,harvested
R18312 T22883 T22884 det The,lysates
R18313 T22884 T22886 nsubjpass lysates,centrifuged
R18314 T22885 T22886 auxpass were,centrifuged
R18315 T22886 T22886 ROOT centrifuged,centrifuged
R18316 T22887 T22886 prep at,centrifuged
R18317 T22888 T22889 nummod "10,000",×
R18318 T22889 T22887 pobj ×,at
R18319 T22890 T22886 advmod g,centrifuged
R18320 T22891 T22886 prep at,centrifuged
R18321 T22892 T22893 nummod 4,°
R18322 T22893 T22891 pobj °,at
R18323 T22894 T22886 conj C,centrifuged
R18324 T22895 T22899 mark for,remove
R18325 T22896 T22897 nummod 10,min
R18326 T22897 T22899 nsubj min,remove
R18327 T22898 T22899 aux to,remove
R18328 T22899 T22886 advcl remove,centrifuged
R18329 T22900 T22901 amod insoluble,material
R18330 T22901 T22899 dobj material,remove
R18331 T22902 T22886 punct .,centrifuged
R18332 T22903 T22910 prep After,subjected
R18333 T22904 T22903 pcomp normalizing,After
R18334 T22905 T22906 compound protein,concentrations
R18335 T22906 T22904 dobj concentrations,normalizing
R18336 T22907 T22910 punct ",",subjected
R18337 T22908 T22910 nsubjpass lysates,subjected
R18338 T22909 T22910 auxpass were,subjected
R18339 T22910 T22910 ROOT subjected,subjected
R18340 T22911 T22910 prep to,subjected
R18521 T23138 T23152 nsubjpass ELISA,measured
R18522 T23139 T23140 det The,amount
R18523 T23140 T23152 nsubjpass amount,measured
R18524 T23141 T23140 prep of,amount
R18525 T23142 T23143 compound IL-8,present
R18526 T23143 T23141 pobj present,of
R18527 T23144 T23143 prep in,present
R18528 T23145 T23144 pobj supernatants,in
R18529 T23146 T23145 acl collected,supernatants
R18530 T23147 T23146 prep from,collected
R18531 T23148 T23150 compound Jurkat,culture
R18532 T23149 T23150 compound cell,culture
R18533 T23150 T23147 pobj culture,from
R18534 T23151 T23152 auxpass was,measured
R18535 T23152 T23152 ROOT measured,measured
R18536 T23153 T23152 advcl using,measured
R18537 T23154 T23156 det a,Interleukin-8
R18538 T23155 T23156 compound Human,Interleukin-8
R18539 T23156 T23153 dobj Interleukin-8,using
R18540 T23157 T23158 compound ELISA,Ready-SET-Go
R18541 T23158 T23159 compound Ready-SET-Go,kit
R18542 T23159 T23156 appos kit,Interleukin-8
R18543 T23160 T23159 punct (,kit
R18544 T23161 T23159 appos eBioscience,kit
R18545 T23162 T23159 punct ),kit
R18546 T23163 T23152 prep according,measured
R18547 T23164 T23163 prep to,according
R18548 T23165 T23166 det the,manufacturer
R18549 T23166 T23168 poss manufacturer,instructions
R18550 T23167 T23166 case 's,manufacturer
R18551 T23168 T23164 pobj instructions,to
R18552 T23169 T23152 punct .,measured
R18571 T23214 T23216 compound Cell,HeLa
R18572 T23215 T23216 compound Infections,HeLa
R18573 T23216 T23217 compound HeLa,cells
R18574 T23217 T23219 nsubjpass cells,infected
R18575 T23218 T23219 auxpass were,infected
R18576 T23219 T23219 ROOT infected,infected
R18577 T23220 T23219 prep with,infected
R18578 T23221 T23223 compound E.,O157
R18579 T23222 T23223 compound coli,O157
R18580 T23223 T23220 pobj O157,with
R18581 T23224 T23223 punct :,O157
R18582 T23225 T23223 conj H7,O157
R18583 T23226 T23225 cc or,H7
R18584 T23227 T23229 compound C.,strains
R18585 T23228 T23229 compound rodentium,strains
R18586 T23229 T23219 npadvmod strains,infected
R18587 T23230 T23231 mark as,described
R18588 T23231 T23219 advcl described,infected
R18589 T23232 T23231 dobj previously9,described
R18590 T23233 T23219 punct .,infected
R18630 T23283 T23284 compound Immunohistochemistry,Gnotobiotic
R18631 T23284 T23285 compound Gnotobiotic,piglets
R18632 T23285 T23287 nsubjpass piglets,infected
R18633 T23286 T23287 auxpass were,infected
R18634 T23287 T23287 ROOT infected,infected
R18635 T23288 T23287 prep with,infected
R18636 T23289 T23291 compound E.,O157
R18637 T23290 T23291 compound coli,O157
R18638 T23291 T23288 pobj O157,with
R18639 T23292 T23291 punct :,O157
R18640 T23293 T23294 compound H7,strains
R18641 T23294 T23296 nsubj strains,described
R18642 T23295 T23296 mark as,described
R18643 T23296 T23287 advcl described,infected
R18644 T23297 T23296 dobj previously9,described
R18645 T23298 T23287 punct .,infected
R18646 T23299 T23301 amod Spiral,specimens
R18647 T23300 T23301 compound colon,specimens
R18648 T23301 T23303 nsubjpass specimens,collected
R18649 T23302 T23303 auxpass were,collected
R18650 T23303 T23303 ROOT collected,collected
R18651 T23304 T23303 prep at,collected
R18652 T23305 T23304 pobj necropsy,at
R18653 T23306 T23303 cc and,collected
R18654 T23307 T23303 conj embedded,collected
R18655 T23308 T23307 prep in,embedded
R18656 T23309 T23308 pobj paraffin,in
R18657 T23310 T23303 punct .,collected
R18658 T23311 T23312 compound Paraffin,sectioning
R18659 T23312 T23320 nsubjpass sectioning,performed
R18660 T23313 T23312 cc and,sectioning
R18661 T23314 T23320 nsubjpass immunohistochemical,performed
R18355 T22926 T22924 appos Roche,G-agarose
R18356 T22927 T22924 punct ),G-agarose
R18357 T22928 T22910 punct ",",subjected
R18358 T22929 T22910 cc and,subjected
R18359 T22930 T22910 conj rotated,subjected
R18360 T22931 T22930 prep for,rotated
R18361 T22932 T22933 advmod at,least
R18362 T22933 T22934 advmod least,2
R18363 T22934 T22935 nummod 2,h
R18364 T22935 T22931 pobj h,for
R18365 T22936 T22930 prep at,rotated
R18366 T22937 T22938 nummod 4,°
R18367 T22938 T22936 pobj °,at
R18368 T22939 T22930 conj C,rotated
R18369 T22940 T22910 punct .,subjected
R18370 T22941 T22942 det The,precipitates
R18371 T22942 T22944 nsubjpass precipitates,washed
R18372 T22943 T22944 auxpass were,washed
R18373 T22944 T22944 ROOT washed,washed
R18374 T22945 T22946 advmod at,least
R18375 T22946 T22947 advmod least,five
R18376 T22947 T22949 nummod five,with
R18377 T22948 T22947 quantmod times,five
R18378 T22949 T22944 prep with,washed
R18379 T22950 T22952 amod cold,buffer
R18380 T22951 T22952 compound lysis,buffer
R18381 T22952 T22949 pobj buffer,with
R18382 T22953 T22952 acl followed,buffer
R18383 T22954 T22953 agent by,followed
R18384 T22955 T22954 pobj separation,by
R18385 T22956 T22955 prep by,separation
R18386 T22957 T22956 pobj SDS-PAGE,by
R18387 T22958 T22953 prep under,followed
R18388 T22959 T22962 amod reduced,conditions
R18389 T22960 T22959 cc and,reduced
R18390 T22961 T22962 compound denaturing,conditions
R18391 T22962 T22958 pobj conditions,under
R18392 T22963 T22944 punct .,washed
R18393 T22964 T22965 compound Nitrocellulose,membranes
R18394 T22965 T22967 nsubjpass membranes,blocked
R18395 T22966 T22967 auxpass were,blocked
R18396 T22967 T22967 ROOT blocked,blocked
R18397 T22968 T22967 prep in,blocked
R18398 T22969 T22970 nummod 5,%
R18399 T22970 T22972 compound %,milk
R18400 T22971 T22972 compound nonfat,milk
R18401 T22972 T22968 pobj milk,in
R18402 T22973 T22967 prep in,blocked
R18403 T22974 T22975 nummod 0.1,%
R18404 T22975 T22982 npadvmod %,probed
R18405 T22976 T22977 quantmod PBS-Tween,20
R18406 T22977 T22982 nsubj 20,probed
R18407 T22978 T22977 punct (,20
R18408 T22979 T22977 quantmod PBS-T,20
R18409 T22980 T22977 punct ),20
R18410 T22981 T22977 punct ",",20
R18411 T22982 T22967 conj probed,blocked
R18412 T22983 T22982 prep with,probed
R18413 T22984 T22985 amod specific,antibodies
R18414 T22985 T22983 pobj antibodies,with
R18415 T22986 T22987 mark as,described
R18416 T22987 T22982 advcl described,probed
R18417 T22988 T22987 dobj previously6,described
R18418 T22989 T22982 punct .,probed
R18419 T22990 T22998 prep For,transferred
R18420 T22991 T22990 pcomp immunoblotting,For
R18421 T22992 T22991 prep of,immunoblotting
R18422 T22993 T22994 amod phosphorylated,proteins
R18423 T22994 T22992 pobj proteins,of
R18424 T22995 T22998 punct ",",transferred
R18425 T22996 T22998 nsubjpass gels,transferred
R18426 T22997 T22998 auxpass were,transferred
R18427 T22998 T22998 ROOT transferred,transferred
R18428 T22999 T22998 prep to,transferred
R18429 T23000 T23003 amod methanol-treated,membranes
R18430 T23001 T23003 compound polyvinylidene,membranes
R18431 T23002 T23003 compound chloride,membranes
R18432 T23003 T22999 pobj membranes,to
R18433 T23004 T22998 punct ",",transferred
R18434 T23005 T22998 conj retreated,transferred
R18435 T23006 T23005 prep with,retreated
R18436 T23007 T23006 pobj methanol,with
R18437 T23008 T23005 punct ",",retreated
R18438 T23009 T23005 cc and,retreated
R18439 T23010 T23005 conj dried,retreated
R18440 T23011 T23010 prep for,dried
R18441 T23012 T23013 nummod 30,min
R18442 T23013 T23011 pobj min,for
R18443 T23014 T22998 punct .,transferred
R18444 T23015 T23017 nsubjpass Blots,blocked
R18445 T23016 T23017 auxpass were,blocked
R18446 T23017 T23017 ROOT blocked,blocked
R18447 T23018 T23017 prep in,blocked
R18448 T23019 T23020 nummod 5,%
R18449 T23020 T23023 compound %,albumin
R18450 T23021 T23022 amod bovine,serum
R18451 T23022 T23023 compound serum,albumin
R18452 T23023 T23018 pobj albumin,in
R18453 T23024 T23017 prep in,blocked
R18454 T23025 T23026 nummod 0.1,%
R18455 T23026 T23024 pobj %,in
R18456 T23027 T23028 nsubj Tris,buffered
R18457 T23028 T23017 advcl buffered,blocked
R18458 T23029 T23028 dobj saline-Tween,buffered
R18459 T23030 T23029 nummod 20,saline-Tween
R18460 T23031 T23032 punct (,TBS-T
R18461 T23032 T23036 nsubj TBS-T,probed
R18462 T23033 T23032 punct ),TBS-T
R18463 T23034 T23032 punct ",",TBS-T
R18464 T23035 T23032 cc and,TBS-T
R18465 T23036 T23036 ROOT probed,probed
R18466 T23037 T23036 prep with,probed
R18467 T23038 T23039 amod specific,antibodies
R18468 T23039 T23037 pobj antibodies,with
R18469 T23040 T23041 mark as,described
R18470 T23041 T23042 amod described,previously46
R18471 T23042 T23036 dobj previously46,probed
R18472 T23043 T23036 punct .,probed
R18473 T23044 T23046 nsubjpass Bands,imaged
R18474 T23045 T23046 auxpass were,imaged
R18475 T23046 T23046 ROOT imaged,imaged
R18476 T23047 T23046 agent by,imaged
R18477 T23048 T23051 det the,system
R18478 T23049 T23051 compound Super,system
R18479 T23050 T23051 compound Signaling,system
R18480 T23051 T23047 pobj system,by
R18481 T23052 T23051 punct (,system
R18482 T23053 T23051 appos Pierce,system
R18483 T23054 T23051 punct ),system
R18484 T23055 T23046 prep according,imaged
R18485 T23056 T23055 prep to,according
R18486 T23057 T23058 det the,manufacturer
R18487 T23058 T23060 poss manufacturer,instructions
R18488 T23059 T23058 case 's,manufacturer
R18489 T23060 T23056 pobj instructions,to
R18490 T23061 T23046 punct .,imaged
R223 T289 T265 punct .,is
R224 T290 T293 advmod However,is
R225 T291 T293 punct ",",is
R226 T292 T293 nsubj it,is
R227 T293 T293 ROOT is,is
R493 T250 T251 compound IKKβ,phosphorylation
R494 T251 T252 nsubj phosphorylation,regulates
R495 T252 T252 ROOT regulates,regulates
R496 T253 T255 nummod RPS3,translocation
R497 T254 T255 amod nuclear,translocation
R498 T255 T258 nmod translocation,function
R499 T256 T255 cc and,translocation
R500 T257 T258 compound NF-κB,function
R501 T258 T252 dobj function,regulates
R502 T259 T260 compound during Escherichia,coli O157
R503 T260 T252 npadvmod coli O157,regulates
R504 T261 T260 punct :,coli O157
R505 T262 T264 compound H7,NF-κB
R218 T284 T285 nsubj that,directs
R219 T285 T283 relcl directs,subunit
R220 T286 T288 amod specific,transcription
R221 T287 T288 compound gene,transcription
R18662 T23315 T23314 prep staining,immunohistochemical
R18663 T23316 T23314 advcl using,immunohistochemical
R18664 T23317 T23318 amod phospho-RPS3,antibody
R18665 T23318 T23316 dobj antibody,using
R18666 T23319 T23320 auxpass were,performed
R18667 T23320 T23320 ROOT performed,performed
R18668 T23321 T23320 agent by,performed
R18669 T23322 T23323 compound Histoserv,Inc.
R18670 T23323 T23321 pobj Inc.,by
R6542 T8088 T8088 ROOT observed,observed
R6543 T8089 T8100 mark that,eliminated
R6544 T8090 T8100 nsubjpass overexpressing,eliminated
R6545 T8091 T8094 nmod IKKβ,phosphorylation
R6546 T8092 T8094 amod enhanced,phosphorylation
R6547 T8093 T8094 compound Flag-RPS3,phosphorylation
R6548 T8094 T8090 dobj phosphorylation,overexpressing
R6549 T8095 T8090 punct ",",overexpressing
R6550 T8096 T8090 cc but,overexpressing
R6551 T8097 T8100 nsubjpass phosphorylation,eliminated
R6552 T8098 T8100 auxpass was,eliminated
R6553 T8099 T8100 advmod effectively,eliminated
R6554 T8100 T8088 ccomp eliminated,observed
R6555 T8101 T8100 agent by,eliminated
R6556 T8102 T8103 amod alanine,substitution
R6557 T8103 T8101 pobj substitution,by
R6558 T8104 T8100 advcl indicating,eliminated
R6559 T8105 T8107 mark that,is
R10422 T12845 T12846 amod RPS3-independent,genes
R12760 T15858 T15863 advmod Thus,required
R12761 T15859 T15861 amod NleH1,activity
R12762 T15860 T15861 compound kinase,activity
R12763 T15861 T15863 nsubjpass activity,required
R15621 T19398 T19399 nsubj that,influence
R15622 T19399 T19397 relcl influence,effects
R15623 T19400 T19401 det the,spread
R15624 T19401 T19399 dobj spread,influence
R15625 T19402 T19401 prep of,spread
R15626 T19403 T19402 pobj disease,of
R15627 T19404 T19407 auxpass are,understood
R15628 T19405 T19407 advmod often,understood
R15629 T19406 T19407 advmod poorly,understood
R15630 T19407 T19407 ROOT understood,understood
R15631 T19408 T19407 prep at,understood
R15632 T19409 T19411 det the,level
R15633 T19410 T19411 amod molecular,level
R222 T288 T285 dobj transcription,directs
R3334 T4143 T4144 nsubj activity,is
R3335 T4144 T4144 ROOT is,is
R3336 T4145 T4144 acomp necessary,is
R3337 T4146 T4145 cc and,necessary
R3338 T4147 T4145 conj sufficient,necessary
R3339 T4148 T4147 prep for,sufficient
R3340 T4149 T4151 amod RPS3,translocation
R3341 T4150 T4151 amod nuclear,translocation
R3342 T4151 T4148 pobj translocation,for
R4571 T5692 T5689 conj stimulated,enhanced
R4572 T5693 T5692 dobj cells,stimulated
R4573 T5694 T5696 punct (,3a
R4574 T5695 T5696 compound Fig.,3a
R4575 T5696 T5693 appos 3a,cells
R4576 T5697 T5693 punct ),cells
R4577 T5698 T5689 punct .,enhanced
R4578 T5699 T5702 advmod Therefore,examined
R4579 T5700 T5702 punct ",",examined
R4580 T5701 T5702 nsubj we,examined
R4581 T5702 T5702 ROOT examined,examined
R4582 T5703 T5705 mark whether,binding
R4583 T5704 T5705 nsubj RPS3,binding
R4636 T5757 T5758 nsubj We,measured
R4637 T5758 T5758 ROOT measured,measured
R4638 T5759 T5760 det the,association
R4639 T5760 T5758 dobj association,measured
R4640 T5761 T5760 prep of,association
R4641 T5762 T5761 pobj RPS3,of
R4642 T5763 T5762 prep with,RPS3
R4643 T5764 T5763 pobj importin-α,with
R4644 T5765 T5764 prep in,importin-α
R4645 T5766 T5767 amod 293T,cells
R4646 T5767 T5765 pobj cells,in
R4647 T5768 T5758 advcl overexpressing,measured
R4648 T5769 T5770 compound wild-type,IκBα
R4649 T5770 T5768 dobj IκBα,overexpressing
R6464 T8010 T8011 compound CK2,protein
R6465 T8011 T8012 nsubj protein,was
R6466 T8012 T8012 ROOT was,was
R6467 T8013 T8012 acomp detectable,was
R6468 T8014 T8013 prep in,detectable
R6469 T8015 T8018 poss our,proteins
R6470 T8016 T8018 amod recombinant,proteins
R6471 T8017 T8018 compound IKK,proteins
R6472 T8018 T8014 pobj proteins,in
R6473 T8019 T8021 punct (,Fig.
R6474 T8020 T8021 compound Supplementary,Fig.
R6475 T8021 T8013 appos Fig.,detectable
R6476 T8022 T8021 nummod 6,Fig.
R6477 T8023 T8021 punct ),Fig.
R6478 T8024 T8012 punct .,was
R6479 T8025 T8030 advmod Thus,was
R6480 T8026 T8030 punct ",",was
R6481 T8027 T8029 compound RPS3,phosphorylation
R6482 T8028 T8029 compound S209,phosphorylation
R6483 T8029 T8030 nsubj phosphorylation,was
R6484 T8030 T8030 ROOT was,was
R6485 T8031 T8030 acomp due,was
R6486 T8032 T8031 prep to,due
R6487 T8033 T8035 det the,specificity
R6488 T8034 T8035 amod alternate,specificity
R6489 T8035 T8032 pobj specificity,to
R6490 T8036 T8035 prep of,specificity
R6491 T8037 T8039 det the,kinase
R6492 T8038 T8039 compound IKKβ,kinase
R6493 T8039 T8036 pobj kinase,of
R6494 T8040 T8041 advmod rather,than
R6495 T8041 T8039 cc than,kinase
R6496 T8042 T8044 det any,amount
R6497 T8043 T8044 compound trace,amount
R6498 T8044 T8031 pobj amount,due
R6499 T8045 T8044 prep of,amount
R6500 T8046 T8045 pobj CK2,of
R8203 T10147 T10148 amod RPS3,deficiency
R8204 T10148 T10146 pobj deficiency,by
R8205 T10149 T10151 auxpass was,restored
R8206 T10150 T10151 advmod completely,restored
R8207 T10151 T10151 ROOT restored,restored
R8208 T10152 T10151 prep by,restored
R8209 T10153 T10152 pcomp transfecting,by
R8210 T10154 T10153 dobj wild-type,transfecting
R8211 T10155 T10151 punct ",",restored
R8212 T10156 T10151 cc but,restored
R8213 T10157 T10158 neg not,by
R8214 T10158 T10151 conj by,restored
R8215 T10159 T10160 compound S209A,RPS3
R8216 T10160 T10158 pobj RPS3,by
R8217 T10161 T10162 punct (,Fig.
R8218 T10162 T10160 appos Fig.,RPS3
R8219 T10163 T10162 nummod 5d,Fig.
R8220 T10164 T10160 punct ),RPS3
R8221 T10165 T10158 punct ",",by
R8222 T10166 T10158 conj despite,by
R8223 T10167 T10168 amod equivalent,expression
R8224 T10168 T10166 pobj expression,despite
R8225 T10169 T10170 punct (,Fig.
R8226 T10170 T10168 appos Fig.,expression
R8227 T10171 T10170 nummod 5c,Fig.
R8228 T10172 T10166 punct ),despite
R8229 T10173 T10151 punct .,restored
R15634 T19411 T19408 pobj level,at
R15635 T19412 T19407 punct .,understood
R15636 T19413 T19414 poss Our,data
R15637 T19414 T19415 nsubj data,elucidate
R15638 T19415 T19415 ROOT elucidate,elucidate
R15639 T19416 T19436 advmod how,influence
R15640 T19417 T19436 dep alterations,influence
R15641 T19418 T19417 prep in,alterations
R15642 T19419 T19421 amod selective,function
R15643 T19420 T19421 compound NF-κB,function
R15644 T19421 T19418 pobj function,in
R15645 T19422 T19421 punct ",",function
R15646 T19423 T19421 acl achieved,function
R15647 T19424 T19423 prep by,achieved
R15648 T19425 T19424 pcomp impeding,by

UBERON-AE

Id Subject Object Predicate Lexical cue
T728 2664-2668 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T7049 10480-10489 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms
T7050 12059-12063 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T11828 16005-16015 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11829 16005-16026 http://purl.obolibrary.org/obo/UBERON_0001277 denotes intestinal epithelial
T13726 19142-19148 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colons
T20200 28315-28320 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T22539 34604-34608 http://purl.obolibrary.org/obo/UBERON_0001913 denotes milk
T22540 34902-34907 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T23238 35570-35575 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

GO-BP

Id Subject Object Predicate Lexical cue
T1583 988-996 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T1584 1053-1066 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1585 1951-1964 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1586 1569-1579 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1587 2457-2467 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1588 1665-1680 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1589 1718-1737 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T1590 1867-1876 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T1591 1951-1979 http://purl.obolibrary.org/obo/GO_0031555 denotes transcription by attenuating
T1592 2071-2087 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activating
T1593 2528-2544 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T1594 2071-2095 http://purl.obolibrary.org/obo/GO_1901224 denotes NF-κB activating signals
T1595 2088-2095 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T1596 2820-2835 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T1597 3082-3104 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T1598 3082-3104 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T1599 3082-3104 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T1600 3082-3104 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T1601 3082-3104 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T1602 3082-3104 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T1603 3089-3104 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T2351 3131-3146 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2352 3676-3691 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2353 3787-3802 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2354 3869-3884 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2355 4008-4023 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2356 3290-3298 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T2357 3290-3298 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T2358 3290-3298 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T2359 3290-3298 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T3039 4074-4107 http://purl.obolibrary.org/obo/GO_1903721 denotes activation of the inhibitor of κB
T3040 4116-4119 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3041 4225-4240 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3042 4913-4928 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3043 4715-4728 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3044 4742-4760 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T4265 5278-5295 http://purl.obolibrary.org/obo/GO_0007097 denotes nuclear migration
T4266 6681-6697 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activating
T6175 6713-6724 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6176 7311-7322 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6177 7464-7475 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6178 7683-7694 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6179 8479-8490 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6180 8687-8698 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6181 8880-8891 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6182 9074-9085 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6183 6781-6795 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T6184 6848-6860 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T6185 6861-6867 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T6186 8782-8788 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T6187 9223-9229 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T6188 7214-7235 http://purl.obolibrary.org/obo/GO_0005049 denotes binding to importin-α
T6189 7282-7298 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T6190 8765-8781 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T6191 7663-7678 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6192 9054-9069 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6193 9248-9263 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6194 8502-8505 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6195 8765-8788 http://purl.obolibrary.org/obo/GO_1901224 denotes NF-κB activation signal
T6196 8843-8860 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T6197 8851-8860 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T8269 9485-9488 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8270 9636-9639 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8271 11005-11008 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8272 11255-11258 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8273 10520-10526 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T8274 10520-10534 http://purl.obolibrary.org/obo/GO_0007165 denotes signal pathway
T8275 10805-10820 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8276 10859-10874 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8277 11175-11190 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8278 11308-11323 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8279 11689-11704 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8280 11710-11725 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8281 11838-11853 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10669 12116-12131 http://purl.obolibrary.org/obo/GO_0016310 denotes Phosphorylation
T10670 12193-12208 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10671 13023-13038 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10672 13140-13155 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10673 14230-14245 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10677 13059-13075 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10678 14479-14495 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10679 12397-12415 http://purl.obolibrary.org/obo/GO_0006986 denotes heat-shock protein
T10680 12397-12415 http://purl.obolibrary.org/obo/GO_0034620 denotes heat-shock protein
T10681 12397-12415 http://purl.obolibrary.org/obo/GO_0042026 denotes heat-shock protein
T10682 13751-13757 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T10683 13956-13975 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T10684 13956-13975 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T10685 13956-13975 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T10686 13956-13975 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T10687 13956-13975 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T10688 14006-14017 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T10689 15277-15292 http://purl.obolibrary.org/obo/GO_0072606 denotes IL-8) secretion
T10690 15277-15292 http://purl.obolibrary.org/obo/GO_2000482 denotes IL-8) secretion
T10691 15283-15292 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T10692 15328-15331 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T13010 15817-15832 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13011 16328-16343 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13012 16555-16570 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13013 16830-16845 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13014 17117-17132 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13015 17190-17205 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13016 17324-17339 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13017 17581-17596 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13018 17738-17753 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13019 17838-17853 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13020 18433-18448 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13021 16054-16067 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibit NF-κB
T13022 16054-16067 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibit NF-κB
T13023 16431-16447 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T13024 16676-16679 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T13025 16699-16710 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T13026 17924-17937 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13027 18386-18401 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T14164 18541-18556 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T14165 19031-19046 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T14166 19535-19550 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T14167 18830-18851 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T16692 19849-19864 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16693 20346-20361 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16694 20489-20504 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16695 20807-20822 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16696 20963-20978 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16697 21016-21031 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16698 21118-21133 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16699 21484-21499 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16700 21556-21571 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16701 21681-21696 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16702 22748-22763 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16703 22958-22973 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16704 23512-23527 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16705 23593-23608 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16706 23700-23715 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16707 23881-23896 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T16708 20115-20130 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16709 20426-20441 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16710 21268-21283 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16711 21634-21649 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16712 20715-20734 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T16713 20715-20734 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T16714 20715-20734 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T16715 20715-20734 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T16716 20715-20734 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T16717 22467-22482 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T16718 22473-22482 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T16719 23258-23261 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T16720 23425-23428 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T16721 23619-23622 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T16722 23969-23991 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T16723 23969-23991 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T16724 23969-23991 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T16725 23969-23991 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T16726 23969-23991 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T16727 23969-23991 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T16728 23976-23991 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T19593 24147-24163 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T19594 25572-25588 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T19595 24147-24173 http://purl.obolibrary.org/obo/GO_1901224 denotes NF-κB activation signaling
T19596 25572-25598 http://purl.obolibrary.org/obo/GO_1901224 denotes NF-κB activation signaling
T19597 24164-24173 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19598 25589-25598 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19599 25797-25806 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19600 26147-26156 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19601 26514-26523 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19602 26587-26596 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T19603 24297-24312 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19604 24740-24755 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19605 24870-24885 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19606 25195-25210 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19607 25459-25474 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19608 25711-25726 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19609 26029-26044 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19610 26278-26293 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19611 24364-24378 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T19612 24619-24622 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19613 25362-25365 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19614 25421-25424 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19615 24992-25005 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T19616 26760-26773 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T19617 25635-25647 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T19618 25791-25806 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T19619 26141-26156 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T19620 26508-26523 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T19621 26581-26596 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T19622 26214-26229 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T19623 26745-26773 http://purl.obolibrary.org/obo/GO_0031555 denotes attenuates the transcription
T20447 28838-28850 http://purl.obolibrary.org/obo/GO_0009293 denotes Transduction
T21326 30656-30659 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T21520 31336-31345 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T21676 31430-31434 http://purl.obolibrary.org/obo/GO_0016246 denotes RNAi
T23071 34039-34050 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T23072 34463-34468 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T432 5-20 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T433 369-384 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T434 598-613 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T435 165-181 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T436 261-274 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T437 435-447 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T438 541-550 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T439 541-550 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T10674 14382-14397 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10675 15683-15698 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10676 12266-12282 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation

GO-MF

Id Subject Object Predicate Lexical cue
T440 186-203 http://purl.obolibrary.org/obo/GO_0003735 denotes ribosomal protein
T1604 1294-1311 http://purl.obolibrary.org/obo/GO_0003735 denotes ribosomal protein
T1605 1471-1482 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T1606 1475-1482 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1607 2220-2227 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1608 1636-1650 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T1609 2220-2231 http://purl.obolibrary.org/obo/GO_0003723 denotes binding RNA
T2360 3701-3711 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3045 4116-4119 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6198 7214-7221 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6199 7214-7235 http://purl.obolibrary.org/obo/GO_0005049 denotes binding to importin-α
T6200 8502-8505 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8282 9485-9488 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8283 9636-9639 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8284 11005-11008 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8285 11255-11258 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8286 11903-11911 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T13028 16676-16679 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T14168 19228-19236 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T16729 20115-20130 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16730 20426-20441 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16731 21268-21283 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16732 21634-21649 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity
T16733 20715-20734 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T16734 20715-20734 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T16735 20715-20734 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T20448 28480-28490 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T20449 28643-28653 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T20450 28737-28747 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T20451 28814-28824 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T20452 28924-28934 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T20453 29032-29042 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T20454 29153-29161 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T20969 30237-30245 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T21327 30656-30659 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22528 33479-33489 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T22529 33550-33560 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T23073 34039-34050 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T23074 34317-34325 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T23075 34661-34671 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T23076 34989-34999 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T23175 35151-35155 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T23328 35711-35719 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T10694 13956-13975 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T10695 13956-13975 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T10696 13956-13975 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T10697 13956-13975 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T10698 13956-13975 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T10699 15274-15279 http://purl.obolibrary.org/obo/GO_0005153 denotes 8 (IL
T16736 20715-20734 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T16737 20715-20734 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T16738 23258-23261 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T16739 23425-23428 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T16740 23619-23622 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19624 24619-24622 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19625 25362-25365 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19626 25421-25424 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19627 26214-26229 http://purl.obolibrary.org/obo/GO_0016301 denotes kinase activity

GO-CC

Id Subject Object Predicate Lexical cue
T2362 3394-3399 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2363 3636-3641 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2364 3701-3711 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T2365 3701-3711 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T3046 4600-4605 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3047 4742-4746 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4267 5386-5391 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4268 5979-5984 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4269 6268-6273 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4270 6356-6361 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4271 6421-6426 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4272 6505-6510 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4273 6345-6361 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus in cells
T6201 7161-7166 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6202 7576-7581 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6203 7699-7704 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6204 7845-7850 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6205 8259-8264 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6206 8421-8426 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8287 11522-11527 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8288 11618-11623 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8289 11903-11911 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8290 11903-11911 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T10700 12361-12366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10701 14108-14113 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13029 16864-16869 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13030 17024-17029 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13031 17053-17058 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13032 17236-17241 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13033 17358-17363 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13034 18025-18030 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13035 18101-18106 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14169 18957-18961 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14170 19228-19236 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T14171 19228-19236 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T16741 20268-20273 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16742 20831-20836 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16743 20897-20902 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16744 21152-21157 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16745 22134-22139 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16746 22333-22338 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16747 22454-22459 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16748 22600-22605 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16749 23964-23968 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19639 25888-25893 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19640 26384-26389 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20455 28240-28245 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20456 28945-28949 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T20457 28480-28490 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T20458 28643-28653 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T20459 28737-28747 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T20460 28814-28824 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T20461 28924-28934 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T20462 29032-29042 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T20463 29153-29161 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T20464 28480-28490 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20465 28643-28653 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20466 28737-28747 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20467 28814-28824 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20468 28924-28934 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20469 29032-29042 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T20470 29153-29161 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T20970 29954-29959 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20971 30166-30170 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T20972 30237-30245 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T20973 30237-30245 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T21677 31725-31730 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21678 31740-31745 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22029 31906-31911 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22186 32624-32629 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22302 32949-32958 http://purl.obolibrary.org/obo/GO_0000785 denotes Chromatin
T22530 33268-33273 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22531 33367-33372 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22532 33479-33489 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T22533 33550-33560 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T22534 33479-33489 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T22535 33550-33560 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T23077 33780-33785 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23078 34317-34325 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T23079 34661-34671 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T23080 34989-34999 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T23081 34317-34325 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T23082 34661-34671 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T23083 34989-34999 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T23084 34567-34576 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T23085 34811-34820 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T23176 35202-35206 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T23236 35340-35344 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T23237 35361-35366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T23329 35711-35719 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T23330 35711-35719 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T1610 1758-1762 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1611 2243-2264 http://purl.obolibrary.org/obo/GO_0022627 denotes 40S ribosomal subunit
T1612 2247-2264 http://purl.obolibrary.org/obo/GO_0044391 denotes ribosomal subunit
T2361 3332-3337 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10702 14515-14520 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10703 15631-15636 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10704 14326-14335 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T10705 14462-14471 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T10706 15328-15331 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10707 15538-15550 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T19628 24244-24251 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T19629 25786-25790 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19630 25883-25887 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19631 26379-26383 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19632 26503-26507 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19633 26576-26580 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19634 27154-27158 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19635 27342-27346 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19636 27510-27514 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T19637 25883-25893 http://purl.obolibrary.org/obo/GO_0043657 denotes host cells
T19638 26379-26389 http://purl.obolibrary.org/obo/GO_0043657 denotes host cells

