PMC:2944667 / 25225-25933
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2944667","sourcedb":"PMC","sourceid":"2944667","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2944667","text":"Although there is no clear mechanism accounting for the dysregulation in the trajectory of brain growth in ASD, one hypothesis stipulates that it is the consequence of altered regulation of neural stem cell proliferation or differentiation arising before birth (Vaccarino et al., 2009). Further evidence that early embryonic developmental events are implicated in the pathophysiology of autism comes from post mortem studies demonstrating a fundamental change in cortical structure. Patients with autism were shown to have an increased packing density of mini-columns, which are vertical (radial) assemblies of neurons thought to be anatomically and functionally interconnected (Casanova et al., 2003, 2006).","tracks":[{"project":"TEST0","denotations":[{"id":"20877431-232-240-637194","span":{"begin":280,"end":284},"obj":"[\"18850329\"]"},{"id":"20877431-213-221-637195","span":{"begin":696,"end":700},"obj":"[\"14678582\"]"},{"id":"20877431-219-227-637196","span":{"begin":702,"end":706},"obj":"[\"16819561\"]"}],"attributes":[{"subj":"20877431-232-240-637194","pred":"source","obj":"TEST0"},{"subj":"20877431-213-221-637195","pred":"source","obj":"TEST0"},{"subj":"20877431-219-227-637196","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"20877431-18850329-637194","span":{"begin":280,"end":284},"obj":"18850329"},{"id":"20877431-14678582-637195","span":{"begin":696,"end":700},"obj":"14678582"},{"id":"20877431-16819561-637196","span":{"begin":702,"end":706},"obj":"16819561"}],"attributes":[{"subj":"20877431-18850329-637194","pred":"source","obj":"0_colil"},{"subj":"20877431-14678582-637195","pred":"source","obj":"0_colil"},{"subj":"20877431-16819561-637196","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"20877431-18850329-38520471","span":{"begin":280,"end":284},"obj":"18850329"},{"id":"20877431-14678582-38520472","span":{"begin":696,"end":700},"obj":"14678582"},{"id":"20877431-16819561-38520473","span":{"begin":702,"end":706},"obj":"16819561"}],"attributes":[{"subj":"20877431-18850329-38520471","pred":"source","obj":"2_test"},{"subj":"20877431-14678582-38520472","pred":"source","obj":"2_test"},{"subj":"20877431-16819561-38520473","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93eceb","default":true},{"id":"0_colil","color":"#ecd193"},{"id":"2_test","color":"#b793ec"}]}]}}