PMC:2889865 / 33-493
Annnotations
pmc-enju-pas
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T542 | 0-2 | IN | denotes | by |
| T543 | 3-8 | NN | denotes | NF-κB |
| T544 | 9-12 | CC | denotes | and |
| T545 | 13-17 | NN | denotes | AP-1 |
| T546 | 18-20 | IN | denotes | in |
| T547 | 21-27 | NN | denotes | Jurkat |
| T548 | 28-35 | NN | denotes | T-cells |
| T549 | 47-57 | NN | denotes | Background |
| T550 | 58-67 | NN | denotes | Activator |
| T551 | 68-75 | NN | denotes | protein |
| T552 | 76-77 | -LRB- | denotes | ( |
| T553 | 77-79 | NN | denotes | AP |
| T554 | 79-80 | -RRB- | denotes | ) |
| T555 | 80-82 | CD | denotes | -1 |
| T556 | 83-86 | CC | denotes | and |
| T557 | 87-94 | JJ | denotes | nuclear |
| T558 | 95-101 | NN | denotes | factor |
| T559 | 102-103 | -LRB- | denotes | ( |
| T560 | 103-105 | NN | denotes | NF |
| T561 | 105-106 | -RRB- | denotes | ) |
| T562 | 106-109 | NN | denotes | -κB |
| T563 | 110-117 | RB | denotes | largely |
| T564 | 118-125 | VB | denotes | control |
| T565 | 126-132 | NN | denotes | T-cell |
| T566 | 133-143 | NN | denotes | activation |
| T567 | 143-144 | -COMMA- | denotes | , |
| T568 | 145-154 | VB | denotes | following |
| T569 | 155-162 | NN | denotes | binding |
| T570 | 163-165 | IN | denotes | of |
| T571 | 166-173 | JJ | denotes | foreign |
| T572 | 174-182 | NN | denotes | antigens |
| T573 | 183-185 | TO | denotes | to |
| T574 | 186-189 | DT | denotes | the |
| T575 | 190-196 | NN | denotes | T-cell |
| T576 | 197-205 | NN | denotes | receptor |
| T577 | 206-213 | VB | denotes | leading |
| T578 | 214-216 | TO | denotes | to |
| T579 | 217-225 | NN | denotes | cytokine |
| T580 | 226-235 | NN | denotes | secretion |
| T581 | 237-245 | JJ | denotes | Elevated |
| T582 | 246-252 | NN | denotes | levels |
| T583 | 253-255 | IN | denotes | of |
| T584 | 256-272 | JJ | denotes | pro-inflammatory |
| T585 | 273-282 | NN | denotes | cytokines |
| T586 | 283-286 | CC | denotes | and |
| T587 | 287-297 | NN | denotes | chemokines |
| T588 | 298-302 | JJ | denotes | such |
| T589 | 303-305 | IN | denotes | as |
| T590 | 306-309 | NN | denotes | TNF |
| T591 | 309-310 | -COMMA- | denotes | , |
| T592 | 311-315 | NN | denotes | IL-6 |
| T593 | 316-319 | CC | denotes | and |
| T594 | 320-325 | NN | denotes | CXCL8 |
| T595 | 326-329 | VB | denotes | are |
| T596 | 330-340 | VB | denotes | associated |
| T597 | 341-345 | IN | denotes | with |
| T598 | 346-353 | JJ | denotes | several |
| T599 | 354-359 | JJ | denotes | human |
| T600 | 360-368 | NN | denotes | diseases |
| T601 | 369-378 | VB | denotes | including |
| T602 | 379-385 | JJ | denotes | cystic |
| T603 | 386-394 | NN | denotes | fibrosis |
| T604 | 394-395 | -COMMA- | denotes | , |
| T605 | 396-405 | JJ | denotes | pulmonary |
| T606 | 406-414 | NN | denotes | fibrosis |
| T607 | 415-418 | CC | denotes | and |
| T608 | 419-423 | NN | denotes | AIDS |
| T609 | 425-428 | DT | denotes | The |
| T610 | 429-432 | NN | denotes | aim |
| T611 | 433-435 | IN | denotes | of |
| T612 | 436-440 | DT | denotes | this |
| T613 | 441-446 | NN | denotes | study |
| T614 | 447-450 | VB | denotes | was |
| T615 | 451-453 | TO | denotes | to |
| R432 | T543 | T544 | arg1Of | NF-κB,and |
| R433 | T544 | T542 | arg2Of | and,by |
| R434 | T545 | T544 | arg2Of | AP-1,and |
