PMC:2940021 / 28751-30138
Annnotations
0_colil
{"project":"0_colil","denotations":[{"id":"20422195-1822774-60971","span":{"begin":266,"end":268},"obj":"1822774"},{"id":"20422195-16511650-60972","span":{"begin":816,"end":818},"obj":"16511650"},{"id":"20422195-8293736-60973","span":{"begin":820,"end":822},"obj":"8293736"},{"id":"20422195-8423464-60974","span":{"begin":824,"end":826},"obj":"8423464"},{"id":"20422195-8293736-60975","span":{"begin":932,"end":934},"obj":"8293736"},{"id":"20422195-2996109-60976","span":{"begin":936,"end":938},"obj":"2996109"}],"text":"Myotonic dystrophy types 1 and 2 (DM1, DM2) are autosomal dominantly inherited multisystem disorders and genetically characterised by pathogenic repeat mutations. DM1 is—with an estimated prevalence of 1 in 8,000—the second most common muscular dystrophy worldwide [52]. The clinical phenotype and pattern of muscle affliction differ between DM1 and DM2 (or proximal myotonic myopathy = PROMM) but also show some overlap. Almost all DM1 patients show signs of fatty degeneration and/or oedematous changes in the striated muscles on muscular MRI. Most of the patients show severe fatty degeneration of the proximal and distal lower limb muscles. There is a predominant affliction of the anterior compartment of the thighs compared with the posterior compartment with a relative sparing of the rectus femoris muscles [27, 53, 54]. Particularly, the vastus muscles frequently show a semi-lunar peri-femoral area of fatty degeneration [53, 55]. In the lower legs of DM1 patients, the gastrocnemius muscles show early and frequent involvement, whereas the posterior tibial muscles are relatively unaffected. In addition, whole-body MRI protocols can frequently detect the involvement of other organs in DM1 patients. Dypshagia is a common clinical finding in DM1 patients, which is reflected by a substantial dilatation of the oesophagus that can be easily detected and rated on MRI (Fig. 2)."}
2_test
{"project":"2_test","denotations":[{"id":"20422195-1822774-29368055","span":{"begin":266,"end":268},"obj":"1822774"},{"id":"20422195-16511650-29368056","span":{"begin":816,"end":818},"obj":"16511650"},{"id":"20422195-8293736-29368057","span":{"begin":820,"end":822},"obj":"8293736"},{"id":"20422195-8423464-29368058","span":{"begin":824,"end":826},"obj":"8423464"},{"id":"20422195-8293736-29368059","span":{"begin":932,"end":934},"obj":"8293736"},{"id":"20422195-2996109-29368060","span":{"begin":936,"end":938},"obj":"2996109"}],"text":"Myotonic dystrophy types 1 and 2 (DM1, DM2) are autosomal dominantly inherited multisystem disorders and genetically characterised by pathogenic repeat mutations. DM1 is—with an estimated prevalence of 1 in 8,000—the second most common muscular dystrophy worldwide [52]. The clinical phenotype and pattern of muscle affliction differ between DM1 and DM2 (or proximal myotonic myopathy = PROMM) but also show some overlap. Almost all DM1 patients show signs of fatty degeneration and/or oedematous changes in the striated muscles on muscular MRI. Most of the patients show severe fatty degeneration of the proximal and distal lower limb muscles. There is a predominant affliction of the anterior compartment of the thighs compared with the posterior compartment with a relative sparing of the rectus femoris muscles [27, 53, 54]. Particularly, the vastus muscles frequently show a semi-lunar peri-femoral area of fatty degeneration [53, 55]. In the lower legs of DM1 patients, the gastrocnemius muscles show early and frequent involvement, whereas the posterior tibial muscles are relatively unaffected. In addition, whole-body MRI protocols can frequently detect the involvement of other organs in DM1 patients. Dypshagia is a common clinical finding in DM1 patients, which is reflected by a substantial dilatation of the oesophagus that can be easily detected and rated on MRI (Fig. 2)."}
TEST0
