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PMC:2889865 / 16307-25133 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T8442 11-16 NN denotes NF-κB
T8443 17-20 CC denotes and
T8444 21-25 NN denotes AP-1
T8445 26-29 VB denotes are
T8446 30-38 JJ denotes critical
T8447 39-49 NN denotes regulators
T8448 50-52 IN denotes of
T8449 53-65 JJ denotes inflammatory
T8450 66-75 NN denotes responses
T8451 75-76 -COMMA- denotes ,
T8452 77-90 NN denotes proliferation
T8453 91-94 CC denotes and
T8454 95-110 NN denotes differentiation
T8455 111-113 IN denotes of
T8456 114-121 NN denotes T-cells
T8457 122-123 -LRB- denotes [
T8458 123-128 CD denotes 28-30
T8459 128-129 -RRB- denotes ]
T8460 129-130 -COMMA- denotes ,
T8461 131-138 RB denotes however
T8462 138-139 -COMMA- denotes ,
T8463 140-143 DT denotes the
T8464 144-150 NN denotes signal
T8465 151-163 NN denotes transduction
T8466 164-167 CC denotes and
T8467 168-178 JJ denotes subsequent
T8468 179-197 NN denotes cytokine/chemokine
T8469 198-208 NN denotes expression
T8470 209-211 VB denotes is
T8471 212-215 RB denotes not
T8472 216-221 RB denotes fully
T8473 222-232 VB denotes understood
T8474 234-237 DT denotes The
T8475 238-241 NN denotes aim
T8476 242-244 IN denotes of
T8477 245-248 DT denotes the
T8478 249-256 JJ denotes present
T8479 257-262 NN denotes study
T8480 263-266 VB denotes was
T8481 267-269 TO denotes to
T8482 270-281 VB denotes investigate
T8483 282-286 NN denotes IL-6
T8484 287-290 CC denotes and
T8485 291-296 NN denotes CXCL8
T8486 297-307 NN denotes regulation
T8487 308-310 IN denotes by
T8488 311-316 NN denotes NF-κB
T8489 317-320 CC denotes and
T8490 321-325 NN denotes AP-1
T8491 326-328 IN denotes in
T8492 329-335 NN denotes Jurkat
T8493 336-343 NN denotes T-cells
T8494 345-348 PRP-DOLLAR- denotes Our
T8495 349-356 NN denotes results
T8496 357-369 VB denotes demonstrated
T8497 370-374 IN denotes that
T8498 375-378 NN denotes PMA
T8499 379-386 VB denotes induced
T8500 387-391 NN denotes AP-1
T8501 392-402 NN denotes activation
T8502 402-403 -COMMA- denotes ,
T8503 404-414 VB denotes indicating
T8504 415-416 DT denotes a
T8505 417-425 JJ denotes specific
T8506 426-436 NN denotes activation
T8507 437-439 IN denotes of
T8508 440-443 DT denotes the
T8509 444-448 NN denotes MAPK
T8510 449-456 NN denotes pathway
T8511 458-469 RB denotes Furthermore
T8512 469-470 -COMMA- denotes ,
T8513 471-473 PRP denotes we
T8514 474-486 VB denotes demonstrated
T8515 487-491 IN denotes that
T8516 492-495 NN denotes PMA
T8517 496-505 JJ denotes dependent
T8518 506-510 NN denotes AP-1
T8519 511-521 NN denotes activation
T8520 522-524 IN denotes in
T8521 525-532 NN denotes T-cells
T8522 533-536 VB denotes was
T8523 537-544 VB denotes delayed
T8524 545-546 -LRB- denotes (
T8525 546-547 SYM denotes >
T8526 547-548 CD denotes 2
T8527 549-550 NN denotes h
T8528 550-551 -RRB- denotes )
T8529 552-555 CC denotes and
T8530 556-565 VB denotes increased
T8531 566-575 VB denotes following
T8532 576-585 JJ denotes long-term
T8533 586-595 NN denotes treatment
T8534 597-601 NN denotes MAPK
T8535 602-604 VB denotes is
T8536 605-608 CD denotes one
T8537 609-611 IN denotes of
T8538 612-615 DT denotes the
T8539 616-620 JJ denotes main
T8540 621-631 NN denotes signalling
T8541 632-640 NN denotes pathways
T8542 641-643 IN denotes in
T8543 644-651 NN denotes T-cells
T8544 652-656 WDT denotes that
T8545 657-665 VB denotes regulate
T8546 666-671 NN denotes cell-
T8547 672-675 CC denotes and
T8548 676-691 JJ denotes transcriptional
T8549 692-702 NN denotes activation
T8550 703-704 -LRB- denotes [
T8551 704-709 CD denotes 31,32
T8552 709-710 -RRB- denotes ]
T8553 712-719 JJ denotes Several
T8554 720-727 NN denotes studies
T8555 728-729 -LRB- denotes [
T8556 729-737 CD denotes 20,33,34
T8557 737-738 -RRB- denotes ]
T8558 739-743 VB denotes have
T8559 744-753 VB denotes indicated
T8560 754-757 DT denotes the
T8561 758-768 NN denotes importance
T8562 769-771 IN denotes of
T8563 772-776 NN denotes AP-1
T8564 777-779 IN denotes in
T8565 780-786 NN denotes T-cell
T8566 787-797 NN denotes activation
T8567 798-801 CC denotes and
T8568 802-805 DT denotes the
T8569 806-815 NN denotes induction
T8570 816-818 IN denotes of
T8571 819-831 JJ denotes inflammatory
T8572 832-841 NN denotes responses
T8573 842-843 -LRB- denotes [
T8574 843-845 CD denotes 35
T8575 845-846 -RRB- denotes ]
T8576 846-847 -COMMA- denotes ,
T8577 848-857 VB denotes including
T8578 858-874 JJ denotes pro-inflammatory
T8579 875-883 NN denotes cytokine
T8580 884-891 NN denotes release
T8581 893-895 IN denotes In
T8582 896-904 NN denotes contrast
T8583 905-907 TO denotes to
T8584 908-912 NN denotes AP-1
T8585 912-913 -COMMA- denotes ,
T8586 914-919 NN denotes NF-κB
T8587 920-928 NN denotes activity
T8588 929-936 RB denotes rapidly
T8589 937-946 VB denotes increased
T8590 947-948 -LRB- denotes (
T8591 948-949 CD denotes 1
T8592 950-953 NN denotes min
T8593 953-954 -RRB- denotes )
T8594 955-961 IN denotes during
T8595 962-965 NN denotes PMA
T8596 966-974 NN denotes exposure
T8597 975-983 VB denotes followed
T8598 984-986 IN denotes by
T8599 987-988 DT denotes a
T8600 989-1004 NN denotes down-regulation
T8601 1005-1007 TO denotes to
T8602 1008-1011 DT denotes the
T8603 1012-1018 JJ denotes lowest
T8604 1019-1025 NN denotes levels
T8605 1026-1028 IN denotes at
T8606 1029-1030 CD denotes 6
T8607 1031-1032 NN denotes h
T8608 1034-1038 DT denotes This
T8609 1039-1041 VB denotes is
T8610 1042-1044 IN denotes in
T8611 1045-1049 NN denotes line
T8612 1050-1054 IN denotes with
T8613 1055-1059 NNP denotes Park
T8614 1060-1063 CC denotes and
T8615 1064-1074 NN denotes colleagues
T8616 1075-1076 -LRB- denotes [
T8617 1076-1078 CD denotes 36
T8618 1078-1079 -RRB- denotes ]
T8619 1080-1083 WP denotes who
T8620 1084-1096 VB denotes demonstrated
T8621 1097-1098 DT denotes a
T8622 1099-1104 JJ denotes rapid
T8623 1105-1113 NN denotes increase
T8624 1114-1116 IN denotes in
T8625 1117-1122 NN denotes NF-κB
T8626 1123-1131 NN denotes activity
T8627 1132-1141 VB denotes following
T8628 1142-1152 JJ denotes short-term
T8629 1153-1164 NN denotes stimulation
T8630 1165-1169 IN denotes with
T8631 1170-1173 NN denotes PMA
T8632 1173-1174 -COMMA- denotes ,
T8633 1175-1178 CC denotes but
T8634 1179-1188 VB denotes prolonged
T8635 1189-1198 NN denotes challenge
T8636 1199-1207 VB denotes resulted
T8637 1208-1210 IN denotes in
T8638 1211-1212 DT denotes a
T8639 1213-1223 JJ denotes persistent
T8640 1224-1234 NN denotes inhibition
T8641 1235-1237 IN denotes of
T8642 1238-1243 NN denotes NF-κB
T8643 1245-1249 PRP denotes They
T8644 1250-1256 VB denotes showed
T8645 1257-1261 IN denotes that
T8646 1262-1265 DT denotes the
T8647 1266-1276 NN denotes inhibition
T8648 1277-1279 IN denotes of
T8649 1280-1285 NN denotes NF-κB
T8650 1286-1289 VB denotes was
T8651 1290-1293 JJ denotes due
T8652 1294-1296 TO denotes to
T8653 1297-1310 JJ denotes PKC-dependent
T8654 1311-1322 NN denotes degradation
T8655 1323-1325 IN denotes of
T8656 1326-1329 NN denotes IκB
T8657 1330-1336 NN denotes kinase
T8658 1337-1338 NN denotes β
T8659 1339-1342 CC denotes and
T8660 1343-1344 VB denotes γ
T8661 1345-1347 IN denotes in
T8662 1348-1356 NN denotes response
T8663 1357-1359 TO denotes to
T8664 1360-1363 NN denotes PMA
T8665 1365-1378 RB denotes Interestingly
T8666 1378-1379 -COMMA- denotes ,
T8667 1380-1383 DT denotes the
T8668 1384-1386 NN denotes HK
T8669 1387-1389 FW denotes E.
T8670 1390-1394 FW denotes coli
T8671 1395-1403 NN denotes exposure
T8672 1404-1411 VB denotes induced
T8673 1412-1417 NN denotes NF-κB
T8674 1418-1428 NN denotes activation
T8675 1429-1436 IN denotes without
T8676 1437-1446 VB denotes affecting
T8677 1447-1451 NN denotes AP-1
T8678 1452-1460 NN denotes activity
T8679 1462-1466 NNP denotes Wang
T8680 1467-1470 CC denotes and
T8681 1471-1481 NN denotes colleagues
T8682 1482-1483 -LRB- denotes [
T8683 1483-1485 CD denotes 37
T8684 1485-1486 -RRB- denotes ]
T8685 1487-1495 VB denotes reported
T8686 1496-1498 DT denotes an
T8687 1499-1507 JJ denotes elevated
T8688 1508-1520 JJ denotes inflammatory
T8689 1521-1529 NN denotes response
T8690 1530-1532 IN denotes by
T8691 1533-1542 VB denotes obtaining
T8692 1543-1553 NN denotes expression
T8693 1554-1556 IN denotes of
T8694 1557-1561 NN denotes IL-6
T8695 1562-1571 VB denotes following
T8696 1572-1575 DT denotes the
T8697 1576-1584 NN denotes exposure
T8698 1585-1587 IN denotes of
T8699 1588-1595 NN denotes T-cells
T8700 1596-1598 TO denotes to
T8701 1599-1612 NN denotes peptidoglycan
T8702 1614-1623 NN denotes Reduction
T8703 1624-1626 IN denotes in
T8704 1627-1632 NN denotes NF-κB
T8705 1633-1635 IN denotes by
T8706 1636-1643 NN denotes calcium
T8707 1644-1653 NN denotes ionophore
T8708 1654-1663 VB denotes following
T8709 1664-1666 NN denotes HK
T8710 1667-1669 FW denotes E.
T8711 1670-1674 FW denotes coli
T8712 1675-1686 NN denotes stimulation
T8713 1687-1690 MD denotes may
T8714 1691-1693 VB denotes be
T8715 1694-1697 JJ denotes due
T8716 1698-1700 TO denotes to
T8717 1701-1704 DT denotes the
T8718 1705-1709 NN denotes Ca2+
T8719 1710-1717 NN denotes binding
T8720 1718-1725 NN denotes protein
T8721 1726-1736 NN denotes calmodulin
T8722 1737-1738 -LRB- denotes (
T8723 1738-1741 NN denotes CaM
T8724 1741-1742 -RRB- denotes )
T8725 1742-1743 -COMMA- denotes ,
T8726 1744-1749 WDT denotes which
T8727 1750-1753 VB denotes has
T8728 1754-1758 VB denotes been
T8729 1759-1764 VB denotes shown
T8730 1765-1767 TO denotes to
T8731 1768-1778 RB denotes negatively
T8732 1779-1787 VB denotes regulate
T8733 1788-1793 NN denotes c-Rel
T8734 1794-1798 WRB denotes when
T8735 1799-1808 VB denotes activated
T8736 1809-1810 -LRB- denotes [
T8737 1810-1812 CD denotes 38
T8738 1812-1813 -RRB- denotes ]
T8739 1815-1818 DT denotes The
T8740 1819-1829 NN denotes regulation
T8741 1830-1832 IN denotes of
T8742 1833-1838 NN denotes NF-κB
T8743 1839-1842 CC denotes and
T8744 1843-1847 NN denotes AP-1
T8745 1848-1856 VB denotes observed
T8746 1857-1859 IN denotes in
T8747 1860-1863 DT denotes the
T8748 1864-1871 JJ denotes present
T8749 1872-1877 NN denotes study
T8750 1878-1881 VB denotes was
T8751 1882-1884 IN denotes in
T8752 1885-1894 NN denotes agreement
T8753 1895-1899 IN denotes with
T8754 1900-1907 JJ denotes earlier
T8755 1908-1915 NN denotes studies
T8756 1917-1924 NN denotes T-cells
T8757 1925-1932 VB denotes produce
T8758 1933-1934 DT denotes a
T8759 1935-1940 JJ denotes broad
T8760 1941-1946 NN denotes range
T8761 1947-1949 IN denotes of
T8762 1950-1954 JJ denotes pro-
T8763 1955-1958 CC denotes and
T8764 1959-1976 JJ denotes anti-inflammatory
T8765 1977-1986 NN denotes cytokines
T8766 1986-1987 -COMMA- denotes ,
T8767 1988-1997 VB denotes including
T8768 1998-2002 NN denotes IL-2
T8769 2002-2003 -COMMA- denotes ,
T8770 2004-2008 NN denotes IL-6
T8771 2008-2009 -COMMA- denotes ,
T8772 2010-2015 NN denotes CXCL8
T8773 2015-2016 -COMMA- denotes ,
T8774 2017-2020 NN denotes TNF
T8775 2021-2024 CC denotes and
T8776 2025-2030 NN denotes IL-10
T8777 2030-2031 -COMMA- denotes ,
T8778 2032-2034 IN denotes in
T8779 2035-2043 NN denotes response
T8780 2044-2046 TO denotes to
T8781 2047-2057 NN denotes infections
T8782 2058-2060 CC denotes or
T8783 2061-2066 JJ denotes other
T8784 2067-2073 NN denotes stress
T8785 2074-2081 NN denotes factors
T8786 2082-2083 -LRB- denotes [
T8787 2083-2085 CD denotes 39
T8788 2085-2086 -RRB- denotes ]
T8789 2088-2091 DT denotes The
T8790 2092-2102 NN denotes assessment
T8791 2103-2105 IN denotes of
T8792 2106-2112 NN denotes Jurkat
T8793 2113-2119 NN denotes T-cell
T8794 2120-2132 JJ denotes inflammatory
T8795 2133-2142 NN denotes responses
T8796 2143-2144 -LRB- denotes (
T8797 2144-2149 NN denotes Table
T8798 2150-2151 CD denotes 1
T8799 2151-2152 -RRB- denotes )
T8800 2153-2161 VB denotes revealed
T8801 2162-2164 DT denotes an
T8802 2165-2173 VB denotes enhanced
T8803 2174-2178 NN denotes IL-2
T8804 2179-2189 NN denotes expression
T8805 2190-2194 IN denotes upon
T8806 2195-2203 NN denotes exposure
T8807 2204-2206 TO denotes to
T8808 2207-2210 NN denotes PMA
T8809 2211-2213 CC denotes or
T8810 2214-2216 NN denotes HK
T8811 2217-2219 FW denotes E.
T8812 2220-2224 FW denotes coli
T8813 2225-2228 JJ denotes due
T8814 2229-2231 TO denotes to
T8815 2232-2235 NN denotes PKC
T8816 2236-2246 NN denotes activation
T8817 2247-2248 -LRB- denotes [
T8818 2248-2250 CD denotes 40
T8819 2250-2251 -RRB- denotes ]
T8820 2253-2255 IN denotes In
T8821 2256-2264 NN denotes addition
T8822 2265-2267 TO denotes to
T8823 2268-2271 DT denotes the
T8824 2272-2285 NN denotes transcription
T8825 2286-2292 NN denotes factor
T8826 2293-2298 NN denotes NF-κB
T8827 2298-2299 -COMMA- denotes ,
T8828 2300-2304 NN denotes AP-1
T8829 2305-2312 NN denotes binding
T8830 2313-2318 NN denotes sites
T8831 2319-2323 VB denotes have
T8832 2324-2328 VB denotes been
T8833 2329-2339 VB denotes identified
T8834 2340-2342 IN denotes in
T8835 2343-2346 DT denotes the
T8836 2347-2351 NN denotes IL-6
T8837 2352-2360 NN denotes promoter
T8838 2361-2367 NN denotes region
T8839 2367-2368 -COMMA- denotes ,
T8840 2369-2379 VB denotes indicating
T8841 2380-2388 JJ denotes multiple
T8842 2389-2399 NN denotes regulation
T8843 2400-2401 -LRB- denotes [
T8844 2401-2403 CD denotes 22
T8845 2403-2404 -RRB- denotes ]
T8846 2406-2410 NN denotes AP-1
T8847 2411-2414 CC denotes and
T8848 2415-2420 NN denotes NF-κB
T8849 2421-2425 VB denotes have
T8850 2426-2430 RB denotes also
T8851 2431-2435 VB denotes been
T8852 2436-2448 VB denotes demonstrated
T8853 2449-2451 TO denotes to
T8854 2452-2460 VB denotes regulate
T8855 2461-2466 NN denotes CXCL8
T8856 2467-2477 NN denotes expression
T8857 2478-2484 IN denotes during
T8858 2485-2494 NN denotes induction
T8859 2495-2497 IN denotes of
T8860 2498-2510 JJ denotes inflammatory
T8861 2511-2520 NN denotes responses
T8862 2521-2523 IN denotes in
T8863 2524-2531 NN denotes T-cells
T8864 2532-2533 -LRB- denotes [
T8865 2533-2535 CD denotes 12
T8866 2535-2536 -RRB- denotes ]
T8867 2538-2549 RB denotes Furthermore
T8868 2549-2550 -COMMA- denotes ,
T8869 2551-2555 NN denotes IL-6
T8870 2556-2559 CC denotes and
T8871 2560-2565 NN denotes CXCL8
T8872 2566-2581 NN denotes gene-expression
T8873 2582-2584 VB denotes is
T8874 2585-2595 VB denotes associated
T8875 2596-2600 IN denotes with
T8876 2601-2603 DT denotes an
T8877 2604-2609 JJ denotes early
T8878 2610-2616 JJ denotes immune
T8879 2617-2625 NN denotes response
T8880 2626-2628 IN denotes in
T8881 2629-2635 NN denotes Jurkat
T8882 2636-2643 NN denotes T-cells
T8883 2644-2645 -LRB- denotes [
T8884 2645-2647 CD denotes 41
T8885 2647-2648 -RRB- denotes ]
T8886 2650-2652 IN denotes In
T8887 2653-2656 DT denotes the
T8888 2657-2664 JJ denotes present
T8889 2665-2670 NN denotes study
T8890 2670-2671 -COMMA- denotes ,
T8891 2672-2676 CC denotes both
T8892 2677-2680 NN denotes PMA
T8893 2681-2684 CC denotes and
T8894 2685-2687 NN denotes HK
T8895 2688-2690 NNP denotes E.
T8896 2691-2695 FW denotes coli
T8897 2696-2704 VB denotes resulted
T8898 2705-2707 IN denotes in
T8899 2708-2718 JJ denotes comparable
T8900 2719-2728 NN denotes increases
T8901 2729-2731 IN denotes in
T8902 2732-2736 NN denotes IL-6
T8903 2737-2742 IN denotes while
T8904 2743-2746 NN denotes PMA
T8905 2747-2750 VB denotes was
T8906 2751-2755 RB denotes more
T8907 2756-2762 JJ denotes potent
T8908 2763-2765 IN denotes at
T8909 2766-2776 VB denotes activating
T8910 2777-2782 NN denotes CXCL8
T8911 2783-2790 NN denotes release
T8912 2792-2795 NN denotes PMA
T8913 2796-2799 CC denotes and
T8914 2800-2802 NN denotes HK
T8915 2803-2805 FW denotes E.
T8916 2806-2810 FW denotes coli
T8917 2811-2820 NN denotes treatment
T8918 2821-2825 RB denotes also
T8919 2826-2833 VB denotes induced
T8920 2834-2837 NN denotes TNF
T8921 2838-2848 NN denotes expression
T8922 2850-2853 NN denotes TNF
T8923 2854-2856 VB denotes is
T8924 2857-2860 CD denotes one
T8925 2861-2863 IN denotes of
T8926 2864-2867 DT denotes the
T8927 2868-2873 JJ denotes first
T8928 2874-2883 NN denotes cytokines
T8929 2884-2891 VB denotes induced
T8930 2892-2894 IN denotes by
T8931 2895-2902 NN denotes T-cells
T8932 2903-2904 -LRB- denotes [
T8933 2904-2906 CD denotes 42
T8934 2906-2907 -RRB- denotes ]
T8935 2908-2911 CC denotes and
T8936 2912-2915 PRP-DOLLAR- denotes its
T8937 2916-2926 NN denotes expression
T8938 2927-2929 VB denotes is
T8939 2930-2939 VB denotes regulated
T8940 2940-2942 IN denotes by
T8941 2943-2954 NN denotes calcineurin
T8942 2954-2955 -COMMA- denotes ,
T8943 2956-2960 NN denotes NFAT
T8944 2961-2964 CC denotes and
T8945 2965-2974 NN denotes ATF-2/Jun
T8946 2975-2976 -LRB- denotes [
T8947 2976-2978 CD denotes 20
T8948 2978-2979 -RRB- denotes ]
T8949 2981-2988 RB denotes However
T8950 2988-2989 -COMMA- denotes ,
T8951 2990-3004 JJ denotes PMA-stimulated
T8952 3005-3011 NN denotes Jurkat
T8953 3012-3019 NN denotes T-cells
T8954 3020-3026 VB denotes showed
T8955 3027-3029 DT denotes no
T8956 3030-3040 NN denotes difference
T8957 3041-3043 IN denotes in
T8958 3044-3049 NN denotes IL-10
T8959 3050-3060 NN denotes expression
T8960 3061-3071 VB denotes indicating
T8961 3072-3074 DT denotes an
T8962 3075-3082 VB denotes induced
T8963 3083-3095 JJ denotes inflammatory
T8964 3096-3104 NN denotes response
T8965 3106-3108 NN denotes HK
T8966 3109-3111 FW denotes E.