| R435 | T548 | T546 | arg2Of | T-cells,in |
| R436 | T548 | T547 | arg1Of | T-cells,Jurkat |
| R437 | T551 | T550 | arg1Of | protein,Activator |
| R438 | T551 | T552 | arg1Of | protein,( |
| R439 | T551 | T555 | arg1Of | protein,-1 |
| R440 | T551 | T556 | arg1Of | protein,and |
| R441 | T553 | T552 | arg2Of | AP,( |
| R442 | T554 | T552 | arg3Of | ),( |
| R443 | T556 | T564 | arg1Of | and,control |
| R444 | T560 | T559 | arg2Of | NF,( |
| R445 | T561 | T559 | arg3Of | ),( |
| R446 | T562 | T556 | arg2Of | -κB,and |
| R447 | T562 | T557 | arg1Of | -κB,nuclear |
| R448 | T562 | T558 | arg1Of | -κB,factor |
| R449 | T562 | T559 | arg1Of | -κB,( |
| R450 | T564 | T563 | arg1Of | control,largely |
| R451 | T564 | T567 | arg1Of | control,"," |
| R452 | T564 | T568 | arg1Of | control,following |
| R453 | T566 | T564 | arg2Of | activation,control |
| R454 | T566 | T565 | arg1Of | activation,T-cell |
| R455 | T569 | T568 | arg2Of | binding,following |
| R456 | T569 | T570 | arg1Of | binding,of |
| R457 | T569 | T573 | arg1Of | binding,to |
| R458 | T572 | T570 | arg2Of | antigens,of |
| R459 | T572 | T571 | arg1Of | antigens,foreign |
| R460 | T576 | T573 | arg2Of | receptor,to |
| R461 | T576 | T574 | arg1Of | receptor,the |
| R462 | T576 | T575 | arg1Of | receptor,T-cell |
| R463 | T576 | T577 | arg1Of | receptor,leading |
| R464 | T577 | T578 | arg1Of | leading,to |
| R465 | T580 | T578 | arg2Of | secretion,to |
| R466 | T580 | T579 | arg1Of | secretion,cytokine |
| R467 | T582 | T581 | arg1Of | levels,Elevated |
| R468 | T582 | T583 | arg1Of | levels,of |
| R469 | T582 | T595 | arg1Of | levels,are |
| R470 | T582 | T596 | arg2Of | levels,associated |
| R471 | T585 | T586 | arg1Of | cytokines,and |
| R472 | T586 | T583 | arg2Of | and,of |
| R473 | T586 | T584 | arg1Of | and,pro-inflammatory |
| R474 | T586 | T589 | arg1Of | and,as |
| R475 | T587 | T586 | arg2Of | chemokines,and |
| R476 | T589 | T588 | arg1Of | as,such |
| R477 | T590 | T591 | arg1Of | TNF,"," |
| R478 | T591 | T593 | arg1Of | ",",and |
| R479 | T592 | T591 | arg2Of | IL-6,"," |
| R480 | T593 | T589 | arg2Of | and,as |
| R481 | T594 | T593 | arg2Of | CXCL8,and |
| R482 | T596 | T595 | arg2Of | associated,are |
| R483 | T596 | T597 | arg1Of | associated,with |
| R484 | T600 | T597 | arg2Of | diseases,with |
| R485 | T600 | T598 | arg1Of | diseases,several |
| R486 | T600 | T599 | arg1Of | diseases,human |
| R487 | T600 | T601 | arg1Of | diseases,including |
| R488 | T603 | T602 | arg1Of | fibrosis,cystic |
| R489 | T603 | T604 | arg1Of | fibrosis,"," |
| R490 | T604 | T607 | arg1Of | ",",and |
| R491 | T606 | T604 | arg2Of | fibrosis,"," |
| R492 | T606 | T605 | arg1Of | fibrosis,pulmonary |
| R493 | T607 | T601 | arg2Of | and,including |
| R494 | T608 | T607 | arg2Of | AIDS,and |
| R495 | T610 | T609 | arg1Of | aim,The |
| R496 | T610 | T611 | arg1Of | aim,of |
| R497 | T610 | T614 | arg1Of | aim,was |
| R498 | T613 | T611 | arg2Of | study,of |
| R499 | T613 | T612 | arg1Of | study,this |
bionlp-st-ge-2016-spacy-parsed
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T166 | 143-144 | , | denotes | , |
| T167 | 145-154 | VBG | denotes | following |
| T168 | 155-162 | JJ | denotes | binding |
| T169 | 163-165 | IN | denotes | of |
| T170 | 166-173 | JJ | denotes | foreign |
| T171 | 174-182 | NNS | denotes | antigens |
| T172 | 183-185 | TO | denotes | to |
