> top > docs > PMC:2889865 > spans > 80-2471 > annotations

PMC:2889865 / 80-2471 JSONTXT

Annnotations TAB JSON ListView MergeView

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T549 0-10 NN denotes Background
T550 11-20 NN denotes Activator
T551 21-28 NN denotes protein
T552 29-30 -LRB- denotes (
T553 30-32 NN denotes AP
T554 32-33 -RRB- denotes )
T555 33-35 CD denotes -1
T556 36-39 CC denotes and
T557 40-47 JJ denotes nuclear
T558 48-54 NN denotes factor
T559 55-56 -LRB- denotes (
T560 56-58 NN denotes NF
T561 58-59 -RRB- denotes )
T562 59-62 NN denotes -κB
T563 63-70 RB denotes largely
T564 71-78 VB denotes control
T565 79-85 NN denotes T-cell
T566 86-96 NN denotes activation
T567 96-97 -COMMA- denotes ,
T568 98-107 VB denotes following
T569 108-115 NN denotes binding
T570 116-118 IN denotes of
T571 119-126 JJ denotes foreign
T572 127-135 NN denotes antigens
T573 136-138 TO denotes to
T574 139-142 DT denotes the
T575 143-149 NN denotes T-cell
T576 150-158 NN denotes receptor
T577 159-166 VB denotes leading
T578 167-169 TO denotes to
T579 170-178 NN denotes cytokine
T580 179-188 NN denotes secretion
T581 190-198 JJ denotes Elevated
T582 199-205 NN denotes levels
T583 206-208 IN denotes of
T584 209-225 JJ denotes pro-inflammatory
T585 226-235 NN denotes cytokines
T586 236-239 CC denotes and
T587 240-250 NN denotes chemokines
T588 251-255 JJ denotes such
T589 256-258 IN denotes as
T590 259-262 NN denotes TNF
T591 262-263 -COMMA- denotes ,
T592 264-268 NN denotes IL-6
T593 269-272 CC denotes and
T594 273-278 NN denotes CXCL8
T595 279-282 VB denotes are
T596 283-293 VB denotes associated
T597 294-298 IN denotes with
T598 299-306 JJ denotes several
T599 307-312 JJ denotes human
T600 313-321 NN denotes diseases
T601 322-331 VB denotes including
T602 332-338 JJ denotes cystic
T603 339-347 NN denotes fibrosis
T604 347-348 -COMMA- denotes ,
T605 349-358 JJ denotes pulmonary
T606 359-367 NN denotes fibrosis
T607 368-371 CC denotes and
T608 372-376 NN denotes AIDS
T609 378-381 DT denotes The
T610 382-385 NN denotes aim
T611 386-388 IN denotes of
T612 389-393 DT denotes this
T613 394-399 NN denotes study
T614 400-403 VB denotes was
T615 404-406 TO denotes to
T616 407-418 VB denotes investigate
T617 419-422 DT denotes the
T618 423-427 NN denotes role
T619 428-430 IN denotes of
T620 431-434 DT denotes the
T621 435-448 NN denotes transcription
T622 449-456 NN denotes factors
T623 456-457 -COMMA- denotes ,
T624 458-462 NN denotes AP-1
T625 463-466 CC denotes and
T626 467-472 NN denotes NF-κB
T627 472-473 -COMMA- denotes ,
T628 474-476 IN denotes in
T629 477-481 NN denotes IL-6
T630 482-485 CC denotes and
T631 486-491 NN denotes CXCL8
T632 492-502 NN denotes regulation
T633 503-505 IN denotes in
T634 506-512 NN denotes Jurkat
T635 513-520 NN denotes T-cells
T636 523-530 NN denotes Results
T637 531-538 NN denotes Phorbol
T638 539-548 NN denotes myristate
T639 549-556 NN denotes acetate
T640 557-558 -LRB- denotes (
T641 558-561 NN denotes PMA
T642 561-562 -RRB- denotes )
T643 563-571 NN denotes exposure
T644 572-580 VB denotes resulted
T645 581-583 IN denotes in
T646 584-586 DT denotes an
T647 587-600 NN denotes up-regulation
T648 601-603 IN denotes of
T649 604-608 NN denotes AP-1
T650 609-612 CC denotes and
T651 613-628 NN denotes down-regulation
T652 629-631 IN denotes of
T653 632-637 NN denotes NF-κB
T654 638-646 NN denotes activity
T655 646-647 -COMMA- denotes ,
T656 648-655 RB denotes however
T657 655-656 -COMMA- denotes ,
T658 657-665 NN denotes exposure
T659 666-668 TO denotes to
T660 669-673 NN denotes heat
T661 674-680 VB denotes killed
T662 681-682 -LRB- denotes (
T663 682-684 NN denotes HK
T664 684-685 -RRB- denotes )
T665 686-698 FW denotes Escherichia.
T666 699-703 FW denotes coli
T667 704-710 NN denotes MG1655
T668 711-719 VB denotes resulted
T669 720-722 IN denotes in
T670 723-724 DT denotes a
T671 725-739 JJ denotes dose-dependent
T672 740-748 NN denotes increase
T673 749-751 IN denotes in
T674 752-757 NN denotes NF-κB
T675 758-766 NN denotes activity
T676 767-774 IN denotes without
T677 775-784 VB denotes affecting
T678 785-789 NN denotes AP-1
T679 791-794 DT denotes The
T680 795-803 NN denotes cytokine
T681 804-811 NN denotes profile
T682 812-820 VB denotes revealed
T683 821-823 DT denotes an
T684 824-837 NN denotes up-regulation
T685 838-840 IN denotes of
T686 841-844 DT denotes the
T687 845-854 NN denotes chemokine
T688 855-860 NN denotes CXCL8
T689 861-864 CC denotes and
T690 865-868 DT denotes the
T691 869-885 JJ denotes pro-inflammatory
T692 886-895 NN denotes cytokines
T693 896-899 NN denotes TNF
T694 899-900 -COMMA- denotes ,
T695 901-905 NN denotes IL-2
T696 906-909 CC denotes and
T697 910-914 NN denotes IL-6
T698 915-924 VB denotes following
T699 925-934 NN denotes treatment
T700 935-939 IN denotes with
T701 940-944 CC denotes both
T702 945-948 NN denotes PMA
T703 949-952 CC denotes and
T704 953-955 NN denotes HK
T705 956-958 FW denotes E.
T706 959-963 FW denotes coli
T707 963-964 -COMMA- denotes ,
T708 965-970 IN denotes while
T709 971-974 DT denotes the
T710 975-981 NN denotes levels
T711 982-984 IN denotes of
T712 985-988 DT denotes the
T713 989-1006 JJ denotes anti-inflammatory
T714 1007-1015 NN denotes cytokine
T715 1016-1021 NN denotes IL-10
T716 1022-1026 VB denotes were
T717 1027-1030 RB denotes not
T718 1031-1039 VB denotes affected
T719 1040-1042 IN denotes by
T720 1043-1046 NN denotes PMA
T721 1047-1050 CC denotes but
T722 1051-1055 VB denotes were
T723 1056-1069 RB denotes significantly
T724 1070-1084 VB denotes down-regulated
T725 1085-1087 IN denotes by
T726 1088-1090 NNP denotes HK
T727 1091-1093 NNP denotes E.
T728 1094-1098 FW denotes coli
T729 1100-1104 NN denotes AP-1
T730 1105-1115 NN denotes activation
T731 1116-1119 VB denotes was
T732 1120-1133 RB denotes significantly
T733 1134-1143 VB denotes increased
T734 1144-1145 CD denotes 2
T735 1146-1147 NN denotes h
T736 1148-1153 IN denotes after
T737 1154-1157 NN denotes PMA
T738 1158-1166 NN denotes exposure
T739 1167-1170 CC denotes and
T740 1171-1180 VB denotes continued
T741 1181-1183 TO denotes to
T742 1184-1192 VB denotes increase
T743 1193-1203 RB denotes thereafter
T744 1205-1207 IN denotes In
T745 1208-1216 NN denotes contrast
T746 1216-1217 -COMMA- denotes ,
T747 1218-1223 NN denotes NF-κB
T748 1224-1233 VB denotes responded
T749 1234-1236 TO denotes to
T750 1237-1240 NN denotes PMA
T751 1241-1249 NN denotes exposure
T752 1250-1252 IN denotes by
T753 1253-1254 DT denotes a
T754 1255-1260 JJ denotes rapid
T755 1261-1274 NN denotes up-regulation
T756 1275-1283 VB denotes followed
T757 1284-1286 IN denotes by
T758 1287-1288 DT denotes a
T759 1289-1299 JJ denotes subsequent
T760 1300-1315 NN denotes down-regulation
T761 1317-1326 VB denotes Increased
T762 1327-1340 JJ denotes intracellular
T763 1341-1345 NN denotes Ca2+
T764 1346-1360 NN denotes concentrations
T765 1361-1370 VB denotes countered
T766 1371-1374 DT denotes the
T767 1375-1390 NN denotes down-regulation
T768 1391-1393 IN denotes of
T769 1394-1399 NN denotes NF-κB
T770 1400-1402 IN denotes by
T771 1403-1406 NN denotes PMA
T772 1406-1407 -COMMA- denotes ,
T773 1408-1413 IN denotes while
T774 1414-1421 JJ denotes similar
T775 1422-1431 NN denotes treatment
T776 1432-1436 IN denotes with
T777 1437-1444 NN denotes calcium
T778 1445-1454 NN denotes ionophore
T779 1455-1463 VB denotes resulted
T780 1464-1466 IN denotes in
T781 1467-1468 DT denotes a
T782 1469-1476 VB denotes reduced
T783 1477-1482 NN denotes NF-κB
T784 1483-1491 NN denotes activity
T785 1492-1501 VB denotes following
T786 1502-1511 NN denotes induction
T787 1512-1516 IN denotes with
T788 1517-1519 NN denotes HK
T789 1520-1522 FW denotes E.
T790 1523-1527 FW denotes coli
T791 1529-1531 IN denotes In
T792 1532-1537 NN denotes order
T793 1538-1540 TO denotes to
T794 1541-1548 JJ denotes further
T795 1549-1554 NN denotes study
T796 1555-1560 NN denotes NF-κB
T797 1561-1571 NN denotes activation
T798 1571-1572 -COMMA- denotes ,
T799 1573-1575 PRP denotes we
T800 1576-1586 VB denotes considered
T801 1587-1590 CD denotes two
T802 1591-1600 JJ denotes up-stream
T803 1601-1611 NN denotes signalling
T804 1612-1620 NN denotes proteins
T805 1620-1621 -COMMA- denotes ,
T806 1622-1625 NN denotes PKC
T807 1626-1629 CC denotes and
T808 1630-1635 NN denotes Bcl10
T809 1637-1655 NN denotes Phosphorylated-PKC
T810 1656-1662 NN denotes levels
T811 1663-1672 VB denotes increased
T812 1673-1675 IN denotes in
T813 1676-1684 NN denotes response
