PMC:2889865 / 2473-5330 JSON TXT

Annnotations TAB JSON ListView MergeView

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T2024	11-20	NN	denotes	Cytokines
T2025	21-24	CC	denotes	and
T2026	25-35	NN	denotes	chemokines
T2027	36-39	VB	denotes	are
T2028	40-49	JJ	denotes	important
T2029	50-52	IN	denotes	in
T2030	53-59	JJ	denotes	immune
T2031	60-64	NN	denotes	cell
T2032	65-76	NN	denotes	recruitment
T2033	77-80	CC	denotes	and
T2034	81-83	IN	denotes	in
T2035	84-94	NN	denotes	regulation
T2036	95-97	IN	denotes	of
T2037	98-110	JJ	denotes	inflammatory
T2038	111-120	NN	denotes	responses
T2039	121-122	-LRB-	denotes	[
T2040	122-123	CD	denotes	1
T2041	123-124	-RRB-	denotes	]
T2042	126-133	NN	denotes	T-cells
T2043	134-141	VB	denotes	produce
T2044	142-143	DT	denotes	a
T2045	144-149	JJ	denotes	broad
T2046	150-155	NN	denotes	range
T2047	156-158	IN	denotes	of
T2048	159-171	JJ	denotes	inflammatory
T2049	172-181	NN	denotes	mediators
T2050	181-182	-COMMA-	denotes	,
T2051	183-192	VB	denotes	including
T2052	193-197	NN	denotes	IL-2
T2053	197-198	-COMMA-	denotes	,
T2054	199-203	NN	denotes	IL-6
T2055	203-204	-COMMA-	denotes	,
T2056	205-208	NN	denotes	TNF
T2057	209-212	CC	denotes	and
T2058	213-218	NN	denotes	CXCL8
T2059	218-219	-COMMA-	denotes	,
T2060	220-223	DT	denotes	all
T2061	224-226	IN	denotes	of
T2062	227-232	WDT	denotes	which
T2063	233-236	VB	denotes	are
T2064	237-246	JJ	denotes	important
T2065	247-249	IN	denotes	in
T2066	250-254	NN	denotes	cell
T2067	255-268	NN	denotes	proliferation
T2068	268-269	-COMMA-	denotes	,
T2069	270-285	NN	denotes	differentiation
T2070	285-286	-COMMA-	denotes	,
T2071	287-300	NN	denotes	communication
T2072	301-304	CC	denotes	and
T2073	305-315	NN	denotes	initiation
T2074	316-318	IN	denotes	of
T2075	319-331	JJ	denotes	inflammatory
T2076	332-341	NN	denotes	responses
T2077	342-343	-LRB-	denotes	[
T2078	343-344	CD	denotes	2
T2079	344-345	-RRB-	denotes	]
T2080	347-355	JJ	denotes	Elevated
T2081	356-362	NN	denotes	levels
T2082	363-365	IN	denotes	of
T2083	366-382	JJ	denotes	pro-inflammatory
T2084	383-392	NN	denotes	cytokines
T2085	393-396	CC	denotes	and
T2086	397-407	NN	denotes	chemokines
T2087	407-408	-COMMA-	denotes	,
T2088	409-413	JJ	denotes	such
T2089	414-416	IN	denotes	as
T2090	417-420	NN	denotes	TNF
T2091	420-421	-COMMA-	denotes	,
T2092	422-426	NN	denotes	IL-6
T2093	427-430	CC	denotes	and
T2094	431-436	NN	denotes	CXCL8
T2095	436-437	-COMMA-	denotes	,
T2096	438-441	VB	denotes	are
T2097	442-452	VB	denotes	associated
T2098	453-457	IN	denotes	with
T2099	458-465	JJ	denotes	several
T2100	466-471	JJ	denotes	human
T2101	472-480	NN	denotes	diseases
T2102	481-490	VB	denotes	including
T2103	491-497	JJ	denotes	cystic
T2104	498-506	NN	denotes	fibrosis
T2105	507-508	-LRB-	denotes	[
T2106	508-511	CD	denotes	3-5
T2107	511-512	-RRB-	denotes	]
T2108	512-513	-COMMA-	denotes	,
T2109	514-523	JJ	denotes	pulmonary
T2110	524-532	NN	denotes	fibrosis
T2111	533-534	-LRB-	denotes	[
T2112	534-537	CD	denotes	6,7
T2113	537-538	-RRB-	denotes	]
T2114	539-542	CC	denotes	and
T2115	543-547	NNP	denotes	AIDS
T2116	548-549	-LRB-	denotes	[
T2117	549-552	CD	denotes	8,9
T2118	552-553	-RRB-	denotes	]
T2119	555-564	NN	denotes	Induction
T2120	565-567	IN	denotes	of
T2121	568-573	NN	denotes	CXCL8
T2122	574-577	VB	denotes	has
T2123	578-582	VB	denotes	been
T2124	583-592	VB	denotes	suggested
T2125	593-595	TO	denotes	to
T2126	596-598	VB	denotes	be
T2127	599-607	VB	denotes	mediated
T2128	608-615	IN	denotes	through
T2129	616-621	NN	denotes	NF-κB
T2130	622-624	IN	denotes	in
T2131	625-636	NN	denotes	cooperation
T2132	637-641	IN	denotes	with
T2133	642-646	NN	denotes	AP-1
T2134	647-648	-LRB-	denotes	[
T2135	648-653	CD	denotes	10,11
T2136	653-654	-RRB-	denotes	]
T2137	654-655	-COMMA-	denotes	,
T2138	656-663	RB	denotes	however
T2139	664-667	DT	denotes	the
T2140	668-675	JJ	denotes	precise
T2141	676-685	NN	denotes	mechanism
T2142	686-688	VB	denotes	is
T2143	689-692	RB	denotes	not
T2144	693-698	RB	denotes	fully
T2145	699-709	VB	denotes	elucidated
T2146	709-710	-COMMA-	denotes	,
T2147	711-714	CC	denotes	and
T2148	715-724	NN	denotes	treatment
T2149	725-735	NN	denotes	strategies
T2150	736-741	VB	denotes	aimed
T2151	742-744	IN	denotes	at
T2152	745-755	VB	denotes	inhibiting
T2153	756-761	NN	denotes	CXCL8
T2154	762-766	VB	denotes	have
T2155	767-773	VB	denotes	failed
T2156	774-775	-LRB-	denotes	[
T2157	775-777	CD	denotes	12
T2158	777-778	-RRB-	denotes	]
T2159	780-790	JJ	denotes	Persistent
T2160	791-801	NN	denotes	production
T2161	802-804	IN	denotes	of
T2162	805-809	NN	denotes	IL-6
T2163	810-813	CC	denotes	and
T2164	814-819	NN	denotes	CXCL8
T2165	820-825	VB	denotes	leads
T2166	826-828	TO	denotes	to
T2167	829-836	JJ	denotes	chronic
T2168	837-849	NN	denotes	inflammation
T2169	850-853	CC	denotes	and
T2170	854-862	VB	denotes	enhanced
T2171	863-871	NN	denotes	survival
T2172	872-874	IN	denotes	of
T2173	875-886	NN	denotes	lymphocytes
T2174	887-897	VB	denotes	increasing
T2175	898-903	NN	denotes	serum
T2176	904-922	NN	denotes	cytokine/chemokine
T2177	923-929	NN	denotes	levels
T2178	931-935	DT	denotes	This
T2179	936-941	VB	denotes	forms
T2180	942-945	DT	denotes	the
T2181	946-951	NN	denotes	basis
T2182	952-954	IN	denotes	of
T2183	955-962	JJ	denotes	several
T2184	963-973	JJ	denotes	autoimmune
T2185	974-983	NN	denotes	disorders
T2186	984-993	VB	denotes	including
T2187	994-1007	NN	denotes	plasmacytosis
T2188	1008-1011	CC	denotes	and
T2189	1012-1023	NN	denotes	hyperplasia
T2190	1024-1025	-LRB-	denotes	[
T2191	1025-1027	CD	denotes	13
T2192	1027-1028	-RRB-	denotes	]
T2193	1030-1032	TO	denotes	To
T2194	1033-1040	VB	denotes	develop
T2195	1041-1047	JJ	denotes	viable
T2196	1048-1053	NN	denotes	CXCL8
T2197	1054-1059	VB	denotes	based
T2198	1060-1069	NN	denotes	treatment
T2199	1070-1080	NN	denotes	strategies
T2200	1080-1081	-COMMA-	denotes	,
T2201	1082-1084	PRP	denotes	it
T2202	1085-1087	VB	denotes	is
T2203	1088-1097	JJ	denotes	necessary
T2204	1098-1100	TO	denotes	to
T2205	1101-1109	VB	denotes	identify
T2206	1110-1113	DT	denotes	the
T2207	1114-1124	NN	denotes	signalling
T2208	1125-1133	NN	denotes	pathways
T2209	1134-1144	VB	denotes	regulating
T2210	1145-1150	NN	denotes	CXCL8
T2211	1151-1154	CC	denotes	and
T2212	1155-1164	VB	denotes	determine
T2213	1165-1168	WRB	denotes	how
T2214	1169-1173	DT	denotes	this
T2215	1174-1176	VB	denotes	is
T2216	1177-1184	VB	denotes	coupled
T2217	1185-1187	TO	denotes	to
T2218	1188-1193	NN	denotes	NF-κB
T2219	1193-1194	-COMMA-	denotes	,
T2220	1195-1199	NN	denotes	AP-1
T2221	1200-1203	CC	denotes	and
T2222	1204-1208	NN	denotes	IL-6
T2223	1210-1213	DT	denotes	The
T2224	1214-1224	NN	denotes	signalling
T2225	1225-1233	NN	denotes	pathways
T2226	1234-1241	VB	denotes	leading
T2227	1242-1244	TO	denotes	to
T2228	1245-1250	NN	denotes	NF-κB
T2229	1251-1254	CC	denotes	and
T2230	1255-1259	NN	denotes	AP-1
T2231	1260-1270	NN	denotes	activation
T2232	1271-1274	VB	denotes	are
T2233	1275-1286	VB	denotes	overlapping
T2234	1286-1287	-COMMA-	denotes	,
T2235	1288-1293	WRB	denotes	where
T2236	1294-1298	DT	denotes	both
T2237	1299-1302	VB	denotes	are
T2238	1303-1311	VB	denotes	involved
T2239	1312-1314	IN	denotes	in
T2240	1315-1318	DT	denotes	the
T2241	1319-1328	NN	denotes	induction
T2242	1329-1332	CC	denotes	and
T2243	1333-1343	NN	denotes	regulation
T2244	1344-1346	IN	denotes	of
T2245	1347-1367	NN	denotes	cytokines/chemokines
T2246	1369-1374	NN	denotes	NF-κB
T2247	1375-1377	VB	denotes	is
T2248	1378-1387	VB	denotes	activated
T2249	1388-1390	IN	denotes	in
T2250	1391-1399	NN	denotes	response
T2251	1400-1402	TO	denotes	to
T2252	1403-1409	NN	denotes	stress
T2253	1409-1410	-COMMA-	denotes	,
T2254	1411-1415	JJ	denotes	such
T2255	1416-1418	IN	denotes	as
T2256	1419-1428	JJ	denotes	oxidative
T2257	1429-1435	NN	denotes	stress
T2258	1435-1436	-COMMA-	denotes	,
T2259	1437-1446	JJ	denotes	bacterial
T2260	1447-1453	NN	denotes	toxins
T2261	1453-1454	-COMMA-	denotes	,
T2262	1455-1462	NN	denotes	viruses
T2263	1463-1466	CC	denotes	and
T2264	1467-1469	NN	denotes	UV
T2265	1470-1475	NN	denotes	light
T2266	1476-1477	-LRB-	denotes	[
T2267	1477-1479	CD	denotes	14
T2268	1479-1480	-RRB-	denotes	]
T2269	1480-1481	-COMMA-	denotes	,
T2270	1482-1485	CC	denotes	and
T2271	1486-1488	VB	denotes	is
T2272	1489-1498	JJ	denotes	essential
T2273	1499-1502	IN	denotes	for
T2274	1503-1518	NN	denotes	differentiation
T2275	1518-1519	-COMMA-	denotes	,
T2276	1520-1533	NN	denotes	proliferation
T2277	1534-1537	CC	denotes	and
T2278	1538-1546	NN	denotes	survival
T2279	1547-1549	IN	denotes	of
T2280	1550-1554	JJ	denotes	many
T2281	1555-1559	NN	denotes	cell
T2282	1560-1565	NN	denotes	types
T2283	1566-1575	VB	denotes	including
T2284	1576-1589	NN	denotes	T-lymphocytes
T2285	1590-1591	-LRB-	denotes	[
T2286	1591-1593	CD	denotes	15
T2287	1593-1594	-RRB-	denotes	]
T2288	1596-1600	NN	denotes	AP-1
T2289	1601-1611	NN	denotes	activation
T2290	1612-1620	VB	denotes	requires
T2291	1621-1624	NN	denotes	Fos
T2292	1625-1626	-LRB-	denotes	(
T2293	1626-1631	NN	denotes	c-Fos
T2294	1631-1632	-COMMA-	denotes	,
T2295	1633-1637	NN	denotes	FosB
T2296	1637-1638	-COMMA-	denotes	,
T2297	1639-1644	NN	denotes	Fra-1
T2298	1644-1645	-COMMA-	denotes	,
T2299	1646-1651	NN	denotes	Fra-2
T2300	1651-1652	-RRB-	denotes	)
T2301	1653-1656	CC	denotes	and
T2302	1657-1660	NN	denotes	Jun
T2303	1661-1662	-LRB-	denotes	(
T2304	1662-1667	NN	denotes	c-Jun
T2305	1667-1668	-COMMA-	denotes	,
T2306	1669-1674	NN	denotes	v-Jun
T2307	1674-1675	-COMMA-	denotes	,
T2308	1676-1680	NN	denotes	JunB
T2309	1680-1681	-COMMA-	denotes	,
T2310	1682-1686	NN	denotes	JunD
T2311	1686-1687	-RRB-	denotes	)
T2312	1688-1695	IN	denotes	through
T2313	1696-1699	DT	denotes	the
T2314	1700-1709	NN	denotes	formation
T2315	1710-1712	IN	denotes	of
T2316	1713-1718	JJ	denotes	homo-
T2317	1719-1722	CC	denotes	and
T2318	1723-1736	NN	denotes	hetero-dimers
T2319	1737-1738	-LRB-	denotes	[
T2320	1738-1743	CD	denotes	16,17
T2321	1743-1744	-RRB-	denotes	]
T2322	1744-1745	-COMMA-	denotes	,
T2323	1746-1749	CC	denotes	and
T2324	1750-1759	VB	denotes	regulates
T2325	1760-1773	NN	denotes	transcription
T2326	1774-1776	IN	denotes	of
T2327	1777-1778	DT	denotes	a
T2328	1779-1784	JJ	denotes	broad
T2329	1785-1790	NN	denotes	range
T2330	1791-1793	IN	denotes	of
T2331	1794-1799	NN	denotes	genes
T2332	1800-1808	VB	denotes	involved
T2333	1809-1811	IN	denotes	in
T2334	1812-1818	JJ	denotes	immune
T2335	1819-1828	NN	denotes	responses
T2336	1829-1830	-LRB-	denotes	[
T2337	1830-1835	CD	denotes	18-21
T2338	1835-1836	-RRB-	denotes	]
T2339	1838-1842	CC	denotes	Both
T2340	1843-1847	NN	denotes	AP-1
T2341	1848-1851	CC	denotes	and
T2342	1852-1857	NN	denotes	NF-κB
T2343	1858-1865	NN	denotes	binding
T2344	1866-1871	NN	denotes	sites
T2345	1872-1876	VB	denotes	have
T2346	1877-1881	VB	denotes	been
T2347	1882-1892	VB	denotes	identified
T2348	1893-1895	IN	denotes	in
T2349	1896-1899	DT	denotes	the
T2350	1900-1908	NN	denotes	promoter
T2351	1909-1915	NN	denotes	region
T2352	1916-1918	IN	denotes	of
T2353	1919-1923	NN	denotes	IL-6
T2354	1924-1927	CC	denotes	and
T2355	1928-1933	NN	denotes	CXCL8
T2356	1934-1935	-LRB-	denotes	[
T2357	1935-1940	CD	denotes	12,22
T2358	1940-1941	-RRB-	denotes	]
T2359	1941-1942	-COMMA-	denotes	,
T2360	1943-1950	RB	denotes	however
T2361	1950-1951	-COMMA-	denotes	,
T2362	1952-1955	DT	denotes	the
T2363	1956-1965	NN	denotes	mechanism
T2364	1966-1968	IN	denotes	by
T2365	1969-1974	WDT	denotes	which
T2366	1975-1980	DT	denotes	these
T2367	1981-1993	NN	denotes	interleukins
T2368	1994-1997	VB	denotes	are
T2369	1998-2007	VB	denotes	regulated
T2370	2008-2010	IN	denotes	in
T2371	2011-2018	NN	denotes	T-cells
T2372	2019-2021	VB	denotes	is
T2373	2022-2027	RB	denotes	still
T2374	2028-2031	RB	denotes	not
T2375	2032-2037	JJ	denotes	clear
T2376	2039-2044	NN	denotes	CXCL8
T2377	2045-2047	VB	denotes	is
T2378	2048-2049	DT	denotes	a
T2379	2050-2055	NN	denotes	C-X-C
T2380	2056-2065	NN	denotes	chemokine
T2381	2066-2070	IN	denotes	with
T2382	2071-2081	NN	denotes	properties
T2383	2082-2090	VB	denotes	enabling
T2384	2091-2093	PRP	denotes	it
T2385	2094-2096	TO	denotes	to
T2386	2097-2104	VB	denotes	recruit
T2387	2105-2112	NN	denotes	T-cells
T2388	2113-2116	CC	denotes	and
T2389	2117-2126	NN	denotes	basophils
T2390	2127-2130	CC	denotes	and
T2391	2131-2133	TO	denotes	to
T2392	2134-2142	VB	denotes	activate
T2393	2143-2154	NN	denotes	neutrophils
T2394	2155-2158	CC	denotes	and
T2395	2159-2168	NN	denotes	monocytes