| T173 | 186-189 | DT | denotes | the |
| T174 | 190-196 | NN | denotes | T-cell |
| T175 | 197-205 | NN | denotes | receptor |
| T176 | 206-213 | VBG | denotes | leading |
| T177 | 214-216 | TO | denotes | to |
| T178 | 217-225 | VB | denotes | cytokine |
| T179 | 226-235 | NN | denotes | secretion |
| T180 | 235-236 | . | denotes | . |
| T181 | 237-245 | JJ | denotes | Elevated |
| T182 | 246-252 | NNS | denotes | levels |
| T183 | 253-255 | IN | denotes | of |
| T184 | 256-272 | JJ | denotes | pro-inflammatory |
| T185 | 273-282 | NNS | denotes | cytokines |
| T186 | 283-286 | CC | denotes | and |
| T187 | 287-297 | NNS | denotes | chemokines |
| T188 | 298-302 | JJ | denotes | such |
| T189 | 303-305 | IN | denotes | as |
| T190 | 306-309 | NNP | denotes | TNF |
| T191 | 309-310 | , | denotes | , |
| T192 | 311-315 | NNP | denotes | IL-6 |
| T193 | 316-319 | CC | denotes | and |
| T194 | 320-325 | NNP | denotes | CXCL8 |
| T195 | 326-329 | VBP | denotes | are |
| T196 | 330-340 | VBN | denotes | associated |
| T197 | 341-345 | IN | denotes | with |
| T198 | 346-353 | JJ | denotes | several |
| T199 | 354-359 | JJ | denotes | human |
| T200 | 360-368 | NNS | denotes | diseases |
| T201 | 369-378 | VBG | denotes | including |
| T202 | 379-385 | JJ | denotes | cystic |
| T203 | 386-394 | NN | denotes | fibrosis |
| T204 | 394-395 | , | denotes | , |
| T205 | 396-405 | JJ | denotes | pulmonary |
| T206 | 406-414 | NN | denotes | fibrosis |
| T207 | 415-418 | CC | denotes | and |
| T208 | 419-423 | NNP | denotes | AIDS |
| T209 | 423-424 | . | denotes | . |
| T210 | 425-428 | DT | denotes | The |
| T211 | 429-432 | NN | denotes | aim |
| T212 | 433-435 | IN | denotes | of |
| T213 | 436-440 | DT | denotes | this |
| T214 | 441-446 | NN | denotes | study |
| T215 | 447-450 | VBD | denotes | was |
| T216 | 451-453 | TO | denotes | to |
| T140 | 0-2 | IN | denotes | by |
| T141 | 3-8 | NNP | denotes | NF-κB |
| T142 | 9-12 | CC | denotes | and |
| T143 | 13-17 | NNP | denotes | AP-1 |
| T144 | 18-20 | IN | denotes | in |
| T145 | 21-27 | NNP | denotes | Jurkat |
| T146 | 28-35 | NNP | denotes | T-cells |
| T147 | 47-57 | NNP | denotes | Background |
| T148 | 58-67 | NNP | denotes | Activator |
| T149 | 68-75 | NN | denotes | protein |
| T150 | 76-77 | -LRB- | denotes | ( |
| T151 | 77-79 | NNP | denotes | AP |
| T152 | 79-80 | -RRB- | denotes | ) |
| T153 | 80-82 | CD | denotes | -1 |
| T154 | 83-86 | CC | denotes | and |
| T155 | 87-94 | JJ | denotes | nuclear |
| T156 | 95-101 | NN | denotes | factor |
| T157 | 102-103 | -LRB- | denotes | ( |
| T158 | 103-105 | NNP | denotes | NF |
| T159 | 105-106 | -RRB- | denotes | ) |
| T160 | 106-107 | : | denotes | - |
| T161 | 107-109 | NN | denotes | κB |
| T162 | 110-117 | RB | denotes | largely |
| T163 | 118-125 | JJ | denotes | control |
| T164 | 126-132 | NNP | denotes | T-cell |
| T165 | 133-143 | NN | denotes | activation |
| R58 | T168 | T167 | pobj | binding,following |
| R59 | T169 | T168 | prep | of,binding |
| R60 | T170 | T171 | amod | foreign,antigens |
| R61 | T171 | T169 | pobj | antigens,of |
| R62 | T172 | T168 | prep | to,binding |
| R63 | T173 | T175 | det | the,receptor |
| R56 | T166 | T165 | punct | ",",activation |
| R64 | T174 | T175 | compound | T-cell,receptor |
| R65 | T175 | T172 | pobj | receptor,to |