T8967 3112-3116 FW denotes coli
T8968 3117-3126 NN denotes treatment
T8969 3127-3135 VB denotes resulted
T8970 3136-3138 IN denotes in
T8971 3139-3140 DT denotes a
T8972 3141-3152 JJ denotes significant
T8973 3153-3162 NN denotes reduction
T8974 3163-3165 IN denotes of
T8975 3166-3171 NN denotes IL-10
T8976 3172-3182 NN denotes expression
T8977 3184-3187 DT denotes The
T8978 3188-3205 JJ denotes anti-inflammatory
T8979 3206-3214 NN denotes cytokine
T8980 3215-3220 NN denotes IL-10
T8981 3221-3223 VB denotes is
T8982 3224-3229 VB denotes known
T8983 3230-3232 TO denotes to
T8984 3233-3240 VB denotes inhibit
T8985 3241-3247 NN denotes T-cell
T8986 3248-3258 NN denotes activation
T8987 3258-3259 -COMMA- denotes ,
T8988 3260-3273 NN denotes proliferation
T8989 3274-3277 CC denotes and
T8990 3278-3281 DT denotes the
T8991 3282-3292 NN denotes expression
T8992 3293-3295 IN denotes of
T8993 3296-3312 JJ denotes pro-inflammatory
T8994 3313-3322 NN denotes cytokines
T8995 3322-3323 -COMMA- denotes ,
T8996 3324-3328 JJ denotes such
T8997 3329-3331 IN denotes as
T8998 3332-3336 NN denotes IL-2
T8999 3336-3337 -COMMA- denotes ,
T9000 3338-3342 NN denotes IL-5
T9001 3343-3346 CC denotes and
T9002 3347-3352 NN denotes INF-γ
T9003 3353-3354 -LRB- denotes [
T9004 3354-3359 CD denotes 39,43
T9005 3359-3360 -RRB- denotes ]
T9006 3361-3364 CC denotes and
T9007 3365-3373 VB denotes regulate
T9008 3374-3386 JJ denotes inflammatory
T9009 3387-3396 NN denotes responses
T9010 3397-3399 IN denotes by
T9011 3400-3408 VB denotes inducing
T9012 3409-3415 NN denotes T-cell
T9013 3416-3422 NN denotes anergy
T9014 3423-3424 -LRB- denotes [
T9015 3424-3426 CD denotes 44
T9016 3426-3427 -RRB- denotes ]
T9017 3429-3432 DT denotes The
T9018 3433-3437 NN denotes time
T9019 3438-3444 NN denotes course
T9020 3445-3453 NN denotes analysis
T9021 3454-3456 IN denotes of
T9022 3457-3465 NN denotes cytokine
T9023 3466-3476 NN denotes expression
T9024 3477-3483 VB denotes showed
T9025 3484-3485 DT denotes a
T9026 3486-3497 NN denotes correlation
T9027 3498-3505 IN denotes between
T9028 3506-3510 NN denotes AP-1
T9029 3511-3514 CC denotes and
T9030 3515-3518 DT denotes the
T9031 3519-3528 NN denotes chemokine
T9032 3529-3534 NN denotes CXCL8
T9033 3535-3540 WRB denotes where
T9034 3541-3546 NN denotes CXCL8
T9035 3547-3557 NN denotes expression
T9036 3558-3561 VB denotes was
T9037 3562-3575 RB denotes significantly
T9038 3576-3584 VB denotes elevated
T9039 3585-3592 RB denotes already
T9040 3593-3595 IN denotes at
T9041 3596-3599 CD denotes 2-6
T9042 3600-3601 NN denotes h
T9043 3602-3607 IN denotes after
T9044 3608-3611 NN denotes PMA
T9045 3612-3620 NN denotes exposure
T9046 3622-3625 DT denotes The
T9047 3626-3631 NN denotes CXCL8
T9048 3632-3642 NN denotes expression
T9049 3643-3646 VB denotes did
T9050 3647-3650 RB denotes not
T9051 3651-3660 VB denotes correlate
T9052 3661-3665 IN denotes with
T9053 3666-3669 DT denotes the
T9054 3670-3675 JJ denotes early
T9055 3676-3681 NN denotes NF-κB
T9056 3682-3692 NN denotes activation
T9057 3693-3694 -LRB- denotes (
T9058 3694-3695 CD denotes 1
T9059 3696-3699 NN denotes min
T9060 3699-3700 -RRB- denotes )
T9061 3701-3703 CC denotes or
T9062 3704-3708 IN denotes with
T9063 3709-3712 DT denotes the
T9064 3713-3728 NN denotes down-regulation
T9065 3729-3731 IN denotes of
T9066 3732-3737 NN denotes NF-κB
T9067 3738-3740 IN denotes at
T9068 3741-3742 CD denotes 2
T9069 3743-3744 NN denotes h
T9070 3745-3749 NN denotes post
T9071 3750-3758 NN denotes exposure
T9072 3760-3764 CC denotes Both
T9073 3765-3769 NN denotes IL-6
T9074 3770-3773 CC denotes and
T9075 3774-3777 NN denotes TNF
T9076 3778-3788 NN denotes expression
T9077 3789-3793 VB denotes were
T9078 3794-3796 RB denotes up
T9079 3797-3806 VB denotes regulated
T9080 3807-3814 IN denotes between
T9081 3815-3819 CD denotes 6-24
T9082 3820-3821 NN denotes h
T9083 3823-3829 IN denotes During
T9084 3830-3834 DT denotes this
T9085 3835-3841 NN denotes period
T9086 3841-3842 -COMMA- denotes ,
T9087 3843-3848 NN denotes NF-κB
T9088 3849-3858 VB denotes increased
T9089 3859-3863 IN denotes from
T9090 3864-3867 PRP-DOLLAR- denotes its
T9091 3868-3875 JJ denotes minimum
T9092 3876-3881 NN denotes level
T9093 3882-3884 IN denotes at
T9094 3885-3886 CD denotes 6
T9095 3887-3888 NN denotes h
T9096 3890-3893 NN denotes PKC
T9097 3894-3897 VB denotes has
T9098 3898-3902 VB denotes been
T9099 3903-3908 VB denotes shown
T9100 3909-3911 TO denotes to
T9101 3912-3914 VB denotes be
T9102 3915-3925 VB denotes associated
T9103 3926-3930 IN denotes with
T9104 3931-3934 DT denotes the
T9105 3935-3945 NN denotes activation
T9106 3946-3948 IN denotes of
T9107 3949-3953 NN denotes AP-1
T9108 3953-3954 -COMMA- denotes ,
T9109 3955-3958 CC denotes but
T9110 3959-3962 RB denotes not
T9111 3963-3967 IN denotes with
T9112 3968-3973 NN denotes NF-κB
T9113 3974-3984 NN denotes activation
T9114 3985-3987 IN denotes of
T9115 3988-3991 DT denotes the
T9116 3992-3996 NN denotes IL-2
T9117 3997-4005 NN denotes promoter
T9118 4006-4007 -LRB- denotes [
T9119 4007-4009 CD denotes 45
T9120 4009-4010 -RRB- denotes ]
T9121 4012-4020 NN denotes Mutation
T9122 4021-4023 IN denotes of
T9123 4024-4027 DT denotes the
T9124 4028-4033 NN denotes NF-κB
T9125 4034-4038 NN denotes site
T9126 4039-4042 VB denotes did
T9127 4043-4046 RB denotes not
T9128 4047-4053 VB denotes affect
T9129 4054-4058 NN denotes IL-2
T9130 4059-4069 NN denotes expression
T9131 4069-4070 -COMMA- denotes ,
T9132 4071-4078 IN denotes whereas
T9133 4079-4087 NN denotes mutation
T9134 4088-4090 IN denotes of
T9135 4091-4094 DT denotes the
T9136 4095-4099 NN denotes AP-1
T9137 4100-4104 NN denotes site
T9138 4105-4107 CC denotes or
T9139 4108-4111 NN denotes PKC
T9140 4112-4121 NN denotes depletion
T9141 4122-4128 RB denotes almost
T9142 4129-4136 VB denotes revoked
T9143 4137-4141 NN denotes IL-2
T9144 4142-4149 NN denotes release
T9145 4151-4156 DT denotes These
T9146 4157-4169 NN denotes observations
T9147 4170-4178 VB denotes indicate
T9148 4179-4183 IN denotes that
T9149 4184-4187 DT denotes the
T9150 4188-4192 NN denotes MAPK
T9151 4193-4200 NN denotes pathway
T9152 4201-4204 CC denotes and
T9153 4205-4208 DT denotes the
T9154 4209-4222 NN denotes transcription
T9155 4223-4229 NN denotes factor
T9156 4230-4234 NN denotes AP-1
T9157 4235-4239 VB denotes play
T9158 4240-4242 DT denotes an
T9159 4243-4252 JJ denotes important
T9160 4253-4257 NN denotes role
T9161 4258-4260 IN denotes in
T9162 4261-4264 DT denotes the
T9163 4265-4274 NN denotes induction
T9164 4275-4277 IN denotes of
T9165 4278-4290 JJ denotes inflammatory
T9166 4291-4300 NN denotes responses
T9167 4301-4303 IN denotes in
T9168 4304-4310 NN denotes Jurkat
T9169 4311-4318 NN denotes T-cells
T9170 4319-4320 -LRB- denotes [
T9171 4320-4328 CD denotes 12,20,22
T9172 4328-4329 -RRB- denotes ]
T9173 4331-4334 DT denotes The
T9174 4335-4343 VB denotes obtained
T9175 4344-4351 NN denotes results
T9176 4352-4359 VB denotes signify
T9177 4360-4364 IN denotes that
T9178 4365-4370 NN denotes CXCL8
T9179 4371-4374 VB denotes was
T9180 4375-4384 RB denotes primarily
T9181 4385-4394 VB denotes regulated
T9182 4395-4402 IN denotes through
T9183 4403-4406 DT denotes the
T9184 4407-4411 NN denotes MAPK
T9185 4412-4419 NN denotes pathway
T9186 4421-4424 DT denotes The
T9187 4425-4430 NN denotes NF-κB
T9188 4431-4441 NN denotes activation
T9189 4442-4451 NN denotes inhibitor
T9190 4452-4453 -LRB- denotes (
T9191 4453-4456 NN denotes NAI
T9192 4456-4457 -RRB- denotes )
T9193 4458-4464 VB denotes showed
T9194 4465-4476 NN denotes specificity
T9195 4477-4484 IN denotes against
T9196 4485-4490 NN denotes NF-κB
T9197 4491-4494 CC denotes and
T9198 4495-4503 VB denotes resulted
T9199 4504-4506 IN denotes in
T9200 4507-4508 DT denotes a
T9201 4509-4517 JJ denotes complete
T9202 4518-4522 NN denotes IL-6
T9203 4523-4533 NN denotes inhibition
T9204 4534-4543 VB denotes following
T9205 4544-4553 NN denotes induction
T9206 4554-4558 IN denotes with
T9207 4559-4562 NN denotes PMA
T9208 4563-4566 CC denotes and
T9209 4567-4578 JJ denotes significant
T9210 4579-4583 NN denotes IL-6
T9211 4584-4593 NN denotes reduction
T9212 4594-4599 IN denotes after
T9213 4600-4602 NN denotes HK
T9214 4603-4605 FW denotes E.
T9215 4606-4610 FW denotes coli
T9216 4611-4620 NN denotes treatment
T9217 4622-4627 NN denotes CXCL8
T9218 4628-4631 VB denotes was
T9219 4632-4638 RB denotes highly
T9220 4639-4641 RB denotes up
T9221 4642-4651 VB denotes regulated
T9222 4652-4654 IN denotes by
T9223 4655-4658 NN denotes PMA
T9224 4659-4662 CC denotes and
T9225 4663-4666 DT denotes the
T9226 4667-4675 NN denotes addition
T9227 4676-4678 IN denotes of
T9228 4679-4682 NN denotes NAI
T9229 4683-4691 VB denotes resulted
T9230 4692-4694 IN denotes in
T9231 4695-4696 DT denotes a
T9232 4697-4702 JJ denotes minor
T9233 4703-4712 NN denotes reduction
T9234 4713-4715 IN denotes in
T9235 4716-4721 NN denotes CXCL8
T9236 4722-4732 NN denotes expression
T9237 4734-4745 RB denotes Furthermore
T9238 4745-4746 -COMMA- denotes ,
T9239 4747-4752 NN denotes CXCL8
T9240 4753-4763 NN denotes expression
T9241 4764-4767 VB denotes was
T9242 4768-4771 RB denotes not
T9243 4772-4780 VB denotes affected
T9244 4781-4783 IN denotes by
T9245 4784-4787 NN denotes NAI
T9246 4788-4797 VB denotes following
T9247 4798-4800 NN denotes HK
T9248 4801-4803 FW denotes E.
T9249 4804-4808 FW denotes coli
T9250 4809-4818 NN denotes treatment
T9251 4818-4819 -COMMA- denotes ,
T9252 4820-4830 VB denotes indicating
T9253 4831-4832 DT denotes a
T9254 4833-4837 NN denotes lack
T9255 4838-4840 IN denotes of
T9256 4841-4852 NN denotes correlation
T9257 4853-4860 IN denotes between
T9258 4861-4866 NN denotes CXCL8
T9259 4867-4870 CC denotes and
T9260 4871-4876 NN denotes NF-κB
T9261 4878-4885 JJ denotes Further
T9262 4886-4894 NN denotes analysis
T9263 4895-4897 IN denotes of
T9264 4898-4903 NN denotes CXCL8
T9265 4904-4914 NN denotes expression
T9266 4915-4923 VB denotes revealed
T9267 4924-4925 DT denotes a
T9268 4926-4941 NN denotes down-regulation
T9269 4942-4944 IN denotes by
T9270 4945-4949 NN denotes PKC-
T9271 4950-4953 CC denotes and
T9272 4954-4958 NN denotes JNK-
T9273 4959-4969 NN denotes inhibitors
T9274 4969-4970 -COMMA- denotes ,
T9275 4971-4981 VB denotes suggesting
T9276 4982-4984 DT denotes an
T9277 4985-4996 NN denotes involvement
T9278 4997-4999 IN denotes of
T9279 5000-5004 NN denotes AP-1
T9280 5005-5008 IN denotes via
T9281 5009-5012 NN denotes PKC
T9282 5013-5016 CC denotes and
T9283 5017-5020 NN denotes JNK
T9284 5020-5021 -COMMA- denotes ,
T9285 5022-5034 RB denotes respectively
T9286 5036-5044 NN denotes Analysis
T9287 5045-5047 IN denotes of
T9288 5048-5052 NN denotes gene
T9289 5053-5063 NN denotes expression
T9290 5064-5071 RB denotes further
T9291 5072-5081 VB denotes confirmed
T9292 5082-5086 IN denotes that
T9293 5087-5091 NN denotes il-6
T9294 5092-5095 CC denotes and
T9295 5096-5101 NN denotes cxcl8
T9296 5102-5106 VB denotes were
T9297 5107-5118 VB denotes upregulated
T9298 5119-5121 IN denotes by
T9299 5122-5125 NN denotes PMA
T9300 5127-5137 NN denotes Expression
T9301 5138-5140 IN denotes of
T9302 5141-5145 NN denotes il-6
T9303 5146-5153 VB denotes dropped
T9304 5154-5159 IN denotes below
T9305 5160-5165 JJ denotes basal
T9306 5166-5172 NN denotes levels
T9307 5173-5182 VB denotes following
T9308 5183-5193 NN denotes inhibition
T9309 5194-5196 IN denotes of
T9310 5197-5202 NN denotes NF-κB
T9311 5203-5206 CC denotes and
T9312 5207-5210 NN denotes JNK
T9313 5211-5218 IN denotes whereas
T9314 5219-5224 NN denotes cxcl8
T9315 5225-5233 VB denotes remained
T9316 5234-5242 JJ denotes elevated
T9317 5243-5248 IN denotes above
T9318 5249-5254 JJ denotes basal
T9319 5255-5261 NN denotes levels
T9320 5262-5263 -LRB- denotes (
T9321 5263-5272 RB denotes 16.5-fold
T9322 5273-5276 CC denotes and
T9323 5277-5285 JJ denotes 7.1-fold
T9324 5286-5298 RB denotes respectively
T9325 5298-5299 -RRB- denotes )
T9326 5300-5309 VB denotes following
T9327 5310-5313 DT denotes the
T9328 5314-5318 JJ denotes same
T9329 5319-5328 NN denotes treatment
T9330 5330-5341 RB denotes Furthermore
T9331 5341-5342 -COMMA- denotes ,
T9332 5343-5353 NN denotes inhibition
T9333 5354-5356 IN denotes of
T9334 5357-5360 NN denotes PKC
T9335 5361-5364 VB denotes did
T9336 5365-5368 RB denotes not
T9337 5369-5375 VB denotes result
T9338 5376-5378 IN denotes in
T9339 5379-5380 DT denotes a
T9340 5381-5392 JJ denotes significant
T9341 5393-5401 NN denotes decrease
T9342 5402-5404 IN denotes of
T9343 5405-5409 NN denotes il-6
T9344 5410-5412 CC denotes or
T9345 5413-5418 NN denotes cxcl8
T9346 5418-5419 -COMMA- denotes ,
T9347 5420-5425 WDT denotes which
T9348 5426-5428 VB denotes is
T9349 5429-5431 IN denotes in
T9350 5432-5442 NN denotes accordance
T9351 5443-5447 IN denotes with
T9352 5448-5455 NN denotes protein
T9353 5456-5460 NN denotes data
T9354 5461-5462 -LRB- denotes (
T9355 5462-5468 NN denotes figure
T9356 5469-5470 CD denotes 6
T9357 5470-5471 -RRB- denotes )
T9358 5473-5478 DT denotes These
T9359 5479-5486 NN denotes results
T9360 5487-5494 VB denotes suggest
T9361 5495-5499 IN denotes that
T9362 5500-5505 NN denotes NF-κB
T9363 5506-5508 VB denotes is
T9364 5509-5517 VB denotes involved
T9365 5518-5520 IN denotes in
T9366 5521-5525 NN denotes IL-6
T9367 5526-5536 NN denotes regulation
T9368 5537-5540 CC denotes and
T9369 5541-5548 NN denotes release
T9370 5549-5554 IN denotes while
T9371 5555-5557 PRP denotes it
T9372 5558-5560 VB denotes is
T9373 5561-5564 RB denotes not
T9374 5565-5573 VB denotes required
T9375 5574-5577 IN denotes for
T9376 5578-5581 DT denotes the
T9377 5582-5592 NN denotes expression
T9378 5593-5595 IN denotes of
T9379 5596-5601 NN denotes CXCL8
T9380 5602-5604 IN denotes in
T9381 5605-5611 NN denotes Jurkat
T9382 5612-5613 NN denotes T
T9383 5614-5619 NN denotes cells
T9384 5621-5624 DT denotes The
T9385 5625-5638 NN denotes transcription
T9386 5639-5645 NN denotes factor
T9387 5646-5651 NN denotes NF-κB
T9388 5652-5654 VB denotes is
T9389 5655-5666 JJ denotes responsible
T9390 5667-5670 IN denotes for
T9391 5671-5672 DT denotes a
T9392 5673-5678 JJ denotes rapid
T9393 5679-5685 JJ denotes immune
T9394 5686-5694 NN denotes response
T9395 5695-5700 WDT denotes which
T9396 5701-5703 VB denotes is
T9397 5704-5712 VB denotes followed
T9398 5713-5715 IN denotes by
T9399 5716-5718 DT denotes an
T9400 5719-5727 NN denotes increase
T9401 5728-5730 IN denotes in
T9402 5731-5744 NN denotes transcription
T9403 5745-5747 IN denotes of
T9404 5748-5751 NN denotes IκB
T9405 5752-5756 RB denotes thus
T9406 5757-5767 VB denotes inhibiting
T9407 5768-5773 NN denotes NF-κB
T9408 5774-5775 -LRB- denotes [
T9409 5775-5777 CD denotes 46
T9410 5777-5778 -RRB- denotes ]
T9411 5780-5790 NN denotes Activation
T9412 5791-5793 IN denotes of
T9413 5794-5799 NN denotes NF-κB
T9414 5800-5802 IN denotes in
T9415 5803-5809 NN denotes Jurkat
T9416 5810-5817 NN denotes T-cells
T9417 5818-5820 VB denotes is
T9418 5821-5830 JJ denotes dependent
T9419 5831-5833 IN denotes on
T9420 5834-5839 NN denotes Bcl10
T9421 5840-5850 NN denotes activation
T9422 5850-5851 -COMMA- denotes ,
T9423 5852-5857 WDT denotes which
T9424 5858-5860 IN denotes in
T9425 5861-5865 NN denotes turn
T9426 5866-5868 VB denotes is
T9427 5869-5878 VB denotes regulated
T9428 5879-5881 IN denotes by
T9429 5882-5885 NN denotes PKC
T9430 5887-5893 JJ denotes Recent
T9431 5894-5901 NN denotes studies
T9432 5902-5906 VB denotes have
T9433 5907-5918 VB denotes established
T9434 5919-5922 DT denotes the
T9435 5923-5933 NN denotes importance
T9436 5934-5936 IN denotes of
T9437 5937-5938 DT denotes a
T9438 5939-5946 NN denotes protein
T9439 5947-5954 NN denotes complex
T9440 5955-5965 VB denotes consisting
T9441 5966-5968 IN denotes of
T9442 5969-5975 NN denotes CARMA1
T9443 5975-5976 -COMMA- denotes ,
T9444 5977-5982 NN denotes Bcl10
T9445 5983-5986 CC denotes and
T9446 5987-5992 NN denotes MALT1
T9447 5993-5994 -LRB- denotes (
T9448 5994-5997 NN denotes CBM
T9449 5997-5998 -RRB- denotes )
T9450 5998-5999 -COMMA- denotes ,
T9451 6000-6002 IN denotes in
T9452 6003-6006 DT denotes the
T9453 6007-6016 NN denotes induction
T9454 6017-6019 IN denotes of
T9455 6020-6025 NN denotes NF-κB
T9456 6027-6040 VB denotes Investigating
T9457 6041-6046 NN denotes Bcl10
T9458 6046-6047 -COMMA- denotes ,
T9459 6048-6060 NNP denotes Scharschmidt
T9460 6061-6064 CC denotes and
T9461 6065-6075 NN denotes colleagues
T9462 6076-6077 -LRB- denotes [
T9463 6077-6079 CD denotes 47
T9464 6079-6080 -RRB- denotes ]
T9465 6081-6093 VB denotes demonstrated
T9466 6094-6098 IN denotes that
T9467 6099-6101 PRP denotes it
T9468 6102-6104 VB denotes is
T9469 6105-6106 DT denotes a
T9470 6107-6115 JJ denotes critical
T9471 6116-6125 NN denotes regulator
T9472 6126-6128 IN denotes of
T9473 6129-6134 NN denotes NF-κB
T9474 6135-6143 NN denotes activity
T9475 6145-6160 NN denotes Down-regulation
T9476 6161-6163 IN denotes of
T9477 6164-6169 NN denotes Bcl10
T9478 6170-6174 IN denotes from
T9479 6175-6182 NN denotes signals
T9480 6183-6193 VB denotes transduced
T9481 6194-6197 IN denotes via
T9482 6198-6201 DT denotes the
T9483 6202-6210 NN denotes TCR/CD28
T9484 6211-6214 CC denotes and
T9485 6215-6218 NN denotes PKC
T9486 6219-6227 VB denotes resulted
T9487 6228-6230 IN denotes in
T9488 6231-6232 DT denotes a
T9489 6233-6244 JJ denotes concomitant
T9490 6245-6260 NN denotes down-regulation
T9491 6261-6263 IN denotes of
T9492 6264-6269 NN denotes NF-κB
T9493 6271-6275 PRP denotes They
T9494 6276-6285 VB denotes suggested
T9495 6286-6290 IN denotes that
T9496 6291-6296 NN denotes Bcl10
T9497 6297-6299 VB denotes is
T9498 6300-6309 RB denotes initially
T9499 6310-6319 VB denotes activated
T9500 6320-6322 IN denotes by
T9501 6323-6330 NN denotes TCR/PKC
T9502 6331-6334 CC denotes but
T9503 6335-6339 IN denotes that
T9504 6340-6349 JJ denotes continued
T9505 6350-6360 NN denotes activation
T9506 6361-6362 -LRB- denotes (
T9507 6362-6363 SYM denotes >
T9508 6363-6364 CD denotes 1
T9509 6365-6366 NN denotes h
T9510 6366-6367 -RRB- denotes )
T9511 6368-6376 VB denotes promotes
T9512 6377-6380 PRP-DOLLAR- denotes its
T9513 6381-6392 NN denotes degradation
T9514 6394-6401 NN denotes Narayan
T9515 6402-6405 CC denotes and
T9516 6406-6416 NN denotes colleagues
T9517 6417-6418 -LRB- denotes [
T9518 6418-6420 CD denotes 27
T9519 6420-6421 -RRB- denotes ]
T9520 6422-6431 VB denotes suggested
T9521 6432-6436 IN denotes that
T9522 6437-6445 NN denotes deletion
T9523 6446-6448 IN denotes in
T9524 6449-6452 DT denotes any
T9525 6453-6455 IN denotes of
T9526 6456-6459 DT denotes the
T9527 6460-6465 CD denotes three
T9528 6466-6469 NN denotes CBM
T9529 6470-6477 NN denotes complex
T9530 6478-6486 NN denotes proteins
T9531 6487-6494 VB denotes impairs
T9532 6495-6511 JJ denotes antigen-receptor
T9533 6512-6521 JJ denotes dependent
T9534 6522-6532 NN denotes activation
T9535 6533-6535 IN denotes of
T9536 6536-6541 NN denotes NF-κB
T9537 6543-6547 PRP denotes They
T9538 6548-6554 VB denotes showed
T9539 6555-6559 IN denotes that
T9540 6560-6565 NN denotes NF-κB
T9541 6566-6576 NN denotes activation
T9542 6577-6580 IN denotes via
T9543 6581-6584 NN denotes Akt
T9544 6585-6593 VB denotes requires
T9545 6594-6600 NN denotes CARMA1
T9546 6601-6604 CC denotes and
T9547 6605-6609 VB denotes acts
T9548 6610-6612 IN denotes in
T9549 6613-6624 NN denotes cooperation
T9550 6625-6629 IN denotes with
T9551 6630-6633 NN denotes PKC
T9552 6634-6643 VB denotes following
T9553 6644-6654 JJ denotes short-term
T9554 6655-6663 NN denotes exposure
T9555 6664-6665 -LRB- denotes (
T9556 6665-6667 CD denotes 30
T9557 6668-6671 NN denotes min
T9558 6671-6672 -RRB- denotes )
T9559 6673-6675 IN denotes of
T9560 6676-6682 NN denotes Jurkat
T9561 6683-6690 NN denotes T-cells
T9562 6691-6695 IN denotes with
T9563 6696-6699 NN denotes PMA
T9564 6701-6704 NN denotes Akt
T9565 6705-6719 VB denotes phosphorylates
T9566 6720-6723 CC denotes and
T9567 6724-6728 RB denotes thus
T9568 6729-6738 VB denotes activates
T9569 6739-6744 NN denotes Bcl10
T9570 6746-6751 DT denotes These
T9571 6752-6759 NN denotes studies
T9572 6760-6768 VB denotes indicate
T9573 6769-6773 IN denotes that
T9574 6774-6777 NN denotes PKC
T9575 6778-6780 VB denotes is
T9576 6781-6788 JJ denotes crucial
T9577 6789-6792 IN denotes for
T9578 6793-6798 NN denotes NF-κB
T9579 6799-6809 NN denotes activation
T9580 6810-6819 VB denotes following
T9581 6820-6830 JJ denotes short-term
T9582 6831-6840 NN denotes treatment
T9583 6841-6848 IN denotes through
T9584 6849-6856 NN denotes signals
T9585 6857-6860 IN denotes via
T9586 6861-6869 NN denotes membrane
T9587 6870-6875 VB denotes bound
T9588 6876-6885 NN denotes receptors
T9589 6886-6890 JJ denotes such
T9590 6891-6893 IN denotes as
T9591 6894-6897 DT denotes the
T9592 6898-6901 NN denotes TCR
T9593 6902-6905 CC denotes and
T9594 6906-6909 DT denotes the
T9595 6910-6924 JJ denotes co-stimulatory
T9596 6925-6933 NN denotes receptor
T9597 6934-6938 NN denotes CD28
T9598 6940-6944 RB denotes Thus
T9599 6944-6945 -COMMA- denotes ,
T9600 6946-6949 DT denotes the
T9601 6950-6953 NN denotes CBM
T9602 6954-6961 NN denotes complex
T9603 6962-6970 NN denotes proteins
T9604 6971-6975 VB denotes play
T9605 6976-6977 DT denotes a
T9606 6978-6981 JJ denotes key
T9607 6982-6986 NN denotes role
T9608 6987-6989 IN denotes in
T9609 6990-6994 DT denotes this
T9610 6995-7005 NN denotes signalling
T9611 7006-7013 NN denotes process
T9612 7015-7018 NN denotes PMA
T9613 7019-7027 VB denotes diffuses
T9614 7028-7032 IN denotes into
T9615 7033-7036 DT denotes the
T9616 7037-7044 NN denotes cytosol
T9617 7045-7048 CC denotes and
T9618 7049-7057 RB denotes directly
T9619 7058-7067 VB denotes activates
T9620 7068-7071 NN denotes PKC
T9621 7072-7077 IN denotes since
T9622 7078-7080 PRP denotes it
T9623 7081-7083 VB denotes is
T9624 7084-7086 DT denotes an
T9625 7087-7095 NN denotes analogue
T9626 7096-7098 TO denotes to
T9627 7099-7113 NN denotes diacylglycerol
T9628 7114-7115 -LRB- denotes [
T9629 7115-7117 CD denotes 48
T9630 7117-7118 -RRB- denotes ]
T9631 7120-7127 JJ denotes Several
T9632 7128-7135 NN denotes studies
T9633 7136-7140 VB denotes have
T9634 7141-7153 VB denotes demonstrated
T9635 7154-7158 IN denotes that
T9636 7159-7169 NN denotes inhibition
T9637 7170-7172 IN denotes of
T9638 7173-7176 NN denotes PKC
T9639 7177-7183 VB denotes blocks
T9640 7184-7189 NN denotes NF-κB
T9641 7190-7193 CC denotes and
T9642 7194-7198 NN denotes AP-1
T9643 7199-7207 NN denotes activity
T9644 7207-7208 -COMMA- denotes ,
T9645 7209-7219 VB denotes suggesting
T9646 7220-7221 DT denotes a
T9647 7222-7228 JJ denotes direct
T9648 7229-7239 NN denotes regulation
T9649 7240-7242 IN denotes of
T9650 7243-7248 DT denotes these
T9651 7249-7262 NN denotes transcription
T9652 7263-7270 NN denotes factors
T9653 7271-7273 IN denotes by
T9654 7274-7277 NN denotes PKC
T9655 7278-7279 -LRB- denotes [
T9656 7279-7284 CD denotes 49,50
T9657 7284-7285 -RRB- denotes ]
T9658 7287-7290 NN denotes PKC
T9659 7291-7293 VB denotes is
T9660 7294-7303 VB denotes activated
T9661 7304-7306 IN denotes at
T9662 7307-7309 DT denotes an
T9663 7310-7315 JJ denotes early
T9664 7316-7321 NN denotes stage
T9665 7322-7331 VB denotes following
T9666 7332-7338 NN denotes T-cell
T9667 7339-7350 NN denotes stimulation
T9668 7351-7354 CC denotes and
T9669 7355-7357 VB denotes is
T9670 7358-7367 RB denotes therefore
T9671 7368-7370 DT denotes an
T9672 7371-7380 JJ denotes important
T9673 7381-7390 NN denotes regulator
T9674 7391-7393 IN denotes of
T9675 7394-7404 JJ denotes downstream
T9676 7405-7417 JJ denotes inflammatory
T9677 7418-7428 NN denotes signalling
T9678 7429-7437 NN denotes pathways
T9679 7438-7445 VB denotes leading
T9680 7446-7448 TO denotes to
T9681 7449-7457 NN denotes cytokine
T9682 7458-7468 NN denotes expression
T9683 7469-7470 -LRB- denotes [
T9684 7470-7472 CD denotes 50
T9685 7472-7473 -RRB- denotes ]
T9686 7475-7477 PRP denotes We
T9687 7478-7482 VB denotes have
T9688 7483-7488 VB denotes shown
T9689 7489-7493 IN denotes that
T9690 7494-7512 NN denotes phosphorylated-PKC
T9691 7513-7515 VB denotes is
T9692 7516-7518 RB denotes up
T9693 7519-7528 VB denotes regulated
T9694 7529-7531 IN denotes in
T9695 7532-7540 NN denotes response
T9696 7541-7543 TO denotes to
T9697 7544-7547 NN denotes PMA
T9698 7548-7551 CC denotes and
T9699 7552-7554 NN denotes HK
T9700 7555-7557 FW denotes E.
