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PMC:2889865 / 5332-16309 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T3422 32-37 NN denotes NF-κB
T3423 38-48 NN denotes activation
T3424 49-52 DT denotes The
T3425 53-66 NN denotes transcription
T3426 67-74 NN denotes factors
T3427 75-80 NN denotes NF-κB
T3428 81-84 CC denotes and
T3429 85-89 NN denotes AP-1
T3430 90-94 VB denotes play
T3431 95-98 JJ denotes key
T3432 99-104 NN denotes roles
T3433 105-107 IN denotes in
T3434 108-111 DT denotes the
T3435 112-122 NN denotes initiation
T3436 123-125 IN denotes of
T3437 126-128 DT denotes an
T3438 129-141 JJ denotes inflammatory
T3439 142-150 NN denotes response
T3440 151-153 IN denotes by
T3441 154-162 VB denotes inducing
T3442 163-166 DT denotes the
T3443 167-177 NN denotes expression
T3444 178-181 CC denotes and
T3445 182-191 NN denotes secretion
T3446 192-194 IN denotes of
T3447 195-205 NN denotes chemokines
T3448 206-209 CC denotes and
T3449 210-219 NN denotes cytokines
T3450 220-224 WDT denotes that
T3451 225-232 VB denotes attract
T3452 233-236 CC denotes and
T3453 237-245 VB denotes activate
T3454 246-252 JJ denotes immune
T3455 253-258 NN denotes cells
T3456 260-267 RB denotes However
T3457 267-268 -COMMA- denotes ,
T3458 269-272 DT denotes the
T3459 273-279 NN denotes signal
T3460 280-292 NN denotes transduction
T3461 293-301 NN denotes pathways
T3462 302-305 CC denotes and
T3463 306-316 JJ denotes subsequent
T3464 317-329 JJ denotes inflammatory
T3465 330-338 NN denotes cytokine
T3466 339-348 NN denotes induction
T3467 349-351 IN denotes by
T3468 352-357 DT denotes these
T3469 358-371 NN denotes transcription
T3470 372-379 NN denotes factors
T3471 380-382 VB denotes is
T3472 383-386 RB denotes not
T3473 387-392 RB denotes fully
T3474 393-403 VB denotes elucidated
T3475 405-408 DT denotes The
T3476 409-416 JJ denotes present
T3477 417-422 NN denotes study
T3478 423-425 VB denotes is
T3479 426-431 VB denotes aimed
T3480 432-434 IN denotes at
T3481 435-446 VB denotes determining
T3482 447-450 DT denotes the
T3483 451-462 NN denotes involvement
T3484 463-465 IN denotes of
T3485 466-470 NN denotes AP-1
T3486 471-474 CC denotes and
T3487 475-480 NN denotes NF-κB
T3488 481-483 IN denotes in
T3489 484-492 NN denotes cytokine
T3490 493-502 NN denotes induction
T3491 503-506 CC denotes and
T3492 507-517 NN denotes regulation
T3493 519-522 NN denotes PMA
T3494 523-532 NN denotes treatment
T3495 533-541 VB denotes resulted
T3496 542-544 IN denotes in
T3497 545-547 DT denotes an
T3498 548-561 NN denotes up-regulation
T3499 562-564 IN denotes of
T3500 565-569 NN denotes AP-1
T3501 570-575 IN denotes after
T3502 576-577 CD denotes 2
T3503 578-579 NN denotes h
T3504 580-588 NN denotes exposure
T3505 589-592 CC denotes and
T3506 593-602 VB denotes continued
T3507 603-605 TO denotes to
T3508 606-614 VB denotes increase
T3509 615-625 IN denotes throughout
T3510 626-629 DT denotes the
T3511 630-638 NN denotes analysis
T3512 639-645 NN denotes period
T3513 646-647 -LRB- denotes (
T3514 647-653 NN denotes figure
T3515 654-656 NN denotes 1a
T3516 656-657 -RRB- denotes )
T3517 659-661 NN denotes HK
T3518 662-664 FW denotes E.
T3519 665-669 FW denotes coli
T3520 670-679 NN denotes treatment
T3521 680-683 VB denotes did
T3522 684-687 RB denotes not
T3523 688-694 VB denotes affect
T3524 695-699 NN denotes AP-1
T3525 700-710 NN denotes activation
T3526 711-713 IN denotes in
T3527 714-720 NN denotes Jurkat
T3528 721-728 NN denotes T-cells
T3529 729-730 -LRB- denotes (
T3530 730-736 NN denotes figure
T3531 737-739 NN denotes 1b
T3532 739-740 -RRB- denotes )
T3533 742-744 TO denotes To
T3534 745-754 VB denotes determine
T3535 755-758 DT denotes the
T3536 759-770 NN denotes involvement
T3537 771-773 IN denotes of
T3538 774-784 VB denotes associated
T3539 785-793 NN denotes pathways
T3540 793-794 -COMMA- denotes ,
T3541 795-797 PRP denotes we
T3542 798-805 VB denotes exposed
T3543 806-811 NN denotes cells
T3544 812-814 TO denotes to
T3545 815-819 NN denotes Ca2+
T3546 820-829 NN denotes ionophore
T3547 830-834 IN denotes with
T3548 835-837 CC denotes or
T3549 838-845 IN denotes without
T3550 846-849 NN denotes PMA
T3551 850-853 CC denotes and
T3552 854-862 VB denotes observed
T3553 863-864 DT denotes a
T3554 865-871 JJ denotes modest
T3555 872-883 NN denotes involvement
T3556 884-886 IN denotes of
T3557 887-891 NN denotes Ca2+
T3558 892-894 IN denotes in
T3559 895-908 JJ denotes PMA-dependent
T3560 909-913 NN denotes AP-1
T3561 914-924 NN denotes activation
T3562 925-926 -LRB- denotes (
T3563 926-932 NN denotes figure
T3564 933-935 NN denotes 1c
T3565 935-936 -RRB- denotes )
T3566 937-942 IN denotes while
T3567 943-947 NN denotes Ca2+
T3568 948-953 RB denotes alone
T3569 954-957 VB denotes did
T3570 958-961 RB denotes not
T3571 962-967 VB denotes alter
T3572 968-972 NN denotes AP-1
T3573 973-981 NN denotes activity
T3574 982-983 -LRB- denotes (
T3575 983-987 NN denotes data
T3576 988-991 RB denotes not
T3577 992-997 VB denotes shown
T3578 997-998 -RRB- denotes )
T3579 1000-1011 RB denotes Furthermore
T3580 1011-1012 -COMMA- denotes ,
T3581 1013-1017 NN denotes AP-1
T3582 1018-1026 NN denotes activity
T3583 1027-1036 VB denotes decreased
T3584 1037-1039 IN denotes in
T3585 1040-1041 DT denotes a
T3586 1042-1055 JJ denotes TCR-deficient
T3587 1056-1062 NN denotes Jurkat
T3588 1063-1067 NN denotes cell
T3589 1068-1072 NN denotes line
T3590 1073-1077 WRB denotes when
T3591 1078-1085 VB denotes exposed
T3592 1086-1088 TO denotes to
T3593 1089-1092 NN denotes PMA
T3594 1093-1101 VB denotes compared
T3595 1102-1104 TO denotes to
T3596 1105-1108 DT denotes the
T3597 1109-1115 NN denotes parent
T3598 1116-1120 NN denotes cell
T3599 1121-1125 NN denotes line
T3600 1126-1136 VB denotes indicating
T3601 1137-1141 IN denotes that
T3602 1142-1152 NN denotes regulation
T3603 1153-1155 IN denotes of
T3604 1156-1160 NN denotes AP-1
T3605 1161-1164 VB denotes was
T3606 1165-1169 RB denotes only
T3607 1170-1179 RB denotes partially
T3608 1180-1186 NN denotes T-cell
T3609 1187-1195 NN denotes receptor
T3610 1196-1205 JJ denotes dependent
T3611 1206-1207 -LRB- denotes (
T3612 1207-1213 NN denotes figure
T3613 1214-1216 NN denotes 1d
T3614 1216-1217 -RRB- denotes )
T3615 1856-1861 NN denotes NF-κB
T3616 1862-1868 NN denotes levels
T3617 1869-1875 VB denotes showed
T3618 1876-1877 DT denotes a
T3619 1878-1887 JJ denotes transient
T3620 1888-1896 NN denotes increase
T3621 1897-1899 IN denotes at
T3622 1900-1901 CD denotes 1
T3623 1902-1905 NN denotes min
T3624 1906-1911 IN denotes after
T3625 1912-1920 NN denotes exposure
T3626 1921-1923 TO denotes to
T3627 1924-1927 NN denotes PMA
T3628 1928-1929 -LRB- denotes (
T3629 1929-1935 NN denotes figure
T3630 1936-1938 NN denotes 2a
T3631 1938-1939 -RRB- denotes )
T3632 1941-1948 RB denotes However
T3633 1948-1949 -COMMA- denotes ,
T3634 1950-1951 CD denotes 1
T3635 1952-1953 NN denotes h
T3636 1954-1959 IN denotes after
T3637 1960-1968 NN denotes exposure
T3638 1969-1972 DT denotes the
T3639 1973-1978 NN denotes NF-κB
T3640 1979-1985 NN denotes levels
T3641 1986-1991 VB denotes began
T3642 1992-1994 TO denotes to
T3643 1995-1999 VB denotes drop
T3644 2000-2008 VB denotes reaching
T3645 2009-2012 DT denotes the
T3646 2013-2019 JJ denotes lowest
T3647 2020-2026 NN denotes levels
T3648 2027-2029 IN denotes by
T3649 2030-2031 CD denotes 6
T3650 2032-2033 NN denotes h
T3651 2033-2034 -COMMA- denotes ,
T3652 2035-2040 IN denotes after
T3653 2041-2046 WDT denotes which
T3654 2047-2051 PRP denotes they
T3655 2052-2061 VB denotes increased
T3656 2062-2067 RB denotes again
T3657 2068-2070 IN denotes by
T3658 2071-2073 CD denotes 24
T3659 2074-2075 NN denotes h
T3660 2077-2085 NN denotes Exposure
T3661 2086-2088 IN denotes of
T3662 2089-2095 NN denotes Jurkat
T3663 2096-2103 NN denotes T-cells
T3664 2104-2106 TO denotes to
T3665 2107-2109 NN denotes HK
T3666 2110-2112 NNP denotes E.
T3667 2113-2117 FW denotes coli
T3668 2118-2126 VB denotes resulted
T3669 2127-2129 IN denotes in
T3670 2130-2131 DT denotes a
T3671 2132-2146 JJ denotes dose-dependent
T3672 2147-2152 NN denotes NF-κB
T3673 2153-2163 NN denotes activation
T3674 2163-2164 -COMMA- denotes ,
T3675 2165-2169 IN denotes with
T3676 2170-2173 DT denotes the
T3677 2174-2181 JJ denotes highest
T3678 2182-2190 NN denotes activity
T3679 2191-2199 VB denotes observed
T3680 2200-2202 IN denotes at
T3681 2203-2204 DT denotes a
T3682 2205-2213 JJ denotes relative
T3683 2214-2227 NN denotes concentration
T3684 2228-2230 IN denotes of
T3685 2231-2232 CD denotes 5
T3686 2233-2234 -COLON- denotes ×
T3687 2235-2238 CD denotes 107
T3688 2239-2245 NNP denotes CFU/ml
T3689 2246-2247 -LRB- denotes (
T3690 2247-2253 NN denotes figure
T3691 2254-2256 NN denotes 2b
T3692 2256-2257 -RRB- denotes )
T3693 2259-2262 DT denotes The
T3694 2263-2277 JJ denotes time-dependent
T3695 2278-2288 NN denotes activation
T3696 2289-2291 IN denotes of
T3697 2292-2297 NN denotes NF-κB
T3698 2298-2300 IN denotes by
T3699 2301-2303 NN denotes HK
T3700 2304-2306 FW denotes E.
T3701 2307-2311 FW denotes coli
T3702 2312-2315 VB denotes was
T3703 2316-2324 VB denotes assessed
T3704 2325-2332 RB denotes further
T3705 2333-2338 VB denotes using
T3706 2339-2342 DT denotes the
T3707 2343-2350 JJ denotes optimal
T3708 2351-2364 NN denotes concentration
T3709 2365-2373 VB denotes obtained
T3710 2374-2378 IN denotes from
T3711 2379-2385 NN denotes figure
T3712 2386-2388 NN denotes 2b
T3713 2389-2392 CC denotes and
T3714 2393-2399 VB denotes showed
T3715 2400-2404 IN denotes that
T3716 2405-2408 DT denotes the
T3717 2409-2414 NN denotes NF-κB
T3718 2415-2423 NN denotes activity
T3719 2424-2433 VB denotes increased
T3720 2434-2439 IN denotes after
T3721 2440-2441 CD denotes 3
T3722 2442-2443 NN denotes h
T3723 2444-2446 IN denotes of
T3724 2447-2455 NN denotes exposure
T3725 2456-2457 -LRB- denotes (
T3726 2457-2463 NN denotes figure
T3727 2464-2466 NN denotes 2c
T3728 2466-2467 -RRB- denotes )
T3729 2469-2480 RB denotes Furthermore
T3730 2480-2481 -COMMA- denotes ,
T3731 2482-2491 VB denotes increased
T3732 2492-2505 JJ denotes intracellular
T3733 2506-2510 NN denotes Ca2+
T3734 2511-2519 VB denotes reversed
T3735 2520-2523 DT denotes the
T3736 2524-2527 NN denotes PMA
T3737 2528-2537 JJ denotes dependent
T3738 2538-2543 NN denotes NF-κB
T3739 2544-2554 NN denotes inhibition
T3740 2555-2556 -LRB- denotes (
T3741 2556-2562 NN denotes figure
T3742 2563-2565 NN denotes 2d
T3743 2565-2566 -RRB- denotes )
T3744 2567-2570 CC denotes and
T3745 2571-2578 VB denotes reduced
T3746 2579-2582 DT denotes the
T3747 2583-2585 NN denotes HK
T3748 2586-2588 FW denotes E.
T3749 2589-2593 FW denotes coli
T3750 2594-2604 JJ denotes -dependent
T3751 2605-2610 NN denotes NF-κB
T3752 2611-2621 NN denotes activation
T3753 2622-2623 -LRB- denotes (
T3754 2623-2629 NN denotes figure
T3755 2630-2632 NN denotes 2e
T3756 2632-2633 -RRB- denotes )
T4162 3298-3307 NN denotes Induction
T4163 3308-3310 IN denotes of
T4164 3311-3323 JJ denotes inflammatory
T4165 3324-3333 NN denotes responses
T4166 3334-3337 DT denotes The
T4167 3338-3345 NN denotes ability
T4168 3346-3348 IN denotes of
T4169 3349-3352 NN denotes PMA
T4170 3353-3356 CC denotes and
T4171 3357-3359 NN denotes HK
T4172 3360-3362 FW denotes E.
T4173 3363-3367 FW denotes coli
T4174 3368-3370 TO denotes to
T4175 3371-3377 VB denotes induce
T4176 3378-3380 DT denotes an
T4177 3381-3393 JJ denotes inflammatory
T4178 3394-3402 NN denotes response
T4179 3403-3405 IN denotes in
T4180 3406-3412 NN denotes Jurkat
T4181 3413-3420 NN denotes T-cells
T4182 3421-3424 VB denotes was
T4183 3425-3434 VB denotes evaluated
T4184 3435-3440 VB denotes using
T4185 3441-3442 DT denotes a
T4186 3443-3452 JJ denotes multiplex
T4187 3453-3461 NN denotes cytokine
T4188 3462-3467 NN denotes assay
T4189 3468-3477 VB denotes following
T4190 3478-3480 CD denotes 24
T4191 3481-3482 NN denotes h
T4192 3483-3494 NN denotes stimulation
T4193 3496-3499 DT denotes The
T4194 3500-3508 NN denotes cytokine
T4195 3509-3516 NN denotes profile
T4196 3517-3525 VB denotes revealed
T4197 3526-3528 DT denotes an
T4198 3529-3537 VB denotes enhanced
T4199 3538-3547 NN denotes induction
T4200 3548-3550 IN denotes of
T4201 3551-3554 DT denotes the
T4202 3555-3571 JJ denotes pro-inflammatory
T4203 3572-3581 NN denotes cytokines
T4204 3582-3586 NN denotes IL-2
T4205 3586-3587 -COMMA- denotes ,
T4206 3588-3592 NN denotes IL-6
T4207 3592-3593 -COMMA- denotes ,
T4208 3594-3597 NN denotes TNF
T4209 3598-3601 CC denotes and
T4210 3602-3605 DT denotes the
T4211 3606-3615 NN denotes chemokine
T4212 3616-3621 NN denotes CXCL8
T4213 3623-3626 DT denotes The
T4214 3627-3633 NN denotes levels
T4215 3634-3636 IN denotes of
T4216 3637-3640 DT denotes the
T4217 3641-3658 JJ denotes anti-inflammatory
T4218 3659-3667 NN denotes cytokine
T4219 3668-3673 NN denotes IL-10
T4220 3674-3678 VB denotes were
T4221 3679-3689 JJ denotes unaffected
T4222 3690-3692 IN denotes by
T4223 3693-3696 NN denotes PMA
T4224 3697-3700 CC denotes but
T4225 3701-3705 VB denotes were
T4226 3706-3719 RB denotes significantly
T4227 3720-3729 VB denotes decreased
T4228 3730-3732 IN denotes by
T4229 3733-3735 NN denotes HK
T4230 3736-3738 FW denotes E.
T4231 3739-3743 FW denotes coli
T4232 3744-3745 -LRB- denotes (
T4233 3745-3750 JJ denotes Table
T4234 3751-3752 CD denotes 1
T4235 3752-3753 -RRB- denotes )
T4236 3755-3760 DT denotes These
T4237 3761-3768 NN denotes results
T4238 3769-3778 VB denotes confirmed
T4239 3779-3783 IN denotes that
T4240 3784-3787 NN denotes PMA
T4241 3788-3791 CC denotes and
T4242 3792-3794 NN denotes HK
T4243 3795-3797 FW denotes E.
T4244 3798-3802 FW denotes coli
T4245 3803-3810 VB denotes induced
T4246 3811-3813 DT denotes an
T4247 3814-3826 JJ denotes inflammatory
T4248 3827-3835 NN denotes response
T4249 3836-3838 IN denotes in
T4250 3839-3842 DT denotes the
T4251 3843-3849 NN denotes Jurkat
T4252 3850-3857 NN denotes T-cells
T4253 3859-3861 PRP denotes It
T4254 3862-3864 VB denotes is
T4255 3865-3876 JJ denotes interesting
T4256 3877-3879 TO denotes to
T4257 3880-3884 VB denotes note
T4258 3885-3889 DT denotes that
T4259 3890-3893 NN denotes PMA
T4260 3894-3897 VB denotes was
T4261 3898-3906 RB denotes 120-fold
T4262 3907-3911 RB denotes more
T4263 3912-3921 JJ denotes effective
T4264 3922-3924 IN denotes at
T4265 3925-3933 VB denotes inducing
T4266 3934-3939 NN denotes CXCL8
T4267 3940-3944 IN denotes than
T4268 3945-3947 NN denotes HK
T4269 3948-3950 FW denotes E.
T4270 3951-3955 FW denotes coli
T4271 3957-3970 JJ denotes PMA-dependent
T4272 3971-3980 NN denotes induction
T4273 3981-3983 IN denotes of
T4274 3984-3988 NN denotes AP-1
T4275 3989-3992 CC denotes and
T4276 3993-4008 NN denotes down-regulation
T4277 4009-4011 IN denotes of
T4278 4012-4017 NN denotes NF-κB
T4279 4018-4026 VB denotes suggests
T4280 4027-4029 DT denotes an
T4281 4030-4041 NN denotes involvement
T4282 4042-4044 IN denotes of
T4283 4045-4049 NN denotes AP-1
T4284 4050-4052 IN denotes in
T4285 4053-4058 NN denotes CXCL8
T4286 4059-4069 NN denotes regulation
T4287 4071-4084 NN denotes Determination
T4288 4085-4087 IN denotes of
T4289 4088-4091 DT denotes the
T4290 4092-4096 NN denotes time
T4291 4097-4103 NN denotes course
T4292 4104-4106 IN denotes of
T4293 4107-4115 NN denotes cytokine
T4294 4116-4125 NN denotes induction
T4295 4126-4128 IN denotes in
T4296 4129-4137 NN denotes response
T4297 4138-4140 TO denotes to
T4298 4141-4144 NN denotes PMA
T4299 4145-4151 VB denotes showed
T4300 4152-4156 IN denotes that
T4301 4157-4162 NN denotes CXCL8
T4302 4163-4166 VB denotes was
T4303 4167-4174 RB denotes already
T4304 4175-4183 VB denotes released
T4305 4184-4191 IN denotes between
T4306 4192-4195 CD denotes 2-6
T4307 4196-4197 NN denotes h
T4308 4197-4198 -COMMA- denotes ,
T4309 4199-4204 IN denotes while
T4310 4205-4208 NN denotes TNF
T4311 4209-4212 CC denotes and
T4312 4213-4217 NN denotes IL-6
T4313 4218-4222 VB denotes were
T4314 4223-4231 VB denotes released
T4315 4232-4239 IN denotes between
T4316 4240-4244 CD denotes 6-24
T4317 4245-4246 NN denotes h
T4318 4247-4248 -LRB- denotes (
T4319 4248-4254 NN denotes figure
T4320 4255-4256 CD denotes 3
T4321 4256-4257 -RRB- denotes )
T4322 4259-4264 DT denotes These
T4323 4265-4272 NN denotes results
T4324 4273-4282 VB denotes indicated
T4325 4283-4287 IN denotes that
T4326 4288-4291 DT denotes the
T4327 4292-4301 NN denotes cytokines
T4328 4302-4306 VB denotes were
T4329 4307-4321 RB denotes differentially
T4330 4322-4331 VB denotes regulated
T4331 4332-4335 CC denotes and
T4332 4336-4340 IN denotes that
T4333 4341-4344 DT denotes the
T4334 4345-4352 NN denotes release
T4335 4353-4356 VB denotes was
T4336 4357-4360 RB denotes not
T4337 4361-4371 VB denotes associated
T4338 4372-4376 IN denotes with
T4339 4377-4380 DT denotes the
T4340 4381-4386 JJ denotes early
T4341 4387-4396 JJ denotes transient
T4342 4397-4406 NN denotes induction
T4343 4407-4409 IN denotes of
T4344 4410-4415 NN denotes NF-κB
T4345 4417-4420 DT denotes The
T4346 4421-4429 JJ denotes temporal
T4347 4430-4439 NN denotes induction
T4348 4440-4442 IN denotes of
T4349 4443-4447 NN denotes AP-1
T4350 4448-4458 VB denotes correlated
T4351 4459-4461 TO denotes to
T4352 4462-4465 DT denotes the
T4353 4466-4471 NN denotes CXCL8
T4354 4472-4478 NN denotes levels
T4355 4479-4482 CC denotes and
T4356 4483-4491 VB denotes preceded
T4357 4492-4495 DT denotes the
T4358 4496-4499 NN denotes TNF
T4359 4500-4503 CC denotes and
T4360 4504-4508 NN denotes IL-6
T4361 4509-4516 NN denotes release
T4362 4518-4522 DT denotes This
T4363 4523-4531 VB denotes suggests
T4364 4532-4534 DT denotes an
T4365 4535-4546 NN denotes association
T4366 4547-4554 IN denotes between
T4367 4555-4560 NN denotes CXCL8
T4368 4561-4568 NN denotes release
T4369 4569-4572 CC denotes and
T4370 4573-4577 NN denotes AP-1
T4371 4578-4588 NN denotes signalling
T5145 5410-5421 JJ denotes Cooperative
T5146 5422-5431 NN denotes induction
T5147 5432-5434 IN denotes of
T5148 5435-5444 NN denotes cytokines
T5149 5445-5447 IN denotes by
T5150 5448-5452 NN denotes AP-1
T5151 5453-5456 CC denotes and
T5152 5457-5462 NN denotes NF-κB
T5153 5463-5465 TO denotes To
T5154 5466-5473 RB denotes further
T5155 5474-5486 VB denotes characterize
T5156 5487-5490 DT denotes the
T5157 5491-5502 NN denotes involvement
T5158 5503-5505 IN denotes of
T5159 5506-5511 NN denotes NF-κB
T5160 5512-5514 IN denotes in
T5161 5515-5523 NN denotes cytokine
T5162 5524-5534 NN denotes regulation
T5163 5534-5535 -COMMA- denotes ,
T5164 5536-5538 PRP denotes we
T5165 5539-5546 VB denotes treated
T5166 5547-5552 NN denotes cells
T5167 5553-5557 IN denotes with
T5168 5558-5560 DT denotes an
T5169 5561-5566 NN denotes NF-κB
T5170 5567-5577 NN denotes activation
T5171 5578-5587 NN denotes inhibitor
T5172 5588-5589 -LRB- denotes (
T5173 5589-5592 NN denotes NAI
T5174 5592-5593 -RRB- denotes )
T5175 5595-5598 DT denotes The
T5176 5599-5606 NN denotes results
T5177 5607-5613 VB denotes showed
T5178 5614-5618 IN denotes that
T5179 5619-5622 NN denotes NAI
T5180 5623-5634 RB denotes selectively
T5181 5635-5649 VB denotes down-regulated
T5182 5650-5655 NN denotes NF-κB
T5183 5656-5666 NN denotes activation
T5184 5667-5668 -LRB- denotes (
T5185 5668-5675 NN denotes figures
T5186 5676-5678 NN denotes 4a
T5187 5679-5682 CC denotes and
T5188 5683-5685 NN denotes 4b
T5189 5685-5686 -RRB- denotes )
T5190 5687-5690 CC denotes and
T5191 5691-5694 VB denotes did
T5192 5695-5698 RB denotes not
T5193 5699-5704 VB denotes alter
T5194 5705-5709 NN denotes AP-1
T5195 5710-5718 NN denotes activity
T5196 5719-5720 -LRB- denotes (
T5197 5720-5727 NN denotes figures
T5198 5728-5730 NN denotes 4c
T5199 5731-5734 CC denotes and
T5200 5735-5737 NN denotes 4d
T5201 5737-5738 -RRB- denotes )
T5202 5740-5748 NN denotes Exposure
T5203 5749-5751 IN denotes of
T5204 5752-5758 NN denotes Jurkat
T5205 5759-5766 NN denotes T-cells
T5206 5767-5769 TO denotes to
T5207 5770-5773 NN denotes NAI
T5208 5774-5782 VB denotes resulted
T5209 5783-5785 IN denotes in
T5210 5786-5787 DT denotes a
T5211 5788-5794 JJ denotes modest
T5212 5795-5804 NN denotes reduction
T5213 5805-5807 IN denotes of
T5214 5808-5813 NN denotes CXCL8
T5215 5814-5823 VB denotes following
T5216 5824-5827 NN denotes PMA
T5217 5828-5836 NN denotes exposure
T5218 5836-5837 -COMMA- denotes ,
T5219 5838-5843 IN denotes while
T5220 5844-5846 PRP denotes it
T5221 5847-5850 VB denotes did
T5222 5851-5854 RB denotes not
T5223 5855-5860 VB denotes alter
T5224 5861-5864 DT denotes the
T5225 5865-5870 NN denotes CXCL8
T5226 5871-5878 NN denotes release
T5227 5879-5888 VB denotes following
T5228 5889-5891 NN denotes HK
T5229 5892-5894 FW denotes E.
T5230 5895-5899 FW denotes coli
T5231 5900-5908 NN denotes exposure
T5232 5909-5910 -LRB- denotes (
T5233 5910-5916 NN denotes figure
T5234 5917-5919 NN denotes 5a
T5235 5919-5920 -RRB- denotes )
T5236 5922-5925 NN denotes NAI
T5237 5926-5929 VB denotes did
T5238 5930-5933 RB denotes not
T5239 5934-5940 VB denotes affect
T5240 5941-5944 NN denotes TNF
T5241 5945-5955 NN denotes expression
T5242 5956-5957 -LRB- denotes (
T5243 5957-5963 NN denotes figure
T5244 5964-5966 NN denotes 5b
T5245 5966-5967 -RRB- denotes )
T5246 5968-5978 VB denotes indicating
T5247 5979-5983 IN denotes that
T5248 5984-5989 NN denotes NF-κB
T5249 5990-5992 VB denotes is
T5250 5993-5996 RB denotes not
T5251 5997-6000 DT denotes the
T5252 6001-6005 JJ denotes main
T5253 6006-6015 NN denotes regulator
T5254 6016-6018 IN denotes of
T5255 6019-6024 NN denotes CXCL8
T5256 6025-6027 CC denotes or
T5257 6028-6031 NN denotes TNF
T5258 6032-6041 VB denotes following
T5259 6042-6048 CC denotes either
T5260 6049-6052 NN denotes PMA
T5261 6053-6055 CC denotes or
T5262 6056-6058 NN denotes HK
T5263 6059-6061 FW denotes E.
T5264 6062-6066 FW denotes coli
T5265 6067-6075 NN denotes exposure
T5266 6076-6078 IN denotes in
T5267 6079-6085 NN denotes Jurkat
T5268 6086-6093 NN denotes T-cells
T5269 6095-6097 IN denotes In
T5270 6098-6106 NN denotes contrast
T5271 6106-6107 -COMMA- denotes ,
T5272 6108-6111 NN denotes NAI
T5273 6112-6120 VB denotes resulted
T5274 6121-6123 IN denotes in
T5275 6124-6125 DT denotes a
T5276 6126-6134 JJ denotes complete
T5277 6135-6145 NN denotes inhibition
T5278 6146-6148 IN denotes of
T5279 6149-6153 NN denotes IL-6
T5280 6154-6163 VB denotes following
T5281 6164-6167 NN denotes PMA
T5282 6168-6176 NN denotes exposure
T5283 6177-6180 CC denotes and
T5284 6181-6182 DT denotes a
T5285 6183-6185 CD denotes 45
T5286 6185-6186 NN denotes %
T5287 6187-6197 NN denotes inhibition
T5288 6198-6207 VB denotes following
T5289 6208-6210 NN denotes HK
T5290 6211-6213 FW denotes E.
T5291 6214-6218 FW denotes coli
T5292 6219-6227 NN denotes exposure
T5293 6228-6229 -LRB- denotes (
T5294 6229-6235 NN denotes figure
T5295 6236-6238 NN denotes 5c
T5296 6238-6239 -RRB- denotes )
T5297 6239-6240 -COMMA- denotes ,
T5298 6241-6251 VB denotes suggesting
T5299 6252-6254 DT denotes an
T5300 6255-6266 NN denotes involvement
T5301 6267-6269 IN denotes of
T5302 6270-6275 NN denotes NF-κB
T5303 6276-6278 IN denotes in
T5304 6279-6283 NN denotes IL-6
T5305 6284-6294 NN denotes regulation
T5306 7593-7597 NN denotes Ca2+
T5307 7598-7601 VB denotes was
T5308 7602-7610 VB denotes observed
T5309 7611-7613 TO denotes to
T5310 7614-7622 VB denotes increase
T5311 7623-7627 NN denotes AP-1
T5312 7628-7636 NN denotes activity
T5313 7637-7638 -LRB- denotes (
T5314 7638-7644 NN denotes figure
T5315 7645-7647 NN denotes 1c
T5316 7647-7648 -RRB- denotes )
T5317 7649-7652 CC denotes and
T5318 7653-7659 VB denotes reduce
T5319 7660-7665 NN denotes NF-κB
T5320 7666-7674 NN denotes activity
T5321 7675-7676 -LRB- denotes (
T5322 7676-7682 NN denotes figure
T5323 7683-7685 NN denotes 2e
T5324 7685-7686 -RRB- denotes )
T5325 7686-7687 -COLON- denotes ;
T5326 7688-7697 RB denotes therefore
T5327 7697-7698 -COMMA- denotes ,
T5328 7699-7701 PRP denotes we
T5329 7702-7709 VB denotes exposed
T5330 7710-7717 NN denotes T-cells
T5331 7718-7720 TO denotes to
T5332 7721-7722 DT denotes a
T5333 7723-7726 NN denotes PKC
T5334 7727-7736 NN denotes inhibitor
T5335 7737-7745 RB denotes together
T5336 7746-7750 IN denotes with
T5337 7751-7754 NN denotes PMA
T5338 7755-7757 TO denotes to
T5339 7758-7767 VB denotes determine
T5340 7768-7771 PRP-DOLLAR- denotes its
T5341 7772-7778 NN denotes effect
T5342 7779-7781 IN denotes on
T5343 7782-7790 NN denotes cytokine
T5344 7791-7801 NN denotes expression
T5345 7803-7813 NN denotes Inhibition
T5346 7814-7816 IN denotes of
T5347 7817-7820 NN denotes PKC
T5348 7821-7828 VB denotes reduced
T5349 7829-7834 NN denotes CXCL8
T5350 7835-7842 NN denotes release
T5351 7843-7847 IN denotes from
T5352 7848-7849 CD denotes 7
T5353 7850-7855 NN denotes ng/ml
T5354 7856-7858 TO denotes to
T5355 7859-7860 CD denotes 3
T5356 7861-7866 NN denotes ng/ml
T5357 7867-7872 IN denotes while
T5358 7873-7875 PRP denotes it
T5359 7876-7879 VB denotes had
T5360 7880-7881 DT denotes a
T5361 7882-7888 JJ denotes modest
T5362 7889-7895 NN denotes effect
T5363 7896-7898 IN denotes on
T5364 7899-7903 NN denotes IL-6
T5365 7904-7907 CC denotes and
T5366 7908-7911 NN denotes TNF
T5367 7912-7913 -LRB- denotes (
T5368 7913-7919 NN denotes figure
T5369 7920-7924 NN denotes 6a-c
T5370 7924-7925 -RRB- denotes )
T5371 7927-7931 DT denotes This
T5372 7932-7940 VB denotes prompted
T5373 7941-7943 PRP denotes us
T5374 7944-7946 TO denotes to
T5375 7947-7951 VB denotes test
T5376 7952-7955 DT denotes the
T5377 7956-7962 NN denotes effect
T5378 7963-7965 IN denotes of
T5379 7966-7969 NN denotes JNK
T5380 7970-7980 NN denotes inhibition
T5381 7981-7983 IN denotes on
T5382 7984-7995 JJ denotes PMA-induced
T5383 7996-8004 NN denotes cytokine
T5384 8005-8015 NN denotes expression
T5385 8017-8020 NN denotes JNK
T5386 8021-8023 VB denotes is
T5387 8024-8032 VB denotes involved
T5388 8033-8035 IN denotes in
T5389 8036-8039 DT denotes the
T5390 8040-8050 NN denotes regulation
T5391 8051-8053 IN denotes of
T5392 8054-8055 DT denotes a
T5393 8056-8065 NN denotes multitude
T5394 8066-8068 IN denotes of
T5395 8069-8078 JJ denotes different
T5396 8079-8092 NN denotes transcription
T5397 8093-8100 NN denotes factors
T5398 8100-8101 -COMMA- denotes ,
T5399 8102-8111 VB denotes including
T5400 8112-8115 DT denotes the
T5401 8116-8131 NN denotes phosphorylation
T5402 8132-8135 CC denotes and
T5403 8136-8146 NN denotes activation
T5404 8147-8149 IN denotes of
T5405 8150-8155 NN denotes c-Jun
T5406 8155-8156 -COMMA- denotes ,
T5407 8157-8162 NN denotes c-Fos
T5408 8163-8166 CC denotes and
T5409 8167-8170 NN denotes p53
T5410 8170-8171 -COMMA- denotes ,
T5411 8172-8179 VB denotes leading
T5412 8180-8182 TO denotes to
T5413 8183-8191 JJ denotes cellular
T5414 8192-8201 NN denotes apoptosis
T5415 8202-8203 -LRB- denotes [
T5416 8203-8205 CD denotes 26
T5417 8205-8206 -RRB- denotes ]
T5418 8208-8218 NN denotes Inhibition
T5419 8219-8221 IN denotes of
T5420 8222-8225 DT denotes the
T5421 8226-8229 NN denotes JNK
T5422 8230-8238 NN denotes pathways
T5423 8239-8247 VB denotes resulted
T5424 8248-8250 IN denotes in
T5425 8251-8252 DT denotes a
T5426 8253-8268 NN denotes down-regulation
T5427 8269-8271 IN denotes of
T5428 8272-8276 CC denotes both
T5429 8277-8282 NN denotes CXCL8
T5430 8283-8286 CC denotes and
T5431 8287-8291 NN denotes IL-6
T5432 8291-8292 -COMMA- denotes ,
T5433 8293-8298 IN denotes while
T5434 8299-8301 DT denotes no
T5435 8302-8307 JJ denotes clear
T5436 8308-8314 NN denotes effect
T5437 8315-8318 VB denotes was
T5438 8319-8327 VB denotes observed
T5439 8328-8330 IN denotes on
T5440 8331-8334 NN denotes TNF
T5441 8335-8345 NN denotes expression
T5442 8346-8347 -LRB- denotes (
T5443 8347-8353 NN denotes figure
T5444 8354-8358 NN denotes 6a-c
T5445 8358-8359 -RRB- denotes )
T5446 8361-8369 NN denotes Analysis
T5447 8370-8372 IN denotes of
T5448 8373-8377 NN denotes mRNA
T5449 8378-8384 NN denotes levels
T5450 8385-8390 VB denotes using
T5451 8391-8398 NN denotes RT-qPCR
T5452 8399-8400 -LRB- denotes (
T5453 8400-8405 NN denotes table
T5454 8406-8407 CD denotes 2
T5455 8407-8408 -RRB- denotes )
T5456 8409-8415 VB denotes showed
T5457 8416-8420 IN denotes that
T5458 8421-8424 NN denotes PMA
T5459 8425-8432 VB denotes induced
T5460 8433-8437 CC denotes both
T5461 8438-8442 NN denotes il-6
T5462 8443-8446 CC denotes and
T5463 8447-8452 NN denotes cxcl8
T5464 8453-8457 NN denotes mRNA
T5465 8458-8459 -LRB- denotes (
T5466 8459-8467 JJ denotes 5.1-fold
T5467 8468-8471 CC denotes and
T5468 8472-8477 CD denotes 111.8
T5469 8478-8482 RB denotes fold
T5470 8483-8495 RB denotes respectively
T5471 8495-8496 -RRB- denotes )
T5472 8498-8506 NN denotes Addition
T5473 8507-8509 IN denotes of
T5474 8510-8513 DT denotes the
T5475 8514-8519 NN denotes NF-κB
T5476 8520-8529 NN denotes inhibitor
T5477 8530-8533 NN denotes NAI
T5478 8534-8537 CC denotes and
T5479 8538-8541 DT denotes the
T5480 8542-8545 NN denotes JNK
T5481 8546-8555 NN denotes inhibitor
T5482 8556-8563 VB denotes reduced
T5483 8564-8567 DT denotes the
T5484 8568-8572 NN denotes il-6
T5485 8573-8583 NN denotes expression
T5486 8584-8589 IN denotes below
T5487 8590-8595 JJ denotes basal
T5488 8596-8602 NN denotes levels
T5489 8604-8606 IN denotes In
T5490 8607-8615 NN denotes contrast
T5491 8615-8616 -COMMA- denotes ,
T5492 8617-8622 IN denotes while
T5493 8623-8626 DT denotes the
T5494 8627-8632 NN denotes cxcl8
T5495 8633-8639 NN denotes levels
T5496 8640-8644 VB denotes were
T5497 8645-8655 VB denotes suppressed
T5498 8656-8658 IN denotes by
T5499 8659-8662 DT denotes the
T5500 8663-8667 JJ denotes same
T5501 8668-8678 NN denotes treatments
T5502 8679-8682 DT denotes the
T5503 8683-8689 NN denotes levels
T5504 8690-8698 VB denotes remained
T5505 8699-8707 JJ denotes elevated
T5506 8708-8713 IN denotes above
T5507 8714-8719 JJ denotes basal
T5508 8720-8725 NN denotes level
T6147 9634-9639 NN denotes NF-κB
T6148 9640-9650 NN denotes inhibition
T6149 9651-9654 JJ denotes due
T6150 9655-9657 TO denotes to
T6151 9658-9671 JJ denotes PKC-dependent
T6152 9672-9677 NN denotes Bcl10
T6153 9678-9689 NN denotes degradation
T6154 9690-9697 NN denotes Western
T6155 9698-9702 NN denotes blot
T6156 9703-9711 NN denotes analysis
T6157 9712-9720 VB denotes revealed
T6158 9721-9723 DT denotes an
T6159 9724-9737 NN denotes up-regulation
T6160 9738-9740 IN denotes of
T6161 9741-9759 NN denotes phosphorylated-PKC
T6162 9760-9765 IN denotes after
T6163 9766-9768 CD denotes 24
T6164 9769-9770 NN denotes h
T6165 9771-9780 NN denotes treatment
T6166 9781-9783 IN denotes of
T6167 9784-9790 NN denotes Jurkat
T6168 9791-9798 NN denotes T-cells
T6169 9799-9803 IN denotes with
T6170 9804-9807 NN denotes PMA
T6171 9808-9810 CC denotes or
T6172 9811-9813 NN denotes HK
T6173 9814-9816 FW denotes E.
T6174 9817-9821 FW denotes coli
T6175 9822-9823 -LRB- denotes (
T6176 9823-9829 NN denotes figure
T6177 9830-9832 NN denotes 7a
T6178 9832-9833 -RRB- denotes )
T6179 9833-9834 -COMMA- denotes ,
T6180 9835-9840 IN denotes while
T6181 9841-9845 NN denotes IκBβ
T6182 9846-9852 NN denotes levels
T6183 9853-9861 VB denotes remained
T6184 9862-9872 JJ denotes unaffected
T6185 9873-9874 -LRB- denotes (
T6186 9874-9880 NN denotes figure
T6187 9881-9883 NN denotes 7b
T6188 9883-9884 -RRB- denotes )
T6189 9886-9891 NN denotes Bcl10
T6190 9892-9894 VB denotes is
T6191 9895-9896 DT denotes a
T6192 9897-9907 NN denotes signalling
T6193 9908-9915 NN denotes protein
T6194 9916-9920 WDT denotes that
T6195 9921-9925 VB denotes acts
T6196 9926-9934 RB denotes upstream
T6197 9935-9937 IN denotes of
T6198 9938-9943 NN denotes NF-κB
T6199 9944-9946 IN denotes in
T6200 9947-9954 NN denotes concert
T6201 9955-9959 IN denotes with
T6202 9960-9966 NN denotes CARMA1
T6203 9967-9970 CC denotes and
T6204 9971-9976 NN denotes MALT1
T6205 9977-9980 CC denotes and
T6206 9981-9984 VB denotes has
T6207 9985-9989 VB denotes been
T6208 9990-9999 VB denotes suggested
T6209 10000-10002 TO denotes to
T6210 10003-10011 RB denotes directly
T6211 10012-10020 VB denotes regulate
T6212 10021-10026 NN denotes NF-κB
T6213 10027-10035 NN denotes activity
T6214 10036-10038 IN denotes in
T6215 10039-10046 NN denotes T-cells
T6216 10047-10048 -LRB- denotes [
T6217 10048-10050 CD denotes 27
T6218 10050-10051 -RRB- denotes ]
T6219 10053-10062 RB denotes Therefore
T6220 10062-10063 -COMMA- denotes ,
T6221 10064-10069 NN denotes Bcl10
T6222 10070-10080 NN denotes activation
T6223 10081-10084 VB denotes was
T6224 10085-10094 VB denotes evaluated
T6225 10095-10097 IN denotes in
T6226 10098-10102 CC denotes both
T6227 10103-10110 NN denotes control
T6228 10111-10114 CC denotes and
T6229 10115-10118 NN denotes PMA
T6230 10119-10129 JJ denotes stimulated
T6231 10130-10135 NN denotes cells
T6232 10136-10141 IN denotes after
T6233 10142-10144 CD denotes 10
T6234 10145-10148 NN denotes min
T6235 10148-10149 -COMMA- denotes ,
T6236 10150-10151 CD denotes 1
T6237 10152-10153 NN denotes h
T6238 10153-10154 -COMMA- denotes ,
T6239 10155-10156 CD denotes 6
T6240 10157-10158 NN denotes h
T6241 10158-10159 -COMMA- denotes ,
T6242 10160-10163 CC denotes and
T6243 10164-10166 CD denotes 24
T6244 10167-10168 NN denotes h
T6245 10169-10174 VB denotes using
T6246 10175-10182 JJ denotes western
T6247 10183-10187 NN denotes blot
T6248 10188-10196 NN denotes analysis
T6249 10198-10201 DT denotes The
T6250 10202-10207 NN denotes Bcl10
T6251 10208-10214 NN denotes levels
T6252 10215-10224 VB denotes decreased
T6253 10225-10234 VB denotes following
T6254 10235-10244 NN denotes treatment
T6255 10245-10249 IN denotes with
T6256 10250-10253 NN denotes PMA
T6257 10253-10254 -COMMA- denotes ,
T6258 10255-10260 IN denotes while
T6259 10261-10263 IN denotes in
T6260 10264-10271 NN denotes control
T6261 10272-10277 NN denotes cells
T6262 10277-10278 -COMMA- denotes ,
T6263 10279-10284 NN denotes Bcl10
T6264 10285-10293 VB denotes returned
T6265 10294-10296 TO denotes to
T6266 10297-10303 JJ denotes higher
T6267 10304-10310 NN denotes levels
T6268 10311-10313 IN denotes by
T6269 10314-10316 CD denotes 24
T6270 10317-10318 NN denotes h
T6271 10319-10320 -LRB- denotes (
T6272 10320-10326 NN denotes figure
T6273 10327-10329 NN denotes 7c
T6274 10329-10330 -RRB- denotes )
T6275 10332-10336 DT denotes This
T6276 10337-10345 VB denotes suggests
T6277 10346-10350 IN denotes that
T6278 10351-10356 NN denotes Bcl10
T6279 10357-10359 VB denotes is
T6280 10360-10368 VB denotes involved
T6281 10369-10371 IN denotes in
T6282 10372-10375 DT denotes the
T6283 10376-10379 NN denotes PMA
T6284 10380-10389 JJ denotes dependent
T6285 10390-10400 NN denotes inhibition
T6286 10401-10403 IN denotes of
T6287 10404-10409 NN denotes NF-κB
T6288 10410-10420 NN denotes activation
T15150 1229-1233 NN denotes AP-1
T15151 1234-1244 NN denotes activation
T15152 1245-1254 VB denotes following
T15153 1255-1264 JJ denotes long-term
T15154 1265-1273 NN denotes exposure
T15155 1274-1276 IN denotes of
T15156 1277-1283 NN denotes Jurkat
T15157 1284-1291 NN denotes T-cells
T15158 1292-1294 TO denotes to
T15159 1295-1298 NN denotes PMA
T15160 1300-1306 NN denotes Jurkat
T15161 1307-1314 NN denotes T-cells
T15162 1315-1319 VB denotes were
T15163 1320-1331 VB denotes transfected
T15164 1332-1336 IN denotes with
T15165 1337-1347 NN denotes luciferase
T15166 1348-1356 NN denotes reporter
T15167 1357-1365 NN denotes plasmids
T15168 1366-1376 VB denotes containing
T15169 1377-1380 DT denotes the
T15170 1381-1385 NN denotes AP-1
T15171 1386-1399 NN denotes cis-elements.
T15172 1400-1401 -LRB- denotes (
T15173 1401-1402 NN denotes A
T15174 1402-1403 -RRB- denotes )
T15175 1404-1418 JJ denotes Time-dependent
T15176 1419-1423 NN denotes AP-1
T15177 1424-1434 NN denotes activation
T15178 1435-1437 IN denotes in
T15179 1438-1446 NN denotes response
T15180 1447-1449 TO denotes to
T15181 1450-1454 NN denotes PMA.
T15182 1455-1456 -LRB- denotes (
T15183 1456-1457 NN denotes B
T15184 1457-1458 -RRB- denotes )
T15185 1459-1461 NN denotes HK
T15186 1462-1464 FW denotes E.
T15187 1465-1469 FW denotes coli
T15188 1470-1474 VB denotes does
T15189 1475-1478 RB denotes not
T15190 1479-1487 VB denotes activate
T15191 1488-1493 NN denotes AP-1.
T15192 1494-1495 -LRB- denotes (
T15193 1495-1496 NN denotes C
T15194 1496-1497 -RRB- denotes )
T15195 1498-1512 JJ denotes Dose-dependent
T15196 1513-1523 NN denotes activation
T15197 1524-1526 IN denotes of
T15198 1527-1531 NN denotes AP-1
T15199 1532-1536 VB denotes were
T15200 1537-1546 VB denotes performed
T15201 1547-1552 VB denotes using
T15202 1553-1556 NN denotes PMA
T15203 1557-1562 RB denotes alone
T15204 1563-1564 -LRB- denotes (
T15205 1564-1568 JJ denotes grey
T15206 1569-1573 NN denotes bars
T15207 1573-1574 -RRB- denotes )
T15208 1575-1578 CC denotes and
T15209 1579-1581 IN denotes in
T15210 1582-1593 NN denotes combination
T15211 1594-1598 IN denotes with
T15212 1599-1606 NN denotes calcium
T15213 1607-1616 NN denotes ionophore
T15214 1617-1618 -LRB- denotes (
T15215 1618-1621 NN denotes CaI
T15216 1622-1625 CD denotes 955
T15217 1626-1628 NN denotes μM
T15218 1628-1629 -COMMA- denotes ,
T15219 1630-1635 JJ denotes black
T15220 1636-1640 NN denotes bars
T15221 1640-1641 -RRB- denotes )
T15222 1641-1642 -LRB- denotes .
T15223 1643-1644 NN denotes (
T15224 1644-1645 -RRB- denotes D
T15225 1645-1651 JJ denotes ) TCR-
T15226 1651-1660 JJ denotes /- defici
T15227 1660-1665 NN denotes ent c
T15228 1665-1674 VB denotes ells resp
T15229 1674-1676 TO denotes on
T15230 1676-1679 NN denotes ded
T15231 1680-1681 -LRB- denotes t
T15232 1681-1684 CD denotes o P
T15233 1684-1686 NN denotes MA
T15234 1687-1688 -RRB- denotes (
T15235 1688-1690 IN denotes 16
T15236 1690-1703 VB denotes 2 nM) by up-r
T15237 1703-1707 NN denotes egul
T15238 1707-1715 NN denotes ating AP
T15239 1728-1739 JJ denotes Statistical
T15240 1740-1752 NN denotes significance
T15241 1753-1757 IN denotes from
T15242 1758-1761 DT denotes the
T15243 1762-1769 NN denotes control
T15244 1770-1773 VB denotes was
T15245 1774-1784 VB denotes determined
T15246 1785-1790 VB denotes using
T15247 1791-1798 NN denotes Student
T15248 1798-1800 POS denotes 's
T15249 1801-1808 NN denotes t-test.
T15250 1809-1810 -LRB- denotes (
T15251 1810-1811 NN denotes n
T15252 1812-1813 SYM denotes =
T15253 1814-1815 CD denotes 4
T15254 1815-1816 -RRB- denotes )
T15255 1818-1826 NN denotes Controls
T15256 1827-1831 VB denotes were
T15257 1832-1843 RB denotes arbitrarily
T15258 1844-1847 VB denotes set
T15259 1848-1850 TO denotes to
T15260 1851-1852 CD denotes 1
T15425 2645-2650 NN denotes NF-κB
T15426 2651-2666 NN denotes down-regulation
T15427 2667-2669 IN denotes by
T15428 2670-2673 NN denotes PMA
T15429 2674-2677 CC denotes and
T15430 2678-2691 NN denotes up-regulation
T15431 2692-2694 IN denotes by
T15432 2695-2699 NN denotes heat
T15433 2700-2706 VB denotes killed
T15434 2707-2709 FW denotes E.
T15435 2710-2714 FW denotes coli
T15436 2715-2721 NN denotes MG1655
T15437 2722-2731 VB denotes following
T15438 2732-2741 JJ denotes long-term
T15439 2742-2753 NN denotes stimulation
T15440 2755-2767 NN denotes Transfection
T15441 2768-2770 IN denotes of
T15442 2771-2777 NN denotes Jurkat
T15443 2778-2785 NN denotes T-cells
T15444 2786-2789 VB denotes was
T15445 2790-2799 VB denotes performed
T15446 2800-2805 VB denotes using
T15447 2806-2816 NN denotes luciferase
T15448 2817-2825 NN denotes reporter
T15449 2826-2834 NN denotes plasmids
T15450 2835-2845 VB denotes containing
T15451 2846-2851 NN denotes NF-κB
T15452 2852-2865 NN denotes cis-elements.
T15453 2866-2867 -LRB- denotes (
T15454 2867-2868 NN denotes A
T15455 2868-2869 -RRB- denotes )
T15456 2870-2884 JJ denotes Time-dependent
T15457 2885-2896 NN denotes stimulation
T15458 2897-2899 IN denotes of
T15459 2900-2906 NN denotes Jurkat
T15460 2907-2914 NN denotes T-cells
T15461 2915-2920 VB denotes using
T15462 2921-2924 NN denotes PMA
T15463 2926-2931 NN denotes NF-κB
T15464 2932-2942 NN denotes activation
T15465 2943-2946 VB denotes was
T15466 2947-2956 VB denotes evaluated
T15467 2957-2962 VB denotes using
T15468 2963-2965 NNP denotes HK
T15469 2966-2968 NNP denotes E.
T15470 2969-2973 NNP denotes coli
T15471 2974-2976 IN denotes in
T15472 2977-2978 DT denotes a
T15473 2979-2980 -LRB- denotes (
T15474 2980-2981 NN denotes B
T15475 2981-2982 -RRB- denotes )
T15476 2983-2988 NN denotes dose-
T15477 2989-2992 CC denotes and
T15478 2993-2994 -LRB- denotes (
T15479 2994-2995 NN denotes C
T15480 2995-2996 -RRB- denotes )
T15481 2997-3011 JJ denotes time-dependant
T15482 3012-3018 NN denotes manner
T15483 3020-3027 NN denotes Calcium
T15484 3028-3037 NN denotes ionophore
T15485 3038-3047 VB denotes increased
T15486 3048-3053 NN denotes NF-κB
T15487 3054-3062 NN denotes activity
T15488 3063-3072 VB denotes following
T15489 3073-3076 NN denotes PMA
T15490 3077-3085 NN denotes exposure
T15491 3086-3087 -LRB- denotes (
T15492 3087-3088 NN denotes E
T15493 3088-3089 -RRB- denotes )
T15494 3090-3093 CC denotes and
T15495 3094-3102 VB denotes resulted
T15496 3103-3105 IN denotes in
T15497 3106-3107 DT denotes a
T15498 3108-3116 JJ denotes negative
T15499 3117-3127 NN denotes regulation
T15500 3128-3130 IN denotes in
T15501 3131-3139 NN denotes response
T15502 3140-3142 TO denotes to
T15503 3143-3145 NN denotes HK
T15504 3146-3148 FW denotes E.
T15505 3149-3153 FW denotes coli
T15506 3154-3165 NN denotes stimulation
T15507 3166-3167 -LRB- denotes (
T15508 3167-3168 NN denotes D
T15509 3168-3169 -RRB- denotes )
T15510 3171-3182 JJ denotes Statistical
T15511 3183-3195 NN denotes significance
T15512 3196-3200 IN denotes from
T15513 3201-3204 DT denotes the
T15514 3205-3212 NN denotes control
T15515 3213-3216 VB denotes was
T15516 3217-3227 VB denotes determined
T15517 3228-3233 VB denotes using
T15518 3234-3241 NN denotes Student
T15519 3241-3243 POS denotes 's
T15520 3244-3251 NN denotes t-test.