T2396	2169-2170	-LRB-	denotes	[
T2397	2170-2172	CD	denotes	23
T2398	2172-2173	-RRB-	denotes	]
T2399	2175-2179	NN	denotes	IL-6
T2400	2180-2182	VB	denotes	is
T2401	2183-2184	DT	denotes	a
T2402	2185-2193	NN	denotes	cytokine
T2403	2194-2198	WDT	denotes	that
T2404	2199-2208	VB	denotes	possesses
T2405	2209-2213	CC	denotes	both
T2406	2214-2218	JJ	denotes	pro-
T2407	2219-2222	CC	denotes	and
T2408	2223-2240	JJ	denotes	anti-inflammatory
T2409	2241-2256	NN	denotes	characteristics
T2410	2257-2260	CC	denotes	and
T2411	2261-2265	DT	denotes	that
T2412	2266-2271	VB	denotes	plays
T2413	2272-2273	DT	denotes	a
T2414	2274-2277	JJ	denotes	key
T2415	2278-2282	NN	denotes	role
T2416	2283-2285	IN	denotes	in
T2417	2286-2300	NN	denotes	haematopoiesis
T2418	2301-2304	CC	denotes	and
T2419	2305-2316	NN	denotes	acute-phase
T2420	2317-2326	NN	denotes	responses
T2421	2327-2328	-LRB-	denotes	[
T2422	2328-2333	CD	denotes	24,25
T2423	2333-2334	-RRB-	denotes	]
T2424	2336-2339	DT	denotes	The
T2425	2340-2347	JJ	denotes	present
T2426	2348-2353	NN	denotes	study
T2427	2354-2362	VB	denotes	suggests
T2428	2363-2367	IN	denotes	that
T2429	2368-2371	DT	denotes	the
T2430	2372-2382	NN	denotes	regulation
T2431	2383-2385	IN	denotes	of
T2432	2386-2391	NN	denotes	CXCL8
T2433	2392-2395	CC	denotes	and
T2434	2396-2400	NN	denotes	IL-6
T2435	2401-2403	VB	denotes	is
T2436	2404-2413	JJ	denotes	uncoupled
T2437	2415-2420	VB	denotes	Using
T2438	2421-2427	NN	denotes	Jurkat
T2439	2428-2435	NN	denotes	T-cells
T2440	2436-2443	VB	denotes	exposed
T2441	2444-2446	TO	denotes	to
T2442	2447-2450	NN	denotes	PMA
T2443	2451-2454	CC	denotes	and
T2444	2455-2459	NN	denotes	heat
T2445	2460-2466	VB	denotes	killed
T2446	2467-2468	-LRB-	denotes	(
T2447	2468-2470	NN	denotes	HK
T2448	2470-2471	-RRB-	denotes	)
T2449	2472-2483	FW	denotes	Escherichia
T2450	2484-2488	FW	denotes	coli
T2451	2489-2495	NN	denotes	MG1655
T2452	2496-2498	IN	denotes	in
T2453	2499-2510	NN	denotes	combination
T2454	2511-2515	IN	denotes	with
T2455	2516-2526	NN	denotes	inhibitors
T2456	2527-2529	IN	denotes	of
T2457	2530-2535	NN	denotes	NF-κB
T2458	2535-2536	-COMMA-	denotes	,
T2459	2537-2540	NN	denotes	JNK
T2460	2541-2544	CC	denotes	and
T2461	2545-2548	NN	denotes	PKC
T2462	2548-2549	-COMMA-	denotes	,
T2463	2550-2552	PRP	denotes	we
T2464	2553-2565	VB	denotes	demonstrated
T2465	2566-2570	IN	denotes	that
T2466	2571-2576	NN	denotes	NF-κB
T2467	2577-2586	VB	denotes	regulates
T2468	2587-2591	NN	denotes	IL-6
T2469	2592-2602	NN	denotes	expression
T2470	2603-2608	IN	denotes	while
T2471	2609-2612	DT	denotes	the
T2472	2613-2623	NN	denotes	regulation
T2473	2624-2626	IN	denotes	of
T2474	2627-2632	NN	denotes	CXCL8
T2475	2633-2637	RB	denotes	more
T2476	2638-2645	RB	denotes	closely
T2477	2646-2656	VB	denotes	correlated
T2478	2657-2659	TO	denotes	to
T2479	2660-2664	NN	denotes	AP-1
T2480	2665-2673	NN	denotes	activity
T2481	2675-2680	DT	denotes	These
T2482	2681-2688	NN	denotes	results
T2483	2689-2697	VB	denotes	indicate
T2484	2698-2702	IN	denotes	that
T2485	2703-2713	NN	denotes	inhibition
T2486	2714-2716	IN	denotes	of
T2487	2717-2722	NN	denotes	NF-κB
T2488	2723-2725	VB	denotes	is
T2489	2726-2729	RB	denotes	not
T2490	2730-2732	DT	denotes	an
T2491	2733-2742	JJ	denotes	effective
T2492	2743-2751	NN	denotes	strategy
T2493	2752-2754	IN	denotes	in
T2494	2755-2765	VB	denotes	countering
T2495	2766-2769	DT	denotes	the
T2496	2770-2774	JJ	denotes	high
T2497	2775-2780	NN	denotes	CXCL8
T2498	2781-2791	NN	denotes	activities
T2499	2792-2794	IN	denotes	in
T2500	2795-2803	NN	denotes	diseases
T2501	2804-2808	JJ	denotes	such
T2502	2809-2811	IN	denotes	as
T2503	2812-2818	JJ	denotes	cystic
T2504	2819-2827	NN	denotes	fibrosis
T2505	2827-2828	-COMMA-	denotes	,
T2506	2829-2833	NN	denotes	AIDS
T2507	2834-2837	CC	denotes	and
T2508	2838-2847	JJ	denotes	pulmonary
T2509	2848-2856	NN	denotes	fibrosis
R1634	T2024	T2025	arg1Of	Cytokines,and
R1635	T2025	T2027	arg1Of	and,are
R1636	T2025	T2028	arg1Of	and,important
R1637	T2026	T2025	arg2Of	chemokines,and
R1638	T2027	T2039	arg1Of	are,[
R1639	T2028	T2027	arg2Of	important,are
R1640	T2028	T2029	arg1Of	important,in
R1641	T2028	T2034	arg1Of	important,in
R1642	T2029	T2033	arg1Of	in,and
R1643	T2032	T2029	arg2Of	recruitment,in
R1644	T2032	T2030	arg1Of	recruitment,immune
R1645	T2032	T2031	arg1Of	recruitment,cell
R1646	T2034	T2033	arg2Of	in,and
R1647	T2035	T2034	arg2Of	regulation,in
R1648	T2035	T2036	arg1Of	regulation,of
R1649	T2038	T2036	arg2Of	responses,of
R1650	T2038	T2037	arg1Of	responses,inflammatory
R1651	T2040	T2039	arg2Of	1,[
R1652	T2041	T2039	arg3Of	],[
R1653	T2042	T2043	arg1Of	T-cells,produce
R1654	T2046	T2043	arg2Of	range,produce
R1655	T2046	T2044	arg1Of	range,a
R1656	T2046	T2045	arg1Of	range,broad
R1657	T2046	T2047	arg1Of	range,of
R1658	T2049	T2047	arg2Of	mediators,of
R1659	T2049	T2048	arg1Of	mediators,inflammatory
R1660	T2049	T2050	arg1Of	mediators,","
R1661	T2049	T2051	arg1Of	mediators,including
R1662	T2052	T2053	arg1Of	IL-2,","
R1663	T2053	T2055	arg1Of	",",","
R1664	T2054	T2053	arg2Of	IL-6,","
R1665	T2055	T2057	arg1Of	",",and
R1666	T2056	T2055	arg2Of	TNF,","
R1667	T2057	T2051	arg2Of	and,including
R1668	T2057	T2059	arg1Of	and,","
R1669	T2057	T2061	arg2Of	and,of
R1670	T2057	T2062	arg1Of	and,which
R1671	T2058	T2057	arg2Of	CXCL8,and
R1672	T2060	T2061	arg1Of	all,of
R1673	T2060	T2063	arg1Of	all,are
R1674	T2060	T2064	arg1Of	all,important
R1675	T2063	T2077	arg1Of	are,[
R1676	T2064	T2063	arg2Of	important,are
R1677	T2064	T2065	arg1Of	important,in
R1678	T2067	T2066	arg1Of	proliferation,cell
R1679	T2067	T2068	arg1Of	proliferation,","
R1680	T2068	T2070	arg1Of	",",","
R1681	T2069	T2068	arg2Of	differentiation,","
R1682	T2070	T2072	arg1Of	",",and
R1683	T2071	T2070	arg2Of	communication,","
R1684	T2072	T2065	arg2Of	and,in
R1685	T2073	T2072	arg2Of	initiation,and
R1686	T2073	T2074	arg1Of	initiation,of
R1687	T2076	T2074	arg2Of	responses,of
R1688	T2076	T2075	arg1Of	responses,inflammatory
R1689	T2078	T2077	arg2Of	2,[
R1690	T2079	T2077	arg3Of	],[
R1691	T2081	T2080	arg1Of	levels,Elevated
R1692	T2081	T2082	arg1Of	levels,of
R1693	T2081	T2087	arg1Of	levels,","
R1694	T2081	T2089	arg1Of	levels,as
R1695	T2081	T2096	arg1Of	levels,are
R1696	T2081	T2097	arg2Of	levels,associated
R1697	T2084	T2083	arg1Of	cytokines,pro-inflammatory
R1698	T2084	T2085	arg1Of	cytokines,and
R1699	T2085	T2082	arg2Of	and,of
R1700	T2086	T2085	arg2Of	chemokines,and
R1701	T2089	T2088	arg1Of	as,such
R1702	T2090	T2091	arg1Of	TNF,","
R1703	T2091	T2093	arg1Of	",",and
R1704	T2092	T2091	arg2Of	IL-6,","
R1705	T2093	T2089	arg2Of	and,as
R1706	T2094	T2093	arg2Of	CXCL8,and
R1707	T2097	T2095	arg1Of	associated,","
R1708	T2097	T2096	arg2Of	associated,are
R1709	T2097	T2098	arg1Of	associated,with
R1710	T2101	T2098	arg2Of	diseases,with
R1711	T2101	T2099	arg1Of	diseases,several
R1712	T2101	T2100	arg1Of	diseases,human
R1713	T2101	T2102	arg1Of	diseases,including
R1714	T2104	T2103	arg1Of	fibrosis,cystic
R1715	T2104	T2105	arg1Of	fibrosis,[
R1716	T2104	T2108	arg1Of	fibrosis,","
R1717	T2106	T2105	arg2Of	3-5,[
R1718	T2107	T2105	arg3Of	],[
R1719	T2108	T2114	arg1Of	",",and
R1720	T2110	T2108	arg2Of	fibrosis,","
R1721	T2110	T2109	arg1Of	fibrosis,pulmonary
R1722	T2110	T2111	arg1Of	fibrosis,[
R1723	T2112	T2111	arg2Of	"6,7",[
R1724	T2113	T2111	arg3Of	],[
R1725	T2114	T2102	arg2Of	and,including
R1726	T2115	T2114	arg2Of	AIDS,and
R1727	T2115	T2116	arg1Of	AIDS,[
R1728	T2117	T2116	arg2Of	"8,9",[
R1729	T2118	T2116	arg3Of	],[
R1730	T2119	T2120	arg1Of	Induction,of
R1731	T2119	T2122	arg1Of	Induction,has
R1732	T2119	T2123	arg1Of	Induction,been
R1733	T2119	T2124	arg2Of	Induction,suggested
R1734	T2119	T2126	arg1Of	Induction,be
R1735	T2119	T2127	arg2Of	Induction,mediated
R1736	T2121	T2120	arg2Of	CXCL8,of
R1737	T2124	T2122	arg2Of	suggested,has
R1738	T2124	T2123	arg2Of	suggested,been
R1739	T2124	T2137	arg1Of	suggested,","
R1740	T2127	T2124	arg3Of	mediated,suggested
R1741	T2127	T2125	arg1Of	mediated,to
R1742	T2127	T2126	arg2Of	mediated,be
R1743	T2127	T2128	arg1Of	mediated,through
R1744	T2127	T2130	arg1Of	mediated,in
R1745	T2129	T2128	arg2Of	NF-κB,through
R1746	T2131	T2130	arg2Of	cooperation,in
R1747	T2131	T2132	arg1Of	cooperation,with
R1748	T2133	T2132	arg2Of	AP-1,with
R1749	T2133	T2134	arg1Of	AP-1,[
R1750	T2135	T2134	arg2Of	"10,11",[
R1751	T2136	T2134	arg3Of	],[
R1752	T2137	T2147	arg1Of	",",and
R1753	T2141	T2139	arg1Of	mechanism,the
R1754	T2141	T2140	arg1Of	mechanism,precise
R1755	T2141	T2142	arg1Of	mechanism,is
R1756	T2141	T2145	arg2Of	mechanism,elucidated
R1757	T2145	T2137	arg2Of	elucidated,","
R1758	T2145	T2138	arg1Of	elucidated,however
R1759	T2145	T2142	arg2Of	elucidated,is
R1760	T2145	T2143	arg1Of	elucidated,not
R1761	T2145	T2144	arg1Of	elucidated,fully
R1762	T2147	T2146	arg1Of	and,","
R1763	T2149	T2148	arg1Of	strategies,treatment
R1764	T2149	T2150	arg2Of	strategies,aimed
R1765	T2149	T2154	arg1Of	strategies,have
R1766	T2149	T2155	arg1Of	strategies,failed
R1767	T2150	T2151	arg1Of	aimed,at
R1768	T2152	T2151	arg2Of	inhibiting,at
R1769	T2153	T2152	arg2Of	CXCL8,inhibiting
R1770	T2155	T2147	arg2Of	failed,and
R1771	T2155	T2154	arg2Of	failed,have
R1772	T2155	T2156	arg1Of	failed,[
R1773	T2157	T2156	arg2Of	12,[
R1774	T2158	T2156	arg3Of	],[
R1775	T2160	T2159	arg1Of	production,Persistent
R1776	T2160	T2161	arg1Of	production,of
R1777	T2160	T2165	arg1Of	production,leads
R1778	T2162	T2163	arg1Of	IL-6,and
R1779	T2163	T2161	arg2Of	and,of
R1780	T2164	T2163	arg2Of	CXCL8,and
R1781	T2165	T2166	arg1Of	leads,to
R1782	T2168	T2167	arg1Of	inflammation,chronic
R1783	T2168	T2169	arg1Of	inflammation,and
R1784	T2169	T2166	arg2Of	and,to
R1785	T2171	T2169	arg2Of	survival,and
R1786	T2171	T2170	arg2Of	survival,enhanced
R1787	T2171	T2172	arg1Of	survival,of
R1788	T2173	T2172	arg2Of	lymphocytes,of
R1789	T2173	T2174	arg1Of	lymphocytes,increasing
R1790	T2177	T2174	arg2Of	levels,increasing
R1791	T2177	T2175	arg1Of	levels,serum
R1792	T2177	T2176	arg1Of	levels,cytokine/chemokine
R1793	T2178	T2179	arg1Of	This,forms
R1794	T2181	T2179	arg2Of	basis,forms
R1795	T2181	T2180	arg1Of	basis,the
R1796	T2181	T2182	arg1Of	basis,of
R1797	T2185	T2182	arg2Of	disorders,of
R1798	T2185	T2183	arg1Of	disorders,several
R1799	T2185	T2184	arg1Of	disorders,autoimmune
R1800	T2185	T2186	arg1Of	disorders,including
R1801	T2187	T2188	arg1Of	plasmacytosis,and
R1802	T2188	T2186	arg2Of	and,including
R1803	T2188	T2190	arg1Of	and,[
R1804	T2189	T2188	arg2Of	hyperplasia,and
R1805	T2191	T2190	arg2Of	13,[
R1806	T2192	T2190	arg3Of	],[
R1807	T2194	T2193	arg1Of	develop,To
R1808	T2199	T2194	arg2Of	strategies,develop
R1809	T2199	T2195	arg1Of	strategies,viable
R1810	T2199	T2196	arg1Of	strategies,CXCL8
R1811	T2199	T2197	arg2Of	strategies,based
R1812	T2199	T2198	arg1Of	strategies,treatment
R1813	T2202	T2193	modOf	is,To
R1814	T2202	T2200	arg1Of	is,","
R1815	T2203	T2202	arg2Of	necessary,is
R1816	T2205	T2211	arg1Of	identify,and
R1817	T2208	T2205	arg2Of	pathways,identify
R1818	T2208	T2206	arg1Of	pathways,the
R1819	T2208	T2207	arg1Of	pathways,signalling
R1820	T2208	T2209	arg1Of	pathways,regulating
R1821	T2210	T2209	arg2Of	CXCL8,regulating
R1822	T2211	T2194	arg1Of	and,develop
R1823	T2211	T2201	arg1Of	and,it
R1824	T2211	T2202	arg1Of	and,is
R1825	T2211	T2203	arg1Of	and,necessary
R1826	T2211	T2204	arg1Of	and,to
R1827	T2212	T2211	arg2Of	determine,and
R1828	T2213	T2212	arg2Of	how,determine
R1829	T2214	T2215	arg1Of	this,is
R1830	T2214	T2216	arg2Of	this,coupled
R1831	T2216	T2213	arg1Of	coupled,how
R1832	T2216	T2215	arg2Of	coupled,is
R1833	T2216	T2217	arg1Of	coupled,to
R1834	T2218	T2219	arg1Of	NF-κB,","
R1835	T2219	T2221	arg1Of	",",and
R1836	T2220	T2219	arg2Of	AP-1,","
R1837	T2221	T2217	arg2Of	and,to
R1838	T2222	T2221	arg2Of	IL-6,and
R1839	T2225	T2223	arg1Of	pathways,The
R1840	T2225	T2224	arg1Of	pathways,signalling
R1841	T2225	T2226	arg1Of	pathways,leading
R1842	T2225	T2232	arg1Of	pathways,are
R1843	T2225	T2233	arg1Of	pathways,overlapping
R1844	T2226	T2227	arg1Of	leading,to
R1845	T2228	T2229	arg1Of	NF-κB,and
R1846	T2230	T2229	arg2Of	AP-1,and
R1847	T2231	T2227	arg2Of	activation,to
R1848	T2231	T2228	arg1Of	activation,NF-κB
R1849	T2231	T2230	arg1Of	activation,AP-1
R1850	T2233	T2232	arg2Of	overlapping,are
R1851	T2233	T2234	arg1Of	overlapping,","
R1852	T2233	T2235	arg1Of	overlapping,where
R1853	T2236	T2237	arg1Of	both,are
R1854	T2236	T2238	arg2Of	both,involved
R1855	T2238	T2235	arg2Of	involved,where
R1856	T2238	T2237	arg2Of	involved,are
