PMC:2952583 / 6808-9233 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2952583","sourcedb":"PMC","sourceid":"2952583","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2952583","text":"Diagnosis of Preeclampsia\nThe diagnosis of preeclampsia for each of these high-risk groups has been described previously [4]. In brief, preeclampsia was defined in normotensive women with normal urinary protein excretion at baseline as the development of hypertension plus one of the following: proteinuria, thrombocytopenia, or pulmonary edema. Hypertension was defined as a systolic and/or diastolic blood pressure equal to or greater than 140 mmHg and 90 mmHg respectively, on two occasions at least four hours apart and within the same period (antepartum, intrapartum, postpartum). Proteinuria was defined as excretion of ≥ 300mg of protein in a 24-hour urine collection, or two dipstick-test results of ≥ 2+ (100 mg per deciliter), the values recorded at least 4 hours apart, with no evidence of urinary tract infection. Thrombocytopenia was defined as a platelet count of less than 100,000 per cubic millimeter. In women who had normal blood pressure but proteinuria at baseline, the diagnosis of preeclampsia required thrombocytopenia, or a serum aspartate aminotransferase concentration of ≥ 70 U per liter, or hypertension and either severe headaches, epigastric pain, or worsening proteinuria (either five times the baseline value or twice baseline if the baseline value exceeded 5 g per 24 hours). In women who had hypertension but no proteinuria at baseline, a diagnosis of preeclampsia required the development of proteinuria or thrombocytopenia. A woman was deemed to have preeclampsia if she had an eclamptic convulsion or the HELLP syndrome, defined as hemolysis (serum total bilirubin concentration of ≥1.2 mg per deciliter (20 mmol per liter), a serum lactate dehydrogenase concentration of ≥ 600 U per liter, or hemolytic anemia as determined by the presence of schistocytes on a peripheral smear), elevated serum concentration of aspartate aminotransferase (≥ 70 U per liter), and thrombocytopenia. The records of all the women with apparent preeclampsia, worsening hypertension, new-onset proteinuria, or proteinuria at baseline (≥ 1+) were reviewed independently by three physicians who had to agree unanimously on the validity of the designated outcomes, a policy designed to ensure diagnostic consistency.\nThe clinical onset of preeclampsia was defined as the time at which a patient met the criteria for preeclampsia as described above rather than the time at which any single symptom first occurred.","divisions":[{"label":"title","span":{"begin":0,"end":25}},{"label":"p","span":{"begin":26,"end":2229}}],"tracks":[{"project":"2_test","denotations":[{"id":"20948996-9494145-87413004","span":{"begin":122,"end":123},"obj":"9494145"},{"id":"T46726","span":{"begin":122,"end":123},"obj":"9494145"}],"attributes":[{"subj":"20948996-9494145-87413004","pred":"source","obj":"2_test"},{"subj":"T46726","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#b3ec93","default":true}]}]}}