T15521 3252-3253 -LRB- denotes (
T15522 3253-3254 NN denotes n
T15523 3255-3256 SYM denotes =
T15524 3257-3258 CD denotes 4
T15525 3258-3259 -RRB- denotes )
T15526 3261-3269 NN denotes Controls
T15527 3270-3274 VB denotes were
T15528 3275-3286 RB denotes arbitrarily
T15529 3287-3290 VB denotes set
T15530 3291-3293 TO denotes to
T15531 3294-3295 CD denotes 1
T15704 4600-4605 NN denotes CXCL8
T15705 4605-4606 -COMMA- denotes ,
T15706 4607-4611 NN denotes IL-6
T15707 4612-4615 CC denotes and
T15708 4616-4619 NN denotes TNF
T15709 4620-4630 NN denotes expression
T15710 4631-4640 VB denotes following
T15711 4641-4650 JJ denotes long-term
T15712 4651-4662 NN denotes stimulation
T15713 4663-4667 IN denotes with
T15714 4668-4671 NN denotes PMA
T15715 4673-4679 NN denotes Jurkat
T15716 4680-4687 NN denotes T-cells
T15717 4688-4692 VB denotes were
T15718 4693-4699 RB denotes either
T15719 4700-4707 VB denotes treated
T15720 4708-4712 IN denotes with
T15721 4713-4718 NN denotes media
T15722 4719-4720 -LRB- denotes (
T15723 4720-4725 JJ denotes white
T15724 4726-4730 NN denotes bars
T15725 4730-4731 -RRB- denotes )
T15726 4732-4734 CC denotes or
T15727 4735-4745 VB denotes stimulated
T15728 4746-4750 IN denotes with
T15729 4751-4754 NN denotes PMA
T15730 4755-4756 -LRB- denotes (
T15731 4756-4761 JJ denotes black
T15732 4762-4766 NN denotes bars
T15733 4766-4767 -RRB- denotes )
T15734 4768-4771 CC denotes and
T15735 4772-4781 VB denotes incubated
T15736 4782-4785 IN denotes for
T15737 4786-4787 CD denotes 1
T15738 4788-4789 NN denotes h
T15739 4789-4790 -COMMA- denotes ,
T15740 4791-4792 CD denotes 2
T15741 4793-4794 NN denotes h
T15742 4794-4795 -COMMA- denotes ,
T15743 4796-4797 CD denotes 6
T15744 4798-4799 NN denotes h
T15745 4800-4803 CC denotes and
T15746 4804-4806 CD denotes 24
T15747 4807-4808 NN denotes h
T15748 4810-4814 JJ denotes Aged
T15749 4815-4820 NN denotes media
T15750 4821-4824 VB denotes was
T15751 4825-4830 VB denotes added
T15752 4831-4840 VB denotes following
T15753 4841-4845 DT denotes each
T15754 4846-4860 NN denotes centrifugation
T15755 4861-4865 NN denotes step
T15756 4866-4880 JJ denotes representative
T15757 4881-4883 TO denotes to
T15758 4884-4887 DT denotes the
T15759 4888-4899 NN denotes stimulation
T15760 4900-4904 NN denotes time
T15761 4905-4906 -LRB- denotes (
T15762 4906-4909 VB denotes see
T15763 4910-4919 NNP denotes Materials
T15764 4920-4923 CC denotes and
T15765 4924-4931 NN denotes methods
T15766 4931-4932 -RRB- denotes )
T15767 4934-4942 NN denotes Cytokine
T15768 4943-4949 NN denotes levels
T15769 4950-4951 -LRB- denotes (
T15770 4951-4952 NN denotes A
T15771 4952-4953 -RRB- denotes )
T15772 4954-4959 NN denotes CXCL8
T15773 4959-4960 -COMMA- denotes ,
T15774 4961-4962 -LRB- denotes (
T15775 4962-4963 NN denotes B
T15776 4963-4964 -RRB- denotes )
T15777 4965-4969 NN denotes IL-6
T15778 4970-4973 CC denotes and
T15779 4974-4975 -LRB- denotes (
T15780 4975-4976 NN denotes C
T15781 4976-4977 -RRB- denotes )
T15782 4978-4981 NN denotes TNF
T15783 4982-4986 VB denotes were
T15784 4987-4995 VB denotes detected
T15785 4996-4998 IN denotes by
T15786 4999-5004 NN denotes ELISA
T15787 5006-5017 JJ denotes Statistical
T15788 5018-5030 NN denotes significance
T15789 5031-5035 IN denotes from
T15790 5036-5039 DT denotes the
T15791 5040-5047 NN denotes control
T15792 5048-5051 VB denotes was
T15793 5052-5062 VB denotes determined
T15794 5063-5068 VB denotes using
T15795 5069-5076 NN denotes Student
T15796 5076-5078 POS denotes 's
T15797 5079-5086 NN denotes t-test.
T15798 5087-5088 -LRB- denotes (
T15799 5088-5089 NN denotes n
T15800 5090-5091 SYM denotes =
T15801 5092-5093 CD denotes 3
T15802 5093-5094 -RRB- denotes )
T15991 6306-6316 NN denotes Inhibition
T15992 6317-6319 IN denotes of
T15993 6320-6325 NN denotes NF-κB
T15994 6326-6334 NN denotes activity
T15995 6335-6337 IN denotes by
T15996 6338-6341 NN denotes NAI
T15997 6343-6349 NN denotes Jurkat
T15998 6350-6357 NN denotes T-cells
T15999 6358-6362 VB denotes were
T16000 6363-6374 VB denotes transfected
T16001 6375-6379 IN denotes with
T16002 6380-6390 NN denotes luciferase
T16003 6391-6399 NN denotes reporter
T16004 6400-6408 NN denotes plasmids
T16005 6409-6419 VB denotes containing
T16006 6420-6426 CC denotes either
T16007 6427-6432 NN denotes NF-κB
T16008 6433-6435 CC denotes or
T16009 6436-6440 NN denotes AP-1
T16010 6441-6451 JJ denotes cis-acting
T16011 6452-6460 NN denotes elements
T16012 6462-6465 DT denotes The
T16013 6466-6471 NN denotes cells
T16014 6472-6476 VB denotes were
T16015 6477-6486 VB denotes incubated
T16016 6487-6491 IN denotes with
T16017 6492-6497 NN denotes NF-κB
T16018 6498-6508 NN denotes activation
T16019 6509-6518 NN denotes inhibitor
T16020 6519-6520 -LRB- denotes (
T16021 6520-6523 NN denotes NAI
T16022 6523-6524 -RRB- denotes )
T16023 6525-6528 IN denotes for
T16024 6529-6530 CD denotes 1
T16025 6531-6532 NN denotes h
T16026 6533-6541 VB denotes followed
T16027 6542-6544 IN denotes by
T16028 6545-6556 NN denotes stimulation
T16029 6557-6561 IN denotes with
T16030 6562-6565 NN denotes PMA
T16031 6566-6567 -LRB- denotes (
T16032 6567-6570 CD denotes 162
T16033 6571-6573 NN denotes nM
T16034 6573-6574 -COMMA- denotes ,
T16035 6575-6576 NN denotes A
T16036 6577-6580 CC denotes and
T16037 6581-6582 NN denotes C
T16038 6582-6583 -RRB- denotes )
T16039 6584-6586 CC denotes or
T16040 6587-6589 NN denotes HK
T16041 6590-6592 FW denotes E.
T16042 6593-6597 FW denotes coli
T16043 6598-6599 -LRB- denotes (
T16044 6599-6600 CD denotes 5
T16045 6601-6602 NN denotes ×
T16046 6603-6606 CD denotes 107
T16047 6607-6613 NNP denotes CFU/ml
T16048 6613-6614 -COMMA- denotes ,
T16049 6615-6616 NN denotes B
T16050 6617-6620 CC denotes and
T16051 6621-6622 NN denotes D
T16052 6622-6623 -RRB- denotes )
T16053 6624-6627 IN denotes for
T16054 6628-6630 CD denotes 24
T16055 6631-6633 NN denotes h.
T16056 6634-6635 -LRB- denotes (
T16057 6635-6636 NN denotes A
T16058 6636-6637 -COMMA- denotes ,
T16059 6638-6639 NN denotes B
T16060 6639-6640 -RRB- denotes )
T16061 6641-6646 NN denotes NF-κB
T16062 6646-6647 -COMMA- denotes ,
T16063 6648-6651 CC denotes but
T16064 6652-6655 RB denotes not
T16065 6656-6657 -LRB- denotes (
T16066 6657-6658 NN denotes C
T16067 6658-6659 -COMMA- denotes ,
T16068 6660-6661 NN denotes D
T16069 6661-6662 -RRB- denotes )
T16070 6663-6667 NN denotes AP-1
T16071 6668-6671 VB denotes was
T16072 6672-6681 VB denotes inhibited
T16073 6683-6694 JJ denotes Statistical
T16074 6695-6707 NN denotes significance
T16075 6708-6712 IN denotes from
T16076 6713-6716 DT denotes the
T16077 6717-6725 JJ denotes positive
T16078 6726-6733 NN denotes control
T16079 6734-6735 -LRB- denotes (
T16080 6735-6741 NN denotes PMA/HK
T16081 6742-6744 FW denotes E.
T16082 6745-6749 FW denotes coli
T16083 6749-6750 -RRB- denotes )
T16084 6751-6754 VB denotes was
T16085 6755-6765 VB denotes determined
T16086 6766-6771 VB denotes using
T16087 6772-6779 NN denotes Student
T16088 6779-6781 POS denotes 's
T16089 6782-6789 NN denotes t-test.
T16090 6790-6791 -LRB- denotes (
T16091 6791-6792 NN denotes n
T16092 6793-6794 SYM denotes =
T16093 6795-6796 CD denotes 4
T16094 6796-6797 -RRB- denotes )
T16095 6799-6807 NN denotes Controls
T16096 6808-6812 VB denotes were
T16097 6813-6816 VB denotes set
T16098 6817-6819 TO denotes to
T16099 6820-6821 CD denotes 1
T16538 8737-8748 NN denotes Involvement
T16539 8749-8751 IN denotes of
T16540 8752-8755 NN denotes PKC
T16541 8756-8759 CC denotes and
T16542 8760-8763 NN denotes JNK
T16543 8764-8766 IN denotes in
T16544 8767-8775 NN denotes cytokine
T16545 8776-8786 NN denotes expression
T16546 8788-8794 NN denotes Jurkat
T16547 8795-8802 NN denotes T-cells
T16548 8803-8807 VB denotes were
T16549 8808-8817 VB denotes incubated
T16550 8818-8822 IN denotes with
T16551 8823-8827 NN denotes PKC-
T16552 8828-8831 CC denotes and
T16553 8832-8835 NN denotes JNK
T16554 8836-8846 NN denotes inhibitors
T16555 8847-8850 IN denotes for
T16556 8851-8852 CD denotes 1
T16557 8853-8854 NN denotes h
T16558 8855-8863 VB denotes followed
T16559 8864-8866 IN denotes by
T16560 8867-8878 NN denotes stimulation
T16561 8879-8883 IN denotes with
T16562 8884-8887 NN denotes PMA
T16563 8888-8889 -LRB- denotes (
T16564 8889-8892 CD denotes 162
T16565 8893-8895 NN denotes nM
T16566 8895-8896 -RRB- denotes )
T16567 8897-8900 IN denotes for
T16568 8901-8903 CD denotes 24
T16569 8904-8906 NN denotes h.
T16570 8907-8908 -LRB- denotes (
T16571 8908-8909 NN denotes A
T16572 8909-8910 -RRB- denotes )
T16573 8911-8916 NN denotes CXCL8
T16574 8917-8927 NN denotes expression
T16575 8928-8931 VB denotes was
T16576 8932-8941 VB denotes inhibited
T16577 8942-8944 IN denotes in
T16578 8945-8946 DT denotes a
T16579 8947-8961 JJ denotes dose-dependent
T16580 8962-8968 NN denotes manner
T16581 8969-8971 IN denotes by
T16582 8972-8976 CC denotes both
T16583 8977-8988 NN denotes inhibitors.
T16584 8989-8990 -LRB- denotes (
T16585 8990-8991 NN denotes B
T16586 8991-8992 -RRB- denotes )
T16587 8993-8998 NN denotes JNK-I
T16588 8999-9007 VB denotes revealed
T16589 9008-9009 DT denotes a
T16590 9010-9018 JJ denotes stronger
T16591 9019-9029 JJ denotes inhibitory
T16592 9030-9036 NN denotes effect
T16593 9037-9039 IN denotes on
T16594 9040-9044 NN denotes IL-6
T16595 9045-9055 NN denotes expression
T16596 9056-9060 IN denotes than
T16597 9061-9064 DT denotes the
T16598 9065-9071 NN denotes PKC-I.
T16599 9072-9073 -LRB- denotes (
T16600 9073-9074 NN denotes C
T16601 9074-9075 -RRB- denotes )
T16602 9076-9079 NN denotes TNF
T16603 9080-9090 NN denotes expression
T16604 9091-9094 VB denotes was
T16605 9095-9098 RB denotes not
T16606 9099-9107 VB denotes affected
T16607 9108-9110 IN denotes by
T16608 9111-9117 DT denotes either
T16609 9118-9127 NN denotes inhibitor
T16610 9129-9140 JJ denotes Statistical
T16611 9141-9153 NN denotes significance
T16612 9154-9158 IN denotes from
T16613 9159-9162 DT denotes the
T16614 9163-9171 JJ denotes positive
T16615 9172-9179 NN denotes control
T16616 9180-9181 -LRB- denotes (
T16617 9181-9184 NN denotes PMA
T16618 9184-9185 -RRB- denotes )
T16619 9186-9189 VB denotes was
T16620 9190-9200 VB denotes determined
T16621 9201-9206 VB denotes using
T16622 9207-9214 NN denotes Student
T16623 9214-9216 POS denotes 's
T16624 9217-9224 NN denotes t-test.
T16625 9225-9226 -LRB- denotes (
T16626 9226-9227 NN denotes n
T16627 9228-9229 SYM denotes =
T16628 9230-9231 CD denotes 3
T16629 9231-9232 -RRB- denotes )
T16839 10432-10437 NN denotes NF-κB
T16840 10438-10448 NN denotes inhibition
T16841 10449-10451 IN denotes by
T16842 10452-10455 NN denotes PMA
T16843 10456-10466 VB denotes correlated
T16844 10467-10469 TO denotes to
T16845 10470-10483 JJ denotes PKC-dependent
T16846 10484-10489 NN denotes Bcl10
T16847 10490-10501 NN denotes degradation
T16848 10503-10509 NN denotes Levels
T16849 10510-10512 IN denotes of
T16850 10513-10526 JJ denotes intracellular
T16851 10527-10534 NN denotes protein
T16852 10535-10539 VB denotes were
T16853 10540-10548 VB denotes assessed
T16854 10549-10558 VB denotes following
T16855 10559-10561 CD denotes 24
T16856 10562-10563 NN denotes h
T16857 10564-10575 NN denotes stimulation
T16858 10576-10580 IN denotes with
T16859 10581-10584 NN denotes PMA
T16860 10585-10586 -LRB- denotes (
T16861 10586-10589 CD denotes 162
T16862 10590-10592 NN denotes nM
T16863 10592-10593 -RRB- denotes )
T16864 10594-10596 CC denotes or
T16865 10597-10599 NN denotes HK
T16866 10600-10602 FW denotes E.
T16867 10603-10607 FW denotes coli
T16868 10608-10609 -LRB- denotes (
T16869 10609-10610 CD denotes 5
T16870 10611-10612 NN denotes ×
T16871 10613-10616 CD denotes 107
T16872 10617-10623 NNP denotes CFU/ml
T16873 10623-10624 -RRB- denotes )
T16874 10624-10625 -LRB- denotes .
T16875 10626-10627 NN denotes (
T16876 10627-10628 -RRB- denotes A
T16877 10628-10639 NN denotes ) Phospho-P
T16878 10639-10648 VB denotes KC increa
T16879 10648-10650 IN denotes se
T16880 10650-10658 NN denotes d in res
T16881 10658-10660 TO denotes po
T16882 10660-10663 NN denotes nse
T16883 10664-10667 CC denotes to
T16884 10667-10669 NN denotes PM
T16885 10669-10671 FW denotes A
T16886 10671-10675 FW denotes and
T16887 10675-10687 NN denotes HK E. coli s
T16888 10687-10688 -LRB- denotes t
T16889 10688-10689 NN denotes i
T16890 10689-10690 -RRB- denotes m
T16891 10690-10693 NN denotes ula
T16892 10693-10702 VB denotes tion. (B)
T16893 10703-10712 VB denotes IκB decre
T16894 10712-10723 NN denotes ased follow
T16895 10723-10727 IN denotes ing
T16896 10727-10729 NN denotes st
T16897 10729-10731 FW denotes im
T16898 10731-10735 FW denotes ulat
T16899 10735-10745 VB denotes ion with H
T16900 10745-10750 NN denotes K E.
T16901 10750-10761 NN denotes coli indica
T16902 10761-10762 -LRB- denotes t
T16903 10762-10763 NN denotes i
T16904 10763-10764 -RRB- denotes n
T16905 10764-10769 NN denotes g NF-
T16906 10769-10779 NN denotes κB activat
T16907 10779-10782 VB denotes ion
T16908 10782-10791 VB denotes . (C) Bcl
T16909 10791-10800 VB denotes 10 activa
T16910 10800-10809 JJ denotes tion was
T16911 10809-10820 NN denotes inhibited f
T16912 10820-10824 IN denotes ollo
T16913 10824-10827 NN denotes win
T16914 10827-10828 -COMMA- denotes g
T16915 10829-10834 WDT denotes long-
T16916 10834-10842 VB denotes term sti
T16917 10842-10845 DT denotes mul
T16918 10845-10855 JJ denotes ation with
T16919 10856-10862 NN denotes PMA, w
T16920 10862-10864 IN denotes hi
T16921 10864-10867 NN denotes ch
T16922 10867-10869 IN denotes ex
T16923 10869-10874 NN denotes plain
T16924 10874-10885 NN denotes s the inhib
T16925 10885-10892 NN denotes itory e
T16926 10892-10895 VB denotes ffe
T16927 10895-10899 VB denotes ct o
T16928 10899-10901 IN denotes f
T16929 10901-10902 DT denotes P
T16930 10902-10909 NN denotes MA on N
T16931 10909-10917 NN denotes F-κB act
T16932 10917-10918 -LRB- denotes i
T16933 10918-10919 NN denotes v
T16934 10919-10920 SYM denotes a
T16935 10920-10921 CD denotes t
T16936 10921-10922 -RRB- denotes i
T17025 5105-5111 NN denotes Jurkat
T17026 5112-5119 NN denotes T-cells
T17027 5120-5124 VB denotes were
T17028 5125-5135 VB denotes stimulated
T17029 5136-5140 IN denotes with
T17030 5141-5144 CD denotes 162
T17031 5145-5147 NN denotes nM
T17032 5148-5151 NN denotes PMA
T17033 5152-5155 CC denotes and
T17034 5156-5157 CD denotes 5
T17035 5158-5159 NN denotes ×
T17036 5160-5163 CD denotes 107
T17037 5164-5170 NNP denotes CFU/ml
T17038 5171-5173 NNP denotes HK
T17039 5174-5176 NNP denotes E.
T17040 5177-5181 NNP denotes coli
T17041 5182-5185 IN denotes for
T17042 5186-5188 CD denotes 24
T17043 5189-5190 NN denotes h
T17075 9243-9249 NN denotes Jurkat
T17076 9250-9257 NN denotes T-cells
T17077 9258-9262 VB denotes were
T17078 9263-9270 VB denotes treated
T17079 9271-9275 IN denotes with
T17080 9276-9278 CD denotes 10
T17081 9279-9281 NN denotes nM
T17082 9282-9285 NN denotes NAI
T17083 9285-9286 -COMMA- denotes ,
T17084 9287-9289 CD denotes 10
T17085 9290-9292 NN denotes μM
T17086 9293-9298 NN denotes JNK-I
T17087 9299-9303 NN denotes or10
T17088 9304-9306 NN denotes nM
T17089 9307-9312 NN denotes PKC-I
T17090 9313-9316 IN denotes for
T17091 9317-9318 CD denotes 2
T17092 9319-9320 NN denotes h
T17093 9321-9329 VB denotes followed
T17094 9330-9332 IN denotes by
T17095 9333-9342 NN denotes induction
T17096 9343-9347 IN denotes with
T17097 9348-9351 CD denotes 162
T17098 9352-9354 NN denotes nM
T17099 9355-9358 NN denotes PMA
T17100 9359-9362 IN denotes for
T17101 9363-9365 CD denotes 24
T17102 9366-9367 NN denotes h
R2767 T3423 T3422 arg1Of activation,NF-κB
R2768 T3426 T3424 arg1Of factors,The
R2769 T3426 T3425 arg1Of factors,transcription
R2770 T3427 T3428 arg1Of NF-κB,and
R2771 T3428 T3426 arg1Of and,factors
R2772 T3428 T3430 arg1Of and,play
R2773 T3428 T3441 arg1Of and,inducing
R2774 T3429 T3428 arg2Of AP-1,and
R2775 T3430 T3433 arg1Of play,in
R2776 T3430 T3440 arg1Of play,by
R2777 T3432 T3430 arg2Of roles,play
R2778 T3432 T3431 arg1Of roles,key
R2779 T3435 T3433 arg2Of initiation,in
R2780 T3435 T3434 arg1Of initiation,the
R2781 T3435 T3436 arg1Of initiation,of
R2782 T3439 T3436 arg2Of response,of
R2783 T3439 T3437 arg1Of response,an
R2784 T3439 T3438 arg1Of response,inflammatory
R2785 T3441 T3440 arg2Of inducing,by
R2786 T3443 T3444 arg1Of expression,and
R2787 T3444 T3441 arg2Of and,inducing
R2788 T3444 T3442 arg1Of and,the
R2789 T3444 T3446 arg1Of and,of
R2790 T3445 T3444 arg2Of secretion,and
R2791 T3447 T3448 arg1Of chemokines,and
R2792 T3448 T3446 arg2Of and,of
R2793 T3448 T3450 arg1Of and,that
R2794 T3448 T3451 arg1Of and,attract
R2795 T3448 T3453 arg1Of and,activate
R2796 T3449 T3448 arg2Of cytokines,and
R2797 T3451 T3452 arg1Of attract,and
R2798 T3453 T3452 arg2Of activate,and
R2799 T3455 T3451 arg2Of cells,attract
R2800 T3455 T3453 arg2Of cells,activate
R2801 T3455 T3454 arg1Of cells,immune
R2802 T3461 T3459 arg1Of pathways,signal
R2803 T3461 T3460 arg1Of pathways,transduction
R2804 T3461 T3462 arg1Of pathways,and
R2805 T3462 T3458 arg1Of and,the
R2806 T3462 T3471 arg1Of and,is
R2807 T3462 T3474 arg2Of and,elucidated
R2808 T3466 T3462 arg2Of induction,and
R2809 T3466 T3463 arg1Of induction,subsequent
R2810 T3466 T3464 arg1Of induction,inflammatory
R2811 T3466 T3465 arg1Of induction,cytokine
R2812 T3466 T3467 arg1Of induction,by
R2813 T3470 T3467 arg2Of factors,by
R2814 T3470 T3468 arg1Of factors,these
R2815 T3470 T3469 arg1Of factors,transcription
R2816 T3474 T3456 arg1Of elucidated,However
R2817 T3474 T3457 arg1Of elucidated,","
R2818 T3474 T3471 arg2Of elucidated,is
R2819 T3474 T3472 arg1Of elucidated,not
R2820 T3474 T3473 arg1Of elucidated,fully
R2821 T3477 T3475 arg1Of study,The
R2822 T3477 T3476 arg1Of study,present
R2823 T3477 T3478 arg1Of study,is
R2824 T3477 T3479 arg2Of study,aimed
R2825 T3479 T3478 arg2Of aimed,is
R2826 T3479 T3480 arg1Of aimed,at
R2827 T3481 T3480 arg2Of determining,at
R2828 T3483 T3481 arg2Of involvement,determining
R2829 T3483 T3482 arg1Of involvement,the
R2830 T3483 T3484 arg1Of involvement,of
R2831 T3483 T3488 arg1Of involvement,in
R2832 T3485 T3486 arg1Of AP-1,and
R2833 T3486 T3484 arg2Of and,of
R2834 T3487 T3486 arg2Of NF-κB,and
R2835 T3490 T3491 arg1Of induction,and
R2836 T3491 T3488 arg2Of and,in
R2837 T3491 T3489 arg1Of and,cytokine
R2838 T3492 T3491 arg2Of regulation,and
R2839 T3494 T3493 arg1Of treatment,PMA
R2840 T3494 T3495 arg1Of treatment,resulted
R2841 T3494 T3506 arg1Of treatment,continued
R2842 T3494 T3508 arg1Of treatment,increase
R2843 T3495 T3496 arg1Of resulted,in
R2844 T3495 T3501 arg1Of resulted,after
R2845 T3495 T3505 arg1Of resulted,and
R2846 T3498 T3496 arg2Of up-regulation,in
R2847 T3498 T3497 arg1Of up-regulation,an
R2848 T3498 T3499 arg1Of up-regulation,of
R2849 T3500 T3499 arg2Of AP-1,of
R2850 T3504 T3501 arg2Of exposure,after
R2851 T3504 T3502 arg1Of exposure,2
R2852 T3504 T3503 arg1Of exposure,h
R2853 T3506 T3505 arg2Of continued,and
R2854 T3508 T3506 arg2Of increase,continued
R2855 T3508 T3507 arg1Of increase,to
R2856 T3508 T3509 arg1Of increase,throughout
R2857 T3512 T3509 arg2Of period,throughout
R2858 T3512 T3510 arg1Of period,the
R2859 T3512 T3511 arg1Of period,analysis
R2860 T3512 T3513 arg1Of period,(
R2861 T3515 T3513 arg2Of 1a,(
R2862 T3515 T3514 arg1Of 1a,figure
R2863 T3516 T3513 arg3Of ),(
R2864 T3520 T3517 arg1Of treatment,HK
R2865 T3520 T3518 arg1Of treatment,E.
R2866 T3520 T3519 arg1Of treatment,coli
R2867 T3520 T3521 arg1Of treatment,did
R2868 T3520 T3523 arg1Of treatment,affect
R2869 T3523 T3521 arg2Of affect,did
R2870 T3523 T3522 arg1Of affect,not
R2871 T3523 T3526 arg1Of affect,in
R2872 T3525 T3523 arg2Of activation,affect
R2873 T3525 T3524 arg1Of activation,AP-1
R2874 T3528 T3526 arg2Of T-cells,in
R2875 T3528 T3527 arg1Of T-cells,Jurkat
R2876 T3528 T3529 arg1Of T-cells,(
R2877 T3531 T3529 arg2Of 1b,(
R2878 T3531 T3530 arg1Of 1b,figure
R2879 T3532 T3529 arg3Of ),(
R2880 T3534 T3533 arg1Of determine,To
R2881 T3536 T3534 arg2Of involvement,determine
R2882 T3536 T3535 arg1Of involvement,the
R2883 T3536 T3537 arg1Of involvement,of
R2884 T3539 T3537 arg2Of pathways,of
R2885 T3539 T3538 arg2Of pathways,associated
R2886 T3541 T3542 arg1Of we,exposed
R2887 T3541 T3552 arg1Of we,observed
R2888 T3542 T3544 arg1Of exposed,to
R2889 T3542 T3547 arg1Of exposed,with
R2890 T3542 T3549 arg1Of exposed,without
R2891 T3542 T3551 arg1Of exposed,and
R2892 T3543 T3542 arg2Of cells,exposed
R2893 T3546 T3544 arg2Of ionophore,to
R2894 T3546 T3545 arg1Of ionophore,Ca2+
R2895 T3547 T3548 arg1Of with,or
R2896 T3549 T3548 arg2Of without,or
R2897 T3550 T3547 arg2Of PMA,with
R2898 T3550 T3549 arg2Of PMA,without
R2899 T3551 T3533 modOf and,To
R2900 T3551 T3540 arg1Of and,","
R2901 T3552 T3551 arg2Of observed,and
R2902 T3552 T3566 arg1Of observed,while
R2903 T3555 T3552 arg2Of involvement,observed
R2904 T3555 T3553 arg1Of involvement,a
R2905 T3555 T3554 arg1Of involvement,modest
R2906 T3555 T3556 arg1Of involvement,of
R2907 T3555 T3558 arg1Of involvement,in
R2908 T3557 T3556 arg2Of Ca2+,of
R2909 T3561 T3558 arg2Of activation,in
R2910 T3561 T3559 arg1Of activation,PMA-dependent
R2911 T3561 T3560 arg1Of activation,AP-1
R2912 T3561 T3562 arg1Of activation,(
R2913 T3564 T3562 arg2Of 1c,(
R2914 T3564 T3563 arg1Of 1c,figure
R2915 T3565 T3562 arg3Of ),(
R2916 T3567 T3568 arg1Of Ca2+,alone
R2917 T3567 T3569 arg1Of Ca2+,did
R2918 T3567 T3571 arg1Of Ca2+,alter
R2919 T3571 T3566 arg2Of alter,while
R2920 T3571 T3569 arg2Of alter,did
R2921 T3571 T3570 arg1Of alter,not
R2922 T3573 T3571 arg2Of activity,alter
R2923 T3573 T3572 arg1Of activity,AP-1
R2924 T3573 T3574 arg1Of activity,(
R2925 T3575 T3574 arg2Of data,(
R2926 T3575 T3577 arg2Of data,shown
R2927 T3577 T3576 arg1Of shown,not
R2928 T3578 T3574 arg3Of ),(
R2929 T3582 T3581 arg1Of activity,AP-1
R2930 T3582 T3583 arg1Of activity,decreased
R2931 T3582 T3591 arg1Of activity,exposed
R2932 T3583 T3579 arg1Of decreased,Furthermore
R2933 T3583 T3580 arg1Of decreased,","
R2934 T3583 T3584 arg1Of decreased,in
R2935 T3583 T3590 arg1Of decreased,when
R2936 T3589 T3584 arg2Of line,in
R2937 T3589 T3585 arg1Of line,a
R2938 T3589 T3586 arg1Of line,TCR-deficient
R2939 T3589 T3587 arg1Of line,Jurkat
R2940 T3589 T3588 arg1Of line,cell
R2941 T3591 T3590 arg2Of exposed,when
R2942 T3591 T3592 arg1Of exposed,to
R2943 T3591 T3594 arg1Of exposed,compared
R2944 T3593 T3592 arg2Of PMA,to
R2945 T3595 T3594 arg2Of to,compared
R2946 T3599 T3595 arg2Of line,to
R2947 T3599 T3596 arg1Of line,the
R2948 T3599 T3597 arg1Of line,parent
R2949 T3599 T3598 arg1Of line,cell
R2950 T3599 T3600 arg1Of line,indicating
R2951 T3599 T3611 arg1Of line,(
R2952 T3602 T3603 arg1Of regulation,of
R2953 T3602 T3605 arg1Of regulation,was
R2954 T3602 T3610 arg1Of regulation,dependent
R2955 T3604 T3603 arg2Of AP-1,of
R2956 T3605 T3600 arg2Of was,indicating
R2957 T3605 T3601 arg1Of was,that
R2958 T3605 T3607 arg1Of was,partially
R2959 T3607 T3606 arg1Of partially,only
R2960 T3609 T3608 arg1Of receptor,T-cell
R2961 T3610 T3605 arg2Of dependent,was
R2962 T3610 T3609 arg1Of dependent,receptor
R2963 T3613 T3611 arg2Of 1d,(
R2964 T3613 T3612 arg1Of 1d,figure
R2965 T3614 T3611 arg3Of ),(
R2966 T3616 T3615 arg1Of levels,NF-κB
R2967 T3616 T3617 arg1Of levels,showed
R2968 T3617 T3624 arg1Of showed,after
R2969 T3620 T3617 arg2Of increase,showed
R2970 T3620 T3618 arg1Of increase,a
R2971 T3620 T3619 arg1Of increase,transient
R2972 T3620 T3621 arg1Of increase,at
R2973 T3623 T3621 arg2Of min,at
R2974 T3623 T3622 arg1Of min,1
R2975 T3625 T3624 arg2Of exposure,after
R2976 T3625 T3626 arg1Of exposure,to
R2977 T3627 T3626 arg2Of PMA,to
R2978 T3627 T3628 arg1Of PMA,(
R2979 T3630 T3628 arg2Of 2a,(
R2980 T3630 T3629 arg1Of 2a,figure
R2981 T3631 T3628 arg3Of ),(
R2982 T3635 T3634 arg1Of h,1
R2983 T3635 T3644 arg1Of h,reaching
R2984 T3637 T3636 arg2Of exposure,after
R2985 T3637 T3643 arg2Of exposure,drop
R2986 T3640 T3638 arg1Of levels,the
R2987 T3640 T3639 arg1Of levels,NF-κB
R2988 T3640 T3641 arg1Of levels,began
R2989 T3640 T3643 arg1Of levels,drop
R2990 T3643 T3641 arg2Of drop,began
R2991 T3643 T3642 arg1Of drop,to
R2992 T3644 T3632 arg1Of reaching,However
R2993 T3644 T3633 arg1Of reaching,","
R2994 T3644 T3636 arg1Of reaching,after
R2995 T3644 T3648 arg1Of reaching,by
R2996 T3647 T3644 arg2Of levels,reaching
R2997 T3647 T3645 arg1Of levels,the
R2998 T3647 T3646 arg1Of levels,lowest
R2999 T3650 T3648 arg2Of h,by
R3000 T3650 T3649 arg1Of h,6
R3001 T3650 T3651 arg1Of h,","
R3002 T3650 T3652 arg2Of h,after
R3003 T3650 T3653 arg1Of h,which
R3004 T3654 T3655 arg1Of they,increased
R3005 T3655 T3652 arg1Of increased,after
R3006 T3655 T3656 arg1Of increased,again
R3007 T3655 T3657 arg1Of increased,by
R3008 T3659 T3657 arg2Of h,by
R3009 T3659 T3658 arg1Of h,24
R3010 T3660 T3661 arg1Of Exposure,of
R3011 T3660 T3664 arg1Of Exposure,to
R3012 T3660 T3668 arg1Of Exposure,resulted
R3013 T3663 T3661 arg2Of T-cells,of
R3014 T3663 T3662 arg1Of T-cells,Jurkat
R3015 T3666 T3664 arg2Of E.,to
R3016 T3666 T3665 arg1Of E.,HK
R3017 T3666 T3667 arg1Of E.,coli
R3018 T3668 T3669 arg1Of resulted,in
R3019 T3668 T3674 arg1Of resulted,","
R3020 T3668 T3675 arg1Of resulted,with
R3021 T3668 T3688 arg1Of resulted,CFU/ml
R3022 T3673 T3669 arg2Of activation,in
R3023 T3673 T3670 arg1Of activation,a
R3024 T3673 T3671 arg1Of activation,dose-dependent
R3025 T3673 T3672 arg1Of activation,NF-κB
R3026 T3678 T3675 arg2Of activity,with
R3027 T3678 T3676 arg1Of activity,the
R3028 T3678 T3677 arg1Of activity,highest
R3029 T3678 T3679 arg2Of activity,observed
R3030 T3679 T3675 arg3Of observed,with
R3031 T3679 T3680 arg1Of observed,at
R3032 T3683 T3680 arg2Of concentration,at
R3033 T3683 T3681 arg1Of concentration,a
R3034 T3683 T3682 arg1Of concentration,relative
R3035 T3683 T3684 arg1Of concentration,of
R3036 T3685 T3684 arg2Of 5,of
R3037 T3688 T3686 arg1Of CFU/ml,×
R3038 T3688 T3687 arg1Of CFU/ml,107
R3039 T3688 T3689 arg1Of CFU/ml,(
R3040 T3691 T3689 arg2Of 2b,(
R3041 T3691 T3690 arg1Of 2b,figure
R3042 T3692 T3689 arg3Of ),(
R3043 T3695 T3693 arg1Of activation,The
R3044 T3695 T3694 arg1Of activation,time-dependent
R3045 T3695 T3696 arg1Of activation,of
R3046 T3695 T3698 arg1Of activation,by
R3047 T3695 T3702 arg1Of activation,was
R3048 T3695 T3703 arg2Of activation,assessed
R3049 T3695 T3714 arg1Of activation,showed
R3050 T3697 T3696 arg2Of NF-κB,of
R3051 T3701 T3698 arg2Of coli,by
R3052 T3701 T3699 arg1Of coli,HK
R3053 T3701 T3700 arg1Of coli,E.
R3054 T3703 T3702 arg2Of assessed,was
R3055 T3703 T3704 arg1Of assessed,further
R3056 T3703 T3713 arg1Of assessed,and
R3057 T3705 T3703 arg3Of using,assessed
R3058 T3708 T3705 arg2Of concentration,using
R3059 T3708 T3706 arg1Of concentration,the
R3060 T3708 T3707 arg1Of concentration,optimal
R3061 T3708 T3709 arg2Of concentration,obtained
R3062 T3709 T3710 arg1Of obtained,from
R3063 T3712 T3710 arg2Of 2b,from
R3064 T3712 T3711 arg1Of 2b,figure
R3065 T3714 T3713 arg2Of showed,and
R3066 T3718 T3716 arg1Of activity,the
R3067 T3718 T3717 arg1Of activity,NF-κB
R3068 T3718 T3719 arg1Of activity,increased
R3069 T3719 T3714 arg2Of increased,showed
R3070 T3719 T3715 arg1Of increased,that
R3071 T3719 T3720 arg1Of increased,after
R3072 T3722 T3720 arg2Of h,after
R3073 T3722 T3721 arg1Of h,3
R3074 T3722 T3723 arg1Of h,of
R3075 T3724 T3723 arg2Of exposure,of
R3076 T3724 T3725 arg1Of exposure,(
R3077 T3727 T3725 arg2Of 2c,(
R3078 T3727 T3726 arg1Of 2c,figure
R3079 T3728 T3725 arg3Of ),(
R3080 T3733 T3731 arg2Of Ca2+,increased
R3081 T3733 T3732 arg1Of Ca2+,intracellular
R3082 T3733 T3734 arg1Of Ca2+,reversed
R3083 T3733 T3745 arg1Of Ca2+,reduced
R3084 T3734 T3744 arg1Of reversed,and
R3085 T3739 T3734 arg2Of inhibition,reversed
R3086 T3739 T3735 arg1Of inhibition,the
R3087 T3739 T3736 arg1Of inhibition,PMA
R3088 T3739 T3737 arg1Of inhibition,dependent
R3089 T3739 T3738 arg1Of inhibition,NF-κB
R3090 T3739 T3740 arg1Of inhibition,(
R3091 T3742 T3740 arg2Of 2d,(
R3092 T3742 T3741 arg1Of 2d,figure
R3093 T3743 T3740 arg3Of ),(
R3094 T3744 T3729 arg1Of and,Furthermore
R3095 T3744 T3730 arg1Of and,","
R3096 T3745 T3744 arg2Of reduced,and
R3097 T3752 T3745 arg2Of activation,reduced
R3098 T3752 T3746 arg1Of activation,the
R3099 T3752 T3747 arg1Of activation,HK
R3100 T3752 T3748 arg1Of activation,E.
R3101 T3752 T3749 arg1Of activation,coli
R3102 T3752 T3750 arg1Of activation,-dependent
R3103 T3752 T3751 arg1Of activation,NF-κB
R3104 T3752 T3753 arg1Of activation,(
R3105 T3755 T3753 arg2Of 2e,(
R3106 T3755 T3754 arg1Of 2e,figure
R3107 T3756 T3753 arg3Of ),(
R3400 T4162 T4163 arg1Of Induction,of
R3401 T4165 T4163 arg2Of responses,of
R3402 T4165 T4164 arg1Of responses,inflammatory
R3403 T4167 T4166 arg1Of ability,The
R3404 T4167 T4168 arg1Of ability,of
R3405 T4167 T4173 arg1Of ability,coli
R3406 T4167 T4174 modOf ability,to
R3407 T4167 T4182 arg1Of ability,was
R3408 T4167 T4183 arg2Of ability,evaluated
R3409 T4169 T4170 arg1Of PMA,and
R3410 T4170 T4168 arg2Of and,of
R3411 T4171 T4170 arg2Of HK,and
R3412 T4173 T4172 arg1Of coli,E.
R3413 T4175 T4174 arg1Of induce,to
R3414 T4178 T4175 arg2Of response,induce
R3415 T4178 T4176 arg1Of response,an
R3416 T4178 T4177 arg1Of response,inflammatory
R3417 T4178 T4179 arg1Of response,in
R3418 T4181 T4179 arg2Of T-cells,in
R3419 T4181 T4180 arg1Of T-cells,Jurkat
R3420 T4183 T4182 arg2Of evaluated,was
R3421 T4183 T4184 modOf evaluated,using
R3422 T4188 T4184 arg2Of assay,using
R3423 T4188 T4185 arg1Of assay,a
R3424 T4188 T4186 arg1Of assay,multiplex
R3425 T4188 T4187 arg1Of assay,cytokine
R3426 T4188 T4189 arg1Of assay,following
R3427 T4192 T4189 arg2Of stimulation,following
R3428 T4192 T4190 arg1Of stimulation,24
R3429 T4192 T4191 arg1Of stimulation,h
R3430 T4195 T4193 arg1Of profile,The
R3431 T4195 T4194 arg1Of profile,cytokine
R3432 T4195 T4196 arg1Of profile,revealed
R3433 T4199 T4196 arg2Of induction,revealed
R3434 T4199 T4197 arg1Of induction,an
R3435 T4199 T4198 arg2Of induction,enhanced
R3436 T4199 T4200 arg1Of induction,of
R3437 T4203 T4201 arg1Of cytokines,the
R3438 T4203 T4202 arg1Of cytokines,pro-inflammatory
R3439 T4204 T4205 arg1Of IL-2,","
R3440 T4205 T4203 arg1Of ",",cytokines
R3441 T4205 T4207 arg1Of ",",","
R3442 T4206 T4205 arg2Of IL-6,","
R3443 T4207 T4209 arg1Of ",",and
R3444 T4208 T4207 arg2Of TNF,","
R3445 T4209 T4200 arg2Of and,of
R3446 T4212 T4209 arg2Of CXCL8,and
R3447 T4212 T4210 arg1Of CXCL8,the
R3448 T4212 T4211 arg1Of CXCL8,chemokine
R3449 T4214 T4213 arg1Of levels,The
R3450 T4214 T4215 arg1Of levels,of
R3451 T4214 T4220 arg1Of levels,were
R3452 T4214 T4221 arg1Of levels,unaffected
R3453 T4214 T4225 arg1Of levels,were
R3454 T4214 T4227 arg2Of levels,decreased
R3455 T4219 T4215 arg2Of IL-10,of
R3456 T4219 T4216 arg1Of IL-10,the
R3457 T4219 T4217 arg1Of IL-10,anti-inflammatory
R3458 T4219 T4218 arg1Of IL-10,cytokine
R3459 T4220 T4224 arg1Of were,but
R3460 T4221 T4220 arg2Of unaffected,were
R3461 T4221 T4222 arg1Of unaffected,by
R3462 T4223 T4222 arg2Of PMA,by
R3463 T4227 T4224 arg2Of decreased,but
R3464 T4227 T4225 arg2Of decreased,were
R3465 T4227 T4226 arg1Of decreased,significantly
R3466 T4227 T4228 arg1Of decreased,by
R3467 T4231 T4228 arg2Of coli,by
R3468 T4231 T4229 arg1Of coli,HK
R3469 T4231 T4230 arg1Of coli,E.
R3470 T4231 T4232 arg1Of coli,(
R3471 T4234 T4232 arg2Of 1,(
R3472 T4234 T4233 arg1Of 1,Table
R3473 T4235 T4232 arg3Of ),(
R3474 T4237 T4236 arg1Of results,These
R3475 T4237 T4238 arg1Of results,confirmed
R3476 T4240 T4241 arg1Of PMA,and
R3477 T4241 T4244 arg1Of and,coli
R3478 T4241 T4245 arg1Of and,induced
R3479 T4242 T4241 arg2Of HK,and
R3480 T4244 T4243 arg1Of coli,E.
R3481 T4245 T4238 arg2Of induced,confirmed
R3482 T4245 T4239 arg1Of induced,that
R3483 T4248 T4245 arg2Of response,induced
R3484 T4248 T4246 arg1Of response,an
R3485 T4248 T4247 arg1Of response,inflammatory
R3486 T4248 T4249 arg1Of response,in
R3487 T4252 T4249 arg2Of T-cells,in
R3488 T4252 T4250 arg1Of T-cells,the
R3489 T4252 T4251 arg1Of T-cells,Jurkat
R3490 T4255 T4254 arg2Of interesting,is
R3491 T4257 T4253 arg1Of note,It
R3492 T4257 T4254 arg1Of note,is
R3493 T4257 T4255 arg1Of note,interesting
R3494 T4257 T4256 arg1Of note,to
R3495 T4259 T4260 arg1Of PMA,was
R3496 T4259 T4263 arg1Of PMA,effective
R3497 T4260 T4257 arg2Of was,note
R3498 T4260 T4258 arg1Of was,that
R3499 T4262 T4261 arg1Of more,120-fold
R3500 T4263 T4260 arg2Of effective,was
R3501 T4263 T4262 arg1Of effective,more
R3502 T4263 T4264 arg1Of effective,at
R3503 T4263 T4267 arg1Of effective,than
R3504 T4265 T4264 arg2Of inducing,at
R3505 T4266 T4265 arg2Of CXCL8,inducing
R3506 T4270 T4267 arg2Of coli,than
R3507 T4270 T4268 arg1Of coli,HK
R3508 T4270 T4269 arg1Of coli,E.
R3509 T4272 T4271 arg1Of induction,PMA-dependent
R3510 T4272 T4273 arg1Of induction,of
R3511 T4272 T4279 arg1Of induction,suggests
R3512 T4274 T4275 arg1Of AP-1,and
R3513 T4275 T4273 arg2Of and,of
R3514 T4276 T4275 arg2Of down-regulation,and
R3515 T4276 T4277 arg1Of down-regulation,of
R3516 T4278 T4277 arg2Of NF-κB,of
R3517 T4281 T4279 arg2Of involvement,suggests
R3518 T4281 T4280 arg1Of involvement,an
R3519 T4281 T4282 arg1Of involvement,of
R3520 T4281 T4284 arg1Of involvement,in
R3521 T4283 T4282 arg2Of AP-1,of
R3522 T4286 T4284 arg2Of regulation,in
R3523 T4286 T4285 arg1Of regulation,CXCL8
R3524 T4287 T4288 arg1Of Determination,of
R3525 T4287 T4299 arg1Of Determination,showed
R3526 T4291 T4288 arg2Of course,of
R3527 T4291 T4289 arg1Of course,the
R3528 T4291 T4290 arg1Of course,time
R3529 T4291 T4292 arg1Of course,of
R3530 T4294 T4292 arg2Of induction,of
R3531 T4294 T4293 arg1Of induction,cytokine
R3532 T4294 T4295 arg1Of induction,in
R3533 T4296 T4295 arg2Of response,in
R3534 T4296 T4297 arg1Of response,to
R3535 T4298 T4297 arg2Of PMA,to
R3536 T4301 T4302 arg1Of CXCL8,was
R3537 T4301 T4304 arg2Of CXCL8,released
R3538 T4304 T4299 arg2Of released,showed
R3539 T4304 T4300 arg1Of released,that
R3540 T4304 T4302 arg2Of released,was
R3541 T4304 T4303 arg1Of released,already
R3542 T4304 T4305 arg1Of released,between
R3543 T4304 T4308 arg1Of released,","
R3544 T4304 T4309 arg1Of released,while
R3545 T4307 T4305 arg2Of h,between
R3546 T4307 T4306 arg1Of h,2-6
R3547 T4310 T4311 arg1Of TNF,and
R3548 T4311 T4313 arg1Of and,were
R3549 T4311 T4314 arg2Of and,released
R3550 T4312 T4311 arg2Of IL-6,and
R3551 T4314 T4309 arg2Of released,while
R3552 T4314 T4313 arg2Of released,were
R3553 T4314 T4315 arg1Of released,between
R3554 T4317 T4315 arg2Of h,between
R3555 T4317 T4316 arg1Of h,6-24
R3556 T4317 T4318 arg1Of h,(
R3557 T4319 T4318 arg2Of figure,(
R3558 T4319 T4320 arg1Of figure,3
R3559 T4321 T4318 arg3Of ),(
R3560 T4323 T4322 arg1Of results,These
R3561 T4323 T4324 arg1Of results,indicated
R3562 T4327 T4326 arg1Of cytokines,the
R3563 T4327 T4328 arg1Of cytokines,were
R3564 T4327 T4330 arg2Of cytokines,regulated
R3565 T4330 T4325 arg1Of regulated,that
R3566 T4330 T4328 arg2Of regulated,were
R3567 T4330 T4329 arg1Of regulated,differentially
R3568 T4330 T4331 arg1Of regulated,and
R3569 T4331 T4324 arg2Of and,indicated
R3570 T4332 T4331 arg2Of that,and
R3571 T4334 T4333 arg1Of release,the
R3572 T4334 T4335 arg1Of release,was
R3573 T4334 T4337 arg2Of release,associated
R3574 T4337 T4332 arg2Of associated,that
R3575 T4337 T4335 arg2Of associated,was
R3576 T4337 T4336 arg1Of associated,not
R3577 T4337 T4338 arg1Of associated,with
R3578 T4342 T4338 arg2Of induction,with
R3579 T4342 T4339 arg1Of induction,the
R3580 T4342 T4340 arg1Of induction,early
R3581 T4342 T4341 arg1Of induction,transient
R3582 T4342 T4343 arg1Of induction,of
R3583 T4344 T4343 arg2Of NF-κB,of
R3584 T4347 T4345 arg1Of induction,The
R3585 T4347 T4346 arg1Of induction,temporal
R3586 T4347 T4348 arg1Of induction,of
R3587 T4347 T4350 arg1Of induction,correlated
R3588 T4347 T4356 arg1Of induction,preceded
R3589 T4349 T4348 arg2Of AP-1,of
R3590 T4350 T4351 arg1Of correlated,to
R3591 T4350 T4355 arg1Of correlated,and
R3592 T4354 T4351 arg2Of levels,to
R3593 T4354 T4352 arg1Of levels,the
R3594 T4354 T4353 arg1Of levels,CXCL8
R3595 T4356 T4355 arg2Of preceded,and
R3596 T4358 T4359 arg1Of TNF,and
R3597 T4360 T4359 arg2Of IL-6,and
R3598 T4361 T4356 arg2Of release,preceded
R3599 T4361 T4357 arg1Of release,the
R3600 T4361 T4358 arg1Of release,TNF
R3601 T4361 T4360 arg1Of release,IL-6
R3602 T4362 T4363 arg1Of This,suggests
R3603 T4365 T4363 arg2Of association,suggests
R3604 T4365 T4364 arg1Of association,an
R3605 T4365 T4366 arg1Of association,between
R3606 T4368 T4367 arg1Of release,CXCL8
R3607 T4368 T4369 arg1Of release,and
R3608 T4369 T4366 arg2Of and,between
R3609 T4371 T4369 arg2Of signalling,and
R3610 T4371 T4370 arg1Of signalling,AP-1
R4194 T5146 T5145 arg1Of induction,Cooperative
R4195 T5146 T5147 arg1Of induction,of
R4196 T5146 T5149 arg1Of induction,by
R4197 T5148 T5147 arg2Of cytokines,of
R4198 T5150 T5151 arg1Of AP-1,and
R4199 T5151 T5149 arg2Of and,by
R4200 T5152 T5151 arg2Of NF-κB,and
R4201 T5155 T5153 arg1Of characterize,To
R4202 T5155 T5154 arg1Of characterize,further
R4203 T5157 T5155 arg2Of involvement,characterize
R4204 T5157 T5156 arg1Of involvement,the
R4205 T5157 T5158 arg1Of involvement,of
R4206 T5157 T5160 arg1Of involvement,in
R4207 T5159 T5158 arg2Of NF-κB,of
R4208 T5162 T5160 arg2Of regulation,in
R4209 T5162 T5161 arg1Of regulation,cytokine
R4210 T5164 T5155 arg1Of we,characterize
R4211 T5164 T5165 arg1Of we,treated
R4212 T5165 T5153 modOf treated,To
R4213 T5165 T5163 arg1Of treated,","
R4214 T5165 T5167 arg1Of treated,with
R4215 T5166 T5165 arg2Of cells,treated
R4216 T5171 T5167 arg2Of inhibitor,with
R4217 T5171 T5168 arg1Of inhibitor,an
R4218 T5171 T5169 arg1Of inhibitor,NF-κB
R4219 T5171 T5170 arg1Of inhibitor,activation
R4220 T5171 T5172 arg1Of inhibitor,(
R4221 T5173 T5172 arg2Of NAI,(
R4222 T5174 T5172 arg3Of ),(
R4223 T5176 T5175 arg1Of results,The
R4224 T5176 T5177 arg1Of results,showed
R4225 T5179 T5181 arg1Of NAI,down-regulated
R4226 T5179 T5191 arg1Of NAI,did
R4227 T5179 T5193 arg1Of NAI,alter
R4228 T5181 T5190 arg1Of down-regulated,and
R4229 T5183 T5181 arg2Of activation,down-regulated
R4230 T5183 T5182 arg1Of activation,NF-κB
R4231 T5183 T5184 arg1Of activation,(
R4232 T5186 T5187 arg1Of 4a,and
R4233 T5187 T5184 arg2Of and,(
R4234 T5187 T5185 arg1Of and,figures
R4235 T5188 T5187 arg2Of 4b,and
R4236 T5189 T5184 arg3Of ),(
R4237 T5190 T5177 arg2Of and,showed
R4238 T5190 T5178 arg1Of and,that
R4239 T5190 T5180 arg1Of and,selectively
R4240 T5193 T5190 arg2Of alter,and
R4241 T5193 T5191 arg2Of alter,did
R4242 T5193 T5192 arg1Of alter,not
R4243 T5195 T5193 arg2Of activity,alter
R4244 T5195 T5194 arg1Of activity,AP-1
R4245 T5195 T5196 arg1Of activity,(
R4246 T5198 T5199 arg1Of 4c,and
R4247 T5199 T5196 arg2Of and,(
R4248 T5199 T5197 arg1Of and,figures
R4249 T5200 T5199 arg2Of 4d,and
R4250 T5201 T5196 arg3Of ),(
R4251 T5202 T5203 arg1Of Exposure,of
R4252 T5202 T5206 arg1Of Exposure,to
R4253 T5202 T5208 arg1Of Exposure,resulted
R4254 T5205 T5203 arg2Of T-cells,of
R4255 T5205 T5204 arg1Of T-cells,Jurkat
R4256 T5207 T5206 arg2Of NAI,to
R4257 T5208 T5209 arg1Of resulted,in
R4258 T5208 T5218 arg1Of resulted,","
R4259 T5208 T5219 arg1Of resulted,while
R4260 T5212 T5209 arg2Of reduction,in
R4261 T5212 T5210 arg1Of reduction,a
R4262 T5212 T5211 arg1Of reduction,modest
R4263 T5212 T5213 arg1Of reduction,of
R4264 T5212 T5215 arg1Of reduction,following
R4265 T5214 T5213 arg2Of CXCL8,of
R4266 T5217 T5215 arg2Of exposure,following
R4267 T5217 T5216 arg1Of exposure,PMA
R4268 T5220 T5221 arg1Of it,did
R4269 T5220 T5223 arg1Of it,alter
R4270 T5223 T5219 arg2Of alter,while
R4271 T5223 T5221 arg2Of alter,did
R4272 T5223 T5222 arg1Of alter,not
R4273 T5226 T5223 arg2Of release,alter
R4274 T5226 T5224 arg1Of release,the
R4275 T5226 T5225 arg1Of release,CXCL8
R4276 T5226 T5227 arg1Of release,following
R4277 T5231 T5227 arg2Of exposure,following
R4278 T5231 T5228 arg1Of exposure,HK
R4279 T5231 T5229 arg1Of exposure,E.
R4280 T5231 T5230 arg1Of exposure,coli
R4281 T5231 T5232 arg1Of exposure,(
R4282 T5234 T5232 arg2Of 5a,(
R4283 T5234 T5233 arg1Of 5a,figure
R4284 T5235 T5232 arg3Of ),(
R4285 T5236 T5237 arg1Of NAI,did
R4286 T5236 T5239 arg1Of NAI,affect
R4287 T5239 T5237 arg2Of affect,did
R4288 T5239 T5238 arg1Of affect,not
R4289 T5239 T5246 modOf affect,indicating
R4290 T5241 T5239 arg2Of expression,affect
R4291 T5241 T5240 arg1Of expression,TNF
R4292 T5241 T5242 arg1Of expression,(
R4293 T5244 T5242 arg2Of 5b,(
R4294 T5244 T5243 arg1Of 5b,figure
R4295 T5245 T5242 arg3Of ),(
R4296 T5248 T5249 arg1Of NF-κB,is
R4297 T5249 T5246 arg2Of is,indicating
R4298 T5249 T5247 arg1Of is,that
R4299 T5249 T5250 arg1Of is,not
R4300 T5253 T5249 arg2Of regulator,is
R4301 T5253 T5251 arg1Of regulator,the
R4302 T5253 T5252 arg1Of regulator,main
R4303 T5253 T5254 arg1Of regulator,of
R4304 T5253 T5258 arg1Of regulator,following
R4305 T5255 T5256 arg1Of CXCL8,or
R4306 T5256 T5254 arg2Of or,of
R4307 T5257 T5256 arg2Of TNF,or
R4308 T5260 T5261 arg1Of PMA,or
R4309 T5261 T5258 arg2Of or,following
R4310 T5261 T5259 arg1Of or,either
R4311 T5261 T5266 arg1Of or,in
R4312 T5265 T5261 arg2Of exposure,or
R4313 T5265 T5262 arg1Of exposure,HK
R4314 T5265 T5263 arg1Of exposure,E.