R1857	T2238	T2239	arg1Of	involved,in
R1858	T2241	T2242	arg1Of	induction,and
R1859	T2242	T2239	arg2Of	and,in
R1860	T2242	T2240	arg1Of	and,the
R1861	T2242	T2244	arg1Of	and,of
R1862	T2243	T2242	arg2Of	regulation,and
R1863	T2245	T2244	arg2Of	cytokines/chemokines,of
R1864	T2246	T2247	arg1Of	NF-κB,is
R1865	T2246	T2248	arg2Of	NF-κB,activated
R1866	T2246	T2271	arg1Of	NF-κB,is
R1867	T2246	T2272	arg1Of	NF-κB,essential
R1868	T2248	T2247	arg2Of	activated,is
R1869	T2248	T2249	arg1Of	activated,in
R1870	T2248	T2270	arg1Of	activated,and
R1871	T2249	T2251	arg1Of	in,to
R1872	T2250	T2249	arg2Of	response,in
R1873	T2252	T2249	arg3Of	stress,in
R1874	T2252	T2253	arg1Of	stress,","
R1875	T2252	T2255	arg1Of	stress,as
R1876	T2255	T2254	arg1Of	as,such
R1877	T2257	T2256	arg1Of	stress,oxidative
R1878	T2257	T2258	arg1Of	stress,","
R1879	T2258	T2261	arg1Of	",",","
R1880	T2260	T2258	arg2Of	toxins,","
R1881	T2260	T2259	arg1Of	toxins,bacterial
R1882	T2261	T2263	arg1Of	",",and
R1883	T2262	T2261	arg2Of	viruses,","
R1884	T2263	T2255	arg2Of	and,as
R1885	T2265	T2263	arg2Of	light,and
R1886	T2265	T2264	arg1Of	light,UV
R1887	T2265	T2266	arg1Of	light,[
R1888	T2267	T2266	arg2Of	14,[
R1889	T2268	T2266	arg3Of	],[
R1890	T2270	T2269	arg1Of	and,","
R1891	T2271	T2270	arg2Of	is,and
R1892	T2272	T2271	arg2Of	essential,is
R1893	T2272	T2273	arg1Of	essential,for
R1894	T2274	T2275	arg1Of	differentiation,","
R1895	T2275	T2277	arg1Of	",",and
R1896	T2276	T2275	arg2Of	proliferation,","
R1897	T2277	T2273	arg2Of	and,for
R1898	T2277	T2279	arg1Of	and,of
R1899	T2278	T2277	arg2Of	survival,and
R1900	T2282	T2279	arg2Of	types,of
R1901	T2282	T2280	arg1Of	types,many
R1902	T2282	T2281	arg1Of	types,cell
R1903	T2282	T2283	arg1Of	types,including
R1904	T2284	T2283	arg2Of	T-lymphocytes,including
R1905	T2284	T2285	arg1Of	T-lymphocytes,[
R1906	T2286	T2285	arg2Of	15,[
R1907	T2287	T2285	arg3Of	],[
R1908	T2289	T2288	arg1Of	activation,AP-1
R1909	T2289	T2290	arg1Of	activation,requires
R1910	T2289	T2324	arg1Of	activation,regulates
R1911	T2290	T2312	arg1Of	requires,through
R1912	T2290	T2323	arg1Of	requires,and
R1913	T2291	T2292	arg1Of	Fos,(
R1914	T2291	T2301	arg1Of	Fos,and
R1915	T2293	T2294	arg1Of	c-Fos,","
R1916	T2294	T2296	arg1Of	",",","
R1917	T2295	T2294	arg2Of	FosB,","
R1918	T2296	T2292	arg2Of	",",(
R1919	T2296	T2298	arg1Of	",",","
R1920	T2297	T2296	arg2Of	Fra-1,","
R1921	T2299	T2298	arg2Of	Fra-2,","
R1922	T2300	T2292	arg3Of	),(
R1923	T2301	T2290	arg2Of	and,requires
R1924	T2302	T2301	arg2Of	Jun,and
R1925	T2302	T2303	arg1Of	Jun,(
R1926	T2304	T2305	arg1Of	c-Jun,","
R1927	T2305	T2307	arg1Of	",",","
R1928	T2306	T2305	arg2Of	v-Jun,","
R1929	T2307	T2303	arg2Of	",",(
R1930	T2307	T2309	arg1Of	",",","
R1931	T2308	T2307	arg2Of	JunB,","
R1932	T2310	T2309	arg2Of	JunD,","
R1933	T2311	T2303	arg3Of	),(
R1934	T2314	T2312	arg2Of	formation,through
R1935	T2314	T2313	arg1Of	formation,the
R1936	T2314	T2315	arg1Of	formation,of
R1937	T2316	T2317	arg1Of	homo-,and
R1938	T2344	T2339	arg1Of	sites,Both
R1939	T2344	T2340	arg1Of	sites,AP-1
R1940	T2344	T2342	arg1Of	sites,NF-κB
R1941	T2344	T2343	arg1Of	sites,binding
R1942	T2344	T2345	arg1Of	sites,have
R1943	T2344	T2346	arg1Of	sites,been
R1944	T2344	T2347	arg2Of	sites,identified
R1945	T2317	T2315	arg2Of	and,of
R1946	T2347	T2345	arg2Of	identified,have
R1947	T2347	T2346	arg2Of	identified,been
R1948	T2347	T2348	arg1Of	identified,in
R1949	T2318	T2317	arg2Of	hetero-dimers,and
R1950	T2318	T2319	arg1Of	hetero-dimers,[
R1951	T2347	T2356	arg1Of	identified,[
R1952	T2347	T2359	arg1Of	identified,","
R1953	T2320	T2319	arg2Of	"16,17",[
R1954	T2321	T2319	arg3Of	],[
R1955	T2351	T2348	arg2Of	region,in
R1956	T2351	T2349	arg1Of	region,the
R1957	T2351	T2350	arg1Of	region,promoter
R1958	T2351	T2352	arg1Of	region,of
R1959	T2353	T2354	arg1Of	IL-6,and
R1960	T2323	T2322	arg1Of	and,","
R1961	T2354	T2352	arg2Of	and,of
R1962	T2355	T2354	arg2Of	CXCL8,and
R1963	T2357	T2356	arg2Of	"12,22",[
R1964	T2324	T2323	arg2Of	regulates,and
R1965	T2358	T2356	arg3Of	],[
R1966	T2325	T2324	arg2Of	transcription,regulates
R1967	T2325	T2326	arg1Of	transcription,of
R1968	T2363	T2362	arg1Of	mechanism,the
R1969	T2363	T2364	arg2Of	mechanism,by
R1970	T2363	T2365	arg1Of	mechanism,which
R1971	T2363	T2372	arg1Of	mechanism,is
R1972	T2363	T2375	arg1Of	mechanism,clear
R1973	T2329	T2326	arg2Of	range,of
R1974	T2367	T2366	arg1Of	interleukins,these
R1975	T2367	T2368	arg1Of	interleukins,are
R1976	T2367	T2369	arg2Of	interleukins,regulated
R1977	T2369	T2364	arg1Of	regulated,by
R1978	T2369	T2368	arg2Of	regulated,are
R1979	T2369	T2370	arg1Of	regulated,in
R1980	T2371	T2370	arg2Of	T-cells,in
R1981	T2372	T2359	arg2Of	is,","
R1982	T2372	T2360	arg1Of	is,however
R1983	T2372	T2361	arg1Of	is,","
R1984	T2372	T2373	arg1Of	is,still
R1985	T2372	T2374	arg1Of	is,not
R1986	T2375	T2372	arg2Of	clear,is
R1987	T2376	T2377	arg1Of	CXCL8,is
R1988	T2329	T2327	arg1Of	range,a
R1989	T2329	T2328	arg1Of	range,broad
R1990	T2329	T2330	arg1Of	range,of
R1991	T2380	T2377	arg2Of	chemokine,is
R1992	T2380	T2378	arg1Of	chemokine,a
R1993	T2380	T2379	arg1Of	chemokine,C-X-C
R1994	T2380	T2381	arg1Of	chemokine,with
R1995	T2331	T2330	arg2Of	genes,of
R1996	T2382	T2381	arg2Of	properties,with
R1997	T2382	T2383	arg1Of	properties,enabling
R1998	T2384	T2383	arg2Of	it,enabling
R1999	T2384	T2386	arg1Of	it,recruit
R2000	T2384	T2392	arg1Of	it,activate
R2001	T2386	T2385	arg1Of	recruit,to
R2002	T2386	T2390	arg1Of	recruit,and
R2003	T2387	T2388	arg1Of	T-cells,and
R2004	T2331	T2332	arg2Of	genes,involved
R2005	T2388	T2386	arg2Of	and,recruit
R2006	T2332	T2333	arg1Of	involved,in
R2007	T2389	T2388	arg2Of	basophils,and
R2008	T2390	T2383	arg3Of	and,enabling
R2009	T2335	T2333	arg2Of	responses,in
R2010	T2392	T2390	arg2Of	activate,and
R2011	T2392	T2391	arg1Of	activate,to
R2012	T2393	T2394	arg1Of	neutrophils,and
R2013	T2394	T2392	arg2Of	and,activate
R2014	T2394	T2396	arg1Of	and,[
R2015	T2395	T2394	arg2Of	monocytes,and
R2016	T2397	T2396	arg2Of	23,[
R2017	T2335	T2334	arg1Of	responses,immune
R2018	T2398	T2396	arg3Of	],[
R2019	T2335	T2336	arg1Of	responses,[
R2020	T2399	T2400	arg1Of	IL-6,is
R2021	T2337	T2336	arg2Of	18-21,[
R2022	T2338	T2336	arg3Of	],[
R2023	T2400	T2410	arg1Of	is,and
R2024	T2340	T2341	arg1Of	AP-1,and
R2025	T2402	T2400	arg2Of	cytokine,is
R2026	T2402	T2401	arg1Of	cytokine,a
R2027	T2402	T2403	arg1Of	cytokine,that
R2028	T2402	T2404	arg1Of	cytokine,possesses
R2029	T2406	T2407	arg1Of	pro-,and
R2030	T2342	T2341	arg2Of	NF-κB,and
R2031	T2408	T2407	arg2Of	anti-inflammatory,and
R2032	T2409	T2404	arg2Of	characteristics,possesses
R2033	T2409	T2405	arg1Of	characteristics,both
R2034	T2409	T2406	arg1Of	characteristics,pro-
R2035	T2409	T2408	arg1Of	characteristics,anti-inflammatory
R2036	T2411	T2412	arg1Of	that,plays
R2037	T2412	T2410	arg2Of	plays,and
R2038	T2412	T2416	arg1Of	plays,in
R2039	T2412	T2421	arg1Of	plays,[
R2040	T2440	T2441	arg1Of	exposed,to
R2041	T2415	T2412	arg2Of	role,plays
R2042	T2415	T2413	arg1Of	role,a
R2043	T2415	T2414	arg1Of	role,key
R2044	T2417	T2418	arg1Of	haematopoiesis,and
R2045	T2442	T2443	arg1Of	PMA,and
R2046	T2419	T2418	arg2Of	acute-phase,and
R2047	T2420	T2416	arg2Of	responses,in
R2048	T2420	T2417	arg1Of	responses,haematopoiesis
R2049	T2420	T2419	arg1Of	responses,acute-phase
R2050	T2422	T2421	arg2Of	"24,25",[
R2051	T2423	T2421	arg3Of	],[
R2052	T2443	T2441	arg2Of	and,to
R2053	T2426	T2424	arg1Of	study,The
R2054	T2426	T2425	arg1Of	study,present
R2055	T2426	T2427	arg1Of	study,suggests
R2056	T2443	T2452	arg1Of	and,in
R2057	T2444	T2445	arg2Of	heat,killed
R2058	T2430	T2429	arg1Of	regulation,the
R2059	T2430	T2431	arg1Of	regulation,of
R2060	T2430	T2435	arg1Of	regulation,is
R2061	T2430	T2436	arg1Of	regulation,uncoupled
R2062	T2445	T2446	arg1Of	killed,(
R2063	T2432	T2433	arg1Of	CXCL8,and
R2064	T2433	T2431	arg2Of	and,of
R2065	T2434	T2433	arg2Of	IL-6,and
R2066	T2435	T2427	arg2Of	is,suggests
R2067	T2435	T2428	arg1Of	is,that
R2068	T2447	T2446	arg2Of	HK,(
R2069	T2436	T2435	arg2Of	uncoupled,is
R2070	T2448	T2446	arg3Of	),(
R2071	T2439	T2437	arg2Of	T-cells,Using
R2072	T2439	T2438	arg1Of	T-cells,Jurkat
R2073	T2439	T2440	arg2Of	T-cells,exposed
R2074	T2451	T2443	arg2Of	MG1655,and
R2075	T2451	T2444	arg1Of	MG1655,heat
R2076	T2451	T2449	arg1Of	MG1655,Escherichia
R2077	T2451	T2450	arg1Of	MG1655,coli
R2078	T2453	T2452	arg2Of	combination,in
R2079	T2453	T2454	arg1Of	combination,with
R2080	T2455	T2454	arg2Of	inhibitors,with
R2088	T2455	T2456	arg1Of	inhibitors,of
R2089	T2457	T2458	arg1Of	NF-κB,","
R2094	T2458	T2460	arg1Of	",",and
R2097	T2459	T2458	arg2Of	JNK,","
R2098	T2460	T2456	arg2Of	and,of
R2099	T2461	T2460	arg2Of	PKC,and
R2100	T2463	T2437	arg1Of	we,Using
R2101	T2463	T2464	arg1Of	we,demonstrated
R2102	T2464	T2437	modOf	demonstrated,Using
R2103	T2464	T2462	arg1Of	demonstrated,","
R2104	T2466	T2467	arg1Of	NF-κB,regulates
R2105	T2467	T2464	arg2Of	regulates,demonstrated
R2106	T2467	T2465	arg1Of	regulates,that
R2107	T2467	T2470	arg1Of	regulates,while
R2108	T2469	T2467	arg2Of	expression,regulates
R2109	T2469	T2468	arg1Of	expression,IL-6
R2110	T2472	T2471	arg1Of	regulation,the
R2111	T2472	T2473	arg1Of	regulation,of
R2112	T2472	T2477	arg2Of	regulation,correlated
R2113	T2474	T2473	arg2Of	CXCL8,of
R2114	T2476	T2475	arg1Of	closely,more
R2115	T2477	T2470	arg2Of	correlated,while
R2116	T2477	T2476	arg1Of	correlated,closely
R2117	T2477	T2478	arg1Of	correlated,to
R2118	T2480	T2478	arg2Of	activity,to
R2119	T2480	T2479	arg1Of	activity,AP-1
R2120	T2482	T2481	arg1Of	results,These
R2121	T2482	T2483	arg1Of	results,indicate
R2122	T2485	T2486	arg1Of	inhibition,of
R2123	T2485	T2488	arg1Of	inhibition,is
R2124	T2487	T2486	arg2Of	NF-κB,of
R2125	T2488	T2483	arg2Of	is,indicate
R2126	T2488	T2484	arg1Of	is,that
R2127	T2488	T2489	arg1Of	is,not
R2128	T2492	T2488	arg2Of	strategy,is
R2129	T2492	T2490	arg1Of	strategy,an
R2130	T2492	T2491	arg1Of	strategy,effective
R2131	T2492	T2493	arg1Of	strategy,in
R2132	T2494	T2493	arg2Of	countering,in
R2133	T2498	T2494	arg2Of	activities,countering
R2134	T2498	T2495	arg1Of	activities,the
R2135	T2498	T2496	arg1Of	activities,high
R2136	T2498	T2497	arg1Of	activities,CXCL8
R2137	T2498	T2499	arg1Of	activities,in
R2138	T2500	T2499	arg2Of	diseases,in
R2139	T2500	T2502	arg1Of	diseases,as
R2140	T2502	T2501	arg1Of	as,such
R2141	T2504	T2503	arg1Of	fibrosis,cystic
R2142	T2504	T2505	arg1Of	fibrosis,","
R2143	T2505	T2507	arg1Of	",",and
R2144	T2506	T2505	arg2Of	AIDS,","
R2145	T2507	T2502	arg2Of	and,as
R2146	T2509	T2507	arg2Of	fibrosis,and
R2147	T2509	T2508	arg1Of	fibrosis,pulmonary

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T2517	1639-1644	Antecedent	denotes	Fra-1
T2518	1646-1651	Antecedent	denotes	Fra-2
T2519	1657-1660	Anaphor	denotes	Jun
T2520	1662-1667	Antecedent	denotes	c-Jun
T2521	1669-1674	Antecedent	denotes	v-Jun
T2522	1676-1680	Antecedent	denotes	JunB
T2523	1682-1686	Antecedent	denotes	JunD
T2524	1975-1993	Anaphor	denotes	these interleukins
T2525	1919-1923	Antecedent	denotes	IL-6
T2526	1928-1933	Antecedent	denotes	CXCL8
T2510	159-181	Anaphor	denotes	inflammatory mediators
T2511	193-197	Antecedent	denotes	IL-2
T2512	199-203	Antecedent	denotes	IL-6
T2513	213-218	Antecedent	denotes	CXCL8
T2514	1621-1624	Anaphor	denotes	Fos
T2515	1626-1631	Antecedent	denotes	c-Fos
T2516	1633-1637	Antecedent	denotes	FosB
R2086	T2514	T2517	boundBy	Fos,Fra-1
R2087	T2514	T2518	boundBy	Fos,Fra-2
R2090	T2519	T2520	boundBy	Jun,c-Jun
R2091	T2519	T2521	boundBy	Jun,v-Jun
R2092	T2519	T2522	boundBy	Jun,JunB
R2093	T2519	T2523	boundBy	Jun,JunD
R2095	T2524	T2525	boundBy	these interleukins,IL-6
R2096	T2524	T2526	boundBy	these interleukins,CXCL8
R2081	T2510	T2511	boundBy	inflammatory mediators,IL-2
R2082	T2510	T2512	boundBy	inflammatory mediators,IL-6
R2083	T2510	T2513	boundBy	inflammatory mediators,CXCL8
R2084	T2514	T2515	boundBy	Fos,c-Fos
R2085	T2514	T2516	boundBy	Fos,FosB

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T1521	11-20	NNS	denotes	Cytokines
T1522	21-24	CC	denotes	and
T1523	25-35	NNS	denotes	chemokines
T1524	36-39	VBP	denotes	are
T1525	40-49	JJ	denotes	important
T1526	50-52	IN	denotes	in
T1527	53-59	JJ	denotes	immune
T1528	60-64	NN	denotes	cell
T1529	65-76	NN	denotes	recruitment
T1530	77-80	CC	denotes	and
T1531	81-83	IN	denotes	in
T1532	84-94	NN	denotes	regulation
T1533	95-97	IN	denotes	of
T1534	98-110	JJ	denotes	inflammatory
T1536	121-122	VBP	denotes	[
T1537	122-123	CD	denotes	1
T1538	123-124	NNP	denotes	]
T1539	124-125	.	denotes	.