T814 1685-1687 TO denotes to
T815 1688-1691 NN denotes PMA
T816 1692-1695 CC denotes and
T817 1696-1698 NN denotes HK
T818 1699-1701 FW denotes E.
T819 1702-1706 FW denotes coli
T820 1706-1707 -COMMA- denotes ,
T821 1708-1713 IN denotes while
T822 1714-1719 NN denotes Bcl10
T823 1720-1726 NN denotes levels
T824 1727-1740 RB denotes significantly
T825 1741-1750 VB denotes decreased
T826 1751-1760 VB denotes following
T827 1761-1764 NN denotes PMA
T828 1765-1774 NN denotes treatment
T829 1776-1781 VB denotes Using
T830 1782-1784 DT denotes an
T831 1785-1790 NN denotes NF-κB
T832 1791-1801 NN denotes activation
T833 1802-1811 NN denotes inhibitor
T834 1811-1812 -COMMA- denotes ,
T835 1813-1815 PRP denotes we
T836 1816-1824 VB denotes observed
T837 1825-1833 JJ denotes complete
T838 1834-1844 NN denotes inhibition
T839 1845-1847 IN denotes of
T840 1848-1852 NN denotes IL-6
T841 1853-1863 NN denotes expression
T842 1864-1869 IN denotes while
T843 1870-1875 NN denotes CXCL8
T844 1876-1882 NN denotes levels
T845 1883-1887 RB denotes only
T846 1888-1897 VB denotes decreased
T847 1898-1900 IN denotes by
T848 1901-1903 CD denotes 40
T849 1903-1904 NN denotes %
T850 1905-1907 IN denotes at
T851 1908-1911 DT denotes the
T852 1912-1919 JJ denotes highest
T853 1920-1933 NN denotes concentration
T854 1935-1944 NN denotes Treatment
T855 1945-1947 IN denotes of
T856 1948-1954 NN denotes Jurkat
T857 1955-1962 NN denotes T-cells
T858 1963-1967 IN denotes with
T859 1968-1971 NN denotes PMA
T860 1972-1974 IN denotes in
T861 1975-1978 DT denotes the
T862 1979-1987 NN denotes presence
T863 1988-1990 IN denotes of
T864 1991-2004 NN denotes JNK-inhibitor
T865 2005-2015 VB denotes suppressed
T866 2016-2020 CC denotes both
T867 2021-2026 NN denotes CXCL8
T868 2027-2030 CC denotes and
T869 2031-2035 NN denotes IL-6
T870 2036-2041 IN denotes while
T871 2042-2055 NN denotes PKC-inhibitor
T872 2056-2065 RB denotes primarily
T873 2066-2075 VB denotes decreased
T874 2076-2081 NN denotes CXCL8
T875 2082-2092 NN denotes expression
T876 2095-2105 NN denotes Conclusion
T877 2106-2109 DT denotes The
T878 2110-2117 JJ denotes present
T879 2118-2123 NN denotes study
T880 2124-2129 VB denotes shows
T881 2130-2134 IN denotes that
T882 2135-2140 NN denotes NF-κB
T883 2141-2150 VB denotes regulated
T884 2151-2155 NN denotes IL-6
T885 2156-2159 CC denotes but
T886 2160-2163 RB denotes not
T887 2164-2169 NN denotes CXCL8
T888 2171-2175 DT denotes This
T889 2176-2183 JJ denotes complex
T890 2184-2194 NN denotes regulation
T891 2195-2197 IN denotes of
T892 2198-2203 NN denotes CXCL8
T893 2204-2212 VB denotes suggests
T894 2213-2217 IN denotes that
T895 2218-2223 EX denotes there
T896 2224-2226 VB denotes is
T897 2227-2228 DT denotes a
T898 2229-2233 NN denotes need
T899 2234-2236 TO denotes to
T900 2237-2244 RB denotes further
T901 2245-2253 VB denotes evaluate
T902 2254-2257 DT denotes the
T903 2258-2268 NN denotes signalling
T904 2269-2277 NN denotes pathways
T905 2278-2280 IN denotes in
T906 2281-2286 NN denotes order
T907 2287-2289 TO denotes to
T908 2290-2297 VB denotes develop
T909 2298-2301 JJ denotes new
T910 2302-2311 NN denotes treatment
T911 2312-2315 IN denotes for
T912 2316-2324 NN denotes diseases
T913 2325-2329 IN denotes with
T914 2330-2338 JJ denotes elevated
T915 2339-2344 NN denotes CXCL8
T916 2345-2351 NN denotes levels
T917 2351-2352 -COMMA- denotes ,
T918 2353-2357 JJ denotes such
T919 2358-2360 IN denotes as
T920 2361-2365 NN denotes AIDS
T921 2366-2369 CC denotes and
T922 2370-2380 JJ denotes autoimmune
T923 2381-2389 NN denotes diseases
T3418 590-600 NN denotes regulation
T3419 601-603 IN denotes of
T3420 604-608 NN denotes AP-1
T3421 609-612 CC denotes and
R437 T551 T550 arg1Of protein,Activator
R438 T551 T552 arg1Of protein,(
R439 T551 T555 arg1Of protein,-1
R440 T551 T556 arg1Of protein,and
R441 T553 T552 arg2Of AP,(
R442 T554 T552 arg3Of ),(
R443 T556 T564 arg1Of and,control
R444 T560 T559 arg2Of NF,(
R445 T561 T559 arg3Of ),(
R446 T562 T556 arg2Of -κB,and
R447 T562 T557 arg1Of -κB,nuclear
R448 T562 T558 arg1Of -κB,factor
R449 T562 T559 arg1Of -κB,(
R450 T564 T563 arg1Of control,largely
R451 T564 T567 arg1Of control,","
R452 T564 T568 arg1Of control,following
R453 T566 T564 arg2Of activation,control
R454 T566 T565 arg1Of activation,T-cell
R455 T569 T568 arg2Of binding,following
R456 T569 T570 arg1Of binding,of
R457 T569 T573 arg1Of binding,to
R458 T572 T570 arg2Of antigens,of
R459 T572 T571 arg1Of antigens,foreign
R460 T576 T573 arg2Of receptor,to
R461 T576 T574 arg1Of receptor,the
R462 T576 T575 arg1Of receptor,T-cell
R463 T576 T577 arg1Of receptor,leading
R464 T577 T578 arg1Of leading,to
R465 T580 T578 arg2Of secretion,to
R466 T580 T579 arg1Of secretion,cytokine
R467 T582 T581 arg1Of levels,Elevated
R468 T582 T583 arg1Of levels,of
R469 T582 T595 arg1Of levels,are
R470 T582 T596 arg2Of levels,associated
R471 T585 T586 arg1Of cytokines,and
R472 T586 T583 arg2Of and,of
R473 T586 T584 arg1Of and,pro-inflammatory
R474 T586 T589 arg1Of and,as
R475 T587 T586 arg2Of chemokines,and
R476 T589 T588 arg1Of as,such
R477 T590 T591 arg1Of TNF,","
R478 T591 T593 arg1Of ",",and
R479 T592 T591 arg2Of IL-6,","
R480 T593 T589 arg2Of and,as
R481 T594 T593 arg2Of CXCL8,and
R482 T596 T595 arg2Of associated,are
R483 T596 T597 arg1Of associated,with
R484 T600 T597 arg2Of diseases,with
R485 T600 T598 arg1Of diseases,several
R486 T600 T599 arg1Of diseases,human
R487 T600 T601 arg1Of diseases,including
R488 T603 T602 arg1Of fibrosis,cystic
R489 T603 T604 arg1Of fibrosis,","
R490 T604 T607 arg1Of ",",and
R491 T606 T604 arg2Of fibrosis,","
R492 T606 T605 arg1Of fibrosis,pulmonary
R493 T607 T601 arg2Of and,including
R494 T608 T607 arg2Of AIDS,and
R495 T610 T609 arg1Of aim,The
R496 T610 T611 arg1Of aim,of
R497 T610 T614 arg1Of aim,was
R498 T613 T611 arg2Of study,of
R499 T613 T612 arg1Of study,this
R500 T616 T614 arg2Of investigate,was
R501 T616 T615 arg1Of investigate,to
R502 T618 T616 arg2Of role,investigate
R503 T618 T617 arg1Of role,the
R504 T618 T619 arg1Of role,of
R505 T618 T627 arg1Of role,","
R506 T618 T628 arg1Of role,in
R507 T622 T619 arg2Of factors,of
R508 T622 T620 arg1Of factors,the
R509 T622 T621 arg1Of factors,transcription
R510 T622 T623 arg1Of factors,","
R511 T624 T625 arg1Of AP-1,and
R512 T625 T623 arg2Of and,","
R513 T626 T625 arg2Of NF-κB,and
R514 T629 T630 arg1Of IL-6,and
R515 T631 T630 arg2Of CXCL8,and
R516 T632 T628 arg2Of regulation,in
R517 T632 T629 arg1Of regulation,IL-6
R518 T632 T631 arg1Of regulation,CXCL8
R519 T632 T633 arg1Of regulation,in
R520 T635 T633 arg2Of T-cells,in
R521 T635 T634 arg1Of T-cells,Jurkat
R522 T639 T637 arg1Of acetate,Phorbol
R523 T639 T638 arg1Of acetate,myristate
R524 T639 T640 arg1Of acetate,(
R525 T641 T640 arg2Of PMA,(
R526 T642 T640 arg3Of ),(
R527 T643 T639 arg1Of exposure,acetate
R528 T643 T644 arg1Of exposure,resulted
R529 T644 T645 arg1Of resulted,in
R530 T644 T655 arg1Of resulted,","
R531 T644 T656 arg1Of resulted,however
R532 T644 T657 arg1Of resulted,","
R533 T647 T645 arg2Of up-regulation,in
R534 T647 T646 arg1Of up-regulation,an
R535 T647 T648 arg1Of up-regulation,of
R536 T649 T650 arg1Of AP-1,and
R537 T650 T648 arg2Of and,of
R538 T650 T652 arg1Of and,of
R539 T651 T650 arg2Of down-regulation,and
R540 T654 T652 arg2Of activity,of
R541 T654 T653 arg1Of activity,NF-κB
R542 T657 T676 arg1Of ",",without
R543 T658 T659 arg1Of exposure,to
R544 T658 T668 arg1Of exposure,resulted
R545 T660 T661 arg2Of heat,killed
R546 T661 T662 arg1Of killed,(
R547 T663 T662 arg2Of HK,(
R548 T664 T662 arg3Of ),(
R549 T667 T659 arg2Of MG1655,to
R550 T667 T660 arg1Of MG1655,heat
R551 T667 T665 arg1Of MG1655,Escherichia.
R552 T667 T666 arg1Of MG1655,coli
R553 T668 T657 arg2Of resulted,","
R554 T668 T669 arg1Of resulted,in
R555 T672 T669 arg2Of increase,in
R556 T672 T670 arg1Of increase,a
R557 T672 T671 arg1Of increase,dose-dependent
R558 T672 T673 arg1Of increase,in
R559 T675 T673 arg2Of activity,in
R560 T675 T674 arg1Of activity,NF-κB
R561 T677 T676 arg2Of affecting,without
R562 T678 T677 arg2Of AP-1,affecting
R563 T681 T679 arg1Of profile,The
R564 T681 T680 arg1Of profile,cytokine
R565 T681 T682 arg1Of profile,revealed
R566 T682 T698 arg1Of revealed,following
R567 T682 T707 arg1Of revealed,","
R568 T682 T708 arg1Of revealed,while
R569 T684 T683 arg1Of up-regulation,an
R570 T684 T685 arg1Of up-regulation,of
R571 T684 T689 arg1Of up-regulation,and
R572 T688 T685 arg2Of CXCL8,of
R573 T688 T686 arg1Of CXCL8,the