R4315 T5265 T5264 arg1Of exposure,coli
R4316 T5268 T5266 arg2Of T-cells,in
R4317 T5268 T5267 arg1Of T-cells,Jurkat
R4318 T5270 T5269 arg2Of contrast,In
R4319 T5272 T5273 arg1Of NAI,resulted
R4320 T5273 T5269 arg1Of resulted,In
R4321 T5273 T5271 arg1Of resulted,","
R4322 T5273 T5274 arg1Of resulted,in
R4323 T5273 T5297 arg1Of resulted,","
R4324 T5273 T5298 modOf resulted,suggesting
R4325 T5277 T5274 arg2Of inhibition,in
R4326 T5277 T5275 arg1Of inhibition,a
R4327 T5277 T5276 arg1Of inhibition,complete
R4328 T5277 T5278 arg1Of inhibition,of
R4329 T5277 T5280 arg1Of inhibition,following
R4330 T5279 T5278 arg2Of IL-6,of
R4331 T5282 T5281 arg1Of exposure,PMA
R4332 T5282 T5283 arg1Of exposure,and
R4333 T5283 T5280 arg2Of and,following
R4334 T5285 T5286 arg1Of 45,%
R4335 T5287 T5283 arg2Of inhibition,and
R4336 T5287 T5284 arg1Of inhibition,a
R4337 T5287 T5285 arg1Of inhibition,45
R4338 T5287 T5288 arg1Of inhibition,following
R4339 T5292 T5288 arg2Of exposure,following
R4340 T5292 T5289 arg1Of exposure,HK
R4341 T5292 T5290 arg1Of exposure,E.
R4342 T5292 T5291 arg1Of exposure,coli
R4343 T5292 T5293 arg1Of exposure,(
R4344 T5295 T5293 arg2Of 5c,(
R4345 T5295 T5294 arg1Of 5c,figure
R4346 T5296 T5293 arg3Of ),(
R4347 T5300 T5298 arg2Of involvement,suggesting
R4348 T5300 T5299 arg1Of involvement,an
R4349 T5300 T5301 arg1Of involvement,of
R4350 T5300 T5303 arg1Of involvement,in
R4351 T5302 T5301 arg2Of NF-κB,of
R4352 T5305 T5303 arg2Of regulation,in
R4353 T5305 T5304 arg1Of regulation,IL-6
R4354 T5306 T5307 arg1Of Ca2+,was
R4355 T5306 T5308 arg2Of Ca2+,observed
R4356 T5306 T5310 arg1Of Ca2+,increase
R4357 T5306 T5318 arg1Of Ca2+,reduce
R4358 T5308 T5307 arg2Of observed,was
R4359 T5308 T5325 arg1Of observed,;
R4360 T5310 T5317 arg1Of increase,and
R4361 T5312 T5310 arg2Of activity,increase
R4362 T5312 T5311 arg1Of activity,AP-1
R4363 T5312 T5313 arg1Of activity,(
R4364 T5315 T5313 arg2Of 1c,(
R4365 T5315 T5314 arg1Of 1c,figure
R4366 T5316 T5313 arg3Of ),(
R4367 T5317 T5308 arg3Of and,observed
R4368 T5317 T5309 arg1Of and,to
R4369 T5318 T5317 arg2Of reduce,and
R4370 T5320 T5318 arg2Of activity,reduce
R4371 T5320 T5319 arg1Of activity,NF-κB
R4372 T5320 T5321 arg1Of activity,(
R4373 T5323 T5321 arg2Of 2e,(
R4374 T5323 T5322 arg1Of 2e,figure
R4375 T5324 T5321 arg3Of ),(
R4376 T5328 T5329 arg1Of we,exposed
R4377 T5328 T5339 arg1Of we,determine
R4378 T5329 T5325 arg2Of exposed,;
R4379 T5329 T5326 arg1Of exposed,therefore
R4380 T5329 T5327 arg1Of exposed,","
R4381 T5329 T5331 arg1Of exposed,to
R4382 T5329 T5335 arg1Of exposed,together
R4383 T5329 T5338 modOf exposed,to
R4384 T5330 T5329 arg2Of T-cells,exposed
R4385 T5334 T5331 arg2Of inhibitor,to
R4386 T5334 T5332 arg1Of inhibitor,a
R4387 T5334 T5333 arg1Of inhibitor,PKC
R4388 T5335 T5336 arg1Of together,with
R4389 T5337 T5336 arg2Of PMA,with
R4390 T5339 T5338 arg1Of determine,to
R4391 T5341 T5339 arg2Of effect,determine
R4392 T5341 T5340 arg1Of effect,its
R4393 T5341 T5342 arg1Of effect,on
R4394 T5344 T5342 arg2Of expression,on
R4395 T5344 T5343 arg1Of expression,cytokine
R4396 T5345 T5346 arg1Of Inhibition,of
R4397 T5345 T5348 arg1Of Inhibition,reduced
R4398 T5347 T5346 arg2Of PKC,of
R4399 T5348 T5354 arg1Of reduced,to
R4400 T5348 T5357 arg1Of reduced,while
R4401 T5350 T5348 arg2Of release,reduced
R4402 T5350 T5349 arg1Of release,CXCL8
R4403 T5350 T5351 arg1Of release,from
R4404 T5353 T5351 arg2Of ng/ml,from
R4405 T5353 T5352 arg1Of ng/ml,7
R4406 T5356 T5354 arg2Of ng/ml,to
R4407 T5356 T5355 arg1Of ng/ml,3
R4408 T5358 T5359 arg1Of it,had
R4409 T5359 T5357 arg2Of had,while
R4410 T5359 T5363 arg1Of had,on
R4411 T5362 T5359 arg2Of effect,had
R4412 T5362 T5360 arg1Of effect,a
R4413 T5362 T5361 arg1Of effect,modest
R4414 T5364 T5365 arg1Of IL-6,and
R4415 T5365 T5363 arg2Of and,on
R4416 T5365 T5367 arg1Of and,(
R4417 T5366 T5365 arg2Of TNF,and
R4418 T5369 T5367 arg2Of 6a-c,(
R4419 T5369 T5368 arg1Of 6a-c,figure
R4420 T5370 T5367 arg3Of ),(
R4421 T5371 T5372 arg1Of This,prompted
R4422 T5373 T5372 arg2Of us,prompted
R4423 T5373 T5375 arg1Of us,test
R4424 T5375 T5372 arg3Of test,prompted
R4425 T5375 T5374 arg1Of test,to
R4426 T5377 T5375 arg2Of effect,test
R4427 T5377 T5376 arg1Of effect,the
R4428 T5377 T5378 arg1Of effect,of
R4429 T5377 T5381 arg1Of effect,on
R4430 T5380 T5378 arg2Of inhibition,of
R4431 T5380 T5379 arg1Of inhibition,JNK
R4432 T5384 T5381 arg2Of expression,on
R4433 T5384 T5382 arg1Of expression,PMA-induced
R4434 T5384 T5383 arg1Of expression,cytokine
R4435 T5385 T5386 arg1Of JNK,is
R4436 T5385 T5387 arg2Of JNK,involved
R4437 T5387 T5386 arg2Of involved,is
R4438 T5387 T5388 arg1Of involved,in
R4439 T5387 T5410 arg1Of involved,","
R4440 T5387 T5411 modOf involved,leading
R4441 T5390 T5388 arg2Of regulation,in
R4442 T5390 T5389 arg1Of regulation,the
R4443 T5390 T5391 arg1Of regulation,of
R4444 T5393 T5391 arg2Of multitude,of
R4445 T5393 T5392 arg1Of multitude,a
R4446 T5393 T5394 arg1Of multitude,of
R4447 T5397 T5395 arg1Of factors,different
R4448 T5397 T5396 arg1Of factors,transcription
R4449 T5397 T5398 arg1Of factors,","
R4450 T5397 T5399 arg1Of factors,including
R4451 T5397 T5406 arg1Of factors,","
R4452 T5401 T5402 arg1Of phosphorylation,and
R4453 T5402 T5399 arg2Of and,including
R4454 T5402 T5400 arg1Of and,the
R4455 T5402 T5404 arg1Of and,of
R4456 T5403 T5402 arg2Of activation,and
R4457 T5405 T5404 arg2Of c-Jun,of
R4458 T5406 T5394 arg2Of ",",of
R4459 T5407 T5408 arg1Of c-Fos,and
R4460 T5408 T5406 arg2Of and,","
R4461 T5409 T5408 arg2Of p53,and
R4462 T5411 T5412 arg1Of leading,to
R4463 T5414 T5412 arg2Of apoptosis,to
R4464 T5414 T5413 arg1Of apoptosis,cellular
R4465 T5414 T5415 arg1Of apoptosis,[
R4466 T5416 T5415 arg2Of 26,[
R4467 T5417 T5415 arg3Of ],[
R4468 T5418 T5419 arg1Of Inhibition,of
R4469 T5418 T5423 arg1Of Inhibition,resulted
R4470 T5422 T5419 arg2Of pathways,of
R4471 T5422 T5420 arg1Of pathways,the
R4472 T5422 T5421 arg1Of pathways,JNK
R4473 T5423 T5424 arg1Of resulted,in
R4474 T5423 T5432 arg1Of resulted,","
R4475 T5426 T5424 arg2Of down-regulation,in
R4476 T5426 T5425 arg1Of down-regulation,a
R4477 T5426 T5427 arg1Of down-regulation,of
R4478 T5429 T5430 arg1Of CXCL8,and
R4479 T5430 T5427 arg2Of and,of
R4480 T5430 T5428 arg1Of and,both
R4481 T5431 T5430 arg2Of IL-6,and
R4482 T5433 T5423 arg2Of while,resulted
R4483 T5436 T5434 arg1Of effect,no
R4484 T5436 T5435 arg1Of effect,clear
R4485 T5436 T5437 arg1Of effect,was
R4486 T5436 T5438 arg2Of effect,observed
R4487 T5438 T5433 arg2Of observed,while
R4488 T5438 T5437 arg2Of observed,was
R4489 T5438 T5439 arg1Of observed,on
R4490 T5441 T5439 arg2Of expression,on
R4491 T5441 T5440 arg1Of expression,TNF
R4492 T5441 T5442 arg1Of expression,(
R4493 T5444 T5442 arg2Of 6a-c,(
R4494 T5444 T5443 arg1Of 6a-c,figure
R4495 T5445 T5442 arg3Of ),(
R4496 T5446 T5447 arg1Of Analysis,of
R4497 T5446 T5456 arg1Of Analysis,showed
R4498 T5449 T5447 arg2Of levels,of
R4499 T5449 T5448 arg1Of levels,mRNA
R4500 T5449 T5450 arg1Of levels,using
R4501 T5451 T5450 arg2Of RT-qPCR,using
R4502 T5451 T5452 arg1Of RT-qPCR,(
R4503 T5453 T5452 arg2Of table,(
R4504 T5453 T5454 arg1Of table,2
R4505 T5455 T5452 arg3Of ),(
R4506 T5458 T5459 arg1Of PMA,induced
R4507 T5459 T5456 arg2Of induced,showed
R4508 T5459 T5457 arg1Of induced,that
R4509 T5461 T5462 arg1Of il-6,and
R4510 T5463 T5462 arg2Of cxcl8,and
R4511 T5464 T5459 arg2Of mRNA,induced
R4512 T5464 T5460 arg1Of mRNA,both
R4513 T5464 T5461 arg1Of mRNA,il-6
R4514 T5464 T5463 arg1Of mRNA,cxcl8
R4515 T5464 T5465 arg1Of mRNA,(
R4516 T5466 T5467 arg1Of 5.1-fold,and
R4517 T5467 T5465 arg2Of and,(
R4518 T5467 T5470 arg1Of and,respectively
R4519 T5468 T5467 arg2Of 111.8,and
R4520 T5470 T5469 arg1Of respectively,fold
R4521 T5471 T5465 arg3Of ),(
R4522 T5472 T5473 arg1Of Addition,of
R4523 T5472 T5482 arg1Of Addition,reduced
R4524 T5477 T5474 arg1Of NAI,the
R4525 T5477 T5475 arg1Of NAI,NF-κB
R4526 T5477 T5476 arg1Of NAI,inhibitor
R4527 T5477 T5478 arg1Of NAI,and
R4528 T5478 T5473 arg2Of and,of
R4529 T5481 T5478 arg2Of inhibitor,and
R4530 T5481 T5479 arg1Of inhibitor,the
R4531 T5481 T5480 arg1Of inhibitor,JNK
R4532 T5485 T5482 arg2Of expression,reduced
R4533 T5485 T5483 arg1Of expression,the
R4534 T5485 T5484 arg1Of expression,il-6
R4535 T5485 T5486 arg1Of expression,below
R4536 T5488 T5486 arg2Of levels,below
R4537 T5488 T5487 arg1Of levels,basal
R4538 T5490 T5489 arg2Of contrast,In
R4539 T5495 T5493 arg1Of levels,the
R4540 T5495 T5494 arg1Of levels,cxcl8
R4541 T5495 T5496 arg1Of levels,were
R4542 T5495 T5497 arg2Of levels,suppressed
R4543 T5497 T5492 arg2Of suppressed,while
R4544 T5497 T5496 arg2Of suppressed,were
R4545 T5501 T5497 arg1Of treatments,suppressed
R4546 T5501 T5498 arg2Of treatments,by
R4547 T5501 T5499 arg1Of treatments,the
R4548 T5501 T5500 arg1Of treatments,same
R4549 T5503 T5502 arg1Of levels,the
R4550 T5503 T5504 arg1Of levels,remained
R4551 T5503 T5505 arg1Of levels,elevated
R4552 T5504 T5489 arg1Of remained,In
R4553 T5504 T5491 arg1Of remained,","
R4554 T5504 T5492 arg1Of remained,while
R4555 T5504 T5506 arg1Of remained,above
R4556 T5505 T5504 arg2Of elevated,remained
R4557 T5508 T5506 arg2Of level,above
R4558 T5508 T5507 arg1Of level,basal
R4965 T6148 T6147 arg1Of inhibition,NF-κB
R4966 T6148 T6150 arg1Of inhibition,to
R4967 T6150 T6149 arg1Of to,due
R4968 T6153 T6150 arg2Of degradation,to
R4969 T6153 T6151 arg1Of degradation,PKC-dependent
R4970 T6153 T6152 arg1Of degradation,Bcl10
R4971 T6156 T6154 arg1Of analysis,Western
R4972 T6156 T6155 arg1Of analysis,blot
R4973 T6156 T6157 arg1Of analysis,revealed
R4974 T6157 T6162 arg1Of revealed,after
R4975 T6157 T6179 arg1Of revealed,","
R4976 T6157 T6180 arg1Of revealed,while
R4977 T6159 T6157 arg2Of up-regulation,revealed
R4978 T6159 T6158 arg1Of up-regulation,an
R4979 T6159 T6160 arg1Of up-regulation,of
R4980 T6161 T6160 arg2Of phosphorylated-PKC,of
R4981 T6163 T6164 arg1Of 24,h
R4982 T6165 T6163 arg1Of treatment,24
R4983 T6165 T6166 arg1Of treatment,of
R4984 T6165 T6171 arg1Of treatment,or
R4985 T6168 T6166 arg2Of T-cells,of
R4986 T6168 T6167 arg1Of T-cells,Jurkat
R4987 T6168 T6169 arg1Of T-cells,with
R4988 T6170 T6169 arg2Of PMA,with
R4989 T6171 T6162 arg2Of or,after
R4990 T6174 T6171 arg2Of coli,or
R4991 T6174 T6172 arg1Of coli,HK
R4992 T6174 T6173 arg1Of coli,E.
R4993 T6174 T6175 arg1Of coli,(
R4994 T6177 T6175 arg2Of 7a,(
R4995 T6177 T6176 arg1Of 7a,figure
R4996 T6178 T6175 arg3Of ),(
R4997 T6182 T6181 arg1Of levels,IκBβ
R4998 T6182 T6183 arg1Of levels,remained
R4999 T6182 T6184 arg1Of levels,unaffected
R5000 T6183 T6180 arg2Of remained,while
R5001 T6184 T6183 arg2Of unaffected,remained
R5002 T6184 T6185 arg1Of unaffected,(
R5003 T6187 T6185 arg2Of 7b,(
R5004 T6187 T6186 arg1Of 7b,figure
R5005 T6188 T6185 arg3Of ),(
R5006 T6189 T6190 arg1Of Bcl10,is
R5007 T6193 T6190 arg2Of protein,is
R5008 T6193 T6191 arg1Of protein,a
R5009 T6193 T6192 arg1Of protein,signalling
R5010 T6193 T6194 arg1Of protein,that
R5011 T6193 T6195 arg1Of protein,acts
R5012 T6193 T6206 arg1Of protein,has
R5013 T6193 T6207 arg1Of protein,been
R5014 T6193 T6208 arg2Of protein,suggested
R5015 T6193 T6211 arg1Of protein,regulate
R5016 T6195 T6196 arg1Of acts,upstream
R5017 T6195 T6199 arg1Of acts,in
R5018 T6195 T6205 arg1Of acts,and
R5019 T6196 T6197 arg1Of upstream,of
R5020 T6198 T6197 arg2Of NF-κB,of
R5021 T6199 T6201 arg1Of in,with
R5022 T6200 T6199 arg2Of concert,in
R5023 T6202 T6203 arg1Of CARMA1,and
R5024 T6203 T6199 arg3Of and,in
R5025 T6204 T6203 arg2Of MALT1,and
R5026 T6208 T6205 arg2Of suggested,and
R5027 T6208 T6206 arg2Of suggested,has
R5028 T6208 T6207 arg2Of suggested,been
R5029 T6211 T6208 arg3Of regulate,suggested
R5030 T6211 T6209 arg1Of regulate,to
R5031 T6211 T6210 arg1Of regulate,directly
R5032 T6213 T6211 arg2Of activity,regulate
R5033 T6213 T6212 arg1Of activity,NF-κB
R5034 T6213 T6214 arg1Of activity,in
R5035 T6215 T6214 arg2Of T-cells,in
R5036 T6215 T6216 arg1Of T-cells,[
R5037 T6217 T6216 arg2Of 27,[
R5038 T6218 T6216 arg3Of ],[
R5039 T6222 T6221 arg1Of activation,Bcl10
R5040 T6222 T6223 arg1Of activation,was
R5041 T6222 T6224 arg2Of activation,evaluated
R5042 T6224 T6219 arg1Of evaluated,Therefore
R5043 T6224 T6220 arg1Of evaluated,","
R5044 T6224 T6223 arg2Of evaluated,was
R5045 T6224 T6225 arg1Of evaluated,in
R5046 T6224 T6232 arg1Of evaluated,after
R5047 T6227 T6228 arg1Of control,and
R5048 T6228 T6225 arg2Of and,in
R5049 T6228 T6226 arg1Of and,both
R5050 T6231 T6228 arg2Of cells,and
R5051 T6231 T6229 arg1Of cells,PMA
R5052 T6231 T6230 arg1Of cells,stimulated
R5053 T6234 T6233 arg1Of min,10
R5054 T6234 T6235 arg1Of min,","
R5055 T6235 T6238 arg1Of ",",","
R5056 T6237 T6235 arg2Of h,","
R5057 T6237 T6236 arg1Of h,1
R5058 T6238 T6242 arg1Of ",",and
R5059 T6240 T6238 arg2Of h,","
R5060 T6240 T6239 arg1Of h,6
R5061 T6242 T6232 arg2Of and,after
R5062 T6242 T6241 arg1Of and,","
R5063 T6244 T6242 arg2Of h,and
R5064 T6244 T6243 arg1Of h,24
R5065 T6244 T6245 arg1Of h,using
R5066 T6248 T6245 arg2Of analysis,using
R5067 T6248 T6246 arg1Of analysis,western
R5068 T6248 T6247 arg1Of analysis,blot
R5069 T6251 T6249 arg1Of levels,The
R5070 T6251 T6250 arg1Of levels,Bcl10
R5071 T6251 T6252 arg1Of levels,decreased
R5072 T6252 T6253 arg1Of decreased,following
R5073 T6252 T6257 arg1Of decreased,","
R5074 T6254 T6253 arg2Of treatment,following
R5075 T6254 T6255 arg1Of treatment,with
R5076 T6256 T6255 arg2Of PMA,with
R5077 T6258 T6252 arg2Of while,decreased
R5078 T6261 T6259 arg2Of cells,in
R5079 T6261 T6260 arg1Of cells,control
R5080 T6263 T6264 arg1Of Bcl10,returned
R5081 T6264 T6258 arg2Of returned,while
R5082 T6264 T6259 arg1Of returned,in
R5083 T6264 T6262 arg1Of returned,","
R5084 T6264 T6265 arg1Of returned,to
R5085 T6264 T6268 arg1Of returned,by
R5086 T6267 T6265 arg2Of levels,to
R5087 T6267 T6266 arg1Of levels,higher
R5088 T6270 T6268 arg2Of h,by
R5089 T6270 T6269 arg1Of h,24
R5090 T6270 T6271 arg1Of h,(
R5091 T6273 T6271 arg2Of 7c,(
R5092 T6273 T6272 arg1Of 7c,figure
R5093 T6274 T6271 arg3Of ),(
R5094 T6275 T6276 arg1Of This,suggests
R5095 T6278 T6279 arg1Of Bcl10,is
R5096 T6278 T6280 arg2Of Bcl10,involved
R5097 T6280 T6276 arg2Of involved,suggests
R5098 T6280 T6277 arg1Of involved,that
R5099 T6280 T6279 arg2Of involved,is
R5100 T6280 T6281 arg1Of involved,in
R5101 T6285 T6281 arg2Of inhibition,in
R5102 T6285 T6282 arg1Of inhibition,the
R5103 T6285 T6283 arg1Of inhibition,PMA
R5104 T6285 T6284 arg1Of inhibition,dependent
R5105 T6285 T6286 arg1Of inhibition,of
R5106 T6288 T6286 arg2Of activation,of
R5107 T6288 T6287 arg1Of activation,NF-κB
R12300 T15151 T15150 arg1Of activation,AP-1
R12301 T15151 T15152 arg1Of activation,following
R12302 T15154 T15152 arg2Of exposure,following
R12303 T15154 T15153 arg1Of exposure,long-term
R12304 T15154 T15155 arg1Of exposure,of
R12305 T15154 T15158 arg1Of exposure,to
R12306 T15157 T15155 arg2Of T-cells,of
R12307 T15157 T15156 arg1Of T-cells,Jurkat
R12308 T15159 T15158 arg2Of PMA,to
R12309 T15161 T15160 arg1Of T-cells,Jurkat
R12310 T15161 T15162 arg1Of T-cells,were
R12311 T15161 T15163 arg2Of T-cells,transfected
R12312 T15163 T15162 arg2Of transfected,were
R12313 T15163 T15164 arg1Of transfected,with
R12314 T15167 T15164 arg2Of plasmids,with
R12315 T15167 T15165 arg1Of plasmids,luciferase
R12316 T15167 T15166 arg1Of plasmids,reporter
R12317 T15167 T15168 arg1Of plasmids,containing
R12318 T15167 T15214 arg1Of plasmids,(
R12319 T15168 T15178 arg1Of containing,in
R12320 T15168 T15209 arg1Of containing,in
R12321 T15173 T15172 arg2Of A,(
R12322 T15174 T15172 arg3Of ),(
R12323 T15177 T15168 arg2Of activation,containing
R12324 T15177 T15169 arg1Of activation,the
R12325 T15177 T15170 arg1Of activation,AP-1
R12326 T15177 T15171 arg1Of activation,cis-elements.
R12327 T15177 T15172 arg1Of activation,(
R12328 T15177 T15175 arg1Of activation,Time-dependent
R12329 T15177 T15176 arg1Of activation,AP-1
R12330 T15178 T15208 arg1Of in,and
R12331 T15179 T15178 arg2Of response,in
R12332 T15179 T15180 arg1Of response,to
R12333 T15181 T15180 arg2Of PMA.,to
R12334 T15181 T15182 arg1Of PMA.,(
R12335 T15181 T15185 arg1Of PMA.,HK
R12336 T15181 T15190 arg2Of PMA.,activate
R12337 T15183 T15182 arg2Of B,(
R12338 T15184 T15182 arg3Of ),(
R12339 T15187 T15186 arg1Of coli,E.
R12340 T15187 T15188 arg1Of coli,does
R12341 T15187 T15190 arg1Of coli,activate
R12342 T15190 T15188 arg2Of activate,does
R12343 T15190 T15189 arg1Of activate,not
R12344 T15191 T15178 arg3Of AP-1.,in
R12345 T15191 T15199 modOf AP-1.,were
R12346 T15193 T15192 arg2Of C,(
R12347 T15194 T15192 arg3Of ),(
R12348 T15196 T15192 arg1Of activation,(
R12349 T15196 T15195 arg1Of activation,Dose-dependent
R12350 T15196 T15197 arg1Of activation,of
R12351 T15196 T15199 arg1Of activation,were
R12352 T15196 T15200 arg2Of activation,performed
R12353 T15198 T15197 arg2Of AP-1,of
R12354 T15200 T15199 arg2Of performed,were
R12355 T15201 T15200 arg3Of using,performed
R12356 T15202 T15201 arg2Of PMA,using
R12357 T15202 T15203 arg1Of PMA,alone
R12358 T15202 T15204 arg1Of PMA,(
R12359 T15206 T15204 arg2Of bars,(
R12360 T15206 T15205 arg1Of bars,grey
R12361 T15207 T15204 arg3Of ),(
R12362 T15209 T15208 arg2Of in,and
R12363 T15210 T15209 arg2Of combination,in
R12364 T15210 T15211 arg1Of combination,with
R12365 T15213 T15211 arg2Of ionophore,with
R12366 T15213 T15212 arg1Of ionophore,calcium
R12367 T15217 T15214 arg2Of μM,(
R12368 T15217 T15215 arg1Of μM,CaI
R12369 T15217 T15216 arg1Of μM,955
R12370 T15217 T15218 arg1Of μM,","
R12371 T15220 T15218 arg2Of bars,","
R12372 T15220 T15219 arg1Of bars,black
R12373 T15221 T15214 arg3Of ),(
R12374 T15223 T15222 arg2Of (,.
R12375 T15224 T15222 arg3Of D,.
R12376 T15227 T15222 arg1Of ent c,.
R12377 T15227 T15225 arg1Of ent c,) TCR-
R12378 T15227 T15226 arg1Of ent c,/- defici
R12379 T15227 T15228 arg1Of ent c,ells resp
R12380 T15227 T15236 arg1Of ent c,2 nM) by up-r
R12381 T15228 T15162 modOf ells resp,were
R12382 T15228 T15229 arg1Of ells resp,on
R12383 T15228 T15235 arg1Of ells resp,16
R12384 T15230 T15229 arg2Of ded,on
R12385 T15230 T15231 arg1Of ded,t
R12386 T15233 T15231 arg2Of MA,t
R12387 T15233 T15232 arg1Of MA,o P
R12388 T15234 T15231 arg3Of (,t
R12389 T15236 T15235 arg2Of 2 nM) by up-r,16
R12390 T15238 T15236 arg2Of ating AP,2 nM) by up-r
R12391 T15238 T15237 arg1Of ating AP,egul
R12392 T15240 T15239 arg1Of significance,Statistical
R12393 T15240 T15241 arg1Of significance,from
R12394 T15240 T15244 arg1Of significance,was
R12395 T15240 T15245 arg2Of significance,determined
R12396 T15243 T15241 arg2Of control,from
R12397 T15243 T15242 arg1Of control,the
R12398 T15245 T15244 arg2Of determined,was
R12399 T15246 T15245 arg3Of using,determined
R12400 T15247 T15248 arg2Of Student,'s
R12401 T15249 T15246 arg2Of t-test.,using
R12402 T15249 T15248 arg1Of t-test.,'s
R12403 T15249 T15250 arg1Of t-test.,(
R12404 T15251 T15250 arg2Of n,(
R12405 T15251 T15252 arg1Of n,=
R12406 T15251 T15253 arg1Of n,4
R12407 T15254 T15250 arg3Of ),(
R12408 T15255 T15256 arg1Of Controls,were
R12409 T15255 T15258 arg2Of Controls,set
R12410 T15258 T15256 arg2Of set,were
R12411 T15258 T15257 arg1Of set,arbitrarily
R12412 T15258 T15259 arg1Of set,to
R12413 T15260 T15259 arg2Of 1,to
R12536 T15426 T15425 arg1Of down-regulation,NF-κB
R12537 T15426 T15427 arg1Of down-regulation,by
R12538 T15426 T15431 arg1Of down-regulation,by
R12539 T15426 T15433 arg1Of down-regulation,killed
R12540 T15428 T15429 arg1Of PMA,and
R12541 T15429 T15427 arg2Of and,by
R12542 T15430 T15429 arg2Of up-regulation,and
R12543 T15432 T15431 arg2Of heat,by
R12544 T15433 T15437 arg1Of killed,following
R12545 T15436 T15433 arg2Of MG1655,killed
R12546 T15436 T15434 arg1Of MG1655,E.
R12547 T15436 T15435 arg1Of MG1655,coli
R12548 T15439 T15437 arg2Of stimulation,following
R12549 T15439 T15438 arg1Of stimulation,long-term
R12550 T15440 T15441 arg1Of Transfection,of
R12551 T15440 T15444 arg1Of Transfection,was
R12552 T15440 T15445 arg2Of Transfection,performed
R12553 T15443 T15441 arg2Of T-cells,of
R12554 T15443 T15442 arg1Of T-cells,Jurkat
R12555 T15445 T15444 arg2Of performed,was
R12556 T15446 T15445 arg3Of using,performed
R12557 T15449 T15446 arg2Of plasmids,using
R12558 T15449 T15447 arg1Of plasmids,luciferase
R12559 T15449 T15448 arg1Of plasmids,reporter
R12560 T15449 T15450 arg1Of plasmids,containing
R12561 T15454 T15453 arg2Of A,(
R12562 T15455 T15453 arg3Of ),(
R12563 T15457 T15450 arg2Of stimulation,containing
R12564 T15457 T15451 arg1Of stimulation,NF-κB
R12565 T15457 T15452 arg1Of stimulation,cis-elements.
R12566 T15457 T15453 arg1Of stimulation,(
R12567 T15457 T15456 arg1Of stimulation,Time-dependent
R12568 T15457 T15458 arg1Of stimulation,of
R12569 T15460 T15458 arg2Of T-cells,of
R12570 T15460 T15459 arg1Of T-cells,Jurkat
R12571 T15460 T15461 arg1Of T-cells,using
R12572 T15462 T15461 arg2Of PMA,using
R12573 T15464 T15463 arg1Of activation,NF-κB
R12574 T15464 T15465 arg1Of activation,was
R12575 T15464 T15466 arg2Of activation,evaluated
R12576 T15466 T15465 arg2Of evaluated,was
R12577 T15466 T15467 modOf evaluated,using
R12578 T15470 T15468 arg1Of coli,HK
R12579 T15470 T15469 arg1Of coli,E.
R12580 T15470 T15471 arg1Of coli,in
R12581 T15470 T15477 arg1Of coli,and
R12582 T15474 T15473 arg2Of B,(
R12583 T15475 T15473 arg3Of ),(
R12584 T15476 T15471 arg2Of dose-,in
R12585 T15476 T15472 arg1Of dose-,a
R12586 T15476 T15473 arg1Of dose-,(
R12587 T15477 T15467 arg2Of and,using
R12588 T15479 T15478 arg2Of C,(
R12589 T15480 T15478 arg3Of ),(
R12590 T15482 T15477 arg2Of manner,and
R12591 T15482 T15478 arg1Of manner,(
R12592 T15482 T15481 arg1Of manner,time-dependant
R12593 T15484 T15483 arg1Of ionophore,Calcium
R12594 T15484 T15485 arg1Of ionophore,increased
R12595 T15484 T15495 arg1Of ionophore,resulted
R12596 T15485 T15488 arg1Of increased,following
R12597 T15485 T15494 arg1Of increased,and
R12598 T15487 T15485 arg2Of activity,increased
R12599 T15487 T15486 arg1Of activity,NF-κB
R12600 T15490 T15488 arg2Of exposure,following
R12601 T15490 T15489 arg1Of exposure,PMA
R12602 T15490 T15491 arg1Of exposure,(
R12603 T15492 T15491 arg2Of E,(
R12604 T15493 T15491 arg3Of ),(
R12605 T15495 T15494 arg2Of resulted,and
R12606 T15495 T15496 arg1Of resulted,in
R12607 T15495 T15500 arg1Of resulted,in
R12608 T15499 T15496 arg2Of regulation,in
R12609 T15499 T15497 arg1Of regulation,a
R12610 T15499 T15498 arg1Of regulation,negative
R12611 T15501 T15500 arg2Of response,in
R12612 T15501 T15502 arg1Of response,to
R12613 T15503 T15502 arg2Of HK,to
R12614 T15506 T15500 arg3Of stimulation,in
R12615 T15506 T15504 arg1Of stimulation,E.
R12616 T15506 T15505 arg1Of stimulation,coli
R12617 T15506 T15507 arg1Of stimulation,(
R12618 T15508 T15507 arg2Of D,(
R12619 T15509 T15507 arg3Of ),(
R12620 T15511 T15510 arg1Of significance,Statistical
R12621 T15511 T15512 arg1Of significance,from
R12622 T15511 T15515 arg1Of significance,was
R12623 T15511 T15516 arg2Of significance,determined
R12624 T15514 T15512 arg2Of control,from
R12625 T15514 T15513 arg1Of control,the
R12626 T15516 T15515 arg2Of determined,was
R12627 T15517 T15516 arg3Of using,determined
R12628 T15518 T15519 arg2Of Student,'s
R12629 T15520 T15517 arg2Of t-test.,using
R12630 T15520 T15519 arg1Of t-test.,'s
R12631 T15520 T15521 arg1Of t-test.,(
R12632 T15522 T15521 arg2Of n,(
R12633 T15522 T15523 arg1Of n,=
R12634 T15522 T15524 arg1Of n,4
R12635 T15525 T15521 arg3Of ),(
R12636 T15526 T15527 arg1Of Controls,were
R12637 T15526 T15529 arg2Of Controls,set
R12638 T15529 T15527 arg2Of set,were
R12639 T15529 T15528 arg1Of set,arbitrarily
R12640 T15529 T15530 arg1Of set,to
R12641 T15531 T15530 arg2Of 1,to
R12762 T15704 T15705 arg1Of CXCL8,","
R12763 T15705 T15707 arg1Of ",",and
R12764 T15706 T15705 arg2Of IL-6,","
R12765 T15708 T15707 arg2Of TNF,and
R12766 T15709 T15704 arg1Of expression,CXCL8
R12767 T15709 T15706 arg1Of expression,IL-6
R12768 T15709 T15708 arg1Of expression,TNF
R12769 T15709 T15710 arg1Of expression,following
R12770 T15712 T15710 arg2Of stimulation,following
R12771 T15712 T15711 arg1Of stimulation,long-term
R12772 T15712 T15713 arg1Of stimulation,with
R12773 T15714 T15713 arg2Of PMA,with
R12774 T15716 T15715 arg1Of T-cells,Jurkat
R12775 T15716 T15717 arg1Of T-cells,were
R12776 T15716 T15719 arg2Of T-cells,treated
R12777 T15716 T15727 arg2Of T-cells,stimulated
R12778 T15716 T15735 arg2Of T-cells,incubated
R12779 T15719 T15720 arg1Of treated,with
R12780 T15719 T15726 arg1Of treated,or
R12781 T15721 T15720 arg2Of media,with
R12782 T15721 T15722 arg1Of media,(
R12783 T15724 T15722 arg2Of bars,(
R12784 T15724 T15723 arg1Of bars,white
R12785 T15725 T15722 arg3Of ),(
R12786 T15726 T15734 arg1Of or,and
R12787 T15727 T15726 arg2Of stimulated,or
R12788 T15727 T15728 arg1Of stimulated,with
R12789 T15729 T15728 arg2Of PMA,with
R12790 T15729 T15730 arg1Of PMA,(
R12791 T15732 T15730 arg2Of bars,(
R12792 T15732 T15731 arg1Of bars,black
R12793 T15733 T15730 arg3Of ),(
R12794 T15734 T15717 arg2Of and,were
R12795 T15734 T15718 arg1Of and,either
R12796 T15735 T15734 arg2Of incubated,and
R12797 T15735 T15736 arg1Of incubated,for
R12798 T15738 T15737 arg1Of h,1
R12799 T15738 T15739 arg1Of h,","
R12800 T15739 T15742 arg1Of ",",","
R12801 T15741 T15739 arg2Of h,","
R12802 T15741 T15740 arg1Of h,2
R12803 T15742 T15745 arg1Of ",",and
R12804 T15744 T15742 arg2Of h,","
R12805 T15744 T15743 arg1Of h,6
R12806 T15745 T15736 arg2Of and,for
R12807 T15747 T15745 arg2Of h,and
R12808 T15747 T15746 arg1Of h,24
R12809 T15749 T15748 arg1Of media,Aged
R12810 T15749 T15750 arg1Of media,was
R12811 T15749 T15751 arg2Of media,added
R12812 T15751 T15750 arg2Of added,was
R12813 T15751 T15752 arg1Of added,following
R12814 T15751 T15761 arg1Of added,(
R12815 T15755 T15752 arg2Of step,following
R12816 T15755 T15753 arg1Of step,each
R12817 T15755 T15754 arg1Of step,centrifugation
R12818 T15755 T15756 arg1Of step,representative
R12819 T15756 T15757 arg1Of representative,to
R12820 T15760 T15757 arg2Of time,to
R12821 T15760 T15758 arg1Of time,the
R12822 T15760 T15759 arg1Of time,stimulation
R12823 T15762 T15761 arg2Of see,(
R12824 T15763 T15764 arg1Of Materials,and
R12825 T15764 T15762 arg2Of and,see
R12826 T15765 T15764 arg2Of methods,and
R12827 T15766 T15761 arg3Of ),(
R12828 T15768 T15767 arg1Of levels,Cytokine
R12829 T15768 T15769 arg1Of levels,(
R12830 T15770 T15769 arg2Of A,(
R12831 T15771 T15769 arg3Of ),(
R12832 T15772 T15768 arg1Of CXCL8,levels
R12833 T15772 T15773 arg1Of CXCL8,","
R12834 T15773 T15778 arg1Of ",",and
R12835 T15775 T15774 arg2Of B,(
R12836 T15776 T15774 arg3Of ),(
R12837 T15777 T15773 arg2Of IL-6,","
R12838 T15777 T15774 arg1Of IL-6,(
R12839 T15778 T15783 arg1Of and,were
R12840 T15778 T15784 arg2Of and,detected
R12841 T15780 T15779 arg2Of C,(
R12842 T15781 T15779 arg3Of ),(
R12843 T15782 T15778 arg2Of TNF,and
R12844 T15782 T15779 arg1Of TNF,(
R12845 T15784 T15783 arg2Of detected,were
R12846 T15786 T15784 arg1Of ELISA,detected
R12847 T15786 T15785 arg2Of ELISA,by
R12848 T15788 T15787 arg1Of significance,Statistical
R12849 T15788 T15789 arg1Of significance,from
R12850 T15788 T15792 arg1Of significance,was
R12851 T15788 T15793 arg2Of significance,determined
R12852 T15791 T15789 arg2Of control,from
R12853 T15791 T15790 arg1Of control,the
R12854 T15793 T15792 arg2Of determined,was
R12855 T15794 T15793 arg3Of using,determined
R12856 T15795 T15796 arg2Of Student,'s
R12857 T15797 T15794 arg2Of t-test.,using
R12858 T15797 T15796 arg1Of t-test.,'s
R12859 T15797 T15798 arg1Of t-test.,(
R12860 T15799 T15798 arg2Of n,(
R12861 T15799 T15800 arg1Of n,=
R12862 T15799 T15801 arg1Of n,3
R12863 T15802 T15798 arg3Of ),(
R13004 T15991 T15992 arg1Of Inhibition,of
R13005 T15991 T15995 arg1Of Inhibition,by
R13006 T15994 T15992 arg2Of activity,of
R13007 T15994 T15993 arg1Of activity,NF-κB
R13008 T15996 T15995 arg2Of NAI,by
R13009 T15998 T15997 arg1Of T-cells,Jurkat
R13010 T15998 T15999 arg1Of T-cells,were
R13011 T15998 T16000 arg2Of T-cells,transfected
R13012 T16000 T15999 arg2Of transfected,were
R13013 T16000 T16001 arg1Of transfected,with
R13014 T16004 T16001 arg2Of plasmids,with
R13015 T16004 T16002 arg1Of plasmids,luciferase
R13016 T16004 T16003 arg1Of plasmids,reporter
R13017 T16004 T16005 arg1Of plasmids,containing
R13018 T16007 T16008 arg1Of NF-κB,or
R13019 T16009 T16008 arg2Of AP-1,or
R13020 T16011 T16005 arg2Of elements,containing
R13021 T16011 T16006 arg1Of elements,either
R13022 T16011 T16007 arg1Of elements,NF-κB
R13023 T16011 T16009 arg1Of elements,AP-1
R13024 T16011 T16010 arg1Of elements,cis-acting
R13025 T16013 T16012 arg1Of cells,The
R13026 T16013 T16014 arg1Of cells,were
R13027 T16013 T16015 arg2Of cells,incubated
R13028 T16015 T16014 arg2Of incubated,were
R13029 T16015 T16016 arg1Of incubated,with
R13030 T16015 T16026 modOf incubated,followed
R13031 T16015 T16063 arg1Of incubated,but
R13032 T16019 T16016 arg2Of inhibitor,with
R13033 T16019 T16017 arg1Of inhibitor,NF-κB
R13034 T16019 T16018 arg1Of inhibitor,activation
R13035 T16019 T16020 arg1Of inhibitor,(
R13036 T16019 T16023 arg1Of inhibitor,for
R13037 T16021 T16020 arg2Of NAI,(
R13038 T16022 T16020 arg3Of ),(
R13039 T16025 T16023 arg2Of h,for
R13040 T16025 T16024 arg1Of h,1
R13041 T16028 T16026 arg1Of stimulation,followed
R13042 T16028 T16027 arg2Of stimulation,by
R13043 T16028 T16029 arg1Of stimulation,with
R13044 T16030 T16031 arg1Of PMA,(
R13045 T16030 T16039 arg1Of PMA,or
R13046 T16033 T16032 arg1Of nM,162
R13047 T16033 T16034 arg1Of nM,","
R13048 T16034 T16036 arg1Of ",",and
R13049 T16035 T16034 arg2Of A,","
R13050 T16036 T16031 arg2Of and,(
R13051 T16037 T16036 arg2Of C,and
R13052 T16038 T16031 arg3Of ),(
R13053 T16039 T16029 arg2Of or,with
R13054 T16042 T16040 arg1Of coli,HK
R13055 T16042 T16041 arg1Of coli,E.
R13056 T16042 T16043 arg1Of coli,(
R13057 T16042 T16053 arg1Of coli,for
R13058 T16042 T16056 arg1Of coli,(
R13059 T16047 T16048 arg1Of CFU/ml,","
R13060 T16048 T16050 arg1Of ",",and
R13061 T16049 T16048 arg2Of B,","
R13062 T16050 T16043 arg2Of and,(
R13063 T16050 T16044 arg1Of and,5
R13064 T16050 T16045 arg1Of and,×
R13065 T16050 T16046 arg1Of and,107
R13066 T16051 T16050 arg2Of D,and
R13067 T16052 T16043 arg3Of ),(
R13068 T16055 T16053 arg2Of h.,for
R13069 T16055 T16054 arg1Of h.,24
R13070 T16057 T16056 arg2Of A,(
R13071 T16057 T16058 arg1Of A,","
R13072 T16059 T16058 arg2Of B,","
R13073 T16060 T16056 arg3Of ),(
R13074 T16061 T16039 arg2Of NF-κB,or
R13075 T16061 T16042 arg1Of NF-κB,coli
R13076 T16063 T16062 arg1Of but,","
R13077 T16063 T16064 arg1Of but,not
R13078 T16066 T16065 arg2Of C,(
R13079 T16066 T16067 arg1Of C,","
R13080 T16068 T16067 arg2Of D,","
R13081 T16069 T16065 arg3Of ),(
R13082 T16070 T16065 arg1Of AP-1,(
R13083 T16070 T16071 arg1Of AP-1,was
R13084 T16070 T16072 arg2Of AP-1,inhibited
R13085 T16072 T16063 arg2Of inhibited,but
R13086 T16072 T16071 arg2Of inhibited,was
R13087 T16074 T16073 arg1Of significance,Statistical
R13088 T16074 T16075 arg1Of significance,from
R13089 T16074 T16084 arg1Of significance,was
R13090 T16074 T16085 arg2Of significance,determined
R13091 T16078 T16075 arg2Of control,from
R13092 T16078 T16076 arg1Of control,the
R13093 T16078 T16077 arg1Of control,positive
R13094 T16078 T16079 arg1Of control,(
R13095 T16082 T16079 arg2Of coli,(
R13096 T16082 T16080 arg1Of coli,PMA/HK
R13097 T16082 T16081 arg1Of coli,E.
R13098 T16083 T16079 arg3Of ),(
R13099 T16085 T16084 arg2Of determined,was
R13100 T16086 T16085 arg3Of using,determined
R13101 T16087 T16088 arg2Of Student,'s
R13102 T16089 T16086 arg2Of t-test.,using
R13103 T16089 T16088 arg1Of t-test.,'s
R13104 T16089 T16090 arg1Of t-test.,(
R13105 T16091 T16090 arg2Of n,(
R13106 T16091 T16092 arg1Of n,=
R13107 T16091 T16093 arg1Of n,4
R13108 T16094 T16090 arg3Of ),(
R13109 T16095 T16096 arg1Of Controls,were
R13110 T16095 T16097 arg2Of Controls,set
R13111 T16097 T16096 arg2Of set,were
R13112 T16097 T16098 arg1Of set,to
R13113 T16099 T16098 arg2Of 1,to
R13464 T16538 T16539 arg1Of Involvement,of
R13465 T16538 T16543 arg1Of Involvement,in
R13466 T16540 T16541 arg1Of PKC,and
R13467 T16541 T16539 arg2Of and,of
R13468 T16542 T16541 arg2Of JNK,and
R13469 T16545 T16543 arg2Of expression,in
R13470 T16545 T16544 arg1Of expression,cytokine
R13471 T16547 T16546 arg1Of T-cells,Jurkat
R13472 T16547 T16548 arg1Of T-cells,were
R13473 T16547 T16549 arg2Of T-cells,incubated
R13474 T16549 T16548 arg2Of incubated,were
R13475 T16549 T16550 arg1Of incubated,with
R13476 T16549 T16558 modOf incubated,followed
R13477 T16551 T16552 arg1Of PKC-,and
R13478 T16553 T16552 arg2Of JNK,and
R13479 T16554 T16550 arg2Of inhibitors,with
R13480 T16554 T16551 arg1Of inhibitors,PKC-
R13481 T16554 T16553 arg1Of inhibitors,JNK
R13482 T16554 T16555 arg1Of inhibitors,for
R13483 T16557 T16555 arg2Of h,for
R13484 T16557 T16556 arg1Of h,1
R13485 T16558 T16567 arg1Of followed,for
R13486 T16560 T16558 arg1Of stimulation,followed
R13487 T16560 T16559 arg2Of stimulation,by
R13488 T16560 T16561 arg1Of stimulation,with
R13489 T16562 T16561 arg2Of PMA,with
R13490 T16562 T16563 arg1Of PMA,(
R13491 T16565 T16563 arg2Of nM,(
R13492 T16565 T16564 arg1Of nM,162
R13493 T16566 T16563 arg3Of ),(
R13494 T16569 T16567 arg2Of h.,for
R13495 T16569 T16568 arg1Of h.,24
R13496 T16569 T16570 arg1Of h.,(
R13497 T16571 T16570 arg2Of A,(
R13498 T16572 T16570 arg3Of ),(
R13499 T16574 T16573 arg1Of expression,CXCL8
R13500 T16574 T16575 arg1Of expression,was
R13501 T16574 T16576 arg2Of expression,inhibited
R13502 T16576 T16575 arg2Of inhibited,was
R13503 T16576 T16577 arg1Of inhibited,in
R13504 T16580 T16577 arg2Of manner,in
R13505 T16580 T16578 arg1Of manner,a
R13506 T16580 T16579 arg1Of manner,dose-dependent
R13507 T16583 T16576 arg1Of inhibitors.,inhibited
R13508 T16583 T16581 arg2Of inhibitors.,by
R13509 T16583 T16582 arg1Of inhibitors.,both
R13510 T16583 T16584 arg1Of inhibitors.,(
R13511 T16585 T16584 arg2Of B,(
R13512 T16586 T16584 arg3Of ),(
R13513 T16587 T16588 arg1Of JNK-I,revealed
R13514 T16588 T16548 modOf revealed,were
R13515 T16588 T16575 modOf revealed,was
R13516 T16592 T16588 arg2Of effect,revealed
R13517 T16592 T16589 arg1Of effect,a
R13518 T16592 T16590 arg1Of effect,stronger
R13519 T16592 T16591 arg1Of effect,inhibitory
R13520 T16592 T16593 arg1Of effect,on
R13521 T16592 T16596 arg1Of effect,than
R13522 T16595 T16593 arg2Of expression,on
R13523 T16595 T16594 arg1Of expression,IL-6
R13524 T16600 T16599 arg2Of C,(
R13525 T16601 T16599 arg3Of ),(
R13526 T16603 T16597 arg1Of expression,the
R13527 T16603 T16598 arg1Of expression,PKC-I.
R13528 T16603 T16599 arg1Of expression,(
R13529 T16603 T16602 arg1Of expression,TNF
R13530 T16603 T16604 arg1Of expression,was
R13531 T16603 T16606 arg2Of expression,affected
R13532 T16606 T16596 arg2Of affected,than
R13533 T16606 T16604 arg2Of affected,was
R13534 T16606 T16605 arg1Of affected,not
R13535 T16609 T16606 arg1Of inhibitor,affected
R13536 T16609 T16607 arg2Of inhibitor,by
R13537 T16609 T16608 arg1Of inhibitor,either
R13538 T16611 T16610 arg1Of significance,Statistical
R13539 T16611 T16612 arg1Of significance,from
R13540 T16611 T16619 arg1Of significance,was
R13541 T16611 T16620 arg2Of significance,determined
R13542 T16615 T16612 arg2Of control,from
R13543 T16615 T16613 arg1Of control,the
R13544 T16615 T16614 arg1Of control,positive
R13545 T16615 T16616 arg1Of control,(
R13546 T16617 T16616 arg2Of PMA,(
R13547 T16618 T16616 arg3Of ),(
R13548 T16620 T16619 arg2Of determined,was
R13549 T16621 T16620 arg3Of using,determined
R13550 T16622 T16623 arg2Of Student,'s
R13551 T16624 T16621 arg2Of t-test.,using
R13552 T16624 T16623 arg1Of t-test.,'s
R13553 T16624 T16625 arg1Of t-test.,(
R13554 T16626 T16625 arg2Of n,(
R13555 T16626 T16627 arg1Of n,=
R13556 T16626 T16628 arg1Of n,3
R13557 T16629 T16625 arg3Of ),(
R13714 T16840 T16839 arg1Of inhibition,NF-κB
R13715 T16840 T16841 arg1Of inhibition,by
R13716 T16840 T16843 arg1Of inhibition,correlated
R13717 T16842 T16841 arg2Of PMA,by
R13718 T16843 T16844 arg1Of correlated,to
R13719 T16847 T16844 arg2Of degradation,to
R13720 T16847 T16845 arg1Of degradation,PKC-dependent
R13721 T16847 T16846 arg1Of degradation,Bcl10
R13722 T16848 T16849 arg1Of Levels,of
R13723 T16848 T16852 arg1Of Levels,were
R13724 T16848 T16853 arg2Of Levels,assessed
R13725 T16851 T16849 arg2Of protein,of
R13726 T16851 T16850 arg1Of protein,intracellular
R13727 T16853 T16852 arg2Of assessed,were
R13728 T16853 T16854 arg1Of assessed,following
R13729 T16853 T16878 arg2Of assessed,KC increa
R13730 T16857 T16855 arg1Of stimulation,24
R13731 T16857 T16856 arg1Of stimulation,h
R13732 T16857 T16858 arg1Of stimulation,with
R13733 T16857 T16864 arg1Of stimulation,or
R13734 T16859 T16858 arg2Of PMA,with
R13735 T16859 T16860 arg1Of PMA,(
R13736 T16862 T16860 arg2Of nM,(
R13737 T16862 T16861 arg1Of nM,162
R13738 T16863 T16860 arg3Of ),(
R13739 T16864 T16854 arg2Of or,following
R13740 T16864 T16874 arg1Of or,.
R13741 T16867 T16864 arg2Of coli,or
R13742 T16867 T16865 arg1Of coli,HK
R13743 T16867 T16866 arg1Of coli,E.
R13744 T16867 T16868 arg1Of coli,(
R13745 T16870 T16868 arg2Of ×,(
R13746 T16870 T16869 arg1Of ×,5
R13747 T16870 T16871 arg1Of ×,107
R13748 T16870 T16872 arg1Of ×,CFU/ml
R13749 T16873 T16868 arg3Of ),(
R13750 T16875 T16874 arg2Of (,.
R13751 T16876 T16874 arg3Of A,.
R13752 T16877 T16878 arg1Of ) Phospho-P,KC increa
R13753 T16878 T16879 arg1Of KC increa,se
R13754 T16878 T16893 arg1Of KC increa,IκB decre
R13755 T16878 T16899 modOf KC increa,ion with H
R13756 T16880 T16879 arg2Of d in res,se
R13757 T16880 T16881 arg1Of d in res,po
R13758 T16882 T16883 arg1Of nse,to
R13759 T16883 T16881 arg2Of to ,po
R13760 T16884 T16883 arg2Of PM,to
R13761 T16887 T16879 arg3Of HK E. coli s,se
R13762 T16887 T16885 arg1Of HK E. coli s,A
R13763 T16887 T16886 arg1Of HK E. coli s,and
R13764 T16887 T16888 arg1Of HK E. coli s,t
R13765 T16887 T16892 arg2Of HK E. coli s,tion. (B)
R13766 T16889 T16888 arg2Of i,t
R13767 T16890 T16888 arg3Of m,t
R13768 T16891 T16892 arg1Of ula,tion. (B)
R13769 T16894 T16893 arg2Of ased follow,IκB decre
R13770 T16894 T16895 arg1Of ased follow,ing
R13771 T16896 T16895 arg2Of st,ing
R13772 T16896 T16898 arg1Of st,ulat
R13773 T16898 T16897 arg1Of ulat,im
R13774 T16903 T16902 arg2Of i,t
R13775 T16904 T16902 arg3Of n,t
R13776 T16906 T16900 arg1Of κB activat,K E.
