PMC:2944667 / 44542-45238 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2944667","sourcedb":"PMC","sourceid":"2944667","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2944667","text":"Work in animal models reveals fundamental processes of brain development that are important to generate and test hypotheses concerning the pathogenesis of human mental disorders. This opens the possibility of manipulating stem cells in clinical populations. Avenues of research are utilizing general knowledge about stem cells to (1) use manipulated stem cells in a rehabilitative capacity in patients and (2) use stem cells from patients to understand pathophysiology and test candidate drugs for reversing abnormal cellular functions. We will review briefly here how knowledge about stem cell biology from both humans and animal models is being applied to develop these new research directions.","tracks":[]}