T9701 7558-7562 FW denotes coli
T9702 7562-7563 -COMMA- denotes ,
T9703 7564-7574 VB denotes indicating
T9704 7575-7577 DT denotes an
T9705 7578-7589 NN denotes association
T9706 7590-7597 IN denotes between
T9707 7598-7601 NN denotes PKC
T9708 7602-7605 CC denotes and
T9709 7606-7609 DT denotes the
T9710 7610-7623 NN denotes transcription
T9711 7624-7631 NN denotes factors
T9712 7632-7636 NN denotes AP-1
T9713 7637-7640 CC denotes and
T9714 7641-7646 NN denotes NF-κB
T9715 7648-7653 NN denotes Bcl10
T9716 7654-7660 NN denotes levels
T9717 7661-7665 VB denotes were
T9718 7666-7680 VB denotes down-regulated
T9719 7681-7690 VB denotes following
T9720 7691-7699 VB denotes extended
T9721 7700-7709 NN denotes treatment
T9722 7710-7712 IN denotes of
T9723 7713-7719 NN denotes Jurkat
T9724 7720-7727 NN denotes T-cells
T9725 7728-7732 IN denotes with
T9726 7733-7736 NN denotes PMA
T9727 7738-7740 IN denotes In
T9728 7741-7744 DT denotes the
T9729 7745-7752 NN denotes control
T9730 7753-7759 NN denotes groups
T9731 7759-7760 -COMMA- denotes ,
T9732 7761-7762 DT denotes a
T9733 7763-7767 NN denotes loss
T9734 7768-7770 IN denotes of
T9735 7771-7776 NN denotes Bcl10
T9736 7777-7785 VB denotes occurred
T9737 7786-7791 IN denotes after
T9738 7792-7793 CD denotes 6
T9739 7794-7795 NN denotes h
T9740 7795-7796 -COMMA- denotes ,
T9741 7797-7805 VB denotes followed
T9742 7806-7808 IN denotes by
T9743 7809-7811 DT denotes an
T9744 7812-7820 NN denotes increase
T9745 7821-7826 IN denotes after
T9746 7827-7829 CD denotes 24
T9747 7830-7831 NN denotes h
T9748 7831-7832 -COMMA- denotes ,
T9749 7833-7838 WDT denotes which
T9750 7839-7841 VB denotes is
T9751 7842-7844 IN denotes in
T9752 7845-7855 NN denotes accordance
T9753 7856-7860 IN denotes with
T9754 7861-7864 DT denotes the
T9755 7865-7873 VB denotes observed
T9756 7874-7879 NN denotes NF-κB
T9757 7880-7888 NN denotes activity
T9758 7889-7890 -LRB- denotes (
T9759 7890-7896 NN denotes figure
T9760 7897-7898 CD denotes 7
T9761 7898-7899 -RRB- denotes )
T9762 7901-7906 DT denotes These
T9763 7907-7914 NN denotes results
T9764 7915-7918 VB denotes are
T9765 7919-7928 VB denotes supported
T9766 7929-7931 IN denotes by
T9767 7932-7934 DT denotes an
T9768 7935-7942 JJ denotes earlier
T9769 7943-7948 NN denotes study
T9770 7949-7950 -LRB- denotes [
T9771 7950-7952 CD denotes 47
T9772 7952-7953 -RRB- denotes ]
T9773 7953-7954 -COMMA- denotes ,
T9774 7955-7968 VB denotes demonstrating
T9775 7969-7973 IN denotes that
T9776 7974-7983 JJ denotes prolonged
T9777 7984-7987 NN denotes PKC
T9778 7988-7998 NN denotes activation
T9779 7999-8001 IN denotes by
T9780 8002-8005 NN denotes PMA
T9781 8006-8011 VB denotes leads
T9782 8012-8014 TO denotes to
T9783 8015-8017 DT denotes an
T9784 8018-8028 NN denotes inhibition
T9785 8029-8031 IN denotes of
T9786 8032-8037 NN denotes Bcl10
T9787 8038-8041 CC denotes and
T9788 8042-8047 NN denotes NF-κB
T9789 8049-8051 PRP denotes It
T9790 8052-8055 VB denotes has
T9791 8056-8060 VB denotes been
T9792 8061-8066 VB denotes shown
T9793 8067-8071 IN denotes that
T9794 8072-8077 NN denotes NF-κB
T9795 8078-8080 VB denotes is
T9796 8081-8083 DT denotes an
T9797 8084-8093 JJ denotes important
T9798 8094-8107 NN denotes transcription
T9799 8108-8114 NN denotes factor
T9800 8115-8122 NN denotes complex
T9801 8123-8131 VB denotes involved
T9802 8132-8134 IN denotes in
T9803 8135-8141 RB denotes almost
T9804 8142-8147 DT denotes every
T9805 8148-8154 NN denotes aspect
T9806 8155-8157 IN denotes of
T9807 8158-8162 NN denotes cell
T9808 8163-8173 NN denotes regulation
T9809 8174-8183 VB denotes including
T9810 8184-8193 NN denotes apoptosis
T9811 8193-8194 -COMMA- denotes ,
T9812 8195-8210 NN denotes differentiation
T9813 8210-8211 -COMMA- denotes ,
T9814 8212-8225 NN denotes proliferation
T9815 8226-8229 CC denotes and
T9816 8230-8240 NN denotes initiation
T9817 8241-8243 IN denotes of
T9818 8244-8250 JJ denotes immune
T9819 8251-8260 NN denotes responses
T9820 8261-8262 -LRB- denotes [
T9821 8262-8267 CD denotes 51-53
T9822 8267-8268 -RRB- denotes ]
T9823 8270-8275 NN denotes NF-κB
T9824 8276-8278 VB denotes is
T9825 8279-8293 RB denotes constitutively
T9826 8294-8300 JJ denotes active
T9827 8301-8303 IN denotes in
T9828 8304-8308 JJ denotes many
T9829 8309-8314 JJ denotes human
T9830 8315-8327 NN denotes malignancies
T9831 8327-8328 -COMMA- denotes ,
T9832 8329-8334 WDT denotes which
T9833 8335-8340 VB denotes makes
T9834 8341-8343 PRP denotes it
T9835 8344-8346 DT denotes an
T9836 8347-8357 JJ denotes attractive
T9837 8358-8369 JJ denotes therapeutic
T9838 8370-8376 NN denotes target
T9839 8377-8378 -LRB- denotes [
T9840 8378-8380 CD denotes 54
T9841 8380-8381 -RRB- denotes ]
T9842 8383-8391 JJ denotes Elevated
T9843 8392-8397 NN denotes CXCL8
T9844 8398-8404 NN denotes levels
T9845 8405-8411 IN denotes during
T9846 8412-8419 JJ denotes chronic
T9847 8420-8432 NN denotes inflammation
T9848 8433-8439 VB denotes result
T9849 8440-8442 IN denotes in
T9850 8443-8445 DT denotes an
T9851 8446-8454 VB denotes enhanced
T9852 8455-8466 NN denotes recruitment
T9853 8467-8469 IN denotes of
T9854 8470-8476 JJ denotes immune
T9855 8477-8482 NN denotes cells
T9856 8483-8485 TO denotes to
T9857 8486-8489 DT denotes the
T9858 8490-8494 NN denotes site
T9859 8495-8497 IN denotes of
T9860 8498-8507 NN denotes infection
T9861 8507-8508 -COMMA- denotes ,
T9862 8509-8514 WDT denotes which
T9863 8515-8518 MD denotes may
T9864 8519-8523 VB denotes lead
T9865 8524-8526 TO denotes to
T9866 8527-8530 DT denotes the
T9867 8531-8542 NN denotes development
T9868 8543-8545 IN denotes of
T9869 8546-8556 JJ denotes autoimmune
T9870 8557-8565 NN denotes diseases
T9871 8566-8575 VB denotes following
T9872 8576-8585 NN denotes secretion
T9873 8586-8588 IN denotes of
T9874 8589-8605 JJ denotes pro-inflammatory
T9875 8606-8615 NN denotes cytokines
T9876 8617-8619 IN denotes In
T9877 8620-8623 NN denotes HIV
T9878 8624-8632 JJ denotes infected
T9879 8633-8640 NN denotes persons
T9880 8640-8641 -COMMA- denotes ,
T9881 8642-8647 NN denotes serum
T9882 8648-8653 NN denotes CXCL8
T9883 8654-8660 NN denotes levels
T9884 8661-8664 VB denotes are
T9885 8665-8673 VB denotes elevated
T9886 8674-8677 CC denotes and
T9887 8678-8682 DT denotes this
T9888 8683-8688 MD denotes could
T9889 8689-8696 VB denotes recruit
T9890 8697-8701 JJ denotes more
T9891 8702-8709 NN denotes T-cells
T9892 8710-8721 RB denotes potentially
T9893 8722-8729 VB denotes leading
T9894 8730-8732 TO denotes to
T9895 8733-8734 DT denotes a
T9896 8735-8739 RB denotes more
T9897 8740-8745 JJ denotes rapid
T9898 8746-8757 NN denotes progression
T9899 8758-8760 IN denotes of
T9900 8761-8764 DT denotes the
T9901 8765-8772 NN denotes disease
T9902 8773-8778 IN denotes since
T9903 8779-8784 EX denotes there
T9904 8785-8789 MD denotes will
T9905 8790-8792 VB denotes be
T9906 8793-8797 JJ denotes more
T9907 8798-8805 NN denotes T-cells
T9908 8806-8815 JJ denotes available
T9909 8816-8818 TO denotes to
T9910 8819-8825 VB denotes infect
R6880 T8442 T8443 arg1Of NF-κB,and
R6881 T8443 T8445 arg1Of and,are
R6882 T8444 T8443 arg2Of AP-1,and
R6883 T8445 T8460 arg1Of are,","
R6885 T8447 T8445 arg2Of regulators,are
R6886 T8447 T8446 arg1Of regulators,critical
R6887 T8447 T8448 arg1Of regulators,of
R6888 T8447 T8451 arg1Of regulators,","
R6890 T8450 T8448 arg2Of responses,of
R6891 T8450 T8449 arg1Of responses,inflammatory
R6893 T8452 T8453 arg1Of proliferation,and
R6894 T8453 T8451 arg2Of and,","
R6895 T8453 T8455 arg1Of and,of
R6896 T8454 T8453 arg2Of differentiation,and
R6898 T8456 T8455 arg2Of T-cells,of
R6899 T8456 T8457 arg1Of T-cells,[
R6901 T8458 T8457 arg2Of 28-30,[
R6902 T8459 T8457 arg3Of ],[
R6905 T8465 T8464 arg1Of transduction,signal
R6906 T8465 T8466 arg1Of transduction,and
R6908 T8466 T8463 arg1Of and,the
R6909 T8466 T8470 arg1Of and,is
R6910 T8466 T8473 arg2Of and,understood
R6911 T8469 T8466 arg2Of expression,and
R6912 T8469 T8467 arg1Of expression,subsequent
R6913 T8469 T8468 arg1Of expression,cytokine/chemokine
R6916 T8473 T8460 arg2Of understood,","
R6917 T8473 T8461 arg1Of understood,however
R6918 T8473 T8462 arg1Of understood,","
R6919 T8473 T8470 arg2Of understood,is
R6920 T8473 T8471 arg1Of understood,not
R6921 T8473 T8472 arg1Of understood,fully
R6922 T8475 T8474 arg1Of aim,The
R6923 T8475 T8476 arg1Of aim,of
R6924 T8475 T8480 arg1Of aim,was
R6925 T8479 T8476 arg2Of study,of
R6926 T8479 T8477 arg1Of study,the
R6927 T8479 T8478 arg1Of study,present
R6929 T8482 T8480 arg2Of investigate,was
R6930 T8482 T8481 arg1Of investigate,to
R6931 T8482 T8491 arg1Of investigate,in
R6932 T8483 T8484 arg1Of IL-6,and
R6934 T8485 T8484 arg2Of CXCL8,and
R6935 T8486 T8482 arg2Of regulation,investigate
R6936 T8486 T8483 arg1Of regulation,IL-6
R6937 T8486 T8485 arg1Of regulation,CXCL8
R6938 T8486 T8487 arg1Of regulation,by
R6940 T8488 T8489 arg1Of NF-κB,and
R6941 T8489 T8487 arg2Of and,by
R6942 T8490 T8489 arg2Of AP-1,and
R6945 T8493 T8491 arg2Of T-cells,in
R6946 T8493 T8492 arg1Of T-cells,Jurkat
R6947 T8495 T8494 arg1Of results,Our
R6948 T8495 T8496 arg1Of results,demonstrated
R6952 T8498 T8499 arg1Of PMA,induced
R6954 T8499 T8496 arg2Of induced,demonstrated
R6955 T8499 T8497 arg1Of induced,that
R6956 T8499 T8502 arg1Of induced,","
R6957 T8499 T8503 modOf induced,indicating
R6958 T8501 T8499 arg2Of activation,induced
R6959 T8501 T8500 arg1Of activation,AP-1
R6962 T8506 T8503 arg2Of activation,indicating
R6963 T8506 T8504 arg1Of activation,a
R6964 T8506 T8505 arg1Of activation,specific
R6965 T8506 T8507 arg1Of activation,of
R6968 T8510 T8507 arg2Of pathway,of
R6969 T8510 T8508 arg1Of pathway,the
R6970 T8510 T8509 arg1Of pathway,MAPK
R6972 T8513 T8514 arg1Of we,demonstrated
R6975 T8514 T8511 arg1Of demonstrated,Furthermore
R6976 T8514 T8512 arg1Of demonstrated,","
R6978 T8519 T8516 arg1Of activation,PMA
R6979 T8519 T8517 arg1Of activation,dependent
R6980 T8519 T8518 arg1Of activation,AP-1
R6981 T8519 T8520 arg1Of activation,in
R6982 T8519 T8522 arg1Of activation,was
R6983 T8519 T8523 arg2Of activation,delayed
R6984 T8519 T8530 arg2Of activation,increased
R6985 T8521 T8520 arg2Of T-cells,in
R6987 T8523 T8524 arg1Of delayed,(
R6988 T8523 T8529 arg1Of delayed,and
R6990 T8526 T8525 arg1Of 2,>
R6992 T8527 T8524 arg2Of h,(
R6993 T8527 T8526 arg1Of h,2
R6994 T8528 T8524 arg3Of ),(
R6995 T8529 T8514 arg2Of and,demonstrated
R6996 T8529 T8515 arg1Of and,that
R6997 T8529 T8522 arg2Of and,was
R6998 T8530 T8529 arg2Of increased,and
R6999 T8530 T8531 arg1Of increased,following
R7001 T8533 T8531 arg2Of treatment,following
R7002 T8533 T8532 arg1Of treatment,long-term
R7003 T8534 T8535 arg1Of MAPK,is
R7005 T8536 T8535 arg2Of one,is
R7006 T8536 T8537 arg1Of one,of
R7009 T8541 T8537 arg2Of pathways,of
R7010 T8541 T8538 arg1Of pathways,the
R7011 T8541 T8539 arg1Of pathways,main
R7012 T8541 T8540 arg1Of pathways,signalling
R7013 T8541 T8542 arg1Of pathways,in
R7014 T8543 T8542 arg2Of T-cells,in
R7015 T8543 T8544 arg1Of T-cells,that
R7016 T8543 T8545 arg1Of T-cells,regulate
R7018 T8546 T8547 arg1Of cell-,and
R7020 T8547 T8545 arg2Of and,regulate
R7021 T8549 T8547 arg2Of activation,and
R7022 T8549 T8548 arg1Of activation,transcriptional
R7023 T8549 T8550 arg1Of activation,[
R7025 T8551 T8550 arg2Of "31,32",[
R7026 T8552 T8550 arg3Of ],[
R7027 T8554 T8553 arg1Of studies,Several
R7028 T8554 T8555 arg1Of studies,[
R7029 T8554 T8558 arg1Of studies,have
R7030 T8554 T8559 arg1Of studies,indicated
R7031 T8556 T8555 arg2Of "20,33,34",[
R7033 T8557 T8555 arg3Of ],[
R7034 T8559 T8558 arg2Of indicated,have
R7035 T8559 T8564 arg1Of indicated,in
R7037 T8561 T8559 arg2Of importance,indicated
R7038 T8561 T8560 arg1Of importance,the
R7039 T8561 T8562 arg1Of importance,of
R7041 T8563 T8562 arg2Of AP-1,of
R7043 T8566 T8565 arg1Of activation,T-cell
R7044 T8566 T8567 arg1Of activation,and
R7045 T8567 T8564 arg2Of and,in
R7047 T8569 T8567 arg2Of induction,and
R7048 T8569 T8568 arg1Of induction,the
R7049 T8569 T8570 arg1Of induction,of
R7051 T8572 T8570 arg2Of responses,of
R7052 T8572 T8571 arg1Of responses,inflammatory
R7053 T8572 T8573 arg1Of responses,[
R7054 T8572 T8576 arg1Of responses,","
R7055 T8572 T8577 arg1Of responses,including
R7057 T8574 T8573 arg2Of 35,[
R7058 T8575 T8573 arg3Of ],[
R7061 T8580 T8577 arg2Of release,including
R7062 T8580 T8578 arg1Of release,pro-inflammatory
R7063 T8580 T8579 arg1Of release,cytokine
R7065 T8582 T8581 arg2Of contrast,In
R7066 T8582 T8583 arg1Of contrast,to
R7068 T8584 T8583 arg2Of AP-1,to
R7070 T8587 T8586 arg1Of activity,NF-κB
R7071 T8587 T8589 arg1Of activity,increased
R7073 T8589 T8581 arg1Of increased,In
R7074 T8589 T8585 arg1Of increased,","
R7075 T8589 T8588 arg1Of increased,rapidly
R7076 T8589 T8590 arg1Of increased,(
R7077 T8589 T8594 arg1Of increased,during
R7078 T8592 T8590 arg2Of min,(
R7079 T8592 T8591 arg1Of min,1
R7080 T8593 T8590 arg3Of ),(
R7082 T8596 T8594 arg2Of exposure,during
R7083 T8596 T8595 arg1Of exposure,PMA
R7084 T8596 T8597 arg2Of exposure,followed
R7086 T8600 T8597 arg1Of down-regulation,followed
R7087 T8600 T8598 arg2Of down-regulation,by
R7088 T8600 T8599 arg1Of down-regulation,a
R7089 T8600 T8601 arg1Of down-regulation,to
R7090 T8600 T8605 arg1Of down-regulation,at
R7092 T8604 T8601 arg2Of levels,to
R7093 T8604 T8602 arg1Of levels,the
R7094 T8604 T8603 arg1Of levels,lowest
R7096 T8607 T8605 arg2Of h,at
R7097 T8607 T8606 arg1Of h,6
R7098 T8611 T8610 arg2Of line,in
R7099 T8608 T8609 arg1Of This,is
R7100 T8608 T8610 arg1Of This,in
R7101 T8609 T8633 arg1Of is,but
R7102 T8610 T8609 arg2Of in,is
R7103 T8611 T8612 arg1Of line,with
R7104 T8611 T8619 arg1Of line,who
R7105 T8611 T8620 arg1Of line,demonstrated
R7106 T8613 T8614 arg1Of Park,and
R7107 T8614 T8612 arg2Of and,with
R7108 T8615 T8614 arg2Of colleagues,and
R7109 T8615 T8616 arg1Of colleagues,[
R7110 T8617 T8616 arg2Of 36,[
R7111 T8712 T8708 arg2Of stimulation,following
R7112 T8712 T8709 arg1Of stimulation,HK
R7113 T8712 T8710 arg1Of stimulation,E.
R7114 T8712 T8711 arg1Of stimulation,coli
R7115 T8714 T8713 arg2Of be,may
R7116 T8618 T8616 arg3Of ],[
R7117 T8716 T8714 arg2Of to,be
R7118 T8716 T8715 arg1Of to,due
R7119 T8620 T8627 arg1Of demonstrated,following
R7120 T8623 T8620 arg2Of increase,demonstrated
R7121 T8721 T8716 arg2Of calmodulin,to
R7122 T8721 T8717 arg1Of calmodulin,the
R7123 T8721 T8718 arg1Of calmodulin,Ca2+
R7124 T8721 T8719 arg1Of calmodulin,binding
R7125 T8721 T8720 arg1Of calmodulin,protein
R7126 T8721 T8722 arg1Of calmodulin,(
R7127 T8721 T8725 arg1Of calmodulin,","
R7128 T8721 T8726 arg1Of calmodulin,which
R7129 T8721 T8727 arg1Of calmodulin,has
R7130 T8721 T8728 arg1Of calmodulin,been
R7131 T8721 T8729 arg2Of calmodulin,shown
R7132 T8721 T8732 arg1Of calmodulin,regulate
R7133 T8723 T8722 arg2Of CaM,(
R7134 T8724 T8722 arg3Of ),(
R7135 T8623 T8621 arg1Of increase,a
R7136 T8623 T8622 arg1Of increase,rapid
R7137 T8623 T8624 arg1Of increase,in
R7138 T8729 T8727 arg2Of shown,has
R7139 T8729 T8728 arg2Of shown,been
R7140 T8626 T8624 arg2Of activity,in
R7141 T8732 T8729 arg3Of regulate,shown
R7142 T8732 T8730 arg1Of regulate,to
R7143 T8732 T8731 arg1Of regulate,negatively
R7144 T8732 T8734 arg1Of regulate,when
R7145 T8733 T8732 arg2Of c-Rel,regulate
R7146 T8735 T8734 arg2Of activated,when
R7147 T8735 T8736 arg1Of activated,[
R7148 T8737 T8736 arg2Of 38,[
R7149 T8626 T8625 arg1Of activity,NF-κB
R7150 T8738 T8736 arg3Of ],[
R7151 T8629 T8627 arg2Of stimulation,following
R7152 T8740 T8739 arg1Of regulation,The
R7153 T8740 T8741 arg1Of regulation,of
R7154 T8740 T8745 arg2Of regulation,observed
R7155 T8740 T8750 arg1Of regulation,was
R7156 T8740 T8751 arg1Of regulation,in
R7157 T8742 T8743 arg1Of NF-κB,and
R7158 T8743 T8741 arg2Of and,of
R7159 T8744 T8743 arg2Of AP-1,and
R7160 T8629 T8628 arg1Of stimulation,short-term
R7161 T8745 T8746 arg1Of observed,in
R7162 T8629 T8630 arg1Of stimulation,with
R7163 T8631 T8630 arg2Of PMA,with
R7164 T8749 T8746 arg2Of study,in
R7165 T8749 T8747 arg1Of study,the
R7166 T8749 T8748 arg1Of study,present
R7167 T8751 T8750 arg2Of in,was
R7168 T8633 T8632 arg1Of but,","
R7169 T8752 T8751 arg2Of agreement,in
R7170 T8752 T8753 arg1Of agreement,with
R7171 T8755 T8753 arg2Of studies,with
R7172 T8755 T8754 arg1Of studies,earlier
R7173 T8635 T8634 arg2Of challenge,prolonged
R7174 T8756 T8757 arg1Of T-cells,produce
R7175 T8635 T8636 arg1Of challenge,resulted
R7176 T8760 T8757 arg2Of range,produce
R7177 T8760 T8758 arg1Of range,a
R7178 T8760 T8759 arg1Of range,broad
R7179 T8760 T8761 arg1Of range,of
R7180 T8762 T8763 arg1Of pro-,and
R7181 T8636 T8633 arg2Of resulted,but
R7182 T8764 T8763 arg2Of anti-inflammatory,and
R7183 T8765 T8761 arg2Of cytokines,of
R7184 T8765 T8762 arg1Of cytokines,pro-
R7185 T8765 T8764 arg1Of cytokines,anti-inflammatory
R7186 T8765 T8766 arg1Of cytokines,","
R7187 T8765 T8767 arg1Of cytokines,including
R7188 T8636 T8637 arg1Of resulted,in
R7189 T8768 T8769 arg1Of IL-2,","
R7190 T8640 T8637 arg2Of inhibition,in
R7191 T8769 T8771 arg1Of ",",","
R7192 T8770 T8769 arg2Of IL-6,","
R7193 T8771 T8773 arg1Of ",",","
R7194 T8772 T8771 arg2Of CXCL8,","
R7195 T8773 T8775 arg1Of ",",and
R7196 T8774 T8773 arg2Of TNF,","
R7197 T8640 T8638 arg1Of inhibition,a
R7198 T8775 T8767 arg2Of and,including
R7199 T8775 T8777 arg1Of and,","
R7200 T8775 T8778 arg1Of and,in
R7201 T8776 T8775 arg2Of IL-10,and
R7202 T8640 T8639 arg1Of inhibition,persistent
R7203 T8640 T8641 arg1Of inhibition,of
R7204 T8642 T8641 arg2Of NF-κB,of
R7205 T8779 T8778 arg2Of response,in
R7206 T8779 T8780 arg1Of response,to
R7207 T8781 T8782 arg1Of infections,or
R7208 T8782 T8780 arg2Of or,to
R7209 T8643 T8644 arg1Of They,showed
R7210 T8785 T8782 arg2Of factors,or
R7211 T8785 T8783 arg1Of factors,other
R7212 T8785 T8784 arg1Of factors,stress
R7213 T8785 T8786 arg1Of factors,[
R7214 T8647 T8646 arg1Of inhibition,the
R7215 T8787 T8786 arg2Of 39,[
R7216 T8788 T8786 arg3Of ],[
R7217 T8790 T8789 arg1Of assessment,The
R7218 T8790 T8791 arg1Of assessment,of
R7219 T8790 T8800 arg1Of assessment,revealed
R7220 T8647 T8648 arg1Of inhibition,of
R7221 T8647 T8650 arg1Of inhibition,was
R7222 T8647 T8651 arg1Of inhibition,due
R7223 T8647 T8660 arg1Of inhibition,γ
R7224 T8649 T8648 arg2Of NF-κB,of
R7225 T8795 T8791 arg2Of responses,of
R7226 T8795 T8792 arg1Of responses,Jurkat
R7227 T8795 T8793 arg1Of responses,T-cell
R7228 T8795 T8794 arg1Of responses,inflammatory
R7229 T8795 T8796 arg1Of responses,(
R7230 T8797 T8796 arg2Of Table,(
R7231 T8797 T8798 arg1Of Table,1
R7232 T8799 T8796 arg3Of ),(
R7233 T8800 T8805 arg1Of revealed,upon
R7234 T8650 T8659 arg1Of was,and
R7235 T8804 T8800 arg2Of expression,revealed
R7236 T8804 T8801 arg1Of expression,an
R7237 T8804 T8802 arg2Of expression,enhanced
R7238 T8804 T8803 arg1Of expression,IL-2
R7239 T8651 T8650 arg2Of due,was
R7240 T8651 T8652 arg1Of due,to
R7241 T8654 T8652 arg2Of degradation,to
R7242 T8806 T8805 arg2Of exposure,upon
R7243 T8806 T8807 arg1Of exposure,to
R7244 T8654 T8653 arg1Of degradation,PKC-dependent
R7245 T8808 T8809 arg1Of PMA,or
R7246 T8654 T8655 arg1Of degradation,of
R7247 T8809 T8807 arg2Of or,to
R7248 T8809 T8814 arg1Of or,to
R7249 T8658 T8655 arg2Of β,of
R7250 T8812 T8809 arg2Of coli,or
R7251 T8812 T8810 arg1Of coli,HK
R7252 T8812 T8811 arg1Of coli,E.
