PMC:2944628 / 24370-25665
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2944628","sourcedb":"PMC","sourceid":"2944628","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2944628","text":"In summary, our results are in line with previous reports showing that middle-aged animals retain limited ability to generate additional new neurons in response to physiological and pathological stimulation (Cameron and McKay, 1999; van Praag et al., 2005; Hattiangady et al., 2008; Rao et al., 2008; Shetty et al., 2010). Specifically, the results reported here indicate that enhancement of neurogenesis in middle-aged animals following injury can be achieved on temporary basis for more than 35 days but less than 90 days. One can speculate that more sustained effect could be obtained with additional trophic support. The list of transmitters and growth factors having influence over neurogenesis is extensive and it is likely that at least some are necessary to sustain neurogenesis at its normal rate (Drapeau and Abrous, 2008). Perhaps the most practical way to supply these factors to the ailing brain is by natural means, e.g., by exposing treated animals to enriched environment and or a training protocol. Cumulative evidence for enriched environment being beneficial for functional recovery after stroke is strong however the causal effect of newly produced neurons for this benefit has not yet been shown (Nithianantharajah and Hannan, 2006) and will require further experimentation.","tracks":[{"project":"TEST0","denotations":[{"id":"20877422-227-235-264489","span":{"begin":227,"end":231},"obj":"[\"10491610\"]"},{"id":"20877422-235-243-264490","span":{"begin":251,"end":255},"obj":"[\"16177036\"]"},{"id":"20877422-227-235-264491","span":{"begin":277,"end":281},"obj":"[\"18241325\"]"},{"id":"20877422-229-237-264492","span":{"begin":295,"end":299},"obj":"[\"18493929\"]"},{"id":"20877422-206-214-264493","span":{"begin":827,"end":831},"obj":"[\"18221417\"]"},{"id":"20877422-232-240-264494","span":{"begin":1248,"end":1252},"obj":"[\"16924259\"]"}],"attributes":[{"subj":"20877422-227-235-264489","pred":"source","obj":"TEST0"},{"subj":"20877422-235-243-264490","pred":"source","obj":"TEST0"},{"subj":"20877422-227-235-264491","pred":"source","obj":"TEST0"},{"subj":"20877422-229-237-264492","pred":"source","obj":"TEST0"},{"subj":"20877422-206-214-264493","pred":"source","obj":"TEST0"},{"subj":"20877422-232-240-264494","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"20877422-10491610-38206201","span":{"begin":227,"end":231},"obj":"10491610"},{"id":"20877422-16177036-38206202","span":{"begin":251,"end":255},"obj":"16177036"},{"id":"20877422-18241325-38206203","span":{"begin":277,"end":281},"obj":"18241325"},{"id":"20877422-18493929-38206204","span":{"begin":295,"end":299},"obj":"18493929"},{"id":"20877422-18221417-38206205","span":{"begin":827,"end":831},"obj":"18221417"},{"id":"20877422-16924259-38206206","span":{"begin":1248,"end":1252},"obj":"16924259"}],"attributes":[{"subj":"20877422-10491610-38206201","pred":"source","obj":"2_test"},{"subj":"20877422-16177036-38206202","pred":"source","obj":"2_test"},{"subj":"20877422-18241325-38206203","pred":"source","obj":"2_test"},{"subj":"20877422-18493929-38206204","pred":"source","obj":"2_test"},{"subj":"20877422-18221417-38206205","pred":"source","obj":"2_test"},{"subj":"20877422-16924259-38206206","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"20877422-10491610-264489","span":{"begin":227,"end":231},"obj":"10491610"},{"id":"20877422-16177036-264490","span":{"begin":251,"end":255},"obj":"16177036"},{"id":"20877422-18241325-264491","span":{"begin":277,"end":281},"obj":"18241325"},{"id":"20877422-18493929-264492","span":{"begin":295,"end":299},"obj":"18493929"},{"id":"20877422-18221417-264493","span":{"begin":827,"end":831},"obj":"18221417"},{"id":"20877422-16924259-264494","span":{"begin":1248,"end":1252},"obj":"16924259"}],"attributes":[{"subj":"20877422-10491610-264489","pred":"source","obj":"0_colil"},{"subj":"20877422-16177036-264490","pred":"source","obj":"0_colil"},{"subj":"20877422-18241325-264491","pred":"source","obj":"0_colil"},{"subj":"20877422-18493929-264492","pred":"source","obj":"0_colil"},{"subj":"20877422-18221417-264493","pred":"source","obj":"0_colil"},{"subj":"20877422-16924259-264494","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#bdec93","default":true},{"id":"2_test","color":"#ec93d7"},{"id":"0_colil","color":"#93ece6"}]}]}}