R13777 T16906 T16901 arg1Of κB activat,coli indica
R13778 T16906 T16902 arg1Of κB activat,t
R13779 T16906 T16905 arg1Of κB activat,g NF-
R13780 T16906 T16907 arg1Of κB activat,ion
R13781 T16906 T16908 arg2Of κB activat,. (C) Bcl
R13782 T16908 T16899 arg2Of . (C) Bcl,ion with H
R13783 T16908 T16907 arg2Of . (C) Bcl,ion
R13784 T16908 T16909 arg1Of . (C) Bcl,10 activa
R13785 T16911 T16909 arg2Of inhibited f,10 activa
R13786 T16911 T16910 arg1Of inhibited f,tion was
R13787 T16911 T16912 arg1Of inhibited f,ollo
R13788 T16911 T16914 arg1Of inhibited f,g
R13789 T16911 T16915 arg1Of inhibited f,long-
R13790 T16911 T16916 arg1Of inhibited f,term sti
R13791 T16913 T16912 arg2Of win,ollo
R13792 T16919 T16917 arg1Of "PMA, w",mul
R13793 T16919 T16918 arg1Of "PMA, w",ation with
R13794 T16919 T16920 arg1Of "PMA, w",hi
R13795 T16919 T16922 arg1Of "PMA, w",ex
R13796 T16919 T16926 arg1Of "PMA, w",ffe
R13797 T16919 T16927 arg2Of "PMA, w",ct o
R13798 T16921 T16920 arg2Of ch ,hi
R13799 T16925 T16922 arg2Of itory e,ex
R13800 T16925 T16923 arg1Of itory e,plain
R13801 T16925 T16924 arg1Of itory e,s the inhib
R13802 T16927 T16916 arg2Of ct o,term sti
R13803 T16927 T16926 arg2Of ct o,ffe
R13804 T16927 T16928 arg1Of ct o,f
R13805 T16927 T16932 arg1Of ct o,i
R13806 T16931 T16928 arg2Of F-κB act,f
R13807 T16931 T16929 arg1Of F-κB act,P
R13808 T16931 T16930 arg1Of F-κB act,MA on N
R13809 T16933 T16932 arg2Of v,i
R13810 T16933 T16934 arg1Of v,a
R13811 T16933 T16935 arg1Of v,t
R13812 T16936 T16932 arg3Of i,i
R13859 T17026 T17025 arg1Of T-cells,Jurkat
R13860 T17026 T17027 arg1Of T-cells,were
R13861 T17026 T17028 arg2Of T-cells,stimulated
R13862 T17028 T17027 arg2Of stimulated,were
R13863 T17028 T17029 arg1Of stimulated,with
R13864 T17028 T17041 arg1Of stimulated,for
R13865 T17030 T17031 arg1Of 162,nM
R13866 T17032 T17030 arg1Of PMA,162
R13867 T17032 T17033 arg1Of PMA,and
R13868 T17033 T17029 arg2Of and,with
R13869 T17040 T17033 arg2Of coli,and
R13870 T17040 T17034 arg1Of coli,5
R13871 T17040 T17035 arg1Of coli,×
R13872 T17040 T17036 arg1Of coli,107
R13873 T17040 T17037 arg1Of coli,CFU/ml
R13874 T17040 T17038 arg1Of coli,HK
R13875 T17040 T17039 arg1Of coli,E.
R13876 T17043 T17041 arg2Of h,for
R13877 T17043 T17042 arg1Of h,24
R13906 T17076 T17075 arg1Of T-cells,Jurkat
R13907 T17076 T17077 arg1Of T-cells,were
R13908 T17076 T17078 arg2Of T-cells,treated
R13909 T17078 T17077 arg2Of treated,were
R13910 T17078 T17079 arg1Of treated,with
R13911 T17078 T17093 modOf treated,followed
R13912 T17080 T17081 arg1Of 10,nM
R13913 T17082 T17080 arg1Of NAI,10
R13914 T17082 T17083 arg1Of NAI,","
R13915 T17083 T17079 arg2Of ",",with
R13916 T17083 T17090 arg1Of ",",for
R13917 T17089 T17083 arg2Of PKC-I,","
R13918 T17089 T17084 arg1Of PKC-I,10
R13919 T17089 T17085 arg1Of PKC-I,μM
R13920 T17089 T17086 arg1Of PKC-I,JNK-I
R13921 T17089 T17087 arg1Of PKC-I,or10
R13922 T17089 T17088 arg1Of PKC-I,nM
R13923 T17092 T17090 arg2Of h,for
R13924 T17092 T17091 arg1Of h,2
R13925 T17095 T17093 arg1Of induction,followed
R13926 T17095 T17094 arg2Of induction,by
R13927 T17095 T17096 arg1Of induction,with
R13928 T17097 T17098 arg1Of 162,nM
R13929 T17099 T17096 arg2Of PMA,with
R13930 T17099 T17097 arg1Of PMA,162
R13931 T17099 T17100 arg1Of PMA,for
R13932 T17102 T17100 arg2Of h,for
R13933 T17102 T17101 arg1Of h,24

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T16309 7102-7112 Anaphor denotes the levels
T16310 7020-7030 Antecedent denotes expression
T5509 8679-8689 Anaphor denotes the levels
T5510 8633-8639 Antecedent denotes levels
T4372 4288-4301 Anaphor denotes the cytokines
T4373 4157-4162 Antecedent denotes CXCL8
T4374 4213-4217 Antecedent denotes IL-6
R13287 T16309 T16310 boundBy the levels,expression
R4559 T5509 T5510 boundBy the levels,levels
R3611 T4372 T4373 boundBy the cytokines,CXCL8
R3612 T4372 T4374 boundBy the cytokines,IL-6

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T3063 339-348 NN denotes induction
T3068 32-37 NNP denotes NF-κB
T3069 38-48 NN denotes activation
T3070 49-52 DT denotes The
T3071 53-66 NN denotes transcription
T3072 67-74 NNS denotes factors
T3073 75-80 NNP denotes NF-κB
T3074 81-84 CC denotes and
T3075 85-89 NNP denotes AP-1
T3076 90-94 VBP denotes play
T3077 95-98 JJ denotes key
T3078 99-104 NNS denotes roles
T3079 105-107 IN denotes in
T3080 108-111 DT denotes the
T3081 112-122 NN denotes initiation
T3082 123-125 IN denotes of
T3083 126-128 DT denotes an
T3084 129-141 JJ denotes inflammatory
T3085 142-150 NN denotes response
T3086 151-153 IN denotes by
T3087 154-162 VBG denotes inducing
T3088 163-166 DT denotes the
T3089 167-177 NN denotes expression
T3090 178-181 CC denotes and
T3091 182-191 NN denotes secretion
T3092 192-194 IN denotes of
T3093 195-205 NNS denotes chemokines
T3094 206-209 CC denotes and
T3095 210-219 NNS denotes cytokines
T3096 220-224 WDT denotes that
T3097 225-232 VBP denotes attract
T3098 233-236 CC denotes and
T3099 237-245 VBP denotes activate
T3100 246-252 JJ denotes immune
T3101 253-258 NNS denotes cells
T3102 258-259 . denotes .
T3103 260-267 RB denotes However
T3104 267-268 , denotes ,
T3105 269-272 DT denotes the
T3106 273-279 NN denotes signal
T3107 280-292 NN denotes transduction
T3108 293-301 NNS denotes pathways
T3109 302-305 CC denotes and
T3110 306-316 JJ denotes subsequent
T3111 317-329 JJ denotes inflammatory
T3112 330-338 NN denotes cytokine
T3113 349-351 IN denotes by
T3114 352-357 DT denotes these
T3115 358-371 NN denotes transcription
T3116 372-379 NNS denotes factors
T3117 380-382 VBZ denotes is
T3118 383-386 RB denotes not
T3119 387-392 RB denotes fully
T3120 393-403 VBN denotes elucidated
T3121 403-404 . denotes .
T3122 405-408 DT denotes The
T3123 409-416 JJ denotes present
T3124 417-422 NN denotes study
T3125 423-425 VBZ denotes is
T3126 426-431 VBN denotes aimed
T3127 432-434 IN denotes at
T3128 435-446 VBG denotes determining
T3129 447-450 DT denotes the
T3130 451-462 NN denotes involvement
T3131 463-465 IN denotes of
T3132 466-470 NN denotes AP-1
T3133 471-474 CC denotes and
T3134 475-480 NN denotes NF-κB
T3135 481-483 IN denotes in
T3136 484-492 NN denotes cytokine
T3137 493-502 NN denotes induction
T3138 503-506 CC denotes and
T3139 507-517 NN denotes regulation
T3140 517-518 . denotes .
T3141 519-522 NNP denotes PMA
T3142 523-532 NN denotes treatment
T3143 533-541 VBD denotes resulted
T3144 542-544 IN denotes in
T3145 545-547 DT denotes an
T3146 548-561 NN denotes up-regulation
T3147 562-564 IN denotes of
T3148 565-569 NN denotes AP-1
T3149 570-575 IN denotes after
T3150 576-577 CD denotes 2
T3151 578-579 NN denotes h
T3152 580-588 NN denotes exposure
T3153 589-592 CC denotes and
T3154 593-602 VBD denotes continued
T3155 603-605 TO denotes to
T3157 615-625 IN denotes throughout
T3158 626-629 DT denotes the
T3159 630-638 NN denotes analysis
T3160 639-645 NN denotes period
T3161 646-647 -LRB- denotes (
T3162 647-653 NN denotes figure
T3163 654-656 NNS denotes 1a
T3164 656-657 -RRB- denotes )
T3165 657-658 . denotes .
T3166 659-661 NNP denotes HK
T3167 662-664 NNP denotes E.
T3168 665-669 NNS denotes coli
T3169 670-679 NN denotes treatment
T3170 680-683 VBD denotes did
T3171 684-687 RB denotes not
T3173 695-699 JJ denotes AP-1
T3174 700-710 NN denotes activation
T3175 711-713 IN denotes in
T3176 714-720 NNP denotes Jurkat
T3177 721-728 NNS denotes T-cells
T3178 729-730 -LRB- denotes (
T3179 730-736 NN denotes figure
T3180 737-739 CD denotes 1b
T3181 739-740 -RRB- denotes )
T3182 740-741 . denotes .
T3183 742-744 TO denotes To
T3184 745-754 VB denotes determine
T3185 755-758 DT denotes the
T3186 759-770 NN denotes involvement
T3187 771-773 IN denotes of
T3188 774-784 VBN denotes associated
T3189 785-793 NNS denotes pathways
T3190 793-794 , denotes ,
T3191 795-797 PRP denotes we
T3192 798-805 VBD denotes exposed
T3193 806-811 NNS denotes cells
T3194 812-814 TO denotes to
T3195 815-818 JJ denotes Ca2
T3196 818-819 NN denotes +
T3197 820-829 NN denotes ionophore
T3198 830-834 IN denotes with
T3199 835-837 CC denotes or
T3200 838-845 IN denotes without
T3201 846-849 NNP denotes PMA
T3202 850-853 CC denotes and
T3203 854-862 VBD denotes observed
T3204 863-864 DT denotes a
T3205 865-871 JJ denotes modest
T3206 872-883 NN denotes involvement
T3207 884-886 IN denotes of
T3208 887-890 NNP denotes Ca2
T3209 890-891 NNP denotes +
T3210 892-894 IN denotes in
T3211 895-908 NNP denotes PMA-dependent
T3212 909-913 NNP denotes AP-1
T3213 914-924 NN denotes activation
T3214 925-926 -LRB- denotes (
T3215 926-932 NN denotes figure
T3216 933-935 CD denotes 1c
T3217 935-936 -RRB- denotes )
T3218 937-942 IN denotes while
T3219 943-946 NNP denotes Ca2
T3220 946-947 NNP denotes +
T3221 948-953 RB denotes alone
T3222 954-957 VBD denotes did
T3223 958-961 RB denotes not
T3224 962-967 VB denotes alter
T3225 968-972 JJ denotes AP-1
T3226 973-981 NN denotes activity
T3227 982-983 -LRB- denotes (
T3228 983-987 NNS denotes data
T3229 988-991 RB denotes not
T3230 992-997 VBN denotes shown
T3231 997-998 -RRB- denotes )
T3232 998-999 . denotes .
T3233 1000-1011 RB denotes Furthermore
T3234 1011-1012 , denotes ,
T3235 1013-1017 JJ denotes AP-1
T3236 1018-1026 NN denotes activity
T3237 1027-1036 VBN denotes decreased
T3238 1037-1039 IN denotes in
T3239 1040-1041 DT denotes a
T3240 1042-1055 JJ denotes TCR-deficient
T3241 1056-1062 NNP denotes Jurkat
T3242 1063-1067 NN denotes cell
T3243 1068-1072 NN denotes line
T3244 1073-1077 WRB denotes when
T3245 1078-1085 VBN denotes exposed
T3246 1086-1088 TO denotes to
T3247 1089-1092 NNP denotes PMA
T3248 1093-1101 VBN denotes compared
T3249 1102-1104 TO denotes to
T3250 1105-1108 DT denotes the
T3251 1109-1115 NN denotes parent
T3252 1116-1120 NN denotes cell
T3253 1121-1125 NN denotes line
T3254 1126-1136 VBG denotes indicating
T3255 1137-1141 IN denotes that
T3256 1142-1152 NN denotes regulation
T3257 1153-1155 IN denotes of
T3258 1156-1160 NN denotes AP-1
T3259 1161-1164 VBD denotes was
T3260 1165-1169 RB denotes only
T3261 1170-1179 RB denotes partially
T3262 1180-1186 NN denotes T-cell
T3263 1187-1195 NN denotes receptor
T3264 1196-1205 JJ denotes dependent
T3265 1206-1207 -LRB- denotes (
T3266 1207-1213 NN denotes figure
T3267 1214-1216 CD denotes 1d
T3268 1216-1217 -RRB- denotes )
T3269 1217-1218 . denotes .
T3270 1856-1861 NN denotes NF-κB
T3271 1862-1868 NNS denotes levels
T3272 1869-1875 VBD denotes showed
T3273 1876-1877 DT denotes a
T3274 1921-1923 TO denotes to
T3275 1878-1887 JJ denotes transient
T3276 1888-1896 NN denotes increase
T3277 1897-1899 IN denotes at
T3278 1900-1901 CD denotes 1
T3279 1902-1905 NN denotes min
T3280 1906-1911 IN denotes after
T3281 1912-1920 NN denotes exposure
T3282 1924-1927 NNP denotes PMA
T3283 1928-1929 -LRB- denotes (
T3284 1929-1935 NN denotes figure
T3285 1936-1938 NN denotes 2a
T3286 1938-1939 -RRB- denotes )
T3287 1939-1940 . denotes .
T3288 1941-1948 RB denotes However
T3289 1948-1949 , denotes ,
T3290 1950-1951 CD denotes 1
T3291 1952-1953 NN denotes h
T3292 1954-1959 IN denotes after
T3293 1960-1968 NN denotes exposure
T3294 1969-1972 DT denotes the
T3295 1973-1978 NN denotes NF-κB
T3296 1979-1985 NNS denotes levels
T3297 1986-1991 VBD denotes began
T3298 1992-1994 TO denotes to
T3299 1995-1999 VB denotes drop
T3300 2000-2008 VBG denotes reaching
T3301 2009-2012 DT denotes the
T3302 2013-2019 JJS denotes lowest
T3303 2020-2026 NNS denotes levels
T3304 2027-2029 IN denotes by
T3305 2030-2031 CD denotes 6
T3306 2032-2033 NN denotes h
T3307 2033-2034 , denotes ,
T3308 2035-2040 IN denotes after
T3309 2041-2046 WDT denotes which
T3310 2047-2051 PRP denotes they
T3311 2052-2061 VBD denotes increased
T3312 2062-2067 RB denotes again
T3313 2068-2070 IN denotes by
T3314 2071-2073 CD denotes 24
T3315 2074-2076 NN denotes h.
T3316 2077-2085 NN denotes Exposure
T3317 2086-2088 IN denotes of
T3318 2089-2095 NNP denotes Jurkat
T3319 2096-2103 NNS denotes T-cells
T3320 2104-2106 TO denotes to
T3321 2107-2109 NNP denotes HK
T3322 2110-2112 NNP denotes E.
T3323 2113-2117 NNS denotes coli
T3324 2118-2126 VBD denotes resulted
T3325 2127-2129 IN denotes in
T3326 2130-2131 DT denotes a
T3327 2132-2146 JJ denotes dose-dependent
T3328 2147-2152 NN denotes NF-κB
T3329 2153-2163 NN denotes activation
T3330 2163-2164 , denotes ,
T3331 2165-2169 IN denotes with
T3332 2170-2173 DT denotes the
T3333 2174-2181 JJS denotes highest
T3334 2182-2190 NN denotes activity
T3335 2191-2199 VBD denotes observed
T3336 2200-2202 IN denotes at
T3337 2203-2204 DT denotes a
T3338 2205-2213 JJ denotes relative
T3339 2214-2227 NN denotes concentration
T3340 2228-2230 IN denotes of
T3341 2231-2232 CD denotes 5
T3342 2233-2234 CD denotes ×
T3343 2235-2238 CD denotes 107
T3344 2239-2245 NNP denotes CFU/ml
T3345 2246-2247 -LRB- denotes (
T3346 2247-2253 NN denotes figure
T3347 2254-2256 NN denotes 2b
T3348 2256-2257 -RRB- denotes )
T3349 2257-2258 . denotes .
T3350 2259-2262 DT denotes The
T3351 2263-2277 JJ denotes time-dependent
T3353 2289-2291 IN denotes of
T3354 2292-2297 NN denotes NF-κB
T3355 2298-2300 IN denotes by
T3356 2301-2303 NNP denotes HK
T3357 2304-2306 NNP denotes E.
T3358 2307-2311 NNS denotes coli
T3359 2312-2315 VBD denotes was
T3360 2316-2324 VBN denotes assessed
T3361 2325-2332 RBR denotes further
T3362 2333-2338 VBG denotes using
T3363 2339-2342 DT denotes the
T3364 2343-2350 JJ denotes optimal
T3365 2351-2364 NN denotes concentration
T3366 2365-2373 VBN denotes obtained
T3367 2374-2378 IN denotes from
T3368 2379-2385 NN denotes figure
T3369 2386-2388 CD denotes 2b
T3370 2389-2392 CC denotes and
T3371 2393-2399 VBD denotes showed
T3372 2400-2404 IN denotes that
T3373 2405-2408 DT denotes the
T3374 2409-2414 JJ denotes NF-κB
T3375 2415-2423 NN denotes activity
T3376 2424-2433 VBN denotes increased
T3377 2434-2439 IN denotes after
T3378 2440-2441 CD denotes 3
T3379 2442-2443 NN denotes h
T3380 2444-2446 IN denotes of
T3381 2447-2455 NN denotes exposure
T3382 2456-2457 -LRB- denotes (
T3383 2457-2463 NN denotes figure
T3384 2464-2466 JJ denotes 2c
T3385 2466-2467 -RRB- denotes )
T3386 2467-2468 . denotes .
T3387 2469-2480 RB denotes Furthermore
T3388 2480-2481 , denotes ,
T3389 2482-2491 VBD denotes increased
T3390 2492-2505 JJ denotes intracellular
T3391 2506-2509 NNP denotes Ca2
T3392 2509-2510 NN denotes +
T3393 2511-2519 VBD denotes reversed
T3394 2520-2523 DT denotes the
T3395 2524-2527 NNP denotes PMA
T3396 2528-2537 JJ denotes dependent
T3397 2538-2543 NN denotes NF-κB
T3398 2544-2554 NN denotes inhibition
T3399 2555-2556 -LRB- denotes (
T3400 2556-2562 NN denotes figure
T3401 2563-2565 CD denotes 2d
T3402 2565-2566 -RRB- denotes )
T3403 2567-2570 CC denotes and
T3404 2571-2578 VBD denotes reduced
T3405 2579-2582 DT denotes the
T3406 2583-2585 NNP denotes HK
T3407 2586-2588 NNP denotes E.
T3408 2589-2593 NNS denotes coli
T3409 2594-2595 : denotes -
T3410 2595-2604 JJ denotes dependent
T3411 2605-2610 JJ denotes NF-κB
T3412 2611-2621 NN denotes activation
T3413 2622-2623 -LRB- denotes (
T3414 2623-2629 NN denotes figure
T3415 2630-2632 CD denotes 2e
T3416 2632-2633 -RRB- denotes )
T3417 2633-2634 . denotes .
T3942 3425-3434 VBN denotes evaluated
T3943 3353-3356 CC denotes and
T3944 3298-3307 NNP denotes Induction
T3945 3308-3310 IN denotes of
T3946 3311-3323 JJ denotes inflammatory
T3947 3324-3333 NNS denotes responses
T3948 3334-3337 DT denotes The
T3949 3338-3345 NN denotes ability
T3950 3346-3348 IN denotes of
T3951 3349-3352 NNP denotes PMA
T3952 3357-3359 NNP denotes HK
T3953 3360-3362 NNP denotes E.
T3954 3363-3367 NNS denotes coli
T3955 3368-3370 TO denotes to
T3956 3371-3377 VB denotes induce
T3957 3378-3380 DT denotes an
T3958 3381-3393 JJ denotes inflammatory
T3959 3394-3402 NN denotes response
T3960 3403-3405 IN denotes in
T3961 3406-3412 NNP denotes Jurkat
T3962 3413-3420 NNS denotes T-cells
T3963 3421-3424 VBD denotes was
T3964 3435-3440 VBG denotes using
T3965 3441-3442 DT denotes a
T3966 3443-3452 JJ denotes multiplex
T3967 3453-3461 NN denotes cytokine
T3968 3462-3467 NN denotes assay
T3969 3468-3477 VBG denotes following
T3970 3478-3480 CD denotes 24
T3971 3481-3482 NN denotes h
T3972 3483-3494 NN denotes stimulation
T3973 3494-3495 . denotes .
T3974 3496-3499 DT denotes The
T3975 3500-3508 NN denotes cytokine
T3976 3509-3516 NN denotes profile
T3977 3517-3525 VBD denotes revealed
T3978 3526-3528 DT denotes an
T3979 3529-3537 JJ denotes enhanced
T3980 3538-3547 NN denotes induction
T3981 3548-3550 IN denotes of
T3982 3551-3554 DT denotes the
T3983 3555-3571 JJ denotes pro-inflammatory
T3984 3572-3581 NNS denotes cytokines
T3985 3582-3586 NN denotes IL-2
T3986 3586-3587 , denotes ,
T3987 3588-3592 NNP denotes IL-6
T3988 3592-3593 , denotes ,
T3989 3594-3597 NNP denotes TNF
T3990 3598-3601 CC denotes and
T3991 3602-3605 DT denotes the
T3992 3606-3615 NN denotes chemokine
T3993 3616-3621 NNP denotes CXCL8
T3994 3621-3622 . denotes .
T3995 3623-3626 DT denotes The
T3996 3627-3633 NNS denotes levels
T3997 3634-3636 IN denotes of
T3998 3637-3640 DT denotes the
T3999 3641-3658 JJ denotes anti-inflammatory
T4000 3659-3667 NN denotes cytokine
T4001 3668-3673 NN denotes IL-10
T4002 3674-3678 VBD denotes were
T4003 3679-3689 JJ denotes unaffected
T4004 3690-3692 IN denotes by
T4005 3693-3696 NNP denotes PMA
T4006 3697-3700 CC denotes but
T4007 3701-3705 VBD denotes were
T4008 3706-3719 RB denotes significantly
T4009 3720-3729 VBN denotes decreased
T4010 3730-3732 IN denotes by
T4011 3733-3735 NNP denotes HK
T4012 3736-3738 NNP denotes E.
T4013 3739-3743 NNS denotes coli
T4014 3744-3745 -LRB- denotes (
T4015 3745-3750 NNP denotes Table
T4016 3751-3752 CD denotes 1
T4017 3752-3753 -RRB- denotes )
T4018 3753-3754 . denotes .
T4019 3755-3760 DT denotes These
T4020 3761-3768 NNS denotes results
T4021 3769-3778 VBD denotes confirmed
T4022 3779-3783 IN denotes that
T4023 3784-3787 NNP denotes PMA
T4024 3788-3791 CC denotes and
T4025 3792-3794 NNP denotes HK
T4026 3795-3797 NNP denotes E.
T4027 3798-3802 NNS denotes coli
T4028 3803-3810 VBD denotes induced
T4029 3811-3813 DT denotes an
T4030 3814-3826 JJ denotes inflammatory
T4031 3827-3835 NN denotes response
T4032 3836-3838 IN denotes in
T4033 3839-3842 DT denotes the
T4034 3843-3849 NNP denotes Jurkat
T4035 3850-3857 NNS denotes T-cells
T4036 3857-3858 . denotes .
T4037 3859-3861 PRP denotes It
T4038 3862-3864 VBZ denotes is
T4039 3865-3876 JJ denotes interesting
T4040 3877-3879 TO denotes to
T4041 3880-3884 VB denotes note
T4042 3885-3889 IN denotes that
T4043 3890-3893 NNP denotes PMA
T4044 3894-3897 VBD denotes was
T4045 3898-3906 JJ denotes 120-fold
T4046 3907-3911 RBR denotes more
T4047 3912-3921 JJ denotes effective
T4048 3922-3924 IN denotes at
T4049 3925-3933 VBG denotes inducing
T4050 3934-3939 NNP denotes CXCL8
T4051 3940-3944 IN denotes than
T4052 3945-3947 NNP denotes HK
T4053 3948-3950 NNP denotes E.
T4054 3951-3955 NNS denotes coli
T4055 3955-3956 . denotes .
T4056 3957-3970 JJ denotes PMA-dependent
T4057 3971-3980 NN denotes induction
T4058 3981-3983 IN denotes of
T4059 3984-3988 NN denotes AP-1
T4060 3989-3992 CC denotes and
T4061 3993-4008 NN denotes down-regulation
T4062 4009-4011 IN denotes of
T4063 4012-4017 NN denotes NF-κB
T4064 4018-4026 VBZ denotes suggests
T4065 4027-4029 DT denotes an
T4066 4030-4041 NN denotes involvement
T4067 4042-4044 IN denotes of
T4068 4045-4049 NN denotes AP-1
T4069 4050-4052 IN denotes in
T4070 4053-4058 CD denotes CXCL8
T4071 4059-4069 NN denotes regulation
T4072 4069-4070 . denotes .
T4073 4071-4084 NN denotes Determination
T4074 4085-4087 IN denotes of
T4075 4088-4091 DT denotes the
T4076 4092-4096 NN denotes time
T4077 4097-4103 NN denotes course
T4078 4104-4106 IN denotes of
T4079 4107-4115 NN denotes cytokine
T4080 4116-4125 NN denotes induction
T4081 4126-4128 IN denotes in
T4082 4129-4137 NN denotes response
T4083 4138-4140 TO denotes to
T4084 4141-4144 NNP denotes PMA
T4085 4145-4151 VBD denotes showed
T4086 4152-4156 IN denotes that
T4087 4157-4162 NNP denotes CXCL8
T4088 4163-4166 VBD denotes was
T4089 4167-4174 RB denotes already
T4090 4175-4183 VBN denotes released
T4091 4184-4191 IN denotes between
T4092 4192-4195 CD denotes 2-6
T4093 4196-4197 NN denotes h
T4094 4197-4198 , denotes ,
T4095 4199-4204 IN denotes while
T4096 4205-4208 NNP denotes TNF
T4097 4209-4212 CC denotes and
T4098 4213-4217 NNP denotes IL-6
T4099 4218-4222 VBD denotes were
T4100 4223-4231 VBN denotes released
T4101 4232-4239 IN denotes between
T4102 4240-4244 CD denotes 6-24
T4103 4245-4246 NN denotes h
T4104 4247-4248 -LRB- denotes (
T4105 4248-4254 NN denotes figure
T4106 4255-4256 CD denotes 3
T4107 4256-4257 -RRB- denotes )
T4108 4257-4258 . denotes .
T4109 4259-4264 DT denotes These
T4110 4265-4272 NNS denotes results
T4111 4273-4282 VBD denotes indicated
T4112 4283-4287 IN denotes that
T4113 4288-4291 DT denotes the
T4114 4292-4301 NNS denotes cytokines
T4115 4302-4306 VBD denotes were
T4116 4307-4321 RB denotes differentially
T4117 4322-4331 VBN denotes regulated
T4118 4332-4335 CC denotes and
T4119 4336-4340 IN denotes that
T4120 4341-4344 DT denotes the
T4121 4345-4352 NN denotes release
T4122 4353-4356 VBD denotes was
T4123 4357-4360 RB denotes not
T4124 4361-4371 VBN denotes associated
T4125 4372-4376 IN denotes with
T4126 4377-4380 DT denotes the
T4127 4381-4386 JJ denotes early
T4128 4387-4396 NN denotes transient
T4129 4397-4406 NN denotes induction
T4130 4407-4409 IN denotes of
T4131 4410-4415 NN denotes NF-κB
T4132 4415-4416 . denotes .
T4133 4417-4420 DT denotes The
T4134 4421-4429 JJ denotes temporal
T4135 4430-4439 NN denotes induction
T4136 4440-4442 IN denotes of
T4137 4443-4447 JJ denotes AP-1
T4139 4459-4461 TO denotes to
T4140 4462-4465 DT denotes the
T4141 4466-4471 NNP denotes CXCL8
T4142 4472-4478 NNS denotes levels
T4143 4479-4482 CC denotes and
T4144 4483-4491 VBD denotes preceded
T4145 4492-4495 DT denotes the
T4146 4496-4499 NNP denotes TNF
T4147 4500-4503 CC denotes and
T4148 4504-4508 NNP denotes IL-6
T4149 4509-4516 NN denotes release
T4150 4516-4517 . denotes .
T4151 4518-4522 DT denotes This
T4152 4523-4531 VBZ denotes suggests
T4153 4532-4534 DT denotes an
T4154 4535-4546 NN denotes association
T4155 4547-4554 IN denotes between
T4156 4555-4560 CD denotes CXCL8
T4157 4561-4568 NN denotes release
T4158 4569-4572 CC denotes and
T4159 4573-4577 JJ denotes AP-1
T4160 4578-4588 NN denotes signalling
T4161 4588-4589 . denotes .
T4767 5410-5421 NNP denotes Cooperative
T4768 5422-5431 NN denotes induction
T4769 5432-5434 IN denotes of
T4770 5435-5444 NNS denotes cytokines
T4771 5445-5447 IN denotes by
T4772 5448-5452 NNP denotes AP-1
T4773 5453-5456 CC denotes and
T4774 5457-5462 NNP denotes NF-κB
T4775 5463-5465 TO denotes To
T4776 5466-5473 RBR denotes further
T4777 5474-5486 VB denotes characterize
T4778 5487-5490 DT denotes the
T4779 5491-5502 NN denotes involvement
T4780 5503-5505 IN denotes of
T4783 5515-5523 NN denotes cytokine
T4784 5524-5534 NN denotes regulation
T4785 5534-5535 , denotes ,
T4786 5536-5538 PRP denotes we
T4787 5539-5546 VBD denotes treated
T4788 5547-5552 NNS denotes cells
T4789 5553-5557 IN denotes with
T4790 5558-5560 DT denotes an
T4791 5561-5566 JJ denotes NF-κB
T4792 5567-5577 NN denotes activation
T4793 5578-5587 NN denotes inhibitor
T4794 5588-5589 -LRB- denotes (
T4795 5589-5592 NNP denotes NAI
T4796 5592-5593 -RRB- denotes )
T4797 5593-5594 . denotes .
T4798 5595-5598 DT denotes The
T4799 5599-5606 NNS denotes results
T4800 5607-5613 VBD denotes showed
T4801 5614-5618 IN denotes that
T4802 5619-5622 NNP denotes NAI
T4803 5623-5634 RB denotes selectively
T4804 5635-5649 VBD denotes down-regulated
T4805 5650-5655 JJ denotes NF-κB
T4806 5656-5666 NN denotes activation
T4807 5667-5668 -LRB- denotes (
T4808 5668-5675 NNS denotes figures
T4809 5676-5678 VBP denotes 4a
T4810 5679-5682 CC denotes and
T4811 5683-5685 VBP denotes 4b
T4812 5685-5686 -RRB- denotes )
T4813 5687-5690 CC denotes and
T4814 5691-5694 VBD denotes did
T4815 5695-5698 RB denotes not
T4816 5699-5704 VB denotes alter
T4817 5705-5709 JJ denotes AP-1
T4818 5710-5718 NN denotes activity
T4819 5719-5720 -LRB- denotes (
T4820 5720-5727 NNS denotes figures
T4821 5728-5730 VBP denotes 4c
T4822 5731-5734 CC denotes and
T4823 5735-5737 VBP denotes 4d
T4824 5737-5738 -RRB- denotes )
T4825 5738-5739 . denotes .
T4826 5740-5748 NN denotes Exposure
T4827 5749-5751 IN denotes of
T4828 5752-5758 NNP denotes Jurkat
T4829 5759-5766 NNS denotes T-cells
T4830 5767-5769 TO denotes to
T4831 5770-5773 NNP denotes NAI
T4832 5774-5782 VBD denotes resulted
T4833 5783-5785 IN denotes in
T4834 5786-5787 DT denotes a
T4835 5788-5794 JJ denotes modest
T4836 5795-5804 NN denotes reduction
T4837 5805-5807 IN denotes of
T4838 5808-5813 NNP denotes CXCL8
T4839 5814-5823 VBG denotes following
T4840 5824-5827 NNP denotes PMA
T4841 5828-5836 NN denotes exposure
T4842 5836-5837 , denotes ,
T4843 5838-5843 IN denotes while
T4844 5844-5846 PRP denotes it
T4845 5847-5850 VBD denotes did
T4846 5851-5854 RB denotes not
T4847 5855-5860 VB denotes alter
T4848 5861-5864 DT denotes the
T4849 5865-5870 NNP denotes CXCL8
T4850 5871-5878 NN denotes release
T4851 5879-5888 VBG denotes following
T4852 5889-5891 NNP denotes HK
T4853 5892-5894 NNP denotes E.
T4854 5895-5899 NNS denotes coli
T4855 5900-5908 NN denotes exposure
T4856 5909-5910 -LRB- denotes (
T4857 5910-5916 NN denotes figure
T4858 5917-5919 NN denotes 5a
T4859 5919-5920 -RRB- denotes )
T4860 5920-5921 . denotes .
T4861 5922-5925 NNP denotes NAI
T4862 5926-5929 VBD denotes did
T4863 5930-5933 RB denotes not
T4864 5934-5940 VB denotes affect
T4865 5941-5944 NNP denotes TNF
T4866 5945-5955 NN denotes expression
T4867 5956-5957 -LRB- denotes (
T4868 5957-5963 NN denotes figure
T4869 5964-5966 NN denotes 5b
T4870 5966-5967 -RRB- denotes )
T4871 5968-5978 VBG denotes indicating
T4872 5979-5983 IN denotes that
T4873 5984-5989 NNP denotes NF-κB
T4874 5990-5992 VBZ denotes is
T4875 5993-5996 RB denotes not
T4876 5997-6000 DT denotes the
T4877 6001-6005 JJ denotes main
T4878 6006-6015 NN denotes regulator
T4879 6016-6018 IN denotes of
T4880 6019-6024 CD denotes CXCL8
T4881 6025-6027 CC denotes or
T4882 6028-6031 NNP denotes TNF
T4883 6032-6041 VBG denotes following
T4884 6042-6048 CC denotes either
T4885 6049-6052 NNP denotes PMA
T4886 6053-6055 CC denotes or
T4887 6056-6058 NNP denotes HK
T4888 6059-6061 NNP denotes E.
T4889 6062-6066 NNS denotes coli
T4890 6067-6075 NN denotes exposure
T4891 6076-6078 IN denotes in
T4892 6079-6085 NNP denotes Jurkat
T4893 6086-6093 NNS denotes T-cells
T4894 6093-6094 . denotes .
T4895 6095-6097 IN denotes In
T4896 6098-6106 NN denotes contrast
T4897 6106-6107 , denotes ,
T4898 6108-6111 NNP denotes NAI
T4899 6112-6120 VBD denotes resulted
T4900 6121-6123 IN denotes in
T4901 6124-6125 DT denotes a
T4902 6126-6134 JJ denotes complete
T4903 6135-6145 NN denotes inhibition
T4904 6146-6148 IN denotes of
T4905 6149-6153 NN denotes IL-6
T4906 6154-6163 VBG denotes following
T4907 6164-6167 NNP denotes PMA
T4908 6168-6176 NN denotes exposure
T4909 6177-6180 CC denotes and
T4910 6181-6182 DT denotes a
T4911 6183-6185 CD denotes 45
T4912 6185-6186 NN denotes %
T4913 6187-6197 NN denotes inhibition
T4914 6198-6207 VBG denotes following
T4915 6208-6210 NNP denotes HK
T4916 6211-6213 NNP denotes E.
T4917 6214-6218 NNS denotes coli
T4918 6219-6227 NN denotes exposure
T4919 6228-6229 -LRB- denotes (
T4920 6229-6235 NN denotes figure
T4921 6236-6238 NN denotes 5c
T4922 6238-6239 -RRB- denotes )
T4923 6239-6240 , denotes ,
T4924 6241-6251 VBG denotes suggesting
T4925 6252-6254 DT denotes an
T4926 6255-6266 NN denotes involvement
T4927 6267-6269 IN denotes of
T4928 6270-6275 NNP denotes NF-κB
T4929 6276-6278 IN denotes in
T4930 6279-6283 NNP denotes IL-6
T4931 6284-6294 NN denotes regulation
T4932 6294-6295 . denotes .
T4933 7593-7596 CD denotes Ca2
T4934 7596-7597 NN denotes +
T4935 7598-7601 VBD denotes was
T4936 7602-7610 VBN denotes observed
T4937 7611-7613 TO denotes to
T4938 7614-7622 VB denotes increase
T4939 7623-7627 JJ denotes AP-1
T4940 7628-7636 NN denotes activity
T4941 7637-7638 -LRB- denotes (
T4942 7638-7644 NN denotes figure
T4943 7645-7647 CD denotes 1c
T4944 7647-7648 -RRB- denotes )
T4945 7649-7652 CC denotes and
T4946 7653-7659 VB denotes reduce
T4947 7660-7665 JJ denotes NF-κB
T4948 7666-7674 NN denotes activity
T4949 7675-7676 -LRB- denotes (
T4950 7676-7682 NN denotes figure
T4951 7683-7685 CD denotes 2e
T4952 7685-7686 -RRB- denotes )
T4953 7686-7687 : denotes ;
T4954 7688-7697 RB denotes therefore
T4955 7697-7698 , denotes ,
T4956 7699-7701 PRP denotes we
T4957 7702-7709 VBD denotes exposed
T4958 7710-7717 NNS denotes T-cells
T4959 7718-7720 TO denotes to
T4960 7721-7722 DT denotes a
T4961 7723-7726 NNP denotes PKC
T4962 7727-7736 NN denotes inhibitor
T4963 7737-7745 RB denotes together
T4964 7746-7750 IN denotes with
T4965 7751-7754 NNP denotes PMA
T4966 7755-7757 TO denotes to
T4967 7758-7767 VB denotes determine
T4968 7768-7771 PRP$ denotes its
T4969 7772-7778 NN denotes effect
T4970 7779-7781 IN denotes on
T4971 7782-7790 NN denotes cytokine
T4972 7791-7801 NN denotes expression
T4973 7801-7802 . denotes .
T4974 7803-7813 NNP denotes Inhibition
T4975 7814-7816 IN denotes of
T4976 7817-7820 NNP denotes PKC
T4977 7821-7828 VBD denotes reduced
T4978 7829-7834 CD denotes CXCL8
T4979 7835-7842 NN denotes release
T4980 7843-7847 IN denotes from
T4981 7848-7849 CD denotes 7
T4982 7850-7855 NN denotes ng/ml
T4983 7856-7858 TO denotes to
T4984 7859-7860 CD denotes 3
T4985 7861-7866 NN denotes ng/ml
T4986 7867-7872 IN denotes while
T4987 7873-7875 PRP denotes it
T4988 7876-7879 VBD denotes had
T4989 7880-7881 DT denotes a
T4990 7882-7888 JJ denotes modest
T4991 7889-7895 NN denotes effect
T4992 7896-7898 IN denotes on
T4993 7899-7903 NN denotes IL-6
T4994 7904-7907 CC denotes and
T4995 7908-7911 NNP denotes TNF
T4996 7912-7913 -LRB- denotes (
T5041 8170-8171 , denotes ,
T5042 8172-8179 VBG denotes leading
T5043 8180-8182 TO denotes to
T5044 8183-8191 JJ denotes cellular
T5045 8192-8201 NN denotes apoptosis
T5046 8202-8203 NNP denotes [
T5047 8203-8205 CD denotes 26
T5048 8205-8206 NNP denotes ]
T5049 8206-8207 . denotes .
T5050 8208-8218 NNP denotes Inhibition
T5051 8219-8221 IN denotes of
T5052 8222-8225 DT denotes the
T5053 8226-8229 NNP denotes JNK
T5054 8230-8238 NNS denotes pathways
T5055 8239-8247 VBD denotes resulted
T5056 8248-8250 IN denotes in
T5057 8251-8252 DT denotes a
T5058 8253-8268 NN denotes down-regulation
T5059 8269-8271 IN denotes of
T5060 8272-8276 DT denotes both
T5061 8277-8282 CD denotes CXCL8
T5062 8283-8286 CC denotes and
T5063 8287-8291 NNP denotes IL-6
T5064 8291-8292 , denotes ,
T5065 8293-8298 IN denotes while
T5066 8299-8301 DT denotes no
T5067 8302-8307 JJ denotes clear
T5068 8308-8314 NN denotes effect
T5069 8315-8318 VBD denotes was
T5070 8319-8327 VBN denotes observed
T5071 8328-8330 IN denotes on
T5072 8331-8334 NNP denotes TNF
T5073 8335-8345 NN denotes expression
T5074 8346-8347 -LRB- denotes (
T5075 8347-8353 NN denotes figure
T5076 8354-8358 JJ denotes 6a-c
T5077 8358-8359 -RRB- denotes )
T5078 8359-8360 . denotes .
T5079 8361-8369 NN denotes Analysis
T5080 8370-8372 IN denotes of
T5081 8373-8377 NNP denotes mRNA
T5082 8378-8384 NNS denotes levels
T5083 8385-8390 VBG denotes using
T5084 8391-8398 NNP denotes RT-qPCR
T5085 8399-8400 -LRB- denotes (
T5086 8400-8405 NN denotes table
T5087 8406-8407 CD denotes 2
T5088 8407-8408 -RRB- denotes )
T5089 8409-8415 VBD denotes showed
T5090 8416-8420 IN denotes that
T5091 8421-8424 NNP denotes PMA
T5092 8425-8432 VBD denotes induced
T5093 8433-8437 DT denotes both
T5094 8438-8442 JJ denotes il-6
T5095 8443-8446 CC denotes and
T5096 8447-8452 JJ denotes cxcl8
T5097 8453-8457 NNP denotes mRNA
T5098 8458-8459 -LRB- denotes (
T5099 8459-8467 JJ denotes 5.1-fold
T5100 8468-8471 CC denotes and
T5101 8472-8477 CD denotes 111.8
T5102 8478-8482 VBP denotes fold
T5103 8483-8495 RB denotes respectively
T5104 8495-8496 -RRB- denotes )
T5105 8496-8497 . denotes .
T5106 8498-8506 NN denotes Addition
T5107 8507-8509 IN denotes of
T5108 8510-8513 DT denotes the
T5109 8514-8519 JJ denotes NF-κB
T5110 8520-8529 NN denotes inhibitor
T5111 8530-8533 NNP denotes NAI
T5112 8534-8537 CC denotes and
T5113 8538-8541 DT denotes the
T5114 8542-8545 NNP denotes JNK
T5115 8546-8555 NN denotes inhibitor
T5116 8556-8563 VBD denotes reduced
T5117 8564-8567 DT denotes the
T5118 8568-8572 JJ denotes il-6
T5119 8573-8583 NN denotes expression
T5120 8584-8589 IN denotes below
T5121 8590-8595 JJ denotes basal
T5122 8596-8602 NNS denotes levels
T5123 8602-8603 . denotes .
T5124 8604-8606 IN denotes In
T5125 8607-8615 NN denotes contrast
T5126 8615-8616 , denotes ,
T5127 8617-8622 IN denotes while
T5128 8623-8626 DT denotes the
T5129 8627-8632 JJ denotes cxcl8
T5130 8633-8639 NNS denotes levels
T5131 8640-8644 VBD denotes were
T5132 8645-8655 VBN denotes suppressed
T5133 8656-8658 IN denotes by
T5134 8659-8662 DT denotes the
T5135 8663-8667 JJ denotes same
T5136 8668-8678 NNS denotes treatments
T5137 8679-8682 DT denotes the
T5138 8683-8689 NNS denotes levels
T5139 8690-8698 VBD denotes remained
T5140 8699-8707 JJ denotes elevated
T5141 8708-8713 IN denotes above
T5142 8714-8719 JJ denotes basal
T5143 8720-8725 NN denotes level
T5144 8725-8726 . denotes .
T6000 9634-9639 JJ denotes NF-κB
T6001 9640-9650 NN denotes inhibition
T6002 9651-9654 JJ denotes due
T6003 9655-9657 TO denotes to
T6004 9658-9671 JJ denotes PKC-dependent
T6005 9672-9677 JJ denotes Bcl10
T6006 9678-9689 NN denotes degradation
T6007 9690-9697 JJ denotes Western
T6008 9698-9702 NN denotes blot
T6009 9703-9711 NN denotes analysis
T6010 9712-9720 VBD denotes revealed
T6011 9721-9723 DT denotes an
T6012 9724-9737 NN denotes up-regulation
T6013 9738-9740 IN denotes of
T6014 9741-9759 NN denotes phosphorylated-PKC
T6015 9760-9765 IN denotes after
T6016 9766-9768 CD denotes 24
T6017 9769-9770 NN denotes h
T6018 9771-9780 NN denotes treatment
T6019 9781-9783 IN denotes of
T6020 9784-9790 NNP denotes Jurkat
T6021 9791-9798 NNS denotes T-cells
T6022 9799-9803 IN denotes with
T6023 9804-9807 NNP denotes PMA
T6024 9808-9810 CC denotes or
T6025 9811-9813 NNP denotes HK
T6026 9814-9816 NNP denotes E.
T6027 9817-9821 NNS denotes coli
T6028 9822-9823 -LRB- denotes (
T6029 9823-9829 NN denotes figure
T6030 9830-9832 NN denotes 7a
T6031 9832-9833 -RRB- denotes )
T6032 9833-9834 , denotes ,
T6033 9835-9840 IN denotes while
T6034 9841-9845 NNP denotes IκBβ
T6035 9846-9852 NNS denotes levels
T6036 9853-9861 VBD denotes remained
T6037 9862-9872 JJ denotes unaffected
T6038 9873-9874 -LRB- denotes (
T6039 9874-9880 NN denotes figure
T6040 9881-9883 NN denotes 7b
T6041 9883-9884 -RRB- denotes )
T6042 9884-9885 . denotes .
T6043 9886-9891 NNP denotes Bcl10
T6044 9892-9894 VBZ denotes is
T6045 9895-9896 DT denotes a
T6046 9897-9907 JJ denotes signalling
T6047 9908-9915 NN denotes protein
T6048 9916-9920 WDT denotes that
T6049 9921-9925 VBZ denotes acts
T6050 9926-9934 RB denotes upstream
T6051 9935-9937 IN denotes of
T6052 9938-9943 NN denotes NF-κB
T6053 9944-9946 IN denotes in
T6054 9947-9954 NN denotes concert
T6055 9955-9959 IN denotes with
T6056 9960-9966 NNP denotes CARMA1
T6057 9967-9970 CC denotes and
T6058 9971-9976 NNP denotes MALT1
T6059 9977-9980 CC denotes and
T6060 9981-9984 VBZ denotes has
T6061 9985-9989 VBN denotes been
T6062 9990-9999 VBN denotes suggested
T6063 10000-10002 TO denotes to
T6064 10003-10011 RB denotes directly
T6065 10012-10020 VB denotes regulate
T6066 10021-10026 JJ denotes NF-κB
T6067 10027-10035 NN denotes activity
T6068 10036-10038 IN denotes in
T6069 10039-10046 NNS denotes T-cells
T6070 10047-10048 NNP denotes [
T6071 10048-10050 CD denotes 27
T6072 10050-10051 NNP denotes ]
T6073 10051-10052 . denotes .
T6074 10053-10062 RB denotes Therefore
T6075 10062-10063 , denotes ,
T6076 10064-10069 JJ denotes Bcl10
T6077 10070-10080 NN denotes activation
T6078 10081-10084 VBD denotes was
T6079 10085-10094 VBN denotes evaluated
T6080 10095-10097 IN denotes in
T6081 10098-10102 DT denotes both
T6082 10103-10110 NN denotes control
T6083 10111-10114 CC denotes and
T6084 10115-10118 NNP denotes PMA
T6085 10119-10129 VBD denotes stimulated
T6086 10130-10135 NNS denotes cells
T6087 10136-10141 IN denotes after
T6088 10142-10144 CD denotes 10
T6089 10145-10148 NN denotes min
T6090 10148-10149 , denotes ,
T6091 10150-10151 CD denotes 1
T6092 10152-10153 NN denotes h
T6093 10153-10154 , denotes ,
T6094 10155-10156 CD denotes 6
T6095 10157-10158 NN denotes h
T6096 10158-10159 , denotes ,
T6097 10160-10163 CC denotes and
T6098 10164-10166 CD denotes 24
T6099 10167-10168 NN denotes h
T6100 10169-10174 VBG denotes using
T6101 10175-10182 JJ denotes western
T6102 10183-10187 NN denotes blot
T6103 10188-10196 NN denotes analysis
T6104 10196-10197 . denotes .
T6105 10198-10201 DT denotes The
T6106 10202-10207 JJ denotes Bcl10
T6107 10208-10214 NNS denotes levels
T6108 10215-10224 VBD denotes decreased
T6109 10225-10234 VBG denotes following
T6110 10235-10244 NN denotes treatment
T6111 10245-10249 IN denotes with
T6112 10250-10253 NNP denotes PMA
T6113 10253-10254 , denotes ,
T6114 10255-10260 IN denotes while
T6115 10261-10263 IN denotes in
T6116 10264-10271 NN denotes control
T6117 10272-10277 NNS denotes cells
T6118 10277-10278 , denotes ,
T6119 10279-10284 JJ denotes Bcl10
T6120 10285-10293 VBD denotes returned
T6121 10294-10296 TO denotes to
T6122 10297-10303 JJR denotes higher
T6123 10304-10310 NNS denotes levels
T6124 10311-10313 IN denotes by
T6125 10314-10316 CD denotes 24
T6126 10317-10318 NN denotes h
T6127 10319-10320 -LRB- denotes (
T6128 10320-10326 NN denotes figure
T6129 10327-10329 NN denotes 7c
T6130 10329-10330 -RRB- denotes )
T6131 10330-10331 . denotes .
T6132 10332-10336 DT denotes This
T6133 10337-10345 VBZ denotes suggests
T6134 10346-10350 IN denotes that
T6135 10351-10356 NNP denotes Bcl10
T6136 10357-10359 VBZ denotes is
T6137 10360-10368 VBN denotes involved
T6138 10369-10371 IN denotes in
T6139 10372-10375 DT denotes the
T6140 10376-10379 NNP denotes PMA
T6141 10380-10389 JJ denotes dependent
T6142 10390-10400 NN denotes inhibition
T6143 10401-10403 IN denotes of
T6144 10404-10409 JJ denotes NF-κB
T6145 10410-10420 NN denotes activation
T6146 10420-10421 . denotes .
T15027 1229-1233 CD denotes AP-1
T15028 1234-1244 NN denotes activation
T15029 1245-1254 VBG denotes following
T15030 1255-1264 JJ denotes long-term
T15031 1265-1273 NN denotes exposure
T15032 1274-1276 IN denotes of
T15033 1277-1283 NNP denotes Jurkat
T15034 1284-1291 NNS denotes T-cells
T15035 1292-1294 TO denotes to
T15036 1295-1298 NNP denotes PMA
T15037 1298-1299 . denotes .
T15038 1300-1306 NNP denotes Jurkat
T15039 1307-1314 NNS denotes T-cells
T15040 1315-1319 VBD denotes were
T15041 1320-1331 VBN denotes transfected
T15042 1332-1336 IN denotes with
T15043 1337-1347 NN denotes luciferase
T15044 1348-1356 NN denotes reporter
T15045 1357-1365 NNS denotes plasmids
T15046 1366-1376 VBG denotes containing
T15047 1377-1380 DT denotes the
T15048 1381-1385 NNP denotes AP-1
T15049 1386-1398 NNS denotes cis-elements
T15050 1398-1399 . denotes .
T15051 1400-1401 -LRB- denotes (
T15052 1401-1402 NNP denotes A
T15053 1402-1403 -RRB- denotes )
T15054 1404-1418 JJ denotes Time-dependent
T15055 1419-1423 NN denotes AP-1
T15056 1424-1434 NN denotes activation
T15057 1435-1437 IN denotes in
T15058 1438-1446 NN denotes response
T15059 1447-1449 TO denotes to
T15060 1450-1453 NNP denotes PMA
T15061 1453-1454 . denotes .
T15062 1455-1456 -LRB- denotes (
T15063 1456-1457 NNP denotes B
T15064 1457-1458 -RRB- denotes )
T15065 1459-1461 NNP denotes HK
T15066 1462-1464 NNP denotes E.
T15067 1465-1469 NNS denotes coli
T15068 1470-1474 VBZ denotes does
T15069 1475-1478 RB denotes not
T15070 1479-1487 VB denotes activate
T15071 1488-1492 NN denotes AP-1
T15072 1492-1493 . denotes .
T15073 1494-1495 -LRB- denotes (
T15074 1495-1496 $ denotes C
T15075 1496-1497 -RRB- denotes )
T15076 1498-1512 JJ denotes Dose-dependent
T15077 1513-1523 NN denotes activation
T15078 1524-1526 IN denotes of
T15079 1527-1531 NN denotes AP-1
T15080 1532-1536 VBD denotes were
T15081 1537-1546 VBN denotes performed
T15082 1547-1552 VBG denotes using
T15083 1553-1556 NNP denotes PMA
T15084 1557-1562 RB denotes alone
T15085 1563-1564 -LRB- denotes (
T15086 1564-1568 NN denotes grey
T15087 1569-1573 NNS denotes bars
T15088 1573-1574 -RRB- denotes )
T15089 1575-1578 CC denotes and
T15090 1579-1581 IN denotes in
T15091 1582-1593 NN denotes combination
T15092 1594-1598 IN denotes with
T15093 1599-1606 NN denotes calcium
T15094 1607-1616 NN denotes ionophore
T15095 1617-1618 -LRB- denotes (
T15096 1618-1621 NNP denotes CaI
T15097 1622-1625 CD denotes 955
T15098 1626-1628 NNP denotes μM
T15099 1628-1629 , denotes ,
T15100 1630-1635 JJ denotes black
T15101 1636-1640 NNS denotes bars
T15102 1640-1641 -RRB- denotes )
T15103 1641-1642 . denotes .
T15104 1643-1644 -LRB- denotes (
T15105 1644-1645 NNP denotes D
T15106 1645-1646 -RRB- denotes )
T15107 1647-1650 SYM denotes TCR
T15108 1650-1651 : denotes -
T15109 1651-1652 SYM denotes /
T15110 1652-1653 : denotes -
T15111 1654-1663 NN denotes deficient
T15112 1664-1669 NNS denotes cells
T15113 1670-1679 VBD denotes responded
T15114 1680-1682 TO denotes to
T15115 1683-1686 NNP denotes PMA
T15116 1687-1688 -LRB- denotes (
T15117 1688-1691 CD denotes 162
T15118 1692-1694 NNP denotes nM
T15119 1694-1695 -RRB- denotes )
T15120 1696-1698 IN denotes by
T15121 1699-1712 JJ denotes up-regulating
T15122 1713-1717 NN denotes AP-1
T15123 1718-1726 NN denotes activity
T15124 1726-1727 . denotes .
T15125 1728-1739 NNP denotes Statistical
T15126 1740-1752 NN denotes significance
T15127 1753-1757 IN denotes from
T15128 1758-1761 DT denotes the
T15129 1762-1769 NN denotes control
T15130 1770-1773 VBD denotes was
T15131 1774-1784 VBN denotes determined
T15132 1785-1790 VBG denotes using
T15133 1791-1798 NN denotes Student
T15134 1798-1800 POS denotes 's
T15135 1801-1807 JJS denotes t-test
T15136 1807-1808 . denotes .
T15137 1809-1810 -LRB- denotes (
T15138 1810-1811 FW denotes n
T15139 1812-1813 SYM denotes =
T15140 1814-1815 LS denotes 4
T15141 1815-1816 -RRB- denotes )
T15142 1816-1817 . denotes .
T15143 1818-1826 NNP denotes Controls
T15144 1827-1831 VBD denotes were
T15145 1832-1843 RB denotes arbitrarily
T15146 1844-1847 VBN denotes set
T15147 1848-1850 TO denotes to
T15148 1851-1852 CD denotes 1
T15149 1852-1853 . denotes .
T15309 2645-2650 JJ denotes NF-κB
T15310 2651-2666 NN denotes down-regulation
T15311 2667-2669 IN denotes by
T15312 2670-2673 NNP denotes PMA
T15313 2674-2677 CC denotes and
T15314 2678-2691 JJ denotes up-regulation
T15315 2692-2694 IN denotes by
T15316 2695-2699 NN denotes heat
T15317 2700-2706 VBD denotes killed
T15318 2707-2709 NNP denotes E.
T15319 2710-2714 NNS denotes coli
T15320 2715-2721 NNP denotes MG1655
T15321 2722-2731 VBG denotes following
T15322 2732-2741 JJ denotes long-term
T15323 2742-2753 NN denotes stimulation
T15324 2753-2754 . denotes .
