
PMC:2889865 / 33-493
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T542 | 0-2 | IN | denotes | by |
T543 | 3-8 | NN | denotes | NF-κB |
T544 | 9-12 | CC | denotes | and |
T545 | 13-17 | NN | denotes | AP-1 |
T546 | 18-20 | IN | denotes | in |
T547 | 21-27 | NN | denotes | Jurkat |
T548 | 28-35 | NN | denotes | T-cells |
T549 | 47-57 | NN | denotes | Background |
T550 | 58-67 | NN | denotes | Activator |
T551 | 68-75 | NN | denotes | protein |
T552 | 76-77 | -LRB- | denotes | ( |
T553 | 77-79 | NN | denotes | AP |
T554 | 79-80 | -RRB- | denotes | ) |
T555 | 80-82 | CD | denotes | -1 |
T556 | 83-86 | CC | denotes | and |
T557 | 87-94 | JJ | denotes | nuclear |
T558 | 95-101 | NN | denotes | factor |
T559 | 102-103 | -LRB- | denotes | ( |
T560 | 103-105 | NN | denotes | NF |
T561 | 105-106 | -RRB- | denotes | ) |
T562 | 106-109 | NN | denotes | -κB |
T563 | 110-117 | RB | denotes | largely |
T564 | 118-125 | VB | denotes | control |
T565 | 126-132 | NN | denotes | T-cell |
T566 | 133-143 | NN | denotes | activation |
T567 | 143-144 | -COMMA- | denotes | , |
T568 | 145-154 | VB | denotes | following |
T569 | 155-162 | NN | denotes | binding |
T570 | 163-165 | IN | denotes | of |
T571 | 166-173 | JJ | denotes | foreign |
T572 | 174-182 | NN | denotes | antigens |
T573 | 183-185 | TO | denotes | to |
T574 | 186-189 | DT | denotes | the |
T575 | 190-196 | NN | denotes | T-cell |
T576 | 197-205 | NN | denotes | receptor |
T577 | 206-213 | VB | denotes | leading |
T578 | 214-216 | TO | denotes | to |
T579 | 217-225 | NN | denotes | cytokine |
T580 | 226-235 | NN | denotes | secretion |
T581 | 237-245 | JJ | denotes | Elevated |
T582 | 246-252 | NN | denotes | levels |
T583 | 253-255 | IN | denotes | of |
T584 | 256-272 | JJ | denotes | pro-inflammatory |
T585 | 273-282 | NN | denotes | cytokines |
T586 | 283-286 | CC | denotes | and |
T587 | 287-297 | NN | denotes | chemokines |
T588 | 298-302 | JJ | denotes | such |
T589 | 303-305 | IN | denotes | as |
T590 | 306-309 | NN | denotes | TNF |
T591 | 309-310 | -COMMA- | denotes | , |
T592 | 311-315 | NN | denotes | IL-6 |
T593 | 316-319 | CC | denotes | and |
T594 | 320-325 | NN | denotes | CXCL8 |
T595 | 326-329 | VB | denotes | are |
T596 | 330-340 | VB | denotes | associated |
T597 | 341-345 | IN | denotes | with |
T598 | 346-353 | JJ | denotes | several |
T599 | 354-359 | JJ | denotes | human |
T600 | 360-368 | NN | denotes | diseases |
T601 | 369-378 | VB | denotes | including |
T602 | 379-385 | JJ | denotes | cystic |
T603 | 386-394 | NN | denotes | fibrosis |
T604 | 394-395 | -COMMA- | denotes | , |
T605 | 396-405 | JJ | denotes | pulmonary |
T606 | 406-414 | NN | denotes | fibrosis |
T607 | 415-418 | CC | denotes | and |
T608 | 419-423 | NN | denotes | AIDS |
T609 | 425-428 | DT | denotes | The |
T610 | 429-432 | NN | denotes | aim |
T611 | 433-435 | IN | denotes | of |
T612 | 436-440 | DT | denotes | this |
T613 | 441-446 | NN | denotes | study |
T614 | 447-450 | VB | denotes | was |
T615 | 451-453 | TO | denotes | to |
R432 | T543 | T544 | arg1Of | NF-κB,and |
R433 | T544 | T542 | arg2Of | and,by |
R434 | T545 | T544 | arg2Of | AP-1,and |
