PMC:2935892 / 1136-1537 JSONTXT

{"project":"Biotea","denotations":[{"id":"T54","span":{"begin":219,"end":224},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612"},{"id":"T58","span":{"begin":219,"end":224},"obj":"http://purl.bioontology.org/ontology/MESH/D005796"},{"id":"T75","span":{"begin":134,"end":141},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64858"},{"id":"T78","span":{"begin":134,"end":141},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T80","span":{"begin":134,"end":141},"obj":"http://purl.obolibrary.org/obo/GO_0003675"},{"id":"T82","span":{"begin":134,"end":141},"obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"T84","span":{"begin":134,"end":141},"obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"T86","span":{"begin":134,"end":141},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000148318"},{"id":"T88","span":{"begin":134,"end":141},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T90","span":{"begin":134,"end":141},"obj":"http://purl.obolibrary.org/obo/PR_000000001"},{"id":"T92","span":{"begin":134,"end":141},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41172"},{"id":"T94","span":{"begin":134,"end":141},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/88878007"},{"id":"T96","span":{"begin":134,"end":141},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10036987"},{"id":"T135","span":{"begin":211,"end":218},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16885"},{"id":"T137","span":{"begin":211,"end":218},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45576"},{"id":"T151","span":{"begin":286,"end":294},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116358"},{"id":"T154","span":{"begin":353,"end":364},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25277"},{"id":"T157","span":{"begin":353,"end":364},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/262202000"},{"id":"T210","span":{"begin":226,"end":235},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/55919000"},{"id":"T240","span":{"begin":257,"end":262},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52160"},{"id":"T242","span":{"begin":257,"end":262},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17495"},{"id":"T244","span":{"begin":257,"end":262},"obj":"http://purl.obolibrary.org/obo/PR_000007123"},{"id":"T246","span":{"begin":257,"end":262},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18384"},{"id":"T248","span":{"begin":267,"end":272},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26166"},{"id":"T250","span":{"begin":267,"end":272},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C24367"},{"id":"T252","span":{"begin":267,"end":272},"obj":"http://purl.obolibrary.org/obo/PR_000007130"},{"id":"T254","span":{"begin":267,"end":272},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52164"},{"id":"T272","span":{"begin":50,"end":60},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/7882003"},{"id":"T273","span":{"begin":50,"end":60},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25737"},{"id":"T274","span":{"begin":77,"end":89},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C133995"},{"id":"T276","span":{"begin":77,"end":89},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28041"},{"id":"T277","span":{"begin":77,"end":89},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28296"},{"id":"T278","span":{"begin":90,"end":100},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25214"},{"id":"T279","span":{"begin":106,"end":118},"obj":"http://purl.obolibrary.org/obo/GO_0051179"},{"id":"T280","span":{"begin":106,"end":118},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28264"},{"id":"T281","span":{"begin":126,"end":133},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/900000000000073002"},{"id":"T282","span":{"begin":126,"end":133},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C151401"},{"id":"T283","span":{"begin":126,"end":133},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C42777"},{"id":"T284","span":{"begin":134,"end":149},"obj":"http://purl.bioontology.org/ontology/MESH/D000072417"},{"id":"T285","span":{"begin":160,"end":170},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75924"},{"id":"T286","span":{"begin":160,"end":170},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/40143009"},{"id":"T287","span":{"begin":160,"end":170},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25518"},{"id":"T288","span":{"begin":171,"end":180},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70664"},{"id":"T289","span":{"begin":240,"end":248},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000146989"},{"id":"T290","span":{"begin":240,"end":248},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122159"},{"id":"T291","span":{"begin":240,"end":248},"obj":"http://purl.bioontology.org/ontology/NDDF/003449"},{"id":"T292","span":{"begin":240,"end":248},"obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"T293","span":{"begin":240,"end":248},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/418246001"},{"id":"T294","span":{"begin":240,"end":248},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/27378009"},{"id":"T295","span":{"begin":240,"end":248},"obj":"http://purl.bioontology.org/ontology/MESH/D014443"},{"id":"T296","span":{"begin":240,"end":248},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C915"},{"id":"T297","span":{"begin":298,"end":313},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16974"},{"id":"T298","span":{"begin":298,"end":313},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/56183000"},{"id":"T299","span":{"begin":314,"end":326},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16197"},{"id":"T300","span":{"begin":314,"end":326},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25218"},{"id":"T301","span":{"begin":337,"end":346},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67045"},{"id":"T302","span":{"begin":347,"end":352},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25586"},{"id":"T270","span":{"begin":12,"end":24},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61040"},{"id":"T271","span":{"begin":12,"end":24},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41130"},{"id":"T275","span":{"begin":77,"end":89},"obj":"http://purl.obolibrary.org/obo/IAO_0000317"}],"namespaces":[{"prefix":"omim","uri":"http://purl.bioontology.org/ontology/OMIM/"},{"prefix":"pr","uri":"http://purl.obolibrary.org/obo/PR_"}],"text":"Conclusions/Significance\nAlthough the alterations identified require further experimental evaluation, the localization within defined protein domains indicates functional relevance for most of them. Some of the mutated genes, including the tyrosine kinases EPHA3 and EPHB2, are clearly amenable to pharmacological intervention and could represent novel therapeutic targets for these incurable cancers."}