sentences

Id Subject Object Predicate Lexical cue
T779 939-1134 Sentence denotes Nuclear Factor-kappa B (NF-κB) regulates crucial cellular functions and diverse stimuli activate this pleiotropic transcription factor, which in turn regulates a vast array of genetic targets1-3.
T780 1135-1247 Sentence denotes The best-known mammalian NF-κB subunits are Rel proteins, including RelA (p65), RelB, c-Rel, p50, and p52 (refs.
T781 1248-1254 Sentence denotes 4, 5).
T782 1255-1382 Sentence denotes However, we recently demonstrated that ribosomal protein S3 (RPS3) is a key non-Rel subunit of certain native NF-κB complexes6.
T783 1383-1563 Sentence denotes RPS3 is defined as a “specifier” subunit of NF-κB, because it facilitates high affinity DNA binding thus determining the regulatory specificity of NF-κB for selected target genes7.
T784 1564-1822 Sentence denotes RPS3 regulation of NF-κB governs key physiological processes, including immunoglobulin κ light chain gene expression and receptor editing in B cells6, 8, cytokine production in T cells6, and in host defense against enterohemorrhagic Escherichia coli (EHEC)9.
T785 1823-2044 Sentence denotes In particular, the E. coli O157:H7 type III secretion system (T3SS) effector protein NleH1 selectively blocks NF-κB target gene transcription by attenuating RPS3 nuclear translocation, without affecting p65 localization9.
T786 2045-2211 Sentence denotes Nonetheless, how specific NF-κB activating signals induce RPS3 nuclear translocation is unknown. Extra-ribosomal functions have been ascribed to ribosomal proteins10.
T787 2212-2337 Sentence denotes Besides binding RNA within the 40S ribosomal subunit, RPS3 participates in transcription6, DNA repair11, 12, and apoptosis13.
T788 2338-2404 Sentence denotes Whether or not RPS3 is phosphorylated had been controversial14-18.
T789 2405-2593 Sentence denotes Since kinase cascades play a critical role in NF-κB regulation, we tested whether RPS3 is phosphorylated in the context of NF-κB activation and sought to identify the responsible kinase19.
T790 2594-2809 Sentence denotes Additionally, we aimed to define a regulatory role for the C-terminal tail of RPS3 whose function was unknown. Here we show that the Inhibitor of κB (IκB) kinase beta (IKKβ) phosphorylated RPS3 at serine 209 (S209).
T791 2810-2954 Sentence denotes RPS3 S209 phosphorylation enhanced its association with importin-α, mediating RPS3 entry into the karyopherin pathway for nuclear translocation.
T792 2955-3115 Sentence denotes Furthermore, the E. coli NleH1 effector specifically inhibited RPS3 S209 revealing how E. coli O157:H7 inhibits this important innate immune response mechanism.
T2011 3126-3178 Sentence denotes RPS3 phosphorylation in response to NF-κB activation
T2012 3179-3338 Sentence denotes To test whether RPS3 is phosphorylated during NF-κB activation, we performed 32P-labeling experiments in tumor necrosis factor (TNF)-stimulated HEK 293T cells.
T2013 3339-3520 Sentence denotes While RPS3 was scarcely phosphorylated in unstimulated cells, we observed a marked increase in 32P-incorporation after TNF stimulation despite no increase in RPS3 protein (Fig. 1a).
T2014 3521-3712 Sentence denotes To determine which RPS3 residues were phosphorylated, we immunoprecipitated RPS3 from either resting or stimulated cells and performed immunoblotting with phosphorylation-specific antibodies.
T2015 3713-3966 Sentence denotes Both TNF and phorbol myristate acetate/ionomycin (PMA+I) stimulated rapid phosphorylation and degradaion of IκBα within 5 min which was accompanied by RPS3 phosphorylation on serine residues (Fig. 1b and data not shown), similar to the in vivo labeling.
T2016 3967-4042 Sentence denotes We did not detect tyrosine- or threonine-phosphorylation of RPS3 (Fig. 1b).
T2634 4044-4069 Sentence denotes RPS3 and IKKβ interaction
T2635 4070-4310 Sentence denotes The activation of the inhibitor of κB kinase (IKK), consisting of a regulatory subunit IKKγ and two catalytic subunits, IKKα and IKKβ, is critical for the phosphorylation and dispatch of the inhibitory IκBs and the liberation of NF-κB20-22.
T2636 4311-4488 Sentence denotes Given that RPS3 can be found in the cytoplasmic p65-p50-IκBα inhibitory complex in resting cells6, we hypothesized that activated IKKβ might also bind to and phosphorylate RPS3.
T2637 4489-4567 Sentence denotes First, we found that ectopically expressed IKKβ and RPS3 interacted (Fig. 1c).
T2638 4568-4774 Sentence denotes We next examined resting Jurkat cells and detected a modest endogenous IKKβ-RPS3 interaction (Fig. 1d), potentially accounting for the basal NF-κB transcription required for cell proliferation and survival.
T2639 4775-4939 Sentence denotes RPS3-IKKβ association was clearly augmented upon TNF stimulation, peaking at 10 min. (Fig. 1d), following similar kinetics to RPS3 serine phosphorylation (Fig. 1b).
T2640 4940-5021 Sentence denotes By contrast, there was no detectable interaction between RPS3 and IKKα (Fig. 1d).
T3532 5023-5070 Sentence denotes IKKβ is required for RPS3 nuclear translocation
T3533 5071-5319 Sentence denotes To examine whether the RPS3-IKKβ interaction is required for RPS3 nuclear translocation, we knocked down IKKα or IKKβ expression with siRNAs (Supplementary Fig. 1) and then observed stimulation-induced RPS3 nuclear migration by confocal microscopy.
T3534 5320-5455 Sentence denotes Both TNF and PMA+I triggered RPS3 nuclear translocation in Jurkat cells transfected with a scrambled nonspecific (NS) siRNA (Fig. 2a)6.
T3535 5456-5540 Sentence denotes RPS3 nuclear translocation was only slightly, if at all, impaired by IKKα-silencing.
T3536 5541-5650 Sentence denotes Conversely, knockdown of IKKβ attenuated 60-70% of RPS3 nuclear accumulation following stimulation (Fig. 2a).
T3537 5651-5815 Sentence denotes Immunoblotting of nuclear fractions confirmed that full expression of IKKβ, but not IKKα, was necessary for activation-induced RPS3 nuclear translocation (Fig. 2b).
T3538 5816-5924 Sentence denotes Control immunoblots revealed that p65 nuclear translocation was blocked under the same conditions (Fig. 2b).
T3539 5925-6087 Sentence denotes We next examined the nuclear translocation of RPS3 in cells ectopically expressing either kinase-dead (SSAA) or constitutively-active (SSEE) mutant IKKβ proteins.
T3540 6088-6209 Sentence denotes As expected, the SSEE, but not SSAA, mutant of IKKβ induced NF-κB-dependent luciferase reporter activity (Fig. 2c, left).
T3541 6210-6402 Sentence denotes Whereas RPS3 remained cytosolic in IKKβ (SSAA)-expressing cells (Fig. 2c, right), a substantial proportion of RPS3 translocated to the nucleus in cells expressing IKKβ (SSEE) (Fig. 2c, right).
T3542 6403-6586 Sentence denotes The percentage of cells containing detectable nuclear RPS3 increased 5-fold in IKKβ (SSEE)-expressing cells, but not in IKKβ (SSAA)-expressing ones (Fig. 2d and Supplementary Fig. 2).
T3543 6587-6706 Sentence denotes Thus, IKKβ activity is necessary and sufficient for RPS3 nuclear translocation in response to NF-κB activating stimuli.
T5142 6708-6755 Sentence denotes IκBα degradation and RPS3 nuclear translocation
T5143 6756-6824 Sentence denotes Importin-α regulates the nuclear import of NF-κB Rel subunits23, 24.
T5144 6825-6977 Sentence denotes RPS3 harbors a nuclear localization signal (NLS) sequence and its nuclear translocation occurs in parallel to, but independently of, p65 translocation6.
T5145 6978-7046 Sentence denotes We envisioned that RPS3 could also utilize the importin-α/β pathway.
T5146 7047-7177 Sentence denotes Consistent with this notion, RPS3 association with importin-α, but not importin-β, was enhanced in TNF–stimulated cells (Fig. 3a).
T5147 7178-7299 Sentence denotes Therefore, we examined whether RPS3 binding to importin-α is essential for nuclear translocation during NF-κB activation.
T5148 7300-7515 Sentence denotes Since IκBα degradation is a prerequisite to unmask the NLS of p65, and both RPS3 and IκBα bind to p65 in the cytoplasmic inhibitory complex, we tested whether IκBα degradation is required for the liberation of RPS3.
T5149 7516-7695 Sentence denotes We measured the association of RPS3 with importin-α in 293T cells overexpressing wild-type IκBα or an IκBα mutant (SSAA) resistant to IKKβ-induced phosphorylation and degradation.
T5150 7696-7851 Sentence denotes In cells transfected with wild-type IκBα, TNF stimulation augmented the interaction of RPS3 and importin-α to a similar degree as in non-transfected cells.
T5151 7852-7977 Sentence denotes By contrast, we observed that the RPS3-importin-α association was abolished by the presence of non-degradable IκBα (Fig. 3b).
T5152 7978-8166 Sentence denotes To examine whether IκBα is the only cytoplasmic barrier precluding RPS3 nuclear translocation, we measured both RPS3-importin-α association and nuclear RPS3 after reducing IκBα expression.
T5153 8167-8282 Sentence denotes Compared with nonspecific siRNA, siRNA targeting of IκBα completely depleted IκBα in Jurkat cells (Fig. 3c, input).
T5154 8283-8410 Sentence denotes Nevertheless, the RPS3-importin-α association was not augmented (Fig. 3c), nor was significant nuclear RPS3 detected (Fig. 3d).
T5155 8411-8723 Sentence denotes Moreover, cells treated with sodium pervanadate (Pv) to induce IκBα degradation through an IKK-independent mechanism25-27 did not show increased association between RPS3 and importin-α (Fig. 3e and Supplementary Fig. 3b) or nuclear accumulation of RPS3, despite complete IκBα degradation (Supplementary Fig. 3c).
T5156 8724-8892 Sentence denotes We further examined whether a subsequent NF-κB activation signal independently promotes the importin-α association and nuclear transport of RPS3 after IκBα degradation.
T5157 8893-9042 Sentence denotes We found that TNF stimulation following Pv treatment was required for the RPS3-importin-α association, comparable to TNF stimulation alone (Fig. 3e).
T5158 9043-9200 Sentence denotes Thus, IκBα phosphorylation and degradation itself is required but not sufficient to cause RPS3 association with importin-α followed by nuclear translocation.
T5159 9201-9285 Sentence denotes Rather, an additional signal, potentially IKKβ phosphorylation of RPS3, is required.
T7141 9287-9325 Sentence denotes IKKβ phosphorylates RPS3 at serine 209
T7142 9326-9520 Sentence denotes Although originally defined as the kinase that phosphorylates IκB19, IKKβ also phosphorylates unrelated substrates including 14-3-3β and Bcl10, which lack the IKK consensus motif (DpSGYXpS/T)28.
T7143 9521-9591 Sentence denotes We therefore hypothesized that IKKβ could directly phosphorylate RPS3.
T7144 9592-9910 Sentence denotes By in vitro kinase assays using recombinant IKK and RPS3 proteins, we observed strong incorporation of 32P in autophosphorylatd IKKα and IKKβ (Fig. 4a, lanes 2-7) as well as phosporylated GST-IκBα (1-54) (Supplementary Fig. 4), but not the GST protein alone (Fig. 4a, lanes 3 and 6), when either IKKα or IKKβ was used.
T7145 9911-10028 Sentence denotes We discovered that GST-RPS3 could be phosphorylated by IKKβ, but not IKKα, in vitro (Fig. 4a, compare lanes 4 and 7).
T7146 10029-10200 Sentence denotes To identify the RPS3 amino acid residue(s) phosphorylated by IKKβ, we performed liquid chromatography-tandem mass spectrometry analyses using in vitro phosphorylated RPS3.
T7147 10201-10295 Sentence denotes The results indicated that IKKβ phosphorylated S209, located in the RPS3 C-terminus (Fig. 4b).
T7148 10296-10558 Sentence denotes RPS3 amino acid sequence alignment revealed that S209 is conserved in many species throughout phylogeny with the exception of Caenorhabditis elegans and Schizosaccharomyces pombe, two organisms that do not possess the NF-κB signal pathway (Supplementary Fig. 5).
T7149 10559-10721 Sentence denotes To verify biochemically that S209 is an IKKβ substrate, we performed 32P-labeling in vitro kinase assays with recombinant wild-type or S209A mutant RPS3 proteins.
T7150 10722-10831 Sentence denotes Compared with the wild-type protein, the S209A mutation reduced IKKβ–mediated RPS3 phosphorylation (Fig. 4c).
T7151 10832-10958 Sentence denotes There might be alternative phosphorylation site(s) under these conditions given modest residual phosphorylated RPS3 (Fig. 4c).
T7152 10959-11130 Sentence denotes RPS3 S209 does not fall within a conventional IKK recognition motif, but rather resides in a sequence motif (XXXpS/TXXE), potentially recognized by casein kinase II (CK2).
T7153 11131-11291 Sentence denotes Although IKKβ kinase can display a CK2-like phosphorylation specificity29, no CK2 protein was detectable in our recombinant IKK proteins (Supplementary Fig. 6).
T7154 11292-11430 Sentence denotes Thus, RPS3 S209 phosphorylation was due to the alternate specificity of the IKKβ kinase rather than any trace amount of CK2 bound to IKKs.
T7155 11431-11624 Sentence denotes To determine whether S209 is the critical site at which IKKβ phosphorylates RPS3 in living cells, we transfected the wild-type or S209A mutant Flag-RPS3 alone, or together with IKKβ into cells.
T7156 11625-11864 Sentence denotes Indeed, we observed that overexpressing IKKβ enhanced Flag-RPS3 phosphorylation, but phosphorylation was effectively eliminated by alanine substitution indicating that S209 is the predominant target site for IKKβ phosphorylation (Fig. 4d).
T7157 11865-12032 Sentence denotes We next generated a phospho-S209 RPS3 antibody and confirmed that endogenous RPS3 was phosphorylated at S209 in a time-dependent manner upon TNF stimulation (Fig. 4e).
T7158 12033-12114 Sentence denotes Thus, the RPS3 C-terminal tail potentially contains an important regulatory site.
T9155 12116-12162 Sentence denotes Phosphorylation of RPS3 and its NF-κB function
T9156 12163-12283 Sentence denotes We next examined whether S209 phosphorylation plays a role in the nuclear translocation of RPS3 during NF-κB activation.
T9157 12284-12551 Sentence denotes Subcellular fractions from either wild-type or S209A mutant RPS3-transfected cells were prepared and blotted for heat-shock protein 90 (hsp90), a cytoplasmic protein, and poly (ADP-ribose) polymerase (PARP), a nuclear protein, confirming a clean separation (Fig. 5a).
T9158 12552-12645 Sentence denotes As expected, PMA+I stimulation triggered wild-type Flag-RPS3 nuclear translocation (Fig. 5a).
T9159 12646-12715 Sentence denotes However, RPS3 (S209A) nuclear translocation was attenuated (Fig. 5a).
T9160 12716-12815 Sentence denotes We also tested the impact of activating NF-κB by overexpressing IKKβ on RPS3 nuclear translocation.
T9161 12816-12993 Sentence denotes IKKβ overexpression activated NF-κB measured by luciferase assays (Supplementary Fig. 7), and also induced the nuclear translocation of wild-type, but not S209A, RPS3 (Fig. 5b).
T9162 12994-13111 Sentence denotes These data suggest that S209 phosphorylation is critical for the NF-κB activation-induced RPS3 nuclear translocation.
T9163 13112-13400 Sentence denotes To examine the role of S209 phosphorylation of RPS3 to its NF-κB function6, 7, 30, we silenced endogenous RPS3 expression using an siRNA that targets the 3′ untranslated region (3′ UTR) of RPS3 mRNA, followed by complementation with either wild-type or S209A mutant RPS3 via transfection.
T9164 13401-13609 Sentence denotes As expected, RPS3 siRNA severely reduced endogenous RPS3 abundance compared to NS siRNA, but did not affect the robust expression of Flag-tagged RPS3 from a transfected construct lacking the 3′ UTR (Fig. 5c).
T9165 13610-13726 Sentence denotes We also found that RPS3 knockdown reduced TNF-induced expression of an Ig κB-driven luciferase construct6 (Fig. 5d).
T9166 13727-13908 Sentence denotes The impaired luciferase signal caused by RPS3 deficiency was completely restored by transfecting wild-type, but not by S209A RPS3 (Fig. 5d), despite equivalent expression (Fig. 5c).
T9167 13909-14179 Sentence denotes Moreover, the failure of S209A RPS3 to restore luciferase activity did not result from defective translation because the transient overexpression of green fluorescent protein (GFP) was comparable in cells complemented with wild-type or S029A RPS3 (Supplementary Fig. 8).
T9168 14180-14312 Sentence denotes Taken together, these data suggest that RPS3 S209 phosphorylation is critical for NF-κB activity involving the canonical Ig κB site.
T9169 14313-14496 Sentence denotes We next used chromatin immunoprecipitation to determine whether S209 phosphorylation affects RPS3 and p65 recruitment to specific κB sites in intact chromatin during NF-κB activation.
T11937 15797-15841 Sentence denotes NleH1 inhibits RPS3 phosphorylation in vitro
T11938 15842-15944 Sentence denotes EHEC pathogens are important causative agents of both foodborne disease and pediatric renal failure31.
T11939 15945-16103 Sentence denotes EHEC utilize T3SS to inject effector proteins directly into intestinal epithelial cells32, a subset of which inhibit NF-κB-dependent innate responses9, 33-38.
T11940 16104-16253 Sentence denotes The E. coli O157:H7 EDL933 effector protein NleH1 binds to and attenuates RPS3 nuclear translocation, thus impairing RPS3-dependent NF-κB signaling9.
T11941 16254-16344 Sentence denotes We therefore hypothesized that NleH1 may function by inhibiting RPS3 S209 phosphorylation.
T11942 16345-16488 Sentence denotes As expected, transfecting increasing amounts of NleH1-HA plasmid blocked TNFα-induced NF-κB activation in a dose-dependent manner (Fig. 6a-b)9.
T11943 16489-16615 Sentence denotes Remarkably, NleH1 reduced both TNF-induced, as well as basal RPS3 phosphorylation to roughly 20% of vehicle control (Fig. 6c).
T11944 16616-16793 Sentence denotes Expressing NleH1 does not interfere with either TNF-induced IKK activation or IκBα degradation, consistent with the lack of NleH1 impact on p65 nuclear translocation9 (Fig. 6c).
T11945 16794-17038 Sentence denotes To determine if NleH1 inhibits RPS3 phosphorylation, we infected HeLa cells with E. coli O157:H7 strains possessing or lacking either nleH1 (ΔnleH1) or with a strain lacking a functional T3SS unable to inject NleH1 into mammalian cells (ΔescN).
T11946 17039-17166 Sentence denotes In uninfected cells, TNF-treatment stimulated a ∼7-fold increase in RPS3 S209 phosphorylation, peaking at 30 minutes (Fig. 6d).
T11947 17167-17292 Sentence denotes By contrast, RPS3 S209 phosphorylation was substantially impaired in cells infected with wild-type E. coli O157:H7 (Fig. 6d).
T11948 17293-17411 Sentence denotes However, TNF-induced RPS3 S209 phosphorylation was unimpaired in cells infected with either ΔnleH1 or ΔescN (Fig. 6d).
T11949 17412-17554 Sentence denotes We showed previously that wild-type, but not ΔnleH1 or ΔescN E. coli O157:H7 significantly attenuated TNF-induced RPS3 nuclear translocation9.
T11950 17555-17793 Sentence denotes The parallel between RPS3 phosphorylation and its nuclear translocation during E. coli infection provides evidence in the context of an NF-κB-dependent disease process that RPS3 S209 phosphorylation is important for nuclear translocation.
T11951 17794-17970 Sentence denotes Our discovery that NleH1 inhibits RPS3 S209 phosphorylation suggested that it should also blocks RPS3-dependent NF-κB target gene transcription (e.g. IL8, NFKBIA, and TNFAIP3).
T11952 17971-18162 Sentence denotes Indeed, these genes were only modestly upregulated in cells infected with wild-type E. coli O157:H7, but significantly induced in cells infected with either ΔnleH1 or ΔescN strains (Fig. 6e).
T11953 18163-18302 Sentence denotes In contrast, deleting nleH1 had no impact on the expression of RPS3-independent genes, including CD25 and TNFSF13B (Supplementary Fig. 12).
T11954 18303-18514 Sentence denotes Together these results demonstrate that NleH1 specifically inhibits the protective immune response by directly blocking RPS3 S209 phosphorylation and thereby impairing critical RPS3-dependent NF-κB target genes.
T13755 18516-18564 Sentence denotes NleH1 inhibits RPS3 S209 phosphorylation in vivo
T13756 18565-18748 Sentence denotes We previously utilized a gnotobiotic piglet infection model to determine that piglets infected with ΔnleH1 mutant died more rapidly than those infected with wild-type E. coli O157:H7.
T13757 18749-18914 Sentence denotes Piglets infected with ΔnleH1 displayed clinical disease consistent with a robust inflammatory response, but with reduced bacterial colonization and little diarrhea9.
T13758 18915-19122 Sentence denotes While seemingly paradoxical, based on our cell culture data (Fig. 6d), we hypothesized that NleH1 blocked RPS3 S209 phosphorylation in vivo, thereby preventing RPS3 nuclear translocation in infected piglets.
T13759 19123-19237 Sentence denotes We isolated piglet colons at necropsy, and subjected them to immunohistochemistry using our phospho-RPS3 antibody.
T13760 19238-19481 Sentence denotes Consistent with in vitro data, piglets infected with wild-type E. coli O157:H7 exhibited diffuse and low intensity phospho-RPS3 staining, whereas in piglets infected with ΔnleH1 mutant, phospho-RPS3 expression was florid and intense (Fig. 6f).
T13761 19482-19645 Sentence denotes These data demonstrate that NleH1 inhibits RPS3 S209 phosphorylation both in vitro and in vivo, which might benefit the bacterium in colonization and transmission.
T14904 19647-19692 Sentence denotes NleH1 steers the IKKβ substrate specificities
T14905 19693-19789 Sentence denotes NleH1 is an autophosphorylated serine-threonine kinase, which depends on the lysine 159 (K159)9.
T14906 19790-20091 Sentence denotes To explore the mechanism by which NleH1 inhibits RPS3 S209 phosphorylation, we first performed an in vitro kinase assay with purified wild-type His-NleH1 protein and a mutant His-NleH1 (K159A) protein, confirming that NleH1 is autophosphorylated and the K159A is an NleH1 kinase-dead mutant (Fig. 7a).
T14907 20092-20274 Sentence denotes To examine whether the kinase activity is required for NleH1 to inhibit IKKβ phosphorlyation of RPS3 on S209, we ectopically expressing either wild-type or K159A NleH1 in 293T cells.
T14908 20275-20414 Sentence denotes Wild-type NleH1 expression significantly reduced TNF-induced RPS3 S209 phosphorylation, whereas the K159A mutant failed to do so (Fig. 7b).
T14909 20415-20505 Sentence denotes Thus NleH1 kinase activity is required to protect RPS3 from IKKβ-mediated phosphorylation.
T14910 20506-20781 Sentence denotes Citrobacter rodentium is a mouse pathogen that shares pathogenic strategies with E. coli 39, most notably for our investigation, C. rodentium NleH inhibited RPS3 nuclear translocation and RPS3-dependent NF-κB luciferase activity to an extent equivalent to E. coli NleH1 (ref.
T14911 20782-20785 Sentence denotes 9).
T14912 20786-20882 Sentence denotes We assayed RPS3 S209 phosphorylation in HeLa cells infected with different C. rodentium strains.
T14913 20883-20989 Sentence denotes In uninfected cells, TNF-treatment stimulated a ∼3.5-fold increase in RPS3 S209 phosphorylation (Fig. 7c).
T14914 20990-21103 Sentence denotes Such augmentation of RPS3 phosphorylation was reduced by about 60% by wild-type C. rodentium infection (Fig. 7c).
T14915 21104-21229 Sentence denotes However, RPS3 phosphorylation was enhanced when cells were infected with a C. rodentium strain lacking NleH (Fig. 7c, ΔnleH).
T14916 21230-21396 Sentence denotes We further examined the role of NleH1 kinase activity using the C. rodentium ΔnleH strain as a background on which to express either wild-type or K159A E. coli NleH1.
T14917 21397-21582 Sentence denotes Complementing ΔnleH mutant with wild-type NleH1 almost abolished TNF-induced RPS3 S209 phosphorylation whereas complementing with K159A failed to inhibit RPS3 phosphorylation (Fig. 7c).
T14918 21583-21697 Sentence denotes Collectively, these results demonstrate that NleH1 kinase activity is required to block RPS3 S209 phosphorylation.
T14919 21698-21896 Sentence denotes We next examined whether the inhibitory activity of NleH1 is sufficiently robust to impair the strong nuclear translocation of RPS3 trigged by the constitutively-active IKKβ (IKKβ [SSEE]) (Fig. 2d).
T14920 21897-22067 Sentence denotes We found that ectopically expressing either wild-type or SSEE IKKβ proteins, triggered more RPS3 nuclear translocation than the kinase-dead IKKβ (SSAA) protein (Fig. 7d).
T14921 22068-22181 Sentence denotes RPS3 nuclear accumulation was substantially retarded by infecting cells with wild-type E. coli O157:H7 (Fig. 7d).
T14922 22182-22349 Sentence denotes In contrast, infecting with either ΔnleH1 or ΔescN strains only slightly impaired RPS3 nuclear translocation in either IKKβ- or IKKβ (SSEE)-expressing cells (Fig. 7d).
T14923 22350-22501 Sentence denotes As expected, E. coli infections did not affect the RPS3 nuclear translocation in IKKβ (SSAA)-expressing cells, where NF-κB signaling was low (Fig. 7d).
T14924 22502-22647 Sentence denotes Thus, during infection NleH1 is sufficiently potent to inhibit RPS3 nuclear translocation even in cells expressing constitutively-activated IKKβ.
T14925 22648-22764 Sentence denotes We examined whether NleH1 could directly phosphorylate IKKβ thus inhibiting IKKβ-mediated RPS3 S209 phosphorylation.
T14926 22765-22974 Sentence denotes We performed in vitro kinase assays using immunoprecipitated Flag-IKKβ (K44A) as substrate and recombinant His-NleH1 as kinase, so that IKKβ autophosphorylation would not obscure NleH1-induced phosphorylation.
T14927 22975-23102 Sentence denotes However, we did not observe any detectable 32P incorporation in IKKβ (Supplementary Fig. 13), thus ruling out this possibility.
T14928 23103-23189 Sentence denotes We then tested the hypothesis that NleH1 could alter the IKKβ substrate specificities.
T14929 23190-23282 Sentence denotes To this end, we performed in vitro kinase assays using both CK2 and IKK substrates for IKKβ.
T14930 23283-23451 Sentence denotes As expected, IKKβ phosphorylated RPS3 (Fig. 7e, lane 7) and GST-IκBα (1-54) protein (Fig. 7e, lane 9), demonstrating it harbors either CK2 or IKK substrate specificity.
T14931 23452-23652 Sentence denotes Preincubation of IKKβ with NleH1 reduced IKKβ-mediated RPS3 phosphorylation, i.e. the CK2 kinase specificity, but not IKKβ-mediated GST-IκBα phosphorylation, i.e. the IKK kinase specificity (Fig. 7e).
T14932 23653-23769 Sentence denotes Control experiments revealed no NleH1-mediated phosphorylation or autophosphorylation of RPS3 or GST-IκBα (Fig. 7e).
T14933 23770-23992 Sentence denotes Taken together, NleH1 blocks the CK2 substrate specificity of IKKβ thus inhibiting the IKKβ-mediated RPS3 S209 phosphorylation thus representing a novel strategy by E. coli O157:H7 to alter the host innate immune response.
T20201 28191-28209 Sentence denotes Cells and Reagents
T20202 28210-28401 Sentence denotes Jurkat E6.1, HEK293T and HeLa cells were cultured in RPMI 1640 and DMEM supplemented with 10% fetal calf serum, 2 mM glutamine, and 100 U/ml each of penicillin and streptomycin, respectively.
T20203 28402-29130 Sentence denotes IκBα (C-21, sc-371), p65 (C-20, sc-372), and phospho-threonine (H-2, sc-5267) antibodies were from Santa Cruz Biotechnology; β-actin (AC-15, A5441), Flag (M2, F3165), HA (HA-7, H3663), importin-α (IM-75, I1784), and importin-β (31H4, I2534) antibodies were from Sigma; PARP (C2-10, 556362), IKKα (B78-1, 556532), and IKKβ (24, 611254) antibodies were from BD Pharmingen; CK2α (31, 611610) and Hsp90 (68, 610418) antibodies were from BD Transduction Laboratories; phospho-IκBα (5A5, 9246S) and phospho-IKKα/β (16A6, 2697S) antibodies were from Cell Signaling Technology; phospho-serine (AB1603) and phospho-tyrosine (4G10, 05-777) antibodies were from Millipore. The rabbit polyclonal RPS3 antiserum was as described previously6.
T20204 29131-29296 Sentence denotes The rabbit polyclonal antibody specific for S209 phosphorylated RPS3 was generated and affinity purified by Primm Biotech using the peptide NH2-CKPLPDHV(Sp)IVE-COOH.
T20515 29298-29316 Sentence denotes Plasmid Constructs
T20516 29317-29476 Sentence denotes The Flag-IKKβ (SSEE), Flag-IKKβ (SSAA), and HA-IκBα (SSAA) constructs were provided by C. Wu (NCI, Bethesda) and U. Siebenlist (NIAID, Bethesda), respectively.
T20517 29477-29553 Sentence denotes The HA-IκBα and IKKβ (K44A)-Flag plasmids were purchased from Addgene44, 45.
T20518 29554-29643 Sentence denotes The Flag-RPS3, GST-RPS3, HA-RPS3, VN-HA, NleH1-HA plasmids were described previously6, 9.
T20519 29644-29877 Sentence denotes The point mutants of RPS3 were generated by site-directed mutagenesis using the Quick Change Kit (Stratagene) with primers forward 5′-CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3′ and reverse 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′ for S209A.
T20520 29878-29922 Sentence denotes All mutants were verified by DNA sequencing.
T20843 29924-29944 Sentence denotes 32P in vivo Labeling
T20844 29945-30067 Sentence denotes HEK 293T cells were labeled with 2 mCi/ml 32P-orthophosphate (Perkin Elmer) in phosphate-free medium (Invitrogen) for 2 h.
T20845 30068-30165 Sentence denotes Cells were then left untreated or treated with TNF (50 ng/ml, R&D Systems) for indicated periods.
T20846 30166-30246 Sentence denotes Cell lysates were prepared and used for immunoprecipitations with RPS3 antibody.
T20989 30248-30269 Sentence denotes In Vitro Kinase Assay
T20990 30270-30380 Sentence denotes Kinase-active recombinant IKKβ and IKKα proteins were purchased from Active Motif and Millipore, respectively.
T20991 30381-30521 Sentence denotes Bacterially purified glutathione S-transferase (GST), GST-IκBα (1-54), wild type, mutant GST-RPS3, or RPS3 proteins were used as substrates.
T20992 30522-30588 Sentence denotes The in vitro kinase assay was performed as previously described29.
T20993 30589-30907 Sentence denotes Briefly, enzyme (100 ng) and substrate (2 μg) were co-incubated in IKK reaction buffer (25 mM Tris–HCl [pH 8.0], 50 mM KCl, 10 mM MgCl2, 1 mM DTT, 1 mM Na3VO4, 1 mM ATP) or NleH1 reaction buffer (50 mM Tris-HCl [pH 7.6], 5 mM MgCl2, 1 mM DTT, 1 mM ATP) with 0.5 μCi 32P-γ-ATP (GE Healthcare) added at 37 °C for 30 min.
T20994 30908-30982 Sentence denotes The reactions were resolved by SDS–PAGE and visualized by autoradiography.
T21363 30984-31001 Sentence denotes LC-MS/MS Analysis
T21364 31002-31155 Sentence denotes GST or GST-RPS3 was incubated with recombinant IKKβ protein as described above in an in vitro kinase assay reaction conducted without 32P-γ-ATP labeling.
T21365 31156-31261 Sentence denotes The reaction was separated by SDS-PAGE, and the protein gel was stained with Colloidal Blue (Invitrogen).
T21366 31262-31428 Sentence denotes The corresponding protein fragments were excised and subjected to trypsin digestion and LC-MS/MS at the Yale Cancer Center Mass Spectrometry Resource (New Haven, CT).
T21706 31774-31799 Sentence denotes Subcellular Fractionation
T21707 31800-31896 Sentence denotes Subcellular fractionation was performed by differential centrifugation as previously described6.
T21708 31897-32103 Sentence denotes Briefly, cells were resuspended in ice-cold Buffer A (10 mM HEPES pH 7.9, 10 mM KCl, 1.5 mM MgCl2, 0.1 mM EDTA, 0.5 mM DTT, 0.4 % NP-40, 0.5 mM PMSF, complete protease inhibitor cocktail) at 4 °C for 5 min.
T21709 32104-32212 Sentence denotes Lysates were centrifuged at 4 °C, 500 × g for 3 min, and supernatants were collected as cytosolic fractions.
T21710 32213-32404 Sentence denotes Pellets were incubated in Buffer C (20 mM HEPES pH7.9, 420 mM NaCl, 1.5 mM MgCl2, 25% glycerol, 0.5 mM PMSF, 0.2 mM EDTA, 0.5 mM DTT, complete protease inhibitor cocktail) at 4 °C for 10 min.
T21711 32405-32508 Sentence denotes Supernatants were collected as nuclear fractions following a centrifuge at 4 °C, 13,800 × g for 10 min.
T22039 32802-32884 Sentence denotes Cells were cultured for 1–2 days and then stimulated in triplicate before harvest.
T22040 32885-32947 Sentence denotes Lysates were analyzed using the Dual-Luciferase Kit (Promega).
T22214 32949-32985 Sentence denotes Chromatin Immunoprecipitation (ChIP)
T22215 32986-33037 Sentence denotes ChIP assays was performed as previously described6.
T22216 33038-33167 Sentence denotes The primers used to amplify the promoter region adjacent to the κB sites of IL8 and NFKBIA, as well as ACTB have been described6.
T22324 33169-33198 Sentence denotes Immunofluorescence Microscopy
T22325 33199-33258 Sentence denotes Confocal microscopy was performed as previously described6.
T22326 33259-33356 Sentence denotes Briefly, cells were fixed with 4 % paraformaldehyde in PBS and then Cellspin mounted onto slides.
T22327 33357-33739 Sentence denotes The fixed cells were then permeabilized with 0.05 % Triton X-100 in PBS and stained with FITC-conjugated rabbit anti-RPS3 antibodies (Primm Biotech), or AlexaFluor 594-conjugated rat anti-Flag antibodies (BD) for 40 min together with 1 μg/ml of Hoechst 33342 (Sigma) for 5 min at 25 °C. The slides were then rinsed with PBS three times and cover mounted for fluorescence microscopy.
T22542 33741-33775 Sentence denotes Immunoprecipitation and immunoblot
T22543 33776-34105 Sentence denotes The cells were harvested and lysed on ice by 0.4 ml of the modified RIPA buffer (50 mM Tris-HCl [pH 7.4], 1% NP-40, 0.25% Na-deoxycholate, 150 mM NaCl, 1 mM EDTA, 1 mM PMSF, 1 mM Na3VO4, 1 mM NaF) supplemented with 1 × protease inhibitor cocktail (Roche) and 1 × phosphatase inhibitor cocktail set I (EMD Biosciences) for 30 min.
T22544 34106-34197 Sentence denotes The lysates were centrifuged at 10,000 × g at 4 °C for 10 min to remove insoluble material.
T22545 34198-34551 Sentence denotes After normalizing protein concentrations, lysates were subjected to immunoprecipitation by adding 10 mg/ml appropriate antibody plus 30 ml of protein G-agarose (Roche), and rotated for at least 2 h at 4°C. The precipitates were washed at least five times with cold lysis buffer followed by separation by SDS-PAGE under reduced and denaturing conditions.
T22546 34552-34697 Sentence denotes Nitrocellulose membranes were blocked in 5 % nonfat milk in 0.1 % PBS-Tween 20 (PBS-T), probed with specific antibodies as described previously6.
T22547 34698-34868 Sentence denotes For immunoblotting of phosphorylated proteins, gels were transferred to methanol-treated polyvinylidene chloride membranes, retreated with methanol, and dried for 30 min.
T22548 34869-35026 Sentence denotes Blots were blocked in 5 % bovine serum albumin in 0.1 % Tris buffered saline-Tween 20 (TBS-T), and probed with specific antibodies as described previously46.
T22549 35027-35129 Sentence denotes Bands were imaged by the Super Signaling system (Pierce) according to the manufacturer's instructions.
T23103 35131-35136 Sentence denotes ELISA
T23104 35137-35338 Sentence denotes The amount of IL-8 present in supernatants collected from Jurkat cell culture was measured using a Human Interleukin-8 ELISA Ready-SET-Go kit (eBioscience) according to the manufacturer's instructions.
T23193 35340-35355 Sentence denotes Cell Infections
T23194 35356-35451 Sentence denotes HeLa cells were infected with E. coli O157:H7 or C. rodentium strains as described previously9.
T23239 35453-35473 Sentence denotes Immunohistochemistry
T23240 35474-35562 Sentence denotes Gnotobiotic piglets were infected with E. coli O157:H7 strains as described previously9.
T23241 35563-35638 Sentence denotes Spiral colon specimens were collected at necropsy and embedded in paraffin.
T23242 35639-35752 Sentence denotes Paraffin sectioning and immunohistochemical staining using phospho-RPS3 antibody were performed by Histoserv Inc.
T94 0-118 Sentence denotes IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during Escherichia coli O157:H7 infection
T95 130-275 Sentence denotes NF-κB is a major gene regulator in immune responses and ribosomal protein S3 (RPS3) is an NF-κB subunit that directs specific gene transcription.
T96 276-343 Sentence denotes However, it is unknown how RPS3 nuclear translocation is regulated.
T97 344-482 Sentence denotes Here we report that IKKβ phosphorylation of serine 209 (S209) was crucial for RPS3 nuclear localization in response to activating stimuli.
T98 483-760 Sentence denotes Moreover, the foodborne pathogen Escherichia coli O157:H7 virulence protein NleH1 specifically inhibited RPS3 S209 phosphorylation and blocked RPS3 function, thereby promoting bacterial colonization and diarrhea but decreasing mortality in a gnotobiotic piglet infection model.
T99 761-937 Sentence denotes Thus, the IKKβ-dependent modification of a specific amino acid in RPS3 promotes specific NF-κB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.
T9170 14497-14681 Sentence denotes In RPS3 knockdown cells, PMA+I stimulated the recruitment of ectopically expressed, Flag-tagged wild-type, but not S209A RPS3 to the κB sites of the NFKBIA and IL8 promoters (Fig. 5e).
T9171 14682-14808 Sentence denotes While expressing RPS3 S209A had no impact on p65 nuclear translocation, it substantially attenuated p65 recruitment (Fig. 5e).
T9172 14809-15003 Sentence denotes Additional experiments revealed that p65 attraction to RPS3-independent NF-κB target gene promoters such as CD25 was increased (Supplementary Fig. 9), consistent with our previous observations6.
T9173 15004-15151 Sentence denotes There was no significant Flag-RPS3 or p65 recruitment to ACTB promoter lacking κB sites (Fig. 5e), suggesting the recruitment was κB site-specific.
T9174 15152-15261 Sentence denotes Thus, the recruitment of RPS3 as well as the contingent recruitment of p65 to key promoters depended on S209.
T9175 15262-15528 Sentence denotes Interleukin 8 (IL-8) secretion induced by either T cell receptor (TCR) agonist stimulation or PMA+I was decreased as a consequence of reduced RPS3/p65 recruitment to the IL8 κB sites in the presence of S209A mutant compared to wild-type RPS3 (Supplementary Fig. 10).
T9176 15529-15661 Sentence denotes However, cell surface CD25 expression was comparable between the wild-type and S209A RPS3 transfected cells (Supplementary Fig. 11).
T9177 15662-15795 Sentence denotes Therefore, RPS3 S209 phosphorylation by IKKβ is apparently required for RPS3 in directing NF-κB to a specific subset of target genes.
T18122 24005-24114 Sentence denotes RPS3 was previously demonstrated to function as an integral subunit conferring NF-κB regulatory specificity6.
T18123 24115-24252 Sentence denotes Here we sought to elucidate how NF-κB activation signaling triggers RPS3 to translocate and participate in NF-κB function in the nucleus.
T18124 24253-24448 Sentence denotes We demonstrate that IKKβ-mediated RPS3 S209 phosphorylation represents a critical determinant in governing its nuclear import thus unveiling a novel mechanism behind NF-κB regulatory specificity.
T18125 24449-24573 Sentence denotes IKKβ is the major kinase that phosphorylates IκBs in the classical NF-κB pathway, leading to their subsequent degradation40.
T18126 24574-24681 Sentence denotes Strikingly, RPS3 possesses not any consensus IKK motif; instead, S209 is centered in a consensus CK2 motif.
T18127 24682-24855 Sentence denotes The recent observation that human IKKβ displayed CK2-like phosphorylation specificity29 coincides with our evidence that recombinant IKKβ, but not IKKα, phosphorylated RPS3.
T18128 24856-25006 Sentence denotes We found this phosphorylation is a critical modulation for RPS3 nuclear translocation (via importin-α) and engagement in specific NF-κB transcription.
T18129 25007-25299 Sentence denotes CK2 was previously shown to phosphorylate p65 and to bind to and phosphorylate IKKβ41-43, however, we ruled out the possibility that the IKKβ-bound CK2 could account for the observed RPS3 phosphorylation because no CK2 was detected in the IKKβ preparations used for the in vitro kinase assay.
T18130 25300-25486 Sentence denotes Because RPS3 only harbors the CK2 motif and not a traditional IKK motif, this RPS3 regulatory function could explain why IKK harbors the alternative substrate phosphorylation capability.
T18131 25487-25686 Sentence denotes More importantly, our study has elucidated how RPS3 is biochemically integrated into NF-κB activation signaling in a manner that is pivotal for the pathogenesis of foodborne pathogen E. coli O157:H7.
T18132 25687-25807 Sentence denotes IKKβ-mediated RPS3 S209 phosphorylation is a critical target modulated by this pathogen to subvert host NF-κB signaling.
T18133 25808-25973 Sentence denotes The bacterial effector NleH1 specifically binds to RPS3 once injected into host cells and profoundly suppresses NF-κB and its attendant protective immune responses9.
T18134 25974-26157 Sentence denotes Our data now show that NleH1 selectively inhibits RPS3 phosphorylation, thus retarding its nuclear translocation and subsequent NF-κB function, without altering other NF-κB signaling.
T18135 26158-26294 Sentence denotes Although NleH1 did not directly phosphorylate IKKβ, its kinase activity was required to inhibit IKKβ-mediated RPS3 S209 phosphorylation.
T18136 26295-26524 Sentence denotes Many bacteria pathogens have products that target key kinases to inactivate them in host cells, whereas E. coli O157:H7 employed NleH1 to steer the substrate specificity of IKKβ thus specifically fine-tuning host NF-κB signaling.
T18137 26525-26637 Sentence denotes This could represent a novel strategy to fine-tune host NF-κB signaling that could be shared by other pathogens.
T18138 26638-26738 Sentence denotes These data provide new insights into the poorly understood action mechanism for most T3SS effectors.
T18139 26739-26923 Sentence denotes NleH1 attenuates the transcription of RPS3-dependent, but not all, NF-κB target genes, in particular those genes associated with acute proinflammatory responses, including IL8 and TNF.
T18140 26924-27159 Sentence denotes In contrast, NleH1 does not block NF-κB p65 nuclear translocation, which suggests that certain p65-dependent but RPS3-independent NF-κB target genes might thus be beneficial for E. coli O157:H7 to replicate and disseminate in the host.
T18141 27160-27347 Sentence denotes By selectively inhibiting RPS3 and its attendant NF-κB function with NleH1, the pathogen achieves the ability to increase colonization and diarrhea yet limiting the mortality of the host.
T18142 27348-27605 Sentence denotes This seemingly paradoxical combination of effects make sense when one considers that increased bacterial load and diarrhea together with survival of the infected host would promote the spreading of the bacteria among a population of susceptible individuals.
T18143 27606-27744 Sentence denotes Such complex and paradoxical pathological effects that influence the spread of disease are often poorly understood at the molecular level.
T18144 27745-27981 Sentence denotes Our data elucidate how alterations in selective NF-κB function, achieved by impeding RPS3, but not altering p65 nuclear translocation, can influence specific cytokines that affect bacterial colonization, diarrhea diseases and mortality.
T18145 27982-28180 Sentence denotes It may be fruitful in attempting to understand other infectious and autoimmune diseases involving NF-κB to consider selective effects of subunits such as RPS3 in addition to global NF-κB inhibition.
T21548 31430-31451 Sentence denotes RNAi and Transfection
T21549 31452-31661 Sentence denotes The siRNA (sense-strand sequence) IKKα, 5′-AUGACAGAGAAUGAUCAUGUUCUGC -3′; IKKβ, 5′-GCAGCAAGGAGAACAGAGGUUAAUA -3′; IκBα, 5′-GAGCUCCGAGACUUUCGAGGAAAUA -3′; RPS3-3′ UTR, 5′-GGAUGUUGCUCUCUAAAGACC -3′ (Invitrogen).
T21550 31662-31772 Sentence denotes Transient transfection of siRNA and DNA constructs into Jurkat cells and 293T cells was described previously6.
T22036 32510-32541 Sentence denotes Luciferase Reporter Gene Assays
T22037 32542-32614 Sentence denotes Luciferase reporter gene assays were performed as previously described6.
T22038 32615-32801 Sentence denotes Briefly, cells were cotransfected at a ratio of 10:1 with various promoter-driven firefly luciferase constructs to the Renilla luciferase pTKRL plasmid, together with indicated plasmids.
T1 0-118 Sentence denotes IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during Escherichia coli O157:H7 infection
T2 121-129 Sentence denotes Abstract
T3 130-275 Sentence denotes NF-κB is a major gene regulator in immune responses and ribosomal protein S3 (RPS3) is an NF-κB subunit that directs specific gene transcription.
T4 276-343 Sentence denotes However, it is unknown how RPS3 nuclear translocation is regulated.
T5 344-482 Sentence denotes Here we report that IKKβ phosphorylation of serine 209 (S209) was crucial for RPS3 nuclear localization in response to activating stimuli.
T6 483-760 Sentence denotes Moreover, the foodborne pathogen Escherichia coli O157:H7 virulence protein NleH1 specifically inhibited RPS3 S209 phosphorylation and blocked RPS3 function, thereby promoting bacterial colonization and diarrhea but decreasing mortality in a gnotobiotic piglet infection model.
T7 761-937 Sentence denotes Thus, the IKKβ-dependent modification of a specific amino acid in RPS3 promotes specific NF-κB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.
T8 939-1134 Sentence denotes Nuclear Factor-kappa B (NF-κB) regulates crucial cellular functions and diverse stimuli activate this pleiotropic transcription factor, which in turn regulates a vast array of genetic targets1-3.
T9 1135-1247 Sentence denotes The best-known mammalian NF-κB subunits are Rel proteins, including RelA (p65), RelB, c-Rel, p50, and p52 (refs.
T10 1248-1254 Sentence denotes 4, 5).
T11 1255-1382 Sentence denotes However, we recently demonstrated that ribosomal protein S3 (RPS3) is a key non-Rel subunit of certain native NF-κB complexes6.
T12 1383-1563 Sentence denotes RPS3 is defined as a “specifier” subunit of NF-κB, because it facilitates high affinity DNA binding thus determining the regulatory specificity of NF-κB for selected target genes7.
T13 1564-1822 Sentence denotes RPS3 regulation of NF-κB governs key physiological processes, including immunoglobulin κ light chain gene expression and receptor editing in B cells6, 8, cytokine production in T cells6, and in host defense against enterohemorrhagic Escherichia coli (EHEC)9.
T14 1823-2044 Sentence denotes In particular, the E. coli O157:H7 type III secretion system (T3SS) effector protein NleH1 selectively blocks NF-κB target gene transcription by attenuating RPS3 nuclear translocation, without affecting p65 localization9.
T15 2045-2141 Sentence denotes Nonetheless, how specific NF-κB activating signals induce RPS3 nuclear translocation is unknown.
T16 2142-2211 Sentence denotes Extra-ribosomal functions have been ascribed to ribosomal proteins10.
T17 2212-2337 Sentence denotes Besides binding RNA within the 40S ribosomal subunit, RPS3 participates in transcription6, DNA repair11, 12, and apoptosis13.
T18 2338-2404 Sentence denotes Whether or not RPS3 is phosphorylated had been controversial14-18.
T19 2405-2593 Sentence denotes Since kinase cascades play a critical role in NF-κB regulation, we tested whether RPS3 is phosphorylated in the context of NF-κB activation and sought to identify the responsible kinase19.
T20 2594-2704 Sentence denotes Additionally, we aimed to define a regulatory role for the C-terminal tail of RPS3 whose function was unknown.
T21 2705-2809 Sentence denotes Here we show that the Inhibitor of κB (IκB) kinase beta (IKKβ) phosphorylated RPS3 at serine 209 (S209).
T22 2810-2954 Sentence denotes RPS3 S209 phosphorylation enhanced its association with importin-α, mediating RPS3 entry into the karyopherin pathway for nuclear translocation.
T23 2955-3115 Sentence denotes Furthermore, the E. coli NleH1 effector specifically inhibited RPS3 S209 revealing how E. coli O157:H7 inhibits this important innate immune response mechanism.
T24 3117-3124 Sentence denotes Results
T25 3126-3178 Sentence denotes RPS3 phosphorylation in response to NF-κB activation
T26 3179-3338 Sentence denotes To test whether RPS3 is phosphorylated during NF-κB activation, we performed 32P-labeling experiments in tumor necrosis factor (TNF)-stimulated HEK 293T cells.
T27 3339-3520 Sentence denotes While RPS3 was scarcely phosphorylated in unstimulated cells, we observed a marked increase in 32P-incorporation after TNF stimulation despite no increase in RPS3 protein (Fig. 1a).
T28 3521-3712 Sentence denotes To determine which RPS3 residues were phosphorylated, we immunoprecipitated RPS3 from either resting or stimulated cells and performed immunoblotting with phosphorylation-specific antibodies.
T29 3713-3966 Sentence denotes Both TNF and phorbol myristate acetate/ionomycin (PMA+I) stimulated rapid phosphorylation and degradaion of IκBα within 5 min which was accompanied by RPS3 phosphorylation on serine residues (Fig. 1b and data not shown), similar to the in vivo labeling.
T30 3967-4042 Sentence denotes We did not detect tyrosine- or threonine-phosphorylation of RPS3 (Fig. 1b).
T31 4044-4069 Sentence denotes RPS3 and IKKβ interaction
T32 4070-4310 Sentence denotes The activation of the inhibitor of κB kinase (IKK), consisting of a regulatory subunit IKKγ and two catalytic subunits, IKKα and IKKβ, is critical for the phosphorylation and dispatch of the inhibitory IκBs and the liberation of NF-κB20-22.
T33 4311-4488 Sentence denotes Given that RPS3 can be found in the cytoplasmic p65-p50-IκBα inhibitory complex in resting cells6, we hypothesized that activated IKKβ might also bind to and phosphorylate RPS3.
T34 4489-4567 Sentence denotes First, we found that ectopically expressed IKKβ and RPS3 interacted (Fig. 1c).
T35 4568-4774 Sentence denotes We next examined resting Jurkat cells and detected a modest endogenous IKKβ-RPS3 interaction (Fig. 1d), potentially accounting for the basal NF-κB transcription required for cell proliferation and survival.
T36 4775-4939 Sentence denotes RPS3-IKKβ association was clearly augmented upon TNF stimulation, peaking at 10 min. (Fig. 1d), following similar kinetics to RPS3 serine phosphorylation (Fig. 1b).
T37 4940-5021 Sentence denotes By contrast, there was no detectable interaction between RPS3 and IKKα (Fig. 1d).
T38 5023-5070 Sentence denotes IKKβ is required for RPS3 nuclear translocation
T39 5071-5319 Sentence denotes To examine whether the RPS3-IKKβ interaction is required for RPS3 nuclear translocation, we knocked down IKKα or IKKβ expression with siRNAs (Supplementary Fig. 1) and then observed stimulation-induced RPS3 nuclear migration by confocal microscopy.
T40 5320-5455 Sentence denotes Both TNF and PMA+I triggered RPS3 nuclear translocation in Jurkat cells transfected with a scrambled nonspecific (NS) siRNA (Fig. 2a)6.
T41 5456-5540 Sentence denotes RPS3 nuclear translocation was only slightly, if at all, impaired by IKKα-silencing.
T42 5541-5650 Sentence denotes Conversely, knockdown of IKKβ attenuated 60-70% of RPS3 nuclear accumulation following stimulation (Fig. 2a).
T43 5651-5815 Sentence denotes Immunoblotting of nuclear fractions confirmed that full expression of IKKβ, but not IKKα, was necessary for activation-induced RPS3 nuclear translocation (Fig. 2b).
T44 5816-5924 Sentence denotes Control immunoblots revealed that p65 nuclear translocation was blocked under the same conditions (Fig. 2b).
T45 5925-6087 Sentence denotes We next examined the nuclear translocation of RPS3 in cells ectopically expressing either kinase-dead (SSAA) or constitutively-active (SSEE) mutant IKKβ proteins.
T46 6088-6209 Sentence denotes As expected, the SSEE, but not SSAA, mutant of IKKβ induced NF-κB-dependent luciferase reporter activity (Fig. 2c, left).
T47 6210-6402 Sentence denotes Whereas RPS3 remained cytosolic in IKKβ (SSAA)-expressing cells (Fig. 2c, right), a substantial proportion of RPS3 translocated to the nucleus in cells expressing IKKβ (SSEE) (Fig. 2c, right).
T48 6403-6586 Sentence denotes The percentage of cells containing detectable nuclear RPS3 increased 5-fold in IKKβ (SSEE)-expressing cells, but not in IKKβ (SSAA)-expressing ones (Fig. 2d and Supplementary Fig. 2).
T49 6587-6706 Sentence denotes Thus, IKKβ activity is necessary and sufficient for RPS3 nuclear translocation in response to NF-κB activating stimuli.
T50 6708-6755 Sentence denotes IκBα degradation and RPS3 nuclear translocation
T51 6756-6824 Sentence denotes Importin-α regulates the nuclear import of NF-κB Rel subunits23, 24.
T52 6825-6977 Sentence denotes RPS3 harbors a nuclear localization signal (NLS) sequence and its nuclear translocation occurs in parallel to, but independently of, p65 translocation6.
T53 6978-7046 Sentence denotes We envisioned that RPS3 could also utilize the importin-α/β pathway.
T54 7047-7177 Sentence denotes Consistent with this notion, RPS3 association with importin-α, but not importin-β, was enhanced in TNF–stimulated cells (Fig. 3a).
T55 7178-7299 Sentence denotes Therefore, we examined whether RPS3 binding to importin-α is essential for nuclear translocation during NF-κB activation.
T56 7300-7515 Sentence denotes Since IκBα degradation is a prerequisite to unmask the NLS of p65, and both RPS3 and IκBα bind to p65 in the cytoplasmic inhibitory complex, we tested whether IκBα degradation is required for the liberation of RPS3.
T57 7516-7695 Sentence denotes We measured the association of RPS3 with importin-α in 293T cells overexpressing wild-type IκBα or an IκBα mutant (SSAA) resistant to IKKβ-induced phosphorylation and degradation.
T58 7696-7851 Sentence denotes In cells transfected with wild-type IκBα, TNF stimulation augmented the interaction of RPS3 and importin-α to a similar degree as in non-transfected cells.
T59 7852-7977 Sentence denotes By contrast, we observed that the RPS3-importin-α association was abolished by the presence of non-degradable IκBα (Fig. 3b).
T60 7978-8166 Sentence denotes To examine whether IκBα is the only cytoplasmic barrier precluding RPS3 nuclear translocation, we measured both RPS3-importin-α association and nuclear RPS3 after reducing IκBα expression.
T61 8167-8282 Sentence denotes Compared with nonspecific siRNA, siRNA targeting of IκBα completely depleted IκBα in Jurkat cells (Fig. 3c, input).
T62 8283-8410 Sentence denotes Nevertheless, the RPS3-importin-α association was not augmented (Fig. 3c), nor was significant nuclear RPS3 detected (Fig. 3d).
T63 8411-8723 Sentence denotes Moreover, cells treated with sodium pervanadate (Pv) to induce IκBα degradation through an IKK-independent mechanism25-27 did not show increased association between RPS3 and importin-α (Fig. 3e and Supplementary Fig. 3b) or nuclear accumulation of RPS3, despite complete IκBα degradation (Supplementary Fig. 3c).
T64 8724-8892 Sentence denotes We further examined whether a subsequent NF-κB activation signal independently promotes the importin-α association and nuclear transport of RPS3 after IκBα degradation.
T65 8893-9042 Sentence denotes We found that TNF stimulation following Pv treatment was required for the RPS3-importin-α association, comparable to TNF stimulation alone (Fig. 3e).
T66 9043-9200 Sentence denotes Thus, IκBα phosphorylation and degradation itself is required but not sufficient to cause RPS3 association with importin-α followed by nuclear translocation.
T67 9201-9285 Sentence denotes Rather, an additional signal, potentially IKKβ phosphorylation of RPS3, is required.
T68 9287-9325 Sentence denotes IKKβ phosphorylates RPS3 at serine 209
T69 9326-9520 Sentence denotes Although originally defined as the kinase that phosphorylates IκB19, IKKβ also phosphorylates unrelated substrates including 14-3-3β and Bcl10, which lack the IKK consensus motif (DpSGYXpS/T)28.
T70 9521-9591 Sentence denotes We therefore hypothesized that IKKβ could directly phosphorylate RPS3.
T71 9592-9910 Sentence denotes By in vitro kinase assays using recombinant IKK and RPS3 proteins, we observed strong incorporation of 32P in autophosphorylatd IKKα and IKKβ (Fig. 4a, lanes 2-7) as well as phosporylated GST-IκBα (1-54) (Supplementary Fig. 4), but not the GST protein alone (Fig. 4a, lanes 3 and 6), when either IKKα or IKKβ was used.
T72 9911-10028 Sentence denotes We discovered that GST-RPS3 could be phosphorylated by IKKβ, but not IKKα, in vitro (Fig. 4a, compare lanes 4 and 7).
T73 10029-10200 Sentence denotes To identify the RPS3 amino acid residue(s) phosphorylated by IKKβ, we performed liquid chromatography-tandem mass spectrometry analyses using in vitro phosphorylated RPS3.
T74 10201-10295 Sentence denotes The results indicated that IKKβ phosphorylated S209, located in the RPS3 C-terminus (Fig. 4b).
T75 10296-10558 Sentence denotes RPS3 amino acid sequence alignment revealed that S209 is conserved in many species throughout phylogeny with the exception of Caenorhabditis elegans and Schizosaccharomyces pombe, two organisms that do not possess the NF-κB signal pathway (Supplementary Fig. 5).
T76 10559-10721 Sentence denotes To verify biochemically that S209 is an IKKβ substrate, we performed 32P-labeling in vitro kinase assays with recombinant wild-type or S209A mutant RPS3 proteins.
T77 10722-10831 Sentence denotes Compared with the wild-type protein, the S209A mutation reduced IKKβ–mediated RPS3 phosphorylation (Fig. 4c).
T78 10832-10958 Sentence denotes There might be alternative phosphorylation site(s) under these conditions given modest residual phosphorylated RPS3 (Fig. 4c).
T79 10959-11130 Sentence denotes RPS3 S209 does not fall within a conventional IKK recognition motif, but rather resides in a sequence motif (XXXpS/TXXE), potentially recognized by casein kinase II (CK2).
T80 11131-11291 Sentence denotes Although IKKβ kinase can display a CK2-like phosphorylation specificity29, no CK2 protein was detectable in our recombinant IKK proteins (Supplementary Fig. 6).
T81 11292-11430 Sentence denotes Thus, RPS3 S209 phosphorylation was due to the alternate specificity of the IKKβ kinase rather than any trace amount of CK2 bound to IKKs.
T82 11431-11624 Sentence denotes To determine whether S209 is the critical site at which IKKβ phosphorylates RPS3 in living cells, we transfected the wild-type or S209A mutant Flag-RPS3 alone, or together with IKKβ into cells.
T83 11625-11864 Sentence denotes Indeed, we observed that overexpressing IKKβ enhanced Flag-RPS3 phosphorylation, but phosphorylation was effectively eliminated by alanine substitution indicating that S209 is the predominant target site for IKKβ phosphorylation (Fig. 4d).
T84 11865-12032 Sentence denotes We next generated a phospho-S209 RPS3 antibody and confirmed that endogenous RPS3 was phosphorylated at S209 in a time-dependent manner upon TNF stimulation (Fig. 4e).
T85 12033-12114 Sentence denotes Thus, the RPS3 C-terminal tail potentially contains an important regulatory site.
T86 12116-12162 Sentence denotes Phosphorylation of RPS3 and its NF-κB function
T87 12163-12283 Sentence denotes We next examined whether S209 phosphorylation plays a role in the nuclear translocation of RPS3 during NF-κB activation.
T88 12284-12551 Sentence denotes Subcellular fractions from either wild-type or S209A mutant RPS3-transfected cells were prepared and blotted for heat-shock protein 90 (hsp90), a cytoplasmic protein, and poly (ADP-ribose) polymerase (PARP), a nuclear protein, confirming a clean separation (Fig. 5a).
T89 12552-12645 Sentence denotes As expected, PMA+I stimulation triggered wild-type Flag-RPS3 nuclear translocation (Fig. 5a).
T90 12646-12715 Sentence denotes However, RPS3 (S209A) nuclear translocation was attenuated (Fig. 5a).
T91 12716-12815 Sentence denotes We also tested the impact of activating NF-κB by overexpressing IKKβ on RPS3 nuclear translocation.
T92 12816-12993 Sentence denotes IKKβ overexpression activated NF-κB measured by luciferase assays (Supplementary Fig. 7), and also induced the nuclear translocation of wild-type, but not S209A, RPS3 (Fig. 5b).
T93 12994-13111 Sentence denotes These data suggest that S209 phosphorylation is critical for the NF-κB activation-induced RPS3 nuclear translocation.
T94 13112-13400 Sentence denotes To examine the role of S209 phosphorylation of RPS3 to its NF-κB function6, 7, 30, we silenced endogenous RPS3 expression using an siRNA that targets the 3′ untranslated region (3′ UTR) of RPS3 mRNA, followed by complementation with either wild-type or S209A mutant RPS3 via transfection.
T95 13401-13609 Sentence denotes As expected, RPS3 siRNA severely reduced endogenous RPS3 abundance compared to NS siRNA, but did not affect the robust expression of Flag-tagged RPS3 from a transfected construct lacking the 3′ UTR (Fig. 5c).
T96 13610-13726 Sentence denotes We also found that RPS3 knockdown reduced TNF-induced expression of an Ig κB-driven luciferase construct6 (Fig. 5d).
T97 13727-13908 Sentence denotes The impaired luciferase signal caused by RPS3 deficiency was completely restored by transfecting wild-type, but not by S209A RPS3 (Fig. 5d), despite equivalent expression (Fig. 5c).
T98 13909-14179 Sentence denotes Moreover, the failure of S209A RPS3 to restore luciferase activity did not result from defective translation because the transient overexpression of green fluorescent protein (GFP) was comparable in cells complemented with wild-type or S029A RPS3 (Supplementary Fig. 8).
T99 14180-14312 Sentence denotes Taken together, these data suggest that RPS3 S209 phosphorylation is critical for NF-κB activity involving the canonical Ig κB site.
T100 14313-14496 Sentence denotes We next used chromatin immunoprecipitation to determine whether S209 phosphorylation affects RPS3 and p65 recruitment to specific κB sites in intact chromatin during NF-κB activation.
T101 14497-14681 Sentence denotes In RPS3 knockdown cells, PMA+I stimulated the recruitment of ectopically expressed, Flag-tagged wild-type, but not S209A RPS3 to the κB sites of the NFKBIA and IL8 promoters (Fig. 5e).
T102 14682-14808 Sentence denotes While expressing RPS3 S209A had no impact on p65 nuclear translocation, it substantially attenuated p65 recruitment (Fig. 5e).
T103 14809-15003 Sentence denotes Additional experiments revealed that p65 attraction to RPS3-independent NF-κB target gene promoters such as CD25 was increased (Supplementary Fig. 9), consistent with our previous observations6.
T104 15004-15151 Sentence denotes There was no significant Flag-RPS3 or p65 recruitment to ACTB promoter lacking κB sites (Fig. 5e), suggesting the recruitment was κB site-specific.
T105 15152-15261 Sentence denotes Thus, the recruitment of RPS3 as well as the contingent recruitment of p65 to key promoters depended on S209.
T106 15262-15528 Sentence denotes Interleukin 8 (IL-8) secretion induced by either T cell receptor (TCR) agonist stimulation or PMA+I was decreased as a consequence of reduced RPS3/p65 recruitment to the IL8 κB sites in the presence of S209A mutant compared to wild-type RPS3 (Supplementary Fig. 10).
T107 15529-15661 Sentence denotes However, cell surface CD25 expression was comparable between the wild-type and S209A RPS3 transfected cells (Supplementary Fig. 11).
T108 15662-15795 Sentence denotes Therefore, RPS3 S209 phosphorylation by IKKβ is apparently required for RPS3 in directing NF-κB to a specific subset of target genes.
T109 15797-15841 Sentence denotes NleH1 inhibits RPS3 phosphorylation in vitro
T110 15842-15944 Sentence denotes EHEC pathogens are important causative agents of both foodborne disease and pediatric renal failure31.
T111 15945-16103 Sentence denotes EHEC utilize T3SS to inject effector proteins directly into intestinal epithelial cells32, a subset of which inhibit NF-κB-dependent innate responses9, 33-38.
T112 16104-16253 Sentence denotes The E. coli O157:H7 EDL933 effector protein NleH1 binds to and attenuates RPS3 nuclear translocation, thus impairing RPS3-dependent NF-κB signaling9.
T113 16254-16344 Sentence denotes We therefore hypothesized that NleH1 may function by inhibiting RPS3 S209 phosphorylation.
T114 16345-16488 Sentence denotes As expected, transfecting increasing amounts of NleH1-HA plasmid blocked TNFα-induced NF-κB activation in a dose-dependent manner (Fig. 6a-b)9.
T115 16489-16615 Sentence denotes Remarkably, NleH1 reduced both TNF-induced, as well as basal RPS3 phosphorylation to roughly 20% of vehicle control (Fig. 6c).
T116 16616-16793 Sentence denotes Expressing NleH1 does not interfere with either TNF-induced IKK activation or IκBα degradation, consistent with the lack of NleH1 impact on p65 nuclear translocation9 (Fig. 6c).
T117 16794-17038 Sentence denotes To determine if NleH1 inhibits RPS3 phosphorylation, we infected HeLa cells with E. coli O157:H7 strains possessing or lacking either nleH1 (ΔnleH1) or with a strain lacking a functional T3SS unable to inject NleH1 into mammalian cells (ΔescN).
T118 17039-17166 Sentence denotes In uninfected cells, TNF-treatment stimulated a ∼7-fold increase in RPS3 S209 phosphorylation, peaking at 30 minutes (Fig. 6d).
T119 17167-17292 Sentence denotes By contrast, RPS3 S209 phosphorylation was substantially impaired in cells infected with wild-type E. coli O157:H7 (Fig. 6d).
T120 17293-17411 Sentence denotes However, TNF-induced RPS3 S209 phosphorylation was unimpaired in cells infected with either ΔnleH1 or ΔescN (Fig. 6d).
T121 17412-17554 Sentence denotes We showed previously that wild-type, but not ΔnleH1 or ΔescN E. coli O157:H7 significantly attenuated TNF-induced RPS3 nuclear translocation9.
T122 17555-17793 Sentence denotes The parallel between RPS3 phosphorylation and its nuclear translocation during E. coli infection provides evidence in the context of an NF-κB-dependent disease process that RPS3 S209 phosphorylation is important for nuclear translocation.
T123 17794-17970 Sentence denotes Our discovery that NleH1 inhibits RPS3 S209 phosphorylation suggested that it should also blocks RPS3-dependent NF-κB target gene transcription (e.g. IL8, NFKBIA, and TNFAIP3).
T124 17971-18162 Sentence denotes Indeed, these genes were only modestly upregulated in cells infected with wild-type E. coli O157:H7, but significantly induced in cells infected with either ΔnleH1 or ΔescN strains (Fig. 6e).
T125 18163-18302 Sentence denotes In contrast, deleting nleH1 had no impact on the expression of RPS3-independent genes, including CD25 and TNFSF13B (Supplementary Fig. 12).
T126 18303-18514 Sentence denotes Together these results demonstrate that NleH1 specifically inhibits the protective immune response by directly blocking RPS3 S209 phosphorylation and thereby impairing critical RPS3-dependent NF-κB target genes.
T127 18516-18564 Sentence denotes NleH1 inhibits RPS3 S209 phosphorylation in vivo
T128 18565-18748 Sentence denotes We previously utilized a gnotobiotic piglet infection model to determine that piglets infected with ΔnleH1 mutant died more rapidly than those infected with wild-type E. coli O157:H7.
T129 18749-18914 Sentence denotes Piglets infected with ΔnleH1 displayed clinical disease consistent with a robust inflammatory response, but with reduced bacterial colonization and little diarrhea9.
T130 18915-19122 Sentence denotes While seemingly paradoxical, based on our cell culture data (Fig. 6d), we hypothesized that NleH1 blocked RPS3 S209 phosphorylation in vivo, thereby preventing RPS3 nuclear translocation in infected piglets.
T131 19123-19237 Sentence denotes We isolated piglet colons at necropsy, and subjected them to immunohistochemistry using our phospho-RPS3 antibody.
T132 19238-19481 Sentence denotes Consistent with in vitro data, piglets infected with wild-type E. coli O157:H7 exhibited diffuse and low intensity phospho-RPS3 staining, whereas in piglets infected with ΔnleH1 mutant, phospho-RPS3 expression was florid and intense (Fig. 6f).
T133 19482-19645 Sentence denotes These data demonstrate that NleH1 inhibits RPS3 S209 phosphorylation both in vitro and in vivo, which might benefit the bacterium in colonization and transmission.
T134 19647-19692 Sentence denotes NleH1 steers the IKKβ substrate specificities
T135 19693-19789 Sentence denotes NleH1 is an autophosphorylated serine-threonine kinase, which depends on the lysine 159 (K159)9.
T136 19790-20091 Sentence denotes To explore the mechanism by which NleH1 inhibits RPS3 S209 phosphorylation, we first performed an in vitro kinase assay with purified wild-type His-NleH1 protein and a mutant His-NleH1 (K159A) protein, confirming that NleH1 is autophosphorylated and the K159A is an NleH1 kinase-dead mutant (Fig. 7a).
T137 20092-20274 Sentence denotes To examine whether the kinase activity is required for NleH1 to inhibit IKKβ phosphorlyation of RPS3 on S209, we ectopically expressing either wild-type or K159A NleH1 in 293T cells.
T138 20275-20414 Sentence denotes Wild-type NleH1 expression significantly reduced TNF-induced RPS3 S209 phosphorylation, whereas the K159A mutant failed to do so (Fig. 7b).
T139 20415-20505 Sentence denotes Thus NleH1 kinase activity is required to protect RPS3 from IKKβ-mediated phosphorylation.
T140 20506-20781 Sentence denotes Citrobacter rodentium is a mouse pathogen that shares pathogenic strategies with E. coli 39, most notably for our investigation, C. rodentium NleH inhibited RPS3 nuclear translocation and RPS3-dependent NF-κB luciferase activity to an extent equivalent to E. coli NleH1 (ref.
T141 20782-20785 Sentence denotes 9).
T142 20786-20882 Sentence denotes We assayed RPS3 S209 phosphorylation in HeLa cells infected with different C. rodentium strains.
T143 20883-20989 Sentence denotes In uninfected cells, TNF-treatment stimulated a ∼3.5-fold increase in RPS3 S209 phosphorylation (Fig. 7c).
T144 20990-21103 Sentence denotes Such augmentation of RPS3 phosphorylation was reduced by about 60% by wild-type C. rodentium infection (Fig. 7c).
T145 21104-21229 Sentence denotes However, RPS3 phosphorylation was enhanced when cells were infected with a C. rodentium strain lacking NleH (Fig. 7c, ΔnleH).
T146 21230-21396 Sentence denotes We further examined the role of NleH1 kinase activity using the C. rodentium ΔnleH strain as a background on which to express either wild-type or K159A E. coli NleH1.
T147 21397-21582 Sentence denotes Complementing ΔnleH mutant with wild-type NleH1 almost abolished TNF-induced RPS3 S209 phosphorylation whereas complementing with K159A failed to inhibit RPS3 phosphorylation (Fig. 7c).
T148 21583-21697 Sentence denotes Collectively, these results demonstrate that NleH1 kinase activity is required to block RPS3 S209 phosphorylation.
T149 21698-21896 Sentence denotes We next examined whether the inhibitory activity of NleH1 is sufficiently robust to impair the strong nuclear translocation of RPS3 trigged by the constitutively-active IKKβ (IKKβ [SSEE]) (Fig. 2d).
T150 21897-22067 Sentence denotes We found that ectopically expressing either wild-type or SSEE IKKβ proteins, triggered more RPS3 nuclear translocation than the kinase-dead IKKβ (SSAA) protein (Fig. 7d).
T151 22068-22181 Sentence denotes RPS3 nuclear accumulation was substantially retarded by infecting cells with wild-type E. coli O157:H7 (Fig. 7d).
T152 22182-22349 Sentence denotes In contrast, infecting with either ΔnleH1 or ΔescN strains only slightly impaired RPS3 nuclear translocation in either IKKβ- or IKKβ (SSEE)-expressing cells (Fig. 7d).
T153 22350-22501 Sentence denotes As expected, E. coli infections did not affect the RPS3 nuclear translocation in IKKβ (SSAA)-expressing cells, where NF-κB signaling was low (Fig. 7d).
T154 22502-22647 Sentence denotes Thus, during infection NleH1 is sufficiently potent to inhibit RPS3 nuclear translocation even in cells expressing constitutively-activated IKKβ.
T155 22648-22764 Sentence denotes We examined whether NleH1 could directly phosphorylate IKKβ thus inhibiting IKKβ-mediated RPS3 S209 phosphorylation.
T156 22765-22974 Sentence denotes We performed in vitro kinase assays using immunoprecipitated Flag-IKKβ (K44A) as substrate and recombinant His-NleH1 as kinase, so that IKKβ autophosphorylation would not obscure NleH1-induced phosphorylation.
T157 22975-23102 Sentence denotes However, we did not observe any detectable 32P incorporation in IKKβ (Supplementary Fig. 13), thus ruling out this possibility.
T158 23103-23189 Sentence denotes We then tested the hypothesis that NleH1 could alter the IKKβ substrate specificities.
T159 23190-23282 Sentence denotes To this end, we performed in vitro kinase assays using both CK2 and IKK substrates for IKKβ.
T160 23283-23451 Sentence denotes As expected, IKKβ phosphorylated RPS3 (Fig. 7e, lane 7) and GST-IκBα (1-54) protein (Fig. 7e, lane 9), demonstrating it harbors either CK2 or IKK substrate specificity.
T161 23452-23652 Sentence denotes Preincubation of IKKβ with NleH1 reduced IKKβ-mediated RPS3 phosphorylation, i.e. the CK2 kinase specificity, but not IKKβ-mediated GST-IκBα phosphorylation, i.e. the IKK kinase specificity (Fig. 7e).
T162 23653-23769 Sentence denotes Control experiments revealed no NleH1-mediated phosphorylation or autophosphorylation of RPS3 or GST-IκBα (Fig. 7e).
T163 23770-23992 Sentence denotes Taken together, NleH1 blocks the CK2 substrate specificity of IKKβ thus inhibiting the IKKβ-mediated RPS3 S209 phosphorylation thus representing a novel strategy by E. coli O157:H7 to alter the host innate immune response.
T164 23994-24004 Sentence denotes Discussion
T165 24005-24114 Sentence denotes RPS3 was previously demonstrated to function as an integral subunit conferring NF-κB regulatory specificity6.
T166 24115-24252 Sentence denotes Here we sought to elucidate how NF-κB activation signaling triggers RPS3 to translocate and participate in NF-κB function in the nucleus.
T167 24253-24448 Sentence denotes We demonstrate that IKKβ-mediated RPS3 S209 phosphorylation represents a critical determinant in governing its nuclear import thus unveiling a novel mechanism behind NF-κB regulatory specificity.
T168 24449-24573 Sentence denotes IKKβ is the major kinase that phosphorylates IκBs in the classical NF-κB pathway, leading to their subsequent degradation40.
T169 24574-24681 Sentence denotes Strikingly, RPS3 possesses not any consensus IKK motif; instead, S209 is centered in a consensus CK2 motif.
T170 24682-24855 Sentence denotes The recent observation that human IKKβ displayed CK2-like phosphorylation specificity29 coincides with our evidence that recombinant IKKβ, but not IKKα, phosphorylated RPS3.
T171 24856-25006 Sentence denotes We found this phosphorylation is a critical modulation for RPS3 nuclear translocation (via importin-α) and engagement in specific NF-κB transcription.
T172 25007-25299 Sentence denotes CK2 was previously shown to phosphorylate p65 and to bind to and phosphorylate IKKβ41-43, however, we ruled out the possibility that the IKKβ-bound CK2 could account for the observed RPS3 phosphorylation because no CK2 was detected in the IKKβ preparations used for the in vitro kinase assay.
T173 25300-25486 Sentence denotes Because RPS3 only harbors the CK2 motif and not a traditional IKK motif, this RPS3 regulatory function could explain why IKK harbors the alternative substrate phosphorylation capability.
T174 25487-25686 Sentence denotes More importantly, our study has elucidated how RPS3 is biochemically integrated into NF-κB activation signaling in a manner that is pivotal for the pathogenesis of foodborne pathogen E. coli O157:H7.
T175 25687-25807 Sentence denotes IKKβ-mediated RPS3 S209 phosphorylation is a critical target modulated by this pathogen to subvert host NF-κB signaling.
T176 25808-25973 Sentence denotes The bacterial effector NleH1 specifically binds to RPS3 once injected into host cells and profoundly suppresses NF-κB and its attendant protective immune responses9.
T177 25974-26157 Sentence denotes Our data now show that NleH1 selectively inhibits RPS3 phosphorylation, thus retarding its nuclear translocation and subsequent NF-κB function, without altering other NF-κB signaling.
T178 26158-26294 Sentence denotes Although NleH1 did not directly phosphorylate IKKβ, its kinase activity was required to inhibit IKKβ-mediated RPS3 S209 phosphorylation.
T179 26295-26524 Sentence denotes Many bacteria pathogens have products that target key kinases to inactivate them in host cells, whereas E. coli O157:H7 employed NleH1 to steer the substrate specificity of IKKβ thus specifically fine-tuning host NF-κB signaling.
T180 26525-26637 Sentence denotes This could represent a novel strategy to fine-tune host NF-κB signaling that could be shared by other pathogens.
T181 26638-26738 Sentence denotes These data provide new insights into the poorly understood action mechanism for most T3SS effectors.
T182 26739-26923 Sentence denotes NleH1 attenuates the transcription of RPS3-dependent, but not all, NF-κB target genes, in particular those genes associated with acute proinflammatory responses, including IL8 and TNF.
T183 26924-27159 Sentence denotes In contrast, NleH1 does not block NF-κB p65 nuclear translocation, which suggests that certain p65-dependent but RPS3-independent NF-κB target genes might thus be beneficial for E. coli O157:H7 to replicate and disseminate in the host.
T184 27160-27347 Sentence denotes By selectively inhibiting RPS3 and its attendant NF-κB function with NleH1, the pathogen achieves the ability to increase colonization and diarrhea yet limiting the mortality of the host.
T185 27348-27605 Sentence denotes This seemingly paradoxical combination of effects make sense when one considers that increased bacterial load and diarrhea together with survival of the infected host would promote the spreading of the bacteria among a population of susceptible individuals.
T186 27606-27744 Sentence denotes Such complex and paradoxical pathological effects that influence the spread of disease are often poorly understood at the molecular level.
T187 27745-27981 Sentence denotes Our data elucidate how alterations in selective NF-κB function, achieved by impeding RPS3, but not altering p65 nuclear translocation, can influence specific cytokines that affect bacterial colonization, diarrhea diseases and mortality.
T188 27982-28180 Sentence denotes It may be fruitful in attempting to understand other infectious and autoimmune diseases involving NF-κB to consider selective effects of subunits such as RPS3 in addition to global NF-κB inhibition.
T189 28182-28189 Sentence denotes Methods
T190 28191-28209 Sentence denotes Cells and Reagents
T191 28210-28401 Sentence denotes Jurkat E6.1, HEK293T and HeLa cells were cultured in RPMI 1640 and DMEM supplemented with 10% fetal calf serum, 2 mM glutamine, and 100 U/ml each of penicillin and streptomycin, respectively.
T192 28402-29063 Sentence denotes IκBα (C-21, sc-371), p65 (C-20, sc-372), and phospho-threonine (H-2, sc-5267) antibodies were from Santa Cruz Biotechnology; β-actin (AC-15, A5441), Flag (M2, F3165), HA (HA-7, H3663), importin-α (IM-75, I1784), and importin-β (31H4, I2534) antibodies were from Sigma; PARP (C2-10, 556362), IKKα (B78-1, 556532), and IKKβ (24, 611254) antibodies were from BD Pharmingen; CK2α (31, 611610) and Hsp90 (68, 610418) antibodies were from BD Transduction Laboratories; phospho-IκBα (5A5, 9246S) and phospho-IKKα/β (16A6, 2697S) antibodies were from Cell Signaling Technology; phospho-serine (AB1603) and phospho-tyrosine (4G10, 05-777) antibodies were from Millipore.
T193 29064-29130 Sentence denotes The rabbit polyclonal RPS3 antiserum was as described previously6.
T194 29131-29296 Sentence denotes The rabbit polyclonal antibody specific for S209 phosphorylated RPS3 was generated and affinity purified by Primm Biotech using the peptide NH2-CKPLPDHV(Sp)IVE-COOH.
T195 29298-29316 Sentence denotes Plasmid Constructs
T196 29317-29406 Sentence denotes The Flag-IKKβ (SSEE), Flag-IKKβ (SSAA), and HA-IκBα (SSAA) constructs were provided by C.
T197 29407-29432 Sentence denotes Wu (NCI, Bethesda) and U.
T198 29433-29476 Sentence denotes Siebenlist (NIAID, Bethesda), respectively.
T199 29477-29553 Sentence denotes The HA-IκBα and IKKβ (K44A)-Flag plasmids were purchased from Addgene44, 45.
T200 29554-29643 Sentence denotes The Flag-RPS3, GST-RPS3, HA-RPS3, VN-HA, NleH1-HA plasmids were described previously6, 9.
T201 29644-29877 Sentence denotes The point mutants of RPS3 were generated by site-directed mutagenesis using the Quick Change Kit (Stratagene) with primers forward 5′-CTGCCTGACCACGTGGCCATTGTGGAACCCAAA-3′ and reverse 5′-TTTGGGTTCCACAATGGCCACGTGGTCAGGCAG-3′ for S209A.
T202 29878-29922 Sentence denotes All mutants were verified by DNA sequencing.
T203 29924-29944 Sentence denotes 32P in vivo Labeling
T204 29945-30067 Sentence denotes HEK 293T cells were labeled with 2 mCi/ml 32P-orthophosphate (Perkin Elmer) in phosphate-free medium (Invitrogen) for 2 h.
T205 30068-30165 Sentence denotes Cells were then left untreated or treated with TNF (50 ng/ml, R&D Systems) for indicated periods.
T206 30166-30246 Sentence denotes Cell lysates were prepared and used for immunoprecipitations with RPS3 antibody.
T207 30248-30269 Sentence denotes In Vitro Kinase Assay
T208 30270-30380 Sentence denotes Kinase-active recombinant IKKβ and IKKα proteins were purchased from Active Motif and Millipore, respectively.
T209 30381-30521 Sentence denotes Bacterially purified glutathione S-transferase (GST), GST-IκBα (1-54), wild type, mutant GST-RPS3, or RPS3 proteins were used as substrates.
T210 30522-30588 Sentence denotes The in vitro kinase assay was performed as previously described29.
T211 30589-30907 Sentence denotes Briefly, enzyme (100 ng) and substrate (2 μg) were co-incubated in IKK reaction buffer (25 mM Tris–HCl [pH 8.0], 50 mM KCl, 10 mM MgCl2, 1 mM DTT, 1 mM Na3VO4, 1 mM ATP) or NleH1 reaction buffer (50 mM Tris-HCl [pH 7.6], 5 mM MgCl2, 1 mM DTT, 1 mM ATP) with 0.5 μCi 32P-γ-ATP (GE Healthcare) added at 37 °C for 30 min.
T212 30908-30982 Sentence denotes The reactions were resolved by SDS–PAGE and visualized by autoradiography.
T213 30984-31001 Sentence denotes LC-MS/MS Analysis
T214 31002-31155 Sentence denotes GST or GST-RPS3 was incubated with recombinant IKKβ protein as described above in an in vitro kinase assay reaction conducted without 32P-γ-ATP labeling.
T215 31156-31261 Sentence denotes The reaction was separated by SDS-PAGE, and the protein gel was stained with Colloidal Blue (Invitrogen).
T216 31262-31428 Sentence denotes The corresponding protein fragments were excised and subjected to trypsin digestion and LC-MS/MS at the Yale Cancer Center Mass Spectrometry Resource (New Haven, CT).
T217 31430-31451 Sentence denotes RNAi and Transfection
T218 31452-31661 Sentence denotes The siRNA (sense-strand sequence) IKKα, 5′-AUGACAGAGAAUGAUCAUGUUCUGC -3′; IKKβ, 5′-GCAGCAAGGAGAACAGAGGUUAAUA -3′; IκBα, 5′-GAGCUCCGAGACUUUCGAGGAAAUA -3′; RPS3-3′ UTR, 5′-GGAUGUUGCUCUCUAAAGACC -3′ (Invitrogen).
T219 31662-31772 Sentence denotes Transient transfection of siRNA and DNA constructs into Jurkat cells and 293T cells was described previously6.
T220 31774-31799 Sentence denotes Subcellular Fractionation
T221 31800-31896 Sentence denotes Subcellular fractionation was performed by differential centrifugation as previously described6.
T222 31897-32103 Sentence denotes Briefly, cells were resuspended in ice-cold Buffer A (10 mM HEPES pH 7.9, 10 mM KCl, 1.5 mM MgCl2, 0.1 mM EDTA, 0.5 mM DTT, 0.4 % NP-40, 0.5 mM PMSF, complete protease inhibitor cocktail) at 4 °C for 5 min.
T223 32104-32212 Sentence denotes Lysates were centrifuged at 4 °C, 500 × g for 3 min, and supernatants were collected as cytosolic fractions.
T224 32213-32404 Sentence denotes Pellets were incubated in Buffer C (20 mM HEPES pH7.9, 420 mM NaCl, 1.5 mM MgCl2, 25% glycerol, 0.5 mM PMSF, 0.2 mM EDTA, 0.5 mM DTT, complete protease inhibitor cocktail) at 4 °C for 10 min.
T225 32405-32508 Sentence denotes Supernatants were collected as nuclear fractions following a centrifuge at 4 °C, 13,800 × g for 10 min.
T226 32510-32541 Sentence denotes Luciferase Reporter Gene Assays
T227 32542-32614 Sentence denotes Luciferase reporter gene assays were performed as previously described6.
T228 32615-32801 Sentence denotes Briefly, cells were cotransfected at a ratio of 10:1 with various promoter-driven firefly luciferase constructs to the Renilla luciferase pTKRL plasmid, together with indicated plasmids.
T229 32802-32884 Sentence denotes Cells were cultured for 1–2 days and then stimulated in triplicate before harvest.
T230 32885-32947 Sentence denotes Lysates were analyzed using the Dual-Luciferase Kit (Promega).
T231 32949-32985 Sentence denotes Chromatin Immunoprecipitation (ChIP)
T232 32986-33037 Sentence denotes ChIP assays was performed as previously described6.
T233 33038-33167 Sentence denotes The primers used to amplify the promoter region adjacent to the κB sites of IL8 and NFKBIA, as well as ACTB have been described6.
T234 33169-33198 Sentence denotes Immunofluorescence Microscopy
T235 33199-33258 Sentence denotes Confocal microscopy was performed as previously described6.
T236 33259-33356 Sentence denotes Briefly, cells were fixed with 4 % paraformaldehyde in PBS and then Cellspin mounted onto slides.
T237 33357-33643 Sentence denotes The fixed cells were then permeabilized with 0.05 % Triton X-100 in PBS and stained with FITC-conjugated rabbit anti-RPS3 antibodies (Primm Biotech), or AlexaFluor 594-conjugated rat anti-Flag antibodies (BD) for 40 min together with 1 μg/ml of Hoechst 33342 (Sigma) for 5 min at 25 °C.
T238 33644-33739 Sentence denotes The slides were then rinsed with PBS three times and cover mounted for fluorescence microscopy.
T239 33741-33775 Sentence denotes Immunoprecipitation and immunoblot
T240 33776-34105 Sentence denotes The cells were harvested and lysed on ice by 0.4 ml of the modified RIPA buffer (50 mM Tris-HCl [pH 7.4], 1% NP-40, 0.25% Na-deoxycholate, 150 mM NaCl, 1 mM EDTA, 1 mM PMSF, 1 mM Na3VO4, 1 mM NaF) supplemented with 1 × protease inhibitor cocktail (Roche) and 1 × phosphatase inhibitor cocktail set I (EMD Biosciences) for 30 min.
T241 34106-34197 Sentence denotes The lysates were centrifuged at 10,000 × g at 4 °C for 10 min to remove insoluble material.
T242 34198-34403 Sentence denotes After normalizing protein concentrations, lysates were subjected to immunoprecipitation by adding 10 mg/ml appropriate antibody plus 30 ml of protein G-agarose (Roche), and rotated for at least 2 h at 4°C.
T243 34404-34551 Sentence denotes The precipitates were washed at least five times with cold lysis buffer followed by separation by SDS-PAGE under reduced and denaturing conditions.
T244 34552-34697 Sentence denotes Nitrocellulose membranes were blocked in 5 % nonfat milk in 0.1 % PBS-Tween 20 (PBS-T), probed with specific antibodies as described previously6.
T245 34698-34868 Sentence denotes For immunoblotting of phosphorylated proteins, gels were transferred to methanol-treated polyvinylidene chloride membranes, retreated with methanol, and dried for 30 min.
T246 34869-35026 Sentence denotes Blots were blocked in 5 % bovine serum albumin in 0.1 % Tris buffered saline-Tween 20 (TBS-T), and probed with specific antibodies as described previously46.
T247 35027-35129 Sentence denotes Bands were imaged by the Super Signaling system (Pierce) according to the manufacturer's instructions.
T248 35131-35136 Sentence denotes ELISA
T249 35137-35338 Sentence denotes The amount of IL-8 present in supernatants collected from Jurkat cell culture was measured using a Human Interleukin-8 ELISA Ready-SET-Go kit (eBioscience) according to the manufacturer's instructions.
T250 35340-35355 Sentence denotes Cell Infections
T251 35356-35451 Sentence denotes HeLa cells were infected with E. coli O157:H7 or C. rodentium strains as described previously9.
T252 35453-35473 Sentence denotes Immunohistochemistry
T253 35474-35562 Sentence denotes Gnotobiotic piglets were infected with E. coli O157:H7 strains as described previously9.
T254 35563-35638 Sentence denotes Spiral colon specimens were collected at necropsy and embedded in paraffin.
T255 35639-35752 Sentence denotes Paraffin sectioning and immunohistochemical staining using phospho-RPS3 antibody were performed by Histoserv Inc.
T256 35754-35776 Sentence denotes Supplementary Material
T257 35777-35778 Sentence denotes 1

ICD10

Id Subject Object Predicate Lexical cue
T10693 12402-12407 http://purl.bioontology.org/ontology/ICD10/R57.9 denotes shock

