PMC:2889865 / 5341-8631 JSON TXT

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pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T3422	23-28	NN	denotes	NF-κB
T3423	29-39	NN	denotes	activation
T3424	40-43	DT	denotes	The
T3425	44-57	NN	denotes	transcription
T3426	58-65	NN	denotes	factors
T3427	66-71	NN	denotes	NF-κB
T3428	72-75	CC	denotes	and
T3429	76-80	NN	denotes	AP-1
T3430	81-85	VB	denotes	play
T3431	86-89	JJ	denotes	key
T3432	90-95	NN	denotes	roles
T3433	96-98	IN	denotes	in
T3434	99-102	DT	denotes	the
T3435	103-113	NN	denotes	initiation
T3436	114-116	IN	denotes	of
T3437	117-119	DT	denotes	an
T3438	120-132	JJ	denotes	inflammatory
T3439	133-141	NN	denotes	response
T3440	142-144	IN	denotes	by
T3441	145-153	VB	denotes	inducing
T3442	154-157	DT	denotes	the
T3443	158-168	NN	denotes	expression
T3444	169-172	CC	denotes	and
T3445	173-182	NN	denotes	secretion
T3446	183-185	IN	denotes	of
T3447	186-196	NN	denotes	chemokines
T3448	197-200	CC	denotes	and
T3449	201-210	NN	denotes	cytokines
T3450	211-215	WDT	denotes	that
T3451	216-223	VB	denotes	attract
T3452	224-227	CC	denotes	and
T3453	228-236	VB	denotes	activate
T3454	237-243	JJ	denotes	immune
T3455	244-249	NN	denotes	cells
T3456	251-258	RB	denotes	However
T3457	258-259	-COMMA-	denotes	,
T3458	260-263	DT	denotes	the
T3459	264-270	NN	denotes	signal
T3460	271-283	NN	denotes	transduction
T3461	284-292	NN	denotes	pathways
T3462	293-296	CC	denotes	and
T3463	297-307	JJ	denotes	subsequent
T3464	308-320	JJ	denotes	inflammatory
T3465	321-329	NN	denotes	cytokine
T3466	330-339	NN	denotes	induction
T3467	340-342	IN	denotes	by
T3468	343-348	DT	denotes	these
T3469	349-362	NN	denotes	transcription
T3470	363-370	NN	denotes	factors
T3471	371-373	VB	denotes	is
T3472	374-377	RB	denotes	not
T3473	378-383	RB	denotes	fully
T3474	384-394	VB	denotes	elucidated
T3475	396-399	DT	denotes	The
T3476	400-407	JJ	denotes	present
T3477	408-413	NN	denotes	study
T3478	414-416	VB	denotes	is
T3479	417-422	VB	denotes	aimed
T3480	423-425	IN	denotes	at
T3481	426-437	VB	denotes	determining
T3482	438-441	DT	denotes	the
T3483	442-453	NN	denotes	involvement
T3484	454-456	IN	denotes	of
T3485	457-461	NN	denotes	AP-1
T3486	462-465	CC	denotes	and
T3487	466-471	NN	denotes	NF-κB
T3488	472-474	IN	denotes	in
T3489	475-483	NN	denotes	cytokine
T3490	484-493	NN	denotes	induction
T3491	494-497	CC	denotes	and
T3492	498-508	NN	denotes	regulation
T3493	510-513	NN	denotes	PMA
T3494	514-523	NN	denotes	treatment
T3495	524-532	VB	denotes	resulted
T3496	533-535	IN	denotes	in
T3497	536-538	DT	denotes	an
T3498	539-552	NN	denotes	up-regulation
T3499	553-555	IN	denotes	of
T3500	556-560	NN	denotes	AP-1
T3501	561-566	IN	denotes	after
T3502	567-568	CD	denotes	2
T3503	569-570	NN	denotes	h
T3504	571-579	NN	denotes	exposure
T3505	580-583	CC	denotes	and
T3506	584-593	VB	denotes	continued
T3507	594-596	TO	denotes	to
T3508	597-605	VB	denotes	increase
T3509	606-616	IN	denotes	throughout
T3510	617-620	DT	denotes	the
T3511	621-629	NN	denotes	analysis
T3512	630-636	NN	denotes	period
T3513	637-638	-LRB-	denotes	(
T3514	638-644	NN	denotes	figure
T3515	645-647	NN	denotes	1a
T3516	647-648	-RRB-	denotes	)
T3517	650-652	NN	denotes	HK
T3518	653-655	FW	denotes	E.
T3519	656-660	FW	denotes	coli
T3520	661-670	NN	denotes	treatment
T3521	671-674	VB	denotes	did
T3522	675-678	RB	denotes	not
T3523	679-685	VB	denotes	affect
T3524	686-690	NN	denotes	AP-1
T3525	691-701	NN	denotes	activation
T3526	702-704	IN	denotes	in
T3527	705-711	NN	denotes	Jurkat
T3528	712-719	NN	denotes	T-cells
T3529	720-721	-LRB-	denotes	(
T3530	721-727	NN	denotes	figure
T3531	728-730	NN	denotes	1b
T3532	730-731	-RRB-	denotes	)
T3533	733-735	TO	denotes	To
T3534	736-745	VB	denotes	determine
T3535	746-749	DT	denotes	the
T3536	750-761	NN	denotes	involvement
T3537	762-764	IN	denotes	of
T3538	765-775	VB	denotes	associated
T3539	776-784	NN	denotes	pathways
T3540	784-785	-COMMA-	denotes	,
T3541	786-788	PRP	denotes	we
T3542	789-796	VB	denotes	exposed
T3543	797-802	NN	denotes	cells
T3544	803-805	TO	denotes	to
T3545	806-810	NN	denotes	Ca2+
T3546	811-820	NN	denotes	ionophore
T3547	821-825	IN	denotes	with
T3548	826-828	CC	denotes	or
T3549	829-836	IN	denotes	without
T3550	837-840	NN	denotes	PMA
T3551	841-844	CC	denotes	and
T3552	845-853	VB	denotes	observed
T3553	854-855	DT	denotes	a
T3554	856-862	JJ	denotes	modest
T3555	863-874	NN	denotes	involvement
T3556	875-877	IN	denotes	of
T3557	878-882	NN	denotes	Ca2+
T3558	883-885	IN	denotes	in
T3559	886-899	JJ	denotes	PMA-dependent
T3560	900-904	NN	denotes	AP-1
T3561	905-915	NN	denotes	activation
T3562	916-917	-LRB-	denotes	(
T3563	917-923	NN	denotes	figure
T3564	924-926	NN	denotes	1c
T3565	926-927	-RRB-	denotes	)
T3566	928-933	IN	denotes	while
T3567	934-938	NN	denotes	Ca2+
T3568	939-944	RB	denotes	alone
T3569	945-948	VB	denotes	did
T3570	949-952	RB	denotes	not
T3571	953-958	VB	denotes	alter
T3572	959-963	NN	denotes	AP-1
T3573	964-972	NN	denotes	activity
T3574	973-974	-LRB-	denotes	(
T3575	974-978	NN	denotes	data
T3576	979-982	RB	denotes	not
T3577	983-988	VB	denotes	shown
T3578	988-989	-RRB-	denotes	)
T3579	991-1002	RB	denotes	Furthermore
T3580	1002-1003	-COMMA-	denotes	,
T3581	1004-1008	NN	denotes	AP-1
T3582	1009-1017	NN	denotes	activity
T3583	1018-1027	VB	denotes	decreased
T3584	1028-1030	IN	denotes	in
T3585	1031-1032	DT	denotes	a
T3586	1033-1046	JJ	denotes	TCR-deficient
T3587	1047-1053	NN	denotes	Jurkat
T3588	1054-1058	NN	denotes	cell
T3589	1059-1063	NN	denotes	line
T3590	1064-1068	WRB	denotes	when
T3591	1069-1076	VB	denotes	exposed
T3592	1077-1079	TO	denotes	to
T3593	1080-1083	NN	denotes	PMA
T3594	1084-1092	VB	denotes	compared
T3595	1093-1095	TO	denotes	to
T3596	1096-1099	DT	denotes	the
T3597	1100-1106	NN	denotes	parent
T3598	1107-1111	NN	denotes	cell
T3599	1112-1116	NN	denotes	line
T3600	1117-1127	VB	denotes	indicating
T3601	1128-1132	IN	denotes	that
T3602	1133-1143	NN	denotes	regulation
T3603	1144-1146	IN	denotes	of
T3604	1147-1151	NN	denotes	AP-1
T3605	1152-1155	VB	denotes	was
T3606	1156-1160	RB	denotes	only
T3607	1161-1170	RB	denotes	partially
T3608	1171-1177	NN	denotes	T-cell
T3609	1178-1186	NN	denotes	receptor
T3610	1187-1196	JJ	denotes	dependent
T3611	1197-1198	-LRB-	denotes	(
T3612	1198-1204	NN	denotes	figure
T3613	1205-1207	NN	denotes	1d
T3614	1207-1208	-RRB-	denotes	)
T3615	1847-1852	NN	denotes	NF-κB
T3616	1853-1859	NN	denotes	levels
T3617	1860-1866	VB	denotes	showed
T3618	1867-1868	DT	denotes	a
T3619	1869-1878	JJ	denotes	transient
T3620	1879-1887	NN	denotes	increase
T3621	1888-1890	IN	denotes	at
T3622	1891-1892	CD	denotes	1
T3623	1893-1896	NN	denotes	min
T3624	1897-1902	IN	denotes	after
T3625	1903-1911	NN	denotes	exposure
T3626	1912-1914	TO	denotes	to
T3627	1915-1918	NN	denotes	PMA
T3628	1919-1920	-LRB-	denotes	(
T3629	1920-1926	NN	denotes	figure
T3630	1927-1929	NN	denotes	2a
T3631	1929-1930	-RRB-	denotes	)
T3632	1932-1939	RB	denotes	However
T3633	1939-1940	-COMMA-	denotes	,
T3634	1941-1942	CD	denotes	1
T3635	1943-1944	NN	denotes	h
T3636	1945-1950	IN	denotes	after
T3637	1951-1959	NN	denotes	exposure
T3638	1960-1963	DT	denotes	the
T3639	1964-1969	NN	denotes	NF-κB
T3640	1970-1976	NN	denotes	levels
T3641	1977-1982	VB	denotes	began
T3642	1983-1985	TO	denotes	to
T3643	1986-1990	VB	denotes	drop
T3644	1991-1999	VB	denotes	reaching
T3645	2000-2003	DT	denotes	the
T3646	2004-2010	JJ	denotes	lowest
T3647	2011-2017	NN	denotes	levels
T3648	2018-2020	IN	denotes	by
T3649	2021-2022	CD	denotes	6
T3650	2023-2024	NN	denotes	h
T3651	2024-2025	-COMMA-	denotes	,
T3652	2026-2031	IN	denotes	after
T3653	2032-2037	WDT	denotes	which
T3654	2038-2042	PRP	denotes	they
T3655	2043-2052	VB	denotes	increased
T3656	2053-2058	RB	denotes	again
T3657	2059-2061	IN	denotes	by
T3658	2062-2064	CD	denotes	24
T3659	2065-2066	NN	denotes	h
T3660	2068-2076	NN	denotes	Exposure
T3661	2077-2079	IN	denotes	of
T3662	2080-2086	NN	denotes	Jurkat
T3663	2087-2094	NN	denotes	T-cells
T3664	2095-2097	TO	denotes	to
T3665	2098-2100	NN	denotes	HK
T3666	2101-2103	NNP	denotes	E.
T3667	2104-2108	FW	denotes	coli
T3668	2109-2117	VB	denotes	resulted
T3669	2118-2120	IN	denotes	in
T3670	2121-2122	DT	denotes	a
T3671	2123-2137	JJ	denotes	dose-dependent
T3672	2138-2143	NN	denotes	NF-κB
T3673	2144-2154	NN	denotes	activation
T3674	2154-2155	-COMMA-	denotes	,
T3675	2156-2160	IN	denotes	with
T3676	2161-2164	DT	denotes	the
T3677	2165-2172	JJ	denotes	highest
T3678	2173-2181	NN	denotes	activity
T3679	2182-2190	VB	denotes	observed
T3680	2191-2193	IN	denotes	at
T3681	2194-2195	DT	denotes	a
T3682	2196-2204	JJ	denotes	relative
T3683	2205-2218	NN	denotes	concentration
T3684	2219-2221	IN	denotes	of
T3685	2222-2223	CD	denotes	5
T3686	2224-2225	-COLON-	denotes	×
T3687	2226-2229	CD	denotes	107
T3688	2230-2236	NNP	denotes	CFU/ml
T3689	2237-2238	-LRB-	denotes	(
T3690	2238-2244	NN	denotes	figure
T3691	2245-2247	NN	denotes	2b
T3692	2247-2248	-RRB-	denotes	)
T3693	2250-2253	DT	denotes	The
T3694	2254-2268	JJ	denotes	time-dependent
T3695	2269-2279	NN	denotes	activation
T3696	2280-2282	IN	denotes	of
T3697	2283-2288	NN	denotes	NF-κB
T3698	2289-2291	IN	denotes	by
T3699	2292-2294	NN	denotes	HK
T3700	2295-2297	FW	denotes	E.
T3701	2298-2302	FW	denotes	coli
T3702	2303-2306	VB	denotes	was
T3703	2307-2315	VB	denotes	assessed
T3704	2316-2323	RB	denotes	further
T3705	2324-2329	VB	denotes	using
T3706	2330-2333	DT	denotes	the
T3707	2334-2341	JJ	denotes	optimal
T3708	2342-2355	NN	denotes	concentration
T3709	2356-2364	VB	denotes	obtained
T3710	2365-2369	IN	denotes	from
T3711	2370-2376	NN	denotes	figure
T3712	2377-2379	NN	denotes	2b
T3713	2380-2383	CC	denotes	and
T3714	2384-2390	VB	denotes	showed
T3715	2391-2395	IN	denotes	that
T3716	2396-2399	DT	denotes	the
T3717	2400-2405	NN	denotes	NF-κB
T3718	2406-2414	NN	denotes	activity
T3719	2415-2424	VB	denotes	increased
T3720	2425-2430	IN	denotes	after
T3721	2431-2432	CD	denotes	3
T3722	2433-2434	NN	denotes	h
T3723	2435-2437	IN	denotes	of
T3724	2438-2446	NN	denotes	exposure
T3725	2447-2448	-LRB-	denotes	(
T3726	2448-2454	NN	denotes	figure
T3727	2455-2457	NN	denotes	2c
T3728	2457-2458	-RRB-	denotes	)
T3729	2460-2471	RB	denotes	Furthermore
T3730	2471-2472	-COMMA-	denotes	,
T3731	2473-2482	VB	denotes	increased
T3732	2483-2496	JJ	denotes	intracellular
T3733	2497-2501	NN	denotes	Ca2+
T3734	2502-2510	VB	denotes	reversed
T3735	2511-2514	DT	denotes	the
T3736	2515-2518	NN	denotes	PMA
T3737	2519-2528	JJ	denotes	dependent
T3738	2529-2534	NN	denotes	NF-κB
T3739	2535-2545	NN	denotes	inhibition
T3740	2546-2547	-LRB-	denotes	(
T3741	2547-2553	NN	denotes	figure
T3742	2554-2556	NN	denotes	2d
T3743	2556-2557	-RRB-	denotes	)
T3744	2558-2561	CC	denotes	and
T3745	2562-2569	VB	denotes	reduced
T3746	2570-2573	DT	denotes	the
T3747	2574-2576	NN	denotes	HK
T3748	2577-2579	FW	denotes	E.
T3749	2580-2584	FW	denotes	coli
T3750	2585-2595	JJ	denotes	-dependent
T3751	2596-2601	NN	denotes	NF-κB
T3752	2602-2612	NN	denotes	activation
T3753	2613-2614	-LRB-	denotes	(
T3754	2614-2620	NN	denotes	figure
T3755	2621-2623	NN	denotes	2e
T3756	2623-2624	-RRB-	denotes	)
T15150	1220-1224	NN	denotes	AP-1
T15151	1225-1235	NN	denotes	activation
T15152	1236-1245	VB	denotes	following
T15153	1246-1255	JJ	denotes	long-term
T15154	1256-1264	NN	denotes	exposure
T15155	1265-1267	IN	denotes	of
T15156	1268-1274	NN	denotes	Jurkat
T15157	1275-1282	NN	denotes	T-cells
T15158	1283-1285	TO	denotes	to
T15159	1286-1289	NN	denotes	PMA
T15160	1291-1297	NN	denotes	Jurkat
T15161	1298-1305	NN	denotes	T-cells
T15162	1306-1310	VB	denotes	were
T15163	1311-1322	VB	denotes	transfected
T15164	1323-1327	IN	denotes	with
T15165	1328-1338	NN	denotes	luciferase
T15166	1339-1347	NN	denotes	reporter
T15167	1348-1356	NN	denotes	plasmids
T15168	1357-1367	VB	denotes	containing
T15169	1368-1371	DT	denotes	the
T15170	1372-1376	NN	denotes	AP-1
T15171	1377-1390	NN	denotes	cis-elements.
T15172	1391-1392	-LRB-	denotes	(
T15173	1392-1393	NN	denotes	A
T15174	1393-1394	-RRB-	denotes	)
T15175	1395-1409	JJ	denotes	Time-dependent
T15176	1410-1414	NN	denotes	AP-1
T15177	1415-1425	NN	denotes	activation
T15178	1426-1428	IN	denotes	in
T15179	1429-1437	NN	denotes	response
T15180	1438-1440	TO	denotes	to
T15181	1441-1445	NN	denotes	PMA.
T15182	1446-1447	-LRB-	denotes	(
T15183	1447-1448	NN	denotes	B
T15184	1448-1449	-RRB-	denotes	)
T15185	1450-1452	NN	denotes	HK
T15186	1453-1455	FW	denotes	E.
T15187	1456-1460	FW	denotes	coli
T15188	1461-1465	VB	denotes	does
T15189	1466-1469	RB	denotes	not
T15190	1470-1478	VB	denotes	activate
T15191	1479-1484	NN	denotes	AP-1.
T15192	1485-1486	-LRB-	denotes	(
T15193	1486-1487	NN	denotes	C
T15194	1487-1488	-RRB-	denotes	)
T15195	1489-1503	JJ	denotes	Dose-dependent
T15196	1504-1514	NN	denotes	activation
T15197	1515-1517	IN	denotes	of
T15198	1518-1522	NN	denotes	AP-1
T15199	1523-1527	VB	denotes	were
T15200	1528-1537	VB	denotes	performed
T15201	1538-1543	VB	denotes	using
T15202	1544-1547	NN	denotes	PMA
T15203	1548-1553	RB	denotes	alone
T15204	1554-1555	-LRB-	denotes	(
T15205	1555-1559	JJ	denotes	grey
T15206	1560-1564	NN	denotes	bars
T15207	1564-1565	-RRB-	denotes	)
T15208	1566-1569	CC	denotes	and
T15209	1570-1572	IN	denotes	in
T15210	1573-1584	NN	denotes	combination
T15211	1585-1589	IN	denotes	with
T15212	1590-1597	NN	denotes	calcium
T15213	1598-1607	NN	denotes	ionophore
T15214	1608-1609	-LRB-	denotes	(
T15215	1609-1612	NN	denotes	CaI
T15216	1613-1616	CD	denotes	955
T15217	1617-1619	NN	denotes	μM
T15218	1619-1620	-COMMA-	denotes	,
T15219	1621-1626	JJ	denotes	black
T15220	1627-1631	NN	denotes	bars
T15221	1631-1632	-RRB-	denotes	)
T15222	1632-1633	-LRB-	denotes	.
