PMC:2948432 / 22047-24899 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2948432","sourcedb":"PMC","sourceid":"2948432","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2948432","text":"TABLE 1 Median Gene Dosage by Probe Categories and Indicators of Relapse\nY = yes N = no Total numbers CDKN2B CDKN2B (Intron) CDKN2A p14ARF CDKN2A p16 Intron CDKN2A p16 All probes within CDKN2A MTAP Interferon 9p21.3\nRelapse Y 48 0.92 0.74 0.94 0.67 0.76 0.82 0.71 0.86 0.85\nN 27 0.88 0.78 0.98 0.77 0.84 0.91 0.77 0.90 0.90\nP-value (one-sided) 0.47 0.47 0.10 0.06 0.03 0.05 0.26 0.13 0.04\nUlceration Y 29 0.77 0.67 0.82 0.67 0.70 0.77 0.67 0.84 0.81\nN 46 0.96 0.78 0.98 0.73 0.82 0.91 0.77 0.90 0.92\nP-value (one-sided) 0.006 0.04 0.002 0.11 0.02 0.02 0.05 0.03 0.002\nBreslow thickness \u003c2 mm 18 1.04 0.86 0.97 0.75 0.84 0.91 0.8 0.89 0.92\n\u003e2\u003c4 mm 30 0.90 0.74 0.97 0.70 0.84 0.86 0.77 0.90 0.88\n\u003e4mm 27 0.79 0.67 0.84 0.70 0.76 0.77 0.67 0.83 0.81\nrs (P-value)* −0.31 (0.007) −0.14 (0.22) −0.29 (0.01) −0.06 (0.58) −0.28 (0.01) −0.24 (0.04) −0.19 (0.11) −0.11 (0.34) −0.27 (0.02)\nMitotic rate 0/ mm2 3 1.11 0.92 1.01 0.92 0.99 0.99 0.82 0.59 0.96\n1–6/ mm2 52 0.93 0.77 0.97 0.72 0.81 0.91 0.75 0.89 0.89\n\u003e6/ mm2 20 0.59 0.64 0.67 0.57 0.55 0.64 0.69 0.84 0.80\nP-value** 0.02 0.28 0.0006 0.28 0.004 0.005 0.37 0.12 0.02\nTumour site Head/neck/ hand/foot 15 1.06 0.74 1.00 0.85 0.80 0.84 0.69 0.88 0.88\nOther 60 0.90 0.76 0.93 0.69 0.78 0.85 0.76 0.88 0.87\nP-value (one-sided) 0.12 0.21 0.26 0.30 0.49 0.42 0.24 0.08 0.47\nMelanoma type (Wilcoxon two-sample tests were made between nodular and superficial spreading melanomas) Acral Lentiginous 2 0.44 0.37 0.76 0.53 0.61 0.62 0.44 0.67 0.58\nDesmoplastic 1 1.10 0.73 0.82 1.02 0.80 0.83 0.69 0.97 0.97\nIndeterminate 3 1.06 0.11 0.22 0.10 0.18 0.20 0.12 0.97 0.23\nNodular 28 0.88 0.78 0.93 0.72 0.77 0.81 0.67 0.88 0.83\nSuperficial- Spreading 41 0.96 0.77 0.96 0.70 0.82 0.91 0.77 0.87 0.90\nP-value (one-sided) 0.09 0.31 0.15 0.28 0.17 0.59 0.32 0.81 0.09\nBRAF mutation Y 25 0.93 0.75 0.93 0.65 0.82 0.85 0.77 0.87 0.89\nN 33 0.90 0.70 0.93 0.72 0.70 0.82 0.68 0.9 0.82\nP-value (one-sided) 0.13 0.45 0.36 0.44 0.06 0.16 0.04 0.49 0.13\nNRAS mutation Y 6 0.94 0.78 1.01 0.66 0.67 0.91 0.72 1.02 0.85\nN 45 0.94 0.75 0.95 0.75 0.79 0.85 0.71 0.87 0.88\nP-value (one-sided) 0.28 0.40 0.41 0.31 0.38 0.37 0.40 0.05 0.39\nBRAF or NRAS mutation Y 31 0.93 0.75 0.94 0.65 0.82 0.89 0.77 0.90 0.89\nN 19 0.90 0.73 0.93 0.73 0.73 0.82 0.68 0.84 0.83\nP-value (one-sided) 0.37 0.46 0.37 0.49 0.16 0.12 0.02 0.29 0.14\nThe statistical test used was the Wilcoxon two-sample test, unless otherwise stated (*Spearman correlation, **Kruskal-Wallis 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