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T562 0-4 Protein denotes IKKβ
T563 5-20 Phosphorylation denotes phosphorylation
T564 21-30 Regulation denotes regulates
T565 31-35 Protein denotes RPS3
T566 36-43 Entity denotes nuclear
T567 44-57 Localization denotes translocation
T568 186-206 Protein denotes ribosomal protein S3
T569 208-212 Protein denotes RPS3
T570 303-307 Protein denotes RPS3
T571 308-315 Entity denotes nuclear
T572 316-329 Localization denotes translocation
T573 333-342 Regulation denotes regulated true
T574 364-368 Protein denotes IKKβ
T575 369-384 Phosphorylation denotes phosphorylation
T576 388-398 Entity denotes serine 209
T577 410-417 Positive_regulation denotes crucial
T578 422-426 Protein denotes RPS3
T579 427-434 Entity denotes nuclear
T580 435-447 Localization denotes localization
T581 448-462 Positive_regulation denotes in response to
T582 463-473 Positive_regulation denotes activating
T583 559-564 Protein denotes NleH1
T584 578-587 Negative_regulation denotes inhibited
T585 588-592 Protein denotes RPS3
T586 593-597 Entity denotes S209
T587 598-613 Phosphorylation denotes phosphorylation
T588 618-625 Negative_regulation denotes blocked
T589 626-630 Protein denotes RPS3
T590 771-775 Protein denotes IKKβ
T591 776-785 Regulation denotes dependent
T592 786-798 Protein_modification denotes modification
T593 827-831 Protein denotes RPS3
T1834 1203-1207 Protein denotes RelA
T1835 1209-1212 Protein denotes p65
T1836 1215-1219 Protein denotes RelB
T1837 1221-1226 Protein denotes c-Rel
T1838 1228-1231 Protein denotes p50
T1839 1237-1240 Protein denotes p52
T1840 1294-1314 Protein denotes ribosomal protein S3
T1841 1316-1320 Protein denotes RPS3
T1842 1335-1338 Protein denotes Rel
T1843 1383-1387 Protein denotes RPS3
T1844 1564-1568 Protein denotes RPS3
T1845 1636-1664 Protein denotes immunoglobulin κ light chain
T1846 1670-1680 Gene_expression denotes expression
T1847 1908-1913 Protein denotes NleH1
T1848 1968-1979 Negative_regulation denotes attenuating
T1849 1980-1984 Protein denotes RPS3
T1850 1985-1992 Entity denotes nuclear
T1851 1993-2006 Localization denotes translocation
T1852 2016-2025 Regulation denotes affecting true
T1853 2026-2029 Protein denotes p65
T1854 2030-2042 Localization denotes localization
T1855 2096-2102 Positive_regulation denotes induce true
T1856 2103-2107 Protein denotes RPS3
T1857 2108-2115 Entity denotes nuclear
T1858 2116-2129 Localization denotes translocation
T1859 2220-2227 Binding denotes binding
T1860 2266-2270 Protein denotes RPS3
T1861 2353-2357 Protein denotes RPS3
T1862 2361-2375 Phosphorylation denotes phosphorylated true
T1863 2487-2491 Protein denotes RPS3
T1864 2495-2509 Phosphorylation denotes phosphorylated true
T1865 2672-2676 Protein denotes RPS3
T1866 2727-2760 Protein denotes Inhibitor of κB (IκB) kinase beta
T1867 2762-2766 Protein denotes IKKβ
T1868 2768-2782 Phosphorylation denotes phosphorylated
T1869 2783-2787 Protein denotes RPS3
T1870 2791-2801 Entity denotes serine 209
T1871 2810-2814 Protein denotes RPS3
T1872 2815-2819 Entity denotes S209
T1873 2820-2835 Phosphorylation denotes phosphorylation
T1874 2836-2844 Positive_regulation denotes enhanced
T1875 2849-2860 Binding denotes association
T1876 2878-2887 Positive_regulation denotes mediating
T1877 2888-2892 Protein denotes RPS3
T1878 2932-2939 Entity denotes nuclear
T1879 2940-2953 Localization denotes translocation
T1880 2980-2985 Protein denotes NleH1
T1881 3008-3017 Negative_regulation denotes inhibited
T1882 3018-3022 Protein denotes RPS3
T1883 3023-3027 Entity denotes S209
T2479 3126-3130 Protein denotes RPS3
T2480 3131-3146 Phosphorylation denotes phosphorylation
T2481 3147-3161 Positive_regulation denotes in response to true
T2482 3195-3199 Protein denotes RPS3
T2483 3203-3217 Phosphorylation denotes phosphorylated true
T2484 3345-3349 Protein denotes RPS3
T2485 3363-3377 Phosphorylation denotes phosphorylated true
T2486 3422-3430 Positive_regulation denotes increase
T2487 3434-3451 Phosphorylation denotes 32P-incorporation
T2488 3485-3493 Positive_regulation denotes increase true
T2489 3497-3501 Protein denotes RPS3
T2490 3540-3544 Protein denotes RPS3
T2491 3545-3553 Entity denotes residues
T2492 3559-3573 Phosphorylation denotes phosphorylated true
T2493 3597-3601 Protein denotes RPS3
T2494 3770-3780 Positive_regulation denotes stimulated
T2495 3770-3780 Positive_regulation denotes stimulated
T2496 3787-3802 Phosphorylation denotes phosphorylation
T2497 3807-3817 Protein_catabolism denotes degradaion
T2498 3821-3825 Protein denotes IκBα
T2499 3864-3868 Protein denotes RPS3
T2500 3869-3884 Phosphorylation denotes phosphorylation
T2501 3888-3903 Entity denotes serine residues
T2502 3985-3993 Entity denotes tyrosine
T2503 3998-4007 Entity denotes threonine
T2504 4008-4023 Phosphorylation denotes phosphorylation true
T2505 4008-4023 Phosphorylation denotes phosphorylation true
T2506 4027-4031 Protein denotes RPS3
T3194 4044-4048 Protein denotes RPS3
T3195 4053-4057 Protein denotes IKKβ
T3196 4058-4069 Binding denotes interaction true
T3197 4157-4161 Protein denotes IKKγ
T3198 4190-4194 Protein denotes IKKα
T3199 4199-4203 Protein denotes IKKβ
T3200 4322-4326 Protein denotes RPS3
T3201 4359-4362 Protein denotes p65
T3202 4363-4366 Protein denotes p50
T3203 4367-4371 Protein denotes IκBα
T3204 4431-4440 Positive_regulation denotes activated
T3205 4441-4445 Protein denotes IKKβ
T3206 4457-4461 Binding denotes bind true
T3207 4469-4482 Phosphorylation denotes phosphorylate true
T3208 4483-4487 Protein denotes RPS3
T3209 4522-4531 Gene_expression denotes expressed
T3210 4532-4536 Protein denotes IKKβ
T3211 4541-4545 Protein denotes RPS3
T3212 4546-4556 Binding denotes interacted
T3213 4639-4643 Protein denotes IKKβ
T3214 4644-4648 Protein denotes RPS3
T3215 4649-4660 Binding denotes interaction
T3216 4775-4779 Protein denotes RPS3
T3217 4780-4784 Protein denotes IKKβ
T3218 4785-4796 Binding denotes association
T3219 4809-4818 Positive_regulation denotes augmented
T3220 4871-4880 Positive_regulation denotes following
T3221 4901-4905 Protein denotes RPS3
T3222 4906-4912 Entity denotes serine
T3223 4913-4928 Phosphorylation denotes phosphorylation
T3224 4977-4988 Binding denotes interaction true
T3225 4997-5001 Protein denotes RPS3
T3226 5006-5010 Protein denotes IKKα
T4610 5023-5027 Protein denotes IKKβ
T4611 5031-5039 Positive_regulation denotes required
T4612 5044-5048 Protein denotes RPS3
T4613 5049-5056 Entity denotes nuclear
T4614 5057-5070 Localization denotes translocation
T4615 5094-5098 Protein denotes RPS3
T4616 5099-5103 Protein denotes IKKβ
T4617 5104-5115 Binding denotes interaction
T4618 5119-5127 Positive_regulation denotes required true
T4619 5132-5136 Protein denotes RPS3
T4620 5137-5144 Entity denotes nuclear
T4621 5145-5158 Localization denotes translocation
T4622 5163-5175 Negative_regulation denotes knocked down
T4623 5163-5175 Negative_regulation denotes knocked down
T4624 5176-5180 Protein denotes IKKα
T4625 5184-5188 Protein denotes IKKβ
T4626 5189-5199 Gene_expression denotes expression
T4627 5189-5199 Gene_expression denotes expression
T4628 5265-5272 Positive_regulation denotes induced true
T4629 5273-5277 Protein denotes RPS3
T4630 5278-5285 Entity denotes nuclear
T4631 5286-5295 Localization denotes migration
T4632 5339-5348 Positive_regulation denotes triggered
T4633 5349-5353 Protein denotes RPS3
T4634 5354-5361 Entity denotes nuclear
T4635 5362-5375 Localization denotes translocation
T4636 5456-5460 Protein denotes RPS3
T4637 5461-5468 Entity denotes nuclear
T4638 5469-5482 Localization denotes translocation
T4639 5513-5521 Negative_regulation denotes impaired
T4640 5525-5529 Protein denotes IKKα
T4641 5530-5539 Negative_regulation denotes silencing
T4642 5553-5562 Negative_regulation denotes knockdown
T4643 5566-5570 Protein denotes IKKβ
T4644 5571-5581 Negative_regulation denotes attenuated
T4645 5592-5596 Protein denotes RPS3
T4646 5597-5604 Entity denotes nuclear
T4647 5605-5617 Localization denotes accumulation
T4648 5618-5627 Positive_regulation denotes following
T4649 5707-5717 Gene_expression denotes expression
T4650 5707-5717 Gene_expression denotes expression
T4651 5721-5725 Protein denotes IKKβ
T4652 5735-5739 Protein denotes IKKα
T4653 5745-5754 Positive_regulation denotes necessary true
T4654 5745-5754 Positive_regulation denotes necessary true
T4655 5770-5777 Positive_regulation denotes induced
T4656 5778-5782 Protein denotes RPS3
T4657 5783-5790 Entity denotes nuclear
T4658 5791-5804 Localization denotes translocation
T4659 5850-5853 Protein denotes p65
T4660 5854-5861 Entity denotes nuclear
T4661 5862-5875 Localization denotes translocation
T4662 5880-5887 Negative_regulation denotes blocked
T4663 5946-5953 Entity denotes nuclear
T4664 5954-5967 Localization denotes translocation true
T4665 5971-5975 Protein denotes RPS3
T4666 5997-6007 Gene_expression denotes expressing
T4667 6015-6026 Negative_regulation denotes kinase-dead
T4668 6037-6058 Positive_regulation denotes constitutively-active
T4669 6073-6077 Protein denotes IKKβ
T4670 6105-6109 Positive_regulation denotes SSEE
T4671 6119-6123 Negative_regulation denotes SSAA
T4672 6135-6139 Protein denotes IKKβ
T4673 6140-6147 Positive_regulation denotes induced true
T4674 6140-6147 Positive_regulation denotes induced true
T4675 6154-6163 Regulation denotes dependent
T4676 6164-6174 Protein denotes luciferase
T4677 6218-6222 Protein denotes RPS3
T4678 6223-6231 Localization denotes remained
T4679 6232-6241 Entity denotes cytosolic
T4680 6242-6244 Positive_regulation denotes in
T4681 6245-6249 Protein denotes IKKβ
T4682 6251-6255 Negative_regulation denotes SSAA
T4683 6320-6324 Protein denotes RPS3
T4684 6325-6337 Localization denotes translocated
T4685 6345-6352 Entity denotes nucleus
T4686 6353-6355 Positive_regulation denotes in
T4687 6373-6377 Protein denotes IKKβ
T4688 6379-6383 Positive_regulation denotes SSEE
T4690 6449-6456 Entity denotes nuclear
T4691 6457-6461 Protein denotes RPS3
T4692 6462-6471 Positive_regulation denotes increased true
T4693 6462-6471 Positive_regulation denotes increased true
T4694 6482-6486 Protein denotes IKKβ
T4695 6488-6492 Positive_regulation denotes SSEE
T4696 6523-6527 Protein denotes IKKβ
T4697 6529-6533 Negative_regulation denotes SSAA
T4698 6593-6597 Protein denotes IKKβ
T4699 6610-6619 Positive_regulation denotes necessary
T4700 6639-6643 Protein denotes RPS3
T4701 6644-6651 Entity denotes nuclear
T4702 6652-6665 Localization denotes translocation
T4703 6666-6680 Positive_regulation denotes in response to
T6649 6708-6712 Protein denotes IκBα
T6650 6713-6724 Protein_catabolism denotes degradation true
T6651 6729-6733 Protein denotes RPS3
T6652 6734-6741 Entity denotes nuclear
T6653 6742-6755 Localization denotes translocation true
T6654 6767-6776 Regulation denotes regulates
T6655 6781-6788 Entity denotes nuclear
T6656 6789-6795 Localization denotes import
T6657 6805-6808 Protein denotes Rel
T6658 6825-6829 Protein denotes RPS3
T6659 6891-6898 Entity denotes nuclear
T6660 6899-6912 Localization denotes translocation
T6661 6958-6961 Protein denotes p65
T6662 6962-6975 Localization denotes translocation
T6663 6997-7001 Protein denotes RPS3
T6664 7076-7080 Protein denotes RPS3
T6665 7209-7213 Protein denotes RPS3
T6666 7214-7221 Binding denotes binding
T6667 7239-7248 Positive_regulation denotes essential
T6668 7253-7260 Entity denotes nuclear
T6669 7261-7274 Localization denotes translocation
T6670 7306-7310 Protein denotes IκBα
T6671 7311-7322 Protein_catabolism denotes degradation
T6672 7328-7340 Positive_regulation denotes prerequisite
T6673 7344-7350 Regulation denotes unmask
T6674 7355-7358 Entity denotes NLS
T6675 7362-7365 Protein denotes p65
T6676 7376-7380 Protein denotes RPS3
T6677 7385-7389 Protein denotes IκBα
T6678 7390-7394 Binding denotes bind
T6679 7390-7394 Binding denotes bind
T6680 7398-7401 Protein denotes p65
T6681 7459-7463 Protein denotes IκBα
T6682 7464-7475 Protein_catabolism denotes degradation
T6683 7479-7487 Positive_regulation denotes required true
T6684 7496-7506 Localization denotes liberation
T6685 7510-7514 Protein denotes RPS3
T6686 7532-7543 Binding denotes association true
T6687 7547-7551 Protein denotes RPS3
T6688 7607-7611 Protein denotes IκBα
T6689 7618-7622 Protein denotes IκBα
T6690 7631-7635 Negative_regulation denotes SSAA
T6691 7637-7646 Negative_regulation denotes resistant
T6692 7637-7646 Negative_regulation denotes resistant
T6693 7650-7654 Protein denotes IKKβ
T6694 7655-7662 Positive_regulation denotes induced
T6695 7655-7662 Positive_regulation denotes induced
T6696 7663-7678 Phosphorylation denotes phosphorylation
T6697 7683-7694 Protein_catabolism denotes degradation
T6698 7732-7736 Protein denotes IκBα
T6699 7754-7763 Positive_regulation denotes augmented
T6700 7768-7779 Binding denotes interaction
T6701 7783-7787 Protein denotes RPS3
T6702 7886-7890 Protein denotes RPS3
T6703 7902-7913 Binding denotes association
T6704 7918-7927 Negative_regulation denotes abolished
T6705 7951-7961 Protein_catabolism denotes degradable true
T6706 7962-7966 Protein denotes IκBα
T6707 7997-8001 Protein denotes IκBα
T6708 8034-8044 Negative_regulation denotes precluding true
T6709 8045-8049 Protein denotes RPS3
T6710 8050-8057 Entity denotes nuclear
T6711 8058-8071 Localization denotes translocation
T6712 8090-8094 Protein denotes RPS3
T6713 8106-8117 Binding denotes association true
T6714 8130-8134 Protein denotes RPS3
T6715 8141-8149 Negative_regulation denotes reducing
T6716 8150-8154 Protein denotes IκBα
T6717 8155-8165 Gene_expression denotes expression
T6718 8200-8205 Protein denotes siRNA
T6719 8219-8223 Protein denotes IκBα
T6720 8235-8243 Negative_regulation denotes depleted
T6721 8244-8248 Protein denotes IκBα
T6722 8301-8305 Protein denotes RPS3
T6723 8317-8328 Binding denotes association
T6724 8337-8346 Positive_regulation denotes augmented true
T6725 8378-8385 Entity denotes nuclear
T6726 8386-8390 Protein denotes RPS3
T6727 8391-8399 Localization denotes detected true
T6728 8467-8473 Positive_regulation denotes induce
T6729 8474-8478 Protein denotes IκBα
T6730 8479-8490 Protein_catabolism denotes degradation
T6731 8546-8555 Positive_regulation denotes increased true
T6732 8546-8555 Positive_regulation denotes increased true
T6733 8556-8567 Binding denotes association
T6734 8576-8580 Protein denotes RPS3
T6735 8635-8642 Entity denotes nuclear
T6736 8643-8655 Localization denotes accumulation
T6737 8659-8663 Protein denotes RPS3
T6738 8682-8686 Protein denotes IκBα
T6739 8687-8698 Protein_catabolism denotes degradation
T6740 8803-8811 Positive_regulation denotes promotes true
T6741 8803-8811 Positive_regulation denotes promotes true
T6742 8827-8838 Binding denotes association
T6743 8843-8850 Entity denotes nuclear
T6744 8851-8860 Localization denotes transport
T6745 8864-8868 Protein denotes RPS3
T6746 8875-8879 Protein denotes IκBα
T6747 8880-8891 Protein_catabolism denotes degradation
T6748 8950-8958 Positive_regulation denotes required
T6749 8967-8971 Protein denotes RPS3
T6750 8983-8994 Binding denotes association
T6751 9049-9053 Protein denotes IκBα
T6752 9054-9069 Phosphorylation denotes phosphorylation
T6753 9074-9085 Protein_catabolism denotes degradation
T6754 9127-9132 Positive_regulation denotes cause
T6755 9127-9132 Positive_regulation denotes cause
T6756 9133-9137 Protein denotes RPS3
T6757 9138-9149 Binding denotes association
T6758 9166-9174 Positive_regulation denotes followed
T6759 9178-9185 Entity denotes nuclear
T6760 9186-9199 Localization denotes translocation
T6761 9243-9247 Protein denotes IKKβ
T6762 9248-9263 Phosphorylation denotes phosphorylation
T6763 9267-9271 Protein denotes RPS3
T8531 9287-9291 Protein denotes IKKβ
T8532 9292-9306 Phosphorylation denotes phosphorylates
T8533 9307-9311 Protein denotes RPS3
T8534 9315-9325 Entity denotes serine 209
T8535 9395-9399 Protein denotes IKKβ
T8536 9405-9419 Phosphorylation denotes phosphorylates
T8537 9405-9419 Phosphorylation denotes phosphorylates
T8538 9451-9458 Protein denotes 14-3-3β
T8539 9463-9468 Protein denotes Bcl10
T8540 9552-9556 Protein denotes IKKβ
T8541 9572-9585 Phosphorylation denotes phosphorylate true
T8542 9586-9590 Protein denotes RPS3
T8543 9644-9648 Protein denotes RPS3
T8544 9678-9698 Phosphorylation denotes incorporation of 32P
T8545 9678-9698 Phosphorylation denotes incorporation of 32P
T8546 9702-9719 Phosphorylation denotes autophosphorylatd
T8547 9702-9719 Phosphorylation denotes autophosphorylatd
T8548 9720-9724 Protein denotes IKKα
T8549 9729-9733 Protein denotes IKKβ
T8550 9766-9779 Phosphorylation denotes phosporylated true
T8551 9766-9779 Phosphorylation denotes phosporylated true
T8552 9780-9788 Protein denotes GST-IκBα
T8553 9832-9835 Protein denotes GST
T8554 9888-9892 Protein denotes IKKα
T8555 9896-9900 Protein denotes IKKβ
T8556 9930-9938 Protein denotes GST-RPS3
T8557 9948-9962 Phosphorylation denotes phosphorylated true true
T8558 9948-9962 Phosphorylation denotes phosphorylated true
T8559 9966-9970 Protein denotes IKKβ
T8560 9980-9984 Protein denotes IKKα
T8561 10045-10049 Protein denotes RPS3
T8562 10050-10071 Entity denotes amino acid residue(s)
T8563 10072-10086 Phosphorylation denotes phosphorylated
T8564 10090-10094 Protein denotes IKKβ
T8565 10180-10194 Phosphorylation denotes phosphorylated
T8566 10195-10199 Protein denotes RPS3
T8567 10228-10232 Protein denotes IKKβ
T8568 10233-10247 Phosphorylation denotes phosphorylated
T8569 10248-10252 Entity denotes S209
T8570 10269-10273 Protein denotes RPS3
T8571 10296-10300 Protein denotes RPS3
T8572 10599-10603 Protein denotes IKKβ
T8573 10650-10656 Protein denotes kinase
T8574 10694-10699 Entity denotes S209A
T8575 10700-10706 Regulation denotes mutant
T8576 10707-10711 Protein denotes RPS3
T8577 10763-10768 Entity denotes S209A
T8578 10769-10777 Regulation denotes mutation
T8579 10778-10785 Negative_regulation denotes reduced
T8580 10786-10791 Protein denotes IKKβ–
T8581 10791-10799 Positive_regulation denotes mediated
T8582 10800-10804 Protein denotes RPS3
T8583 10805-10820 Phosphorylation denotes phosphorylation
T8584 10928-10942 Phosphorylation denotes phosphorylated
T8585 10943-10947 Protein denotes RPS3
T8586 10959-10963 Protein denotes RPS3
T8587 11052-11066 Entity denotes sequence motif
T8588 11093-11103 Binding denotes recognized
T8589 11140-11144 Protein denotes IKKβ
T8590 11298-11302 Protein denotes RPS3
T8591 11303-11307 Entity denotes S209
T8592 11308-11323 Phosphorylation denotes phosphorylation
T8593 11328-11331 Positive_regulation denotes due true
T8594 11368-11372 Protein denotes IKKβ
T8595 11452-11456 Entity denotes S209
T8596 11464-11472 Positive_regulation denotes critical true
T8597 11487-11491 Protein denotes IKKβ
T8598 11492-11506 Phosphorylation denotes phosphorylates
T8599 11507-11511 Protein denotes RPS3
T8600 11532-11543 Gene_expression denotes transfected
T8601 11532-11543 Gene_expression denotes transfected
T8602 11574-11583 Protein denotes Flag-RPS3
T8603 11608-11612 Protein denotes IKKβ
T8604 11650-11664 Positive_regulation denotes overexpressing
T8605 11665-11669 Protein denotes IKKβ
T8606 11670-11678 Positive_regulation denotes enhanced
T8607 11679-11688 Protein denotes Flag-RPS3
T8608 11689-11704 Phosphorylation denotes phosphorylation
T8609 11742-11752 Negative_regulation denotes eliminated
T8610 11756-11776 Regulation denotes alanine substitution
T8611 11793-11797 Entity denotes S209
T8612 11833-11837 Protein denotes IKKβ
T8613 11838-11853 Phosphorylation denotes phosphorylation
T8614 11885-11911 Protein denotes phospho-S209 RPS3 antibody
T8615 11942-11946 Protein denotes RPS3
T8616 11951-11965 Phosphorylation denotes phosphorylated
T8617 11969-11973 Entity denotes S209
T8618 11984-11993 Regulation denotes dependent
T8619 12001-12005 Positive_regulation denotes upon
T8620 12043-12047 Protein denotes RPS3
T11311 12116-12131 Phosphorylation denotes Phosphorylation
T11312 12135-12139 Protein denotes RPS3
T11313 12188-12192 Entity denotes S209
T11314 12193-12208 Phosphorylation denotes phosphorylation
T11315 12209-12221 Regulation denotes plays a role true
T11316 12229-12236 Entity denotes nuclear
T11317 12237-12250 Localization denotes translocation
T11319 12331-12336 Entity denotes S209A
T11320 12337-12343 Regulation denotes mutant
T11321 12344-12348 Protein denotes RPS3
T11322 12583-12592 Positive_regulation denotes triggered
T11323 12603-12612 Protein denotes Flag-RPS3
T11324 12613-12620 Entity denotes nuclear
T11325 12621-12634 Localization denotes translocation
T11326 12655-12659 Protein denotes RPS3
T11327 12661-12666 Entity denotes S209A
T11328 12668-12675 Entity denotes nuclear
T11329 12676-12689 Localization denotes translocation
T11330 12694-12704 Negative_regulation denotes attenuated
T11331 12735-12741 Regulation denotes impact true
T11332 12765-12779 Positive_regulation denotes overexpressing
T11333 12780-12784 Protein denotes IKKβ
T11334 12788-12792 Protein denotes RPS3
T11335 12793-12800 Entity denotes nuclear
T11336 12801-12814 Localization denotes translocation
T11337 12816-12820 Protein denotes IKKβ
T11338 12864-12874 Protein denotes luciferase
T11339 12915-12922 Positive_regulation denotes induced true
T11340 12927-12934 Entity denotes nuclear
T11341 12935-12948 Localization denotes translocation
T11342 12978-12982 Protein denotes RPS3
T11343 13018-13022 Entity denotes S209
T11344 13023-13038 Phosphorylation denotes phosphorylation
T11345 13042-13050 Positive_regulation denotes critical
T11346 13076-13083 Positive_regulation denotes induced
T11347 13084-13088 Protein denotes RPS3
T11348 13089-13096 Entity denotes nuclear
T11349 13097-13110 Localization denotes translocation
T11350 13135-13139 Entity denotes S209
T11351 13140-13155 Phosphorylation denotes phosphorylation
T11352 13159-13163 Protein denotes RPS3
T11353 13198-13206 Negative_regulation denotes silenced
T11354 13218-13222 Protein denotes RPS3
T11355 13223-13233 Gene_expression denotes expression
T11356 13301-13305 Protein denotes RPS3
T11357 13378-13382 Protein denotes RPS3
T11358 13387-13399 Gene_expression denotes transfection
T11359 13414-13424 Protein denotes RPS3 siRNA
T11360 13434-13441 Negative_regulation denotes reduced
T11361 13453-13457 Protein denotes RPS3
T11362 13502-13508 Regulation denotes affect true
T11363 13520-13530 Gene_expression denotes expression
T11364 13534-13550 Protein denotes Flag-tagged RPS3
T11365 13629-13633 Protein denotes RPS3
T11366 13634-13643 Negative_regulation denotes knockdown
T11367 13644-13651 Negative_regulation denotes reduced
T11368 13656-13663 Positive_regulation denotes induced
T11369 13664-13674 Gene_expression denotes expression
T11370 13687-13693 Positive_regulation denotes driven
T11371 13694-13704 Protein denotes luciferase
T11372 13731-13739 Negative_regulation denotes impaired
T11373 13740-13750 Protein denotes luciferase
T11374 13758-13764 Positive_regulation denotes caused
T11375 13768-13772 Protein denotes RPS3
T11376 13773-13783 Negative_regulation denotes deficiency
T11377 13811-13823 Gene_expression denotes transfecting
T11378 13852-13856 Protein denotes RPS3
T11379 14040-14054 Gene_expression denotes overexpression
T11380 14058-14083 Protein denotes green fluorescent protein
T11381 14085-14088 Protein denotes GFP
T11382 14151-14155 Protein denotes RPS3
T11383 14220-14224 Protein denotes RPS3
T11384 14225-14229 Entity denotes S209
T11385 14230-14245 Phosphorylation denotes phosphorylation
T11386 14377-14381 Entity denotes S209
T11387 14382-14397 Phosphorylation denotes phosphorylation
T11388 14398-14405 Regulation denotes affects true
T11389 14398-14405 Regulation denotes affects true
T11390 14406-14410 Protein denotes RPS3
T11391 14415-14418 Protein denotes p65
T11392 14419-14430 Binding denotes recruitment
T11393 14419-14430 Binding denotes recruitment
T11394 14500-14504 Protein denotes RPS3
T11395 14505-14514 Negative_regulation denotes knockdown
T11396 14528-14538 Positive_regulation denotes stimulated true
T11397 14528-14538 Positive_regulation denotes stimulated true
T11398 14528-14538 Positive_regulation denotes stimulated true
T11399 14528-14538 Positive_regulation denotes stimulated true
T11400 14543-14554 Binding denotes recruitment
T11401 14543-14554 Binding denotes recruitment
T11402 14543-14554 Binding denotes recruitment
T11403 14543-14554 Binding denotes recruitment
T11404 14570-14579 Gene_expression denotes expressed
T11405 14612-14617 Entity denotes S209A
T11406 14618-14622 Protein denotes RPS3
T11407 14630-14638 Entity denotes κB sites
T11408 14646-14652 Protein denotes NFKBIA
T11409 14657-14660 Protein denotes IL8
T11410 14699-14703 Protein denotes RPS3
T11411 14704-14709 Entity denotes S209A
T11412 14717-14723 Regulation denotes impact true
T11413 14727-14730 Protein denotes p65
T11414 14731-14738 Entity denotes nuclear
T11415 14739-14752 Localization denotes translocation
T11416 14771-14781 Negative_regulation denotes attenuated
T11417 14782-14785 Protein denotes p65
T11418 14786-14797 Binding denotes recruitment
T11419 14846-14849 Protein denotes p65
T11420 14850-14860 Localization denotes attraction
T11421 14864-14868 Protein denotes RPS3
T11422 14899-14908 Entity denotes promoters
T11423 14917-14921 Protein denotes CD25
T11424 14926-14935 Positive_regulation denotes increased
T11425 15029-15038 Protein denotes Flag-RPS3
T11426 15042-15045 Protein denotes p65
T11427 15046-15057 Localization denotes recruitment true
T11428 15046-15057 Localization denotes recruitment true
T11429 15061-15065 Protein denotes ACTB
T11430 15066-15074 Entity denotes promoter
T11431 15142-15150 Regulation denotes specific true
T11432 15162-15173 Localization denotes recruitment
T11433 15177-15181 Protein denotes RPS3
T11434 15208-15219 Localization denotes recruitment
T11435 15223-15226 Protein denotes p65
T11436 15234-15243 Entity denotes promoters
T11437 15244-15252 Regulation denotes depended
T11438 15244-15252 Regulation denotes depended
T11439 15256-15260 Entity denotes S209
T11440 15262-15275 Protein denotes Interleukin 8
T11441 15277-15281 Protein denotes IL-8
T11442 15283-15292 Localization denotes secretion
T11443 15293-15300 Positive_regulation denotes induced
T11444 15341-15352 Positive_regulation denotes stimulation
T11445 15366-15375 Negative_regulation denotes decreased
T11446 15396-15403 Negative_regulation denotes reduced
T11447 15404-15408 Protein denotes RPS3
T11448 15409-15412 Protein denotes p65
T11449 15413-15424 Binding denotes recruitment
T11450 15432-15435 Protein denotes IL8
T11451 15436-15444 Entity denotes κB sites
T11452 15464-15469 Entity denotes S209A
T11453 15499-15503 Protein denotes RPS3
T11454 15551-15555 Protein denotes CD25
T11455 15556-15566 Gene_expression denotes expression
T11456 15614-15618 Protein denotes RPS3
T11457 15619-15630 Gene_expression denotes transfected
T11458 15673-15677 Protein denotes RPS3
T11459 15678-15682 Entity denotes S209
T11460 15683-15698 Phosphorylation denotes phosphorylation
T11461 15699-15701 Positive_regulation denotes by
T11462 15702-15706 Protein denotes IKKβ
T11463 15734-15738 Protein denotes RPS3
T13458 15797-15802 Protein denotes NleH1
T13459 15803-15811 Negative_regulation denotes inhibits
T13460 15812-15816 Protein denotes RPS3
T13461 15817-15832 Phosphorylation denotes phosphorylation
T13462 16148-16153 Protein denotes NleH1
T13463 16154-16159 Binding denotes binds
T13464 16167-16177 Negative_regulation denotes attenuates
T13465 16178-16182 Protein denotes RPS3
T13466 16183-16190 Entity denotes nuclear
T13467 16191-16204 Localization denotes translocation
T13468 16221-16225 Protein denotes RPS3
T13469 16285-16290 Protein denotes NleH1
T13470 16307-16317 Negative_regulation denotes inhibiting
T13471 16318-16322 Protein denotes RPS3
T13472 16323-16327 Entity denotes S209
T13473 16328-16343 Phosphorylation denotes phosphorylation
T13474 16371-16381 Positive_regulation denotes increasing
T13475 16393-16401 Protein denotes NleH1-HA
T13476 16418-16422 Protein denotes TNFα
T13477 16501-16506 Protein denotes NleH1
T13478 16507-16514 Negative_regulation denotes reduced
T13479 16507-16514 Negative_regulation denotes reduced
T13480 16520-16523 Protein denotes TNF
T13481 16524-16531 Positive_regulation denotes induced
T13482 16550-16554 Protein denotes RPS3
T13483 16555-16570 Phosphorylation denotes phosphorylation
T13484 16616-16626 Gene_expression denotes Expressing
T13485 16627-16632 Protein denotes NleH1
T13486 16642-16651 Negative_regulation denotes interfere
T13487 16642-16651 Negative_regulation denotes interfere
T13488 16664-16667 Protein denotes TNF
T13489 16680-16690 Positive_regulation denotes activation
T13490 16694-16698 Protein denotes IκBα
T13491 16699-16710 Protein_catabolism denotes degradation
T13492 16732-16736 Negative_regulation denotes lack
T13493 16740-16745 Protein denotes NleH1
T13494 16746-16752 Regulation denotes impact
T13495 16756-16759 Protein denotes p65
T13496 16760-16767 Entity denotes nuclear
T13497 16768-16781 Localization denotes translocation
T13498 16810-16815 Protein denotes NleH1
T13499 16816-16824 Negative_regulation denotes inhibits true
T13500 16825-16829 Protein denotes RPS3
T13501 16830-16845 Phosphorylation denotes phosphorylation
T13502 16913-16920 Negative_regulation denotes lacking
T13503 16928-16933 Protein denotes nleH1
T13504 16935-16941 Protein denotes ΔnleH1
T13505 17003-17008 Protein denotes NleH1
T13506 17031-17036 Protein denotes ΔescN
T13507 17060-17063 Protein denotes TNF
T13508 17095-17103 Positive_regulation denotes increase
T13509 17107-17111 Protein denotes RPS3
T13510 17112-17116 Entity denotes S209
T13511 17117-17132 Phosphorylation denotes phosphorylation
T13512 17180-17184 Protein denotes RPS3
T13513 17185-17189 Entity denotes S209
T13514 17190-17205 Phosphorylation denotes phosphorylation
T13515 17224-17232 Negative_regulation denotes impaired
T13516 17302-17305 Protein denotes TNF
T13517 17306-17313 Positive_regulation denotes induced
T13518 17314-17318 Protein denotes RPS3
T13519 17319-17323 Entity denotes S209
T13520 17324-17339 Phosphorylation denotes phosphorylation
T13521 17344-17354 Negative_regulation denotes unimpaired true
T13522 17344-17354 Negative_regulation denotes unimpaired true
T13523 17385-17391 Protein denotes ΔnleH1
T13524 17395-17400 Protein denotes ΔescN
T13525 17457-17463 Protein denotes ΔnleH1
T13526 17467-17472 Protein denotes ΔescN
T13527 17503-17513 Negative_regulation denotes attenuated
T13528 17503-17513 Negative_regulation denotes attenuated
T13529 17514-17517 Protein denotes TNF
T13530 17518-17525 Positive_regulation denotes induced
T13531 17526-17530 Protein denotes RPS3
T13532 17531-17538 Entity denotes nuclear
T13533 17539-17552 Localization denotes translocation
T13534 17576-17580 Protein denotes RPS3
T13535 17581-17596 Phosphorylation denotes phosphorylation
T13536 17605-17612 Entity denotes nuclear
T13537 17613-17626 Localization denotes translocation
T13538 17728-17732 Protein denotes RPS3
T13539 17733-17737 Entity denotes S209
T13540 17738-17753 Phosphorylation denotes phosphorylation
T13541 17757-17766 Regulation denotes important
T13542 17771-17778 Entity denotes nuclear
T13543 17779-17792 Localization denotes translocation
T13544 17813-17818 Protein denotes NleH1
T13545 17819-17827 Negative_regulation denotes inhibits
T13546 17828-17832 Protein denotes RPS3
T13547 17833-17837 Entity denotes S209
T13548 17838-17853 Phosphorylation denotes phosphorylation
T13549 17891-17895 Protein denotes RPS3
T13550 17944-17947 Protein denotes IL8
T13551 17949-17955 Protein denotes NFKBIA
T13552 17961-17968 Protein denotes TNFAIP3
T13553 18128-18134 Protein denotes ΔnleH1
T13554 18138-18143 Protein denotes ΔescN
T13555 18176-18184 Negative_regulation denotes deleting
T13556 18185-18190 Protein denotes nleH1
T13557 18260-18264 Protein denotes CD25
T13558 18269-18277 Protein denotes TNFSF13B
T13559 18343-18348 Protein denotes NleH1
T13560 18414-18422 Negative_regulation denotes blocking
T13561 18423-18427 Protein denotes RPS3
T13562 18428-18432 Entity denotes S209
T13563 18433-18448 Phosphorylation denotes phosphorylation
T13564 18480-18484 Protein denotes RPS3
T14274 18516-18521 Protein denotes NleH1
T14275 18522-18530 Negative_regulation denotes inhibits
T14276 18531-18535 Protein denotes RPS3
T14277 18536-18540 Entity denotes S209
T14278 18541-18556 Phosphorylation denotes phosphorylation
T14279 18665-18671 Protein denotes ΔnleH1
T14280 18771-18777 Protein denotes ΔnleH1
T14281 19007-19012 Protein denotes NleH1
T14282 19013-19020 Negative_regulation denotes blocked
T14283 19021-19025 Protein denotes RPS3
T14284 19026-19030 Entity denotes S209
T14285 19031-19046 Phosphorylation denotes phosphorylation
T14286 19064-19074 Negative_regulation denotes preventing true
T14287 19075-19079 Protein denotes RPS3
T14288 19080-19087 Entity denotes nuclear
T14289 19088-19101 Localization denotes translocation
T14290 19339-19342 Negative_regulation denotes low
T14291 19353-19360 Phosphorylation denotes phospho
T14292 19361-19365 Protein denotes RPS3
T14293 19409-19415 Protein denotes ΔnleH1
T14294 19424-19431 Phosphorylation denotes phospho
T14295 19432-19436 Protein denotes RPS3
T14296 19463-19470 Positive_regulation denotes intense
T14297 19510-19515 Protein denotes NleH1
T14298 19516-19524 Negative_regulation denotes inhibits
T14299 19525-19529 Protein denotes RPS3
T14300 19530-19534 Entity denotes S209
T14301 19535-19550 Phosphorylation denotes phosphorylation
T17472 19647-19652 Protein denotes NleH1
T17473 19664-19668 Protein denotes IKKβ
T17474 19693-19698 Protein denotes NleH1
T17475 19705-19723 Phosphorylation denotes autophosphorylated
T17476 19755-19762 Regulation denotes depends
T17477 19770-19780 Entity denotes lysine 159
T17478 19824-19829 Protein denotes NleH1
T17479 19830-19838 Negative_regulation denotes inhibits
T17480 19839-19843 Protein denotes RPS3
T17481 19844-19848 Entity denotes S209
T17482 19849-19864 Phosphorylation denotes phosphorylation
T17483 19934-19943 Protein denotes His-NleH1
T17484 19965-19974 Protein denotes His-NleH1
T17485 20008-20013 Protein denotes NleH1
T17486 20017-20035 Phosphorylation denotes autophosphorylated
T17487 20044-20049 Entity denotes K159A
T17488 20056-20061 Protein denotes NleH1
T17489 20062-20073 Negative_regulation denotes kinase-dead
T17490 20134-20142 Regulation denotes required true
T17491 20147-20152 Protein denotes NleH1
T17492 20156-20163 Negative_regulation denotes inhibit
T17493 20164-20168 Protein denotes IKKβ
T17494 20169-20184 Phosphorylation denotes phosphorlyation
T17495 20188-20192 Protein denotes RPS3
T17496 20196-20200 Entity denotes S209
T17497 20254-20259 Protein denotes NleH1
T17498 20285-20290 Protein denotes NleH1
T17499 20291-20301 Gene_expression denotes expression
T17500 20316-20323 Negative_regulation denotes reduced
T17501 20328-20335 Positive_regulation denotes induced
T17502 20336-20340 Protein denotes RPS3
T17503 20341-20345 Entity denotes S209
T17504 20346-20361 Phosphorylation denotes phosphorylation
T17505 20388-20394 Negative_regulation denotes failed
T17506 20420-20425 Protein denotes NleH1
T17507 20445-20453 Positive_regulation denotes required
T17508 20457-20464 Negative_regulation denotes protect
T17509 20465-20469 Protein denotes RPS3
T17510 20475-20479 Protein denotes IKKβ
T17511 20480-20488 Positive_regulation denotes mediated
T17512 20489-20504 Phosphorylation denotes phosphorylation
T17513 20648-20652 Protein denotes NleH
T17514 20653-20662 Negative_regulation denotes inhibited
T17515 20653-20662 Negative_regulation denotes inhibited
T17516 20663-20667 Protein denotes RPS3
T17517 20668-20675 Entity denotes nuclear
T17518 20676-20689 Localization denotes translocation
T17519 20694-20698 Protein denotes RPS3
T17520 20699-20708 Regulation denotes dependent
T17521 20715-20725 Protein denotes luciferase
T17522 20726-20734 Positive_regulation denotes activity
T17523 20770-20775 Protein denotes NleH1
T17524 20797-20801 Protein denotes RPS3
T17525 20802-20806 Entity denotes S209
T17526 20807-20822 Phosphorylation denotes phosphorylation
T17527 20941-20949 Positive_regulation denotes increase
T17528 20953-20957 Protein denotes RPS3
T17529 20958-20962 Entity denotes S209
T17530 20963-20978 Phosphorylation denotes phosphorylation
T17531 20995-21007 Positive_regulation denotes augmentation
T17532 21011-21015 Protein denotes RPS3
T17533 21016-21031 Phosphorylation denotes phosphorylation
T17534 21036-21043 Negative_regulation denotes reduced
T17535 21113-21117 Protein denotes RPS3
T17536 21118-21133 Phosphorylation denotes phosphorylation
T17537 21138-21146 Positive_regulation denotes enhanced
T17538 21199-21206 Negative_regulation denotes lacking
T17539 21207-21211 Protein denotes NleH
T17540 21222-21227 Protein denotes ΔnleH
T17541 21262-21267 Protein denotes NleH1
T17542 21307-21312 Protein denotes ΔnleH
T17543 21348-21355 Gene_expression denotes express
T17544 21390-21395 Protein denotes NleH1
T17545 21411-21416 Protein denotes ΔnleH
T17546 21439-21444 Protein denotes NleH1
T17547 21452-21461 Negative_regulation denotes abolished
T17548 21462-21465 Protein denotes TNF
T17549 21466-21473 Positive_regulation denotes induced
T17550 21474-21478 Protein denotes RPS3
T17551 21479-21483 Entity denotes S209
T17552 21484-21499 Phosphorylation denotes phosphorylation
T17553 21543-21550 Negative_regulation denotes inhibit true
T17554 21551-21555 Protein denotes RPS3
T17555 21556-21571 Phosphorylation denotes phosphorylation
T17556 21628-21633 Protein denotes NleH1
T17557 21653-21661 Positive_regulation denotes required
T17558 21665-21670 Negative_regulation denotes block
T17559 21671-21675 Protein denotes RPS3
T17560 21676-21680 Entity denotes S209
T17561 21681-21696 Phosphorylation denotes phosphorylation
T17562 21750-21755 Protein denotes NleH1
T17563 21782-21788 Negative_regulation denotes impair true
T17564 21800-21807 Entity denotes nuclear
T17565 21808-21821 Localization denotes translocation
T17566 21825-21829 Protein denotes RPS3
T17567 21830-21837 Positive_regulation denotes trigged
T17568 21845-21866 Positive_regulation denotes constitutively-active
T17569 21867-21871 Protein denotes IKKβ
T17570 21873-21877 Protein denotes IKKβ
T17571 21879-21883 Positive_regulation denotes SSEE
T17572 21954-21963 Protein denotes SSEE IKKβ
T17573 21974-21983 Positive_regulation denotes triggered
T17574 21989-21993 Protein denotes RPS3
T17575 21994-22001 Entity denotes nuclear
T17576 22002-22015 Localization denotes translocation
T17577 22025-22036 Negative_regulation denotes kinase-dead
T17578 22037-22041 Protein denotes IKKβ
T17579 22043-22047 Negative_regulation denotes SSAA
T17580 22068-22072 Protein denotes RPS3
T17581 22073-22080 Entity denotes nuclear
T17582 22081-22093 Localization denotes accumulation
T17583 22112-22120 Negative_regulation denotes retarded
T17584 22217-22223 Protein denotes ΔnleH1
T17585 22227-22232 Protein denotes ΔescN
T17586 22264-22268 Protein denotes RPS3
T17587 22269-22276 Entity denotes nuclear
T17588 22277-22290 Localization denotes translocation
T17589 22301-22305 Protein denotes IKKβ
T17590 22310-22314 Protein denotes IKKβ
T17591 22316-22320 Positive_regulation denotes SSEE
T17592 22322-22332 Gene_expression denotes expressing
T17593 22322-22332 Gene_expression denotes expressing
T17594 22390-22396 Regulation denotes affect true
T17595 22401-22405 Protein denotes RPS3
T17596 22406-22413 Entity denotes nuclear
T17597 22414-22427 Localization denotes translocation
T17598 22431-22435 Protein denotes IKKβ
T17599 22437-22441 Negative_regulation denotes SSAA
T17600 22443-22453 Gene_expression denotes expressing
T17601 22525-22530 Protein denotes NleH1
T17602 22557-22564 Negative_regulation denotes inhibit
T17603 22565-22569 Protein denotes RPS3
T17604 22570-22577 Entity denotes nuclear
T17605 22578-22591 Localization denotes translocation
T17606 22606-22616 Gene_expression denotes expressing
T17607 22632-22641 Positive_regulation denotes activated
T17608 22642-22646 Protein denotes IKKβ
T17609 22668-22673 Protein denotes NleH1
T17610 22689-22702 Phosphorylation denotes phosphorylate
T17611 22703-22707 Protein denotes IKKβ
T17612 22708-22712 Positive_regulation denotes thus true
T17613 22713-22723 Negative_regulation denotes inhibiting
T17614 22724-22728 Protein denotes IKKβ
T17615 22729-22737 Positive_regulation denotes mediated
T17616 22738-22742 Protein denotes RPS3
T17617 22743-22747 Entity denotes S209
T17618 22748-22763 Phosphorylation denotes phosphorylation
T17619 22826-22842 Protein denotes Flag-IKKβ (K44A)
T17620 22872-22881 Protein denotes His-NleH1
T17621 22901-22905 Protein denotes IKKβ
T17622 22906-22925 Phosphorylation denotes autophosphorylation
T17623 22944-22949 Protein denotes NleH1
T17624 22958-22973 Phosphorylation denotes phosphorylation
T17625 23018-23035 Phosphorylation denotes 32P incorporation true
T17626 23039-23043 Protein denotes IKKβ
T17627 23138-23143 Protein denotes NleH1
T17628 23160-23164 Protein denotes IKKβ
T17629 23277-23281 Protein denotes IKKβ
T17630 23296-23300 Protein denotes IKKβ
T17631 23301-23315 Phosphorylation denotes phosphorylated
T17632 23301-23315 Phosphorylation denotes phosphorylated
T17633 23316-23320 Protein denotes RPS3
T17634 23343-23351 Protein denotes GST-IκBα
T17635 23429-23450 Regulation denotes substrate specificity
T17636 23469-23473 Protein denotes IKKβ
T17637 23479-23484 Protein denotes NleH1
T17638 23485-23492 Negative_regulation denotes reduced true
T17639 23485-23492 Negative_regulation denotes reduced true
T17640 23493-23497 Protein denotes IKKβ
T17641 23498-23506 Positive_regulation denotes mediated
T17642 23507-23511 Protein denotes RPS3