T15325 2755-2767 NNP denotes Transfection
T15326 2768-2770 IN denotes of
T15327 2771-2777 NNP denotes Jurkat
T15328 2778-2785 NNS denotes T-cells
T15329 2786-2789 VBD denotes was
T15330 2790-2799 VBN denotes performed
T15331 2800-2805 VBG denotes using
T15332 2806-2816 NN denotes luciferase
T15333 2817-2825 NN denotes reporter
T15334 2826-2834 NNS denotes plasmids
T15335 2835-2845 VBG denotes containing
T15336 2846-2851 JJ denotes NF-κB
T15337 2852-2864 NNS denotes cis-elements
T15338 2864-2865 . denotes .
T15339 2866-2867 -LRB- denotes (
T15340 2867-2868 NNP denotes A
T15341 2868-2869 -RRB- denotes )
T15342 2870-2884 JJ denotes Time-dependent
T15343 2885-2896 NN denotes stimulation
T15344 2897-2899 IN denotes of
T15345 2900-2906 NNP denotes Jurkat
T15346 2907-2914 NNS denotes T-cells
T15347 2915-2920 VBG denotes using
T15348 2921-2924 NNP denotes PMA
T15349 2924-2925 . denotes .
T15350 2926-2931 JJ denotes NF-κB
T15351 2932-2942 NN denotes activation
T15352 2943-2946 VBD denotes was
T15353 2947-2956 VBN denotes evaluated
T15354 2957-2962 VBG denotes using
T15355 2963-2965 NNP denotes HK
T15356 2966-2968 NNP denotes E.
T15357 2969-2973 NNS denotes coli
T15358 2974-2976 IN denotes in
T15359 2977-2978 DT denotes a
T15360 2979-2980 -LRB- denotes (
T15361 2980-2981 NNP denotes B
T15362 2981-2982 -RRB- denotes )
T15363 2983-2987 NN denotes dose
T15364 2987-2988 : denotes -
T15365 2989-2992 CC denotes and
T15366 2993-2994 -LRB- denotes (
T15367 2994-2995 NNP denotes C
T15368 2995-2996 -RRB- denotes )
T15369 2997-3011 JJ denotes time-dependant
T15370 3012-3018 NN denotes manner
T15371 3018-3019 . denotes .
T15372 3020-3027 NN denotes Calcium
T15373 3028-3037 NN denotes ionophore
T15374 3038-3047 VBD denotes increased
T15375 3048-3053 JJ denotes NF-κB
T15376 3054-3062 NN denotes activity
T15377 3063-3072 VBG denotes following
T15378 3073-3076 NNP denotes PMA
T15379 3077-3085 NN denotes exposure
T15380 3086-3087 -LRB- denotes (
T15381 3087-3088 NNP denotes E
T15382 3088-3089 -RRB- denotes )
T15383 3090-3093 CC denotes and
T15384 3094-3102 VBD denotes resulted
T15385 3103-3105 IN denotes in
T15386 3106-3107 DT denotes a
T15387 3108-3116 JJ denotes negative
T15388 3117-3127 NN denotes regulation
T15389 3128-3130 IN denotes in
T15390 3131-3139 NN denotes response
T15391 3140-3142 TO denotes to
T15392 3143-3145 NNP denotes HK
T15393 3146-3148 NNP denotes E.
T15394 3149-3153 NNS denotes coli
T15395 3154-3165 NN denotes stimulation
T15396 3166-3167 -LRB- denotes (
T15397 3167-3168 NNP denotes D
T15398 3168-3169 -RRB- denotes )
T15399 3169-3170 . denotes .
T15400 3171-3182 NNP denotes Statistical
T15401 3183-3195 NN denotes significance
T15402 3196-3200 IN denotes from
T15403 3201-3204 DT denotes the
T15404 3205-3212 NN denotes control
T15405 3213-3216 VBD denotes was
T15406 3217-3227 VBN denotes determined
T15407 3228-3233 VBG denotes using
T15408 3234-3241 NN denotes Student
T15409 3241-3243 POS denotes 's
T15410 3244-3250 JJS denotes t-test
T15411 3250-3251 . denotes .
T15412 3252-3253 -LRB- denotes (
T15413 3253-3254 FW denotes n
T15414 3255-3256 SYM denotes =
T15415 3257-3258 LS denotes 4
T15416 3258-3259 -RRB- denotes )
T15417 3259-3260 . denotes .
T15418 3261-3269 NNP denotes Controls
T15419 3270-3274 VBD denotes were
T15420 3275-3286 RB denotes arbitrarily
T15421 3287-3290 VBN denotes set
T15422 3291-3293 TO denotes to
T15423 3294-3295 CD denotes 1
T15424 3295-3296 . denotes .
T15600 4600-4605 CD denotes CXCL8
T15601 4605-4606 , denotes ,
T15602 4607-4611 NNP denotes IL-6
T15603 4612-4615 CC denotes and
T15604 4616-4619 NNP denotes TNF
T15605 4620-4630 NN denotes expression
T15606 4631-4640 VBG denotes following
T15607 4641-4650 JJ denotes long-term
T15608 4651-4662 NN denotes stimulation
T15609 4663-4667 IN denotes with
T15610 4668-4671 NNP denotes PMA
T15611 4671-4672 . denotes .
T15612 4673-4679 NNP denotes Jurkat
T15613 4680-4687 NNS denotes T-cells
T15614 4688-4692 VBD denotes were
T15615 4693-4699 RB denotes either
T15616 4700-4707 VBN denotes treated
T15617 4708-4712 IN denotes with
T15618 4713-4718 NNS denotes media
T15619 4719-4720 -LRB- denotes (
T15620 4720-4725 JJ denotes white
T15621 4726-4730 NNS denotes bars
T15622 4730-4731 -RRB- denotes )
T15623 4732-4734 CC denotes or
T15624 4735-4745 VBN denotes stimulated
T15625 4746-4750 IN denotes with
T15626 4751-4754 NNP denotes PMA
T15627 4755-4756 -LRB- denotes (
T15628 4756-4761 JJ denotes black
T15629 4762-4766 NNS denotes bars
T15630 4766-4767 -RRB- denotes )
T15631 4768-4771 CC denotes and
T15632 4772-4781 VBN denotes incubated
T15633 4782-4785 IN denotes for
T15634 4786-4787 CD denotes 1
T15635 4788-4789 NN denotes h
T15636 4789-4790 , denotes ,
T15637 4791-4792 CD denotes 2
T15638 4793-4794 NN denotes h
T15639 4794-4795 , denotes ,
T15640 4796-4797 CD denotes 6
T15641 4798-4799 NN denotes h
T15642 4800-4803 CC denotes and
T15643 4804-4806 CD denotes 24
T15644 4807-4809 NN denotes h.
T15645 4810-4814 VBN denotes Aged
T15646 4815-4820 NNS denotes media
T15647 4821-4824 VBD denotes was
T15648 4825-4830 VBN denotes added
T15649 4831-4840 VBG denotes following
T15650 4841-4845 DT denotes each
T15651 4846-4860 NN denotes centrifugation
T15652 4861-4865 NN denotes step
T15653 4866-4880 NN denotes representative
T15654 4881-4883 TO denotes to
T15655 4884-4887 DT denotes the
T15656 4888-4899 NN denotes stimulation
T15657 4900-4904 NN denotes time
T15658 4905-4906 -LRB- denotes (
T15659 4906-4909 VB denotes see
T15660 4910-4919 NNPS denotes Materials
T15661 4920-4923 CC denotes and
T15662 4924-4931 NNS denotes methods
T15663 4931-4932 -RRB- denotes )
T15664 4932-4933 . denotes .
T15665 4934-4942 NNP denotes Cytokine
T15666 4943-4949 NNS denotes levels
T15667 4950-4951 -LRB- denotes (
T15668 4951-4952 NNP denotes A
T15669 4952-4953 -RRB- denotes )
T15670 4954-4959 NNP denotes CXCL8
T15671 4959-4960 , denotes ,
T15672 4961-4962 -LRB- denotes (
T15673 4962-4963 NNP denotes B
T15674 4963-4964 -RRB- denotes )
T15675 4965-4969 NNP denotes IL-6
T15676 4970-4973 CC denotes and
T15677 4974-4975 -LRB- denotes (
T15678 4975-4976 NNP denotes C
T15679 4976-4977 -RRB- denotes )
T15680 4978-4981 NNP denotes TNF
T15681 4982-4986 VBD denotes were
T15682 4987-4995 VBN denotes detected
T15683 4996-4998 IN denotes by
T15684 4999-5004 NNP denotes ELISA
T15685 5004-5005 . denotes .
T15686 5006-5017 NNP denotes Statistical
T15687 5018-5030 NN denotes significance
T15688 5031-5035 IN denotes from
T15689 5036-5039 DT denotes the
T15690 5040-5047 NN denotes control
T15691 5048-5051 VBD denotes was
T15692 5052-5062 VBN denotes determined
T15693 5063-5068 VBG denotes using
T15694 5069-5076 NN denotes Student
T15695 5076-5078 POS denotes 's
T15696 5079-5085 JJS denotes t-test
T15697 5085-5086 . denotes .
T15698 5087-5088 -LRB- denotes (
T15699 5088-5089 FW denotes n
T15700 5090-5091 SYM denotes =
T15701 5092-5093 LS denotes 3
T15702 5093-5094 -RRB- denotes )
T15703 5094-5095 . denotes .
T15876 6306-6316 NNP denotes Inhibition
T15877 6317-6319 IN denotes of
T15878 6320-6325 JJ denotes NF-κB
T15879 6326-6334 NN denotes activity
T15880 6335-6337 IN denotes by
T15881 6338-6341 NNP denotes NAI
T15882 6341-6342 . denotes .
T15883 6343-6349 NNP denotes Jurkat
T15884 6350-6357 NNS denotes T-cells
T15885 6358-6362 VBD denotes were
T15886 6363-6374 VBN denotes transfected
T15887 6375-6379 IN denotes with
T15888 6380-6390 NN denotes luciferase
T15889 6391-6399 NN denotes reporter
T15890 6400-6408 NNS denotes plasmids
T15891 6409-6419 VBG denotes containing
T15892 6420-6426 CC denotes either
T15893 6427-6432 NNP denotes NF-κB
T15894 6433-6435 CC denotes or
T15895 6436-6440 NNP denotes AP-1
T15896 6441-6451 JJ denotes cis-acting
T15897 6452-6460 NNS denotes elements
T15898 6460-6461 . denotes .
T15899 6462-6465 DT denotes The
T15900 6466-6471 NNS denotes cells
T15901 6472-6476 VBD denotes were
T15902 6477-6486 VBN denotes incubated
T15903 6487-6491 IN denotes with
T15904 6492-6497 JJ denotes NF-κB
T15905 6498-6508 NN denotes activation
T15906 6509-6518 NN denotes inhibitor
T15907 6519-6520 -LRB- denotes (
T15908 6520-6523 NNP denotes NAI
T15909 6523-6524 -RRB- denotes )
T15910 6525-6528 IN denotes for
T15911 6529-6530 CD denotes 1
T15912 6531-6532 NN denotes h
T15913 6533-6541 VBN denotes followed
T15914 6542-6544 IN denotes by
T15915 6545-6556 NN denotes stimulation
T15916 6557-6561 IN denotes with
T15917 6562-6565 NNP denotes PMA
T15918 6566-6567 -LRB- denotes (
T15919 6567-6570 CD denotes 162
T15920 6571-6573 NNP denotes nM
T15921 6573-6574 , denotes ,
T15922 6575-6576 NNP denotes A
T15923 6577-6580 CC denotes and
T15924 6581-6582 NNP denotes C
T15925 6582-6583 -RRB- denotes )
T15926 6584-6586 CC denotes or
T15927 6587-6589 NNP denotes HK
T15928 6590-6592 NNP denotes E.
T15929 6593-6597 NNS denotes coli
T15930 6598-6599 -LRB- denotes (
T15931 6599-6600 CD denotes 5
T15932 6601-6602 CD denotes ×
T15933 6603-6606 CD denotes 107
T15934 6607-6613 NNP denotes CFU/ml
T15935 6613-6614 , denotes ,
T15936 6615-6616 NNP denotes B
T15937 6617-6620 CC denotes and
T15938 6621-6622 NNP denotes D
T15939 6622-6623 -RRB- denotes )
T15940 6624-6627 IN denotes for
T15941 6628-6630 CD denotes 24
T15942 6631-6633 NN denotes h.
T15943 6634-6635 -LRB- denotes (
T15944 6635-6636 DT denotes A
T15945 6636-6637 , denotes ,
T15946 6638-6639 NNP denotes B
T15947 6639-6640 -RRB- denotes )
T15948 6641-6646 NNP denotes NF-κB
T15949 6646-6647 , denotes ,
T15950 6648-6651 CC denotes but
T15951 6652-6655 RB denotes not
T15952 6656-6657 -LRB- denotes (
T15953 6657-6658 NNP denotes C
T15954 6658-6659 , denotes ,
T15955 6660-6661 NNP denotes D
T15956 6661-6662 -RRB- denotes )
T15957 6663-6667 NN denotes AP-1
T15958 6668-6671 VBD denotes was
T15959 6672-6681 VBN denotes inhibited
T15960 6681-6682 . denotes .
T15961 6683-6694 NNP denotes Statistical
T15962 6695-6707 NN denotes significance
T15963 6708-6712 IN denotes from
T15964 6713-6716 DT denotes the
T15965 6717-6725 JJ denotes positive
T15966 6726-6733 NN denotes control
T15967 6734-6735 -LRB- denotes (
T15968 6735-6741 NNP denotes PMA/HK
T15969 6742-6744 NNP denotes E.
T15970 6745-6749 NNS denotes coli
T15971 6749-6750 -RRB- denotes )
T15972 6751-6754 VBD denotes was
T15973 6755-6765 VBN denotes determined
T15974 6766-6771 VBG denotes using
T15975 6772-6779 NN denotes Student
T15976 6779-6781 POS denotes 's
T15977 6782-6788 JJS denotes t-test
T15978 6788-6789 . denotes .
T15979 6790-6791 -LRB- denotes (
T15980 6791-6792 FW denotes n
T15981 6793-6794 SYM denotes =
T15982 6795-6796 LS denotes 4
T15983 6796-6797 -RRB- denotes )
T15984 6797-6798 . denotes .
T15985 6799-6807 NNP denotes Controls
T15986 6808-6812 VBD denotes were
T15987 6813-6816 VBN denotes set
T15988 6817-6819 TO denotes to
T15989 6820-6821 CD denotes 1
T15990 6821-6822 . denotes .
T16168 6833-6844 NN denotes Involvement
T16169 6845-6847 IN denotes of
T16170 6848-6853 NN denotes NF-κB
T16171 6854-6856 IN denotes in
T16172 6857-6865 NN denotes cytokine
T16173 6866-6876 NN denotes regulation
T16174 6876-6877 . denotes .
T16175 6878-6896 JJ denotes Cytokine/chemokine
T16176 6897-6903 NNS denotes levels
T16177 6904-6908 VBD denotes were
T16178 6909-6919 VBN denotes determined
T16179 6920-6925 VBG denotes using
T16180 6926-6931 NNP denotes ELISA
T16181 6932-6941 VBG denotes following
T16182 6942-6952 NN denotes incubation
T16183 6953-6955 IN denotes of
T16184 6956-6962 NNP denotes Jurkat
T16185 6963-6970 NNS denotes T-cells
T16186 6971-6975 IN denotes with
T16187 6976-6979 NNP denotes NAI
T16188 6980-6981 -LRB- denotes (
T16189 6981-6982 CD denotes 1
T16190 6983-6984 NN denotes h
T16191 6984-6985 -RRB- denotes )
T16192 6986-6989 CC denotes and
T16193 6990-7001 NN denotes stimulation
T16194 7002-7003 -LRB- denotes (
T16195 7003-7005 CD denotes 24
T16196 7006-7007 NN denotes h
T16197 7007-7008 -RRB- denotes )
T16198 7008-7009 . denotes .
T16199 7010-7011 -LRB- denotes (
T16200 7011-7012 NNP denotes A
T16201 7012-7013 -RRB- denotes )
T16202 7014-7019 NNP denotes CXCL8
T16203 7020-7030 NN denotes expression
T16204 7031-7034 VBD denotes was
T16205 7035-7044 RB denotes partially
T16206 7045-7054 VBN denotes inhibited
T16207 7055-7064 VBG denotes following
T16208 7065-7068 NNP denotes PMA
T16209 7069-7080 NN denotes stimulation
T16210 7081-7082 -LRB- denotes (
T16211 7082-7086 NN denotes grey
T16212 7087-7091 NNS denotes bars
T16213 7091-7092 -RRB- denotes )
T16214 7092-7093 , denotes ,
T16215 7094-7101 IN denotes whereas
T16216 7102-7105 DT denotes the
T16217 7106-7112 NNS denotes levels
T16218 7113-7117 VBD denotes were
T16219 7118-7121 RB denotes not
T16220 7122-7129 VBN denotes altered
T16221 7130-7139 VBG denotes following
T16222 7140-7151 NN denotes stimulation
T16223 7152-7156 IN denotes with
T16224 7157-7159 NNP denotes HK
T16225 7160-7162 NNP denotes E.
T16226 7163-7167 NNS denotes coli
T16227 7168-7169 -LRB- denotes (
T16228 7169-7174 JJ denotes black
T16229 7175-7179 NNS denotes bars
T16230 7179-7180 -RRB- denotes )
T16231 7180-7181 , denotes ,
T16232 7182-7186 DT denotes this
T16233 7187-7196 VBZ denotes indicates
T16234 7197-7199 DT denotes an
T16235 7200-7209 NN denotes induction
T16236 7210-7216 RB denotes mainly
T16237 7217-7226 VBN denotes regulated
T16238 7227-7229 IN denotes by
T16239 7230-7234 NN denotes AP-1
T16240 7234-7235 . denotes .
T16241 7236-7237 -LRB- denotes (
T16242 7237-7238 NNP denotes B
T16243 7238-7239 -RRB- denotes )
T16244 7240-7243 NNP denotes TNF
T16245 7244-7254 NN denotes expression
T16246 7255-7258 VBD denotes was
T16247 7259-7262 RB denotes not
T16248 7263-7271 VBN denotes affected
T16249 7272-7274 IN denotes by
T16250 7275-7278 NNP denotes NAI
T16251 7278-7279 . denotes .
T16252 7280-7281 -LRB- denotes (
T16253 7281-7282 $ denotes C
T16254 7282-7283 -RRB- denotes )
T16255 7284-7288 NN denotes IL-6
T16256 7289-7296 NN denotes release
T16257 7297-7300 VBD denotes was
T16258 7301-7311 RB denotes completely
T16259 7312-7321 VBN denotes inhibited
T16260 7322-7324 IN denotes by
T16261 7325-7328 NNP denotes NAI
T16262 7329-7338 VBG denotes following
T16263 7339-7342 NNP denotes PMA
T16264 7343-7351 NN denotes exposure
T16265 7351-7352 , denotes ,
T16266 7353-7363 VBG denotes indicating
T16267 7364-7374 NN denotes regulation
T16268 7375-7382 IN denotes through
T16269 7383-7388 NNP denotes NF-κB
T16270 7389-7394 IN denotes since
T16271 7395-7399 NNP denotes IL-6
T16272 7400-7410 NN denotes expression
T16273 7411-7414 VBD denotes was
T16274 7415-7428 RB denotes significantly
T16275 7429-7438 VBN denotes increased
T16276 7439-7441 IN denotes in
T16277 7442-7450 NN denotes response
T16278 7451-7453 TO denotes to
T16279 7454-7456 NNP denotes HK
T16280 7457-7459 NNP denotes E.
T16281 7460-7464 NNS denotes coli
T16282 7465-7469 IN denotes than
T16283 7470-7473 NNP denotes PMA
T16284 7473-7474 . denotes .
T16285 7475-7486 NNP denotes Statistical
T16286 7487-7499 NN denotes significance
T16287 7500-7504 IN denotes from
T16288 7505-7508 DT denotes the
T16289 7509-7517 JJ denotes positive
T16290 7518-7525 NN denotes control
T16291 7526-7527 -LRB- denotes (
T16292 7527-7533 NNP denotes PMA/HK
T16293 7534-7536 NNP denotes E.
T16294 7537-7541 NNS denotes coli
T16295 7541-7542 -RRB- denotes )
T16296 7543-7546 VBD denotes was
T16297 7547-7557 VBN denotes determined
T16298 7558-7563 VBG denotes using
T16299 7564-7571 NN denotes Student
T16300 7571-7573 POS denotes 's
T16301 7574-7580 JJS denotes t-test
T16302 7580-7581 . denotes .
T16303 7582-7583 -LRB- denotes (
T16304 7583-7584 FW denotes n
T16305 7585-7586 SYM denotes =
T16306 7587-7588 LS denotes 3
T16307 7588-7589 -RRB- denotes )
T16308 7589-7590 . denotes .
T16439 8737-8748 NN denotes Involvement
T16440 8749-8751 IN denotes of
T16441 8752-8755 NNP denotes PKC
T16442 8756-8759 CC denotes and
T16443 8760-8763 NNP denotes JNK
T16444 8764-8766 IN denotes in
T16445 8767-8775 NN denotes cytokine
T16446 8776-8786 NN denotes expression
T16447 8786-8787 . denotes .
T16448 8788-8794 NNP denotes Jurkat
T16449 8795-8802 NNS denotes T-cells
T16450 8803-8807 VBD denotes were
T16451 8808-8817 VBN denotes incubated
T16452 8818-8822 IN denotes with
T16453 8823-8826 NNP denotes PKC
T16454 8826-8827 : denotes -
T16455 8828-8831 CC denotes and
T16456 8832-8835 NNP denotes JNK
T16457 8836-8846 NNS denotes inhibitors
T16458 8847-8850 IN denotes for
T16459 8851-8852 CD denotes 1
T16460 8853-8854 NN denotes h
T16461 8855-8863 VBN denotes followed
T16462 8864-8866 IN denotes by
T16463 8867-8878 NN denotes stimulation
T16464 8879-8883 IN denotes with
T16465 8884-8887 NNP denotes PMA
T16466 8888-8889 -LRB- denotes (
T16467 8889-8892 CD denotes 162
T16468 8893-8895 NNP denotes nM
T16469 8895-8896 -RRB- denotes )
T16470 8897-8900 IN denotes for
T16471 8901-8903 CD denotes 24
T16472 8904-8906 NN denotes h.
T16473 8907-8908 -LRB- denotes (
T16474 8908-8909 NNP denotes A
T16475 8909-8910 -RRB- denotes )
T16476 8911-8916 NNP denotes CXCL8
T16477 8917-8927 NN denotes expression
T16478 8928-8931 VBD denotes was
T16479 8932-8941 VBN denotes inhibited
T16480 8942-8944 IN denotes in
T16481 8945-8946 DT denotes a
T16482 8947-8961 JJ denotes dose-dependent
T16483 8962-8968 NN denotes manner
T16484 8969-8971 IN denotes by
T16485 8972-8976 DT denotes both
T16486 8977-8987 NNS denotes inhibitors
T16487 8987-8988 . denotes .
T16488 8989-8990 -LRB- denotes (
T16489 8990-8991 NNP denotes B
T16490 8991-8992 -RRB- denotes )
T16491 8993-8998 NNP denotes JNK-I
T16492 8999-9007 VBD denotes revealed
T16493 9008-9009 DT denotes a
T16494 9010-9018 JJR denotes stronger
T16495 9019-9029 JJ denotes inhibitory
T16496 9030-9036 NN denotes effect
T16497 9037-9039 IN denotes on
T16498 9040-9044 NN denotes IL-6
T16499 9045-9055 NN denotes expression
T16500 9056-9060 IN denotes than
T16501 9061-9064 DT denotes the
T16502 9065-9070 NNP denotes PKC-I
T16503 9070-9071 . denotes .
T16504 9072-9073 -LRB- denotes (
T16505 9073-9074 NNP denotes C
T16506 9074-9075 -RRB- denotes )
T16507 9076-9079 NNP denotes TNF
T16508 9080-9090 NN denotes expression
T16509 9091-9094 VBD denotes was
T16510 9095-9098 RB denotes not
T16511 9099-9107 VBN denotes affected
T16512 9108-9110 IN denotes by
T16513 9111-9117 DT denotes either
T16514 9118-9127 NN denotes inhibitor
T16515 9127-9128 . denotes .
T16516 9129-9140 NNP denotes Statistical
T16517 9141-9153 NN denotes significance
T16518 9154-9158 IN denotes from
T16519 9159-9162 DT denotes the
T16520 9163-9171 JJ denotes positive
T16521 9172-9179 NN denotes control
T16522 9180-9181 -LRB- denotes (
T16523 9181-9184 NNP denotes PMA
T16524 9184-9185 -RRB- denotes )
T16525 9186-9189 VBD denotes was
T16526 9190-9200 VBN denotes determined
T16527 9201-9206 VBG denotes using
T16528 9207-9214 NN denotes Student
T16529 9214-9216 POS denotes 's
T16530 9217-9223 JJS denotes t-test
T16531 9223-9224 . denotes .
T16532 9225-9226 -LRB- denotes (
T16533 9226-9227 FW denotes n
T16534 9228-9229 SYM denotes =
T16535 9230-9231 LS denotes 3
T16536 9231-9232 -RRB- denotes )
T16537 9232-9233 . denotes .
T16734 10432-10437 JJ denotes NF-κB
T16735 10438-10448 NN denotes inhibition
T16736 10449-10451 IN denotes by
T16737 10452-10455 NNP denotes PMA
T16738 10456-10466 VBD denotes correlated
T16739 10467-10469 TO denotes to
T16740 10470-10483 JJ denotes PKC-dependent
T16741 10484-10489 JJ denotes Bcl10
T16742 10490-10501 NN denotes degradation
T16743 10501-10502 . denotes .
T16744 10503-10509 NNS denotes Levels
T16745 10510-10512 IN denotes of
T16746 10513-10526 JJ denotes intracellular
T16747 10527-10534 NN denotes protein
T16748 10535-10539 VBD denotes were
T16749 10540-10548 VBN denotes assessed
T16750 10549-10558 VBG denotes following
T16751 10559-10561 CD denotes 24
T16752 10562-10563 NN denotes h
T16753 10564-10575 NN denotes stimulation
T16754 10576-10580 IN denotes with
T16755 10581-10584 NNP denotes PMA
T16756 10585-10586 -LRB- denotes (
T16757 10586-10589 CD denotes 162
T16758 10590-10592 NNP denotes nM
T16759 10592-10593 -RRB- denotes )
T16760 10594-10596 CC denotes or
T16761 10597-10599 NNP denotes HK
T16762 10600-10602 NNP denotes E.
T16763 10603-10607 NNS denotes coli
T16764 10608-10609 -LRB- denotes (
T16765 10609-10610 CD denotes 5
T16766 10611-10612 CD denotes ×
T16767 10613-10616 CD denotes 107
T16768 10617-10623 NNP denotes CFU/ml
T16769 10623-10624 -RRB- denotes )
T16770 10624-10625 . denotes .
T16771 10626-10627 -LRB- denotes (
T16772 10627-10628 NNP denotes A
T16773 10628-10629 -RRB- denotes )
T16774 10630-10641 NNP denotes Phospho-PKC
T16775 10642-10651 VBD denotes increased
T16776 10652-10654 IN denotes in
T16777 10655-10663 NN denotes response
T16778 10664-10666 TO denotes to
T16779 10667-10670 NNP denotes PMA
T16780 10671-10674 CC denotes and
T16781 10675-10677 NNP denotes HK
T16782 10678-10680 NNP denotes E.
T16783 10681-10685 NNS denotes coli
T16784 10686-10697 NN denotes stimulation
T16785 10697-10698 . denotes .
T16786 10699-10700 -LRB- denotes (
T16787 10700-10701 NNP denotes B
T16788 10701-10702 -RRB- denotes )
T16789 10703-10706 NNP denotes IκB
T16790 10707-10716 VBD denotes decreased
T16791 10717-10726 VBG denotes following
T16792 10727-10738 NN denotes stimulation
T16793 10739-10743 IN denotes with
T16794 10744-10746 NNP denotes HK
T16795 10747-10749 NNP denotes E.
T16796 10750-10754 NNS denotes coli
T16797 10755-10765 VBG denotes indicating
T16798 10766-10771 JJ denotes NF-κB
T16799 10772-10782 NN denotes activation
T16800 10782-10783 . denotes .
T16801 10784-10785 -LRB- denotes (
T16802 10785-10786 $ denotes C
T16803 10786-10787 -RRB- denotes )
T16804 10788-10793 JJ denotes Bcl10
T16805 10794-10804 NN denotes activation
T16806 10805-10808 VBD denotes was
T16807 10809-10818 VBN denotes inhibited
T16808 10819-10828 VBG denotes following
T16809 10829-10838 JJ denotes long-term
T16810 10839-10850 NN denotes stimulation
T16811 10851-10855 IN denotes with
T16812 10856-10859 NNP denotes PMA
T16813 10859-10860 , denotes ,
T16814 10861-10866 WDT denotes which
T16815 10867-10875 VBZ denotes explains
T16816 10876-10879 DT denotes the
T16817 10880-10890 JJ denotes inhibitory
T16818 10891-10897 NN denotes effect
T16819 10898-10900 IN denotes of
T16820 10901-10904 NNP denotes PMA
T16821 10905-10907 IN denotes on
T17023 5186-5188 CD denotes 24
T17024 5189-5191 NN denotes h.
T17047 9243-9249 NNP denotes Jurkat
T17048 9250-9257 NNS denotes T-cells
T17049 9258-9262 VBD denotes were
T17050 9263-9270 VBN denotes treated
T17051 9271-9275 IN denotes with
T17052 9276-9278 CD denotes 10
T17053 9279-9281 NNP denotes nM
T17054 9282-9285 NNP denotes NAI
T17055 9285-9286 , denotes ,
T17056 9287-9289 CD denotes 10
T17057 9290-9292 NNP denotes μM
T17058 9293-9298 NNP denotes JNK-I
T17059 9299-9303 CD denotes or10
T17060 9304-9306 NNP denotes nM
T17061 9307-9312 NNP denotes PKC-I
T17062 9313-9316 IN denotes for
T17063 9317-9318 CD denotes 2
T17064 9319-9320 NN denotes h
T17065 9321-9329 VBN denotes followed
T17066 9330-9332 IN denotes by
T17067 9333-9342 NN denotes induction
T17068 9343-9347 IN denotes with
T17069 9348-9351 CD denotes 162
T17070 9352-9354 NNP denotes nM
T17071 9355-9358 NNP denotes PMA
T17072 9359-9362 IN denotes for
T17073 9363-9365 CD denotes 24
T17074 9366-9368 NN denotes h.
T3156 606-614 VB denotes increase
T3172 688-694 VB denotes affect
T3352 2278-2288 NN denotes activation
T4138 4448-4458 VBN denotes correlated
T4781 5506-5511 NN denotes NF-κB
T4782 5512-5514 IN denotes in
T4997 7913-7919 NN denotes figure
T4998 7920-7924 JJ denotes 6a-c
T4999 7924-7925 -RRB- denotes )
T5000 7925-7926 . denotes .
T5001 7927-7931 DT denotes This
T5002 7932-7940 VBD denotes prompted
T5003 7941-7943 PRP denotes us
T5004 7944-7946 TO denotes to
T5005 7947-7951 VB denotes test
T5006 7952-7955 DT denotes the
T5007 7956-7962 NN denotes effect
T5008 7963-7965 IN denotes of
T5009 7966-7969 NNP denotes JNK
T5010 7970-7980 NN denotes inhibition
T5011 7981-7983 IN denotes on
T5012 7984-7995 JJ denotes PMA-induced
T5013 7996-8004 NN denotes cytokine
T5014 8005-8015 NN denotes expression
T5015 8015-8016 . denotes .
T5016 8017-8020 NNP denotes JNK
T5017 8021-8023 VBZ denotes is
T5018 8024-8032 VBN denotes involved
T5019 8033-8035 IN denotes in
T5020 8036-8039 DT denotes the
T5021 8040-8050 NN denotes regulation
T5022 8051-8053 IN denotes of
T5023 8054-8055 DT denotes a
T5024 8056-8065 NN denotes multitude
T5025 8066-8068 IN denotes of
T5026 8069-8078 JJ denotes different
T5027 8079-8092 NN denotes transcription
T5028 8093-8100 NNS denotes factors
T5029 8100-8101 , denotes ,
T5030 8102-8111 VBG denotes including
T5031 8112-8115 DT denotes the
T5032 8116-8131 NN denotes phosphorylation
T5033 8132-8135 CC denotes and
T5034 8136-8146 NN denotes activation
T5035 8147-8149 IN denotes of
T5036 8150-8155 NNP denotes c-Jun
T5037 8155-8156 , denotes ,
T5038 8157-8162 NNP denotes c-Fos
T5039 8163-8166 CC denotes and
T5040 8167-8170 NN denotes p53
T16822 10908-10913 NNP denotes NF-κB
T16823 10914-10924 NN denotes activation
T16824 10924-10925 . denotes .
T16825 10926-10933 NN denotes β-actin
T16826 10934-10937 VBD denotes was
T16827 10938-10942 VBN denotes used
T16828 10943-10945 IN denotes as
T16829 10946-10947 DT denotes a
T16830 10948-10955 VBG denotes loading
T16831 10956-10963 NN denotes control
T16832 10963-10964 . denotes .
T16833 10965-10966 -LRB- denotes (
T16834 10966-10967 FW denotes n
T16835 10968-10969 SYM denotes =
T16836 10970-10971 LS denotes 3
T16837 10971-10972 -RRB- denotes )
T16838 10972-10973 . denotes .
T17006 5105-5111 NNP denotes Jurkat
T17007 5112-5119 NNS denotes T-cells
T17008 5120-5124 VBD denotes were
T17009 5125-5135 VBN denotes stimulated
T17010 5136-5140 IN denotes with
T17011 5141-5144 CD denotes 162
T17012 5145-5147 NNP denotes nM
T17013 5148-5151 NNP denotes PMA
T17014 5152-5155 CC denotes and
T17015 5156-5157 CD denotes 5
T17016 5158-5159 CD denotes ×
T17017 5160-5163 CD denotes 107
T17018 5164-5170 NNP denotes CFU/ml
T17019 5171-5173 NNP denotes HK
T17020 5174-5176 NNP denotes E.
T17021 5177-5181 NNS denotes coli
T17022 5182-5185 IN denotes for
R2408 T3063 T3108 conj induction,pathways
R2415 T3070 T3072 det The,factors
R2416 T3071 T3072 compound transcription,factors
R2417 T3072 T3076 nsubj factors,play
R2418 T3073 T3076 nsubj NF-κB,play
R2419 T3074 T3073 cc and,NF-κB
R2420 T3075 T3073 conj AP-1,NF-κB
R2421 T3076 T3076 ROOT play,play
R2422 T3077 T3078 amod key,roles
R2423 T3078 T3076 dobj roles,play
R2424 T3079 T3076 prep in,play
R2425 T3080 T3081 det the,initiation
R2426 T3081 T3079 pobj initiation,in
R2427 T3082 T3081 prep of,initiation
R2428 T3083 T3085 det an,response
R2429 T3084 T3085 amod inflammatory,response
R2430 T3085 T3082 pobj response,of
R2431 T3086 T3076 prep by,play
R2432 T3087 T3086 pcomp inducing,by
R2433 T3088 T3089 det the,expression
R2434 T3089 T3087 dobj expression,inducing
R2435 T3090 T3089 cc and,expression
R2436 T3091 T3089 conj secretion,expression
R2437 T3092 T3089 prep of,expression
R2438 T3093 T3092 pobj chemokines,of
R2439 T3094 T3093 cc and,chemokines
R2440 T3095 T3093 conj cytokines,chemokines
R2441 T3096 T3097 nsubj that,attract
R2442 T3097 T3095 relcl attract,cytokines
R2443 T3098 T3097 cc and,attract
R2444 T3099 T3097 conj activate,attract
R2445 T3100 T3101 amod immune,cells
R2446 T3101 T3099 dobj cells,activate
R2447 T3102 T3076 punct .,play
R2448 T3103 T3117 advmod However,is
R2449 T3104 T3117 punct ",",is
R2450 T3105 T3108 det the,pathways
R2451 T3106 T3108 nmod signal,pathways
R2452 T3107 T3108 compound transduction,pathways
R2453 T3108 T3117 nsubj pathways,is
R2454 T3109 T3108 cc and,pathways
R2455 T3110 T3063 amod subsequent,induction
R2456 T3111 T3063 amod inflammatory,induction
R2457 T3112 T3063 compound cytokine,induction
R2458 T3113 T3063 prep by,induction
R2459 T3114 T3116 det these,factors
R2460 T3115 T3116 compound transcription,factors
R2461 T3116 T3113 pobj factors,by
R2462 T3117 T3120 auxpass is,elucidated
R2463 T3118 T3120 neg not,elucidated
R2464 T3119 T3120 advmod fully,elucidated
R2465 T3120 T3120 ROOT elucidated,elucidated
R2466 T3121 T3120 punct .,elucidated
R2467 T3122 T3124 det The,study
R2468 T3123 T3124 amod present,study
R2469 T3124 T3126 nsubjpass study,aimed
R2470 T3125 T3126 auxpass is,aimed
R2471 T3126 T3126 ROOT aimed,aimed
R2472 T3127 T3126 prep at,aimed
R2473 T3128 T3127 pcomp determining,at
R2474 T3129 T3130 det the,involvement
R2475 T3130 T3128 dobj involvement,determining
R2476 T3131 T3130 prep of,involvement
R2477 T3132 T3131 pobj AP-1,of
R2478 T3133 T3132 cc and,AP-1
R2479 T3134 T3132 conj NF-κB,AP-1
R2480 T3135 T3130 prep in,involvement
R2481 T3136 T3137 compound cytokine,induction
R2482 T3137 T3135 pobj induction,in
R2483 T3138 T3137 cc and,induction
R2484 T3139 T3137 conj regulation,induction
R2485 T3140 T3126 punct .,aimed
R2486 T3141 T3142 compound PMA,treatment
R2487 T3142 T3143 nsubj treatment,resulted
R2488 T3143 T3143 ROOT resulted,resulted
R2489 T3144 T3143 prep in,resulted
R2490 T3145 T3146 det an,up-regulation
R2491 T3146 T3144 pobj up-regulation,in
R2492 T3147 T3146 prep of,up-regulation
R2493 T3148 T3147 pobj AP-1,of
R2494 T3149 T3143 prep after,resulted
R2495 T3150 T3152 nummod 2,exposure
R2496 T3151 T3152 compound h,exposure
R2497 T3152 T3149 pobj exposure,after
R2498 T3153 T3143 cc and,resulted
R2499 T3154 T3143 conj continued,resulted
R2500 T3155 T3156 aux to,increase
R2501 T3156 T3154 xcomp increase,continued
R2502 T3157 T3156 prep throughout,increase
R2503 T3158 T3160 det the,period
R2504 T3159 T3160 compound analysis,period
R2505 T3160 T3157 pobj period,throughout
R2506 T3161 T3160 punct (,period
R2507 T3162 T3163 compound figure,1a
R2508 T3163 T3160 appos 1a,period
R2509 T3164 T3160 punct ),period
R2510 T3165 T3143 punct .,resulted
R2511 T3166 T3169 compound HK,treatment
R2512 T3167 T3169 compound E.,treatment
R2513 T3168 T3169 compound coli,treatment
R2514 T3169 T3172 nsubj treatment,affect
R2515 T3170 T3172 aux did,affect
R2516 T3171 T3172 neg not,affect
R2517 T3172 T3172 ROOT affect,affect
R2518 T3173 T3174 amod AP-1,activation
R2519 T3174 T3172 dobj activation,affect
R2520 T3175 T3174 prep in,activation
R2521 T3176 T3177 compound Jurkat,T-cells
R2522 T3177 T3175 pobj T-cells,in
R2523 T3178 T3179 punct (,figure
R2524 T3179 T3172 parataxis figure,affect
R2525 T3180 T3179 nummod 1b,figure
R2526 T3181 T3179 punct ),figure
R2527 T3182 T3172 punct .,affect
R2528 T3183 T3184 aux To,determine
R2529 T3184 T3192 advcl determine,exposed
R2530 T3185 T3186 det the,involvement
R2531 T3186 T3184 dobj involvement,determine
R2532 T3187 T3186 prep of,involvement
R2533 T3188 T3189 amod associated,pathways
R2534 T3189 T3187 pobj pathways,of
R2535 T3190 T3192 punct ",",exposed
R2536 T3191 T3192 nsubj we,exposed
R2537 T3192 T3192 ROOT exposed,exposed
R2538 T3193 T3192 dobj cells,exposed
R2539 T3194 T3192 prep to,exposed
R2540 T3195 T3197 amod Ca2,ionophore
R2541 T3196 T3197 compound +,ionophore
R2542 T3197 T3194 pobj ionophore,to
R2543 T3198 T3192 prep with,exposed
R2544 T3199 T3198 cc or,with
R2545 T3200 T3198 conj without,with
R2546 T3201 T3200 pobj PMA,without
R2547 T3202 T3192 cc and,exposed
R2548 T3203 T3192 conj observed,exposed
R2549 T3204 T3206 det a,involvement
R2550 T3205 T3206 amod modest,involvement
R2551 T3206 T3203 dobj involvement,observed
R2552 T3207 T3206 prep of,involvement
R2553 T3208 T3209 compound Ca2,+
R2554 T3209 T3207 pobj +,of
R2555 T3210 T3209 prep in,+
R2556 T3211 T3212 compound PMA-dependent,AP-1
R2557 T3212 T3213 compound AP-1,activation
R2558 T3213 T3210 pobj activation,in
R2559 T3214 T3215 punct (,figure
R2560 T3215 T3209 appos figure,+
R2561 T3216 T3215 nummod 1c,figure
R2562 T3217 T3209 punct ),+
R2563 T3218 T3224 mark while,alter
R2564 T3219 T3220 compound Ca2,+
R2565 T3220 T3224 nsubj +,alter
R2566 T3221 T3220 advmod alone,+
R2567 T3222 T3224 aux did,alter
R2568 T3223 T3224 neg not,alter
R2569 T3224 T3206 advcl alter,involvement
R2570 T3225 T3226 amod AP-1,activity
R2571 T3226 T3224 dobj activity,alter
R2572 T3227 T3228 punct (,data
R2573 T3228 T3226 appos data,activity
R2574 T3229 T3230 neg not,shown
R2575 T3230 T3228 acl shown,data
R2576 T3231 T3228 punct ),data
R2577 T3232 T3192 punct .,exposed
R2578 T3233 T3237 advmod Furthermore,decreased
R2579 T3234 T3236 punct ",",activity
R2580 T3235 T3236 amod AP-1,activity
R2581 T3236 T3237 nsubj activity,decreased
R2582 T3237 T3237 ROOT decreased,decreased
R2583 T3238 T3237 prep in,decreased
R2584 T3239 T3243 det a,line
R2585 T3240 T3243 amod TCR-deficient,line
R2586 T3241 T3243 compound Jurkat,line
R2587 T3242 T3243 compound cell,line
R2588 T3243 T3238 pobj line,in
R2589 T3244 T3245 advmod when,exposed
R2590 T3245 T3237 advcl exposed,decreased
R2591 T3246 T3245 prep to,exposed
R2592 T3247 T3246 pobj PMA,to
R2593 T3248 T3237 prep compared,decreased
R2594 T3249 T3248 prep to,compared
R2595 T3250 T3253 det the,line
R2596 T3251 T3252 compound parent,cell
R2597 T3252 T3253 compound cell,line
R2598 T3253 T3249 pobj line,to
R2599 T3254 T3253 acl indicating,line
R2600 T3255 T3259 mark that,was
R2601 T3256 T3259 nsubj regulation,was
R2602 T3257 T3256 prep of,regulation
R2603 T3258 T3257 pobj AP-1,of
R2604 T3259 T3254 ccomp was,indicating
R2605 T3260 T3261 advmod only,partially
R2606 T3261 T3264 advmod partially,dependent
R2607 T3262 T3264 nsubj T-cell,dependent
R2608 T3263 T3264 npadvmod receptor,dependent
R2609 T3264 T3259 acomp dependent,was
R2610 T3265 T3266 punct (,figure
R2611 T3266 T3259 parataxis figure,was
R2612 T3267 T3266 nummod 1d,figure
R2613 T3268 T3266 punct ),figure
R2614 T3269 T3237 punct .,decreased
R2615 T3270 T3271 compound NF-κB,levels
R2616 T3271 T3272 nsubj levels,showed
R2617 T3272 T3272 ROOT showed,showed
R2618 T3273 T3276 det a,increase
R2619 T3274 T3281 prep to,exposure
R2620 T3275 T3276 amod transient,increase
R2621 T3276 T3272 dobj increase,showed
R2622 T3277 T3272 prep at,showed
R2623 T3278 T3279 nummod 1,min
R2624 T3279 T3277 pobj min,at
R2625 T3280 T3272 prep after,showed
R2626 T3281 T3280 pobj exposure,after
R2627 T3282 T3274 pobj PMA,to
R2628 T3283 T3285 punct (,2a
R2629 T3284 T3285 compound figure,2a
R2630 T3285 T3282 appos 2a,PMA
R2631 T3286 T3272 punct ),showed
R2632 T3287 T3272 punct .,showed
R2633 T3288 T3297 advmod However,began
R2634 T3289 T3297 punct ",",began
R2635 T3290 T3291 nummod 1,h
R2636 T3291 T3297 nsubj h,began
R2637 T3292 T3291 prep after,h
R2638 T3293 T3292 pobj exposure,after
R2639 T3294 T3296 det the,levels
R2640 T3295 T3296 compound NF-κB,levels
R2641 T3296 T3297 nsubj levels,began
R2642 T3297 T3297 ROOT began,began
R2643 T3298 T3299 aux to,drop
R2644 T3299 T3297 xcomp drop,began
R2645 T3300 T3299 xcomp reaching,drop
R2646 T3301 T3303 det the,levels
R2647 T3302 T3303 amod lowest,levels
R2648 T3303 T3300 dobj levels,reaching
R2649 T3304 T3303 prep by,levels
R2650 T3305 T3306 nummod 6,h
R2651 T3306 T3304 pobj h,by
R2652 T3307 T3300 punct ",",reaching
R2653 T3308 T3311 prep after,increased
R2654 T3309 T3308 pobj which,after
R2655 T3310 T3311 nsubj they,increased
R2656 T3311 T3297 advcl increased,began
R2657 T3312 T3311 advmod again,increased
R2658 T3313 T3311 prep by,increased
R2659 T3314 T3316 nummod 24,Exposure
R2660 T3315 T3316 compound h.,Exposure
R2661 T3316 T3313 pobj Exposure,by
R2662 T3317 T3316 prep of,Exposure
R2663 T3318 T3319 compound Jurkat,T-cells
R2664 T3319 T3317 pobj T-cells,of
R2665 T3320 T3311 prep to,increased
R2666 T3321 T3323 compound HK,coli
R2667 T3322 T3323 compound E.,coli
R2668 T3323 T3320 pobj coli,to
R2669 T3324 T3311 conj resulted,increased
R2670 T3325 T3324 prep in,resulted
R2671 T3326 T3329 det a,activation
R2672 T3327 T3329 amod dose-dependent,activation
R2673 T3328 T3329 compound NF-κB,activation
R2674 T3329 T3325 pobj activation,in
R2675 T3330 T3324 punct ",",resulted
R2676 T3331 T3324 prep with,resulted
R2677 T3332 T3334 det the,activity
R2678 T3333 T3334 amod highest,activity
R2679 T3334 T3331 pobj activity,with
R2680 T3335 T3334 acl observed,activity
R2681 T3336 T3335 prep at,observed
R2682 T3337 T3339 det a,concentration
R2683 T3338 T3339 amod relative,concentration
R2684 T3339 T3336 pobj concentration,at
R2685 T3340 T3339 prep of,concentration
R2686 T3341 T3344 nummod 5,CFU/ml
R2687 T3342 T3344 nummod ×,CFU/ml
R2688 T3343 T3344 nummod 107,CFU/ml
R2689 T3344 T3340 pobj CFU/ml,of
R2690 T3345 T3347 punct (,2b
R2691 T3346 T3347 compound figure,2b
R2692 T3347 T3344 appos 2b,CFU/ml
R2693 T3348 T3347 punct ),2b
R2694 T3349 T3297 punct .,began
R2695 T3350 T3352 det The,activation
R2696 T3351 T3352 amod time-dependent,activation
R2697 T3352 T3360 nsubjpass activation,assessed
R2698 T3353 T3352 prep of,activation
R2699 T3354 T3353 pobj NF-κB,of
R2700 T3355 T3352 prep by,activation
R2701 T3356 T3358 compound HK,coli
R2702 T3357 T3358 compound E.,coli
R2703 T3358 T3355 pobj coli,by
R2704 T3359 T3360 auxpass was,assessed
R2705 T3360 T3360 ROOT assessed,assessed
R2706 T3361 T3362 advmod further,using
R2707 T3362 T3360 advcl using,assessed
R2708 T3363 T3365 det the,concentration
R2709 T3364 T3365 amod optimal,concentration
R2710 T3365 T3362 dobj concentration,using
R2711 T3366 T3365 acl obtained,concentration
R2712 T3367 T3366 prep from,obtained
R2713 T3368 T3367 pobj figure,from
R2714 T3369 T3368 nummod 2b,figure
R2715 T3370 T3360 cc and,assessed
R2716 T3371 T3360 conj showed,assessed
R2717 T3372 T3376 mark that,increased
R2718 T3373 T3375 det the,activity
R2719 T3374 T3375 amod NF-κB,activity
R2720 T3375 T3376 nsubj activity,increased
R2721 T3376 T3371 ccomp increased,showed
R2722 T3377 T3376 prep after,increased
R2723 T3378 T3379 nummod 3,h
R2724 T3379 T3377 pobj h,after
R2725 T3380 T3379 prep of,h
R2726 T3381 T3380 pobj exposure,of
R2727 T3382 T3383 punct (,figure
R2728 T3383 T3381 appos figure,exposure
R2729 T3384 T3383 npadvmod 2c,figure
R2730 T3385 T3376 punct ),increased
R2731 T3386 T3360 punct .,assessed
R2732 T3387 T3393 advmod Furthermore,reversed
R2733 T3388 T3393 punct ",",reversed
R2734 T3389 T3392 amod increased,+
R2735 T3390 T3392 compound intracellular,+
R2736 T3391 T3392 compound Ca2,+
R2737 T3392 T3393 nsubj +,reversed
R2738 T3393 T3393 ROOT reversed,reversed
R2739 T3394 T3395 det the,PMA
R2740 T3395 T3396 nsubj PMA,dependent
R2741 T3396 T3398 amod dependent,inhibition
R2742 T3397 T3398 compound NF-κB,inhibition
R2743 T3398 T3393 dobj inhibition,reversed
R2744 T3399 T3400 punct (,figure
R2745 T3400 T3393 parataxis figure,reversed
R2746 T3401 T3400 nummod 2d,figure
R2747 T3402 T3400 punct ),figure
R2748 T3403 T3393 cc and,reversed
R2749 T3404 T3393 conj reduced,reversed
R2750 T3405 T3412 det the,activation
R2751 T3406 T3408 compound HK,coli
R2752 T3407 T3408 compound E.,coli
R2753 T3408 T3410 npadvmod coli,dependent
R2754 T3409 T3410 punct -,dependent
R2755 T3410 T3412 amod dependent,activation
R2756 T3411 T3412 amod NF-κB,activation
R2757 T3412 T3404 dobj activation,reduced
R2758 T3413 T3414 punct (,figure
R2759 T3414 T3404 npadvmod figure,reduced
R2760 T3415 T3414 nummod 2e,figure
R2761 T3416 T3414 punct ),figure
R2762 T3417 T3393 punct .,reversed
R3180 T3942 T3942 ROOT evaluated,evaluated
R3181 T3943 T3951 cc and,PMA
R3182 T3944 T3942 npadvmod Induction,evaluated
R3183 T3945 T3944 prep of,Induction
R3184 T3946 T3947 amod inflammatory,responses
R3185 T3947 T3945 pobj responses,of
R3186 T3948 T3949 det The,ability
R3187 T3949 T3942 nsubjpass ability,evaluated
R3188 T3950 T3949 prep of,ability
R3189 T3951 T3950 pobj PMA,of
R3190 T3952 T3954 compound HK,coli
R3191 T3953 T3954 compound E.,coli
R3192 T3954 T3956 nsubj coli,induce
R3193 T3955 T3956 aux to,induce
R3194 T3956 T3949 acl induce,ability
R3195 T3957 T3959 det an,response
R3196 T3958 T3959 amod inflammatory,response
R3197 T3959 T3956 dobj response,induce
R3198 T3960 T3959 prep in,response
R3199 T3961 T3962 compound Jurkat,T-cells
R3200 T3962 T3960 pobj T-cells,in
R3201 T3963 T3942 auxpass was,evaluated
R3202 T3964 T3942 advcl using,evaluated
R3203 T3965 T3968 det a,assay
R3204 T3966 T3968 amod multiplex,assay
R3205 T3967 T3968 compound cytokine,assay
R3206 T3968 T3964 dobj assay,using
R3207 T3969 T3942 prep following,evaluated
R3208 T3970 T3972 nummod 24,stimulation
R3209 T3971 T3972 compound h,stimulation
R3210 T3972 T3969 pobj stimulation,following
R3211 T3973 T3942 punct .,evaluated
R3212 T3974 T3976 det The,profile
R3213 T3975 T3976 compound cytokine,profile
R3214 T3976 T3977 nsubj profile,revealed
R3215 T3977 T3977 ROOT revealed,revealed
R3216 T3978 T3980 det an,induction
R3217 T3979 T3980 amod enhanced,induction
R3218 T3980 T3977 dobj induction,revealed
R3219 T3981 T3980 prep of,induction
R3220 T3982 T3984 det the,cytokines
R3221 T3983 T3984 amod pro-inflammatory,cytokines
R3222 T3984 T3985 compound cytokines,IL-2
R3223 T3985 T3981 pobj IL-2,of
R3224 T3986 T3985 punct ",",IL-2
R3225 T3987 T3985 conj IL-6,IL-2
R3226 T3988 T3987 punct ",",IL-6
R3227 T3989 T3987 conj TNF,IL-6
R3228 T3990 T3989 cc and,TNF
R3229 T3991 T3993 det the,CXCL8
R3230 T3992 T3993 compound chemokine,CXCL8
R3231 T3993 T3989 conj CXCL8,TNF
R3232 T3994 T3977 punct .,revealed
R3233 T3995 T3996 det The,levels
R3234 T3996 T4003 nsubjpass levels,unaffected
R3235 T3997 T3996 prep of,levels
R3236 T3998 T4001 det the,IL-10
R3237 T3999 T4001 amod anti-inflammatory,IL-10
R3238 T4000 T4001 compound cytokine,IL-10
R3239 T4001 T3997 pobj IL-10,of
R3240 T4002 T4003 auxpass were,unaffected
R3241 T4003 T4003 ROOT unaffected,unaffected
R3242 T4004 T4003 agent by,unaffected
R3243 T4005 T4004 pobj PMA,by
R3244 T4006 T4003 cc but,unaffected
R3245 T4007 T4009 auxpass were,decreased
R3246 T4008 T4009 advmod significantly,decreased
R3247 T4009 T4003 conj decreased,unaffected
R3248 T4010 T4009 prep by,decreased
R3249 T4011 T4013 compound HK,coli
R3250 T4012 T4013 compound E.,coli
R3251 T4013 T4010 pobj coli,by
R3252 T4014 T4015 punct (,Table
R3253 T4015 T4013 appos Table,coli
R3254 T4016 T4015 nummod 1,Table
R3255 T4017 T4013 punct ),coli
R3256 T4018 T4009 punct .,decreased
R3257 T4019 T4020 det These,results
R3258 T4020 T4021 nsubj results,confirmed
R3259 T4021 T4021 ROOT confirmed,confirmed
R3260 T4022 T4028 mark that,induced
R3261 T4023 T4028 nsubj PMA,induced
R3262 T4024 T4023 cc and,PMA
R3263 T4025 T4027 compound HK,coli
R3264 T4026 T4027 compound E.,coli
R3265 T4027 T4023 conj coli,PMA
R3266 T4028 T4021 ccomp induced,confirmed
R3267 T4029 T4031 det an,response
R3268 T4030 T4031 amod inflammatory,response
R3269 T4031 T4028 dobj response,induced
R3270 T4032 T4031 prep in,response
R3271 T4033 T4035 det the,T-cells
R3272 T4034 T4035 compound Jurkat,T-cells
R3273 T4035 T4032 pobj T-cells,in
R3274 T4036 T4021 punct .,confirmed
R3275 T4037 T4038 nsubj It,is
R3276 T4038 T4038 ROOT is,is
R3277 T4039 T4038 acomp interesting,is
R3278 T4040 T4041 aux to,note
R3279 T4041 T4038 xcomp note,is
R3280 T4042 T4044 mark that,was
R3281 T4043 T4044 nsubj PMA,was
R3282 T4044 T4041 ccomp was,note
R3283 T4045 T4047 advmod 120-fold,effective
R3284 T4046 T4047 advmod more,effective
R3285 T4047 T4044 acomp effective,was
R3286 T4048 T4047 prep at,effective
R3287 T4049 T4048 pcomp inducing,at
R3288 T4050 T4049 dobj CXCL8,inducing
R3289 T4051 T4049 prep than,inducing
R3290 T4052 T4054 compound HK,coli
R3291 T4053 T4054 compound E.,coli
R3292 T4054 T4051 pobj coli,than
R3293 T4055 T4038 punct .,is
R3294 T4056 T4057 amod PMA-dependent,induction
R3295 T4057 T4064 nsubj induction,suggests
R3296 T4058 T4057 prep of,induction
R3297 T4059 T4058 pobj AP-1,of
R3298 T4060 T4059 cc and,AP-1
R3299 T4061 T4059 conj down-regulation,AP-1
R3300 T4062 T4059 prep of,AP-1
R3301 T4063 T4062 pobj NF-κB,of
R3302 T4064 T4064 ROOT suggests,suggests
R3303 T4065 T4066 det an,involvement
R3304 T4066 T4064 dobj involvement,suggests
R3305 T4067 T4066 prep of,involvement
R3306 T4068 T4067 pobj AP-1,of
R3307 T4069 T4066 prep in,involvement
R3308 T4070 T4071 nummod CXCL8,regulation
R3309 T4071 T4069 pobj regulation,in
R3310 T4072 T4064 punct .,suggests
R3311 T4073 T4085 nsubj Determination,showed
R3312 T4074 T4073 prep of,Determination
R3313 T4075 T4077 det the,course
R3314 T4076 T4077 compound time,course
R3315 T4077 T4074 pobj course,of
R3316 T4078 T4077 prep of,course
R3317 T4079 T4080 compound cytokine,induction
R3318 T4080 T4078 pobj induction,of
R3319 T4081 T4073 prep in,Determination
R3320 T4082 T4081 pobj response,in
R3321 T4083 T4082 prep to,response
R3322 T4084 T4083 pobj PMA,to
R3323 T4085 T4085 ROOT showed,showed
R3324 T4086 T4090 mark that,released
R3325 T4087 T4090 nsubjpass CXCL8,released
R3326 T4088 T4090 auxpass was,released
R3327 T4089 T4090 advmod already,released
R3328 T4090 T4085 ccomp released,showed
R3329 T4091 T4090 prep between,released
R3330 T4092 T4093 amod 2-6,h
R3331 T4093 T4091 pobj h,between