R435 | T548 | T546 | arg2Of | T-cells,in |
R436 | T548 | T547 | arg1Of | T-cells,Jurkat |
R437 | T551 | T550 | arg1Of | protein,Activator |
R438 | T551 | T552 | arg1Of | protein,( |
R439 | T551 | T555 | arg1Of | protein,-1 |
R440 | T551 | T556 | arg1Of | protein,and |
R441 | T553 | T552 | arg2Of | AP,( |
R442 | T554 | T552 | arg3Of | ),( |
R443 | T556 | T564 | arg1Of | and,control |
R444 | T560 | T559 | arg2Of | NF,( |
R445 | T561 | T559 | arg3Of | ),( |
R446 | T562 | T556 | arg2Of | -κB,and |
R447 | T562 | T557 | arg1Of | -κB,nuclear |
R448 | T562 | T558 | arg1Of | -κB,factor |
R449 | T562 | T559 | arg1Of | -κB,( |
R450 | T564 | T563 | arg1Of | control,largely |
R451 | T564 | T567 | arg1Of | control,"," |
R452 | T564 | T568 | arg1Of | control,following |
R453 | T566 | T564 | arg2Of | activation,control |
R454 | T566 | T565 | arg1Of | activation,T-cell |
R455 | T569 | T568 | arg2Of | binding,following |
R456 | T569 | T570 | arg1Of | binding,of |
R457 | T569 | T573 | arg1Of | binding,to |
R458 | T572 | T570 | arg2Of | antigens,of |
R459 | T572 | T571 | arg1Of | antigens,foreign |
R460 | T576 | T573 | arg2Of | receptor,to |
R461 | T576 | T574 | arg1Of | receptor,the |
R462 | T576 | T575 | arg1Of | receptor,T-cell |
R463 | T576 | T577 | arg1Of | receptor,leading |
R464 | T577 | T578 | arg1Of | leading,to |
R465 | T580 | T578 | arg2Of | secretion,to |
R466 | T580 | T579 | arg1Of | secretion,cytokine |
R467 | T582 | T581 | arg1Of | levels,Elevated |
R468 | T582 | T583 | arg1Of | levels,of |
R469 | T582 | T595 | arg1Of | levels,are |
R470 | T582 | T596 | arg2Of | levels,associated |
R471 | T585 | T586 | arg1Of | cytokines,and |
R472 | T586 | T583 | arg2Of | and,of |
R473 | T586 | T584 | arg1Of | and,pro-inflammatory |
R474 | T586 | T589 | arg1Of | and,as |
R475 | T587 | T586 | arg2Of | chemokines,and |
R476 | T589 | T588 | arg1Of | as,such |
R477 | T590 | T591 | arg1Of | TNF,"," |
R478 | T591 | T593 | arg1Of | ",",and |
R479 | T592 | T591 | arg2Of | IL-6,"," |
R480 | T593 | T589 | arg2Of | and,as |
R481 | T594 | T593 | arg2Of | CXCL8,and |
R482 | T596 | T595 | arg2Of | associated,are |
R483 | T596 | T597 | arg1Of | associated,with |
R484 | T600 | T597 | arg2Of | diseases,with |
R485 | T600 | T598 | arg1Of | diseases,several |
R486 | T600 | T599 | arg1Of | diseases,human |
R487 | T600 | T601 | arg1Of | diseases,including |
R488 | T603 | T602 | arg1Of | fibrosis,cystic |
R489 | T603 | T604 | arg1Of | fibrosis,"," |
R490 | T604 | T607 | arg1Of | ",",and |
R491 | T606 | T604 | arg2Of | fibrosis,"," |
R492 | T606 | T605 | arg1Of | fibrosis,pulmonary |
R493 | T607 | T601 | arg2Of | and,including |
R494 | T608 | T607 | arg2Of | AIDS,and |
R495 | T610 | T609 | arg1Of | aim,The |
R496 | T610 | T611 | arg1Of | aim,of |
R497 | T610 | T614 | arg1Of | aim,was |
R498 | T613 | T611 | arg2Of | study,of |
R499 | T613 | T612 | arg1Of | study,this |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T166 | 143-144 | , | denotes | , |
T167 | 145-154 | VBG | denotes | following |
T168 | 155-162 | JJ | denotes | binding |
T169 | 163-165 | IN | denotes | of |
T170 | 166-173 | JJ | denotes | foreign |
T171 | 174-182 | NNS | denotes | antigens |
