PMC:2940023 / 17750-20257 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2940023","sourcedb":"PMC","sourceid":"2940023","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2940023","text":"Reclassification tables for the Diamond \u0026 Forrester model and the Pryor model are presented in Tables 4 and 5. The addition of CTCS to Diamond \u0026 Forrester resulted in reclassification of 47.2% of patients of whom 73.3% were correctly reclassified. The reclassification calibration statistic (RCS) indicated a strong lack of fit for the Diamond \u0026 Forrester model (p \u003c 0.00001) which decreased substantially when CTCS was added to the model (p \u003c 0.01). The NRI (net reclassification improvement) was 33.6% (p \u003c 0.0001) and the IDI (integrated discrimination improvement) was also statistically significant (18.8%, p \u003c 0.001) indicating improvement in the classification of cases and non-cases in probability categories and improvement in discrimination between cases and non-cases.\nTable 4 Probability of coronary artery disease: reclassification table after addition of CTCS to the Diamond and Forrester (model 1)\nProbability category based on model 1 Probability category based on model 1 + CTCS Total, n (%)\n\u003c30% ≥30–50% ≥50–70% ≥70%\n\u003c30%\n N (%) 51 (67.1) 19 (25.0%) 4 (5.2) 2 (2.6) 76 (29.9)\n Observed probability, % 11.8 36.8 50.0 100.0 22.4\n≥30–50%\n N (%) 25 (39.7) 13 (20.6) 19 (30.2) 6 (9.5) 63 (28.4)\n Observed probability, % 0.0 23.1 68.4 50.0 30.2\n≥50–70%\n N (%) 4 (11.1) 5 (13.9) 6 (16.7) 21 (58.3) 36 (14.2)\n Observed probability, % 25 80.0 50.0 66.7 61.1\n≥70%\n N (%) 5 (6.3) 2 (2.5) 8 (10.1) 64 (81.0) 79 (31.1)\n Observed probability, % 0.0 50.0 37.5 95.3 82.3\n \nTotal\n N (%) 85 (33.5) 39 (15.4) 37 (14.6) 93 (36.6) 254 (100.0)\n Observed probability, % 8.2 38.5 56.8 86.0 48.4\nCTCS computed tomography coronary calcium score\nTable 5 Probability of coronary artery disease: reclassification table after addition of CTCS to the model published by Pryor et al. (model 2)\nProbability category based on model 2 Probability category based on model 2 + CTCS Total, n (%)\n\u003c30% ≥30–50% ≥50–70% ≥70%\n\u003c30%\n N (%) 76 (85.4) 10 (11.2) 2 (2.3) 1 (1.1) 89 (35.0)\n Observed probability, % 9.2 40.0 100.0 100.0 15.7\n≥30–50%\n N (%) 10 (27.0) 10 (27.0) 12 (32.4) 5 (13.5) 37 (14.6)\n Observed probability, % 10.0 20.0 50.0 100.0 37.8\n≥50–70%\n N (%) 7 (13.5) 6 (11.5) 15 (28.9) 24 (46.2) 52 (20.5)\n Observed probability, % 0.0 50.0 73.3 66.7 57.7\n≥70%\n N (%) 3 (4.0) 3 (4.0) 9 (11.8) 61 (80.3) 76 (29.9)\n Observed probability, % 33.3 0.0 66.7 95.0 85.5\n \nTotal\n N (%) 96 (37.8) 29 (11.4) 38 (15.0) 91 (35.8) 254 (100.0)\n Observed probability, % 9.4 31.0 65.8 87.9 48.4\nCTCS computed tomography coronary calcium 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