PMC:2940021 / 21493-22266
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2940021","sourcedb":"PMC","sourceid":"2940021","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2940021","text":"Dysferlinopathies, which are genetically characterised by mutations in the dysferlin gene lead to LGMD 2B, distal Miyoshi myopathies and a form of distal anterior compartment myopathy [42, 43]. On MRI, symptomatic patients with dysferlinopathies present with severe dystrophic changes in the anterior and posterior compartments of the thighs with a characteristic sparing of the gracilis and sartorius muscles. In the lower legs, dysferlinopathies predominantly affect the posterior compartment with a relative sparing of the medial head of the gastrocnemius muscle [44–46]. This distinct pattern is different from muscle involvement in LGMD2I and LGMD2A patients in which dystrophic changes in the posterior thigh and posterior calf muscle can frequently be observed [40].","tracks":[{"project":"0_colil","denotations":[{"id":"20422195-9731526-60959","span":{"begin":185,"end":187},"obj":"9731526"},{"id":"20422195-11198284-60960","span":{"begin":189,"end":191},"obj":"11198284"},{"id":"20422195-15726252-60962","span":{"begin":769,"end":771},"obj":"15726252"},{"id":"20422195-17287450-60961","span":{"begin":567,"end":569},"obj":"17287450"},{"id":"20422195-19154541-60961","span":{"begin":567,"end":569},"obj":"19154541"},{"id":"20422195-9673986-60961","span":{"begin":567,"end":569},"obj":"9673986"}],"attributes":[{"subj":"20422195-9731526-60959","pred":"source","obj":"0_colil"},{"subj":"20422195-11198284-60960","pred":"source","obj":"0_colil"},{"subj":"20422195-15726252-60962","pred":"source","obj":"0_colil"},{"subj":"20422195-17287450-60961","pred":"source","obj":"0_colil"},{"subj":"20422195-19154541-60961","pred":"source","obj":"0_colil"},{"subj":"20422195-9673986-60961","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"20422195-9731526-29368043","span":{"begin":185,"end":187},"obj":"9731526"},{"id":"20422195-11198284-29368044","span":{"begin":189,"end":191},"obj":"11198284"},{"id":"20422195-17287450-29368045","span":{"begin":567,"end":569},"obj":"17287450"},{"id":"20422195-9673986-29368045","span":{"begin":567,"end":569},"obj":"9673986"},{"id":"20422195-19154541-29368045","span":{"begin":567,"end":569},"obj":"19154541"},{"id":"20422195-15726252-29368046","span":{"begin":769,"end":771},"obj":"15726252"}],"attributes":[{"subj":"20422195-9731526-29368043","pred":"source","obj":"2_test"},{"subj":"20422195-11198284-29368044","pred":"source","obj":"2_test"},{"subj":"20422195-17287450-29368045","pred":"source","obj":"2_test"},{"subj":"20422195-9673986-29368045","pred":"source","obj":"2_test"},{"subj":"20422195-19154541-29368045","pred":"source","obj":"2_test"},{"subj":"20422195-15726252-29368046","pred":"source","obj":"2_test"}]},{"project":"TEST0","denotations":[{"id":"20422195-185-191-60959","span":{"begin":185,"end":187},"obj":"[\"9731526\"]"},{"id":"20422195-189-195-60960","span":{"begin":189,"end":191},"obj":"[\"11198284\"]"},{"id":"20422195-156-162-60961","span":{"begin":567,"end":569},"obj":"[\"17287450\", \"9673986\", \"19154541\"]"},{"id":"20422195-194-200-60962","span":{"begin":769,"end":771},"obj":"[\"15726252\"]"}],"attributes":[{"subj":"20422195-185-191-60959","pred":"source","obj":"TEST0"},{"subj":"20422195-189-195-60960","pred":"source","obj":"TEST0"},{"subj":"20422195-156-162-60961","pred":"source","obj":"TEST0"},{"subj":"20422195-194-200-60962","pred":"source","obj":"TEST0"}]},{"project":"MyTest","denotations":[{"id":"20422195-9731526-29368043","span":{"begin":185,"end":187},"obj":"9731526"},{"id":"20422195-11198284-29368044","span":{"begin":189,"end":191},"obj":"11198284"},{"id":"20422195-17287450-29368045","span":{"begin":567,"end":569},"obj":"17287450"},{"id":"20422195-9673986-29368045","span":{"begin":567,"end":569},"obj":"9673986"},{"id":"20422195-19154541-29368045","span":{"begin":567,"end":569},"obj":"19154541"},{"id":"20422195-15726252-29368046","span":{"begin":769,"end":771},"obj":"15726252"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"20422195-9731526-29368043","pred":"source","obj":"MyTest"},{"subj":"20422195-11198284-29368044","pred":"source","obj":"MyTest"},{"subj":"20422195-17287450-29368045","pred":"source","obj":"MyTest"},{"subj":"20422195-9673986-29368045","pred":"source","obj":"MyTest"},{"subj":"20422195-19154541-29368045","pred":"source","obj":"MyTest"},{"subj":"20422195-15726252-29368046","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"0_colil","color":"#a6ec93","default":true},{"id":"2_test","color":"#ec93c0"},{"id":"TEST0","color":"#93daec"},{"id":"MyTest","color":"#ece393"}]}]}}