T172 | 183-185 | TO | denotes | to |
T173 | 186-189 | DT | denotes | the |
T174 | 190-196 | NN | denotes | T-cell |
T175 | 197-205 | NN | denotes | receptor |
T176 | 206-213 | VBG | denotes | leading |
T177 | 214-216 | TO | denotes | to |
T178 | 217-225 | VB | denotes | cytokine |
T179 | 226-235 | NN | denotes | secretion |
T180 | 235-236 | . | denotes | . |
T181 | 237-245 | JJ | denotes | Elevated |
T182 | 246-252 | NNS | denotes | levels |
T183 | 253-255 | IN | denotes | of |
T184 | 256-272 | JJ | denotes | pro-inflammatory |
T185 | 273-282 | NNS | denotes | cytokines |
T186 | 283-286 | CC | denotes | and |
T187 | 287-297 | NNS | denotes | chemokines |
T188 | 298-302 | JJ | denotes | such |
T189 | 303-305 | IN | denotes | as |
T190 | 306-309 | NNP | denotes | TNF |
T191 | 309-310 | , | denotes | , |
T192 | 311-315 | NNP | denotes | IL-6 |
T193 | 316-319 | CC | denotes | and |
T194 | 320-325 | NNP | denotes | CXCL8 |
T195 | 326-329 | VBP | denotes | are |
T196 | 330-340 | VBN | denotes | associated |
T197 | 341-345 | IN | denotes | with |
T198 | 346-353 | JJ | denotes | several |
T199 | 354-359 | JJ | denotes | human |
T200 | 360-368 | NNS | denotes | diseases |
T201 | 369-378 | VBG | denotes | including |
T202 | 379-385 | JJ | denotes | cystic |
T203 | 386-394 | NN | denotes | fibrosis |
T204 | 394-395 | , | denotes | , |
T205 | 396-405 | JJ | denotes | pulmonary |
T206 | 406-414 | NN | denotes | fibrosis |
T207 | 415-418 | CC | denotes | and |
T208 | 419-423 | NNP | denotes | AIDS |
T209 | 423-424 | . | denotes | . |
T210 | 425-428 | DT | denotes | The |
T211 | 429-432 | NN | denotes | aim |
T212 | 433-435 | IN | denotes | of |
T213 | 436-440 | DT | denotes | this |
T214 | 441-446 | NN | denotes | study |
T215 | 447-450 | VBD | denotes | was |
T216 | 451-453 | TO | denotes | to |
T140 | 0-2 | IN | denotes | by |
T141 | 3-8 | NNP | denotes | NF-κB |
T142 | 9-12 | CC | denotes | and |
T143 | 13-17 | NNP | denotes | AP-1 |
T144 | 18-20 | IN | denotes | in |
T145 | 21-27 | NNP | denotes | Jurkat |
T146 | 28-35 | NNP | denotes | T-cells |
T147 | 47-57 | NNP | denotes | Background |
T148 | 58-67 | NNP | denotes | Activator |
T149 | 68-75 | NN | denotes | protein |
T150 | 76-77 | -LRB- | denotes | ( |
T151 | 77-79 | NNP | denotes | AP |
T152 | 79-80 | -RRB- | denotes | ) |
T153 | 80-82 | CD | denotes | -1 |
T154 | 83-86 | CC | denotes | and |
T155 | 87-94 | JJ | denotes | nuclear |
T156 | 95-101 | NN | denotes | factor |
T157 | 102-103 | -LRB- | denotes | ( |
T158 | 103-105 | NNP | denotes | NF |
T159 | 105-106 | -RRB- | denotes | ) |
T160 | 106-107 | : | denotes | - |
T161 | 107-109 | NN | denotes | κB |
T162 | 110-117 | RB | denotes | largely |
T163 | 118-125 | JJ | denotes | control |
T164 | 126-132 | NNP | denotes | T-cell |
T165 | 133-143 | NN | denotes | activation |
R58 | T168 | T167 | pobj | binding,following |
R59 | T169 | T168 | prep | of,binding |
R60 | T170 | T171 | amod | foreign,antigens |
R61 | T171 | T169 | pobj | antigens,of |
R62 | T172 | T168 | prep | to,binding |
R63 | T173 | T175 | det | the,receptor |
R56 | T166 | T165 | punct | ",",activation |