R7253 T8814 T8813 arg1Of to,due
R7254 T8816 T8814 arg2Of activation,to
R7255 T8816 T8815 arg1Of activation,PKC
R7256 T8816 T8817 arg1Of activation,[
R7257 T8658 T8656 arg1Of β,IκB
R7258 T8818 T8817 arg2Of 40,[
R7259 T8658 T8657 arg1Of β,kinase
R7260 T8819 T8817 arg3Of ],[
R7261 T8659 T8644 arg2Of and,showed
R7262 T8821 T8820 arg2Of addition,In
R7263 T8821 T8822 arg1Of addition,to
R7264 T8659 T8645 arg1Of and,that
R7265 T8660 T8659 arg2Of γ,and
R7266 T8826 T8822 arg2Of NF-κB,to
R7267 T8826 T8823 arg1Of NF-κB,the
R7268 T8826 T8824 arg1Of NF-κB,transcription
R7269 T8826 T8825 arg1Of NF-κB,factor
R7270 T8660 T8661 arg1Of γ,in
R7271 T8662 T8661 arg2Of response,in
R7272 T8830 T8828 arg1Of sites,AP-1
R7273 T8830 T8829 arg1Of sites,binding
R7274 T8830 T8831 arg1Of sites,have
R7275 T8830 T8832 arg1Of sites,been
R7276 T8830 T8833 arg2Of sites,identified
R7277 T8833 T8820 arg1Of identified,In
R7278 T8833 T8827 arg1Of identified,","
R7279 T8833 T8831 arg2Of identified,have
R7280 T8833 T8832 arg2Of identified,been
R7281 T8833 T8834 arg1Of identified,in
R7282 T8833 T8839 arg1Of identified,","
R7283 T8662 T8663 arg1Of response,to
R7284 T8838 T8834 arg2Of region,in
R7285 T8838 T8835 arg1Of region,the
R7286 T8838 T8836 arg1Of region,IL-6
R7287 T8838 T8837 arg1Of region,promoter
R7288 T8664 T8663 arg2Of PMA,to
R7289 T8840 T8833 arg3Of indicating,identified
R7290 T8842 T8840 arg2Of regulation,indicating
R7291 T8842 T8841 arg1Of regulation,multiple
R7292 T8842 T8843 arg1Of regulation,[
R7293 T8844 T8843 arg2Of 22,[
R7294 T8671 T8667 arg1Of exposure,the
R7295 T8845 T8843 arg3Of ],[
R7296 T8846 T8847 arg1Of AP-1,and
R7297 T8847 T8849 arg1Of and,have
R7298 T8847 T8851 arg1Of and,been
R7299 T8847 T8852 arg2Of and,demonstrated
R7300 T8847 T8854 arg1Of and,regulate
R7301 T8848 T8847 arg2Of NF-κB,and
R7302 T8852 T8849 arg2Of demonstrated,have
R7303 T8852 T8850 arg1Of demonstrated,also
R7304 T8852 T8851 arg2Of demonstrated,been
R7305 T8854 T8852 arg3Of regulate,demonstrated
R7306 T8854 T8853 arg1Of regulate,to
R7307 T8856 T8854 arg2Of expression,regulate
R7308 T8856 T8855 arg1Of expression,CXCL8
R7309 T8856 T8857 arg1Of expression,during
R7310 T8856 T8862 arg1Of expression,in
R7311 T8858 T8857 arg2Of induction,during
R7312 T8858 T8859 arg1Of induction,of
R7313 T8671 T8668 arg1Of exposure,HK
R7314 T8671 T8669 arg1Of exposure,E.
R7315 T8671 T8670 arg1Of exposure,coli
R7316 T8861 T8859 arg2Of responses,of
R7317 T8861 T8860 arg1Of responses,inflammatory
R7318 T8671 T8672 arg1Of exposure,induced
R7319 T8863 T8862 arg2Of T-cells,in
R7320 T8863 T8864 arg1Of T-cells,[
R7321 T8671 T8676 arg1Of exposure,affecting
R7322 T8865 T8864 arg2Of 12,[
R7323 T8672 T8665 arg1Of induced,Interestingly
R7324 T8866 T8864 arg3Of ],[
R7325 T8672 T8666 arg1Of induced,","
R7326 T8672 T8675 arg1Of induced,without
R7327 T8674 T8672 arg2Of activation,induced
R7328 T8869 T8870 arg1Of IL-6,and
R7329 T8870 T8873 arg1Of and,is
R7330 T8870 T8874 arg2Of and,associated
R7331 T8872 T8870 arg2Of gene-expression,and
R7332 T8872 T8871 arg1Of gene-expression,CXCL8
R7333 T8674 T8673 arg1Of activation,NF-κB
R7334 T8676 T8675 arg2Of affecting,without
R7335 T8874 T8867 arg1Of associated,Furthermore
R7336 T8874 T8868 arg1Of associated,","
R7337 T8874 T8873 arg2Of associated,is
R7338 T8874 T8875 arg1Of associated,with
R7339 T8678 T8676 arg2Of activity,affecting
R7340 T8879 T8875 arg2Of response,with
R7341 T8879 T8876 arg1Of response,an
R7342 T8879 T8877 arg1Of response,early
R7343 T8879 T8878 arg1Of response,immune
R7344 T8879 T8880 arg1Of response,in
R7345 T8879 T8883 arg1Of response,[
R7346 T8882 T8880 arg2Of T-cells,in
R7347 T8882 T8881 arg1Of T-cells,Jurkat
R7348 T8678 T8677 arg1Of activity,AP-1
R7349 T8884 T8883 arg2Of 41,[
R7350 T8679 T8680 arg1Of Wang,and
R7351 T8885 T8883 arg3Of ],[
R7352 T8680 T8685 arg1Of and,reported
R7353 T8889 T8886 arg2Of study,In
R7354 T8889 T8887 arg1Of study,the
R7355 T8889 T8888 arg1Of study,present
R7356 T8680 T8691 arg1Of and,obtaining
R7357 T8681 T8680 arg2Of colleagues,and
R7358 T8892 T8893 arg1Of PMA,and
R7359 T8893 T8891 arg1Of and,both
R7360 T8893 T8897 arg1Of and,resulted
R7361 T8895 T8893 arg2Of E.,and
R7362 T8895 T8894 arg1Of E.,HK
R7363 T8895 T8896 arg1Of E.,coli
R7364 T8681 T8682 arg1Of colleagues,[
R7365 T8897 T8886 arg1Of resulted,In
R7366 T8897 T8890 arg1Of resulted,","
R7367 T8897 T8898 arg1Of resulted,in
R7368 T8897 T8903 arg1Of resulted,while
R7369 T8683 T8682 arg2Of 37,[
R7370 T8900 T8898 arg2Of increases,in
R7371 T8900 T8899 arg1Of increases,comparable
R7372 T8900 T8901 arg1Of increases,in
R7373 T8684 T8682 arg3Of ],[
R7374 T8685 T8690 arg1Of reported,by
R7375 T8688 T8687 arg1Of inflammatory,elevated
R7376 T8902 T8901 arg2Of IL-6,in
R7377 T8904 T8905 arg1Of PMA,was
R7378 T8904 T8907 arg1Of PMA,potent
R7379 T8905 T8903 arg2Of was,while
R7380 T8907 T8905 arg2Of potent,was
R7381 T8907 T8906 arg1Of potent,more
R7382 T8907 T8908 arg1Of potent,at
R7383 T8909 T8908 arg2Of activating,at
R7384 T8689 T8685 arg2Of response,reported
R7385 T8911 T8909 arg2Of release,activating
R7386 T8911 T8910 arg1Of release,CXCL8
R7387 T8912 T8913 arg1Of PMA,and
R7388 T8689 T8686 arg1Of response,an
R7389 T8913 T8919 arg1Of and,induced
R7390 T8689 T8688 arg1Of response,inflammatory
R7391 T8691 T8690 arg2Of obtaining,by
R7392 T8917 T8913 arg2Of treatment,and
R7393 T8917 T8914 arg1Of treatment,HK
R7394 T8917 T8915 arg1Of treatment,E.
R7395 T8917 T8916 arg1Of treatment,coli
R7396 T8919 T8918 arg1Of induced,also
R7397 T8691 T8695 arg1Of obtaining,following
R7398 T8921 T8919 arg2Of expression,induced
R7399 T8921 T8920 arg1Of expression,TNF
R7400 T8692 T8691 arg2Of expression,obtaining
R7401 T8922 T8923 arg1Of TNF,is
R7402 T8923 T8935 arg1Of is,and
R7403 T8924 T8923 arg2Of one,is
R7404 T8924 T8925 arg1Of one,of
R7405 T8692 T8693 arg1Of expression,of
R7406 T8694 T8693 arg2Of IL-6,of
R7407 T8928 T8925 arg2Of cytokines,of
R7408 T8928 T8926 arg1Of cytokines,the
R7409 T8928 T8927 arg1Of cytokines,first
R7410 T8928 T8929 arg2Of cytokines,induced
R7411 T8697 T8695 arg2Of exposure,following
R7412 T8931 T8929 arg1Of T-cells,induced
R7413 T8931 T8930 arg2Of T-cells,by
R7414 T8931 T8932 arg1Of T-cells,[
R7415 T8933 T8932 arg2Of 42,[
R7416 T8934 T8932 arg3Of ],[
R7417 T8697 T8696 arg1Of exposure,the
R7418 T8937 T8936 arg1Of expression,its
R7419 T8937 T8938 arg1Of expression,is
R7420 T8937 T8939 arg2Of expression,regulated
R7421 T8697 T8698 arg1Of exposure,of
R7422 T8939 T8935 arg2Of regulated,and
R7423 T8939 T8938 arg2Of regulated,is
R7424 T8697 T8700 arg1Of exposure,to
R7425 T8699 T8698 arg2Of T-cells,of
R7426 T8939 T8946 arg1Of regulated,[
R7427 T8701 T8700 arg2Of peptidoglycan,to
R7428 T8941 T8942 arg1Of calcineurin,","
R7429 T8942 T8944 arg1Of ",",and
R7430 T8943 T8942 arg2Of NFAT,","
R7431 T8944 T8939 arg1Of and,regulated
R7432 T8944 T8940 arg2Of and,by
R7433 T8945 T8944 arg2Of ATF-2/Jun,and
R7434 T8947 T8946 arg2Of 20,[
R7435 T8948 T8946 arg3Of ],[
R7436 T8702 T8703 arg1Of Reduction,in
R7437 T8702 T8705 arg1Of Reduction,by
R7438 T8702 T8708 arg1Of Reduction,following
R7439 T8953 T8951 arg1Of T-cells,PMA-stimulated
R7440 T8702 T8713 arg1Of Reduction,may
R7441 T8953 T8952 arg1Of T-cells,Jurkat
R7442 T8953 T8954 arg1Of T-cells,showed
R7443 T8954 T8949 arg1Of showed,However
R7444 T8954 T8950 arg1Of showed,","
R7445 T8702 T8714 arg1Of Reduction,be
R7446 T8702 T8716 arg1Of Reduction,to
R7447 T8956 T8954 arg2Of difference,showed
R7448 T8956 T8955 arg1Of difference,no
R7449 T8956 T8957 arg1Of difference,in
R7450 T8704 T8703 arg2Of NF-κB,in
R7451 T8959 T8957 arg2Of expression,in
R7452 T8959 T8958 arg1Of expression,IL-10
R7453 T8959 T8960 arg1Of expression,indicating
R7454 T8707 T8705 arg2Of ionophore,by
R7455 T8964 T8960 arg2Of response,indicating
R7456 T8964 T8961 arg1Of response,an
R7457 T8964 T8962 arg2Of response,induced
R7458 T8964 T8963 arg1Of response,inflammatory
R7459 T8707 T8706 arg1Of ionophore,calcium
R7460 T8999 T9001 arg1Of ",",and
R7461 T8968 T8965 arg1Of treatment,HK
R7462 T8968 T8966 arg1Of treatment,E.
R7463 T8968 T8967 arg1Of treatment,coli
R7464 T8968 T8969 arg1Of treatment,resulted
R7465 T8969 T8970 arg1Of resulted,in
R7466 T8973 T8970 arg2Of reduction,in
R7467 T8973 T8971 arg1Of reduction,a
R7468 T8973 T8972 arg1Of reduction,significant
R7469 T8973 T8974 arg1Of reduction,of
R7470 T9000 T8999 arg2Of IL-5,","
R7471 T8976 T8974 arg2Of expression,of
R7472 T8976 T8975 arg1Of expression,IL-10
R7473 T9001 T8997 arg2Of and,as
R7474 T8980 T8977 arg1Of IL-10,The
R7475 T8980 T8978 arg1Of IL-10,anti-inflammatory
R7476 T8980 T8979 arg1Of IL-10,cytokine
R7477 T8980 T8981 arg1Of IL-10,is
R7478 T8980 T8982 arg2Of IL-10,known
R7479 T8980 T8984 arg1Of IL-10,inhibit
R7480 T8980 T9007 arg1Of IL-10,regulate
R7481 T8980 T9011 arg1Of IL-10,inducing
R7482 T9001 T9003 arg1Of and,[
R7483 T9002 T9001 arg2Of INF-γ,and
R7484 T8982 T8981 arg2Of known,is
R7485 T8984 T9006 arg1Of inhibit,and
R7486 T9004 T9003 arg2Of "39,43",[
R7487 T8986 T8985 arg1Of activation,T-cell
R7488 T8986 T8987 arg1Of activation,","
R7489 T8987 T8989 arg1Of ",",and
R7490 T8988 T8987 arg2Of proliferation,","
R7491 T9005 T9003 arg3Of ],[
R7492 T8989 T8984 arg2Of and,inhibit
R7493 T8991 T8989 arg2Of expression,and
R7494 T8991 T8990 arg1Of expression,the
R7495 T8991 T8992 arg1Of expression,of
R7496 T9006 T8982 arg3Of and,known
R7497 T8994 T8992 arg2Of cytokines,of
R7498 T8994 T8993 arg1Of cytokines,pro-inflammatory
R7499 T8994 T8995 arg1Of cytokines,","
R7500 T8994 T8997 arg1Of cytokines,as
R7501 T9006 T8983 arg1Of and,to
R7502 T9007 T9006 arg2Of regulate,and
R7503 T8997 T8996 arg1Of as,such
R7504 T8998 T8999 arg1Of IL-2,","
R7505 T9007 T9010 arg1Of regulate,by
R7506 T9009 T9007 arg2Of responses,regulate
R7507 T9009 T9008 arg1Of responses,inflammatory
R7508 T9011 T9010 arg2Of inducing,by
R7509 T9096 T9097 arg1Of PKC,has
R7510 T9096 T9098 arg1Of PKC,been
R7511 T9096 T9099 arg2Of PKC,shown
R7512 T9096 T9101 arg1Of PKC,be
R7513 T9096 T9102 arg2Of PKC,associated
R7514 T9011 T9014 arg1Of inducing,[
R7515 T9099 T9097 arg2Of shown,has
R7516 T9099 T9098 arg2Of shown,been
R7517 T9013 T9011 arg2Of anergy,inducing
R7518 T9102 T9099 arg3Of associated,shown
R7519 T9102 T9100 arg1Of associated,to
R7520 T9102 T9101 arg2Of associated,be
R7521 T9102 T9103 arg1Of associated,with
R7522 T9102 T9111 arg1Of associated,with
R7523 T9102 T9118 arg1Of associated,[
R7524 T9103 T9109 arg1Of with,but
R7525 T9013 T9012 arg1Of anergy,T-cell
R7526 T9105 T9103 arg2Of activation,with
R7527 T9105 T9104 arg1Of activation,the
R7528 T9105 T9106 arg1Of activation,of
R7529 T9107 T9106 arg2Of AP-1,of
R7530 T9015 T9014 arg2Of 44,[
R7531 T9109 T9108 arg1Of but,","
R7532 T9111 T9109 arg2Of with,but
R7533 T9111 T9110 arg1Of with,not
R7534 T9113 T9111 arg2Of activation,with
R7535 T9113 T9112 arg1Of activation,NF-κB
R7536 T9113 T9114 arg1Of activation,of
R7537 T9016 T9014 arg3Of ],[
R7538 T9020 T9017 arg1Of analysis,The
R7539 T9117 T9114 arg2Of promoter,of
R7540 T9117 T9115 arg1Of promoter,the
R7541 T9117 T9116 arg1Of promoter,IL-2
R7542 T9119 T9118 arg2Of 45,[
R7543 T9120 T9118 arg3Of ],[
R7544 T9121 T9122 arg1Of Mutation,of
R7545 T9121 T9126 arg1Of Mutation,did
R7546 T9121 T9128 arg1Of Mutation,affect
R7547 T9020 T9018 arg1Of analysis,time
R7548 T9125 T9122 arg2Of site,of
R7549 T9125 T9123 arg1Of site,the
R7550 T9125 T9124 arg1Of site,NF-κB
R7551 T9020 T9019 arg1Of analysis,course
R7552 T9128 T9126 arg2Of affect,did
R7553 T9128 T9127 arg1Of affect,not
R7554 T9128 T9132 arg1Of affect,whereas
R7555 T9020 T9021 arg1Of analysis,of
R7556 T9020 T9024 arg1Of analysis,showed
R7557 T9130 T9128 arg2Of expression,affect
R7558 T9130 T9129 arg1Of expression,IL-2
R7559 T9023 T9021 arg2Of expression,of
R7560 T9132 T9131 arg1Of whereas,","
R7561 T9133 T9134 arg1Of mutation,of
R7562 T9133 T9142 arg1Of mutation,revoked
R7563 T9137 T9136 arg1Of site,AP-1
R7564 T9137 T9138 arg1Of site,or
R7565 T9023 T9022 arg1Of expression,cytokine
R7566 T9138 T9134 arg2Of or,of
R7567 T9138 T9135 arg1Of or,the
R7568 T9026 T9024 arg2Of correlation,showed
R7569 T9140 T9138 arg2Of depletion,or
R7570 T9140 T9139 arg1Of depletion,PKC
R7571 T9142 T9132 arg2Of revoked,whereas
R7572 T9142 T9141 arg1Of revoked,almost
R7573 T9144 T9142 arg2Of release,revoked
R7574 T9144 T9143 arg1Of release,IL-2
R7575 T9026 T9025 arg1Of correlation,a
R7576 T9146 T9145 arg1Of observations,These
R7577 T9146 T9147 arg1Of observations,indicate
R7578 T9026 T9027 arg1Of correlation,between
R7579 T9026 T9033 arg1Of correlation,where
R7580 T9151 T9149 arg1Of pathway,the
R7581 T9151 T9150 arg1Of pathway,MAPK
R7582 T9151 T9152 arg1Of pathway,and
R7583 T9152 T9157 arg1Of and,play
R7584 T9028 T9029 arg1Of AP-1,and
R7585 T9156 T9152 arg2Of AP-1,and
R7586 T9156 T9153 arg1Of AP-1,the
R7587 T9156 T9154 arg1Of AP-1,transcription
R7588 T9156 T9155 arg1Of AP-1,factor
R7589 T9157 T9147 arg2Of play,indicate
R7590 T9157 T9148 arg1Of play,that
R7591 T9157 T9161 arg1Of play,in
R7592 T9029 T9027 arg2Of and,between
R7593 T9157 T9170 arg1Of play,[
R7594 T9032 T9029 arg2Of CXCL8,and
R7595 T9160 T9157 arg2Of role,play
R7596 T9160 T9158 arg1Of role,an
R7597 T9160 T9159 arg1Of role,important
R7598 T9163 T9161 arg2Of induction,in
R7599 T9163 T9162 arg1Of induction,the
R7600 T9163 T9164 arg1Of induction,of
R7601 T9163 T9167 arg1Of induction,in
R7602 T9032 T9030 arg1Of CXCL8,the
R7603 T9032 T9031 arg1Of CXCL8,chemokine
R7604 T9166 T9164 arg2Of responses,of
R7605 T9166 T9165 arg1Of responses,inflammatory
R7606 T9035 T9034 arg1Of expression,CXCL8
R7607 T9169 T9167 arg2Of T-cells,in
R7608 T9169 T9168 arg1Of T-cells,Jurkat
R7609 T9171 T9170 arg2Of "12,20,22",[
R7610 T9172 T9170 arg3Of ],[
R7611 T9035 T9036 arg1Of expression,was
R7612 T9035 T9038 arg2Of expression,elevated
R7613 T9038 T9033 arg2Of elevated,where
R7614 T9175 T9173 arg1Of results,The
R7615 T9175 T9174 arg2Of results,obtained
R7616 T9175 T9176 arg1Of results,signify
R7617 T9178 T9179 arg1Of CXCL8,was
R7618 T9178 T9181 arg2Of CXCL8,regulated
R7619 T9038 T9036 arg2Of elevated,was
R7620 T9181 T9176 arg2Of regulated,signify
R7621 T9181 T9177 arg1Of regulated,that
R7622 T9181 T9179 arg2Of regulated,was
R7623 T9181 T9180 arg1Of regulated,primarily
R7624 T9181 T9182 arg1Of regulated,through
R7625 T9038 T9037 arg1Of elevated,significantly
R7626 T9038 T9039 arg1Of elevated,already
R7627 T9038 T9040 arg1Of elevated,at
R7628 T9185 T9182 arg2Of pathway,through
R7629 T9185 T9183 arg1Of pathway,the
R7630 T9185 T9184 arg1Of pathway,MAPK
R7631 T9038 T9043 arg1Of elevated,after
R7632 T9189 T9186 arg1Of inhibitor,The
R7633 T9189 T9187 arg1Of inhibitor,NF-κB
R7634 T9189 T9188 arg1Of inhibitor,activation
R7635 T9189 T9190 arg1Of inhibitor,(
R7636 T9189 T9193 arg1Of inhibitor,showed
R7637 T9189 T9198 arg1Of inhibitor,resulted
R7638 T9191 T9190 arg2Of NAI,(
R7639 T9042 T9040 arg2Of h,at
R7640 T9192 T9190 arg3Of ),(
R7641 T9042 T9041 arg1Of h,2-6
R7642 T9045 T9043 arg2Of exposure,after
R7643 T9193 T9195 arg1Of showed,against
R7644 T9193 T9197 arg1Of showed,and
R7645 T9194 T9193 arg2Of specificity,showed
R7646 T9045 T9044 arg1Of exposure,PMA
R7647 T9196 T9195 arg2Of NF-κB,against
R7648 T9048 T9046 arg1Of expression,The
R7649 T9198 T9197 arg2Of resulted,and
R7650 T9198 T9199 arg1Of resulted,in
R7651 T9198 T9204 arg1Of resulted,following
R7652 T9048 T9047 arg1Of expression,CXCL8
R7653 T9048 T9049 arg1Of expression,did
R7654 T9203 T9199 arg2Of inhibition,in
R7655 T9203 T9200 arg1Of inhibition,a
R7656 T9203 T9201 arg1Of inhibition,complete
R7657 T9203 T9202 arg1Of inhibition,IL-6
R7658 T9048 T9051 arg1Of expression,correlate
R7659 T9205 T9204 arg2Of induction,following
R7660 T9205 T9206 arg1Of induction,with
R7661 T9051 T9049 arg2Of correlate,did
R7662 T9207 T9208 arg1Of PMA,and
R7663 T9208 T9206 arg2Of and,with
R7664 T9208 T9212 arg1Of and,after
R7665 T9211 T9208 arg2Of reduction,and
R7666 T9211 T9209 arg1Of reduction,significant
R7667 T9211 T9210 arg1Of reduction,IL-6
R7668 T9051 T9050 arg1Of correlate,not
R7669 T9051 T9052 arg1Of correlate,with
R7670 T9051 T9062 arg1Of correlate,with
R7671 T9052 T9061 arg1Of with,or
R7672 T9216 T9212 arg2Of treatment,after
R7673 T9216 T9213 arg1Of treatment,HK
R7674 T9216 T9214 arg1Of treatment,E.