| R66 | T176 | T175 | acl | leading,receptor |
| R67 | T177 | T176 | prep | to,leading |
| R68 | T178 | T179 | amod | cytokine,secretion |
| R69 | T179 | T177 | pobj | secretion,to |
| R71 | T181 | T182 | amod | Elevated,levels |
| R72 | T182 | T196 | nsubjpass | levels,associated |
| R73 | T183 | T182 | prep | of,levels |
| R74 | T184 | T185 | amod | pro-inflammatory,cytokines |
| R75 | T185 | T183 | pobj | cytokines,of |
| R76 | T186 | T185 | cc | and,cytokines |
| R77 | T187 | T185 | conj | chemokines,cytokines |
| R78 | T188 | T189 | amod | such,as |
| R79 | T189 | T187 | prep | as,chemokines |
| R80 | T190 | T189 | pobj | TNF,as |
| R81 | T191 | T190 | punct | ",",TNF |
| R82 | T192 | T190 | conj | IL-6,TNF |
| R83 | T193 | T192 | cc | and,IL-6 |
| R84 | T194 | T192 | conj | CXCL8,IL-6 |
| R85 | T195 | T196 | auxpass | are,associated |
| R86 | T196 | T196 | ROOT | associated,associated |
| R87 | T197 | T196 | prep | with,associated |
| R88 | T198 | T200 | amod | several,diseases |
| R89 | T199 | T200 | amod | human,diseases |
| R90 | T200 | T197 | pobj | diseases,with |
| R91 | T201 | T200 | prep | including,diseases |
| R92 | T202 | T203 | amod | cystic,fibrosis |
| R93 | T203 | T201 | pobj | fibrosis,including |
| R94 | T204 | T203 | punct | ",",fibrosis |
| R95 | T205 | T206 | amod | pulmonary,fibrosis |
| R96 | T206 | T203 | conj | fibrosis,fibrosis |
| R97 | T207 | T206 | cc | and,fibrosis |
| R98 | T208 | T206 | conj | AIDS,fibrosis |
| R99 | T209 | T196 | punct | .,associated |
| R100 | T210 | T211 | det | The,aim |
| R101 | T211 | T215 | nsubj | aim,was |
| R102 | T212 | T211 | prep | of,aim |
| R103 | T213 | T214 | det | this,study |
| R104 | T214 | T212 | pobj | study,of |
| R105 | T215 | T215 | ROOT | was,was |
| R962 | T142 | T141 | cc | and,NF-κB |
| R963 | T143 | T141 | conj | AP-1,NF-κB |
| R965 | T145 | T149 | compound | Jurkat,protein |
| R966 | T146 | T149 | compound | T-cells,protein |
| R967 | T147 | T148 | compound | Background,Activator |
| R968 | T148 | T149 | compound | Activator,protein |
| R969 | T149 | T144 | pobj | protein,in |
| R970 | T150 | T151 | punct | (,AP |
| R971 | T151 | T149 | appos | AP,protein |
| R972 | T152 | T151 | punct | ),AP |
| R973 | T153 | T151 | nummod | -1,AP |
| R974 | T154 | T149 | cc | and,protein |
| R975 | T155 | T156 | amod | nuclear,factor |
| R976 | T156 | T149 | conj | factor,protein |
| R977 | T157 | T158 | punct | (,NF |
| R978 | T158 | T156 | appos | NF,factor |
| R979 | T159 | T158 | punct | ),NF |
| R980 | T160 | T161 | punct | -,κB |
| R981 | T161 | T165 | amod | κB,activation |
| R982 | T162 | T163 | advmod | largely,control |
| R983 | T163 | T165 | amod | control,activation |
| R984 | T164 | T165 | compound | T-cell,activation |
| R961 | T141 | T140 | pobj | NF-κB,by |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T978 | 126-143 | http://purl.obolibrary.org/obo/GO_0051132 | denotes | T-cell activation |
| T979 | 126-143 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T-cell activation |
| T980 | 126-143 | http://purl.obolibrary.org/obo/GO_0050798 | denotes | T-cell activation |
| T981 | 126-143 | http://purl.obolibrary.org/obo/GO_0050863 | denotes | T-cell activation |
| T982 | 126-143 | http://purl.obolibrary.org/obo/GO_1903905 | denotes | T-cell activation |
| T983 | 128-143 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
