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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2944646","sourcedb":"PMC","sourceid":"2944646","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2944646","text":"Another important class of naturally accruing antioxidant are flavonoids or other polyphenols, which also are fairly good antioxidants which reduced oxidative stress in vitro and in vivo. Flavonoids also improve mitochondrial dysfunction and seem to have therapeutical benefit for long-term treatment of age-related cognitive impairment animals and men (Schmitt-Schillig et al., 2005; Schaffer et al., 2006). The significant reduction of the risk in getting AD by Mediterranean diet is very likely explained to an impotent part by the high daily intake of flavonoids (Scarmeas et al., 2006, 2007). In general, even if the effectiveness of those natural occurring antioxidants to protect against AD seems to be limited, they seem to be the major players of diet in reducing oxidative stress and acting as a second however considerably weaker defense system.","tracks":[{"project":"TEST0","denotations":[{"id":"20877425-191-199-198913","span":{"begin":379,"end":383},"obj":"[\"15800383\"]"},{"id":"20877425-214-222-198914","span":{"begin":402,"end":406},"obj":"[\"16917175\"]"},{"id":"20877425-182-190-198915","span":{"begin":591,"end":595},"obj":"[\"17846408\"]"}],"attributes":[{"subj":"20877425-191-199-198913","pred":"source","obj":"TEST0"},{"subj":"20877425-214-222-198914","pred":"source","obj":"TEST0"},{"subj":"20877425-182-190-198915","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"20877425-15800383-198913","span":{"begin":379,"end":383},"obj":"15800383"},{"id":"20877425-16917175-198914","span":{"begin":402,"end":406},"obj":"16917175"},{"id":"20877425-17846408-198915","span":{"begin":591,"end":595},"obj":"17846408"}],"attributes":[{"subj":"20877425-15800383-198913","pred":"source","obj":"0_colil"},{"subj":"20877425-16917175-198914","pred":"source","obj":"0_colil"},{"subj":"20877425-17846408-198915","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"20877425-15800383-38148006","span":{"begin":379,"end":383},"obj":"15800383"},{"id":"20877425-16917175-38148007","span":{"begin":402,"end":406},"obj":"16917175"},{"id":"20877425-17846408-38148008","span":{"begin":591,"end":595},"obj":"17846408"}],"attributes":[{"subj":"20877425-15800383-38148006","pred":"source","obj":"2_test"},{"subj":"20877425-16917175-38148007","pred":"source","obj":"2_test"},{"subj":"20877425-17846408-38148008","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93ecaf","default":true},{"id":"0_colil","color":"#ec9593"},{"id":"2_test","color":"#93aaec"}]}]}}