T15223	1634-1635	NN	denotes	(
T15224	1635-1636	-RRB-	denotes	D
T15225	1636-1642	JJ	denotes	) TCR-
T15226	1642-1651	JJ	denotes	/- defici
T15227	1651-1656	NN	denotes	ent c
T15228	1656-1665	VB	denotes	ells resp
T15229	1665-1667	TO	denotes	on
T15230	1667-1670	NN	denotes	ded
T15231	1671-1672	-LRB-	denotes	t
T15232	1672-1675	CD	denotes	o P
T15233	1675-1677	NN	denotes	MA
T15234	1678-1679	-RRB-	denotes	(
T15235	1679-1681	IN	denotes	16
T15236	1681-1694	VB	denotes	2 nM) by up-r
T15237	1694-1698	NN	denotes	egul
T15238	1698-1706	NN	denotes	ating AP
T15239	1719-1730	JJ	denotes	Statistical
T15240	1731-1743	NN	denotes	significance
T15241	1744-1748	IN	denotes	from
T15242	1749-1752	DT	denotes	the
T15243	1753-1760	NN	denotes	control
T15244	1761-1764	VB	denotes	was
T15245	1765-1775	VB	denotes	determined
T15246	1776-1781	VB	denotes	using
T15247	1782-1789	NN	denotes	Student
T15248	1789-1791	POS	denotes	's
T15249	1792-1799	NN	denotes	t-test.
T15250	1800-1801	-LRB-	denotes	(
T15251	1801-1802	NN	denotes	n
T15252	1803-1804	SYM	denotes	=
T15253	1805-1806	CD	denotes	4
T15254	1806-1807	-RRB-	denotes	)
T15255	1809-1817	NN	denotes	Controls
T15256	1818-1822	VB	denotes	were
T15257	1823-1834	RB	denotes	arbitrarily
T15258	1835-1838	VB	denotes	set
T15259	1839-1841	TO	denotes	to
T15260	1842-1843	CD	denotes	1
T15425	2636-2641	NN	denotes	NF-κB
T15426	2642-2657	NN	denotes	down-regulation
T15427	2658-2660	IN	denotes	by
T15428	2661-2664	NN	denotes	PMA
T15429	2665-2668	CC	denotes	and
T15430	2669-2682	NN	denotes	up-regulation
T15431	2683-2685	IN	denotes	by
T15432	2686-2690	NN	denotes	heat
T15433	2691-2697	VB	denotes	killed
T15434	2698-2700	FW	denotes	E.
T15435	2701-2705	FW	denotes	coli
T15436	2706-2712	NN	denotes	MG1655
T15437	2713-2722	VB	denotes	following
T15438	2723-2732	JJ	denotes	long-term
T15439	2733-2744	NN	denotes	stimulation
T15440	2746-2758	NN	denotes	Transfection
T15441	2759-2761	IN	denotes	of
T15442	2762-2768	NN	denotes	Jurkat
T15443	2769-2776	NN	denotes	T-cells
T15444	2777-2780	VB	denotes	was
T15445	2781-2790	VB	denotes	performed
T15446	2791-2796	VB	denotes	using
T15447	2797-2807	NN	denotes	luciferase
T15448	2808-2816	NN	denotes	reporter
T15449	2817-2825	NN	denotes	plasmids
T15450	2826-2836	VB	denotes	containing
T15451	2837-2842	NN	denotes	NF-κB
T15452	2843-2856	NN	denotes	cis-elements.
T15453	2857-2858	-LRB-	denotes	(
T15454	2858-2859	NN	denotes	A
T15455	2859-2860	-RRB-	denotes	)
T15456	2861-2875	JJ	denotes	Time-dependent
T15457	2876-2887	NN	denotes	stimulation
T15458	2888-2890	IN	denotes	of
T15459	2891-2897	NN	denotes	Jurkat
T15460	2898-2905	NN	denotes	T-cells
T15461	2906-2911	VB	denotes	using
T15462	2912-2915	NN	denotes	PMA
T15463	2917-2922	NN	denotes	NF-κB
T15464	2923-2933	NN	denotes	activation
T15465	2934-2937	VB	denotes	was
T15466	2938-2947	VB	denotes	evaluated
T15467	2948-2953	VB	denotes	using
T15468	2954-2956	NNP	denotes	HK
T15469	2957-2959	NNP	denotes	E.
T15470	2960-2964	NNP	denotes	coli
T15471	2965-2967	IN	denotes	in
T15472	2968-2969	DT	denotes	a
T15473	2970-2971	-LRB-	denotes	(
T15474	2971-2972	NN	denotes	B
T15475	2972-2973	-RRB-	denotes	)
T15476	2974-2979	NN	denotes	dose-
T15477	2980-2983	CC	denotes	and
T15478	2984-2985	-LRB-	denotes	(
T15479	2985-2986	NN	denotes	C
T15480	2986-2987	-RRB-	denotes	)
T15481	2988-3002	JJ	denotes	time-dependant
T15482	3003-3009	NN	denotes	manner
T15483	3011-3018	NN	denotes	Calcium
T15484	3019-3028	NN	denotes	ionophore
T15485	3029-3038	VB	denotes	increased
T15486	3039-3044	NN	denotes	NF-κB
T15487	3045-3053	NN	denotes	activity
T15488	3054-3063	VB	denotes	following
T15489	3064-3067	NN	denotes	PMA
T15490	3068-3076	NN	denotes	exposure
T15491	3077-3078	-LRB-	denotes	(
T15492	3078-3079	NN	denotes	E
T15493	3079-3080	-RRB-	denotes	)
T15494	3081-3084	CC	denotes	and
T15495	3085-3093	VB	denotes	resulted
T15496	3094-3096	IN	denotes	in
T15497	3097-3098	DT	denotes	a
T15498	3099-3107	JJ	denotes	negative
T15499	3108-3118	NN	denotes	regulation
T15500	3119-3121	IN	denotes	in
T15501	3122-3130	NN	denotes	response
T15502	3131-3133	TO	denotes	to
T15503	3134-3136	NN	denotes	HK
T15504	3137-3139	FW	denotes	E.
T15505	3140-3144	FW	denotes	coli
T15506	3145-3156	NN	denotes	stimulation
T15507	3157-3158	-LRB-	denotes	(
T15508	3158-3159	NN	denotes	D
T15509	3159-3160	-RRB-	denotes	)
T15510	3162-3173	JJ	denotes	Statistical
T15511	3174-3186	NN	denotes	significance
T15512	3187-3191	IN	denotes	from
T15513	3192-3195	DT	denotes	the
T15514	3196-3203	NN	denotes	control
T15515	3204-3207	VB	denotes	was
T15516	3208-3218	VB	denotes	determined
T15517	3219-3224	VB	denotes	using
T15518	3225-3232	NN	denotes	Student
T15519	3232-3234	POS	denotes	's
T15520	3235-3242	NN	denotes	t-test.
T15521	3243-3244	-LRB-	denotes	(
T15522	3244-3245	NN	denotes	n
T15523	3246-3247	SYM	denotes	=
T15524	3248-3249	CD	denotes	4
T15525	3249-3250	-RRB-	denotes	)
T15526	3252-3260	NN	denotes	Controls
T15527	3261-3265	VB	denotes	were
T15528	3266-3277	RB	denotes	arbitrarily
T15529	3278-3281	VB	denotes	set
T15530	3282-3284	TO	denotes	to
T15531	3285-3286	CD	denotes	1
R2767	T3423	T3422	arg1Of	activation,NF-κB
R2768	T3426	T3424	arg1Of	factors,The
R2769	T3426	T3425	arg1Of	factors,transcription
R2770	T3427	T3428	arg1Of	NF-κB,and
R2771	T3428	T3426	arg1Of	and,factors
R2772	T3428	T3430	arg1Of	and,play
R2773	T3428	T3441	arg1Of	and,inducing
R2774	T3429	T3428	arg2Of	AP-1,and
R2775	T3430	T3433	arg1Of	play,in
R2776	T3430	T3440	arg1Of	play,by
R2777	T3432	T3430	arg2Of	roles,play
R2778	T3432	T3431	arg1Of	roles,key
R2779	T3435	T3433	arg2Of	initiation,in
R2780	T3435	T3434	arg1Of	initiation,the
R2781	T3435	T3436	arg1Of	initiation,of
R2782	T3439	T3436	arg2Of	response,of
R2783	T3439	T3437	arg1Of	response,an
R2784	T3439	T3438	arg1Of	response,inflammatory
R2785	T3441	T3440	arg2Of	inducing,by
R2786	T3443	T3444	arg1Of	expression,and
R2787	T3444	T3441	arg2Of	and,inducing
R2788	T3444	T3442	arg1Of	and,the
R2789	T3444	T3446	arg1Of	and,of
R2790	T3445	T3444	arg2Of	secretion,and
R2791	T3447	T3448	arg1Of	chemokines,and
R2792	T3448	T3446	arg2Of	and,of
R2793	T3448	T3450	arg1Of	and,that
R2794	T3448	T3451	arg1Of	and,attract
R2795	T3448	T3453	arg1Of	and,activate
R2796	T3449	T3448	arg2Of	cytokines,and
R2797	T3451	T3452	arg1Of	attract,and
R2798	T3453	T3452	arg2Of	activate,and
R2799	T3455	T3451	arg2Of	cells,attract
R2800	T3455	T3453	arg2Of	cells,activate
R2801	T3455	T3454	arg1Of	cells,immune
R2802	T3461	T3459	arg1Of	pathways,signal
R2803	T3461	T3460	arg1Of	pathways,transduction
R2804	T3461	T3462	arg1Of	pathways,and
R2805	T3462	T3458	arg1Of	and,the
R2806	T3462	T3471	arg1Of	and,is
R2807	T3462	T3474	arg2Of	and,elucidated
R2808	T3466	T3462	arg2Of	induction,and
R2809	T3466	T3463	arg1Of	induction,subsequent
R2810	T3466	T3464	arg1Of	induction,inflammatory
R2811	T3466	T3465	arg1Of	induction,cytokine
R2812	T3466	T3467	arg1Of	induction,by
R2813	T3470	T3467	arg2Of	factors,by
R2814	T3470	T3468	arg1Of	factors,these
R2815	T3470	T3469	arg1Of	factors,transcription
R2816	T3474	T3456	arg1Of	elucidated,However
R2817	T3474	T3457	arg1Of	elucidated,","
R2818	T3474	T3471	arg2Of	elucidated,is
R2819	T3474	T3472	arg1Of	elucidated,not
R2820	T3474	T3473	arg1Of	elucidated,fully
R2821	T3477	T3475	arg1Of	study,The
R2822	T3477	T3476	arg1Of	study,present
R2823	T3477	T3478	arg1Of	study,is
R2824	T3477	T3479	arg2Of	study,aimed
R2825	T3479	T3478	arg2Of	aimed,is
R2826	T3479	T3480	arg1Of	aimed,at
R2827	T3481	T3480	arg2Of	determining,at
R2828	T3483	T3481	arg2Of	involvement,determining
R2829	T3483	T3482	arg1Of	involvement,the
R2830	T3483	T3484	arg1Of	involvement,of
R2831	T3483	T3488	arg1Of	involvement,in
R2832	T3485	T3486	arg1Of	AP-1,and
R2833	T3486	T3484	arg2Of	and,of
R2834	T3487	T3486	arg2Of	NF-κB,and
R2835	T3490	T3491	arg1Of	induction,and
R2836	T3491	T3488	arg2Of	and,in
R2837	T3491	T3489	arg1Of	and,cytokine
R2838	T3492	T3491	arg2Of	regulation,and
R2839	T3494	T3493	arg1Of	treatment,PMA
R2840	T3494	T3495	arg1Of	treatment,resulted
R2841	T3494	T3506	arg1Of	treatment,continued
R2842	T3494	T3508	arg1Of	treatment,increase
R2843	T3495	T3496	arg1Of	resulted,in
R2844	T3495	T3501	arg1Of	resulted,after
R2845	T3495	T3505	arg1Of	resulted,and
R2846	T3498	T3496	arg2Of	up-regulation,in
R2847	T3498	T3497	arg1Of	up-regulation,an
R2848	T3498	T3499	arg1Of	up-regulation,of
R2849	T3500	T3499	arg2Of	AP-1,of
R2850	T3504	T3501	arg2Of	exposure,after
R2851	T3504	T3502	arg1Of	exposure,2
R2852	T3504	T3503	arg1Of	exposure,h
R2853	T3506	T3505	arg2Of	continued,and
R2854	T3508	T3506	arg2Of	increase,continued
R2855	T3508	T3507	arg1Of	increase,to
R2856	T3508	T3509	arg1Of	increase,throughout
R2857	T3512	T3509	arg2Of	period,throughout
R2858	T3512	T3510	arg1Of	period,the
R2859	T3512	T3511	arg1Of	period,analysis
R2860	T3512	T3513	arg1Of	period,(
R2861	T3515	T3513	arg2Of	1a,(
R2862	T3515	T3514	arg1Of	1a,figure
R2863	T3516	T3513	arg3Of	),(
R2864	T3520	T3517	arg1Of	treatment,HK
R2865	T3520	T3518	arg1Of	treatment,E.
R2866	T3520	T3519	arg1Of	treatment,coli
R2867	T3520	T3521	arg1Of	treatment,did
R2868	T3520	T3523	arg1Of	treatment,affect
R2869	T3523	T3521	arg2Of	affect,did
R2870	T3523	T3522	arg1Of	affect,not
R2871	T3523	T3526	arg1Of	affect,in
R2872	T3525	T3523	arg2Of	activation,affect
R2873	T3525	T3524	arg1Of	activation,AP-1
R2874	T3528	T3526	arg2Of	T-cells,in
R2875	T3528	T3527	arg1Of	T-cells,Jurkat
R2876	T3528	T3529	arg1Of	T-cells,(
R2877	T3531	T3529	arg2Of	1b,(
R2878	T3531	T3530	arg1Of	1b,figure
R2879	T3532	T3529	arg3Of	),(
R2880	T3534	T3533	arg1Of	determine,To
R2881	T3536	T3534	arg2Of	involvement,determine
R2882	T3536	T3535	arg1Of	involvement,the
R2883	T3536	T3537	arg1Of	involvement,of
R2884	T3539	T3537	arg2Of	pathways,of
R2885	T3539	T3538	arg2Of	pathways,associated
R2886	T3541	T3542	arg1Of	we,exposed
R2887	T3541	T3552	arg1Of	we,observed
R2888	T3542	T3544	arg1Of	exposed,to
R2889	T3542	T3547	arg1Of	exposed,with
R2890	T3542	T3549	arg1Of	exposed,without
R2891	T3542	T3551	arg1Of	exposed,and
R2892	T3543	T3542	arg2Of	cells,exposed
R2893	T3546	T3544	arg2Of	ionophore,to
R2894	T3546	T3545	arg1Of	ionophore,Ca2+
R2895	T3547	T3548	arg1Of	with,or
R2896	T3549	T3548	arg2Of	without,or
R2897	T3550	T3547	arg2Of	PMA,with
R2898	T3550	T3549	arg2Of	PMA,without
R2899	T3551	T3533	modOf	and,To
R2900	T3551	T3540	arg1Of	and,","
R2901	T3552	T3551	arg2Of	observed,and
R2902	T3552	T3566	arg1Of	observed,while
R2903	T3555	T3552	arg2Of	involvement,observed
R2904	T3555	T3553	arg1Of	involvement,a
R2905	T3555	T3554	arg1Of	involvement,modest
R2906	T3555	T3556	arg1Of	involvement,of
R2907	T3555	T3558	arg1Of	involvement,in
R2908	T3557	T3556	arg2Of	Ca2+,of
R2909	T3561	T3558	arg2Of	activation,in
R2910	T3561	T3559	arg1Of	activation,PMA-dependent
R2911	T3561	T3560	arg1Of	activation,AP-1
R2912	T3561	T3562	arg1Of	activation,(
R2913	T3564	T3562	arg2Of	1c,(
R2914	T3564	T3563	arg1Of	1c,figure
R2915	T3565	T3562	arg3Of	),(
R2916	T3567	T3568	arg1Of	Ca2+,alone
R2917	T3567	T3569	arg1Of	Ca2+,did
R2918	T3567	T3571	arg1Of	Ca2+,alter
R2919	T3571	T3566	arg2Of	alter,while
R2920	T3571	T3569	arg2Of	alter,did
R2921	T3571	T3570	arg1Of	alter,not
R2922	T3573	T3571	arg2Of	activity,alter
R2923	T3573	T3572	arg1Of	activity,AP-1
R2924	T3573	T3574	arg1Of	activity,(
R2925	T3575	T3574	arg2Of	data,(
R2926	T3575	T3577	arg2Of	data,shown
R2927	T3577	T3576	arg1Of	shown,not
R2928	T3578	T3574	arg3Of	),(
R2929	T3582	T3581	arg1Of	activity,AP-1
R2930	T3582	T3583	arg1Of	activity,decreased
R2931	T3582	T3591	arg1Of	activity,exposed
R2932	T3583	T3579	arg1Of	decreased,Furthermore
R2933	T3583	T3580	arg1Of	decreased,","
R2934	T3583	T3584	arg1Of	decreased,in
R2935	T3583	T3590	arg1Of	decreased,when
R2936	T3589	T3584	arg2Of	line,in
R2937	T3589	T3585	arg1Of	line,a
R2938	T3589	T3586	arg1Of	line,TCR-deficient
R2939	T3589	T3587	arg1Of	line,Jurkat
R2940	T3589	T3588	arg1Of	line,cell
R2941	T3591	T3590	arg2Of	exposed,when
R2942	T3591	T3592	arg1Of	exposed,to
R2943	T3591	T3594	arg1Of	exposed,compared
R2944	T3593	T3592	arg2Of	PMA,to
R2945	T3595	T3594	arg2Of	to,compared
R2946	T3599	T3595	arg2Of	line,to
R2947	T3599	T3596	arg1Of	line,the
R2948	T3599	T3597	arg1Of	line,parent
R2949	T3599	T3598	arg1Of	line,cell
R2950	T3599	T3600	arg1Of	line,indicating
R2951	T3599	T3611	arg1Of	line,(
R2952	T3602	T3603	arg1Of	regulation,of
R2953	T3602	T3605	arg1Of	regulation,was
R2954	T3602	T3610	arg1Of	regulation,dependent
R2955	T3604	T3603	arg2Of	AP-1,of
R2956	T3605	T3600	arg2Of	was,indicating
R2957	T3605	T3601	arg1Of	was,that
R2958	T3605	T3607	arg1Of	was,partially
R2959	T3607	T3606	arg1Of	partially,only
R2960	T3609	T3608	arg1Of	receptor,T-cell
R2961	T3610	T3605	arg2Of	dependent,was
R2962	T3610	T3609	arg1Of	dependent,receptor
R2963	T3613	T3611	arg2Of	1d,(
R2964	T3613	T3612	arg1Of	1d,figure
R2965	T3614	T3611	arg3Of	),(
R2966	T3616	T3615	arg1Of	levels,NF-κB
R2967	T3616	T3617	arg1Of	levels,showed
R2968	T3617	T3624	arg1Of	showed,after
R2969	T3620	T3617	arg2Of	increase,showed
R2970	T3620	T3618	arg1Of	increase,a
R2971	T3620	T3619	arg1Of	increase,transient
R2972	T3620	T3621	arg1Of	increase,at
R2973	T3623	T3621	arg2Of	min,at
R2974	T3623	T3622	arg1Of	min,1
R2975	T3625	T3624	arg2Of	exposure,after
R2976	T3625	T3626	arg1Of	exposure,to
R2977	T3627	T3626	arg2Of	PMA,to
R2978	T3627	T3628	arg1Of	PMA,(
R2979	T3630	T3628	arg2Of	2a,(
R2980	T3630	T3629	arg1Of	2a,figure
R2981	T3631	T3628	arg3Of	),(
R2982	T3635	T3634	arg1Of	h,1
R2983	T3635	T3644	arg1Of	h,reaching
R2984	T3637	T3636	arg2Of	exposure,after
R2985	T3637	T3643	arg2Of	exposure,drop
R2986	T3640	T3638	arg1Of	levels,the
R2987	T3640	T3639	arg1Of	levels,NF-κB
R2988	T3640	T3641	arg1Of	levels,began
R2989	T3640	T3643	arg1Of	levels,drop
