PMC:2944667 / 2335-3351
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2944667","sourcedb":"PMC","sourceid":"2944667","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2944667","text":"Neural stem cells can be defined as self-renewing, multipotent cells that are present in both the embryonic and adult brain. Several recent research findings demonstrate that psychiatric illness may begin with abnormal specification, growth, expansion and differentiation of embryonic NSCs. For example, candidate susceptibility genes for schizophrenia, autism and major depression include those specifying the signaling molecule Disrupted In Schizophrenia-1 (DISC-1), the homeodomain gene engrailed-2 (EN-2), and several receptor tyrosine kinases (RTKs), including brain-derived neurotrophic factor (BDNF) and fibroblast growth factors (FGF), all of which have been shown to play important roles in NSCs or neuronal precursors. Hypotheses about how some of these factors relate to psychiatric disorders are now the focus of much neurodevelopmental work (see several reviews: Arnold et al., 2005; Buckley et al., 2007; Eisch et al., 2008; Thomas and Peterson, 2008; Jaaro-Peled et al., 2009; Vaccarino et al., 2009).","tracks":[{"project":"TEST0","denotations":[{"id":"20877431-162-170-637112","span":{"begin":891,"end":895},"obj":"[\"15581715\"]"},{"id":"20877431-184-192-637113","span":{"begin":913,"end":917},"obj":"[\"17524622\"]"},{"id":"20877431-204-212-637114","span":{"begin":933,"end":937},"obj":"[\"19005040\"]"},{"id":"20877431-231-239-637115","span":{"begin":960,"end":964},"obj":"[\"18590054\"]"},{"id":"20877431-231-239-637116","span":{"begin":986,"end":990},"obj":"[\"19712980\"]"},{"id":"20877431-231-239-637117","span":{"begin":1010,"end":1014},"obj":"[\"18850329\"]"}],"attributes":[{"subj":"20877431-162-170-637112","pred":"source","obj":"TEST0"},{"subj":"20877431-184-192-637113","pred":"source","obj":"TEST0"},{"subj":"20877431-204-212-637114","pred":"source","obj":"TEST0"},{"subj":"20877431-231-239-637115","pred":"source","obj":"TEST0"},{"subj":"20877431-231-239-637116","pred":"source","obj":"TEST0"},{"subj":"20877431-231-239-637117","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"20877431-15581715-637112","span":{"begin":891,"end":895},"obj":"15581715"},{"id":"20877431-17524622-637113","span":{"begin":913,"end":917},"obj":"17524622"},{"id":"20877431-19005040-637114","span":{"begin":933,"end":937},"obj":"19005040"},{"id":"20877431-18590054-637115","span":{"begin":960,"end":964},"obj":"18590054"},{"id":"20877431-19712980-637116","span":{"begin":986,"end":990},"obj":"19712980"},{"id":"20877431-18850329-637117","span":{"begin":1010,"end":1014},"obj":"18850329"}],"attributes":[{"subj":"20877431-15581715-637112","pred":"source","obj":"0_colil"},{"subj":"20877431-17524622-637113","pred":"source","obj":"0_colil"},{"subj":"20877431-19005040-637114","pred":"source","obj":"0_colil"},{"subj":"20877431-18590054-637115","pred":"source","obj":"0_colil"},{"subj":"20877431-19712980-637116","pred":"source","obj":"0_colil"},{"subj":"20877431-18850329-637117","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"20877431-15581715-38520389","span":{"begin":891,"end":895},"obj":"15581715"},{"id":"20877431-17524622-38520390","span":{"begin":913,"end":917},"obj":"17524622"},{"id":"20877431-19005040-38520391","span":{"begin":933,"end":937},"obj":"19005040"},{"id":"20877431-18590054-38520392","span":{"begin":960,"end":964},"obj":"18590054"},{"id":"20877431-19712980-38520393","span":{"begin":986,"end":990},"obj":"19712980"},{"id":"20877431-18850329-38520394","span":{"begin":1010,"end":1014},"obj":"18850329"}],"attributes":[{"subj":"20877431-15581715-38520389","pred":"source","obj":"2_test"},{"subj":"20877431-17524622-38520390","pred":"source","obj":"2_test"},{"subj":"20877431-19005040-38520391","pred":"source","obj":"2_test"},{"subj":"20877431-18590054-38520392","pred":"source","obj":"2_test"},{"subj":"20877431-19712980-38520393","pred":"source","obj":"2_test"},{"subj":"20877431-18850329-38520394","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93c6ec","default":true},{"id":"0_colil","color":"#e0ec93"},{"id":"2_test","color":"#dd93ec"}]}]}}