R7675 T9216 T9215 arg1Of treatment,coli
R7676 T9217 T9218 arg1Of CXCL8,was
R7677 T9217 T9221 arg2Of CXCL8,regulated
R7678 T9056 T9052 arg2Of activation,with
R7679 T9221 T9218 arg2Of regulated,was
R7680 T9221 T9219 arg1Of regulated,highly
R7681 T9221 T9220 arg1Of regulated,up
R7682 T9221 T9224 arg1Of regulated,and
R7683 T9223 T9221 arg1Of PMA,regulated
R7684 T9223 T9222 arg2Of PMA,by
R7685 T9226 T9225 arg1Of addition,the
R7686 T9226 T9227 arg1Of addition,of
R7687 T9226 T9229 arg1Of addition,resulted
R7688 T9228 T9227 arg2Of NAI,of
R7689 T9229 T9224 arg2Of resulted,and
R7690 T9229 T9230 arg1Of resulted,in
R7691 T9056 T9053 arg1Of activation,the
R7692 T9056 T9054 arg1Of activation,early
R7693 T9056 T9055 arg1Of activation,NF-κB
R7694 T9233 T9230 arg2Of reduction,in
R7695 T9233 T9231 arg1Of reduction,a
R7696 T9233 T9232 arg1Of reduction,minor
R7697 T9233 T9234 arg1Of reduction,in
R7698 T9056 T9057 arg1Of activation,(
R7699 T9059 T9057 arg2Of min,(
R7700 T9236 T9234 arg2Of expression,in
R7701 T9236 T9235 arg1Of expression,CXCL8
R7702 T9240 T9239 arg1Of expression,CXCL8
R7703 T9059 T9058 arg1Of min,1
R7704 T9060 T9057 arg3Of ),(
R7705 T9240 T9241 arg1Of expression,was
R7706 T9240 T9243 arg2Of expression,affected
R7707 T9062 T9061 arg2Of with,or
R7708 T9243 T9237 arg1Of affected,Furthermore
R7709 T9243 T9238 arg1Of affected,","
R7710 T9243 T9241 arg2Of affected,was
R7711 T9243 T9242 arg1Of affected,not
R7712 T9243 T9246 arg1Of affected,following
R7713 T9243 T9251 arg1Of affected,","
R7714 T9243 T9252 modOf affected,indicating
R7715 T9245 T9243 arg1Of NAI,affected
R7716 T9245 T9244 arg2Of NAI,by
R7717 T9064 T9062 arg2Of down-regulation,with
R7718 T9064 T9063 arg1Of down-regulation,the
R7719 T9250 T9246 arg2Of treatment,following
R7720 T9250 T9247 arg1Of treatment,HK
R7721 T9250 T9248 arg1Of treatment,E.
R7722 T9250 T9249 arg1Of treatment,coli
R7723 T9064 T9065 arg1Of down-regulation,of
R7724 T9064 T9067 arg1Of down-regulation,at
R7725 T9066 T9065 arg2Of NF-κB,of
R7726 T9254 T9252 arg2Of lack,indicating
R7727 T9254 T9253 arg1Of lack,a
R7728 T9254 T9255 arg1Of lack,of
R7729 T9254 T9257 arg1Of lack,between
R7730 T9256 T9255 arg2Of correlation,of
R7731 T9258 T9259 arg1Of CXCL8,and
R7732 T9259 T9257 arg2Of and,between
R7733 T9260 T9259 arg2Of NF-κB,and
R7734 T9071 T9067 arg2Of exposure,at
R7735 T9262 T9261 arg1Of analysis,Further
R7736 T9262 T9263 arg1Of analysis,of
R7737 T9262 T9266 arg1Of analysis,revealed
R7738 T9265 T9263 arg2Of expression,of
R7739 T9265 T9264 arg1Of expression,CXCL8
R7740 T9266 T9274 arg1Of revealed,","
R7741 T9266 T9275 modOf revealed,suggesting
R7742 T9268 T9266 arg2Of down-regulation,revealed
R7743 T9268 T9267 arg1Of down-regulation,a
R7744 T9268 T9269 arg1Of down-regulation,by
R7745 T9071 T9068 arg1Of exposure,2
R7746 T9270 T9271 arg1Of PKC-,and
R7747 T9071 T9069 arg1Of exposure,h
R7748 T9071 T9070 arg1Of exposure,post
R7749 T9272 T9271 arg2Of JNK-,and
R7750 T9273 T9269 arg2Of inhibitors,by
R7751 T9273 T9270 arg1Of inhibitors,PKC-
R7752 T9273 T9272 arg1Of inhibitors,JNK-
R7753 T9073 T9074 arg1Of IL-6,and
R7754 T9275 T9284 arg1Of suggesting,","
R7755 T9275 T9285 arg1Of suggesting,respectively
R7756 T9277 T9275 arg2Of involvement,suggesting
R7757 T9277 T9276 arg1Of involvement,an
R7758 T9277 T9278 arg1Of involvement,of
R7759 T9277 T9280 arg1Of involvement,via
R7760 T9074 T9072 arg1Of and,Both
R7761 T9279 T9278 arg2Of AP-1,of
R7762 T9281 T9282 arg1Of PKC,and
R7763 T9074 T9077 arg1Of and,were
R7764 T9282 T9280 arg2Of and,via
R7765 T9283 T9282 arg2Of JNK,and
R7766 T9074 T9079 arg2Of and,regulated
R7767 T9076 T9074 arg2Of expression,and
R7768 T9286 T9287 arg1Of Analysis,of
R7769 T9286 T9291 arg1Of Analysis,confirmed
R7770 T9076 T9075 arg1Of expression,TNF
R7771 T9289 T9287 arg2Of expression,of
R7772 T9289 T9288 arg1Of expression,gene
R7773 T9079 T9077 arg2Of regulated,were
R7774 T9079 T9078 arg1Of regulated,up
R7775 T9079 T9080 arg1Of regulated,between
R7776 T9082 T9080 arg2Of h,between
R7777 T9291 T9290 arg1Of confirmed,further
R7778 T9293 T9294 arg1Of il-6,and
R7779 T9082 T9081 arg1Of h,6-24
R7780 T9294 T9296 arg1Of and,were
R7781 T9294 T9297 arg2Of and,upregulated
R7782 T9295 T9294 arg2Of cxcl8,and
R7783 T9085 T9083 arg2Of period,During
R7784 T9297 T9291 arg2Of upregulated,confirmed
R7785 T9297 T9292 arg1Of upregulated,that
R7786 T9297 T9296 arg2Of upregulated,were
R7787 T9299 T9297 arg1Of PMA,upregulated
R7788 T9299 T9298 arg2Of PMA,by
R7789 T9300 T9301 arg1Of Expression,of
R7790 T9300 T9303 arg1Of Expression,dropped
R7791 T9302 T9301 arg2Of il-6,of
R7792 T9303 T9304 arg1Of dropped,below
R7793 T9303 T9307 arg1Of dropped,following
R7794 T9303 T9313 arg1Of dropped,whereas
R7795 T9085 T9084 arg1Of period,this
R7796 T9087 T9088 arg1Of NF-κB,increased
R7797 T9306 T9304 arg2Of levels,below
R7798 T9306 T9305 arg1Of levels,basal
R7799 T9308 T9307 arg2Of inhibition,following
R7800 T9308 T9309 arg1Of inhibition,of
R7801 T9310 T9311 arg1Of NF-κB,and
R7802 T9088 T9083 arg1Of increased,During
R7803 T9311 T9309 arg2Of and,of
R7804 T9312 T9311 arg2Of JNK,and
R7805 T9088 T9086 arg1Of increased,","
R7806 T9314 T9315 arg1Of cxcl8,remained
R7807 T9088 T9089 arg1Of increased,from
R7808 T9092 T9089 arg2Of level,from
R7809 T9314 T9316 arg1Of cxcl8,elevated
R7810 T9315 T9313 arg2Of remained,whereas
R7811 T9315 T9317 arg1Of remained,above
R7812 T9315 T9326 arg1Of remained,following
R7813 T9316 T9315 arg2Of elevated,remained
R7814 T9092 T9090 arg1Of level,its
R7815 T9092 T9091 arg1Of level,minimum
R7816 T9092 T9093 arg1Of level,at
R7817 T9319 T9317 arg2Of levels,above
R7818 T9319 T9318 arg1Of levels,basal
R7819 T9319 T9320 arg1Of levels,(
R7820 T9321 T9322 arg1Of 16.5-fold,and
R7821 T9322 T9320 arg2Of and,(
R7822 T9322 T9324 arg1Of and,respectively
R7823 T9095 T9093 arg2Of h,at
R7824 T9323 T9322 arg2Of 7.1-fold,and
R7825 T9325 T9320 arg3Of ),(
R7826 T9095 T9094 arg1Of h,6
R7827 T9387 T9384 arg1Of NF-κB,The
R7828 T9329 T9326 arg2Of treatment,following
R7829 T9329 T9327 arg1Of treatment,the
R7830 T9329 T9328 arg1Of treatment,same
R7831 T9332 T9333 arg1Of inhibition,of
R7832 T9332 T9335 arg1Of inhibition,did
R7833 T9332 T9337 arg1Of inhibition,result
R7834 T9334 T9333 arg2Of PKC,of
R7835 T9337 T9330 arg1Of result,Furthermore
R7836 T9337 T9331 arg1Of result,","
R7837 T9337 T9335 arg2Of result,did
R7838 T9337 T9336 arg1Of result,not
R7839 T9337 T9338 arg1Of result,in
R7840 T9337 T9346 arg1Of result,","
R7841 T9337 T9347 arg1Of result,which
R7842 T9337 T9348 arg1Of result,is
R7843 T9387 T9385 arg1Of NF-κB,transcription
R7844 T9337 T9349 arg1Of result,in
R7845 T9387 T9386 arg1Of NF-κB,factor
R7846 T9387 T9388 arg1Of NF-κB,is
R7847 T9387 T9389 arg1Of NF-κB,responsible
R7848 T9389 T9388 arg2Of responsible,is
R7849 T9341 T9338 arg2Of decrease,in
R7850 T9341 T9339 arg1Of decrease,a
R7851 T9341 T9340 arg1Of decrease,significant
R7852 T9341 T9342 arg1Of decrease,of
R7853 T9343 T9344 arg1Of il-6,or
R7854 T9344 T9342 arg2Of or,of
R7855 T9345 T9344 arg2Of cxcl8,or
R7856 T9389 T9390 arg1Of responsible,for
R7857 T9394 T9390 arg2Of response,for
R7858 T9349 T9348 arg2Of in,is
R7859 T9350 T9349 arg2Of accordance,in
R7860 T9350 T9351 arg1Of accordance,with
R7861 T9353 T9351 arg2Of data,with
R7862 T9353 T9352 arg1Of data,protein
R7863 T9353 T9354 arg1Of data,(
R7864 T9394 T9391 arg1Of response,a
R7865 T9355 T9354 arg2Of figure,(
R7866 T9355 T9356 arg1Of figure,6
R7867 T9394 T9392 arg1Of response,rapid
R7868 T9394 T9393 arg1Of response,immune
R7869 T9357 T9354 arg3Of ),(
R7870 T9394 T9395 arg1Of response,which
R7871 T9359 T9358 arg1Of results,These
R7872 T9359 T9360 arg1Of results,suggest
R7873 T9394 T9396 arg1Of response,is
R7874 T9394 T9397 arg2Of response,followed
R7875 T9362 T9363 arg1Of NF-κB,is
R7876 T9362 T9364 arg2Of NF-κB,involved
R7877 T9397 T9396 arg2Of followed,is
R7878 T9364 T9360 arg2Of involved,suggest
R7879 T9364 T9361 arg1Of involved,that
R7880 T9364 T9363 arg2Of involved,is
R7881 T9364 T9365 arg1Of involved,in
R7882 T9364 T9370 arg1Of involved,while
R7883 T9367 T9366 arg1Of regulation,IL-6
R7884 T9367 T9368 arg1Of regulation,and
R7885 T9368 T9365 arg2Of and,in
R7886 T9369 T9368 arg2Of release,and
R7887 T9371 T9372 arg1Of it,is
R7888 T9371 T9374 arg2Of it,required
R7889 T9400 T9397 arg1Of increase,followed
R7890 T9374 T9370 arg2Of required,while
R7891 T9374 T9372 arg2Of required,is
R7892 T9374 T9373 arg1Of required,not
R7893 T9374 T9375 arg1Of required,for
R7894 T9377 T9375 arg2Of expression,for
R7895 T9377 T9376 arg1Of expression,the
R7896 T9377 T9378 arg1Of expression,of
R7897 T9377 T9380 arg1Of expression,in
R7898 T9400 T9398 arg2Of increase,by
R7899 T9379 T9378 arg2Of CXCL8,of
R7900 T9400 T9399 arg1Of increase,an
R7901 T9400 T9401 arg1Of increase,in
R7902 T9402 T9401 arg2Of transcription,in
R7903 T9383 T9380 arg2Of cells,in
R7904 T9383 T9381 arg1Of cells,Jurkat
R7905 T9383 T9382 arg1Of cells,T
R7906 T9402 T9403 arg1Of transcription,of
R7907 T9402 T9406 arg1Of transcription,inhibiting
R7908 T9404 T9403 arg2Of IκB,of
R7909 T9406 T9405 arg1Of inhibiting,thus
R7910 T9407 T9406 arg2Of NF-κB,inhibiting
R7911 T9484 T9481 arg2Of and,via
R7912 T9484 T9482 arg1Of and,the
R7913 T9485 T9484 arg2Of PKC,and
R7914 T9407 T9408 arg1Of NF-κB,[
R7915 T9486 T9487 arg1Of resulted,in
R7916 T9409 T9408 arg2Of 46,[
R7917 T9410 T9408 arg3Of ],[
R7918 T9490 T9487 arg2Of down-regulation,in
R7919 T9490 T9488 arg1Of down-regulation,a
R7920 T9490 T9489 arg1Of down-regulation,concomitant
R7921 T9490 T9491 arg1Of down-regulation,of
R7922 T9492 T9491 arg2Of NF-κB,of
R7923 T9493 T9494 arg1Of They,suggested
R7924 T9411 T9412 arg1Of Activation,of
R7925 T9496 T9497 arg1Of Bcl10,is
R7926 T9496 T9499 arg2Of Bcl10,activated
R7927 T9411 T9414 arg1Of Activation,in
R7928 T9411 T9417 arg1Of Activation,is
R7929 T9411 T9418 arg1Of Activation,dependent
R7930 T9499 T9495 arg1Of activated,that
R7931 T9499 T9497 arg2Of activated,is
R7932 T9499 T9498 arg1Of activated,initially
R7933 T9499 T9502 arg1Of activated,but
R7934 T9501 T9499 arg1Of TCR/PKC,activated
R7935 T9501 T9500 arg2Of TCR/PKC,by
R7936 T9502 T9494 arg2Of but,suggested
R7937 T9503 T9502 arg2Of that,but
R7938 T9413 T9412 arg2Of NF-κB,of
R7939 T9505 T9504 arg1Of activation,continued
R7940 T9505 T9506 arg1Of activation,(
R7941 T9505 T9511 arg1Of activation,promotes
R7942 T9416 T9414 arg2Of T-cells,in
R7943 T9508 T9507 arg1Of 1,>
R7944 T9509 T9506 arg2Of h,(
R7945 T9509 T9508 arg1Of h,1
R7946 T9510 T9506 arg3Of ),(
R7947 T9511 T9503 arg2Of promotes,that
R7948 T9416 T9415 arg1Of T-cells,Jurkat
R7949 T9513 T9511 arg2Of degradation,promotes
R7950 T9513 T9512 arg1Of degradation,its
R7951 T9514 T9515 arg1Of Narayan,and
R7952 T9418 T9417 arg2Of dependent,is
R7953 T9515 T9517 arg1Of and,[
R7954 T9515 T9520 arg1Of and,suggested
R7955 T9516 T9515 arg2Of colleagues,and
R7956 T9518 T9517 arg2Of 27,[
R7957 T9418 T9419 arg1Of dependent,on
R7958 T9519 T9517 arg3Of ],[
R7959 T9421 T9419 arg2Of activation,on
R7960 T9522 T9523 arg1Of deletion,in
R7961 T9522 T9531 arg1Of deletion,impairs
R7962 T9524 T9523 arg2Of any,in
R7963 T9524 T9525 arg1Of any,of
R7964 T9421 T9420 arg1Of activation,Bcl10
R7965 T9421 T9422 arg1Of activation,","
R7966 T9421 T9423 arg1Of activation,which
R7967 T9421 T9426 arg1Of activation,is
R7968 T9421 T9427 arg2Of activation,regulated
R7969 T9530 T9525 arg2Of proteins,of
R7970 T9530 T9526 arg1Of proteins,the
R7971 T9530 T9527 arg1Of proteins,three
R7972 T9530 T9528 arg1Of proteins,CBM
R7973 T9530 T9529 arg1Of proteins,complex
R7974 T9531 T9520 arg2Of impairs,suggested
R7975 T9531 T9521 arg1Of impairs,that
R7976 T9425 T9424 arg2Of turn,in
R7977 T9534 T9531 arg2Of activation,impairs
R7978 T9534 T9532 arg1Of activation,antigen-receptor
R7979 T9534 T9533 arg1Of activation,dependent
R7980 T9534 T9535 arg1Of activation,of
R7981 T9536 T9535 arg2Of NF-κB,of
R7982 T9537 T9538 arg1Of They,showed
R7983 T9427 T9424 arg1Of regulated,in
R7984 T9541 T9540 arg1Of activation,NF-κB
R7985 T9541 T9542 arg1Of activation,via
R7986 T9541 T9544 arg1Of activation,requires
R7987 T9541 T9547 arg1Of activation,acts
R7988 T9427 T9426 arg2Of regulated,is
R7989 T9429 T9427 arg1Of PKC,regulated
R7990 T9543 T9542 arg2Of Akt,via
R7991 T9544 T9546 arg1Of requires,and
R7992 T9545 T9544 arg2Of CARMA1,requires
R7993 T9546 T9538 arg2Of and,showed
R7994 T9546 T9539 arg1Of and,that
R7995 T9429 T9428 arg2Of PKC,by
R7996 T9547 T9546 arg2Of acts,and
R7997 T9547 T9548 arg1Of acts,in
R7998 T9431 T9430 arg1Of studies,Recent
R7999 T9549 T9548 arg2Of cooperation,in
R8000 T9549 T9550 arg1Of cooperation,with
R8001 T9551 T9550 arg2Of PKC,with
R8002 T9551 T9552 arg1Of PKC,following
R8003 T9431 T9432 arg1Of studies,have
R8004 T9554 T9552 arg2Of exposure,following
R8005 T9554 T9553 arg1Of exposure,short-term
R8006 T9554 T9555 arg1Of exposure,(
R8007 T9554 T9559 arg1Of exposure,of
R8008 T9554 T9562 arg1Of exposure,with
R8009 T9431 T9433 arg1Of studies,established
R8010 T9433 T9432 arg2Of established,have
R8011 T9557 T9555 arg2Of min,(
R8012 T9557 T9556 arg1Of min,30
R8013 T9558 T9555 arg3Of ),(
R8014 T9435 T9433 arg2Of importance,established
R8015 T9561 T9559 arg2Of T-cells,of
R8016 T9561 T9560 arg1Of T-cells,Jurkat
R8017 T9563 T9562 arg2Of PMA,with
R8018 T9564 T9565 arg1Of Akt,phosphorylates
R8019 T9564 T9568 arg1Of Akt,activates
R8020 T9435 T9434 arg1Of importance,the
R8021 T9565 T9566 arg1Of phosphorylates,and
R8022 T9435 T9436 arg1Of importance,of
R8023 T9435 T9440 arg1Of importance,consisting
R8024 T9568 T9566 arg2Of activates,and
R8025 T9568 T9567 arg1Of activates,thus
R8026 T9569 T9568 arg2Of Bcl10,activates
R8027 T9439 T9436 arg2Of complex,of
R8028 T9571 T9570 arg1Of studies,These
R8029 T9571 T9572 arg1Of studies,indicate
R8030 T9574 T9575 arg1Of PKC,is
R8031 T9574 T9576 arg1Of PKC,crucial
R8032 T9575 T9573 arg1Of is,that
R8033 T9575 T9587 arg1Of is,bound
R8034 T9576 T9575 arg2Of crucial,is
R8035 T9576 T9577 arg1Of crucial,for
R8036 T9439 T9437 arg1Of complex,a
R8037 T9579 T9577 arg2Of activation,for
R8038 T9579 T9578 arg1Of activation,NF-κB
R8039 T9579 T9580 arg1Of activation,following
R8040 T9580 T9583 arg1Of following,through
R8041 T9439 T9438 arg1Of complex,protein
R8042 T9440 T9441 arg1Of consisting,of
R8043 T9442 T9443 arg1Of CARMA1,","
R8044 T9443 T9445 arg1Of ",",and
R8045 T9444 T9443 arg2Of Bcl10,","
R8046 T9582 T9580 arg2Of treatment,following
R8047 T9582 T9581 arg1Of treatment,short-term
R8048 T9584 T9583 arg2Of signals,through
R8049 T9584 T9585 arg1Of signals,via
R8050 T9445 T9441 arg2Of and,of
R8051 T9586 T9585 arg2Of membrane,via
R8052 T9587 T9572 arg2Of bound,indicate
R8053 T9445 T9450 arg1Of and,","
R8054 T9588 T9587 arg2Of receptors,bound
R8055 T9588 T9590 arg1Of receptors,as
R8056 T9445 T9451 arg1Of and,in
R8057 T9590 T9589 arg1Of as,such
R8058 T9446 T9445 arg2Of MALT1,and
R8059 T9592 T9591 arg1Of TCR,the
R8060 T9592 T9593 arg1Of TCR,and
R8061 T9593 T9590 arg2Of and,as
R8062 T9446 T9447 arg1Of MALT1,(
R8063 T9448 T9447 arg2Of CBM,(
R8064 T9597 T9593 arg2Of CD28,and
R8065 T9597 T9594 arg1Of CD28,the
R8066 T9597 T9595 arg1Of CD28,co-stimulatory
R8067 T9597 T9596 arg1Of CD28,receptor
R8068 T9449 T9447 arg3Of ),(
R8069 T9453 T9451 arg2Of induction,in
R8070 T9603 T9600 arg1Of proteins,the
R8071 T9603 T9601 arg1Of proteins,CBM
R8072 T9603 T9602 arg1Of proteins,complex
R8073 T9603 T9604 arg1Of proteins,play
R8074 T9604 T9598 arg1Of play,Thus
R8075 T9604 T9599 arg1Of play,","
R8076 T9604 T9608 arg1Of play,in
R8077 T9607 T9604 arg2Of role,play
R8078 T9607 T9605 arg1Of role,a
R8079 T9607 T9606 arg1Of role,key
R8080 T9611 T9608 arg2Of process,in
R8081 T9611 T9609 arg1Of process,this
R8082 T9611 T9610 arg1Of process,signalling
R8083 T9612 T9613 arg1Of PMA,diffuses
R8084 T9453 T9452 arg1Of induction,the
R8085 T9612 T9619 arg1Of PMA,activates
R8086 T9453 T9454 arg1Of induction,of
R8087 T9613 T9614 arg1Of diffuses,into
R8088 T9613 T9617 arg1Of diffuses,and
R8089 T9455 T9454 arg2Of NF-κB,of
R8090 T9616 T9614 arg2Of cytosol,into
R8091 T9616 T9615 arg1Of cytosol,the
R8092 T9457 T9458 arg1Of Bcl10,","
R8093 T9619 T9617 arg2Of activates,and
R8094 T9619 T9618 arg1Of activates,directly
R8095 T9619 T9621 arg1Of activates,since
R8096 T9620 T9619 arg2Of PKC,activates
R8097 T9458 T9460 arg1Of ",",and
R8098 T9622 T9623 arg1Of it,is
R8099 T9623 T9621 arg2Of is,since
R8100 T9459 T9458 arg2Of Scharschmidt,","
R8101 T9625 T9623 arg2Of analogue,is
R8102 T9625 T9624 arg1Of analogue,an
R8103 T9625 T9626 arg1Of analogue,to
R8104 T9460 T9456 arg1Of and,Investigating
R8105 T9627 T9626 arg2Of diacylglycerol,to
R8106 T9627 T9628 arg1Of diacylglycerol,[
R8107 T9629 T9628 arg2Of 48,[
R8108 T9460 T9462 arg1Of and,[
R8109 T9630 T9628 arg3Of ],[
R8110 T9460 T9465 arg1Of and,demonstrated
R8111 T9632 T9631 arg1Of studies,Several
R8112 T9632 T9633 arg1Of studies,have
R8113 T9632 T9634 arg1Of studies,demonstrated
R8114 T9461 T9460 arg2Of colleagues,and
R8115 T9634 T9633 arg2Of demonstrated,have
R8116 T9463 T9462 arg2Of 47,[
R8117 T9636 T9637 arg1Of inhibition,of
R8118 T9636 T9639 arg1Of inhibition,blocks
R8119 T9636 T9645 arg1Of inhibition,suggesting
R8120 T9638 T9637 arg2Of PKC,of
R8121 T9639 T9634 arg2Of blocks,demonstrated
R8122 T9639 T9635 arg1Of blocks,that
R8123 T9639 T9644 arg1Of blocks,","
R8124 T9639 T9655 arg1Of blocks,[
R8125 T9640 T9641 arg1Of NF-κB,and
R8126 T9464 T9462 arg3Of ],[
R8127 T9642 T9641 arg2Of AP-1,and
R8128 T9643 T9639 arg2Of activity,blocks
R8129 T9643 T9640 arg1Of activity,NF-κB
R8130 T9643 T9642 arg1Of activity,AP-1
R8131 T9645 T9639 arg3Of suggesting,blocks
R8132 T9645 T9653 arg1Of suggesting,by
R8133 T9648 T9645 arg2Of regulation,suggesting
R8134 T9648 T9646 arg1Of regulation,a
R8135 T9648 T9647 arg1Of regulation,direct
R8136 T9648 T9649 arg1Of regulation,of
R8137 T9467 T9468 arg1Of it,is
R8138 T9652 T9649 arg2Of factors,of
R8139 T9652 T9650 arg1Of factors,these
R8140 T9652 T9651 arg1Of factors,transcription
R8141 T9654 T9653 arg2Of PKC,by
R8142 T9468 T9465 arg2Of is,demonstrated
R8143 T9656 T9655 arg2Of "49,50",[
R8144 T9657 T9655 arg3Of ],[
R8145 T9658 T9659 arg1Of PKC,is
R8146 T9658 T9660 arg2Of PKC,activated
R8147 T9658 T9669 arg1Of PKC,is
R8148 T9468 T9466 arg1Of is,that
R8149 T9660 T9659 arg2Of activated,is
R8150 T9660 T9661 arg1Of activated,at
R8151 T9660 T9665 arg1Of activated,following
R8152 T9660 T9668 arg1Of activated,and
R8153 T9471 T9468 arg2Of regulator,is
R8154 T9664 T9661 arg2Of stage,at
R8155 T9664 T9662 arg1Of stage,an
R8156 T9664 T9663 arg1Of stage,early
R8157 T9471 T9469 arg1Of regulator,a
R8158 T9667 T9665 arg2Of stimulation,following
R8159 T9667 T9666 arg1Of stimulation,T-cell
R8160 T9471 T9470 arg1Of regulator,critical
R8161 T9669 T9668 arg2Of is,and
R8162 T9669 T9670 arg1Of is,therefore
R8163 T9471 T9472 arg1Of regulator,of
R8164 T9474 T9472 arg2Of activity,of
R8165 T9673 T9669 arg2Of regulator,is
R8166 T9673 T9671 arg1Of regulator,an
R8167 T9673 T9672 arg1Of regulator,important
R8168 T9673 T9674 arg1Of regulator,of
R8169 T9474 T9473 arg1Of activity,NF-κB
R8170 T9475 T9476 arg1Of Down-regulation,of
R8171 T9475 T9478 arg1Of Down-regulation,from
R8172 T9475 T9486 arg1Of Down-regulation,resulted
R8173 T9477 T9476 arg2Of Bcl10,of
R8174 T9678 T9674 arg2Of pathways,of
R8175 T9678 T9675 arg1Of pathways,downstream
R8176 T9678 T9676 arg1Of pathways,inflammatory
R8177 T9678 T9677 arg1Of pathways,signalling
R8178 T9678 T9679 arg1Of pathways,leading
R8179 T9679 T9680 arg1Of leading,to
R8180 T9679 T9683 arg1Of leading,[
R8181 T9479 T9478 arg2Of signals,from
R8182 T9682 T9680 arg2Of expression,to
R8183 T9682 T9681 arg1Of expression,cytokine
R8184 T9684 T9683 arg2Of 50,[
R8185 T9685 T9683 arg3Of ],[
R8186 T9686 T9687 arg1Of We,have
R8187 T9479 T9480 arg2Of signals,transduced
R8188 T9686 T9688 arg1Of We,shown
R8189 T9480 T9481 arg1Of transduced,via
R8190 T9688 T9687 arg2Of shown,have
R8191 T9483 T9484 arg1Of TCR/CD28,and
R8192 T9690 T9691 arg1Of phosphorylated-PKC,is
R8193 T9690 T9693 arg2Of phosphorylated-PKC,regulated
R8194 T9693 T9688 arg2Of regulated,shown
R8195 T9693 T9689 arg1Of regulated,that
R8196 T9693 T9691 arg2Of regulated,is
R8197 T9693 T9692 arg1Of regulated,up
R8198 T9693 T9694 arg1Of regulated,in
R8199 T9693 T9702 arg1Of regulated,","
R8200 T9693 T9703 modOf regulated,indicating
R8201 T9778 T9776 arg1Of activation,prolonged
R8202 T9695 T9694 arg2Of response,in
R8203 T9695 T9696 arg1Of response,to
R8204 T9697 T9698 arg1Of PMA,and
R8205 T9698 T9696 arg2Of and,to
R8206 T9699 T9698 arg2Of HK,and
R8207 T9701 T9694 arg3Of coli,in
R8208 T9701 T9700 arg1Of coli,E.