R574 T688 T687 arg1Of CXCL8,chemokine
R575 T689 T682 arg2Of and,revealed
R576 T692 T690 arg1Of cytokines,the
R577 T692 T691 arg1Of cytokines,pro-inflammatory
R578 T693 T694 arg1Of TNF,","
R579 T694 T696 arg1Of ",",and
R580 T695 T694 arg2Of IL-2,","
R581 T696 T689 arg2Of and,and
R582 T696 T692 arg1Of and,cytokines
R583 T697 T696 arg2Of IL-6,and
R584 T699 T698 arg2Of treatment,following
R585 T699 T700 arg1Of treatment,with
R586 T702 T703 arg1Of PMA,and
R587 T703 T700 arg2Of and,with
R588 T703 T701 arg1Of and,both
R589 T703 T706 arg1Of and,coli
R590 T704 T703 arg2Of HK,and
R591 T706 T705 arg1Of coli,E.
R592 T710 T709 arg1Of levels,the
R593 T710 T711 arg1Of levels,of
R594 T710 T716 arg1Of levels,were
R595 T710 T718 arg2Of levels,affected
R596 T710 T722 arg1Of levels,were
R597 T710 T724 arg2Of levels,down-regulated
R598 T715 T711 arg2Of IL-10,of
R599 T715 T712 arg1Of IL-10,the
R600 T715 T713 arg1Of IL-10,anti-inflammatory
R601 T715 T714 arg1Of IL-10,cytokine
R602 T718 T716 arg2Of affected,were
R603 T718 T717 arg1Of affected,not
R604 T718 T721 arg1Of affected,but
R605 T720 T718 arg1Of PMA,affected
R606 T720 T719 arg2Of PMA,by
R607 T721 T708 arg2Of but,while
R608 T724 T721 arg2Of down-regulated,but
R609 T724 T722 arg2Of down-regulated,were
R610 T724 T723 arg1Of down-regulated,significantly
R611 T727 T724 arg1Of E.,down-regulated
R612 T727 T725 arg2Of E.,by
R613 T727 T726 arg1Of E.,HK
R614 T727 T728 arg1Of E.,coli
R615 T730 T729 arg1Of activation,AP-1
R616 T730 T731 arg1Of activation,was
R617 T730 T733 arg2Of activation,increased
R618 T730 T740 arg1Of activation,continued
R619 T730 T742 arg1Of activation,increase
R620 T733 T731 arg2Of increased,was
R621 T733 T732 arg1Of increased,significantly
R622 T733 T736 arg1Of increased,after
R623 T733 T739 arg1Of increased,and
R624 T735 T734 arg1Of h,2
R625 T736 T735 arg1Of after,h
R626 T738 T736 arg2Of exposure,after
R627 T738 T737 arg1Of exposure,PMA
R628 T740 T739 arg2Of continued,and
R629 T742 T740 arg2Of increase,continued
R630 T742 T741 arg1Of increase,to
R631 T742 T743 arg1Of increase,thereafter
R632 T745 T744 arg2Of contrast,In
R633 T747 T748 arg1Of NF-κB,responded
R634 T748 T744 arg1Of responded,In
R635 T748 T746 arg1Of responded,","
R636 T748 T749 arg1Of responded,to
R637 T748 T752 arg1Of responded,by
R638 T751 T749 arg2Of exposure,to
R639 T751 T750 arg1Of exposure,PMA
R640 T755 T752 arg2Of up-regulation,by
R641 T755 T753 arg1Of up-regulation,a
R642 T755 T754 arg1Of up-regulation,rapid
R643 T755 T756 arg2Of up-regulation,followed
R644 T760 T756 arg1Of down-regulation,followed
R645 T760 T757 arg2Of down-regulation,by
R646 T760 T758 arg1Of down-regulation,a
R647 T760 T759 arg1Of down-regulation,subsequent
R648 T764 T761 arg2Of concentrations,Increased
R649 T764 T762 arg1Of concentrations,intracellular
R650 T764 T763 arg1Of concentrations,Ca2+
R651 T764 T765 arg1Of concentrations,countered
R652 T765 T772 arg1Of countered,","
R653 T765 T773 arg1Of countered,while
R654 T767 T765 arg2Of down-regulation,countered
R655 T767 T766 arg1Of down-regulation,the
R656 T767 T768 arg1Of down-regulation,of
R657 T767 T770 arg1Of down-regulation,by
R658 T769 T768 arg2Of NF-κB,of
R659 T771 T770 arg2Of PMA,by
R660 T775 T774 arg1Of treatment,similar
R661 T775 T776 arg1Of treatment,with
R662 T775 T779 arg1Of treatment,resulted
R663 T778 T776 arg2Of ionophore,with
R664 T778 T777 arg1Of ionophore,calcium
R665 T779 T773 arg2Of resulted,while
R666 T779 T780 arg1Of resulted,in
R667 T784 T780 arg2Of activity,in
R668 T784 T781 arg1Of activity,a
R669 T784 T782 arg2Of activity,reduced
R670 T784 T783 arg1Of activity,NF-κB
R671 T784 T785 arg1Of activity,following
R672 T786 T785 arg2Of induction,following
R673 T786 T787 arg1Of induction,with
R674 T790 T787 arg2Of coli,with
R675 T790 T788 arg1Of coli,HK
R676 T790 T789 arg1Of coli,E.
R677 T791 T793 arg1Of In,to
R678 T792 T791 arg2Of order,In
R679 T797 T791 arg3Of activation,In
R680 T797 T794 arg1Of activation,further
R681 T797 T795 arg1Of activation,study
R682 T797 T796 arg1Of activation,NF-κB
R683 T799 T800 arg1Of we,considered
R684 T800 T791 arg1Of considered,In
R685 T800 T798 arg1Of considered,","
R686 T804 T800 arg2Of proteins,considered
R687 T804 T801 arg1Of proteins,two
R688 T804 T802 arg1Of proteins,up-stream
R689 T804 T803 arg1Of proteins,signalling
R690 T804 T805 arg1Of proteins,","
R691 T806 T807 arg1Of PKC,and
R692 T807 T805 arg2Of and,","
R693 T808 T807 arg2Of Bcl10,and
R694 T810 T809 arg1Of levels,Phosphorylated-PKC
R695 T810 T811 arg1Of levels,increased
R696 T811 T812 arg1Of increased,in
R697 T811 T820 arg1Of increased,","
R698 T811 T821 arg1Of increased,while
R699 T813 T812 arg2Of response,in
R700 T813 T814 arg1Of response,to
R701 T815 T816 arg1Of PMA,and
R702 T816 T814 arg2Of and,to
R703 T817 T816 arg2Of HK,and
R704 T819 T812 arg3Of coli,in
R705 T819 T818 arg1Of coli,E.
R706 T823 T822 arg1Of levels,Bcl10
R707 T823 T825 arg1Of levels,decreased
R708 T825 T821 arg2Of decreased,while
R709 T825 T824 arg1Of decreased,significantly
R710 T825 T826 arg1Of decreased,following
R711 T828 T826 arg2Of treatment,following
R712 T828 T827 arg1Of treatment,PMA
R713 T833 T829 arg2Of inhibitor,Using
R714 T833 T830 arg1Of inhibitor,an
R715 T833 T831 arg1Of inhibitor,NF-κB
R716 T833 T832 arg1Of inhibitor,activation
R717 T835 T829 arg1Of we,Using
R718 T835 T836 arg1Of we,observed
R719 T836 T829 modOf observed,Using
R720 T836 T834 arg1Of observed,","
R721 T836 T842 arg1Of observed,while
R722 T838 T836 arg2Of inhibition,observed
R723 T838 T837 arg1Of inhibition,complete
R724 T838 T839 arg1Of inhibition,of
R725 T841 T839 arg2Of expression,of
R726 T841 T840 arg1Of expression,IL-6
R727 T844 T843 arg1Of levels,CXCL8
R728 T844 T846 arg1Of levels,decreased
R729 T846 T842 arg2Of decreased,while
R730 T846 T845 arg1Of decreased,only
R731 T846 T847 arg1Of decreased,by
R732 T846 T850 arg1Of decreased,at
R733 T849 T847 arg2Of %,by
R734 T849 T848 arg1Of %,40
R735 T853 T850 arg2Of concentration,at
R736 T853 T851 arg1Of concentration,the
R737 T853 T852 arg1Of concentration,highest
R738 T854 T855 arg1Of Treatment,of
R739 T854 T858 arg1Of Treatment,with
R740 T854 T860 arg1Of Treatment,in
R741 T854 T865 arg1Of Treatment,suppressed
R742 T857 T855 arg2Of T-cells,of
R743 T857 T856 arg1Of T-cells,Jurkat
R744 T859 T858 arg2Of PMA,with
R745 T862 T860 arg2Of presence,in
R746 T862 T861 arg1Of presence,the
R747 T862 T863 arg1Of presence,of
R748 T864 T863 arg2Of JNK-inhibitor,of
R749 T865 T870 arg1Of suppressed,while
R750 T867 T868 arg1Of CXCL8,and
R751 T868 T865 arg2Of and,suppressed
R752 T868 T866 arg1Of and,both
R753 T869 T868 arg2Of IL-6,and
R754 T871 T873 arg1Of PKC-inhibitor,decreased
R755 T873 T870 arg2Of decreased,while
R756 T873 T872 arg1Of decreased,primarily
R757 T875 T873 arg2Of expression,decreased
R758 T875 T874 arg1Of expression,CXCL8
R759 T879 T877 arg1Of study,The
R760 T879 T878 arg1Of study,present
R761 T879 T880 arg1Of study,shows
R762 T882 T883 arg1Of NF-κB,regulated
R763 T883 T880 arg2Of regulated,shows
R764 T883 T881 arg1Of regulated,that
R765 T884 T885 arg1Of IL-6,but
R766 T885 T883 arg2Of but,regulated
R767 T885 T886 arg1Of but,not
R768 T887 T885 arg2Of CXCL8,but
R769 T890 T888 arg1Of regulation,This
R770 T890 T889 arg1Of regulation,complex
R771 T890 T891 arg1Of regulation,of
R772 T890 T893 arg1Of regulation,suggests
R773 T892 T891 arg2Of CXCL8,of
R774 T895 T896 arg1Of there,is
R775 T895 T908 arg1Of there,develop
R776 T896 T893 arg2Of is,suggests
R777 T896 T894 arg1Of is,that
R778 T896 T905 arg1Of is,in
R779 T898 T896 arg2Of need,is
R780 T898 T897 arg1Of need,a
R781 T898 T899 modOf need,to
R782 T901 T899 arg1Of evaluate,to
R783 T901 T900 arg1Of evaluate,further
R784 T904 T901 arg2Of pathways,evaluate
R785 T904 T902 arg1Of pathways,the
R786 T904 T903 arg1Of pathways,signalling
R787 T906 T905 arg2Of order,in
R788 T908 T905 arg3Of develop,in
R789 T908 T907 arg1Of develop,to
R790 T910 T908 arg2Of treatment,develop
R791 T910 T909 arg1Of treatment,new
R792 T910 T911 arg1Of treatment,for
R793 T912 T911 arg2Of diseases,for
R794 T912 T913 arg1Of diseases,with
R795 T916 T913 arg2Of levels,with
R796 T916 T914 arg1Of levels,elevated
R797 T916 T915 arg1Of levels,CXCL8
R798 T916 T917 arg1Of levels,","
R799 T916 T919 arg1Of levels,as
R800 T919 T918 arg1Of as,such
R801 T920 T921 arg1Of AIDS,and
R802 T921 T919 arg2Of and,as
R803 T923 T921 arg2Of diseases,and
R804 T923 T922 arg1Of diseases,autoimmune
R2763 T3418 T3419 arg1Of regulation,of
R2764 T3420 T3421 arg1Of AP-1,and
R2765 T3421 T3419 arg2Of and,of