R2990	T3643	T3641	arg2Of	drop,began
R2991	T3643	T3642	arg1Of	drop,to
R2992	T3644	T3632	arg1Of	reaching,However
R2993	T3644	T3633	arg1Of	reaching,","
R2994	T3644	T3636	arg1Of	reaching,after
R2995	T3644	T3648	arg1Of	reaching,by
R2996	T3647	T3644	arg2Of	levels,reaching
R2997	T3647	T3645	arg1Of	levels,the
R2998	T3647	T3646	arg1Of	levels,lowest
R2999	T3650	T3648	arg2Of	h,by
R3000	T3650	T3649	arg1Of	h,6
R3001	T3650	T3651	arg1Of	h,","
R3002	T3650	T3652	arg2Of	h,after
R3003	T3650	T3653	arg1Of	h,which
R3004	T3654	T3655	arg1Of	they,increased
R3005	T3655	T3652	arg1Of	increased,after
R3006	T3655	T3656	arg1Of	increased,again
R3007	T3655	T3657	arg1Of	increased,by
R3008	T3659	T3657	arg2Of	h,by
R3009	T3659	T3658	arg1Of	h,24
R3010	T3660	T3661	arg1Of	Exposure,of
R3011	T3660	T3664	arg1Of	Exposure,to
R3012	T3660	T3668	arg1Of	Exposure,resulted
R3013	T3663	T3661	arg2Of	T-cells,of
R3014	T3663	T3662	arg1Of	T-cells,Jurkat
R3015	T3666	T3664	arg2Of	E.,to
R3016	T3666	T3665	arg1Of	E.,HK
R3017	T3666	T3667	arg1Of	E.,coli
R3018	T3668	T3669	arg1Of	resulted,in
R3019	T3668	T3674	arg1Of	resulted,","
R3020	T3668	T3675	arg1Of	resulted,with
R3021	T3668	T3688	arg1Of	resulted,CFU/ml
R3022	T3673	T3669	arg2Of	activation,in
R3023	T3673	T3670	arg1Of	activation,a
R3024	T3673	T3671	arg1Of	activation,dose-dependent
R3025	T3673	T3672	arg1Of	activation,NF-κB
R3026	T3678	T3675	arg2Of	activity,with
R3027	T3678	T3676	arg1Of	activity,the
R3028	T3678	T3677	arg1Of	activity,highest
R3029	T3678	T3679	arg2Of	activity,observed
R3030	T3679	T3675	arg3Of	observed,with
R3031	T3679	T3680	arg1Of	observed,at
R3032	T3683	T3680	arg2Of	concentration,at
R3033	T3683	T3681	arg1Of	concentration,a
R3034	T3683	T3682	arg1Of	concentration,relative
R3035	T3683	T3684	arg1Of	concentration,of
R3036	T3685	T3684	arg2Of	5,of
R3037	T3688	T3686	arg1Of	CFU/ml,×
R3038	T3688	T3687	arg1Of	CFU/ml,107
R3039	T3688	T3689	arg1Of	CFU/ml,(
R3040	T3691	T3689	arg2Of	2b,(
R3041	T3691	T3690	arg1Of	2b,figure
R3042	T3692	T3689	arg3Of	),(
R3043	T3695	T3693	arg1Of	activation,The
R3044	T3695	T3694	arg1Of	activation,time-dependent
R3045	T3695	T3696	arg1Of	activation,of
R3046	T3695	T3698	arg1Of	activation,by
R3047	T3695	T3702	arg1Of	activation,was
R3048	T3695	T3703	arg2Of	activation,assessed
R3049	T3695	T3714	arg1Of	activation,showed
R3050	T3697	T3696	arg2Of	NF-κB,of
R3051	T3701	T3698	arg2Of	coli,by
R3052	T3701	T3699	arg1Of	coli,HK
R3053	T3701	T3700	arg1Of	coli,E.
R3054	T3703	T3702	arg2Of	assessed,was
R3055	T3703	T3704	arg1Of	assessed,further
R3056	T3703	T3713	arg1Of	assessed,and
R3057	T3705	T3703	arg3Of	using,assessed
R3058	T3708	T3705	arg2Of	concentration,using
R3059	T3708	T3706	arg1Of	concentration,the
R3060	T3708	T3707	arg1Of	concentration,optimal
R3061	T3708	T3709	arg2Of	concentration,obtained
R3062	T3709	T3710	arg1Of	obtained,from
R3063	T3712	T3710	arg2Of	2b,from
R3064	T3712	T3711	arg1Of	2b,figure
R3065	T3714	T3713	arg2Of	showed,and
R3066	T3718	T3716	arg1Of	activity,the
R3067	T3718	T3717	arg1Of	activity,NF-κB
R3068	T3718	T3719	arg1Of	activity,increased
R3069	T3719	T3714	arg2Of	increased,showed
R3070	T3719	T3715	arg1Of	increased,that
R3071	T3719	T3720	arg1Of	increased,after
R3072	T3722	T3720	arg2Of	h,after
R3073	T3722	T3721	arg1Of	h,3
R3074	T3722	T3723	arg1Of	h,of
R3075	T3724	T3723	arg2Of	exposure,of
R3076	T3724	T3725	arg1Of	exposure,(
R3077	T3727	T3725	arg2Of	2c,(
R3078	T3727	T3726	arg1Of	2c,figure
R3079	T3728	T3725	arg3Of	),(
R3080	T3733	T3731	arg2Of	Ca2+,increased
R3081	T3733	T3732	arg1Of	Ca2+,intracellular
R3082	T3733	T3734	arg1Of	Ca2+,reversed
R3083	T3733	T3745	arg1Of	Ca2+,reduced
R3084	T3734	T3744	arg1Of	reversed,and
R3085	T3739	T3734	arg2Of	inhibition,reversed
R3086	T3739	T3735	arg1Of	inhibition,the
R3087	T3739	T3736	arg1Of	inhibition,PMA
R3088	T3739	T3737	arg1Of	inhibition,dependent
R3089	T3739	T3738	arg1Of	inhibition,NF-κB
R3090	T3739	T3740	arg1Of	inhibition,(
R3091	T3742	T3740	arg2Of	2d,(
R3092	T3742	T3741	arg1Of	2d,figure
R3093	T3743	T3740	arg3Of	),(
R3094	T3744	T3729	arg1Of	and,Furthermore
R3095	T3744	T3730	arg1Of	and,","
R3096	T3745	T3744	arg2Of	reduced,and
R3097	T3752	T3745	arg2Of	activation,reduced
R3098	T3752	T3746	arg1Of	activation,the
R3099	T3752	T3747	arg1Of	activation,HK
R3100	T3752	T3748	arg1Of	activation,E.
R3101	T3752	T3749	arg1Of	activation,coli
R3102	T3752	T3750	arg1Of	activation,-dependent
R3103	T3752	T3751	arg1Of	activation,NF-κB
R3104	T3752	T3753	arg1Of	activation,(
R3105	T3755	T3753	arg2Of	2e,(
R3106	T3755	T3754	arg1Of	2e,figure
R3107	T3756	T3753	arg3Of	),(
R12300	T15151	T15150	arg1Of	activation,AP-1
R12301	T15151	T15152	arg1Of	activation,following
R12302	T15154	T15152	arg2Of	exposure,following
R12303	T15154	T15153	arg1Of	exposure,long-term
R12304	T15154	T15155	arg1Of	exposure,of
R12305	T15154	T15158	arg1Of	exposure,to
R12306	T15157	T15155	arg2Of	T-cells,of
R12307	T15157	T15156	arg1Of	T-cells,Jurkat
R12308	T15159	T15158	arg2Of	PMA,to
R12309	T15161	T15160	arg1Of	T-cells,Jurkat
R12310	T15161	T15162	arg1Of	T-cells,were
R12311	T15161	T15163	arg2Of	T-cells,transfected
R12312	T15163	T15162	arg2Of	transfected,were
R12313	T15163	T15164	arg1Of	transfected,with
R12314	T15167	T15164	arg2Of	plasmids,with
R12315	T15167	T15165	arg1Of	plasmids,luciferase
R12316	T15167	T15166	arg1Of	plasmids,reporter
R12317	T15167	T15168	arg1Of	plasmids,containing
R12318	T15167	T15214	arg1Of	plasmids,(
R12319	T15168	T15178	arg1Of	containing,in
R12320	T15168	T15209	arg1Of	containing,in
R12321	T15173	T15172	arg2Of	A,(
R12322	T15174	T15172	arg3Of	),(
R12323	T15177	T15168	arg2Of	activation,containing
R12324	T15177	T15169	arg1Of	activation,the
R12325	T15177	T15170	arg1Of	activation,AP-1
R12326	T15177	T15171	arg1Of	activation,cis-elements.
R12327	T15177	T15172	arg1Of	activation,(
R12328	T15177	T15175	arg1Of	activation,Time-dependent
R12329	T15177	T15176	arg1Of	activation,AP-1
R12330	T15178	T15208	arg1Of	in,and
R12331	T15179	T15178	arg2Of	response,in
R12332	T15179	T15180	arg1Of	response,to
R12333	T15181	T15180	arg2Of	PMA.,to
R12334	T15181	T15182	arg1Of	PMA.,(
R12335	T15181	T15185	arg1Of	PMA.,HK
R12336	T15181	T15190	arg2Of	PMA.,activate
R12337	T15183	T15182	arg2Of	B,(
R12338	T15184	T15182	arg3Of	),(
R12339	T15187	T15186	arg1Of	coli,E.
R12340	T15187	T15188	arg1Of	coli,does
R12341	T15187	T15190	arg1Of	coli,activate
R12342	T15190	T15188	arg2Of	activate,does
R12343	T15190	T15189	arg1Of	activate,not
R12344	T15191	T15178	arg3Of	AP-1.,in
R12345	T15191	T15199	modOf	AP-1.,were
R12346	T15193	T15192	arg2Of	C,(
R12347	T15194	T15192	arg3Of	),(
R12348	T15196	T15192	arg1Of	activation,(
R12349	T15196	T15195	arg1Of	activation,Dose-dependent
R12350	T15196	T15197	arg1Of	activation,of
R12351	T15196	T15199	arg1Of	activation,were
R12352	T15196	T15200	arg2Of	activation,performed
R12353	T15198	T15197	arg2Of	AP-1,of
R12354	T15200	T15199	arg2Of	performed,were
R12355	T15201	T15200	arg3Of	using,performed
R12356	T15202	T15201	arg2Of	PMA,using
R12357	T15202	T15203	arg1Of	PMA,alone
R12358	T15202	T15204	arg1Of	PMA,(
R12359	T15206	T15204	arg2Of	bars,(
R12360	T15206	T15205	arg1Of	bars,grey
R12361	T15207	T15204	arg3Of	),(
R12362	T15209	T15208	arg2Of	in,and
R12363	T15210	T15209	arg2Of	combination,in
R12364	T15210	T15211	arg1Of	combination,with
R12365	T15213	T15211	arg2Of	ionophore,with
R12366	T15213	T15212	arg1Of	ionophore,calcium
R12367	T15217	T15214	arg2Of	μM,(
R12368	T15217	T15215	arg1Of	μM,CaI
R12369	T15217	T15216	arg1Of	μM,955
R12370	T15217	T15218	arg1Of	μM,","
R12371	T15220	T15218	arg2Of	bars,","
R12372	T15220	T15219	arg1Of	bars,black
R12373	T15221	T15214	arg3Of	),(
R12374	T15223	T15222	arg2Of	(,.
R12375	T15224	T15222	arg3Of	D,.
R12376	T15227	T15222	arg1Of	ent c,.
R12377	T15227	T15225	arg1Of	ent c,) TCR-
R12378	T15227	T15226	arg1Of	ent c,/- defici
R12379	T15227	T15228	arg1Of	ent c,ells resp
R12380	T15227	T15236	arg1Of	ent c,2 nM) by up-r
R12381	T15228	T15162	modOf	ells resp,were
R12382	T15228	T15229	arg1Of	ells resp,on
R12383	T15228	T15235	arg1Of	ells resp,16
R12384	T15230	T15229	arg2Of	ded,on
R12385	T15230	T15231	arg1Of	ded,t
R12386	T15233	T15231	arg2Of	MA,t
R12387	T15233	T15232	arg1Of	MA,o P
R12388	T15234	T15231	arg3Of	(,t
R12389	T15236	T15235	arg2Of	2 nM) by up-r,16
R12390	T15238	T15236	arg2Of	ating AP,2 nM) by up-r
R12391	T15238	T15237	arg1Of	ating AP,egul
R12392	T15240	T15239	arg1Of	significance,Statistical
R12393	T15240	T15241	arg1Of	significance,from
R12394	T15240	T15244	arg1Of	significance,was
R12395	T15240	T15245	arg2Of	significance,determined
R12396	T15243	T15241	arg2Of	control,from
R12397	T15243	T15242	arg1Of	control,the
R12398	T15245	T15244	arg2Of	determined,was
R12399	T15246	T15245	arg3Of	using,determined
R12400	T15247	T15248	arg2Of	Student,'s
R12401	T15249	T15246	arg2Of	t-test.,using
R12402	T15249	T15248	arg1Of	t-test.,'s
R12403	T15249	T15250	arg1Of	t-test.,(
R12404	T15251	T15250	arg2Of	n,(
R12405	T15251	T15252	arg1Of	n,=
R12406	T15251	T15253	arg1Of	n,4
R12407	T15254	T15250	arg3Of	),(
R12408	T15255	T15256	arg1Of	Controls,were
R12409	T15255	T15258	arg2Of	Controls,set
R12410	T15258	T15256	arg2Of	set,were
R12411	T15258	T15257	arg1Of	set,arbitrarily
R12412	T15258	T15259	arg1Of	set,to
R12413	T15260	T15259	arg2Of	1,to
R12536	T15426	T15425	arg1Of	down-regulation,NF-κB
R12537	T15426	T15427	arg1Of	down-regulation,by
R12538	T15426	T15431	arg1Of	down-regulation,by
R12539	T15426	T15433	arg1Of	down-regulation,killed
R12540	T15428	T15429	arg1Of	PMA,and
R12541	T15429	T15427	arg2Of	and,by
R12542	T15430	T15429	arg2Of	up-regulation,and
R12543	T15432	T15431	arg2Of	heat,by
R12544	T15433	T15437	arg1Of	killed,following
R12545	T15436	T15433	arg2Of	MG1655,killed
R12546	T15436	T15434	arg1Of	MG1655,E.
R12547	T15436	T15435	arg1Of	MG1655,coli
R12548	T15439	T15437	arg2Of	stimulation,following
R12549	T15439	T15438	arg1Of	stimulation,long-term
R12550	T15440	T15441	arg1Of	Transfection,of
R12551	T15440	T15444	arg1Of	Transfection,was
R12552	T15440	T15445	arg2Of	Transfection,performed
R12553	T15443	T15441	arg2Of	T-cells,of
R12554	T15443	T15442	arg1Of	T-cells,Jurkat
R12555	T15445	T15444	arg2Of	performed,was
R12556	T15446	T15445	arg3Of	using,performed
R12557	T15449	T15446	arg2Of	plasmids,using
R12558	T15449	T15447	arg1Of	plasmids,luciferase
R12559	T15449	T15448	arg1Of	plasmids,reporter
R12560	T15449	T15450	arg1Of	plasmids,containing
R12561	T15454	T15453	arg2Of	A,(
R12562	T15455	T15453	arg3Of	),(
R12563	T15457	T15450	arg2Of	stimulation,containing
R12564	T15457	T15451	arg1Of	stimulation,NF-κB
R12565	T15457	T15452	arg1Of	stimulation,cis-elements.
R12566	T15457	T15453	arg1Of	stimulation,(
R12567	T15457	T15456	arg1Of	stimulation,Time-dependent
R12568	T15457	T15458	arg1Of	stimulation,of
R12569	T15460	T15458	arg2Of	T-cells,of
R12570	T15460	T15459	arg1Of	T-cells,Jurkat
R12571	T15460	T15461	arg1Of	T-cells,using
R12572	T15462	T15461	arg2Of	PMA,using
R12573	T15464	T15463	arg1Of	activation,NF-κB
R12574	T15464	T15465	arg1Of	activation,was
R12575	T15464	T15466	arg2Of	activation,evaluated
R12576	T15466	T15465	arg2Of	evaluated,was
R12577	T15466	T15467	modOf	evaluated,using
R12578	T15470	T15468	arg1Of	coli,HK
R12579	T15470	T15469	arg1Of	coli,E.
R12580	T15470	T15471	arg1Of	coli,in
R12581	T15470	T15477	arg1Of	coli,and
R12582	T15474	T15473	arg2Of	B,(
R12583	T15475	T15473	arg3Of	),(
R12584	T15476	T15471	arg2Of	dose-,in
R12585	T15476	T15472	arg1Of	dose-,a
R12586	T15476	T15473	arg1Of	dose-,(
R12587	T15477	T15467	arg2Of	and,using
R12588	T15479	T15478	arg2Of	C,(
R12589	T15480	T15478	arg3Of	),(
R12590	T15482	T15477	arg2Of	manner,and
R12591	T15482	T15478	arg1Of	manner,(
R12592	T15482	T15481	arg1Of	manner,time-dependant
R12593	T15484	T15483	arg1Of	ionophore,Calcium
R12594	T15484	T15485	arg1Of	ionophore,increased
R12595	T15484	T15495	arg1Of	ionophore,resulted
R12596	T15485	T15488	arg1Of	increased,following
R12597	T15485	T15494	arg1Of	increased,and
R12598	T15487	T15485	arg2Of	activity,increased
R12599	T15487	T15486	arg1Of	activity,NF-κB
R12600	T15490	T15488	arg2Of	exposure,following
R12601	T15490	T15489	arg1Of	exposure,PMA
R12602	T15490	T15491	arg1Of	exposure,(
R12603	T15492	T15491	arg2Of	E,(
R12604	T15493	T15491	arg3Of	),(
R12605	T15495	T15494	arg2Of	resulted,and
R12606	T15495	T15496	arg1Of	resulted,in
R12607	T15495	T15500	arg1Of	resulted,in
R12608	T15499	T15496	arg2Of	regulation,in
R12609	T15499	T15497	arg1Of	regulation,a
R12610	T15499	T15498	arg1Of	regulation,negative
R12611	T15501	T15500	arg2Of	response,in
R12612	T15501	T15502	arg1Of	response,to
R12613	T15503	T15502	arg2Of	HK,to
R12614	T15506	T15500	arg3Of	stimulation,in
R12615	T15506	T15504	arg1Of	stimulation,E.
R12616	T15506	T15505	arg1Of	stimulation,coli
R12617	T15506	T15507	arg1Of	stimulation,(
R12618	T15508	T15507	arg2Of	D,(
R12619	T15509	T15507	arg3Of	),(
R12620	T15511	T15510	arg1Of	significance,Statistical
R12621	T15511	T15512	arg1Of	significance,from
R12622	T15511	T15515	arg1Of	significance,was
R12623	T15511	T15516	arg2Of	significance,determined
R12624	T15514	T15512	arg2Of	control,from
R12625	T15514	T15513	arg1Of	control,the
R12626	T15516	T15515	arg2Of	determined,was
R12627	T15517	T15516	arg3Of	using,determined
R12628	T15518	T15519	arg2Of	Student,'s
R12629	T15520	T15517	arg2Of	t-test.,using
R12630	T15520	T15519	arg1Of	t-test.,'s
R12631	T15520	T15521	arg1Of	t-test.,(
R12632	T15522	T15521	arg2Of	n,(
R12633	T15522	T15523	arg1Of	n,=
R12634	T15522	T15524	arg1Of	n,4
R12635	T15525	T15521	arg3Of	),(
R12636	T15526	T15527	arg1Of	Controls,were
R12637	T15526	T15529	arg2Of	Controls,set
R12638	T15529	T15527	arg2Of	set,were
R12639	T15529	T15528	arg1Of	set,arbitrarily
R12640	T15529	T15530	arg1Of	set,to
R12641	T15531	T15530	arg2Of	1,to