{"project":"TEST0","denotations":[{"id":"20422195-103-109-60971","span":{"begin":266,"end":268},"obj":"[\"1822774\"]"},{"id":"20422195-171-177-60972","span":{"begin":816,"end":818},"obj":"[\"16511650\"]"},{"id":"20422195-175-181-60973","span":{"begin":820,"end":822},"obj":"[\"8293736\"]"},{"id":"20422195-179-185-60974","span":{"begin":824,"end":826},"obj":"[\"8423464\"]"},{"id":"20422195-103-109-60975","span":{"begin":932,"end":934},"obj":"[\"8293736\"]"},{"id":"20422195-107-113-60976","span":{"begin":936,"end":938},"obj":"[\"2996109\"]"}],"text":"Myotonic dystrophy types 1 and 2 (DM1, DM2) are autosomal dominantly inherited multisystem disorders and genetically characterised by pathogenic repeat mutations. DM1 is—with an estimated prevalence of 1 in 8,000—the second most common muscular dystrophy worldwide [52]. The clinical phenotype and pattern of muscle affliction differ between DM1 and DM2 (or proximal myotonic myopathy = PROMM) but also show some overlap. Almost all DM1 patients show signs of fatty degeneration and/or oedematous changes in the striated muscles on muscular MRI. Most of the patients show severe fatty degeneration of the proximal and distal lower limb muscles. There is a predominant affliction of the anterior compartment of the thighs compared with the posterior compartment with a relative sparing of the rectus femoris muscles [27, 53, 54]. Particularly, the vastus muscles frequently show a semi-lunar peri-femoral area of fatty degeneration [53, 55]. In the lower legs of DM1 patients, the gastrocnemius muscles show early and frequent involvement, whereas the posterior tibial muscles are relatively unaffected. In addition, whole-body MRI protocols can frequently detect the involvement of other organs in DM1 patients. Dypshagia is a common clinical finding in DM1 patients, which is reflected by a substantial dilatation of the oesophagus that can be easily detected and rated on MRI (Fig. 2)."}
MyTest
{"project":"MyTest","denotations":[{"id":"20422195-1822774-29368055","span":{"begin":266,"end":268},"obj":"1822774"},{"id":"20422195-16511650-29368056","span":{"begin":816,"end":818},"obj":"16511650"},{"id":"20422195-8293736-29368057","span":{"begin":820,"end":822},"obj":"8293736"},{"id":"20422195-8423464-29368058","span":{"begin":824,"end":826},"obj":"8423464"},{"id":"20422195-8293736-29368059","span":{"begin":932,"end":934},"obj":"8293736"},{"id":"20422195-2996109-29368060","span":{"begin":936,"end":938},"obj":"2996109"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Myotonic dystrophy types 1 and 2 (DM1, DM2) are autosomal dominantly inherited multisystem disorders and genetically characterised by pathogenic repeat mutations. DM1 is—with an estimated prevalence of 1 in 8,000—the second most common muscular dystrophy worldwide [52]. The clinical phenotype and pattern of muscle affliction differ between DM1 and DM2 (or proximal myotonic myopathy = PROMM) but also show some overlap. Almost all DM1 patients show signs of fatty degeneration and/or oedematous changes in the striated muscles on muscular MRI. Most of the patients show severe fatty degeneration of the proximal and distal lower limb muscles. There is a predominant affliction of the anterior compartment of the thighs compared with the posterior compartment with a relative sparing of the rectus femoris muscles [27, 53, 54]. Particularly, the vastus muscles frequently show a semi-lunar peri-femoral area of fatty degeneration [53, 55]. In the lower legs of DM1 patients, the gastrocnemius muscles show early and frequent involvement, whereas the posterior tibial muscles are relatively unaffected. In addition, whole-body MRI protocols can frequently detect the involvement of other organs in DM1 patients. Dypshagia is a common clinical finding in DM1 patients, which is reflected by a substantial dilatation of the oesophagus that can be easily detected and rated on MRI (Fig. 2)."}