R8209 T9778 T9777 arg1Of activation,PKC
R8210 T9778 T9779 arg1Of activation,by
R8211 T9778 T9781 arg1Of activation,leads
R8212 T9780 T9779 arg2Of PMA,by
R8213 T9705 T9703 arg2Of association,indicating
R8214 T9705 T9704 arg1Of association,an
R8215 T9705 T9706 arg1Of association,between
R8216 T9781 T9774 arg2Of leads,demonstrating
R8217 T9707 T9708 arg1Of PKC,and
R8218 T9781 T9775 arg1Of leads,that
R8219 T9708 T9706 arg2Of and,between
R8220 T9781 T9782 arg1Of leads,to
R8221 T9784 T9782 arg2Of inhibition,to
R8222 T9711 T9709 arg1Of factors,the
R8223 T9711 T9710 arg1Of factors,transcription
R8224 T9712 T9713 arg1Of AP-1,and
R8225 T9713 T9708 arg2Of and,and
R8226 T9713 T9711 arg1Of and,factors
R8227 T9714 T9713 arg2Of NF-κB,and
R8228 T9716 T9715 arg1Of levels,Bcl10
R8229 T9716 T9717 arg1Of levels,were
R8230 T9716 T9718 arg2Of levels,down-regulated
R8231 T9784 T9783 arg1Of inhibition,an
R8232 T9718 T9717 arg2Of down-regulated,were
R8233 T9718 T9719 arg1Of down-regulated,following
R8234 T9721 T9719 arg2Of treatment,following
R8235 T9721 T9720 arg2Of treatment,extended
R8236 T9721 T9722 arg1Of treatment,of
R8237 T9721 T9725 arg1Of treatment,with
R8238 T9784 T9785 arg1Of inhibition,of
R8239 T9724 T9722 arg2Of T-cells,of
R8240 T9724 T9723 arg1Of T-cells,Jurkat
R8241 T9786 T9787 arg1Of Bcl10,and
R8242 T9726 T9725 arg2Of PMA,with
R8243 T9787 T9785 arg2Of and,of
R8244 T9730 T9727 arg2Of groups,In
R8245 T9730 T9728 arg1Of groups,the
R8246 T9730 T9729 arg1Of groups,control
R8247 T9788 T9787 arg2Of NF-κB,and
R8248 T9733 T9732 arg1Of loss,a
R8249 T9733 T9734 arg1Of loss,of
R8250 T9733 T9736 arg1Of loss,occurred
R8251 T9735 T9734 arg2Of Bcl10,of
R8252 T9789 T9790 arg1Of It,has
R8253 T9736 T9727 arg1Of occurred,In
R8254 T9736 T9731 arg1Of occurred,","
R8255 T9736 T9737 arg1Of occurred,after
R8256 T9736 T9740 arg1Of occurred,","
R8257 T9736 T9741 modOf occurred,followed
R8258 T9736 T9748 arg1Of occurred,","
R8259 T9736 T9749 arg1Of occurred,which
R8260 T9736 T9750 arg1Of occurred,is
R8261 T9736 T9751 arg1Of occurred,in
R8262 T9739 T9737 arg2Of h,after
R8263 T9739 T9738 arg1Of h,6
R8264 T9789 T9791 arg1Of It,been
R8265 T9789 T9792 arg2Of It,shown
R8266 T9792 T9790 arg2Of shown,has
R8267 T9744 T9741 arg1Of increase,followed
R8268 T9744 T9742 arg2Of increase,by
R8269 T9744 T9743 arg1Of increase,an
R8270 T9744 T9745 arg1Of increase,after
R8271 T9747 T9745 arg2Of h,after
R8272 T9747 T9746 arg1Of h,24
R8273 T9792 T9791 arg2Of shown,been
R8274 T9794 T9795 arg1Of NF-κB,is
R8275 T9751 T9750 arg2Of in,is
R8276 T9752 T9751 arg2Of accordance,in
R8277 T9752 T9753 arg1Of accordance,with
R8278 T9795 T9792 arg3Of is,shown
R8279 T9795 T9793 arg1Of is,that
R8280 T9757 T9753 arg2Of activity,with
R8281 T9757 T9754 arg1Of activity,the
R8282 T9757 T9755 arg2Of activity,observed
R8283 T9757 T9756 arg1Of activity,NF-κB
R8284 T9757 T9758 arg1Of activity,(
R8285 T9759 T9758 arg2Of figure,(
R8286 T9800 T9795 arg2Of complex,is
R8287 T9759 T9760 arg1Of figure,7
R8288 T9761 T9758 arg3Of ),(
R8289 T9763 T9762 arg1Of results,These
R8290 T9763 T9764 arg1Of results,are
R8291 T9763 T9765 arg2Of results,supported
R8292 T9765 T9764 arg2Of supported,are
R8293 T9765 T9773 arg1Of supported,","
R8294 T9765 T9774 modOf supported,demonstrating
R8295 T9800 T9796 arg1Of complex,an
R8296 T9800 T9797 arg1Of complex,important
R8297 T9769 T9765 arg1Of study,supported
R8298 T9769 T9766 arg2Of study,by
R8299 T9769 T9767 arg1Of study,an
R8300 T9769 T9768 arg1Of study,earlier
R8301 T9769 T9770 arg1Of study,[
R8302 T9800 T9798 arg1Of complex,transcription
R8303 T9771 T9770 arg2Of 47,[
R8304 T9800 T9799 arg1Of complex,factor
R8305 T9772 T9770 arg3Of ],[
R8306 T9800 T9801 arg2Of complex,involved
R8307 T9801 T9802 arg1Of involved,in
R8308 T9804 T9803 arg1Of every,almost
R8309 T9805 T9802 arg2Of aspect,in
R8310 T9872 T9871 arg2Of secretion,following
R8311 T9872 T9873 arg1Of secretion,of
R8312 T9805 T9804 arg1Of aspect,every
R8313 T9805 T9806 arg1Of aspect,of
R8314 T9875 T9873 arg2Of cytokines,of
R8315 T9875 T9874 arg1Of cytokines,pro-inflammatory
R8316 T9808 T9806 arg2Of regulation,of
R8317 T9879 T9876 arg2Of persons,In
R8318 T9879 T9877 arg1Of persons,HIV
R8319 T9879 T9878 arg1Of persons,infected
R8320 T9808 T9807 arg1Of regulation,cell
R8321 T9808 T9809 arg1Of regulation,including
R8322 T9883 T9881 arg1Of levels,serum
R8323 T9883 T9882 arg1Of levels,CXCL8
R8324 T9883 T9884 arg1Of levels,are
R8325 T9883 T9885 arg2Of levels,elevated
R8326 T9810 T9811 arg1Of apoptosis,","
R8327 T9885 T9884 arg2Of elevated,are
R8328 T9885 T9886 arg1Of elevated,and
R8329 T9886 T9876 arg1Of and,In
R8330 T9886 T9880 arg1Of and,","
R8331 T9887 T9888 arg1Of this,could
R8332 T9887 T9889 arg1Of this,recruit
R8333 T9889 T9886 arg2Of recruit,and
R8334 T9889 T9888 arg2Of recruit,could
R8335 T9889 T9902 arg1Of recruit,since
R8336 T9891 T9889 arg2Of T-cells,recruit
R8337 T9891 T9890 arg1Of T-cells,more
R8338 T9811 T9813 arg1Of ",",","
R8339 T9891 T9893 arg1Of T-cells,leading
R8340 T9812 T9811 arg2Of differentiation,","
R8341 T9813 T9815 arg1Of ",",and
R8342 T9893 T9892 arg1Of leading,potentially
R8343 T9893 T9894 arg1Of leading,to
R8344 T9814 T9813 arg2Of proliferation,","
R8345 T9897 T9896 arg1Of rapid,more
R8346 T9898 T9894 arg2Of progression,to
R8347 T9898 T9895 arg1Of progression,a
R8348 T9898 T9897 arg1Of progression,rapid
R8349 T9898 T9899 arg1Of progression,of
R8350 T9815 T9809 arg2Of and,including
R8351 T9901 T9899 arg2Of disease,of
R8352 T9901 T9900 arg1Of disease,the
R8353 T9815 T9817 arg1Of and,of
R8354 T9903 T9904 arg1Of there,will
R8355 T9903 T9905 arg1Of there,be
R8356 T9815 T9820 arg1Of and,[
R8357 T9905 T9902 arg2Of be,since
R8358 T9905 T9904 arg2Of be,will
R8359 T9816 T9815 arg2Of initiation,and
R8360 T9907 T9905 arg2Of T-cells,be
R8361 T9907 T9906 arg1Of T-cells,more
R8362 T9819 T9817 arg2Of responses,of
R8363 T9907 T9908 arg1Of T-cells,available
R8364 T9819 T9818 arg1Of responses,immune
R8365 T9910 T9908 arg2Of infect,available
R8366 T9910 T9909 arg1Of infect,to
R8367 T9821 T9820 arg2Of 51-53,[
R8368 T9822 T9820 arg3Of ],[
R8369 T9823 T9824 arg1Of NF-κB,is
R8370 T9823 T9826 arg1Of NF-κB,active
R8371 T9826 T9824 arg2Of active,is
R8372 T9826 T9825 arg1Of active,constitutively
R8373 T9826 T9827 arg1Of active,in
R8374 T9830 T9827 arg2Of malignancies,in
R8377 T9830 T9828 arg1Of malignancies,many
R8381 T9830 T9829 arg1Of malignancies,human
R8382 T9830 T9831 arg1Of malignancies,","
R8383 T9830 T9832 arg1Of malignancies,which
R8384 T9830 T9833 arg1Of malignancies,makes
R8385 T9833 T9839 arg1Of makes,[
R8386 T9834 T9833 arg2Of it,makes
R8387 T9838 T9833 arg3Of target,makes
R8388 T9838 T9835 arg1Of target,an
R8389 T9838 T9836 arg1Of target,attractive
R8390 T9838 T9837 arg1Of target,therapeutic
R8391 T9840 T9839 arg2Of 54,[
R8392 T9841 T9839 arg3Of ],[
R8393 T9844 T9842 arg1Of levels,Elevated
R8394 T9844 T9843 arg1Of levels,CXCL8
R8395 T9844 T9845 arg1Of levels,during
R8396 T9844 T9848 arg1Of levels,result
R8397 T9847 T9845 arg2Of inflammation,during
R8398 T9847 T9846 arg1Of inflammation,chronic
R8399 T9848 T9849 arg1Of result,in
R8400 T9852 T9849 arg2Of recruitment,in
R8401 T9852 T9850 arg1Of recruitment,an
R8402 T9852 T9851 arg2Of recruitment,enhanced
R8403 T9852 T9853 arg1Of recruitment,of
R8404 T9852 T9856 arg1Of recruitment,to
R8405 T9855 T9853 arg2Of cells,of
R8406 T9855 T9854 arg1Of cells,immune
R8407 T9858 T9856 arg2Of site,to
R8408 T9858 T9857 arg1Of site,the
R8409 T9858 T9859 arg1Of site,of
R8410 T9858 T9861 arg1Of site,","
R8411 T9858 T9862 arg1Of site,which
R8412 T9858 T9863 arg1Of site,may
R8413 T9858 T9864 arg1Of site,lead
R8414 T9860 T9859 arg2Of infection,of
R8415 T9864 T9863 arg2Of lead,may
R8416 T9864 T9865 arg1Of lead,to
R8417 T9867 T9865 arg2Of development,to
R8418 T9867 T9866 arg1Of development,the
R8419 T9867 T9868 arg1Of development,of
R8420 T9870 T9868 arg2Of diseases,of
R8421 T9870 T9869 arg1Of diseases,autoimmune
R8422 T9870 T9871 arg1Of diseases,following

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T9912 6310-6319 Antecedent denotes activated
T9913 6377-6380 Anaphor denotes its
T9914 6291-6296 Antecedent denotes Bcl10
T9915 6456-6486 Anaphor denotes the three CBM complex proteins
T9916 5969-5975 Antecedent denotes CARMA1
T9917 5977-5982 Antecedent denotes Bcl10
T9918 5987-5992 Antecedent denotes MALT1
T9911 6335-6360 Anaphor denotes that continued activation
R8376 T9913 T9914 boundBy its,Bcl10
R8378 T9915 T9916 boundBy the three CBM complex proteins,CARMA1
R8379 T9915 T9917 boundBy the three CBM complex proteins,Bcl10
R8380 T9915 T9918 boundBy the three CBM complex proteins,MALT1
R8375 T9911 T9912 boundBy that continued activation,activated

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T6906 11-16 NN denotes NF-κB
T6907 17-20 CC denotes and
T6908 21-25 NN denotes AP-1
T6909 26-29 VBP denotes are
T6910 30-38 JJ denotes critical
T6911 39-49 NNS denotes regulators
T6912 50-52 IN denotes of
T6913 53-65 JJ denotes inflammatory
T6914 66-75 NNS denotes responses
T6915 75-76 , denotes ,
T6916 77-90 NN denotes proliferation
T6917 91-94 CC denotes and
T6918 95-110 NN denotes differentiation
T6919 111-113 IN denotes of
T6920 114-121 NNS denotes T-cells
T6921 122-123 NNP denotes [
T6922 123-128 CD denotes 28-30
T6923 128-129 NNP denotes ]
T6924 129-130 , denotes ,
T6925 131-138 RB denotes however
T6926 138-139 , denotes ,
T6927 140-143 DT denotes the
T6928 144-150 NN denotes signal
T6929 151-163 NN denotes transduction
T6930 164-167 CC denotes and
T6931 168-178 JJ denotes subsequent
T6932 179-197 NN denotes cytokine/chemokine
T6933 198-208 NN denotes expression
T6934 209-211 VBZ denotes is
T6935 212-215 RB denotes not
T6936 216-221 RB denotes fully
T6937 222-232 VBN denotes understood
T6938 232-233 . denotes .
T6939 234-237 DT denotes The
T6940 238-241 NN denotes aim
T6941 242-244 IN denotes of
T6942 245-248 DT denotes the
T6943 249-256 JJ denotes present
T6944 257-262 NN denotes study
T6945 263-266 VBD denotes was
T6946 267-269 TO denotes to
T6947 270-281 VB denotes investigate
T6948 282-286 NNP denotes IL-6
T6949 287-290 CC denotes and
T6950 291-296 NNP denotes CXCL8
T6951 297-307 NN denotes regulation
T6952 308-310 IN denotes by
T6953 311-316 NNP denotes NF-κB
T6954 317-320 CC denotes and
T6955 321-325 NNP denotes AP-1
T6956 326-328 IN denotes in
T6957 329-335 NNP denotes Jurkat
T6958 336-343 NNS denotes T-cells
T6959 343-344 . denotes .
T6960 345-348 PRP$ denotes Our
T6961 349-356 NNS denotes results
T6962 357-369 VBD denotes demonstrated
T6963 370-374 IN denotes that
T6964 375-378 NNP denotes PMA
T6965 379-386 VBD denotes induced
T6966 387-391 JJ denotes AP-1
T6967 392-402 NN denotes activation
T6968 402-403 , denotes ,
T6969 404-414 VBG denotes indicating
T6970 415-416 DT denotes a
T6971 417-425 JJ denotes specific
T6972 426-436 NN denotes activation
T6973 437-439 IN denotes of
T6974 440-443 DT denotes the
T6975 444-448 NNP denotes MAPK
T6976 449-456 NN denotes pathway
T6977 456-457 . denotes .
T6978 458-469 RB denotes Furthermore
T6979 469-470 , denotes ,
T6980 471-473 PRP denotes we
T6981 474-486 VBD denotes demonstrated
T6982 487-491 IN denotes that
T6983 492-495 NNP denotes PMA
T6984 496-505 JJ denotes dependent
T6985 506-510 NN denotes AP-1
T6986 511-521 NN denotes activation
T6987 522-524 IN denotes in
T6988 525-532 NNS denotes T-cells
T6989 533-536 VBD denotes was
T6990 537-544 VBN denotes delayed
T6991 545-546 -LRB- denotes (
T6992 546-547 CD denotes >
T6993 547-548 CD denotes 2
T6994 549-550 NN denotes h
T6995 550-551 -RRB- denotes )
T6996 552-555 CC denotes and
T6997 556-565 VBD denotes increased
T6998 566-575 VBG denotes following
T6999 576-585 JJ denotes long-term
T7000 586-595 NN denotes treatment
T7001 595-596 . denotes .
T7002 597-601 NNP denotes MAPK
T7003 602-604 VBZ denotes is
T7004 605-608 CD denotes one
T7005 609-611 IN denotes of
T7006 612-615 DT denotes the
T7007 616-620 JJ denotes main
T7008 621-631 JJ denotes signalling
T7009 632-640 NNS denotes pathways
T7010 641-643 IN denotes in
T7011 644-651 NNS denotes T-cells
T7012 652-656 WDT denotes that
T7013 657-665 VBP denotes regulate
T7014 666-670 NN denotes cell
T7015 670-671 : denotes -
T7016 672-675 CC denotes and
T7017 676-691 JJ denotes transcriptional
T7018 692-702 NN denotes activation
T7019 703-704 NNP denotes [
T7020 704-709 CD denotes 31,32
T7021 709-710 NNP denotes ]
T7022 710-711 . denotes .
T7023 712-719 JJ denotes Several
T7024 720-727 NNS denotes studies
T7025 728-729 NNP denotes [
T7026 729-737 CD denotes 20,33,34
T7027 737-738 NNP denotes ]
T7028 739-743 VBP denotes have
T7029 744-753 VBN denotes indicated
T7030 754-757 DT denotes the
T7031 758-768 NN denotes importance
T7032 769-771 IN denotes of
T7033 772-776 NN denotes AP-1
T7034 777-779 IN denotes in
T7035 780-786 NNP denotes T-cell
T7036 787-797 NN denotes activation
T7037 798-801 CC denotes and
T7038 802-805 DT denotes the
T7039 806-815 NN denotes induction
T7040 816-818 IN denotes of
T7041 819-831 JJ denotes inflammatory
T7042 832-841 NNS denotes responses
T7043 842-843 NNP denotes [
T7044 843-845 CD denotes 35
T7045 845-846 NNP denotes ]
T7046 846-847 , denotes ,
T7047 848-857 VBG denotes including
T7048 858-874 JJ denotes pro-inflammatory
T7049 875-883 NN denotes cytokine
T7050 884-891 NN denotes release
T7051 891-892 . denotes .
T7052 893-895 IN denotes In
T7053 896-904 NN denotes contrast
T7054 905-907 TO denotes to
T7055 908-912 NNP denotes AP-1
T7056 912-913 , denotes ,
T7057 914-919 JJ denotes NF-κB
T7058 920-928 NN denotes activity
T7059 929-936 RB denotes rapidly
T7060 937-946 VBD denotes increased
T7061 947-948 -LRB- denotes (
T7062 948-949 CD denotes 1
T7063 950-953 NN denotes min
T7064 953-954 -RRB- denotes )
T7065 955-961 IN denotes during
T7066 962-965 NNP denotes PMA
T7067 966-974 NN denotes exposure
T7068 975-983 VBN denotes followed
T7069 984-986 IN denotes by
T7070 987-988 DT denotes a
T7071 989-1004 NN denotes down-regulation
T7072 1005-1007 TO denotes to
T7073 1008-1011 DT denotes the
T7074 1012-1018 JJS denotes lowest
T7075 1019-1025 NNS denotes levels
T7076 1026-1028 IN denotes at
T7077 1029-1030 CD denotes 6
T7078 1031-1032 NN denotes h
T7079 1032-1033 . denotes .
T7080 1034-1038 DT denotes This
T7081 1039-1041 VBZ denotes is
T7082 1042-1044 IN denotes in
T7083 1045-1049 NN denotes line
T7084 1050-1054 IN denotes with
T7085 1055-1059 NNP denotes Park
T7086 1060-1063 CC denotes and
T7087 1064-1074 NNS denotes colleagues
T7088 1075-1076 NNP denotes [
T7089 1076-1078 CD denotes 36
T7090 1078-1079 NNP denotes ]
T7091 1080-1083 WP denotes who
T7092 1084-1096 VBD denotes demonstrated
T7093 1097-1098 DT denotes a
T7094 1099-1104 JJ denotes rapid
T7095 1105-1113 NN denotes increase
T7096 1114-1116 IN denotes in
T7097 1117-1122 JJ denotes NF-κB
T7098 1123-1131 NN denotes activity
T7099 1132-1141 VBG denotes following
T7100 1142-1152 JJ denotes short-term
T7101 1153-1164 NN denotes stimulation
T7102 1165-1169 IN denotes with
T7103 1170-1173 NNP denotes PMA
T7104 1173-1174 , denotes ,
T7105 1175-1178 CC denotes but
T7106 1179-1188 VBN denotes prolonged
T7107 1189-1198 NN denotes challenge
T7108 1199-1207 VBD denotes resulted
T7109 1208-1210 IN denotes in
T7110 1211-1212 DT denotes a
T7111 1213-1223 JJ denotes persistent
T7112 1224-1234 NN denotes inhibition
T7113 1235-1237 IN denotes of
T7114 1238-1243 NN denotes NF-κB
T7115 1243-1244 . denotes .
T7116 1245-1249 PRP denotes They
T7117 1250-1256 VBD denotes showed
T7118 1257-1261 IN denotes that
T7119 1262-1265 DT denotes the
T7120 1266-1276 NN denotes inhibition
T7121 1277-1279 IN denotes of
T7122 1280-1285 NN denotes NF-κB
T7123 1286-1289 VBD denotes was
T7124 1290-1293 JJ denotes due
T7125 1294-1296 TO denotes to
T7126 1297-1310 JJ denotes PKC-dependent
T7127 1311-1322 NN denotes degradation
T7128 1323-1325 IN denotes of
T7129 1326-1329 NNP denotes IκB
T7130 1330-1336 NN denotes kinase
T7131 1337-1338 NN denotes β
T7132 1339-1342 CC denotes and
T7133 1343-1344 NN denotes γ
T7134 1345-1347 IN denotes in
T7135 1348-1356 NN denotes response
T7136 1357-1359 TO denotes to
T7137 1360-1363 NNP denotes PMA
T7138 1363-1364 . denotes .
T7139 1365-1378 RB denotes Interestingly
T7140 1378-1379 , denotes ,
T7141 1380-1383 DT denotes the
T7142 1384-1386 NNP denotes HK
T7143 1387-1389 NNP denotes E.
T7144 1390-1394 NNS denotes coli
T7145 1395-1403 NN denotes exposure
T7146 1404-1411 VBD denotes induced
T7147 1412-1417 JJ denotes NF-κB
T7148 1418-1428 NN denotes activation
T7149 1429-1436 IN denotes without
T7150 1437-1446 VBG denotes affecting
T7151 1447-1451 JJ denotes AP-1
T7152 1452-1460 NN denotes activity
T7153 1460-1461 . denotes .
T7154 1462-1466 NNP denotes Wang
T7155 1467-1470 CC denotes and
T7156 1471-1481 NNS denotes colleagues
T7157 1482-1483 NNP denotes [
T7158 1483-1485 CD denotes 37
T7159 1485-1486 NNP denotes ]
T7160 1487-1495 VBD denotes reported
T7161 1496-1498 DT denotes an
T7162 1499-1507 JJ denotes elevated
T7163 1508-1520 JJ denotes inflammatory
T7164 1521-1529 NN denotes response
T7165 1530-1532 IN denotes by
T7166 1533-1542 VBG denotes obtaining
T7167 1543-1553 NN denotes expression
T7168 1554-1556 IN denotes of
T7169 1557-1561 NN denotes IL-6
T7170 1562-1571 VBG denotes following
T7171 1572-1575 DT denotes the
T7172 1576-1584 NN denotes exposure
T7173 1585-1587 IN denotes of
T7174 1588-1595 NNS denotes T-cells
T7175 1596-1598 TO denotes to
T7176 1599-1612 JJ denotes peptidoglycan
T7177 1612-1613 . denotes .