T1540	126-133	NNS	denotes	T-cells
T1541	134-141	VBP	denotes	produce
T1542	142-143	DT	denotes	a
T1543	144-149	JJ	denotes	broad
T1544	150-155	NN	denotes	range
T1545	156-158	IN	denotes	of
T1546	159-171	JJ	denotes	inflammatory
T1547	172-181	NNS	denotes	mediators
T1548	181-182	,	denotes	,
T1549	183-192	VBG	denotes	including
T1550	193-197	NNP	denotes	IL-2
T1551	197-198	,	denotes	,
T1552	199-203	NNP	denotes	IL-6
T1553	203-204	,	denotes	,
T1554	205-208	NNP	denotes	TNF
T1555	209-212	CC	denotes	and
T1556	213-218	NNP	denotes	CXCL8
T1557	218-219	,	denotes	,
T1558	220-223	DT	denotes	all
T1559	224-226	IN	denotes	of
T1560	227-232	WDT	denotes	which
T1561	233-236	VBP	denotes	are
T1562	237-246	JJ	denotes	important
T1563	247-249	IN	denotes	in
T1564	250-254	NN	denotes	cell
T1565	255-268	NN	denotes	proliferation
T1566	268-269	,	denotes	,
T1567	270-285	NN	denotes	differentiation
T1568	285-286	,	denotes	,
T1569	287-300	NN	denotes	communication
T1570	301-304	CC	denotes	and
T1571	305-315	NN	denotes	initiation
T1572	316-318	IN	denotes	of
T1573	319-331	JJ	denotes	inflammatory
T1574	332-341	NNS	denotes	responses
T1575	342-343	VBP	denotes	[
T1576	343-344	CD	denotes	2
T1577	344-345	NNP	denotes	]
T1578	345-346	.	denotes	.
T1579	347-355	JJ	denotes	Elevated
T1580	356-362	NNS	denotes	levels
T1581	363-365	IN	denotes	of
T1582	366-382	JJ	denotes	pro-inflammatory
T1583	383-392	NNS	denotes	cytokines
T1584	393-396	CC	denotes	and
T1585	397-407	NNS	denotes	chemokines
T1586	407-408	,	denotes	,
T1587	409-413	JJ	denotes	such
T1588	414-416	IN	denotes	as
T1589	417-420	NNP	denotes	TNF
T1590	420-421	,	denotes	,
T1591	422-426	NNP	denotes	IL-6
T1592	427-430	CC	denotes	and
T1593	431-436	NNP	denotes	CXCL8
T1594	436-437	,	denotes	,
T1595	438-441	VBP	denotes	are
T1596	442-452	VBN	denotes	associated
T1597	453-457	IN	denotes	with
T1598	458-465	JJ	denotes	several
T1599	466-471	JJ	denotes	human
T1600	472-480	NNS	denotes	diseases
T1601	481-490	VBG	denotes	including
T1602	491-497	JJ	denotes	cystic
T1603	498-506	NN	denotes	fibrosis
T1604	507-508	NNP	denotes	[
T1605	508-511	CD	denotes	3-5
T1606	511-512	NNP	denotes	]
T1607	512-513	,	denotes	,
T1608	514-523	JJ	denotes	pulmonary
T1609	524-532	NN	denotes	fibrosis
T1610	533-534	NNP	denotes	[
T1611	534-537	CD	denotes	6,7
T1612	537-538	NNP	denotes	]
T1613	539-542	CC	denotes	and
T1614	543-547	NNP	denotes	AIDS
T1615	548-549	NNP	denotes	[
T1616	549-552	CD	denotes	8,9
T1617	552-553	NNP	denotes	]
T1618	553-554	.	denotes	.
T1619	555-564	NNP	denotes	Induction
T1620	565-567	IN	denotes	of
T1621	568-573	NNP	denotes	CXCL8
T1622	574-577	VBZ	denotes	has
T1623	578-582	VBN	denotes	been
T1624	583-592	VBN	denotes	suggested
T1625	593-595	TO	denotes	to
T1626	596-598	VB	denotes	be
T1627	599-607	VBN	denotes	mediated
T1628	608-615	IN	denotes	through
T1629	616-621	NN	denotes	NF-κB
T1630	622-624	IN	denotes	in
T1631	625-636	NN	denotes	cooperation
T1632	637-641	IN	denotes	with
T1633	642-646	NNP	denotes	AP-1
T1634	647-648	NNP	denotes	[
T1635	648-653	CD	denotes	10,11
T1636	653-654	NNP	denotes	]
T1637	654-655	,	denotes	,
T1638	656-663	RB	denotes	however
T1639	664-667	DT	denotes	the
T1640	668-675	JJ	denotes	precise
T1641	676-685	NN	denotes	mechanism
T1642	686-688	VBZ	denotes	is
T1643	689-692	RB	denotes	not
T1644	693-698	RB	denotes	fully
T1645	699-709	VBN	denotes	elucidated
T1646	709-710	,	denotes	,
T1647	711-714	CC	denotes	and
T1648	715-724	NN	denotes	treatment
T1649	725-735	NNS	denotes	strategies
T1650	736-741	VBN	denotes	aimed
T1651	742-744	IN	denotes	at
T1652	745-755	VBG	denotes	inhibiting
T1653	756-761	CD	denotes	CXCL8
T1654	762-766	VBP	denotes	have
T1655	767-773	VBN	denotes	failed
T1656	774-775	NNP	denotes	[
T1657	775-777	CD	denotes	12
T1658	777-778	NNP	denotes	]
T1659	778-779	.	denotes	.
T1660	780-790	JJ	denotes	Persistent
T1661	791-801	NN	denotes	production
T1662	802-804	IN	denotes	of
T1663	805-809	NNP	denotes	IL-6
T1664	810-813	CC	denotes	and
T1665	814-819	NNP	denotes	CXCL8
T1666	820-825	VBZ	denotes	leads
T1667	826-828	TO	denotes	to
T1668	829-836	JJ	denotes	chronic
T1669	837-849	NN	denotes	inflammation
T1670	850-853	CC	denotes	and
T1671	854-862	JJ	denotes	enhanced
T1672	863-871	NN	denotes	survival
T1673	872-874	IN	denotes	of
T1674	875-886	NNS	denotes	lymphocytes
T1675	887-897	VBG	denotes	increasing
T1676	898-903	NN	denotes	serum
T1677	904-922	NN	denotes	cytokine/chemokine
T1678	923-929	NNS	denotes	levels
T1679	929-930	.	denotes	.
T1680	931-935	DT	denotes	This
T1681	936-941	VBZ	denotes	forms
T1682	942-945	DT	denotes	the
T1683	946-951	NN	denotes	basis
T1684	952-954	IN	denotes	of
T1685	955-962	JJ	denotes	several
T1686	963-973	JJ	denotes	autoimmune
T1687	974-983	NNS	denotes	disorders
T1688	984-993	VBG	denotes	including
T1689	994-1007	NN	denotes	plasmacytosis
T1690	1008-1011	CC	denotes	and
T1691	1012-1023	NN	denotes	hyperplasia
T1692	1024-1025	NNP	denotes	[
T1693	1025-1027	CD	denotes	13
T1694	1027-1028	NNP	denotes	]
T1695	1028-1029	.	denotes	.
T1696	1030-1032	TO	denotes	To
T1697	1033-1040	VB	denotes	develop
T1698	1041-1047	JJ	denotes	viable
T1699	1048-1053	NNP	denotes	CXCL8
T1700	1054-1059	VBN	denotes	based
T1701	1060-1069	NN	denotes	treatment
T1702	1070-1080	NNS	denotes	strategies
T1703	1080-1081	,	denotes	,
T1704	1082-1084	PRP	denotes	it
T1705	1085-1087	VBZ	denotes	is
T1706	1088-1097	JJ	denotes	necessary
T1707	1098-1100	TO	denotes	to
T1708	1101-1109	VB	denotes	identify
T1709	1110-1113	DT	denotes	the
T1710	1114-1124	JJ	denotes	signalling
T1711	1125-1133	NNS	denotes	pathways
T1712	1134-1144	VBG	denotes	regulating
T1713	1145-1150	NNP	denotes	CXCL8
T1714	1151-1154	CC	denotes	and
T1715	1155-1164	VB	denotes	determine
T1716	1165-1168	WRB	denotes	how
T1717	1169-1173	DT	denotes	this
T1718	1174-1176	VBZ	denotes	is
T1719	1177-1184	VBN	denotes	coupled
T1720	1185-1187	TO	denotes	to
T1721	1188-1193	NNP	denotes	NF-κB
T1722	1193-1194	,	denotes	,
T1723	1195-1199	NNP	denotes	AP-1
T1724	1200-1203	CC	denotes	and
T1725	1204-1208	NNP	denotes	IL-6
T1726	1208-1209	.	denotes	.
T1727	1210-1213	DT	denotes	The
T1728	1214-1224	JJ	denotes	signalling
T1729	1225-1233	NNS	denotes	pathways
T1730	1234-1241	VBG	denotes	leading
T1731	1242-1244	TO	denotes	to
T1732	1245-1250	NNP	denotes	NF-κB
T1733	1251-1254	CC	denotes	and
T1734	1255-1259	NNP	denotes	AP-1
T1735	1260-1270	NN	denotes	activation
T1736	1271-1274	VBP	denotes	are
T1737	1275-1286	VBG	denotes	overlapping
T1738	1286-1287	,	denotes	,
T1739	1288-1293	WRB	denotes	where
T1740	1294-1298	DT	denotes	both
T1741	1299-1302	VBP	denotes	are
T1742	1303-1311	VBN	denotes	involved
T1743	1312-1314	IN	denotes	in
T1744	1315-1318	DT	denotes	the
T1745	1319-1328	NN	denotes	induction
T1746	1329-1332	CC	denotes	and
T1747	1333-1343	NN	denotes	regulation
T1748	1344-1346	IN	denotes	of
T1749	1347-1367	NNS	denotes	cytokines/chemokines
T1750	1367-1368	.	denotes	.
T1751	1369-1374	NN	denotes	NF-κB
T1752	1375-1377	VBZ	denotes	is
T1753	1378-1387	VBN	denotes	activated
T1754	1388-1390	IN	denotes	in
T1755	1391-1399	NN	denotes	response
T1756	1400-1402	TO	denotes	to
T1757	1403-1409	NN	denotes	stress
T1758	1409-1410	,	denotes	,
T1759	1411-1415	JJ	denotes	such
T1760	1416-1418	IN	denotes	as
T1761	1419-1428	JJ	denotes	oxidative
T1762	1429-1435	NN	denotes	stress
T1763	1435-1436	,	denotes	,
T1764	1437-1446	JJ	denotes	bacterial
T1765	1447-1453	NNS	denotes	toxins
T1766	1453-1454	,	denotes	,
T1767	1455-1462	NNS	denotes	viruses
T1768	1463-1466	CC	denotes	and
T1769	1467-1469	NNP	denotes	UV
T1770	1470-1475	JJ	denotes	light
T1771	1476-1477	NNP	denotes	[
T1772	1477-1479	CD	denotes	14
T1773	1479-1480	NNP	denotes	]
T1774	1480-1481	,	denotes	,
T1775	1482-1485	CC	denotes	and
T1776	1486-1488	VBZ	denotes	is
T1777	1489-1498	JJ	denotes	essential
T1778	1499-1502	IN	denotes	for
T1779	1503-1518	NN	denotes	differentiation
T1780	1518-1519	,	denotes	,
T1781	1520-1533	NN	denotes	proliferation
T1782	1534-1537	CC	denotes	and
T1783	1538-1546	NN	denotes	survival
T1784	1547-1549	IN	denotes	of
T1785	1550-1554	JJ	denotes	many
T1786	1555-1559	NN	denotes	cell
T1787	1560-1565	NNS	denotes	types
T1788	1566-1575	VBG	denotes	including
T1789	1576-1589	NNS	denotes	T-lymphocytes
T1790	1590-1591	NNP	denotes	[
T1791	1591-1593	CD	denotes	15
T1792	1593-1594	NNP	denotes	]
T1793	1594-1595	.	denotes	.
T1794	1596-1600	CD	denotes	AP-1
T1795	1601-1611	NN	denotes	activation
T1796	1612-1620	VBZ	denotes	requires
T1797	1621-1624	NNP	denotes	Fos
T1798	1625-1626	-LRB-	denotes	(
T1799	1626-1631	NNP	denotes	c-Fos
T1800	1631-1632	,	denotes	,
T1801	1633-1637	NNP	denotes	FosB
T1802	1637-1638	,	denotes	,
T1803	1639-1644	NNP	denotes	Fra-1
T1804	1644-1645	,	denotes	,
T1805	1646-1651	NNP	denotes	Fra-2
T1806	1651-1652	-RRB-	denotes	)
T1807	1653-1656	CC	denotes	and
T1808	1657-1660	NNP	denotes	Jun
T1809	1661-1662	-LRB-	denotes	(
T1810	1662-1667	NNP	denotes	c-Jun
T1811	1667-1668	,	denotes	,
T1812	1669-1674	NNP	denotes	v-Jun
T1813	1674-1675	,	denotes	,
T1814	1676-1680	NNP	denotes	JunB
T1815	1680-1681	,	denotes	,
T1816	1682-1686	NNP	denotes	JunD
T1817	1686-1687	-RRB-	denotes	)
T1818	1688-1695	IN	denotes	through
T1819	1696-1699	DT	denotes	the
T1820	1700-1709	NN	denotes	formation
T1821	1710-1712	IN	denotes	of
T1822	1713-1717	NN	denotes	homo
T1823	1717-1718	:	denotes	-
T1824	1719-1722	CC	denotes	and
T1825	1723-1736	NNS	denotes	hetero-dimers
T1826	1737-1738	NNP	denotes	[
T1827	1738-1743	CD	denotes	16,17
T1828	1743-1744	NNP	denotes	]
T1829	1744-1745	,	denotes	,
T1830	1746-1749	CC	denotes	and
T1831	1750-1759	VBZ	denotes	regulates
T1832	1760-1773	NN	denotes	transcription
T1833	1774-1776	IN	denotes	of
T1834	1777-1778	DT	denotes	a
T1835	1779-1784	JJ	denotes	broad
T1836	1785-1790	NN	denotes	range
T1837	1791-1793	IN	denotes	of
T1838	1794-1799	NNS	denotes	genes
T1839	1800-1808	VBN	denotes	involved
T1840	1809-1811	IN	denotes	in
T1841	1812-1818	JJ	denotes	immune
T1842	1819-1828	NNS	denotes	responses
T1843	1829-1830	NNP	denotes	[
T1844	1830-1835	CD	denotes	18-21
T1845	1835-1836	NNP	denotes	]
T1846	1836-1837	.	denotes	.