T17643 23512-23527 Phosphorylation denotes phosphorylation
T17644 23570-23574 Protein denotes IKKβ
T17645 23575-23583 Positive_regulation denotes mediated
T17646 23584-23592 Protein denotes GST-IκBα
T17647 23593-23608 Phosphorylation denotes phosphorylation
T17648 23685-23690 Protein denotes NleH1
T17649 23691-23699 Positive_regulation denotes mediated true
T17650 23691-23699 Positive_regulation denotes mediated true
T17651 23691-23699 Positive_regulation denotes mediated true
T17652 23691-23699 Positive_regulation denotes mediated true
T17653 23700-23715 Phosphorylation denotes phosphorylation
T17654 23700-23715 Phosphorylation denotes phosphorylation
T17655 23719-23738 Phosphorylation denotes autophosphorylation
T17656 23719-23738 Phosphorylation denotes autophosphorylation
T17657 23742-23746 Protein denotes RPS3
T17658 23750-23758 Protein denotes GST-IκBα
T17659 23786-23791 Protein denotes NleH1
T17660 23832-23836 Protein denotes IKKβ
T17661 23842-23852 Negative_regulation denotes inhibiting
T17662 23857-23861 Protein denotes IKKβ
T17663 23862-23870 Positive_regulation denotes mediated
T17664 23871-23875 Protein denotes RPS3
T17665 23876-23880 Entity denotes S209
T17666 23881-23896 Phosphorylation denotes phosphorylation
T20021 24005-24009 Protein denotes RPS3
T20022 24174-24182 Positive_regulation denotes triggers true
T20023 24183-24187 Protein denotes RPS3
T20024 24191-24202 Localization denotes translocate
T20025 24244-24251 Entity denotes nucleus
T20026 24273-24277 Protein denotes IKKβ
T20027 24278-24286 Positive_regulation denotes mediated
T20028 24287-24291 Protein denotes RPS3
T20029 24292-24296 Entity denotes S209
T20030 24297-24312 Phosphorylation denotes phosphorylation
T20031 24326-24334 Regulation denotes critical
T20032 24364-24371 Entity denotes nuclear
T20033 24372-24378 Localization denotes import
T20034 24449-24453 Protein denotes IKKβ
T20035 24586-24590 Protein denotes RPS3
T20036 24716-24720 Protein denotes IKKβ
T20037 24815-24819 Protein denotes IKKβ
T20038 24829-24833 Protein denotes IKKα
T20039 24835-24849 Phosphorylation denotes phosphorylated
T20040 24835-24849 Phosphorylation denotes phosphorylated true
T20041 24850-24854 Protein denotes RPS3
T20042 24900-24910 Regulation denotes modulation
T20043 24900-24910 Regulation denotes modulation
T20044 24915-24919 Protein denotes RPS3
T20045 24920-24927 Entity denotes nuclear
T20046 24928-24941 Localization denotes translocation
T20047 24943-24946 Positive_regulation denotes via
T20048 25035-25048 Phosphorylation denotes phosphorylate
T20049 25049-25052 Protein denotes p65
T20050 25060-25064 Binding denotes bind
T20051 25072-25085 Phosphorylation denotes phosphorylate
T20052 25086-25090 Protein denotes IKKβ
T20053 25144-25148 Protein denotes IKKβ
T20054 25149-25154 Binding denotes bound
T20055 25165-25176 Positive_regulation denotes account for true
T20056 25190-25194 Protein denotes RPS3
T20057 25195-25210 Phosphorylation denotes phosphorylation
T20058 25246-25250 Protein denotes IKKβ
T20059 25308-25312 Protein denotes RPS3
T20060 25534-25538 Protein denotes RPS3
T20061 25687-25691 Protein denotes IKKβ
T20062 25692-25700 Positive_regulation denotes mediated
T20063 25701-25705 Protein denotes RPS3
T20064 25706-25710 Entity denotes S209
T20065 25711-25726 Phosphorylation denotes phosphorylation
T20066 25748-25757 Regulation denotes modulated
T20067 25831-25836 Protein denotes NleH1
T20068 25850-25855 Binding denotes binds
T20069 25859-25863 Protein denotes RPS3
T20070 25997-26002 Protein denotes NleH1
T20071 26015-26023 Negative_regulation denotes inhibits
T20072 26024-26028 Protein denotes RPS3
T20073 26029-26044 Phosphorylation denotes phosphorylation
T20074 26051-26060 Negative_regulation denotes retarding
T20075 26065-26072 Entity denotes nuclear
T20076 26073-26086 Localization denotes translocation
T20077 26167-26172 Protein denotes NleH1
T20078 26190-26203 Phosphorylation denotes phosphorylate true
T20079 26204-26208 Protein denotes IKKβ
T20080 26246-26253 Negative_regulation denotes inhibit
T20081 26254-26258 Protein denotes IKKβ
T20082 26259-26267 Positive_regulation denotes mediated
T20083 26268-26272 Protein denotes RPS3
T20084 26273-26277 Entity denotes S209
T20085 26278-26293 Phosphorylation denotes phosphorylation
T20086 26424-26429 Protein denotes NleH1
T20087 26433-26438 Regulation denotes steer
T20088 26468-26472 Protein denotes IKKβ
T20089 26739-26744 Protein denotes NleH1
T20090 26777-26781 Protein denotes RPS3
T20091 26911-26914 Protein denotes IL8
T20092 26937-26942 Protein denotes NleH1
T20093 26952-26957 Negative_regulation denotes block true
T20094 26964-26967 Protein denotes p65
T20095 26968-26975 Entity denotes nuclear
T20096 26976-26989 Localization denotes translocation
T20097 27019-27022 Protein denotes p65
T20098 27037-27041 Protein denotes RPS3
T20099 27175-27185 Negative_regulation denotes inhibiting
T20100 27186-27190 Protein denotes RPS3
T20101 27229-27234 Protein denotes NleH1
T20102 27821-27829 Negative_regulation denotes impeding
T20103 27830-27834 Protein denotes RPS3
T20104 27844-27852 Regulation denotes altering
T20105 27853-27856 Protein denotes p65
T20106 27857-27864 Entity denotes nuclear
T20107 27865-27878 Localization denotes translocation
T20108 28108-28115 Regulation denotes effects
T20109 28136-28140 Protein denotes RPS3
T20821 29321-29337 Protein denotes Flag-IKKβ (SSEE)
T20822 29339-29355 Protein denotes Flag-IKKβ (SSAA)
T20823 29361-29375 Protein denotes HA-IκBα (SSAA)
T20824 29481-29488 Protein denotes HA-IκBα
T20825 29493-29509 Protein denotes IKKβ (K44A)-Flag
T20826 29558-29567 Protein denotes Flag-RPS3
T20827 29569-29577 Protein denotes GST-RPS3
T20828 29579-29586 Protein denotes HA-RPS3
T20829 29588-29593 Protein denotes VN-HA
T20830 29595-29603 Protein denotes NleH1-HA
T20831 29665-29669 Protein denotes RPS3
T21349 30296-30300 Protein denotes IKKβ
T21350 30305-30309 Protein denotes IKKα
T21351 30470-30478 Protein denotes GST-RPS3
T21352 30483-30487 Protein denotes RPS3
T21532 31009-31017 Protein denotes GST-RPS3
T21533 31049-31053 Protein denotes IKKβ
T21698 31486-31490 Protein denotes IKKα
T21699 31526-31530 Protein denotes IKKβ
T21700 31566-31570 Protein denotes IκBα
T21701 31606-31610 Protein denotes RPS3
T22201 32705-32715 Protein denotes luciferase
T22202 32742-32752 Protein denotes luciferase
T22318 33114-33117 Protein denotes IL8
T22319 33122-33128 Protein denotes NFKBIA
T22320 33141-33145 Protein denotes ACTB
T23092 34908-34915 Protein denotes albumin
T23187 35151-35155 Protein denotes IL-8
T23188 35242-35255 Protein denotes Interleukin-8
T23189 35275-35278 Protein denotes kit
T4689 6438-6448 Localization denotes detectable
T11318 12254-12258 Protein denotes RPS3
R439 T562 T563 themeOf IKKβ,phosphorylation
R440 T563 T564 causeOf phosphorylation,regulates
R441 T565 T567 themeOf RPS3,translocation
R442 T566 T567 locationOf nuclear,translocation
R443 T567 T564 themeOf translocation,regulates
R444 T569 T568 equivalentTo RPS3,ribosomal protein S3
R445 T570 T572 themeOf RPS3,translocation
R446 T571 T572 locationOf nuclear,translocation
R447 T572 T573 themeOf translocation,regulated
R448 T575 T577 causeOf phosphorylation,crucial
R449 T576 T575 themeOf serine 209,phosphorylation
R450 T576 T574 partOf serine 209,IKKβ
R451 T578 T580 themeOf RPS3,localization
R452 T578 T582 themeOf RPS3,activating
R453 T579 T580 locationOf nuclear,localization
R454 T580 T581 themeOf localization,in response to
R455 T581 T577 themeOf in response to,crucial
R456 T582 T581 causeOf activating,in response to
R457 T583 T584 causeOf NleH1,inhibited
R458 T584 T588 causeOf inhibited,blocked
R459 T586 T587 themeOf S209,phosphorylation
R460 T586 T585 partOf S209,RPS3
R461 T587 T584 themeOf phosphorylation,inhibited
R462 T589 T588 themeOf RPS3,blocked
R463 T590 T591 causeOf IKKβ,dependent
R464 T592 T591 themeOf modification,dependent
R465 T593 T592 themeOf RPS3,modification
R1464 T1835 T1834 equivalentTo p65,RelA
R1468 T1841 T1840 equivalentTo RPS3,ribosomal protein S3
R1473 T1845 T1846 themeOf immunoglobulin κ light chain,expression
R1475 T1847 T1852 causeOf NleH1,affecting
R1476 T1847 T1848 causeOf NleH1,attenuating
R1478 T1849 T1851 themeOf RPS3,translocation
R1480 T1850 T1851 locationOf nuclear,translocation
R1481 T1851 T1848 themeOf translocation,attenuating
R1482 T1853 T1854 themeOf p65,localization
R1483 T1854 T1852 themeOf localization,affecting
R1485 T1861 T1862 themeOf RPS3,phosphorylated
R1486 T1856 T1858 themeOf RPS3,translocation
R1487 T1863 T1864 themeOf RPS3,phosphorylated
R1488 T1857 T1858 locationOf nuclear,translocation
R1489 T1858 T1855 themeOf translocation,induce
R1490 T1860 T1859 themeOf RPS3,binding
R1491 T1866 T1868 causeOf Inhibitor of κB (IκB) kinase beta,phosphorylated
R1492 T1867 T1866 equivalentTo IKKβ,Inhibitor of κB (IκB) kinase beta
R1493 T1877 T1879 themeOf RPS3,translocation
R1494 T1878 T1879 locationOf nuclear,translocation
R1495 T1879 T1876 themeOf translocation,mediating
R1496 T1880 T1881 causeOf NleH1,inhibited
R1497 T1870 T1868 themeOf serine 209,phosphorylated
R1498 T1883 T1881 themeOf S209,inhibited
R1499 T1883 T1882 partOf S209,RPS3
R1500 T1870 T1869 partOf serine 209,RPS3
R1501 T1871 T1875 themeOf RPS3,association
R1502 T1872 T1873 themeOf S209,phosphorylation
R1503 T1872 T1871 partOf S209,RPS3
R1504 T1873 T1874 causeOf phosphorylation,enhanced
R1505 T1874 T1876 causeOf enhanced,mediating
R1506 T1875 T1874 themeOf association,enhanced
R1965 T2479 T2480 themeOf RPS3,phosphorylation
R1966 T2480 T2481 themeOf phosphorylation,in response to
R1967 T2482 T2483 themeOf RPS3,phosphorylated
R1968 T2484 T2485 themeOf RPS3,phosphorylated
R1969 T2487 T2486 themeOf 32P-incorporation,increase
R1970 T2489 T2487 themeOf RPS3,32P-incorporation
R1971 T2489 T2488 themeOf RPS3,increase
R1972 T2491 T2492 themeOf residues,phosphorylated
R1973 T2491 T2490 partOf residues,RPS3
R1974 T2496 T2495 themeOf phosphorylation,stimulated
R1975 T2497 T2494 themeOf degradaion,stimulated
R1976 T2498 T2496 themeOf IκBα,phosphorylation
R1977 T2498 T2497 themeOf IκBα,degradaion
R1978 T2501 T2500 themeOf serine residues,phosphorylation
R1979 T2501 T2499 partOf serine residues,RPS3
R1980 T2502 T2505 themeOf tyrosine,phosphorylation
R1981 T2502 T2506 partOf tyrosine,RPS3
R1982 T2503 T2504 themeOf threonine,phosphorylation
R1983 T2503 T2506 partOf threonine,RPS3
R2507 T3194 T3196 themeOf RPS3,interaction
R2508 T3195 T3196 themeOf IKKβ,interaction
R2509 T3205 T3204 themeOf IKKβ,activated
R2510 T3205 T3206 themeOf IKKβ,bind
R2511 T3208 T3206 themeOf RPS3,bind
R2512 T3208 T3207 themeOf RPS3,phosphorylate
R2513 T3210 T3209 themeOf IKKβ,expressed
R2514 T3210 T3212 themeOf IKKβ,interacted
R2515 T3211 T3212 themeOf RPS3,interacted
R2516 T3213 T3215 themeOf IKKβ,interaction
R2517 T3214 T3215 themeOf RPS3,interaction
R2518 T3216 T3218 themeOf RPS3,association
R2519 T3217 T3218 themeOf IKKβ,association
R2520 T3218 T3219 themeOf association,augmented
R2521 T3219 T3220 causeOf augmented,following
R2522 T3222 T3223 themeOf serine,phosphorylation
R2523 T3222 T3221 partOf serine,RPS3
R2524 T3223 T3220 themeOf phosphorylation,following
R2525 T3225 T3224 themeOf RPS3,interaction
R2526 T3226 T3224 themeOf IKKα,interaction
R3610 T4610 T4611 causeOf IKKβ,required
R3612 T4612 T4614 themeOf RPS3,translocation
R3615 T4613 T4614 locationOf nuclear,translocation
R3619 T4614 T4611 themeOf translocation,required
R3625 T4615 T4617 themeOf RPS3,interaction
R3629 T4616 T4617 themeOf IKKβ,interaction
R3632 T4617 T4618 causeOf interaction,required
R3636 T4619 T4621 themeOf RPS3,translocation
R3640 T4620 T4621 locationOf nuclear,translocation
R3642 T4621 T4618 themeOf translocation,required
R3647 T4624 T4626 themeOf IKKα,expression
R3654 T4625 T4627 themeOf IKKβ,expression
R3656 T4626 T4622 themeOf expression,knocked down
R3658 T4627 T4623 themeOf expression,knocked down
R3662 T4629 T4631 themeOf RPS3,migration
R3667 T4630 T4631 locationOf nuclear,migration
R3671 T4631 T4628 themeOf migration,induced
R3677 T4633 T4635 themeOf RPS3,translocation
R3682 T4634 T4635 locationOf nuclear,translocation
R3686 T4635 T4632 themeOf translocation,triggered
R3689 T4636 T4638 themeOf RPS3,translocation
R3693 T4637 T4638 locationOf nuclear,translocation
R3696 T4638 T4639 themeOf translocation,impaired
R3699 T4640 T4641 themeOf IKKα,silencing
R3700 T4641 T4639 causeOf silencing,impaired
R3701 T4642 T4644 causeOf knockdown,attenuated
R3702 T4643 T4642 themeOf IKKβ,knockdown
R3703 T4645 T4647 themeOf RPS3,accumulation
R3704 T4682 T4680 causeOf SSAA,in
R3705 T4646 T4647 locationOf nuclear,accumulation
R3706 T4683 T4684 themeOf RPS3,translocated
R3707 T4684 T4686 themeOf translocated,in
R3708 T4685 T4684 locationOf nucleus,translocated
R3709 T4647 T4648 themeOf accumulation,following
R3710 T4687 T4688 themeOf IKKβ,SSEE
R3711 T4688 T4686 causeOf SSEE,in
R3712 T4648 T4644 themeOf following,attenuated
R3713 T4649 T4654 causeOf expression,necessary
R3714 T4650 T4653 causeOf expression,necessary
R3715 T4689 T4693 themeOf detectable,increased
R3716 T4651 T4649 themeOf IKKβ,expression
R3717 T4689 T4692 themeOf detectable,increased
R3718 T4652 T4650 themeOf IKKα,expression
R3719 T4690 T4689 locationOf nuclear,detectable
R3720 T4691 T4689 themeOf RPS3,detectable
R3721 T4655 T4654 themeOf induced,necessary
R3722 T4694 T4695 themeOf IKKβ,SSEE
R3723 T4695 T4693 causeOf SSEE,increased
R3724 T4696 T4697 themeOf IKKβ,SSAA
R3725 T4697 T4692 causeOf SSAA,increased
R3726 T4655 T4653 themeOf induced,necessary
R3727 T4656 T4658 themeOf RPS3,translocation
R3728 T4657 T4658 locationOf nuclear,translocation
R3729 T4698 T4699 causeOf IKKβ,necessary
R3730 T4658 T4655 themeOf translocation,induced
R3731 T4659 T4661 themeOf p65,translocation
R3732 T4660 T4661 locationOf nuclear,translocation
R3733 T4700 T4702 themeOf RPS3,translocation
R3734 T4701 T4702 locationOf nuclear,translocation
R3735 T4661 T4662 themeOf translocation,blocked
R3736 T4702 T4703 themeOf translocation,in response to
R3737 T4703 T4699 themeOf in response to,necessary
R3738 T4663 T4664 locationOf nuclear,translocation
R3739 T4665 T4664 themeOf RPS3,translocation
R3740 T4669 T4666 themeOf IKKβ,expressing
R3741 T4669 T4667 themeOf IKKβ,kinase-dead
R3742 T4669 T4668 themeOf IKKβ,constitutively-active
R3743 T4670 T4674 causeOf SSEE,induced
R3745 T4671 T4673 causeOf SSAA,induced
R3746 T4672 T4670 themeOf IKKβ,SSEE
R3750 T4672 T4671 themeOf IKKβ,SSAA
R3753 T4675 T4674 themeOf dependent,induced
R3755 T4675 T4673 themeOf dependent,induced
R3756 T4676 T4675 themeOf luciferase,dependent
R3758 T4677 T4678 themeOf RPS3,remained
R3761 T4678 T4680 themeOf remained,in
R3763 T4679 T4678 locationOf cytosolic,remained
R3767 T4681 T4682 themeOf IKKβ,SSAA
R5232 T6649 T6650 themeOf IκBα,degradation
R5239 T6651 T6653 themeOf RPS3,translocation
R5243 T6652 T6653 locationOf nuclear,translocation
R5246 T6655 T6656 locationOf nuclear,import
R5250 T6656 T6654 themeOf import,regulates
R5255 T6657 T6656 themeOf Rel,import
R5260 T6658 T6660 themeOf RPS3,translocation
R5265 T6659 T6660 locationOf nuclear,translocation
R5269 T6661 T6662 themeOf p65,translocation
R5270 T6665 T6666 themeOf RPS3,binding
R5272 T6665 T6669 themeOf RPS3,translocation
R5274 T6666 T6667 causeOf binding,essential
R5277 T6668 T6669 locationOf nuclear,translocation
R5279 T6669 T6667 themeOf translocation,essential
R5282 T6670 T6671 themeOf IκBα,degradation
R5285 T6671 T6672 causeOf degradation,prerequisite
R5288 T6673 T6672 themeOf unmask,prerequisite
R5292 T6674 T6673 themeOf NLS,unmask
R5295 T6674 T6675 partOf NLS,p65
R5297 T6676 T6678 themeOf RPS3,bind
R5302 T6677 T6679 themeOf IκBα,bind
R5304 T6680 T6678 themeOf p65,bind
R5311 T6680 T6679 themeOf p65,bind
R5312 T6681 T6682 themeOf IκBα,degradation
R5319 T6682 T6683 causeOf degradation,required
R5320 T6684 T6683 themeOf liberation,required
R5325 T6685 T6684 themeOf RPS3,liberation
R5328 T6687 T6686 themeOf RPS3,association
R5330 T6689 T6690 themeOf IκBα,SSAA
R5331 T6689 T6696 themeOf IκBα,phosphorylation
R5332 T6689 T6697 themeOf IκBα,degradation
R5333 T6690 T6692 causeOf SSAA,resistant
R5334 T6690 T6691 causeOf SSAA,resistant
R5335 T6737 T6736 themeOf RPS3,accumulation
R5336 T6693 T6695 causeOf IKKβ,induced
R5337 T6738 T6739 themeOf IκBα,degradation
R5338 T6693 T6694 causeOf IKKβ,induced
R5339 T6742 T6741 themeOf association,promotes
R5340 T6694 T6691 themeOf induced,resistant
R5341 T6743 T6744 locationOf nuclear,transport
R5342 T6744 T6740 themeOf transport,promotes
R5343 T6695 T6692 themeOf induced,resistant
R5344 T6745 T6742 themeOf RPS3,association
R5345 T6745 T6744 themeOf RPS3,transport
R5346 T6746 T6747 themeOf IκBα,degradation
R5347 T6696 T6695 themeOf phosphorylation,induced
R5348 T6749 T6750 themeOf RPS3,association
R5349 T6697 T6694 themeOf degradation,induced
R5350 T6750 T6748 themeOf association,required
R5351 T6751 T6752 themeOf IκBα,phosphorylation
R5352 T6751 T6753 themeOf IκBα,degradation
R5353 T6752 T6755 causeOf phosphorylation,cause
R5354 T6753 T6754 causeOf degradation,cause
R5355 T6700 T6699 themeOf interaction,augmented
R5356 T6756 T6757 themeOf RPS3,association
R5357 T6756 T6760 themeOf RPS3,translocation
R5358 T6757 T6758 causeOf association,followed
R5359 T6758 T6755 themeOf followed,cause
R5360 T6758 T6754 themeOf followed,cause
R5361 T6701 T6700 themeOf RPS3,interaction
R5362 T6759 T6760 locationOf nuclear,translocation
R5363 T6760 T6758 themeOf translocation,followed
R5364 T6702 T6703 themeOf RPS3,association
R5365 T6763 T6762 themeOf RPS3,phosphorylation
R5366 T6703 T6704 themeOf association,abolished
R5367 T6705 T6704 causeOf degradable,abolished
R5368 T6706 T6705 themeOf IκBα,degradable
R5369 T6707 T6708 causeOf IκBα,precluding
R5370 T6709 T6711 themeOf RPS3,translocation
R5372 T6710 T6711 locationOf nuclear,translocation
R5375 T6711 T6708 themeOf translocation,precluding
R5376 T6712 T6713 themeOf RPS3,association
R5380 T6716 T6717 themeOf IκBα,expression
R5383 T6717 T6715 themeOf expression,reducing
R5385 T6718 T6720 causeOf siRNA,depleted
R5388 T6720 T6724 causeOf depleted,augmented
R5392 T6721 T6720 themeOf IκBα,depleted
R5395 T6722 T6723 themeOf RPS3,association
R5399 T6723 T6724 themeOf association,augmented
R5402 T6725 T6727 locationOf nuclear,detected
R5406 T6726 T6727 themeOf RPS3,detected
R5409 T6728 T6731 causeOf induce,increased
R5412 T6728 T6732 causeOf induce,increased
R5416 T6729 T6730 themeOf IκBα,degradation
R5417 T6730 T6728 themeOf degradation,induce
R5420 T6733 T6731 themeOf association,increased
R5423 T6734 T6733 themeOf RPS3,association
R5425 T6735 T6736 locationOf nuclear,accumulation
R5427 T6736 T6732 themeOf accumulation,increased
R6820 T8531 T8532 causeOf IKKβ,phosphorylates
R6821 T8534 T8532 themeOf serine 209,phosphorylates
R6822 T8534 T8533 partOf serine 209,RPS3
R6823 T8535 T8537 causeOf IKKβ,phosphorylates
R6824 T8535 T8536 causeOf IKKβ,phosphorylates
R6825 T8538 T8537 themeOf 14-3-3β,phosphorylates
R6826 T8539 T8536 themeOf Bcl10,phosphorylates
R6827 T8540 T8541 causeOf IKKβ,phosphorylate
R6828 T8542 T8541 themeOf RPS3,phosphorylate
R6829 T8548 T8544 themeOf IKKα,incorporation of 32P
R6830 T8548 T8547 themeOf IKKα,autophosphorylatd
R6831 T8549 T8545 themeOf IKKβ,incorporation of 32P
R6832 T8549 T8546 themeOf IKKβ,autophosphorylatd
R6833 T8552 T8550 themeOf GST-IκBα,phosporylated
R6834 T8553 T8551 themeOf GST,phosporylated
R6835 T8556 T8558 themeOf GST-RPS3,phosphorylated
R6836 T8556 T8557 themeOf GST-RPS3,phosphorylated
R6837 T8559 T8558 causeOf IKKβ,phosphorylated
R6838 T8560 T8557 causeOf IKKα,phosphorylated
R6839 T8562 T8563 themeOf amino acid residue(s),phosphorylated
R6840 T8562 T8561 partOf amino acid residue(s),RPS3
R6841 T8564 T8563 causeOf IKKβ,phosphorylated
R6842 T8566 T8565 themeOf RPS3,phosphorylated
R6843 T8567 T8568 causeOf IKKβ,phosphorylated
R6844 T8569 T8568 themeOf S209,phosphorylated
R6845 T8569 T8570 partOf S209,RPS3
R6846 T8574 T8575 themeOf S209A,mutant
R6847 T8574 T8576 partOf S209A,RPS3
R6848 T8577 T8578 themeOf S209A,mutation
R6849 T8577 T8582 partOf S209A,RPS3
R6850 T8578 T8579 causeOf mutation,reduced
R6851 T8580 T8581 causeOf IKKβ–,mediated
R6852 T8581 T8579 themeOf mediated,reduced
R6853 T8582 T8583 themeOf RPS3,phosphorylation
R6854 T8583 T8581 themeOf phosphorylation,mediated
R6855 T8585 T8584 themeOf RPS3,phosphorylated
R6856 T8587 T8588 themeOf sequence motif,recognized
R6857 T8587 T8586 partOf sequence motif,RPS3
R6858 T8591 T8592 themeOf S209,phosphorylation
R6859 T8591 T8590 partOf S209,RPS3
R6860 T8592 T8593 themeOf phosphorylation,due
R6861 T8594 T8593 causeOf IKKβ,due
R6862 T8595 T8596 causeOf S209,critical
R6863 T8595 T8599 partOf S209,RPS3
R6864 T8597 T8598 causeOf IKKβ,phosphorylates
R6865 T8598 T8596 themeOf phosphorylates,critical
R6866 T8599 T8598 themeOf RPS3,phosphorylates
R6867 T8602 T8600 themeOf Flag-RPS3,transfected
R6868 T8603 T8601 themeOf IKKβ,transfected
R6869 T8604 T8606 causeOf overexpressing,enhanced
R6870 T8605 T8604 themeOf IKKβ,overexpressing
R6871 T8607 T8608 themeOf Flag-RPS3,phosphorylation
R6872 T8608 T8606 themeOf phosphorylation,enhanced
R6873 T8608 T8609 themeOf phosphorylation,eliminated
R6874 T8610 T8609 causeOf alanine substitution,eliminated
R6875 T8611 T8610 themeOf S209,alanine substitution
R6876 T8611 T8607 partOf S209,Flag-RPS3
R6877 T8611 T8613 themeOf S209,phosphorylation
R6878 T8616 T8618 themeOf phosphorylated,dependent
R6879 T8617 T8616 themeOf S209,phosphorylated
R6880 T8617 T8615 partOf S209,RPS3
R6881 T8618 T8619 themeOf dependent,upon
R9099 T11312 T11311 themeOf RPS3,Phosphorylation
R9100 T11317 T11315 themeOf translocation,plays a role
R9101 T11313 T11314 themeOf S209,phosphorylation
R9102 T11313 T11318 partOf S209,RPS3
R9103 T11318 T11317 themeOf RPS3,translocation
R9104 T11319 T11320 themeOf S209A,mutant
R9105 T11314 T11315 causeOf phosphorylation,plays a role
R9106 T11319 T11321 partOf S209A,RPS3
R9107 T11323 T11325 themeOf Flag-RPS3,translocation
R9108 T11316 T11317 locationOf nuclear,translocation
R9109 T11324 T11325 locationOf nuclear,translocation
R9110 T11325 T11322 themeOf translocation,triggered
R9111 T11326 T11329 themeOf RPS3,translocation
R9112 T11413 T11415 themeOf p65,translocation
R9113 T11414 T11415 locationOf nuclear,translocation
R9114 T11327 T11330 causeOf S209A,attenuated
R9115 T11415 T11412 themeOf translocation,impact
R9116 T11417 T11418 themeOf p65,recruitment
R9117 T11327 T11326 partOf S209A,RPS3
R9118 T11418 T11416 themeOf recruitment,attenuated
R9119 T11328 T11329 locationOf nuclear,translocation
R9120 T11419 T11420 themeOf p65,attraction
R9121 T11329 T11330 themeOf translocation,attenuated
R9122 T11420 T11431 themeOf attraction,specific
R9123 T11420 T11424 themeOf attraction,increased
R9124 T11333 T11332 themeOf IKKβ,overexpressing
R9125 T11422 T11420 locationOf promoters,attraction
R9126 T11425 T11427 themeOf Flag-RPS3,recruitment
R9127 T11334 T11336 themeOf RPS3,translocation
R9128 T11426 T11428 themeOf p65,recruitment
R9129 T11335 T11336 locationOf nuclear,translocation
R9130 T11430 T11428 locationOf promoter,recruitment
R9131 T11430 T11427 locationOf promoter,recruitment
R9132 T11432 T11437 themeOf recruitment,depended
R9133 T11336 T11331 themeOf translocation,impact
R9134 T11340 T11341 locationOf nuclear,translocation
R9135 T11433 T11432 themeOf RPS3,recruitment
R9136 T11434 T11438 themeOf recruitment,depended
R9137 T11435 T11434 themeOf p65,recruitment
R9138 T11436 T11432 locationOf promoters,recruitment
R9139 T11436 T11434 locationOf promoters,recruitment
R9140 T11341 T11339 themeOf translocation,induced
R9141 T11439 T11437 causeOf S209,depended
R9142 T11439 T11433 partOf S209,RPS3
R9143 T11439 T11438 causeOf S209,depended
R9144 T11440 T11442 themeOf Interleukin 8,secretion
R9145 T11440 T11444 themeOf Interleukin 8,stimulation
R9146 T11342 T11341 themeOf RPS3,translocation
R9147 T11343 T11344 themeOf S209,phosphorylation
R9148 T11441 T11440 equivalentTo IL-8,Interleukin 8
R9149 T11442 T11443 themeOf secretion,induced
R9150 T11443 T11445 themeOf induced,decreased
R9151 T11343 T11347 partOf S209,RPS3
R9152 T11444 T11443 causeOf stimulation,induced
R9153 T11344 T11345 causeOf phosphorylation,critical
R9154 T11446 T11445 causeOf reduced,decreased
R9155 T11346 T11345 themeOf induced,critical
R9156 T11447 T11449 themeOf RPS3,recruitment
R9157 T11449 T11446 themeOf recruitment,reduced
R9158 T11347 T11349 themeOf RPS3,translocation
R9159 T11451 T11449 themeOf κB sites,recruitment
R9160 T11451 T11450 partOf κB sites,IL8
R9161 T11452 T11446 causeOf S209A,reduced
R9162 T11452 T11453 partOf S209A,RPS3
R9163 T11348 T11349 locationOf nuclear,translocation
R9164 T11454 T11455 themeOf CD25,expression
R9165 T11349 T11346 themeOf translocation,induced
R9166 T11456 T11457 themeOf RPS3,transfected
R9167 T11350 T11351 themeOf S209,phosphorylation
R9168 T11459 T11460 themeOf S209,phosphorylation
R9169 T11459 T11458 partOf S209,RPS3
R9170 T11460 T11461 themeOf phosphorylation,by
R9171 T11350 T11352 partOf S209,RPS3
R9172 T11354 T11355 themeOf RPS3,expression
R9173 T11462 T11461 causeOf IKKβ,by
R9174 T11355 T11353 themeOf expression,silenced
R9175 T11357 T11358 themeOf RPS3,transfection
R9176 T11359 T11360 causeOf RPS3 siRNA,reduced
R9177 T11359 T11362 causeOf RPS3 siRNA,affect
R9178 T11361 T11360 themeOf RPS3,reduced
R9179 T11363 T11362 themeOf expression,affect
R9180 T11364 T11363 themeOf Flag-tagged RPS3,expression
R9181 T11365 T11366 themeOf RPS3,knockdown
R9183 T11366 T11367 causeOf knockdown,reduced
R9185 T11368 T11367 themeOf induced,reduced
R9187 T11369 T11368 themeOf expression,induced
R9191 T11371 T11369 themeOf luciferase,expression
R9195 T11371 T11370 themeOf luciferase,driven
R9196 T11372 T11374 themeOf impaired,caused
R9199 T11373 T11372 themeOf luciferase,impaired
R9204 T11375 T11376 themeOf RPS3,deficiency
R9207 T11376 T11374 causeOf deficiency,caused
R9208 T11378 T11377 themeOf RPS3,transfecting
R9213 T11380 T11379 themeOf green fluorescent protein,overexpression
R9215 T11381 T11380 equivalentTo GFP,green fluorescent protein
R9220 T11384 T11385 themeOf S209,phosphorylation
R9225 T11384 T11383 partOf S209,RPS3
R9227 T11386 T11387 themeOf S209,phosphorylation
R9228 T11386 T11390 partOf S209,RPS3
R9229 T11387 T11388 causeOf phosphorylation,affects
R9232 T11387 T11389 causeOf phosphorylation,affects
R9233 T11390 T11392 themeOf RPS3,recruitment
R9236 T11391 T11393 themeOf p65,recruitment
R9238 T11392 T11388 themeOf recruitment,affects
R9244 T11393 T11389 themeOf recruitment,affects
R9247 T11394 T11395 themeOf RPS3,knockdown
R9250 T11400 T11398 themeOf recruitment,stimulated
R9258 T11401 T11399 themeOf recruitment,stimulated
R9261 T11402 T11396 themeOf recruitment,stimulated
R9262 T11403 T11397 themeOf recruitment,stimulated
R9269 T11405 T11403 themeOf S209A,recruitment
R9273 T11405 T11406 partOf S209A,RPS3
R9275 T11405 T11400 themeOf S209A,recruitment
R9276 T11406 T11402 themeOf RPS3,recruitment
R9277 T11406 T11401 themeOf RPS3,recruitment
R9278 T11406 T11404 themeOf RPS3,expressed
R9279 T11407 T11403 themeOf κB sites,recruitment
R9281 T11407 T11408 partOf κB sites,NFKBIA
R9282 T11407 T11402 themeOf κB sites,recruitment
R9283 T11407 T11400 themeOf κB sites,recruitment
R9284 T11407 T11409 partOf κB sites,IL8
R9285 T11407 T11401 themeOf κB sites,recruitment
R9287 T11411 T11412 causeOf S209A,impact
R9306 T11411 T11410 partOf S209A,RPS3
R9308 T11411 T11416 causeOf S209A,attenuated
R10816 T13458 T13459 causeOf NleH1,inhibits
R10817 T13460 T13461 themeOf RPS3,phosphorylation
R10818 T13461 T13459 themeOf phosphorylation,inhibits
R10819 T13462 T13463 themeOf NleH1,binds
R10820 T13463 T13464 causeOf binds,attenuates
R10821 T13465 T13467 themeOf RPS3,translocation
R10822 T13465 T13463 themeOf RPS3,binds
R10823 T13466 T13467 locationOf nuclear,translocation
R10824 T13467 T13464 themeOf translocation,attenuates
R10825 T13469 T13470 causeOf NleH1,inhibiting
R10826 T13472 T13473 themeOf S209,phosphorylation
R10827 T13472 T13471 partOf S209,RPS3
R10828 T13473 T13470 themeOf phosphorylation,inhibiting
R10829 T13475 T13474 themeOf NleH1-HA,increasing
R10830 T13477 T13479 causeOf NleH1,reduced
R10831 T13477 T13478 causeOf NleH1,reduced
R10832 T13480 T13481 causeOf TNF,induced
R10833 T13481 T13479 themeOf induced,reduced
R10834 T13482 T13483 themeOf RPS3,phosphorylation
R10835 T13483 T13481 themeOf phosphorylation,induced
R10836 T13483 T13478 themeOf phosphorylation,reduced
R10837 T13484 T13487 causeOf Expressing,interfere
R10838 T13484 T13489 themeOf Expressing,activation
R10839 T13484 T13486 causeOf Expressing,interfere
R10840 T13485 T13484 themeOf NleH1,Expressing
R10841 T13488 T13489 causeOf TNF,activation
R10842 T13489 T13487 themeOf activation,interfere
R10843 T13490 T13491 themeOf IκBα,degradation
R10844 T13491 T13486 themeOf degradation,interfere
R10845 T13492 T13494 causeOf lack,impact
R10846 T13493 T13492 themeOf NleH1,lack
R10847 T13495 T13497 themeOf p65,translocation
R10848 T13496 T13497 locationOf nuclear,translocation
R10849 T13497 T13494 themeOf translocation,impact
R10850 T13498 T13499 causeOf NleH1,inhibits
R10851 T13500 T13501 themeOf RPS3,phosphorylation
R10852 T13501 T13499 themeOf phosphorylation,inhibits
R10853 T13503 T13502 themeOf nleH1,lacking
R10854 T13507 T13508 causeOf TNF,increase
R10855 T13510 T13511 themeOf S209,phosphorylation
R10856 T13510 T13509 partOf S209,RPS3
R10857 T13511 T13508 themeOf phosphorylation,increase
R10858 T13513 T13514 themeOf S209,phosphorylation
R10859 T13513 T13512 partOf S209,RPS3
R10860 T13514 T13515 themeOf phosphorylation,impaired
R10861 T13516 T13517 causeOf TNF,induced
R10862 T13517 T13521 themeOf induced,unimpaired
R10863 T13517 T13522 themeOf induced,unimpaired
R10864 T13519 T13520 themeOf S209,phosphorylation
R10865 T13519 T13518 partOf S209,RPS3
R10866 T13520 T13517 themeOf phosphorylation,induced
R10867 T13523 T13521 causeOf ΔnleH1,unimpaired
R10868 T13524 T13522 causeOf ΔescN,unimpaired
R10869 T13525 T13527 causeOf ΔnleH1,attenuated
R10870 T13526 T13528 causeOf ΔescN,attenuated
R10871 T13529 T13530 causeOf TNF,induced
R10872 T13530 T13527 themeOf induced,attenuated
R10873 T13530 T13528 themeOf induced,attenuated
R10874 T13531 T13533 themeOf RPS3,translocation
R10875 T13532 T13533 locationOf nuclear,translocation
R10876 T13533 T13530 themeOf translocation,induced
R10877 T13534 T13535 themeOf RPS3,phosphorylation
R10878 T13534 T13537 themeOf RPS3,translocation
R10879 T13536 T13537 locationOf nuclear,translocation
R10880 T13538 T13543 themeOf RPS3,translocation
R10881 T13539 T13540 themeOf S209,phosphorylation
R10882 T13539 T13538 partOf S209,RPS3
R10883 T13540 T13541 causeOf phosphorylation,important
R10884 T13542 T13543 locationOf nuclear,translocation
R10885 T13543 T13541 themeOf translocation,important
R10886 T13544 T13545 causeOf NleH1,inhibits
R10887 T13547 T13548 themeOf S209,phosphorylation
R10888 T13547 T13546 partOf S209,RPS3
R10889 T13548 T13545 themeOf phosphorylation,inhibits
R10890 T13556 T13555 themeOf nleH1,deleting
R10891 T13559 T13560 causeOf NleH1,blocking
R10892 T13562 T13563 themeOf S209,phosphorylation
R10893 T13562 T13561 partOf S209,RPS3
R10894 T13563 T13560 themeOf phosphorylation,blocking
R11478 T14274 T14275 causeOf NleH1,inhibits
R11479 T14277 T14278 themeOf S209,phosphorylation
R11480 T14277 T14276 partOf S209,RPS3
R11481 T14278 T14275 themeOf phosphorylation,inhibits
R11482 T14281 T14282 causeOf NleH1,blocked
R11483 T14282 T14286 causeOf blocked,preventing
R11484 T14284 T14285 themeOf S209,phosphorylation
R11485 T14284 T14283 partOf S209,RPS3
R11486 T14285 T14282 themeOf phosphorylation,blocked
R11487 T14287 T14289 themeOf RPS3,translocation
R11488 T14288 T14289 locationOf nuclear,translocation
R11489 T14289 T14286 themeOf translocation,preventing
R11490 T14291 T14290 themeOf phospho,low
R11491 T14292 T14291 themeOf RPS3,phospho
R11492 T14293 T14296 causeOf ΔnleH1,intense
R11493 T14294 T14296 themeOf phospho,intense
R11494 T14295 T14294 themeOf RPS3,phospho
R11495 T14297 T14298 causeOf NleH1,inhibits
R11496 T14300 T14301 themeOf S209,phosphorylation
R11497 T14300 T14299 partOf S209,RPS3
R11498 T14301 T14298 themeOf phosphorylation,inhibits
R13949 T17474 T17475 themeOf NleH1,autophosphorylated
R13951 T17475 T17476 themeOf autophosphorylated,depends
R13953 T17477 T17476 causeOf lysine 159,depends
R13954 T17477 T17474 partOf lysine 159,NleH1
R13957 T17478 T17479 causeOf NleH1,inhibits
R13959 T17498 T17499 themeOf NleH1,expression
R13960 T17481 T17482 themeOf S209,phosphorylation
R13961 T17481 T17480 partOf S209,RPS3
R13962 T17482 T17479 themeOf phosphorylation,inhibits
R13963 T17499 T17500 causeOf expression,reduced
R13964 T17485 T17486 themeOf NleH1,autophosphorylated
R13965 T17500 T17505 themeOf reduced,failed
R13966 T17487 T17489 causeOf K159A,kinase-dead
R13967 T17487 T17488 partOf K159A,NleH1
R13968 T17488 T17489 themeOf NleH1,kinase-dead
R13969 T17501 T17500 themeOf induced,reduced
R13970 T17492 T17490 themeOf inhibit,required
R13971 T17503 T17504 themeOf S209,phosphorylation
R13972 T17494 T17492 themeOf phosphorlyation,inhibit
R13973 T17503 T17502 partOf S209,RPS3
R13974 T17496 T17494 themeOf S209,phosphorlyation
R13975 T17496 T17495 partOf S209,RPS3
R13976 T17504 T17501 themeOf phosphorylation,induced
R13977 T17508 T17507 themeOf protect,required
R13978 T17509 T17512 themeOf RPS3,phosphorylation
R13979 T17572 T17573 causeOf SSEE IKKβ,triggered
R13980 T17510 T17511 causeOf IKKβ,mediated
R13981 T17574 T17576 themeOf RPS3,translocation
R13982 T17511 T17508 themeOf mediated,protect
R13983 T17575 T17576 locationOf nuclear,translocation
R13984 T17576 T17573 themeOf translocation,triggered
R13985 T17512 T17511 themeOf phosphorylation,mediated
R13986 T17578 T17577 themeOf IKKβ,kinase-dead
R13987 T17578 T17579 themeOf IKKβ,SSAA
R13988 T17580 T17582 themeOf RPS3,accumulation
R13989 T17513 T17514 causeOf NleH,inhibited
R13990 T17581 T17582 locationOf nuclear,accumulation
R13991 T17582 T17583 themeOf accumulation,retarded
R13992 T17513 T17515 causeOf NleH,inhibited
R13993 T17516 T17518 themeOf RPS3,translocation
R13994 T17586 T17588 themeOf RPS3,translocation
R13995 T17587 T17588 locationOf nuclear,translocation
R13996 T17589 T17593 themeOf IKKβ,expressing
R13997 T17517 T17518 locationOf nuclear,translocation
R13998 T17590 T17591 themeOf IKKβ,SSEE
R13999 T17590 T17592 themeOf IKKβ,expressing
R14000 T17518 T17514 themeOf translocation,inhibited
R14001 T17519 T17520 causeOf RPS3,dependent
R14002 T17520 T17515 themeOf dependent,inhibited
R14003 T17521 T17522 themeOf luciferase,activity
R14004 T17595 T17597 themeOf RPS3,translocation
R14005 T17522 T17520 themeOf activity,dependent
R14006 T17596 T17597 locationOf nuclear,translocation
R14007 T17597 T17594 themeOf translocation,affect
R14008 T17598 T17599 themeOf IKKβ,SSAA
R14009 T17525 T17526 themeOf S209,phosphorylation
R14010 T17598 T17600 themeOf IKKβ,expressing
R14011 T17525 T17524 partOf S209,RPS3
R14012 T17529 T17530 themeOf S209,phosphorylation
R14013 T17601 T17602 causeOf NleH1,inhibit
R14014 T17603 T17605 themeOf RPS3,translocation
R14015 T17604 T17605 locationOf nuclear,translocation
R14016 T17605 T17602 themeOf translocation,inhibit
R14017 T17529 T17528 partOf S209,RPS3
R14018 T17530 T17527 themeOf phosphorylation,increase
R14019 T17608 T17606 themeOf IKKβ,expressing
R14020 T17608 T17607 themeOf IKKβ,activated
R14021 T17531 T17534 themeOf augmentation,reduced
R14022 T17532 T17533 themeOf RPS3,phosphorylation
R14023 T17609 T17613 causeOf NleH1,inhibiting
R14024 T17610 T17612 causeOf phosphorylate,thus
R14025 T17533 T17531 themeOf phosphorylation,augmentation
R14026 T17611 T17610 themeOf IKKβ,phosphorylate
R14027 T17613 T17612 themeOf inhibiting,thus
R14028 T17535 T17536 themeOf RPS3,phosphorylation
R14029 T17614 T17615 causeOf IKKβ,mediated
R14030 T17615 T17613 themeOf mediated,inhibiting
R14031 T17536 T17537 themeOf phosphorylation,enhanced
R14032 T17617 T17618 themeOf S209,phosphorylation
R14033 T17617 T17616 partOf S209,RPS3
R14034 T17618 T17615 themeOf phosphorylation,mediated
R14035 T17538 T17537 causeOf lacking,enhanced
R14036 T17621 T17622 themeOf IKKβ,autophosphorylation
R14037 T17621 T17624 themeOf IKKβ,phosphorylation
R14038 T17539 T17538 themeOf NleH,lacking
R14039 T17626 T17625 themeOf IKKβ,32P incorporation
R14040 T17544 T17543 themeOf NleH1,express
R14041 T17630 T17631 causeOf IKKβ,phosphorylated
R14042 T17630 T17632 causeOf IKKβ,phosphorylated
R14043 T17633 T17631 themeOf RPS3,phosphorylated
R14044 T17633 T17635 themeOf RPS3,substrate specificity
R14045 T17546 T17547 causeOf NleH1,abolished
R14046 T17634 T17632 themeOf GST-IκBα,phosphorylated
R14047 T17637 T17638 causeOf NleH1,reduced
R14048 T17637 T17639 causeOf NleH1,reduced
R14049 T17548 T17549 causeOf TNF,induced
R14050 T17640 T17641 causeOf IKKβ,mediated
R14051 T17641 T17638 themeOf mediated,reduced
R14052 T17642 T17643 themeOf RPS3,phosphorylation
R14053 T17643 T17641 themeOf phosphorylation,mediated
R14054 T17549 T17547 themeOf induced,abolished
R14055 T17644 T17645 causeOf IKKβ,mediated
R14056 T17645 T17639 themeOf mediated,reduced
R14057 T17551 T17552 themeOf S209,phosphorylation
R14058 T17646 T17647 themeOf GST-IκBα,phosphorylation
R14059 T17647 T17645 themeOf phosphorylation,mediated
R14060 T17648 T17651 causeOf NleH1,mediated
R14061 T17648 T17652 causeOf NleH1,mediated
R14062 T17648 T17650 causeOf NleH1,mediated
R14063 T17648 T17649 causeOf NleH1,mediated
R14064 T17551 T17550 partOf S209,RPS3
R14065 T17552 T17549 themeOf phosphorylation,induced
R14066 T17653 T17652 themeOf phosphorylation,mediated
R14067 T17654 T17651 themeOf phosphorylation,mediated
R14068 T17554 T17555 themeOf RPS3,phosphorylation
R14069 T17655 T17649 themeOf autophosphorylation,mediated
R14070 T17656 T17650 themeOf autophosphorylation,mediated
R14071 T17657 T17654 themeOf RPS3,phosphorylation
R14072 T17657 T17656 themeOf RPS3,autophosphorylation
R14073 T17658 T17653 themeOf GST-IκBα,phosphorylation
R14074 T17658 T17655 themeOf GST-IκBα,autophosphorylation
R14075 T17662 T17663 causeOf IKKβ,mediated
R14076 T17555 T17553 themeOf phosphorylation,inhibit
R14077 T17663 T17661 themeOf mediated,inhibiting
R14078 T17665 T17666 themeOf S209,phosphorylation
R14079 T17665 T17664 partOf S209,RPS3
R14080 T17666 T17663 themeOf phosphorylation,mediated
R14081 T17558 T17557 themeOf block,required
R14082 T17558 T17563 causeOf block,impair
R14083 T17560 T17561 themeOf S209,phosphorylation
R14084 T17560 T17559 partOf S209,RPS3
R14085 T17561 T17558 themeOf phosphorylation,block
R14086 T17564 T17565 locationOf nuclear,translocation
R14089 T17565 T17567 themeOf translocation,trigged
R14090 T17566 T17565 themeOf RPS3,translocation
R14093 T17567 T17563 themeOf trigged,impair
R14095 T17569 T17567 causeOf IKKβ,trigged
R14099 T17569 T17568 themeOf IKKβ,constitutively-active
R14100 T17570 T17571 themeOf IKKβ,SSEE
R15990 T20023 T20024 themeOf RPS3,translocate
R15991 T20024 T20022 themeOf translocate,triggers
R15992 T20025 T20024 locationOf nucleus,translocate
R15993 T20026 T20027 causeOf IKKβ,mediated
R15994 T20027 T20031 causeOf mediated,critical
R15995 T20028 T20033 themeOf RPS3,import
R15996 T20029 T20030 themeOf S209,phosphorylation
R15997 T20029 T20028 partOf S209,RPS3
R15998 T20030 T20027 themeOf phosphorylation,mediated
R15999 T20032 T20033 locationOf nuclear,import
R16000 T20033 T20031 themeOf import,critical
R16001 T20037 T20039 causeOf IKKβ,phosphorylated
R16002 T20038 T20040 causeOf IKKα,phosphorylated
R16003 T20039 T20043 causeOf phosphorylated,modulation
R16004 T20040 T20042 causeOf phosphorylated,modulation
R16005 T20041 T20039 themeOf RPS3,phosphorylated
R16006 T20041 T20040 themeOf RPS3,phosphorylated
R16007 T20044 T20046 themeOf RPS3,translocation
R16008 T20045 T20046 locationOf nuclear,translocation
R16009 T20046 T20043 themeOf translocation,modulation
R16010 T20046 T20042 themeOf translocation,modulation
R16011 T20046 T20047 themeOf translocation,via
R16012 T20049 T20048 themeOf p65,phosphorylate
R16013 T20052 T20050 themeOf IKKβ,bind
R16014 T20052 T20051 themeOf IKKβ,phosphorylate
R16015 T20053 T20054 themeOf IKKβ,bound
R16016 T20054 T20055 causeOf bound,account for
R16017 T20056 T20057 themeOf RPS3,phosphorylation
R16018 T20057 T20055 themeOf phosphorylation,account for
R16019 T20061 T20062 causeOf IKKβ,mediated
R16020 T20062 T20066 themeOf mediated,modulated
R16021 T20064 T20065 themeOf S209,phosphorylation
R16022 T20064 T20063 partOf S209,RPS3
R16023 T20065 T20062 themeOf phosphorylation,mediated
R16024 T20067 T20068 themeOf NleH1,binds
R16025 T20069 T20068 themeOf RPS3,binds
R16026 T20070 T20071 causeOf NleH1,inhibits
R16027 T20071 T20074 causeOf inhibits,retarding
R16028 T20072 T20073 themeOf RPS3,phosphorylation
R16029 T20072 T20076 themeOf RPS3,translocation
R16030 T20073 T20071 themeOf phosphorylation,inhibits
R16031 T20075 T20076 locationOf nuclear,translocation
R16032 T20076 T20074 themeOf translocation,retarding
R16033 T20079 T20078 themeOf IKKβ,phosphorylate
R16034 T20081 T20082 causeOf IKKβ,mediated
R16035 T20082 T20080 themeOf mediated,inhibit
R16036 T20084 T20085 themeOf S209,phosphorylation
R16037 T20084 T20083 partOf S209,RPS3
R16038 T20085 T20082 themeOf phosphorylation,mediated
R16039 T20086 T20087 causeOf NleH1,steer
R16040 T20088 T20087 themeOf IKKβ,steer
R16041 T20092 T20093 causeOf NleH1,block
R16042 T20094 T20096 themeOf p65,translocation
R16043 T20095 T20096 locationOf nuclear,translocation
R16044 T20096 T20093 themeOf translocation,block
R16045 T20100 T20099 themeOf RPS3,inhibiting
R16046 T20101 T20099 causeOf NleH1,inhibiting
R16047 T20103 T20102 themeOf RPS3,impeding
R16048 T20105 T20107 themeOf p65,translocation
R16049 T20106 T20107 locationOf nuclear,translocation
R16050 T20107 T20104 themeOf translocation,altering
R16051 T20109 T20108 themeOf RPS3,effects