T7178 1614-1623 NN denotes Reduction
T7179 1624-1626 IN denotes in
T7180 1627-1632 NN denotes NF-κB
T7181 1633-1635 IN denotes by
T7182 1636-1643 NN denotes calcium
T7183 1644-1653 NN denotes ionophore
T7184 1654-1663 VBG denotes following
T7185 1664-1666 NNP denotes HK
T7186 1667-1669 NNP denotes E.
T7187 1670-1674 NNS denotes coli
T7188 1675-1686 NN denotes stimulation
T7189 1687-1690 MD denotes may
T7190 1691-1693 VB denotes be
T7191 1694-1697 JJ denotes due
T7192 1698-1700 TO denotes to
T7193 1701-1704 DT denotes the
T7194 1705-1708 NNP denotes Ca2
T7195 1708-1709 NN denotes +
T7196 1710-1717 JJ denotes binding
T7197 1718-1725 NN denotes protein
T7198 1726-1736 NN denotes calmodulin
T7199 1737-1738 -LRB- denotes (
T7200 1738-1741 NNP denotes CaM
T7201 1741-1742 -RRB- denotes )
T7202 1742-1743 , denotes ,
T7203 1744-1749 WDT denotes which
T7204 1750-1753 VBZ denotes has
T7205 1754-1758 VBN denotes been
T7206 1759-1764 VBN denotes shown
T7207 1765-1767 TO denotes to
T7208 1768-1778 RB denotes negatively
T7209 1779-1787 VB denotes regulate
T7210 1788-1793 JJ denotes c-Rel
T7211 1794-1798 WRB denotes when
T7212 1799-1808 VBN denotes activated
T7213 1809-1810 NNP denotes [
T7214 1810-1812 CD denotes 38
T7215 1812-1813 NNP denotes ]
T7216 1813-1814 . denotes .
T7217 1815-1818 DT denotes The
T7218 1819-1829 NN denotes regulation
T7219 1830-1832 IN denotes of
T7220 1833-1838 NNP denotes NF-κB
T7221 1839-1842 CC denotes and
T7222 1843-1847 NNP denotes AP-1
T7223 1848-1856 VBD denotes observed
T7224 1857-1859 IN denotes in
T7225 1860-1863 DT denotes the
T7226 1864-1871 JJ denotes present
T7227 1872-1877 NN denotes study
T7228 1878-1881 VBD denotes was
T7229 1882-1884 IN denotes in
T7230 1885-1894 NN denotes agreement
T7231 1895-1899 IN denotes with
T7232 1900-1907 JJR denotes earlier
T7233 1908-1915 NNS denotes studies
T7234 1915-1916 . denotes .
T7235 1917-1924 NNS denotes T-cells
T7236 1925-1932 VBP denotes produce
T7237 1933-1934 DT denotes a
T7238 1935-1940 JJ denotes broad
T7239 1941-1946 NN denotes range
T7240 1947-1949 IN denotes of
T7241 1950-1954 JJ denotes pro-
T7242 1955-1958 CC denotes and
T7243 1959-1976 JJ denotes anti-inflammatory
T7244 1977-1986 NNS denotes cytokines
T7245 1986-1987 , denotes ,
T7246 1988-1997 VBG denotes including
T7247 1998-2002 NNP denotes IL-2
T7248 2002-2003 , denotes ,
T7249 2004-2008 NNP denotes IL-6
T7250 2008-2009 , denotes ,
T7251 2010-2015 NNP denotes CXCL8
T7252 2015-2016 , denotes ,
T7253 2017-2020 NNP denotes TNF
T7254 2021-2024 CC denotes and
T7255 2025-2030 NNP denotes IL-10
T7256 2030-2031 , denotes ,
T7257 2032-2034 IN denotes in
T7258 2035-2043 NN denotes response
T7259 2044-2046 TO denotes to
T7260 2047-2057 NNS denotes infections
T7261 2058-2060 CC denotes or
T7262 2061-2066 JJ denotes other
T7263 2067-2073 NN denotes stress
T7264 2074-2081 NNS denotes factors
T7265 2082-2083 NNP denotes [
T7266 2083-2085 CD denotes 39
T7267 2085-2086 NNP denotes ]
T7268 2086-2087 . denotes .
T7269 2088-2091 DT denotes The
T7270 2092-2102 NN denotes assessment
T7271 2103-2105 IN denotes of
T7272 2106-2112 NNP denotes Jurkat
T7273 2113-2119 NNP denotes T-cell
T7274 2120-2132 JJ denotes inflammatory
T7275 2133-2142 NNS denotes responses
T7276 2143-2144 -LRB- denotes (
T7277 2144-2149 NNP denotes Table
T7278 2150-2151 CD denotes 1
T7279 2151-2152 -RRB- denotes )
T7280 2153-2161 VBD denotes revealed
T7281 2162-2164 DT denotes an
T7282 2165-2173 JJ denotes enhanced
T7283 2174-2178 NN denotes IL-2
T7284 2179-2189 NN denotes expression
T7285 2190-2194 IN denotes upon
T7286 2195-2203 NN denotes exposure
T7287 2204-2206 TO denotes to
T7288 2207-2210 NNP denotes PMA
T7289 2211-2213 CC denotes or
T7290 2214-2216 NNP denotes HK
T7291 2217-2219 NNP denotes E.
T7292 2220-2224 NNS denotes coli
T7293 2225-2228 JJ denotes due
T7294 2229-2231 TO denotes to
T7295 2232-2235 NNP denotes PKC
T7296 2236-2246 NN denotes activation
T7297 2247-2248 NNP denotes [
T7298 2248-2250 CD denotes 40
T7299 2250-2251 NNP denotes ]
T7300 2251-2252 . denotes .
T7301 2253-2255 IN denotes In
T7302 2256-2264 NN denotes addition
T7303 2265-2267 TO denotes to
T7304 2268-2271 DT denotes the
T7305 2272-2285 NN denotes transcription
T7306 2286-2292 NN denotes factor
T7307 2293-2298 NNP denotes NF-κB
T7308 2298-2299 , denotes ,
T7309 2300-2304 NNP denotes AP-1
T7310 2305-2312 JJ denotes binding
T7311 2313-2318 NNS denotes sites
T7312 2319-2323 VBP denotes have
T7313 2324-2328 VBN denotes been
T7314 2329-2339 VBN denotes identified
T7315 2340-2342 IN denotes in
T7316 2343-2346 DT denotes the
T7317 2347-2351 NNP denotes IL-6
T7318 2352-2360 NN denotes promoter
T7319 2361-2367 NN denotes region
T7320 2367-2368 , denotes ,
T7321 2369-2379 VBG denotes indicating
T7322 2380-2388 JJ denotes multiple
T7323 2389-2399 NN denotes regulation
T7324 2400-2401 NNP denotes [
T7325 2401-2403 CD denotes 22
T7326 2403-2404 NNP denotes ]
T7327 2404-2405 . denotes .
T7328 2406-2410 CD denotes AP-1
T7329 2411-2414 CC denotes and
T7330 2415-2420 NNP denotes NF-κB
T7331 2421-2425 VBP denotes have
T7332 2426-2430 RB denotes also
T7333 2431-2435 VBN denotes been
T7334 2436-2448 VBN denotes demonstrated
T7335 2449-2451 TO denotes to
T7336 2452-2460 VB denotes regulate
T7337 2461-2466 NNP denotes CXCL8
T7338 2467-2477 NN denotes expression
T7339 2478-2484 IN denotes during
T7340 2485-2494 NN denotes induction
T7341 2495-2497 IN denotes of
T7342 2498-2510 JJ denotes inflammatory
T7343 2511-2520 NNS denotes responses
T7344 2521-2523 IN denotes in
T7345 2524-2531 NNS denotes T-cells
T7346 2532-2533 NNP denotes [
T7347 2533-2535 CD denotes 12
T7348 2535-2536 NNP denotes ]
T7349 2536-2537 . denotes .
T7350 2538-2549 RB denotes Furthermore
T7351 2549-2550 , denotes ,
T7352 2551-2555 NNP denotes IL-6
T7353 2556-2559 CC denotes and
T7354 2560-2565 NNP denotes CXCL8
T7355 2566-2581 NN denotes gene-expression
T7356 2582-2584 VBZ denotes is
T7357 2585-2595 VBN denotes associated
T7358 2596-2600 IN denotes with
T7359 2601-2603 DT denotes an
T7360 2604-2609 JJ denotes early
T7361 2610-2616 JJ denotes immune
T7362 2617-2625 NN denotes response
T7363 2626-2628 IN denotes in
T7364 2629-2635 NNP denotes Jurkat
T7365 2636-2643 NNS denotes T-cells
T7366 2644-2645 NNP denotes [
T7367 2645-2647 CD denotes 41
T7368 2647-2648 NNP denotes ]
T7369 2648-2649 . denotes .
T7370 2650-2652 IN denotes In
T7371 2653-2656 DT denotes the
T7372 2657-2664 JJ denotes present
T7373 2665-2670 NN denotes study
T7374 2670-2671 , denotes ,
T7375 2672-2676 DT denotes both
T7376 2677-2680 NNP denotes PMA
T7377 2681-2684 CC denotes and
T7378 2685-2687 NNP denotes HK
T7379 2688-2690 NNP denotes E.
T7380 2691-2695 NNS denotes coli
T7381 2696-2704 VBD denotes resulted
T7382 2705-2707 IN denotes in
T7383 2708-2718 JJ denotes comparable
T7384 2719-2728 NNS denotes increases
T7385 2729-2731 IN denotes in
T7386 2732-2736 NN denotes IL-6
T7387 2737-2742 IN denotes while
T7388 2743-2746 NNP denotes PMA
T7389 2747-2750 VBD denotes was
T7390 2751-2755 RBR denotes more
T7391 2756-2762 JJ denotes potent
T7392 2763-2765 IN denotes at
T7393 2766-2776 VBG denotes activating
T7394 2777-2782 NNP denotes CXCL8
T7395 2783-2790 NN denotes release
T7396 2790-2791 . denotes .
T7397 2792-2795 NNP denotes PMA
T7398 2796-2799 CC denotes and
T7399 2800-2802 NNP denotes HK
T7400 2803-2805 NNP denotes E.
T7401 2806-2810 NNS denotes coli
T7402 2811-2820 NN denotes treatment
T7403 2821-2825 RB denotes also
T7404 2826-2833 VBD denotes induced
T7405 2834-2837 NNP denotes TNF
T7406 2838-2848 NN denotes expression
T7407 2848-2849 . denotes .
T7408 2850-2853 NNP denotes TNF
T7409 2854-2856 VBZ denotes is
T7410 2857-2860 CD denotes one
T7411 2861-2863 IN denotes of
T7412 2864-2867 DT denotes the
T7413 2868-2873 JJ denotes first
T7414 2874-2883 NNS denotes cytokines
T7415 2884-2891 VBN denotes induced
T7416 2892-2894 IN denotes by
T7417 2895-2902 NNS denotes T-cells
T7418 2903-2904 NNP denotes [
T7419 2904-2906 CD denotes 42
T7420 2906-2907 NNP denotes ]
T7421 2908-2911 CC denotes and
T7422 2912-2915 PRP$ denotes its
T7423 2916-2926 NN denotes expression
T7424 2927-2929 VBZ denotes is
T7425 2930-2939 VBN denotes regulated
T7426 2940-2942 IN denotes by
T7427 2943-2954 NN denotes calcineurin
T7428 2954-2955 , denotes ,
T7429 2956-2960 NNP denotes NFAT
T7430 2961-2964 CC denotes and
T7431 2965-2970 NNP denotes ATF-2
T7432 2970-2971 NNP denotes /
T7433 2971-2974 NNP denotes Jun
T7434 2975-2976 NNP denotes [
T7435 2976-2978 CD denotes 20
T7436 2978-2979 NNP denotes ]
T7437 2979-2980 . denotes .
T7438 2981-2988 RB denotes However
T7439 2988-2989 , denotes ,
T7440 2990-3004 JJ denotes PMA-stimulated
T7441 3005-3011 NNP denotes Jurkat
T7442 3012-3019 NNS denotes T-cells
T7443 3020-3026 VBD denotes showed
T7444 3027-3029 DT denotes no
T7445 3030-3040 NN denotes difference
T7446 3041-3043 IN denotes in
T7447 3044-3049 NNP denotes IL-10
T7448 3050-3060 NN denotes expression
T7449 3061-3071 VBG denotes indicating
T7450 3072-3074 DT denotes an
T7451 3075-3082 JJ denotes induced
T7452 3083-3095 JJ denotes inflammatory
T7453 3096-3104 NN denotes response
T7454 3104-3105 . denotes .
T7455 3106-3108 NNP denotes HK
T7456 3109-3111 NNP denotes E.
T7457 3112-3116 NNS denotes coli
T7458 3117-3126 NN denotes treatment
T7459 3127-3135 VBD denotes resulted
T7460 3136-3138 IN denotes in
T7461 3139-3140 DT denotes a
T7462 3141-3152 JJ denotes significant
T7463 3153-3162 NN denotes reduction
T7464 3163-3165 IN denotes of
T7465 3166-3171 NNP denotes IL-10
T7466 3172-3182 NN denotes expression
T7467 3182-3183 . denotes .
T7468 3184-3187 DT denotes The
T7469 3188-3205 JJ denotes anti-inflammatory
T7470 3206-3214 NN denotes cytokine
T7471 3215-3220 NN denotes IL-10
T7472 3221-3223 VBZ denotes is
T7473 3224-3229 VBN denotes known
T7474 3230-3232 TO denotes to
T7475 3233-3240 VB denotes inhibit
T7476 3241-3247 NNP denotes T-cell
T7477 3248-3258 NN denotes activation
T7478 3258-3259 , denotes ,
T7479 3260-3273 NN denotes proliferation
T7480 3274-3277 CC denotes and
T7481 3278-3281 DT denotes the
T7482 3282-3292 NN denotes expression
T7483 3293-3295 IN denotes of
T7484 3296-3312 JJ denotes pro-inflammatory
T7485 3313-3322 NNS denotes cytokines
T7486 3322-3323 , denotes ,
T7487 3324-3328 JJ denotes such
T7488 3329-3331 IN denotes as
T7489 3332-3336 NNP denotes IL-2
T7490 3336-3337 , denotes ,
T7491 3338-3342 NNP denotes IL-5
T7492 3343-3346 CC denotes and
T7493 3347-3352 NNP denotes INF-γ
T7494 3353-3354 NNP denotes [
T7495 3354-3359 CD denotes 39,43
T7496 3359-3360 NNP denotes ]
T7497 3361-3364 CC denotes and
T7498 3365-3373 VB denotes regulate
T7499 3374-3386 JJ denotes inflammatory
T7500 3387-3396 NNS denotes responses
T7501 3397-3399 IN denotes by
T7502 3400-3408 VBG denotes inducing
T7503 3409-3415 NNP denotes T-cell
T7504 3416-3422 NN denotes anergy
T7505 3423-3424 NNP denotes [
T7506 3424-3426 CD denotes 44
T7507 3426-3427 NNP denotes ]
T7508 3427-3428 . denotes .
T7509 3429-3432 DT denotes The
T7510 3433-3437 NN denotes time
T7511 3438-3444 NN denotes course
T7512 3445-3453 NN denotes analysis
T7513 3454-3456 IN denotes of
T7514 3457-3465 NN denotes cytokine
T7515 3466-3476 NN denotes expression
T7516 3477-3483 VBD denotes showed
T7517 3484-3485 DT denotes a
T7518 3486-3497 NN denotes correlation
T7519 3498-3505 IN denotes between
T7520 3506-3510 NNP denotes AP-1
T7521 3511-3514 CC denotes and
T7522 3515-3518 DT denotes the
T7523 3519-3528 NN denotes chemokine
T7524 3529-3534 CD denotes CXCL8
T7525 3535-3540 WRB denotes where
T7526 3541-3546 NNP denotes CXCL8
T7527 3547-3557 NN denotes expression
T7528 3558-3561 VBD denotes was
T7529 3562-3575 RB denotes significantly
T7530 3576-3584 JJ denotes elevated
T7531 3585-3592 RB denotes already
T7532 3593-3595 IN denotes at
T7533 3596-3599 CD denotes 2-6
T7534 3600-3601 NN denotes h
T7535 3602-3607 IN denotes after
T7536 3608-3611 NNP denotes PMA
T7537 3612-3620 NN denotes exposure
T7538 3620-3621 . denotes .
T7539 3622-3625 DT denotes The
T7540 3626-3631 NNP denotes CXCL8
T7541 3632-3642 NN denotes expression
T7542 3643-3646 VBD denotes did
T7543 3647-3650 RB denotes not
T7544 3651-3660 VB denotes correlate
T7545 3661-3665 IN denotes with
T7546 3666-3669 DT denotes the
T7547 3670-3675 JJ denotes early
T7548 3676-3681 NN denotes NF-κB
T7549 3682-3692 NN denotes activation
T7550 3693-3694 -LRB- denotes (
T7551 3694-3695 CD denotes 1
T7552 3696-3699 NN denotes min
T7553 3699-3700 -RRB- denotes )
T7554 3701-3703 CC denotes or
T7555 3704-3708 IN denotes with
T7556 3709-3712 DT denotes the
T7557 3713-3728 NN denotes down-regulation
T7558 3729-3731 IN denotes of
T7559 3732-3737 NN denotes NF-κB
T7560 3738-3740 IN denotes at
T7561 3741-3742 CD denotes 2
T7562 3743-3744 NN denotes h
T7563 3745-3749 NN denotes post
T7564 3750-3758 NN denotes exposure
T7565 3758-3759 . denotes .
T7566 3760-3764 DT denotes Both
T7567 3765-3769 NNP denotes IL-6
T7568 3770-3773 CC denotes and
T7569 3774-3777 NNP denotes TNF
T7570 3778-3788 NN denotes expression
T7571 3789-3793 VBD denotes were
T7572 3794-3796 RB denotes up
T7573 3797-3806 VBN denotes regulated
T7574 3807-3814 IN denotes between
T7575 3815-3819 CD denotes 6-24
T7576 3820-3821 NN denotes h
T7577 3821-3822 . denotes .
T7578 3823-3829 IN denotes During
T7579 3830-3834 DT denotes this
T7580 3835-3841 NN denotes period
T7581 3841-3842 , denotes ,
T7582 3843-3848 NNP denotes NF-κB
T7583 3849-3858 VBD denotes increased
T7584 3859-3863 IN denotes from
T7585 3864-3867 PRP$ denotes its
T7586 3868-3875 JJ denotes minimum
T7587 3876-3881 NN denotes level
T7588 3882-3884 IN denotes at
T7589 3885-3886 CD denotes 6
T7590 3887-3889 NN denotes h.
T7591 3890-3893 NNP denotes PKC
T7592 3894-3897 VBZ denotes has
T7593 3898-3902 VBN denotes been
T7594 3903-3908 VBN denotes shown
T7595 3909-3911 TO denotes to
T7596 3912-3914 VB denotes be
T7597 3915-3925 VBN denotes associated
T7598 3926-3930 IN denotes with
T7599 3931-3934 DT denotes the
T7600 3935-3945 NN denotes activation
T7601 3946-3948 IN denotes of
T7602 3949-3953 NNP denotes AP-1
T7603 3953-3954 , denotes ,
T7604 3955-3958 CC denotes but
T7605 3959-3962 RB denotes not
T7606 3963-3967 IN denotes with
T7607 3968-3973 JJ denotes NF-κB
T7608 3974-3984 NN denotes activation
T7609 3985-3987 IN denotes of
T7610 3988-3991 DT denotes the
T7611 3992-3996 NN denotes IL-2
T7612 3997-4005 NN denotes promoter
T7613 4006-4007 NNP denotes [
T7614 4007-4009 CD denotes 45
T7615 4009-4010 NNP denotes ]
T7616 4010-4011 . denotes .
T7617 4012-4020 NN denotes Mutation
T7618 4021-4023 IN denotes of
T7619 4024-4027 DT denotes the
T7620 4028-4033 NNP denotes NF-κB
T7621 4034-4038 NN denotes site
T7622 4039-4042 VBD denotes did
T7623 4043-4046 RB denotes not
T7624 4047-4053 VB denotes affect
T7625 4054-4058 JJ denotes IL-2
T7626 4059-4069 NN denotes expression
T7627 4069-4070 , denotes ,
T7628 4071-4078 IN denotes whereas
T7629 4079-4087 NN denotes mutation
T7630 4088-4090 IN denotes of
T7631 4091-4094 DT denotes the
T7632 4095-4099 NNP denotes AP-1
T7633 4100-4104 NN denotes site
T7634 4105-4107 CC denotes or
T7635 4108-4111 NNP denotes PKC
T7636 4112-4121 NN denotes depletion
T7637 4122-4128 RB denotes almost
T7638 4129-4136 VBN denotes revoked
T7639 4137-4141 NN denotes IL-2
T7640 4142-4149 NN denotes release
T7641 4149-4150 . denotes .
T7642 4151-4156 DT denotes These
T7643 4157-4169 NNS denotes observations
T7644 4170-4178 VBP denotes indicate
T7645 4179-4183 IN denotes that
T7646 4184-4187 DT denotes the
T7647 4188-4192 NNP denotes MAPK
T7648 4193-4200 NN denotes pathway
T7649 4201-4204 CC denotes and
T7650 4205-4208 DT denotes the
T7651 4209-4222 NN denotes transcription
T7652 4223-4229 NN denotes factor
T7653 4230-4234 NNP denotes AP-1
T7654 4235-4239 VB denotes play
T7655 4240-4242 DT denotes an
T7656 4243-4252 JJ denotes important
T7657 4253-4257 NN denotes role
T7658 4258-4260 IN denotes in
T7659 4261-4264 DT denotes the
T7660 4265-4274 NN denotes induction
T7661 4275-4277 IN denotes of
T7662 4278-4290 JJ denotes inflammatory
T7663 4291-4300 NNS denotes responses
T7664 4301-4303 IN denotes in
T7665 4304-4310 NNP denotes Jurkat
T7666 4311-4318 NNS denotes T-cells
T7667 4319-4320 NNP denotes [
T7668 4320-4328 CD denotes 12,20,22
T7669 4328-4329 NNP denotes ]
T7670 4329-4330 . denotes .
T7671 4331-4334 DT denotes The
T7672 4335-4343 VBN denotes obtained
T7673 4344-4351 NNS denotes results
T7674 4352-4359 VBP denotes signify
T7675 4360-4364 IN denotes that
T7676 4365-4370 CD denotes CXCL8
T7677 4371-4374 VBD denotes was
T7678 4375-4384 RB denotes primarily
T7679 4385-4394 VBN denotes regulated
T7680 4395-4402 IN denotes through
T7681 4403-4406 DT denotes the
T7682 4407-4411 NNP denotes MAPK
T7683 4412-4419 NN denotes pathway
T7684 4419-4420 . denotes .
T7685 4421-4424 DT denotes The
T7686 4425-4430 JJ denotes NF-κB
T7687 4431-4441 NN denotes activation
T7688 4442-4451 NN denotes inhibitor
T7689 4452-4453 -LRB- denotes (
T7690 4453-4456 NNP denotes NAI
T7691 4456-4457 -RRB- denotes )
T7692 4458-4464 VBD denotes showed
T7693 4465-4476 NN denotes specificity
T7694 4477-4484 IN denotes against
T7695 4485-4490 NNP denotes NF-κB
T7696 4491-4494 CC denotes and
T7697 4495-4503 VBD denotes resulted
T7698 4504-4506 IN denotes in
T7699 4507-4508 DT denotes a
T7700 4509-4517 JJ denotes complete
T7701 4518-4522 NN denotes IL-6
T7702 4523-4533 NN denotes inhibition
T7703 4534-4543 VBG denotes following
T7704 4544-4553 NN denotes induction
T7705 4554-4558 IN denotes with
T7706 4559-4562 NNP denotes PMA
T7707 4563-4566 CC denotes and
T7708 4567-4578 JJ denotes significant
T7709 4579-4583 NN denotes IL-6
T7710 4584-4593 NN denotes reduction
T7711 4594-4599 IN denotes after
T7712 4600-4602 NNP denotes HK
T7713 4603-4605 NNP denotes E.
T7714 4606-4610 NNS denotes coli
T7715 4611-4620 NN denotes treatment
T7716 4620-4621 . denotes .
T7717 4622-4627 CD denotes CXCL8
T7718 4628-4631 VBD denotes was
T7719 4632-4638 RB denotes highly
T7720 4639-4641 RB denotes up
T7721 4642-4651 VBN denotes regulated
T7722 4652-4654 IN denotes by
T7723 4655-4658 NNP denotes PMA
T7724 4659-4662 CC denotes and
T7725 4663-4666 DT denotes the
T7726 4667-4675 NN denotes addition
T7727 4676-4678 IN denotes of
T7728 4679-4682 NNP denotes NAI
T7729 4683-4691 VBD denotes resulted
T7730 4692-4694 IN denotes in
T7731 4695-4696 DT denotes a
T7732 4697-4702 JJ denotes minor
T7733 4703-4712 NN denotes reduction
T7734 4713-4715 IN denotes in
T7735 4716-4721 CD denotes CXCL8
T7736 4722-4732 NN denotes expression
T7737 4732-4733 . denotes .
T7738 4734-4745 RB denotes Furthermore
T7739 4745-4746 , denotes ,
T7740 4747-4752 NNP denotes CXCL8
T7741 4753-4763 NN denotes expression
T7742 4764-4767 VBD denotes was
T7743 4768-4771 RB denotes not
T7744 4772-4780 VBN denotes affected
T7745 4781-4783 IN denotes by
T7746 4784-4787 NNP denotes NAI
T7747 4788-4797 VBG denotes following
T7748 4798-4800 NNP denotes HK
T7749 4801-4803 NNP denotes E.
T7750 4804-4808 NNS denotes coli
T7751 4809-4818 NN denotes treatment
T7752 4818-4819 , denotes ,
T7753 4820-4830 VBG denotes indicating
T7754 4831-4832 DT denotes a
T7755 4833-4837 NN denotes lack
T7756 4838-4840 IN denotes of
T7757 4841-4852 NN denotes correlation
T7758 4853-4860 IN denotes between
T7759 4861-4866 CD denotes CXCL8
T7760 4867-4870 CC denotes and
T7761 4871-4876 NNP denotes NF-κB
T7762 4876-4877 . denotes .