T1847	1838-1842	DT	denotes	Both
T1848	1843-1847	JJ	denotes	AP-1
T1849	1848-1851	CC	denotes	and
T1850	1852-1857	JJ	denotes	NF-κB
T1851	1858-1865	JJ	denotes	binding
T1852	1866-1871	NNS	denotes	sites
T1853	1872-1876	VBP	denotes	have
T1854	1877-1881	VBN	denotes	been
T1855	1882-1892	VBN	denotes	identified
T1856	1893-1895	IN	denotes	in
T1857	1896-1899	DT	denotes	the
T1858	1900-1908	NN	denotes	promoter
T1859	1909-1915	NN	denotes	region
T1860	1916-1918	IN	denotes	of
T1861	1919-1923	NNP	denotes	IL-6
T1862	1924-1927	CC	denotes	and
T1863	1928-1933	NNP	denotes	CXCL8
T1864	1934-1935	NNP	denotes	[
T1865	1935-1940	CD	denotes	12,22
T1866	1940-1941	NNP	denotes	]
T1867	1941-1942	,	denotes	,
T1868	1943-1950	RB	denotes	however
T1869	1950-1951	,	denotes	,
T1870	1952-1955	DT	denotes	the
T1871	1956-1965	NN	denotes	mechanism
T1872	1966-1968	IN	denotes	by
T1873	1969-1974	WDT	denotes	which
T1874	1975-1980	DT	denotes	these
T1875	1981-1993	NNS	denotes	interleukins
T1876	1994-1997	VBP	denotes	are
T1877	1998-2007	VBN	denotes	regulated
T1878	2008-2010	IN	denotes	in
T1879	2011-2018	NNS	denotes	T-cells
T1880	2019-2021	VBZ	denotes	is
T1881	2022-2027	RB	denotes	still
T1882	2028-2031	RB	denotes	not
T1883	2032-2037	JJ	denotes	clear
T1884	2037-2038	.	denotes	.
T1885	2039-2044	CD	denotes	CXCL8
T1886	2045-2047	VBZ	denotes	is
T1887	2048-2049	DT	denotes	a
T1888	2050-2055	JJ	denotes	C-X-C
T1889	2056-2065	NN	denotes	chemokine
T1890	2066-2070	IN	denotes	with
T1891	2071-2081	NNS	denotes	properties
T1892	2082-2090	VBG	denotes	enabling
T1893	2091-2093	PRP	denotes	it
T1894	2094-2096	TO	denotes	to
T1895	2097-2104	VB	denotes	recruit
T1896	2105-2112	NNS	denotes	T-cells
T1897	2113-2116	CC	denotes	and
T1898	2117-2126	NNS	denotes	basophils
T1899	2127-2130	CC	denotes	and
T1900	2131-2133	TO	denotes	to
T1901	2134-2142	VB	denotes	activate
T1902	2143-2154	NNS	denotes	neutrophils
T1903	2155-2158	CC	denotes	and
T1904	2159-2168	NNS	denotes	monocytes
T1905	2169-2170	NNP	denotes	[
T1906	2170-2172	CD	denotes	23
T1907	2172-2173	NNP	denotes	]
T1908	2173-2174	.	denotes	.
T1909	2175-2179	NN	denotes	IL-6
T1910	2180-2182	VBZ	denotes	is
T1911	2183-2184	DT	denotes	a
T1912	2185-2193	NN	denotes	cytokine
T1913	2194-2198	WDT	denotes	that
T1914	2199-2208	VBZ	denotes	possesses
T1915	2209-2213	DT	denotes	both
T1916	2214-2218	JJ	denotes	pro-
T1917	2219-2222	CC	denotes	and
T1918	2223-2240	JJ	denotes	anti-inflammatory
T1919	2241-2256	NNS	denotes	characteristics
T1920	2257-2260	CC	denotes	and
T1921	2261-2265	IN	denotes	that
T1922	2266-2271	VBZ	denotes	plays
T1923	2272-2273	DT	denotes	a
T1924	2274-2277	JJ	denotes	key
T1925	2278-2282	NN	denotes	role
T1926	2283-2285	IN	denotes	in
T1927	2286-2300	NN	denotes	haematopoiesis
T1928	2301-2304	CC	denotes	and
T1929	2305-2316	JJ	denotes	acute-phase
T1930	2317-2326	NNS	denotes	responses
T1931	2327-2328	NNP	denotes	[
T1932	2328-2333	CD	denotes	24,25
T1933	2333-2334	NNP	denotes	]
T1934	2334-2335	.	denotes	.
T1935	2336-2339	DT	denotes	The
T1936	2340-2347	JJ	denotes	present
T1937	2348-2353	NN	denotes	study
T1938	2354-2362	VBZ	denotes	suggests
T1939	2363-2367	IN	denotes	that
T1940	2368-2371	DT	denotes	the
T1941	2372-2382	NN	denotes	regulation
T1942	2383-2385	IN	denotes	of
T1943	2386-2391	NNP	denotes	CXCL8
T1944	2392-2395	CC	denotes	and
T1945	2396-2400	NNP	denotes	IL-6
T1946	2401-2403	VBZ	denotes	is
T1947	2404-2413	JJ	denotes	uncoupled
T1948	2413-2414	.	denotes	.
T1949	2415-2420	VBG	denotes	Using
T1950	2421-2427	NNP	denotes	Jurkat
T1951	2428-2435	NNS	denotes	T-cells
T1952	2436-2443	VBN	denotes	exposed
T1953	2444-2446	TO	denotes	to
T1954	2447-2450	NNP	denotes	PMA
T1955	2451-2454	CC	denotes	and
T1956	2455-2459	NN	denotes	heat
T1957	2460-2466	VBN	denotes	killed
T1958	2467-2468	-LRB-	denotes	(
T1959	2468-2470	NNP	denotes	HK
T1960	2470-2471	-RRB-	denotes	)
T1961	2472-2483	NNP	denotes	Escherichia
T1962	2484-2488	NNS	denotes	coli
T1963	2489-2495	NNP	denotes	MG1655
T1964	2496-2498	IN	denotes	in
T1965	2499-2510	NN	denotes	combination
T1966	2511-2515	IN	denotes	with
T1967	2516-2526	NNS	denotes	inhibitors
T1968	2527-2529	IN	denotes	of
T1969	2530-2535	NNP	denotes	NF-κB
T1970	2535-2536	,	denotes	,
T1971	2537-2540	NNP	denotes	JNK
T1972	2541-2544	CC	denotes	and
T1973	2545-2548	NNP	denotes	PKC
T1974	2548-2549	,	denotes	,
T1975	2550-2552	PRP	denotes	we
T1976	2553-2565	VBD	denotes	demonstrated
T1977	2566-2570	IN	denotes	that
T1978	2571-2576	JJ	denotes	NF-κB
T1979	2577-2586	VBZ	denotes	regulates
T1980	2587-2591	NNP	denotes	IL-6
T1981	2592-2602	NN	denotes	expression
T1982	2603-2608	IN	denotes	while
T1983	2609-2612	DT	denotes	the
T1984	2613-2623	NN	denotes	regulation
T1985	2624-2626	IN	denotes	of
T1986	2627-2632	CD	denotes	CXCL8
T1987	2633-2637	JJR	denotes	more
T1988	2638-2645	RB	denotes	closely
T1989	2646-2656	JJ	denotes	correlated
T1990	2657-2659	TO	denotes	to
T1991	2660-2664	JJ	denotes	AP-1
T1992	2665-2673	NN	denotes	activity
T1993	2673-2674	.	denotes	.
T1994	2675-2680	DT	denotes	These
T1995	2681-2688	NNS	denotes	results
T1996	2689-2697	VBP	denotes	indicate
T1997	2698-2702	IN	denotes	that
T1998	2703-2713	NN	denotes	inhibition
T1999	2714-2716	IN	denotes	of
T2000	2717-2722	NNP	denotes	NF-κB
T2001	2723-2725	VBZ	denotes	is
T2002	2726-2729	RB	denotes	not
T2003	2730-2732	DT	denotes	an
T2004	2733-2742	JJ	denotes	effective
T2005	2743-2751	NN	denotes	strategy
T2006	2752-2754	IN	denotes	in
T2007	2755-2765	VBG	denotes	countering
T2008	2766-2769	DT	denotes	the
T2009	2770-2774	JJ	denotes	high
T2010	2775-2780	CD	denotes	CXCL8
T2011	2781-2791	NNS	denotes	activities
T2012	2792-2794	IN	denotes	in
T2013	2795-2803	NNS	denotes	diseases
T2014	2804-2808	JJ	denotes	such
T2015	2809-2811	IN	denotes	as
T2016	2812-2818	JJ	denotes	cystic
T2017	2819-2827	NN	denotes	fibrosis
T2018	2827-2828	,	denotes	,
T2019	2829-2833	NNP	denotes	AIDS
T2020	2834-2837	CC	denotes	and
T2021	2838-2847	JJ	denotes	pulmonary
T2022	2848-2856	NN	denotes	fibrosis
T2023	2856-2857	.	denotes	.
T1535	111-120	NNS	denotes	responses
R1131	T1521	T1524	nsubj	Cytokines,are
R1132	T1522	T1521	cc	and,Cytokines
R1133	T1523	T1521	conj	chemokines,Cytokines
R1134	T1524	T1524	ROOT	are,are
R1135	T1525	T1524	acomp	important,are
R1136	T1526	T1525	prep	in,important
R1137	T1527	T1529	amod	immune,recruitment
R1138	T1528	T1529	compound	cell,recruitment
R1139	T1529	T1526	pobj	recruitment,in
R1140	T1530	T1526	cc	and,in
R1141	T1531	T1526	conj	in,in
R1142	T1532	T1531	pobj	regulation,in
R1143	T1533	T1532	prep	of,regulation
R1144	T1534	T1535	amod	inflammatory,responses
R1145	T1535	T1533	pobj	responses,of
R1146	T1536	T1538	nmod	[,]
R1147	T1537	T1538	nummod	1,]
R1148	T1538	T1524	npadvmod	],are
R1149	T1539	T1524	punct	.,are
R1150	T1540	T1541	nsubj	T-cells,produce
R1151	T1541	T1541	ROOT	produce,produce
R1152	T1542	T1544	det	a,range
R1153	T1543	T1544	amod	broad,range
R1154	T1544	T1541	dobj	range,produce
R1155	T1545	T1544	prep	of,range
R1156	T1546	T1547	amod	inflammatory,mediators
R1157	T1547	T1545	pobj	mediators,of
R1158	T1548	T1547	punct	",",mediators
R1159	T1549	T1547	prep	including,mediators
R1160	T1550	T1549	pobj	IL-2,including
R1161	T1551	T1550	punct	",",IL-2
R1162	T1552	T1550	conj	IL-6,IL-2
R1163	T1553	T1552	punct	",",IL-6
R1164	T1554	T1552	conj	TNF,IL-6
R1165	T1555	T1554	cc	and,TNF
R1166	T1556	T1554	conj	CXCL8,TNF
R1167	T1557	T1556	punct	",",CXCL8
R1168	T1558	T1561	nsubj	all,are
R1169	T1559	T1558	prep	of,all
R1170	T1560	T1559	pobj	which,of
R1171	T1561	T1541	conj	are,produce
R1172	T1562	T1561	acomp	important,are
R1173	T1563	T1561	prep	in,are
R1174	T1564	T1565	compound	cell,proliferation
R1175	T1565	T1563	pobj	proliferation,in
R1176	T1566	T1565	punct	",",proliferation
R1177	T1567	T1565	conj	differentiation,proliferation
R1178	T1568	T1567	punct	",",differentiation
R1179	T1569	T1567	conj	communication,differentiation
R1180	T1570	T1569	cc	and,communication
R1181	T1571	T1569	conj	initiation,communication
R1182	T1572	T1571	prep	of,initiation
R1183	T1573	T1574	amod	inflammatory,responses
R1184	T1574	T1572	pobj	responses,of
R1185	T1575	T1561	conj	[,are
R1186	T1576	T1577	nummod	2,]
R1187	T1577	T1575	dobj	],[
R1188	T1578	T1561	punct	.,are
R1189	T1579	T1580	amod	Elevated,levels
R1190	T1580	T1596	nsubjpass	levels,associated
R1191	T1581	T1580	prep	of,levels
R1192	T1582	T1583	amod	pro-inflammatory,cytokines
R1193	T1583	T1581	pobj	cytokines,of
R1194	T1584	T1583	cc	and,cytokines
R1195	T1585	T1583	conj	chemokines,cytokines
R1196	T1586	T1585	punct	",",chemokines
R1197	T1587	T1588	amod	such,as
R1198	T1588	T1585	prep	as,chemokines
R1199	T1589	T1588	pobj	TNF,as
R1200	T1590	T1589	punct	",",TNF
R1201	T1591	T1589	conj	IL-6,TNF
R1202	T1592	T1591	cc	and,IL-6
R1203	T1593	T1591	conj	CXCL8,IL-6
R1204	T1594	T1596	punct	",",associated
R1205	T1595	T1596	auxpass	are,associated
R1206	T1596	T1596	ROOT	associated,associated
R1207	T1597	T1596	prep	with,associated
R1208	T1598	T1600	amod	several,diseases
R1209	T1599	T1600	amod	human,diseases
R1210	T1600	T1597	pobj	diseases,with
R1211	T1601	T1600	prep	including,diseases
R1212	T1602	T1603	compound	cystic,fibrosis
R1213	T1603	T1606	compound	fibrosis,]
R1214	T1604	T1606	compound	[,]
R1215	T1605	T1606	compound	3-5,]
R1216	T1606	T1601	pobj	],including
R1217	T1607	T1606	punct	",",]
R1218	T1608	T1609	amod	pulmonary,fibrosis
R1219	T1609	T1612	nmod	fibrosis,]
R1220	T1610	T1612	compound	[,]
R1221	T1611	T1612	compound	"6,7",]
R1222	T1612	T1606	conj	],]
R1223	T1613	T1612	cc	and,]
R1224	T1614	T1615	compound	AIDS,[
R1225	T1615	T1612	conj	[,]
R1226	T1616	T1617	compound	"8,9",]
R1227	T1617	T1612	conj	],]
R1228	T1618	T1596	punct	.,associated
R1229	T1619	T1624	nsubjpass	Induction,suggested
R1230	T1620	T1619	prep	of,Induction
R1231	T1621	T1620	pobj	CXCL8,of
R1232	T1622	T1624	aux	has,suggested
R1233	T1623	T1624	auxpass	been,suggested
R1234	T1624	T1624	ROOT	suggested,suggested
R1235	T1625	T1627	aux	to,mediated
R1236	T1626	T1627	auxpass	be,mediated
R1237	T1627	T1624	xcomp	mediated,suggested
R1238	T1628	T1627	prep	through,mediated
R1239	T1629	T1628	pobj	NF-κB,through
R1240	T1630	T1627	prep	in,mediated
R1241	T1631	T1630	pobj	cooperation,in
R1242	T1632	T1631	prep	with,cooperation
R1243	T1633	T1634	compound	AP-1,[
R1244	T1634	T1632	pobj	[,with
R1245	T1635	T1636	nummod	"10,11",]
R1246	T1636	T1624	nsubj	],suggested
R1247	T1637	T1624	punct	",",suggested
R1248	T1638	T1642	advmod	however,is
R1249	T1639	T1641	det	the,mechanism
R1250	T1640	T1641	amod	precise,mechanism
R1251	T1641	T1642	nsubj	mechanism,is
R1252	T1642	T1645	auxpass	is,elucidated
R1253	T1643	T1645	neg	not,elucidated
R1254	T1644	T1645	advmod	fully,elucidated
R1255	T1645	T1624	conj	elucidated,suggested
R1256	T1646	T1645	punct	",",elucidated
R1257	T1647	T1645	cc	and,elucidated
R1258	T1648	T1649	compound	treatment,strategies
R1259	T1649	T1655	nsubj	strategies,failed
R1260	T1650	T1649	acl	aimed,strategies
R1261	T1651	T1650	prep	at,aimed
R1262	T1652	T1651	pcomp	inhibiting,at
R1263	T1653	T1652	dobj	CXCL8,inhibiting
R1264	T1654	T1655	aux	have,failed
R1265	T1655	T1645	conj	failed,elucidated
R1266	T1656	T1658	nmod	[,]
R1267	T1657	T1658	nummod	12,]
R1268	T1658	T1655	dobj	],failed
R1269	T1659	T1624	punct	.,suggested
R1270	T1660	T1661	amod	Persistent,production
R1271	T1661	T1666	nsubj	production,leads
R1272	T1662	T1661	prep	of,production
R1273	T1663	T1662	pobj	IL-6,of
R1274	T1664	T1663	cc	and,IL-6
R1275	T1665	T1663	conj	CXCL8,IL-6
R1276	T1666	T1666	ROOT	leads,leads
R1277	T1667	T1666	prep	to,leads
R1278	T1668	T1669	amod	chronic,inflammation
R1279	T1669	T1667	pobj	inflammation,to
R1280	T1670	T1669	cc	and,inflammation
R1281	T1671	T1672	amod	enhanced,survival
R1282	T1672	T1669	conj	survival,inflammation
R1283	T1673	T1669	prep	of,inflammation
R1284	T1674	T1673	pobj	lymphocytes,of
R1285	T1675	T1666	advcl	increasing,leads
R1286	T1676	T1678	nmod	serum,levels
R1287	T1677	T1678	compound	cytokine/chemokine,levels
R1288	T1678	T1675	dobj	levels,increasing
R1289	T1679	T1666	punct	.,leads
R1290	T1680	T1681	nsubj	This,forms
R1291	T1681	T1681	ROOT	forms,forms
R1292	T1682	T1683	det	the,basis
R1293	T1683	T1681	dobj	basis,forms
R1294	T1684	T1683	prep	of,basis
R1295	T1685	T1687	amod	several,disorders
R1296	T1686	T1687	amod	autoimmune,disorders
R1297	T1687	T1684	pobj	disorders,of
R1298	T1688	T1687	prep	including,disorders
R1299	T1689	T1688	pobj	plasmacytosis,including
R1300	T1690	T1689	cc	and,plasmacytosis
R1301	T1691	T1689	conj	hyperplasia,plasmacytosis
R1302	T1692	T1694	quantmod	[,]
R1303	T1693	T1694	nummod	13,]
R1304	T1694	T1689	conj	],plasmacytosis
R1305	T1695	T1681	punct	.,forms
R1306	T1696	T1697	aux	To,develop
R1307	T1697	T1705	advcl	develop,is
R1308	T1698	T1702	amod	viable,strategies
R1309	T1699	T1700	npadvmod	CXCL8,based
R1310	T1700	T1702	amod	based,strategies
R1311	T1701	T1702	compound	treatment,strategies
R1312	T1702	T1697	dobj	strategies,develop
R1313	T1703	T1705	punct	",",is
R1314	T1704	T1705	nsubj	it,is
R1315	T1705	T1705	ROOT	is,is
R1316	T1706	T1705	acomp	necessary,is
R1317	T1707	T1708	aux	to,identify
R1318	T1708	T1705	xcomp	identify,is
R1319	T1709	T1711	det	the,pathways
R1320	T1710	T1711	amod	signalling,pathways
R1321	T1711	T1708	dobj	pathways,identify
R1322	T1712	T1711	acl	regulating,pathways
R1323	T1713	T1712	dobj	CXCL8,regulating
R1324	T1714	T1708	cc	and,identify
R1325	T1715	T1708	conj	determine,identify
R1326	T1716	T1719	advmod	how,coupled
R1327	T1717	T1719	nsubjpass	this,coupled
R1328	T1718	T1719	auxpass	is,coupled
R1329	T1719	T1715	ccomp	coupled,determine
R1330	T1720	T1719	prep	to,coupled
R1331	T1721	T1720	pobj	NF-κB,to
R1332	T1722	T1721	punct	",",NF-κB
R1333	T1723	T1721	conj	AP-1,NF-κB
R1334	T1724	T1723	cc	and,AP-1
R1335	T1725	T1723	conj	IL-6,AP-1
R1336	T1726	T1705	punct	.,is
R1337	T1727	T1729	det	The,pathways
R1338	T1728	T1729	amod	signalling,pathways
R1339	T1729	T1737	nsubj	pathways,overlapping
R1340	T1730	T1729	acl	leading,pathways
R1341	T1731	T1730	prep	to,leading
R1342	T1732	T1731	pobj	NF-κB,to
R1343	T1733	T1732	cc	and,NF-κB
R1344	T1734	T1735	compound	AP-1,activation
R1345	T1735	T1732	conj	activation,NF-κB
R1346	T1736	T1737	aux	are,overlapping
R1347	T1737	T1737	ROOT	overlapping,overlapping
R1348	T1738	T1737	punct	",",overlapping
R1349	T1739	T1742	advmod	where,involved
R1350	T1740	T1742	nsubjpass	both,involved
R1351	T1741	T1742	auxpass	are,involved
R1352	T1742	T1737	advcl	involved,overlapping
R1353	T1743	T1742	prep	in,involved
R1354	T1744	T1745	det	the,induction
R1355	T1745	T1743	pobj	induction,in
R1356	T1746	T1745	cc	and,induction
R1357	T1747	T1745	conj	regulation,induction
R1358	T1748	T1745	prep	of,induction
R1359	T1749	T1748	pobj	cytokines/chemokines,of
R1360	T1750	T1737	punct	.,overlapping
R1361	T1751	T1753	nsubjpass	NF-κB,activated
R1362	T1752	T1753	auxpass	is,activated
R1363	T1753	T1753	ROOT	activated,activated
