PMC:29011 / 7595-10115
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/29011","sourcedb":"PMC","sourceid":"29011","source_url":"http://www.ncbi.nlm.nih.gov/pmc/29011","text":"Results\nThe mean age of the normal subjects was 24 ± 1.56 years and \t\t 37.7 ± 4.27 years in the renal transplant subjects (P \u003c 0.01). \t\t There was a significant rise in the mean PI in the controls with the addition \t\t of CPAP (P \u003c 0.001; Table 1, Fig \t\t 1). Using non-parametric testing, there was no \t\t significant change in PI between 0 and 2.5 cmH2O CPAP (Table \t\t 1). However, between 0 and 5.0 cmH2O CPAP, PI \t\t increased from 0.65 ± 0.06 to 0.7 ± 0.08 (P \u003c 0.05), \t\t indicating that the application of CPAP caused an increase in renal vascular \t\t resistance and therefore a fall in renal blood flow. This increase in PI \t\t occurred in all except one subject. Between 0 and 7.5 cmH2O CPAP, \t\t there was a further rise in PI in all normal subjects to a mean of 0.82 ± \t\t 0.08 (P \u003c 0.01). The increase in PI between 5.0 and \t\t 7.5 cmH2O CPAP was also significant (P \u003c 0.05). The \t\t increase in PI was usually evident within 10 min of the application of CPAP. The \t\t renal transplant subjects had a higher baseline PI than the normal subjects \t\t (1.15 ± 0.18 compared to 0.65 ± 0.06, P \u003c 0.05; Table \t\t 1). The PI increased significantly in all the transplant \t\t subjects with 5.0 and 7.5 cmH2O CPAP (Table 1, \t\t Fig 1).\nWe compared the rise in PI with the application of CPAP between the \t\t normal and transplant subjects (Table 1). The increase in \t\t PI in response to 5.0 cmH2O CPAP was greater in the transplant \t\t subjects but this was not significant. Furthermore, there was no difference \t\t between the groups in the response to 7.5 cmH2O CPAP. However, when \t\t expressed in terms of percentage change in PI from baseline values, the \t\t increase in PI with 5.0 cmH2O was 7.7% in controls compared to 7.8% \t\t in the transplant subjects and, with 7.5 cmH2O CPAP, the increase was \t\t 26% in the controls compared to 20% in the transplant subjects.\nSystolic blood pressure did not change in the controls between 0 and \t\t 5.0cmH2O CPAP (115 ± 9.26 mmHg and 109 ± 8.63 mmHg, \t\t respectively; NS). However, the systolic blood pressure fell to 104 ± \t\t 11.0 mmHg on 7.5 cmH2O CPAP, which approached statistical significance \t\t (P = 0.06). Diastolic blood pressure fell significantly on \t\t 7.5 cmH2O CPAP, from 76.43 ± 8.84 mmHg at baseline to 72.9 ± \t\t 9.32 mmHg (P \u003c 0.01). In the transplant subjects, there was no \t\t significant change in either systolic or diastolic blood pressure during the \t\t application of CPAP. Furthermore, there was no significant change in heart rate \t\t in all patients throughout the study.","divisions":[{"label":"Title","span":{"begin":0,"end":7}}],"tracks":[]}