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T499 0-4 Protein denotes IKKβ
T500 31-35 Protein denotes RPS3
T501 62-67 Protein denotes NF-κB
T502 5-20 Phosphorylation denotes phosphorylation
T503 36-43 Entity denotes nuclear
T504 44-57 Localization denotes translocation
T505 21-30 Regulation denotes regulates
T506 130-135 Protein denotes NF-κB
T507 186-206 Protein denotes ribosomal protein S3
T508 208-212 Protein denotes RPS3
T509 220-225 Protein denotes NF-κB
T510 303-307 Protein denotes RPS3
T511 308-315 Entity denotes nuclear
T512 316-329 Localization denotes translocation
T513 333-342 Regulation denotes regulated
T514 364-368 Protein denotes IKKβ
T515 422-426 Protein denotes RPS3
T516 369-384 Phosphorylation denotes phosphorylation
T517 427-434 Entity denotes nuclear
T518 435-447 Localization denotes localization
T519 410-417 Positive_regulation denotes crucial
T520 559-564 Protein denotes NleH1
T521 588-597 Protein denotes RPS3 S209
T522 626-630 Protein denotes RPS3
T523 598-613 Phosphorylation denotes phosphorylation
T524 618-625 Negative_regulation denotes blocked
T525 578-587 Negative_regulation denotes inhibited
T526 771-775 Protein denotes IKKβ
T527 827-831 Protein denotes RPS3
T528 850-855 Protein denotes NF-κB
T529 832-840 Positive_regulation denotes promotes
T1613 939-961 Protein denotes Nuclear Factor-kappa B
T1614 963-968 Protein denotes NF-κB
T1615 1150-1174 Protein denotes mammalian NF-κB subunits
T1616 1179-1191 Protein denotes Rel proteins
T1617 1203-1207 Protein denotes RelA
T1618 1209-1212 Protein denotes p65
T1619 1215-1219 Protein denotes RelB
T1620 1221-1226 Protein denotes c-Rel
T1621 1228-1231 Protein denotes p50
T1622 1237-1240 Protein denotes p52
T1623 1294-1314 Protein denotes ribosomal protein S3
T1624 1316-1320 Protein denotes RPS3
T1625 1365-1381 Protein denotes NF-κB complexes6
T1626 1383-1387 Protein denotes RPS3
T1627 1427-1432 Protein denotes NF-κB
T1628 1530-1535 Protein denotes NF-κB
T1629 1564-1568 Protein denotes RPS3
T1630 1583-1588 Protein denotes NF-κB
T1631 1636-1669 Protein denotes immunoglobulin κ light chain gene
T1632 1569-1579 Regulation denotes regulation
T1633 1569-1579 Regulation denotes regulation
T1634 1670-1680 Gene_expression denotes expression
T1635 1908-1913 Protein denotes NleH1
T1636 1933-1938 Protein denotes NF-κB
T1637 1980-1984 Protein denotes RPS3
T1638 2026-2029 Protein denotes p65
T1639 2030-2043 Protein denotes localization9
T1640 1867-1876 Localization denotes secretion
T1641 1951-1964 Transcription denotes transcription
T1642 1985-1992 Entity denotes nuclear
T1643 1993-2006 Localization denotes translocation
T1644 1968-1979 Negative_regulation denotes attenuating
T1645 2071-2076 Protein denotes NF-κB
T1646 2103-2107 Protein denotes RPS3
T1647 2190-2210 Protein denotes ribosomal proteins10
T1648 2108-2115 Entity denotes nuclear
T1649 2116-2129 Localization denotes translocation
T1650 2096-2102 Positive_regulation denotes induce
T1651 2243-2264 Protein denotes 40S ribosomal subunit
T1652 2266-2270 Protein denotes RPS3
T1653 2353-2357 Protein denotes RPS3
T1654 2361-2375 Phosphorylation denotes phosphorylated
T1655 2451-2456 Protein denotes NF-κB
T1656 2487-2491 Protein denotes RPS3
T1657 2528-2533 Protein denotes NF-κB
T1658 2457-2467 Regulation denotes regulation
T1659 2495-2509 Phosphorylation denotes phosphorylated
T1660 2534-2544 Positive_regulation denotes activation
T1661 2672-2676 Protein denotes RPS3
T1662 2740-2760 Protein denotes κB (IκB) kinase beta
T1663 2762-2766 Protein denotes IKKβ
T1664 2783-2787 Protein denotes RPS3
T1665 2727-2736 Negative_regulation denotes Inhibitor
T1666 2727-2736 Negative_regulation denotes Inhibitor
T1667 2791-2797 Entity denotes serine
T1668 2768-2782 Phosphorylation denotes phosphorylated
T1669 2810-2819 Protein denotes RPS3 S209
T1670 2866-2876 Protein denotes importin-α
T1671 2888-2892 Protein denotes RPS3
T1672 2908-2919 Protein denotes karyopherin
T1673 2820-2835 Phosphorylation denotes phosphorylation
T1674 2849-2860 Binding denotes association
T1675 2878-2887 Positive_regulation denotes mediating
T1677 2940-2953 Localization denotes translocation
T1678 2940-2953 Localization denotes translocation
T1679 2836-2844 Positive_regulation denotes enhanced
T1680 2975-2994 Protein denotes coli NleH1 effector
T1681 3018-3027 Protein denotes RPS3 S209
T1682 3045-3054 Protein denotes coli O157
T1683 3055-3057 Protein denotes H7
T1684 3008-3017 Negative_regulation denotes inhibited
T2366 3126-3130 Protein denotes RPS3
T2367 3162-3167 Protein denotes NF-κB
T2368 3131-3146 Phosphorylation denotes phosphorylation
T2369 3168-3178 Positive_regulation denotes activation
T2370 3168-3178 Positive_regulation denotes activation
T2371 3150-3158 Positive_regulation denotes response
T2372 3150-3158 Positive_regulation denotes response
T2373 3195-3199 Protein denotes RPS3
T2374 3225-3230 Protein denotes NF-κB
T2375 3284-3305 Protein denotes tumor necrosis factor
T2376 3307-3310 Protein denotes TNF
T2377 3323-3331 Protein denotes HEK 293T
T2378 3203-3217 Phosphorylation denotes phosphorylated
T2379 3231-3241 Positive_regulation denotes activation
T2380 3345-3349 Protein denotes RPS3
T2381 3458-3461 Protein denotes TNF
T2382 3497-3509 Protein denotes RPS3 protein
T2383 3511-3518 Protein denotes Fig. 1a
T2384 3363-3377 Phosphorylation denotes phosphorylated
T2385 3462-3473 Positive_regulation denotes stimulation
T2386 3485-3493 Positive_regulation denotes increase
T2387 3485-3493 Positive_regulation denotes increase
T2388 3540-3544 Protein denotes RPS3
T2389 3597-3601 Protein denotes RPS3
T2390 3559-3573 Phosphorylation denotes phosphorylated
T2391 3718-3721 Protein denotes TNF
T2392 3821-3825 Protein denotes IκBα
T2393 3864-3868 Protein denotes RPS3
T2394 3787-3802 Phosphorylation denotes phosphorylation
T2395 3807-3817 Protein_catabolism denotes degradaion
T2396 3869-3884 Phosphorylation denotes phosphorylation
T2397 3770-3780 Positive_regulation denotes stimulated
T2398 3770-3780 Positive_regulation denotes stimulated
T2399 3770-3780 Positive_regulation denotes stimulated
T2400 3770-3780 Positive_regulation denotes stimulated
T2401 4027-4031 Protein denotes RPS3
T2402 4033-4040 Protein denotes Fig. 1b
T2403 3998-4023 Phosphorylation denotes threonine-phosphorylation
T3048 4044-4048 Protein denotes RPS3
T3049 4053-4057 Protein denotes IKKβ
T3050 4105-4114 Protein denotes κB kinase
T3051 4116-4119 Protein denotes IKK
T3052 4149-4161 Protein denotes subunit IKKγ
T3053 4190-4194 Protein denotes IKKα
T3054 4199-4203 Protein denotes IKKβ
T3055 4092-4101 Negative_regulation denotes inhibitor
T3056 4092-4101 Negative_regulation denotes inhibitor
T3057 4122-4132 Gene_expression denotes consisting
T3058 4122-4132 Gene_expression denotes consisting
T3059 4122-4132 Gene_expression denotes consisting
T3060 4074-4084 Positive_regulation denotes activation
T3061 4074-4084 Positive_regulation denotes activation
T3062 4092-4101 Negative_regulation denotes inhibitor
T3063 4092-4101 Negative_regulation denotes inhibitor
T3064 4092-4101 Negative_regulation denotes inhibitor
T3065 4322-4326 Protein denotes RPS3
T3066 4359-4362 Protein denotes p65
T3067 4363-4366 Protein denotes p50
T3068 4367-4371 Protein denotes IκBα
T3069 4441-4445 Protein denotes IKKβ
T3070 4483-4487 Protein denotes RPS3
T3071 4334-4339 Binding denotes found
T3072 4431-4440 Positive_regulation denotes activated
T3073 4457-4461 Binding denotes bind
T3074 4469-4482 Phosphorylation denotes phosphorylate
T3075 4469-4482 Phosphorylation denotes phosphorylate
T3076 4532-4536 Protein denotes IKKβ
T3077 4541-4545 Protein denotes RPS3
T3078 4558-4565 Protein denotes Fig. 1c
T3079 4522-4531 Gene_expression denotes expressed
T3080 4522-4531 Gene_expression denotes expressed
T3081 4546-4556 Binding denotes interacted
T3082 4546-4556 Binding denotes interacted
T3083 4546-4556 Binding denotes interacted
T3084 4639-4643 Protein denotes IKKβ
T3085 4644-4648 Protein denotes RPS3
T3086 4709-4714 Protein denotes NF-κB
T3087 4649-4660 Binding denotes interaction
T3088 4715-4728 Transcription denotes transcription
T3089 4775-4779 Protein denotes RPS3
T3090 4780-4784 Protein denotes IKKβ
T3091 4824-4827 Protein denotes TNF
T3092 4901-4905 Protein denotes RPS3
T3093 4906-4912 Entity denotes serine
T3094 4913-4928 Phosphorylation denotes phosphorylation
T3095 4997-5001 Protein denotes RPS3
T3096 5006-5010 Protein denotes IKKα
T3097 5012-5019 Protein denotes Fig. 1d
T3098 4977-4988 Binding denotes interaction
T4274 5023-5027 Protein denotes IKKβ
T4275 5044-5048 Protein denotes RPS3
T4276 5049-5056 Entity denotes nuclear
T4277 5057-5070 Localization denotes translocation
T4278 5031-5039 Positive_regulation denotes required
T4279 5094-5098 Protein denotes RPS3
T4280 5099-5103 Protein denotes IKKβ
T4281 5132-5136 Protein denotes RPS3
T4282 5176-5180 Protein denotes IKKα
T4283 5184-5188 Protein denotes IKKβ
T4284 5273-5277 Protein denotes RPS3
T4285 5104-5115 Binding denotes interaction
T4286 5137-5144 Entity denotes nuclear
T4287 5145-5158 Localization denotes translocation
T4288 5189-5199 Gene_expression denotes expression
T4289 5189-5199 Gene_expression denotes expression
T4290 5278-5285 Entity denotes nuclear
T4291 5286-5295 Localization denotes migration
T4292 5119-5127 Positive_regulation denotes required
T4293 5253-5272 Positive_regulation denotes stimulation-induced
T4294 5325-5328 Protein denotes TNF
T4295 5333-5338 Protein denotes PMA+I
T4296 5349-5353 Protein denotes RPS3
T4297 5354-5361 Entity denotes nuclear
T4298 5362-5375 Localization denotes translocation
T4299 5362-5375 Localization denotes translocation
T4300 5362-5375 Localization denotes translocation
T4301 5456-5460 Protein denotes RPS3
T4302 5525-5529 Protein denotes IKKα
T4303 5461-5468 Entity denotes nuclear
T4304 5469-5482 Localization denotes translocation
T4305 5530-5539 Negative_regulation denotes silencing
T4306 5566-5570 Protein denotes IKKβ
T4307 5592-5596 Protein denotes RPS3
T4308 5641-5648 Protein denotes Fig. 2a
T4309 5553-5562 Negative_regulation denotes knockdown
T4310 5597-5604 Entity denotes nuclear
T4311 5605-5617 Localization denotes accumulation
T4312 5571-5581 Negative_regulation denotes attenuated
T4313 5721-5725 Protein denotes IKKβ
T4314 5735-5739 Protein denotes IKKα
T4315 5778-5782 Protein denotes RPS3
T4316 5707-5717 Gene_expression denotes expression
T4317 5707-5717 Gene_expression denotes expression
T4318 5783-5790 Entity denotes nuclear
T4319 5791-5804 Localization denotes translocation
T4320 5759-5777 Positive_regulation denotes activation-induced
T4321 5850-5853 Protein denotes p65
T4322 5854-5861 Entity denotes nuclear
T4323 5862-5875 Localization denotes translocation
T4324 5880-5887 Negative_regulation denotes blocked
T4325 5971-5975 Protein denotes RPS3
T4326 6073-6077 Protein denotes IKKβ
T4327 5946-5953 Entity denotes nuclear
T4328 5954-5967 Localization denotes translocation
T4329 5997-6007 Gene_expression denotes expressing
T4330 6135-6139 Protein denotes IKKβ
T4331 6148-6153 Protein denotes NF-κB
T4332 6164-6174 Protein denotes luciferase
T4333 6140-6147 Positive_regulation denotes induced
T4334 6218-6222 Protein denotes RPS3
T4335 6245-6249 Protein denotes IKKβ
T4336 6320-6324 Protein denotes RPS3
T4337 6373-6377 Protein denotes IKKβ
T4338 6379-6383 Protein denotes SSEE
T4339 6256-6267 Gene_expression denotes -expressing
T4340 6306-6316 Gene_expression denotes proportion
T4341 6345-6352 Entity denotes nucleus
T4342 6362-6372 Gene_expression denotes expressing
T4343 6362-6372 Gene_expression denotes expressing
T4344 6325-6337 Localization denotes translocated
T4345 6482-6486 Protein denotes IKKβ
T4346 6488-6492 Protein denotes SSEE
T4347 6523-6527 Protein denotes IKKβ
T4348 6493-6504 Gene_expression denotes -expressing
T4349 6493-6504 Gene_expression denotes -expressing
T4350 6534-6545 Gene_expression denotes -expressing
T4351 6462-6471 Positive_regulation denotes increased
T4352 6593-6597 Protein denotes IKKβ
T4353 6639-6643 Protein denotes RPS3
T4354 6681-6686 Protein denotes NF-κB
T4355 6644-6651 Entity denotes nuclear
T4356 6652-6665 Localization denotes translocation
T4357 6610-6619 Positive_regulation denotes necessary
T6207 6708-6712 Protein denotes IκBα
T6208 6729-6733 Protein denotes RPS3
T6209 6713-6724 Protein_catabolism denotes degradation
T6210 6734-6741 Entity denotes nuclear
T6211 6742-6755 Localization denotes translocation
T6212 6756-6766 Protein denotes Importin-α
T6213 6799-6819 Protein denotes NF-κB Rel subunits23
T6214 6781-6788 Entity denotes nuclear
T6215 6789-6795 Localization denotes import
T6216 6767-6776 Regulation denotes regulates
T6217 6825-6829 Protein denotes RPS3
T6218 6958-6961 Protein denotes p65
T6219 6962-6976 Protein denotes translocation6
T6220 6891-6898 Entity denotes nuclear
T6221 6899-6912 Localization denotes translocation
T6222 6899-6912 Localization denotes translocation
T6223 6899-6912 Localization denotes translocation
T6224 6997-7001 Protein denotes RPS3
T6225 7025-7037 Protein denotes importin-α/β
T6226 7076-7080 Protein denotes RPS3
T6227 7098-7108 Protein denotes importin-α
T6228 7146-7149 Protein denotes TNF
T6229 7168-7175 Protein denotes Fig. 3a
T6230 7081-7092 Binding denotes association
T6231 7134-7142 Positive_regulation denotes enhanced
T6232 7209-7213 Protein denotes RPS3
T6233 7225-7235 Protein denotes importin-α
T6234 7282-7287 Protein denotes NF-κB
T6235 7214-7221 Binding denotes binding
T6236 7253-7260 Entity denotes nuclear
T6237 7306-7310 Protein denotes IκBα
T6238 7362-7365 Protein denotes p65
T6239 7376-7380 Protein denotes RPS3
T6240 7385-7389 Protein denotes IκBα
T6241 7398-7401 Protein denotes p65
T6242 7459-7478 Protein denotes IκBα degradation is
T6243 7510-7514 Protein denotes RPS3
T6244 7311-7322 Protein_catabolism denotes degradation
T6245 7390-7394 Binding denotes bind
T6246 7390-7394 Binding denotes bind
T6247 7390-7394 Binding denotes bind
T6248 7496-7506 Protein_catabolism denotes liberation
T6249 7479-7487 Positive_regulation denotes required
T6250 7547-7551 Protein denotes RPS3
T6251 7597-7611 Protein denotes wild-type IκBα
T6252 7618-7629 Protein denotes IκBα mutant
T6253 7631-7635 Protein denotes SSAA
T6254 7650-7654 Protein denotes IKKβ
T6255 7532-7543 Binding denotes association
T6256 7582-7596 Positive_regulation denotes overexpressing
T6257 7582-7596 Positive_regulation denotes overexpressing
T6258 7582-7596 Positive_regulation denotes overexpressing
T6259 7663-7678 Phosphorylation denotes phosphorylation
T6260 7663-7678 Phosphorylation denotes phosphorylation
T6261 7683-7694 Protein_catabolism denotes degradation
T6262 7683-7694 Protein_catabolism denotes degradation
T6263 7637-7646 Positive_regulation denotes resistant
T6264 7637-7646 Positive_regulation denotes resistant
T6265 7655-7662 Positive_regulation denotes induced
T6266 7655-7662 Positive_regulation denotes induced
T6267 7732-7736 Protein denotes IκBα
T6268 7738-7741 Protein denotes TNF
T6269 7783-7787 Protein denotes RPS3
T6270 7792-7802 Protein denotes importin-α
T6271 7705-7716 Gene_expression denotes transfected
T6272 7705-7716 Positive_regulation denotes transfected
T6273 7768-7779 Binding denotes interaction
T6274 7754-7763 Positive_regulation denotes augmented
T6275 7886-7890 Protein denotes RPS3
T6276 7962-7966 Protein denotes IκBα
T6277 7968-7975 Protein denotes Fig. 3b
T6278 7947-7961 Protein_catabolism denotes non-degradable
T6279 7947-7961 Protein_catabolism denotes non-degradable
T6280 7997-8001 Protein denotes IκBα
T6281 8045-8049 Protein denotes RPS3
T6282 8090-8094 Protein denotes RPS3
T6283 8095-8103 Protein denotes importin
T6284 8130-8134 Protein denotes RPS3
T6285 8150-8154 Protein denotes IκBα
T6286 8050-8057 Entity denotes nuclear
T6287 8058-8071 Localization denotes translocation
T6288 8155-8165 Gene_expression denotes expression
T6289 8034-8044 Positive_regulation denotes precluding
T6290 8141-8149 Negative_regulation denotes reducing
T6291 8219-8223 Protein denotes IκBα
T6292 8244-8248 Protein denotes IκBα
T6293 8235-8243 Negative_regulation denotes depleted
T6294 8301-8305 Protein denotes RPS3
T6295 8386-8390 Protein denotes RPS3
T6296 8337-8346 Positive_regulation denotes augmented
T6297 8474-8478 Protein denotes IκBα
T6298 8576-8580 Protein denotes RPS3
T6299 8585-8595 Protein denotes importin-α
T6300 8597-8600 Protein denotes Fig
T6301 8602-8604 Protein denotes 3e
T6302 8609-8630 Protein denotes Supplementary Fig. 3b
T6303 8659-8663 Protein denotes RPS3
T6304 8719-8721 Protein denotes 3c
T6305 8479-8490 Protein_catabolism denotes degradation
T6306 8635-8642 Entity denotes nuclear
T6307 8643-8655 Positive_regulation denotes accumulation
T6308 8467-8473 Positive_regulation denotes induce
T6309 8546-8555 Positive_regulation denotes increased
T6310 8768-8770 Protein denotes κB
T6311 8816-8826 Protein denotes importin-α
T6312 8864-8868 Protein denotes RPS3
T6313 8875-8879 Protein denotes IκBα
T6314 8827-8838 Binding denotes association
T6315 8880-8891 Protein_catabolism denotes degradation
T6316 8880-8891 Protein_catabolism denotes degradation
T6317 8803-8811 Positive_regulation denotes promotes
T6318 8907-8910 Protein denotes TNF
T6319 8967-8971 Protein denotes RPS3
T6320 9010-9013 Protein denotes TNF
T6321 9049-9053 Protein denotes IκBα
T6322 9133-9137 Protein denotes RPS3
T6323 9155-9165 Protein denotes importin-α
T6324 9054-9069 Phosphorylation denotes phosphorylation
T6325 9074-9085 Protein_catabolism denotes degradation
T6326 9138-9149 Binding denotes association
T6327 9178-9185 Entity denotes nuclear
T6328 9186-9199 Localization denotes translocation
T6329 9127-9132 Positive_regulation denotes cause
T6330 9243-9247 Protein denotes IKKβ
T6331 9267-9271 Protein denotes RPS3
T6332 9248-9263 Phosphorylation denotes phosphorylation
T6333 9248-9263 Phosphorylation denotes phosphorylation
T10980 12135-12139 Protein denotes RPS3
T10981 12148-12153 Protein denotes NF-κB
T10982 12116-12131 Phosphorylation denotes Phosphorylation
T10983 12154-12162 Gene_expression denotes function
T10984 12154-12162 Gene_expression denotes function
T10985 12254-12258 Protein denotes RPS3
T10986 12266-12271 Protein denotes NF-κB
T10987 12229-12236 Entity denotes nuclear
T10988 12237-12250 Localization denotes translocation
T10989 12272-12282 Positive_regulation denotes activation
T10990 12344-12348 Protein denotes RPS3
T10991 12397-12418 Protein denotes heat-shock protein 90
T10992 12420-12425 Protein denotes hsp90
T10993 12485-12489 Protein denotes PARP
T10994 12349-12360 Gene_expression denotes transfected
T10995 12603-12607 Protein denotes Flag
T10996 12608-12612 Protein denotes RPS3
T10997 12636-12643 Protein denotes Fig. 5a
T10998 12613-12620 Entity denotes nuclear
T10999 12621-12634 Localization denotes translocation
T11000 12621-12634 Localization denotes translocation
T11001 12621-12634 Localization denotes translocation
T11002 12655-12659 Protein denotes RPS3
T11003 12661-12666 Protein denotes S209A
T11004 12706-12713 Protein denotes Fig. 5a
T11005 12668-12675 Entity denotes nuclear
T11006 12676-12689 Localization denotes translocation
T11007 12676-12689 Localization denotes translocation
T11008 12694-12704 Negative_regulation denotes attenuated
T11009 12694-12704 Negative_regulation denotes attenuated
T11010 12745-12761 Protein denotes activating NF-κB
T11011 12780-12784 Protein denotes IKKβ
T11012 12788-12792 Protein denotes RPS3
T11013 12765-12779 Gene_expression denotes overexpressing
T11014 12793-12800 Entity denotes nuclear
T11015 12801-12814 Localization denotes translocation
T11016 12816-12820 Protein denotes IKKβ
T11017 12846-12851 Protein denotes NF-κB
T11018 12864-12874 Protein denotes luciferase
T11019 12971-12976 Protein denotes S209A
T11020 12978-12982 Protein denotes RPS3
T11021 12984-12991 Protein denotes Fig. 5b
T11022 12821-12835 Gene_expression denotes overexpression
T11023 12821-12835 Positive_regulation denotes overexpression
T11024 12927-12934 Entity denotes nuclear
T11025 12935-12948 Localization denotes translocation
T11026 12935-12948 Localization denotes translocation
T11027 12935-12948 Localization denotes translocation
T11028 12915-12922 Positive_regulation denotes induced
T11029 12915-12922 Positive_regulation denotes induced
T11030 12915-12922 Positive_regulation denotes induced
T11031 13059-13064 Protein denotes NF-κB
T11032 13084-13088 Protein denotes RPS3
T11033 13089-13096 Entity denotes nuclear
T11034 13097-13110 Localization denotes translocation
T11035 13097-13110 Localization denotes translocation
T11036 13065-13083 Positive_regulation denotes activation-induced
T11037 13065-13083 Positive_regulation denotes activation-induced
T11038 13135-13139 Protein denotes S209
T11039 13159-13163 Protein denotes RPS3
T11040 13171-13176 Protein denotes NF-κB
T11041 13218-13222 Protein denotes RPS3
T11042 13301-13310 Protein denotes RPS3 mRNA
T11043 13365-13377 Protein denotes S209A mutant
T11044 13378-13382 Protein denotes RPS3
T11045 13140-13155 Phosphorylation denotes phosphorylation
T11046 13140-13155 Phosphorylation denotes phosphorylation
T11047 13223-13233 Gene_expression denotes expression
T11203 13434-13441 Negative_regulation denotes reduced
T11204 13520-13530 Gene_expression denotes expression
T11205 13502-13508 Regulation denotes affect
T11206 13629-13633 Protein denotes RPS3
T11207 13652-13655 Protein denotes TNF
T11208 13681-13686 Protein denotes Ig κB
T11209 13694-13715 Protein denotes luciferase construct6
T11210 13717-13720 Protein denotes Fig
T11211 13722-13724 Protein denotes 5d
T11212 13634-13643 Negative_regulation denotes knockdown
T11213 13664-13674 Gene_expression denotes expression
T11214 13664-13674 Gene_expression denotes expression
T11215 13664-13674 Gene_expression denotes expression
T11216 13656-13663 Positive_regulation denotes induced
T11217 13656-13663 Positive_regulation denotes induced
T11218 13656-13663 Positive_regulation denotes induced
T11219 13644-13651 Negative_regulation denotes reduced
T11220 13644-13651 Negative_regulation denotes reduced
T11221 13644-13651 Negative_regulation denotes reduced
T11222 13740-13750 Protein denotes luciferase
T11223 13768-13772 Protein denotes RPS3
T11224 13846-13856 Protein denotes S209A RPS3
T11225 13858-13861 Protein denotes Fig
T11226 13863-13865 Protein denotes 5d
T11227 13899-13906 Protein denotes Fig. 5c
T11228 13773-13783 Negative_regulation denotes deficiency
T11229 13887-13897 Gene_expression denotes expression
T11230 13940-13944 Protein denotes RPS3
T11231 13956-13966 Protein denotes luciferase
T11232 14058-14083 Protein denotes green fluorescent protein
T11233 14085-14088 Protein denotes GFP
T11234 14151-14155 Protein denotes RPS3
T11235 13948-13955 Negative_regulation denotes restore
T11236 14040-14054 Gene_expression denotes overexpression
T11237 14040-14054 Gene_expression denotes overexpression
T11238 14040-14054 Positive_regulation denotes overexpression
T11239 14040-14054 Positive_regulation denotes overexpression
T11240 14114-14126 Binding denotes complemented
T11241 13984-13990 Positive_regulation denotes result
T11242 13984-13990 Positive_regulation denotes result
T11243 14220-14229 Protein denotes RPS3 S209
T11244 14262-14267 Protein denotes NF-κB
T11245 14301-14311 Protein denotes Ig κB site
T11246 14230-14245 Phosphorylation denotes phosphorylation
T11247 14406-14410 Protein denotes RPS3
T11248 14415-14430 Protein denotes p65 recruitment
T11249 14443-14451 Protein denotes κB sites
T11250 14479-14484 Protein denotes NF-κB
T11251 14377-14381 Entity denotes S209
T11252 14382-14397 Phosphorylation denotes phosphorylation
T11253 14485-14495 Positive_regulation denotes activation
T11254 14398-14405 Regulation denotes affects
T11255 14500-14504 Protein denotes RPS3
T11256 14612-14622 Protein denotes S209A RPS3
T11257 14630-14638 Protein denotes κB sites
T11258 14646-14652 Protein denotes NFKBIA
T11259 14657-14670 Protein denotes IL8 promoters
T11260 14672-14675 Protein denotes Fig
T11261 14505-14514 Negative_regulation denotes knockdown
T11262 14528-14538 Positive_regulation denotes stimulated
T11263 14528-14538 Positive_regulation denotes stimulated
T11264 14699-14709 Protein denotes RPS3 S209A
T11265 14727-14730 Protein denotes p65
T11266 14688-14698 Gene_expression denotes expressing
T11267 14717-14723 Regulation denotes impact
T11268 14731-14738 Entity denotes nuclear
T11269 14739-14752 Localization denotes translocation
T11270 14739-14752 Localization denotes translocation
T11271 14717-14723 Regulation denotes impact
T11272 14717-14723 Regulation denotes impact
T11273 14846-14849 Protein denotes p65
T11274 14864-14868 Protein denotes RPS3
T11275 14881-14886 Protein denotes NF-κB
T11276 14917-14921 Protein denotes CD25
T11277 14899-14908 Entity denotes promoters
T11278 14850-14860 Positive_regulation denotes attraction
T11279 14926-14935 Positive_regulation denotes increased
T11280 15029-15033 Protein denotes Flag
T11281 15034-15038 Protein denotes RPS3
T11282 15042-15045 Protein denotes p65
T11283 15061-15074 Protein denotes ACTB promoter
T11284 15083-15091 Protein denotes κB sites
T11285 15093-15096 Protein denotes Fig
T11286 15134-15141 Protein denotes κB site
T11287 15075-15082 Negative_regulation denotes lacking
T11288 15177-15181 Protein denotes RPS3
T11289 15223-15226 Protein denotes p65
T11290 15256-15260 Protein denotes S209
T11291 15162-15173 Binding denotes recruitment
T11292 15208-15219 Binding denotes recruitment
T11293 15311-15326 Protein denotes T cell receptor
T11294 15328-15331 Protein denotes TCR
T11295 15404-15408 Protein denotes RPS3
T11296 15409-15412 Protein denotes p65
T11297 15432-15444 Protein denotes IL8 κB sites
T11298 15499-15503 Protein denotes RPS3
T11299 15551-15555 Protein denotes CD25
T11300 15608-15618 Protein denotes S209A RPS3
T11301 15556-15566 Gene_expression denotes expression
T11302 15673-15682 Protein denotes RPS3 S209
T11303 15702-15706 Protein denotes IKKβ
T11304 15734-15738 Protein denotes RPS3
T11305 15752-15757 Protein denotes NF-κB
T11306 15683-15698 Phosphorylation denotes phosphorylation
T11307 15683-15698 Phosphorylation denotes phosphorylation
T11308 15721-15729 Positive_regulation denotes required
T11309 15721-15729 Positive_regulation denotes required
T11310 15742-15751 Positive_regulation denotes directing
T13037 15817-15832 Phosphorylation denotes phosphorylation
T13038 15803-15811 Negative_regulation denotes inhibits
T13039 15842-15846 Protein denotes EHEC
T13040 16062-16067 Protein denotes NF-κB
T13041 16108-16120 Protein denotes E. coli O157
T13042 16121-16130 Protein denotes H7 EDL933
T13043 16148-16153 Protein denotes NleH1
T13044 16178-16182 Protein denotes RPS3
T13045 16221-16225 Protein denotes RPS3
T13046 16236-16252 Protein denotes NF-κB signaling9
T13047 16154-16159 Binding denotes binds
T13048 16154-16159 Binding denotes binds
T13049 16154-16159 Binding denotes binds
T13050 16183-16190 Entity denotes nuclear
T13051 16191-16204 Localization denotes translocation
T13052 16226-16235 Positive_regulation denotes dependent
T13053 16211-16220 Negative_regulation denotes impairing
T13054 16285-16290 Protein denotes NleH1
T13055 16318-16327 Protein denotes RPS3 S209
T13056 16328-16343 Phosphorylation denotes phosphorylation
T13057 16307-16317 Negative_regulation denotes inhibiting
T13058 16393-16409 Protein denotes NleH1-HA plasmid
T13059 16418-16422 Protein denotes TNFα
T13060 16431-16436 Protein denotes NF-κB
T13061 16501-16506 Protein denotes NleH1
T13062 16520-16523 Protein denotes TNF
T13063 16550-16554 Protein denotes RPS3
T13064 16606-16613 Protein denotes Fig. 6c
T13065 16555-16570 Phosphorylation denotes phosphorylation
T13066 16524-16531 Positive_regulation denotes induced
T13067 16507-16514 Negative_regulation denotes reduced
T13068 16627-16632 Protein denotes NleH1
T13069 16664-16667 Protein denotes TNF
T13070 16676-16679 Protein denotes IKK
T13071 16694-16698 Protein denotes IκBα
T13072 16740-16745 Protein denotes NleH1
T13073 16756-16782 Protein denotes p65 nuclear translocation9
T13074 16784-16791 Protein denotes Fig. 6c
T13075 16616-16626 Gene_expression denotes Expressing
T13076 16699-16710 Protein_catabolism denotes degradation
T13077 16732-16736 Negative_regulation denotes lack
T13078 16732-16736 Negative_regulation denotes lack
T13079 16732-16736 Negative_regulation denotes lack
T13080 16810-16815 Protein denotes NleH1
T13081 16825-16829 Protein denotes RPS3
T13082 16928-16933 Protein denotes nleH1
T13083 16935-16941 Protein denotes ΔnleH1
T13084 17003-17008 Protein denotes NleH1
T13085 16830-16845 Phosphorylation denotes phosphorylation
T13086 16913-16920 Negative_regulation denotes lacking
T13087 16913-16920 Negative_regulation denotes lacking
T13088 16816-16824 Negative_regulation denotes inhibits
T13089 17060-17063 Protein denotes TNF
T13090 17107-17116 Protein denotes RPS3 S209
T13091 17117-17132 Phosphorylation denotes phosphorylation
T13092 17095-17103 Positive_regulation denotes increase
T13093 17180-17189 Protein denotes RPS3 S209
T13094 17190-17205 Phosphorylation denotes phosphorylation
T13095 17224-17232 Negative_regulation denotes impaired
T13096 17302-17305 Protein denotes TNF
T13097 17314-17323 Protein denotes RPS3 S209
T13098 17385-17400 Protein denotes ΔnleH1 or ΔescN
T13099 17402-17409 Protein denotes Fig. 6d
T13100 17324-17339 Phosphorylation denotes phosphorylation
T13101 17306-17313 Positive_regulation denotes induced
T13102 17344-17354 Negative_regulation denotes unimpaired
T13103 17457-17463 Protein denotes ΔnleH1
T13104 17467-17488 Protein denotes ΔescN E. coli O157:H7
T13105 17514-17517 Protein denotes TNF
T13106 17526-17530 Protein denotes RPS3
T13107 17531-17538 Entity denotes nuclear
T13108 17539-17553 Localization denotes translocation9
T13109 17518-17525 Positive_regulation denotes induced
T13110 17503-17513 Negative_regulation denotes attenuated
T13111 17503-17513 Negative_regulation denotes attenuated
T13112 17576-17580 Protein denotes RPS3
T13113 17691-17696 Protein denotes NF-κB
T13114 17728-17737 Protein denotes RPS3 S209
T13115 17581-17596 Phosphorylation denotes phosphorylation
T13116 17605-17612 Entity denotes nuclear
T13117 17613-17626 Localization denotes translocation
T13118 17738-17753 Phosphorylation denotes phosphorylation
T13119 17771-17778 Entity denotes nuclear
T13120 17813-17818 Protein denotes NleH1
T13121 17828-17837 Protein denotes RPS3 S209
T13122 17891-17895 Protein denotes RPS3
T13123 17906-17911 Protein denotes NF-κB
T13124 17944-17947 Protein denotes IL8
T13125 17949-17955 Protein denotes NFKBIA
T13126 17961-17968 Protein denotes TNFAIP3
T13127 17838-17853 Phosphorylation denotes phosphorylation
T13128 17924-17937 Transcription denotes transcription
T13129 17924-17937 Transcription denotes transcription
T13130 17924-17937 Transcription denotes transcription
T13131 17924-17937 Transcription denotes transcription
T13132 17819-17827 Negative_regulation denotes inhibits
T13133 17884-17890 Negative_regulation denotes blocks
T13134 17884-17890 Negative_regulation denotes blocks
T13135 17884-17890 Negative_regulation denotes blocks
T13136 17884-17890 Negative_regulation denotes blocks
T13137 17896-17905 Positive_regulation denotes dependent
T13138 17896-17905 Positive_regulation denotes dependent
T13139 17896-17905 Positive_regulation denotes dependent
T13140 17896-17905 Positive_regulation denotes dependent
T13141 18185-18190 Protein denotes nleH1
T13142 18226-18230 Protein denotes RPS3
T13143 18260-18264 Protein denotes CD25
T13144 18269-18277 Protein denotes TNFSF13B
T13145 18212-18222 Gene_expression denotes expression
T13146 18212-18222 Gene_expression denotes expression
T13147 18212-18222 Gene_expression denotes expression
T13148 18343-18348 Protein denotes NleH1
T13149 18423-18432 Protein denotes RPS3 S209
T13150 18480-18500 Protein denotes RPS3-dependent NF-κB
T13151 18433-18448 Phosphorylation denotes phosphorylation
T13152 18461-18470 Negative_regulation denotes impairing
T13153 18414-18422 Negative_regulation denotes blocking
T14172 18531-18540 Protein denotes RPS3 S209
T14173 18541-18556 Phosphorylation denotes phosphorylation
T14174 18522-18530 Negative_regulation denotes inhibits
T14175 18771-18777 Protein denotes ΔnleH1
T14176 19007-19012 Protein denotes NleH1
T14177 19021-19030 Protein denotes RPS3 S209
T14178 19075-19079 Protein denotes RPS3
T14179 19031-19046 Phosphorylation denotes phosphorylation
T14180 19080-19087 Entity denotes nuclear
T14181 19088-19101 Localization denotes translocation
T14182 19013-19020 Negative_regulation denotes blocked
T14183 19064-19074 Negative_regulation denotes preventing
T14184 19223-19227 Protein denotes RPS3
T14185 19361-19365 Protein denotes RPS3
T14186 19432-19436 Protein denotes RPS3
T14187 19437-19447 Gene_expression denotes expression
T14188 19510-19515 Protein denotes NleH1
T14189 19525-19534 Protein denotes RPS3 S209
T14190 19535-19550 Phosphorylation denotes phosphorylation
T14191 19516-19524 Negative_regulation denotes inhibits
T16750 19647-19652 Protein denotes NleH1
T16751 19664-19668 Protein denotes IKKβ
T16752 19693-19698 Protein denotes NleH1
T16753 19824-19829 Protein denotes NleH1
T16754 19839-19848 Protein denotes RPS3 S209
T16755 19938-19943 Protein denotes NleH1
T16756 20008-20013 Protein denotes NleH1
T16757 20056-20080 Protein denotes NleH1 kinase-dead mutant
T16758 20082-20089 Protein denotes Fig. 7a
T16759 19849-19864 Phosphorylation denotes phosphorylation
T16760 20017-20035 Phosphorylation denotes autophosphorylated
T16761 20017-20035 Phosphorylation denotes autophosphorylated
T16762 20017-20035 Phosphorylation denotes autophosphorylated
T16763 19830-19838 Negative_regulation denotes inhibits
T16764 20147-20152 Protein denotes NleH1
T16765 20164-20168 Protein denotes IKKβ
T16766 20188-20192 Protein denotes RPS3
T16767 20248-20259 Protein denotes K159A NleH1
T16768 20169-20184 Phosphorylation denotes phosphorlyation
T16769 20169-20184 Phosphorylation denotes phosphorlyation
T16770 20217-20227 Gene_expression denotes expressing
T16771 20156-20163 Negative_regulation denotes inhibit
T16772 20156-20163 Negative_regulation denotes inhibit
T16773 20285-20290 Protein denotes NleH1
T16774 20324-20327 Protein denotes TNF
T16775 20336-20345 Protein denotes RPS3 S209
T16776 20405-20412 Protein denotes Fig. 7b
T16777 20291-20301 Gene_expression denotes expression
T16778 20346-20361 Phosphorylation denotes phosphorylation
T16779 20328-20335 Positive_regulation denotes induced
T16780 20316-20323 Negative_regulation denotes reduced
T16781 20420-20432 Protein denotes NleH1 kinase
T16782 20465-20469 Protein denotes RPS3
T16783 20475-20479 Protein denotes IKKβ
T16784 20489-20504 Phosphorylation denotes phosphorylation
T16785 20635-20652 Protein denotes C. rodentium NleH
T16786 20663-20667 Protein denotes RPS3
T16787 20694-20698 Protein denotes RPS3
T16788 20712-20725 Protein denotes κB luciferase
T16789 20770-20775 Protein denotes NleH1
T16790 20668-20675 Entity denotes nuclear
T16791 20676-20689 Localization denotes translocation
T16792 20676-20689 Localization denotes translocation
T16793 20653-20662 Negative_regulation denotes inhibited
T16794 20653-20662 Negative_regulation denotes inhibited
T16795 20797-20806 Protein denotes RPS3 S209
T16796 20807-20822 Phosphorylation denotes phosphorylation
T16797 20904-20907 Protein denotes TNF
T16798 20953-20962 Protein denotes RPS3 S209
T16799 20980-20987 Protein denotes Fig. 7c
T16800 20963-20978 Phosphorylation denotes phosphorylation
T16801 20941-20949 Positive_regulation denotes increase
T16802 21011-21015 Protein denotes RPS3
T16803 21016-21031 Phosphorylation denotes phosphorylation
T16804 20995-21007 Positive_regulation denotes augmentation
T16805 21036-21043 Negative_regulation denotes reduced
T16806 21113-21117 Protein denotes RPS3
T16807 21207-21228 Protein denotes NleH (Fig. 7c, ΔnleH)
T16808 21118-21133 Phosphorylation denotes phosphorylation
T16809 21138-21146 Positive_regulation denotes enhanced
T16810 21199-21206 Negative_regulation denotes lacking
T16811 21262-21274 Protein denotes NleH1 kinase
T16812 21376-21395 Protein denotes K159A E. coli NleH1
T16813 21348-21355 Gene_expression denotes express
T16814 21397-21423 Protein denotes Complementing ΔnleH mutant
T16815 21462-21465 Protein denotes TNF
T16816 21474-21483 Protein denotes RPS3 S209
T16817 21551-21555 Protein denotes RPS3
T16818 21573-21580 Protein denotes Fig. 7c
T16819 21484-21499 Phosphorylation denotes phosphorylation
T16820 21556-21571 Phosphorylation denotes phosphorylation
T16821 21556-21571 Phosphorylation denotes phosphorylation
T16822 21466-21473 Positive_regulation denotes induced
T16823 21543-21550 Negative_regulation denotes inhibit
T16824 21543-21550 Negative_regulation denotes inhibit
T16825 21452-21461 Negative_regulation denotes abolished
T16826 21628-21640 Protein denotes NleH1 kinase
T16827 21671-21675 Protein denotes RPS3
T16828 21676-21680 Protein denotes S209
T16829 21681-21696 Phosphorylation denotes phosphorylation
T16830 21681-21696 Phosphorylation denotes phosphorylation
T16831 21665-21670 Negative_regulation denotes block
T16832 21665-21670 Negative_regulation denotes block
T16833 21750-21755 Protein denotes NleH1
T16834 21825-21829 Protein denotes RPS3
T16835 21867-21871 Protein denotes IKKβ
T16836 21873-21877 Protein denotes IKKβ
T16837 21800-21807 Entity denotes nuclear
T16838 21808-21821 Localization denotes translocation
T16839 21782-21788 Negative_regulation denotes impair
T16840 21954-21972 Protein denotes SSEE IKKβ proteins
T16841 21989-21993 Protein denotes RPS3
T16842 22037-22041 Protein denotes IKKβ
T16843 21923-21933 Gene_expression denotes expressing
T16844 21994-22001 Entity denotes nuclear
T16845 22002-22015 Localization denotes translocation
T16846 22002-22015 Localization denotes translocation
T16847 22068-22072 Protein denotes RPS3
T16848 22073-22080 Entity denotes nuclear
T16849 22081-22093 Localization denotes accumulation
T16850 22264-22268 Protein denotes RPS3
T16851 22301-22314 Protein denotes IKKβ- or IKKβ
T16852 22316-22320 Protein denotes SSEE
T16853 22269-22276 Entity denotes nuclear
T16854 22277-22290 Localization denotes translocation
T16855 22321-22332 Gene_expression denotes -expressing
T16856 22321-22332 Gene_expression denotes -expressing
T16857 22255-22263 Negative_regulation denotes impaired
T16858 22401-22405 Protein denotes RPS3
T16859 22431-22435 Protein denotes IKKβ
T16860 22467-22472 Protein denotes NF-κB
T16861 22406-22413 Entity denotes nuclear
T16862 22414-22427 Localization denotes translocation
T16863 22442-22453 Gene_expression denotes -expressing
T16864 22390-22396 Regulation denotes affect
T16865 22565-22569 Protein denotes RPS3
T16866 22642-22646 Protein denotes IKKβ
T16867 22570-22577 Entity denotes nuclear
T16868 22578-22591 Localization denotes translocation
T16869 22606-22616 Gene_expression denotes expressing
T16870 22557-22564 Negative_regulation denotes inhibit
T16871 22668-22673 Protein denotes NleH1
T16872 22703-22707 Protein denotes IKKβ
T16873 22724-22728 Protein denotes IKKβ
T16874 22738-22742 Protein denotes RPS3
T16875 22743-22747 Protein denotes S209
T16876 22689-22702 Phosphorylation denotes phosphorylate
T16877 22748-22763 Phosphorylation denotes phosphorylation
T16878 22748-22763 Phosphorylation denotes phosphorylation
T16879 22713-22723 Negative_regulation denotes inhibiting
T16880 22713-22723 Negative_regulation denotes inhibiting
T16881 22729-22737 Positive_regulation denotes mediated
T16882 22729-22737 Positive_regulation denotes mediated
T16883 22826-22830 Protein denotes Flag
T16884 22831-22835 Protein denotes IKKβ
T16885 22876-22881 Protein denotes NleH1
T16886 22901-22905 Protein denotes IKKβ
T16887 22906-22925 Phosphorylation denotes autophosphorylation
T16888 22958-22973 Phosphorylation denotes phosphorylation
T16889 22958-22973 Phosphorylation denotes phosphorylation
T16890 23039-23043 Protein denotes IKKβ
T16891 23138-23143 Protein denotes NleH1
T16892 23160-23164 Protein denotes IKKβ
T16893 23250-23253 Protein denotes CK2
T16894 23258-23261 Protein denotes IKK
T16895 23277-23281 Protein denotes IKKβ
T16896 23296-23300 Protein denotes IKKβ
T16897 23316-23320 Protein denotes RPS3
T16898 23322-23325 Protein denotes Fig
T16899 23343-23366 Protein denotes GST-IκBα (1-54) protein
T16900 23368-23371 Protein denotes Fig
T16901 23418-23421 Protein denotes CK2
T16902 23425-23428 Protein denotes IKK
T16903 23301-23315 Phosphorylation denotes phosphorylated
T16904 23301-23315 Phosphorylation denotes phosphorylated
T16905 23301-23315 Phosphorylation denotes phosphorylated
T16906 23301-23315 Phosphorylation denotes phosphorylated
T16907 23469-23473 Protein denotes IKKβ
T16908 23479-23484 Protein denotes NleH1
T16909 23493-23497 Protein denotes IKKβ
T16910 23507-23511 Protein denotes RPS3
T16911 23538-23548 Protein denotes CK2 kinase
T16920 23498-23506 Positive_regulation denotes mediated
T16921 23575-23583 Positive_regulation denotes mediated
T16922 23575-23583 Positive_regulation denotes mediated
T16923 23685-23690 Protein denotes NleH1
T16924 23742-23746 Protein denotes RPS3
T16925 23750-23758 Protein denotes GST-IκBα
T16926 23760-23767 Protein denotes Fig. 7e
T16927 23700-23715 Phosphorylation denotes phosphorylation
T16928 23700-23715 Phosphorylation denotes phosphorylation
T16929 23700-23715 Phosphorylation denotes phosphorylation
T16930 23700-23715 Phosphorylation denotes phosphorylation
T16931 23719-23738 Phosphorylation denotes autophosphorylation
T17276 23719-23738 Phosphorylation denotes autophosphorylation
T17277 23719-23738 Phosphorylation denotes autophosphorylation
T17278 23786-23791 Protein denotes NleH1
T17279 23803-23806 Protein denotes CK2
T17280 23832-23836 Protein denotes IKKβ
T17281 23857-23861 Protein denotes IKKβ
T17282 23871-23880 Protein denotes RPS3 S209
T17283 23881-23896 Phosphorylation denotes phosphorylation
T17284 23842-23852 Negative_regulation denotes inhibiting
T17285 23862-23870 Positive_regulation denotes mediated
T19641 24005-24009 Protein denotes RPS3
T19642 24084-24113 Protein denotes NF-κB regulatory specificity6
T19643 24073-24083 Positive_regulation denotes conferring
T19644 24147-24152 Protein denotes NF-κB
T19645 24183-24187 Protein denotes RPS3
T19646 24222-24227 Protein denotes NF-κB
T19647 24273-24277 Protein denotes IKKβ
T19648 24287-24296 Protein denotes RPS3 S209
T19649 24419-24424 Protein denotes NF-κB
T19650 24297-24312 Phosphorylation denotes phosphorylation
T19651 24364-24371 Entity denotes nuclear
T19652 24278-24286 Positive_regulation denotes mediated
T19653 24449-24453 Protein denotes IKKβ
T19654 24494-24498 Protein denotes IκBs
T19655 24516-24521 Protein denotes NF-κB
T19656 24479-24493 Phosphorylation denotes phosphorylates
T19657 24479-24493 Phosphorylation denotes phosphorylates
T19658 24559-24572 Protein_catabolism denotes degradation40
T19659 24559-24572 Protein_catabolism denotes degradation40
T19660 24586-24590 Protein denotes RPS3
T19661 24710-24720 Protein denotes human IKKβ
T19662 24731-24734 Protein denotes CK2
T19663 24815-24819 Protein denotes IKKβ
T19664 24829-24833 Protein denotes IKKα
T19665 24850-24854 Protein denotes RPS3
T19666 24740-24755 Phosphorylation denotes phosphorylation
T19667 24740-24755 Phosphorylation denotes phosphorylation
T19668 24835-24849 Phosphorylation denotes phosphorylated
T19669 24835-24849 Phosphorylation denotes phosphorylated
T19670 24835-24849 Phosphorylation denotes phosphorylated
T19671 24915-24919 Protein denotes RPS3
T19672 24947-24957 Protein denotes importin-α
T19673 24986-24991 Protein denotes NF-κB
T19674 24920-24927 Entity denotes nuclear
T19675 24928-24941 Localization denotes translocation
T19676 24992-25005 Transcription denotes transcription
T19677 24900-24910 Regulation denotes modulation
T19678 25007-25010 Protein denotes CK2
T19679 25049-25052 Protein denotes p65
T19680 25144-25148 Protein denotes IKKβ
T19681 25155-25158 Protein denotes CK2
T19682 25190-25194 Protein denotes RPS3
T19683 25222-25225 Protein denotes CK2
T19684 25246-25250 Protein denotes IKKβ
T19685 25035-25048 Phosphorylation denotes phosphorylate
T19686 25060-25064 Binding denotes bind
T19687 25149-25154 Binding denotes bound
T19688 25149-25154 Binding denotes bound
T19689 25195-25210 Phosphorylation denotes phosphorylation
T19690 25230-25238 Gene_expression denotes detected
T19691 25165-25172 Positive_regulation denotes account
T19692 25308-25312 Protein denotes RPS3
T19693 25330-25339 Protein denotes CK2 motif
T19694 25378-25382 Protein denotes RPS3
T19695 25421-25424 Protein denotes IKK
T19696 25459-25474 Phosphorylation denotes phosphorylation
T19697 25534-25538 Protein denotes RPS3
T19698 25572-25577 Protein denotes NF-κB
T19699 25687-25691 Protein denotes IKKβ
T19700 25701-25710 Protein denotes RPS3 S209
T19701 25791-25796 Protein denotes NF-κB
T19702 25711-25726 Phosphorylation denotes phosphorylation
T19703 25692-25700 Positive_regulation denotes mediated
T19704 25831-25836 Protein denotes NleH1
T19705 25859-25863 Protein denotes RPS3
T19706 25920-25925 Protein denotes NF-κB
T19707 25850-25855 Binding denotes binds
T19708 25909-25919 Negative_regulation denotes suppresses
T19709 25997-26002 Protein denotes NleH1
T19710 26024-26028 Protein denotes RPS3
T19711 26102-26107 Protein denotes NF-κB
T19712 26141-26146 Protein denotes NF-κB
T19713 26029-26044 Phosphorylation denotes phosphorylation
T19714 26073-26086 Localization denotes translocation
T19715 26073-26086 Localization denotes translocation
T19716 26015-26023 Negative_regulation denotes inhibits
T19717 26167-26180 Protein denotes NleH1 did not
T19718 26204-26208 Protein denotes IKKβ
T19719 26254-26258 Protein denotes IKKβ
T19720 26268-26272 Protein denotes RPS3
T19721 26273-26277 Protein denotes S209
T19722 26190-26203 Phosphorylation denotes phosphorylate
T19723 26190-26203 Phosphorylation denotes phosphorylate
T19724 26278-26293 Phosphorylation denotes phosphorylation
T19725 26278-26293 Phosphorylation denotes phosphorylation
T19726 26246-26253 Negative_regulation denotes inhibit
T19727 26246-26253 Negative_regulation denotes inhibit
T19728 26259-26267 Positive_regulation denotes mediated
T19729 26259-26267 Positive_regulation denotes mediated
T19730 26338-26356 Protein denotes target key kinases
T19731 26424-26429 Protein denotes NleH1
T19732 26468-26472 Protein denotes IKKβ
T19733 26508-26513 Protein denotes NF-κB
T19734 26324-26332 Gene_expression denotes products
T19735 26581-26586 Protein denotes NF-κB
T19736 26739-26744 Protein denotes NleH1
T19737 26777-26781 Protein denotes RPS3
T19738 26806-26811 Protein denotes NF-κB
T19739 26911-26914 Protein denotes IL8
T19740 26919-26922 Protein denotes TNF
T19741 26760-26773 Transcription denotes transcription
T19742 26760-26773 Transcription denotes transcription
T19743 26760-26773 Transcription denotes transcription
T19744 26937-26942 Protein denotes NleH1
T19745 26958-26963 Protein denotes NF-κB
T19746 26964-26967 Protein denotes p65
T19747 27037-27041 Protein denotes RPS3
T19748 27054-27059 Protein denotes NF-κB
T19749 26968-26975 Entity denotes nuclear
T19750 26976-26989 Localization denotes translocation
T19751 26976-26989 Localization denotes translocation
T19752 26952-26957 Negative_regulation denotes block
T19753 26952-26957 Negative_regulation denotes block
T19754 27186-27190 Protein denotes RPS3
T19755 27209-27214 Protein denotes NF-κB
T19756 27229-27234 Protein denotes NleH1
T19757 27175-27185 Negative_regulation denotes inhibiting
T19758 27175-27185 Negative_regulation denotes inhibiting
T19759 27175-27185 Negative_regulation denotes inhibiting
T19760 27793-27798 Protein denotes NF-κB
T19761 27830-27834 Protein denotes RPS3
T19762 27853-27856 Protein denotes p65
T19763 27857-27864 Entity denotes nuclear
T19764 27865-27878 Localization denotes translocation
T19765 27844-27852 Regulation denotes altering
T19766 28080-28085 Protein denotes NF-κB
T19767 28136-28140 Protein denotes RPS3
T19768 28163-28168 Protein denotes NF-κB
T19769 28169-28179 Negative_regulation denotes inhibition
T20471 28423-28426 Protein denotes p65
T20472 28428-28432 Protein denotes C-20
T20473 28587-28653 Protein denotes importin-α (IM-75, I1784), and importin-β (31H4, I2534) antibodies
T20474 28671-28675 Protein denotes PARP
T20475 28795-28824 Protein denotes Hsp90 (68, 610418) antibodies
T20476 28895-28934 Protein denotes phospho-IKKα/β (16A6, 2697S) antibodies
T20477 29075-29100 Protein denotes polyclonal RPS3 antiserum
T20478 29175-29179 Protein denotes S209
T20479 29195-29199 Protein denotes RPS3
T20480 29180-29194 Phosphorylation denotes phosphorylated
T20481 29180-29194 Phosphorylation denotes phosphorylated
T20770 29321-29330 Protein denotes Flag-IKKβ
T20771 29332-29336 Protein denotes SSEE
T20772 29339-29343 Protein denotes Flag
T20773 29344-29348 Protein denotes IKKβ
T20774 29361-29368 Protein denotes HA-IκBα
T20775 29370-29374 Protein denotes SSAA
T20776 29481-29488 Protein denotes HA-IκBα
T20777 29493-29497 Protein denotes IKKβ
T20778 29558-29562 Protein denotes Flag
T20779 29563-29567 Protein denotes RPS3
T20780 29569-29572 Protein denotes GST
T20781 29573-29577 Protein denotes RPS3
T20782 29579-29581 Protein denotes HA
T20783 29582-29586 Protein denotes RPS3
T20784 29588-29590 Protein denotes VN
T20785 29591-29593 Protein denotes HA
T20786 29595-29603 Protein denotes NleH1-HA
T20787 29665-29669 Protein denotes RPS3
T20974 30115-30118 Protein denotes TNF
T20975 30232-30236 Protein denotes RPS3
T21328 30251-30263 Protein denotes Vitro Kinase
T21329 30270-30300 Protein denotes Kinase-active recombinant IKKβ
T21330 30305-30318 Protein denotes IKKα proteins
T21331 30402-30427 Protein denotes glutathione S-transferase
T21332 30429-30432 Protein denotes GST
T21333 30470-30473 Protein denotes GST
T21334 30474-30478 Protein denotes RPS3
T21335 30483-30496 Protein denotes RPS3 proteins
T21336 30762-30767 Protein denotes NleH1
T21521 31002-31005 Protein denotes GST
T21522 31009-31012 Protein denotes GST
T21523 31013-31017 Protein denotes RPS3
T21524 31037-31061 Protein denotes recombinant IKKβ protein
T21525 31328-31335 Protein denotes trypsin
T21691 31430-31434 Protein denotes RNAi
T21692 31439-31451 Gene_expression denotes Transfection
T21693 31439-31451 Positive_regulation denotes Transfection
T21694 31486-31490 Protein denotes IKKα
T21695 31526-31530 Protein denotes IKKβ
T21696 31566-31570 Protein denotes IκBα
T21697 31606-31610 Protein denotes RPS3
T22187 32510-32520 Protein denotes Luciferase
T22188 32542-32552 Protein denotes Luciferase
T22189 32697-32726 Protein denotes firefly luciferase constructs
T22190 32734-32758 Protein denotes Renilla luciferase pTKRL
T22191 32917-32936 Protein denotes Dual-Luciferase Kit
T22192 32938-32945 Protein denotes Promega
T22193 32907-32912 Gene_expression denotes using
T22194 32907-32912 Gene_expression denotes using
T22309 32949-32958 Protein denotes Chromatin
T22310 33102-33110 Protein denotes κB sites
T22311 33114-33117 Protein denotes IL8
T22312 33122-33128 Protein denotes NFKBIA
T22313 33141-33145 Protein denotes ACTB
T22314 33079-33085 Entity denotes region
T22536 33474-33478 Protein denotes RPS3
T23086 33965-33971 Protein denotes mM NaF
T23087 34035-34050 Protein denotes 1 × phosphatase
T23088 34902-34915 Protein denotes serum albumin
T23177 35151-35155 Protein denotes IL-8
T23331 35629-35637 Protein denotes paraffin
T23332 35706-35710 Protein denotes RPS3
T23333 35738-35751 Protein denotes Histoserv Inc
T13036 15812-15816 Protein denotes RPS3
T1676 2932-2939 Entity denotes nuclear
T16912 23570-23574 Protein denotes IKKβ
T16913 23584-23587 Protein denotes GST
T16914 23588-23592 Protein denotes IκBα
T16915 23619-23629 Protein denotes IKK kinase
T16916 23643-23650 Protein denotes Fig. 7e
T16917 23512-23527 Phosphorylation denotes phosphorylation
T16918 23593-23608 Phosphorylation denotes phosphorylation
T16919 23593-23608 Phosphorylation denotes phosphorylation
T11191 13324-13339 Binding denotes complementation
T11192 13324-13339 Binding denotes complementation
T11193 13127-13131 Positive_regulation denotes role
T11194 13127-13131 Positive_regulation denotes role
T11195 13198-13206 Positive_regulation denotes silenced
T11196 13254-13261 Regulation denotes targets
T11197 13254-13261 Regulation denotes targets
T11198 13414-13424 Protein denotes RPS3 siRNA
T11199 13453-13457 Protein denotes RPS3
T11200 13480-13488 Protein denotes NS siRNA
T11201 13534-13538 Protein denotes Flag
T11202 13546-13550 Protein denotes RPS3
R395 T499 T502 themeOf IKKβ,phosphorylation
R396 T500 T504 themeOf RPS3,translocation
R397 T502 T505 causeOf phosphorylation,regulates
R398 T503 T504 locationOf nuclear,translocation
R399 T504 T505 themeOf translocation,regulates
R400 T510 T512 themeOf RPS3,translocation
R401 T511 T512 locationOf nuclear,translocation
R402 T512 T513 themeOf translocation,regulated
R403 T514 T516 themeOf IKKβ,phosphorylation
R404 T515 T518 themeOf RPS3,localization
R405 T516 T519 causeOf phosphorylation,crucial
R406 T517 T518 locationOf nuclear,localization
R407 T518 T519 themeOf localization,crucial
R408 T521 T523 themeOf RPS3 S209,phosphorylation
R409 T522 T524 themeOf RPS3,blocked
R410 T523 T525 themeOf phosphorylation,inhibited
R411 T528 T529 themeOf NF-κB,promotes
R1353 T1676 T1677 locationOf nuclear,translocation
R1354 T1676 T1678 locationOf nuclear,translocation
R1355 T1680 T1684 causeOf coli NleH1 effector,inhibited
R1356 T1681 T1684 themeOf RPS3 S209,inhibited
R1371 T1629 T1632 themeOf RPS3,regulation
R1373 T1630 T1633 themeOf NF-κB,regulation
R1375 T1631 T1634 themeOf immunoglobulin κ light chain gene,expression
R1377 T1635 T1640 themeOf NleH1,secretion
R1378 T1636 T1641 themeOf NF-κB,transcription
R1379 T1637 T1643 themeOf RPS3,translocation
R1382 T1642 T1643 locationOf nuclear,translocation
R1383 T1643 T1644 themeOf translocation,attenuating
R1386 T1646 T1649 themeOf RPS3,translocation
R1387 T1648 T1649 locationOf nuclear,translocation
R1388 T1649 T1650 themeOf translocation,induce
R1391 T1653 T1654 themeOf RPS3,phosphorylated
R1392 T1655 T1658 themeOf NF-κB,regulation
R1393 T1656 T1659 themeOf RPS3,phosphorylated
R1394 T1657 T1660 themeOf NF-κB,activation
R1397 T1662 T1665 themeOf κB (IκB) kinase beta,Inhibitor
R1398 T1662 T1667 partOf κB (IκB) kinase beta,serine
R1399 T1663 T1666 themeOf IKKβ,Inhibitor
R1400 T1663 T1667 partOf IKKβ,serine
R1402 T1664 T1668 themeOf RPS3,phosphorylated
R1403 T1664 T1667 partOf RPS3,serine
R1405 T1667 T1668 Site serine,phosphorylated
R1406 T1669 T1673 themeOf RPS3 S209,phosphorylation
R1407 T1670 T1674 themeOf importin-α,association
R1409 T1671 T1675 themeOf RPS3,mediating
R1410 T1671 T1677 themeOf RPS3,translocation
R1411 T1672 T1678 themeOf karyopherin,translocation
R1412 T1673 T1679 causeOf phosphorylation,enhanced
R1415 T1674 T1679 themeOf association,enhanced
R1893 T2366 T2368 themeOf RPS3,phosphorylation
R1894 T2367 T2369 themeOf NF-κB,activation
R1895 T2368 T2370 themeOf phosphorylation,activation
R1896 T2369 T2371 themeOf activation,response
R1897 T2370 T2372 themeOf activation,response
R1898 T2373 T2378 themeOf RPS3,phosphorylated
R1899 T2374 T2379 themeOf NF-κB,activation
R1900 T2380 T2384 themeOf RPS3,phosphorylated
R1901 T2381 T2385 themeOf TNF,stimulation
R1902 T2382 T2386 themeOf RPS3 protein,increase
R1903 T2383 T2387 themeOf Fig. 1a,increase
R1904 T2388 T2390 themeOf RPS3,phosphorylated
R1905 T2391 T2399 causeOf TNF,stimulated
R1906 T2391 T2400 causeOf TNF,stimulated
R1907 T2392 T2394 themeOf IκBα,phosphorylation
R1908 T2392 T2395 themeOf IκBα,degradaion
R1909 T2393 T2396 themeOf RPS3,phosphorylation
R1910 T2394 T2397 themeOf phosphorylation,stimulated
R1911 T2394 T2399 themeOf phosphorylation,stimulated
R1912 T2395 T2398 themeOf degradaion,stimulated
R1913 T2395 T2400 themeOf degradaion,stimulated
R1914 T2401 T2403 themeOf RPS3,threonine-phosphorylation
R2424 T3050 T3055 themeOf κB kinase,inhibitor
R2425 T3051 T3056 themeOf IKK,inhibitor
R2426 T3052 T3057 themeOf subunit IKKγ,consisting
R2427 T3053 T3058 themeOf IKKα,consisting
R2428 T3054 T3059 themeOf IKKβ,consisting
R2429 T3055 T3060 themeOf inhibitor,activation
R2430 T3056 T3061 themeOf inhibitor,activation
R2431 T3057 T3062 themeOf consisting,inhibitor
R2432 T3058 T3063 themeOf consisting,inhibitor
R2433 T3059 T3064 themeOf consisting,inhibitor
R2434 T3065 T3071 themeOf RPS3,found
R2435 T3068 T3071 themeOf IκBα,found
R2436 T3069 T3072 themeOf IKKβ,activated
R2437 T3069 T3073 themeOf IKKβ,bind
R2438 T3069 T3074 themeOf IKKβ,phosphorylate
R2439 T3070 T3075 themeOf RPS3,phosphorylate
R2440 T3076 T3079 themeOf IKKβ,expressed
R2441 T3076 T3081 themeOf IKKβ,interacted
R2442 T3077 T3080 themeOf RPS3,expressed
R2443 T3077 T3082 themeOf RPS3,interacted
R2444 T3078 T3083 themeOf Fig. 1c,interacted
R2445 T3084 T3087 themeOf IKKβ,interaction
R2446 T3085 T3087 themeOf RPS3,interaction
R2447 T3086 T3088 themeOf NF-κB,transcription
R2448 T3092 T3094 themeOf RPS3,phosphorylation
R2449 T3092 T3093 partOf RPS3,serine
R2450 T3093 T3094 Site serine,phosphorylation
R2451 T3095 T3098 themeOf RPS3,interaction
R2452 T3096 T3098 themeOf IKKα,interaction
R3428 T4274 T4278 causeOf IKKβ,required
R3429 T4275 T4277 themeOf RPS3,translocation
R3430 T4276 T4277 locationOf nuclear,translocation
R3431 T4277 T4278 themeOf translocation,required
R3432 T4279 T4285 themeOf RPS3,interaction
R3433 T4280 T4285 themeOf IKKβ,interaction
R3434 T4281 T4287 themeOf RPS3,translocation
R3435 T4282 T4288 themeOf IKKα,expression
R3436 T4283 T4289 themeOf IKKβ,expression
R3437 T4284 T4291 themeOf RPS3,migration
R3438 T4285 T4292 causeOf interaction,required
R3439 T4286 T4287 locationOf nuclear,translocation
R3440 T4287 T4292 themeOf translocation,required
R3441 T4290 T4291 locationOf nuclear,migration
R3442 T4291 T4293 themeOf migration,stimulation-induced
R3443 T4294 T4298 themeOf TNF,translocation
R3444 T4295 T4299 themeOf PMA+I,translocation
R3445 T4296 T4300 themeOf RPS3,translocation
R3446 T4297 T4298 locationOf nuclear,translocation
R3447 T4297 T4299 locationOf nuclear,translocation
R3448 T4297 T4300 locationOf nuclear,translocation
R3449 T4301 T4304 themeOf RPS3,translocation
R3450 T4302 T4305 themeOf IKKα,silencing
R3451 T4303 T4304 locationOf nuclear,translocation
R3452 T4306 T4309 themeOf IKKβ,knockdown
R3453 T4307 T4311 themeOf RPS3,accumulation
R3454 T4309 T4312 causeOf knockdown,attenuated
R3455 T4310 T4311 locationOf nuclear,accumulation
R3456 T4311 T4312 themeOf accumulation,attenuated
R3457 T4313 T4316 themeOf IKKβ,expression
R3458 T4314 T4317 themeOf IKKα,expression
R3459 T4315 T4319 themeOf RPS3,translocation
R3460 T4318 T4319 locationOf nuclear,translocation
R3461 T4319 T4320 themeOf translocation,activation-induced
R3462 T4321 T4323 themeOf p65,translocation
R3463 T4322 T4323 locationOf nuclear,translocation
R3464 T4323 T4324 themeOf translocation,blocked
R3465 T4325 T4328 themeOf RPS3,translocation
R3466 T4326 T4329 themeOf IKKβ,expressing
R3467 T4327 T4328 locationOf nuclear,translocation
R3468 T4332 T4333 themeOf luciferase,induced
R3469 T4334 T4344 themeOf RPS3,translocated
R3470 T4335 T4339 themeOf IKKβ,-expressing
R3471 T4336 T4340 themeOf RPS3,proportion
R3472 T4337 T4342 themeOf IKKβ,expressing
R3473 T4338 T4343 themeOf SSEE,expressing
R3474 T4341 T4344 locationOf nucleus,translocated
R3475 T4345 T4348 themeOf IKKβ,-expressing
R3476 T4346 T4349 themeOf SSEE,-expressing
R3477 T4347 T4350 themeOf IKKβ,-expressing
R3478 T4350 T4351 themeOf -expressing,increased
R3479 T4353 T4356 themeOf RPS3,translocation
R3480 T4355 T4356 locationOf nuclear,translocation
R3481 T4356 T4357 themeOf translocation,necessary
R5010 T6207 T6209 themeOf IκBα,degradation
R5011 T6208 T6211 themeOf RPS3,translocation
R5012 T6210 T6211 locationOf nuclear,translocation
R5013 T6212 T6216 causeOf Importin-α,regulates
R5014 T6213 T6215 themeOf NF-κB Rel subunits23,import
R5015 T6214 T6215 locationOf nuclear,import
R5016 T6215 T6216 themeOf import,regulates
R5017 T6217 T6221 themeOf RPS3,translocation
R5018 T6218 T6222 themeOf p65,translocation
R5019 T6219 T6223 themeOf translocation6,translocation
R5020 T6220 T6221 locationOf nuclear,translocation
R5021 T6220 T6222 locationOf nuclear,translocation
R5022 T6220 T6223 locationOf nuclear,translocation
R5023 T6226 T6230 themeOf RPS3,association
R5024 T6227 T6230 themeOf importin-α,association
R5025 T6230 T6231 themeOf association,enhanced
R5026 T6232 T6235 themeOf RPS3,binding
R5027 T6233 T6235 themeOf importin-α,binding
R5028 T6237 T6244 themeOf IκBα,degradation
R5029 T6239 T6246 themeOf RPS3,bind
R5030 T6240 T6247 themeOf IκBα,bind
R5031 T6241 T6245 themeOf p65,bind
R5032 T6241 T6246 themeOf p65,bind
R5033 T6241 T6247 themeOf p65,bind
R5034 T6242 T6249 causeOf IκBα degradation is,required
R5035 T6243 T6248 themeOf RPS3,liberation
R5036 T6248 T6249 themeOf liberation,required
R5037 T6250 T6255 themeOf RPS3,association
R5038 T6251 T6256 themeOf wild-type IκBα,overexpressing
R5039 T6252 T6257 themeOf IκBα mutant,overexpressing
R5040 T6252 T6259 themeOf IκBα mutant,phosphorylation
R5041 T6252 T6261 themeOf IκBα mutant,degradation
R5042 T6253 T6258 themeOf SSAA,overexpressing
R5043 T6253 T6260 themeOf SSAA,phosphorylation
R5044 T6253 T6262 themeOf SSAA,degradation
R5045 T6254 T6265 causeOf IKKβ,induced
R5046 T6254 T6266 causeOf IKKβ,induced
R5047 T6259 T6265 themeOf phosphorylation,induced
R5048 T6260 T6266 themeOf phosphorylation,induced
R5049 T6261 T6263 themeOf degradation,resistant
R5050 T6262 T6264 themeOf degradation,resistant
R5051 T6267 T6271 themeOf IκBα,transfected
R5052 T6269 T6273 themeOf RPS3,interaction
R5053 T6271 T6272 themeOf transfected,transfected
R5054 T6273 T6274 themeOf interaction,augmented
R5055 T6295 T6296 themeOf RPS3,augmented
R5056 T6276 T6278 themeOf IκBα,non-degradable
R5057 T6297 T6305 themeOf IκBα,degradation
R5058 T6277 T6279 themeOf Fig. 3b,non-degradable
R5059 T6303 T6307 themeOf RPS3,accumulation
R5060 T6281 T6287 themeOf RPS3,translocation
R5061 T6305 T6308 themeOf degradation,induce
R5062 T6306 T6307 Site nuclear,accumulation
R5063 T6307 T6309 themeOf accumulation,increased
R5064 T6285 T6288 themeOf IκBα,expression
R5065 T6311 T6314 themeOf importin-α,association
R5066 T6312 T6314 themeOf RPS3,association
R5067 T6312 T6315 themeOf RPS3,degradation
R5068 T6313 T6316 themeOf IκBα,degradation
R5069 T6314 T6317 themeOf association,promotes
R5070 T6286 T6287 locationOf nuclear,translocation
R5071 T6287 T6289 themeOf translocation,precluding
R5072 T6288 T6290 themeOf expression,reducing
R5073 T6321 T6324 themeOf IκBα,phosphorylation
R5074 T6321 T6325 themeOf IκBα,degradation
R5075 T6322 T6326 themeOf RPS3,association
R5076 T6323 T6326 themeOf importin-α,association
R5077 T6323 T6328 themeOf importin-α,translocation
R5078 T6292 T6293 themeOf IκBα,depleted
R5079 T6326 T6329 themeOf association,cause
R5080 T6327 T6328 locationOf nuclear,translocation
R5082 T6330 T6332 themeOf IKKβ,phosphorylation
R5083 T6331 T6333 themeOf RPS3,phosphorylation
R8845 T10980 T10982 themeOf RPS3,Phosphorylation
R8851 T10980 T10983 themeOf RPS3,function
R8855 T10981 T10984 themeOf NF-κB,function
R8858 T10985 T10988 themeOf RPS3,translocation
R8863 T10987 T10988 locationOf nuclear,translocation
R8866 T10988 T10989 themeOf translocation,activation
R8867 T10990 T10994 themeOf RPS3,transfected
R8868 T11005 T11006 locationOf nuclear,translocation
R8869 T11005 T11007 locationOf nuclear,translocation
R8870 T11006 T11008 themeOf translocation,attenuated
R8871 T11007 T11009 themeOf translocation,attenuated
R8872 T10995 T10999 themeOf Flag,translocation
R8873 T10996 T11000 themeOf RPS3,translocation
R8874 T11011 T11013 themeOf IKKβ,overexpressing
R8875 T10997 T11001 themeOf Fig. 5a,translocation
R8876 T10998 T10999 locationOf nuclear,translocation
R8877 T10998 T11000 locationOf nuclear,translocation
R8878 T10998 T11001 locationOf nuclear,translocation
R8879 T11002 T11006 themeOf RPS3,translocation
R8880 T11012 T11015 themeOf RPS3,translocation
R8881 T11003 T11007 themeOf S209A,translocation
R8882 T11014 T11015 locationOf nuclear,translocation
R8883 T11016 T11022 themeOf IKKβ,overexpression
R8884 T11019 T11025 themeOf S209A,translocation
R8885 T11020 T11026 themeOf RPS3,translocation
R8887 T11021 T11027 themeOf Fig. 5b,translocation
R8890 T11022 T11023 themeOf overexpression,overexpression
R8893 T11023 T11028 causeOf overexpression,induced
R8894 T11023 T11029 causeOf overexpression,induced
R8896 T11023 T11030 causeOf overexpression,induced
R8898 T11024 T11025 locationOf nuclear,translocation
R8901 T11024 T11026 locationOf nuclear,translocation
R8902 T11024 T11027 locationOf nuclear,translocation
R8904 T11025 T11028 themeOf translocation,induced
R8908 T11026 T11029 themeOf translocation,induced
R8913 T11027 T11030 themeOf translocation,induced
R8914 T11031 T11034 themeOf NF-κB,translocation
R8919 T11032 T11035 themeOf RPS3,translocation
R8920 T11033 T11034 locationOf nuclear,translocation
R8921 T11033 T11035 locationOf nuclear,translocation
R8922 T11034 T11036 themeOf translocation,activation-induced
R8923 T11035 T11037 themeOf translocation,activation-induced
R8924 T11038 T11045 themeOf S209,phosphorylation
R8927 T11039 T11046 themeOf RPS3,phosphorylation
R8932 T11041 T11047 themeOf RPS3,expression
R8939 T11042 T11196 themeOf RPS3 mRNA,targets
R8941 T11042 T11197 themeOf RPS3 mRNA,targets
R8943 T11043 T11191 themeOf S209A mutant,complementation
R8947 T11044 T11192 themeOf RPS3,complementation
R8949 T11045 T11193 themeOf phosphorylation,role
R8952 T11046 T11194 themeOf phosphorylation,role
R8955 T11047 T11195 themeOf expression,silenced
R9004 T11191 T11196 causeOf complementation,targets
R9008 T11192 T11197 causeOf complementation,targets
R9010 T11198 T11203 causeOf RPS3 siRNA,reduced
R9016 T11198 T11205 causeOf RPS3 siRNA,affect
R9018 T11200 T11203 themeOf NS siRNA,reduced
R9019 T11202 T11204 themeOf RPS3,expression
R9022 T11204 T11205 themeOf expression,affect
R9030 T11206 T11212 themeOf RPS3,knockdown
R9034 T11207 T11216 causeOf TNF,induced
R9035 T11207 T11217 causeOf TNF,induced
R9036 T11207 T11218 causeOf TNF,induced
R9037 T11209 T11213 themeOf luciferase construct6,expression
R9038 T11210 T11214 themeOf Fig,expression
R9039 T11255 T11261 themeOf RPS3,knockdown
R9040 T11211 T11215 themeOf 5d,expression
R9041 T11256 T11262 themeOf S209A RPS3,stimulated
R9042 T11257 T11262 causeOf κB sites,stimulated
R9043 T11257 T11263 causeOf κB sites,stimulated
R9044 T11212 T11219 causeOf knockdown,reduced
R9045 T11212 T11220 causeOf knockdown,reduced
R9046 T11260 T11263 themeOf Fig,stimulated
R9047 T11212 T11221 causeOf knockdown,reduced
R9048 T11213 T11216 themeOf expression,induced
R9049 T11214 T11217 themeOf expression,induced
R9050 T11215 T11218 themeOf expression,induced
R9051 T11216 T11219 themeOf induced,reduced
R9052 T11217 T11220 themeOf induced,reduced
R9053 T11264 T11266 themeOf RPS3 S209A,expressing
R9054 T11264 T11267 causeOf RPS3 S209A,impact
R9055 T11264 T11269 themeOf RPS3 S209A,translocation
R9056 T11264 T11271 causeOf RPS3 S209A,impact
R9057 T11264 T11272 causeOf RPS3 S209A,impact
R9058 T11218 T11221 themeOf induced,reduced
R9059 T11265 T11270 themeOf p65,translocation
R9060 T11266 T11267 themeOf expressing,impact
R9061 T11223 T11228 themeOf RPS3,deficiency
R9062 T11268 T11269 locationOf nuclear,translocation
R9063 T11268 T11270 locationOf nuclear,translocation
R9064 T11269 T11271 themeOf translocation,impact
R9065 T11270 T11272 themeOf translocation,impact
R9066 T11273 T11278 themeOf p65,attraction
R9067 T11275 T11277 partOf NF-κB,promoters
R9068 T11227 T11229 themeOf Fig. 5c,expression
R9069 T11276 T11277 partOf CD25,promoters
R9070 T11277 T11278 Site promoters,attraction
R9071 T11278 T11279 themeOf attraction,increased
R9072 T11230 T11235 causeOf RPS3,restore
R9073 T11284 T11287 themeOf κB sites,lacking
R9074 T11231 T11235 themeOf luciferase,restore
R9075 T11288 T11291 themeOf RPS3,recruitment
R9076 T11288 T11292 themeOf RPS3,recruitment
R9077 T11289 T11292 themeOf p65,recruitment
R9078 T11232 T11236 themeOf green fluorescent protein,overexpression
R9079 T11233 T11237 themeOf GFP,overexpression
R9080 T11234 T11240 themeOf RPS3,complemented
R9081 T11236 T11238 themeOf overexpression,overexpression
R9082 T11299 T11301 themeOf CD25,expression
R9083 T11236 T11241 themeOf overexpression,result
R9084 T11302 T11306 themeOf RPS3 S209,phosphorylation
R9085 T11303 T11307 themeOf IKKβ,phosphorylation
R9086 T11304 T11308 causeOf RPS3,required
R9087 T11304 T11309 causeOf RPS3,required
R9088 T11305 T11310 themeOf NF-κB,directing
R9089 T11237 T11239 themeOf overexpression,overexpression
R9090 T11306 T11308 themeOf phosphorylation,required
R9091 T11307 T11309 themeOf phosphorylation,required
R9092 T11237 T11242 themeOf overexpression,result
R9093 T11243 T11246 themeOf RPS3 S209,phosphorylation
R9094 T11248 T11252 themeOf p65 recruitment,phosphorylation
R9095 T11250 T11253 themeOf NF-κB,activation
R9096 T11251 T11252 Site S209,phosphorylation
R9097 T11252 T11254 causeOf phosphorylation,affects
R9098 T11253 T11254 themeOf activation,affects
R10541 T13036 T13037 themeOf RPS3,phosphorylation
R10542 T13037 T13038 themeOf phosphorylation,inhibits
R10543 T13041 T13047 themeOf E. coli O157,binds
R10544 T13042 T13048 themeOf H7 EDL933,binds
R10545 T13043 T13049 themeOf NleH1,binds
R10546 T13044 T13051 themeOf RPS3,translocation
R10547 T13045 T13052 causeOf RPS3,dependent
R10548 T13046 T13052 themeOf NF-κB signaling9,dependent
R10549 T13050 T13051 locationOf nuclear,translocation
R10550 T13052 T13053 themeOf dependent,impairing
R10551 T13054 T13057 causeOf NleH1,inhibiting
R10552 T13055 T13056 themeOf RPS3 S209,phosphorylation
R10553 T13056 T13057 themeOf phosphorylation,inhibiting
R10554 T13061 T13067 causeOf NleH1,reduced
R10555 T13062 T13066 causeOf TNF,induced
R10556 T13063 T13065 themeOf RPS3,phosphorylation
R10557 T13065 T13066 themeOf phosphorylation,induced
R10558 T13066 T13067 themeOf induced,reduced
R10559 T13068 T13075 themeOf NleH1,Expressing
R10560 T13071 T13076 themeOf IκBα,degradation
R10561 T13072 T13077 themeOf NleH1,lack
R10562 T13073 T13078 themeOf p65 nuclear translocation9,lack
R10563 T13074 T13079 themeOf Fig. 6c,lack
R10564 T13080 T13088 causeOf NleH1,inhibits
R10565 T13081 T13085 themeOf RPS3,phosphorylation
R10566 T13082 T13086 themeOf nleH1,lacking
R10567 T13083 T13087 themeOf ΔnleH1,lacking
R10568 T13085 T13088 themeOf phosphorylation,inhibits
R10569 T13090 T13091 themeOf RPS3 S209,phosphorylation
R10570 T13091 T13092 themeOf phosphorylation,increase
R10571 T13093 T13094 themeOf RPS3 S209,phosphorylation
R10572 T13094 T13095 themeOf phosphorylation,impaired
R10573 T13096 T13101 causeOf TNF,induced
R10574 T13097 T13100 themeOf RPS3 S209,phosphorylation
R10575 T13100 T13101 themeOf phosphorylation,induced
R10576 T13101 T13102 themeOf induced,unimpaired
R10577 T13103 T13110 causeOf ΔnleH1,attenuated
R10578 T13104 T13111 causeOf ΔescN E. coli O157:H7,attenuated
R10579 T13105 T13109 causeOf TNF,induced
R10580 T13106 T13108 themeOf RPS3,translocation9
R10581 T13107 T13108 locationOf nuclear,translocation9
R10582 T13108 T13109 themeOf translocation9,induced
R10583 T13109 T13110 themeOf induced,attenuated
R10584 T13109 T13111 themeOf induced,attenuated
R10585 T13112 T13115 themeOf RPS3,phosphorylation
R10586 T13112 T13117 themeOf RPS3,translocation
R10587 T13114 T13118 themeOf RPS3 S209,phosphorylation
R10588 T13116 T13117 locationOf nuclear,translocation
R10589 T13120 T13132 causeOf NleH1,inhibits
R10590 T13121 T13127 themeOf RPS3 S209,phosphorylation
R10591 T13122 T13137 causeOf RPS3,dependent
R10592 T13122 T13138 causeOf RPS3,dependent
R10593 T13122 T13139 causeOf RPS3,dependent
R10594 T13122 T13140 causeOf RPS3,dependent
R10595 T13123 T13128 themeOf NF-κB,transcription
R10596 T13124 T13129 themeOf IL8,transcription
R10597 T13125 T13130 themeOf NFKBIA,transcription
R10598 T13126 T13131 themeOf TNFAIP3,transcription
R10599 T13127 T13132 themeOf phosphorylation,inhibits
R10600 T13128 T13133 themeOf transcription,blocks
R10601 T13128 T13137 themeOf transcription,dependent
R10602 T13129 T13134 themeOf transcription,blocks
R10603 T13129 T13138 themeOf transcription,dependent
R10604 T13130 T13135 themeOf transcription,blocks
R10605 T13130 T13139 themeOf transcription,dependent
R10606 T13131 T13136 themeOf transcription,blocks
R10607 T13131 T13140 themeOf transcription,dependent
R10608 T13142 T13145 themeOf RPS3,expression
R10609 T13143 T13146 themeOf CD25,expression
R10610 T13144 T13147 themeOf TNFSF13B,expression
R10611 T13148 T13152 causeOf NleH1,impairing
R10612 T13149 T13151 themeOf RPS3 S209,phosphorylation
R10613 T13150 T13152 themeOf RPS3-dependent NF-κB,impairing
R10614 T13151 T13153 themeOf phosphorylation,blocking
R11410 T14172 T14173 themeOf RPS3 S209,phosphorylation
R11411 T14173 T14174 themeOf phosphorylation,inhibits
R11412 T14176 T14182 causeOf NleH1,blocked
R11413 T14177 T14179 themeOf RPS3 S209,phosphorylation
R11414 T14178 T14181 themeOf RPS3,translocation
R11415 T14179 T14182 themeOf phosphorylation,blocked
R11416 T14180 T14181 locationOf nuclear,translocation
R11417 T14181 T14183 themeOf translocation,preventing
R11418 T14186 T14187 themeOf RPS3,expression
R11419 T14188 T14191 causeOf NleH1,inhibits
R11420 T14189 T14190 themeOf RPS3 S209,phosphorylation
R11421 T14190 T14191 themeOf phosphorylation,inhibits
R13508 T16753 T16763 causeOf NleH1,inhibits
R13509 T16754 T16759 themeOf RPS3 S209,phosphorylation
R13510 T16756 T16760 themeOf NleH1,autophosphorylated
R13511 T16757 T16761 themeOf NleH1 kinase-dead mutant,autophosphorylated
R13512 T16758 T16762 themeOf Fig. 7a,autophosphorylated
R13513 T16759 T16763 themeOf phosphorylation,inhibits
R13514 T16764 T16771 causeOf NleH1,inhibit
R13515 T16764 T16772 causeOf NleH1,inhibit
R13516 T16765 T16768 themeOf IKKβ,phosphorlyation
R13517 T16766 T16769 themeOf RPS3,phosphorlyation
R13518 T16767 T16770 themeOf K159A NleH1,expressing
R13519 T16768 T16771 themeOf phosphorlyation,inhibit
R13520 T16769 T16772 themeOf phosphorlyation,inhibit
R13521 T16773 T16777 themeOf NleH1,expression
R13522 T16774 T16779 causeOf TNF,induced
R13523 T16775 T16778 themeOf RPS3 S209,phosphorylation
R13524 T16777 T16780 causeOf expression,reduced
R13525 T16778 T16779 themeOf phosphorylation,induced
R13526 T16779 T16780 themeOf induced,reduced
R13527 T16783 T16784 themeOf IKKβ,phosphorylation
R13528 T16786 T16791 themeOf RPS3,translocation
R13529 T16788 T16792 themeOf κB luciferase,translocation
R13530 T16790 T16791 locationOf nuclear,translocation
R13531 T16790 T16792 locationOf nuclear,translocation
R13532 T16791 T16793 themeOf translocation,inhibited
R13533 T16792 T16794 themeOf translocation,inhibited
R13534 T16795 T16796 themeOf RPS3 S209,phosphorylation
R13535 T16798 T16800 themeOf RPS3 S209,phosphorylation
R13536 T16800 T16801 themeOf phosphorylation,increase
R13537 T16802 T16803 themeOf RPS3,phosphorylation
R13538 T16803 T16804 themeOf phosphorylation,augmentation
R13539 T16804 T16805 themeOf augmentation,reduced
R13540 T16806 T16808 themeOf RPS3,phosphorylation
R13541 T16807 T16810 themeOf "NleH (Fig. 7c, ΔnleH)",lacking
R13542 T16808 T16809 themeOf phosphorylation,enhanced
R13543 T16812 T16813 themeOf K159A E. coli NleH1,express
R13544 T16814 T16825 causeOf Complementing ΔnleH mutant,abolished
R13545 T16815 T16822 causeOf TNF,induced
R13546 T16816 T16819 themeOf RPS3 S209,phosphorylation
R13547 T16817 T16820 themeOf RPS3,phosphorylation
R13548 T16818 T16821 themeOf Fig. 7c,phosphorylation
R13549 T16819 T16822 themeOf phosphorylation,induced
R13550 T16820 T16823 themeOf phosphorylation,inhibit
R13551 T16821 T16824 themeOf phosphorylation,inhibit
R13552 T16822 T16825 themeOf induced,abolished
R13553 T16827 T16829 themeOf RPS3,phosphorylation
R13554 T16828 T16830 themeOf S209,phosphorylation
R13555 T16829 T16831 themeOf phosphorylation,block
R13556 T16830 T16832 themeOf phosphorylation,block
R13557 T16834 T16838 themeOf RPS3,translocation
R13558 T16837 T16838 locationOf nuclear,translocation
R13559 T16838 T16839 themeOf translocation,impair
R13560 T16840 T16843 themeOf SSEE IKKβ proteins,expressing
R13561 T16841 T16845 themeOf RPS3,translocation
R13562 T16842 T16846 themeOf IKKβ,translocation
R13563 T16844 T16845 locationOf nuclear,translocation
R13564 T16844 T16846 locationOf nuclear,translocation
R13565 T16847 T16849 themeOf RPS3,accumulation
R13566 T16848 T16849 locationOf nuclear,accumulation
R13567 T16850 T16854 themeOf RPS3,translocation
R13568 T16851 T16855 themeOf IKKβ- or IKKβ,-expressing
R13569 T16852 T16856 themeOf SSEE,-expressing
R13570 T16853 T16854 locationOf nuclear,translocation
R13571 T16854 T16857 themeOf translocation,impaired
R13572 T16858 T16862 themeOf RPS3,translocation
R13573 T16859 T16863 themeOf IKKβ,-expressing
R13574 T16861 T16862 locationOf nuclear,translocation
R13575 T16862 T16864 themeOf translocation,affect
R13576 T16865 T16868 themeOf RPS3,translocation
R13577 T16866 T16869 themeOf IKKβ,expressing
R13578 T16867 T16868 locationOf nuclear,translocation
R13579 T16868 T16870 themeOf translocation,inhibit
R13580 T16871 T16876 themeOf NleH1,phosphorylate
R13581 T16873 T16881 causeOf IKKβ,mediated
R13582 T16873 T16882 causeOf IKKβ,mediated
R13583 T16874 T16877 themeOf RPS3,phosphorylation
R13584 T16875 T16878 themeOf S209,phosphorylation
R13585 T16877 T16879 themeOf phosphorylation,inhibiting
R13586 T16877 T16881 themeOf phosphorylation,mediated
R13587 T16878 T16880 themeOf phosphorylation,inhibiting
R13588 T16878 T16882 themeOf phosphorylation,mediated
R13589 T16883 T16888 themeOf Flag,phosphorylation
R13590 T16886 T16887 themeOf IKKβ,autophosphorylation
R13591 T16886 T16889 themeOf IKKβ,phosphorylation
R13592 T16897 T16903 themeOf RPS3,phosphorylated
R13593 T16898 T16904 themeOf Fig,phosphorylated
R13594 T16899 T16905 themeOf GST-IκBα (1-54) protein,phosphorylated
R13595 T16900 T16906 themeOf Fig,phosphorylated
R13596 T16909 T16920 causeOf IKKβ,mediated
R13597 T16910 T16917 themeOf RPS3,phosphorylation
R13598 T16912 T16921 causeOf IKKβ,mediated
R13599 T16912 T16922 causeOf IKKβ,mediated
R13600 T16913 T16918 themeOf GST,phosphorylation
R13601 T16914 T16919 themeOf IκBα,phosphorylation
R13602 T16917 T16920 themeOf phosphorylation,mediated
R13603 T16918 T16921 themeOf phosphorylation,mediated
R13604 T16919 T16922 themeOf phosphorylation,mediated
R13605 T16923 T16927 themeOf NleH1,phosphorylation
R13606 T16924 T16928 themeOf RPS3,phosphorylation
R13607 T16924 T16931 themeOf RPS3,autophosphorylation
R13608 T16925 T16929 themeOf GST-IκBα,phosphorylation
R13609 T16925 T17276 themeOf GST-IκBα,autophosphorylation
R13610 T16926 T16930 themeOf Fig. 7e,phosphorylation
R13611 T16926 T17277 themeOf Fig. 7e,autophosphorylation
R13785 T17281 T17285 causeOf IKKβ,mediated
R13795 T17282 T17283 themeOf RPS3 S209,phosphorylation
R13799 T17283 T17284 themeOf phosphorylation,inhibiting
R13802 T17283 T17285 themeOf phosphorylation,mediated
R15765 T19642 T19643 themeOf NF-κB regulatory specificity6,conferring
R15766 T19647 T19652 causeOf IKKβ,mediated
R15767 T19648 T19650 themeOf RPS3 S209,phosphorylation
R15768 T19650 T19652 themeOf phosphorylation,mediated
R15769 T19653 T19656 themeOf IKKβ,phosphorylates
R15770 T19653 T19658 themeOf IKKβ,degradation40
R15771 T19654 T19657 themeOf IκBs,phosphorylates
R15772 T19654 T19659 themeOf IκBs,degradation40
R15773 T19661 T19666 themeOf human IKKβ,phosphorylation
R15774 T19662 T19667 themeOf CK2,phosphorylation
R15775 T19663 T19668 themeOf IKKβ,phosphorylated
R15776 T19664 T19669 themeOf IKKα,phosphorylated
R15777 T19665 T19670 themeOf RPS3,phosphorylated
R15778 T19671 T19675 themeOf RPS3,translocation
R15779 T19673 T19676 themeOf NF-κB,transcription
R15780 T19674 T19675 locationOf nuclear,translocation
R15781 T19675 T19677 themeOf translocation,modulation
R15782 T19678 T19686 themeOf CK2,bind
R15783 T19679 T19685 themeOf p65,phosphorylate
R15784 T19680 T19687 themeOf IKKβ,bound
R15785 T19680 T19688 themeOf IKKβ,bound
R15786 T19681 T19688 themeOf CK2,bound
R15787 T19681 T19691 causeOf CK2,account
R15788 T19682 T19689 themeOf RPS3,phosphorylation
R15789 T19683 T19690 themeOf CK2,detected
R15790 T19689 T19691 themeOf phosphorylation,account
R15791 T19695 T19696 themeOf IKK,phosphorylation
R15792 T19699 T19703 causeOf IKKβ,mediated
R15793 T19700 T19702 themeOf RPS3 S209,phosphorylation
R15794 T19702 T19703 themeOf phosphorylation,mediated
R15795 T19704 T19707 themeOf NleH1,binds
R15796 T19704 T19708 causeOf NleH1,suppresses
R15797 T19705 T19707 themeOf RPS3,binds
R15798 T19706 T19708 themeOf NF-κB,suppresses
R15799 T19709 T19716 causeOf NleH1,inhibits
R15800 T19710 T19713 themeOf RPS3,phosphorylation
R15801 T19710 T19714 themeOf RPS3,translocation
R15802 T19711 T19715 themeOf NF-κB,translocation
R15803 T19713 T19716 themeOf phosphorylation,inhibits
R15804 T19717 T19722 themeOf NleH1 did not,phosphorylate
R15805 T19718 T19723 themeOf IKKβ,phosphorylate
R15806 T19719 T19728 causeOf IKKβ,mediated
R15807 T19719 T19729 causeOf IKKβ,mediated
R15808 T19720 T19724 themeOf RPS3,phosphorylation
R15809 T19721 T19725 themeOf S209,phosphorylation
R15810 T19724 T19726 themeOf phosphorylation,inhibit
R15811 T19724 T19728 themeOf phosphorylation,mediated
R15812 T19725 T19727 themeOf phosphorylation,inhibit
R15813 T19725 T19729 themeOf phosphorylation,mediated
R15814 T19730 T19734 themeOf target key kinases,products
R15815 T19736 T19741 themeOf NleH1,transcription
R15816 T19737 T19742 themeOf RPS3,transcription
R15817 T19738 T19743 themeOf NF-κB,transcription
R15818 T19744 T19752 causeOf NleH1,block
R15819 T19744 T19753 causeOf NleH1,block
R15820 T19745 T19750 themeOf NF-κB,translocation
R15821 T19746 T19751 themeOf p65,translocation
R15822 T19749 T19750 locationOf nuclear,translocation
R15823 T19749 T19751 locationOf nuclear,translocation
R15824 T19750 T19752 themeOf translocation,block
R15825 T19751 T19753 themeOf translocation,block
R15826 T19754 T19757 themeOf RPS3,inhibiting
R15827 T19755 T19758 themeOf NF-κB,inhibiting
R15828 T19756 T19759 themeOf NleH1,inhibiting
R15829 T19762 T19764 themeOf p65,translocation
R15830 T19763 T19764 locationOf nuclear,translocation
R15831 T19764 T19765 themeOf translocation,altering
R15832 T19768 T19769 themeOf NF-κB,inhibition
R16344 T20478 T20480 themeOf S209,phosphorylated
R16345 T20479 T20481 themeOf RPS3,phosphorylated
R17252 T21691 T21692 themeOf RNAi,Transfection
R17253 T21692 T21693 themeOf Transfection,Transfection
R17697 T22191 T22193 themeOf Dual-Luciferase Kit,using
R17698 T22192 T22194 themeOf Promega,using
R17774 T22310 T22314 partOf κB sites,region
R17775 T22311 T22314 partOf IL8,region
R17776 T22312 T22314 partOf NFKBIA,region
R17777 T22313 T22314 partOf ACTB,region