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T166 96-97 , denotes ,
T167 98-107 VBG denotes following
T168 108-115 JJ denotes binding
T169 116-118 IN denotes of
T170 119-126 JJ denotes foreign
T171 127-135 NNS denotes antigens
T172 136-138 TO denotes to
T173 139-142 DT denotes the
T174 143-149 NN denotes T-cell
T175 150-158 NN denotes receptor
T176 159-166 VBG denotes leading
T177 167-169 TO denotes to
T178 170-178 VB denotes cytokine
T179 179-188 NN denotes secretion
T180 188-189 . denotes .
T181 190-198 JJ denotes Elevated
T182 199-205 NNS denotes levels
T183 206-208 IN denotes of
T184 209-225 JJ denotes pro-inflammatory
T185 226-235 NNS denotes cytokines
T186 236-239 CC denotes and
T187 240-250 NNS denotes chemokines
T188 251-255 JJ denotes such
T189 256-258 IN denotes as
T190 259-262 NNP denotes TNF
T191 262-263 , denotes ,
T192 264-268 NNP denotes IL-6
T193 269-272 CC denotes and
T194 273-278 NNP denotes CXCL8
T195 279-282 VBP denotes are
T196 283-293 VBN denotes associated
T197 294-298 IN denotes with
T198 299-306 JJ denotes several
T199 307-312 JJ denotes human
T200 313-321 NNS denotes diseases
T201 322-331 VBG denotes including
T202 332-338 JJ denotes cystic
T203 339-347 NN denotes fibrosis
T204 347-348 , denotes ,
T205 349-358 JJ denotes pulmonary
T206 359-367 NN denotes fibrosis
T207 368-371 CC denotes and
T208 372-376 NNP denotes AIDS
T209 376-377 . denotes .
T210 378-381 DT denotes The
T211 382-385 NN denotes aim
T212 386-388 IN denotes of
T213 389-393 DT denotes this
T214 394-399 NN denotes study
T215 400-403 VBD denotes was
T216 404-406 TO denotes to
T217 407-418 VB denotes investigate
T218 419-422 DT denotes the
T219 423-427 NN denotes role
T220 428-430 IN denotes of
T221 431-434 DT denotes the
T222 435-448 NN denotes transcription
T223 449-456 NNS denotes factors
T224 456-457 , denotes ,
T225 458-462 NNP denotes AP-1
T226 463-466 CC denotes and
T227 467-472 NNP denotes NF-κB
T228 472-473 , denotes ,
T229 474-476 IN denotes in
T230 477-481 NNP denotes IL-6
T231 482-485 CC denotes and
T232 486-491 NNP denotes CXCL8
T233 492-502 NN denotes regulation
T234 503-505 IN denotes in
T235 506-512 NNP denotes Jurkat
T236 513-520 NNS denotes T-cells
T237 520-521 . denotes .
T238 523-530 NNS denotes Results
T239 531-538 NNP denotes Phorbol
T240 539-548 NN denotes myristate
T241 549-556 NN denotes acetate
T242 557-558 -LRB- denotes (
T243 558-561 NNP denotes PMA
T244 561-562 -RRB- denotes )
T245 563-571 NN denotes exposure
T246 572-580 VBD denotes resulted
T247 581-583 IN denotes in
T248 584-586 DT denotes an
T249 587-600 NN denotes up-regulation
T250 601-603 IN denotes of
T251 604-608 NN denotes AP-1
T252 609-612 CC denotes and
T253 613-628 NN denotes down-regulation
T254 629-631 IN denotes of
T255 632-637 JJ denotes NF-κB
T256 638-646 NN denotes activity
T257 646-647 , denotes ,
T258 648-655 RB denotes however
T259 655-656 , denotes ,
T260 657-665 NN denotes exposure
T261 666-668 TO denotes to
T262 669-673 VB denotes heat
T263 674-680 VBN denotes killed
T264 681-682 -LRB- denotes (
T265 682-684 NNP denotes HK
T266 684-685 -RRB- denotes )
T267 686-697 NNP denotes Escherichia
T268 697-698 . denotes .
T269 699-703 NNS denotes coli
T270 704-710 NNS denotes MG1655
T271 711-719 VBD denotes resulted
T272 720-722 IN denotes in
T273 723-724 DT denotes a
T274 725-739 JJ denotes dose-dependent
T275 740-748 NN denotes increase
T276 749-751 IN denotes in
T277 752-757 JJ denotes NF-κB
T278 758-766 NN denotes activity
T279 767-774 IN denotes without
T280 775-784 VBG denotes affecting
T281 785-789 NN denotes AP-1
T282 789-790 . denotes .
T283 791-794 DT denotes The
T284 795-803 NN denotes cytokine
T285 804-811 NN denotes profile
T286 812-820 VBD denotes revealed
T287 821-823 DT denotes an
T288 824-837 NN denotes up-regulation
T289 838-840 IN denotes of
T290 841-844 DT denotes the
T291 845-854 NN denotes chemokine
T292 855-860 NNP denotes CXCL8
T293 861-864 CC denotes and
T294 865-868 DT denotes the
T295 869-885 JJ denotes pro-inflammatory
T296 886-895 NNS denotes cytokines
T297 896-899 NNP denotes TNF
T298 899-900 , denotes ,
T299 901-905 NNP denotes IL-2
T300 906-909 CC denotes and
T301 910-914 NNP denotes IL-6
T302 915-924 VBG denotes following
T303 925-934 NN denotes treatment
T304 935-939 IN denotes with
T305 940-944 DT denotes both
T306 945-948 NNP denotes PMA
T307 949-952 CC denotes and
T308 953-955 NNP denotes HK
T309 956-958 NNP denotes E.
T310 959-963 NNS denotes coli
T311 963-964 , denotes ,
T312 965-970 IN denotes while
T313 971-974 DT denotes the
T314 975-981 NNS denotes levels
T315 982-984 IN denotes of
T316 985-988 DT denotes the
T317 989-1006 JJ denotes anti-inflammatory
T318 1007-1015 NN denotes cytokine
T319 1016-1021 NN denotes IL-10
T320 1022-1026 VBD denotes were
T321 1027-1030 RB denotes not
T322 1031-1039 VBN denotes affected
T323 1040-1042 IN denotes by
T324 1043-1046 NNP denotes PMA
T325 1047-1050 CC denotes but
T326 1051-1055 VBD denotes were
T327 1056-1069 RB denotes significantly
T328 1070-1084 VBN denotes down-regulated
T329 1085-1087 IN denotes by
T330 1088-1090 NNP denotes HK
T331 1091-1093 NNP denotes E.
T332 1094-1098 NNS denotes coli
T333 1098-1099 . denotes .
T334 1100-1104 CD denotes AP-1
T335 1105-1115 NN denotes activation
T336 1116-1119 VBD denotes was
T337 1120-1133 RB denotes significantly
T338 1134-1143 VBN denotes increased
T339 1144-1145 CD denotes 2
T340 1146-1147 NN denotes h
T341 1148-1153 IN denotes after
T342 1154-1157 NNP denotes PMA
T343 1158-1166 NN denotes exposure
T344 1167-1170 CC denotes and
T345 1171-1180 VBD denotes continued
T346 1181-1183 TO denotes to
T347 1184-1192 VB denotes increase
T348 1193-1203 RB denotes thereafter
T349 1203-1204 . denotes .
T350 1205-1207 IN denotes In
T351 1208-1216 NN denotes contrast
T352 1216-1217 , denotes ,
T353 1218-1223 NNP denotes NF-κB
T354 1224-1233 VBD denotes responded
T355 1234-1236 TO denotes to
T356 1237-1240 NNP denotes PMA
T357 1241-1249 NN denotes exposure
T358 1400-1402 IN denotes by
T359 1250-1252 IN denotes by
T360 1253-1254 DT denotes a
T361 1255-1260 JJ denotes rapid
T362 1261-1274 NN denotes up-regulation
T363 1275-1283 VBN denotes followed
T364 1284-1286 IN denotes by
T365 1287-1288 DT denotes a
T366 1289-1299 JJ denotes subsequent
T367 1300-1315 NN denotes down-regulation
T368 1315-1316 . denotes .
T369 1317-1326 VBN denotes Increased
T370 1327-1340 JJ denotes intracellular
T371 1341-1344 NNP denotes Ca2
T372 1344-1345 NN denotes +
T373 1346-1360 NNS denotes concentrations
T374 1361-1370 VBD denotes countered
T375 1371-1374 DT denotes the
T376 1375-1390 NN denotes down-regulation
T377 1391-1393 IN denotes of
T378 1394-1399 NN denotes NF-κB
T379 1403-1406 NNP denotes PMA
T380 1406-1407 , denotes ,
T381 1408-1413 IN denotes while
T382 1414-1421 JJ denotes similar
T383 1422-1431 NN denotes treatment
T384 1432-1436 IN denotes with
T385 1437-1444 NN denotes calcium
T386 1445-1454 NN denotes ionophore
T387 1455-1463 VBD denotes resulted
T388 1464-1466 IN denotes in
T389 1467-1468 DT denotes a
T390 1469-1476 VBN denotes reduced
T391 1477-1482 NN denotes NF-κB
T392 1483-1491 NN denotes activity
T393 1492-1501 VBG denotes following
T394 1502-1511 NN denotes induction
T395 1512-1516 IN denotes with
T396 1517-1519 NNP denotes HK
T397 1520-1522 NNP denotes E.
T398 1523-1527 NNS denotes coli
T399 1527-1528 . denotes .
T400 1529-1531 IN denotes In
T401 1532-1537 NN denotes order
T402 1538-1540 TO denotes to
T403 1541-1548 JJ denotes further
T404 1549-1554 NN denotes study
T405 1555-1560 NN denotes NF-κB
T406 1561-1571 NN denotes activation
T407 1571-1572 , denotes ,
T408 1573-1575 PRP denotes we
T409 1576-1586 VBD denotes considered
T410 1587-1590 CD denotes two
T411 1591-1600 JJ denotes up-stream
T412 1601-1611 JJ denotes signalling
T413 1612-1620 NNS denotes proteins
T414 1620-1621 , denotes ,
T415 1622-1625 NNP denotes PKC
T416 1626-1629 CC denotes and
T417 1630-1635 NNP denotes Bcl10
T418 1635-1636 . denotes .
T419 1637-1655 NN denotes Phosphorylated-PKC
T420 1656-1662 NNS denotes levels
T421 1663-1672 VBN denotes increased
T422 1673-1675 IN denotes in
T423 1676-1684 NN denotes response
T424 1685-1687 TO denotes to
T425 1688-1691 NNP denotes PMA
T426 1692-1695 CC denotes and
T427 1696-1698 NNP denotes HK
T428 1699-1701 NNP denotes E.
T429 1702-1706 NNS denotes coli
T430 1706-1707 , denotes ,
T431 1708-1713 IN denotes while
T432 1714-1719 JJ denotes Bcl10
T433 1720-1726 NNS denotes levels
T434 1727-1740 RB denotes significantly
T435 1741-1750 VBD denotes decreased
T436 1751-1760 VBG denotes following
T437 1761-1764 NNP denotes PMA
T438 1765-1774 NN denotes treatment
T439 1774-1775 . denotes .
T440 1776-1781 VBG denotes Using
T441 1782-1784 DT denotes an
T442 1785-1790 JJ denotes NF-κB
T443 1791-1801 NN denotes activation
T444 1802-1811 NN denotes inhibitor
T445 1811-1812 , denotes ,
T446 1813-1815 PRP denotes we
T447 1816-1824 VBD denotes observed
T448 1825-1833 JJ denotes complete
T449 1834-1844 NN denotes inhibition
T450 1845-1847 IN denotes of
T451 1848-1852 NN denotes IL-6
T452 1853-1863 NN denotes expression
T453 1864-1869 IN denotes while
T455 1876-1882 NNS denotes levels
T456 1883-1887 RB denotes only
T457 1888-1897 VBN denotes decreased
T458 1898-1900 IN denotes by
T459 1901-1903 CD denotes 40
T460 1903-1904 NN denotes %
T461 1905-1907 IN denotes at
T462 1908-1911 DT denotes the
T463 1912-1919 JJS denotes highest
T464 1920-1933 NN denotes concentration
T465 1933-1934 . denotes .
T466 1935-1944 NNP denotes Treatment
T467 1945-1947 IN denotes of
T468 1948-1954 NNP denotes Jurkat
T469 1955-1962 NNS denotes T-cells
T470 1963-1967 IN denotes with
T471 1968-1971 NNP denotes PMA
T472 1972-1974 IN denotes in
T473 1975-1978 DT denotes the
T474 1979-1987 NN denotes presence
T475 1988-1990 IN denotes of
T476 1991-2004 JJ denotes JNK-inhibitor
T477 2005-2015 VBN denotes suppressed
T478 2016-2020 DT denotes both
T479 2021-2026 NNP denotes CXCL8
T480 2027-2030 CC denotes and
T481 2031-2035 NNP denotes IL-6
T482 2036-2041 IN denotes while
T483 2042-2055 NNP denotes PKC-inhibitor
T484 2056-2065 RB denotes primarily
T485 2066-2075 VBD denotes decreased
T486 2076-2081 CD denotes CXCL8
T487 2082-2092 NN denotes expression
T488 2092-2093 . denotes .
T489 2095-2105 NN denotes Conclusion
T490 2106-2109 DT denotes The
T491 2110-2117 JJ denotes present
T492 2118-2123 NN denotes study
T493 2124-2129 VBZ denotes shows
T494 2130-2134 IN denotes that
T495 2135-2140 JJ denotes NF-κB
T496 2141-2150 JJ denotes regulated
T497 2151-2155 NN denotes IL-6
T498 2156-2159 CC denotes but
T499 2160-2163 RB denotes not
T500 2164-2169 NNP denotes CXCL8
T501 2169-2170 . denotes .
T502 2171-2175 DT denotes This
T503 2176-2183 JJ denotes complex
T504 2184-2194 NN denotes regulation
T505 2195-2197 IN denotes of
T506 2198-2203 CD denotes CXCL8
T507 2204-2212 VBZ denotes suggests
T508 2213-2217 IN denotes that
T509 2218-2223 EX denotes there
T510 2224-2226 VBZ denotes is
T511 2227-2228 DT denotes a
T512 2229-2233 NN denotes need
T513 2234-2236 TO denotes to
T514 2237-2244 RBR denotes further
T515 2245-2253 VB denotes evaluate
T516 2254-2257 DT denotes the
T517 2258-2268 JJ denotes signalling
T518 2269-2277 NNS denotes pathways
T519 2278-2280 IN denotes in
T520 2281-2286 NN denotes order
T521 2287-2289 TO denotes to
T522 2290-2297 VB denotes develop
T523 2298-2301 JJ denotes new
T524 2302-2311 NN denotes treatment
T525 2312-2315 IN denotes for
T526 2316-2324 NNS denotes diseases
T527 2325-2329 IN denotes with
T528 2330-2338 JJ denotes elevated
T529 2339-2344 NNP denotes CXCL8
T530 2345-2351 NNS denotes levels
T531 2351-2352 , denotes ,
T532 2353-2357 JJ denotes such
T533 2358-2360 IN denotes as
T534 2361-2365 NNP denotes AIDS
T535 2366-2369 CC denotes and
T536 2370-2380 JJ denotes autoimmune
T537 2381-2389 NNS denotes diseases
T538 2389-2390 . denotes .
T3064 590-600 NN denotes regulation
T3065 601-603 IN denotes of
T3066 604-608 NNP denotes AP-1
T3067 609-612 CC denotes and
T147 0-10 NNP denotes Background
T148 11-20 NNP denotes Activator
T149 21-28 NN denotes protein
T150 29-30 -LRB- denotes (
T151 30-32 NNP denotes AP
T152 32-33 -RRB- denotes )
T153 33-35 CD denotes -1
T154 36-39 CC denotes and
T155 40-47 JJ denotes nuclear
T156 48-54 NN denotes factor
T157 55-56 -LRB- denotes (
T158 56-58 NNP denotes NF
T159 58-59 -RRB- denotes )
T160 59-60 : denotes -
T161 60-62 NN denotes κB
T162 63-70 RB denotes largely
T163 71-78 JJ denotes control
T164 79-85 NNP denotes T-cell
T165 86-96 NN denotes activation
T454 1870-1875 NNP denotes CXCL8
R58 T168 T167 pobj binding,following
R59 T169 T168 prep of,binding
R60 T170 T171 amod foreign,antigens
R61 T171 T169 pobj antigens,of
R62 T172 T168 prep to,binding
R63 T173 T175 det the,receptor
R56 T166 T165 punct ",",activation
R64 T174 T175 compound T-cell,receptor
R65 T175 T172 pobj receptor,to
R66 T176 T175 acl leading,receptor
R67 T177 T176 prep to,leading
R68 T178 T179 amod cytokine,secretion
R69 T179 T177 pobj secretion,to
R71 T181 T182 amod Elevated,levels
R72 T182 T196 nsubjpass levels,associated