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T3063	330-339	NN	denotes	induction
T3068	23-28	NNP	denotes	NF-κB
T3069	29-39	NN	denotes	activation
T3070	40-43	DT	denotes	The
T3071	44-57	NN	denotes	transcription
T3072	58-65	NNS	denotes	factors
T3073	66-71	NNP	denotes	NF-κB
T3074	72-75	CC	denotes	and
T3075	76-80	NNP	denotes	AP-1
T3076	81-85	VBP	denotes	play
T3077	86-89	JJ	denotes	key
T3078	90-95	NNS	denotes	roles
T3079	96-98	IN	denotes	in
T3080	99-102	DT	denotes	the
T3081	103-113	NN	denotes	initiation
T3082	114-116	IN	denotes	of
T3083	117-119	DT	denotes	an
T3084	120-132	JJ	denotes	inflammatory
T3085	133-141	NN	denotes	response
T3086	142-144	IN	denotes	by
T3087	145-153	VBG	denotes	inducing
T3088	154-157	DT	denotes	the
T3089	158-168	NN	denotes	expression
T3090	169-172	CC	denotes	and
T3091	173-182	NN	denotes	secretion
T3092	183-185	IN	denotes	of
T3093	186-196	NNS	denotes	chemokines
T3094	197-200	CC	denotes	and
T3095	201-210	NNS	denotes	cytokines
T3096	211-215	WDT	denotes	that
T3097	216-223	VBP	denotes	attract
T3098	224-227	CC	denotes	and
T3099	228-236	VBP	denotes	activate
T3100	237-243	JJ	denotes	immune
T3101	244-249	NNS	denotes	cells
T3102	249-250	.	denotes	.
T3103	251-258	RB	denotes	However
T3104	258-259	,	denotes	,
T3105	260-263	DT	denotes	the
T3106	264-270	NN	denotes	signal
T3107	271-283	NN	denotes	transduction
T3108	284-292	NNS	denotes	pathways
T3109	293-296	CC	denotes	and
T3110	297-307	JJ	denotes	subsequent
T3111	308-320	JJ	denotes	inflammatory
T3112	321-329	NN	denotes	cytokine
T3113	340-342	IN	denotes	by
T3114	343-348	DT	denotes	these
T3115	349-362	NN	denotes	transcription
T3116	363-370	NNS	denotes	factors
T3117	371-373	VBZ	denotes	is
T3118	374-377	RB	denotes	not
T3119	378-383	RB	denotes	fully
T3120	384-394	VBN	denotes	elucidated
T3121	394-395	.	denotes	.
T3122	396-399	DT	denotes	The
T3123	400-407	JJ	denotes	present
T3124	408-413	NN	denotes	study
T3125	414-416	VBZ	denotes	is
T3126	417-422	VBN	denotes	aimed
T3127	423-425	IN	denotes	at
T3128	426-437	VBG	denotes	determining
T3129	438-441	DT	denotes	the
T3130	442-453	NN	denotes	involvement
T3131	454-456	IN	denotes	of
T3132	457-461	NN	denotes	AP-1
T3133	462-465	CC	denotes	and
T3134	466-471	NN	denotes	NF-κB
T3135	472-474	IN	denotes	in
T3136	475-483	NN	denotes	cytokine
T3137	484-493	NN	denotes	induction
T3138	494-497	CC	denotes	and
T3139	498-508	NN	denotes	regulation
T3140	508-509	.	denotes	.
T3141	510-513	NNP	denotes	PMA
T3142	514-523	NN	denotes	treatment
T3143	524-532	VBD	denotes	resulted
T3144	533-535	IN	denotes	in
T3145	536-538	DT	denotes	an
T3146	539-552	NN	denotes	up-regulation
T3147	553-555	IN	denotes	of
T3148	556-560	NN	denotes	AP-1
T3149	561-566	IN	denotes	after
T3150	567-568	CD	denotes	2
T3151	569-570	NN	denotes	h
T3152	571-579	NN	denotes	exposure
T3153	580-583	CC	denotes	and
T3154	584-593	VBD	denotes	continued
T3155	594-596	TO	denotes	to
T3157	606-616	IN	denotes	throughout
T3158	617-620	DT	denotes	the
T3159	621-629	NN	denotes	analysis
T3160	630-636	NN	denotes	period
T3161	637-638	-LRB-	denotes	(
T3162	638-644	NN	denotes	figure
T3163	645-647	NNS	denotes	1a
T3164	647-648	-RRB-	denotes	)
T3165	648-649	.	denotes	.
T3166	650-652	NNP	denotes	HK
T3167	653-655	NNP	denotes	E.
T3168	656-660	NNS	denotes	coli
T3169	661-670	NN	denotes	treatment
T3170	671-674	VBD	denotes	did
T3171	675-678	RB	denotes	not
T3173	686-690	JJ	denotes	AP-1
T3174	691-701	NN	denotes	activation
T3175	702-704	IN	denotes	in
T3176	705-711	NNP	denotes	Jurkat
T3177	712-719	NNS	denotes	T-cells
T3178	720-721	-LRB-	denotes	(
T3179	721-727	NN	denotes	figure
T3180	728-730	CD	denotes	1b
T3181	730-731	-RRB-	denotes	)
T3182	731-732	.	denotes	.
T3183	733-735	TO	denotes	To
T3184	736-745	VB	denotes	determine
T3185	746-749	DT	denotes	the
T3186	750-761	NN	denotes	involvement
T3187	762-764	IN	denotes	of
T3188	765-775	VBN	denotes	associated
T3189	776-784	NNS	denotes	pathways
T3190	784-785	,	denotes	,
T3191	786-788	PRP	denotes	we
T3192	789-796	VBD	denotes	exposed
T3193	797-802	NNS	denotes	cells
T3194	803-805	TO	denotes	to
T3195	806-809	JJ	denotes	Ca2
T3196	809-810	NN	denotes	+
T3197	811-820	NN	denotes	ionophore
T3198	821-825	IN	denotes	with
T3199	826-828	CC	denotes	or
T3200	829-836	IN	denotes	without
T3201	837-840	NNP	denotes	PMA
T3202	841-844	CC	denotes	and
T3203	845-853	VBD	denotes	observed
T3204	854-855	DT	denotes	a
T3205	856-862	JJ	denotes	modest
T3206	863-874	NN	denotes	involvement
T3207	875-877	IN	denotes	of
T3208	878-881	NNP	denotes	Ca2
T3209	881-882	NNP	denotes	+
T3210	883-885	IN	denotes	in
T3211	886-899	NNP	denotes	PMA-dependent
T3212	900-904	NNP	denotes	AP-1
T3213	905-915	NN	denotes	activation
T3214	916-917	-LRB-	denotes	(
T3215	917-923	NN	denotes	figure
T3216	924-926	CD	denotes	1c
T3217	926-927	-RRB-	denotes	)
T3218	928-933	IN	denotes	while
T3219	934-937	NNP	denotes	Ca2
T3220	937-938	NNP	denotes	+
T3221	939-944	RB	denotes	alone
T3222	945-948	VBD	denotes	did
T3223	949-952	RB	denotes	not
T3224	953-958	VB	denotes	alter
T3225	959-963	JJ	denotes	AP-1
T3226	964-972	NN	denotes	activity
T3227	973-974	-LRB-	denotes	(
T3228	974-978	NNS	denotes	data
T3229	979-982	RB	denotes	not
T3230	983-988	VBN	denotes	shown
T3231	988-989	-RRB-	denotes	)
T3232	989-990	.	denotes	.
T3233	991-1002	RB	denotes	Furthermore
T3234	1002-1003	,	denotes	,
T3235	1004-1008	JJ	denotes	AP-1
T3236	1009-1017	NN	denotes	activity
T3237	1018-1027	VBN	denotes	decreased
T3238	1028-1030	IN	denotes	in
T3239	1031-1032	DT	denotes	a
T3240	1033-1046	JJ	denotes	TCR-deficient
T3241	1047-1053	NNP	denotes	Jurkat
T3242	1054-1058	NN	denotes	cell
T3243	1059-1063	NN	denotes	line
T3244	1064-1068	WRB	denotes	when
T3245	1069-1076	VBN	denotes	exposed
T3246	1077-1079	TO	denotes	to
T3247	1080-1083	NNP	denotes	PMA
T3248	1084-1092	VBN	denotes	compared
T3249	1093-1095	TO	denotes	to
T3250	1096-1099	DT	denotes	the
T3251	1100-1106	NN	denotes	parent
T3252	1107-1111	NN	denotes	cell
T3253	1112-1116	NN	denotes	line
T3254	1117-1127	VBG	denotes	indicating
T3255	1128-1132	IN	denotes	that
T3256	1133-1143	NN	denotes	regulation
T3257	1144-1146	IN	denotes	of
T3258	1147-1151	NN	denotes	AP-1
T3259	1152-1155	VBD	denotes	was
T3260	1156-1160	RB	denotes	only
T3261	1161-1170	RB	denotes	partially
T3262	1171-1177	NN	denotes	T-cell
T3263	1178-1186	NN	denotes	receptor
T3264	1187-1196	JJ	denotes	dependent
T3265	1197-1198	-LRB-	denotes	(
T3266	1198-1204	NN	denotes	figure
T3267	1205-1207	CD	denotes	1d
T3268	1207-1208	-RRB-	denotes	)
T3269	1208-1209	.	denotes	.
T3270	1847-1852	NN	denotes	NF-κB
T3271	1853-1859	NNS	denotes	levels
T3272	1860-1866	VBD	denotes	showed
T3273	1867-1868	DT	denotes	a
T3274	1912-1914	TO	denotes	to
T3275	1869-1878	JJ	denotes	transient
T3276	1879-1887	NN	denotes	increase
T3277	1888-1890	IN	denotes	at
T3278	1891-1892	CD	denotes	1
T3279	1893-1896	NN	denotes	min
T3280	1897-1902	IN	denotes	after
T3281	1903-1911	NN	denotes	exposure
T3282	1915-1918	NNP	denotes	PMA
T3283	1919-1920	-LRB-	denotes	(
T3284	1920-1926	NN	denotes	figure
T3285	1927-1929	NN	denotes	2a
T3286	1929-1930	-RRB-	denotes	)
T3287	1930-1931	.	denotes	.
T3288	1932-1939	RB	denotes	However
T3289	1939-1940	,	denotes	,
T3290	1941-1942	CD	denotes	1
T3291	1943-1944	NN	denotes	h
T3292	1945-1950	IN	denotes	after
T3293	1951-1959	NN	denotes	exposure
T3294	1960-1963	DT	denotes	the
T3295	1964-1969	NN	denotes	NF-κB
T3296	1970-1976	NNS	denotes	levels
T3297	1977-1982	VBD	denotes	began
T3298	1983-1985	TO	denotes	to
T3299	1986-1990	VB	denotes	drop
T3300	1991-1999	VBG	denotes	reaching
T3301	2000-2003	DT	denotes	the
T3302	2004-2010	JJS	denotes	lowest
T3303	2011-2017	NNS	denotes	levels
T3304	2018-2020	IN	denotes	by
T3305	2021-2022	CD	denotes	6
T3306	2023-2024	NN	denotes	h
T3307	2024-2025	,	denotes	,
T3308	2026-2031	IN	denotes	after
T3309	2032-2037	WDT	denotes	which
T3310	2038-2042	PRP	denotes	they
T3311	2043-2052	VBD	denotes	increased
T3312	2053-2058	RB	denotes	again
T3313	2059-2061	IN	denotes	by
T3314	2062-2064	CD	denotes	24
T3315	2065-2067	NN	denotes	h.
T3316	2068-2076	NN	denotes	Exposure
T3317	2077-2079	IN	denotes	of
T3318	2080-2086	NNP	denotes	Jurkat
T3319	2087-2094	NNS	denotes	T-cells
T3320	2095-2097	TO	denotes	to
T3321	2098-2100	NNP	denotes	HK
T3322	2101-2103	NNP	denotes	E.
T3323	2104-2108	NNS	denotes	coli
T3324	2109-2117	VBD	denotes	resulted
T3325	2118-2120	IN	denotes	in
T3326	2121-2122	DT	denotes	a
T3327	2123-2137	JJ	denotes	dose-dependent
T3328	2138-2143	NN	denotes	NF-κB
T3329	2144-2154	NN	denotes	activation
T3330	2154-2155	,	denotes	,
T3331	2156-2160	IN	denotes	with
T3332	2161-2164	DT	denotes	the
T3333	2165-2172	JJS	denotes	highest
T3334	2173-2181	NN	denotes	activity
T3335	2182-2190	VBD	denotes	observed
T3336	2191-2193	IN	denotes	at
T3337	2194-2195	DT	denotes	a
T3338	2196-2204	JJ	denotes	relative
T3339	2205-2218	NN	denotes	concentration
T3340	2219-2221	IN	denotes	of
T3341	2222-2223	CD	denotes	5
T3342	2224-2225	CD	denotes	×
T3343	2226-2229	CD	denotes	107
T3344	2230-2236	NNP	denotes	CFU/ml
T3345	2237-2238	-LRB-	denotes	(
T3346	2238-2244	NN	denotes	figure
T3347	2245-2247	NN	denotes	2b
T3348	2247-2248	-RRB-	denotes	)
T3349	2248-2249	.	denotes	.
T3350	2250-2253	DT	denotes	The
T3351	2254-2268	JJ	denotes	time-dependent
T3353	2280-2282	IN	denotes	of
T3354	2283-2288	NN	denotes	NF-κB
T3355	2289-2291	IN	denotes	by
T3356	2292-2294	NNP	denotes	HK
T3357	2295-2297	NNP	denotes	E.
T3358	2298-2302	NNS	denotes	coli
T3359	2303-2306	VBD	denotes	was
T3360	2307-2315	VBN	denotes	assessed
T3361	2316-2323	RBR	denotes	further
T3362	2324-2329	VBG	denotes	using
T3363	2330-2333	DT	denotes	the
T3364	2334-2341	JJ	denotes	optimal
T3365	2342-2355	NN	denotes	concentration
T3366	2356-2364	VBN	denotes	obtained
T3367	2365-2369	IN	denotes	from
T3368	2370-2376	NN	denotes	figure
T3369	2377-2379	CD	denotes	2b
T3370	2380-2383	CC	denotes	and
T3371	2384-2390	VBD	denotes	showed
T3372	2391-2395	IN	denotes	that
T3373	2396-2399	DT	denotes	the
T3374	2400-2405	JJ	denotes	NF-κB
T3375	2406-2414	NN	denotes	activity
T3376	2415-2424	VBN	denotes	increased
T3377	2425-2430	IN	denotes	after
T3378	2431-2432	CD	denotes	3
T3379	2433-2434	NN	denotes	h
T3380	2435-2437	IN	denotes	of
T3381	2438-2446	NN	denotes	exposure
T3382	2447-2448	-LRB-	denotes	(
T3383	2448-2454	NN	denotes	figure
T3384	2455-2457	JJ	denotes	2c
T3385	2457-2458	-RRB-	denotes	)
T3386	2458-2459	.	denotes	.
T3387	2460-2471	RB	denotes	Furthermore
T3388	2471-2472	,	denotes	,
T3389	2473-2482	VBD	denotes	increased
T3390	2483-2496	JJ	denotes	intracellular
T3391	2497-2500	NNP	denotes	Ca2
T3392	2500-2501	NN	denotes	+
T3393	2502-2510	VBD	denotes	reversed
T3394	2511-2514	DT	denotes	the
T3395	2515-2518	NNP	denotes	PMA
T3396	2519-2528	JJ	denotes	dependent
T3397	2529-2534	NN	denotes	NF-κB
T3398	2535-2545	NN	denotes	inhibition
T3399	2546-2547	-LRB-	denotes	(
T3400	2547-2553	NN	denotes	figure
T3401	2554-2556	CD	denotes	2d
T3402	2556-2557	-RRB-	denotes	)
T3403	2558-2561	CC	denotes	and
T3404	2562-2569	VBD	denotes	reduced
T3405	2570-2573	DT	denotes	the
T3406	2574-2576	NNP	denotes	HK
T3407	2577-2579	NNP	denotes	E.
T3408	2580-2584	NNS	denotes	coli
T3409	2585-2586	:	denotes	-
T3410	2586-2595	JJ	denotes	dependent
T3411	2596-2601	JJ	denotes	NF-κB
T3412	2602-2612	NN	denotes	activation
T3413	2613-2614	-LRB-	denotes	(
T3414	2614-2620	NN	denotes	figure
T3415	2621-2623	CD	denotes	2e
T3416	2623-2624	-RRB-	denotes	)
T3417	2624-2625	.	denotes	.
T15027	1220-1224	CD	denotes	AP-1
T15028	1225-1235	NN	denotes	activation
T15029	1236-1245	VBG	denotes	following
T15030	1246-1255	JJ	denotes	long-term
T15031	1256-1264	NN	denotes	exposure
T15032	1265-1267	IN	denotes	of
T15033	1268-1274	NNP	denotes	Jurkat
T15034	1275-1282	NNS	denotes	T-cells
T15035	1283-1285	TO	denotes	to
T15036	1286-1289	NNP	denotes	PMA
T15037	1289-1290	.	denotes	.
T15038	1291-1297	NNP	denotes	Jurkat
T15039	1298-1305	NNS	denotes	T-cells
T15040	1306-1310	VBD	denotes	were
T15041	1311-1322	VBN	denotes	transfected
T15042	1323-1327	IN	denotes	with
T15043	1328-1338	NN	denotes	luciferase
T15044	1339-1347	NN	denotes	reporter
T15045	1348-1356	NNS	denotes	plasmids
T15046	1357-1367	VBG	denotes	containing
T15047	1368-1371	DT	denotes	the
T15048	1372-1376	NNP	denotes	AP-1
T15049	1377-1389	NNS	denotes	cis-elements
T15050	1389-1390	.	denotes	.
T15051	1391-1392	-LRB-	denotes	(
T15052	1392-1393	NNP	denotes	A
T15053	1393-1394	-RRB-	denotes	)
T15054	1395-1409	JJ	denotes	Time-dependent
T15055	1410-1414	NN	denotes	AP-1
T15056	1415-1425	NN	denotes	activation
T15057	1426-1428	IN	denotes	in
T15058	1429-1437	NN	denotes	response
T15059	1438-1440	TO	denotes	to
T15060	1441-1444	NNP	denotes	PMA
T15061	1444-1445	.	denotes	.
T15062	1446-1447	-LRB-	denotes	(
T15063	1447-1448	NNP	denotes	B
T15064	1448-1449	-RRB-	denotes	)
T15065	1450-1452	NNP	denotes	HK
T15066	1453-1455	NNP	denotes	E.
T15067	1456-1460	NNS	denotes	coli
T15068	1461-1465	VBZ	denotes	does
T15069	1466-1469	RB	denotes	not
T15070	1470-1478	VB	denotes	activate
T15071	1479-1483	NN	denotes	AP-1
T15072	1483-1484	.	denotes	.
T15073	1485-1486	-LRB-	denotes	(
T15074	1486-1487	$	denotes	C
T15075	1487-1488	-RRB-	denotes	)
T15076	1489-1503	JJ	denotes	Dose-dependent
T15077	1504-1514	NN	denotes	activation
T15078	1515-1517	IN	denotes	of
T15079	1518-1522	NN	denotes	AP-1
T15080	1523-1527	VBD	denotes	were
T15081	1528-1537	VBN	denotes	performed
T15082	1538-1543	VBG	denotes	using
T15083	1544-1547	NNP	denotes	PMA
T15084	1548-1553	RB	denotes	alone
T15085	1554-1555	-LRB-	denotes	(
T15086	1555-1559	NN	denotes	grey
T15087	1560-1564	NNS	denotes	bars
T15088	1564-1565	-RRB-	denotes	)
T15089	1566-1569	CC	denotes	and
T15090	1570-1572	IN	denotes	in
T15091	1573-1584	NN	denotes	combination
T15092	1585-1589	IN	denotes	with
T15093	1590-1597	NN	denotes	calcium
T15094	1598-1607	NN	denotes	ionophore
T15095	1608-1609	-LRB-	denotes	(
T15096	1609-1612	NNP	denotes	CaI
T15097	1613-1616	CD	denotes	955
T15098	1617-1619	NNP	denotes	μM
T15099	1619-1620	,	denotes	,
T15100	1621-1626	JJ	denotes	black
T15101	1627-1631	NNS	denotes	bars
T15102	1631-1632	-RRB-	denotes	)
T15103	1632-1633	.	denotes	.
T15104	1634-1635	-LRB-	denotes	(
T15105	1635-1636	NNP	denotes	D
T15106	1636-1637	-RRB-	denotes	)
T15107	1638-1641	SYM	denotes	TCR
