PMC:2952583 / 32670-34471
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2952583","sourcedb":"PMC","sourceid":"2952583","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2952583","text":"There has been considerable interest in the role and possible predictive value of the circulating angiogenic factors sFlt1, sEng and PlGF for preeclampsia as evidenced by a growing literature since 2003. Most studies have focused on low-risk populations while very few have evaluated the utility of these factors in high-risk pregnant populations, and the latter reports are limited in size or have evaluated subjects with different reasons for being classified high-risk together [7], [8], [9], [10], [11], [12]. In our study, maternal circulating sFlt1, sEng and PlGF were significantly higher at study entry in subjects with multifetal gestations compared with other high-risk groups, and PlGF was significantly lower in the diabetic subjects. The odds of developing preeclampsia were significantly increased for each 2-fold elevation in sFlt1, sEng and the angiogenic factor ratio, and were significantly decreased for each 2-fold elevation in PlGF at study entry in subjects with multifetal gestations. Similarly, the odds of developing preeclampsia are significantly decreased by half for each 2-fold elevation in maternal PlGF among diabetics, and increased by 60% for each 2-fold elevation in sEng and the angiogenic factor ratio at study entry for subjects with chronic hypertension and diabetes respectively. While these odds ratios are statistically significant, the confidence intervals associated with them are wide, and the magnitude of the elevation in the angiogenic factors in early pregnancy is large, which does not lend confidence to the possibility of these factors individually as useful predictors of preeclampsia in these high-risk groups. However, these data do not preclude the possible utility of these factors in a multiple marker screen for the prediction of preeclampsia.","tracks":[{"project":"2_test","denotations":[{"id":"20948996-16021077-87413006","span":{"begin":482,"end":483},"obj":"16021077"},{"id":"20948996-16580293-87413007","span":{"begin":487,"end":488},"obj":"16580293"},{"id":"20948996-16957146-87413008","span":{"begin":492,"end":493},"obj":"16957146"},{"id":"20948996-14764923-87413009","span":{"begin":497,"end":499},"obj":"14764923"},{"id":"20948996-18175241-87413010","span":{"begin":503,"end":505},"obj":"18175241"},{"id":"20948996-14764795-87413011","span":{"begin":509,"end":511},"obj":"14764795"},{"id":"T84379","span":{"begin":482,"end":483},"obj":"16021077"},{"id":"T96359","span":{"begin":487,"end":488},"obj":"16580293"},{"id":"T5387","span":{"begin":492,"end":493},"obj":"16957146"},{"id":"T22310","span":{"begin":497,"end":499},"obj":"14764923"},{"id":"T9476","span":{"begin":503,"end":505},"obj":"18175241"},{"id":"T68913","span":{"begin":509,"end":511},"obj":"14764795"}],"attributes":[{"subj":"20948996-16021077-87413006","pred":"source","obj":"2_test"},{"subj":"20948996-16580293-87413007","pred":"source","obj":"2_test"},{"subj":"20948996-16957146-87413008","pred":"source","obj":"2_test"},{"subj":"20948996-14764923-87413009","pred":"source","obj":"2_test"},{"subj":"20948996-18175241-87413010","pred":"source","obj":"2_test"},{"subj":"20948996-14764795-87413011","pred":"source","obj":"2_test"},{"subj":"T84379","pred":"source","obj":"2_test"},{"subj":"T96359","pred":"source","obj":"2_test"},{"subj":"T5387","pred":"source","obj":"2_test"},{"subj":"T22310","pred":"source","obj":"2_test"},{"subj":"T9476","pred":"source","obj":"2_test"},{"subj":"T68913","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93c6","default":true}]}]}}