PMC:2940017 / 18617-20532
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2940017","sourcedb":"PMC","sourceid":"2940017","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2940017","text":"Gliomas, the most frequent cerebral tumours in adults, exhibit varying degrees of cellular and nuclear pleomorphism, mitotic activity, vascular proliferation and necrosis [24, 25]. This histopathological heterogeneity explains the difficulties concerning the preoperative assessment and biopsy and thus histopathological grading. Histopathological assessment of tissue, the current standard for tumour grading, presents inherent limitations, including sampling errors, intra-observer variation and the changing nature of central nervous system tumours [26, 27]. Accurate histopathological diagnosis is crucial to define the appropriate management and prognosis according to tumour grade. For low-grade gliomas, conservative treatment and monitoring for detecting transformation or active proliferation are of great importance. Because the degree of vascular proliferation is one of the most critical elements in the determination of tumour grade and prognosis, the preoperative non-invasive assessment and quantification of glioma vascularity can be helpful to determine the malignant potential of the tumour, to select an appropriate biopsy site, to evaluate transition from low-grade to a high-grade glioma, and also to monitor treatment response [28]. Despite the small number of patients with low-grade gliomas, our data implicate that high-grade gliomas could be differentiated from low-grade gliomas on the basis of all three PCT parameters studied. Low-grade gliomas exhibited no different perfusion parameters compared with normal parenchyma (Fig. 6).\nFig. 6 A 42-year-old man with histopathological diagnosis of low-grade glioma WHO II. The contrast-enhanced MIP image (a) shows no enhancement within the tumour in the right frontal lobe (1). The perfusion maps reveal no significant difference in the perfusion parameters CBF (b), CBV (c) and K Trans (d) between the lesion (1) and the unaffected side (2)","divisions":[{"label":"label","span":{"begin":1560,"end":1566}}],"tracks":[{"project":"TEST0","denotations":[{"id":"20495977-172-178-67290","span":{"begin":172,"end":174},"obj":"[\"2990664\"]"},{"id":"20495977-223-229-67291","span":{"begin":553,"end":555},"obj":"[\"3553757\"]"},{"id":"20495977-229-235-67292","span":{"begin":1250,"end":1252},"obj":"[\"9049887\"]"}],"attributes":[{"subj":"20495977-172-178-67290","pred":"source","obj":"TEST0"},{"subj":"20495977-223-229-67291","pred":"source","obj":"TEST0"},{"subj":"20495977-229-235-67292","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"20495977-2990664-67290","span":{"begin":172,"end":174},"obj":"2990664"},{"id":"20495977-3553757-67291","span":{"begin":553,"end":555},"obj":"3553757"},{"id":"20495977-9049887-67292","span":{"begin":1250,"end":1252},"obj":"9049887"}],"attributes":[{"subj":"20495977-2990664-67290","pred":"source","obj":"0_colil"},{"subj":"20495977-3553757-67291","pred":"source","obj":"0_colil"},{"subj":"20495977-9049887-67292","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"20495977-2990664-29373475","span":{"begin":172,"end":174},"obj":"2990664"},{"id":"20495977-3553757-29373476","span":{"begin":553,"end":555},"obj":"3553757"},{"id":"20495977-9049887-29373477","span":{"begin":1250,"end":1252},"obj":"9049887"}],"attributes":[{"subj":"20495977-2990664-29373475","pred":"source","obj":"2_test"},{"subj":"20495977-3553757-29373476","pred":"source","obj":"2_test"},{"subj":"20495977-9049887-29373477","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"20495977-2990664-29373475","span":{"begin":172,"end":174},"obj":"2990664"},{"id":"20495977-3553757-29373476","span":{"begin":553,"end":555},"obj":"3553757"},{"id":"20495977-9049887-29373477","span":{"begin":1250,"end":1252},"obj":"9049887"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"20495977-2990664-29373475","pred":"source","obj":"MyTest"},{"subj":"20495977-3553757-29373476","pred":"source","obj":"MyTest"},{"subj":"20495977-9049887-29373477","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#ecbf93","default":true},{"id":"0_colil","color":"#a593ec"},{"id":"2_test","color":"#9aec93"},{"id":"MyTest","color":"#ec93b4"}]}]}}