R3332 T4094 T4090 punct ",",released
R3333 T4095 T4100 mark while,released
R3334 T4096 T4100 nsubjpass TNF,released
R3335 T4097 T4096 cc and,TNF
R3336 T4098 T4096 conj IL-6,TNF
R3337 T4099 T4100 auxpass were,released
R3338 T4100 T4090 advcl released,released
R3339 T4101 T4100 prep between,released
R3340 T4102 T4103 nummod 6-24,h
R3341 T4103 T4101 pobj h,between
R3342 T4104 T4105 punct (,figure
R3343 T4105 T4103 appos figure,h
R3344 T4106 T4105 nummod 3,figure
R3345 T4107 T4105 punct ),figure
R3346 T4108 T4085 punct .,showed
R3347 T4109 T4110 det These,results
R3348 T4110 T4111 nsubj results,indicated
R3349 T4111 T4111 ROOT indicated,indicated
R3350 T4112 T4117 mark that,regulated
R3351 T4113 T4114 det the,cytokines
R3352 T4114 T4117 nsubjpass cytokines,regulated
R3353 T4115 T4117 auxpass were,regulated
R3354 T4116 T4117 advmod differentially,regulated
R3355 T4117 T4111 ccomp regulated,indicated
R3356 T4118 T4117 cc and,regulated
R3357 T4119 T4124 mark that,associated
R3358 T4120 T4121 det the,release
R3359 T4121 T4124 nsubjpass release,associated
R3360 T4122 T4124 auxpass was,associated
R3361 T4123 T4124 neg not,associated
R3362 T4124 T4117 conj associated,regulated
R3363 T4125 T4124 prep with,associated
R3364 T4126 T4129 det the,induction
R3365 T4127 T4129 amod early,induction
R3366 T4128 T4129 compound transient,induction
R3367 T4129 T4125 pobj induction,with
R3368 T4130 T4129 prep of,induction
R3369 T4131 T4130 pobj NF-κB,of
R3370 T4132 T4111 punct .,indicated
R3371 T4133 T4135 det The,induction
R3372 T4134 T4135 amod temporal,induction
R3373 T4135 T4138 nsubj induction,correlated
R3374 T4136 T4135 prep of,induction
R3375 T4137 T4138 amod AP-1,correlated
R3376 T4138 T4138 ROOT correlated,correlated
R3377 T4139 T4138 prep to,correlated
R3378 T4140 T4142 det the,levels
R3379 T4141 T4142 compound CXCL8,levels
R3380 T4142 T4139 pobj levels,to
R3381 T4143 T4138 cc and,correlated
R3382 T4144 T4138 conj preceded,correlated
R3383 T4145 T4146 det the,TNF
R3384 T4146 T4144 dobj TNF,preceded
R3385 T4147 T4146 cc and,TNF
R3386 T4148 T4146 conj IL-6,TNF
R3387 T4149 T4146 conj release,TNF
R3388 T4150 T4138 punct .,correlated
R3389 T4151 T4152 nsubj This,suggests
R3390 T4152 T4152 ROOT suggests,suggests
R3391 T4153 T4154 det an,association
R3392 T4154 T4152 dobj association,suggests
R3393 T4155 T4154 prep between,association
R3394 T4156 T4160 amod CXCL8,signalling
R3395 T4157 T4160 nmod release,signalling
R3396 T4158 T4157 cc and,release
R3397 T4159 T4157 conj AP-1,release
R3398 T4160 T4155 pobj signalling,between
R3399 T4161 T4152 punct .,suggests
R3816 T4767 T4768 amod Cooperative,induction
R3817 T4768 T4787 nsubj induction,treated
R3818 T4769 T4768 prep of,induction
R3819 T4770 T4769 pobj cytokines,of
R3820 T4771 T4768 prep by,induction
R3821 T4772 T4771 pobj AP-1,by
R3822 T4773 T4772 cc and,AP-1
R3823 T4774 T4772 conj NF-κB,AP-1
R3824 T4775 T4777 aux To,characterize
R3825 T4776 T4777 advmod further,characterize
R3826 T4777 T4787 advcl characterize,treated
R3827 T4778 T4779 det the,involvement
R3828 T4779 T4777 dobj involvement,characterize
R3829 T4780 T4779 prep of,involvement
R3830 T4781 T4780 pobj NF-κB,of
R3831 T4782 T4779 prep in,involvement
R3832 T4783 T4784 compound cytokine,regulation
R3833 T4784 T4782 pobj regulation,in
R3834 T4785 T4787 punct ",",treated
R3835 T4786 T4787 nsubj we,treated
R3836 T4787 T4787 ROOT treated,treated
R3837 T4788 T4787 dobj cells,treated
R3838 T4789 T4787 prep with,treated
R3839 T4790 T4793 det an,inhibitor
R3840 T4791 T4793 amod NF-κB,inhibitor
R3841 T4792 T4793 compound activation,inhibitor
R3842 T4793 T4789 pobj inhibitor,with
R3843 T4794 T4793 punct (,inhibitor
R3844 T4795 T4793 appos NAI,inhibitor
R3845 T4796 T4793 punct ),inhibitor
R3846 T4797 T4787 punct .,treated
R3847 T4798 T4799 det The,results
R3848 T4799 T4800 nsubj results,showed
R3849 T4800 T4800 ROOT showed,showed
R3850 T4801 T4804 mark that,down-regulated
R3851 T4802 T4804 nsubj NAI,down-regulated
R3852 T4803 T4804 advmod selectively,down-regulated
R3854 T4805 T4806 amod NF-κB,activation
R3855 T4806 T4804 dobj activation,down-regulated
R3856 T4807 T4809 punct (,4a
R3857 T4808 T4809 nsubj figures,4a
R3858 T4809 T4806 appos 4a,activation
R3859 T4810 T4809 cc and,4a
R3860 T4811 T4809 conj 4b,4a
R3861 T4812 T4809 punct ),4a
R3862 T4813 T4804 cc and,down-regulated
R3863 T4814 T4816 aux did,alter
R3864 T4815 T4816 neg not,alter
R3865 T4816 T4804 conj alter,down-regulated
R3866 T4817 T4818 amod AP-1,activity
R3867 T4818 T4816 dobj activity,alter
R3868 T4819 T4821 punct (,4c
R3869 T4820 T4821 nsubj figures,4c
R3870 T4821 T4816 parataxis 4c,alter
R3871 T4822 T4821 cc and,4c
R3872 T4823 T4821 conj 4d,4c
R3873 T4824 T4821 punct ),4c
R3874 T4825 T4800 punct .,showed
R3875 T4826 T4832 nsubj Exposure,resulted
R3876 T4827 T4826 prep of,Exposure
R3877 T4828 T4829 compound Jurkat,T-cells
R3878 T4829 T4827 pobj T-cells,of
R3879 T4830 T4826 prep to,Exposure
R3880 T4831 T4830 pobj NAI,to
R3881 T4832 T4832 ROOT resulted,resulted
R3882 T4833 T4832 prep in,resulted
R3883 T4834 T4836 det a,reduction
R3884 T4835 T4836 amod modest,reduction
R3885 T4836 T4833 pobj reduction,in
R3886 T4837 T4836 prep of,reduction
R3887 T4838 T4837 pobj CXCL8,of
R3888 T4839 T4836 prep following,reduction
R3889 T4840 T4841 compound PMA,exposure
R3890 T4841 T4839 pobj exposure,following
R3891 T4842 T4832 punct ",",resulted
R3892 T4843 T4847 mark while,alter
R3893 T4844 T4847 nsubj it,alter
R3894 T4845 T4847 aux did,alter
R3895 T4846 T4847 neg not,alter
R3896 T4847 T4832 advcl alter,resulted
R3897 T4848 T4850 det the,release
R3898 T4849 T4850 compound CXCL8,release
R3899 T4850 T4847 dobj release,alter
R3900 T4851 T4850 acl following,release
R3901 T4852 T4855 nmod HK,exposure
R3902 T4853 T4855 compound E.,exposure
R3903 T4854 T4855 compound coli,exposure
R3904 T4855 T4851 pobj exposure,following
R3905 T4856 T4858 punct (,5a
R3906 T4857 T4858 compound figure,5a
R3907 T4858 T4855 appos 5a,exposure
R3908 T4859 T4858 punct ),5a
R3909 T4860 T4832 punct .,resulted
R3910 T4861 T4864 nsubj NAI,affect
R3911 T4862 T4864 aux did,affect
R3912 T4863 T4864 neg not,affect
R3913 T4864 T4864 ROOT affect,affect
R3914 T4865 T4866 compound TNF,expression
R3915 T4866 T4864 dobj expression,affect
R3916 T4867 T4869 punct (,5b
R3917 T4868 T4869 compound figure,5b
R3918 T4869 T4866 appos 5b,expression
R3919 T4870 T4864 punct ),affect
R3920 T4871 T4864 advcl indicating,affect
R3921 T4872 T4874 mark that,is
R3922 T4873 T4874 nsubj NF-κB,is
R3923 T4874 T4871 ccomp is,indicating
R3924 T4875 T4874 neg not,is
R3925 T4876 T4878 det the,regulator
R3926 T4877 T4878 amod main,regulator
R3927 T4878 T4874 attr regulator,is
R3928 T4879 T4878 prep of,regulator
R3929 T4880 T4879 pobj CXCL8,of
R3930 T4881 T4880 cc or,CXCL8
R3931 T4882 T4880 conj TNF,CXCL8
R3932 T4883 T4878 prep following,regulator
R3933 T4884 T4885 preconj either,PMA
R3934 T4885 T4883 pobj PMA,following
R3935 T4886 T4885 cc or,PMA
R3936 T4887 T4890 compound HK,exposure
R3937 T4888 T4889 compound E.,coli
R3938 T4889 T4890 compound coli,exposure
R3939 T4890 T4885 conj exposure,PMA
R3940 T4891 T4890 prep in,exposure
R3941 T4892 T4893 compound Jurkat,T-cells
R3942 T4893 T4891 pobj T-cells,in
R3943 T4894 T4864 punct .,affect
R3944 T4895 T4899 prep In,resulted
R3945 T4896 T4895 pobj contrast,In
R3946 T4897 T4899 punct ",",resulted
R3947 T4898 T4899 nsubj NAI,resulted
R3948 T4899 T4899 ROOT resulted,resulted
R3949 T4900 T4899 prep in,resulted
R3950 T4901 T4903 det a,inhibition
R3951 T4902 T4903 amod complete,inhibition
R3952 T4903 T4900 pobj inhibition,in
R3953 T4904 T4903 prep of,inhibition
R3954 T4905 T4904 pobj IL-6,of
R3955 T4906 T4899 prep following,resulted
R3956 T4907 T4908 compound PMA,exposure
R3957 T4908 T4906 pobj exposure,following
R3958 T4909 T4908 cc and,exposure
R3959 T4910 T4913 det a,inhibition
R3960 T4911 T4912 nummod 45,%
R3961 T4912 T4913 compound %,inhibition
R3962 T4913 T4908 conj inhibition,exposure
R3963 T4914 T4908 prep following,exposure
R3964 T4915 T4918 nmod HK,exposure
R3965 T4916 T4918 compound E.,exposure
R3966 T4917 T4918 compound coli,exposure
R3967 T4918 T4914 pobj exposure,following
R3968 T4919 T4921 punct (,5c
R3969 T4920 T4921 compound figure,5c
R3970 T4921 T4918 appos 5c,exposure
R3971 T4922 T4921 punct ),5c
R3972 T4923 T4899 punct ",",resulted
R3973 T4924 T4899 advcl suggesting,resulted
R3974 T4925 T4926 det an,involvement
R3975 T4926 T4924 dobj involvement,suggesting
R3976 T4927 T4926 prep of,involvement
R3977 T4928 T4927 pobj NF-κB,of
R3978 T4929 T4928 prep in,NF-κB
R3979 T4930 T4931 compound IL-6,regulation
R3980 T4931 T4929 pobj regulation,in
R3981 T4932 T4899 punct .,resulted
R3982 T4933 T4934 nummod Ca2,+
R3983 T4934 T4936 nsubjpass +,observed
R3984 T4935 T4936 auxpass was,observed
R3985 T4936 T4957 ccomp observed,exposed
R3986 T4937 T4938 aux to,increase
R3987 T4938 T4936 xcomp increase,observed
R3988 T4939 T4940 amod AP-1,activity
R3989 T4940 T4938 dobj activity,increase
R3990 T4941 T4942 punct (,figure
R3991 T4942 T4938 parataxis figure,increase
R3992 T4943 T4942 nummod 1c,figure
R3993 T4944 T4942 punct ),figure
R3994 T4945 T4938 cc and,increase
R3995 T4946 T4938 conj reduce,increase
R3996 T4947 T4948 amod NF-κB,activity
R3997 T4948 T4946 dobj activity,reduce
R3998 T4949 T4950 punct (,figure
R3999 T4950 T4957 ccomp figure,exposed
R4000 T4951 T4950 nummod 2e,figure
R4001 T4952 T4950 punct ),figure
R4002 T4953 T4957 punct ;,exposed
R4003 T4954 T4957 advmod therefore,exposed
R4004 T4955 T4957 punct ",",exposed
R4005 T4956 T4957 nsubj we,exposed
R4006 T4957 T4957 ROOT exposed,exposed
R4007 T4958 T4957 dobj T-cells,exposed
R4008 T4959 T4957 prep to,exposed
R4009 T4960 T4962 det a,inhibitor
R4010 T4961 T4962 compound PKC,inhibitor
R4011 T4962 T4959 pobj inhibitor,to
R4012 T4963 T4964 advmod together,with
R4013 T4964 T4957 prep with,exposed
R4014 T4965 T4964 pobj PMA,with
R4015 T4966 T4967 aux to,determine
R4016 T4967 T4957 advcl determine,exposed
R4017 T4968 T4969 poss its,effect
R4018 T4969 T4967 dobj effect,determine
R4019 T4970 T4969 prep on,effect
R4020 T4971 T4972 amod cytokine,expression
R4021 T4972 T4970 pobj expression,on
R4022 T4973 T4957 punct .,exposed
R4023 T4974 T4977 nsubj Inhibition,reduced
R4024 T4975 T4974 prep of,Inhibition
R4025 T4976 T4975 pobj PKC,of
R4026 T4977 T4977 ROOT reduced,reduced
R4027 T4978 T4979 nummod CXCL8,release
R4028 T4979 T4977 dobj release,reduced
R4029 T4980 T4977 prep from,reduced
R4030 T4981 T4982 nummod 7,ng/ml
R4031 T4982 T4980 pobj ng/ml,from
R4032 T4983 T4977 prep to,reduced
R4033 T4984 T4985 nummod 3,ng/ml
R4034 T4985 T4983 pobj ng/ml,to
R4035 T4986 T4988 mark while,had
R4036 T4987 T4988 nsubj it,had
R4037 T4988 T4977 advcl had,reduced
R4038 T4989 T4991 det a,effect
R4039 T4990 T4991 amod modest,effect
R4040 T4991 T4988 dobj effect,had
R4041 T4992 T4991 prep on,effect
R4042 T4993 T4992 pobj IL-6,on
R4043 T4994 T4993 cc and,IL-6
R4044 T4995 T4993 conj TNF,IL-6
R4045 T4996 T4997 punct (,figure
R4046 T4997 T4998 nsubj figure,6a-c
R4047 T4998 T4995 appos 6a-c,TNF
R4048 T4999 T4998 punct ),6a-c
R4049 T5000 T4977 punct .,reduced
R4050 T5001 T5002 nsubj This,prompted
R4051 T5002 T5002 ROOT prompted,prompted
R4052 T5003 T5002 dobj us,prompted
R4053 T5004 T5005 aux to,test
R4054 T5005 T5002 xcomp test,prompted
R4055 T5006 T5007 det the,effect
R4056 T5007 T5005 dobj effect,test
R4057 T5008 T5007 prep of,effect
R4058 T5009 T5010 compound JNK,inhibition
R4059 T5010 T5008 pobj inhibition,of
R4060 T5011 T5010 prep on,inhibition
R4061 T5012 T5014 amod PMA-induced,expression
R4062 T5013 T5014 compound cytokine,expression
R4063 T5014 T5011 pobj expression,on
R4064 T5015 T5002 punct .,prompted
R4065 T5016 T5018 nsubjpass JNK,involved
R4066 T5017 T5018 auxpass is,involved
R4067 T5018 T5018 ROOT involved,involved
R4068 T5019 T5018 prep in,involved
R4069 T5020 T5021 det the,regulation
R4070 T5021 T5019 pobj regulation,in
R4071 T5022 T5021 prep of,regulation
R4072 T5023 T5024 det a,multitude
R4073 T5024 T5022 pobj multitude,of
R4074 T5025 T5024 prep of,multitude
R4075 T5026 T5028 amod different,factors
R4076 T5027 T5028 compound transcription,factors
R4077 T5028 T5025 pobj factors,of
R4078 T5029 T5028 punct ",",factors
R4079 T5030 T5028 prep including,factors
R4080 T5031 T5032 det the,phosphorylation
R4081 T5032 T5030 pobj phosphorylation,including
R4082 T5033 T5032 cc and,phosphorylation
R4083 T5034 T5032 conj activation,phosphorylation
R4084 T5035 T5034 prep of,activation
R4085 T5036 T5035 pobj c-Jun,of
R4086 T5037 T5036 punct ",",c-Jun
R4087 T5038 T5036 conj c-Fos,c-Jun
R4088 T5039 T5038 cc and,c-Fos
R4089 T5040 T5038 conj p53,c-Fos
R4090 T5041 T5018 punct ",",involved
R4091 T5042 T5018 advcl leading,involved
R4092 T5043 T5042 prep to,leading
R4093 T5044 T5045 amod cellular,apoptosis
R4094 T5045 T5043 pobj apoptosis,to
R4095 T5046 T5043 pobj [,to
R4096 T5047 T5048 nummod 26,]
R4097 T5048 T5046 dobj ],[
R4098 T5049 T5018 punct .,involved
R4099 T5050 T5055 nsubj Inhibition,resulted
R4100 T5051 T5050 prep of,Inhibition
R4101 T5052 T5054 det the,pathways
R4102 T5053 T5054 compound JNK,pathways
R4103 T5054 T5051 pobj pathways,of
R4104 T5055 T5055 ROOT resulted,resulted
R4105 T5056 T5055 prep in,resulted
R4106 T5057 T5058 det a,down-regulation
R4107 T5058 T5056 pobj down-regulation,in
R4108 T5059 T5058 prep of,down-regulation
R4109 T5060 T5061 det both,CXCL8
R4110 T5061 T5059 pobj CXCL8,of
R4111 T5062 T5061 cc and,CXCL8
R4112 T5063 T5061 conj IL-6,CXCL8
R4113 T5064 T5055 punct ",",resulted
R4114 T5065 T5070 mark while,observed
R4115 T5066 T5068 det no,effect
R4116 T5067 T5068 amod clear,effect
R4117 T5068 T5070 nsubjpass effect,observed
R4118 T5069 T5070 auxpass was,observed
R4119 T5070 T5055 advcl observed,resulted
R4120 T5071 T5070 prep on,observed
R4121 T5072 T5073 compound TNF,expression
R4122 T5073 T5071 pobj expression,on
R4123 T5074 T5075 punct (,figure
R4124 T5075 T5073 appos figure,expression
R4125 T5076 T5075 amod 6a-c,figure
R4126 T5077 T5070 punct ),observed
R4127 T5078 T5055 punct .,resulted
R4128 T5079 T5089 nsubj Analysis,showed
R4129 T5080 T5079 prep of,Analysis
R4130 T5081 T5082 compound mRNA,levels
R4131 T5082 T5080 pobj levels,of
R4132 T5083 T5079 acl using,Analysis
R4133 T5084 T5083 dobj RT-qPCR,using
R4134 T5085 T5084 punct (,RT-qPCR
R4135 T5086 T5084 appos table,RT-qPCR
R4136 T5087 T5086 nummod 2,table
R4137 T5088 T5084 punct ),RT-qPCR
R4138 T5089 T5089 ROOT showed,showed
R4139 T5090 T5092 mark that,induced
R4140 T5091 T5092 nsubj PMA,induced
R4141 T5092 T5089 ccomp induced,showed
R4142 T5093 T5094 preconj both,il-6
R4143 T5094 T5092 dobj il-6,induced
R4144 T5095 T5094 cc and,il-6
R4145 T5096 T5094 conj cxcl8,il-6
R4146 T5097 T5094 appos mRNA,il-6
R4147 T5098 T5099 punct (,5.1-fold
R4148 T5099 T5097 appos 5.1-fold,mRNA
R4149 T5100 T5099 cc and,5.1-fold
R4150 T5101 T5102 nummod 111.8,fold
R4151 T5102 T5099 conj fold,5.1-fold
R4152 T5103 T5102 advmod respectively,fold
R4153 T5104 T5099 punct ),5.1-fold
R4154 T5105 T5089 punct .,showed
R4155 T5106 T5116 nsubj Addition,reduced
R4156 T5107 T5106 prep of,Addition
R4157 T5108 T5111 det the,NAI
R4158 T5109 T5111 amod NF-κB,NAI
R4159 T5110 T5111 compound inhibitor,NAI
R4160 T5111 T5107 pobj NAI,of
R4161 T5112 T5111 cc and,NAI
R4162 T5113 T5115 det the,inhibitor
R4163 T5114 T5115 compound JNK,inhibitor
R4164 T5115 T5111 conj inhibitor,NAI
R4165 T5116 T5116 ROOT reduced,reduced
R4166 T5117 T5119 det the,expression
R4167 T5118 T5119 amod il-6,expression
R4168 T5119 T5116 dobj expression,reduced
R4169 T5120 T5119 prep below,expression
R4170 T5121 T5122 amod basal,levels
R4171 T5122 T5120 pobj levels,below
R4172 T5123 T5116 punct .,reduced
R4173 T5124 T5139 prep In,remained
R4174 T5125 T5124 pobj contrast,In
R4175 T5126 T5139 punct ",",remained
R4176 T5127 T5132 mark while,suppressed
R4177 T5128 T5130 det the,levels
R4178 T5129 T5130 amod cxcl8,levels
R4179 T5130 T5132 nsubjpass levels,suppressed
R4180 T5131 T5132 auxpass were,suppressed
R4181 T5132 T5139 advcl suppressed,remained
R4182 T5133 T5132 agent by,suppressed
R4183 T5134 T5136 det the,treatments
R4184 T5135 T5136 amod same,treatments
R4185 T5136 T5133 pobj treatments,by
R4186 T5137 T5138 det the,levels
R4187 T5138 T5139 nsubj levels,remained
R4188 T5139 T5139 ROOT remained,remained
R4189 T5140 T5139 acomp elevated,remained
R4190 T5141 T5140 prep above,elevated
R4191 T5142 T5143 amod basal,level
R4192 T5143 T5141 pobj level,above
R4193 T5144 T5139 punct .,remained
R4818 T6000 T6001 amod NF-κB,inhibition
R4819 T6001 T6010 nsubj inhibition,revealed
R4820 T6002 T6001 amod due,inhibition
R4821 T6003 T6002 pcomp to,due
R4822 T6004 T6009 amod PKC-dependent,analysis
R4823 T6005 T6006 amod Bcl10,degradation
R4824 T6006 T6009 amod degradation,analysis
R4825 T6007 T6009 amod Western,analysis
R4826 T6008 T6009 compound blot,analysis
R4827 T6009 T6002 pobj analysis,due
R4828 T6010 T6010 ROOT revealed,revealed
R4829 T6011 T6012 det an,up-regulation
R4830 T6012 T6010 dobj up-regulation,revealed
R4831 T6013 T6012 prep of,up-regulation
R4832 T6014 T6013 pobj phosphorylated-PKC,of
R4833 T6015 T6012 prep after,up-regulation
R4834 T6016 T6018 nummod 24,treatment
R4835 T6017 T6018 compound h,treatment
R4836 T6018 T6015 pobj treatment,after
R4837 T6019 T6018 prep of,treatment
R4838 T6020 T6021 compound Jurkat,T-cells
R4839 T6021 T6019 pobj T-cells,of
R4840 T6022 T6018 prep with,treatment
R4841 T6023 T6027 nmod PMA,coli
R4842 T6024 T6023 cc or,PMA
R4843 T6025 T6027 compound HK,coli
R4844 T6026 T6027 compound E.,coli
R4845 T6027 T6022 pobj coli,with
R4846 T6028 T6030 punct (,7a
R4847 T6029 T6030 compound figure,7a
R4848 T6030 T6027 appos 7a,coli
R4849 T6031 T6012 punct ),up-regulation
R4850 T6032 T6010 punct ",",revealed
R4851 T6033 T6036 mark while,remained
R4852 T6034 T6035 compound IκBβ,levels
R4853 T6035 T6036 nsubj levels,remained
R4854 T6036 T6010 advcl remained,revealed
R4855 T6037 T6036 acomp unaffected,remained
R4856 T6038 T6040 punct (,7b
R4857 T6039 T6040 compound figure,7b
R4858 T6040 T6036 parataxis 7b,remained
R4859 T6041 T6040 punct ),7b
R4860 T6042 T6010 punct .,revealed
R4891 T6073 T6062 punct .,suggested
R4892 T6074 T6079 advmod Therefore,evaluated
R4893 T6075 T6079 punct ",",evaluated
R4894 T6076 T6077 amod Bcl10,activation
R4895 T6077 T6079 nsubjpass activation,evaluated
R4896 T6078 T6079 auxpass was,evaluated
R4897 T6079 T6079 ROOT evaluated,evaluated
R4898 T6080 T6079 prep in,evaluated
R4899 T6081 T6082 det both,control
R4900 T6082 T6080 pobj control,in
R4901 T6083 T6082 cc and,control
R4902 T6084 T6082 conj PMA,control
R4903 T6085 T6079 conj stimulated,evaluated
R4904 T6086 T6085 dobj cells,stimulated
R4905 T6087 T6085 prep after,stimulated
R4906 T6088 T6089 nummod 10,min
R4907 T6089 T6087 pobj min,after
R4908 T6090 T6089 punct ",",min
R4909 T6091 T6092 nummod 1,h
R4945 T6127 T6129 punct (,7c
R4946 T6128 T6129 compound figure,7c
R4947 T6129 T6126 appos 7c,h
R4948 T6130 T6129 punct ),7c
R4949 T6131 T6108 punct .,decreased
R4950 T6132 T6133 nsubj This,suggests
R4951 T6133 T6133 ROOT suggests,suggests
R4952 T6134 T6137 mark that,involved
R4953 T6135 T6137 nsubjpass Bcl10,involved
R4954 T6136 T6137 auxpass is,involved
R4955 T6137 T6133 ccomp involved,suggests
R4956 T6138 T6137 prep in,involved
R4957 T6139 T6142 det the,inhibition
R4958 T6140 T6142 nmod PMA,inhibition
R4959 T6141 T6142 amod dependent,inhibition
R4960 T6142 T6138 pobj inhibition,in
R4961 T6143 T6142 prep of,inhibition
R4962 T6144 T6145 amod NF-κB,activation
R4963 T6145 T6143 pobj activation,of
R4964 T6146 T6133 punct .,suggests
R12177 T15027 T15028 nummod AP-1,activation
R12178 T15028 T15028 ROOT activation,activation
R12179 T15029 T15028 acl following,activation
R12180 T15030 T15031 amod long-term,exposure
R12181 T15031 T15029 pobj exposure,following
R12182 T15032 T15031 prep of,exposure
R12183 T15033 T15034 compound Jurkat,T-cells
R12184 T15034 T15032 pobj T-cells,of
R12185 T15035 T15031 prep to,exposure
R12186 T15036 T15035 pobj PMA,to
R12187 T15037 T15028 punct .,activation
R12188 T15038 T15039 compound Jurkat,T-cells
R12189 T15039 T15041 nsubjpass T-cells,transfected
R12190 T15040 T15041 auxpass were,transfected
R12191 T15041 T15041 ROOT transfected,transfected
R12192 T15042 T15041 prep with,transfected
R12193 T15043 T15044 compound luciferase,reporter
R12194 T15044 T15045 compound reporter,plasmids
R12195 T15045 T15042 pobj plasmids,with
R12196 T15046 T15045 acl containing,plasmids
R12197 T15047 T15049 det the,cis-elements
R12198 T15048 T15049 compound AP-1,cis-elements
R12199 T15049 T15046 dobj cis-elements,containing
R12200 T15050 T15041 punct .,transfected
R12201 T15051 T15052 punct (,A
R12202 T15052 T15052 ROOT A,A
R12203 T15053 T15052 punct ),A
R12204 T15054 T15056 amod Time-dependent,activation
R12205 T15055 T15056 compound AP-1,activation
R12206 T15056 T15056 ROOT activation,activation
R12207 T15057 T15056 prep in,activation
R12208 T15058 T15057 pobj response,in
R12209 T15059 T15058 prep to,response
R12210 T15060 T15059 pobj PMA,to
R12211 T15061 T15056 punct .,activation
R12212 T15062 T15070 punct (,activate
R12213 T15063 T15067 nmod B,coli
R12214 T15064 T15067 punct ),coli
R12215 T15065 T15067 compound HK,coli
R12216 T15066 T15067 compound E.,coli
R12217 T15067 T15070 nsubj coli,activate
R12218 T15068 T15070 aux does,activate
R12219 T15069 T15070 neg not,activate
R12220 T15070 T15070 ROOT activate,activate
R12221 T15071 T15070 dobj AP-1,activate
R12222 T15072 T15070 punct .,activate
R12223 T15073 T15074 punct (,C
R12224 T15074 T15077 nmod C,activation
R12225 T15075 T15074 punct ),C
R12226 T15076 T15077 amod Dose-dependent,activation
R12227 T15077 T15081 nsubjpass activation,performed
R12228 T15078 T15077 prep of,activation
R12229 T15079 T15078 pobj AP-1,of
R12230 T15080 T15081 auxpass were,performed
R12231 T15081 T15081 ROOT performed,performed
R12232 T15082 T15081 advcl using,performed
R12233 T15083 T15082 dobj PMA,using
R12234 T15084 T15083 advmod alone,PMA
R12235 T15085 T15083 punct (,PMA
R12236 T15086 T15087 amod grey,bars
R12237 T15087 T15083 appos bars,PMA
R12238 T15088 T15083 punct ),PMA
R12239 T15089 T15081 cc and,performed
R12240 T15090 T15081 conj in,performed
R12241 T15091 T15090 pobj combination,in
R12242 T15092 T15091 prep with,combination
R12243 T15093 T15094 compound calcium,ionophore
R12244 T15094 T15092 pobj ionophore,with
R12245 T15095 T15094 punct (,ionophore
R12246 T15096 T15098 nmod CaI,μM
R12247 T15097 T15098 nummod 955,μM
R12248 T15098 T15094 appos μM,ionophore
R12249 T15099 T15101 punct ",",bars
R12250 T15100 T15101 amod black,bars
R12251 T15101 T15098 appos bars,μM
R12252 T15102 T15098 punct ),μM
R12253 T15103 T15081 punct .,performed
R12254 T15104 T15105 punct (,D
R12255 T15105 T15105 ROOT D,D
R12256 T15106 T15105 punct ),D
R12257 T15107 T15112 amod TCR,cells
R12258 T15108 T15111 punct -,deficient
R12259 T15109 T15111 punct /,deficient
R12260 T15110 T15111 punct -,deficient
R12261 T15111 T15112 amod deficient,cells
R12262 T15112 T15113 nsubj cells,responded
R12263 T15113 T15113 ROOT responded,responded
R12264 T15114 T15113 prep to,responded
R12265 T15115 T15114 pobj PMA,to
R12266 T15116 T15115 punct (,PMA
R12267 T15117 T15118 nummod 162,nM
R12268 T15118 T15115 appos nM,PMA
R12269 T15119 T15115 punct ),PMA
R12270 T15120 T15113 prep by,responded
R12271 T15121 T15123 amod up-regulating,activity
R12272 T15122 T15123 compound AP-1,activity
R12273 T15123 T15120 pobj activity,by
R12274 T15124 T15113 punct .,responded
R12275 T15125 T15126 compound Statistical,significance
R12276 T15126 T15131 nsubjpass significance,determined
R12277 T15127 T15126 prep from,significance
R12278 T15128 T15129 det the,control
R12279 T15129 T15127 pobj control,from
R12280 T15130 T15131 auxpass was,determined
R12281 T15131 T15131 ROOT determined,determined
R12282 T15132 T15131 advcl using,determined
R12283 T15133 T15135 poss Student,t-test
R12284 T15134 T15133 case 's,Student
R12285 T15135 T15132 dobj t-test,using
R12286 T15136 T15131 punct .,determined
R12287 T15137 T15140 punct (,4
R12288 T15138 T15140 advmod n,4
R12289 T15139 T15140 punct =,4
R12290 T15140 T15146 meta 4,set
R12291 T15141 T15140 punct ),4
R12292 T15142 T15140 punct .,4
R12293 T15143 T15146 nsubjpass Controls,set
R12294 T15144 T15146 auxpass were,set
R12295 T15145 T15146 advmod arbitrarily,set
R12296 T15146 T15146 ROOT set,set
R12297 T15147 T15146 prep to,set
R12298 T15148 T15147 pobj 1,to
R12299 T15149 T15146 punct .,set
R12420 T15309 T15310 amod NF-κB,down-regulation
R12421 T15310 T15317 nsubj down-regulation,killed
R12422 T15311 T15310 prep by,down-regulation
R12423 T15312 T15311 pobj PMA,by
R12424 T15313 T15312 cc and,PMA
R12425 T15314 T15312 conj up-regulation,PMA
R12426 T15315 T15314 agent by,up-regulation
R12427 T15316 T15315 pobj heat,by
R12428 T15317 T15317 ROOT killed,killed
R12429 T15318 T15320 compound E.,MG1655
R12430 T15319 T15320 compound coli,MG1655
R12431 T15320 T15317 dobj MG1655,killed
R12432 T15321 T15317 prep following,killed
R12433 T15322 T15323 amod long-term,stimulation
R12434 T15323 T15321 pobj stimulation,following
R12435 T15324 T15317 punct .,killed
R12436 T15325 T15330 nsubjpass Transfection,performed
R12437 T15326 T15325 prep of,Transfection
R12438 T15327 T15328 compound Jurkat,T-cells
R12439 T15328 T15326 pobj T-cells,of
R12440 T15329 T15330 auxpass was,performed
R12441 T15330 T15330 ROOT performed,performed
R12442 T15331 T15330 advcl using,performed
R12443 T15332 T15333 compound luciferase,reporter
R12444 T15333 T15334 compound reporter,plasmids
R12445 T15334 T15331 dobj plasmids,using
R12446 T15335 T15334 acl containing,plasmids
R12447 T15336 T15337 amod NF-κB,cis-elements
R12448 T15337 T15335 dobj cis-elements,containing
R12449 T15338 T15330 punct .,performed
R12450 T15339 T15340 punct (,A
R12451 T15340 T15340 ROOT A,A
R12452 T15341 T15340 punct ),A
R12453 T15342 T15343 amod Time-dependent,stimulation
R12454 T15343 T15343 ROOT stimulation,stimulation
R12455 T15344 T15343 prep of,stimulation
R12456 T15345 T15346 compound Jurkat,T-cells
R12457 T15346 T15344 pobj T-cells,of
R12458 T15347 T15343 acl using,stimulation
R12459 T15348 T15347 dobj PMA,using
R12460 T15349 T15343 punct .,stimulation
R12461 T15350 T15351 amod NF-κB,activation
R12462 T15351 T15353 nsubjpass activation,evaluated
R12463 T15352 T15353 auxpass was,evaluated
R12464 T15353 T15353 ROOT evaluated,evaluated
R12465 T15354 T15353 advcl using,evaluated
R12466 T15355 T15357 compound HK,coli
R12467 T15356 T15357 compound E.,coli
R12468 T15357 T15354 dobj coli,using
R12469 T15358 T15354 prep in,using
R12470 T15359 T15370 det a,manner
R12471 T15360 T15363 punct (,dose
R12472 T15361 T15363 nmod B,dose
R12473 T15362 T15363 punct ),dose
R12474 T15363 T15370 nmod dose,manner
R12475 T15364 T15363 punct -,dose
R12476 T15365 T15363 cc and,dose
R12477 T15366 T15363 punct (,dose
R12478 T15367 T15370 nmod C,manner
R12479 T15368 T15370 punct ),manner
R12480 T15369 T15370 amod time-dependant,manner
R12481 T15370 T15358 pobj manner,in
R12482 T15371 T15353 punct .,evaluated
R12483 T15372 T15373 compound Calcium,ionophore
R12484 T15373 T15374 nsubj ionophore,increased
R12485 T15374 T15374 ROOT increased,increased
R12486 T15375 T15376 amod NF-κB,activity
R12487 T15376 T15374 dobj activity,increased
R12488 T15377 T15374 prep following,increased
R12489 T15378 T15379 compound PMA,exposure
R12490 T15379 T15377 pobj exposure,following
R12491 T15380 T15381 punct (,E
R12492 T15381 T15379 npadvmod E,exposure
R12493 T15382 T15374 punct ),increased
R12494 T15383 T15374 cc and,increased
R12495 T15384 T15374 conj resulted,increased
R12496 T15385 T15384 prep in,resulted
R12497 T15386 T15388 det a,regulation
R12498 T15387 T15388 amod negative,regulation
R12499 T15388 T15385 pobj regulation,in
R12500 T15389 T15388 prep in,regulation
R12501 T15390 T15389 pobj response,in
R12502 T15391 T15390 prep to,response
R12503 T15392 T15395 compound HK,stimulation
R12504 T15393 T15395 compound E.,stimulation
R12505 T15394 T15395 compound coli,stimulation
R12506 T15395 T15391 pobj stimulation,to
R12507 T15396 T15397 punct (,D
R12508 T15397 T15395 appos D,stimulation
R12509 T15398 T15374 punct ),increased
R12510 T15399 T15374 punct .,increased
R12511 T15400 T15401 compound Statistical,significance
R12512 T15401 T15406 nsubjpass significance,determined
R12513 T15402 T15401 prep from,significance
R12514 T15403 T15404 det the,control
R12515 T15404 T15402 pobj control,from
R12516 T15405 T15406 auxpass was,determined
R12517 T15406 T15406 ROOT determined,determined
R12518 T15407 T15406 advcl using,determined
R12519 T15408 T15410 poss Student,t-test
R12520 T15409 T15408 case 's,Student
R12521 T15410 T15407 dobj t-test,using
R12522 T15411 T15406 punct .,determined
R12523 T15412 T15415 punct (,4
R12524 T15413 T15415 advmod n,4
R12525 T15414 T15415 punct =,4
R12526 T15415 T15421 meta 4,set
R12527 T15416 T15415 punct ),4
R12528 T15417 T15415 punct .,4
R12529 T15418 T15421 nsubjpass Controls,set
R12530 T15419 T15421 auxpass were,set
R12531 T15420 T15421 advmod arbitrarily,set
R12532 T15421 T15421 ROOT set,set
R12533 T15422 T15421 prep to,set
R12534 T15423 T15422 pobj 1,to
R12535 T15424 T15421 punct .,set
R12658 T15600 T15600 ROOT CXCL8,CXCL8
R12659 T15601 T15600 punct ",",CXCL8
R12660 T15602 T15606 nsubj IL-6,following
R12661 T15603 T15602 cc and,IL-6
R12662 T15604 T15605 compound TNF,expression
R12663 T15605 T15602 conj expression,IL-6
R12664 T15606 T15600 prep following,CXCL8
R12665 T15607 T15608 amod long-term,stimulation
R12666 T15608 T15606 pobj stimulation,following
R12667 T15609 T15608 prep with,stimulation
R12668 T15610 T15609 pobj PMA,with
R12669 T15611 T15606 punct .,following
R12670 T15612 T15613 compound Jurkat,T-cells
R12671 T15613 T15616 nsubjpass T-cells,treated
R12672 T15614 T15616 auxpass were,treated
R12673 T15615 T15616 preconj either,treated
R12674 T15616 T15616 ROOT treated,treated
R12675 T15617 T15616 prep with,treated
R12676 T15618 T15617 pobj media,with
R12677 T15619 T15618 punct (,media
R12678 T15620 T15621 amod white,bars
R12679 T15621 T15618 appos bars,media
R12680 T15622 T15616 punct ),treated
R12681 T15623 T15616 cc or,treated
R12682 T15624 T15616 conj stimulated,treated
R12683 T15625 T15624 prep with,stimulated
R12684 T15626 T15625 pobj PMA,with
R12685 T15627 T15626 punct (,PMA
R12686 T15628 T15629 amod black,bars
R12687 T15629 T15626 appos bars,PMA
R12688 T15630 T15629 punct ),bars
R12689 T15631 T15624 cc and,stimulated
R12690 T15632 T15624 conj incubated,stimulated
R12691 T15633 T15632 prep for,incubated
R12692 T15634 T15635 nummod 1,h
R12693 T15635 T15633 pobj h,for
R12694 T15636 T15635 punct ",",h
R12695 T15637 T15638 nummod 2,h
R12696 T15638 T15635 appos h,h
R12697 T15639 T15638 punct ",",h
R12698 T15640 T15641 nummod 6,h
R12699 T15641 T15638 conj h,h
R12700 T15642 T15641 cc and,h
R12701 T15643 T15644 nummod 24,h.
R12702 T15644 T15646 amod h.,media
R12703 T15645 T15646 amod Aged,media
R12704 T15646 T15641 conj media,h
R12705 T15647 T15648 auxpass was,added
R12706 T15648 T15616 conj added,treated
R12707 T15649 T15648 prep following,added
R12708 T15650 T15653 det each,representative
R12709 T15651 T15653 amod centrifugation,representative
R12710 T15652 T15653 compound step,representative
R12711 T15653 T15649 pobj representative,following
R12712 T15654 T15653 prep to,representative
R12713 T15655 T15657 det the,time
R12714 T15656 T15657 compound stimulation,time
R12715 T15657 T15654 pobj time,to
R12716 T15658 T15659 punct (,see
R12717 T15659 T15653 parataxis see,representative
R12718 T15660 T15659 dobj Materials,see
R12719 T15661 T15660 cc and,Materials
R12720 T15662 T15660 conj methods,Materials
R12721 T15663 T15659 punct ),see
R12722 T15664 T15648 punct .,added
R12723 T15665 T15666 amod Cytokine,levels
R12724 T15666 T15682 nsubjpass levels,detected
R12725 T15667 T15666 punct (,levels
R12726 T15668 T15682 nsubjpass A,detected
R12727 T15669 T15670 punct ),CXCL8
R12728 T15670 T15668 pobj CXCL8,A
R12729 T15671 T15670 punct ",",CXCL8
R12730 T15672 T15673 punct (,B
R12731 T15673 T15670 appos B,CXCL8
R12732 T15674 T15670 punct ),CXCL8
R12733 T15675 T15670 conj IL-6,CXCL8
R12734 T15676 T15675 cc and,IL-6
R12735 T15677 T15678 punct (,C
R12736 T15678 T15675 conj C,IL-6
R12737 T15679 T15678 punct ),C
R12738 T15680 T15675 conj TNF,IL-6
R12739 T15681 T15682 auxpass were,detected
R12740 T15682 T15682 ROOT detected,detected
R12741 T15683 T15682 agent by,detected
R12742 T15684 T15683 pobj ELISA,by
R12743 T15685 T15682 punct .,detected
R12744 T15686 T15687 compound Statistical,significance
R12745 T15687 T15692 nsubjpass significance,determined
R12746 T15688 T15687 prep from,significance
R12747 T15689 T15690 det the,control
R12748 T15690 T15688 pobj control,from
R12749 T15691 T15692 auxpass was,determined
R12750 T15692 T15692 ROOT determined,determined
R12751 T15693 T15692 advcl using,determined
R12752 T15694 T15696 poss Student,t-test
R12753 T15695 T15694 case 's,Student
R12754 T15696 T15693 dobj t-test,using
R12755 T15697 T15692 punct .,determined
R12756 T15698 T15701 punct (,3
R12757 T15699 T15701 advmod n,3
R12758 T15700 T15701 punct =,3
R12759 T15701 T15701 ROOT 3,3
R12760 T15702 T15701 punct ),3
R12761 T15703 T15701 punct .,3
R12889 T15876 T15876 ROOT Inhibition,Inhibition
R12890 T15877 T15876 prep of,Inhibition
R12891 T15878 T15879 amod NF-κB,activity
R12892 T15879 T15877 pobj activity,of
R12893 T15880 T15879 prep by,activity
R12894 T15881 T15880 pobj NAI,by
R12895 T15882 T15876 punct .,Inhibition
R12896 T15883 T15884 compound Jurkat,T-cells
R12897 T15884 T15886 nsubjpass T-cells,transfected
R12898 T15885 T15886 auxpass were,transfected
R12899 T15886 T15886 ROOT transfected,transfected
R12900 T15887 T15886 prep with,transfected
R12901 T15888 T15889 compound luciferase,reporter
R12902 T15889 T15890 compound reporter,plasmids
R12903 T15890 T15887 pobj plasmids,with
R12904 T15891 T15890 acl containing,plasmids
R12905 T15892 T15893 preconj either,NF-κB
R12906 T15893 T15897 nmod NF-κB,elements
R12907 T15894 T15893 cc or,NF-κB
R12908 T15895 T15893 conj AP-1,NF-κB
R12909 T15896 T15897 amod cis-acting,elements
R12910 T15897 T15891 dobj elements,containing
R12911 T15898 T15886 punct .,transfected
R12912 T15899 T15900 det The,cells
R12913 T15900 T15902 nsubjpass cells,incubated
R12914 T15901 T15902 auxpass were,incubated
R12915 T15902 T15902 ROOT incubated,incubated
R12916 T15903 T15902 prep with,incubated
R12917 T15904 T15906 amod NF-κB,inhibitor
R12918 T15905 T15906 compound activation,inhibitor
R12919 T15906 T15903 pobj inhibitor,with
R12920 T15907 T15906 punct (,inhibitor
R12921 T15908 T15906 appos NAI,inhibitor
R12922 T15909 T15906 punct ),inhibitor
R12923 T15910 T15902 prep for,incubated
R12924 T15911 T15912 nummod 1,h
R12925 T15912 T15910 pobj h,for
R12926 T15913 T15912 acl followed,h
R12927 T15914 T15913 agent by,followed
R12928 T15915 T15914 pobj stimulation,by
R12929 T15916 T15913 prep with,followed
R12930 T15917 T15916 pobj PMA,with
R12931 T15918 T15920 punct (,nM
R12932 T15919 T15920 nummod 162,nM
R12933 T15920 T15929 nmod nM,coli
R12934 T15921 T15920 punct ",",nM
R12935 T15922 T15920 conj A,nM
R12936 T15923 T15922 cc and,A
R12937 T15924 T15922 conj C,A
R12938 T15925 T15924 punct ),C
R12939 T15926 T15922 cc or,A
R12940 T15927 T15929 compound HK,coli
R12941 T15928 T15929 compound E.,coli
R12942 T15929 T15940 meta coli,for
R12943 T15930 T15929 punct (,coli
R12944 T15931 T15929 appos 5,coli
R12945 T15932 T15934 nummod ×,CFU/ml
R12946 T15933 T15934 nummod 107,CFU/ml
R12947 T15934 T15929 appos CFU/ml,coli
R12948 T15935 T15934 punct ",",CFU/ml
R12949 T15936 T15934 conj B,CFU/ml
R12950 T15937 T15936 cc and,B
R12951 T15938 T15936 conj D,B
R12952 T15939 T15929 punct ),coli
R12953 T15940 T15913 prep for,followed
R12954 T15941 T15942 nummod 24,h.
R12955 T15942 T15940 pobj h.,for
R12956 T15943 T15944 punct (,A
R12957 T15944 T15942 appos A,h.
R12958 T15945 T15948 punct ",",NF-κB
R12959 T15946 T15948 nmod B,NF-κB
R12960 T15947 T15948 punct ),NF-κB
R12961 T15948 T15944 appos NF-κB,A
R12962 T15949 T15948 punct ",",NF-κB
R12963 T15950 T15948 cc but,NF-κB
R12964 T15951 T15953 neg not,C
R12965 T15952 T15953 punct (,C
R12966 T15953 T15948 conj C,NF-κB
R12967 T15954 T15953 punct ",",C
R12968 T15955 T15953 conj D,C
R12969 T15956 T15953 punct ),C
R12970 T15957 T15959 nsubjpass AP-1,inhibited
R12971 T15958 T15959 auxpass was,inhibited
R12972 T15959 T15902 conj inhibited,incubated
R12973 T15960 T15959 punct .,inhibited
R12974 T15961 T15962 compound Statistical,significance
R12975 T15962 T15973 nsubjpass significance,determined
R12976 T15963 T15962 prep from,significance
R12977 T15964 T15966 det the,control
R12978 T15965 T15966 amod positive,control
R12979 T15966 T15963 pobj control,from
R12980 T15967 T15966 punct (,control
R12981 T15968 T15970 compound PMA/HK,coli
R12982 T15969 T15970 compound E.,coli
R12983 T15970 T15966 appos coli,control
R12984 T15971 T15966 punct ),control
R12985 T15972 T15973 auxpass was,determined
R12986 T15973 T15973 ROOT determined,determined
R12987 T15974 T15973 advcl using,determined
R12988 T15975 T15977 poss Student,t-test
R12989 T15976 T15975 case 's,Student
R12990 T15977 T15974 dobj t-test,using
R12991 T15978 T15973 punct .,determined
R12992 T15979 T15982 punct (,4
R12993 T15980 T15982 advmod n,4
R12994 T15981 T15982 punct =,4
R12995 T15982 T15987 meta 4,set
R12996 T15983 T15982 punct ),4
R12997 T15984 T15982 punct .,4
R12998 T15985 T15987 nsubjpass Controls,set
R12999 T15986 T15987 auxpass were,set
R13000 T15987 T15987 ROOT set,set
R13001 T15988 T15987 prep to,set
R13002 T15989 T15988 pobj 1,to
R13003 T15990 T15987 punct .,set
R13146 T16168 T16168 ROOT Involvement,Involvement
R13147 T16169 T16168 prep of,Involvement
R13148 T16170 T16169 pobj NF-κB,of
R13149 T16171 T16168 prep in,Involvement
R13150 T16172 T16173 compound cytokine,regulation
R13151 T16173 T16171 pobj regulation,in
R13152 T16174 T16168 punct .,Involvement
R13153 T16175 T16176 amod Cytokine/chemokine,levels
R13154 T16176 T16178 nsubjpass levels,determined
R13155 T16177 T16178 auxpass were,determined
R13156 T16178 T16178 ROOT determined,determined
R13157 T16179 T16178 advcl using,determined
R13158 T16180 T16179 dobj ELISA,using
R13159 T16181 T16178 prep following,determined
R13160 T16182 T16181 pobj incubation,following
R13161 T16183 T16182 prep of,incubation
R13162 T16184 T16185 compound Jurkat,T-cells
R13163 T16185 T16183 pobj T-cells,of
R13164 T16186 T16182 prep with,incubation
R13165 T16187 T16186 pobj NAI,with
R13166 T16188 T16190 punct (,h
R13167 T16189 T16190 nummod 1,h
R13168 T16190 T16187 appos h,NAI
R13169 T16191 T16190 punct ),h
R13170 T16192 T16190 cc and,h
R13171 T16193 T16190 conj stimulation,h
R13172 T16194 T16196 punct (,h
R13173 T16195 T16196 nummod 24,h
R13174 T16196 T16190 appos h,h
R13175 T16197 T16190 punct ),h
R13176 T16198 T16178 punct .,determined
R13177 T16199 T16206 punct (,inhibited
R13178 T16200 T16203 nmod A,expression
R13179 T16201 T16200 punct ),A
R13180 T16202 T16203 compound CXCL8,expression
R13181 T16203 T16206 nsubjpass expression,inhibited
R13182 T16204 T16206 auxpass was,inhibited
R13183 T16205 T16206 advmod partially,inhibited
R13184 T16206 T16233 advcl inhibited,indicates
R13185 T16207 T16206 prep following,inhibited
R13186 T16208 T16209 compound PMA,stimulation
R13187 T16209 T16207 pobj stimulation,following
R13188 T16210 T16212 punct (,bars
R13189 T16211 T16212 amod grey,bars
R13190 T16212 T16209 appos bars,stimulation
R13191 T16213 T16206 punct ),inhibited
R13192 T16214 T16206 punct ",",inhibited
R13193 T16215 T16220 mark whereas,altered
R13194 T16216 T16217 det the,levels
R13195 T16217 T16220 nsubjpass levels,altered
R13196 T16218 T16220 auxpass were,altered
R13197 T16219 T16220 neg not,altered
R13198 T16220 T16206 advcl altered,inhibited
R13199 T16221 T16220 prep following,altered
R13200 T16222 T16221 pobj stimulation,following
R13201 T16223 T16222 prep with,stimulation
R13202 T16224 T16226 compound HK,coli
R13203 T16225 T16226 compound E.,coli
R13204 T16226 T16223 pobj coli,with
R13205 T16227 T16226 punct (,coli
R13206 T16228 T16229 amod black,bars
R13207 T16229 T16226 appos bars,coli
R13208 T16230 T16226 punct ),coli
R13209 T16231 T16233 punct ",",indicates
R13210 T16232 T16233 nsubj this,indicates
R13211 T16233 T16233 ROOT indicates,indicates
R13212 T16234 T16235 det an,induction
R13213 T16235 T16233 dobj induction,indicates
R13214 T16236 T16237 advmod mainly,regulated
R13215 T16237 T16235 acl regulated,induction
R13216 T16238 T16237 agent by,regulated
R13217 T16239 T16238 pobj AP-1,by
R13218 T16240 T16233 punct .,indicates
R13219 T16241 T16248 punct (,affected
R13220 T16242 T16245 nmod B,expression
R13221 T16243 T16242 punct ),B
R13222 T16244 T16245 compound TNF,expression
R13223 T16245 T16248 nsubjpass expression,affected
R13224 T16246 T16248 auxpass was,affected
R13225 T16247 T16248 neg not,affected
R13226 T16248 T16248 ROOT affected,affected
R13227 T16249 T16248 agent by,affected
R13228 T16250 T16249 pobj NAI,by
R13229 T16251 T16248 punct .,affected
R13230 T16252 T16253 punct (,C
R13231 T16253 T16253 ROOT C,C
R13232 T16254 T16253 punct ),C
R13233 T16255 T16256 compound IL-6,release
R13234 T16256 T16259 nsubjpass release,inhibited
R13235 T16257 T16259 auxpass was,inhibited
R13236 T16258 T16259 advmod completely,inhibited
R13237 T16259 T16259 ROOT inhibited,inhibited
R13238 T16260 T16259 agent by,inhibited
R13239 T16261 T16260 pobj NAI,by
R13240 T16262 T16259 prep following,inhibited
R13241 T16263 T16264 compound PMA,exposure
R13242 T16264 T16262 pobj exposure,following
R13243 T16265 T16259 punct ",",inhibited
R13244 T16266 T16259 advcl indicating,inhibited
R13245 T16267 T16266 dobj regulation,indicating
R13246 T16268 T16266 prep through,indicating
R13247 T16269 T16268 pobj NF-κB,through
R13248 T16270 T16275 mark since,increased
R13249 T16271 T16272 compound IL-6,expression
R13250 T16272 T16275 nsubjpass expression,increased
R13251 T16273 T16275 auxpass was,increased
R13252 T16274 T16275 advmod significantly,increased
R13253 T16275 T16266 advcl increased,indicating
R13254 T16276 T16275 prep in,increased
R13255 T16277 T16276 pobj response,in
R13256 T16278 T16277 prep to,response
R13257 T16279 T16281 compound HK,coli
R13258 T16280 T16281 compound E.,coli
R13259 T16281 T16278 pobj coli,to
R13260 T16282 T16275 prep than,increased
R13261 T16283 T16282 pobj PMA,than
R13262 T16284 T16259 punct .,inhibited
R13263 T16285 T16286 compound Statistical,significance
R13264 T16286 T16297 nsubjpass significance,determined
R13265 T16287 T16286 prep from,significance
R13266 T16288 T16290 det the,control
R13267 T16289 T16290 amod positive,control
R13268 T16290 T16287 pobj control,from
R13269 T16291 T16290 punct (,control
R13270 T16292 T16294 compound PMA/HK,coli
R13271 T16293 T16294 compound E.,coli
R13272 T16294 T16290 appos coli,control
R13273 T16295 T16290 punct ),control
R13274 T16296 T16297 auxpass was,determined
R13275 T16297 T16297 ROOT determined,determined
R13276 T16298 T16297 advcl using,determined
R13277 T16299 T16301 poss Student,t-test
R13278 T16300 T16299 case 's,Student
R13279 T16301 T16298 dobj t-test,using
R13280 T16302 T16297 punct .,determined
R13281 T16303 T16306 punct (,3
R13282 T16304 T16306 advmod n,3
R13283 T16305 T16306 punct =,3
R13284 T16306 T16306 ROOT 3,3
R13285 T16307 T16306 punct ),3
R13286 T16308 T16306 punct .,3
R13365 T16439 T16439 ROOT Involvement,Involvement
R13366 T16440 T16439 prep of,Involvement
R13367 T16441 T16440 pobj PKC,of
R13368 T16442 T16441 cc and,PKC
R13369 T16443 T16441 conj JNK,PKC
R13370 T16444 T16439 prep in,Involvement
R13371 T16445 T16446 amod cytokine,expression
R13372 T16446 T16444 pobj expression,in
R13373 T16447 T16439 punct .,Involvement
R13374 T16448 T16449 compound Jurkat,T-cells
R13375 T16449 T16451 nsubjpass T-cells,incubated
R13376 T16450 T16451 auxpass were,incubated
R13377 T16451 T16451 ROOT incubated,incubated
R13378 T16452 T16451 prep with,incubated
R13379 T16453 T16452 pobj PKC,with
R13380 T16454 T16451 punct -,incubated
R13381 T16455 T16451 cc and,incubated
R13382 T16456 T16457 compound JNK,inhibitors
R13383 T16457 T16479 nsubjpass inhibitors,inhibited
R13384 T16458 T16457 prep for,inhibitors
R13385 T16459 T16460 nummod 1,h
R13386 T16460 T16458 pobj h,for
R13387 T16461 T16457 acl followed,inhibitors
R13388 T16462 T16461 agent by,followed
R13389 T16463 T16462 pobj stimulation,by
R13390 T16464 T16461 prep with,followed
R13391 T16465 T16464 pobj PMA,with
R13392 T16466 T16465 punct (,PMA
R13393 T16467 T16468 nummod 162,nM
R13394 T16468 T16465 appos nM,PMA
R13395 T16469 T16465 punct ),PMA
R13396 T16470 T16461 prep for,followed
R13397 T16471 T16472 nummod 24,h.