R64 | T174 | T175 | compound | T-cell,receptor |
R65 | T175 | T172 | pobj | receptor,to |
R66 | T176 | T175 | acl | leading,receptor |
R67 | T177 | T176 | prep | to,leading |
R68 | T178 | T179 | amod | cytokine,secretion |
R69 | T179 | T177 | pobj | secretion,to |
R71 | T181 | T182 | amod | Elevated,levels |
R72 | T182 | T196 | nsubjpass | levels,associated |
R73 | T183 | T182 | prep | of,levels |
R74 | T184 | T185 | amod | pro-inflammatory,cytokines |
R75 | T185 | T183 | pobj | cytokines,of |
R76 | T186 | T185 | cc | and,cytokines |
R77 | T187 | T185 | conj | chemokines,cytokines |
R78 | T188 | T189 | amod | such,as |
R79 | T189 | T187 | prep | as,chemokines |
R80 | T190 | T189 | pobj | TNF,as |
R81 | T191 | T190 | punct | ",",TNF |
R82 | T192 | T190 | conj | IL-6,TNF |
R83 | T193 | T192 | cc | and,IL-6 |
R84 | T194 | T192 | conj | CXCL8,IL-6 |
R85 | T195 | T196 | auxpass | are,associated |
R86 | T196 | T196 | ROOT | associated,associated |
R87 | T197 | T196 | prep | with,associated |
R88 | T198 | T200 | amod | several,diseases |
R89 | T199 | T200 | amod | human,diseases |
R90 | T200 | T197 | pobj | diseases,with |
R91 | T201 | T200 | prep | including,diseases |
R92 | T202 | T203 | amod | cystic,fibrosis |
R93 | T203 | T201 | pobj | fibrosis,including |
R94 | T204 | T203 | punct | ",",fibrosis |
R95 | T205 | T206 | amod | pulmonary,fibrosis |
R96 | T206 | T203 | conj | fibrosis,fibrosis |
R97 | T207 | T206 | cc | and,fibrosis |
R98 | T208 | T206 | conj | AIDS,fibrosis |
R99 | T209 | T196 | punct | .,associated |
R100 | T210 | T211 | det | The,aim |
R101 | T211 | T215 | nsubj | aim,was |
R102 | T212 | T211 | prep | of,aim |
R103 | T213 | T214 | det | this,study |
R104 | T214 | T212 | pobj | study,of |
R105 | T215 | T215 | ROOT | was,was |
R962 | T142 | T141 | cc | and,NF-κB |
R963 | T143 | T141 | conj | AP-1,NF-κB |
R965 | T145 | T149 | compound | Jurkat,protein |
R966 | T146 | T149 | compound | T-cells,protein |
R967 | T147 | T148 | compound | Background,Activator |
R968 | T148 | T149 | compound | Activator,protein |
R969 | T149 | T144 | pobj | protein,in |
R970 | T150 | T151 | punct | (,AP |
R971 | T151 | T149 | appos | AP,protein |
R972 | T152 | T151 | punct | ),AP |
R973 | T153 | T151 | nummod | -1,AP |
R974 | T154 | T149 | cc | and,protein |
R975 | T155 | T156 | amod | nuclear,factor |
R976 | T156 | T149 | conj | factor,protein |
R977 | T157 | T158 | punct | (,NF |
R978 | T158 | T156 | appos | NF,factor |
R979 | T159 | T158 | punct | ),NF |
R980 | T160 | T161 | punct | -,κB |
R981 | T161 | T165 | amod | κB,activation |
R982 | T162 | T163 | advmod | largely,control |
R983 | T163 | T165 | amod | control,activation |
R984 | T164 | T165 | compound | T-cell,activation |
R961 | T141 | T140 | pobj | NF-κB,by |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T978 | 126-143 | http://purl.obolibrary.org/obo/GO_0051132 | denotes | T-cell activation |
T979 | 126-143 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T-cell activation |
T980 | 126-143 | http://purl.obolibrary.org/obo/GO_0050798 | denotes | T-cell activation |
T981 | 126-143 | http://purl.obolibrary.org/obo/GO_0050863 | denotes | T-cell activation |
