PMC:3023298 / 111932-112816 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3023298","sourcedb":"PMC","sourceid":"3023298","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3023298","text":"Motor neurons in spinal cord degenerate in people with ALS. A, B. In normal individuals, the spinal cord contains many large, multipolar motor neurons (dark cells). C, D. In ALS, the anterior horn is depleted of large neurons (dark cells) and remaining neurons are atrophic. E-G. Nissl staining shows motor neurons that appear normal (E), attritional (F), and residual (G). H. ALS motor neurons accumulate DNA double-strand breaks in the nucleus (brown labeling). I. p53 (brown labeling) accumulates in the nucleus of motor neurons. J. ALS motor neurons are immunopositive for cleaved caspase-3 (black-dark green labeling), and discrete mitochondria (brown-orange labeling, detected with antibody to cytochrome c oxidase subunit I) accumulate around the nucleus (pale circle). Scale bars: A, 500 μm (same for C); B, 76 μm (same for D); E, 6 μm (same for F,G); H, 12 μm (same for I,J).","tracks":[]}