R13398 T16472 T16470 pobj h.,for
R13399 T16473 T16474 punct (,A
R13400 T16474 T16477 nmod A,expression
R13401 T16475 T16474 punct ),A
R13402 T16476 T16477 compound CXCL8,expression
R13403 T16477 T16479 nsubjpass expression,inhibited
R13404 T16478 T16479 auxpass was,inhibited
R13405 T16479 T16451 conj inhibited,incubated
R13406 T16480 T16479 prep in,inhibited
R13407 T16481 T16483 det a,manner
R13408 T16482 T16483 amod dose-dependent,manner
R13409 T16483 T16480 pobj manner,in
R13410 T16484 T16479 agent by,inhibited
R13411 T16485 T16486 det both,inhibitors
R13412 T16486 T16484 pobj inhibitors,by
R13413 T16487 T16479 punct .,inhibited
R13414 T16488 T16491 punct (,JNK-I
R13415 T16489 T16491 nmod B,JNK-I
R13416 T16490 T16491 punct ),JNK-I
R13417 T16491 T16492 nsubj JNK-I,revealed
R13418 T16492 T16492 ROOT revealed,revealed
R13419 T16493 T16496 det a,effect
R13420 T16494 T16496 amod stronger,effect
R13421 T16495 T16496 compound inhibitory,effect
R13422 T16496 T16492 dobj effect,revealed
R13423 T16497 T16496 prep on,effect
R13424 T16498 T16499 amod IL-6,expression
R13425 T16499 T16497 pobj expression,on
R13426 T16500 T16499 prep than,expression
R13427 T16501 T16502 det the,PKC-I
R13428 T16502 T16500 pobj PKC-I,than
R13429 T16503 T16492 punct .,revealed
R13430 T16504 T16511 punct (,affected
R13431 T16505 T16508 nmod C,expression
R13432 T16506 T16505 punct ),C
R13433 T16507 T16508 compound TNF,expression
R13434 T16508 T16511 nsubjpass expression,affected
R13435 T16509 T16511 auxpass was,affected
R13436 T16510 T16511 neg not,affected
R13437 T16511 T16511 ROOT affected,affected
R13438 T16512 T16511 agent by,affected
R13439 T16513 T16514 det either,inhibitor
R13440 T16514 T16512 pobj inhibitor,by
R13441 T16515 T16511 punct .,affected
R13442 T16516 T16517 compound Statistical,significance
R13443 T16517 T16526 nsubjpass significance,determined
R13444 T16518 T16517 prep from,significance
R13445 T16519 T16521 det the,control
R13446 T16520 T16521 amod positive,control
R13447 T16521 T16518 pobj control,from
R13448 T16522 T16521 punct (,control
R13449 T16523 T16521 appos PMA,control
R13450 T16524 T16521 punct ),control
R13451 T16525 T16526 auxpass was,determined
R13452 T16526 T16526 ROOT determined,determined
R13453 T16527 T16526 advcl using,determined
R13454 T16528 T16530 poss Student,t-test
R13455 T16529 T16528 case 's,Student
R13456 T16530 T16527 dobj t-test,using
R13457 T16531 T16526 punct .,determined
R13458 T16532 T16535 punct (,3
R13459 T16533 T16534 advmod n,=
R13460 T16534 T16535 punct =,3
R13461 T16535 T16535 ROOT 3,3
R13462 T16536 T16535 punct ),3
R13463 T16537 T16535 punct .,3
R13609 T16734 T16735 amod NF-κB,inhibition
R13610 T16735 T16738 nsubj inhibition,correlated
R13611 T16736 T16735 prep by,inhibition
R13612 T16737 T16736 pobj PMA,by
R13613 T16738 T16738 ROOT correlated,correlated
R13614 T16739 T16738 prep to,correlated
R13615 T16740 T16742 amod PKC-dependent,degradation
R13616 T16741 T16742 amod Bcl10,degradation
R13617 T16742 T16739 pobj degradation,to
R13618 T16743 T16738 punct .,correlated
R13619 T16744 T16749 nsubjpass Levels,assessed
R13620 T16745 T16744 prep of,Levels
R13621 T16746 T16747 amod intracellular,protein
R13622 T16747 T16745 pobj protein,of
R13623 T16748 T16749 auxpass were,assessed
R13624 T16749 T16749 ROOT assessed,assessed
R13625 T16750 T16749 prep following,assessed
R13626 T16751 T16753 nummod 24,stimulation
R13627 T16752 T16753 compound h,stimulation
R13628 T16753 T16750 pobj stimulation,following
R13629 T16754 T16753 prep with,stimulation
R13630 T16755 T16763 nmod PMA,coli
R13631 T16756 T16758 punct (,nM
R13632 T16757 T16758 nummod 162,nM
R13633 T16758 T16755 appos nM,PMA
R13634 T16759 T16758 punct ),nM
R13635 T16760 T16755 cc or,PMA
R13636 T16761 T16763 compound HK,coli
R13637 T16762 T16763 compound E.,coli
R13638 T16763 T16754 pobj coli,with
R13639 T16764 T16763 punct (,coli
R13640 T16765 T16768 nummod 5,CFU/ml
R13641 T16766 T16768 nummod ×,CFU/ml
R13642 T16767 T16768 nummod 107,CFU/ml
R13643 T16768 T16763 appos CFU/ml,coli
R13644 T16769 T16763 punct ),coli
R13645 T16770 T16749 punct .,assessed
R13646 T16771 T16774 punct (,Phospho-PKC
R13647 T16772 T16774 nmod A,Phospho-PKC
R13648 T16773 T16774 punct ),Phospho-PKC
R13649 T16774 T16775 nsubj Phospho-PKC,increased
R13650 T16775 T16775 ROOT increased,increased
R13651 T16776 T16775 prep in,increased
R13652 T16777 T16776 pobj response,in
R13653 T16778 T16777 prep to,response
R13654 T16779 T16778 pobj PMA,to
R13655 T16780 T16779 cc and,PMA
R13656 T16781 T16784 compound HK,stimulation
R13657 T16782 T16784 compound E.,stimulation
R13658 T16783 T16784 compound coli,stimulation
R13659 T16784 T16779 conj stimulation,PMA
R13660 T16785 T16775 punct .,increased
R13661 T16786 T16790 punct (,decreased
R13662 T16787 T16789 nmod B,IκB
R13663 T16788 T16789 punct ),IκB
R13664 T16789 T16790 nsubj IκB,decreased
R13665 T16790 T16790 ROOT decreased,decreased
R13666 T16791 T16790 prep following,decreased
R13667 T16792 T16791 pobj stimulation,following
R13668 T16793 T16792 prep with,stimulation
R13669 T16794 T16796 compound HK,coli
R13670 T16795 T16796 compound E.,coli
R13671 T16796 T16797 nsubj coli,indicating
R13672 T16797 T16793 pcomp indicating,with
R13673 T16798 T16799 amod NF-κB,activation
R13674 T16799 T16797 dobj activation,indicating
R13675 T16800 T16790 punct .,decreased
R13676 T16801 T16802 punct (,C
R13677 T16802 T16805 nmod C,activation
R13678 T16803 T16802 punct ),C
R13679 T16804 T16805 amod Bcl10,activation
R13680 T16805 T16807 nsubjpass activation,inhibited
R13681 T16806 T16807 auxpass was,inhibited
R13682 T16807 T16807 ROOT inhibited,inhibited
R13683 T16808 T16807 prep following,inhibited
R13684 T16809 T16810 amod long-term,stimulation
R13685 T16810 T16808 pobj stimulation,following
R13686 T16811 T16810 prep with,stimulation
R13687 T16812 T16811 pobj PMA,with
R13688 T16813 T16812 punct ",",PMA
R13689 T16814 T16815 nsubj which,explains
R13690 T16815 T16812 relcl explains,PMA
R13691 T16816 T16818 det the,effect
R13692 T16817 T16818 amod inhibitory,effect
R13693 T16818 T16815 dobj effect,explains
R13694 T16819 T16818 prep of,effect
R13695 T16820 T16819 pobj PMA,of
R13696 T16821 T16818 prep on,effect
R13697 T16822 T16823 compound NF-κB,activation
R13698 T16823 T16821 pobj activation,on
R13699 T16824 T16807 punct .,inhibited
R13700 T16825 T16827 nsubjpass β-actin,used
R13701 T16826 T16827 auxpass was,used
R13702 T16827 T16827 ROOT used,used
R13703 T16828 T16827 prep as,used
R13704 T16829 T16831 det a,control
R13705 T16830 T16831 compound loading,control
R13706 T16831 T16828 pobj control,as
R13707 T16832 T16827 punct .,used
R13708 T16833 T16836 punct (,3
R13709 T16834 T16836 advmod n,3
R13710 T16835 T16836 punct =,3
R13711 T16836 T16836 ROOT 3,3
R13712 T16837 T16836 punct ),3
R13713 T16838 T16836 punct .,3
R13840 T17006 T17007 compound Jurkat,T-cells
R13841 T17007 T17009 nsubjpass T-cells,stimulated
R13842 T17008 T17009 auxpass were,stimulated
R13843 T17009 T17009 ROOT stimulated,stimulated
R13844 T17010 T17009 prep with,stimulated
R13845 T17011 T17013 nummod 162,PMA
R13846 T17012 T17013 compound nM,PMA
R13847 T17013 T17010 pobj PMA,with
R13848 T17014 T17013 cc and,PMA
R13849 T17015 T17021 nummod 5,coli
R13850 T17016 T17021 nummod ×,coli
R13851 T17017 T17021 nummod 107,coli
R13852 T17018 T17021 compound CFU/ml,coli
R13853 T17019 T17021 compound HK,coli
R13854 T17020 T17021 compound E.,coli
R13855 T17021 T17013 conj coli,PMA
R13856 T17022 T17021 prep for,coli
R13857 T17023 T17024 nummod 24,h.
R13858 T17024 T17022 pobj h.,for
R13878 T17047 T17048 compound Jurkat,T-cells
R13879 T17048 T17050 nsubjpass T-cells,treated
R13880 T17049 T17050 auxpass were,treated
R13881 T17050 T17050 ROOT treated,treated
R13882 T17051 T17050 prep with,treated
R13883 T17052 T17054 nummod 10,NAI
R13884 T17053 T17054 compound nM,NAI
R13885 T17054 T17051 pobj NAI,with
R13886 T17055 T17054 punct ",",NAI
R13891 T17060 T17061 compound nM,PKC-I
R13892 T17061 T17054 appos PKC-I,NAI
R13893 T17062 T17050 prep for,treated
R13894 T17063 T17064 nummod 2,h
R13895 T17064 T17062 pobj h,for
R13896 T17065 T17050 advcl followed,treated
R13897 T17066 T17065 agent by,followed
R13898 T17067 T17066 pobj induction,by
R13899 T17068 T17067 prep with,induction
R13900 T17069 T17071 nummod 162,PMA
R13901 T17070 T17071 compound nM,PMA
R13902 T17071 T17068 pobj PMA,with
R13903 T17072 T17065 prep for,followed
R13904 T17073 T17074 nummod 24,h.
R13905 T17074 T17072 pobj h.,for
R4866 T6048 T6049 nsubj that,acts
R4867 T6049 T6047 relcl acts,protein
R4868 T6050 T6049 advmod upstream,acts
R4869 T6051 T6050 prep of,upstream
R4870 T6052 T6051 pobj NF-κB,of
R4871 T6053 T6049 prep in,acts
R4872 T6054 T6053 pobj concert,in
R4873 T6055 T6054 prep with,concert
R4874 T6056 T6055 pobj CARMA1,with
R4875 T6057 T6056 cc and,CARMA1
R4876 T6058 T6056 conj MALT1,CARMA1
R4877 T6059 T6049 cc and,acts
R4878 T6060 T6062 aux has,suggested
R4879 T6061 T6062 auxpass been,suggested
R4880 T6062 T6044 conj suggested,is
R4881 T6063 T6065 aux to,regulate
R4882 T6064 T6065 advmod directly,regulate
R4883 T6065 T6062 xcomp regulate,suggested
R4884 T6066 T6067 amod NF-κB,activity
R4885 T6067 T6065 dobj activity,regulate
R4886 T6068 T6065 prep in,regulate
R4887 T6069 T6068 pobj T-cells,in
R4888 T6070 T6072 nmod [,]
R4889 T6071 T6072 nummod 27,]
R4890 T6072 T6069 appos ],T-cells
R4914 T6096 T6095 punct ",",h
R4915 T6097 T6095 cc and,h
R4916 T6098 T6099 nummod 24,h
R4917 T6099 T6095 conj h,h
R4918 T6100 T6085 advcl using,stimulated
R4919 T6101 T6103 amod western,analysis
R4920 T6102 T6103 compound blot,analysis
R4921 T6103 T6100 dobj analysis,using
R4922 T6104 T6079 punct .,evaluated
R4923 T6105 T6107 det The,levels
R4924 T6106 T6107 amod Bcl10,levels
R4925 T6107 T6108 nsubj levels,decreased
R4926 T6108 T6108 ROOT decreased,decreased
R4927 T6109 T6108 prep following,decreased
R4928 T6110 T6109 pobj treatment,following
R4929 T6111 T6110 prep with,treatment
R4930 T6112 T6111 pobj PMA,with
R4931 T6113 T6108 punct ",",decreased
R4932 T6114 T6120 mark while,returned
R4933 T6115 T6120 prep in,returned
R4934 T6116 T6117 compound control,cells
R4935 T6117 T6115 pobj cells,in
R4936 T6118 T6120 punct ",",returned
R4937 T6119 T6120 nsubj Bcl10,returned
R4938 T6120 T6108 advcl returned,decreased
R4939 T6121 T6120 prep to,returned
R4940 T6122 T6123 amod higher,levels
R4941 T6123 T6121 pobj levels,to
R4942 T6124 T6123 prep by,levels
R4943 T6125 T6126 nummod 24,h
R4944 T6126 T6124 pobj h,by
R3853 T4804 T4800 ccomp down-regulated,showed
R4861 T6043 T6044 nsubj Bcl10,is
R4862 T6044 T6044 ROOT is,is
R4863 T6045 T6047 det a,protein
R4864 T6046 T6047 amod signalling,protein
R4865 T6047 T6044 attr protein,is
R4910 T6092 T6089 appos h,min
R4911 T6093 T6092 punct ",",h
R4912 T6094 T6095 nummod 6,h
R4913 T6095 T6092 conj h,h
R13887 T17056 T17058 nummod 10,JNK-I
R13888 T17057 T17058 compound μM,JNK-I
R13889 T17058 T17054 appos JNK-I,NAI
R13890 T17059 T17061 compound or10,PKC-I

GO-BP

Id Subject Object Predicate Lexical cue
T3782 507-517 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3783 551-561 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3784 1142-1152 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3785 53-66 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3786 358-371 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3787 129-150 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T3788 182-191 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T3789 182-205 http://purl.obolibrary.org/obo/GO_0090195 denotes secretion of chemokines
T3790 237-258 http://purl.obolibrary.org/obo/GO_1902107 denotes activate immune cells
T3791 237-258 http://purl.obolibrary.org/obo/GO_0045321 denotes activate immune cells
T3792 237-258 http://purl.obolibrary.org/obo/GO_0002694 denotes activate immune cells
T3793 273-279 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T3794 273-292 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T3795 273-301 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathways
T3796 273-301 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathways
T3797 273-301 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathways
T3798 273-301 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathways
T3799 280-292 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T3800 330-348 http://purl.obolibrary.org/obo/GO_0042089 denotes cytokine induction
T3801 484-502 http://purl.obolibrary.org/obo/GO_0042089 denotes cytokine induction
T3802 820-829 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T3803 1042-1045 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T3804 2278-2297 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T4404 3311-3333 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T4405 3381-3402 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T4406 3814-3835 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T4407 3998-4008 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T4408 4059-4069 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T4409 4107-4125 http://purl.obolibrary.org/obo/GO_0042089 denotes cytokine induction
T4410 4129-4144 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T4411 4578-4588 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5548 5422-5444 http://purl.obolibrary.org/obo/GO_0042089 denotes induction of cytokines
T5549 5524-5534 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T5550 6284-6294 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T5551 8040-8050 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T5552 8258-8268 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T5553 5561-5577 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T5554 5650-5666 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T5555 5561-5587 http://purl.obolibrary.org/obo/GO_1903721 denotes NF-κB activation inhibitor
T5556 6279-6294 http://purl.obolibrary.org/obo/GO_0032675 denotes IL-6 regulation
T5557 6279-6294 http://purl.obolibrary.org/obo/GO_0045408 denotes IL-6 regulation
T5558 7723-7726 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T5559 7817-7820 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T5560 7966-7969 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5561 8017-8020 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5562 8226-8229 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5563 8542-8545 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5564 8079-8092 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T5565 8116-8131 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5569 8192-8201 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T5570 8391-8393 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T5571 8514-8529 http://purl.obolibrary.org/obo/GO_0032088 denotes NF-κB inhibitor
T5572 8514-8529 http://purl.obolibrary.org/obo/GO_0007252 denotes NF-κB inhibitor
T6304 9658-9661 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T6305 9756-9759 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T6306 9678-9689 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6307 9727-9737 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T6308 9897-9907 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T6309 10404-10420 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15272 1438-1453 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T15273 1607-1616 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T15274 1647-1650 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T15539 2656-2666 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T15540 2681-2691 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T15541 3117-3127 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T15542 2926-2942 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15543 3028-3037 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T15544 3108-3139 http://purl.obolibrary.org/obo/GO_1901032 denotes negative regulation in response
T15545 3108-3139 http://purl.obolibrary.org/obo/GO_1901458 denotes negative regulation in response
T15546 3108-3139 http://purl.obolibrary.org/obo/GO_0031348 denotes negative regulation in response
T15547 3108-3139 http://purl.obolibrary.org/obo/GO_0050728 denotes negative regulation in response
T15548 3108-3139 http://purl.obolibrary.org/obo/GO_0048585 denotes negative regulation in response
T15549 3108-3139 http://purl.obolibrary.org/obo/GO_1901420 denotes negative regulation in response
T15550 3108-3139 http://purl.obolibrary.org/obo/GO_1901443 denotes negative regulation in response
T15551 3108-3139 http://purl.obolibrary.org/obo/GO_0050777 denotes negative regulation in response
T15552 3108-3139 http://purl.obolibrary.org/obo/GO_0050687 denotes negative regulation in response
T16108 6492-6508 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T16109 6492-6518 http://purl.obolibrary.org/obo/GO_1903721 denotes NF-κB activation inhibitor
T16319 6866-6876 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16320 7364-7374 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16636 8752-8755 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16637 8823-8826 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16638 9065-9068 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16639 8760-8763 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T16640 8832-8835 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T16641 8993-8996 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T16942 10470-10473 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16943 10638-10641 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16944 10490-10501 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T16945 10655-10670 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T16946 10766-10782 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T16947 10908-10924 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T17104 9293-9296 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T17105 9307-9310 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T5566 8116-8146 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation and activation
T5567 8183-8191 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T5568 8192-8201 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis

GO-MF

Id Subject Object Predicate Lexical cue
T3805 820-829 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T4412 3582-3586 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T4413 3588-3592 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4414 4213-4217 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4415 4504-4508 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4416 3668-3673 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T5573 6149-6153 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T5574 6279-6283 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T5575 7899-7903 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T5576 8287-8291 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T5577 7723-7726 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T5578 7817-7820 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T5579 7966-7969 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5580 8017-8020 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5581 8226-8229 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5582 8542-8545 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5583 8391-8393 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T6310 9658-9661 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T6311 9756-9759 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T15275 1607-1616 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T15553 3028-3037 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T15814 4607-4611 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T15815 4965-4969 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16321 7284-7288 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16322 7395-7399 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16642 8752-8755 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16643 8823-8826 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16644 9065-9068 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16645 8760-8763 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T16646 8832-8835 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T16647 8993-8996 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T16648 9040-9044 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16948 10470-10473 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T16949 10638-10641 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17106 9293-9296 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T17107 9307-9310 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC

GO-CC

Id Subject Object Predicate Lexical cue
T3806 253-258 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5584 5547-5552 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5585 5761-5766 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5586 6088-6093 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5587 7712-7717 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15554 2780-2785 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15555 2909-2914 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3807 723-728 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3808 806-811 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3809 2098-2103 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3810 1042-1045 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T3811 2492-2505 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T4417 3415-3420 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4418 3852-3857 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6312 9793-9798 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6313 10041-10046 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6314 10130-10135 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6315 10272-10277 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16110 6352-6357 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16111 6466-6471 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16323 6965-6970 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16649 8797-8802 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16950 10513-10526 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T15276 1286-1291 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15277 1309-1314 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15278 1664-1669 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15279 1647-1650 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T15816 4682-4687 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17045 5114-5119 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17108 9252-9257 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T3051 49-259 Sentence denotes The transcription factors NF-κB and AP-1 play key roles in the initiation of an inflammatory response by inducing the expression and secretion of chemokines and cytokines that attract and activate immune cells.
T3052 260-404 Sentence denotes However, the signal transduction pathways and subsequent inflammatory cytokine induction by these transcription factors is not fully elucidated.
T3053 405-518 Sentence denotes The present study is aimed at determining the involvement of AP-1 and NF-κB in cytokine induction and regulation.
T3054 519-658 Sentence denotes PMA treatment resulted in an up-regulation of AP-1 after 2 h exposure and continued to increase throughout the analysis period (figure 1a).
T3055 659-741 Sentence denotes HK E. coli treatment did not affect AP-1 activation in Jurkat T-cells (figure 1b).
T3056 742-999 Sentence denotes To determine the involvement of associated pathways, we exposed cells to Ca2+ ionophore with or without PMA and observed a modest involvement of Ca2+ in PMA-dependent AP-1 activation (figure 1c) while Ca2+ alone did not alter AP-1 activity (data not shown).
T3057 1000-1218 Sentence denotes Furthermore, AP-1 activity decreased in a TCR-deficient Jurkat cell line when exposed to PMA compared to the parent cell line indicating that regulation of AP-1 was only partially T-cell receptor dependent (figure 1d).
T3058 1856-1940 Sentence denotes NF-κB levels showed a transient increase at 1 min after exposure to PMA (figure 2a).
T3059 1941-2076 Sentence denotes However, 1 h after exposure the NF-κB levels began to drop reaching the lowest levels by 6 h, after which they increased again by 24 h.
T3060 2077-2258 Sentence denotes Exposure of Jurkat T-cells to HK E. coli resulted in a dose-dependent NF-κB activation, with the highest activity observed at a relative concentration of 5 × 107 CFU/ml (figure 2b).
T3061 2259-2468 Sentence denotes The time-dependent activation of NF-κB by HK E. coli was assessed further using the optimal concentration obtained from figure 2b and showed that the NF-κB activity increased after 3 h of exposure (figure 2c).
T3062 2469-2634 Sentence denotes Furthermore, increased intracellular Ca2+ reversed the PMA dependent NF-κB inhibition (figure 2d) and reduced the HK E. coli -dependent NF-κB activation (figure 2e).
T3931 3298-3333 Sentence denotes Induction of inflammatory responses
T3932 3334-3495 Sentence denotes The ability of PMA and HK E. coli to induce an inflammatory response in Jurkat T-cells was evaluated using a multiplex cytokine assay following 24 h stimulation.
T3933 3496-3622 Sentence denotes The cytokine profile revealed an enhanced induction of the pro-inflammatory cytokines IL-2, IL-6, TNF and the chemokine CXCL8.
T3934 3623-3754 Sentence denotes The levels of the anti-inflammatory cytokine IL-10 were unaffected by PMA but were significantly decreased by HK E. coli (Table 1).
T3935 3755-3858 Sentence denotes These results confirmed that PMA and HK E. coli induced an inflammatory response in the Jurkat T-cells.
T3936 3859-3956 Sentence denotes It is interesting to note that PMA was 120-fold more effective at inducing CXCL8 than HK E. coli.
T3937 3957-4070 Sentence denotes PMA-dependent induction of AP-1 and down-regulation of NF-κB suggests an involvement of AP-1 in CXCL8 regulation.
T3938 4071-4258 Sentence denotes Determination of the time course of cytokine induction in response to PMA showed that CXCL8 was already released between 2-6 h, while TNF and IL-6 were released between 6-24 h (figure 3).
T3939 4259-4416 Sentence denotes These results indicated that the cytokines were differentially regulated and that the release was not associated with the early transient induction of NF-κB.
T3940 4417-4517 Sentence denotes The temporal induction of AP-1 correlated to the CXCL8 levels and preceded the TNF and IL-6 release.
T3941 4518-4589 Sentence denotes This suggests an association between CXCL8 release and AP-1 signalling.
T4753 5410-5462 Sentence denotes Cooperative induction of cytokines by AP-1 and NF-κB
T4754 5463-5594 Sentence denotes To further characterize the involvement of NF-κB in cytokine regulation, we treated cells with an NF-κB activation inhibitor (NAI).
T4755 5595-5739 Sentence denotes The results showed that NAI selectively down-regulated NF-κB activation (figures 4a and 4b) and did not alter AP-1 activity (figures 4c and 4d).
T4756 5740-5921 Sentence denotes Exposure of Jurkat T-cells to NAI resulted in a modest reduction of CXCL8 following PMA exposure, while it did not alter the CXCL8 release following HK E. coli exposure (figure 5a).
T4757 5922-6094 Sentence denotes NAI did not affect TNF expression (figure 5b) indicating that NF-κB is not the main regulator of CXCL8 or TNF following either PMA or HK E. coli exposure in Jurkat T-cells.
T4758 6095-6295 Sentence denotes In contrast, NAI resulted in a complete inhibition of IL-6 following PMA exposure and a 45% inhibition following HK E. coli exposure (figure 5c), suggesting an involvement of NF-κB in IL-6 regulation.
T4759 7593-7802 Sentence denotes Ca2+ was observed to increase AP-1 activity (figure 1c) and reduce NF-κB activity (figure 2e); therefore, we exposed T-cells to a PKC inhibitor together with PMA to determine its effect on cytokine expression.
T4760 7803-7926 Sentence denotes Inhibition of PKC reduced CXCL8 release from 7 ng/ml to 3 ng/ml while it had a modest effect on IL-6 and TNF (figure 6a-c).
T4761 7927-8016 Sentence denotes This prompted us to test the effect of JNK inhibition on PMA-induced cytokine expression.
T4762 8017-8207 Sentence denotes JNK is involved in the regulation of a multitude of different transcription factors, including the phosphorylation and activation of c-Jun, c-Fos and p53, leading to cellular apoptosis [26].
T4763 8208-8360 Sentence denotes Inhibition of the JNK pathways resulted in a down-regulation of both CXCL8 and IL-6, while no clear effect was observed on TNF expression (figure 6a-c).
T4764 8361-8497 Sentence denotes Analysis of mRNA levels using RT-qPCR (table 2) showed that PMA induced both il-6 and cxcl8 mRNA (5.1-fold and 111.8 fold respectively).
T4765 8498-8603 Sentence denotes Addition of the NF-κB inhibitor NAI and the JNK inhibitor reduced the il-6 expression below basal levels.
T4766 8604-8726 Sentence denotes In contrast, while the cxcl8 levels were suppressed by the same treatments the levels remained elevated above basal level.
T5994 9634-9689 Sentence denotes NF-κB inhibition due to PKC-dependent Bcl10 degradation
T5995 9690-9885 Sentence denotes Western blot analysis revealed an up-regulation of phosphorylated-PKC after 24 h treatment of Jurkat T-cells with PMA or HK E. coli (figure 7a), while IκBβ levels remained unaffected (figure 7b).
T5996 9886-10052 Sentence denotes Bcl10 is a signalling protein that acts upstream of NF-κB in concert with CARMA1 and MALT1 and has been suggested to directly regulate NF-κB activity in T-cells [27].
T5997 10053-10197 Sentence denotes Therefore, Bcl10 activation was evaluated in both control and PMA stimulated cells after 10 min, 1 h, 6 h, and 24 h using western blot analysis.
T5998 10198-10331 Sentence denotes The Bcl10 levels decreased following treatment with PMA, while in control cells, Bcl10 returned to higher levels by 24 h (figure 7c).
T5999 10332-10421 Sentence denotes This suggests that Bcl10 is involved in the PMA dependent inhibition of NF-κB activation.
T15023 1229-1299 Sentence denotes AP-1 activation following long-term exposure of Jurkat T-cells to PMA.
T15024 1300-1727 Sentence denotes Jurkat T-cells were transfected with luciferase reporter plasmids containing the AP-1 cis-elements. (A) Time-dependent AP-1 activation in response to PMA. (B) HK E. coli does not activate AP-1. (C) Dose-dependent activation of AP-1 were performed using PMA alone (grey bars) and in combination with calcium ionophore (CaI 955 μM, black bars). (D) TCR-/- deficient cells responded to PMA (162 nM) by up-regulating AP-1 activity.
T15025 1728-1817 Sentence denotes Statistical significance from the control was determined using Student's t-test. (n = 4).
T15026 1818-1853 Sentence denotes Controls were arbitrarily set to 1.
T15303 2645-2754 Sentence denotes NF-κB down-regulation by PMA and up-regulation by heat killed E. coli MG1655 following long-term stimulation.
T15304 2755-2925 Sentence denotes Transfection of Jurkat T-cells was performed using luciferase reporter plasmids containing NF-κB cis-elements. (A) Time-dependent stimulation of Jurkat T-cells using PMA.
T15305 2926-3019 Sentence denotes NF-κB activation was evaluated using HK E. coli in a (B) dose- and (C) time-dependant manner.
T15306 3020-3170 Sentence denotes Calcium ionophore increased NF-κB activity following PMA exposure (E) and resulted in a negative regulation in response to HK E. coli stimulation (D).
T15307 3171-3260 Sentence denotes Statistical significance from the control was determined using Student's t-test. (n = 4).
T15308 3261-3296 Sentence denotes Controls were arbitrarily set to 1.
T15595 4600-4672 Sentence denotes CXCL8, IL-6 and TNF expression following long-term stimulation with PMA.
T15596 4673-4809 Sentence denotes Jurkat T-cells were either treated with media (white bars) or stimulated with PMA (black bars) and incubated for 1 h, 2 h, 6 h and 24 h.
T15597 4810-4933 Sentence denotes Aged media was added following each centrifugation step representative to the stimulation time (see Materials and methods).
T15598 4934-5005 Sentence denotes Cytokine levels (A) CXCL8, (B) IL-6 and (C) TNF were detected by ELISA.
T15599 5006-5095 Sentence denotes Statistical significance from the control was determined using Student's t-test. (n = 3).
T15871 6306-6342 Sentence denotes Inhibition of NF-κB activity by NAI.
T15872 6343-6461 Sentence denotes Jurkat T-cells were transfected with luciferase reporter plasmids containing either NF-κB or AP-1 cis-acting elements.
T15873 6462-6682 Sentence denotes The cells were incubated with NF-κB activation inhibitor (NAI) for 1 h followed by stimulation with PMA (162 nM, A and C) or HK E. coli (5 × 107 CFU/ml, B and D) for 24 h. (A, B) NF-κB, but not (C, D) AP-1 was inhibited.
T15874 6683-6798 Sentence denotes Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 4).
T15875 6799-6822 Sentence denotes Controls were set to 1.
T16165 6833-6877 Sentence denotes Involvement of NF-κB in cytokine regulation.
T16166 6878-7474 Sentence denotes Cytokine/chemokine levels were determined using ELISA following incubation of Jurkat T-cells with NAI (1 h) and stimulation (24 h). (A) CXCL8 expression was partially inhibited following PMA stimulation (grey bars), whereas the levels were not altered following stimulation with HK E. coli (black bars), this indicates an induction mainly regulated by AP-1. (B) TNF expression was not affected by NAI. (C) IL-6 release was completely inhibited by NAI following PMA exposure, indicating regulation through NF-κB since IL-6 expression was significantly increased in response to HK E. coli than PMA.
T16167 7475-7590 Sentence denotes Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 3).
T16436 8737-8787 Sentence denotes Involvement of PKC and JNK in cytokine expression.
T16437 8788-9128 Sentence denotes Jurkat T-cells were incubated with PKC- and JNK inhibitors for 1 h followed by stimulation with PMA (162 nM) for 24 h. (A) CXCL8 expression was inhibited in a dose-dependent manner by both inhibitors. (B) JNK-I revealed a stronger inhibitory effect on IL-6 expression than the PKC-I. (C) TNF expression was not affected by either inhibitor.
T16438 9129-9233 Sentence denotes Statistical significance from the positive control (PMA) was determined using Student's t-test. (n = 3).
T16732 10432-10502 Sentence denotes NF-κB inhibition by PMA correlated to PKC-dependent Bcl10 degradation.
T16733 10503-10973 Sentence denotes Levels of intracellular protein were assessed following 24 h stimulation with PMA (162 nM) or HK E. coli (5 × 107 CFU/ml). (A) Phospho-PKC increased in response to PMA and HK E. coli stimulation. (B) IκB decreased following stimulation with HK E. coli indicating NF-κB activation. (C) Bcl10 activation was inhibited following long-term stimulation with PMA, which explains the inhibitory effect of PMA on NF-κB activation. β-actin was used as a loading control. (n = 3).
T17005 5105-5191 Sentence denotes Jurkat T-cells were stimulated with 162 nM PMA and 5 × 107 CFU/ml HK E. coli for 24 h.
T17046 9243-9368 Sentence denotes Jurkat T-cells were treated with 10 nM NAI, 10 μM JNK-I or10 nM PKC-I for 2 h followed by induction with 162 nM PMA for 24 h.
T37 0-7 Sentence denotes Results
T38 9-48 Sentence denotes Regulation of AP-1 and NF-κB activation
T39 49-259 Sentence denotes The transcription factors NF-κB and AP-1 play key roles in the initiation of an inflammatory response by inducing the expression and secretion of chemokines and cytokines that attract and activate immune cells.
T40 260-404 Sentence denotes However, the signal transduction pathways and subsequent inflammatory cytokine induction by these transcription factors is not fully elucidated.
T41 405-518 Sentence denotes The present study is aimed at determining the involvement of AP-1 and NF-κB in cytokine induction and regulation.
T42 519-658 Sentence denotes PMA treatment resulted in an up-regulation of AP-1 after 2 h exposure and continued to increase throughout the analysis period (figure 1a).
T43 659-741 Sentence denotes HK E. coli treatment did not affect AP-1 activation in Jurkat T-cells (figure 1b).
T44 742-999 Sentence denotes To determine the involvement of associated pathways, we exposed cells to Ca2+ ionophore with or without PMA and observed a modest involvement of Ca2+ in PMA-dependent AP-1 activation (figure 1c) while Ca2+ alone did not alter AP-1 activity (data not shown).
T45 1000-1218 Sentence denotes Furthermore, AP-1 activity decreased in a TCR-deficient Jurkat cell line when exposed to PMA compared to the parent cell line indicating that regulation of AP-1 was only partially T-cell receptor dependent (figure 1d).
T46 1219-1299 Sentence denotes Figure 1 AP-1 activation following long-term exposure of Jurkat T-cells to PMA.
T47 1300-1727 Sentence denotes Jurkat T-cells were transfected with luciferase reporter plasmids containing the AP-1 cis-elements. (A) Time-dependent AP-1 activation in response to PMA. (B) HK E. coli does not activate AP-1. (C) Dose-dependent activation of AP-1 were performed using PMA alone (grey bars) and in combination with calcium ionophore (CaI 955 μM, black bars). (D) TCR-/- deficient cells responded to PMA (162 nM) by up-regulating AP-1 activity.
T48 1728-1817 Sentence denotes Statistical significance from the control was determined using Student's t-test. (n = 4).
T49 1818-1853 Sentence denotes Controls were arbitrarily set to 1.
T50 1856-1940 Sentence denotes NF-κB levels showed a transient increase at 1 min after exposure to PMA (figure 2a).
T51 1941-2076 Sentence denotes However, 1 h after exposure the NF-κB levels began to drop reaching the lowest levels by 6 h, after which they increased again by 24 h.
T52 2077-2258 Sentence denotes Exposure of Jurkat T-cells to HK E. coli resulted in a dose-dependent NF-κB activation, with the highest activity observed at a relative concentration of 5 × 107 CFU/ml (figure 2b).
T53 2259-2468 Sentence denotes The time-dependent activation of NF-κB by HK E. coli was assessed further using the optimal concentration obtained from figure 2b and showed that the NF-κB activity increased after 3 h of exposure (figure 2c).
T54 2469-2634 Sentence denotes Furthermore, increased intracellular Ca2+ reversed the PMA dependent NF-κB inhibition (figure 2d) and reduced the HK E. coli -dependent NF-κB activation (figure 2e).
T55 2635-2754 Sentence denotes Figure 2 NF-κB down-regulation by PMA and up-regulation by heat killed E. coli MG1655 following long-term stimulation.
T56 2755-2925 Sentence denotes Transfection of Jurkat T-cells was performed using luciferase reporter plasmids containing NF-κB cis-elements. (A) Time-dependent stimulation of Jurkat T-cells using PMA.
T57 2926-3019 Sentence denotes NF-κB activation was evaluated using HK E. coli in a (B) dose- and (C) time-dependant manner.
T58 3020-3170 Sentence denotes Calcium ionophore increased NF-κB activity following PMA exposure (E) and resulted in a negative regulation in response to HK E. coli stimulation (D).
T59 3171-3260 Sentence denotes Statistical significance from the control was determined using Student's t-test. (n = 4).
T60 3261-3296 Sentence denotes Controls were arbitrarily set to 1.
T61 3298-3333 Sentence denotes Induction of inflammatory responses
T62 3334-3495 Sentence denotes The ability of PMA and HK E. coli to induce an inflammatory response in Jurkat T-cells was evaluated using a multiplex cytokine assay following 24 h stimulation.
T63 3496-3622 Sentence denotes The cytokine profile revealed an enhanced induction of the pro-inflammatory cytokines IL-2, IL-6, TNF and the chemokine CXCL8.
T64 3623-3754 Sentence denotes The levels of the anti-inflammatory cytokine IL-10 were unaffected by PMA but were significantly decreased by HK E. coli (Table 1).
T65 3755-3858 Sentence denotes These results confirmed that PMA and HK E. coli induced an inflammatory response in the Jurkat T-cells.
T66 3859-3956 Sentence denotes It is interesting to note that PMA was 120-fold more effective at inducing CXCL8 than HK E. coli.
T67 3957-4070 Sentence denotes PMA-dependent induction of AP-1 and down-regulation of NF-κB suggests an involvement of AP-1 in CXCL8 regulation.
T68 4071-4258 Sentence denotes Determination of the time course of cytokine induction in response to PMA showed that CXCL8 was already released between 2-6 h, while TNF and IL-6 were released between 6-24 h (figure 3).
T69 4259-4416 Sentence denotes These results indicated that the cytokines were differentially regulated and that the release was not associated with the early transient induction of NF-κB.
T70 4417-4517 Sentence denotes The temporal induction of AP-1 correlated to the CXCL8 levels and preceded the TNF and IL-6 release.
T71 4518-4589 Sentence denotes This suggests an association between CXCL8 release and AP-1 signalling.
T72 4590-4672 Sentence denotes Figure 3 CXCL8, IL-6 and TNF expression following long-term stimulation with PMA.
T73 4673-4809 Sentence denotes Jurkat T-cells were either treated with media (white bars) or stimulated with PMA (black bars) and incubated for 1 h, 2 h, 6 h and 24 h.
T74 4810-4933 Sentence denotes Aged media was added following each centrifugation step representative to the stimulation time (see Materials and methods).
T75 4934-5005 Sentence denotes Cytokine levels (A) CXCL8, (B) IL-6 and (C) TNF were detected by ELISA.
T76 5006-5095 Sentence denotes Statistical significance from the control was determined using Student's t-test. (n = 3).
T77 5096-5191 Sentence denotes Table 1 Jurkat T-cells were stimulated with 162 nM PMA and 5 × 107 CFU/ml HK E. coli for 24 h.
T78 5193-5248 Sentence denotes Cytokine levels were determined using multiplex assays.
T79 5249-5323 Sentence denotes Concentrations are given as pg/ml for each group (mean value ± SD, n = 3).
T80 5324-5408 Sentence denotes Statistical significance from the control (C) was determined using Student's t-test.
T81 5410-5462 Sentence denotes Cooperative induction of cytokines by AP-1 and NF-κB
T82 5463-5594 Sentence denotes To further characterize the involvement of NF-κB in cytokine regulation, we treated cells with an NF-κB activation inhibitor (NAI).
T83 5595-5739 Sentence denotes The results showed that NAI selectively down-regulated NF-κB activation (figures 4a and 4b) and did not alter AP-1 activity (figures 4c and 4d).
T84 5740-5921 Sentence denotes Exposure of Jurkat T-cells to NAI resulted in a modest reduction of CXCL8 following PMA exposure, while it did not alter the CXCL8 release following HK E. coli exposure (figure 5a).
T85 5922-6094 Sentence denotes NAI did not affect TNF expression (figure 5b) indicating that NF-κB is not the main regulator of CXCL8 or TNF following either PMA or HK E. coli exposure in Jurkat T-cells.
T86 6095-6295 Sentence denotes In contrast, NAI resulted in a complete inhibition of IL-6 following PMA exposure and a 45% inhibition following HK E. coli exposure (figure 5c), suggesting an involvement of NF-κB in IL-6 regulation.
T87 6296-6342 Sentence denotes Figure 4 Inhibition of NF-κB activity by NAI.
T88 6343-6461 Sentence denotes Jurkat T-cells were transfected with luciferase reporter plasmids containing either NF-κB or AP-1 cis-acting elements.
T89 6462-6682 Sentence denotes The cells were incubated with NF-κB activation inhibitor (NAI) for 1 h followed by stimulation with PMA (162 nM, A and C) or HK E. coli (5 × 107 CFU/ml, B and D) for 24 h. (A, B) NF-κB, but not (C, D) AP-1 was inhibited.
T90 6683-6798 Sentence denotes Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 4).
T91 6799-6822 Sentence denotes Controls were set to 1.
T92 6823-6877 Sentence denotes Figure 5 Involvement of NF-κB in cytokine regulation.
T93 6878-7474 Sentence denotes Cytokine/chemokine levels were determined using ELISA following incubation of Jurkat T-cells with NAI (1 h) and stimulation (24 h). (A) CXCL8 expression was partially inhibited following PMA stimulation (grey bars), whereas the levels were not altered following stimulation with HK E. coli (black bars), this indicates an induction mainly regulated by AP-1. (B) TNF expression was not affected by NAI. (C) IL-6 release was completely inhibited by NAI following PMA exposure, indicating regulation through NF-κB since IL-6 expression was significantly increased in response to HK E. coli than PMA.
T94 7475-7590 Sentence denotes Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 3).
T95 7593-7802 Sentence denotes Ca2+ was observed to increase AP-1 activity (figure 1c) and reduce NF-κB activity (figure 2e); therefore, we exposed T-cells to a PKC inhibitor together with PMA to determine its effect on cytokine expression.
T96 7803-7926 Sentence denotes Inhibition of PKC reduced CXCL8 release from 7 ng/ml to 3 ng/ml while it had a modest effect on IL-6 and TNF (figure 6a-c).
T97 7927-8016 Sentence denotes This prompted us to test the effect of JNK inhibition on PMA-induced cytokine expression.
T98 8017-8207 Sentence denotes JNK is involved in the regulation of a multitude of different transcription factors, including the phosphorylation and activation of c-Jun, c-Fos and p53, leading to cellular apoptosis [26].
T99 8208-8360 Sentence denotes Inhibition of the JNK pathways resulted in a down-regulation of both CXCL8 and IL-6, while no clear effect was observed on TNF expression (figure 6a-c).
T100 8361-8497 Sentence denotes Analysis of mRNA levels using RT-qPCR (table 2) showed that PMA induced both il-6 and cxcl8 mRNA (5.1-fold and 111.8 fold respectively).
T101 8498-8603 Sentence denotes Addition of the NF-κB inhibitor NAI and the JNK inhibitor reduced the il-6 expression below basal levels.
T102 8604-8726 Sentence denotes In contrast, while the cxcl8 levels were suppressed by the same treatments the levels remained elevated above basal level.
T103 8727-8787 Sentence denotes Figure 6 Involvement of PKC and JNK in cytokine expression.
T104 8788-9128 Sentence denotes Jurkat T-cells were incubated with PKC- and JNK inhibitors for 1 h followed by stimulation with PMA (162 nM) for 24 h. (A) CXCL8 expression was inhibited in a dose-dependent manner by both inhibitors. (B) JNK-I revealed a stronger inhibitory effect on IL-6 expression than the PKC-I. (C) TNF expression was not affected by either inhibitor.
T105 9129-9233 Sentence denotes Statistical significance from the positive control (PMA) was determined using Student's t-test. (n = 3).
T106 9234-9368 Sentence denotes Table 2 Jurkat T-cells were treated with 10 nM NAI, 10 μM JNK-I or10 nM PKC-I for 2 h followed by induction with 162 nM PMA for 24 h.
T107 9370-9415 Sentence denotes Gene expression was determined using RT-qPCR.
T108 9416-9458 Sentence denotes The Ct values were normalized against 18S.
T109 9459-9554 Sentence denotes Statistical significance from the positive control (PMA) was determined using Student's t-test.
T110 9555-9632 Sentence denotes Concentrations are given as fg/ml, values are presented as mean ± SEM, n = 3.
T111 9634-9689 Sentence denotes NF-κB inhibition due to PKC-dependent Bcl10 degradation
T112 9690-9885 Sentence denotes Western blot analysis revealed an up-regulation of phosphorylated-PKC after 24 h treatment of Jurkat T-cells with PMA or HK E. coli (figure 7a), while IκBβ levels remained unaffected (figure 7b).
T113 9886-10052 Sentence denotes Bcl10 is a signalling protein that acts upstream of NF-κB in concert with CARMA1 and MALT1 and has been suggested to directly regulate NF-κB activity in T-cells [27].
T114 10053-10197 Sentence denotes Therefore, Bcl10 activation was evaluated in both control and PMA stimulated cells after 10 min, 1 h, 6 h, and 24 h using western blot analysis.
T115 10198-10331 Sentence denotes The Bcl10 levels decreased following treatment with PMA, while in control cells, Bcl10 returned to higher levels by 24 h (figure 7c).
T116 10332-10421 Sentence denotes This suggests that Bcl10 is involved in the PMA dependent inhibition of NF-κB activation.
T117 10422-10502 Sentence denotes Figure 7 NF-κB inhibition by PMA correlated to PKC-dependent Bcl10 degradation.
T118 10503-10973 Sentence denotes Levels of intracellular protein were assessed following 24 h stimulation with PMA (162 nM) or HK E. coli (5 × 107 CFU/ml). (A) Phospho-PKC increased in response to PMA and HK E. coli stimulation. (B) IκB decreased following stimulation with HK E. coli indicating NF-κB activation. (C) Bcl10 activation was inhibited following long-term stimulation with PMA, which explains the inhibitory effect of PMA on NF-κB activation. β-actin was used as a loading control. (n = 3).

