PMC:29011 / 3015-4477 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/29011","sourcedb":"PMC","sourceid":"29011","source_url":"http://www.ncbi.nlm.nih.gov/pmc/29011","text":"Subjects\nTen normal subjects and six renal transplant patients were studied. \t\t\t All participants were male. Each subject gave informed consent and the hospital \t\t\t ethics committee approved the study. The normal subjects were recruited from \t\t\t the medical staff with a mean ± SD age of 24 ± 1.56 years and none of \t\t\t them were on medication. Six male patients with renal allografts for treatment \t\t\t of chronic renal failure were randomly recruited from the nephrology outpatient \t\t\t department. They were at least 18 months post renal transplantation (mean 30 \t\t\t months) with an average age of 37.7 ± 4.27 years. Each patient had a stable \t\t\t renal function, with serum creatinine level \u003c 200mmol/l and no recent renal \t\t\t complications. All patients were on immunosuppressive therapy which included \t\t\t prednisolone, azothioprine and cyclosporin. Seven of the patients were on \t\t\t antihypertensive medication, consisting of a beta-blocker in five cases and \t\t\t nitrates in two. None of them had a history of cardiac or respiratory \t\t\t disease.\nEach subject was studied at a similar time each day. CPAP was \t\t\t delivered via tight-fitting full-face mask by a continuous-flow system using a \t\t\t Downs flow generator (Vital Signs, Boston, Massachusetts, USA). CPAP was \t\t\t started at a level of 2.5 cmH2O and increased by increments of \t\t\t 2.5 cmH2O to a maximum of 7.5 cmH2O. CPAP was applied for \t\t\t 20 min at each of the three sequential pressure settings.","divisions":[{"label":"Title","span":{"begin":0,"end":8}}],"tracks":[]}