T15108	1641-1642	:	denotes	-
T15109	1642-1643	SYM	denotes	/
T15110	1643-1644	:	denotes	-
T15111	1645-1654	NN	denotes	deficient
T15112	1655-1660	NNS	denotes	cells
T15113	1661-1670	VBD	denotes	responded
T15114	1671-1673	TO	denotes	to
T15115	1674-1677	NNP	denotes	PMA
T15116	1678-1679	-LRB-	denotes	(
T15117	1679-1682	CD	denotes	162
T15118	1683-1685	NNP	denotes	nM
T15119	1685-1686	-RRB-	denotes	)
T15120	1687-1689	IN	denotes	by
T15121	1690-1703	JJ	denotes	up-regulating
T15122	1704-1708	NN	denotes	AP-1
T15123	1709-1717	NN	denotes	activity
T15124	1717-1718	.	denotes	.
T15125	1719-1730	NNP	denotes	Statistical
T15126	1731-1743	NN	denotes	significance
T15127	1744-1748	IN	denotes	from
T15128	1749-1752	DT	denotes	the
T15129	1753-1760	NN	denotes	control
T15130	1761-1764	VBD	denotes	was
T15131	1765-1775	VBN	denotes	determined
T15132	1776-1781	VBG	denotes	using
T15133	1782-1789	NN	denotes	Student
T15134	1789-1791	POS	denotes	's
T15135	1792-1798	JJS	denotes	t-test
T15136	1798-1799	.	denotes	.
T15137	1800-1801	-LRB-	denotes	(
T15138	1801-1802	FW	denotes	n
T15139	1803-1804	SYM	denotes	=
T15140	1805-1806	LS	denotes	4
T15141	1806-1807	-RRB-	denotes	)
T15142	1807-1808	.	denotes	.
T15143	1809-1817	NNP	denotes	Controls
T15144	1818-1822	VBD	denotes	were
T15145	1823-1834	RB	denotes	arbitrarily
T15146	1835-1838	VBN	denotes	set
T15147	1839-1841	TO	denotes	to
T15148	1842-1843	CD	denotes	1
T15149	1843-1844	.	denotes	.
T15309	2636-2641	JJ	denotes	NF-κB
T15310	2642-2657	NN	denotes	down-regulation
T15311	2658-2660	IN	denotes	by
T15312	2661-2664	NNP	denotes	PMA
T15313	2665-2668	CC	denotes	and
T15314	2669-2682	JJ	denotes	up-regulation
T15315	2683-2685	IN	denotes	by
T15316	2686-2690	NN	denotes	heat
T15317	2691-2697	VBD	denotes	killed
T15318	2698-2700	NNP	denotes	E.
T15319	2701-2705	NNS	denotes	coli
T15320	2706-2712	NNP	denotes	MG1655
T15321	2713-2722	VBG	denotes	following
T15322	2723-2732	JJ	denotes	long-term
T15323	2733-2744	NN	denotes	stimulation
T15324	2744-2745	.	denotes	.
T15325	2746-2758	NNP	denotes	Transfection
T15326	2759-2761	IN	denotes	of
T15327	2762-2768	NNP	denotes	Jurkat
T15328	2769-2776	NNS	denotes	T-cells
T15329	2777-2780	VBD	denotes	was
T15330	2781-2790	VBN	denotes	performed
T15331	2791-2796	VBG	denotes	using
T15332	2797-2807	NN	denotes	luciferase
T15333	2808-2816	NN	denotes	reporter
T15334	2817-2825	NNS	denotes	plasmids
T15335	2826-2836	VBG	denotes	containing
T15336	2837-2842	JJ	denotes	NF-κB
T15337	2843-2855	NNS	denotes	cis-elements
T15338	2855-2856	.	denotes	.
T15339	2857-2858	-LRB-	denotes	(
T15340	2858-2859	NNP	denotes	A
T15341	2859-2860	-RRB-	denotes	)
T15342	2861-2875	JJ	denotes	Time-dependent
T15343	2876-2887	NN	denotes	stimulation
T15344	2888-2890	IN	denotes	of
T15345	2891-2897	NNP	denotes	Jurkat
T15346	2898-2905	NNS	denotes	T-cells
T15347	2906-2911	VBG	denotes	using
T15348	2912-2915	NNP	denotes	PMA
T15349	2915-2916	.	denotes	.
T15350	2917-2922	JJ	denotes	NF-κB
T15351	2923-2933	NN	denotes	activation
T15352	2934-2937	VBD	denotes	was
T15353	2938-2947	VBN	denotes	evaluated
T15354	2948-2953	VBG	denotes	using
T15355	2954-2956	NNP	denotes	HK
T15356	2957-2959	NNP	denotes	E.
T15357	2960-2964	NNS	denotes	coli
T15358	2965-2967	IN	denotes	in
T15359	2968-2969	DT	denotes	a
T15360	2970-2971	-LRB-	denotes	(
T15361	2971-2972	NNP	denotes	B
T15362	2972-2973	-RRB-	denotes	)
T15363	2974-2978	NN	denotes	dose
T15364	2978-2979	:	denotes	-
T15365	2980-2983	CC	denotes	and
T15366	2984-2985	-LRB-	denotes	(
T15367	2985-2986	NNP	denotes	C
T15368	2986-2987	-RRB-	denotes	)
T15369	2988-3002	JJ	denotes	time-dependant
T15370	3003-3009	NN	denotes	manner
T15371	3009-3010	.	denotes	.
T15372	3011-3018	NN	denotes	Calcium
T15373	3019-3028	NN	denotes	ionophore
T15374	3029-3038	VBD	denotes	increased
T15375	3039-3044	JJ	denotes	NF-κB
T15376	3045-3053	NN	denotes	activity
T15377	3054-3063	VBG	denotes	following
T15378	3064-3067	NNP	denotes	PMA
T15379	3068-3076	NN	denotes	exposure
T15380	3077-3078	-LRB-	denotes	(
T15381	3078-3079	NNP	denotes	E
T15382	3079-3080	-RRB-	denotes	)
T15383	3081-3084	CC	denotes	and
T15384	3085-3093	VBD	denotes	resulted
T15385	3094-3096	IN	denotes	in
T15386	3097-3098	DT	denotes	a
T15387	3099-3107	JJ	denotes	negative
T15388	3108-3118	NN	denotes	regulation
T15389	3119-3121	IN	denotes	in
T15390	3122-3130	NN	denotes	response
T15391	3131-3133	TO	denotes	to
T15392	3134-3136	NNP	denotes	HK
T15393	3137-3139	NNP	denotes	E.
T15394	3140-3144	NNS	denotes	coli
T15395	3145-3156	NN	denotes	stimulation
T15396	3157-3158	-LRB-	denotes	(
T15397	3158-3159	NNP	denotes	D
T15398	3159-3160	-RRB-	denotes	)
T15399	3160-3161	.	denotes	.
T15400	3162-3173	NNP	denotes	Statistical
T15401	3174-3186	NN	denotes	significance
T15402	3187-3191	IN	denotes	from
T15403	3192-3195	DT	denotes	the
T15404	3196-3203	NN	denotes	control
T15405	3204-3207	VBD	denotes	was
T15406	3208-3218	VBN	denotes	determined
T15407	3219-3224	VBG	denotes	using
T15408	3225-3232	NN	denotes	Student
T15409	3232-3234	POS	denotes	's
T15410	3235-3241	JJS	denotes	t-test
T15411	3241-3242	.	denotes	.
T15412	3243-3244	-LRB-	denotes	(
T15413	3244-3245	FW	denotes	n
T15414	3246-3247	SYM	denotes	=
T15415	3248-3249	LS	denotes	4
T15416	3249-3250	-RRB-	denotes	)
T15417	3250-3251	.	denotes	.
T15418	3252-3260	NNP	denotes	Controls
T15419	3261-3265	VBD	denotes	were
T15420	3266-3277	RB	denotes	arbitrarily
T15421	3278-3281	VBN	denotes	set
T15422	3282-3284	TO	denotes	to
T15423	3285-3286	CD	denotes	1
T15424	3286-3287	.	denotes	.
T3156	597-605	VB	denotes	increase
T3172	679-685	VB	denotes	affect
T3352	2269-2279	NN	denotes	activation
R2408	T3063	T3108	conj	induction,pathways
R2415	T3070	T3072	det	The,factors
R2416	T3071	T3072	compound	transcription,factors
R2417	T3072	T3076	nsubj	factors,play
R2418	T3073	T3076	nsubj	NF-κB,play
R2419	T3074	T3073	cc	and,NF-κB
R2420	T3075	T3073	conj	AP-1,NF-κB
R2421	T3076	T3076	ROOT	play,play
R2422	T3077	T3078	amod	key,roles
R2423	T3078	T3076	dobj	roles,play
R2424	T3079	T3076	prep	in,play
R2425	T3080	T3081	det	the,initiation
R2426	T3081	T3079	pobj	initiation,in
R2427	T3082	T3081	prep	of,initiation
R2428	T3083	T3085	det	an,response
R2429	T3084	T3085	amod	inflammatory,response
R2430	T3085	T3082	pobj	response,of
R2431	T3086	T3076	prep	by,play
R2432	T3087	T3086	pcomp	inducing,by
R2433	T3088	T3089	det	the,expression
R2434	T3089	T3087	dobj	expression,inducing
R2435	T3090	T3089	cc	and,expression
R2436	T3091	T3089	conj	secretion,expression
R2437	T3092	T3089	prep	of,expression
R2438	T3093	T3092	pobj	chemokines,of
R2439	T3094	T3093	cc	and,chemokines
R2440	T3095	T3093	conj	cytokines,chemokines
R2441	T3096	T3097	nsubj	that,attract
R2442	T3097	T3095	relcl	attract,cytokines
R2443	T3098	T3097	cc	and,attract
R2444	T3099	T3097	conj	activate,attract
R2445	T3100	T3101	amod	immune,cells
R2446	T3101	T3099	dobj	cells,activate
R2447	T3102	T3076	punct	.,play
R2448	T3103	T3117	advmod	However,is
R2449	T3104	T3117	punct	",",is
R2450	T3105	T3108	det	the,pathways
R2451	T3106	T3108	nmod	signal,pathways
R2452	T3107	T3108	compound	transduction,pathways
R2453	T3108	T3117	nsubj	pathways,is
R2454	T3109	T3108	cc	and,pathways
R2455	T3110	T3063	amod	subsequent,induction
R2456	T3111	T3063	amod	inflammatory,induction
R2457	T3112	T3063	compound	cytokine,induction
R2458	T3113	T3063	prep	by,induction
R2459	T3114	T3116	det	these,factors
R2460	T3115	T3116	compound	transcription,factors
R2461	T3116	T3113	pobj	factors,by
R2462	T3117	T3120	auxpass	is,elucidated
R2463	T3118	T3120	neg	not,elucidated
R2464	T3119	T3120	advmod	fully,elucidated
R2465	T3120	T3120	ROOT	elucidated,elucidated
R2466	T3121	T3120	punct	.,elucidated
R2467	T3122	T3124	det	The,study
R2468	T3123	T3124	amod	present,study
R2469	T3124	T3126	nsubjpass	study,aimed
R2470	T3125	T3126	auxpass	is,aimed
R2471	T3126	T3126	ROOT	aimed,aimed
R2472	T3127	T3126	prep	at,aimed
R2473	T3128	T3127	pcomp	determining,at
R2474	T3129	T3130	det	the,involvement
R2475	T3130	T3128	dobj	involvement,determining
R2476	T3131	T3130	prep	of,involvement
R2477	T3132	T3131	pobj	AP-1,of
R2478	T3133	T3132	cc	and,AP-1
R2479	T3134	T3132	conj	NF-κB,AP-1
R2480	T3135	T3130	prep	in,involvement
R2481	T3136	T3137	compound	cytokine,induction
R2482	T3137	T3135	pobj	induction,in
R2483	T3138	T3137	cc	and,induction
R2484	T3139	T3137	conj	regulation,induction
R2485	T3140	T3126	punct	.,aimed
R2486	T3141	T3142	compound	PMA,treatment
R2487	T3142	T3143	nsubj	treatment,resulted
R2488	T3143	T3143	ROOT	resulted,resulted
R2489	T3144	T3143	prep	in,resulted
R2490	T3145	T3146	det	an,up-regulation
R2491	T3146	T3144	pobj	up-regulation,in
R2492	T3147	T3146	prep	of,up-regulation
R2493	T3148	T3147	pobj	AP-1,of
R2494	T3149	T3143	prep	after,resulted
R2495	T3150	T3152	nummod	2,exposure
R2496	T3151	T3152	compound	h,exposure
R2497	T3152	T3149	pobj	exposure,after
R2498	T3153	T3143	cc	and,resulted
R2499	T3154	T3143	conj	continued,resulted
R2500	T3155	T3156	aux	to,increase
R2501	T3156	T3154	xcomp	increase,continued
R2502	T3157	T3156	prep	throughout,increase
R2503	T3158	T3160	det	the,period
R2504	T3159	T3160	compound	analysis,period
R2505	T3160	T3157	pobj	period,throughout
R2506	T3161	T3160	punct	(,period
R2507	T3162	T3163	compound	figure,1a
R2508	T3163	T3160	appos	1a,period
R2509	T3164	T3160	punct	),period
R2510	T3165	T3143	punct	.,resulted
R2511	T3166	T3169	compound	HK,treatment
R2512	T3167	T3169	compound	E.,treatment
R2513	T3168	T3169	compound	coli,treatment
R2514	T3169	T3172	nsubj	treatment,affect
R2515	T3170	T3172	aux	did,affect
R2516	T3171	T3172	neg	not,affect
R2517	T3172	T3172	ROOT	affect,affect
R2518	T3173	T3174	amod	AP-1,activation
R2519	T3174	T3172	dobj	activation,affect
R2520	T3175	T3174	prep	in,activation
R2521	T3176	T3177	compound	Jurkat,T-cells
R2522	T3177	T3175	pobj	T-cells,in
R2523	T3178	T3179	punct	(,figure
R2524	T3179	T3172	parataxis	figure,affect
R2525	T3180	T3179	nummod	1b,figure
R2526	T3181	T3179	punct	),figure
R2527	T3182	T3172	punct	.,affect
R2528	T3183	T3184	aux	To,determine
R2529	T3184	T3192	advcl	determine,exposed
R2530	T3185	T3186	det	the,involvement
R2531	T3186	T3184	dobj	involvement,determine
R2532	T3187	T3186	prep	of,involvement
R2533	T3188	T3189	amod	associated,pathways
R2534	T3189	T3187	pobj	pathways,of
R2535	T3190	T3192	punct	",",exposed
R2536	T3191	T3192	nsubj	we,exposed
R2537	T3192	T3192	ROOT	exposed,exposed
R2538	T3193	T3192	dobj	cells,exposed
R2539	T3194	T3192	prep	to,exposed
R2540	T3195	T3197	amod	Ca2,ionophore
R2541	T3196	T3197	compound	+,ionophore
R2542	T3197	T3194	pobj	ionophore,to
R2543	T3198	T3192	prep	with,exposed
R2544	T3199	T3198	cc	or,with
R2545	T3200	T3198	conj	without,with
R2546	T3201	T3200	pobj	PMA,without
R2547	T3202	T3192	cc	and,exposed
R2548	T3203	T3192	conj	observed,exposed
R2549	T3204	T3206	det	a,involvement
R2550	T3205	T3206	amod	modest,involvement
R2551	T3206	T3203	dobj	involvement,observed
R2552	T3207	T3206	prep	of,involvement
R2553	T3208	T3209	compound	Ca2,+
R2554	T3209	T3207	pobj	+,of
R2555	T3210	T3209	prep	in,+
R2556	T3211	T3212	compound	PMA-dependent,AP-1
R2557	T3212	T3213	compound	AP-1,activation
R2558	T3213	T3210	pobj	activation,in
R2559	T3214	T3215	punct	(,figure
R2560	T3215	T3209	appos	figure,+
R2561	T3216	T3215	nummod	1c,figure
R2562	T3217	T3209	punct	),+
R2563	T3218	T3224	mark	while,alter
R2564	T3219	T3220	compound	Ca2,+
R2565	T3220	T3224	nsubj	+,alter
R2566	T3221	T3220	advmod	alone,+
R2567	T3222	T3224	aux	did,alter
R2568	T3223	T3224	neg	not,alter
R2569	T3224	T3206	advcl	alter,involvement
R2570	T3225	T3226	amod	AP-1,activity
R2571	T3226	T3224	dobj	activity,alter
R2572	T3227	T3228	punct	(,data
R2573	T3228	T3226	appos	data,activity
R2574	T3229	T3230	neg	not,shown
R2575	T3230	T3228	acl	shown,data
R2576	T3231	T3228	punct	),data
R2577	T3232	T3192	punct	.,exposed
R2578	T3233	T3237	advmod	Furthermore,decreased
R2579	T3234	T3236	punct	",",activity
R2580	T3235	T3236	amod	AP-1,activity
R2581	T3236	T3237	nsubj	activity,decreased
R2582	T3237	T3237	ROOT	decreased,decreased
R2583	T3238	T3237	prep	in,decreased
R2584	T3239	T3243	det	a,line
R2585	T3240	T3243	amod	TCR-deficient,line
R2586	T3241	T3243	compound	Jurkat,line
R2587	T3242	T3243	compound	cell,line
R2588	T3243	T3238	pobj	line,in
R2589	T3244	T3245	advmod	when,exposed
R2590	T3245	T3237	advcl	exposed,decreased
R2591	T3246	T3245	prep	to,exposed
R2592	T3247	T3246	pobj	PMA,to
R2593	T3248	T3237	prep	compared,decreased
R2594	T3249	T3248	prep	to,compared
R2595	T3250	T3253	det	the,line
R2596	T3251	T3252	compound	parent,cell
R2597	T3252	T3253	compound	cell,line
R2598	T3253	T3249	pobj	line,to
R2599	T3254	T3253	acl	indicating,line
R2600	T3255	T3259	mark	that,was
R2601	T3256	T3259	nsubj	regulation,was
R2602	T3257	T3256	prep	of,regulation
R2603	T3258	T3257	pobj	AP-1,of
R2604	T3259	T3254	ccomp	was,indicating
R2605	T3260	T3261	advmod	only,partially
R2606	T3261	T3264	advmod	partially,dependent
R2607	T3262	T3264	nsubj	T-cell,dependent
R2608	T3263	T3264	npadvmod	receptor,dependent
R2609	T3264	T3259	acomp	dependent,was
R2610	T3265	T3266	punct	(,figure
R2611	T3266	T3259	parataxis	figure,was
R2612	T3267	T3266	nummod	1d,figure
R2613	T3268	T3266	punct	),figure
R2614	T3269	T3237	punct	.,decreased
R2615	T3270	T3271	compound	NF-κB,levels
R2616	T3271	T3272	nsubj	levels,showed
R2617	T3272	T3272	ROOT	showed,showed
R2618	T3273	T3276	det	a,increase
R2619	T3274	T3281	prep	to,exposure
R2620	T3275	T3276	amod	transient,increase
R2621	T3276	T3272	dobj	increase,showed
R2622	T3277	T3272	prep	at,showed
R2623	T3278	T3279	nummod	1,min
R2624	T3279	T3277	pobj	min,at
R2625	T3280	T3272	prep	after,showed
R2626	T3281	T3280	pobj	exposure,after
R2627	T3282	T3274	pobj	PMA,to
R2628	T3283	T3285	punct	(,2a
R2629	T3284	T3285	compound	figure,2a
R2630	T3285	T3282	appos	2a,PMA
R2631	T3286	T3272	punct	),showed
R2632	T3287	T3272	punct	.,showed
R2633	T3288	T3297	advmod	However,began
R2634	T3289	T3297	punct	",",began
R2635	T3290	T3291	nummod	1,h
R2636	T3291	T3297	nsubj	h,began
R2637	T3292	T3291	prep	after,h
R2638	T3293	T3292	pobj	exposure,after
R2639	T3294	T3296	det	the,levels
R2640	T3295	T3296	compound	NF-κB,levels
R2641	T3296	T3297	nsubj	levels,began
R2642	T3297	T3297	ROOT	began,began
R2643	T3298	T3299	aux	to,drop