R73 T183 T182 prep of,levels
R74 T184 T185 amod pro-inflammatory,cytokines
R75 T185 T183 pobj cytokines,of
R76 T186 T185 cc and,cytokines
R77 T187 T185 conj chemokines,cytokines
R78 T188 T189 amod such,as
R79 T189 T187 prep as,chemokines
R80 T190 T189 pobj TNF,as
R81 T191 T190 punct ",",TNF
R82 T192 T190 conj IL-6,TNF
R83 T193 T192 cc and,IL-6
R84 T194 T192 conj CXCL8,IL-6
R85 T195 T196 auxpass are,associated
R86 T196 T196 ROOT associated,associated
R87 T197 T196 prep with,associated
R88 T198 T200 amod several,diseases
R89 T199 T200 amod human,diseases
R90 T200 T197 pobj diseases,with
R91 T201 T200 prep including,diseases
R92 T202 T203 amod cystic,fibrosis
R93 T203 T201 pobj fibrosis,including
R94 T204 T203 punct ",",fibrosis
R95 T205 T206 amod pulmonary,fibrosis
R96 T206 T203 conj fibrosis,fibrosis
R97 T207 T206 cc and,fibrosis
R98 T208 T206 conj AIDS,fibrosis
R99 T209 T196 punct .,associated
R100 T210 T211 det The,aim
R101 T211 T215 nsubj aim,was
R102 T212 T211 prep of,aim
R103 T213 T214 det this,study
R104 T214 T212 pobj study,of
R105 T215 T215 ROOT was,was
R106 T216 T217 aux to,investigate
R107 T217 T215 xcomp investigate,was
R108 T218 T219 det the,role
R109 T219 T217 dobj role,investigate
R110 T220 T219 prep of,role
R111 T221 T223 det the,factors
R112 T222 T223 compound transcription,factors
R113 T223 T220 pobj factors,of
R114 T224 T219 punct ",",role
R115 T225 T233 nmod AP-1,regulation
R116 T226 T225 cc and,AP-1
R117 T227 T225 conj NF-κB,AP-1
R118 T228 T233 punct ",",regulation
R119 T229 T233 prep in,regulation
R120 T230 T229 pobj IL-6,in
R121 T231 T230 cc and,IL-6
R122 T232 T233 compound CXCL8,regulation
R123 T233 T217 dep regulation,investigate
R124 T234 T233 prep in,regulation
R125 T235 T236 compound Jurkat,T-cells
R126 T236 T234 pobj T-cells,in
R127 T237 T215 punct .,was
R128 T238 T246 nsubj Results,resulted
R129 T239 T241 nmod Phorbol,acetate
R130 T240 T241 compound myristate,acetate
R131 T241 T238 appos acetate,Results
R132 T242 T243 punct (,PMA
R133 T243 T241 appos PMA,acetate
R134 T244 T243 punct ),PMA
R135 T245 T246 nsubj exposure,resulted
R136 T246 T246 ROOT resulted,resulted
R137 T247 T246 prep in,resulted
R138 T248 T249 det an,up-regulation
R139 T249 T247 pobj up-regulation,in
R140 T250 T249 prep of,up-regulation
R141 T251 T250 pobj AP-1,of
R142 T252 T251 cc and,AP-1
R143 T253 T251 conj down-regulation,AP-1
R144 T254 T251 prep of,AP-1
R145 T255 T256 amod NF-κB,activity
R146 T256 T254 pobj activity,of
R147 T257 T246 punct ",",resulted
R148 T258 T259 preconj however,","
R149 T259 T246 punct ",",resulted
R150 T260 T267 nmod exposure,Escherichia
R151 T261 T267 prep to,Escherichia
R152 T262 T261 pobj heat,to
R153 T263 T262 dep killed,heat
R154 T264 T263 punct (,killed
R155 T265 T263 npadvmod HK,killed
R156 T266 T267 punct ),Escherichia
R157 T267 T246 dep Escherichia,resulted
R158 T268 T246 punct .,resulted
R159 T269 T270 compound coli,MG1655
R160 T270 T271 nsubj MG1655,resulted
R161 T271 T271 ROOT resulted,resulted
R162 T272 T271 prep in,resulted
R163 T273 T275 det a,increase
R164 T274 T275 amod dose-dependent,increase
R165 T275 T272 pobj increase,in
R166 T276 T275 prep in,increase
R167 T277 T278 amod NF-κB,activity
R168 T278 T276 pobj activity,in
R169 T279 T271 prep without,resulted
R170 T280 T279 pcomp affecting,without
R171 T281 T280 dobj AP-1,affecting
R172 T282 T271 punct .,resulted
R173 T283 T285 det The,profile
R174 T284 T285 compound cytokine,profile
R175 T285 T286 nsubj profile,revealed
R176 T286 T286 ROOT revealed,revealed
R177 T287 T288 det an,up-regulation
R178 T288 T286 dobj up-regulation,revealed
R179 T289 T288 prep of,up-regulation
R180 T290 T292 det the,CXCL8
R181 T291 T292 compound chemokine,CXCL8
R182 T292 T289 pobj CXCL8,of
R183 T293 T292 cc and,CXCL8
R184 T294 T296 det the,cytokines
R185 T295 T296 nsubj pro-inflammatory,cytokines
R186 T296 T292 conj cytokines,CXCL8
R187 T297 T296 conj TNF,cytokines
R188 T298 T297 punct ",",TNF
R189 T299 T297 conj IL-2,TNF
R190 T300 T299 cc and,IL-2
R191 T301 T299 conj IL-6,IL-2
R192 T302 T286 prep following,revealed
R193 T303 T302 pobj treatment,following
R194 T304 T303 prep with,treatment
R195 T305 T306 det both,PMA
R196 T306 T304 pobj PMA,with
R197 T307 T306 cc and,PMA
R198 T308 T310 compound HK,coli
R199 T309 T310 compound E.,coli
R200 T310 T306 conj coli,PMA
R201 T311 T286 punct ",",revealed
R202 T312 T322 mark while,affected
R203 T313 T314 det the,levels
R204 T314 T322 nsubjpass levels,affected
R205 T315 T314 prep of,levels
R206 T316 T319 det the,IL-10
R207 T317 T319 amod anti-inflammatory,IL-10
R208 T318 T319 compound cytokine,IL-10
R209 T319 T315 pobj IL-10,of
R210 T320 T322 auxpass were,affected
R211 T321 T322 neg not,affected
R212 T322 T286 advcl affected,revealed
R213 T323 T322 agent by,affected
R214 T324 T323 pobj PMA,by
R215 T325 T322 cc but,affected
R216 T326 T328 auxpass were,down-regulated
R217 T327 T328 advmod significantly,down-regulated
R218 T328 T322 conj down-regulated,affected
R219 T329 T328 agent by,down-regulated
R220 T330 T332 compound HK,coli
R221 T331 T332 compound E.,coli
R222 T332 T329 pobj coli,by
R223 T333 T286 punct .,revealed
R224 T334 T335 nummod AP-1,activation
R225 T335 T338 nsubjpass activation,increased
R226 T336 T338 auxpass was,increased
R227 T337 T338 advmod significantly,increased
R228 T338 T338 ROOT increased,increased
R229 T339 T340 nummod 2,h
R230 T340 T338 npadvmod h,increased
R231 T341 T338 prep after,increased
R232 T342 T343 compound PMA,exposure
R233 T343 T341 pobj exposure,after
R234 T344 T338 cc and,increased
R235 T345 T338 conj continued,increased
R236 T346 T347 aux to,increase
R237 T347 T345 xcomp increase,continued
R238 T348 T347 advmod thereafter,increase
R239 T349 T338 punct .,increased
R240 T350 T354 prep In,responded
R241 T351 T350 pobj contrast,In
R242 T352 T354 punct ",",responded
R243 T353 T354 nsubj NF-κB,responded
R244 T354 T354 ROOT responded,responded
R245 T355 T354 prep to,responded
R246 T356 T357 compound PMA,exposure
R247 T357 T355 pobj exposure,to
R248 T358 T376 prep by,down-regulation
R249 T359 T357 prep by,exposure
R250 T360 T362 det a,up-regulation
R251 T361 T362 amod rapid,up-regulation
R252 T362 T359 pobj up-regulation,by
R253 T363 T357 acl followed,exposure
R254 T364 T363 agent by,followed
R255 T365 T367 det a,down-regulation
R256 T366 T367 amod subsequent,down-regulation
R257 T367 T364 pobj down-regulation,by
R258 T368 T354 punct .,responded
R259 T369 T373 amod Increased,concentrations
R260 T370 T373 amod intracellular,concentrations
R261 T371 T373 compound Ca2,concentrations
R262 T372 T373 compound +,concentrations
R263 T373 T374 nsubj concentrations,countered
R264 T374 T374 ROOT countered,countered
R265 T375 T376 det the,down-regulation
R266 T376 T374 dobj down-regulation,countered
R267 T377 T376 prep of,down-regulation
R268 T378 T377 pobj NF-κB,of
R269 T379 T358 pobj PMA,by
R270 T380 T374 punct ",",countered
R271 T381 T387 mark while,resulted
R272 T382 T383 amod similar,treatment
R273 T383 T387 nsubj treatment,resulted
R274 T384 T383 prep with,treatment
R275 T385 T386 compound calcium,ionophore
R276 T386 T384 pobj ionophore,with
R277 T387 T374 advcl resulted,countered
R278 T388 T387 prep in,resulted
R279 T389 T392 det a,activity
R280 T390 T392 amod reduced,activity
R281 T391 T392 compound NF-κB,activity
R282 T392 T388 pobj activity,in
R283 T393 T392 acl following,activity
R284 T394 T393 pobj induction,following
R285 T395 T394 prep with,induction
R286 T396 T398 compound HK,coli
R287 T397 T398 compound E.,coli
R288 T398 T395 pobj coli,with
R289 T399 T374 punct .,countered
R290 T400 T409 prep In,considered
R291 T401 T400 pobj order,In
R292 T402 T404 aux to,study
R293 T403 T404 advmod further,study
R294 T404 T409 advcl study,considered
R295 T405 T406 compound NF-κB,activation
R296 T406 T404 dobj activation,study
R297 T407 T409 punct ",",considered
R298 T408 T409 nsubj we,considered
R299 T409 T409 ROOT considered,considered
R300 T410 T413 nummod two,proteins
R301 T411 T413 amod up-stream,proteins
R302 T412 T413 amod signalling,proteins
R303 T413 T409 dobj proteins,considered
R304 T414 T413 punct ",",proteins
R305 T415 T413 appos PKC,proteins
R306 T416 T415 cc and,PKC
R307 T417 T415 conj Bcl10,PKC
R308 T418 T409 punct .,considered
R309 T419 T420 compound Phosphorylated-PKC,levels
R310 T420 T421 nsubj levels,increased
R311 T421 T421 ROOT increased,increased
R312 T422 T421 prep in,increased
R313 T423 T422 pobj response,in
R314 T424 T423 prep to,response
R315 T425 T424 pobj PMA,to
R316 T426 T425 cc and,PMA
R317 T427 T429 compound HK,coli
R318 T428 T429 compound E.,coli
R319 T429 T425 conj coli,PMA
R320 T430 T421 punct ",",increased
R321 T431 T435 mark while,decreased
R322 T432 T433 compound Bcl10,levels
R323 T433 T435 nsubj levels,decreased
R324 T434 T435 advmod significantly,decreased
R325 T435 T421 advcl decreased,increased
R326 T436 T435 prep following,decreased
R327 T437 T438 compound PMA,treatment
R328 T438 T436 pobj treatment,following
R329 T439 T421 punct .,increased
R330 T440 T447 advcl Using,observed
R331 T441 T444 det an,inhibitor
R332 T442 T444 amod NF-κB,inhibitor
R333 T443 T444 compound activation,inhibitor
R334 T444 T440 dobj inhibitor,Using
R335 T445 T447 punct ",",observed
R336 T446 T447 nsubj we,observed
R337 T447 T447 ROOT observed,observed
R338 T448 T449 amod complete,inhibition
R339 T449 T447 dobj inhibition,observed
R340 T450 T449 prep of,inhibition
R341 T451 T452 amod IL-6,expression
R342 T452 T450 pobj expression,of
R343 T453 T457 mark while,decreased
R344 T455 T457 nsubj levels,decreased
R345 T456 T457 advmod only,decreased
R346 T457 T447 advcl decreased,observed
R347 T458 T457 prep by,decreased
R348 T459 T460 nummod 40,%
R349 T460 T458 pobj %,by
R350 T461 T457 prep at,decreased
R351 T462 T464 det the,concentration
R352 T463 T464 amod highest,concentration
R353 T464 T461 pobj concentration,at
R354 T465 T447 punct .,observed
R355 T466 T477 nsubj Treatment,suppressed
R356 T467 T466 prep of,Treatment
R357 T468 T469 compound Jurkat,T-cells
R358 T469 T467 pobj T-cells,of
R359 T470 T466 prep with,Treatment
R360 T471 T470 pobj PMA,with
R361 T472 T466 prep in,Treatment
R362 T473 T474 det the,presence
R363 T474 T472 pobj presence,in
R364 T475 T474 prep of,presence
R365 T476 T477 amod JNK-inhibitor,suppressed
R366 T477 T477 ROOT suppressed,suppressed
R367 T478 T479 preconj both,CXCL8
R368 T479 T477 dobj CXCL8,suppressed
R369 T480 T479 cc and,CXCL8
R370 T481 T479 conj IL-6,CXCL8
R371 T482 T485 mark while,decreased
R372 T483 T485 nsubj PKC-inhibitor,decreased
R373 T484 T485 advmod primarily,decreased
R374 T485 T477 advcl decreased,suppressed
R375 T486 T487 nummod CXCL8,expression
R376 T487 T485 dobj expression,decreased
R377 T488 T477 punct .,suppressed
R378 T489 T493 nsubj Conclusion,shows
R379 T490 T492 det The,study
R380 T491 T492 amod present,study
R381 T492 T493 nsubj study,shows
R382 T493 T493 ROOT shows,shows
R383 T494 T493 dobj that,shows
R384 T495 T497 amod NF-κB,IL-6
R385 T496 T497 amod regulated,IL-6
R386 T497 T494 nsubj IL-6,that
R387 T498 T497 cc but,IL-6
R388 T499 T500 neg not,CXCL8
R389 T500 T497 conj CXCL8,IL-6
R390 T501 T493 punct .,shows
R391 T502 T504 det This,regulation
R392 T503 T504 amod complex,regulation
R393 T504 T507 nsubj regulation,suggests
R394 T505 T504 prep of,regulation
R395 T506 T505 pobj CXCL8,of
R396 T507 T507 ROOT suggests,suggests
R397 T508 T510 mark that,is
R398 T509 T510 expl there,is
R399 T510 T507 ccomp is,suggests
R400 T511 T512 det a,need
R401 T512 T510 attr need,is
R402 T513 T515 aux to,evaluate
R403 T514 T515 advmod further,evaluate
R404 T515 T512 acl evaluate,need
R405 T516 T518 det the,pathways
R406 T517 T518 amod signalling,pathways
R407 T518 T515 dobj pathways,evaluate
R408 T519 T515 prep in,evaluate
R409 T520 T519 pobj order,in
R410 T521 T522 aux to,develop
R411 T522 T520 acl develop,order
R412 T523 T524 amod new,treatment
R413 T524 T522 dobj treatment,develop
R414 T525 T524 prep for,treatment
R415 T526 T525 pobj diseases,for
R416 T527 T526 prep with,diseases
R417 T528 T530 amod elevated,levels
R418 T529 T530 compound CXCL8,levels
R419 T530 T527 pobj levels,with
R420 T531 T530 punct ",",levels
R421 T532 T533 amod such,as
R422 T533 T530 prep as,levels
R423 T534 T533 pobj AIDS,as
R424 T535 T534 cc and,AIDS
R425 T536 T537 amod autoimmune,diseases
R426 T537 T534 conj diseases,AIDS
R427 T538 T507 punct .,suggests
R967 T147 T148 compound Background,Activator
R968 T148 T149 compound Activator,protein
R970 T150 T151 punct (,AP
R971 T151 T149 appos AP,protein
R972 T152 T151 punct ),AP
R973 T153 T151 nummod -1,AP
R974 T154 T149 cc and,protein
R975 T155 T156 amod nuclear,factor
R976 T156 T149 conj factor,protein
R977 T157 T158 punct (,NF
R978 T158 T156 appos NF,factor
R979 T159 T158 punct ),NF
R980 T160 T161 punct -,κB
R981 T161 T165 amod κB,activation
R982 T162 T163 advmod largely,control
R983 T163 T165 amod control,activation
R984 T164 T165 compound T-cell,activation
R987 T454 T455 compound CXCL8,levels
R2410 T3065 T3064 prep of,regulation
R2411 T3066 T3065 pobj AP-1,of
R2412 T3067 T3066 cc and,AP-1