T982 | 126-143 | http://purl.obolibrary.org/obo/GO_1903905 | denotes | T-cell activation |
T983 | 128-143 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
T984 | 217-235 | http://purl.obolibrary.org/obo/GO_0050663 | denotes | cytokine secretion |
T985 | 226-235 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1003 | 155-162 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T1004 | 190-205 | http://purl.obolibrary.org/obo/GO_0042608 | denotes | T-cell receptor |
T1005 | 311-315 | http://purl.obolibrary.org/obo/GO_0005138 | denotes | IL-6 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1018 | 30-35 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T1021 | 190-205 | http://purl.obolibrary.org/obo/GO_0042101 | denotes | T-cell receptor |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T120 | 47-57 | Sentence | denotes | Background |
T121 | 58-236 | Sentence | denotes | Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion. |
T122 | 237-424 | Sentence | denotes | Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with several human diseases including cystic fibrosis, pulmonary fibrosis and AIDS. |
T2 | 38-46 | Sentence | denotes | Abstract |
T3 | 47-57 | Sentence | denotes | Background |
T4 | 58-236 | Sentence | denotes | Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion. |
T5 | 237-424 | Sentence | denotes | Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with several human diseases including cystic fibrosis, pulmonary fibrosis and AIDS. |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1002 | 379-405 | http://purl.bioontology.org/ontology/ICD10/E84.0 | denotes | cystic fibrosis, pulmonary |
T1000 | 379-394 | http://purl.bioontology.org/ontology/ICD10/E84 | denotes | cystic fibrosis |
T1001 | 379-394 | http://purl.bioontology.org/ontology/ICD10/E84.9 | denotes | cystic fibrosis |
events-check-again
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1212 | 311-315 | Protein | denotes | IL-6 |
T1213 | 320-325 | Protein | denotes | CXCL8 |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1252 | 3-8 | Protein | denotes | NF-κB |
T1253 | 13-17 | Protein | denotes | AP-1 |
T1254 | 107-109 | Protein | denotes | κB |
T1255 | 155-162 | Binding | denotes | binding |
T1256 | 306-309 | Protein | denotes | TNF |
T1257 | 311-315 | Protein | denotes | IL-6 |
T1258 | 320-325 | Protein | denotes | CXCL8 |
R898 | T1254 | T1255 | themeOf | κB,binding |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T79 | 311-315 | Protein | denotes | IL-6 |
T80 | 320-325 | Protein | denotes | CXCL8 |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T928 | 429-432 | P26358 | denotes | aim |
T924 | 13-17 | P05412 | denotes | AP-1 |
T925 | 306-309 | P01375 | denotes | TNF |
T926 | 311-315 | P05231 | denotes | IL-6 |
T927 | 320-325 | P10145 | denotes | CXCL8 |
test2
Id | Subject | Object | Predicate | Lexical cue | Negation |
---|---|---|---|---|---|
T41 | 311-315 | Protein | denotes | IL-6 | true |
T42 | 320-325 | Protein | denotes | CXCL8 | |
T43 | 330-340 | Binding | denotes | associated | true |
R22 | T41 | T43 | themeOf | IL-6,associated | |
R23 | T42 | T43 | themeOf | CXCL8,associated |