R2644	T3299	T3297	xcomp	drop,began
R2645	T3300	T3299	xcomp	reaching,drop
R2646	T3301	T3303	det	the,levels
R2647	T3302	T3303	amod	lowest,levels
R2648	T3303	T3300	dobj	levels,reaching
R2649	T3304	T3303	prep	by,levels
R2650	T3305	T3306	nummod	6,h
R2651	T3306	T3304	pobj	h,by
R2652	T3307	T3300	punct	",",reaching
R2653	T3308	T3311	prep	after,increased
R2654	T3309	T3308	pobj	which,after
R2655	T3310	T3311	nsubj	they,increased
R2656	T3311	T3297	advcl	increased,began
R2657	T3312	T3311	advmod	again,increased
R2658	T3313	T3311	prep	by,increased
R2659	T3314	T3316	nummod	24,Exposure
R2660	T3315	T3316	compound	h.,Exposure
R2661	T3316	T3313	pobj	Exposure,by
R2662	T3317	T3316	prep	of,Exposure
R2663	T3318	T3319	compound	Jurkat,T-cells
R2664	T3319	T3317	pobj	T-cells,of
R2665	T3320	T3311	prep	to,increased
R2666	T3321	T3323	compound	HK,coli
R2667	T3322	T3323	compound	E.,coli
R2668	T3323	T3320	pobj	coli,to
R2669	T3324	T3311	conj	resulted,increased
R2670	T3325	T3324	prep	in,resulted
R2671	T3326	T3329	det	a,activation
R2672	T3327	T3329	amod	dose-dependent,activation
R2673	T3328	T3329	compound	NF-κB,activation
R2674	T3329	T3325	pobj	activation,in
R2675	T3330	T3324	punct	",",resulted
R2676	T3331	T3324	prep	with,resulted
R2677	T3332	T3334	det	the,activity
R2678	T3333	T3334	amod	highest,activity
R2679	T3334	T3331	pobj	activity,with
R2680	T3335	T3334	acl	observed,activity
R2681	T3336	T3335	prep	at,observed
R2682	T3337	T3339	det	a,concentration
R2683	T3338	T3339	amod	relative,concentration
R2684	T3339	T3336	pobj	concentration,at
R2685	T3340	T3339	prep	of,concentration
R2686	T3341	T3344	nummod	5,CFU/ml
R2687	T3342	T3344	nummod	×,CFU/ml
R2688	T3343	T3344	nummod	107,CFU/ml
R2689	T3344	T3340	pobj	CFU/ml,of
R2690	T3345	T3347	punct	(,2b
R2691	T3346	T3347	compound	figure,2b
R2692	T3347	T3344	appos	2b,CFU/ml
R2693	T3348	T3347	punct	),2b
R2694	T3349	T3297	punct	.,began
R2695	T3350	T3352	det	The,activation
R2696	T3351	T3352	amod	time-dependent,activation
R2697	T3352	T3360	nsubjpass	activation,assessed
R2698	T3353	T3352	prep	of,activation
R2699	T3354	T3353	pobj	NF-κB,of
R2700	T3355	T3352	prep	by,activation
R2701	T3356	T3358	compound	HK,coli
R2702	T3357	T3358	compound	E.,coli
R2703	T3358	T3355	pobj	coli,by
R2704	T3359	T3360	auxpass	was,assessed
R2705	T3360	T3360	ROOT	assessed,assessed
R2706	T3361	T3362	advmod	further,using
R2707	T3362	T3360	advcl	using,assessed
R2708	T3363	T3365	det	the,concentration
R2709	T3364	T3365	amod	optimal,concentration
R2710	T3365	T3362	dobj	concentration,using
R2711	T3366	T3365	acl	obtained,concentration
R2712	T3367	T3366	prep	from,obtained
R2713	T3368	T3367	pobj	figure,from
R2714	T3369	T3368	nummod	2b,figure
R2715	T3370	T3360	cc	and,assessed
R2716	T3371	T3360	conj	showed,assessed
R2717	T3372	T3376	mark	that,increased
R2718	T3373	T3375	det	the,activity
R2719	T3374	T3375	amod	NF-κB,activity
R2720	T3375	T3376	nsubj	activity,increased
R2721	T3376	T3371	ccomp	increased,showed
R2722	T3377	T3376	prep	after,increased
R2723	T3378	T3379	nummod	3,h
R2724	T3379	T3377	pobj	h,after
R2725	T3380	T3379	prep	of,h
R2726	T3381	T3380	pobj	exposure,of
R2727	T3382	T3383	punct	(,figure
R2728	T3383	T3381	appos	figure,exposure
R2729	T3384	T3383	npadvmod	2c,figure
R2730	T3385	T3376	punct	),increased
R2731	T3386	T3360	punct	.,assessed
R2732	T3387	T3393	advmod	Furthermore,reversed
R2733	T3388	T3393	punct	",",reversed
R2734	T3389	T3392	amod	increased,+
R2735	T3390	T3392	compound	intracellular,+
R2736	T3391	T3392	compound	Ca2,+
R2737	T3392	T3393	nsubj	+,reversed
R2738	T3393	T3393	ROOT	reversed,reversed
R2739	T3394	T3395	det	the,PMA
R2740	T3395	T3396	nsubj	PMA,dependent
R2741	T3396	T3398	amod	dependent,inhibition
R2742	T3397	T3398	compound	NF-κB,inhibition
R2743	T3398	T3393	dobj	inhibition,reversed
R2744	T3399	T3400	punct	(,figure
R2745	T3400	T3393	parataxis	figure,reversed
R2746	T3401	T3400	nummod	2d,figure
R2747	T3402	T3400	punct	),figure
R2748	T3403	T3393	cc	and,reversed
R2749	T3404	T3393	conj	reduced,reversed
R2750	T3405	T3412	det	the,activation
R2751	T3406	T3408	compound	HK,coli
R2752	T3407	T3408	compound	E.,coli
R2753	T3408	T3410	npadvmod	coli,dependent
R2754	T3409	T3410	punct	-,dependent
R2755	T3410	T3412	amod	dependent,activation
R2756	T3411	T3412	amod	NF-κB,activation
R2757	T3412	T3404	dobj	activation,reduced
R2758	T3413	T3414	punct	(,figure
R2759	T3414	T3404	npadvmod	figure,reduced
R2760	T3415	T3414	nummod	2e,figure
R2761	T3416	T3414	punct	),figure
R2762	T3417	T3393	punct	.,reversed
R12177	T15027	T15028	nummod	AP-1,activation
R12178	T15028	T15028	ROOT	activation,activation
R12179	T15029	T15028	acl	following,activation
R12180	T15030	T15031	amod	long-term,exposure
R12181	T15031	T15029	pobj	exposure,following
R12182	T15032	T15031	prep	of,exposure
R12183	T15033	T15034	compound	Jurkat,T-cells
R12184	T15034	T15032	pobj	T-cells,of
R12185	T15035	T15031	prep	to,exposure
R12186	T15036	T15035	pobj	PMA,to
R12187	T15037	T15028	punct	.,activation
R12188	T15038	T15039	compound	Jurkat,T-cells
R12189	T15039	T15041	nsubjpass	T-cells,transfected
R12190	T15040	T15041	auxpass	were,transfected
R12191	T15041	T15041	ROOT	transfected,transfected
R12192	T15042	T15041	prep	with,transfected
R12193	T15043	T15044	compound	luciferase,reporter
R12194	T15044	T15045	compound	reporter,plasmids
R12195	T15045	T15042	pobj	plasmids,with
R12196	T15046	T15045	acl	containing,plasmids
R12197	T15047	T15049	det	the,cis-elements
R12198	T15048	T15049	compound	AP-1,cis-elements
R12199	T15049	T15046	dobj	cis-elements,containing
R12200	T15050	T15041	punct	.,transfected
R12201	T15051	T15052	punct	(,A
R12202	T15052	T15052	ROOT	A,A
R12203	T15053	T15052	punct	),A
R12204	T15054	T15056	amod	Time-dependent,activation
R12205	T15055	T15056	compound	AP-1,activation
R12206	T15056	T15056	ROOT	activation,activation
R12207	T15057	T15056	prep	in,activation
R12208	T15058	T15057	pobj	response,in
R12209	T15059	T15058	prep	to,response
R12210	T15060	T15059	pobj	PMA,to
R12211	T15061	T15056	punct	.,activation
R12212	T15062	T15070	punct	(,activate
R12213	T15063	T15067	nmod	B,coli
R12214	T15064	T15067	punct	),coli
R12215	T15065	T15067	compound	HK,coli
R12216	T15066	T15067	compound	E.,coli
R12217	T15067	T15070	nsubj	coli,activate
R12218	T15068	T15070	aux	does,activate
R12219	T15069	T15070	neg	not,activate
R12220	T15070	T15070	ROOT	activate,activate
R12221	T15071	T15070	dobj	AP-1,activate
R12222	T15072	T15070	punct	.,activate
R12223	T15073	T15074	punct	(,C
R12224	T15074	T15077	nmod	C,activation
R12225	T15075	T15074	punct	),C
R12226	T15076	T15077	amod	Dose-dependent,activation
R12227	T15077	T15081	nsubjpass	activation,performed
R12228	T15078	T15077	prep	of,activation
R12229	T15079	T15078	pobj	AP-1,of
R12230	T15080	T15081	auxpass	were,performed
R12231	T15081	T15081	ROOT	performed,performed
R12232	T15082	T15081	advcl	using,performed
R12233	T15083	T15082	dobj	PMA,using
R12234	T15084	T15083	advmod	alone,PMA
R12235	T15085	T15083	punct	(,PMA
R12236	T15086	T15087	amod	grey,bars
R12237	T15087	T15083	appos	bars,PMA
R12238	T15088	T15083	punct	),PMA
R12239	T15089	T15081	cc	and,performed
R12240	T15090	T15081	conj	in,performed
R12241	T15091	T15090	pobj	combination,in
R12242	T15092	T15091	prep	with,combination
R12243	T15093	T15094	compound	calcium,ionophore
R12244	T15094	T15092	pobj	ionophore,with
R12245	T15095	T15094	punct	(,ionophore
R12246	T15096	T15098	nmod	CaI,μM
R12247	T15097	T15098	nummod	955,μM
R12248	T15098	T15094	appos	μM,ionophore
R12249	T15099	T15101	punct	",",bars
R12250	T15100	T15101	amod	black,bars
R12251	T15101	T15098	appos	bars,μM
R12252	T15102	T15098	punct	),μM
R12253	T15103	T15081	punct	.,performed
R12254	T15104	T15105	punct	(,D
R12255	T15105	T15105	ROOT	D,D
R12256	T15106	T15105	punct	),D
R12257	T15107	T15112	amod	TCR,cells
R12258	T15108	T15111	punct	-,deficient
R12259	T15109	T15111	punct	/,deficient
R12260	T15110	T15111	punct	-,deficient
R12261	T15111	T15112	amod	deficient,cells
R12262	T15112	T15113	nsubj	cells,responded
R12263	T15113	T15113	ROOT	responded,responded
R12264	T15114	T15113	prep	to,responded
R12265	T15115	T15114	pobj	PMA,to
R12266	T15116	T15115	punct	(,PMA
R12267	T15117	T15118	nummod	162,nM
R12268	T15118	T15115	appos	nM,PMA
R12269	T15119	T15115	punct	),PMA
R12270	T15120	T15113	prep	by,responded
R12271	T15121	T15123	amod	up-regulating,activity
R12272	T15122	T15123	compound	AP-1,activity
R12273	T15123	T15120	pobj	activity,by
R12274	T15124	T15113	punct	.,responded
R12275	T15125	T15126	compound	Statistical,significance
R12276	T15126	T15131	nsubjpass	significance,determined
R12277	T15127	T15126	prep	from,significance
R12278	T15128	T15129	det	the,control
R12279	T15129	T15127	pobj	control,from
R12280	T15130	T15131	auxpass	was,determined
R12281	T15131	T15131	ROOT	determined,determined
R12282	T15132	T15131	advcl	using,determined
R12283	T15133	T15135	poss	Student,t-test
R12284	T15134	T15133	case	's,Student
R12285	T15135	T15132	dobj	t-test,using
R12286	T15136	T15131	punct	.,determined
R12287	T15137	T15140	punct	(,4
R12288	T15138	T15140	advmod	n,4
R12289	T15139	T15140	punct	=,4
R12290	T15140	T15146	meta	4,set
R12291	T15141	T15140	punct	),4
R12292	T15142	T15140	punct	.,4
R12293	T15143	T15146	nsubjpass	Controls,set
R12294	T15144	T15146	auxpass	were,set
R12295	T15145	T15146	advmod	arbitrarily,set
R12296	T15146	T15146	ROOT	set,set
R12297	T15147	T15146	prep	to,set
R12298	T15148	T15147	pobj	1,to
R12299	T15149	T15146	punct	.,set
R12420	T15309	T15310	amod	NF-κB,down-regulation
R12421	T15310	T15317	nsubj	down-regulation,killed
R12422	T15311	T15310	prep	by,down-regulation
R12423	T15312	T15311	pobj	PMA,by
R12424	T15313	T15312	cc	and,PMA
R12425	T15314	T15312	conj	up-regulation,PMA
R12426	T15315	T15314	agent	by,up-regulation
R12427	T15316	T15315	pobj	heat,by
R12428	T15317	T15317	ROOT	killed,killed
R12429	T15318	T15320	compound	E.,MG1655
R12430	T15319	T15320	compound	coli,MG1655
R12431	T15320	T15317	dobj	MG1655,killed
R12432	T15321	T15317	prep	following,killed
R12433	T15322	T15323	amod	long-term,stimulation
R12434	T15323	T15321	pobj	stimulation,following
R12435	T15324	T15317	punct	.,killed
R12436	T15325	T15330	nsubjpass	Transfection,performed
R12437	T15326	T15325	prep	of,Transfection
R12438	T15327	T15328	compound	Jurkat,T-cells
R12439	T15328	T15326	pobj	T-cells,of
R12440	T15329	T15330	auxpass	was,performed
R12441	T15330	T15330	ROOT	performed,performed
R12442	T15331	T15330	advcl	using,performed
R12443	T15332	T15333	compound	luciferase,reporter
R12444	T15333	T15334	compound	reporter,plasmids
R12445	T15334	T15331	dobj	plasmids,using
R12446	T15335	T15334	acl	containing,plasmids
R12447	T15336	T15337	amod	NF-κB,cis-elements
R12448	T15337	T15335	dobj	cis-elements,containing
R12449	T15338	T15330	punct	.,performed
R12450	T15339	T15340	punct	(,A
R12451	T15340	T15340	ROOT	A,A
R12452	T15341	T15340	punct	),A
R12453	T15342	T15343	amod	Time-dependent,stimulation
R12454	T15343	T15343	ROOT	stimulation,stimulation
R12455	T15344	T15343	prep	of,stimulation
R12456	T15345	T15346	compound	Jurkat,T-cells
R12457	T15346	T15344	pobj	T-cells,of
R12458	T15347	T15343	acl	using,stimulation
R12459	T15348	T15347	dobj	PMA,using
R12460	T15349	T15343	punct	.,stimulation
R12461	T15350	T15351	amod	NF-κB,activation
R12462	T15351	T15353	nsubjpass	activation,evaluated
R12463	T15352	T15353	auxpass	was,evaluated
R12464	T15353	T15353	ROOT	evaluated,evaluated
R12465	T15354	T15353	advcl	using,evaluated
R12466	T15355	T15357	compound	HK,coli
R12467	T15356	T15357	compound	E.,coli
R12468	T15357	T15354	dobj	coli,using
R12469	T15358	T15354	prep	in,using
R12470	T15359	T15370	det	a,manner
R12471	T15360	T15363	punct	(,dose
R12472	T15361	T15363	nmod	B,dose
R12473	T15362	T15363	punct	),dose
R12474	T15363	T15370	nmod	dose,manner
R12475	T15364	T15363	punct	-,dose
R12476	T15365	T15363	cc	and,dose
R12477	T15366	T15363	punct	(,dose
R12478	T15367	T15370	nmod	C,manner
R12479	T15368	T15370	punct	),manner
R12480	T15369	T15370	amod	time-dependant,manner
R12481	T15370	T15358	pobj	manner,in
R12482	T15371	T15353	punct	.,evaluated
R12483	T15372	T15373	compound	Calcium,ionophore
R12484	T15373	T15374	nsubj	ionophore,increased
R12485	T15374	T15374	ROOT	increased,increased
R12486	T15375	T15376	amod	NF-κB,activity
R12487	T15376	T15374	dobj	activity,increased
R12488	T15377	T15374	prep	following,increased
R12489	T15378	T15379	compound	PMA,exposure
R12490	T15379	T15377	pobj	exposure,following
R12491	T15380	T15381	punct	(,E
R12492	T15381	T15379	npadvmod	E,exposure
R12493	T15382	T15374	punct	),increased
R12494	T15383	T15374	cc	and,increased
R12495	T15384	T15374	conj	resulted,increased
R12496	T15385	T15384	prep	in,resulted
R12497	T15386	T15388	det	a,regulation
R12498	T15387	T15388	amod	negative,regulation
R12499	T15388	T15385	pobj	regulation,in
R12500	T15389	T15388	prep	in,regulation
R12501	T15390	T15389	pobj	response,in
R12502	T15391	T15390	prep	to,response
R12503	T15392	T15395	compound	HK,stimulation
R12504	T15393	T15395	compound	E.,stimulation
R12505	T15394	T15395	compound	coli,stimulation
R12506	T15395	T15391	pobj	stimulation,to
R12507	T15396	T15397	punct	(,D
R12508	T15397	T15395	appos	D,stimulation
R12509	T15398	T15374	punct	),increased
R12510	T15399	T15374	punct	.,increased
R12511	T15400	T15401	compound	Statistical,significance
R12512	T15401	T15406	nsubjpass	significance,determined
R12513	T15402	T15401	prep	from,significance
R12514	T15403	T15404	det	the,control
R12515	T15404	T15402	pobj	control,from
R12516	T15405	T15406	auxpass	was,determined
R12517	T15406	T15406	ROOT	determined,determined
R12518	T15407	T15406	advcl	using,determined
R12519	T15408	T15410	poss	Student,t-test
R12520	T15409	T15408	case	's,Student
R12521	T15410	T15407	dobj	t-test,using
R12522	T15411	T15406	punct	.,determined
R12523	T15412	T15415	punct	(,4
R12524	T15413	T15415	advmod	n,4
R12525	T15414	T15415	punct	=,4
R12526	T15415	T15421	meta	4,set
R12527	T15416	T15415	punct	),4
R12528	T15417	T15415	punct	.,4
R12529	T15418	T15421	nsubjpass	Controls,set
R12530	T15419	T15421	auxpass	were,set
R12531	T15420	T15421	advmod	arbitrarily,set
R12532	T15421	T15421	ROOT	set,set
R12533	T15422	T15421	prep	to,set
R12534	T15423	T15422	pobj	1,to
R12535	T15424	T15421	punct	.,set