GO-BP

Id Subject Object Predicate Lexical cue
T970 492-502 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T971 590-600 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T972 618-628 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T973 827-837 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T974 1264-1274 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T975 1305-1315 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T976 1380-1390 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T977 2184-2194 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T978 79-96 http://purl.obolibrary.org/obo/GO_0051132 denotes T-cell activation
T979 79-96 http://purl.obolibrary.org/obo/GO_0042110 denotes T-cell activation
T980 79-96 http://purl.obolibrary.org/obo/GO_0050798 denotes T-cell activation
T981 79-96 http://purl.obolibrary.org/obo/GO_0050863 denotes T-cell activation
T982 79-96 http://purl.obolibrary.org/obo/GO_1903905 denotes T-cell activation
T983 81-96 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T984 170-188 http://purl.obolibrary.org/obo/GO_0050663 denotes cytokine secretion
T985 179-188 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T986 435-448 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T987 824-854 http://purl.obolibrary.org/obo/GO_0032722 denotes up-regulation of the chemokine
T988 1445-1454 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T989 1555-1571 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T990 1785-1801 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T991 1601-1611 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T992 2258-2268 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T993 1622-1625 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T994 1652-1655 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T995 2042-2045 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T996 1676-1691 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T997 1785-1811 http://purl.obolibrary.org/obo/GO_1903721 denotes NF-κB activation inhibitor
T998 1991-1994 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T999 2258-2277 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T3781 590-600 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