R1364	T1754	T1753	prep	in,activated
R1365	T1755	T1754	pobj	response,in
R1366	T1756	T1755	prep	to,response
R1367	T1757	T1756	pobj	stress,to
R1368	T1758	T1753	punct	",",activated
R1369	T1759	T1760	amod	such,as
R1370	T1760	T1753	prep	as,activated
R1371	T1761	T1762	amod	oxidative,stress
R1372	T1762	T1760	pobj	stress,as
R1373	T1763	T1762	punct	",",stress
R1374	T1764	T1765	amod	bacterial,toxins
R1375	T1765	T1762	conj	toxins,stress
R1376	T1766	T1765	punct	",",toxins
R1377	T1767	T1765	conj	viruses,toxins
R1378	T1768	T1767	cc	and,viruses
R1379	T1769	T1767	conj	UV,viruses
R1380	T1770	T1773	amod	light,]
R1381	T1771	T1773	nmod	[,]
R1382	T1772	T1773	nummod	14,]
R1383	T1773	T1769	conj	],UV
R1384	T1774	T1769	punct	",",UV
R1385	T1775	T1753	cc	and,activated
R1386	T1776	T1753	conj	is,activated
R1387	T1777	T1776	acomp	essential,is
R1388	T1778	T1776	prep	for,is
R1389	T1779	T1778	pobj	differentiation,for
R1390	T1780	T1779	punct	",",differentiation
R1391	T1781	T1779	conj	proliferation,differentiation
R1392	T1782	T1781	cc	and,proliferation
R1393	T1783	T1781	conj	survival,proliferation
R1394	T1784	T1779	prep	of,differentiation
R1395	T1785	T1787	amod	many,types
R1396	T1786	T1787	compound	cell,types
R1397	T1787	T1784	pobj	types,of
R1398	T1788	T1787	prep	including,types
R1399	T1789	T1790	compound	T-lymphocytes,[
R1400	T1790	T1788	pobj	[,including
R1401	T1791	T1792	nummod	15,]
R1402	T1792	T1790	appos	],[
R1403	T1793	T1753	punct	.,activated
R1404	T1794	T1795	nummod	AP-1,activation
R1405	T1795	T1796	nsubj	activation,requires
R1406	T1796	T1796	ROOT	requires,requires
R1407	T1797	T1796	dobj	Fos,requires
R1408	T1798	T1799	punct	(,c-Fos
R1409	T1799	T1797	appos	c-Fos,Fos
R1410	T1800	T1799	punct	",",c-Fos
R1411	T1801	T1799	conj	FosB,c-Fos
R1412	T1802	T1801	punct	",",FosB
R1413	T1803	T1801	conj	Fra-1,FosB
R1414	T1804	T1803	punct	",",Fra-1
R1415	T1805	T1803	conj	Fra-2,Fra-1
R1416	T1806	T1805	punct	),Fra-2
R1417	T1807	T1803	cc	and,Fra-1
R1418	T1808	T1803	conj	Jun,Fra-1
R1419	T1809	T1810	punct	(,c-Jun
R1420	T1810	T1803	conj	c-Jun,Fra-1
R1421	T1811	T1810	punct	",",c-Jun
R1422	T1812	T1810	conj	v-Jun,c-Jun
R1423	T1813	T1812	punct	",",v-Jun
R1424	T1814	T1812	conj	JunB,v-Jun
R1425	T1815	T1814	punct	",",JunB
R1426	T1816	T1814	conj	JunD,JunB
R1427	T1817	T1797	punct	),Fos
R1428	T1818	T1796	prep	through,requires
R1429	T1819	T1820	det	the,formation
R1430	T1820	T1818	pobj	formation,through
R1431	T1821	T1820	prep	of,formation
R1432	T1822	T1821	pobj	homo,of
R1433	T1823	T1820	punct	-,formation
R1434	T1824	T1820	cc	and,formation
R1435	T1825	T1828	compound	hetero-dimers,]
R1436	T1826	T1828	compound	[,]
R1437	T1827	T1828	compound	"16,17",]
R1438	T1828	T1820	conj	],formation
R1439	T1829	T1828	punct	",",]
R1440	T1830	T1796	cc	and,requires
R1441	T1831	T1796	conj	regulates,requires
R1442	T1832	T1831	dobj	transcription,regulates
R1443	T1833	T1832	prep	of,transcription
R1444	T1834	T1836	det	a,range
R1445	T1835	T1836	amod	broad,range
R1446	T1836	T1833	pobj	range,of
R1447	T1837	T1836	prep	of,range
R1448	T1838	T1837	pobj	genes,of
R1449	T1839	T1838	acl	involved,genes
R1450	T1840	T1839	prep	in,involved
R1451	T1841	T1842	amod	immune,responses
R1452	T1842	T1840	pobj	responses,in
R1453	T1843	T1845	nmod	[,]
R1454	T1844	T1845	nummod	18-21,]
R1455	T1845	T1842	appos	],responses
R1456	T1846	T1796	punct	.,requires
R1457	T1847	T1848	preconj	Both,AP-1
R1458	T1848	T1852	amod	AP-1,sites
R1459	T1849	T1848	cc	and,AP-1
R1460	T1850	T1848	conj	NF-κB,AP-1
R1461	T1851	T1852	amod	binding,sites
R1462	T1852	T1855	nsubjpass	sites,identified
R1463	T1853	T1855	aux	have,identified
R1464	T1854	T1855	auxpass	been,identified
R1465	T1855	T1855	ROOT	identified,identified
R1466	T1856	T1855	prep	in,identified
R1467	T1857	T1859	det	the,region
R1468	T1858	T1859	compound	promoter,region
R1469	T1859	T1856	pobj	region,in
R1470	T1860	T1859	prep	of,region
R1471	T1861	T1860	pobj	IL-6,of
R1472	T1862	T1861	cc	and,IL-6
R1473	T1863	T1864	compound	CXCL8,[
R1474	T1864	T1866	compound	[,]
R1475	T1865	T1866	compound	"12,22",]
R1476	T1866	T1859	appos	],region
R1477	T1867	T1880	punct	",",is
R1478	T1868	T1880	advmod	however,is
R1479	T1869	T1880	punct	",",is
R1480	T1870	T1871	det	the,mechanism
R1481	T1871	T1880	nsubj	mechanism,is
R1482	T1872	T1877	prep	by,regulated
R1483	T1873	T1872	pobj	which,by
R1484	T1874	T1875	det	these,interleukins
R1485	T1875	T1877	nsubjpass	interleukins,regulated
R1486	T1876	T1877	auxpass	are,regulated
R1487	T1877	T1871	relcl	regulated,mechanism
R1488	T1878	T1877	prep	in,regulated
R1489	T1879	T1878	pobj	T-cells,in
R1490	T1880	T1855	conj	is,identified
R1491	T1881	T1880	advmod	still,is
R1492	T1882	T1880	neg	not,is
R1493	T1883	T1880	acomp	clear,is
R1494	T1884	T1880	punct	.,is
R1495	T1885	T1886	nsubj	CXCL8,is
R1496	T1886	T1886	ROOT	is,is
R1497	T1887	T1889	det	a,chemokine
R1498	T1888	T1889	amod	C-X-C,chemokine
R1499	T1889	T1886	attr	chemokine,is
R1500	T1890	T1889	prep	with,chemokine
R1501	T1891	T1890	pobj	properties,with
R1502	T1892	T1891	acl	enabling,properties
R1503	T1893	T1892	dobj	it,enabling
R1504	T1894	T1895	aux	to,recruit
R1505	T1895	T1892	xcomp	recruit,enabling
R1506	T1896	T1895	dobj	T-cells,recruit
R1507	T1897	T1896	cc	and,T-cells
R1508	T1898	T1896	conj	basophils,T-cells
R1509	T1899	T1895	cc	and,recruit
R1510	T1900	T1901	aux	to,activate
R1511	T1901	T1895	conj	activate,recruit
R1512	T1902	T1901	dobj	neutrophils,activate
R1513	T1903	T1902	cc	and,neutrophils
R1514	T1904	T1902	conj	monocytes,neutrophils
R1515	T1905	T1907	nmod	[,]
R1516	T1906	T1907	nummod	23,]
R1517	T1907	T1902	conj	],neutrophils
R1518	T1908	T1886	punct	.,is
R1519	T1909	T1910	nsubj	IL-6,is
R1520	T1910	T1910	ROOT	is,is
R1521	T1911	T1912	det	a,cytokine
R1522	T1912	T1910	attr	cytokine,is
R1523	T1913	T1914	nsubj	that,possesses
R1524	T1914	T1912	relcl	possesses,cytokine
R1525	T1915	T1916	preconj	both,pro-
R1526	T1916	T1919	amod	pro-,characteristics
R1527	T1917	T1916	cc	and,pro-
R1528	T1918	T1916	conj	anti-inflammatory,pro-
R1529	T1919	T1914	dobj	characteristics,possesses
R1530	T1920	T1910	cc	and,is
R1531	T1921	T1922	nsubj	that,plays
R1532	T1922	T1910	conj	plays,is
R1533	T1923	T1925	det	a,role
R1534	T1924	T1925	amod	key,role
R1535	T1925	T1922	dobj	role,plays
R1536	T1926	T1925	prep	in,role
R1537	T1927	T1926	pobj	haematopoiesis,in
R1538	T1928	T1927	cc	and,haematopoiesis
R1539	T1929	T1927	conj	acute-phase,haematopoiesis
R1540	T1930	T1933	compound	responses,]
R1541	T1931	T1933	compound	[,]
R1542	T1932	T1933	compound	"24,25",]
R1543	T1933	T1922	npadvmod	],plays
R1544	T1934	T1910	punct	.,is
R1545	T1935	T1937	det	The,study
R1546	T1936	T1937	amod	present,study
R1547	T1937	T1938	nsubj	study,suggests
R1548	T1938	T1938	ROOT	suggests,suggests
R1549	T1939	T1946	mark	that,is
R1550	T1940	T1941	det	the,regulation
R1551	T1941	T1946	nsubj	regulation,is
R1552	T1942	T1941	prep	of,regulation
R1553	T1943	T1942	pobj	CXCL8,of
R1554	T1944	T1943	cc	and,CXCL8
R1555	T1945	T1943	conj	IL-6,CXCL8
R1556	T1946	T1938	ccomp	is,suggests
R1557	T1947	T1946	acomp	uncoupled,is
R1558	T1948	T1938	punct	.,suggests
R1559	T1949	T1949	ROOT	Using,Using
R1560	T1950	T1951	compound	Jurkat,T-cells
R1561	T1951	T1949	dobj	T-cells,Using
R1562	T1952	T1951	acl	exposed,T-cells
R1563	T1953	T1952	prep	to,exposed
R1564	T1954	T1953	pobj	PMA,to
R1565	T1955	T1954	cc	and,PMA
R1566	T1956	T1954	conj	heat,PMA
R1567	T1957	T1951	acl	killed,T-cells
R1568	T1958	T1951	punct	(,T-cells
R1569	T1959	T1951	appos	HK,T-cells
R1570	T1960	T1951	punct	),T-cells
R1571	T1961	T1963	compound	Escherichia,MG1655
R1572	T1962	T1963	compound	coli,MG1655
R1573	T1963	T1976	advcl	MG1655,demonstrated
R1574	T1964	T1963	prep	in,MG1655
R1575	T1965	T1964	pobj	combination,in
R1576	T1966	T1963	prep	with,MG1655
R1577	T1967	T1966	pobj	inhibitors,with
R1578	T1968	T1967	prep	of,inhibitors
R1579	T1969	T1968	pobj	NF-κB,of
R1580	T1970	T1969	punct	",",NF-κB
R1581	T1971	T1969	conj	JNK,NF-κB
R1582	T1972	T1971	cc	and,JNK
R1583	T1973	T1971	conj	PKC,JNK
R1584	T1974	T1976	punct	",",demonstrated
R1585	T1975	T1976	nsubj	we,demonstrated
R1586	T1976	T1976	ROOT	demonstrated,demonstrated
R1587	T1977	T1979	mark	that,regulates
R1588	T1978	T1979	nsubj	NF-κB,regulates
R1589	T1979	T1976	ccomp	regulates,demonstrated
R1590	T1980	T1981	compound	IL-6,expression
R1591	T1981	T1979	dobj	expression,regulates
R1592	T1982	T1989	mark	while,correlated
R1593	T1983	T1984	det	the,regulation
R1594	T1984	T1989	nsubj	regulation,correlated
R1595	T1985	T1984	prep	of,regulation
R1596	T1986	T1985	pobj	CXCL8,of
R1597	T1987	T1986	amod	more,CXCL8
R1598	T1988	T1989	advmod	closely,correlated
R1599	T1989	T1979	advcl	correlated,regulates
R1600	T1990	T1989	prep	to,correlated
R1601	T1991	T1992	amod	AP-1,activity
R1602	T1992	T1990	pobj	activity,to
R1603	T1993	T1976	punct	.,demonstrated
R1604	T1994	T1995	det	These,results
R1605	T1995	T1996	nsubj	results,indicate
R1606	T1996	T1996	ROOT	indicate,indicate
R1607	T1997	T2001	mark	that,is
R1608	T1998	T2001	nsubj	inhibition,is
R1609	T1999	T1998	prep	of,inhibition
R1610	T2000	T1999	pobj	NF-κB,of
R1611	T2001	T1996	ccomp	is,indicate
R1612	T2002	T2001	neg	not,is
R1613	T2003	T2005	det	an,strategy
R1614	T2004	T2005	amod	effective,strategy
R1615	T2005	T2001	attr	strategy,is
R1616	T2006	T2005	prep	in,strategy
R1617	T2007	T2006	pcomp	countering,in
R1618	T2008	T2011	det	the,activities
R1619	T2009	T2011	amod	high,activities
R1620	T2010	T2011	nummod	CXCL8,activities
R1621	T2011	T2007	dobj	activities,countering
R1622	T2012	T2011	prep	in,activities
R1623	T2013	T2012	pobj	diseases,in
R1624	T2014	T2015	amod	such,as
R1625	T2015	T2013	prep	as,diseases
R1626	T2016	T2017	amod	cystic,fibrosis
R1627	T2017	T2015	pobj	fibrosis,as
R1628	T2018	T2017	punct	",",fibrosis
R1629	T2019	T2017	conj	AIDS,fibrosis
R1630	T2020	T2019	cc	and,AIDS
R1631	T2021	T2022	amod	pulmonary,fibrosis
R1632	T2022	T2019	conj	fibrosis,AIDS
R1633	T2023	T1996	punct	.,indicate

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T1441	898-903	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T2577	84-94	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2578	1333-1343	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2579	2372-2382	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2580	2613-2623	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2581	84-120	http://purl.obolibrary.org/obo/GO_0002676	denotes	regulation of inflammatory responses
T2582	84-120	http://purl.obolibrary.org/obo/GO_0050729	denotes	regulation of inflammatory responses
T2583	84-120	http://purl.obolibrary.org/obo/GO_0050727	denotes	regulation of inflammatory responses
T2584	84-120	http://purl.obolibrary.org/obo/GO_0050728	denotes	regulation of inflammatory responses
T2585	84-120	http://purl.obolibrary.org/obo/GO_0002673	denotes	regulation of inflammatory responses
T2586	98-120	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T2587	319-341	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T2588	837-849	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2589	250-268	http://purl.obolibrary.org/obo/GO_0008283	denotes	cell proliferation
T2590	791-809	http://purl.obolibrary.org/obo/GO_0032635	denotes	production of IL-6
T2591	791-809	http://purl.obolibrary.org/obo/GO_0032675	denotes	production of IL-6
T2592	1114-1124	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T2593	1214-1224	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T2594	1114-1133	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling pathways
T2595	1214-1233	http://purl.obolibrary.org/obo/GO_0007165	denotes	signalling pathways
T2596	1369-1387	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB is activated
T2597	1378-1409	http://purl.obolibrary.org/obo/GO_1901002	denotes	activated in response to stress
T2598	1391-1428	http://purl.obolibrary.org/obo/GO_1902884	denotes	response to stress, such as oxidative
T2599	1378-1409	http://purl.obolibrary.org/obo/GO_0032056	denotes	activated in response to stress
T2600	1391-1409	http://purl.obolibrary.org/obo/GO_0006950	denotes	response to stress
T2601	1391-1428	http://purl.obolibrary.org/obo/GO_1902883	denotes	response to stress, such as oxidative
T2602	1391-1428	http://purl.obolibrary.org/obo/GO_0006979	denotes	response to stress, such as oxidative
T2603	1391-1428	http://purl.obolibrary.org/obo/GO_0097468	denotes	response to stress, such as oxidative
T2604	1391-1428	http://purl.obolibrary.org/obo/GO_0034599	denotes	response to stress, such as oxidative
T2605	1700-1709	http://purl.obolibrary.org/obo/GO_0009058	denotes	formation
T2606	1760-1773	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T2607	1812-1828	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune responses
T2608	2117-2142	http://purl.obolibrary.org/obo/GO_0045575	denotes	basophils and to activate
T2609	2134-2154	http://purl.obolibrary.org/obo/GO_0042119	denotes	activate neutrophils
T2610	2516-2535	http://purl.obolibrary.org/obo/GO_0032088	denotes	inhibitors of NF-κB
T2611	2516-2535	http://purl.obolibrary.org/obo/GO_0007252	denotes	inhibitors of NF-κB
T2612	2537-2540	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T2613	2545-2548	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T2618	193-197	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2
T2619	199-203	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2620	422-426	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2621	805-809	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2622	1204-1208	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2623	1919-1923	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2624	2175-2179	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2625	2396-2400	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2626	2587-2591	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2627	1198-1206	http://purl.obolibrary.org/obo/GO_0005149	denotes	1 and IL
T2628	1852-1865	http://purl.obolibrary.org/obo/GO_0051059	denotes	NF-κB binding
T2629	1858-1865	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T2630	2170-2177	http://purl.obolibrary.org/obo/GO_0045519	denotes	23]. IL
T2631	2537-2540	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T2632	2545-2548	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T2633	60-64	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2634	250-254	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2635	1555-1559	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2636	2013-2018	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2637	2107-2112	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2638	2430-2435	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T1505	11-125	Sentence	denotes	Cytokines and chemokines are important in immune cell recruitment and in regulation of inflammatory responses [1].