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T62 0-4 Protein denotes IKKβ
T63 5-20 Phosphorylation denotes phosphorylation
T64 21-30 Regulation denotes regulates
T65 31-35 Protein denotes RPS3
T66 36-43 Entity denotes nuclear
T67 44-57 Localization denotes translocation
T68 186-206 Protein denotes ribosomal protein S3
T69 208-212 Protein denotes RPS3
T70 303-307 Protein denotes RPS3
T71 308-315 Entity denotes nuclear
T72 316-329 Localization denotes translocation
T73 333-342 Regulation denotes regulated true
T74 364-368 Protein denotes IKKβ
T75 369-384 Phosphorylation denotes phosphorylation
T76 388-398 Entity denotes serine 209
T77 410-417 Positive_regulation denotes crucial
T78 422-426 Protein denotes RPS3
T79 427-434 Entity denotes nuclear
T80 435-447 Localization denotes localization
T81 448-462 Positive_regulation denotes in response to
T82 463-473 Positive_regulation denotes activating
T83 559-564 Protein denotes NleH1
T84 578-587 Negative_regulation denotes inhibited
T85 588-592 Protein denotes RPS3
T86 593-597 Entity denotes S209
T87 598-613 Phosphorylation denotes phosphorylation
T88 618-625 Negative_regulation denotes blocked
T89 626-630 Protein denotes RPS3
T90 771-775 Protein denotes IKKβ
T91 776-785 Regulation denotes dependent
T92 786-798 Protein_modification denotes modification
T93 827-831 Protein denotes RPS3
T729 1203-1207 Protein denotes RelA
T730 1209-1212 Protein denotes p65
T731 1215-1219 Protein denotes RelB
T732 1221-1226 Protein denotes c-Rel
T733 1228-1231 Protein denotes p50
T734 1237-1240 Protein denotes p52
T735 1294-1314 Protein denotes ribosomal protein S3
T736 1316-1320 Protein denotes RPS3
T737 1335-1338 Protein denotes Rel
T738 1383-1387 Protein denotes RPS3
T739 1564-1568 Protein denotes RPS3
T740 1636-1664 Protein denotes immunoglobulin κ light chain
T741 1670-1680 Gene_expression denotes expression
T742 1908-1913 Protein denotes NleH1
T743 1968-1979 Negative_regulation denotes attenuating
T744 1980-1984 Protein denotes RPS3
T745 1985-1992 Entity denotes nuclear
T746 1993-2006 Localization denotes translocation
T747 2016-2025 Regulation denotes affecting true
T748 2026-2029 Protein denotes p65
T749 2030-2042 Localization denotes localization
T750 2096-2102 Positive_regulation denotes induce true
T751 2103-2107 Protein denotes RPS3
T752 2108-2115 Entity denotes nuclear
T753 2116-2129 Localization denotes translocation
T754 2220-2227 Binding denotes binding
T755 2266-2270 Protein denotes RPS3
T756 2353-2357 Protein denotes RPS3
T757 2361-2375 Phosphorylation denotes phosphorylated true
T758 2487-2491 Protein denotes RPS3
T759 2495-2509 Phosphorylation denotes phosphorylated true
T760 2672-2676 Protein denotes RPS3
T761 2727-2760 Protein denotes Inhibitor of κB (IκB) kinase beta
T762 2762-2766 Protein denotes IKKβ
T763 2768-2782 Phosphorylation denotes phosphorylated
T764 2783-2787 Protein denotes RPS3
T765 2791-2801 Entity denotes serine 209
T766 2810-2814 Protein denotes RPS3
T767 2815-2819 Entity denotes S209
T768 2820-2835 Phosphorylation denotes phosphorylation
T769 2836-2844 Positive_regulation denotes enhanced
T770 2849-2860 Binding denotes association
T771 2878-2887 Positive_regulation denotes mediating
T772 2888-2892 Protein denotes RPS3
T773 2932-2939 Entity denotes nuclear
T774 2940-2953 Localization denotes translocation
T775 2980-2985 Protein denotes NleH1
T776 3008-3017 Negative_regulation denotes inhibited
T777 3018-3022 Protein denotes RPS3
T778 3023-3027 Entity denotes S209
T1983 3126-3130 Protein denotes RPS3
T1984 3131-3146 Phosphorylation denotes phosphorylation
T1985 3147-3161 Positive_regulation denotes in response to true
T1986 3195-3199 Protein denotes RPS3
T1987 3203-3217 Phosphorylation denotes phosphorylated true
T1988 3345-3349 Protein denotes RPS3
T1989 3363-3377 Phosphorylation denotes phosphorylated true
T1990 3422-3430 Positive_regulation denotes increase
T1991 3434-3451 Phosphorylation denotes 32P-incorporation
T1992 3485-3493 Positive_regulation denotes increase true
T1993 3497-3501 Protein denotes RPS3
T1994 3540-3544 Protein denotes RPS3
T1995 3545-3553 Entity denotes residues
T1996 3559-3573 Phosphorylation denotes phosphorylated true
T1997 3597-3601 Protein denotes RPS3
T1998 3770-3780 Positive_regulation denotes stimulated
T1999 3770-3780 Positive_regulation denotes stimulated
T2000 3787-3802 Phosphorylation denotes phosphorylation
T2001 3807-3817 Protein_catabolism denotes degradaion
T2002 3821-3825 Protein denotes IκBα
T2003 3864-3868 Protein denotes RPS3
T2004 3869-3884 Phosphorylation denotes phosphorylation
T2005 3888-3903 Entity denotes serine residues
T2006 3985-3993 Entity denotes tyrosine
T2007 3998-4007 Entity denotes threonine
T2008 4008-4023 Phosphorylation denotes phosphorylation true
T2009 4008-4023 Phosphorylation denotes phosphorylation true
T2010 4027-4031 Protein denotes RPS3
T2601 4044-4048 Protein denotes RPS3
T2602 4053-4057 Protein denotes IKKβ
T2603 4058-4069 Binding denotes interaction true
T2604 4157-4161 Protein denotes IKKγ
T2605 4190-4194 Protein denotes IKKα
T2606 4199-4203 Protein denotes IKKβ
T2607 4322-4326 Protein denotes RPS3
T2608 4359-4362 Protein denotes p65
T2609 4363-4366 Protein denotes p50
T2610 4367-4371 Protein denotes IκBα
T2611 4431-4440 Positive_regulation denotes activated
T2612 4441-4445 Protein denotes IKKβ
T2613 4457-4461 Binding denotes bind true
T2614 4469-4482 Phosphorylation denotes phosphorylate true
T2615 4483-4487 Protein denotes RPS3
T2616 4522-4531 Gene_expression denotes expressed
T2617 4532-4536 Protein denotes IKKβ
T2618 4541-4545 Protein denotes RPS3
T2619 4546-4556 Binding denotes interacted
T2620 4639-4643 Protein denotes IKKβ
T2621 4644-4648 Protein denotes RPS3
T2622 4649-4660 Binding denotes interaction
T2623 4775-4779 Protein denotes RPS3
T2624 4780-4784 Protein denotes IKKβ
T2625 4785-4796 Binding denotes association
T2626 4809-4818 Positive_regulation denotes augmented
T2627 4871-4880 Positive_regulation denotes following
T2628 4901-4905 Protein denotes RPS3
T2629 4906-4912 Entity denotes serine
T2630 4913-4928 Phosphorylation denotes phosphorylation
T2631 4977-4988 Binding denotes interaction true
T2632 4997-5001 Protein denotes RPS3
T2633 5006-5010 Protein denotes IKKα
T3438 5023-5027 Protein denotes IKKβ
T3439 5031-5039 Positive_regulation denotes required
T3440 5044-5048 Protein denotes RPS3
T3441 5049-5056 Entity denotes nuclear
T3442 5057-5070 Localization denotes translocation
T3443 5094-5098 Protein denotes RPS3
T3444 5099-5103 Protein denotes IKKβ
T3445 5104-5115 Binding denotes interaction
T3446 5119-5127 Positive_regulation denotes required true
T3447 5132-5136 Protein denotes RPS3
T3448 5137-5144 Entity denotes nuclear
T3449 5145-5158 Localization denotes translocation
T3450 5163-5175 Negative_regulation denotes knocked down
T3451 5163-5175 Negative_regulation denotes knocked down
T3452 5176-5180 Protein denotes IKKα
T3453 5184-5188 Protein denotes IKKβ
T3454 5189-5199 Gene_expression denotes expression
T3455 5189-5199 Gene_expression denotes expression
T3456 5265-5272 Positive_regulation denotes induced true
T3457 5273-5277 Protein denotes RPS3
T3458 5278-5285 Entity denotes nuclear
T3459 5286-5295 Localization denotes migration
T3460 5339-5348 Positive_regulation denotes triggered
T3461 5349-5353 Protein denotes RPS3
T3462 5354-5361 Entity denotes nuclear
T3463 5362-5375 Localization denotes translocation
T3464 5456-5460 Protein denotes RPS3
T3465 5461-5468 Entity denotes nuclear
T3466 5469-5482 Localization denotes translocation
T3467 5513-5521 Negative_regulation denotes impaired
T3468 5525-5529 Protein denotes IKKα
T3469 5530-5539 Negative_regulation denotes silencing
T3470 5553-5562 Negative_regulation denotes knockdown
T3471 5566-5570 Protein denotes IKKβ
T3472 5571-5581 Negative_regulation denotes attenuated
T3473 5592-5596 Protein denotes RPS3
T3474 5597-5604 Entity denotes nuclear
T3475 5605-5617 Localization denotes accumulation
T3476 5618-5627 Positive_regulation denotes following
T3477 5707-5717 Gene_expression denotes expression
T3478 5707-5717 Gene_expression denotes expression
T3479 5721-5725 Protein denotes IKKβ
T3480 5735-5739 Protein denotes IKKα
T3481 5745-5754 Positive_regulation denotes necessary true
T3482 5745-5754 Positive_regulation denotes necessary true
T3483 5770-5777 Positive_regulation denotes induced
T3484 5778-5782 Protein denotes RPS3
T3485 5783-5790 Entity denotes nuclear
T3486 5791-5804 Localization denotes translocation
T3487 5850-5853 Protein denotes p65
T3488 5854-5861 Entity denotes nuclear
T3489 5862-5875 Localization denotes translocation
T3490 5880-5887 Negative_regulation denotes blocked
T3491 5946-5953 Entity denotes nuclear
T3492 5954-5967 Localization denotes translocation true
T3493 5971-5975 Protein denotes RPS3
T3494 5997-6007 Gene_expression denotes expressing
T3495 6015-6026 Negative_regulation denotes kinase-dead
T3496 6037-6058 Positive_regulation denotes constitutively-active
T3497 6073-6077 Protein denotes IKKβ
T3498 6105-6109 Positive_regulation denotes SSEE
T3499 6119-6123 Negative_regulation denotes SSAA
T3500 6135-6139 Protein denotes IKKβ
T3501 6140-6147 Positive_regulation denotes induced true
T3502 6140-6147 Positive_regulation denotes induced true
T3503 6154-6163 Regulation denotes dependent
T3504 6164-6174 Protein denotes luciferase
T3505 6218-6222 Protein denotes RPS3
T3506 6223-6231 Localization denotes remained
T3507 6232-6241 Entity denotes cytosolic
T3508 6242-6244 Positive_regulation denotes in
T3509 6245-6249 Protein denotes IKKβ
T3510 6251-6255 Negative_regulation denotes SSAA
T3511 6320-6324 Protein denotes RPS3
T3512 6325-6337 Localization denotes translocated
T3513 6345-6352 Entity denotes nucleus
T3514 6353-6355 Positive_regulation denotes in
T3515 6373-6377 Protein denotes IKKβ
T3516 6379-6383 Positive_regulation denotes SSEE
T3517 6438-6448 Localization denotes detectable
T3518 6449-6456 Entity denotes nuclear
T3519 6457-6461 Protein denotes RPS3
T3520 6462-6471 Positive_regulation denotes increased true
T3521 6462-6471 Positive_regulation denotes increased true
T3522 6482-6486 Protein denotes IKKβ
T3523 6488-6492 Positive_regulation denotes SSEE
T3524 6523-6527 Protein denotes IKKβ
T3525 6529-6533 Negative_regulation denotes SSAA
T3526 6593-6597 Protein denotes IKKβ
T3527 6610-6619 Positive_regulation denotes necessary
T3528 6639-6643 Protein denotes RPS3
T3529 6644-6651 Entity denotes nuclear
T3530 6652-6665 Localization denotes translocation
T3531 6666-6680 Positive_regulation denotes in response to
T5027 6708-6712 Protein denotes IκBα
T5028 6713-6724 Protein_catabolism denotes degradation true
T5029 6729-6733 Protein denotes RPS3
T5030 6734-6741 Entity denotes nuclear
T5031 6742-6755 Localization denotes translocation true
T5032 6767-6776 Regulation denotes regulates
T5033 6781-6788 Entity denotes nuclear
T5034 6789-6795 Localization denotes import
T5035 6805-6808 Protein denotes Rel
T5036 6825-6829 Protein denotes RPS3
T5037 6891-6898 Entity denotes nuclear
T5038 6899-6912 Localization denotes translocation
T5039 6958-6961 Protein denotes p65
T5040 6962-6975 Localization denotes translocation
T5041 6997-7001 Protein denotes RPS3
T5042 7076-7080 Protein denotes RPS3
T5043 7209-7213 Protein denotes RPS3
T5044 7214-7221 Binding denotes binding
T5045 7239-7248 Positive_regulation denotes essential
T5046 7253-7260 Entity denotes nuclear
T5047 7261-7274 Localization denotes translocation
T5048 7306-7310 Protein denotes IκBα
T5049 7311-7322 Protein_catabolism denotes degradation
T5050 7328-7340 Positive_regulation denotes prerequisite
T5051 7344-7350 Regulation denotes unmask
T5052 7355-7358 Entity denotes NLS
T5053 7362-7365 Protein denotes p65
T5054 7376-7380 Protein denotes RPS3
T5055 7385-7389 Protein denotes IκBα
T5056 7390-7394 Binding denotes bind
T5057 7390-7394 Binding denotes bind
T5058 7398-7401 Protein denotes p65
T5059 7459-7463 Protein denotes IκBα
T5060 7464-7475 Protein_catabolism denotes degradation
T5061 7479-7487 Positive_regulation denotes required true
T5062 7496-7506 Localization denotes liberation
T5063 7510-7514 Protein denotes RPS3
T5064 7532-7543 Binding denotes association true
T5065 7547-7551 Protein denotes RPS3
T5066 7607-7611 Protein denotes IκBα
T5067 7618-7622 Protein denotes IκBα
T5068 7631-7635 Negative_regulation denotes SSAA
T5069 7637-7646 Negative_regulation denotes resistant
T5070 7637-7646 Negative_regulation denotes resistant
T5071 7650-7654 Protein denotes IKKβ
T5072 7655-7662 Positive_regulation denotes induced
T5073 7655-7662 Positive_regulation denotes induced
T5074 7663-7678 Phosphorylation denotes phosphorylation
T5075 7683-7694 Protein_catabolism denotes degradation
T5076 7732-7736 Protein denotes IκBα
T5077 7754-7763 Positive_regulation denotes augmented
T5078 7768-7779 Binding denotes interaction
T5079 7783-7787 Protein denotes RPS3
T5080 7886-7890 Protein denotes RPS3
T5081 7902-7913 Binding denotes association
T5082 7918-7927 Negative_regulation denotes abolished
T5083 7951-7961 Protein_catabolism denotes degradable true
T5084 7962-7966 Protein denotes IκBα
T5085 7997-8001 Protein denotes IκBα
T5086 8034-8044 Negative_regulation denotes precluding true
T5087 8045-8049 Protein denotes RPS3
T5088 8050-8057 Entity denotes nuclear
T5089 8058-8071 Localization denotes translocation
T5090 8090-8094 Protein denotes RPS3
T5091 8106-8117 Binding denotes association true
T5092 8130-8134 Protein denotes RPS3
T5093 8141-8149 Negative_regulation denotes reducing
T5094 8150-8154 Protein denotes IκBα
T5095 8155-8165 Gene_expression denotes expression
T5096 8200-8205 Protein denotes siRNA
T5097 8219-8223 Protein denotes IκBα
T5098 8235-8243 Negative_regulation denotes depleted
T5099 8244-8248 Protein denotes IκBα
T5100 8301-8305 Protein denotes RPS3
T5101 8317-8328 Binding denotes association
T5102 8337-8346 Positive_regulation denotes augmented true
T5103 8378-8385 Entity denotes nuclear
T5104 8386-8390 Protein denotes RPS3
T5105 8391-8399 Localization denotes detected true
T5106 8467-8473 Positive_regulation denotes induce
T5107 8474-8478 Protein denotes IκBα
T5108 8479-8490 Protein_catabolism denotes degradation
T5109 8546-8555 Positive_regulation denotes increased true
T5110 8546-8555 Positive_regulation denotes increased true
T5111 8556-8567 Binding denotes association
T5112 8576-8580 Protein denotes RPS3
T5113 8635-8642 Entity denotes nuclear
T5114 8643-8655 Localization denotes accumulation
T5115 8659-8663 Protein denotes RPS3
T5116 8682-8686 Protein denotes IκBα
T5117 8687-8698 Protein_catabolism denotes degradation
T5118 8803-8811 Positive_regulation denotes promotes true
T5119 8803-8811 Positive_regulation denotes promotes true
T5120 8827-8838 Binding denotes association
T5121 8843-8850 Entity denotes nuclear
T5122 8851-8860 Localization denotes transport
T5123 8864-8868 Protein denotes RPS3
T5124 8875-8879 Protein denotes IκBα
T5125 8880-8891 Protein_catabolism denotes degradation
T5126 8950-8958 Positive_regulation denotes required
T5127 8967-8971 Protein denotes RPS3
T5128 8983-8994 Binding denotes association
T5129 9049-9053 Protein denotes IκBα
T5130 9054-9069 Phosphorylation denotes phosphorylation
T5131 9074-9085 Protein_catabolism denotes degradation
T5132 9127-9132 Positive_regulation denotes cause
T5133 9127-9132 Positive_regulation denotes cause
T5134 9133-9137 Protein denotes RPS3
T5135 9138-9149 Binding denotes association
T5136 9166-9174 Positive_regulation denotes followed
T5137 9178-9185 Entity denotes nuclear
T5138 9186-9199 Localization denotes translocation
T5139 9243-9247 Protein denotes IKKβ
T5140 9248-9263 Phosphorylation denotes phosphorylation
T5141 9267-9271 Protein denotes RPS3
T7051 9287-9291 Protein denotes IKKβ
T7052 9292-9306 Phosphorylation denotes phosphorylates
T7053 9307-9311 Protein denotes RPS3
T7054 9315-9325 Entity denotes serine 209
T7055 9395-9399 Protein denotes IKKβ
T7056 9405-9419 Phosphorylation denotes phosphorylates
T7057 9405-9419 Phosphorylation denotes phosphorylates
T7058 9451-9458 Protein denotes 14-3-3β
T7059 9463-9468 Protein denotes Bcl10
T7060 9552-9556 Protein denotes IKKβ
T7061 9572-9585 Phosphorylation denotes phosphorylate true
T7062 9586-9590 Protein denotes RPS3
T7063 9644-9648 Protein denotes RPS3
T7064 9678-9698 Phosphorylation denotes incorporation of 32P
T7065 9678-9698 Phosphorylation denotes incorporation of 32P
T7066 9702-9719 Phosphorylation denotes autophosphorylatd
T7067 9702-9719 Phosphorylation denotes autophosphorylatd
T7068 9720-9724 Protein denotes IKKα
T7069 9729-9733 Protein denotes IKKβ
T7070 9766-9779 Phosphorylation denotes phosporylated true
T7071 9766-9779 Phosphorylation denotes phosporylated true
T7072 9780-9788 Protein denotes GST-IκBα
T7073 9832-9835 Protein denotes GST
T7074 9888-9892 Protein denotes IKKα
T7075 9896-9900 Protein denotes IKKβ
T7076 9930-9938 Protein denotes GST-RPS3
T7077 9948-9962 Phosphorylation denotes phosphorylated true true
T7078 9948-9962 Phosphorylation denotes phosphorylated true
T7079 9966-9970 Protein denotes IKKβ
T7080 9980-9984 Protein denotes IKKα
T7081 10045-10049 Protein denotes RPS3
T7082 10050-10071 Entity denotes amino acid residue(s)
T7083 10072-10086 Phosphorylation denotes phosphorylated
T7084 10090-10094 Protein denotes IKKβ
T7085 10180-10194 Phosphorylation denotes phosphorylated
T7086 10195-10199 Protein denotes RPS3
T7087 10228-10232 Protein denotes IKKβ
T7088 10233-10247 Phosphorylation denotes phosphorylated
T7089 10248-10252 Entity denotes S209
T7090 10269-10273 Protein denotes RPS3
T7091 10296-10300 Protein denotes RPS3
T7092 10599-10603 Protein denotes IKKβ
T7093 10650-10656 Protein denotes kinase
T7094 10694-10699 Entity denotes S209A
T7095 10700-10706 Regulation denotes mutant
T7096 10707-10711 Protein denotes RPS3
T7097 10763-10768 Entity denotes S209A
T7098 10769-10777 Regulation denotes mutation
T7099 10778-10785 Negative_regulation denotes reduced
T7100 10786-10791 Protein denotes IKKβ–
T7101 10791-10799 Positive_regulation denotes mediated
T7102 10800-10804 Protein denotes RPS3
T7103 10805-10820 Phosphorylation denotes phosphorylation
T7104 10928-10942 Phosphorylation denotes phosphorylated
T7105 10943-10947 Protein denotes RPS3
T7106 10959-10963 Protein denotes RPS3
T7107 11052-11066 Entity denotes sequence motif
T7108 11093-11103 Binding denotes recognized
T7109 11140-11144 Protein denotes IKKβ
T7110 11298-11302 Protein denotes RPS3
T7111 11303-11307 Entity denotes S209
T7112 11308-11323 Phosphorylation denotes phosphorylation
T7113 11328-11331 Positive_regulation denotes due true
T7114 11368-11372 Protein denotes IKKβ
T7115 11452-11456 Entity denotes S209
T7116 11464-11472 Positive_regulation denotes critical true
T7117 11487-11491 Protein denotes IKKβ
T7118 11492-11506 Phosphorylation denotes phosphorylates
T7119 11507-11511 Protein denotes RPS3
T7120 11532-11543 Gene_expression denotes transfected
T7121 11532-11543 Gene_expression denotes transfected
T7122 11574-11583 Protein denotes Flag-RPS3
T7123 11608-11612 Protein denotes IKKβ
T7124 11650-11664 Positive_regulation denotes overexpressing
T7125 11665-11669 Protein denotes IKKβ
T7126 11670-11678 Positive_regulation denotes enhanced
T7127 11679-11688 Protein denotes Flag-RPS3
T7128 11689-11704 Phosphorylation denotes phosphorylation
T7129 11742-11752 Negative_regulation denotes eliminated
T7130 11756-11776 Regulation denotes alanine substitution
T7131 11793-11797 Entity denotes S209
T7132 11833-11837 Protein denotes IKKβ
T7133 11838-11853 Phosphorylation denotes phosphorylation
T7134 11885-11911 Protein denotes phospho-S209 RPS3 antibody
T7135 11942-11946 Protein denotes RPS3
T7136 11951-11965 Phosphorylation denotes phosphorylated
T7137 11969-11973 Entity denotes S209
T7138 11984-11993 Regulation denotes dependent
T7139 12001-12005 Positive_regulation denotes upon
T7140 12043-12047 Protein denotes RPS3
T9002 12116-12131 Phosphorylation denotes Phosphorylation
T9003 12135-12139 Protein denotes RPS3
T9004 12188-12192 Entity denotes S209
T9005 12193-12208 Phosphorylation denotes phosphorylation
T9006 12209-12221 Regulation denotes plays a role true
T9007 12229-12236 Entity denotes nuclear
T9008 12237-12250 Localization denotes translocation
T9009 12254-12258 Protein denotes RPS3
T9010 12331-12336 Entity denotes S209A
T9011 12337-12343 Regulation denotes mutant
T9012 12344-12348 Protein denotes RPS3
T9013 12583-12592 Positive_regulation denotes triggered
T9014 12603-12612 Protein denotes Flag-RPS3
T9015 12613-12620 Entity denotes nuclear
T9016 12621-12634 Localization denotes translocation
T9017 12655-12659 Protein denotes RPS3
T9018 12661-12666 Entity denotes S209A
T9019 12668-12675 Entity denotes nuclear
T9020 12676-12689 Localization denotes translocation
T9021 12694-12704 Negative_regulation denotes attenuated
T9022 12735-12741 Regulation denotes impact true
T9023 12765-12779 Positive_regulation denotes overexpressing
T9024 12780-12784 Protein denotes IKKβ
T9025 12788-12792 Protein denotes RPS3
T9026 12793-12800 Entity denotes nuclear
T9027 12801-12814 Localization denotes translocation
T9028 12816-12820 Protein denotes IKKβ
T9029 12864-12874 Protein denotes luciferase
T9030 12915-12922 Positive_regulation denotes induced true
T9031 12927-12934 Entity denotes nuclear
T9032 12935-12948 Localization denotes translocation
T9033 12978-12982 Protein denotes RPS3
T9034 13018-13022 Entity denotes S209
T9035 13023-13038 Phosphorylation denotes phosphorylation
T9036 13042-13050 Positive_regulation denotes critical
T9037 13076-13083 Positive_regulation denotes induced
T9038 13084-13088 Protein denotes RPS3
T9039 13089-13096 Entity denotes nuclear
T9040 13097-13110 Localization denotes translocation
T9041 13135-13139 Entity denotes S209
T9042 13140-13155 Phosphorylation denotes phosphorylation
T9043 13159-13163 Protein denotes RPS3
T9044 13198-13206 Negative_regulation denotes silenced
T9045 13218-13222 Protein denotes RPS3
T9046 13223-13233 Gene_expression denotes expression
T9047 13301-13305 Protein denotes RPS3
T9048 13378-13382 Protein denotes RPS3
T9049 13387-13399 Gene_expression denotes transfection
T9050 13414-13424 Protein denotes RPS3 siRNA
T9051 13434-13441 Negative_regulation denotes reduced
T9052 13453-13457 Protein denotes RPS3
T9053 13502-13508 Regulation denotes affect true
T9054 13520-13530 Gene_expression denotes expression
T9055 13534-13550 Protein denotes Flag-tagged RPS3
T9056 13629-13633 Protein denotes RPS3
T9057 13634-13643 Negative_regulation denotes knockdown
T9058 13644-13651 Negative_regulation denotes reduced
T9059 13656-13663 Positive_regulation denotes induced
T9060 13664-13674 Gene_expression denotes expression
T9061 13687-13693 Positive_regulation denotes driven
T9062 13694-13704 Protein denotes luciferase
T9063 13731-13739 Negative_regulation denotes impaired
T9064 13740-13750 Protein denotes luciferase
T9065 13758-13764 Positive_regulation denotes caused
T9066 13768-13772 Protein denotes RPS3
T9067 13773-13783 Negative_regulation denotes deficiency
T9068 13811-13823 Gene_expression denotes transfecting
T9069 13852-13856 Protein denotes RPS3
T9070 14040-14054 Gene_expression denotes overexpression
T9071 14058-14083 Protein denotes green fluorescent protein
T9072 14085-14088 Protein denotes GFP
T9073 14151-14155 Protein denotes RPS3
T9074 14220-14224 Protein denotes RPS3
T9075 14225-14229 Entity denotes S209
T9076 14230-14245 Phosphorylation denotes phosphorylation
T9077 14377-14381 Entity denotes S209
T9078 14382-14397 Phosphorylation denotes phosphorylation
T9079 14398-14405 Regulation denotes affects true
T9080 14398-14405 Regulation denotes affects true
T9081 14406-14410 Protein denotes RPS3
T9082 14415-14418 Protein denotes p65
T9083 14419-14430 Binding denotes recruitment
T9084 14419-14430 Binding denotes recruitment
T9085 14500-14504 Protein denotes RPS3
T9086 14505-14514 Negative_regulation denotes knockdown
T9087 14528-14538 Positive_regulation denotes stimulated true
T9088 14528-14538 Positive_regulation denotes stimulated true
T9089 14528-14538 Positive_regulation denotes stimulated true
T9090 14528-14538 Positive_regulation denotes stimulated true
T9091 14543-14554 Binding denotes recruitment
T9092 14543-14554 Binding denotes recruitment
T9093 14543-14554 Binding denotes recruitment
T9094 14543-14554 Binding denotes recruitment
T9095 14570-14579 Gene_expression denotes expressed
T9096 14612-14617 Entity denotes S209A
T9097 14618-14622 Protein denotes RPS3
T9098 14630-14638 Entity denotes κB sites
T9099 14646-14652 Protein denotes NFKBIA
T9100 14657-14660 Protein denotes IL8
T9101 14699-14703 Protein denotes RPS3
T9102 14704-14709 Entity denotes S209A
T9103 14717-14723 Regulation denotes impact true
T9104 14727-14730 Protein denotes p65
T9105 14731-14738 Entity denotes nuclear
T9106 14739-14752 Localization denotes translocation
T9107 14771-14781 Negative_regulation denotes attenuated
T9108 14782-14785 Protein denotes p65
T9109 14786-14797 Binding denotes recruitment
T9110 14846-14849 Protein denotes p65
T9111 14850-14860 Localization denotes attraction
T9112 14864-14868 Protein denotes RPS3
T9113 14899-14908 Entity denotes promoters
T9114 14917-14921 Protein denotes CD25
T9115 14926-14935 Positive_regulation denotes increased
T9116 15029-15038 Protein denotes Flag-RPS3
T9117 15042-15045 Protein denotes p65
T9118 15046-15057 Localization denotes recruitment true
T9119 15046-15057 Localization denotes recruitment true
T9120 15061-15065 Protein denotes ACTB
T9121 15066-15074 Entity denotes promoter
T9122 15142-15150 Regulation denotes specific true
T9123 15162-15173 Localization denotes recruitment
T9124 15177-15181 Protein denotes RPS3
T9125 15208-15219 Localization denotes recruitment
T9126 15223-15226 Protein denotes p65
T9127 15234-15243 Entity denotes promoters
T9128 15244-15252 Regulation denotes depended
T9129 15244-15252 Regulation denotes depended
T9130 15256-15260 Entity denotes S209
T9131 15262-15275 Protein denotes Interleukin 8
T9132 15277-15281 Protein denotes IL-8
T9133 15283-15292 Localization denotes secretion
T9134 15293-15300 Positive_regulation denotes induced
T9135 15341-15352 Positive_regulation denotes stimulation
T9136 15366-15375 Negative_regulation denotes decreased
T9137 15396-15403 Negative_regulation denotes reduced
T9138 15404-15408 Protein denotes RPS3
T9139 15409-15412 Protein denotes p65
T9140 15413-15424 Binding denotes recruitment
T9141 15432-15435 Protein denotes IL8
T9142 15436-15444 Entity denotes κB sites
T9143 15464-15469 Entity denotes S209A
T9144 15499-15503 Protein denotes RPS3
T9145 15551-15555 Protein denotes CD25
T9146 15556-15566 Gene_expression denotes expression
T9147 15614-15618 Protein denotes RPS3
T9148 15619-15630 Gene_expression denotes transfected
T9149 15673-15677 Protein denotes RPS3
T9150 15678-15682 Entity denotes S209
T9151 15683-15698 Phosphorylation denotes phosphorylation
T9152 15699-15701 Positive_regulation denotes by
T9153 15702-15706 Protein denotes IKKβ
T9154 15734-15738 Protein denotes RPS3
T11830 15797-15802 Protein denotes NleH1
T11831 15803-15811 Negative_regulation denotes inhibits
T11832 15812-15816 Protein denotes RPS3
T11833 15817-15832 Phosphorylation denotes phosphorylation
T11834 16148-16153 Protein denotes NleH1
T11835 16154-16159 Binding denotes binds
T11836 16167-16177 Negative_regulation denotes attenuates
T11837 16178-16182 Protein denotes RPS3
T11838 16183-16190 Entity denotes nuclear
T11839 16191-16204 Localization denotes translocation
T11840 16221-16225 Protein denotes RPS3
T11841 16285-16290 Protein denotes NleH1
T11842 16307-16317 Negative_regulation denotes inhibiting
T11843 16318-16322 Protein denotes RPS3
T11844 16323-16327 Entity denotes S209
T11845 16328-16343 Phosphorylation denotes phosphorylation
T11846 16371-16381 Positive_regulation denotes increasing
T11847 16393-16401 Protein denotes NleH1-HA
T11848 16418-16422 Protein denotes TNFα
T11849 16501-16506 Protein denotes NleH1
T11850 16507-16514 Negative_regulation denotes reduced
T11851 16507-16514 Negative_regulation denotes reduced
T11852 16520-16523 Protein denotes TNF
T11853 16524-16531 Positive_regulation denotes induced
T11854 16550-16554 Protein denotes RPS3
T11855 16555-16570 Phosphorylation denotes phosphorylation
T11856 16616-16626 Gene_expression denotes Expressing
T11857 16627-16632 Protein denotes NleH1
T11858 16642-16651 Negative_regulation denotes interfere
T11859 16642-16651 Negative_regulation denotes interfere
T11860 16664-16667 Protein denotes TNF
T11861 16680-16690 Positive_regulation denotes activation
T11862 16694-16698 Protein denotes IκBα
T11863 16699-16710 Protein_catabolism denotes degradation
T11864 16732-16736 Negative_regulation denotes lack
T11865 16740-16745 Protein denotes NleH1
T11866 16746-16752 Regulation denotes impact
T11867 16756-16759 Protein denotes p65
T11868 16760-16767 Entity denotes nuclear
T11869 16768-16781 Localization denotes translocation
T11870 16810-16815 Protein denotes NleH1
T11871 16816-16824 Negative_regulation denotes inhibits true
T11872 16825-16829 Protein denotes RPS3
T11873 16830-16845 Phosphorylation denotes phosphorylation
T11874 16913-16920 Negative_regulation denotes lacking
T11875 16928-16933 Protein denotes nleH1
T11876 16935-16941 Protein denotes ΔnleH1
T11877 17003-17008 Protein denotes NleH1
T11878 17031-17036 Protein denotes ΔescN
T11879 17060-17063 Protein denotes TNF
T11880 17095-17103 Positive_regulation denotes increase
T11881 17107-17111 Protein denotes RPS3
T11882 17112-17116 Entity denotes S209
T11883 17117-17132 Phosphorylation denotes phosphorylation
T11884 17180-17184 Protein denotes RPS3
T11885 17185-17189 Entity denotes S209
T11886 17190-17205 Phosphorylation denotes phosphorylation
T11887 17224-17232 Negative_regulation denotes impaired
T11888 17302-17305 Protein denotes TNF
T11889 17306-17313 Positive_regulation denotes induced
T11890 17314-17318 Protein denotes RPS3
T11891 17319-17323 Entity denotes S209
T11892 17324-17339 Phosphorylation denotes phosphorylation
T11893 17344-17354 Negative_regulation denotes unimpaired true
T11894 17344-17354 Negative_regulation denotes unimpaired true
T11895 17385-17391 Protein denotes ΔnleH1
T11896 17395-17400 Protein denotes ΔescN
T11897 17457-17463 Protein denotes ΔnleH1
T11898 17467-17472 Protein denotes ΔescN
T11899 17503-17513 Negative_regulation denotes attenuated
T11900 17503-17513 Negative_regulation denotes attenuated
T11901 17514-17517 Protein denotes TNF
T11902 17518-17525 Positive_regulation denotes induced
T11903 17526-17530 Protein denotes RPS3
T11904 17531-17538 Entity denotes nuclear
T11905 17539-17552 Localization denotes translocation
T11906 17576-17580 Protein denotes RPS3
T11907 17581-17596 Phosphorylation denotes phosphorylation
T11908 17605-17612 Entity denotes nuclear
T11909 17613-17626 Localization denotes translocation
T11910 17728-17732 Protein denotes RPS3
T11911 17733-17737 Entity denotes S209
T11912 17738-17753 Phosphorylation denotes phosphorylation
T11913 17757-17766 Regulation denotes important
T11914 17771-17778 Entity denotes nuclear
T11915 17779-17792 Localization denotes translocation
T11916 17813-17818 Protein denotes NleH1
T11917 17819-17827 Negative_regulation denotes inhibits
T11918 17828-17832 Protein denotes RPS3
T11919 17833-17837 Entity denotes S209
T11920 17838-17853 Phosphorylation denotes phosphorylation
T11921 17891-17895 Protein denotes RPS3
T11922 17944-17947 Protein denotes IL8
T11923 17949-17955 Protein denotes NFKBIA
T11924 17961-17968 Protein denotes TNFAIP3
T11925 18128-18134 Protein denotes ΔnleH1
T11926 18138-18143 Protein denotes ΔescN
T11927 18176-18184 Negative_regulation denotes deleting
T11928 18185-18190 Protein denotes nleH1
T11929 18260-18264 Protein denotes CD25
T11930 18269-18277 Protein denotes TNFSF13B
T11931 18343-18348 Protein denotes NleH1
T11932 18414-18422 Negative_regulation denotes blocking
T11933 18423-18427 Protein denotes RPS3
T11934 18428-18432 Entity denotes S209
T11935 18433-18448 Phosphorylation denotes phosphorylation
T11936 18480-18484 Protein denotes RPS3
T14712 19705-19723 Phosphorylation denotes autophosphorylated
T14713 19755-19762 Regulation denotes depends
T14714 19770-19780 Entity denotes lysine 159
T14715 19824-19829 Protein denotes NleH1
T14716 19830-19838 Negative_regulation denotes inhibits
T14717 19839-19843 Protein denotes RPS3
T14718 19844-19848 Entity denotes S209
T14719 19849-19864 Phosphorylation denotes phosphorylation
T14720 19934-19943 Protein denotes His-NleH1
T14721 19965-19974 Protein denotes His-NleH1
T14722 20008-20013 Protein denotes NleH1
T14723 20017-20035 Phosphorylation denotes autophosphorylated
T14724 20044-20049 Entity denotes K159A
T14725 20056-20061 Protein denotes NleH1
T14726 20062-20073 Negative_regulation denotes kinase-dead
T14727 20134-20142 Regulation denotes required true
T14728 20147-20152 Protein denotes NleH1
T14729 20156-20163 Negative_regulation denotes inhibit
T14730 20164-20168 Protein denotes IKKβ
T14731 20169-20184 Phosphorylation denotes phosphorlyation
T14732 20188-20192 Protein denotes RPS3
T14733 20196-20200 Entity denotes S209
T14734 20254-20259 Protein denotes NleH1
T14735 20285-20290 Protein denotes NleH1
T14736 20291-20301 Gene_expression denotes expression
T14737 20316-20323 Negative_regulation denotes reduced
T14738 20328-20335 Positive_regulation denotes induced
T14739 20336-20340 Protein denotes RPS3
T14740 20341-20345 Entity denotes S209
T14741 20346-20361 Phosphorylation denotes phosphorylation
T14742 20388-20394 Negative_regulation denotes failed
T14743 20420-20425 Protein denotes NleH1
T14744 20445-20453 Positive_regulation denotes required
T14745 20457-20464 Negative_regulation denotes protect
T14746 20465-20469 Protein denotes RPS3
T14747 20475-20479 Protein denotes IKKβ
T14748 20480-20488 Positive_regulation denotes mediated
T14749 20489-20504 Phosphorylation denotes phosphorylation
T14750 20648-20652 Protein denotes NleH
T14751 20653-20662 Negative_regulation denotes inhibited
T14752 20653-20662 Negative_regulation denotes inhibited
T14753 20663-20667 Protein denotes RPS3
T14754 20668-20675 Entity denotes nuclear
T14755 20676-20689 Localization denotes translocation
T14756 20694-20698 Protein denotes RPS3
T14757 20699-20708 Regulation denotes dependent
T14758 20715-20725 Protein denotes luciferase
T14759 20726-20734 Positive_regulation denotes activity
T14760 20770-20775 Protein denotes NleH1
T14761 20797-20801 Protein denotes RPS3
T14762 20802-20806 Entity denotes S209
T14763 20807-20822 Phosphorylation denotes phosphorylation
T14764 20941-20949 Positive_regulation denotes increase
T14765 20953-20957 Protein denotes RPS3
T14766 20958-20962 Entity denotes S209
T14767 20963-20978 Phosphorylation denotes phosphorylation
T14768 20995-21007 Positive_regulation denotes augmentation
T14769 21011-21015 Protein denotes RPS3
T14770 21016-21031 Phosphorylation denotes phosphorylation
T14771 21036-21043 Negative_regulation denotes reduced
T14772 21113-21117 Protein denotes RPS3
T14773 21118-21133 Phosphorylation denotes phosphorylation
T14774 21138-21146 Positive_regulation denotes enhanced
T14775 21199-21206 Negative_regulation denotes lacking
T14776 21207-21211 Protein denotes NleH
T14777 21222-21227 Protein denotes ΔnleH
T14778 21262-21267 Protein denotes NleH1
T14779 21307-21312 Protein denotes ΔnleH
T14780 21348-21355 Gene_expression denotes express
T14781 21390-21395 Protein denotes NleH1
T14782 21411-21416 Protein denotes ΔnleH
T14783 21439-21444 Protein denotes NleH1
T14784 21452-21461 Negative_regulation denotes abolished
T14785 21462-21465 Protein denotes TNF
T14786 21466-21473 Positive_regulation denotes induced
T14787 21474-21478 Protein denotes RPS3
T14788 21479-21483 Entity denotes S209
T14789 21484-21499 Phosphorylation denotes phosphorylation
T14790 21543-21550 Negative_regulation denotes inhibit true
T14791 21551-21555 Protein denotes RPS3
T14792 21556-21571 Phosphorylation denotes phosphorylation
T14793 21628-21633 Protein denotes NleH1
T14794 21653-21661 Positive_regulation denotes required
T14795 21665-21670 Negative_regulation denotes block
T14796 21671-21675 Protein denotes RPS3
T14797 21676-21680 Entity denotes S209
T14798 21681-21696 Phosphorylation denotes phosphorylation
T14799 21750-21755 Protein denotes NleH1
T14800 21782-21788 Negative_regulation denotes impair true
T14801 21800-21807 Entity denotes nuclear
T14802 21808-21821 Localization denotes translocation
T14803 21825-21829 Protein denotes RPS3
T14804 21830-21837 Positive_regulation denotes trigged
T14805 21845-21866 Positive_regulation denotes constitutively-active
T14806 21867-21871 Protein denotes IKKβ
T14807 21873-21877 Protein denotes IKKβ
T14808 21879-21883 Positive_regulation denotes SSEE
T14809 21954-21963 Protein denotes SSEE IKKβ
T14810 21974-21983 Positive_regulation denotes triggered
T14811 21989-21993 Protein denotes RPS3
T14812 21994-22001 Entity denotes nuclear
T14813 22002-22015 Localization denotes translocation
T14814 22025-22036 Negative_regulation denotes kinase-dead
T14815 22037-22041 Protein denotes IKKβ
T14816 22043-22047 Negative_regulation denotes SSAA
T14817 22068-22072 Protein denotes RPS3
T14818 22073-22080 Entity denotes nuclear
T14819 22081-22093 Localization denotes accumulation
T14820 22112-22120 Negative_regulation denotes retarded
T14821 22217-22223 Protein denotes ΔnleH1
T14822 22227-22232 Protein denotes ΔescN
T14823 22264-22268 Protein denotes RPS3
T14824 22269-22276 Entity denotes nuclear
T14825 22277-22290 Localization denotes translocation
T14826 22301-22305 Protein denotes IKKβ
T14827 22310-22314 Protein denotes IKKβ
T14828 22316-22320 Positive_regulation denotes SSEE
T14829 22322-22332 Gene_expression denotes expressing
T14830 22322-22332 Gene_expression denotes expressing
T14831 22390-22396 Regulation denotes affect true
T14832 22401-22405 Protein denotes RPS3
T14833 22406-22413 Entity denotes nuclear
T14834 22414-22427 Localization denotes translocation
T14835 22431-22435 Protein denotes IKKβ
T14836 22437-22441 Negative_regulation denotes SSAA
T14837 22443-22453 Gene_expression denotes expressing
T14838 22525-22530 Protein denotes NleH1
T14839 22557-22564 Negative_regulation denotes inhibit
T14840 22565-22569 Protein denotes RPS3
T14841 22570-22577 Entity denotes nuclear
T14842 22578-22591 Localization denotes translocation
T14843 22606-22616 Gene_expression denotes expressing
T14844 22632-22641 Positive_regulation denotes activated
T14845 22642-22646 Protein denotes IKKβ
T14846 22668-22673 Protein denotes NleH1
T14847 22689-22702 Phosphorylation denotes phosphorylate
T14848 22703-22707 Protein denotes IKKβ
T14849 22708-22712 Positive_regulation denotes thus true
T14850 22713-22723 Negative_regulation denotes inhibiting
T14851 22724-22728 Protein denotes IKKβ
T14852 22729-22737 Positive_regulation denotes mediated
T14853 22738-22742 Protein denotes RPS3
T14854 22743-22747 Entity denotes S209
T14855 22748-22763 Phosphorylation denotes phosphorylation
T14856 22826-22842 Protein denotes Flag-IKKβ (K44A)
T14857 22872-22881 Protein denotes His-NleH1
T14858 22901-22905 Protein denotes IKKβ
T14859 22906-22925 Phosphorylation denotes autophosphorylation
T14860 22944-22949 Protein denotes NleH1
T14861 22958-22973 Phosphorylation denotes phosphorylation
T14862 23018-23035 Phosphorylation denotes 32P incorporation true
T14863 23039-23043 Protein denotes IKKβ
T14864 23138-23143 Protein denotes NleH1
T14865 23160-23164 Protein denotes IKKβ
T14866 23277-23281 Protein denotes IKKβ
T14867 23296-23300 Protein denotes IKKβ
T14868 23301-23315 Phosphorylation denotes phosphorylated
T14869 23301-23315 Phosphorylation denotes phosphorylated
T14870 23316-23320 Protein denotes RPS3
T14871 23343-23351 Protein denotes GST-IκBα
T14872 23429-23450 Regulation denotes substrate specificity
T14873 23469-23473 Protein denotes IKKβ
T14874 23479-23484 Protein denotes NleH1
T14875 23485-23492 Negative_regulation denotes reduced true
T14876 23485-23492 Negative_regulation denotes reduced true
T14877 23493-23497 Protein denotes IKKβ
T14878 23498-23506 Positive_regulation denotes mediated
T14879 23507-23511 Protein denotes RPS3
T14880 23512-23527 Phosphorylation denotes phosphorylation
T14881 23570-23574 Protein denotes IKKβ
T14882 23575-23583 Positive_regulation denotes mediated
T14883 23584-23592 Protein denotes GST-IκBα
T14884 23593-23608 Phosphorylation denotes phosphorylation
T14885 23685-23690 Protein denotes NleH1
T14886 23691-23699 Positive_regulation denotes mediated true
T14887 23691-23699 Positive_regulation denotes mediated true
T14888 23691-23699 Positive_regulation denotes mediated true
T14889 23691-23699 Positive_regulation denotes mediated true
T14890 23700-23715 Phosphorylation denotes phosphorylation
T14891 23700-23715 Phosphorylation denotes phosphorylation
T14892 23719-23738 Phosphorylation denotes autophosphorylation
T14893 23719-23738 Phosphorylation denotes autophosphorylation
T14894 23742-23746 Protein denotes RPS3
T14895 23750-23758 Protein denotes GST-IκBα
T14896 23786-23791 Protein denotes NleH1
T14897 23832-23836 Protein denotes IKKβ
T14898 23842-23852 Negative_regulation denotes inhibiting
T14899 23857-23861 Protein denotes IKKβ
T14900 23862-23870 Positive_regulation denotes mediated
T14901 23871-23875 Protein denotes RPS3
T14902 23876-23880 Entity denotes S209
T14903 23881-23896 Phosphorylation denotes phosphorylation