GO-MF

Id Subject Object Predicate Lexical cue
T1003 108-115 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1004 143-158 http://purl.obolibrary.org/obo/GO_0042608 denotes T-cell receptor
T1005 264-268 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1006 477-481 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1007 910-914 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1008 1848-1852 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1009 2031-2035 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1010 2151-2155 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1011 901-905 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T1012 1016-1021 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T1013 1445-1454 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T1014 1622-1625 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1015 1652-1655 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1016 2042-2045 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T1017 1991-1994 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T1019 515-520 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1020 1957-1962 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1021 143-158 http://purl.obolibrary.org/obo/GO_0042101 denotes T-cell receptor
T1022 1327-1340 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular

sentences

Id Subject Object Predicate Lexical cue
T120 0-10 Sentence denotes Background
T121 11-189 Sentence denotes Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion.
T122 190-377 Sentence denotes Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with several human diseases including cystic fibrosis, pulmonary fibrosis and AIDS.
T123 378-521 Sentence denotes The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-κB, in IL-6 and CXCL8 regulation in Jurkat T-cells.
T124 523-530 Sentence denotes Results
T125 531-790 Sentence denotes Phorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1.
T126 791-1099 Sentence denotes The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli.
T127 1100-1204 Sentence denotes AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter.
T128 1205-1316 Sentence denotes In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation.
T129 1317-1528 Sentence denotes Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli.
T130 1529-1636 Sentence denotes In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10.
T131 1637-1775 Sentence denotes Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment.
T132 1776-1934 Sentence denotes Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration.
T133 1935-2093 Sentence denotes Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression.
T134 2095-2105 Sentence denotes Conclusion
T135 2106-2170 Sentence denotes The present study shows that NF-κB regulated IL-6 but not CXCL8.
T136 2171-2390 Sentence denotes This complex regulation of CXCL8 suggests that there is a need to further evaluate the signalling pathways in order to develop new treatment for diseases with elevated CXCL8 levels, such as AIDS and autoimmune diseases.
T3 0-10 Sentence denotes Background
T4 11-189 Sentence denotes Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion.
T5 190-377 Sentence denotes Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with several human diseases including cystic fibrosis, pulmonary fibrosis and AIDS.
T6 378-521 Sentence denotes The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-κB, in IL-6 and CXCL8 regulation in Jurkat T-cells.
T7 523-530 Sentence denotes Results
T8 531-790 Sentence denotes Phorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, exposure to heat killed (HK) Escherichia. coli MG1655 resulted in a dose-dependent increase in NF-κB activity without affecting AP-1.
T9 791-1099 Sentence denotes The cytokine profile revealed an up-regulation of the chemokine CXCL8 and the pro-inflammatory cytokines TNF, IL-2 and IL-6 following treatment with both PMA and HK E. coli, while the levels of the anti-inflammatory cytokine IL-10 were not affected by PMA but were significantly down-regulated by HK E. coli.
T10 1100-1204 Sentence denotes AP-1 activation was significantly increased 2 h after PMA exposure and continued to increase thereafter.
T11 1205-1316 Sentence denotes In contrast, NF-κB responded to PMA exposure by a rapid up-regulation followed by a subsequent down-regulation.
T12 1317-1528 Sentence denotes Increased intracellular Ca2+ concentrations countered the down-regulation of NF-κB by PMA, while similar treatment with calcium ionophore resulted in a reduced NF-κB activity following induction with HK E. coli.
T13 1529-1636 Sentence denotes In order to further study NF-κB activation, we considered two up-stream signalling proteins, PKC and Bcl10.
T14 1637-1775 Sentence denotes Phosphorylated-PKC levels increased in response to PMA and HK E. coli, while Bcl10 levels significantly decreased following PMA treatment.
T15 1776-1934 Sentence denotes Using an NF-κB activation inhibitor, we observed complete inhibition of IL-6 expression while CXCL8 levels only decreased by 40% at the highest concentration.
T16 1935-2093 Sentence denotes Treatment of Jurkat T-cells with PMA in the presence of JNK-inhibitor suppressed both CXCL8 and IL-6 while PKC-inhibitor primarily decreased CXCL8 expression.
T17 2095-2105 Sentence denotes Conclusion
T18 2106-2170 Sentence denotes The present study shows that NF-κB regulated IL-6 but not CXCL8.
T19 2171-2390 Sentence denotes This complex regulation of CXCL8 suggests that there is a need to further evaluate the signalling pathways in order to develop new treatment for diseases with elevated CXCL8 levels, such as AIDS and autoimmune diseases.

ICD10

Id Subject Object Predicate Lexical cue
T1002 332-358 http://purl.bioontology.org/ontology/ICD10/E84.0 denotes cystic fibrosis, pulmonary
T1000 332-347 http://purl.bioontology.org/ontology/ICD10/E84 denotes cystic fibrosis
T1001 332-347 http://purl.bioontology.org/ontology/ICD10/E84.9 denotes cystic fibrosis

events-check-again

Id Subject Object Predicate Lexical cue Negation
T1212 264-268 Protein denotes IL-6
T1213 273-278 Protein denotes CXCL8
T1214 423-427 Regulation denotes role true
T1215 423-427 Regulation denotes role true
T1216 477-481 Protein denotes IL-6
T1217 486-491 Protein denotes CXCL8
T1218 492-502 Regulation denotes regulation
T1219 492-502 Regulation denotes regulation
T1220 824-837 Positive_regulation denotes up-regulation
T1221 824-837 Positive_regulation denotes up-regulation
T1222 824-837 Positive_regulation denotes up-regulation
T1223 855-860 Protein denotes CXCL8
T1224 901-905 Protein denotes IL-2
T1225 910-914 Protein denotes IL-6
T1226 1016-1021 Protein denotes IL-10
T1227 1031-1039 Regulation denotes affected true
T1228 1070-1084 Negative_regulation denotes down-regulated
T1229 1630-1635 Protein denotes Bcl10
T1230 1714-1719 Protein denotes Bcl10
T1231 1741-1750 Negative_regulation denotes decreased
T1232 1834-1844 Negative_regulation denotes inhibition
T1233 1848-1852 Protein denotes IL-6
T1234 1853-1863 Gene_expression denotes expression
T1235 1870-1875 Protein denotes CXCL8
T1236 1888-1897 Negative_regulation denotes decreased
T1237 2005-2015 Negative_regulation denotes suppressed
T1238 2005-2015 Negative_regulation denotes suppressed
T1239 2021-2026 Protein denotes CXCL8
T1240 2031-2035 Protein denotes IL-6
T1241 2066-2075 Negative_regulation denotes decreased
T1242 2076-2081 Protein denotes CXCL8
T1243 2082-2092 Gene_expression denotes expression
T1244 2141-2150 Regulation denotes regulated true
T1245 2141-2150 Regulation denotes regulated true
T1246 2151-2155 Protein denotes IL-6
T1247 2164-2169 Protein denotes CXCL8
T1248 2184-2194 Regulation denotes regulation
T1249 2198-2203 Protein denotes CXCL8
T1250 2330-2338 Positive_regulation denotes elevated
T1251 2339-2344 Protein denotes CXCL8
R877 T1216 T1219 themeOf IL-6,regulation
R878 T1217 T1218 themeOf CXCL8,regulation
R879 T1218 T1214 themeOf regulation,role
R880 T1219 T1215 themeOf regulation,role
R881 T1223 T1222 themeOf CXCL8,up-regulation
R882 T1224 T1220 themeOf IL-2,up-regulation
R883 T1225 T1221 themeOf IL-6,up-regulation
R884 T1226 T1227 themeOf IL-10,affected
R885 T1226 T1228 themeOf IL-10,down-regulated
R886 T1230 T1231 themeOf Bcl10,decreased
R887 T1233 T1234 themeOf IL-6,expression
R888 T1234 T1232 themeOf expression,inhibition
R889 T1235 T1236 themeOf CXCL8,decreased
R890 T1239 T1237 themeOf CXCL8,suppressed
R891 T1240 T1238 themeOf IL-6,suppressed
R892 T1242 T1243 themeOf CXCL8,expression
R893 T1243 T1241 themeOf expression,decreased
R894 T1246 T1244 themeOf IL-6,regulated
R895 T1247 T1245 themeOf CXCL8,regulated
R896 T1249 T1248 themeOf CXCL8,regulation
R897 T1251 T1250 themeOf CXCL8,elevated

