PMC:3023298 / 76067-76699 JSONTXT

{"project":"2_test","denotations":[{"id":"21258649-10550301-103648921","span":{"begin":304,"end":307},"obj":"10550301"},{"id":"21258649-10550301-103648921","span":{"begin":304,"end":307},"obj":"10550301"},{"id":"21258649-9585365-103648922","span":{"begin":308,"end":311},"obj":"9585365"},{"id":"21258649-9585365-103648922","span":{"begin":308,"end":311},"obj":"9585365"},{"id":"21258649-10550301-83670108","span":{"begin":304,"end":307},"obj":"10550301"},{"id":"21258649-10550301-83670108","span":{"begin":304,"end":307},"obj":"10550301"},{"id":"21258649-9585365-83670109","span":{"begin":308,"end":311},"obj":"9585365"},{"id":"21258649-9585365-83670109","span":{"begin":308,"end":311},"obj":"9585365"},{"id":"T45684","span":{"begin":304,"end":307},"obj":"10550301"},{"id":"T72028","span":{"begin":304,"end":307},"obj":"10550301"},{"id":"T46302","span":{"begin":308,"end":311},"obj":"9585365"},{"id":"T40572","span":{"begin":308,"end":311},"obj":"9585365"}],"text":"Neuronal cell degeneration in AD occurs over a lengthy period. When considering the pathological classification of the primary neurodegeneration in AD it appears safe to conclude that based on morphology it is not classical apoptosis or necrosis. Autophagy could have a role in this neuronal cell death [249,261]. It might be more useful to consider neurofibrillary cell death separate from classical apoptosis and necrosis with some overlap in mechanisms according to the cell death matrix (Figure 2 and Figure 3). It could be important to know how neurons with neurofibrillary degeneration escape classical apoptosis and necrosis."}