T18033 24005-24009 Protein denotes RPS3
T18034 24174-24182 Positive_regulation denotes triggers true
T18035 24183-24187 Protein denotes RPS3
T18036 24191-24202 Localization denotes translocate
T18037 24244-24251 Entity denotes nucleus
T18038 24273-24277 Protein denotes IKKβ
T18039 24278-24286 Positive_regulation denotes mediated
T18040 24287-24291 Protein denotes RPS3
T18041 24292-24296 Entity denotes S209
T18042 24297-24312 Phosphorylation denotes phosphorylation
T18043 24326-24334 Regulation denotes critical
T18044 24364-24371 Entity denotes nuclear
T18045 24372-24378 Localization denotes import
T18046 24449-24453 Protein denotes IKKβ
T18047 24586-24590 Protein denotes RPS3
T18048 24716-24720 Protein denotes IKKβ
T18049 24815-24819 Protein denotes IKKβ
T18050 24829-24833 Protein denotes IKKα
T18051 24835-24849 Phosphorylation denotes phosphorylated
T18052 24835-24849 Phosphorylation denotes phosphorylated true
T18053 24850-24854 Protein denotes RPS3
T18054 24900-24910 Regulation denotes modulation
T18055 24900-24910 Regulation denotes modulation
T18056 24915-24919 Protein denotes RPS3
T18057 24920-24927 Entity denotes nuclear
T18058 24928-24941 Localization denotes translocation
T18059 24943-24946 Positive_regulation denotes via
T18060 25035-25048 Phosphorylation denotes phosphorylate
T18061 25049-25052 Protein denotes p65
T18062 25060-25064 Binding denotes bind
T18063 25072-25085 Phosphorylation denotes phosphorylate
T18064 25086-25090 Protein denotes IKKβ
T18065 25144-25148 Protein denotes IKKβ
T18066 25149-25154 Binding denotes bound
T18067 25165-25176 Positive_regulation denotes account for true
T18068 25190-25194 Protein denotes RPS3
T18069 25195-25210 Phosphorylation denotes phosphorylation
T18070 25246-25250 Protein denotes IKKβ
T18071 25308-25312 Protein denotes RPS3
T18072 25534-25538 Protein denotes RPS3
T18073 25687-25691 Protein denotes IKKβ
T18074 25692-25700 Positive_regulation denotes mediated
T18075 25701-25705 Protein denotes RPS3
T18076 25706-25710 Entity denotes S209
T18077 25711-25726 Phosphorylation denotes phosphorylation
T18078 25748-25757 Regulation denotes modulated
T18079 25831-25836 Protein denotes NleH1
T18080 25850-25855 Binding denotes binds
T18081 25859-25863 Protein denotes RPS3
T18082 25997-26002 Protein denotes NleH1
T18083 26015-26023 Negative_regulation denotes inhibits
T18084 26024-26028 Protein denotes RPS3
T18085 26029-26044 Phosphorylation denotes phosphorylation
T18086 26051-26060 Negative_regulation denotes retarding
T18087 26065-26072 Entity denotes nuclear
T18088 26073-26086 Localization denotes translocation
T18089 26167-26172 Protein denotes NleH1
T18090 26190-26203 Phosphorylation denotes phosphorylate true
T18091 26204-26208 Protein denotes IKKβ
T18092 26246-26253 Negative_regulation denotes inhibit
T18093 26254-26258 Protein denotes IKKβ
T18094 26259-26267 Positive_regulation denotes mediated
T18095 26268-26272 Protein denotes RPS3
T18096 26273-26277 Entity denotes S209
T18097 26278-26293 Phosphorylation denotes phosphorylation
T18098 26424-26429 Protein denotes NleH1
T18099 26433-26438 Regulation denotes steer
T18100 26468-26472 Protein denotes IKKβ
T18101 26739-26744 Protein denotes NleH1
T18102 26777-26781 Protein denotes RPS3
T18103 26911-26914 Protein denotes IL8
T18104 26937-26942 Protein denotes NleH1
T18105 26952-26957 Negative_regulation denotes block true
T18106 26964-26967 Protein denotes p65
T18107 26968-26975 Entity denotes nuclear
T18108 26976-26989 Localization denotes translocation
T18109 27019-27022 Protein denotes p65
T18110 27037-27041 Protein denotes RPS3
T18111 27175-27185 Negative_regulation denotes inhibiting
T18112 27186-27190 Protein denotes RPS3
T18113 27229-27234 Protein denotes NleH1
T18114 27821-27829 Negative_regulation denotes impeding
T18115 27830-27834 Protein denotes RPS3
T18116 27844-27852 Regulation denotes altering
T18117 27853-27856 Protein denotes p65
T18118 27857-27864 Entity denotes nuclear
T18119 27865-27878 Localization denotes translocation
T18120 28108-28115 Regulation denotes effects
T18121 28136-28140 Protein denotes RPS3
T20504 29321-29337 Protein denotes Flag-IKKβ (SSEE)
T20505 29339-29355 Protein denotes Flag-IKKβ (SSAA)
T20506 29361-29375 Protein denotes HA-IκBα (SSAA)
T20507 29481-29488 Protein denotes HA-IκBα
T20508 29493-29509 Protein denotes IKKβ (K44A)-Flag
T20509 29558-29567 Protein denotes Flag-RPS3
T20510 29569-29577 Protein denotes GST-RPS3
T20511 29579-29586 Protein denotes HA-RPS3
T20512 29588-29593 Protein denotes VN-HA
T20513 29595-29603 Protein denotes NleH1-HA
T20514 29665-29669 Protein denotes RPS3
T20986 30305-30309 Protein denotes IKKα
T20987 30470-30478 Protein denotes GST-RPS3
T20988 30483-30487 Protein denotes RPS3
T21544 31486-31490 Protein denotes IKKα
T21545 31526-31530 Protein denotes IKKβ
T21546 31566-31570 Protein denotes IκBα
T21547 31606-31610 Protein denotes RPS3
T22035 32742-32752 Protein denotes luciferase
T22211 33114-33117 Protein denotes IL8
T22212 33122-33128 Protein denotes NFKBIA
T22213 33141-33145 Protein denotes ACTB
T22541 34908-34915 Protein denotes albumin
T23100 35151-35155 Protein denotes IL-8
T23101 35242-35255 Protein denotes Interleukin-8
T23102 35275-35278 Protein denotes kit
T20985 30296-30300 Protein denotes IKKβ
T22034 32705-32715 Protein denotes luciferase
T21361 31009-31017 Protein denotes GST-RPS3
T21362 31049-31053 Protein denotes IKKβ
T14709 19647-19652 Protein denotes NleH1
T14710 19664-19668 Protein denotes IKKβ
T14711 19693-19698 Protein denotes NleH1
T13727 18516-18521 Protein denotes NleH1
T13728 18522-18530 Negative_regulation denotes inhibits
T13729 18531-18535 Protein denotes RPS3
T13730 18536-18540 Entity denotes S209
T13731 18541-18556 Phosphorylation denotes phosphorylation
T13732 18665-18671 Protein denotes ΔnleH1
T13733 18771-18777 Protein denotes ΔnleH1
T13734 19007-19012 Protein denotes NleH1
T13735 19013-19020 Negative_regulation denotes blocked
T13736 19021-19025 Protein denotes RPS3
T13737 19026-19030 Entity denotes S209
T13738 19031-19046 Phosphorylation denotes phosphorylation
T13739 19064-19074 Negative_regulation denotes preventing true
T13740 19075-19079 Protein denotes RPS3
T13741 19080-19087 Entity denotes nuclear
T13742 19088-19101 Localization denotes translocation
T13743 19339-19342 Negative_regulation denotes low
T13744 19353-19360 Phosphorylation denotes phospho
T13745 19361-19365 Protein denotes RPS3
T13746 19409-19415 Protein denotes ΔnleH1
T13747 19424-19431 Phosphorylation denotes phospho
T13748 19432-19436 Protein denotes RPS3
T13749 19463-19470 Positive_regulation denotes intense
T13750 19510-19515 Protein denotes NleH1
T13751 19516-19524 Negative_regulation denotes inhibits
T13752 19525-19529 Protein denotes RPS3
T13753 19530-19534 Entity denotes S209
T13754 19535-19550 Phosphorylation denotes phosphorylation
R51 T62 T63 themeOf IKKβ,phosphorylation
R52 T63 T64 causeOf phosphorylation,regulates
R53 T65 T67 themeOf RPS3,translocation
R54 T66 T67 locationOf nuclear,translocation
R55 T67 T64 themeOf translocation,regulates
R56 T69 T68 equivalentTo RPS3,ribosomal protein S3
R57 T70 T72 themeOf RPS3,translocation
R58 T71 T72 locationOf nuclear,translocation
R59 T72 T73 themeOf translocation,regulated
R60 T75 T77 causeOf phosphorylation,crucial
R61 T76 T75 themeOf serine 209,phosphorylation
R62 T76 T74 partOf serine 209,IKKβ
R63 T78 T80 themeOf RPS3,localization
R64 T78 T82 themeOf RPS3,activating
R65 T79 T80 locationOf nuclear,localization
R66 T80 T81 themeOf localization,in response to
R67 T81 T77 themeOf in response to,crucial
R68 T82 T81 causeOf activating,in response to
R69 T83 T84 causeOf NleH1,inhibited
R70 T84 T88 causeOf inhibited,blocked
R71 T86 T87 themeOf S209,phosphorylation
R72 T86 T85 partOf S209,RPS3
R73 T87 T84 themeOf phosphorylation,inhibited
R74 T89 T88 themeOf RPS3,blocked
R75 T90 T91 causeOf IKKβ,dependent
R76 T92 T91 themeOf modification,dependent
R77 T93 T92 themeOf RPS3,modification
R594 T730 T729 equivalentTo p65,RelA
R595 T736 T735 equivalentTo RPS3,ribosomal protein S3
R596 T740 T741 themeOf immunoglobulin κ light chain,expression
R597 T742 T747 causeOf NleH1,affecting
R598 T742 T743 causeOf NleH1,attenuating
R599 T744 T746 themeOf RPS3,translocation
R600 T745 T746 locationOf nuclear,translocation
R601 T746 T743 themeOf translocation,attenuating
R602 T748 T749 themeOf p65,localization
R603 T749 T747 themeOf localization,affecting
R604 T751 T753 themeOf RPS3,translocation
R605 T752 T753 locationOf nuclear,translocation
R606 T753 T750 themeOf translocation,induce
R607 T755 T754 themeOf RPS3,binding
R608 T756 T757 themeOf RPS3,phosphorylated
R609 T758 T759 themeOf RPS3,phosphorylated
R610 T761 T763 causeOf Inhibitor of κB (IκB) kinase beta,phosphorylated
R611 T762 T761 equivalentTo IKKβ,Inhibitor of κB (IκB) kinase beta
R612 T765 T763 themeOf serine 209,phosphorylated
R613 T765 T764 partOf serine 209,RPS3
R614 T766 T770 themeOf RPS3,association
R615 T767 T768 themeOf S209,phosphorylation
R616 T767 T766 partOf S209,RPS3
R617 T768 T769 causeOf phosphorylation,enhanced
R618 T769 T771 causeOf enhanced,mediating
R619 T770 T769 themeOf association,enhanced
R620 T772 T774 themeOf RPS3,translocation
R621 T773 T774 locationOf nuclear,translocation
R622 T774 T771 themeOf translocation,mediating
R623 T775 T776 causeOf NleH1,inhibited
R624 T778 T776 themeOf S209,inhibited
R625 T778 T777 partOf S209,RPS3
R1571 T1988 T1989 themeOf RPS3,phosphorylated
R1572 T1991 T1990 themeOf 32P-incorporation,increase
R1573 T1993 T1991 themeOf RPS3,32P-incorporation
R1574 T1993 T1992 themeOf RPS3,increase
R1575 T1995 T1996 themeOf residues,phosphorylated
R1576 T1995 T1994 partOf residues,RPS3
R1577 T2000 T1999 themeOf phosphorylation,stimulated
R1578 T2001 T1998 themeOf degradaion,stimulated
R1579 T2002 T2000 themeOf IκBα,phosphorylation
R1580 T2002 T2001 themeOf IκBα,degradaion
R1581 T2005 T2004 themeOf serine residues,phosphorylation
R1582 T2005 T2003 partOf serine residues,RPS3
R1583 T2006 T2009 themeOf tyrosine,phosphorylation
R1584 T2006 T2010 partOf tyrosine,RPS3
R1585 T2007 T2008 themeOf threonine,phosphorylation
R1586 T2007 T2010 partOf threonine,RPS3
R2042 T2601 T2603 themeOf RPS3,interaction
R2043 T2602 T2603 themeOf IKKβ,interaction
R2044 T2612 T2611 themeOf IKKβ,activated
R2045 T2612 T2613 themeOf IKKβ,bind
R2046 T2615 T2613 themeOf RPS3,bind
R2047 T2615 T2614 themeOf RPS3,phosphorylate
R2048 T2617 T2616 themeOf IKKβ,expressed
R2049 T2617 T2619 themeOf IKKβ,interacted
R2050 T2618 T2619 themeOf RPS3,interacted
R2051 T2620 T2622 themeOf IKKβ,interaction
R2052 T2621 T2622 themeOf RPS3,interaction
R2053 T2623 T2625 themeOf RPS3,association
R2054 T2624 T2625 themeOf IKKβ,association
R2055 T2625 T2626 themeOf association,augmented
R2056 T2626 T2627 causeOf augmented,following
R2057 T2629 T2630 themeOf serine,phosphorylation
R2058 T2629 T2628 partOf serine,RPS3
R2059 T2630 T2627 themeOf phosphorylation,following
R2060 T2632 T2631 themeOf RPS3,interaction
R2061 T2633 T2631 themeOf IKKα,interaction
R2688 T3438 T3439 causeOf IKKβ,required
R2689 T3440 T3442 themeOf RPS3,translocation
R2690 T3441 T3442 locationOf nuclear,translocation
R2691 T3442 T3439 themeOf translocation,required
R2692 T3443 T3445 themeOf RPS3,interaction
R2693 T3444 T3445 themeOf IKKβ,interaction
R2694 T3445 T3446 causeOf interaction,required
R2695 T3447 T3449 themeOf RPS3,translocation
R2696 T3448 T3449 locationOf nuclear,translocation
R2697 T3449 T3446 themeOf translocation,required
R2698 T3452 T3454 themeOf IKKα,expression
R2699 T3453 T3455 themeOf IKKβ,expression
R2700 T3454 T3450 themeOf expression,knocked down
R2701 T3455 T3451 themeOf expression,knocked down
R2702 T3457 T3459 themeOf RPS3,migration
R2703 T3458 T3459 locationOf nuclear,migration
R2704 T3459 T3456 themeOf migration,induced
R2705 T3461 T3463 themeOf RPS3,translocation
R2706 T3462 T3463 locationOf nuclear,translocation
R2707 T3463 T3460 themeOf translocation,triggered
R2708 T3464 T3466 themeOf RPS3,translocation
R2709 T3465 T3466 locationOf nuclear,translocation
R2710 T3466 T3467 themeOf translocation,impaired
R2711 T3468 T3469 themeOf IKKα,silencing
R2712 T3469 T3467 causeOf silencing,impaired
R2713 T3470 T3472 causeOf knockdown,attenuated
R2714 T3471 T3470 themeOf IKKβ,knockdown
R2715 T3473 T3475 themeOf RPS3,accumulation
R2716 T3474 T3475 locationOf nuclear,accumulation
R2717 T3475 T3476 themeOf accumulation,following
R2718 T3476 T3472 themeOf following,attenuated
R2719 T3477 T3482 causeOf expression,necessary
R2720 T3478 T3481 causeOf expression,necessary
R2721 T3479 T3477 themeOf IKKβ,expression
R2722 T3480 T3478 themeOf IKKα,expression
R2723 T3483 T3482 themeOf induced,necessary
R2724 T3483 T3481 themeOf induced,necessary
R2725 T3484 T3486 themeOf RPS3,translocation
R2726 T3485 T3486 locationOf nuclear,translocation
R2727 T3486 T3483 themeOf translocation,induced
R2728 T3487 T3489 themeOf p65,translocation
R2729 T3488 T3489 locationOf nuclear,translocation
R2730 T3489 T3490 themeOf translocation,blocked
R2731 T3491 T3492 locationOf nuclear,translocation
R2732 T3493 T3492 themeOf RPS3,translocation
R2733 T3497 T3494 themeOf IKKβ,expressing
R2734 T3497 T3495 themeOf IKKβ,kinase-dead
R2735 T3497 T3496 themeOf IKKβ,constitutively-active
R2736 T3498 T3502 causeOf SSEE,induced
R2737 T3499 T3501 causeOf SSAA,induced
R2738 T3500 T3498 themeOf IKKβ,SSEE
R2739 T3500 T3499 themeOf IKKβ,SSAA
R2740 T3503 T3502 themeOf dependent,induced
R2741 T3503 T3501 themeOf dependent,induced
R2742 T3504 T3503 themeOf luciferase,dependent
R2743 T3505 T3506 themeOf RPS3,remained
R2744 T3506 T3508 themeOf remained,in
R2745 T3507 T3506 locationOf cytosolic,remained
R2746 T3509 T3510 themeOf IKKβ,SSAA
R2747 T3510 T3508 causeOf SSAA,in
R2748 T3511 T3512 themeOf RPS3,translocated
R2749 T3512 T3514 themeOf translocated,in
R2750 T3513 T3512 locationOf nucleus,translocated
R2751 T3515 T3516 themeOf IKKβ,SSEE
R2752 T3516 T3514 causeOf SSEE,in
R2753 T3517 T3521 themeOf detectable,increased
R2754 T3517 T3520 themeOf detectable,increased
R2755 T3518 T3517 locationOf nuclear,detectable
R2756 T3519 T3517 themeOf RPS3,detectable
R2757 T3522 T3523 themeOf IKKβ,SSEE
R2758 T3523 T3521 causeOf SSEE,increased
R2759 T3524 T3525 themeOf IKKβ,SSAA
R2760 T3525 T3520 causeOf SSAA,increased
R2761 T3526 T3527 causeOf IKKβ,necessary
R2762 T3528 T3530 themeOf RPS3,translocation
R2763 T3529 T3530 locationOf nuclear,translocation
R2764 T3530 T3531 themeOf translocation,in response to
R2765 T3531 T3527 themeOf in response to,necessary
R4003 T5027 T5028 themeOf IκBα,degradation
R4004 T5029 T5031 themeOf RPS3,translocation
R4005 T5030 T5031 locationOf nuclear,translocation
R4006 T5033 T5034 locationOf nuclear,import
R4007 T5034 T5032 themeOf import,regulates
R4008 T5035 T5034 themeOf Rel,import
R4009 T5036 T5038 themeOf RPS3,translocation
R4010 T5037 T5038 locationOf nuclear,translocation
R4011 T5039 T5040 themeOf p65,translocation
R4012 T5043 T5044 themeOf RPS3,binding
R4013 T5043 T5047 themeOf RPS3,translocation
R4014 T5044 T5045 causeOf binding,essential
R4015 T5046 T5047 locationOf nuclear,translocation
R4016 T5047 T5045 themeOf translocation,essential
R4017 T5048 T5049 themeOf IκBα,degradation
R4018 T5049 T5050 causeOf degradation,prerequisite
R4019 T5051 T5050 themeOf unmask,prerequisite
R4020 T5052 T5051 themeOf NLS,unmask
R4021 T5052 T5053 partOf NLS,p65
R4022 T5054 T5056 themeOf RPS3,bind
R4023 T5055 T5057 themeOf IκBα,bind
R4024 T5058 T5056 themeOf p65,bind
R4025 T5058 T5057 themeOf p65,bind
R4026 T5059 T5060 themeOf IκBα,degradation
R4027 T5060 T5061 causeOf degradation,required
R4028 T5062 T5061 themeOf liberation,required
R4029 T5063 T5062 themeOf RPS3,liberation
R4030 T5065 T5064 themeOf RPS3,association
R4031 T5067 T5068 themeOf IκBα,SSAA
R4032 T5067 T5074 themeOf IκBα,phosphorylation
R4033 T5067 T5075 themeOf IκBα,degradation
R4034 T5068 T5070 causeOf SSAA,resistant
R4035 T5068 T5069 causeOf SSAA,resistant
R4036 T5071 T5073 causeOf IKKβ,induced
R4037 T5071 T5072 causeOf IKKβ,induced
R4038 T5072 T5069 themeOf induced,resistant
R4039 T5073 T5070 themeOf induced,resistant
R4040 T5074 T5073 themeOf phosphorylation,induced
R4041 T5075 T5072 themeOf degradation,induced
R4042 T5078 T5077 themeOf interaction,augmented
R4043 T5079 T5078 themeOf RPS3,interaction
R4044 T5080 T5081 themeOf RPS3,association
R4045 T5081 T5082 themeOf association,abolished
R4046 T5083 T5082 causeOf degradable,abolished
R4047 T5084 T5083 themeOf IκBα,degradable
R4048 T5085 T5086 causeOf IκBα,precluding
R4049 T5087 T5089 themeOf RPS3,translocation
R4050 T5088 T5089 locationOf nuclear,translocation
R4051 T5089 T5086 themeOf translocation,precluding
R4052 T5090 T5091 themeOf RPS3,association
R4053 T5094 T5095 themeOf IκBα,expression
R4054 T5095 T5093 themeOf expression,reducing
R4055 T5096 T5098 causeOf siRNA,depleted
R4056 T5098 T5102 causeOf depleted,augmented
R4057 T5099 T5098 themeOf IκBα,depleted
R4058 T5100 T5101 themeOf RPS3,association
R4059 T5101 T5102 themeOf association,augmented
R4060 T5103 T5105 locationOf nuclear,detected
R4061 T5104 T5105 themeOf RPS3,detected
R4062 T5106 T5109 causeOf induce,increased
R4063 T5106 T5110 causeOf induce,increased
R4064 T5107 T5108 themeOf IκBα,degradation
R4065 T5108 T5106 themeOf degradation,induce
R4066 T5111 T5109 themeOf association,increased
R4067 T5112 T5111 themeOf RPS3,association
R4068 T5113 T5114 locationOf nuclear,accumulation
R4069 T5114 T5110 themeOf accumulation,increased
R4070 T5115 T5114 themeOf RPS3,accumulation
R4071 T5116 T5117 themeOf IκBα,degradation
R4072 T5120 T5119 themeOf association,promotes
R4073 T5121 T5122 locationOf nuclear,transport
R4074 T5122 T5118 themeOf transport,promotes
R4075 T5123 T5120 themeOf RPS3,association
R4076 T5123 T5122 themeOf RPS3,transport
R4077 T5124 T5125 themeOf IκBα,degradation
R4078 T5127 T5128 themeOf RPS3,association
R4079 T5128 T5126 themeOf association,required
R4080 T5129 T5130 themeOf IκBα,phosphorylation
R4081 T5129 T5131 themeOf IκBα,degradation
R4082 T5130 T5133 causeOf phosphorylation,cause
R4083 T5131 T5132 causeOf degradation,cause
R4084 T5134 T5135 themeOf RPS3,association
R4085 T5134 T5138 themeOf RPS3,translocation
R4086 T5135 T5136 causeOf association,followed
R4087 T5136 T5133 themeOf followed,cause
R4088 T5136 T5132 themeOf followed,cause
R4089 T5137 T5138 locationOf nuclear,translocation
R4090 T5138 T5136 themeOf translocation,followed
R4091 T5141 T5140 themeOf RPS3,phosphorylation
R5588 T7051 T7052 causeOf IKKβ,phosphorylates
R5589 T7054 T7052 themeOf serine 209,phosphorylates
R5590 T7054 T7053 partOf serine 209,RPS3
R5591 T7055 T7057 causeOf IKKβ,phosphorylates
R5592 T7055 T7056 causeOf IKKβ,phosphorylates
R5593 T7058 T7057 themeOf 14-3-3β,phosphorylates
R5594 T7059 T7056 themeOf Bcl10,phosphorylates
R5595 T7060 T7061 causeOf IKKβ,phosphorylate
R5596 T7062 T7061 themeOf RPS3,phosphorylate
R5597 T7068 T7064 themeOf IKKα,incorporation of 32P
R5598 T7068 T7067 themeOf IKKα,autophosphorylatd
R5599 T7069 T7065 themeOf IKKβ,incorporation of 32P
R5600 T7069 T7066 themeOf IKKβ,autophosphorylatd
R5601 T7072 T7070 themeOf GST-IκBα,phosporylated
R5602 T7073 T7071 themeOf GST,phosporylated
R5603 T7076 T7078 themeOf GST-RPS3,phosphorylated
R5604 T7076 T7077 themeOf GST-RPS3,phosphorylated
R5605 T7079 T7078 causeOf IKKβ,phosphorylated
R5606 T7080 T7077 causeOf IKKα,phosphorylated
R5607 T7082 T7083 themeOf amino acid residue(s),phosphorylated
R5608 T7082 T7081 partOf amino acid residue(s),RPS3
R5609 T7084 T7083 causeOf IKKβ,phosphorylated
R5610 T7086 T7085 themeOf RPS3,phosphorylated
R5611 T7087 T7088 causeOf IKKβ,phosphorylated
R5612 T7089 T7088 themeOf S209,phosphorylated
R5613 T7089 T7090 partOf S209,RPS3
R5614 T7094 T7095 themeOf S209A,mutant
R5615 T7094 T7096 partOf S209A,RPS3
R5616 T7097 T7098 themeOf S209A,mutation
R5617 T7097 T7102 partOf S209A,RPS3
R5618 T7098 T7099 causeOf mutation,reduced
R5619 T7100 T7101 causeOf IKKβ–,mediated
R5620 T7101 T7099 themeOf mediated,reduced
R5621 T7102 T7103 themeOf RPS3,phosphorylation
R5622 T7103 T7101 themeOf phosphorylation,mediated
R5623 T7105 T7104 themeOf RPS3,phosphorylated
R5624 T7107 T7108 themeOf sequence motif,recognized
R5625 T7107 T7106 partOf sequence motif,RPS3
R5626 T7111 T7112 themeOf S209,phosphorylation
R5627 T7111 T7110 partOf S209,RPS3
R5628 T7112 T7113 themeOf phosphorylation,due
R5629 T7114 T7113 causeOf IKKβ,due
R5630 T7115 T7116 causeOf S209,critical
R5631 T7115 T7119 partOf S209,RPS3
R5632 T7117 T7118 causeOf IKKβ,phosphorylates
R5633 T7118 T7116 themeOf phosphorylates,critical
R5634 T7119 T7118 themeOf RPS3,phosphorylates
R5635 T7122 T7120 themeOf Flag-RPS3,transfected
R5636 T7123 T7121 themeOf IKKβ,transfected
R5637 T7124 T7126 causeOf overexpressing,enhanced
R5638 T7125 T7124 themeOf IKKβ,overexpressing
R5639 T7127 T7128 themeOf Flag-RPS3,phosphorylation
R5640 T7128 T7126 themeOf phosphorylation,enhanced
R5641 T7128 T7129 themeOf phosphorylation,eliminated
R5642 T7130 T7129 causeOf alanine substitution,eliminated
R5643 T7131 T7130 themeOf S209,alanine substitution
R5644 T7131 T7127 partOf S209,Flag-RPS3
R5645 T7131 T7133 themeOf S209,phosphorylation
R5646 T7136 T7138 themeOf phosphorylated,dependent
R5647 T7137 T7136 themeOf S209,phosphorylated
R5648 T7137 T7135 partOf S209,RPS3
R5649 T7138 T7139 themeOf dependent,upon
R7172 T9003 T9002 themeOf RPS3,Phosphorylation
R7173 T9004 T9005 themeOf S209,phosphorylation
R7174 T9004 T9009 partOf S209,RPS3
R7176 T9007 T9008 locationOf nuclear,translocation
R7177 T9008 T9006 themeOf translocation,plays a role
R7179 T9010 T9011 themeOf S209A,mutant
R7180 T9010 T9012 partOf S209A,RPS3
R7181 T9014 T9016 themeOf Flag-RPS3,translocation
R7182 T9015 T9016 locationOf nuclear,translocation
R7183 T9016 T9013 themeOf translocation,triggered
R7184 T9017 T9020 themeOf RPS3,translocation
R7185 T9018 T9021 causeOf S209A,attenuated
R7186 T9018 T9017 partOf S209A,RPS3
R7187 T9019 T9020 locationOf nuclear,translocation
R7188 T9020 T9021 themeOf translocation,attenuated
R7189 T9024 T9023 themeOf IKKβ,overexpressing
R7190 T9025 T9027 themeOf RPS3,translocation
R7191 T9026 T9027 locationOf nuclear,translocation
R7192 T9027 T9022 themeOf translocation,impact
R7193 T9031 T9032 locationOf nuclear,translocation
R7194 T9032 T9030 themeOf translocation,induced
R7195 T9033 T9032 themeOf RPS3,translocation
R7196 T9034 T9035 themeOf S209,phosphorylation
R7197 T9034 T9038 partOf S209,RPS3
R7198 T9035 T9036 causeOf phosphorylation,critical
R7199 T9037 T9036 themeOf induced,critical
R7200 T9038 T9040 themeOf RPS3,translocation
R7201 T9039 T9040 locationOf nuclear,translocation
R7202 T9040 T9037 themeOf translocation,induced
R7203 T9041 T9042 themeOf S209,phosphorylation
R7204 T9041 T9043 partOf S209,RPS3
R7205 T9045 T9046 themeOf RPS3,expression
R7206 T9046 T9044 themeOf expression,silenced
R7207 T9048 T9049 themeOf RPS3,transfection
R7208 T9050 T9051 causeOf RPS3 siRNA,reduced
R7209 T9050 T9053 causeOf RPS3 siRNA,affect
R7210 T9052 T9051 themeOf RPS3,reduced
R7211 T9054 T9053 themeOf expression,affect
R7212 T9055 T9054 themeOf Flag-tagged RPS3,expression
R7213 T9056 T9057 themeOf RPS3,knockdown
R7214 T9057 T9058 causeOf knockdown,reduced
R7215 T9059 T9058 themeOf induced,reduced
R7216 T9060 T9059 themeOf expression,induced
R7217 T9062 T9060 themeOf luciferase,expression
R7218 T9062 T9061 themeOf luciferase,driven
R7219 T9063 T9065 themeOf impaired,caused
R7220 T9064 T9063 themeOf luciferase,impaired
R7221 T9066 T9067 themeOf RPS3,deficiency
R7222 T9067 T9065 causeOf deficiency,caused
R7223 T9069 T9068 themeOf RPS3,transfecting
R7224 T9071 T9070 themeOf green fluorescent protein,overexpression
R7225 T9072 T9071 equivalentTo GFP,green fluorescent protein
R7226 T9075 T9076 themeOf S209,phosphorylation
R7227 T9075 T9074 partOf S209,RPS3
R7228 T9077 T9078 themeOf S209,phosphorylation
R7229 T9077 T9081 partOf S209,RPS3
R7230 T9078 T9079 causeOf phosphorylation,affects
R7231 T9078 T9080 causeOf phosphorylation,affects
R7232 T9081 T9083 themeOf RPS3,recruitment
R7233 T9082 T9084 themeOf p65,recruitment
R7234 T9083 T9079 themeOf recruitment,affects
R7235 T9084 T9080 themeOf recruitment,affects
R7236 T9085 T9086 themeOf RPS3,knockdown
R7237 T9091 T9089 themeOf recruitment,stimulated
R7238 T9092 T9090 themeOf recruitment,stimulated
R7239 T9093 T9087 themeOf recruitment,stimulated
R7240 T9094 T9088 themeOf recruitment,stimulated
R7241 T9096 T9094 themeOf S209A,recruitment
R7242 T9096 T9097 partOf S209A,RPS3
R7243 T9096 T9091 themeOf S209A,recruitment
R7244 T9097 T9093 themeOf RPS3,recruitment
R7245 T9097 T9092 themeOf RPS3,recruitment
R7246 T9097 T9095 themeOf RPS3,expressed
R7247 T9098 T9094 themeOf κB sites,recruitment
R7248 T9098 T9099 partOf κB sites,NFKBIA
R7249 T9098 T9093 themeOf κB sites,recruitment
R7250 T9098 T9091 themeOf κB sites,recruitment
R7251 T9098 T9100 partOf κB sites,IL8
R7252 T9098 T9092 themeOf κB sites,recruitment
R7253 T9102 T9103 causeOf S209A,impact
R7254 T9102 T9101 partOf S209A,RPS3
R7255 T9102 T9107 causeOf S209A,attenuated
R7256 T9104 T9106 themeOf p65,translocation
R7257 T9105 T9106 locationOf nuclear,translocation
R7258 T9106 T9103 themeOf translocation,impact
R7259 T9108 T9109 themeOf p65,recruitment
R7260 T9109 T9107 themeOf recruitment,attenuated
R7261 T9110 T9111 themeOf p65,attraction
R7263 T9111 T9115 themeOf attraction,increased
R7264 T9113 T9111 locationOf promoters,attraction
R7265 T9116 T9118 themeOf Flag-RPS3,recruitment
R7266 T9117 T9119 themeOf p65,recruitment
R7268 T9121 T9118 locationOf promoter,recruitment
R7273 T9127 T9123 locationOf promoters,recruitment
R7274 T9127 T9125 locationOf promoters,recruitment
R7275 T9130 T9128 causeOf S209,depended
R7276 T9130 T9124 partOf S209,RPS3
R7277 T9130 T9129 causeOf S209,depended
R7278 T9131 T9133 themeOf Interleukin 8,secretion
R7279 T9131 T9135 themeOf Interleukin 8,stimulation
R7280 T9132 T9131 equivalentTo IL-8,Interleukin 8
R7281 T9133 T9134 themeOf secretion,induced
R7282 T9134 T9136 themeOf induced,decreased
R7283 T9135 T9134 causeOf stimulation,induced
R7284 T9137 T9136 causeOf reduced,decreased
R7285 T9138 T9140 themeOf RPS3,recruitment
R7286 T9140 T9137 themeOf recruitment,reduced
R7287 T9142 T9140 themeOf κB sites,recruitment
R7288 T9142 T9141 partOf κB sites,IL8
R7289 T9143 T9137 causeOf S209A,reduced
R7290 T9143 T9144 partOf S209A,RPS3
R7291 T9145 T9146 themeOf CD25,expression
R7292 T9147 T9148 themeOf RPS3,transfected
R7293 T9150 T9151 themeOf S209,phosphorylation
R7294 T9150 T9149 partOf S209,RPS3
R7295 T9151 T9152 themeOf phosphorylation,by
R7296 T9153 T9152 causeOf IKKβ,by
R9503 T11830 T11831 causeOf NleH1,inhibits
R9504 T11832 T11833 themeOf RPS3,phosphorylation
R9505 T11833 T11831 themeOf phosphorylation,inhibits
R9506 T11834 T11835 themeOf NleH1,binds
R9507 T11835 T11836 causeOf binds,attenuates
R9509 T11837 T11835 themeOf RPS3,binds
R9511 T11839 T11836 themeOf translocation,attenuates
R9512 T11841 T11842 causeOf NleH1,inhibiting
R9513 T11844 T11845 themeOf S209,phosphorylation
R9514 T11844 T11843 partOf S209,RPS3
R9516 T11847 T11846 themeOf NleH1-HA,increasing
R9517 T11849 T11851 causeOf NleH1,reduced
R9518 T11849 T11850 causeOf NleH1,reduced
R9519 T11852 T11853 causeOf TNF,induced
R9520 T11853 T11851 themeOf induced,reduced
R9521 T11854 T11855 themeOf RPS3,phosphorylation
R9522 T11855 T11853 themeOf phosphorylation,induced
R9523 T11855 T11850 themeOf phosphorylation,reduced
R9524 T11856 T11859 causeOf Expressing,interfere
R9525 T11856 T11861 themeOf Expressing,activation
R9526 T11856 T11858 causeOf Expressing,interfere
R9527 T11857 T11856 themeOf NleH1,Expressing
R9528 T11860 T11861 causeOf TNF,activation
R9529 T11861 T11859 themeOf activation,interfere
R9530 T11862 T11863 themeOf IκBα,degradation
R9531 T11863 T11858 themeOf degradation,interfere
R9532 T11864 T11866 causeOf lack,impact
R9533 T11865 T11864 themeOf NleH1,lack
R9534 T11867 T11869 themeOf p65,translocation
R9535 T11868 T11869 locationOf nuclear,translocation
R9536 T11869 T11866 themeOf translocation,impact
R9537 T11870 T11871 causeOf NleH1,inhibits
R9538 T11872 T11873 themeOf RPS3,phosphorylation
R9539 T11873 T11871 themeOf phosphorylation,inhibits
R9540 T11875 T11874 themeOf nleH1,lacking
R9541 T11879 T11880 causeOf TNF,increase
R9542 T11882 T11883 themeOf S209,phosphorylation
R9543 T11882 T11881 partOf S209,RPS3
R9544 T11883 T11880 themeOf phosphorylation,increase
R9545 T11885 T11886 themeOf S209,phosphorylation
R9546 T11885 T11884 partOf S209,RPS3
R9547 T11886 T11887 themeOf phosphorylation,impaired
R9548 T11888 T11889 causeOf TNF,induced
R9549 T11889 T11893 themeOf induced,unimpaired
R9550 T11889 T11894 themeOf induced,unimpaired
R9551 T11891 T11892 themeOf S209,phosphorylation
R9552 T11891 T11890 partOf S209,RPS3
R9553 T11892 T11889 themeOf phosphorylation,induced
R9554 T11895 T11893 causeOf ΔnleH1,unimpaired
R9555 T11896 T11894 causeOf ΔescN,unimpaired
R9556 T11897 T11899 causeOf ΔnleH1,attenuated
R9557 T11898 T11900 causeOf ΔescN,attenuated
R9558 T11901 T11902 causeOf TNF,induced
R9559 T11902 T11899 themeOf induced,attenuated
R9560 T11902 T11900 themeOf induced,attenuated
R9561 T11903 T11905 themeOf RPS3,translocation
R9562 T11904 T11905 locationOf nuclear,translocation
R9563 T11905 T11902 themeOf translocation,induced
R9564 T11906 T11907 themeOf RPS3,phosphorylation
R9565 T11906 T11909 themeOf RPS3,translocation
R9566 T11908 T11909 locationOf nuclear,translocation
R9567 T11910 T11915 themeOf RPS3,translocation
R9568 T11911 T11912 themeOf S209,phosphorylation
R9569 T11911 T11910 partOf S209,RPS3
R9570 T11912 T11913 causeOf phosphorylation,important
R9571 T11914 T11915 locationOf nuclear,translocation
R9572 T11915 T11913 themeOf translocation,important
R9573 T11916 T11917 causeOf NleH1,inhibits
R9574 T11919 T11920 themeOf S209,phosphorylation
R9575 T11919 T11918 partOf S209,RPS3
R9576 T11920 T11917 themeOf phosphorylation,inhibits
R9577 T11928 T11927 themeOf nleH1,deleting
R9578 T11931 T11932 causeOf NleH1,blocking
R9579 T11934 T11935 themeOf S209,phosphorylation
R9580 T11934 T11933 partOf S209,RPS3
R9581 T11935 T11932 themeOf phosphorylation,blocking
R11014 T13731 T13728 themeOf phosphorylation,inhibits
R11015 T13734 T13735 causeOf NleH1,blocked
R11016 T13735 T13739 causeOf blocked,preventing
R11017 T13737 T13738 themeOf S209,phosphorylation
R11018 T13737 T13736 partOf S209,RPS3
R11019 T13738 T13735 themeOf phosphorylation,blocked
R11020 T13740 T13742 themeOf RPS3,translocation
R11021 T13741 T13742 locationOf nuclear,translocation
R11022 T13742 T13739 themeOf translocation,preventing
R11023 T13744 T13743 themeOf phospho,low
R11024 T13745 T13744 themeOf RPS3,phospho
R11025 T13746 T13749 causeOf ΔnleH1,intense
R11026 T13747 T13749 themeOf phospho,intense
R11027 T13748 T13747 themeOf RPS3,phospho
R11028 T13750 T13751 causeOf NleH1,inhibits
R11029 T13753 T13754 themeOf S209,phosphorylation
R11030 T13753 T13752 partOf S209,RPS3
R11031 T13754 T13751 themeOf phosphorylation,inhibits
R11787 T14711 T14712 themeOf NleH1,autophosphorylated
R11788 T14712 T14713 themeOf autophosphorylated,depends
R11789 T14714 T14713 causeOf lysine 159,depends
R11790 T14714 T14711 partOf lysine 159,NleH1
R11793 T14718 T14717 partOf S209,RPS3
R11794 T14719 T14716 themeOf phosphorylation,inhibits
R11795 T14722 T14723 themeOf NleH1,autophosphorylated
R11796 T14724 T14726 causeOf K159A,kinase-dead
R11797 T14724 T14725 partOf K159A,NleH1
R11798 T14725 T14726 themeOf NleH1,kinase-dead
R11799 T14729 T14727 themeOf inhibit,required
R11800 T14731 T14729 themeOf phosphorlyation,inhibit
R11801 T14733 T14731 themeOf S209,phosphorlyation
R11802 T14733 T14732 partOf S209,RPS3
R11803 T14735 T14736 themeOf NleH1,expression
R11804 T14736 T14737 causeOf expression,reduced
R11805 T14737 T14742 themeOf reduced,failed
R11806 T14738 T14737 themeOf induced,reduced
R11807 T14740 T14741 themeOf S209,phosphorylation
R11808 T14740 T14739 partOf S209,RPS3
R11809 T14741 T14738 themeOf phosphorylation,induced
R11810 T14745 T14744 themeOf protect,required
R11811 T14746 T14749 themeOf RPS3,phosphorylation
R11812 T14747 T14748 causeOf IKKβ,mediated
R11813 T14748 T14745 themeOf mediated,protect
R11814 T14749 T14748 themeOf phosphorylation,mediated
R11815 T14750 T14751 causeOf NleH,inhibited
R11816 T14750 T14752 causeOf NleH,inhibited
R11817 T14753 T14755 themeOf RPS3,translocation
R11818 T14754 T14755 locationOf nuclear,translocation
R11819 T14755 T14751 themeOf translocation,inhibited
R11820 T14756 T14757 causeOf RPS3,dependent
R11821 T14757 T14752 themeOf dependent,inhibited
R11822 T14758 T14759 themeOf luciferase,activity
R11823 T14759 T14757 themeOf activity,dependent
R11824 T14762 T14763 themeOf S209,phosphorylation
R11825 T14762 T14761 partOf S209,RPS3
R11826 T14766 T14767 themeOf S209,phosphorylation
R11827 T14766 T14765 partOf S209,RPS3
R11828 T14767 T14764 themeOf phosphorylation,increase
R11829 T14768 T14771 themeOf augmentation,reduced
R11830 T14769 T14770 themeOf RPS3,phosphorylation
R11831 T14770 T14768 themeOf phosphorylation,augmentation
R11832 T14772 T14773 themeOf RPS3,phosphorylation
R11833 T14773 T14774 themeOf phosphorylation,enhanced
R11834 T14775 T14774 causeOf lacking,enhanced
R11835 T14776 T14775 themeOf NleH,lacking
R11836 T14781 T14780 themeOf NleH1,express
R11837 T14783 T14784 causeOf NleH1,abolished
R11838 T14785 T14786 causeOf TNF,induced
R11839 T14786 T14784 themeOf induced,abolished
R11840 T14788 T14789 themeOf S209,phosphorylation
R11841 T14788 T14787 partOf S209,RPS3
R11842 T14789 T14786 themeOf phosphorylation,induced
R11843 T14791 T14792 themeOf RPS3,phosphorylation
R11844 T14792 T14790 themeOf phosphorylation,inhibit
R11845 T14795 T14794 themeOf block,required
R11846 T14795 T14800 causeOf block,impair
R11847 T14797 T14798 themeOf S209,phosphorylation
R11848 T14797 T14796 partOf S209,RPS3
R11849 T14798 T14795 themeOf phosphorylation,block
R11850 T14801 T14802 locationOf nuclear,translocation
R11851 T14802 T14804 themeOf translocation,trigged
R11852 T14803 T14802 themeOf RPS3,translocation
R11853 T14804 T14800 themeOf trigged,impair
R11854 T14806 T14804 causeOf IKKβ,trigged
R11855 T14806 T14805 themeOf IKKβ,constitutively-active
R11856 T14807 T14808 themeOf IKKβ,SSEE
R11857 T14809 T14810 causeOf SSEE IKKβ,triggered
R11858 T14811 T14813 themeOf RPS3,translocation
R11859 T14812 T14813 locationOf nuclear,translocation
R11860 T14813 T14810 themeOf translocation,triggered
R11861 T14815 T14814 themeOf IKKβ,kinase-dead
R11862 T14815 T14816 themeOf IKKβ,SSAA
R11863 T14817 T14819 themeOf RPS3,accumulation
R11864 T14818 T14819 locationOf nuclear,accumulation
R11865 T14819 T14820 themeOf accumulation,retarded
R11866 T14823 T14825 themeOf RPS3,translocation
R11867 T14824 T14825 locationOf nuclear,translocation
R11868 T14826 T14830 themeOf IKKβ,expressing
R11869 T14827 T14828 themeOf IKKβ,SSEE
R11870 T14827 T14829 themeOf IKKβ,expressing
R11871 T14832 T14834 themeOf RPS3,translocation
R11872 T14833 T14834 locationOf nuclear,translocation
R11873 T14834 T14831 themeOf translocation,affect
R11874 T14835 T14836 themeOf IKKβ,SSAA
R11875 T14835 T14837 themeOf IKKβ,expressing
R11876 T14838 T14839 causeOf NleH1,inhibit
R11877 T14840 T14842 themeOf RPS3,translocation
R11878 T14841 T14842 locationOf nuclear,translocation
R11879 T14842 T14839 themeOf translocation,inhibit
R11880 T14845 T14843 themeOf IKKβ,expressing
R11881 T14845 T14844 themeOf IKKβ,activated
R11882 T14846 T14850 causeOf NleH1,inhibiting
R11883 T14847 T14849 causeOf phosphorylate,thus
R11884 T14848 T14847 themeOf IKKβ,phosphorylate
R11885 T14850 T14849 themeOf inhibiting,thus
R11886 T14851 T14852 causeOf IKKβ,mediated
R11887 T14852 T14850 themeOf mediated,inhibiting
R11888 T14854 T14855 themeOf S209,phosphorylation
R11889 T14854 T14853 partOf S209,RPS3
R11890 T14855 T14852 themeOf phosphorylation,mediated
R11891 T14858 T14859 themeOf IKKβ,autophosphorylation
R11892 T14858 T14861 themeOf IKKβ,phosphorylation
R11893 T14863 T14862 themeOf IKKβ,32P incorporation
R11894 T14867 T14868 causeOf IKKβ,phosphorylated
R11895 T14867 T14869 causeOf IKKβ,phosphorylated
R11896 T14870 T14868 themeOf RPS3,phosphorylated
R11897 T14870 T14872 themeOf RPS3,substrate specificity
R11898 T14871 T14869 themeOf GST-IκBα,phosphorylated
R11899 T14874 T14875 causeOf NleH1,reduced
R11900 T14874 T14876 causeOf NleH1,reduced
R11901 T14877 T14878 causeOf IKKβ,mediated
R11902 T14878 T14875 themeOf mediated,reduced
R11903 T14879 T14880 themeOf RPS3,phosphorylation
R11904 T14880 T14878 themeOf phosphorylation,mediated
R11905 T14881 T14882 causeOf IKKβ,mediated
R11906 T14882 T14876 themeOf mediated,reduced
R11907 T14883 T14884 themeOf GST-IκBα,phosphorylation
R11908 T14884 T14882 themeOf phosphorylation,mediated
R11909 T14885 T14888 causeOf NleH1,mediated
R11910 T14885 T14889 causeOf NleH1,mediated
R11911 T14885 T14887 causeOf NleH1,mediated
R11912 T14885 T14886 causeOf NleH1,mediated
R11913 T14890 T14889 themeOf phosphorylation,mediated
R11914 T14891 T14888 themeOf phosphorylation,mediated
R11915 T14892 T14886 themeOf autophosphorylation,mediated
R11916 T14893 T14887 themeOf autophosphorylation,mediated
R11917 T14894 T14891 themeOf RPS3,phosphorylation
R11918 T14894 T14893 themeOf RPS3,autophosphorylation
R11919 T14895 T14890 themeOf GST-IκBα,phosphorylation
R11920 T14895 T14892 themeOf GST-IκBα,autophosphorylation
R11921 T14899 T14900 causeOf IKKβ,mediated
R11922 T14900 T14898 themeOf mediated,inhibiting
R11923 T14902 T14903 themeOf S209,phosphorylation
R11924 T14902 T14901 partOf S209,RPS3
R11925 T14903 T14900 themeOf phosphorylation,mediated
R14344 T18035 T18036 themeOf RPS3,translocate
R14345 T18036 T18034 themeOf translocate,triggers
R14346 T18037 T18036 locationOf nucleus,translocate
R14347 T18038 T18039 causeOf IKKβ,mediated
R14348 T18039 T18043 causeOf mediated,critical
R14349 T18040 T18045 themeOf RPS3,import
R14350 T18041 T18042 themeOf S209,phosphorylation
R14351 T18041 T18040 partOf S209,RPS3
R14352 T18042 T18039 themeOf phosphorylation,mediated
R14353 T18044 T18045 locationOf nuclear,import
R14354 T18045 T18043 themeOf import,critical
R14355 T18049 T18051 causeOf IKKβ,phosphorylated
R14356 T18050 T18052 causeOf IKKα,phosphorylated
R14357 T18051 T18055 causeOf phosphorylated,modulation
R14358 T18052 T18054 causeOf phosphorylated,modulation
R14359 T18053 T18051 themeOf RPS3,phosphorylated
R14360 T18053 T18052 themeOf RPS3,phosphorylated
R14361 T18056 T18058 themeOf RPS3,translocation
R14362 T18057 T18058 locationOf nuclear,translocation
R14363 T18058 T18055 themeOf translocation,modulation
R14364 T18058 T18054 themeOf translocation,modulation
R14365 T18058 T18059 themeOf translocation,via
R14366 T18061 T18060 themeOf p65,phosphorylate
R14367 T18064 T18062 themeOf IKKβ,bind
R14368 T18064 T18063 themeOf IKKβ,phosphorylate
R14369 T18065 T18066 themeOf IKKβ,bound
R14370 T18066 T18067 causeOf bound,account for
R14371 T18068 T18069 themeOf RPS3,phosphorylation
R14372 T18069 T18067 themeOf phosphorylation,account for
R14373 T18073 T18074 causeOf IKKβ,mediated
R14374 T18074 T18078 themeOf mediated,modulated
R14375 T18076 T18077 themeOf S209,phosphorylation
R14376 T18076 T18075 partOf S209,RPS3
R14377 T18077 T18074 themeOf phosphorylation,mediated
R14378 T18079 T18080 themeOf NleH1,binds
R14379 T18081 T18080 themeOf RPS3,binds
R14380 T18082 T18083 causeOf NleH1,inhibits
R14381 T18083 T18086 causeOf inhibits,retarding
R14382 T18084 T18085 themeOf RPS3,phosphorylation
R14383 T18084 T18088 themeOf RPS3,translocation
R14384 T18085 T18083 themeOf phosphorylation,inhibits
R14385 T18087 T18088 locationOf nuclear,translocation
R14386 T18088 T18086 themeOf translocation,retarding
R14387 T18091 T18090 themeOf IKKβ,phosphorylate
R14388 T18093 T18094 causeOf IKKβ,mediated
R14389 T18094 T18092 themeOf mediated,inhibit
R14390 T18096 T18097 themeOf S209,phosphorylation
R14391 T18096 T18095 partOf S209,RPS3
R14392 T18097 T18094 themeOf phosphorylation,mediated
R14393 T18098 T18099 causeOf NleH1,steer
R14394 T18100 T18099 themeOf IKKβ,steer
R14395 T18104 T18105 causeOf NleH1,block
R14396 T18106 T18108 themeOf p65,translocation
R14397 T18107 T18108 locationOf nuclear,translocation
R14398 T18108 T18105 themeOf translocation,block
R14399 T18112 T18111 themeOf RPS3,inhibiting
R14400 T18113 T18111 causeOf NleH1,inhibiting
R14401 T18115 T18114 themeOf RPS3,impeding
R14402 T18117 T18119 themeOf p65,translocation
R14403 T18118 T18119 locationOf nuclear,translocation
R14404 T18119 T18116 themeOf translocation,altering
R14405 T18121 T18120 themeOf RPS3,effects
R1568 T1983 T1984 themeOf RPS3,phosphorylation
R1569 T1984 T1985 themeOf phosphorylation,in response to
R1570 T1986 T1987 themeOf RPS3,phosphorylated
R7175 T9005 T9006 causeOf phosphorylation,plays a role
R7178 T9009 T9008 themeOf RPS3,translocation
R7262 T9111 T9122 themeOf attraction,specific
R7267 T9121 T9119 locationOf promoter,recruitment
R7269 T9123 T9128 themeOf recruitment,depended
R7270 T9124 T9123 themeOf RPS3,recruitment
R7271 T9125 T9129 themeOf recruitment,depended
R7272 T9126 T9125 themeOf p65,recruitment
R11791 T14715 T14716 causeOf NleH1,inhibits
R11792 T14718 T14719 themeOf S209,phosphorylation
R9508 T11837 T11839 themeOf RPS3,translocation
R9510 T11838 T11839 locationOf nuclear,translocation
R9515 T11845 T11842 themeOf phosphorylation,inhibiting
R11011 T13727 T13728 causeOf NleH1,inhibits
R11012 T13730 T13731 themeOf S209,phosphorylation
R11013 T13730 T13729 partOf S209,RPS3