T1506	126-346	Sentence	denotes	T-cells produce a broad range of inflammatory mediators, including IL-2, IL-6, TNF and CXCL8, all of which are important in cell proliferation, differentiation, communication and initiation of inflammatory responses [2].
T1507	347-554	Sentence	denotes	Elevated levels of pro-inflammatory cytokines and chemokines, such as TNF, IL-6 and CXCL8, are associated with several human diseases including cystic fibrosis [3-5], pulmonary fibrosis [6,7] and AIDS [8,9].
T1508	555-779	Sentence	denotes	Induction of CXCL8 has been suggested to be mediated through NF-κB in cooperation with AP-1 [10,11], however the precise mechanism is not fully elucidated, and treatment strategies aimed at inhibiting CXCL8 have failed [12].
T1509	780-930	Sentence	denotes	Persistent production of IL-6 and CXCL8 leads to chronic inflammation and enhanced survival of lymphocytes increasing serum cytokine/chemokine levels.
T1510	931-1029	Sentence	denotes	This forms the basis of several autoimmune disorders including plasmacytosis and hyperplasia [13].
T1511	1030-1209	Sentence	denotes	To develop viable CXCL8 based treatment strategies, it is necessary to identify the signalling pathways regulating CXCL8 and determine how this is coupled to NF-κB, AP-1 and IL-6.
T1512	1210-1368	Sentence	denotes	The signalling pathways leading to NF-κB and AP-1 activation are overlapping, where both are involved in the induction and regulation of cytokines/chemokines.
T1513	1369-1595	Sentence	denotes	NF-κB is activated in response to stress, such as oxidative stress, bacterial toxins, viruses and UV light [14], and is essential for differentiation, proliferation and survival of many cell types including T-lymphocytes [15].
T1514	1596-1837	Sentence	denotes	AP-1 activation requires Fos (c-Fos, FosB, Fra-1, Fra-2) and Jun (c-Jun, v-Jun, JunB, JunD) through the formation of homo- and hetero-dimers [16,17], and regulates transcription of a broad range of genes involved in immune responses [18-21].
T1515	1838-2038	Sentence	denotes	Both AP-1 and NF-κB binding sites have been identified in the promoter region of IL-6 and CXCL8 [12,22], however, the mechanism by which these interleukins are regulated in T-cells is still not clear.
T1516	2039-2174	Sentence	denotes	CXCL8 is a C-X-C chemokine with properties enabling it to recruit T-cells and basophils and to activate neutrophils and monocytes [23].
T1517	2175-2335	Sentence	denotes	IL-6 is a cytokine that possesses both pro- and anti-inflammatory characteristics and that plays a key role in haematopoiesis and acute-phase responses [24,25].
T1518	2336-2414	Sentence	denotes	The present study suggests that the regulation of CXCL8 and IL-6 is uncoupled.
T1519	2415-2674	Sentence	denotes	Using Jurkat T-cells exposed to PMA and heat killed (HK) Escherichia coli MG1655 in combination with inhibitors of NF-κB, JNK and PKC, we demonstrated that NF-κB regulates IL-6 expression while the regulation of CXCL8 more closely correlated to AP-1 activity.
T1520	2675-2857	Sentence	denotes	These results indicate that inhibition of NF-κB is not an effective strategy in countering the high CXCL8 activities in diseases such as cystic fibrosis, AIDS and pulmonary fibrosis.
T20	0-10	Sentence	denotes	Background
T21	11-125	Sentence	denotes	Cytokines and chemokines are important in immune cell recruitment and in regulation of inflammatory responses [1].
T22	126-346	Sentence	denotes	T-cells produce a broad range of inflammatory mediators, including IL-2, IL-6, TNF and CXCL8, all of which are important in cell proliferation, differentiation, communication and initiation of inflammatory responses [2].
T23	347-554	Sentence	denotes	Elevated levels of pro-inflammatory cytokines and chemokines, such as TNF, IL-6 and CXCL8, are associated with several human diseases including cystic fibrosis [3-5], pulmonary fibrosis [6,7] and AIDS [8,9].
T24	555-779	Sentence	denotes	Induction of CXCL8 has been suggested to be mediated through NF-κB in cooperation with AP-1 [10,11], however the precise mechanism is not fully elucidated, and treatment strategies aimed at inhibiting CXCL8 have failed [12].
T25	780-930	Sentence	denotes	Persistent production of IL-6 and CXCL8 leads to chronic inflammation and enhanced survival of lymphocytes increasing serum cytokine/chemokine levels.
T26	931-1029	Sentence	denotes	This forms the basis of several autoimmune disorders including plasmacytosis and hyperplasia [13].
T27	1030-1209	Sentence	denotes	To develop viable CXCL8 based treatment strategies, it is necessary to identify the signalling pathways regulating CXCL8 and determine how this is coupled to NF-κB, AP-1 and IL-6.
T28	1210-1368	Sentence	denotes	The signalling pathways leading to NF-κB and AP-1 activation are overlapping, where both are involved in the induction and regulation of cytokines/chemokines.
T29	1369-1595	Sentence	denotes	NF-κB is activated in response to stress, such as oxidative stress, bacterial toxins, viruses and UV light [14], and is essential for differentiation, proliferation and survival of many cell types including T-lymphocytes [15].
T30	1596-1837	Sentence	denotes	AP-1 activation requires Fos (c-Fos, FosB, Fra-1, Fra-2) and Jun (c-Jun, v-Jun, JunB, JunD) through the formation of homo- and hetero-dimers [16,17], and regulates transcription of a broad range of genes involved in immune responses [18-21].
T31	1838-2038	Sentence	denotes	Both AP-1 and NF-κB binding sites have been identified in the promoter region of IL-6 and CXCL8 [12,22], however, the mechanism by which these interleukins are regulated in T-cells is still not clear.
T32	2039-2174	Sentence	denotes	CXCL8 is a C-X-C chemokine with properties enabling it to recruit T-cells and basophils and to activate neutrophils and monocytes [23].
T33	2175-2335	Sentence	denotes	IL-6 is a cytokine that possesses both pro- and anti-inflammatory characteristics and that plays a key role in haematopoiesis and acute-phase responses [24,25].
T34	2336-2414	Sentence	denotes	The present study suggests that the regulation of CXCL8 and IL-6 is uncoupled.
T35	2415-2674	Sentence	denotes	Using Jurkat T-cells exposed to PMA and heat killed (HK) Escherichia coli MG1655 in combination with inhibitors of NF-κB, JNK and PKC, we demonstrated that NF-κB regulates IL-6 expression while the regulation of CXCL8 more closely correlated to AP-1 activity.
T36	2675-2857	Sentence	denotes	These results indicate that inhibition of NF-κB is not an effective strategy in countering the high CXCL8 activities in diseases such as cystic fibrosis, AIDS and pulmonary fibrosis.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T2614	491-506	http://purl.bioontology.org/ontology/ICD10/E84	denotes	cystic fibrosis
T2615	2812-2827	http://purl.bioontology.org/ontology/ICD10/E84	denotes	cystic fibrosis
T2616	491-506	http://purl.bioontology.org/ontology/ICD10/E84.9	denotes	cystic fibrosis
T2617	2812-2827	http://purl.bioontology.org/ontology/ICD10/E84.9	denotes	cystic fibrosis

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T2911	134-141	Gene_expression	denotes	produce
T2912	134-141	Gene_expression	denotes	produce
T2913	134-141	Gene_expression	denotes	produce
T2914	193-197	Protein	denotes	IL-2
T2915	199-203	Protein	denotes	IL-6
T2916	213-218	Protein	denotes	CXCL8
T2917	422-426	Protein	denotes	IL-6
T2918	431-436	Protein	denotes	CXCL8
T2919	555-564	Positive_regulation	denotes	Induction
T2920	568-573	Protein	denotes	CXCL8
T2921	599-607	Positive_regulation	denotes	mediated		true
T2922	745-755	Negative_regulation	denotes	inhibiting
T2923	756-761	Protein	denotes	CXCL8
T2924	791-801	Gene_expression	denotes	production
T2925	791-801	Gene_expression	denotes	production
T2926	805-809	Protein	denotes	IL-6
T2927	814-819	Protein	denotes	CXCL8
T2928	1048-1053	Protein	denotes	CXCL8
T2929	1134-1144	Regulation	denotes	regulating
T2930	1145-1150	Protein	denotes	CXCL8
T2931	1204-1208	Protein	denotes	IL-6
T2932	1626-1631	Protein	denotes	c-Fos
T2933	1633-1637	Protein	denotes	FosB
T2934	1639-1644	Protein	denotes	Fra-1
T2935	1646-1651	Protein	denotes	Fra-2
T2936	1662-1667	Protein	denotes	c-Jun
T2937	1669-1674	Protein	denotes	v-Jun
T2938	1676-1680	Protein	denotes	JunB
T2939	1682-1686	Protein	denotes	JunD
T2940	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2941	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2942	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2943	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2944	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2945	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2946	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2947	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2948	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2949	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2950	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2951	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2952	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2953	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2954	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2955	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T2956	1919-1923	Protein	denotes	IL-6
T2957	1928-1933	Protein	denotes	CXCL8
T2958	1998-2007	Regulation	denotes	regulated
T2959	1998-2007	Regulation	denotes	regulated
T2960	2039-2044	Protein	denotes	CXCL8
T2961	2175-2179	Protein	denotes	IL-6
T2962	2372-2382	Regulation	denotes	regulation
T2963	2372-2382	Regulation	denotes	regulation
T2964	2386-2391	Protein	denotes	CXCL8
T2965	2396-2400	Protein	denotes	IL-6
T2966	2577-2586	Regulation	denotes	regulates
T2967	2587-2591	Protein	denotes	IL-6
T2968	2592-2602	Gene_expression	denotes	expression
T2969	2613-2623	Regulation	denotes	regulation
T2970	2627-2632	Protein	denotes	CXCL8
T2971	2660-2664	Protein	denotes	AP-1
T2972	2755-2765	Negative_regulation	denotes	countering	true
T2973	2775-2780	Protein	denotes	CXCL8
R2323	T2914	T2913	themeOf	IL-2,produce
R2324	T2915	T2911	themeOf	IL-6,produce
R2325	T2916	T2912	themeOf	CXCL8,produce
R2326	T2919	T2921	themeOf	Induction,mediated
R2329	T2920	T2919	themeOf	CXCL8,Induction
R2330	T2923	T2922	themeOf	CXCL8,inhibiting
R2333	T2926	T2924	themeOf	IL-6,production
R2337	T2927	T2925	themeOf	CXCL8,production
R2342	T2930	T2929	themeOf	CXCL8,regulating
R2344	T2932	T2955	themeOf	c-Fos,formation of homo- and hetero-dimers
R2345	T2932	T2951	themeOf	c-Fos,formation of homo- and hetero-dimers
R2346	T2932	T2952	themeOf	c-Fos,formation of homo- and hetero-dimers
R2347	T2932	T2953	themeOf	c-Fos,formation of homo- and hetero-dimers
R2348	T2933	T2954	themeOf	FosB,formation of homo- and hetero-dimers
R2349	T2933	T2946	themeOf	FosB,formation of homo- and hetero-dimers
R2350	T2933	T2940	themeOf	FosB,formation of homo- and hetero-dimers
R2351	T2933	T2944	themeOf	FosB,formation of homo- and hetero-dimers
R2352	T2934	T2943	themeOf	Fra-1,formation of homo- and hetero-dimers
R2353	T2934	T2942	themeOf	Fra-1,formation of homo- and hetero-dimers
R2354	T2934	T2941	themeOf	Fra-1,formation of homo- and hetero-dimers
R2355	T2934	T2945	themeOf	Fra-1,formation of homo- and hetero-dimers
R2356	T2935	T2947	themeOf	Fra-2,formation of homo- and hetero-dimers
R2357	T2935	T2948	themeOf	Fra-2,formation of homo- and hetero-dimers
R2358	T2935	T2949	themeOf	Fra-2,formation of homo- and hetero-dimers
R2359	T2935	T2950	themeOf	Fra-2,formation of homo- and hetero-dimers
R2360	T2936	T2955	themeOf	c-Jun,formation of homo- and hetero-dimers
R2361	T2936	T2954	themeOf	c-Jun,formation of homo- and hetero-dimers
R2362	T2936	T2943	themeOf	c-Jun,formation of homo- and hetero-dimers
R2363	T2936	T2947	themeOf	c-Jun,formation of homo- and hetero-dimers
R2364	T2937	T2951	themeOf	v-Jun,formation of homo- and hetero-dimers
R2365	T2937	T2946	themeOf	v-Jun,formation of homo- and hetero-dimers
R2366	T2937	T2942	themeOf	v-Jun,formation of homo- and hetero-dimers
R2367	T2937	T2948	themeOf	v-Jun,formation of homo- and hetero-dimers
R2368	T2938	T2952	themeOf	JunB,formation of homo- and hetero-dimers
R2369	T2938	T2940	themeOf	JunB,formation of homo- and hetero-dimers
R2370	T2938	T2941	themeOf	JunB,formation of homo- and hetero-dimers
R2371	T2938	T2949	themeOf	JunB,formation of homo- and hetero-dimers
R2372	T2939	T2953	themeOf	JunD,formation of homo- and hetero-dimers
R2373	T2939	T2944	themeOf	JunD,formation of homo- and hetero-dimers
R2374	T2939	T2945	themeOf	JunD,formation of homo- and hetero-dimers
R2375	T2939	T2950	themeOf	JunD,formation of homo- and hetero-dimers
R2381	T2956	T2958	themeOf	IL-6,regulated
R2382	T2957	T2959	themeOf	CXCL8,regulated
R2385	T2964	T2962	themeOf	CXCL8,regulation
R2386	T2965	T2963	themeOf	IL-6,regulation
R2387	T2967	T2968	themeOf	IL-6,expression
R2388	T2968	T2966	themeOf	expression,regulates
R2390	T2970	T2969	themeOf	CXCL8,regulation
R2391	T2973	T2972	themeOf	CXCL8,countering

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T2974	193-197	Protein	denotes	IL-2
T2975	199-203	Protein	denotes	IL-6
T2976	205-208	Protein	denotes	TNF
T2977	213-218	Protein	denotes	CXCL8
T2978	134-141	Gene_expression	denotes	produce
T2979	134-141	Gene_expression	denotes	produce
T2980	134-141	Gene_expression	denotes	produce
T2981	134-141	Gene_expression	denotes	produce
T2982	417-420	Protein	denotes	TNF
T2983	422-426	Protein	denotes	IL-6
T2984	431-436	Protein	denotes	CXCL8
T2985	568-573	Protein	denotes	CXCL8
T2986	616-621	Protein	denotes	NF-κB
T2987	756-761	Protein	denotes	CXCL8
T2988	555-564	Positive_regulation	denotes	Induction
T2989	599-607	Positive_regulation	denotes	mediated