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T3782	498-508	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T3783	542-552	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T3784	1133-1143	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T3785	44-57	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T3786	349-362	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T3787	120-141	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory response
T3788	173-182	http://purl.obolibrary.org/obo/GO_0046903	denotes	secretion
T3789	173-196	http://purl.obolibrary.org/obo/GO_0090195	denotes	secretion of chemokines
T3790	228-249	http://purl.obolibrary.org/obo/GO_1902107	denotes	activate immune cells
T3791	228-249	http://purl.obolibrary.org/obo/GO_0045321	denotes	activate immune cells
T3792	228-249	http://purl.obolibrary.org/obo/GO_0002694	denotes	activate immune cells
T3793	264-270	http://purl.obolibrary.org/obo/GO_0023052	denotes	signal
T3794	264-283	http://purl.obolibrary.org/obo/GO_0007165	denotes	signal transduction
T3795	264-292	http://purl.obolibrary.org/obo/GO_0036498	denotes	signal transduction pathways
T3796	264-292	http://purl.obolibrary.org/obo/GO_0036500	denotes	signal transduction pathways
T3797	264-292	http://purl.obolibrary.org/obo/GO_0036499	denotes	signal transduction pathways
T3798	264-292	http://purl.obolibrary.org/obo/GO_0035556	denotes	signal transduction pathways
T3799	271-283	http://purl.obolibrary.org/obo/GO_0009293	denotes	transduction
T3800	321-339	http://purl.obolibrary.org/obo/GO_0042089	denotes	cytokine induction
T3801	475-493	http://purl.obolibrary.org/obo/GO_0042089	denotes	cytokine induction
T3802	811-820	http://purl.obolibrary.org/obo/GO_0022809	denotes	ionophore
T3803	1033-1036	http://purl.obolibrary.org/obo/GO_0006283	denotes	TCR
T3804	2269-2288	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of NF-κB
T15272	1429-1444	http://purl.obolibrary.org/obo/GO_1904627	denotes	response to PMA
T15273	1598-1607	http://purl.obolibrary.org/obo/GO_0022809	denotes	ionophore
T15274	1638-1641	http://purl.obolibrary.org/obo/GO_0006283	denotes	TCR
T15539	2647-2657	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T15540	2672-2682	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T15541	3108-3118	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T15542	2917-2933	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T15543	3019-3028	http://purl.obolibrary.org/obo/GO_0022809	denotes	ionophore
T15544	3099-3130	http://purl.obolibrary.org/obo/GO_1901032	denotes	negative regulation in response
T15545	3099-3130	http://purl.obolibrary.org/obo/GO_1901458	denotes	negative regulation in response
T15546	3099-3130	http://purl.obolibrary.org/obo/GO_0031348	denotes	negative regulation in response
T15547	3099-3130	http://purl.obolibrary.org/obo/GO_0050728	denotes	negative regulation in response
T15548	3099-3130	http://purl.obolibrary.org/obo/GO_0048585	denotes	negative regulation in response
T15549	3099-3130	http://purl.obolibrary.org/obo/GO_1901420	denotes	negative regulation in response
T15550	3099-3130	http://purl.obolibrary.org/obo/GO_1901443	denotes	negative regulation in response
T15551	3099-3130	http://purl.obolibrary.org/obo/GO_0050777	denotes	negative regulation in response
T15552	3099-3130	http://purl.obolibrary.org/obo/GO_0050687	denotes	negative regulation in response