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T33 0-4 Protein denotes IKKβ
T34 5-20 Phosphorylation denotes phosphorylation
T35 21-30 Regulation denotes regulates
T36 31-35 Protein denotes RPS3
T37 36-43 Entity denotes nuclear true
T38 44-57 Localization denotes translocation
T39 186-206 Protein denotes ribosomal protein S3
T40 208-212 Protein denotes RPS3
T41 303-307 Protein denotes RPS3
T42 308-315 Entity denotes nuclear
T43 316-329 Localization denotes translocation
T44 333-342 Regulation denotes regulated
T45 364-368 Protein denotes IKKβ
T46 369-384 Phosphorylation denotes phosphorylation
T47 388-398 Entity denotes serine 209
T48 410-417 Positive_regulation denotes crucial
T49 422-426 Protein denotes RPS3
T50 427-434 Entity denotes nuclear
T51 435-447 Localization denotes localization
T52 448-462 Positive_regulation denotes in response to
T53 559-564 Protein denotes NleH1
T54 578-587 Negative_regulation denotes inhibited
T55 588-592 Protein denotes RPS3
T56 593-597 Entity denotes S209
T57 598-613 Phosphorylation denotes phosphorylation
T58 618-625 Negative_regulation denotes blocked
T59 626-630 Protein denotes RPS3
T60 771-775 Protein denotes IKKβ
T61 827-831 Protein denotes RPS3
T676 1203-1207 Protein denotes RelA
T677 1209-1212 Protein denotes p65
T678 1215-1219 Protein denotes RelB
T679 1221-1226 Protein denotes c-Rel true
T680 1228-1231 Protein denotes p50
T681 1237-1240 Protein denotes p52 true
T682 1294-1314 Protein denotes ribosomal protein S3
T683 1316-1320 Protein denotes RPS3
T684 1335-1338 Protein denotes Rel true
T685 1383-1387 Protein denotes RPS3 true
T686 1564-1568 Protein denotes RPS3
T687 1636-1664 Protein denotes immunoglobulin κ light chain
T688 1670-1680 Gene_expression denotes expression
T689 1908-1913 Protein denotes NleH1
T690 1968-1979 Negative_regulation denotes attenuating
T691 1980-1984 Protein denotes RPS3
T692 1985-1992 Entity denotes nuclear
T693 1993-2006 Localization denotes translocation
T694 2016-2025 Regulation denotes affecting
T695 2026-2029 Protein denotes p65
T696 2030-2043 Localization denotes localization9
T697 2096-2102 Positive_regulation denotes induce
T698 2103-2107 Protein denotes RPS3
T699 2108-2115 Entity denotes nuclear
T700 2116-2129 Localization denotes translocation
T701 2220-2227 Binding denotes binding
T702 2266-2270 Protein denotes RPS3
T703 2271-2283 Binding denotes participates
T704 2353-2357 Protein denotes RPS3
T705 2361-2375 Phosphorylation denotes phosphorylated
T706 2487-2491 Protein denotes RPS3
T707 2495-2509 Phosphorylation denotes phosphorylated
T708 2672-2676 Protein denotes RPS3
T709 2727-2760 Protein denotes Inhibitor of κB (IκB) kinase beta
T710 2762-2766 Protein denotes IKKβ
T711 2768-2782 Phosphorylation denotes phosphorylated
T712 2783-2787 Protein denotes RPS3
T713 2791-2801 Entity denotes serine 209
T714 2810-2814 Protein denotes RPS3
T715 2815-2819 Entity denotes S209
T716 2820-2835 Phosphorylation denotes phosphorylation
T717 2836-2844 Positive_regulation denotes enhanced
T718 2849-2860 Binding denotes association
T719 2878-2887 Positive_regulation denotes mediating
T720 2888-2892 Protein denotes RPS3
T721 2893-2898 Binding denotes entry
T722 2932-2939 Entity denotes nuclear
T723 2940-2953 Localization denotes translocation
T724 2975-2985 Protein denotes coli NleH1
T725 3008-3017 Negative_regulation denotes inhibited
T726 3018-3022 Protein denotes RPS3
T727 3023-3027 Entity denotes S209
T1962 3126-3130 Protein denotes RPS3
T1963 3131-3146 Phosphorylation denotes phosphorylation true
T1964 3195-3199 Protein denotes RPS3 true
T1965 3203-3217 Phosphorylation denotes phosphorylated true
T1966 3345-3349 Protein denotes RPS3
T1967 3363-3377 Phosphorylation denotes phosphorylated
T1968 3422-3430 Positive_regulation denotes increase true
T1969 3485-3493 Positive_regulation denotes increase true
T1970 3497-3501 Protein denotes RPS3
T1971 3540-3544 Protein denotes RPS3
T1972 3545-3553 Entity denotes residues
T1973 3559-3573 Phosphorylation denotes phosphorylated
T1974 3597-3601 Protein denotes RPS3
T1975 3770-3780 Positive_regulation denotes stimulated true
T1976 3787-3802 Phosphorylation denotes phosphorylation true
T1977 3821-3825 Protein denotes IκBα
T1978 3864-3868 Protein denotes RPS3
T1979 3869-3884 Phosphorylation denotes phosphorylation
T1980 3888-3894 Entity denotes serine
T1981 4008-4023 Phosphorylation denotes phosphorylation
T1982 4027-4031 Protein denotes RPS3
T2568 4044-4048 Protein denotes RPS3 true
T2569 4053-4057 Protein denotes IKKβ
T2570 4058-4069 Binding denotes interaction true
T2571 4157-4161 Protein denotes IKKγ true
T2572 4190-4194 Protein denotes IKKα
T2573 4199-4203 Protein denotes IKKβ
T2574 4208-4216 Positive_regulation denotes critical
T2575 4322-4326 Protein denotes RPS3
T2576 4359-4362 Protein denotes p65
T2577 4363-4366 Protein denotes p50
T2578 4367-4371 Protein denotes IκBα
T2579 4431-4440 Positive_regulation denotes activated true
T2580 4441-4445 Protein denotes IKKβ
T2581 4457-4461 Binding denotes bind
T2582 4469-4482 Phosphorylation denotes phosphorylate
T2583 4483-4487 Protein denotes RPS3
T2584 4522-4531 Gene_expression denotes expressed
T2585 4532-4536 Protein denotes IKKβ
T2586 4541-4545 Protein denotes RPS3
T2587 4546-4556 Binding denotes interacted
T2588 4639-4643 Protein denotes IKKβ
T2589 4644-4648 Protein denotes RPS3
T2590 4649-4660 Binding denotes interaction
T2591 4775-4779 Protein denotes RPS3
T2592 4780-4784 Protein denotes IKKβ
T2593 4785-4796 Binding denotes association
T2594 4809-4818 Positive_regulation denotes augmented
T2595 4901-4905 Protein denotes RPS3
T2596 4906-4912 Entity denotes serine
T2597 4913-4928 Phosphorylation denotes phosphorylation
T2598 4977-4988 Binding denotes interaction
T2599 4997-5001 Protein denotes RPS3
T2600 5006-5010 Protein denotes IKKα
T3354 5023-5027 Protein denotes IKKβ
T3355 5031-5039 Positive_regulation denotes required
T3356 5044-5048 Protein denotes RPS3
T3357 5049-5056 Entity denotes nuclear true
T3358 5057-5070 Localization denotes translocation
T3359 5094-5098 Protein denotes RPS3
T3360 5099-5103 Protein denotes IKKβ
T3361 5104-5115 Binding denotes interaction
T3362 5119-5127 Positive_regulation denotes required
T3363 5132-5136 Protein denotes RPS3 true
T3364 5137-5144 Entity denotes nuclear
T3365 5145-5158 Localization denotes translocation
T3366 5163-5175 Negative_regulation denotes knocked down
T3367 5176-5180 Protein denotes IKKα
T3368 5184-5188 Protein denotes IKKβ
T3369 5189-5199 Gene_expression denotes expression
T3370 5265-5272 Positive_regulation denotes induced
T3371 5273-5277 Protein denotes RPS3
T3372 5278-5285 Entity denotes nuclear
T3373 5286-5295 Localization denotes migration
T3374 5339-5348 Positive_regulation denotes triggered
T3375 5349-5353 Protein denotes RPS3
T3376 5354-5361 Entity denotes nuclear true
T3377 5362-5375 Localization denotes translocation
T3378 5456-5460 Protein denotes RPS3 true
T3379 5461-5468 Entity denotes nuclear
T3380 5469-5482 Localization denotes translocation
T3381 5513-5521 Negative_regulation denotes impaired
T3382 5525-5529 Protein denotes IKKα true
T3383 5530-5539 Negative_regulation denotes silencing
T3384 5553-5562 Negative_regulation denotes knockdown
T3385 5566-5570 Protein denotes IKKβ
T3386 5571-5581 Negative_regulation denotes attenuated
T3387 5592-5596 Protein denotes RPS3
T3388 5597-5604 Entity denotes nuclear true
T3389 5605-5617 Localization denotes accumulation
T3390 5618-5627 Positive_regulation denotes following true
T3391 5707-5717 Gene_expression denotes expression
T3392 5721-5725 Protein denotes IKKβ
T3393 5735-5739 Protein denotes IKKα
T3394 5745-5754 Positive_regulation denotes necessary
T3395 5770-5777 Positive_regulation denotes induced
T3396 5778-5782 Protein denotes RPS3
T3397 5783-5790 Entity denotes nuclear
T3398 5791-5804 Localization denotes translocation true
T3399 5850-5853 Protein denotes p65
T3400 5854-5861 Entity denotes nuclear true
T3401 5862-5875 Localization denotes translocation
T3402 5880-5887 Negative_regulation denotes blocked
T3403 5946-5953 Entity denotes nuclear
T3404 5954-5967 Localization denotes translocation
T3405 5971-5975 Protein denotes RPS3
T3406 5997-6007 Gene_expression denotes expressing
T3407 6015-6026 Negative_regulation denotes kinase-dead
T3408 6037-6058 Positive_regulation denotes constitutively-active
T3409 6073-6077 Protein denotes IKKβ
T3410 6135-6139 Protein denotes IKKβ
T3411 6140-6147 Positive_regulation denotes induced
T3412 6154-6163 Regulation denotes dependent
T3413 6164-6174 Protein denotes luciferase
T3414 6218-6222 Protein denotes RPS3
T3415 6232-6241 Entity denotes cytosolic
T3416 6245-6249 Protein denotes IKKβ
T3417 6251-6255 Negative_regulation denotes SSAA
T3418 6257-6267 Gene_expression denotes expressing
T3419 6320-6324 Protein denotes RPS3
T3420 6325-6337 Localization denotes translocated
T3421 6345-6352 Entity denotes nucleus
T3422 6362-6372 Gene_expression denotes expressing
T3423 6373-6377 Protein denotes IKKβ
T3424 6457-6461 Protein denotes RPS3
T3425 6462-6471 Positive_regulation denotes increased
T3426 6482-6486 Protein denotes IKKβ
T3427 6494-6504 Gene_expression denotes expressing
T3428 6523-6527 Protein denotes IKKβ
T3429 6529-6533 Negative_regulation denotes SSAA
T3430 6535-6545 Gene_expression denotes expressing
T3431 6593-6597 Protein denotes IKKβ
T3432 6610-6619 Positive_regulation denotes necessary
T3433 6624-6634 Positive_regulation denotes sufficient
T3434 6639-6643 Protein denotes RPS3
T3435 6644-6651 Entity denotes nuclear
T3436 6652-6665 Localization denotes translocation
T3437 6666-6680 Positive_regulation denotes in response to
T4913 6708-6712 Protein denotes IκBα true
T4914 6713-6724 Protein_catabolism denotes degradation true
T4915 6729-6733 Protein denotes RPS3
T4916 6734-6741 Entity denotes nuclear
T4917 6742-6755 Localization denotes translocation
T4918 6767-6776 Regulation denotes regulates
T4919 6781-6788 Entity denotes nuclear
T4920 6789-6795 Localization denotes import
T4921 6805-6808 Protein denotes Rel
T4922 6825-6829 Protein denotes RPS3
T4923 6840-6847 Entity denotes nuclear
T4924 6848-6860 Localization denotes localization
T4925 6891-6898 Entity denotes nuclear
T4926 6899-6912 Localization denotes translocation
T4927 6958-6961 Protein denotes p65
T4928 6962-6976 Localization denotes translocation6 true
T4929 6997-7001 Protein denotes RPS3
T4930 7076-7080 Protein denotes RPS3 true
T4931 7081-7092 Binding denotes association
T4932 7134-7142 Positive_regulation denotes enhanced
T4933 7209-7213 Protein denotes RPS3
T4934 7214-7221 Binding denotes binding
T4935 7239-7248 Positive_regulation denotes essential
T4936 7253-7260 Entity denotes nuclear
T4937 7261-7274 Localization denotes translocation
T4938 7306-7310 Protein denotes IκBα
T4939 7311-7322 Protein_catabolism denotes degradation
T4940 7328-7340 Positive_regulation denotes prerequisite
T4941 7344-7350 Negative_regulation denotes unmask
T4942 7355-7358 Entity denotes NLS true
T4943 7362-7365 Protein denotes p65 true
T4944 7376-7380 Protein denotes RPS3
T4945 7385-7389 Protein denotes IκBα true
T4946 7390-7394 Binding denotes bind
T4947 7398-7401 Protein denotes p65
T4948 7459-7463 Protein denotes IκBα
T4949 7464-7475 Protein_catabolism denotes degradation
T4950 7479-7487 Positive_regulation denotes required true
T4951 7510-7514 Protein denotes RPS3 true
T4952 7532-7543 Binding denotes association
T4953 7547-7551 Protein denotes RPS3
T4954 7582-7596 Gene_expression denotes overexpressing true
T4955 7607-7611 Protein denotes IκBα
T4956 7618-7622 Protein denotes IκBα true
T4957 7631-7635 Negative_regulation denotes SSAA
T4958 7650-7654 Protein denotes IKKβ
T4959 7655-7662 Positive_regulation denotes induced true
T4960 7663-7678 Phosphorylation denotes phosphorylation
T4961 7683-7694 Protein_catabolism denotes degradation true
T4962 7705-7716 Gene_expression denotes transfected
T4963 7732-7736 Protein denotes IκBα
T4964 7754-7763 Positive_regulation denotes augmented
T4965 7768-7779 Binding denotes interaction
T4966 7783-7787 Protein denotes RPS3
T4967 7886-7890 Protein denotes RPS3
T4968 7902-7913 Binding denotes association
T4969 7918-7927 Negative_regulation denotes abolished
T4970 7951-7961 Protein_catabolism denotes degradable
T4971 7962-7966 Protein denotes IκBα
T4972 7997-8001 Protein denotes IκBα
T4973 8045-8049 Protein denotes RPS3
T4974 8050-8057 Entity denotes nuclear
T4975 8058-8071 Localization denotes translocation
T4976 8090-8094 Protein denotes RPS3
T4977 8106-8117 Binding denotes association
T4978 8122-8129 Entity denotes nuclear
T4979 8130-8134 Protein denotes RPS3
T4980 8141-8149 Negative_regulation denotes reducing
T4981 8150-8154 Protein denotes IκBα
T4982 8155-8165 Gene_expression denotes expression
T4983 8200-8205 Protein denotes siRNA
T4984 8219-8223 Protein denotes IκBα
T4985 8235-8243 Negative_regulation denotes depleted
T4986 8244-8248 Protein denotes IκBα
T4987 8301-8305 Protein denotes RPS3
T4988 8317-8328 Binding denotes association
T4989 8337-8346 Positive_regulation denotes augmented
T4990 8386-8390 Protein denotes RPS3
T4991 8391-8399 Localization denotes detected
T4992 8467-8473 Positive_regulation denotes induce
T4993 8474-8478 Protein denotes IκBα
T4994 8479-8490 Protein_catabolism denotes degradation
T4995 8546-8555 Positive_regulation denotes increased
T4996 8556-8567 Binding denotes association
T4997 8576-8580 Protein denotes RPS3
T4998 8635-8642 Entity denotes nuclear
T4999 8643-8655 Localization denotes accumulation
T5000 8659-8663 Protein denotes RPS3
T5001 8682-8686 Protein denotes IκBα
T5002 8687-8698 Protein_catabolism denotes degradation
T5003 8803-8811 Positive_regulation denotes promotes
T5004 8827-8838 Binding denotes association
T5005 8851-8860 Localization denotes transport
T5006 8864-8868 Protein denotes RPS3
T5007 8875-8879 Protein denotes IκBα
T5008 8880-8891 Protein_catabolism denotes degradation
T5009 8923-8932 Positive_regulation denotes following
T5010 8950-8958 Positive_regulation denotes required
T5011 8967-8971 Protein denotes RPS3
T5012 8983-8994 Binding denotes association
T5013 9049-9053 Protein denotes IκBα
T5014 9054-9069 Phosphorylation denotes phosphorylation
T5015 9074-9085 Protein_catabolism denotes degradation
T5016 9096-9104 Positive_regulation denotes required
T5017 9127-9132 Positive_regulation denotes cause
T5018 9133-9137 Protein denotes RPS3
T5019 9138-9149 Binding denotes association
T5020 9166-9174 Positive_regulation denotes followed
T5021 9178-9185 Entity denotes nuclear
T5022 9186-9199 Localization denotes translocation
T5023 9243-9247 Protein denotes IKKβ
T5024 9248-9263 Phosphorylation denotes phosphorylation
T5025 9267-9271 Protein denotes RPS3
T5026 9276-9284 Positive_regulation denotes required
T6969 9287-9291 Protein denotes IKKβ
T6970 9292-9306 Phosphorylation denotes phosphorylates
T6971 9307-9311 Protein denotes RPS3
T6972 9395-9399 Protein denotes IKKβ true
T6973 9405-9419 Phosphorylation denotes phosphorylates
T6974 9451-9458 Protein denotes 14-3-3β
T6975 9463-9468 Protein denotes Bcl10
T6976 9476-9480 Negative_regulation denotes lack
T6977 9552-9556 Protein denotes IKKβ true
T6978 9572-9585 Phosphorylation denotes phosphorylate true
T6979 9586-9590 Protein denotes RPS3 true
T6980 9644-9648 Protein denotes RPS3 true true
T6981 9702-9719 Phosphorylation denotes autophosphorylatd
T6982 9720-9724 Protein denotes IKKα
T6983 9729-9733 Protein denotes IKKβ
T6984 9766-9779 Phosphorylation denotes phosporylated
T6985 9780-9788 Protein denotes GST-IκBα
T6986 9832-9835 Protein denotes GST
T6987 9888-9892 Protein denotes IKKα
T6988 9896-9900 Protein denotes IKKβ
T6989 9930-9938 Protein denotes GST-RPS3
T6990 9948-9962 Phosphorylation denotes phosphorylated
T6991 9966-9970 Protein denotes IKKβ
T6992 9980-9984 Protein denotes IKKα true
T6993 10045-10049 Protein denotes RPS3 true
T6994 10050-10070 Entity denotes amino acid residue(s
T6995 10072-10086 Phosphorylation denotes phosphorylated
T6996 10090-10094 Protein denotes IKKβ
T6997 10180-10194 Phosphorylation denotes phosphorylated
T6998 10195-10199 Protein denotes RPS3
T6999 10228-10232 Protein denotes IKKβ
T7000 10233-10247 Phosphorylation denotes phosphorylated
T7001 10248-10252 Entity denotes S209
T7002 10269-10273 Protein denotes RPS3
T7003 10296-10300 Protein denotes RPS3
T7004 10345-10349 Entity denotes S209
T7005 10588-10592 Entity denotes S209
T7006 10599-10603 Protein denotes IKKβ
T7007 10650-10656 Protein denotes kinase
T7008 10707-10711 Protein denotes RPS3
T7009 10778-10785 Negative_regulation denotes reduced
T7010 10786-10791 Protein denotes IKKβ–
T7011 10791-10799 Positive_regulation denotes mediated
T7012 10800-10804 Protein denotes RPS3
T7013 10805-10820 Phosphorylation denotes phosphorylation
T7014 10928-10942 Phosphorylation denotes phosphorylated
T7015 10943-10947 Protein denotes RPS3
T7016 10959-10963 Protein denotes RPS3
T7017 10964-10968 Entity denotes S209
T7018 11052-11066 Entity denotes sequence motif
T7019 11093-11103 Binding denotes recognized
T7020 11140-11144 Protein denotes IKKβ
T7021 11298-11302 Protein denotes RPS3
T7022 11303-11307 Entity denotes S209
T7023 11308-11323 Phosphorylation denotes phosphorylation
T7024 11328-11331 Positive_regulation denotes due
T7025 11368-11372 Protein denotes IKKβ
T7026 11416-11421 Binding denotes bound
T7027 11452-11456 Entity denotes S209
T7028 11487-11491 Protein denotes IKKβ
T7029 11492-11506 Phosphorylation denotes phosphorylates
T7030 11507-11511 Protein denotes RPS3
T7031 11574-11583 Protein denotes Flag-RPS3
T7032 11608-11612 Protein denotes IKKβ
T7033 11650-11664 Positive_regulation denotes overexpressing
T7034 11665-11669 Protein denotes IKKβ
T7035 11670-11678 Positive_regulation denotes enhanced
T7036 11679-11688 Protein denotes Flag-RPS3
T7037 11689-11704 Phosphorylation denotes phosphorylation
T7038 11710-11725 Phosphorylation denotes phosphorylation
T7039 11742-11752 Negative_regulation denotes eliminated
T7040 11793-11797 Entity denotes S209
T7041 11833-11837 Protein denotes IKKβ
T7042 11838-11853 Phosphorylation denotes phosphorylation
T7043 11885-11911 Protein denotes phospho-S209 RPS3 antibody
T7044 11942-11946 Protein denotes RPS3
T7045 11951-11965 Phosphorylation denotes phosphorylated
T7046 11969-11973 Entity denotes S209
T7047 11984-11993 Regulation denotes dependent
T7048 12043-12047 Protein denotes RPS3
T8864 12116-12131 Phosphorylation denotes Phosphorylation
T8865 12135-12139 Protein denotes RPS3
T8866 12188-12192 Entity denotes S209 true
T8867 12193-12208 Phosphorylation denotes phosphorylation
T8868 12217-12221 Regulation denotes role
T8869 12229-12236 Entity denotes nuclear
T8870 12237-12250 Localization denotes translocation
T8871 12254-12258 Protein denotes RPS3
T8872 12344-12348 Protein denotes RPS3
T8873 12349-12360 Gene_expression denotes transfected true
T8874 12583-12592 Positive_regulation denotes triggered
T8875 12603-12612 Protein denotes Flag-RPS3
T8876 12613-12620 Entity denotes nuclear true
T8877 12621-12634 Localization denotes translocation
T8878 12655-12659 Protein denotes RPS3
T8879 12668-12675 Entity denotes nuclear
T8880 12676-12689 Localization denotes translocation
T8881 12694-12704 Negative_regulation denotes attenuated
T8882 12765-12779 Positive_regulation denotes overexpressing
T8883 12780-12784 Protein denotes IKKβ
T8884 12788-12792 Protein denotes RPS3
T8885 12793-12800 Entity denotes nuclear
T8886 12801-12814 Localization denotes translocation
T8887 12816-12820 Protein denotes IKKβ true
T8888 12864-12874 Protein denotes luciferase
T8889 12915-12922 Positive_regulation denotes induced
T8890 12927-12934 Entity denotes nuclear
T8891 12935-12948 Localization denotes translocation
T8892 12978-12982 Protein denotes RPS3
T8893 13018-13022 Entity denotes S209
T8894 13023-13038 Phosphorylation denotes phosphorylation
T8895 13042-13050 Positive_regulation denotes critical
T8896 13076-13083 Positive_regulation denotes induced
T8897 13084-13088 Protein denotes RPS3
T8898 13089-13096 Entity denotes nuclear
T8899 13097-13110 Localization denotes translocation
T8900 13127-13131 Regulation denotes role
T8901 13135-13139 Entity denotes S209 true
T8902 13140-13155 Phosphorylation denotes phosphorylation
T8903 13159-13163 Protein denotes RPS3 true
T8904 13198-13206 Negative_regulation denotes silenced
T8905 13218-13222 Protein denotes RPS3
T8906 13223-13233 Gene_expression denotes expression true
T8907 13301-13305 Protein denotes RPS3
T8908 13378-13382 Protein denotes RPS3 true
T8909 13414-13424 Protein denotes RPS3 siRNA
T8910 13434-13441 Negative_regulation denotes reduced true
T8911 13453-13457 Protein denotes RPS3
T8912 13502-13508 Regulation denotes affect true
T8913 13520-13530 Gene_expression denotes expression
T8914 13534-13550 Protein denotes Flag-tagged RPS3
T8915 13580-13587 Negative_regulation denotes lacking true
T8916 13629-13633 Protein denotes RPS3
T8917 13634-13643 Negative_regulation denotes knockdown
T8918 13644-13651 Negative_regulation denotes reduced
T8919 13656-13663 Positive_regulation denotes induced
T8920 13664-13674 Gene_expression denotes expression
T8921 13687-13693 Positive_regulation denotes driven true
T8922 13694-13704 Protein denotes luciferase true
T8923 13731-13739 Negative_regulation denotes impaired true
T8924 13740-13750 Protein denotes luciferase
T8925 13758-13764 Positive_regulation denotes caused
T8926 13768-13772 Protein denotes RPS3
T8927 13773-13783 Negative_regulation denotes deficiency
T8928 13799-13807 Negative_regulation denotes restored
T8929 13852-13856 Protein denotes RPS3
T8930 13923-13930 Negative_regulation denotes failure
T8931 13948-13955 Positive_regulation denotes restore
T8932 14040-14054 Positive_regulation denotes overexpression
T8933 14058-14083 Protein denotes green fluorescent protein
T8934 14085-14088 Protein denotes GFP
T8935 14151-14155 Protein denotes RPS3
T8936 14220-14224 Protein denotes RPS3
T8937 14225-14229 Entity denotes S209
T8938 14230-14245 Phosphorylation denotes phosphorylation
T8939 14377-14381 Entity denotes S209
T8940 14382-14397 Phosphorylation denotes phosphorylation
T8941 14398-14405 Regulation denotes affects
T8942 14406-14410 Protein denotes RPS3
T8943 14415-14418 Protein denotes p65
T8944 14419-14430 Binding denotes recruitment
T8945 14500-14504 Protein denotes RPS3
T8946 14505-14514 Negative_regulation denotes knockdown
T8947 14543-14554 Binding denotes recruitment
T8948 14570-14579 Gene_expression denotes expressed
T8949 14618-14622 Protein denotes RPS3
T8950 14630-14638 Entity denotes κB sites
T8951 14646-14652 Protein denotes NFKBIA
T8952 14657-14660 Protein denotes IL8
T8953 14661-14670 Entity denotes promoters
T8954 14688-14698 Gene_expression denotes expressing
T8955 14699-14703 Protein denotes RPS3
T8956 14704-14709 Entity denotes S209A
T8957 14717-14723 Regulation denotes impact
T8958 14727-14730 Protein denotes p65
T8959 14731-14738 Entity denotes nuclear
T8960 14739-14752 Localization denotes translocation
T8961 14771-14781 Negative_regulation denotes attenuated
T8962 14782-14785 Protein denotes p65
T8963 14786-14797 Binding denotes recruitment
T8964 14846-14849 Protein denotes p65
T8965 14850-14860 Localization denotes attraction
T8966 14864-14868 Protein denotes RPS3
T8967 14917-14921 Protein denotes CD25
T8968 14926-14935 Positive_regulation denotes increased
T8969 15029-15038 Protein denotes Flag-RPS3
T8970 15042-15045 Protein denotes p65
T8971 15046-15057 Binding denotes recruitment
T8972 15061-15065 Protein denotes ACTB
T8973 15066-15074 Entity denotes promoter
T8974 15162-15173 Binding denotes recruitment
T8975 15177-15181 Protein denotes RPS3
T8976 15208-15219 Binding denotes recruitment
T8977 15223-15226 Protein denotes p65
T8978 15234-15243 Entity denotes promoters
T8979 15256-15260 Entity denotes S209
T8980 15262-15275 Protein denotes Interleukin 8
T8981 15277-15281 Protein denotes IL-8
T8982 15283-15292 Localization denotes secretion
T8983 15293-15300 Positive_regulation denotes induced
T8984 15366-15375 Negative_regulation denotes decreased
T8985 15396-15403 Negative_regulation denotes reduced
T8986 15404-15408 Protein denotes RPS3
T8987 15409-15412 Protein denotes p65
T8988 15413-15424 Binding denotes recruitment
T8989 15432-15435 Protein denotes IL8
T8990 15436-15444 Entity denotes κB sites
T8991 15464-15469 Entity denotes S209A
T8992 15499-15503 Protein denotes RPS3
T8993 15551-15555 Protein denotes CD25
T8994 15556-15566 Gene_expression denotes expression
T8995 15614-15618 Protein denotes RPS3
T8996 15673-15677 Protein denotes RPS3
T8997 15678-15682 Entity denotes S209
T8998 15683-15698 Phosphorylation denotes phosphorylation
T8999 15702-15706 Protein denotes IKKβ
T9000 15721-15729 Positive_regulation denotes required
T9001 15734-15738 Protein denotes RPS3
T11724 15797-15802 Protein denotes NleH1
T11725 15803-15811 Negative_regulation denotes inhibits
T11726 15812-15816 Protein denotes RPS3
T11727 15817-15832 Phosphorylation denotes phosphorylation
T11728 16148-16153 Protein denotes NleH1
T11729 16154-16159 Binding denotes binds
T11730 16167-16177 Negative_regulation denotes attenuates
T11731 16178-16182 Protein denotes RPS3
T11732 16183-16190 Entity denotes nuclear
T11733 16191-16204 Localization denotes translocation
T11734 16221-16225 Protein denotes RPS3
T11735 16285-16290 Protein denotes NleH1
T11736 16307-16317 Negative_regulation denotes inhibiting
T11737 16318-16322 Protein denotes RPS3
T11738 16323-16327 Entity denotes S209
T11739 16328-16343 Phosphorylation denotes phosphorylation
T11740 16393-16401 Protein denotes NleH1-HA
T11741 16418-16422 Protein denotes TNFα
T11742 16501-16506 Protein denotes NleH1
T11743 16507-16514 Negative_regulation denotes reduced
T11744 16520-16523 Protein denotes TNF true
T11745 16524-16531 Positive_regulation denotes induced
T11746 16550-16554 Protein denotes RPS3
T11747 16555-16570 Phosphorylation denotes phosphorylation
T11748 16616-16626 Gene_expression denotes Expressing
T11749 16627-16632 Protein denotes NleH1
T11750 16664-16667 Protein denotes TNF
T11751 16668-16675 Positive_regulation denotes induced
T11752 16680-16690 Positive_regulation denotes activation
T11753 16694-16698 Protein denotes IκBα true
T11754 16699-16710 Protein_catabolism denotes degradation true
T11755 16732-16736 Negative_regulation denotes lack
T11756 16740-16745 Protein denotes NleH1
T11757 16746-16752 Regulation denotes impact
T11758 16756-16759 Protein denotes p65
T11759 16760-16767 Entity denotes nuclear
T11760 16768-16782 Localization denotes translocation9
T11761 16810-16815 Protein denotes NleH1
T11762 16816-16824 Negative_regulation denotes inhibits
T11763 16825-16829 Protein denotes RPS3
T11764 16830-16845 Phosphorylation denotes phosphorylation
T11765 16913-16920 Negative_regulation denotes lacking
T11766 16928-16933 Protein denotes nleH1
T11767 16935-16941 Protein denotes ΔnleH1
T11768 17003-17008 Protein denotes NleH1
T11769 17031-17036 Protein denotes ΔescN
T11770 17060-17063 Protein denotes TNF
T11771 17095-17103 Positive_regulation denotes increase
T11772 17107-17111 Protein denotes RPS3
T11773 17112-17116 Entity denotes S209
T11774 17117-17132 Phosphorylation denotes phosphorylation
T11775 17180-17184 Protein denotes RPS3
T11776 17185-17189 Entity denotes S209
T11777 17190-17205 Phosphorylation denotes phosphorylation
T11778 17224-17232 Negative_regulation denotes impaired
T11779 17302-17305 Protein denotes TNF
T11780 17306-17313 Positive_regulation denotes induced
T11781 17314-17318 Protein denotes RPS3
T11782 17319-17323 Entity denotes S209
T11783 17324-17339 Phosphorylation denotes phosphorylation
T11784 17344-17354 Negative_regulation denotes unimpaired
T11785 17385-17391 Protein denotes ΔnleH1
T11786 17395-17400 Protein denotes ΔescN
T11787 17457-17463 Protein denotes ΔnleH1
T11788 17467-17472 Protein denotes ΔescN
T11789 17503-17513 Negative_regulation denotes attenuated
T11790 17514-17517 Protein denotes TNF
T11791 17518-17525 Positive_regulation denotes induced
T11792 17526-17530 Protein denotes RPS3
T11793 17531-17538 Entity denotes nuclear
T11794 17539-17553 Localization denotes translocation9
T11795 17576-17580 Protein denotes RPS3
T11796 17581-17596 Phosphorylation denotes phosphorylation
T11797 17605-17612 Entity denotes nuclear
T11798 17613-17626 Localization denotes translocation
T11799 17728-17732 Protein denotes RPS3
T11800 17733-17737 Entity denotes S209
T11801 17738-17753 Phosphorylation denotes phosphorylation
T13717 19409-19415 Protein denotes ΔnleH1
T13718 19424-19431 Phosphorylation denotes phospho
T13719 19432-19436 Protein denotes RPS3
T13720 19437-19447 Gene_expression denotes expression
T13721 19510-19515 Protein denotes NleH1
T13722 19516-19524 Negative_regulation denotes inhibits
T13723 19525-19529 Protein denotes RPS3
T13724 19530-19534 Entity denotes S209
T13725 19535-19550 Phosphorylation denotes phosphorylation
T14525 19647-19652 Protein denotes NleH1
T14526 19664-19668 Protein denotes IKKβ
T14527 19693-19698 Protein denotes NleH1
T14528 19770-19780 Entity denotes lysine 159
T14529 19824-19829 Protein denotes NleH1
T14530 19830-19838 Negative_regulation denotes inhibits
T14531 19839-19843 Protein denotes RPS3 true
T14532 19844-19848 Entity denotes S209
T14533 19849-19864 Phosphorylation denotes phosphorylation
T14534 19934-19943 Protein denotes His-NleH1
T14535 19965-19974 Protein denotes His-NleH1
T14536 20008-20013 Protein denotes NleH1
T14537 20017-20035 Phosphorylation denotes autophosphorylated
T14538 20056-20061 Protein denotes NleH1
T14539 20062-20073 Negative_regulation denotes kinase-dead
T14540 20134-20142 Positive_regulation denotes required
T14541 20147-20152 Protein denotes NleH1
T14542 20156-20163 Negative_regulation denotes inhibit
T14543 20164-20168 Protein denotes IKKβ
T14544 20169-20184 Phosphorylation denotes phosphorlyation
T14545 20188-20192 Protein denotes RPS3
T14546 20196-20200 Entity denotes S209
T14547 20217-20227 Gene_expression denotes expressing
T14548 20254-20259 Protein denotes NleH1
T14549 20285-20290 Protein denotes NleH1
T14550 20291-20301 Gene_expression denotes expression
T14551 20316-20323 Negative_regulation denotes reduced
T14552 20328-20335 Positive_regulation denotes induced
T14553 20336-20340 Protein denotes RPS3
T14554 20341-20345 Entity denotes S209
T14555 20346-20361 Phosphorylation denotes phosphorylation
T14556 20420-20425 Protein denotes NleH1
T14557 20445-20453 Positive_regulation denotes required
T14558 20457-20464 Negative_regulation denotes protect
T14559 20465-20469 Protein denotes RPS3
T14560 20475-20479 Protein denotes IKKβ
T14561 20480-20488 Positive_regulation denotes mediated true
T14562 20489-20504 Phosphorylation denotes phosphorylation
T14563 20648-20652 Protein denotes NleH
T14564 20653-20662 Negative_regulation denotes inhibited
T14565 20663-20667 Protein denotes RPS3
T14566 20668-20675 Entity denotes nuclear true
T14567 20676-20689 Localization denotes translocation
T14568 20694-20698 Protein denotes RPS3
T14569 20699-20708 Regulation denotes dependent
T14570 20715-20725 Protein denotes luciferase
T14571 20770-20775 Protein denotes NleH1
T14572 20797-20801 Protein denotes RPS3
T14573 20802-20806 Entity denotes S209
T14574 20807-20822 Phosphorylation denotes phosphorylation
T14575 20918-20928 Positive_regulation denotes stimulated
T14576 20941-20949 Positive_regulation denotes increase
T14577 20953-20957 Protein denotes RPS3
T14578 20958-20962 Entity denotes S209
T14579 20963-20978 Phosphorylation denotes phosphorylation
T14580 20995-21007 Positive_regulation denotes augmentation
T14581 21011-21015 Protein denotes RPS3 true
T14582 21016-21031 Phosphorylation denotes phosphorylation
T14583 21036-21043 Negative_regulation denotes reduced
T14584 21113-21117 Protein denotes RPS3
T14585 21118-21133 Phosphorylation denotes phosphorylation
T14586 21138-21146 Positive_regulation denotes enhanced
T14587 21199-21206 Negative_regulation denotes lacking
T14588 21207-21211 Protein denotes NleH
T14589 21222-21227 Protein denotes ΔnleH
T14590 21262-21267 Protein denotes NleH1 true
T14591 21307-21312 Protein denotes ΔnleH
T14592 21348-21355 Gene_expression denotes express
T14593 21390-21395 Protein denotes NleH1
T14594 21411-21416 Protein denotes ΔnleH
T14595 21439-21444 Protein denotes NleH1
T14596 21452-21461 Negative_regulation denotes abolished true
T14597 21462-21465 Protein denotes TNF
T14598 21466-21473 Positive_regulation denotes induced
T14599 21474-21478 Protein denotes RPS3
T14600 21479-21483 Entity denotes S209 true
T14601 21484-21499 Phosphorylation denotes phosphorylation
T14602 21543-21550 Negative_regulation denotes inhibit true
T14603 21551-21555 Protein denotes RPS3
T14604 21556-21571 Phosphorylation denotes phosphorylation
T14605 21628-21633 Protein denotes NleH1
T14606 21653-21661 Positive_regulation denotes required true
T14607 21665-21670 Negative_regulation denotes block
T14608 21671-21675 Protein denotes RPS3 true
T14609 21676-21680 Entity denotes S209
T14610 21681-21696 Phosphorylation denotes phosphorylation true
T14611 21750-21755 Protein denotes NleH1
T14612 21782-21788 Negative_regulation denotes impair true
T14613 21800-21807 Entity denotes nuclear
T14614 21808-21821 Localization denotes translocation
T14615 21825-21829 Protein denotes RPS3
T14616 21830-21837 Positive_regulation denotes trigged
T14617 21845-21866 Positive_regulation denotes constitutively-active
T14618 21867-21871 Protein denotes IKKβ
T14619 21873-21877 Protein denotes IKKβ
T14620 21923-21933 Gene_expression denotes expressing
T14621 21954-21963 Protein denotes SSEE IKKβ
T14622 21974-21983 Positive_regulation denotes triggered
T14623 21989-21993 Protein denotes RPS3
T14624 21994-22001 Entity denotes nuclear
T14625 22002-22015 Localization denotes translocation
T14626 22025-22036 Negative_regulation denotes kinase-dead
T14627 22037-22041 Protein denotes IKKβ
T14628 22043-22047 Negative_regulation denotes SSAA
T14629 22068-22072 Protein denotes RPS3
T14630 22073-22080 Entity denotes nuclear
T14631 22081-22093 Localization denotes accumulation
T14632 22112-22120 Negative_regulation denotes retarded
T14633 22217-22223 Protein denotes ΔnleH1
T14634 22227-22232 Protein denotes ΔescN
T14635 22255-22263 Negative_regulation denotes impaired
T14636 22264-22268 Protein denotes RPS3
T14637 22269-22276 Entity denotes nuclear
T14638 22277-22290 Localization denotes translocation
T14639 22301-22305 Protein denotes IKKβ
T14640 22310-22314 Protein denotes IKKβ
T14641 22316-22320 Negative_regulation denotes SSEE
T14642 22322-22332 Gene_expression denotes expressing
T14643 22390-22396 Regulation denotes affect
T14644 22401-22405 Protein denotes RPS3
T14645 22406-22413 Entity denotes nuclear
T14646 22414-22427 Localization denotes translocation
T14647 22431-22435 Protein denotes IKKβ
T14648 22437-22441 Negative_regulation denotes SSAA
T14649 22443-22453 Gene_expression denotes expressing
T14650 22525-22530 Protein denotes NleH1
T14651 22557-22564 Negative_regulation denotes inhibit
T14652 22565-22569 Protein denotes RPS3
T14653 22570-22577 Entity denotes nuclear
T14654 22578-22591 Localization denotes translocation
T14655 22606-22616 Gene_expression denotes expressing
T14656 22617-22632 Positive_regulation denotes constitutively-
T14657 22632-22641 Positive_regulation denotes activated
T14658 22642-22646 Protein denotes IKKβ
T14659 22668-22673 Protein denotes NleH1
T14660 22689-22702 Phosphorylation denotes phosphorylate
T14661 22703-22707 Protein denotes IKKβ
T14662 22713-22723 Negative_regulation denotes inhibiting
T14663 22724-22728 Protein denotes IKKβ
T14664 22729-22737 Positive_regulation denotes mediated
T14665 22738-22742 Protein denotes RPS3
T14666 22743-22747 Entity denotes S209
T14667 22748-22763 Phosphorylation denotes phosphorylation
T14668 22826-22842 Protein denotes Flag-IKKβ (K44A)
T14669 22872-22881 Protein denotes His-NleH1
T14670 22901-22905 Protein denotes IKKβ
T14671 22906-22925 Phosphorylation denotes autophosphorylation
T14672 22944-22949 Protein denotes NleH1
T14673 22950-22957 Positive_regulation denotes induced
T14674 22958-22973 Phosphorylation denotes phosphorylation
T14675 23039-23043 Protein denotes IKKβ
T14676 23138-23143 Protein denotes NleH1
T14677 23150-23155 Regulation denotes alter
T14678 23160-23164 Protein denotes IKKβ
T14679 23277-23281 Protein denotes IKKβ
T14680 23296-23300 Protein denotes IKKβ
T14681 23301-23315 Phosphorylation denotes phosphorylated
T14682 23316-23320 Protein denotes RPS3
T14683 23343-23351 Protein denotes GST-IκBα
T14684 23469-23473 Protein denotes IKKβ
T14685 23479-23484 Protein denotes NleH1
T14686 23485-23492 Negative_regulation denotes reduced
T14687 23493-23497 Protein denotes IKKβ
T14688 23498-23506 Positive_regulation denotes mediated
T14689 23507-23511 Protein denotes RPS3
T14690 23512-23527 Phosphorylation denotes phosphorylation
T14691 23570-23574 Protein denotes IKKβ
T14692 23575-23583 Positive_regulation denotes mediated
T14693 23584-23592 Protein denotes GST-IκBα
T14694 23593-23608 Phosphorylation denotes phosphorylation
T14695 23685-23690 Protein denotes NleH1
T14696 23691-23699 Positive_regulation denotes mediated
T14697 23700-23715 Phosphorylation denotes phosphorylation
T14698 23719-23738 Phosphorylation denotes autophosphorylation
T14699 23742-23746 Protein denotes RPS3
T14700 23750-23758 Protein denotes GST-IκBα
T14701 23786-23791 Protein denotes NleH1
T14702 23832-23836 Protein denotes IKKβ
T14703 23842-23852 Negative_regulation denotes inhibiting
T14704 23857-23861 Protein denotes IKKβ
T14705 23862-23870 Positive_regulation denotes mediated
T14706 23871-23875 Protein denotes RPS3
T14707 23876-23880 Entity denotes S209
T14708 23881-23896 Phosphorylation denotes phosphorylation
T17951 24005-24009 Protein denotes RPS3 true
T17952 24174-24182 Positive_regulation denotes triggers
T17953 24183-24187 Protein denotes RPS3
T17954 24191-24202 Localization denotes translocate
T17955 24273-24277 Protein denotes IKKβ
T17956 24278-24286 Positive_regulation denotes mediated
T17957 24287-24291 Protein denotes RPS3
T17958 24292-24296 Entity denotes S209 true
T17959 24297-24312 Phosphorylation denotes phosphorylation
T17960 24364-24371 Entity denotes nuclear
T17961 24372-24378 Localization denotes import
T17962 24449-24453 Protein denotes IKKβ
T17963 24586-24590 Protein denotes RPS3
T17964 24716-24720 Protein denotes IKKβ
T17965 24815-24819 Protein denotes IKKβ
T17966 24829-24833 Protein denotes IKKα
T17967 24835-24849 Phosphorylation denotes phosphorylated true
T17968 24850-24854 Protein denotes RPS3
T17969 24900-24910 Regulation denotes modulation
T17970 24915-24919 Protein denotes RPS3
T17971 24920-24927 Entity denotes nuclear
T17972 24928-24941 Localization denotes translocation
T17973 24943-24946 Positive_regulation denotes via
T17974 24963-24973 Binding denotes engagement
T17975 25035-25048 Phosphorylation denotes phosphorylate
T17976 25049-25052 Protein denotes p65
T17977 25060-25064 Binding denotes bind true
T17978 25072-25085 Phosphorylation denotes phosphorylate
T17979 25086-25090 Protein denotes IKKβ
T17980 25144-25148 Protein denotes IKKβ
T17981 25149-25154 Binding denotes bound
T17982 25165-25172 Regulation denotes account true
T17983 25190-25194 Protein denotes RPS3
T17984 25195-25210 Phosphorylation denotes phosphorylation
T17985 25246-25250 Protein denotes IKKβ
T17986 25308-25312 Protein denotes RPS3
T17987 25534-25538 Protein denotes RPS3
T17988 25687-25691 Protein denotes IKKβ
T17989 25692-25700 Positive_regulation denotes mediated
T17990 25701-25705 Protein denotes RPS3
T17991 25706-25710 Entity denotes S209
T17992 25711-25726 Phosphorylation denotes phosphorylation
T17993 25831-25836 Protein denotes NleH1
T17994 25850-25855 Binding denotes binds
T17995 25859-25863 Protein denotes RPS3
T17996 25997-26002 Protein denotes NleH1
T17997 26015-26023 Negative_regulation denotes inhibits
T17998 26024-26028 Protein denotes RPS3
T17999 26029-26044 Phosphorylation denotes phosphorylation
T18000 26065-26072 Entity denotes nuclear
T18001 26073-26086 Localization denotes translocation
T18002 26167-26172 Protein denotes NleH1
T18003 26190-26203 Phosphorylation denotes phosphorylate
T18004 26204-26208 Protein denotes IKKβ
T18005 26234-26242 Positive_regulation denotes required
T18006 26246-26253 Negative_regulation denotes inhibit
T18007 26254-26258 Protein denotes IKKβ
T18008 26259-26267 Positive_regulation denotes mediated
T18009 26268-26272 Protein denotes RPS3
T18010 26273-26277 Entity denotes S209
T18011 26278-26293 Phosphorylation denotes phosphorylation
T18012 26424-26429 Protein denotes NleH1
T18013 26468-26472 Protein denotes IKKβ
T18014 26739-26744 Protein denotes NleH1
T18015 26777-26781 Protein denotes RPS3
T18016 26911-26914 Protein denotes IL8
T18017 26937-26942 Protein denotes NleH1
T18018 26952-26957 Negative_regulation denotes block
T18019 26964-26967 Protein denotes p65
T18020 26968-26975 Entity denotes nuclear
T18021 26976-26989 Localization denotes translocation
T18022 27019-27022 Protein denotes p65
T18023 27023-27032 Regulation denotes dependent
T18024 27037-27041 Protein denotes RPS3
T18025 27175-27185 Negative_regulation denotes inhibiting
T18026 27186-27190 Protein denotes RPS3
T18027 27229-27234 Protein denotes NleH1
T18028 27830-27834 Protein denotes RPS3
T18029 27853-27856 Protein denotes p65
T18030 27857-27864 Entity denotes nuclear
T18031 27865-27878 Localization denotes translocation
T18032 28136-28140 Protein denotes RPS3
T20199 29180-29194 Phosphorylation denotes phosphorylated
T20493 29321-29338 Protein denotes Flag-IKKβ (SSEE),
T20494 29339-29356 Protein denotes Flag-IKKβ (SSAA),
T20495 29361-29375 Protein denotes HA-IκBα (SSAA)
T20496 29481-29488 Protein denotes HA-IκBα
T20497 29493-29509 Protein denotes IKKβ (K44A)-Flag
T20498 29558-29567 Protein denotes Flag-RPS3
T20499 29569-29577 Protein denotes GST-RPS3
T20500 29579-29586 Protein denotes HA-RPS3
T20501 29588-29593 Protein denotes VN-HA
T20502 29595-29603 Protein denotes NleH1-HA
T20503 29665-29669 Protein denotes RPS3
T20980 30276-30277 Negative_regulation denotes -
T20981 30296-30300 Protein denotes IKKβ
T20982 30305-30309 Protein denotes IKKα
T20983 30470-30478 Protein denotes GST-RPS3
T20984 30483-30487 Protein denotes RPS3
T21359 31009-31017 Protein denotes GST-RPS3
T21360 31049-31053 Protein denotes IKKβ
T21540 31486-31490 Protein denotes IKKα
T21541 31526-31530 Protein denotes IKKβ
T21542 31566-31570 Protein denotes IκBα
T21543 31606-31610 Protein denotes RPS3
T22032 32705-32715 Protein denotes luciferase
T22033 32742-32752 Protein denotes luciferase
T22208 33114-33117 Protein denotes IL8
T22209 33122-33128 Protein denotes NFKBIA
T22210 33141-33145 Protein denotes ACTB
T22538 34908-34915 Protein denotes albumin
T23097 35151-35155 Protein denotes IL-8
T23098 35242-35255 Protein denotes Interleukin-8
T23099 35275-35278 Protein denotes kit
T11802 17757-17766 Positive_regulation denotes important
T11803 17771-17778 Entity denotes nuclear
T11804 17779-17792 Localization denotes translocation
T11805 17813-17818 Protein denotes NleH1
T11806 17819-17827 Negative_regulation denotes inhibits
T11807 17828-17832 Protein denotes RPS3
T11808 17833-17837 Entity denotes S209
T11809 17838-17853 Phosphorylation denotes phosphorylation
T11810 17891-17895 Protein denotes RPS3
T11811 17944-17947 Protein denotes IL8
T11812 17949-17955 Protein denotes NFKBIA
T11813 17961-17968 Protein denotes TNFAIP3
T11814 18128-18134 Protein denotes ΔnleH1
T11815 18138-18143 Protein denotes ΔescN
T11816 18176-18184 Negative_regulation denotes deleting
T11817 18185-18190 Protein denotes nleH1
T11818 18198-18204 Regulation denotes impact
T11819 18212-18222 Gene_expression denotes expression
T11820 18260-18264 Protein denotes CD25
T11821 18269-18277 Protein denotes TNFSF13B
T11822 18343-18348 Protein denotes NleH1
T11823 18414-18422 Negative_regulation denotes blocking
T11824 18423-18427 Protein denotes RPS3
T11825 18428-18432 Entity denotes S209
T11826 18433-18448 Phosphorylation denotes phosphorylation
T11827 18480-18484 Protein denotes RPS3
T13700 18516-18521 Protein denotes NleH1
T13701 18522-18530 Negative_regulation denotes inhibits
T13702 18531-18535 Protein denotes RPS3
T13703 18536-18540 Entity denotes S209
T13704 18541-18556 Phosphorylation denotes phosphorylation true
T13705 18665-18671 Protein denotes ΔnleH1
T13706 18771-18777 Protein denotes ΔnleH1
T13707 19007-19012 Protein denotes NleH1
T13708 19013-19020 Negative_regulation denotes blocked
T13709 19021-19025 Protein denotes RPS3
T13710 19026-19030 Entity denotes S209
T13711 19031-19046 Phosphorylation denotes phosphorylation
T13712 19064-19074 Negative_regulation denotes preventing
T13713 19075-19079 Protein denotes RPS3
T13714 19080-19087 Entity denotes nuclear
T13715 19088-19101 Localization denotes translocation
T13716 19361-19365 Protein denotes RPS3
R28 T33 T34 themeOf IKKβ,phosphorylation
R29 T34 T35 causeOf phosphorylation,regulates
R30 T36 T38 themeOf RPS3,translocation
R31 T37 T38 locationOf nuclear,translocation
R32 T38 T35 themeOf translocation,regulates
R33 T40 T39 equivalentTo RPS3,ribosomal protein S3
R34 T41 T43 themeOf RPS3,translocation
R35 T42 T43 locationOf nuclear,translocation
R36 T43 T44 themeOf translocation,regulated
R37 T46 T48 causeOf phosphorylation,crucial
R38 T47 T46 themeOf serine 209,phosphorylation
R39 T47 T45 partOf serine 209,IKKβ
R40 T49 T51 themeOf RPS3,localization
R41 T50 T51 locationOf nuclear,localization
R42 T51 T52 themeOf localization,in response to
R43 T51 T48 themeOf localization,crucial
R44 T52 T48 themeOf in response to,crucial
R45 T53 T54 causeOf NleH1,inhibited
R46 T54 T58 causeOf inhibited,blocked
R47 T56 T55 partOf S209,RPS3
R48 T56 T57 themeOf S209,phosphorylation
R49 T57 T54 themeOf phosphorylation,inhibited
R50 T59 T58 themeOf RPS3,blocked
R561 T677 T676 equivalentTo p65,RelA
R562 T683 T682 equivalentTo RPS3,ribosomal protein S3
R563 T687 T688 themeOf immunoglobulin κ light chain,expression
R564 T689 T690 causeOf NleH1,attenuating
R565 T689 T694 causeOf NleH1,affecting
R566 T691 T693 themeOf RPS3,translocation
R567 T692 T693 locationOf nuclear,translocation
R568 T693 T690 themeOf translocation,attenuating
R569 T695 T696 themeOf p65,localization9
R570 T696 T694 themeOf localization9,affecting
R571 T698 T700 themeOf RPS3,translocation
R572 T699 T700 locationOf nuclear,translocation
R573 T700 T697 themeOf translocation,induce
R574 T702 T703 themeOf RPS3,participates
R575 T702 T701 themeOf RPS3,binding
R576 T704 T705 themeOf RPS3,phosphorylated
R577 T706 T707 themeOf RPS3,phosphorylated
R578 T709 T711 causeOf Inhibitor of κB (IκB) kinase beta,phosphorylated
R579 T710 T709 equivalentTo IKKβ,Inhibitor of κB (IκB) kinase beta
R580 T713 T712 partOf serine 209,RPS3
R581 T713 T711 themeOf serine 209,phosphorylated
R582 T714 T718 themeOf RPS3,association
R583 T715 T716 themeOf S209,phosphorylation
R584 T715 T714 partOf S209,RPS3
R585 T716 T717 causeOf phosphorylation,enhanced
R586 T718 T717 themeOf association,enhanced
R587 T720 T721 themeOf RPS3,entry
R588 T720 T723 themeOf RPS3,translocation
R589 T721 T719 themeOf entry,mediating
R590 T722 T723 locationOf nuclear,translocation
R591 T723 T719 themeOf translocation,mediating
R592 T724 T725 causeOf coli NleH1,inhibited
R593 T727 T726 partOf S209,RPS3
R1558 T1962 T1963 themeOf RPS3,phosphorylation
R1559 T1964 T1965 themeOf RPS3,phosphorylated
R1560 T1966 T1967 themeOf RPS3,phosphorylated
R1561 T1970 T1969 themeOf RPS3,increase
R1562 T1972 T1971 partOf residues,RPS3
R1563 T1972 T1973 themeOf residues,phosphorylated
R1564 T1976 T1975 themeOf phosphorylation,stimulated
R1565 T1977 T1976 themeOf IκBα,phosphorylation
R1566 T1978 T1979 themeOf RPS3,phosphorylation
R1567 T1982 T1981 themeOf RPS3,phosphorylation
R2023 T2568 T2570 themeOf RPS3,interaction
R2024 T2569 T2570 themeOf IKKβ,interaction
R2025 T2580 T2579 themeOf IKKβ,activated
R2026 T2580 T2581 themeOf IKKβ,bind
R2027 T2583 T2582 themeOf RPS3,phosphorylate
R2028 T2583 T2581 themeOf RPS3,bind
R2029 T2585 T2584 themeOf IKKβ,expressed
R2030 T2585 T2587 themeOf IKKβ,interacted
R2031 T2586 T2587 themeOf RPS3,interacted
R2032 T2586 T2584 themeOf RPS3,expressed
R2033 T2588 T2590 themeOf IKKβ,interaction
R2034 T2589 T2590 themeOf RPS3,interaction
R2035 T2591 T2593 themeOf RPS3,association
R2036 T2592 T2593 themeOf IKKβ,association
R2037 T2593 T2594 themeOf association,augmented
R2038 T2596 T2597 themeOf serine,phosphorylation
R2039 T2596 T2595 partOf serine,RPS3
R2040 T2599 T2598 themeOf RPS3,interaction
R2041 T2600 T2598 themeOf IKKα,interaction
R2625 T3354 T3355 causeOf IKKβ,required
R2626 T3356 T3358 themeOf RPS3,translocation
R2627 T3357 T3358 locationOf nuclear,translocation
R2628 T3358 T3355 themeOf translocation,required
R2629 T3359 T3361 themeOf RPS3,interaction
R2630 T3360 T3361 themeOf IKKβ,interaction
R2631 T3361 T3362 causeOf interaction,required
R2632 T3363 T3365 themeOf RPS3,translocation
R2633 T3364 T3365 locationOf nuclear,translocation
R2634 T3365 T3362 themeOf translocation,required
R2635 T3367 T3369 themeOf IKKα,expression
R2636 T3368 T3369 themeOf IKKβ,expression
R2637 T3369 T3366 themeOf expression,knocked down
R2638 T3371 T3373 themeOf RPS3,migration
R2639 T3372 T3373 locationOf nuclear,migration
R2640 T3373 T3370 themeOf migration,induced
R2641 T3375 T3377 themeOf RPS3,translocation
R2642 T3376 T3377 locationOf nuclear,translocation
R2643 T3377 T3374 themeOf translocation,triggered
R2644 T3378 T3380 themeOf RPS3,translocation
R2645 T3379 T3380 locationOf nuclear,translocation
R2646 T3380 T3381 themeOf translocation,impaired
R2647 T3382 T3383 themeOf IKKα,silencing
R2648 T3383 T3381 causeOf silencing,impaired
R2649 T3385 T3384 themeOf IKKβ,knockdown
R2650 T3385 T3386 causeOf IKKβ,attenuated
R2651 T3387 T3389 themeOf RPS3,accumulation
R2652 T3388 T3389 locationOf nuclear,accumulation
R2653 T3389 T3386 themeOf accumulation,attenuated
R2654 T3389 T3390 themeOf accumulation,following
R2655 T3391 T3394 causeOf expression,necessary
R2656 T3392 T3391 themeOf IKKβ,expression
R2657 T3393 T3391 themeOf IKKα,expression
R2658 T3395 T3394 themeOf induced,necessary
R2659 T3396 T3398 themeOf RPS3,translocation
R2660 T3397 T3398 locationOf nuclear,translocation
R2661 T3398 T3395 themeOf translocation,induced
R2662 T3399 T3401 themeOf p65,translocation
R2663 T3400 T3401 locationOf nuclear,translocation
R2664 T3401 T3402 themeOf translocation,blocked
R2665 T3403 T3404 locationOf nuclear,translocation
R2666 T3405 T3404 themeOf RPS3,translocation
R2667 T3406 T3407 themeOf expressing,kinase-dead
R2668 T3409 T3406 themeOf IKKβ,expressing
R2669 T3409 T3407 themeOf IKKβ,kinase-dead
R2670 T3409 T3408 themeOf IKKβ,constitutively-active
R2671 T3410 T3411 causeOf IKKβ,induced
R2672 T3412 T3411 themeOf dependent,induced
R2673 T3416 T3417 themeOf IKKβ,SSAA
R2674 T3416 T3418 themeOf IKKβ,expressing
R2675 T3419 T3420 themeOf RPS3,translocated
R2676 T3421 T3420 locationOf nucleus,translocated
R2677 T3424 T3425 themeOf RPS3,increased
R2678 T3426 T3427 themeOf IKKβ,expressing
R2679 T3428 T3430 themeOf IKKβ,expressing
R2680 T3428 T3429 themeOf IKKβ,SSAA
R2681 T3431 T3432 causeOf IKKβ,necessary
R2682 T3431 T3433 causeOf IKKβ,sufficient
R2683 T3434 T3436 themeOf RPS3,translocation
R2684 T3435 T3436 locationOf nuclear,translocation
R2685 T3436 T3433 themeOf translocation,sufficient
R2686 T3436 T3437 themeOf translocation,in response to
R2687 T3437 T3433 themeOf in response to,sufficient
R3921 T4913 T4914 themeOf IκBα,degradation
R3922 T4915 T4917 themeOf RPS3,translocation
R3923 T4916 T4917 locationOf nuclear,translocation
R3924 T4919 T4920 locationOf nuclear,import
R3925 T4920 T4918 themeOf import,regulates
R3926 T4921 T4920 themeOf Rel,import
R3927 T4922 T4926 themeOf RPS3,translocation
R3928 T4923 T4926 locationOf nuclear,translocation
R3929 T4923 T4924 locationOf nuclear,localization
R3930 T4925 T4926 locationOf nuclear,translocation
R3931 T4927 T4928 themeOf p65,translocation6
R3932 T4930 T4931 themeOf RPS3,association
R3933 T4931 T4932 themeOf association,enhanced
R3934 T4933 T4937 themeOf RPS3,translocation
R3935 T4933 T4934 themeOf RPS3,binding
R3936 T4934 T4935 causeOf binding,essential
R3937 T4936 T4937 locationOf nuclear,translocation
R3938 T4937 T4935 themeOf translocation,essential
R3939 T4938 T4939 themeOf IκBα,degradation
R3940 T4939 T4940 causeOf degradation,prerequisite
R3941 T4941 T4940 themeOf unmask,prerequisite
R3942 T4942 T4943 partOf NLS,p65
R3943 T4942 T4941 themeOf NLS,unmask
R3944 T4942 T4944 partOf NLS,RPS3
R3945 T4944 T4946 themeOf RPS3,bind
R3946 T4945 T4946 themeOf IκBα,bind
R3947 T4947 T4946 themeOf p65,bind
R3948 T4948 T4949 themeOf IκBα,degradation
R3949 T4949 T4950 causeOf degradation,required
R3950 T4953 T4952 themeOf RPS3,association
R3951 T4955 T4954 themeOf IκBα,overexpressing
R3952 T4956 T4957 themeOf IκBα,SSAA
R3953 T4956 T4961 themeOf IκBα,degradation
R3954 T4956 T4960 themeOf IκBα,phosphorylation
R3955 T4958 T4959 causeOf IKKβ,induced
R3956 T4960 T4959 themeOf phosphorylation,induced
R3957 T4961 T4959 themeOf degradation,induced
R3958 T4963 T4962 themeOf IκBα,transfected
R3959 T4965 T4964 themeOf interaction,augmented
R3960 T4966 T4965 themeOf RPS3,interaction
R3961 T4967 T4968 themeOf RPS3,association
R3962 T4968 T4969 themeOf association,abolished
R3963 T4970 T4969 causeOf degradable,abolished
R3964 T4971 T4970 themeOf IκBα,degradable
R3965 T4971 T4969 causeOf IκBα,abolished
R3966 T4973 T4975 themeOf RPS3,translocation
R3967 T4974 T4975 locationOf nuclear,translocation
R3968 T4976 T4977 themeOf RPS3,association
R3969 T4979 T4977 themeOf RPS3,association
R3970 T4981 T4982 themeOf IκBα,expression
R3971 T4982 T4980 themeOf expression,reducing
R3972 T4983 T4985 causeOf siRNA,depleted
R3973 T4986 T4985 themeOf IκBα,depleted
R3974 T4987 T4988 themeOf RPS3,association
R3975 T4988 T4989 themeOf association,augmented
R3976 T4990 T4991 themeOf RPS3,detected
R3977 T4993 T4994 themeOf IκBα,degradation
R3978 T4994 T4992 themeOf degradation,induce
R3979 T4996 T4995 themeOf association,increased
R3980 T4997 T4996 themeOf RPS3,association
R3981 T4998 T4999 locationOf nuclear,accumulation
R3982 T5000 T4999 themeOf RPS3,accumulation
R3983 T5001 T5002 themeOf IκBα,degradation
R3984 T5004 T5003 themeOf association,promotes
R3985 T5005 T5003 themeOf transport,promotes
R3986 T5006 T5005 themeOf RPS3,transport
R3987 T5007 T5008 themeOf IκBα,degradation
R3988 T5011 T5012 themeOf RPS3,association
R3989 T5012 T5010 themeOf association,required
R3990 T5013 T5014 themeOf IκBα,phosphorylation
R3991 T5013 T5015 themeOf IκBα,degradation
R3992 T5014 T5017 causeOf phosphorylation,cause
R3993 T5015 T5017 causeOf degradation,cause
R3994 T5015 T5016 causeOf degradation,required
R3995 T5018 T5019 themeOf RPS3,association
R3996 T5018 T5022 themeOf RPS3,translocation
R3997 T5019 T5017 themeOf association,cause
R3998 T5019 T5020 causeOf association,followed
R3999 T5021 T5022 locationOf nuclear,translocation
R4000 T5022 T5020 themeOf translocation,followed
R4001 T5024 T5026 themeOf phosphorylation,required
R4002 T5025 T5024 themeOf RPS3,phosphorylation
R5542 T6969 T6970 causeOf IKKβ,phosphorylates
R5543 T6972 T6973 themeOf IKKβ,phosphorylates
R5544 T6974 T6973 themeOf 14-3-3β,phosphorylates
R5545 T6975 T6973 themeOf Bcl10,phosphorylates
R5546 T6979 T6978 themeOf RPS3,phosphorylate
R5547 T6982 T6981 themeOf IKKα,autophosphorylatd
R5548 T6983 T6981 themeOf IKKβ,autophosphorylatd
R5549 T6985 T6984 themeOf GST-IκBα,phosporylated
R5550 T6989 T6990 themeOf GST-RPS3,phosphorylated
R5551 T6991 T6990 causeOf IKKβ,phosphorylated
R5552 T6994 T6993 partOf amino acid residue(s,RPS3
R5553 T6996 T6995 causeOf IKKβ,phosphorylated
R5554 T6998 T6997 themeOf RPS3,phosphorylated
R5555 T6999 T7000 causeOf IKKβ,phosphorylated
R5556 T7001 T7000 themeOf S209,phosphorylated
R5557 T7010 T7011 causeOf IKKβ–,mediated
R5558 T7011 T7009 themeOf mediated,reduced
R5559 T7012 T7013 themeOf RPS3,phosphorylation
R5560 T7013 T7011 themeOf phosphorylation,mediated
R5561 T7015 T7014 themeOf RPS3,phosphorylated
R5562 T7016 T7019 themeOf RPS3,recognized
R5563 T7017 T7019 themeOf S209,recognized
R5564 T7017 T7016 partOf S209,RPS3
R5565 T7018 T7016 partOf sequence motif,RPS3
R5566 T7018 T7019 themeOf sequence motif,recognized
R5567 T7022 T7023 themeOf S209,phosphorylation
R5568 T7022 T7021 partOf S209,RPS3
R5569 T7023 T7024 themeOf phosphorylation,due
R5570 T7025 T7024 causeOf IKKβ,due
R5571 T7026 T7024 causeOf bound,due
R5572 T7027 T7030 partOf S209,RPS3
R5573 T7028 T7029 causeOf IKKβ,phosphorylates
R5574 T7030 T7029 themeOf RPS3,phosphorylates
R5575 T7033 T7035 causeOf overexpressing,enhanced
R5576 T7034 T7035 causeOf IKKβ,enhanced
R5577 T7034 T7033 themeOf IKKβ,overexpressing
R5578 T7036 T7037 themeOf Flag-RPS3,phosphorylation
R5579 T7037 T7035 themeOf phosphorylation,enhanced
R5580 T7037 T7039 themeOf phosphorylation,eliminated
R5581 T7038 T7039 themeOf phosphorylation,eliminated
R5582 T7040 T7039 causeOf S209,eliminated
R5583 T7040 T7042 themeOf S209,phosphorylation
R5584 T7040 T7036 partOf S209,Flag-RPS3
R5585 T7045 T7047 themeOf phosphorylated,dependent
R5586 T7046 T7045 themeOf S209,phosphorylated
R5587 T7046 T7044 partOf S209,RPS3
R7069 T8865 T8864 themeOf RPS3,Phosphorylation
R7070 T8866 T8871 partOf S209,RPS3
R7071 T8866 T8867 themeOf S209,phosphorylation
R7072 T8867 T8868 causeOf phosphorylation,role
R7073 T8869 T8870 locationOf nuclear,translocation
R7074 T8870 T8868 themeOf translocation,role
R7075 T8871 T8870 themeOf RPS3,translocation
R7076 T8872 T8873 themeOf RPS3,transfected
R7077 T8875 T8877 themeOf Flag-RPS3,translocation
R7078 T8876 T8877 locationOf nuclear,translocation
R7079 T8877 T8874 themeOf translocation,triggered
R7080 T8878 T8880 themeOf RPS3,translocation
R7081 T8879 T8880 locationOf nuclear,translocation
R7082 T8880 T8881 themeOf translocation,attenuated
R7083 T8883 T8882 themeOf IKKβ,overexpressing
R7084 T8884 T8886 themeOf RPS3,translocation
R7085 T8885 T8886 locationOf nuclear,translocation
R7086 T8890 T8891 locationOf nuclear,translocation
R7087 T8891 T8889 themeOf translocation,induced
R7088 T8892 T8891 themeOf RPS3,translocation
R7089 T8893 T8897 partOf S209,RPS3
R7090 T8893 T8894 themeOf S209,phosphorylation
R7091 T8894 T8895 causeOf phosphorylation,critical
R7092 T8896 T8895 themeOf induced,critical
R7093 T8897 T8899 themeOf RPS3,translocation
R7094 T8898 T8899 locationOf nuclear,translocation
R7095 T8899 T8896 themeOf translocation,induced
R7096 T8901 T8902 themeOf S209,phosphorylation
R7097 T8901 T8903 partOf S209,RPS3
R7098 T8903 T8902 themeOf RPS3,phosphorylation
R7099 T8905 T8906 themeOf RPS3,expression
R7100 T8906 T8904 themeOf expression,silenced
R7101 T8909 T8910 causeOf RPS3 siRNA,reduced
R7102 T8909 T8912 causeOf RPS3 siRNA,affect
R7103 T8911 T8910 themeOf RPS3,reduced
R7104 T8913 T8912 themeOf expression,affect
R7105 T8914 T8913 themeOf Flag-tagged RPS3,expression
R7106 T8916 T8917 themeOf RPS3,knockdown
R7107 T8917 T8918 causeOf knockdown,reduced
R7108 T8919 T8918 themeOf induced,reduced
R7109 T8920 T8919 themeOf expression,induced
R7110 T8922 T8920 themeOf luciferase,expression
R7111 T8922 T8921 themeOf luciferase,driven
R7112 T8923 T8928 themeOf impaired,restored
R7113 T8924 T8923 themeOf luciferase,impaired
R7114 T8926 T8927 themeOf RPS3,deficiency
R7115 T8927 T8923 causeOf deficiency,impaired
R7116 T8927 T8925 causeOf deficiency,caused
R7117 T8927 T8928 themeOf deficiency,restored
R7118 T8929 T8928 causeOf RPS3,restored
R7119 T8933 T8932 themeOf green fluorescent protein,overexpression
R7120 T8934 T8933 equivalentTo GFP,green fluorescent protein
R7121 T8937 T8936 partOf S209,RPS3
R7122 T8937 T8938 themeOf S209,phosphorylation
R7123 T8939 T8943 partOf S209,p65
R7124 T8939 T8942 partOf S209,RPS3
R7125 T8939 T8940 themeOf S209,phosphorylation
R7126 T8940 T8941 causeOf phosphorylation,affects
R7127 T8942 T8944 themeOf RPS3,recruitment
R7128 T8943 T8944 themeOf p65,recruitment
R7129 T8944 T8941 themeOf recruitment,affects
R7130 T8945 T8946 themeOf RPS3,knockdown
R7131 T8950 T8952 partOf κB sites,IL8
R7132 T8950 T8948 themeOf κB sites,expressed
R7133 T8950 T8947 themeOf κB sites,recruitment
R7134 T8950 T8951 partOf κB sites,NFKBIA
R7135 T8956 T8957 causeOf S209A,impact
R7136 T8956 T8954 themeOf S209A,expressing
R7137 T8956 T8961 causeOf S209A,attenuated
R7138 T8956 T8955 partOf S209A,RPS3
R7139 T8958 T8960 themeOf p65,translocation
R7140 T8959 T8960 locationOf nuclear,translocation
R7141 T8960 T8957 themeOf translocation,impact
R7142 T8962 T8963 themeOf p65,recruitment
R7143 T8963 T8961 themeOf recruitment,attenuated
R7144 T8964 T8965 themeOf p65,attraction
R7145 T8965 T8968 themeOf attraction,increased
R7146 T8969 T8971 themeOf Flag-RPS3,recruitment
R7147 T8970 T8971 themeOf p65,recruitment
R7148 T8973 T8971 locationOf promoter,recruitment
R7149 T8975 T8974 themeOf RPS3,recruitment
R7150 T8977 T8976 themeOf p65,recruitment
R7151 T8978 T8974 locationOf promoters,recruitment
R7152 T8978 T8976 locationOf promoters,recruitment
R7153 T8979 T8975 partOf S209,RPS3
R7154 T8980 T8982 themeOf Interleukin 8,secretion
R7155 T8981 T8980 equivalentTo IL-8,Interleukin 8
R7156 T8982 T8983 themeOf secretion,induced
R7157 T8982 T8984 themeOf secretion,decreased
R7158 T8983 T8984 themeOf induced,decreased
R7159 T8985 T8984 causeOf reduced,decreased
R7160 T8986 T8988 themeOf RPS3,recruitment
R7161 T8987 T8988 themeOf p65,recruitment
R7162 T8988 T8985 themeOf recruitment,reduced
R7163 T8990 T8989 partOf κB sites,IL8
R7164 T8990 T8988 themeOf κB sites,recruitment
R7165 T8991 T8985 causeOf S209A,reduced
R7166 T8991 T8992 partOf S209A,RPS3
R7167 T8993 T8994 themeOf CD25,expression
R7168 T8997 T8998 themeOf S209,phosphorylation
R7169 T8997 T8996 partOf S209,RPS3
R7170 T8999 T8998 causeOf IKKβ,phosphorylation
R7171 T9001 T9000 themeOf RPS3,required
R9428 T11724 T11725 causeOf NleH1,inhibits
R9429 T11726 T11727 themeOf RPS3,phosphorylation
R9430 T11727 T11725 themeOf phosphorylation,inhibits
R9431 T11728 T11729 themeOf NleH1,binds
R9432 T11729 T11730 causeOf binds,attenuates
R9433 T11731 T11733 themeOf RPS3,translocation
R9434 T11732 T11733 locationOf nuclear,translocation
R9435 T11733 T11730 themeOf translocation,attenuates
R9436 T11735 T11736 causeOf NleH1,inhibiting
R9437 T11738 T11737 partOf S209,RPS3
R9438 T11738 T11739 themeOf S209,phosphorylation
R9439 T11739 T11736 themeOf phosphorylation,inhibiting
R9440 T11742 T11743 causeOf NleH1,reduced
R9441 T11744 T11745 causeOf TNF,induced
R9442 T11745 T11743 themeOf induced,reduced
R9443 T11746 T11747 themeOf RPS3,phosphorylation
R9444 T11747 T11745 themeOf phosphorylation,induced
R9445 T11747 T11743 themeOf phosphorylation,reduced
R9446 T11749 T11748 themeOf NleH1,Expressing
R9447 T11750 T11751 causeOf TNF,induced
R9448 T11752 T11751 themeOf activation,induced
R9449 T11753 T11754 themeOf IκBα,degradation
R9450 T11754 T11751 themeOf degradation,induced
R9451 T11756 T11755 themeOf NleH1,lack
R9452 T11758 T11760 themeOf p65,translocation9
R9453 T11759 T11760 locationOf nuclear,translocation9
R9454 T11760 T11757 themeOf translocation9,impact
R9455 T11761 T11762 causeOf NleH1,inhibits
R9456 T11763 T11764 themeOf RPS3,phosphorylation
R9457 T11764 T11762 themeOf phosphorylation,inhibits
R9458 T11766 T11765 themeOf nleH1,lacking
R9459 T11770 T11771 causeOf TNF,increase
R9460 T11773 T11772 partOf S209,RPS3
R9461 T11773 T11774 themeOf S209,phosphorylation
R9462 T11774 T11771 themeOf phosphorylation,increase
R9463 T11776 T11775 partOf S209,RPS3
R9464 T11776 T11777 themeOf S209,phosphorylation
R9465 T11777 T11778 themeOf phosphorylation,impaired
R9466 T11779 T11780 causeOf TNF,induced
R9467 T11780 T11784 themeOf induced,unimpaired
R9468 T11782 T11783 themeOf S209,phosphorylation
R9469 T11782 T11781 partOf S209,RPS3
R9470 T11783 T11784 themeOf phosphorylation,unimpaired
R9471 T11783 T11780 themeOf phosphorylation,induced
R9472 T11785 T11784 causeOf ΔnleH1,unimpaired
R9473 T11786 T11784 causeOf ΔescN,unimpaired
R9474 T11787 T11789 causeOf ΔnleH1,attenuated
R9475 T11788 T11789 causeOf ΔescN,attenuated
R9476 T11790 T11791 causeOf TNF,induced
R9477 T11791 T11789 themeOf induced,attenuated
R9478 T11792 T11794 themeOf RPS3,translocation9
R9479 T11793 T11794 locationOf nuclear,translocation9
R9480 T11794 T11791 themeOf translocation9,induced
R9481 T11795 T11796 themeOf RPS3,phosphorylation
R9482 T11795 T11798 themeOf RPS3,translocation
R9483 T11797 T11798 locationOf nuclear,translocation
R9484 T11799 T11804 themeOf RPS3,translocation
R9485 T11800 T11799 partOf S209,RPS3
R9486 T11800 T11801 themeOf S209,phosphorylation
R9487 T11801 T11802 causeOf phosphorylation,important
R9488 T11803 T11804 locationOf nuclear,translocation
R9489 T11804 T11802 themeOf translocation,important
R9490 T11805 T11806 causeOf NleH1,inhibits
R9491 T11808 T11807 partOf S209,RPS3
R9492 T11808 T11809 themeOf S209,phosphorylation
R9493 T11809 T11806 themeOf phosphorylation,inhibits
R9494 T11811 T11813 themeOf IL8,TNFAIP3
R9495 T11812 T11813 themeOf NFKBIA,TNFAIP3
R9496 T11817 T11816 themeOf nleH1,deleting
R9497 T11817 T11818 causeOf nleH1,impact
R9498 T11819 T11818 themeOf expression,impact
R9499 T11822 T11823 causeOf NleH1,blocking
R9500 T11825 T11824 partOf S209,RPS3
R9502 T11826 T11823 themeOf phosphorylation,blocking
R11659 T14528 T14527 partOf lysine 159,NleH1
R11660 T14529 T14530 causeOf NleH1,inhibits
R11661 T14532 T14533 themeOf S209,phosphorylation
R11662 T14532 T14531 partOf S209,RPS3
R11663 T14533 T14530 themeOf phosphorylation,inhibits
R11664 T14536 T14539 themeOf NleH1,kinase-dead
R11665 T14536 T14537 themeOf NleH1,autophosphorylated
R11666 T14538 T14539 themeOf NleH1,kinase-dead
R11667 T14542 T14540 themeOf inhibit,required
R11668 T14544 T14542 themeOf phosphorlyation,inhibit
R11669 T14546 T14545 partOf S209,RPS3
R11670 T14546 T14544 themeOf S209,phosphorlyation
R11671 T14548 T14547 themeOf NleH1,expressing
R11672 T14549 T14550 themeOf NleH1,expression
R11673 T14550 T14551 causeOf expression,reduced
R11674 T14552 T14551 themeOf induced,reduced
R11675 T14554 T14555 themeOf S209,phosphorylation
R11676 T14554 T14553 partOf S209,RPS3
R11677 T14555 T14552 themeOf phosphorylation,induced
R11678 T14558 T14557 themeOf protect,required
R11679 T14559 T14562 themeOf RPS3,phosphorylation
R11680 T14560 T14561 causeOf IKKβ,mediated
R11681 T14561 T14558 themeOf mediated,protect
R11682 T14562 T14561 themeOf phosphorylation,mediated
R11683 T14563 T14564 causeOf NleH,inhibited
R11684 T14565 T14567 themeOf RPS3,translocation
R11685 T14566 T14567 locationOf nuclear,translocation
R11686 T14567 T14564 themeOf translocation,inhibited
R11687 T14568 T14569 causeOf RPS3,dependent
R11688 T14569 T14564 themeOf dependent,inhibited
R11689 T14573 T14574 themeOf S209,phosphorylation
R11690 T14573 T14572 partOf S209,RPS3
R11691 T14578 T14577 partOf S209,RPS3
R11692 T14578 T14579 themeOf S209,phosphorylation
R11693 T14579 T14576 themeOf phosphorylation,increase
R11694 T14580 T14583 themeOf augmentation,reduced
R11695 T14581 T14582 themeOf RPS3,phosphorylation
R11696 T14582 T14583 themeOf phosphorylation,reduced
R11697 T14582 T14580 themeOf phosphorylation,augmentation
R11698 T14584 T14585 themeOf RPS3,phosphorylation
R11699 T14585 T14586 themeOf phosphorylation,enhanced
R11700 T14587 T14586 causeOf lacking,enhanced
R11701 T14588 T14587 themeOf NleH,lacking
R11702 T14590 T14592 themeOf NleH1,express
R11703 T14591 T14592 themeOf ΔnleH,express
R11704 T14593 T14592 themeOf NleH1,express
R11705 T14595 T14596 causeOf NleH1,abolished
R11706 T14597 T14598 causeOf TNF,induced
R11707 T14598 T14596 themeOf induced,abolished
R11708 T14600 T14601 themeOf S209,phosphorylation
R11709 T14600 T14599 partOf S209,RPS3
R11710 T14601 T14598 themeOf phosphorylation,induced
R11711 T14603 T14604 themeOf RPS3,phosphorylation
R11712 T14604 T14602 themeOf phosphorylation,inhibit
R11713 T14607 T14606 themeOf block,required
R11714 T14609 T14608 partOf S209,RPS3
R11715 T14609 T14610 themeOf S209,phosphorylation
R11716 T14610 T14607 themeOf phosphorylation,block
R11717 T14613 T14614 locationOf nuclear,translocation
R11718 T14614 T14612 themeOf translocation,impair
R11719 T14614 T14616 themeOf translocation,trigged
R11720 T14615 T14614 themeOf RPS3,translocation
R11721 T14618 T14616 causeOf IKKβ,trigged
R11722 T14618 T14617 themeOf IKKβ,constitutively-active
R11723 T14619 T14616 causeOf IKKβ,trigged
R11724 T14619 T14617 themeOf IKKβ,constitutively-active
R11725 T14620 T14622 causeOf expressing,triggered
R11726 T14621 T14620 themeOf SSEE IKKβ,expressing
R11727 T14623 T14625 themeOf RPS3,translocation
R11728 T14624 T14625 locationOf nuclear,translocation
R11729 T14625 T14622 themeOf translocation,triggered
R11730 T14627 T14626 themeOf IKKβ,kinase-dead
R11731 T14627 T14628 themeOf IKKβ,SSAA
R11732 T14629 T14631 themeOf RPS3,accumulation
R11733 T14630 T14631 locationOf nuclear,accumulation
R11734 T14631 T14632 themeOf accumulation,retarded
R11735 T14633 T14635 causeOf ΔnleH1,impaired
R11736 T14634 T14635 causeOf ΔescN,impaired
R11737 T14636 T14638 themeOf RPS3,translocation
R11738 T14637 T14638 locationOf nuclear,translocation
R11739 T14638 T14635 themeOf translocation,impaired
R11740 T14639 T14641 themeOf IKKβ,SSEE
R11741 T14640 T14641 themeOf IKKβ,SSEE
R11742 T14640 T14642 themeOf IKKβ,expressing
R11743 T14644 T14646 themeOf RPS3,translocation
R11744 T14645 T14646 locationOf nuclear,translocation
R11745 T14646 T14643 themeOf translocation,affect
R11746 T14647 T14649 themeOf IKKβ,expressing
R11747 T14647 T14648 themeOf IKKβ,SSAA
R11748 T14650 T14651 causeOf NleH1,inhibit
R11749 T14652 T14654 themeOf RPS3,translocation
R11750 T14653 T14654 locationOf nuclear,translocation
R11751 T14654 T14651 themeOf translocation,inhibit
R11752 T14658 T14655 themeOf IKKβ,expressing
R11753 T14658 T14657 themeOf IKKβ,activated
R11754 T14659 T14662 causeOf NleH1,inhibiting
R11755 T14661 T14660 themeOf IKKβ,phosphorylate
R11756 T14663 T14664 causeOf IKKβ,mediated
R11757 T14664 T14662 themeOf mediated,inhibiting
R11758 T14666 T14665 partOf S209,RPS3
R11759 T14666 T14667 themeOf S209,phosphorylation
R11760 T14667 T14664 themeOf phosphorylation,mediated
R11761 T14670 T14671 themeOf IKKβ,autophosphorylation
R11762 T14672 T14673 causeOf NleH1,induced
R11763 T14674 T14673 themeOf phosphorylation,induced
R11764 T14676 T14677 causeOf NleH1,alter
R11765 T14680 T14681 causeOf IKKβ,phosphorylated
R11766 T14682 T14681 themeOf RPS3,phosphorylated
R11767 T14687 T14688 causeOf IKKβ,mediated
R11768 T14688 T14686 themeOf mediated,reduced
R11769 T14689 T14690 themeOf RPS3,phosphorylation
R11770 T14690 T14688 themeOf phosphorylation,mediated
R11771 T14691 T14692 causeOf IKKβ,mediated
R11772 T14693 T14694 themeOf GST-IκBα,phosphorylation
R11773 T14694 T14692 themeOf phosphorylation,mediated
R11774 T14695 T14696 causeOf NleH1,mediated
R11775 T14697 T14696 themeOf phosphorylation,mediated
R11776 T14698 T14696 themeOf autophosphorylation,mediated
R11777 T14699 T14698 themeOf RPS3,autophosphorylation
R11778 T14699 T14697 themeOf RPS3,phosphorylation
R11779 T14700 T14697 themeOf GST-IκBα,phosphorylation
R11780 T14700 T14698 themeOf GST-IκBα,autophosphorylation
R11781 T14701 T14703 causeOf NleH1,inhibiting
R11782 T14704 T14705 causeOf IKKβ,mediated
R11783 T14705 T14703 themeOf mediated,inhibiting
R11784 T14707 T14708 themeOf S209,phosphorylation
R11785 T14707 T14706 partOf S209,RPS3
R11786 T14708 T14705 themeOf phosphorylation,mediated
R14294 T17953 T17954 themeOf RPS3,translocate
R14295 T17954 T17952 themeOf translocate,triggers
R14296 T17955 T17956 causeOf IKKβ,mediated
R14297 T17957 T17961 themeOf RPS3,import
R14298 T17958 T17957 partOf S209,RPS3
R14299 T17958 T17959 themeOf S209,phosphorylation
R14300 T17959 T17956 themeOf phosphorylation,mediated
R14301 T17960 T17961 locationOf nuclear,import
R14302 T17965 T17967 causeOf IKKβ,phosphorylated
R14303 T17966 T17967 causeOf IKKα,phosphorylated
R14304 T17968 T17967 themeOf RPS3,phosphorylated
R14305 T17970 T17972 themeOf RPS3,translocation
R14306 T17971 T17972 locationOf nuclear,translocation
R14307 T17972 T17973 themeOf translocation,via
R14308 T17972 T17969 themeOf translocation,modulation
R14309 T17974 T17969 causeOf engagement,modulation
R14310 T17976 T17975 themeOf p65,phosphorylate
R14311 T17976 T17977 themeOf p65,bind
R14312 T17979 T17977 themeOf IKKβ,bind
R14313 T17979 T17978 themeOf IKKβ,phosphorylate
R14314 T17980 T17982 causeOf IKKβ,account
R14315 T17980 T17981 themeOf IKKβ,bound
R14316 T17981 T17982 causeOf bound,account
R14317 T17983 T17984 themeOf RPS3,phosphorylation
R14318 T17984 T17982 themeOf phosphorylation,account
R14319 T17988 T17989 causeOf IKKβ,mediated
R14320 T17991 T17990 partOf S209,RPS3
R14321 T17991 T17992 themeOf S209,phosphorylation
R14322 T17992 T17989 themeOf phosphorylation,mediated
R14323 T17993 T17994 themeOf NleH1,binds
R14324 T17995 T17994 themeOf RPS3,binds
R14325 T17996 T17997 causeOf NleH1,inhibits
R14326 T17998 T18001 themeOf RPS3,translocation
R14327 T17998 T17999 themeOf RPS3,phosphorylation
R14328 T17999 T17997 themeOf phosphorylation,inhibits
R14329 T18000 T18001 locationOf nuclear,translocation
R14330 T18004 T18003 themeOf IKKβ,phosphorylate
R14331 T18007 T18008 causeOf IKKβ,mediated
R14332 T18008 T18006 themeOf mediated,inhibit
R14333 T18010 T18009 partOf S209,RPS3
R14334 T18010 T18011 themeOf S209,phosphorylation
R14335 T18011 T18008 themeOf phosphorylation,mediated
R14336 T18017 T18018 causeOf NleH1,block
R14337 T18019 T18021 themeOf p65,translocation
R14338 T18020 T18021 locationOf nuclear,translocation
R14339 T18021 T18018 themeOf translocation,block
R14340 T18026 T18025 themeOf RPS3,inhibiting
R14341 T18027 T18025 causeOf NleH1,inhibiting
R14342 T18029 T18031 themeOf p65,translocation
R14343 T18030 T18031 locationOf nuclear,translocation
R9501 T11825 T11826 themeOf S209,phosphorylation
R10995 T13700 T13701 causeOf NleH1,inhibits
R10996 T13703 T13704 themeOf S209,phosphorylation
R10997 T13703 T13702 partOf S209,RPS3
R10998 T13704 T13701 themeOf phosphorylation,inhibits
R10999 T13707 T13708 causeOf NleH1,blocked
R11000 T13708 T13712 causeOf blocked,preventing
R11001 T13710 T13709 partOf S209,RPS3
R11002 T13710 T13711 themeOf S209,phosphorylation
R11003 T13711 T13708 themeOf phosphorylation,blocked
R11004 T13713 T13715 themeOf RPS3,translocation
R11005 T13714 T13715 locationOf nuclear,translocation
R11006 T13715 T13712 themeOf translocation,preventing
R11007 T13721 T13722 causeOf NleH1,inhibits
R11008 T13724 T13725 themeOf S209,phosphorylation
R11009 T13724 T13723 partOf S209,RPS3
R11010 T13725 T13722 themeOf phosphorylation,inhibits