T2990	745-755	Negative_regulation	denotes	inhibiting
T2991	805-809	Protein	denotes	IL-6
T2992	814-819	Protein	denotes	CXCL8
T2993	791-801	Gene_expression	denotes	production
T2994	791-801	Gene_expression	denotes	production
T2995	1048-1053	Protein	denotes	CXCL8
T2996	1145-1150	Protein	denotes	CXCL8
T2997	1188-1193	Protein	denotes	NF-κB
T2998	1195-1199	Protein	denotes	AP-1
T2999	1204-1208	Protein	denotes	IL-6
T3000	1134-1144	Regulation	denotes	regulating
T3001	1245-1250	Protein	denotes	NF-κB
T3002	1255-1259	Protein	denotes	AP-1
T3003	1260-1270	Positive_regulation	denotes	activation
T3004	1260-1270	Positive_regulation	denotes	activation
T3005	1369-1374	Protein	denotes	NF-κB
T3006	1437-1453	Protein	denotes	bacterial toxins
T3007	1378-1387	Positive_regulation	denotes	activated
T3008	1596-1600	Protein	denotes	AP-1
T3009	1621-1624	Protein	denotes	Fos
T3010	1626-1631	Protein	denotes	c-Fos
T3011	1633-1637	Protein	denotes	FosB
T3012	1639-1644	Protein	denotes	Fra-1
T3013	1646-1651	Protein	denotes	Fra-2
T3014	1657-1660	Protein	denotes	Jun
T3015	1662-1667	Protein	denotes	c-Jun
T3016	1669-1674	Protein	denotes	v-Jun
T3017	1676-1680	Protein	denotes	JunB
T3018	1682-1686	Protein	denotes	JunD
T3019	1601-1611	Positive_regulation	denotes	activation
T3020	1612-1620	Positive_regulation	denotes	requires
T3021	1612-1620	Positive_regulation	denotes	requires
T3022	1843-1847	Protein	denotes	AP-1
T3023	1852-1857	Protein	denotes	NF-κB
T3024	1919-1923	Protein	denotes	IL-6
T3025	1928-1933	Protein	denotes	CXCL8
T3026	1981-1993	Protein	denotes	interleukins
T3027	1998-2007	Regulation	denotes	regulated
T3028	2039-2044	Protein	denotes	CXCL8
T3029	2175-2179	Protein	denotes	IL-6
T3030	2386-2391	Protein	denotes	CXCL8
T3031	2396-2400	Protein	denotes	IL-6
T3032	2372-2382	Regulation	denotes	regulation
T3033	2372-2382	Regulation	denotes	regulation
T3034	2530-2535	Protein	denotes	NF-κB
T3035	2537-2540	Protein	denotes	JNK
T3036	2545-2548	Protein	denotes	PKC
T3037	2571-2576	Protein	denotes	NF-κB
T3038	2587-2591	Protein	denotes	IL-6
T3039	2627-2632	Protein	denotes	CXCL8
T3040	2660-2664	Protein	denotes	AP-1
T3041	2516-2526	Negative_regulation	denotes	inhibitors
T3042	2516-2526	Negative_regulation	denotes	inhibitors
T3043	2516-2526	Negative_regulation	denotes	inhibitors
T3044	2592-2602	Gene_expression	denotes	expression
T3045	2613-2623	Regulation	denotes	regulation
T3046	2577-2586	Regulation	denotes	regulates
T3047	2717-2722	Protein	denotes	NF-κB
T3048	2775-2780	Protein	denotes	CXCL8
T3049	2703-2713	Negative_regulation	denotes	inhibition
R2339	T2974	T2978	themeOf	IL-2,produce
R2340	T2975	T2979	themeOf	IL-6,produce
R2341	T2976	T2980	themeOf	TNF,produce
R2343	T2977	T2981	themeOf	CXCL8,produce
R2376	T2985	T2988	themeOf	CXCL8,Induction
R2377	T2986	T2989	causeOf	NF-κB,mediated
R2378	T2987	T2990	themeOf	CXCL8,inhibiting
R2379	T2988	T2989	themeOf	Induction,mediated
R2380	T2991	T2993	themeOf	IL-6,production
R2383	T2992	T2994	themeOf	CXCL8,production
R2384	T2996	T3000	themeOf	CXCL8,regulating
R2389	T3001	T3003	themeOf	NF-κB,activation
R2392	T3002	T3004	themeOf	AP-1,activation
R2393	T3005	T3007	themeOf	NF-κB,activated
R2394	T3008	T3019	themeOf	AP-1,activation
R2395	T3010	T3020	themeOf	c-Fos,requires
R2396	T3044	T3046	themeOf	expression,regulates
R2397	T3015	T3021	themeOf	c-Jun,requires
R2398	T3047	T3049	themeOf	NF-κB,inhibition
R2399	T3026	T3027	themeOf	interleukins,regulated
R2400	T3030	T3032	themeOf	CXCL8,regulation
R2401	T3031	T3033	themeOf	IL-6,regulation
R2402	T3034	T3041	themeOf	NF-κB,inhibitors
R2403	T3035	T3042	themeOf	JNK,inhibitors
R2404	T3036	T3043	themeOf	PKC,inhibitors
R2405	T3037	T3046	causeOf	NF-κB,regulates
R2406	T3038	T3044	themeOf	IL-6,expression
R2407	T3039	T3045	themeOf	CXCL8,regulation

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T1442	134-141	Gene_expression	denotes	produce
T1443	134-141	Gene_expression	denotes	produce
T1444	134-141	Gene_expression	denotes	produce
T1445	193-197	Protein	denotes	IL-2
T1446	199-203	Protein	denotes	IL-6
T1447	213-218	Protein	denotes	CXCL8
T1448	422-426	Protein	denotes	IL-6
T1449	431-436	Protein	denotes	CXCL8
T1450	555-564	Positive_regulation	denotes	Induction
T1451	568-573	Protein	denotes	CXCL8
T1452	599-607	Positive_regulation	denotes	mediated		true
T1453	745-755	Negative_regulation	denotes	inhibiting
T1454	756-761	Protein	denotes	CXCL8
T1455	791-801	Gene_expression	denotes	production
T1456	791-801	Gene_expression	denotes	production
T1457	805-809	Protein	denotes	IL-6
T1458	814-819	Protein	denotes	CXCL8
T1459	1048-1053	Protein	denotes	CXCL8
T1460	1134-1144	Regulation	denotes	regulating
T1461	1145-1150	Protein	denotes	CXCL8
T1462	1204-1208	Protein	denotes	IL-6
T1463	1626-1631	Protein	denotes	c-Fos
T1464	1633-1637	Protein	denotes	FosB
T1465	1639-1644	Protein	denotes	Fra-1
T1466	1646-1651	Protein	denotes	Fra-2
T1467	1662-1667	Protein	denotes	c-Jun
T1468	1669-1674	Protein	denotes	v-Jun
T1469	1676-1680	Protein	denotes	JunB
T1470	1682-1686	Protein	denotes	JunD
T1471	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1472	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1473	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1474	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1475	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1476	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1477	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1478	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1479	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1480	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1481	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1482	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1483	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1484	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1485	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1486	1700-1736	Binding	denotes	formation of homo- and hetero-dimers
T1487	1919-1923	Protein	denotes	IL-6
T1488	1928-1933	Protein	denotes	CXCL8
T1489	1998-2007	Regulation	denotes	regulated
T1490	1998-2007	Regulation	denotes	regulated
T1491	2039-2044	Protein	denotes	CXCL8
T1492	2175-2179	Protein	denotes	IL-6
T1493	2372-2382	Regulation	denotes	regulation
T1494	2372-2382	Regulation	denotes	regulation
T1495	2386-2391	Protein	denotes	CXCL8
T1496	2396-2400	Protein	denotes	IL-6
T1497	2577-2586	Regulation	denotes	regulates
T1498	2587-2591	Protein	denotes	IL-6
T1499	2592-2602	Gene_expression	denotes	expression
T1500	2613-2623	Regulation	denotes	regulation
T1501	2627-2632	Protein	denotes	CXCL8
T1502	2660-2664	Protein	denotes	AP-1
T1503	2755-2765	Negative_regulation	denotes	countering	true
T1504	2775-2780	Protein	denotes	CXCL8
R1086	T1451	T1450	themeOf	CXCL8,Induction
R1087	T1454	T1453	themeOf	CXCL8,inhibiting
R1088	T1457	T1455	themeOf	IL-6,production
R1089	T1458	T1456	themeOf	CXCL8,production
R1090	T1461	T1460	themeOf	CXCL8,regulating
R1091	T1463	T1486	themeOf	c-Fos,formation of homo- and hetero-dimers
R1092	T1463	T1482	themeOf	c-Fos,formation of homo- and hetero-dimers
R1093	T1463	T1483	themeOf	c-Fos,formation of homo- and hetero-dimers
R1094	T1463	T1484	themeOf	c-Fos,formation of homo- and hetero-dimers
R1095	T1464	T1485	themeOf	FosB,formation of homo- and hetero-dimers
R1096	T1464	T1477	themeOf	FosB,formation of homo- and hetero-dimers
R1097	T1464	T1471	themeOf	FosB,formation of homo- and hetero-dimers
R1098	T1464	T1475	themeOf	FosB,formation of homo- and hetero-dimers
R1099	T1465	T1474	themeOf	Fra-1,formation of homo- and hetero-dimers
R1100	T1465	T1473	themeOf	Fra-1,formation of homo- and hetero-dimers
R1101	T1465	T1472	themeOf	Fra-1,formation of homo- and hetero-dimers
R1102	T1465	T1476	themeOf	Fra-1,formation of homo- and hetero-dimers
R1103	T1466	T1478	themeOf	Fra-2,formation of homo- and hetero-dimers
R1104	T1466	T1479	themeOf	Fra-2,formation of homo- and hetero-dimers
R1105	T1466	T1480	themeOf	Fra-2,formation of homo- and hetero-dimers
R1106	T1466	T1481	themeOf	Fra-2,formation of homo- and hetero-dimers
R1107	T1467	T1486	themeOf	c-Jun,formation of homo- and hetero-dimers
R1108	T1467	T1485	themeOf	c-Jun,formation of homo- and hetero-dimers
R1109	T1467	T1474	themeOf	c-Jun,formation of homo- and hetero-dimers
R1110	T1467	T1478	themeOf	c-Jun,formation of homo- and hetero-dimers
R1111	T1468	T1482	themeOf	v-Jun,formation of homo- and hetero-dimers
R1112	T1468	T1477	themeOf	v-Jun,formation of homo- and hetero-dimers
R1113	T1468	T1473	themeOf	v-Jun,formation of homo- and hetero-dimers
R1114	T1468	T1479	themeOf	v-Jun,formation of homo- and hetero-dimers
R1115	T1469	T1483	themeOf	JunB,formation of homo- and hetero-dimers
R1116	T1469	T1471	themeOf	JunB,formation of homo- and hetero-dimers
R1117	T1469	T1472	themeOf	JunB,formation of homo- and hetero-dimers
R1118	T1469	T1480	themeOf	JunB,formation of homo- and hetero-dimers
R1119	T1470	T1484	themeOf	JunD,formation of homo- and hetero-dimers
R1120	T1470	T1475	themeOf	JunD,formation of homo- and hetero-dimers
R1121	T1470	T1476	themeOf	JunD,formation of homo- and hetero-dimers
R1122	T1470	T1481	themeOf	JunD,formation of homo- and hetero-dimers
R1123	T1487	T1489	themeOf	IL-6,regulated
R1124	T1488	T1490	themeOf	CXCL8,regulated
R1125	T1495	T1493	themeOf	CXCL8,regulation
R1126	T1496	T1494	themeOf	IL-6,regulation
R1127	T1498	T1499	themeOf	IL-6,expression
R1128	T1499	T1497	themeOf	expression,regulates
R1129	T1501	T1500	themeOf	CXCL8,regulation
R1130	T1504	T1503	themeOf	CXCL8,countering
R1082	T1445	T1444	themeOf	IL-2,produce
R1083	T1446	T1442	themeOf	IL-6,produce
R1084	T1447	T1443	themeOf	CXCL8,produce
R1085	T1450	T1452	themeOf	Induction,mediated

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T2527	193-197	P60568	denotes	IL-2
T2528	199-203	P05231	denotes	IL-6
T2529	205-208	P01375	denotes	TNF
T2530	213-218	P10145	denotes	CXCL8
T2531	417-420	P01375	denotes	TNF
T2532	422-426	P05231	denotes	IL-6
T2533	431-436	P10145	denotes	CXCL8
T2534	568-573	P10145	denotes	CXCL8
T2535	642-646	P05412	denotes	AP-1
T2536	736-741	P26358	denotes	aimed
T2537	756-761	P10145	denotes	CXCL8
T2538	805-809	P05231	denotes	IL-6
T2539	814-819	P10145	denotes	CXCL8
T2540	1048-1053	P10145	denotes	CXCL8
T2541	1145-1150	P10145	denotes	CXCL8
T2542	1195-1199	P05412	denotes	AP-1
T2543	1204-1208	P05231	denotes	IL-6
T2544	1255-1259	P05412	denotes	AP-1
T2545	1596-1600	P05412	denotes	AP-1
T2546	1657-1660	P05412	denotes	Jun
T2547	1662-1667	P05412	denotes	c-Jun
T2548	1664-1667	P05412	denotes	Jun
T2549	1671-1674	P05412	denotes	Jun
T2550	1843-1847	P05412	denotes	AP-1
T2551	1919-1923	P05231	denotes	IL-6
T2552	1928-1933	P10145	denotes	CXCL8
T2553	2039-2044	P10145	denotes	CXCL8
T2554	2175-2179	P05231	denotes	IL-6
T2555	2386-2391	P10145	denotes	CXCL8
T2556	2396-2400	P05231	denotes	IL-6
T2557	2587-2591	P05231	denotes	IL-6
T2558	2627-2632	P10145	denotes	CXCL8
T2559	2660-2664	P05412	denotes	AP-1
T2560	2775-2780	P10145	denotes	CXCL8

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T1400	193-197	Protein	denotes	IL-2
T1401	199-203	Protein	denotes	IL-6
T1402	213-218	Protein	denotes	CXCL8
T1403	422-426	Protein	denotes	IL-6
T1404	431-436	Protein	denotes	CXCL8		true
T1405	555-564	Positive_regulation	denotes	Induction
T1406	568-573	Protein	denotes	CXCL8
T1407	599-607	Positive_regulation	denotes	mediated
T1408	745-755	Negative_regulation	denotes	inhibiting
T1409	756-761	Protein	denotes	CXCL8
T1410	791-801	Gene_expression	denotes	production
T1411	805-809	Protein	denotes	IL-6
T1412	814-819	Protein	denotes	CXCL8
T1413	1048-1053	Protein	denotes	CXCL8
T1414	1134-1144	Regulation	denotes	regulating
T1415	1145-1150	Protein	denotes	CXCL8
T1416	1177-1184	Positive_regulation	denotes	coupled
T1417	1204-1208	Protein	denotes	IL-6
T1418	1626-1631	Protein	denotes	c-Fos
T1419	1633-1637	Protein	denotes	FosB
T1420	1639-1644	Protein	denotes	Fra-1
T1421	1646-1651	Protein	denotes	Fra-2
T1422	1662-1667	Protein	denotes	c-Jun
T1423	1669-1674	Protein	denotes	v-Jun
T1424	1676-1680	Protein	denotes	JunB
T1425	1682-1686	Protein	denotes	JunD
T1426	1710-1736	Binding	denotes	of homo- and hetero-dimers
T1427	1919-1923	Protein	denotes	IL-6
T1428	1928-1933	Protein	denotes	CXCL8
T1429	2039-2044	Protein	denotes	CXCL8
T1430	2175-2179	Protein	denotes	IL-6
T1431	2372-2382	Regulation	denotes	regulation
T1432	2386-2391	Protein	denotes	CXCL8	true
T1433	2396-2400	Protein	denotes	IL-6
T1434	2577-2586	Regulation	denotes	regulates
T1435	2587-2591	Protein	denotes	IL-6
T1436	2592-2602	Gene_expression	denotes	expression
T1437	2613-2623	Regulation	denotes	regulation
T1438	2627-2632	Protein	denotes	CXCL8
T1439	2660-2664	Protein	denotes	AP-1
T1440	2775-2780	Protein	denotes	CXCL8
R1065	T1405	T1407	themeOf	Induction,mediated
R1066	T1406	T1405	themeOf	CXCL8,Induction
R1067	T1409	T1408	themeOf	CXCL8,inhibiting
R1068	T1411	T1410	themeOf	IL-6,production
R1069	T1412	T1410	themeOf	CXCL8,production
R1070	T1415	T1414	themeOf	CXCL8,regulating
R1071	T1419	T1426	themeOf	FosB,of homo- and hetero-dimers
R1072	T1420	T1426	themeOf	Fra-1,of homo- and hetero-dimers
R1073	T1421	T1426	themeOf	Fra-2,of homo- and hetero-dimers
R1074	T1423	T1426	themeOf	v-Jun,of homo- and hetero-dimers
R1075	T1424	T1426	themeOf	JunB,of homo- and hetero-dimers
R1076	T1425	T1426	themeOf	JunD,of homo- and hetero-dimers
R1077	T1432	T1431	themeOf	CXCL8,regulation
R1078	T1433	T1431	themeOf	IL-6,regulation
R1079	T1435	T1436	themeOf	IL-6,expression
R1080	T1436	T1434	themeOf	expression,regulates
R1081	T1438	T1437	themeOf	CXCL8,regulation

PMC:2889865 / 2473-5330 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:2889865 / 2473-5330 JSON TXT