| T984 | 217-235 | http://purl.obolibrary.org/obo/GO_0050663 | denotes | cytokine secretion |
| T985 | 226-235 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1003 | 155-162 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
| T1004 | 190-205 | http://purl.obolibrary.org/obo/GO_0042608 | denotes | T-cell receptor |
| T1005 | 311-315 | http://purl.obolibrary.org/obo/GO_0005138 | denotes | IL-6 |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1018 | 30-35 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T1021 | 190-205 | http://purl.obolibrary.org/obo/GO_0042101 | denotes | T-cell receptor |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T120 | 47-57 | Sentence | denotes | Background |
| T121 | 58-236 | Sentence | denotes | Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion. |
| T122 | 237-424 | Sentence | denotes | Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with several human diseases including cystic fibrosis, pulmonary fibrosis and AIDS. |
| T2 | 38-46 | Sentence | denotes | Abstract |
| T3 | 47-57 | Sentence | denotes | Background |
| T4 | 58-236 | Sentence | denotes | Activator protein (AP)-1 and nuclear factor (NF)-κB largely control T-cell activation, following binding of foreign antigens to the T-cell receptor leading to cytokine secretion. |
| T5 | 237-424 | Sentence | denotes | Elevated levels of pro-inflammatory cytokines and chemokines such as TNF, IL-6 and CXCL8 are associated with several human diseases including cystic fibrosis, pulmonary fibrosis and AIDS. |
ICD10
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1002 | 379-405 | http://purl.bioontology.org/ontology/ICD10/E84.0 | denotes | cystic fibrosis, pulmonary |
| T1000 | 379-394 | http://purl.bioontology.org/ontology/ICD10/E84 | denotes | cystic fibrosis |
| T1001 | 379-394 | http://purl.bioontology.org/ontology/ICD10/E84.9 | denotes | cystic fibrosis |
events-check-again
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1212 | 311-315 | Protein | denotes | IL-6 |
| T1213 | 320-325 | Protein | denotes | CXCL8 |
bionlp-st-ge-2016-reference-tees
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1252 | 3-8 | Protein | denotes | NF-κB |
| T1253 | 13-17 | Protein | denotes | AP-1 |
| T1254 | 107-109 | Protein | denotes | κB |
| T1255 | 155-162 | Binding | denotes | binding |
| T1256 | 306-309 | Protein | denotes | TNF |
| T1257 | 311-315 | Protein | denotes | IL-6 |
| T1258 | 320-325 | Protein | denotes | CXCL8 |
| R898 | T1254 | T1255 | themeOf | κB,binding |
bionlp-st-ge-2016-reference
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 311-315 | Protein | denotes | IL-6 |
| T80 | 320-325 | Protein | denotes | CXCL8 |
bionlp-st-ge-2016-uniprot
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T928 | 429-432 | P26358 | denotes | aim |
| T924 | 13-17 | P05412 | denotes | AP-1 |
| T925 | 306-309 | P01375 | denotes | TNF |
| T926 | 311-315 | P05231 | denotes | IL-6 |
| T927 | 320-325 | P10145 | denotes | CXCL8 |
test2
| Id | Subject | Object | Predicate | Lexical cue | Negation |
|---|---|---|---|---|---|
| T41 | 311-315 | Protein | denotes | IL-6 | true |
| T42 | 320-325 | Protein | denotes | CXCL8 | |
| T43 | 330-340 | Binding | denotes | associated | true |
| R22 | T41 | T43 | themeOf | IL-6,associated | |
| R23 | T42 | T43 | themeOf | CXCL8,associated |