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T4537 3529-3537 Positive_regulation denotes enhanced
T4538 3538-3547 Positive_regulation denotes induction
T4539 3582-3586 Protein denotes IL-2
T4540 3588-3592 Protein denotes IL-6
T4541 3616-3621 Protein denotes CXCL8
T4542 3668-3673 Protein denotes IL-10
T4543 3679-3689 Regulation denotes unaffected true
T4544 3720-3729 Negative_regulation denotes decreased
T4545 3912-3921 Positive_regulation denotes effective
T4546 3925-3933 Positive_regulation denotes inducing
T4547 3934-3939 Protein denotes CXCL8
T4548 4030-4041 Regulation denotes involvement true
T4549 4053-4058 Protein denotes CXCL8
T4550 4059-4069 Regulation denotes regulation
T4551 4157-4162 Protein denotes CXCL8
T4552 4175-4183 Localization denotes released
T4553 4213-4217 Protein denotes IL-6
T4554 4223-4231 Localization denotes released
T4555 4322-4331 Regulation denotes regulated
T4556 4322-4331 Regulation denotes regulated
T4557 4466-4471 Protein denotes CXCL8
T4558 4504-4508 Protein denotes IL-6
T4559 4509-4516 Localization denotes release
T4560 4555-4560 Protein denotes CXCL8
T4561 4561-4568 Localization denotes release
T5819 5795-5804 Negative_regulation denotes reduction
T5820 5808-5813 Protein denotes CXCL8
T5821 5814-5823 Positive_regulation denotes following
T5822 5855-5860 Regulation denotes alter true
T5823 5865-5870 Protein denotes CXCL8
T5824 5871-5878 Localization denotes release
T5825 5879-5888 Positive_regulation denotes following
T5826 6006-6015 Regulation denotes regulator true
T5827 6019-6024 Protein denotes CXCL8
T5828 6032-6041 Positive_regulation denotes following
T5829 6135-6145 Negative_regulation denotes inhibition
T5830 6149-6153 Protein denotes IL-6
T5831 6154-6163 Positive_regulation denotes following
T5832 6187-6197 Negative_regulation denotes inhibition
T5833 6198-6207 Positive_regulation denotes following
T5834 6255-6266 Regulation denotes involvement true
T5835 6279-6283 Protein denotes IL-6
T5836 6284-6294 Regulation denotes regulation
T5837 7821-7828 Negative_regulation denotes reduced
T5838 7829-7834 Protein denotes CXCL8
T5839 7835-7842 Localization denotes release
T5840 7889-7895 Regulation denotes effect
T5841 7899-7903 Protein denotes IL-6
T5842 8116-8131 Phosphorylation denotes phosphorylation
T5843 8116-8131 Phosphorylation denotes phosphorylation
T5844 8116-8131 Phosphorylation denotes phosphorylation
T5845 8136-8146 Positive_regulation denotes activation
T5846 8136-8146 Positive_regulation denotes activation
T5847 8136-8146 Positive_regulation denotes activation
T5848 8150-8155 Protein denotes c-Jun
T5849 8157-8162 Protein denotes c-Fos
T5850 8167-8170 Protein denotes p53
T5851 8239-8247 Positive_regulation denotes resulted
T5852 8239-8247 Positive_regulation denotes resulted
T5853 8253-8268 Negative_regulation denotes down-regulation
T5854 8253-8268 Negative_regulation denotes down-regulation
T5855 8277-8282 Protein denotes CXCL8
T5856 8287-8291 Protein denotes IL-6
T5857 8425-8432 Positive_regulation denotes induced
T5858 8425-8432 Positive_regulation denotes induced
T5859 8438-8442 Protein denotes il-6
T5860 8447-8452 Protein denotes cxcl8
T5861 8453-8457 Transcription denotes mRNA
T5862 8453-8457 Transcription denotes mRNA
T5863 8556-8563 Negative_regulation denotes reduced
T5864 8568-8572 Protein denotes il-6
T5865 8573-8583 Transcription denotes expression
T5866 8627-8632 Protein denotes cxcl8
T5867 8633-8639 Transcription denotes levels
T5868 8645-8655 Negative_regulation denotes suppressed
T5869 8690-8698 Regulation denotes remained true
T5870 8699-8707 Positive_regulation denotes elevated
T6385 9662-9671 Regulation denotes dependent
T6386 9672-9677 Protein denotes Bcl10
T6387 9678-9689 Protein_catabolism denotes degradation
T6388 9841-9845 Protein denotes IκBβ
T6389 9862-9872 Regulation denotes unaffected true
T6390 9886-9891 Protein denotes Bcl10
T6391 9960-9966 Protein denotes CARMA1
T6392 9971-9976 Protein denotes MALT1
T6393 10064-10069 Protein denotes Bcl10
T6394 10070-10080 Positive_regulation denotes activation true
T6395 10202-10207 Protein denotes Bcl10
T6396 10215-10224 Negative_regulation denotes decreased
T6397 10279-10284 Protein denotes Bcl10
T6398 10285-10303 Positive_regulation denotes returned to higher
T6399 10351-10356 Protein denotes Bcl10
T15853 4600-4605 Protein denotes CXCL8
T15854 4607-4611 Protein denotes IL-6
T15855 4620-4630 Gene_expression denotes expression
T15856 4620-4630 Gene_expression denotes expression
T15857 4631-4640 Positive_regulation denotes following true
T15858 4631-4640 Positive_regulation denotes following true
T15859 4954-4959 Protein denotes CXCL8
T15860 4965-4969 Protein denotes IL-6
T16383 7014-7019 Protein denotes CXCL8
T16384 7020-7030 Gene_expression denotes expression
T16385 7045-7054 Negative_regulation denotes inhibited
T16386 7122-7129 Regulation denotes altered true
T16387 7200-7209 Positive_regulation denotes induction
T16388 7217-7226 Regulation denotes regulated
T16389 7284-7288 Protein denotes IL-6
T16390 7289-7296 Localization denotes release
T16391 7312-7321 Negative_regulation denotes inhibited
T16392 7364-7374 Regulation denotes regulation
T16393 7395-7399 Protein denotes IL-6
T16394 7400-7410 Gene_expression denotes expression
T16395 7429-7438 Positive_regulation denotes increased
T16687 8911-8916 Protein denotes CXCL8
T16688 8917-8927 Gene_expression denotes expression
T16689 8932-8941 Negative_regulation denotes inhibited
T16690 8952-8961 Regulation denotes dependent
T16691 9019-9036 Negative_regulation denotes inhibitory effect
T16692 9040-9044 Protein denotes IL-6
T16693 9045-9055 Gene_expression denotes expression
T16984 10474-10483 Regulation denotes dependent
T16985 10484-10489 Protein denotes Bcl10
T16986 10490-10501 Protein_catabolism denotes degradation
T16987 10788-10793 Protein denotes Bcl10
T16988 10794-10804 Positive_regulation denotes activation
T16989 10809-10818 Negative_regulation denotes inhibited
T16990 10926-10933 Protein denotes β-actin
T15286 1337-1347 Protein denotes luciferase
T15561 2806-2816 Protein denotes luciferase
T16117 6380-6390 Protein denotes luciferase
R3677 T4538 T4537 themeOf induction,enhanced
R3678 T4541 T4538 themeOf CXCL8,induction
R3679 T4542 T4543 themeOf IL-10,unaffected
R3680 T4542 T4544 themeOf IL-10,decreased
R3681 T4546 T4545 themeOf inducing,effective
R3682 T4547 T4546 themeOf CXCL8,inducing
R3683 T4549 T4550 themeOf CXCL8,regulation
R3684 T4550 T4548 themeOf regulation,involvement
R3685 T4551 T4552 themeOf CXCL8,released
R3686 T4551 T4555 themeOf CXCL8,regulated
R3687 T4553 T4554 themeOf IL-6,released
R3688 T4553 T4556 themeOf IL-6,regulated
R3689 T4558 T4559 themeOf IL-6,release
R3690 T4560 T4561 themeOf CXCL8,release
R4719 T5820 T5821 themeOf CXCL8,following
R4720 T5821 T5819 themeOf following,reduction
R4721 T5823 T5824 themeOf CXCL8,release
R4722 T5824 T5825 themeOf release,following
R4723 T5825 T5822 themeOf following,alter
R4724 T5827 T5828 themeOf CXCL8,following
R4725 T5828 T5826 themeOf following,regulator
R4726 T5830 T5829 themeOf IL-6,inhibition
R4727 T5830 T5831 themeOf IL-6,following
R4728 T5830 T5832 themeOf IL-6,inhibition
R4729 T5830 T5833 themeOf IL-6,following
R4730 T5835 T5836 themeOf IL-6,regulation
R4731 T5836 T5834 themeOf regulation,involvement
R4732 T5838 T5839 themeOf CXCL8,release
R4733 T5839 T5837 themeOf release,reduced
R4734 T5841 T5840 themeOf IL-6,effect
R4735 T5848 T5844 themeOf c-Jun,phosphorylation
R4736 T5848 T5845 themeOf c-Jun,activation
R4737 T5849 T5842 themeOf c-Fos,phosphorylation
R4738 T5849 T5846 themeOf c-Fos,activation
R4739 T5850 T5843 themeOf p53,phosphorylation
R4740 T5850 T5847 themeOf p53,activation
R4741 T5853 T5852 themeOf down-regulation,resulted
R4742 T5854 T5851 themeOf down-regulation,resulted
R4743 T5855 T5854 themeOf CXCL8,down-regulation
R4744 T5856 T5853 themeOf IL-6,down-regulation
R4745 T5859 T5862 themeOf il-6,mRNA
R4746 T5860 T5861 themeOf cxcl8,mRNA
R4747 T5861 T5857 themeOf mRNA,induced
R4748 T5862 T5858 themeOf mRNA,induced
R4749 T5864 T5865 themeOf il-6,expression
R4750 T5865 T5863 themeOf expression,reduced
R4751 T5866 T5867 themeOf cxcl8,levels
R4752 T5867 T5868 themeOf levels,suppressed
R4753 T5867 T5870 themeOf levels,elevated
R4754 T5870 T5869 themeOf elevated,remained
R5132 T6386 T6387 themeOf Bcl10,degradation
R5133 T6387 T6385 themeOf degradation,dependent
R5134 T6388 T6389 themeOf IκBβ,unaffected
R5135 T6393 T6394 themeOf Bcl10,activation
R5136 T6395 T6396 themeOf Bcl10,decreased
R5137 T6397 T6398 themeOf Bcl10,returned to higher
R12882 T15853 T15856 themeOf CXCL8,expression
R12883 T15854 T15855 themeOf IL-6,expression
R12884 T15855 T15857 themeOf expression,following
R12885 T15856 T15858 themeOf expression,following
R13331 T16383 T16384 themeOf CXCL8,expression
R13332 T16384 T16385 themeOf expression,inhibited
R13333 T16384 T16386 themeOf expression,altered
R13334 T16384 T16387 themeOf expression,induction
R13335 T16387 T16388 themeOf induction,regulated
R13336 T16389 T16390 themeOf IL-6,release
R13337 T16390 T16392 themeOf release,regulation
R13338 T16390 T16391 themeOf release,inhibited
R13339 T16393 T16394 themeOf IL-6,expression
R13340 T16394 T16395 themeOf expression,increased
R13584 T16687 T16688 themeOf CXCL8,expression
R13585 T16688 T16689 themeOf expression,inhibited
R13586 T16689 T16690 themeOf inhibited,dependent
R13587 T16692 T16693 themeOf IL-6,expression
R13588 T16693 T16691 themeOf expression,inhibitory effect
R13831 T16985 T16986 themeOf Bcl10,degradation
R13832 T16986 T16984 themeOf degradation,dependent
R13833 T16987 T16988 themeOf Bcl10,activation
R13834 T16988 T16989 themeOf activation,inhibited

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T3813 32-37 Protein denotes NF-κB
T3814 38-48 Positive_regulation denotes activation
T3815 38-48 Positive_regulation denotes activation
T3818 38-48 Positive_regulation denotes activation
T3819 38-48 Positive_regulation denotes activation
T3820 75-80 Protein denotes NF-κB
T3821 85-89 Protein denotes AP-1
T3822 182-191 Localization denotes secretion
T3823 182-191 Localization denotes secretion
T3824 154-162 Positive_regulation denotes inducing
T3825 154-162 Positive_regulation denotes inducing
T3826 154-162 Positive_regulation denotes inducing
T3827 154-162 Positive_regulation denotes inducing
T3828 154-162 Positive_regulation denotes inducing
T3829 154-162 Positive_regulation denotes inducing
T3831 475-480 Protein denotes NF-κB
T3832 507-517 Regulation denotes regulation
T3833 507-517 Regulation denotes regulation
T3834 695-699 Protein denotes AP-1
T3835 700-710 Positive_regulation denotes activation
T3836 688-694 Regulation denotes affect
T3837 968-972 Protein denotes AP-1
T3838 1013-1017 Protein denotes AP-1
T3839 1042-1045 Protein denotes TCR
T3840 1156-1160 Protein denotes AP-1
T3841 1027-1036 Negative_regulation denotes decreased
T3842 1046-1055 Negative_regulation denotes deficient
T3843 1142-1152 Regulation denotes regulation
T3844 1856-1861 Protein denotes NF-κB
T3845 1888-1896 Positive_regulation denotes increase
T3846 1973-1978 Protein denotes NF-κB
T3847 2107-2111 Protein denotes HK E
T3848 2147-2152 Protein denotes NF-κB
T3849 2153-2163 Positive_regulation denotes activation
T3850 2292-2297 Protein denotes NF-κB
T3851 2301-2311 Protein denotes HK E. coli
T3852 2409-2414 Protein denotes NF-κB
T3853 2278-2288 Positive_regulation denotes activation
T3854 2424-2433 Positive_regulation denotes increased
T3855 2524-2543 Protein denotes PMA dependent NF-κB
T3856 2583-2610 Protein denotes HK E. coli -dependent NF-κB
T3857 2544-2554 Negative_regulation denotes inhibition
T3858 2611-2621 Positive_regulation denotes activation
T3859 2571-2578 Negative_regulation denotes reduced
T4562 3572-3586 Protein denotes cytokines IL-2
T4563 3588-3592 Protein denotes IL-6
T4564 3594-3597 Protein denotes TNF
T4565 3616-3621 Protein denotes CXCL8
T4566 3538-3547 Positive_regulation denotes induction
T4567 3538-3547 Positive_regulation denotes induction
T4568 3538-3547 Positive_regulation denotes induction
T4569 3538-3547 Positive_regulation denotes induction
T4570 3529-3537 Positive_regulation denotes enhanced
T4571 3529-3537 Positive_regulation denotes enhanced
T4572 3529-3537 Positive_regulation denotes enhanced
T4573 3529-3537 Positive_regulation denotes enhanced
T4574 3659-3673 Protein denotes cytokine IL-10
T4575 3679-3689 Regulation denotes unaffected
T4576 3720-3729 Negative_regulation denotes decreased
T4577 3934-3939 Protein denotes CXCL8
T4578 3925-3933 Positive_regulation denotes inducing
T4579 3984-3988 Protein denotes AP-1
T4580 4012-4017 Protein denotes NF-κB
T4581 4045-4049 Protein denotes AP-1
T4582 4053-4058 Protein denotes CXCL8
T4583 3993-4008 Negative_regulation denotes down-regulation
T4584 4059-4069 Regulation denotes regulation
T4585 3971-3980 Positive_regulation denotes induction
T4586 4157-4162 Protein denotes CXCL8
T4587 4205-4208 Protein denotes TNF
T4588 4213-4217 Protein denotes IL-6
T4589 4175-4183 Localization denotes released
T4590 4223-4231 Localization denotes released
T4591 4223-4231 Localization denotes released
T4592 4410-4415 Protein denotes NF-κB
T4593 4397-4406 Positive_regulation denotes induction
T4594 4443-4447 Protein denotes AP-1
T4595 4466-4471 Protein denotes CXCL8
T4596 4496-4499 Protein denotes TNF
T4597 4504-4508 Protein denotes IL-6
T4598 4430-4439 Positive_regulation denotes induction
T4599 4509-4516 Localization denotes release
T4600 4509-4516 Localization denotes release
T4601 4483-4491 Positive_regulation denotes preceded
T4602 4483-4491 Positive_regulation denotes preceded
T4603 4555-4568 Protein denotes CXCL8 release
T4604 4573-4577 Protein denotes AP-1
T5872 5457-5462 Protein denotes NF-κB
T5873 5506-5511 Protein denotes NF-κB
T5874 5561-5566 Protein denotes NF-κB
T5875 5650-5655 Protein denotes NF-κB
T5876 5705-5709 Protein denotes AP-1
T5877 5656-5666 Positive_regulation denotes activation
T5878 5699-5704 Regulation denotes alter
T5879 5635-5649 Negative_regulation denotes down-regulated
T5880 5808-5813 Protein denotes CXCL8
T5881 5865-5878 Protein denotes CXCL8 release
T5882 5889-5893 Protein denotes HK E
T5883 5795-5804 Negative_regulation denotes reduction
T5884 5855-5860 Regulation denotes alter
T5885 5941-5944 Protein denotes TNF
T5886 5984-5989 Protein denotes NF-κB
T5887 6019-6024 Protein denotes CXCL8
T5888 6028-6031 Protein denotes TNF
T5889 5945-5955 Gene_expression denotes expression
T5890 6006-6015 Regulation denotes regulator
T5891 5934-5940 Regulation denotes affect
T5892 6149-6153 Protein denotes IL-6
T5893 6270-6275 Protein denotes NF-κB
T5894 6279-6283 Protein denotes IL-6
T5895 6135-6145 Negative_regulation denotes inhibition
T5896 6284-6294 Regulation denotes regulation
T5897 6255-6266 Regulation denotes involvement
T5898 7623-7627 Protein denotes AP-1
T5899 7660-7665 Protein denotes NF-κB
T5900 7723-7726 Protein denotes PKC
T5901 7614-7622 Positive_regulation denotes increase
T5902 7653-7659 Negative_regulation denotes reduce
T5903 7727-7736 Negative_regulation denotes inhibitor
T5904 7817-7820 Protein denotes PKC
T5905 7829-7834 Protein denotes CXCL8
T5906 7899-7903 Protein denotes IL-6
T5907 7908-7911 Protein denotes TNF
T5908 7803-7813 Negative_regulation denotes Inhibition
T5909 7835-7842 Localization denotes release
T5910 7889-7895 Positive_regulation denotes effect
T5911 7889-7895 Positive_regulation denotes effect
T5912 7821-7828 Negative_regulation denotes reduced
T5913 7966-7969 Protein denotes JNK
T5914 7970-7980 Negative_regulation denotes inhibition
T5915 7956-7962 Regulation denotes effect
T5916 8017-8020 Protein denotes JNK
T5917 8150-8155 Protein denotes c-Jun
T5918 8157-8162 Protein denotes c-Fos
T5919 8167-8170 Protein denotes p53
T5920 8116-8131 Phosphorylation denotes phosphorylation
T5921 8116-8131 Phosphorylation denotes phosphorylation
T5922 8116-8131 Phosphorylation denotes phosphorylation
T5923 8136-8146 Positive_regulation denotes activation
T5924 8136-8146 Positive_regulation denotes activation
T5925 8136-8146 Positive_regulation denotes activation
T5926 8040-8050 Regulation denotes regulation
T5927 8040-8050 Regulation denotes regulation
T5928 8040-8050 Regulation denotes regulation
T5929 8040-8050 Regulation denotes regulation
T5930 8040-8050 Regulation denotes regulation
T5931 8040-8050 Regulation denotes regulation
T5932 8226-8229 Protein denotes JNK
T5933 8277-8282 Protein denotes CXCL8
T5934 8287-8291 Protein denotes IL-6
T5935 8331-8334 Protein denotes TNF
T5936 8208-8218 Negative_regulation denotes Inhibition
T5937 8253-8268 Negative_regulation denotes down-regulation
T5938 8253-8268 Negative_regulation denotes down-regulation
T5939 8335-8345 Gene_expression denotes expression
T5940 8239-8247 Negative_regulation denotes resulted
T5941 8239-8247 Negative_regulation denotes resulted
T5942 8308-8314 Regulation denotes effect
T5943 8447-8457 Protein denotes cxcl8 mRNA
T5944 8425-8432 Positive_regulation denotes induced
T5945 8514-8519 Protein denotes NF-κB
T5946 8542-8545 Protein denotes JNK
T5947 8546-8555 Negative_regulation denotes inhibitor
T6400 9634-9639 Protein denotes NF-κB
T6401 9658-9661 Protein denotes PKC
T6402 9640-9650 Negative_regulation denotes inhibition
T6403 9678-9689 Protein_catabolism denotes degradation
T6404 9678-9689 Protein_catabolism denotes degradation
T6405 9640-9650 Negative_regulation denotes inhibition
T6406 9640-9650 Negative_regulation denotes inhibition
T6407 9841-9845 Protein denotes IκBβ
T6408 9862-9872 Regulation denotes unaffected
T6409 9886-9891 Protein denotes Bcl10
T6410 9938-9943 Protein denotes NF-κB
T6411 9960-9966 Protein denotes CARMA1
T6412 9971-9976 Protein denotes MALT1
T6413 10021-10026 Protein denotes NF-κB
T6414 10012-10020 Regulation denotes regulate
T6415 10064-10069 Protein denotes Bcl10
T6416 10070-10080 Positive_regulation denotes activation
T6417 10202-10207 Protein denotes Bcl10
T6418 10279-10284 Protein denotes Bcl10
T6419 10215-10224 Negative_regulation denotes decreased
T6420 10351-10356 Protein denotes Bcl10
T6421 10404-10409 Protein denotes NF-κB
T6422 10410-10420 Positive_regulation denotes activation
T6423 10390-10400 Negative_regulation denotes inhibition
T15287 1229-1233 Protein denotes AP-1
T15288 1234-1244 Positive_regulation denotes activation
T15289 1337-1347 Protein denotes luciferase
T15290 1381-1385 Protein denotes AP-1
T15291 1419-1423 Protein denotes AP-1
T15292 1424-1434 Positive_regulation denotes activation
T15293 1488-1492 Protein denotes AP-1
T15294 1479-1487 Positive_regulation denotes activate
T15295 1527-1531 Protein denotes AP-1
T15296 1618-1628 Protein denotes CaI 955 μM
T15297 1513-1523 Positive_regulation denotes activation
T15298 1713-1717 Protein denotes AP-1
T15299 1699-1712 Positive_regulation denotes up-regulating
T15562 2645-2650 Protein denotes NF-κB
T15563 2651-2666 Negative_regulation denotes down-regulation
T15564 2678-2691 Positive_regulation denotes up-regulation
T15565 2651-2666 Negative_regulation denotes down-regulation
T15566 2806-2816 Protein denotes luciferase
T15567 2846-2851 Protein denotes NF-κB
T15568 2926-2931 Protein denotes NF-κB
T15569 2932-2942 Positive_regulation denotes activation
T15570 3048-3053 Protein denotes NF-κB
T15571 3143-3145 Protein denotes HK
T15572 3038-3047 Positive_regulation denotes increased
T15861 4600-4605 Protein denotes CXCL8
T15862 4607-4611 Protein denotes IL-6
T15863 4616-4619 Protein denotes TNF
T15864 4620-4630 Gene_expression denotes expression
T15865 4620-4630 Gene_expression denotes expression
T15866 4620-4630 Gene_expression denotes expression
T15867 4954-4959 Protein denotes CXCL8
T16118 6320-6325 Protein denotes NF-κB
T16119 6306-6316 Negative_regulation denotes Inhibition
T16120 6380-6390 Protein denotes luciferase
T16121 6427-6432 Protein denotes NF-κB
T16122 6436-6440 Protein denotes AP-1
T16123 6492-6497 Protein denotes NF-κB
T16124 6641-6646 Protein denotes NF-κB
T16125 6672-6681 Negative_regulation denotes inhibited
T16396 6848-6853 Protein denotes NF-κB
T16397 6866-6876 Regulation denotes regulation
T16398 7014-7019 Protein denotes CXCL8
T16399 7157-7161 Protein denotes HK E
T16400 7230-7234 Protein denotes AP-1
T16401 7020-7030 Gene_expression denotes expression
T16402 7045-7054 Negative_regulation denotes inhibited
T16403 7240-7243 Protein denotes TNF
T16404 7244-7254 Gene_expression denotes expression
T16405 7263-7271 Regulation denotes affected
T16406 7383-7388 Protein denotes NF-κB
T16407 7395-7399 Protein denotes IL-6
T16408 7454-7456 Protein denotes HK
T16409 7400-7410 Gene_expression denotes expression
T16410 7429-7438 Positive_regulation denotes increased
T16411 7364-7374 Regulation denotes regulation
T16694 8752-8755 Protein denotes PKC
T16695 8760-8763 Protein denotes JNK
T16696 8823-8826 Protein denotes PKC
T16697 8832-8835 Protein denotes JNK
T16698 8836-8846 Negative_regulation denotes inhibitors
T16699 8836-8846 Negative_regulation denotes inhibitors
T16700 8911-8916 Protein denotes CXCL8
T16701 8917-8927 Gene_expression denotes expression
T16702 8932-8941 Negative_regulation denotes inhibited
T16703 8993-8998 Protein denotes JNK-I
T16704 9040-9044 Protein denotes IL-6
T16705 9065-9070 Protein denotes PKC-I
T16706 9045-9055 Gene_expression denotes expression
T16707 9076-9079 Protein denotes TNF
T16708 9080-9090 Gene_expression denotes expression
T16709 9099-9107 Regulation denotes affected
T16991 10432-10437 Protein denotes NF-κB
T16992 10470-10473 Protein denotes PKC
T16993 10438-10448 Negative_regulation denotes inhibition
T16994 10490-10501 Protein_catabolism denotes degradation
T16995 10703-10706 Protein denotes IκB
T16996 10744-10748 Protein denotes HK E
T16997 10766-10771 Protein denotes NF-κB
T16998 10772-10782 Positive_regulation denotes activation
T16999 10785-10786 Protein denotes C
T17000 10788-10793 Protein denotes Bcl10
T17001 10908-10913 Protein denotes NF-κB
T17002 10926-10933 Protein denotes β-actin
T17003 10794-10804 Positive_regulation denotes activation
T17004 10809-10818 Negative_regulation denotes inhibited
T5871 5448-5452 Protein denotes AP-1
T3830 466-470 Protein denotes AP-1
T17109 9293-9296 Protein denotes JNK
T17110 9297-9312 Protein denotes I or10 nM PKC-I
R3109 T3813 T3815 themeOf NF-κB,activation
R3114 T3820 T3822 themeOf NF-κB,secretion
R3115 T3820 T3826 causeOf NF-κB,inducing
R3117 T3821 T3823 themeOf AP-1,secretion
R3120 T3822 T3824 themeOf secretion,inducing
R3123 T3823 T3825 themeOf secretion,inducing
R3135 T3850 T3853 themeOf NF-κB,activation
R3136 T3851 T3853 causeOf HK E. coli,activation
R3137 T3852 T3854 themeOf NF-κB,increased
R3138 T3855 T3857 themeOf PMA dependent NF-κB,inhibition
R3139 T3856 T3858 themeOf HK E. coli -dependent NF-κB,activation
R3140 T3858 T3859 themeOf activation,reduced
R3691 T4562 T4566 themeOf cytokines IL-2,induction
R3692 T4563 T4567 themeOf IL-6,induction
R3693 T4564 T4568 themeOf TNF,induction
R3694 T4565 T4569 themeOf CXCL8,induction
R3695 T4566 T4570 themeOf induction,enhanced
R3696 T4567 T4571 themeOf induction,enhanced
R3697 T4568 T4572 themeOf induction,enhanced
R3698 T4569 T4573 themeOf induction,enhanced
R3699 T4574 T4575 themeOf cytokine IL-10,unaffected
R3700 T4574 T4576 themeOf cytokine IL-10,decreased
R3701 T4577 T4578 themeOf CXCL8,inducing
R3702 T4580 T4583 themeOf NF-κB,down-regulation
R3703 T4582 T4584 themeOf CXCL8,regulation
R3704 T4583 T4585 themeOf down-regulation,induction
R3705 T4586 T4589 themeOf CXCL8,released
R3706 T4587 T4590 themeOf TNF,released
R3707 T4588 T4591 themeOf IL-6,released
R3708 T4592 T4593 themeOf NF-κB,induction
R3709 T4594 T4598 themeOf AP-1,induction
R3710 T4596 T4599 themeOf TNF,release
R3711 T4597 T4600 themeOf IL-6,release
R3712 T4599 T4601 themeOf release,preceded
R3713 T4600 T4602 themeOf release,preceded
R4755 T5875 T5877 themeOf NF-κB,activation
R4756 T5876 T5878 themeOf AP-1,alter
R4757 T5877 T5879 themeOf activation,down-regulated
R4758 T5880 T5883 themeOf CXCL8,reduction
R4759 T5881 T5884 themeOf CXCL8 release,alter
R4760 T5885 T5889 themeOf TNF,expression
R4761 T5886 T5890 themeOf NF-κB,regulator
R4762 T5889 T5891 themeOf expression,affect
R4763 T5892 T5895 themeOf IL-6,inhibition
R4764 T5893 T5897 causeOf NF-κB,involvement
R4765 T5894 T5896 themeOf IL-6,regulation
R4766 T5896 T5897 themeOf regulation,involvement
R4767 T5898 T5901 themeOf AP-1,increase
R4768 T5899 T5902 themeOf NF-κB,reduce
R4769 T5900 T5903 themeOf PKC,inhibitor
R4770 T5904 T5908 themeOf PKC,Inhibition
R4771 T5905 T5909 themeOf CXCL8,release
R4772 T5906 T5910 themeOf IL-6,effect
R4773 T5907 T5911 themeOf TNF,effect
R4774 T5908 T5912 causeOf Inhibition,reduced
R4775 T5909 T5912 themeOf release,reduced
R4776 T5913 T5914 themeOf JNK,inhibition
R4777 T5914 T5915 themeOf inhibition,effect
R4778 T5917 T5920 themeOf c-Jun,phosphorylation
R4779 T5918 T5921 themeOf c-Fos,phosphorylation
R4780 T5919 T5922 themeOf p53,phosphorylation
R4781 T5920 T5923 themeOf phosphorylation,activation
R4782 T5920 T5926 themeOf phosphorylation,regulation
R4783 T5921 T5924 themeOf phosphorylation,activation
R4784 T5921 T5927 themeOf phosphorylation,regulation
R4785 T5922 T5925 themeOf phosphorylation,activation
R4786 T5922 T5928 themeOf phosphorylation,regulation
R4787 T5923 T5929 themeOf activation,regulation
R4788 T5924 T5930 themeOf activation,regulation
R4789 T5925 T5931 themeOf activation,regulation
R4790 T5932 T5936 themeOf JNK,Inhibition
R4791 T5933 T5937 themeOf CXCL8,down-regulation
R4792 T5934 T5938 themeOf IL-6,down-regulation
R4793 T5935 T5939 themeOf TNF,expression
R4794 T5936 T5940 causeOf Inhibition,resulted
R4795 T5936 T5941 causeOf Inhibition,resulted
R4796 T5937 T5940 themeOf down-regulation,resulted
R4797 T5938 T5941 themeOf down-regulation,resulted
R4798 T5939 T5942 themeOf expression,effect
R4799 T5943 T5944 themeOf cxcl8 mRNA,induced
R4800 T5946 T5947 themeOf JNK,inhibitor
R5138 T6400 T6402 themeOf NF-κB,inhibition
R5139 T6400 T6403 themeOf NF-κB,degradation
R5140 T6401 T6404 themeOf PKC,degradation
R5141 T6403 T6405 themeOf degradation,inhibition
R5142 T6404 T6406 themeOf degradation,inhibition
R5143 T6407 T6408 themeOf IκBβ,unaffected
R5144 T6413 T6414 themeOf NF-κB,regulate
R5145 T6415 T6416 themeOf Bcl10,activation
R5146 T6417 T6419 themeOf Bcl10,decreased
R5147 T6421 T6422 themeOf NF-κB,activation
R5148 T6422 T6423 themeOf activation,inhibition
R12415 T15287 T15288 themeOf AP-1,activation
R12416 T15291 T15292 themeOf AP-1,activation
R12417 T15293 T15294 themeOf AP-1,activate
R12418 T15295 T15297 themeOf AP-1,activation
R12419 T15298 T15299 themeOf AP-1,up-regulating
R12642 T15562 T15563 themeOf NF-κB,down-regulation
R12643 T15563 T15564 themeOf down-regulation,up-regulation
R12644 T15564 T15565 themeOf up-regulation,down-regulation
R12645 T15568 T15569 themeOf NF-κB,activation
R12646 T15570 T15572 themeOf NF-κB,increased
R12886 T15861 T15864 themeOf CXCL8,expression
R12887 T15862 T15865 themeOf IL-6,expression
R12888 T15863 T15866 themeOf TNF,expression
R13114 T16118 T16119 themeOf NF-κB,Inhibition
R13115 T16124 T16125 themeOf NF-κB,inhibited
R13341 T16396 T16397 themeOf NF-κB,regulation
R13342 T16398 T16401 themeOf CXCL8,expression
R13343 T16401 T16402 themeOf expression,inhibited
R13344 T16403 T16404 themeOf TNF,expression
R13345 T16404 T16405 themeOf expression,affected
R13346 T16407 T16409 themeOf IL-6,expression
R13347 T16409 T16410 themeOf expression,increased
R13348 T16410 T16411 themeOf increased,regulation
R13589 T16696 T16698 themeOf PKC,inhibitors
R13590 T16697 T16699 themeOf JNK,inhibitors
R13591 T16700 T16701 themeOf CXCL8,expression
R13592 T16701 T16702 themeOf expression,inhibited
R13593 T16704 T16706 themeOf IL-6,expression
R13594 T16707 T16708 themeOf TNF,expression
R13595 T16708 T16709 themeOf expression,affected
R13835 T16991 T16993 themeOf NF-κB,inhibition
R13836 T16992 T16994 themeOf PKC,degradation
R13837 T16997 T16998 themeOf NF-κB,activation
R13838 T17000 T17003 themeOf Bcl10,activation
R13839 T17003 T17004 themeOf activation,inhibited
R3116 T3820 T3827 causeOf NF-κB,inducing
R3118 T3821 T3828 causeOf AP-1,inducing
R3119 T3821 T3829 causeOf AP-1,inducing
R3121 T3822 T3826 themeOf secretion,inducing
R3122 T3822 T3828 themeOf secretion,inducing
R3124 T3823 T3827 themeOf secretion,inducing
R3125 T3823 T3829 themeOf secretion,inducing
R3126 T3830 T3832 themeOf AP-1,regulation
R3127 T3831 T3833 themeOf NF-κB,regulation
R3128 T3834 T3835 themeOf AP-1,activation
R3129 T3835 T3836 themeOf activation,affect
R3130 T3838 T3841 themeOf AP-1,decreased
R3131 T3839 T3842 themeOf TCR,deficient
R3132 T3840 T3843 themeOf AP-1,regulation
R3133 T3844 T3845 themeOf NF-κB,increase
R3134 T3848 T3849 themeOf NF-κB,activation

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T3929 4555-4560 Protein denotes CXCL8
T3930 4561-4568 Localization denotes release
T4708 6006-6015 Regulation denotes regulator true
T4709 6019-6024 Protein denotes CXCL8
T4710 6032-6041 Positive_regulation denotes following
T4711 6135-6145 Negative_regulation denotes inhibition
T4712 6149-6153 Protein denotes IL-6
T4713 6154-6163 Positive_regulation denotes following
T4714 6187-6197 Negative_regulation denotes inhibition
T4715 6198-6207 Positive_regulation denotes following
T4716 6255-6266 Regulation denotes involvement true
T4717 6279-6283 Protein denotes IL-6
T4718 6284-6294 Regulation denotes regulation
T4719 7821-7828 Negative_regulation denotes reduced
T4720 7829-7834 Protein denotes CXCL8
T4721 7835-7842 Localization denotes release
T4722 7889-7895 Regulation denotes effect
T4723 7899-7903 Protein denotes IL-6
T4724 8116-8131 Phosphorylation denotes phosphorylation
T4725 8116-8131 Phosphorylation denotes phosphorylation
T4726 8116-8131 Phosphorylation denotes phosphorylation
T4727 8136-8146 Positive_regulation denotes activation
T4728 8136-8146 Positive_regulation denotes activation
T4729 8136-8146 Positive_regulation denotes activation
T4730 8150-8155 Protein denotes c-Jun
T4731 8157-8162 Protein denotes c-Fos
T4732 8167-8170 Protein denotes p53
T4733 8239-8247 Positive_regulation denotes resulted
T4734 8239-8247 Positive_regulation denotes resulted
T4735 8253-8268 Negative_regulation denotes down-regulation
T4736 8253-8268 Negative_regulation denotes down-regulation
T4737 8277-8282 Protein denotes CXCL8
T4738 8287-8291 Protein denotes IL-6
T4739 8425-8432 Positive_regulation denotes induced
T4740 8425-8432 Positive_regulation denotes induced
T4741 8438-8442 Protein denotes il-6
T4742 8447-8452 Protein denotes cxcl8
T4743 8453-8457 Transcription denotes mRNA
T4744 8453-8457 Transcription denotes mRNA
T4745 8556-8563 Negative_regulation denotes reduced
T4746 8568-8572 Protein denotes il-6
T4747 8573-8583 Transcription denotes expression
T4748 8627-8632 Protein denotes cxcl8
T4749 8633-8639 Transcription denotes levels
T4750 8645-8655 Negative_regulation denotes suppressed
T4751 8690-8698 Regulation denotes remained true
T4752 8699-8707 Positive_regulation denotes elevated
T5979 9662-9671 Regulation denotes dependent
T5980 9672-9677 Protein denotes Bcl10
T5981 9678-9689 Protein_catabolism denotes degradation
T5982 9841-9845 Protein denotes IκBβ
T5983 9862-9872 Regulation denotes unaffected true
T5984 9886-9891 Protein denotes Bcl10
T5985 9960-9966 Protein denotes CARMA1
T5986 9971-9976 Protein denotes MALT1
T5987 10064-10069 Protein denotes Bcl10
T5988 10070-10080 Positive_regulation denotes activation true
T5989 10202-10207 Protein denotes Bcl10
T5990 10215-10224 Negative_regulation denotes decreased
T5991 10279-10284 Protein denotes Bcl10
T5992 10285-10303 Positive_regulation denotes returned to higher
T5993 10351-10356 Protein denotes Bcl10
T15022 1337-1347 Protein denotes luciferase
T15587 4600-4605 Protein denotes CXCL8
T15588 4607-4611 Protein denotes IL-6
T15589 4620-4630 Gene_expression denotes expression
T15590 4620-4630 Gene_expression denotes expression
T15591 4631-4640 Positive_regulation denotes following true
T15592 4631-4640 Positive_regulation denotes following true
T15593 4954-4959 Protein denotes CXCL8
T15594 4965-4969 Protein denotes IL-6
T15870 6380-6390 Protein denotes luciferase
T16152 7014-7019 Protein denotes CXCL8
T16153 7020-7030 Gene_expression denotes expression
T16154 7045-7054 Negative_regulation denotes inhibited
T16155 7122-7129 Regulation denotes altered true
T16156 7200-7209 Positive_regulation denotes induction
T16157 7217-7226 Regulation denotes regulated
T16158 7284-7288 Protein denotes IL-6
T16159 7289-7296 Localization denotes release
T16160 7312-7321 Negative_regulation denotes inhibited
T16161 7364-7374 Regulation denotes regulation
T16162 7395-7399 Protein denotes IL-6
T16163 7400-7410 Gene_expression denotes expression
T16164 7429-7438 Positive_regulation denotes increased
T16429 8911-8916 Protein denotes CXCL8
T16430 8917-8927 Gene_expression denotes expression
T16431 8932-8941 Negative_regulation denotes inhibited
T16432 8952-8961 Regulation denotes dependent
T16433 9019-9036 Negative_regulation denotes inhibitory effect
T16434 9040-9044 Protein denotes IL-6
T16435 9045-9055 Gene_expression denotes expression
T16725 10474-10483 Regulation denotes dependent
T16726 10484-10489 Protein denotes Bcl10
T16727 10490-10501 Protein_catabolism denotes degradation
T16728 10788-10793 Protein denotes Bcl10
T16729 10794-10804 Positive_regulation denotes activation
T16730 10809-10818 Negative_regulation denotes inhibited
T16731 10926-10933 Protein denotes β-actin
T4701 5795-5804 Negative_regulation denotes reduction
T4702 5808-5813 Protein denotes CXCL8
T4703 5814-5823 Positive_regulation denotes following
T4704 5855-5860 Regulation denotes alter true
T4705 5865-5870 Protein denotes CXCL8
T4706 5871-5878 Localization denotes release
T4707 5879-5888 Positive_regulation denotes following
T3906 3529-3537 Positive_regulation denotes enhanced
T3907 3538-3547 Positive_regulation denotes induction
T3908 3582-3586 Protein denotes IL-2
T3909 3588-3592 Protein denotes IL-6
T3910 3616-3621 Protein denotes CXCL8
T3911 3668-3673 Protein denotes IL-10
T3912 3679-3689 Regulation denotes unaffected true
T3913 3720-3729 Negative_regulation denotes decreased
T3914 3912-3921 Positive_regulation denotes effective
T3915 3925-3933 Positive_regulation denotes inducing
T3916 3934-3939 Protein denotes CXCL8
T3917 4030-4041 Regulation denotes involvement true
T3918 4053-4058 Protein denotes CXCL8
T3919 4059-4069 Regulation denotes regulation
T3920 4157-4162 Protein denotes CXCL8
T3921 4175-4183 Localization denotes released
T3922 4213-4217 Protein denotes IL-6
T3923 4223-4231 Localization denotes released
T3924 4322-4331 Regulation denotes regulated
T3925 4322-4331 Regulation denotes regulated
T3926 4466-4471 Protein denotes CXCL8
T3927 4504-4508 Protein denotes IL-6
T3928 4509-4516 Localization denotes release
T15302 2806-2816 Protein denotes luciferase
R3787 T4712 T4711 themeOf IL-6,inhibition
R3788 T4712 T4713 themeOf IL-6,following
R3789 T4712 T4714 themeOf IL-6,inhibition
R3790 T4712 T4715 themeOf IL-6,following
R3791 T4717 T4718 themeOf IL-6,regulation
R3792 T4718 T4716 themeOf regulation,involvement
R3793 T4720 T4721 themeOf CXCL8,release
R3794 T4721 T4719 themeOf release,reduced
R3795 T4723 T4722 themeOf IL-6,effect
R3796 T4730 T4726 themeOf c-Jun,phosphorylation
R3797 T4730 T4727 themeOf c-Jun,activation
R3798 T4731 T4724 themeOf c-Fos,phosphorylation
R3799 T4731 T4728 themeOf c-Fos,activation
R3800 T4732 T4725 themeOf p53,phosphorylation
R3801 T4732 T4729 themeOf p53,activation
R3808 T4743 T4739 themeOf mRNA,induced
R3809 T4744 T4740 themeOf mRNA,induced
R3810 T4746 T4747 themeOf il-6,expression
R3811 T4747 T4745 themeOf expression,reduced
R3812 T4748 T4749 themeOf cxcl8,levels
R3813 T4749 T4750 themeOf levels,suppressed
R3814 T4749 T4752 themeOf levels,elevated
R3815 T4752 T4751 themeOf elevated,remained
R12654 T15587 T15590 themeOf CXCL8,expression
R12655 T15588 T15589 themeOf IL-6,expression
R12656 T15589 T15591 themeOf expression,following
R12657 T15590 T15592 themeOf expression,following
R13360 T16429 T16430 themeOf CXCL8,expression
R13361 T16430 T16431 themeOf expression,inhibited
R13362 T16431 T16432 themeOf inhibited,dependent
R13363 T16434 T16435 themeOf IL-6,expression
R13364 T16435 T16433 themeOf expression,inhibitory effect
R13605 T16726 T16727 themeOf Bcl10,degradation
R13606 T16727 T16725 themeOf degradation,dependent
R13607 T16728 T16729 themeOf Bcl10,activation
R13608 T16729 T16730 themeOf activation,inhibited
R3780 T4702 T4703 themeOf CXCL8,following
R3781 T4703 T4701 themeOf following,reduction
R3782 T4705 T4706 themeOf CXCL8,release
R3783 T4706 T4707 themeOf release,following
R3784 T4707 T4704 themeOf following,alter
R3785 T4709 T4710 themeOf CXCL8,following
R3786 T4710 T4708 themeOf following,regulator
R3802 T4735 T4734 themeOf down-regulation,resulted
R3803 T4736 T4733 themeOf down-regulation,resulted
R3804 T4737 T4736 themeOf CXCL8,down-regulation
R3805 T4738 T4735 themeOf IL-6,down-regulation
R3806 T4741 T4744 themeOf il-6,mRNA
R3807 T4742 T4743 themeOf cxcl8,mRNA
R4812 T5980 T5981 themeOf Bcl10,degradation
R4813 T5981 T5979 themeOf degradation,dependent
R4814 T5982 T5983 themeOf IκBβ,unaffected
R4815 T5987 T5988 themeOf Bcl10,activation
R4816 T5989 T5990 themeOf Bcl10,decreased
R4817 T5991 T5992 themeOf Bcl10,returned to higher
R13136 T16152 T16153 themeOf CXCL8,expression
R13137 T16153 T16154 themeOf expression,inhibited
R13138 T16153 T16155 themeOf expression,altered
R13139 T16153 T16156 themeOf expression,induction
R13140 T16156 T16157 themeOf induction,regulated
R13141 T16158 T16159 themeOf IL-6,release
R13142 T16159 T16161 themeOf release,regulation
R13143 T16159 T16160 themeOf release,inhibited
R13144 T16162 T16163 themeOf IL-6,expression
R13145 T16163 T16164 themeOf expression,increased
R3166 T3907 T3906 themeOf induction,enhanced
R3167 T3910 T3907 themeOf CXCL8,induction
R3168 T3911 T3912 themeOf IL-10,unaffected
R3169 T3911 T3913 themeOf IL-10,decreased
R3170 T3915 T3914 themeOf inducing,effective
R3171 T3916 T3915 themeOf CXCL8,inducing
R3172 T3918 T3919 themeOf CXCL8,regulation
R3173 T3919 T3917 themeOf regulation,involvement
R3174 T3920 T3921 themeOf CXCL8,released
R3175 T3920 T3924 themeOf CXCL8,regulated
R3176 T3922 T3923 themeOf IL-6,released
R3177 T3922 T3925 themeOf IL-6,regulated
R3178 T3927 T3928 themeOf IL-6,release
R3179 T3929 T3930 themeOf CXCL8,release

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T3758 85-89 P05412 denotes AP-1
T3759 426-431 P26358 denotes aimed
T3760 466-470 P05412 denotes AP-1
T3761 565-569 P05412 denotes AP-1
T3762 695-699 P05412 denotes AP-1
T3763 909-913 P05412 denotes AP-1
T3764 968-972 P05412 denotes AP-1
T3765 1013-1017 P05412 denotes AP-1
T3766 1156-1160 P05412 denotes AP-1
T3767 2205-2213 Q04864 denotes relative
T4375 3582-3586 P60568 denotes IL-2
T4376 3588-3592 P05231 denotes IL-6
T4377 3594-3597 P01375 denotes TNF
T4378 3616-3621 P10145 denotes CXCL8
T4379 3668-3673 P22301 denotes IL-10
T4380 3934-3939 P10145 denotes CXCL8
T4381 3984-3988 P05412 denotes AP-1
T4382 4045-4049 P05412 denotes AP-1
T4383 4053-4058 P10145 denotes CXCL8
T4384 4157-4162 P10145 denotes CXCL8
T4385 4205-4208 P01375 denotes TNF
T4386 4213-4217 P05231 denotes IL-6
T4387 4443-4447 P05412 denotes AP-1
T4388 4466-4471 P10145 denotes CXCL8
T4389 4496-4499 P01375 denotes TNF
T4390 4504-4508 P05231 denotes IL-6
T4391 4555-4560 P10145 denotes CXCL8
T4392 4573-4577 P05412 denotes AP-1
T5511 5448-5452 P05412 denotes AP-1
T5512 5705-5709 P05412 denotes AP-1
T5513 5808-5813 P10145 denotes CXCL8
T5514 5865-5870 P10145 denotes CXCL8
T5515 5941-5944 P01375 denotes TNF
T5516 6019-6024 P10145 denotes CXCL8
T5517 6028-6031 P01375 denotes TNF
T5518 6149-6153 P05231 denotes IL-6
T5519 6279-6283 P05231 denotes IL-6
T5520 7623-7627 P05412 denotes AP-1
T5521 7829-7834 P10145 denotes CXCL8
T5522 7899-7903 P05231 denotes IL-6
T5523 7908-7911 P01375 denotes TNF
T5524 8150-8155 P05412 denotes c-Jun
T5525 8152-8155 P05412 denotes Jun
T5526 8167-8170 P04637 denotes p53
T5527 8277-8282 P10145 denotes CXCL8
T5528 8287-8291 P05231 denotes IL-6
T5529 8331-8334 P01375 denotes TNF
T5530 8438-8442 P05231 denotes il-6
T5531 8447-8452 P10145 denotes cxcl8
T5532 8568-8572 P05231 denotes il-6
T5533 8627-8632 P10145 denotes cxcl8
T6289 9672-9677 O95999 denotes Bcl10
T6290 9841-9845 Q15653 denotes IκBβ
T6291 9886-9891 O95999 denotes Bcl10
T6292 9960-9966 Q9BXL7 denotes CARMA1
T6293 9971-9976 Q9UDY8 denotes MALT1
T6294 10064-10069 O95999 denotes Bcl10
T6295 10202-10207 O95999 denotes Bcl10
T6296 10279-10284 O95999 denotes Bcl10
T6297 10351-10356 O95999 denotes Bcl10
T15261 1229-1233 P05412 denotes AP-1
T15262 1337-1347 P08659 denotes luciferase
T15263 1381-1385 P05412 denotes AP-1
T15264 1419-1423 P05412 denotes AP-1
T15265 1488-1492 P05412 denotes AP-1
T15266 1527-1531 P05412 denotes AP-1
T15267 1713-1717 P05412 denotes AP-1
T15532 2806-2816 P08659 denotes luciferase
T15803 4600-4605 P10145 denotes CXCL8
T15804 4607-4611 P05231 denotes IL-6
T15805 4616-4619 P01375 denotes TNF
T15806 4954-4959 P10145 denotes CXCL8
T15807 4965-4969 P05231 denotes IL-6
T15808 4978-4981 P01375 denotes TNF
T16100 6380-6390 P08659 denotes luciferase
T16101 6436-6440 P05412 denotes AP-1
T16102 6663-6667 P05412 denotes AP-1
T16311 7014-7019 P10145 denotes CXCL8
T16312 7230-7234 P05412 denotes AP-1
T16313 7240-7243 P01375 denotes TNF
T16314 7284-7288 P05231 denotes IL-6
T16315 7395-7399 P05231 denotes IL-6
T16630 8911-8916 P10145 denotes CXCL8
T16631 9040-9044 P05231 denotes IL-6
T16632 9076-9079 P01375 denotes TNF
T16937 10484-10489 O95999 denotes Bcl10
T16938 10788-10793 O95999 denotes Bcl10
T16939 10926-10933 P60709 denotes β-actin

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T3885 3529-3537 Positive_regulation denotes enhanced
T3886 3538-3547 Positive_regulation denotes induction
T3887 3582-3586 Protein denotes IL-2 true
T3888 3588-3592 Protein denotes IL-6
T3889 3616-3621 Protein denotes CXCL8
T3890 3668-3673 Protein denotes IL-10
T3891 3720-3729 Negative_regulation denotes decreased true
T3892 3934-3939 Protein denotes CXCL8
T3893 4053-4058 Protein denotes CXCL8
T3894 4059-4069 Regulation denotes regulation
T3895 4157-4162 Protein denotes CXCL8
T3896 4175-4183 Localization denotes released
T3897 4213-4217 Protein denotes IL-6
T3898 4223-4231 Localization denotes released
T3899 4466-4471 Protein denotes CXCL8
T3900 4483-4491 Positive_regulation denotes preceded
T3901 4504-4508 Protein denotes IL-6
T3902 4509-4516 Localization denotes release
T3903 4535-4546 Binding denotes association
T3904 4555-4560 Protein denotes CXCL8
T3905 4561-4568 Localization denotes release
T4657 5774-5782 Positive_regulation denotes resulted
T4658 5795-5804 Negative_regulation denotes reduction
T4659 5808-5813 Protein denotes CXCL8 true
T4660 5814-5823 Positive_regulation denotes following
T4661 5855-5860 Regulation denotes alter
T4662 5865-5870 Protein denotes CXCL8 true
T4663 5871-5878 Localization denotes release
T4664 5879-5888 Positive_regulation denotes following
T4665 5934-5940 Regulation denotes affect
T4666 5945-5955 Gene_expression denotes expression
T4667 6006-6015 Regulation denotes regulator
T4668 6019-6024 Protein denotes CXCL8 true
T4669 6032-6041 Positive_regulation denotes following
T4670 6112-6120 Positive_regulation denotes resulted
T4671 6135-6145 Negative_regulation denotes inhibition
T4672 6149-6153 Protein denotes IL-6
T4673 6154-6163 Positive_regulation denotes following
T4674 6255-6266 Regulation denotes involvement
T4675 6279-6283 Protein denotes IL-6
T4676 6284-6294 Regulation denotes regulation
T4677 7821-7828 Negative_regulation denotes reduced
T4678 7829-7834 Protein denotes CXCL8
T4679 7835-7842 Localization denotes release
T4680 7889-7895 Regulation denotes effect
T4681 7899-7903 Protein denotes IL-6
T4682 8116-8131 Phosphorylation denotes phosphorylation
T4683 8136-8146 Positive_regulation denotes activation
T4684 8150-8155 Protein denotes c-Jun
T4685 8157-8162 Protein denotes c-Fos
T4686 8167-8170 Protein denotes p53
T4687 8239-8247 Positive_regulation denotes resulted
T4688 8253-8268 Negative_regulation denotes down-regulation
T4689 8277-8282 Protein denotes CXCL8
T4690 8287-8291 Protein denotes IL-6
T4691 8335-8345 Gene_expression denotes expression true
T4692 8425-8432 Positive_regulation denotes induced
T4693 8438-8442 Protein denotes il-6
T4694 8447-8452 Protein denotes cxcl8
T4695 8556-8563 Negative_regulation denotes reduced
T4696 8568-8572 Protein denotes il-6
T4697 8573-8583 Gene_expression denotes expression
T4698 8627-8632 Protein denotes cxcl8
T4699 8645-8655 Negative_regulation denotes suppressed
T4700 8699-8707 Positive_regulation denotes elevated
T5963 9662-9671 Regulation denotes dependent
T5964 9672-9677 Protein denotes Bcl10
T5965 9678-9689 Protein_catabolism denotes degradation true
T5966 9841-9845 Protein denotes IκBβ true
T5967 9886-9891 Protein denotes Bcl10
T5968 9960-9966 Protein denotes CARMA1
T5969 9971-9976 Protein denotes MALT1
T5970 10064-10069 Protein denotes Bcl10
T5971 10070-10080 Positive_regulation denotes activation
T5972 10202-10207 Protein denotes Bcl10
T5973 10215-10224 Negative_regulation denotes decreased
T5974 10225-10234 Positive_regulation denotes following
T5975 10279-10284 Protein denotes Bcl10
T5976 10285-10296 Positive_regulation denotes returned to
T5977 10297-10303 Positive_regulation denotes higher
T5978 10351-10356 Protein denotes Bcl10
T15021 1337-1347 Protein denotes luciferase
T15301 2806-2816 Protein denotes luciferase
T15581 4600-4605 Protein denotes CXCL8
T15582 4607-4611 Protein denotes IL-6
T15583 4620-4630 Gene_expression denotes expression true
T15584 4631-4640 Positive_regulation denotes following true
T15585 4954-4959 Protein denotes CXCL8
T15586 4965-4969 Protein denotes IL-6
T15869 6380-6390 Protein denotes luciferase
T16139 7014-7019 Protein denotes CXCL8
T16140 7020-7030 Gene_expression denotes expression
T16141 7045-7054 Negative_regulation denotes inhibited true
T16142 7244-7254 Gene_expression denotes expression
T16143 7263-7271 Regulation denotes affected
T16144 7284-7288 Protein denotes IL-6
T16145 7289-7296 Localization denotes release
T16146 7312-7321 Negative_regulation denotes inhibited
T16147 7329-7338 Positive_regulation denotes following
T16148 7364-7374 Regulation denotes regulation
T16149 7395-7399 Protein denotes IL-6
T16150 7400-7410 Gene_expression denotes expression
T16151 7429-7438 Positive_regulation denotes increased
T16419 8911-8916 Protein denotes CXCL8
T16420 8917-8927 Gene_expression denotes expression
T16421 8932-8941 Negative_regulation denotes inhibited
T16422 8952-8961 Regulation denotes dependent
T16423 9019-9029 Negative_regulation denotes inhibitory
T16424 9030-9036 Regulation denotes effect
T16425 9040-9044 Protein denotes IL-6
T16426 9045-9055 Gene_expression denotes expression
T16427 9080-9090 Gene_expression denotes expression
T16428 9099-9107 Regulation denotes affected
T16717 10474-10483 Regulation denotes dependent
T16718 10484-10489 Protein denotes Bcl10
T16719 10490-10501 Protein_catabolism denotes degradation
T16720 10788-10793 Protein denotes Bcl10
T16721 10794-10804 Positive_regulation denotes activation
T16722 10809-10818 Negative_regulation denotes inhibited
T16723 10819-10828 Positive_regulation denotes following
T16724 10926-10933 Protein denotes β-actin
R3155 T3886 T3885 themeOf induction,enhanced
R3156 T3887 T3886 themeOf IL-2,induction
R3157 T3888 T3886 themeOf IL-6,induction
R3158 T3889 T3886 themeOf CXCL8,induction
R3159 T3890 T3891 themeOf IL-10,decreased
R3160 T3893 T3894 themeOf CXCL8,regulation
R3161 T3895 T3896 themeOf CXCL8,released
R3162 T3897 T3898 themeOf IL-6,released
R3163 T3901 T3902 themeOf IL-6,release
R3164 T3902 T3900 themeOf release,preceded
R3165 T3904 T3905 themeOf CXCL8,release
R3750 T4658 T4657 themeOf reduction,resulted
R3751 T4659 T4658 themeOf CXCL8,reduction
R3752 T4662 T4663 themeOf CXCL8,release
R3753 T4663 T4661 themeOf release,alter
R3754 T4663 T4664 themeOf release,following
R3755 T4666 T4665 themeOf expression,affect
R3756 T4668 T4669 themeOf CXCL8,following
R3757 T4669 T4667 themeOf following,regulator
R3758 T4671 T4670 themeOf inhibition,resulted
R3759 T4672 T4671 themeOf IL-6,inhibition
R3760 T4675 T4676 themeOf IL-6,regulation
R3761 T4676 T4674 themeOf regulation,involvement
R3762 T4678 T4679 themeOf CXCL8,release
R3763 T4679 T4677 themeOf release,reduced
R3764 T4681 T4680 themeOf IL-6,effect
R3765 T4684 T4683 themeOf c-Jun,activation
R3766 T4684 T4682 themeOf c-Jun,phosphorylation
R3767 T4685 T4683 themeOf c-Fos,activation
R3768 T4685 T4682 themeOf c-Fos,phosphorylation
R3769 T4686 T4682 themeOf p53,phosphorylation
R3770 T4686 T4683 themeOf p53,activation
R3771 T4688 T4687 themeOf down-regulation,resulted
R3772 T4689 T4688 themeOf CXCL8,down-regulation
R3773 T4690 T4688 themeOf IL-6,down-regulation
R3774 T4693 T4692 themeOf il-6,induced
R3775 T4694 T4692 themeOf cxcl8,induced
R3776 T4696 T4697 themeOf il-6,expression
R3777 T4697 T4695 themeOf expression,reduced
R3778 T4698 T4699 themeOf cxcl8,suppressed
R3779 T4698 T4700 themeOf cxcl8,elevated
R4807 T5964 T5965 themeOf Bcl10,degradation
R4808 T5965 T5963 themeOf degradation,dependent
R4809 T5970 T5971 themeOf Bcl10,activation
R4810 T5972 T5973 themeOf Bcl10,decreased
R4811 T5975 T5977 themeOf Bcl10,higher
R12651 T15581 T15583 themeOf CXCL8,expression
R12652 T15582 T15583 themeOf IL-6,expression
R12653 T15583 T15584 themeOf expression,following
R13126 T16139 T16140 themeOf CXCL8,expression
R13127 T16140 T16141 themeOf expression,inhibited
R13128 T16142 T16143 themeOf expression,affected
R13129 T16144 T16145 themeOf IL-6,release
R13130 T16145 T16146 themeOf release,inhibited
R13131 T16145 T16148 themeOf release,regulation
R13132 T16145 T16147 themeOf release,following
R13133 T16149 T16150 themeOf IL-6,expression
R13134 T16150 T16151 themeOf expression,increased
R13135 T16150 T16148 themeOf expression,regulation
R13354 T16419 T16420 themeOf CXCL8,expression
R13355 T16420 T16421 themeOf expression,inhibited
R13356 T16421 T16422 themeOf inhibited,dependent
R13357 T16425 T16426 themeOf IL-6,expression
R13358 T16426 T16424 themeOf expression,effect
R13359 T16427 T16428 themeOf expression,affected
R13600 T16718 T16719 themeOf Bcl10,degradation
R13601 T16719 T16717 themeOf degradation,dependent
R13602 T16720 T16721 themeOf Bcl10,activation
R13603 T16721 T16723 themeOf activation,following
R13604 T16721 T16722 themeOf activation,inhibited