PMC:3023298 / 66848-67623
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3023298","sourcedb":"PMC","sourceid":"3023298","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3023298","text":"Rigid conceptualization of cellular pathology is not realistic and is misleading and can hinder the goal of identification of relevant molecular mechanisms of neurodegeneration in complex biological systems, such as the developing, ageing or injured CNS, and ultimately limit the realization of therapeutic opportunities. For example, motor neuron degeneration in amyotrophic lateral sclerosis (ALS) was not considered to be a variant of apoptosis until the concept of the cell death continuum was applied [224], and now anti-apoptosis therapies are in clinical trials for the treatment of ALS [225]. The concept of the cell death continuum (Figure 2) might also be applicable to cytopathology in general, when dealing with cells that are resistant to one form of cell death.","tracks":[{"project":"2_test","denotations":[{"id":"21258649-10331434-83670062","span":{"begin":507,"end":510},"obj":"10331434"},{"id":"21258649-10331434-83670062","span":{"begin":507,"end":510},"obj":"10331434"},{"id":"21258649-19966906-83670063","span":{"begin":595,"end":598},"obj":"19966906"},{"id":"21258649-19966906-83670063","span":{"begin":595,"end":598},"obj":"19966906"},{"id":"T52794","span":{"begin":507,"end":510},"obj":"10331434"},{"id":"T44675","span":{"begin":507,"end":510},"obj":"10331434"},{"id":"T5870","span":{"begin":595,"end":598},"obj":"19966906"},{"id":"T82118","span":{"begin":595,"end":598},"obj":"19966906"},{"id":"T2744","span":{"begin":507,"end":510},"obj":"10331434"},{"id":"T60493","span":{"begin":507,"end":510},"obj":"10331434"},{"id":"T67126","span":{"begin":595,"end":598},"obj":"19966906"},{"id":"T58734","span":{"begin":595,"end":598},"obj":"19966906"}],"attributes":[{"subj":"21258649-10331434-83670062","pred":"source","obj":"2_test"},{"subj":"21258649-10331434-83670062","pred":"source","obj":"2_test"},{"subj":"21258649-19966906-83670063","pred":"source","obj":"2_test"},{"subj":"21258649-19966906-83670063","pred":"source","obj":"2_test"},{"subj":"T52794","pred":"source","obj":"2_test"},{"subj":"T44675","pred":"source","obj":"2_test"},{"subj":"T5870","pred":"source","obj":"2_test"},{"subj":"T82118","pred":"source","obj":"2_test"},{"subj":"T2744","pred":"source","obj":"2_test"},{"subj":"T60493","pred":"source","obj":"2_test"},{"subj":"T67126","pred":"source","obj":"2_test"},{"subj":"T58734","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93a8ec","default":true}]}]}}