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T1254 60-62 Protein denotes κB
T1255 108-115 Binding denotes binding
T1256 259-262 Protein denotes TNF
T1257 264-268 Protein denotes IL-6
T1258 273-278 Protein denotes CXCL8
T1259 458-462 Protein denotes AP-1
T1260 467-472 Protein denotes NF-κB
T1261 477-481 Protein denotes IL-6
T1262 486-491 Protein denotes CXCL8
T1263 492-502 Regulation denotes regulation
T1264 492-502 Regulation denotes regulation
T1265 423-427 Regulation denotes role
T1266 423-427 Regulation denotes role
T1267 604-608 Protein denotes AP-1
T1268 632-637 Protein denotes NF-κB
T1269 752-757 Protein denotes NF-κB
T1270 785-789 Protein denotes AP-1
T1271 587-600 Positive_regulation denotes up-regulation
T1272 613-628 Negative_regulation denotes down-regulation
T1273 740-748 Positive_regulation denotes increase
T1274 775-784 Regulation denotes affecting
T1275 572-580 Positive_regulation denotes resulted
T1276 572-580 Positive_regulation denotes resulted
T1277 587-600 Positive_regulation denotes up-regulation
T1278 855-860 Protein denotes CXCL8
T1279 886-905 Protein denotes cytokines TNF, IL-2
T1280 910-914 Protein denotes IL-6
T1281 824-837 Positive_regulation denotes up-regulation
T1282 824-837 Positive_regulation denotes up-regulation
T1283 824-837 Positive_regulation denotes up-regulation
T1284 1031-1039 Regulation denotes affected
T1285 1031-1039 Regulation denotes affected
T1286 1031-1039 Regulation denotes affected
T1287 1031-1039 Regulation denotes affected
T1288 1100-1104 Protein denotes AP-1
T1289 1105-1115 Positive_regulation denotes activation
T1290 1134-1143 Positive_regulation denotes increased
T1291 1184-1192 Positive_regulation denotes increase
T1292 1218-1223 Protein denotes NF-κB
T1293 1261-1274 Positive_regulation denotes up-regulation
T1294 1300-1315 Negative_regulation denotes down-regulation
T1295 1261-1274 Positive_regulation denotes up-regulation
T1296 1394-1399 Protein denotes NF-κB
T1297 1477-1482 Protein denotes NF-κB
T1298 1517-1527 Protein denotes HK E. coli
T1299 1375-1390 Negative_regulation denotes down-regulation
T1300 1502-1511 Positive_regulation denotes induction
T1301 1469-1476 Negative_regulation denotes reduced
T1302 1558-1560 Protein denotes κB
T1303 1622-1625 Protein denotes PKC
T1304 1630-1635 Protein denotes Bcl10
T1305 1561-1571 Positive_regulation denotes activation
T1306 1652-1655 Protein denotes PKC
T1307 1637-1651 Phosphorylation denotes Phosphorylated
T1308 1663-1672 Positive_regulation denotes increased
T1309 1663-1672 Positive_regulation denotes increased
T1310 1785-1790 Protein denotes NF-κB
T1311 1848-1852 Protein denotes IL-6
T1312 1870-1875 Protein denotes CXCL8
T1313 1802-1811 Negative_regulation denotes inhibitor
T1314 1853-1863 Gene_expression denotes expression
T1315 1888-1897 Negative_regulation denotes decreased
T1316 1834-1844 Negative_regulation denotes inhibition
T1317 1991-1994 Protein denotes JNK
T1318 2021-2026 Protein denotes CXCL8
T1319 2031-2035 Protein denotes IL-6
T1320 2042-2045 Protein denotes PKC
T1321 2076-2081 Protein denotes CXCL8
T1322 1995-2004 Negative_regulation denotes inhibitor
T1323 2005-2015 Negative_regulation denotes suppressed
T1324 2005-2015 Negative_regulation denotes suppressed
T1325 2046-2055 Negative_regulation denotes inhibitor
T1326 2082-2092 Gene_expression denotes expression
T1327 2066-2075 Negative_regulation denotes decreased
T1328 2135-2140 Protein denotes NF-κB
T1329 2151-2155 Protein denotes IL-6
T1330 2164-2169 Protein denotes CXCL8
T1331 2141-2150 Regulation denotes regulated
T1332 2141-2150 Regulation denotes regulated
T1333 2198-2203 Protein denotes CXCL8
T1334 2339-2344 Protein denotes CXCL8
T1335 2184-2194 Regulation denotes regulation
T1336 2330-2338 Positive_regulation denotes elevated
T3812 604-608 Protein denotes AP-1
T3816 590-600 Regulation denotes regulation
T3817 590-600 Regulation denotes regulation
R898 T1254 T1255 themeOf κB,binding
R899 T1261 T1263 themeOf IL-6,regulation
R900 T1262 T1264 themeOf CXCL8,regulation
R901 T1263 T1265 themeOf regulation,role
R902 T1264 T1266 themeOf regulation,role
R903 T1267 T1271 themeOf AP-1,up-regulation
R904 T1268 T1272 themeOf NF-κB,down-regulation
R905 T1269 T1273 themeOf NF-κB,increase
R906 T1270 T1274 themeOf AP-1,affecting
R907 T1271 T1275 themeOf up-regulation,resulted
R908 T1272 T1276 themeOf down-regulation,resulted
R909 T1272 T1277 themeOf down-regulation,up-regulation
R910 T1278 T1281 themeOf CXCL8,up-regulation
R911 T1279 T1282 themeOf "cytokines TNF, IL-2",up-regulation
R912 T1280 T1283 themeOf IL-6,up-regulation
R913 T1280 T1284 themeOf IL-6,affected
R914 T1281 T1285 themeOf up-regulation,affected
R915 T1282 T1286 themeOf up-regulation,affected
R916 T1283 T1287 themeOf up-regulation,affected
R917 T1288 T1289 themeOf AP-1,activation
R918 T1289 T1290 themeOf activation,increased
R919 T1289 T1291 themeOf activation,increase
R920 T1292 T1293 themeOf NF-κB,up-regulation
R921 T1293 T1294 themeOf up-regulation,down-regulation
R922 T1294 T1295 themeOf down-regulation,up-regulation
R923 T1296 T1299 themeOf NF-κB,down-regulation
R924 T1298 T1300 themeOf HK E. coli,induction
R925 T1300 T1301 themeOf induction,reduced
R926 T1302 T1305 themeOf κB,activation
R927 T1306 T1307 themeOf PKC,Phosphorylated
R928 T1306 T1308 themeOf PKC,increased
R929 T1307 T1309 themeOf Phosphorylated,increased
R930 T1310 T1313 themeOf NF-κB,inhibitor
R931 T1311 T1314 themeOf IL-6,expression
R932 T1312 T1315 themeOf CXCL8,decreased
R933 T1314 T1316 themeOf expression,inhibition
R934 T1317 T1322 themeOf JNK,inhibitor
R935 T1318 T1323 themeOf CXCL8,suppressed
R936 T1319 T1324 themeOf IL-6,suppressed
R937 T1320 T1325 themeOf PKC,inhibitor
R938 T1321 T1326 themeOf CXCL8,expression
R939 T1325 T1327 causeOf inhibitor,decreased
R940 T1326 T1327 themeOf expression,decreased
R941 T1328 T1331 causeOf NF-κB,regulated
R942 T1328 T1332 causeOf NF-κB,regulated
R943 T1329 T1331 themeOf IL-6,regulated
R944 T1330 T1332 themeOf CXCL8,regulated
R945 T1333 T1335 themeOf CXCL8,regulation
R946 T1334 T1336 themeOf CXCL8,elevated

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation
T79 264-268 Protein denotes IL-6
T80 273-278 Protein denotes CXCL8
T81 423-427 Regulation denotes role true
T82 423-427 Regulation denotes role true
T83 477-481 Protein denotes IL-6
T84 486-491 Protein denotes CXCL8
T85 492-502 Regulation denotes regulation
T86 492-502 Regulation denotes regulation
T87 824-837 Positive_regulation denotes up-regulation
T88 824-837 Positive_regulation denotes up-regulation
T89 824-837 Positive_regulation denotes up-regulation
T90 855-860 Protein denotes CXCL8
T91 901-905 Protein denotes IL-2
T92 910-914 Protein denotes IL-6
T93 1016-1021 Protein denotes IL-10
T94 1031-1039 Regulation denotes affected true
T95 1070-1084 Negative_regulation denotes down-regulated
T96 1630-1635 Protein denotes Bcl10
T97 1714-1719 Protein denotes Bcl10
T98 1741-1750 Negative_regulation denotes decreased
T99 1834-1844 Negative_regulation denotes inhibition
T100 1848-1852 Protein denotes IL-6
T101 1853-1863 Gene_expression denotes expression
T102 1870-1875 Protein denotes CXCL8
T103 1888-1897 Negative_regulation denotes decreased
T104 2005-2015 Negative_regulation denotes suppressed
T105 2005-2015 Negative_regulation denotes suppressed
T106 2021-2026 Protein denotes CXCL8
T107 2031-2035 Protein denotes IL-6
T108 2066-2075 Negative_regulation denotes decreased
T109 2076-2081 Protein denotes CXCL8
T110 2082-2092 Gene_expression denotes expression
T111 2141-2150 Regulation denotes regulated true
T112 2141-2150 Regulation denotes regulated true
T113 2151-2155 Protein denotes IL-6
T114 2164-2169 Protein denotes CXCL8
T115 2184-2194 Regulation denotes regulation
T116 2198-2203 Protein denotes CXCL8
T117 2330-2338 Positive_regulation denotes elevated
T118 2339-2344 Protein denotes CXCL8
R45 T83 T86 themeOf IL-6,regulation
R48 T86 T82 themeOf regulation,role
R54 T97 T98 themeOf Bcl10,decreased
R55 T100 T101 themeOf IL-6,expression
R947 T101 T99 themeOf expression,inhibition
R948 T102 T103 themeOf CXCL8,decreased
R949 T106 T104 themeOf CXCL8,suppressed
R950 T107 T105 themeOf IL-6,suppressed
R951 T109 T110 themeOf CXCL8,expression
R952 T110 T108 themeOf expression,decreased
R953 T113 T111 themeOf IL-6,regulated
R954 T114 T112 themeOf CXCL8,regulated
R955 T116 T115 themeOf CXCL8,regulation
R46 T84 T85 themeOf CXCL8,regulation
R47 T85 T81 themeOf regulation,role
R49 T90 T89 themeOf CXCL8,up-regulation
R50 T91 T87 themeOf IL-2,up-regulation
R51 T92 T88 themeOf IL-6,up-regulation
R52 T93 T94 themeOf IL-10,affected
R53 T93 T95 themeOf IL-10,down-regulated
R956 T118 T117 themeOf CXCL8,elevated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T928 382-385 P26358 denotes aim
T929 458-462 P05412 denotes AP-1
T930 477-481 P05231 denotes IL-6
T931 486-491 P10145 denotes CXCL8
T932 604-608 P05412 denotes AP-1
T933 785-789 P05412 denotes AP-1
T934 855-860 P10145 denotes CXCL8
T935 896-899 P01375 denotes TNF
T936 901-905 P60568 denotes IL-2
T937 910-914 P05231 denotes IL-6
T938 1016-1021 P22301 denotes IL-10
T939 1100-1104 P05412 denotes AP-1
T940 1630-1635 O95999 denotes Bcl10
T941 1714-1719 O95999 denotes Bcl10
T942 1848-1852 P05231 denotes IL-6
T943 1870-1875 P10145 denotes CXCL8
T944 2021-2026 P10145 denotes CXCL8
T945 2031-2035 P05231 denotes IL-6
T946 2076-2081 P10145 denotes CXCL8
T947 2151-2155 P05231 denotes IL-6
T948 2164-2169 P10145 denotes CXCL8
T949 2198-2203 P10145 denotes CXCL8
T950 2339-2344 P10145 denotes CXCL8
T3757 604-608 P05412 denotes AP-1
T925 259-262 P01375 denotes TNF
T926 264-268 P05231 denotes IL-6
T927 273-278 P10145 denotes CXCL8

test2

Id Subject Object Predicate Lexical cue Negation
T41 264-268 Protein denotes IL-6 true
T42 273-278 Protein denotes CXCL8
T43 283-293 Binding denotes associated true
T44 423-427 Regulation denotes role
T45 477-481 Protein denotes IL-6
T46 486-491 Protein denotes CXCL8
T47 492-502 Regulation denotes regulation
T48 824-837 Positive_regulation denotes up-regulation true
T49 855-860 Protein denotes CXCL8
T50 901-905 Protein denotes IL-2
T51 910-914 Protein denotes IL-6
T52 915-924 Positive_regulation denotes following
T53 1016-1021 Protein denotes IL-10
T54 1031-1039 Regulation denotes affected
T55 1070-1084 Negative_regulation denotes down-regulated
T56 1630-1635 Protein denotes Bcl10
T57 1714-1719 Protein denotes Bcl10
T58 1741-1750 Negative_regulation denotes decreased true
T59 1834-1844 Negative_regulation denotes inhibition true
T60 1848-1852 Protein denotes IL-6
T61 1853-1863 Gene_expression denotes expression
T62 1870-1875 Protein denotes CXCL8
T63 1888-1897 Negative_regulation denotes decreased
T64 1995-2004 Negative_regulation denotes inhibitor
T65 2005-2015 Negative_regulation denotes suppressed
T66 2021-2026 Protein denotes CXCL8
T67 2031-2035 Protein denotes IL-6
T68 2046-2055 Negative_regulation denotes inhibitor
T69 2066-2075 Negative_regulation denotes decreased
T70 2076-2081 Protein denotes CXCL8
T71 2082-2092 Gene_expression denotes expression
T72 2141-2150 Regulation denotes regulated
T73 2151-2155 Protein denotes IL-6
T74 2164-2169 Protein denotes CXCL8
T75 2184-2194 Regulation denotes regulation
T76 2198-2203 Protein denotes CXCL8
T77 2330-2338 Positive_regulation denotes elevated
T78 2339-2344 Protein denotes CXCL8
R22 T41 T43 themeOf IL-6,associated
R23 T42 T43 themeOf CXCL8,associated
R24 T45 T47 themeOf IL-6,regulation
R25 T46 T47 themeOf CXCL8,regulation
R26 T49 T48 themeOf CXCL8,up-regulation
R27 T50 T48 themeOf IL-2,up-regulation
R28 T51 T48 themeOf IL-6,up-regulation
R29 T53 T54 themeOf IL-10,affected
R30 T53 T55 themeOf IL-10,down-regulated
R31 T57 T58 themeOf Bcl10,decreased
R32 T59 T63 themeOf inhibition,decreased
R33 T60 T61 themeOf IL-6,expression
R34 T61 T63 themeOf expression,decreased
R35 T61 T59 themeOf expression,inhibition
R36 T66 T68 themeOf CXCL8,inhibitor
R37 T66 T65 themeOf CXCL8,suppressed
R38 T67 T65 themeOf IL-6,suppressed
R39 T70 T71 themeOf CXCL8,expression
R40 T71 T69 themeOf expression,decreased
R41 T73 T72 themeOf IL-6,regulated
R42 T74 T72 themeOf CXCL8,regulated
R43 T76 T75 themeOf CXCL8,regulation
R44 T78 T77 themeOf CXCL8,elevated