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T3805	811-820	http://purl.obolibrary.org/obo/GO_0022809	denotes	ionophore
T15275	1598-1607	http://purl.obolibrary.org/obo/GO_0022809	denotes	ionophore
T15553	3019-3028	http://purl.obolibrary.org/obo/GO_0022809	denotes	ionophore

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T3806	244-249	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T15554	2771-2776	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T15555	2900-2905	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3807	714-719	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3808	797-802	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3809	2089-2094	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3810	1033-1036	http://purl.obolibrary.org/obo/GO_0042101	denotes	TCR
T3811	2483-2496	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T15276	1277-1282	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T15277	1300-1305	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T15278	1655-1660	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T15279	1638-1641	http://purl.obolibrary.org/obo/GO_0042101	denotes	TCR

sentences

Id	Subject	Object	Predicate	Lexical cue
T3051	40-250	Sentence	denotes	The transcription factors NF-κB and AP-1 play key roles in the initiation of an inflammatory response by inducing the expression and secretion of chemokines and cytokines that attract and activate immune cells.
T3052	251-395	Sentence	denotes	However, the signal transduction pathways and subsequent inflammatory cytokine induction by these transcription factors is not fully elucidated.
T3053	396-509	Sentence	denotes	The present study is aimed at determining the involvement of AP-1 and NF-κB in cytokine induction and regulation.
T3054	510-649	Sentence	denotes	PMA treatment resulted in an up-regulation of AP-1 after 2 h exposure and continued to increase throughout the analysis period (figure 1a).
T3055	650-732	Sentence	denotes	HK E. coli treatment did not affect AP-1 activation in Jurkat T-cells (figure 1b).
T3056	733-990	Sentence	denotes	To determine the involvement of associated pathways, we exposed cells to Ca2+ ionophore with or without PMA and observed a modest involvement of Ca2+ in PMA-dependent AP-1 activation (figure 1c) while Ca2+ alone did not alter AP-1 activity (data not shown).
T3057	991-1209	Sentence	denotes	Furthermore, AP-1 activity decreased in a TCR-deficient Jurkat cell line when exposed to PMA compared to the parent cell line indicating that regulation of AP-1 was only partially T-cell receptor dependent (figure 1d).
T3058	1847-1931	Sentence	denotes	NF-κB levels showed a transient increase at 1 min after exposure to PMA (figure 2a).
T3059	1932-2067	Sentence	denotes	However, 1 h after exposure the NF-κB levels began to drop reaching the lowest levels by 6 h, after which they increased again by 24 h.
T3060	2068-2249	Sentence	denotes	Exposure of Jurkat T-cells to HK E. coli resulted in a dose-dependent NF-κB activation, with the highest activity observed at a relative concentration of 5 × 107 CFU/ml (figure 2b).
T3061	2250-2459	Sentence	denotes	The time-dependent activation of NF-κB by HK E. coli was assessed further using the optimal concentration obtained from figure 2b and showed that the NF-κB activity increased after 3 h of exposure (figure 2c).
T3062	2460-2625	Sentence	denotes	Furthermore, increased intracellular Ca2+ reversed the PMA dependent NF-κB inhibition (figure 2d) and reduced the HK E. coli -dependent NF-κB activation (figure 2e).
T15023	1220-1290	Sentence	denotes	AP-1 activation following long-term exposure of Jurkat T-cells to PMA.
T15024	1291-1718	Sentence	denotes	Jurkat T-cells were transfected with luciferase reporter plasmids containing the AP-1 cis-elements. (A) Time-dependent AP-1 activation in response to PMA. (B) HK E. coli does not activate AP-1. (C) Dose-dependent activation of AP-1 were performed using PMA alone (grey bars) and in combination with calcium ionophore (CaI 955 μM, black bars). (D) TCR-/- deficient cells responded to PMA (162 nM) by up-regulating AP-1 activity.
T15025	1719-1808	Sentence	denotes	Statistical significance from the control was determined using Student's t-test. (n = 4).
T15026	1809-1844	Sentence	denotes	Controls were arbitrarily set to 1.
T15303	2636-2745	Sentence	denotes	NF-κB down-regulation by PMA and up-regulation by heat killed E. coli MG1655 following long-term stimulation.
T15304	2746-2916	Sentence	denotes	Transfection of Jurkat T-cells was performed using luciferase reporter plasmids containing NF-κB cis-elements. (A) Time-dependent stimulation of Jurkat T-cells using PMA.
T15305	2917-3010	Sentence	denotes	NF-κB activation was evaluated using HK E. coli in a (B) dose- and (C) time-dependant manner.
T15306	3011-3161	Sentence	denotes	Calcium ionophore increased NF-κB activity following PMA exposure (E) and resulted in a negative regulation in response to HK E. coli stimulation (D).
T15307	3162-3251	Sentence	denotes	Statistical significance from the control was determined using Student's t-test. (n = 4).
T15308	3252-3287	Sentence	denotes	Controls were arbitrarily set to 1.
T38	0-39	Sentence	denotes	Regulation of AP-1 and NF-κB activation
T39	40-250	Sentence	denotes	The transcription factors NF-κB and AP-1 play key roles in the initiation of an inflammatory response by inducing the expression and secretion of chemokines and cytokines that attract and activate immune cells.
T40	251-395	Sentence	denotes	However, the signal transduction pathways and subsequent inflammatory cytokine induction by these transcription factors is not fully elucidated.
T41	396-509	Sentence	denotes	The present study is aimed at determining the involvement of AP-1 and NF-κB in cytokine induction and regulation.
T42	510-649	Sentence	denotes	PMA treatment resulted in an up-regulation of AP-1 after 2 h exposure and continued to increase throughout the analysis period (figure 1a).
T43	650-732	Sentence	denotes	HK E. coli treatment did not affect AP-1 activation in Jurkat T-cells (figure 1b).
T44	733-990	Sentence	denotes	To determine the involvement of associated pathways, we exposed cells to Ca2+ ionophore with or without PMA and observed a modest involvement of Ca2+ in PMA-dependent AP-1 activation (figure 1c) while Ca2+ alone did not alter AP-1 activity (data not shown).
T45	991-1209	Sentence	denotes	Furthermore, AP-1 activity decreased in a TCR-deficient Jurkat cell line when exposed to PMA compared to the parent cell line indicating that regulation of AP-1 was only partially T-cell receptor dependent (figure 1d).
T46	1210-1290	Sentence	denotes	Figure 1 AP-1 activation following long-term exposure of Jurkat T-cells to PMA.
T47	1291-1718	Sentence	denotes	Jurkat T-cells were transfected with luciferase reporter plasmids containing the AP-1 cis-elements. (A) Time-dependent AP-1 activation in response to PMA. (B) HK E. coli does not activate AP-1. (C) Dose-dependent activation of AP-1 were performed using PMA alone (grey bars) and in combination with calcium ionophore (CaI 955 μM, black bars). (D) TCR-/- deficient cells responded to PMA (162 nM) by up-regulating AP-1 activity.
T48	1719-1808	Sentence	denotes	Statistical significance from the control was determined using Student's t-test. (n = 4).
T49	1809-1844	Sentence	denotes	Controls were arbitrarily set to 1.
T50	1847-1931	Sentence	denotes	NF-κB levels showed a transient increase at 1 min after exposure to PMA (figure 2a).
T51	1932-2067	Sentence	denotes	However, 1 h after exposure the NF-κB levels began to drop reaching the lowest levels by 6 h, after which they increased again by 24 h.
T52	2068-2249	Sentence	denotes	Exposure of Jurkat T-cells to HK E. coli resulted in a dose-dependent NF-κB activation, with the highest activity observed at a relative concentration of 5 × 107 CFU/ml (figure 2b).
T53	2250-2459	Sentence	denotes	The time-dependent activation of NF-κB by HK E. coli was assessed further using the optimal concentration obtained from figure 2b and showed that the NF-κB activity increased after 3 h of exposure (figure 2c).
T54	2460-2625	Sentence	denotes	Furthermore, increased intracellular Ca2+ reversed the PMA dependent NF-κB inhibition (figure 2d) and reduced the HK E. coli -dependent NF-κB activation (figure 2e).
T55	2626-2745	Sentence	denotes	Figure 2 NF-κB down-regulation by PMA and up-regulation by heat killed E. coli MG1655 following long-term stimulation.
T56	2746-2916	Sentence	denotes	Transfection of Jurkat T-cells was performed using luciferase reporter plasmids containing NF-κB cis-elements. (A) Time-dependent stimulation of Jurkat T-cells using PMA.
T57	2917-3010	Sentence	denotes	NF-κB activation was evaluated using HK E. coli in a (B) dose- and (C) time-dependant manner.
T58	3011-3161	Sentence	denotes	Calcium ionophore increased NF-κB activity following PMA exposure (E) and resulted in a negative regulation in response to HK E. coli stimulation (D).
T59	3162-3251	Sentence	denotes	Statistical significance from the control was determined using Student's t-test. (n = 4).
T60	3252-3287	Sentence	denotes	Controls were arbitrarily set to 1.

events-check-again

Id	Subject	Object	Predicate	Lexical cue
T15286	1328-1338	Protein	denotes	luciferase
T15561	2797-2807	Protein	denotes	luciferase

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T3813	23-28	Protein	denotes	NF-κB
T3814	29-39	Positive_regulation	denotes	activation
T3815	29-39	Positive_regulation	denotes	activation
T3818	29-39	Positive_regulation	denotes	activation
T3819	29-39	Positive_regulation	denotes	activation
T3820	66-71	Protein	denotes	NF-κB
T3821	76-80	Protein	denotes	AP-1
T3822	173-182	Localization	denotes	secretion
T3823	173-182	Localization	denotes	secretion
T3824	145-153	Positive_regulation	denotes	inducing
T3825	145-153	Positive_regulation	denotes	inducing
T3826	145-153	Positive_regulation	denotes	inducing
T3827	145-153	Positive_regulation	denotes	inducing
T3828	145-153	Positive_regulation	denotes	inducing
T3829	145-153	Positive_regulation	denotes	inducing
T3831	466-471	Protein	denotes	NF-κB
T3832	498-508	Regulation	denotes	regulation
T3833	498-508	Regulation	denotes	regulation
T3834	686-690	Protein	denotes	AP-1
T3835	691-701	Positive_regulation	denotes	activation
T3836	679-685	Regulation	denotes	affect
T3837	959-963	Protein	denotes	AP-1
T3838	1004-1008	Protein	denotes	AP-1
T3839	1033-1036	Protein	denotes	TCR
T3840	1147-1151	Protein	denotes	AP-1
T3841	1018-1027	Negative_regulation	denotes	decreased
T3842	1037-1046	Negative_regulation	denotes	deficient
T3843	1133-1143	Regulation	denotes	regulation
T3844	1847-1852	Protein	denotes	NF-κB
T3845	1879-1887	Positive_regulation	denotes	increase
T3846	1964-1969	Protein	denotes	NF-κB
T3847	2098-2102	Protein	denotes	HK E
T3848	2138-2143	Protein	denotes	NF-κB
T3849	2144-2154	Positive_regulation	denotes	activation
T3850	2283-2288	Protein	denotes	NF-κB
T3851	2292-2302	Protein	denotes	HK E. coli
T3852	2400-2405	Protein	denotes	NF-κB
T3853	2269-2279	Positive_regulation	denotes	activation
T3854	2415-2424	Positive_regulation	denotes	increased
T3855	2515-2534	Protein	denotes	PMA dependent NF-κB
T3856	2574-2601	Protein	denotes	HK E. coli -dependent NF-κB
T3857	2535-2545	Negative_regulation	denotes	inhibition
T3858	2602-2612	Positive_regulation	denotes	activation
T3859	2562-2569	Negative_regulation	denotes	reduced
T15287	1220-1224	Protein	denotes	AP-1
T15288	1225-1235	Positive_regulation	denotes	activation
T15289	1328-1338	Protein	denotes	luciferase
T15290	1372-1376	Protein	denotes	AP-1
T15291	1410-1414	Protein	denotes	AP-1
T15292	1415-1425	Positive_regulation	denotes	activation
T15293	1479-1483	Protein	denotes	AP-1
T15294	1470-1478	Positive_regulation	denotes	activate
T15295	1518-1522	Protein	denotes	AP-1
T15296	1609-1619	Protein	denotes	CaI 955 μM
T15297	1504-1514	Positive_regulation	denotes	activation
T15298	1704-1708	Protein	denotes	AP-1
T15299	1690-1703	Positive_regulation	denotes	up-regulating
T15562	2636-2641	Protein	denotes	NF-κB
T15563	2642-2657	Negative_regulation	denotes	down-regulation
T15564	2669-2682	Positive_regulation	denotes	up-regulation
T15565	2642-2657	Negative_regulation	denotes	down-regulation
T15566	2797-2807	Protein	denotes	luciferase
T15567	2837-2842	Protein	denotes	NF-κB
T15568	2917-2922	Protein	denotes	NF-κB
T15569	2923-2933	Positive_regulation	denotes	activation
T15570	3039-3044	Protein	denotes	NF-κB
T15571	3134-3136	Protein	denotes	HK
T15572	3029-3038	Positive_regulation	denotes	increased
T3830	457-461	Protein	denotes	AP-1
R3109	T3813	T3815	themeOf	NF-κB,activation
R3114	T3820	T3822	themeOf	NF-κB,secretion
R3115	T3820	T3826	causeOf	NF-κB,inducing
R3117	T3821	T3823	themeOf	AP-1,secretion
R3120	T3822	T3824	themeOf	secretion,inducing
R3123	T3823	T3825	themeOf	secretion,inducing
R3135	T3850	T3853	themeOf	NF-κB,activation
R3136	T3851	T3853	causeOf	HK E. coli,activation
R3137	T3852	T3854	themeOf	NF-κB,increased
R3138	T3855	T3857	themeOf	PMA dependent NF-κB,inhibition
R3139	T3856	T3858	themeOf	HK E. coli -dependent NF-κB,activation
R3140	T3858	T3859	themeOf	activation,reduced
R12415	T15287	T15288	themeOf	AP-1,activation
R12416	T15291	T15292	themeOf	AP-1,activation
R12417	T15293	T15294	themeOf	AP-1,activate
R12418	T15295	T15297	themeOf	AP-1,activation
R12419	T15298	T15299	themeOf	AP-1,up-regulating
R12642	T15562	T15563	themeOf	NF-κB,down-regulation
R12643	T15563	T15564	themeOf	down-regulation,up-regulation
R12644	T15564	T15565	themeOf	up-regulation,down-regulation
R12645	T15568	T15569	themeOf	NF-κB,activation
R12646	T15570	T15572	themeOf	NF-κB,increased
R3116	T3820	T3827	causeOf	NF-κB,inducing
R3118	T3821	T3828	causeOf	AP-1,inducing
R3119	T3821	T3829	causeOf	AP-1,inducing
R3121	T3822	T3826	themeOf	secretion,inducing
R3122	T3822	T3828	themeOf	secretion,inducing
R3124	T3823	T3827	themeOf	secretion,inducing
R3125	T3823	T3829	themeOf	secretion,inducing
R3126	T3830	T3832	themeOf	AP-1,regulation
R3127	T3831	T3833	themeOf	NF-κB,regulation
R3128	T3834	T3835	themeOf	AP-1,activation
R3129	T3835	T3836	themeOf	activation,affect
R3130	T3838	T3841	themeOf	AP-1,decreased
R3131	T3839	T3842	themeOf	TCR,deficient
R3132	T3840	T3843	themeOf	AP-1,regulation
R3133	T3844	T3845	themeOf	NF-κB,increase
R3134	T3848	T3849	themeOf	NF-κB,activation

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue
T15022	1328-1338	Protein	denotes	luciferase
T15302	2797-2807	Protein	denotes	luciferase

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T3758	76-80	P05412	denotes	AP-1
T3759	417-422	P26358	denotes	aimed
T3760	457-461	P05412	denotes	AP-1
T3761	556-560	P05412	denotes	AP-1
T3762	686-690	P05412	denotes	AP-1
T3763	900-904	P05412	denotes	AP-1
T3764	959-963	P05412	denotes	AP-1
T3765	1004-1008	P05412	denotes	AP-1
T3766	1147-1151	P05412	denotes	AP-1
T3767	2196-2204	Q04864	denotes	relative
T15261	1220-1224	P05412	denotes	AP-1
T15262	1328-1338	P08659	denotes	luciferase
T15263	1372-1376	P05412	denotes	AP-1
T15264	1410-1414	P05412	denotes	AP-1
T15265	1479-1483	P05412	denotes	AP-1
T15266	1518-1522	P05412	denotes	AP-1
T15267	1704-1708	P05412	denotes	AP-1
T15532	2797-2807	P08659	denotes	luciferase

test2

Id	Subject	Object	Predicate	Lexical cue
T15021	1328-1338	Protein	denotes	luciferase
T15301	2797-2807	Protein	denotes	luciferase

PMC:2889865 / 5341-8631 JSONTXT

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PMC:2889865 / 5341-8631 JSON TXT