T7763 4878-4885 JJ denotes Further
T7764 4886-4894 NN denotes analysis
T7765 4895-4897 IN denotes of
T7766 4898-4903 CD denotes CXCL8
T7767 4904-4914 NN denotes expression
T7768 4915-4923 VBD denotes revealed
T7769 4924-4925 DT denotes a
T7770 4926-4941 NN denotes down-regulation
T7771 4942-4944 IN denotes by
T7772 4945-4948 NNP denotes PKC
T7773 4948-4949 : denotes -
T7774 4950-4953 CC denotes and
T7775 4954-4957 NNP denotes JNK
T7776 4957-4958 : denotes -
T7777 4959-4969 NNS denotes inhibitors
T7778 4969-4970 , denotes ,
T7779 4971-4981 VBG denotes suggesting
T7780 4982-4984 DT denotes an
T7781 4985-4996 NN denotes involvement
T7782 4997-4999 IN denotes of
T7783 5000-5004 NNP denotes AP-1
T7784 5005-5008 IN denotes via
T7785 5009-5012 NNP denotes PKC
T7786 5013-5016 CC denotes and
T7787 5017-5020 NNP denotes JNK
T7788 5020-5021 , denotes ,
T7789 5022-5034 RB denotes respectively
T7790 5034-5035 . denotes .
T7791 5036-5044 NN denotes Analysis
T7792 5045-5047 IN denotes of
T7793 5048-5052 NN denotes gene
T7794 5053-5063 NN denotes expression
T7795 5064-5071 JJ denotes further
T7796 5072-5081 VBD denotes confirmed
T7797 5082-5086 IN denotes that
T7798 5087-5091 JJ denotes il-6
T7799 5092-5095 CC denotes and
T7800 5096-5101 CD denotes cxcl8
T7801 5102-5106 VBD denotes were
T7802 5107-5118 VBN denotes upregulated
T7803 5119-5121 IN denotes by
T7804 5122-5125 NNP denotes PMA
T7805 5125-5126 . denotes .
T7806 5127-5137 NN denotes Expression
T7807 5138-5140 IN denotes of
T7808 5141-5145 JJ denotes il-6
T7809 5146-5153 VBD denotes dropped
T7810 5154-5159 IN denotes below
T7811 5160-5165 JJ denotes basal
T7812 5166-5172 NNS denotes levels
T7813 5173-5182 VBG denotes following
T7814 5183-5193 NN denotes inhibition
T7815 5194-5196 IN denotes of
T7816 5197-5202 NNP denotes NF-κB
T7817 5203-5206 CC denotes and
T7818 5207-5210 NNP denotes JNK
T7819 5211-5218 IN denotes whereas
T7820 5219-5224 CD denotes cxcl8
T7821 5225-5233 VBD denotes remained
T7822 5234-5242 JJ denotes elevated
T7823 5243-5248 IN denotes above
T7824 5249-5254 JJ denotes basal
T7825 5255-5261 NNS denotes levels
T7826 5262-5263 -LRB- denotes (
T7827 5263-5272 JJ denotes 16.5-fold
T7828 5273-5276 CC denotes and
T7829 5277-5285 JJ denotes 7.1-fold
T7830 5286-5298 RB denotes respectively
T7831 5298-5299 -RRB- denotes )
T7832 5300-5309 VBG denotes following
T7833 5310-5313 DT denotes the
T7834 5314-5318 JJ denotes same
T7835 5319-5328 NN denotes treatment
T7836 5328-5329 . denotes .
T7837 5330-5341 RB denotes Furthermore
T7838 5341-5342 , denotes ,
T7839 5343-5353 NN denotes inhibition
T7840 5354-5356 IN denotes of
T7841 5357-5360 NNP denotes PKC
T7842 5361-5364 VBD denotes did
T7843 5365-5368 RB denotes not
T7844 5369-5375 VB denotes result
T7845 5376-5378 IN denotes in
T7846 5379-5380 DT denotes a
T7847 5381-5392 JJ denotes significant
T7848 5393-5401 NN denotes decrease
T7849 5402-5404 IN denotes of
T7850 5405-5409 JJ denotes il-6
T7851 5410-5412 CC denotes or
T7852 5413-5418 JJ denotes cxcl8
T7853 5418-5419 , denotes ,
T7854 5420-5425 WDT denotes which
T7855 5426-5428 VBZ denotes is
T7856 5429-5431 IN denotes in
T7857 5432-5442 NN denotes accordance
T7858 5443-5447 IN denotes with
T7859 5448-5455 NN denotes protein
T7860 5456-5460 NNS denotes data
T7861 5461-5462 -LRB- denotes (
T7862 5462-5468 NN denotes figure
T7863 5469-5470 CD denotes 6
T7864 5470-5471 -RRB- denotes )
T7865 5471-5472 . denotes .
T7866 5473-5478 DT denotes These
T7867 5479-5486 NNS denotes results
T7868 5487-5494 VBP denotes suggest
T7869 5495-5499 IN denotes that
T7870 5500-5505 NNP denotes NF-κB
T7871 5506-5508 VBZ denotes is
T7872 5509-5517 VBN denotes involved
T7873 5518-5520 IN denotes in
T7874 5521-5525 NNP denotes IL-6
T7875 5526-5536 NN denotes regulation
T7876 5537-5540 CC denotes and
T7877 5541-5548 NN denotes release
T7878 5549-5554 IN denotes while
T7879 5555-5557 PRP denotes it
T7880 5558-5560 VBZ denotes is
T7881 5561-5564 RB denotes not
T7882 5565-5573 VBN denotes required
T7883 5574-5577 IN denotes for
T7884 5578-5581 DT denotes the
T7885 5582-5592 NN denotes expression
T7886 5593-5595 IN denotes of
T7887 5596-5601 CD denotes CXCL8
T7888 5602-5604 IN denotes in
T7889 5605-5611 NNP denotes Jurkat
T7890 5612-5613 NNP denotes T
T7891 5614-5619 NNS denotes cells
T7892 5619-5620 . denotes .
T7893 5621-5624 DT denotes The
T7894 5625-5638 NN denotes transcription
T7895 5639-5645 NN denotes factor
T7896 5646-5651 NN denotes NF-κB
T7897 5652-5654 VBZ denotes is
T7898 5655-5666 JJ denotes responsible
T7899 5667-5670 IN denotes for
T7900 5671-5672 DT denotes a
T7901 5673-5678 JJ denotes rapid
T7902 5679-5685 JJ denotes immune
T7903 5686-5694 NN denotes response
T7904 5695-5700 WDT denotes which
T7905 5701-5703 VBZ denotes is
T7906 5704-5712 VBN denotes followed
T7907 5713-5715 IN denotes by
T7908 5716-5718 DT denotes an
T7909 5719-5727 NN denotes increase
T7910 5728-5730 IN denotes in
T7911 5731-5744 NN denotes transcription
T7912 5745-5747 IN denotes of
T7913 5748-5751 NNP denotes IκB
T7914 5752-5756 RB denotes thus
T7915 5757-5767 VBG denotes inhibiting
T7916 5768-5773 NNP denotes NF-κB
T7917 5774-5775 NNP denotes [
T7918 5775-5777 CD denotes 46
T7919 5777-5778 NNP denotes ]
T7920 5778-5779 . denotes .
T7921 5780-5790 NNP denotes Activation
T7922 5791-5793 IN denotes of
T7923 5794-5799 NNP denotes NF-κB
T7924 5800-5802 IN denotes in
T7925 5803-5809 NNP denotes Jurkat
T7926 5810-5817 NNS denotes T-cells
T7927 5818-5820 VBZ denotes is
T7928 5821-5830 JJ denotes dependent
T7929 5831-5833 IN denotes on
T7930 5834-5839 JJ denotes Bcl10
T7931 5840-5850 NN denotes activation
T7932 5850-5851 , denotes ,
T7933 5852-5857 WDT denotes which
T7934 5858-5860 IN denotes in
T7935 5861-5865 NN denotes turn
T7936 5866-5868 VBZ denotes is
T7937 5869-5878 VBN denotes regulated
T7938 5879-5881 IN denotes by
T7939 5882-5885 NNP denotes PKC
T7940 5885-5886 . denotes .
T7941 5887-5893 JJ denotes Recent
T7942 5894-5901 NNS denotes studies
T7943 5902-5906 VBP denotes have
T7944 5907-5918 VBN denotes established
T7945 5919-5922 DT denotes the
T7946 5923-5933 NN denotes importance
T7947 5934-5936 IN denotes of
T7948 5937-5938 DT denotes a
T7949 5939-5946 NN denotes protein
T7950 5947-5954 JJ denotes complex
T7951 5955-5965 VBG denotes consisting
T7952 5966-5968 IN denotes of
T7953 5969-5975 NNP denotes CARMA1
T7954 5975-5976 , denotes ,
T7955 5977-5982 NNP denotes Bcl10
T7956 5983-5986 CC denotes and
T7957 5987-5992 NNP denotes MALT1
T7958 5993-5994 -LRB- denotes (
T7959 5994-5997 NNP denotes CBM
T7960 5997-5998 -RRB- denotes )
T7961 5998-5999 , denotes ,
T7962 6000-6002 IN denotes in
T7963 6003-6006 DT denotes the
T7964 6007-6016 NN denotes induction
T7965 6017-6019 IN denotes of
T7966 6020-6025 NN denotes NF-κB
T7967 6025-6026 . denotes .
T7968 6027-6040 VBG denotes Investigating
T7969 6041-6046 NNP denotes Bcl10
T7970 6046-6047 , denotes ,
T7971 6048-6060 NNP denotes Scharschmidt
T7972 6061-6064 CC denotes and
T7973 6065-6075 NNS denotes colleagues
T7974 6076-6077 NNP denotes [
T7975 6077-6079 CD denotes 47
T7976 6079-6080 NNP denotes ]
T7977 6081-6093 VBD denotes demonstrated
T7978 6094-6098 IN denotes that
T7979 6099-6101 PRP denotes it
T7980 6102-6104 VBZ denotes is
T7981 6105-6106 DT denotes a
T7982 6107-6115 JJ denotes critical
T7983 6116-6125 NN denotes regulator
T7984 6126-6128 IN denotes of
T7985 6129-6134 JJ denotes NF-κB
T7986 6135-6143 NN denotes activity
T7987 6143-6144 . denotes .
T7988 6145-6160 NN denotes Down-regulation
T7989 6161-6163 IN denotes of
T7990 6164-6169 NNP denotes Bcl10
T7991 6170-6174 IN denotes from
T7992 6175-6182 NNS denotes signals
T7993 6183-6193 VBN denotes transduced
T7994 6194-6197 IN denotes via
T7995 6198-6201 DT denotes the
T7996 6202-6210 CD denotes TCR/CD28
T7997 6211-6214 CC denotes and
T7998 6215-6218 NNP denotes PKC
T7999 6219-6227 VBD denotes resulted
T8000 6228-6230 IN denotes in
T8001 6231-6232 DT denotes a
T8002 6233-6244 JJ denotes concomitant
T8003 6245-6260 NN denotes down-regulation
T8004 6261-6263 IN denotes of
T8005 6264-6269 NN denotes NF-κB
T8006 6269-6270 . denotes .
T8007 6271-6275 PRP denotes They
T8008 6276-6285 VBD denotes suggested
T8009 6286-6290 IN denotes that
T8010 6291-6296 NNP denotes Bcl10
T8011 6297-6299 VBZ denotes is
T8012 6300-6309 RB denotes initially
T8013 6310-6319 VBN denotes activated
T8014 6320-6322 IN denotes by
T8015 6323-6330 NNP denotes TCR/PKC
T8016 6331-6334 CC denotes but
T8017 6335-6339 DT denotes that
T8018 6340-6349 VBD denotes continued
T8019 6350-6360 NN denotes activation
T8020 6361-6362 -LRB- denotes (
T8021 6362-6363 FW denotes >
T8022 6363-6364 CD denotes 1
T8023 6365-6366 NN denotes h
T8024 6366-6367 -RRB- denotes )
T8025 6368-6376 VBZ denotes promotes
T8026 6377-6380 PRP$ denotes its
T8027 6381-6392 NN denotes degradation
T8028 6392-6393 . denotes .
T8029 6394-6401 NNP denotes Narayan
T8030 6402-6405 CC denotes and
T8031 6406-6416 NNS denotes colleagues
T8032 6417-6418 NNP denotes [
T8033 6418-6420 CD denotes 27
T8034 6420-6421 NNP denotes ]
T8035 6422-6431 VBD denotes suggested
T8036 6432-6436 IN denotes that
T8037 6437-6445 NN denotes deletion
T8038 6446-6448 IN denotes in
T8039 6449-6452 DT denotes any
T8040 6453-6455 IN denotes of
T8041 6456-6459 DT denotes the
T8042 6460-6465 CD denotes three
T8043 6466-6469 NNP denotes CBM
T8044 6470-6477 JJ denotes complex
T8045 6478-6486 NNS denotes proteins
T8046 6487-6494 VBZ denotes impairs
T8047 6495-6511 JJ denotes antigen-receptor
T8048 6512-6521 JJ denotes dependent
T8049 6522-6532 NN denotes activation
T8050 6533-6535 IN denotes of
T8051 6536-6541 NN denotes NF-κB
T8052 6541-6542 . denotes .
T8053 6543-6547 PRP denotes They
T8054 6548-6554 VBD denotes showed
T8055 6555-6559 IN denotes that
T8056 6560-6565 JJ denotes NF-κB
T8057 6566-6576 NN denotes activation
T8058 6577-6580 IN denotes via
T8059 6581-6584 NNP denotes Akt
T8060 6585-6593 VBZ denotes requires
T8061 6594-6600 NNP denotes CARMA1
T8062 6601-6604 CC denotes and
T8063 6605-6609 NNS denotes acts
T8064 6610-6612 IN denotes in
T8065 6613-6624 NN denotes cooperation
T8066 6625-6629 IN denotes with
T8067 6630-6633 NNP denotes PKC
T8068 6634-6643 VBG denotes following
T8069 6644-6654 JJ denotes short-term
T8070 6655-6663 NN denotes exposure
T8071 6664-6665 -LRB- denotes (
T8072 6665-6667 CD denotes 30
T8073 6668-6671 NN denotes min
T8074 6671-6672 -RRB- denotes )
T8075 6673-6675 IN denotes of
T8076 6676-6682 NNP denotes Jurkat
T8077 6683-6690 NNS denotes T-cells
T8078 6691-6695 IN denotes with
T8079 6696-6699 NNP denotes PMA
T8080 6699-6700 . denotes .
T8081 6701-6704 NNP denotes Akt
T8082 6705-6719 NNS denotes phosphorylates
T8083 6720-6723 CC denotes and
T8084 6724-6728 RB denotes thus
T8085 6729-6738 VBZ denotes activates
T8086 6739-6744 NNP denotes Bcl10
T8087 6744-6745 . denotes .
T8088 6746-6751 DT denotes These
T8089 6752-6759 NNS denotes studies
T8090 6760-6768 VBP denotes indicate
T8091 6769-6773 IN denotes that
T8092 6774-6777 NNP denotes PKC
T8093 6778-6780 VBZ denotes is
T8094 6781-6788 JJ denotes crucial
T8095 6789-6792 IN denotes for
T8096 6793-6798 JJ denotes NF-κB
T8097 6799-6809 NN denotes activation
T8098 6810-6819 VBG denotes following
T8099 6820-6830 JJ denotes short-term
T8100 6831-6840 NN denotes treatment
T8101 6841-6848 IN denotes through
T8102 6849-6856 NNS denotes signals
T8103 6857-6860 IN denotes via
T8104 6861-6869 NN denotes membrane
T8105 6870-6875 VBN denotes bound
T8106 6876-6885 NNS denotes receptors
T8107 6886-6890 JJ denotes such
T8108 6891-6893 IN denotes as
T8109 6894-6897 DT denotes the
T8110 6898-6901 NNP denotes TCR
T8111 6902-6905 CC denotes and
T8112 6906-6909 DT denotes the
T8113 6910-6924 JJ denotes co-stimulatory
T8114 6925-6933 NN denotes receptor
T8115 6934-6938 NNP denotes CD28
T8116 6938-6939 . denotes .
T8117 6940-6944 RB denotes Thus
T8118 6944-6945 , denotes ,
T8119 6946-6949 DT denotes the
T8120 6950-6953 NNP denotes CBM
T8121 6954-6961 JJ denotes complex
T8122 6962-6970 NNS denotes proteins
T8123 6971-6975 VBP denotes play
T8124 6976-6977 DT denotes a
T8125 6978-6981 JJ denotes key
T8126 6982-6986 NN denotes role
T8127 6987-6989 IN denotes in
T8128 6990-6994 DT denotes this
T8129 6995-7005 JJ denotes signalling
T8130 7006-7013 NN denotes process
T8131 7013-7014 . denotes .
T8132 7015-7018 NNP denotes PMA
T8133 7019-7027 VBZ denotes diffuses
T8134 7028-7032 IN denotes into
T8135 7033-7036 DT denotes the
T8136 7037-7044 NN denotes cytosol
T8137 7045-7048 CC denotes and
T8138 7049-7057 RB denotes directly
T8139 7058-7067 VBZ denotes activates
T8140 7068-7071 NNP denotes PKC
T8141 7072-7077 IN denotes since
T8142 7078-7080 PRP denotes it
T8143 7081-7083 VBZ denotes is
T8144 7084-7086 DT denotes an
T8145 7087-7095 NN denotes analogue
T8146 7096-7098 TO denotes to
T8147 7099-7113 NN denotes diacylglycerol
T8148 7114-7115 NNP denotes [
T8149 7115-7117 CD denotes 48
T8150 7117-7118 NNP denotes ]
T8151 7118-7119 . denotes .
T8152 7120-7127 JJ denotes Several
T8153 7128-7135 NNS denotes studies
T8154 7136-7140 VBP denotes have
T8155 7141-7153 VBN denotes demonstrated
T8156 7154-7158 IN denotes that
T8157 7159-7169 NN denotes inhibition
T8158 7170-7172 IN denotes of
T8159 7173-7176 NNP denotes PKC
T8160 7177-7183 NNS denotes blocks
T8161 7184-7189 NNP denotes NF-κB
T8162 7190-7193 CC denotes and
T8163 7194-7198 JJ denotes AP-1
T8164 7199-7207 NN denotes activity
T8165 7207-7208 , denotes ,
T8166 7209-7219 VBG denotes suggesting
T8167 7220-7221 DT denotes a
T8168 7222-7228 JJ denotes direct
T8169 7229-7239 NN denotes regulation
T8170 7240-7242 IN denotes of
T8171 7243-7248 DT denotes these
T8172 7249-7262 NN denotes transcription
T8173 7263-7270 NNS denotes factors
T8174 7271-7273 IN denotes by
T8175 7274-7277 NNP denotes PKC
T8176 7278-7279 NNP denotes [
T8177 7279-7284 CD denotes 49,50
T8178 7284-7285 NNP denotes ]
T8179 7285-7286 . denotes .
T8180 7287-7290 NNP denotes PKC
T8181 7291-7293 VBZ denotes is
T8182 7294-7303 VBN denotes activated
T8183 7304-7306 IN denotes at
T8184 7307-7309 DT denotes an
T8185 7310-7315 JJ denotes early
T8186 7316-7321 NN denotes stage
T8187 7322-7331 VBG denotes following
T8188 7332-7338 NNP denotes T-cell
T8189 7339-7350 NN denotes stimulation
T8190 7351-7354 CC denotes and
T8191 7355-7357 VBZ denotes is
T8192 7358-7367 RB denotes therefore
T8193 7368-7370 DT denotes an
T8194 7371-7380 JJ denotes important
T8195 7381-7390 NN denotes regulator
T8196 7391-7393 IN denotes of
T8197 7394-7404 JJ denotes downstream
T8198 7405-7417 JJ denotes inflammatory
T8199 7418-7428 JJ denotes signalling
T8200 7429-7437 NNS denotes pathways
T8201 7438-7445 VBG denotes leading
T8202 7446-7448 TO denotes to
T8203 7449-7457 VB denotes cytokine
T8204 7458-7468 NN denotes expression
T8205 7469-7470 NNP denotes [
T8206 7470-7472 CD denotes 50
T8207 7472-7473 NNP denotes ]
T8208 7473-7474 . denotes .
T8209 7475-7477 PRP denotes We
T8210 7478-7482 VBP denotes have
T8211 7483-7488 VBN denotes shown
T8212 7489-7493 IN denotes that
T8213 7494-7512 NNP denotes phosphorylated-PKC
T8214 7513-7515 VBZ denotes is
T8215 7516-7518 RB denotes up
T8216 7519-7528 VBN denotes regulated
T8217 7529-7531 IN denotes in
T8218 7532-7540 NN denotes response
T8219 7541-7543 TO denotes to
T8220 7544-7547 NNP denotes PMA
T8221 7548-7551 CC denotes and
T8222 7552-7554 NNP denotes HK
T8223 7555-7557 NNP denotes E.
T8224 7558-7562 NNS denotes coli
T8225 7562-7563 , denotes ,
T8226 7564-7574 VBG denotes indicating
T8227 7575-7577 DT denotes an
T8228 7578-7589 NN denotes association
T8229 7590-7597 IN denotes between
T8230 7598-7601 NNP denotes PKC
T8231 7602-7605 CC denotes and
T8232 7606-7609 DT denotes the
T8233 7610-7623 NN denotes transcription
T8234 7624-7631 NNS denotes factors
T8235 7632-7636 NNP denotes AP-1
T8236 7637-7640 CC denotes and
T8237 7641-7646 NNP denotes NF-κB
T8238 7646-7647 . denotes .
T8239 7648-7653 JJ denotes Bcl10
T8240 7654-7660 NNS denotes levels
T8241 7661-7665 VBD denotes were
T8242 7666-7680 JJ denotes down-regulated
T8243 7681-7690 VBG denotes following
T8244 7691-7699 JJ denotes extended
T8245 7700-7709 NN denotes treatment
T8246 7710-7712 IN denotes of
T8247 7713-7719 NNP denotes Jurkat
T8248 7720-7727 NNS denotes T-cells
T8249 7728-7732 IN denotes with
T8250 7733-7736 NNP denotes PMA
T8251 7736-7737 . denotes .
T8252 7738-7740 IN denotes In
T8253 7741-7744 DT denotes the
T8254 7745-7752 NN denotes control
T8255 7753-7759 NNS denotes groups
T8256 7759-7760 , denotes ,
T8257 7761-7762 DT denotes a
T8258 7763-7767 NN denotes loss
T8259 7768-7770 IN denotes of
T8260 7771-7776 NNP denotes Bcl10
T8261 7777-7785 VBD denotes occurred
T8262 7786-7791 IN denotes after
T8263 7792-7793 CD denotes 6
T8264 7794-7795 NN denotes h
T8265 7795-7796 , denotes ,
T8266 7797-7805 VBN denotes followed
T8267 7806-7808 IN denotes by
T8268 7809-7811 DT denotes an
T8269 7812-7820 NN denotes increase
T8270 7821-7826 IN denotes after
T8271 7827-7829 CD denotes 24
T8272 7830-7831 NN denotes h
T8273 7831-7832 , denotes ,
T8274 7833-7838 WDT denotes which
T8275 7839-7841 VBZ denotes is
T8276 7842-7844 IN denotes in
T8277 7845-7855 NN denotes accordance
T8278 7856-7860 IN denotes with
T8279 7861-7864 DT denotes the
T8280 7865-7873 JJ denotes observed
T8281 7874-7879 NN denotes NF-κB
T8282 7880-7888 NN denotes activity
T8283 7889-7890 -LRB- denotes (
T8284 7890-7896 NN denotes figure
T8285 7897-7898 CD denotes 7
T8286 7898-7899 -RRB- denotes )
T8287 7899-7900 . denotes .
T8288 7901-7906 DT denotes These
T8289 7907-7914 NNS denotes results
T8290 7915-7918 VBP denotes are
T8291 7919-7928 VBN denotes supported
T8292 7929-7931 IN denotes by
T8293 7932-7934 DT denotes an
T8294 7935-7942 JJR denotes earlier
T8295 7943-7948 NN denotes study
T8296 7949-7950 NNP denotes [
T8297 7950-7952 CD denotes 47
T8298 7952-7953 NNP denotes ]
T8299 7953-7954 , denotes ,
T8300 7955-7968 VBG denotes demonstrating
T8301 7969-7973 IN denotes that
T8302 7974-7983 VBN denotes prolonged
T8303 7984-7987 NNP denotes PKC
T8304 7988-7998 NN denotes activation
T8305 7999-8001 IN denotes by
T8306 8002-8005 NNP denotes PMA
T8307 8006-8011 VBZ denotes leads
T8308 8012-8014 TO denotes to
T8309 8015-8017 DT denotes an
T8310 8018-8028 NN denotes inhibition
T8311 8029-8031 IN denotes of
T8312 8032-8037 NNP denotes Bcl10
T8313 8038-8041 CC denotes and
T8314 8042-8047 NNP denotes NF-κB
T8315 8047-8048 . denotes .
T8316 8049-8051 PRP denotes It
T8317 8052-8055 VBZ denotes has
T8318 8056-8060 VBN denotes been
T8319 8061-8066 VBN denotes shown
T8320 8067-8071 IN denotes that
T8321 8072-8077 NNP denotes NF-κB
T8322 8078-8080 VBZ denotes is
T8323 8081-8083 DT denotes an
T8324 8084-8093 JJ denotes important
T8325 8094-8107 NN denotes transcription
T8326 8108-8114 NN denotes factor
T8327 8115-8122 JJ denotes complex
T8328 8123-8131 VBN denotes involved
T8329 8132-8134 IN denotes in
T8330 8135-8141 RB denotes almost
T8331 8142-8147 DT denotes every
T8332 8148-8154 NN denotes aspect
T8333 8155-8157 IN denotes of
T8334 8158-8162 NN denotes cell
T8335 8163-8173 NN denotes regulation
T8336 8174-8183 VBG denotes including
T8337 8184-8193 NN denotes apoptosis
T8338 8193-8194 , denotes ,
T8339 8195-8210 NN denotes differentiation
T8340 8210-8211 , denotes ,
T8341 8212-8225 NN denotes proliferation
T8342 8226-8229 CC denotes and
T8343 8230-8240 NN denotes initiation
T8344 8241-8243 IN denotes of
T8345 8244-8250 JJ denotes immune
T8346 8251-8260 NNS denotes responses
T8347 8261-8262 NNP denotes [
T8348 8262-8267 CD denotes 51-53
T8349 8267-8268 NNP denotes ]
T8350 8268-8269 . denotes .
T8351 8270-8275 NN denotes NF-κB
T8352 8276-8278 VBZ denotes is
T8353 8279-8293 RB denotes constitutively
T8354 8294-8300 JJ denotes active
T8355 8301-8303 IN denotes in
T8356 8304-8308 JJ denotes many
T8357 8309-8314 JJ denotes human
T8358 8315-8327 NNS denotes malignancies
T8359 8327-8328 , denotes ,
T8360 8329-8334 WDT denotes which
T8361 8335-8340 VBZ denotes makes
T8362 8341-8343 PRP denotes it
T8363 8344-8346 DT denotes an
T8364 8347-8357 JJ denotes attractive
T8365 8358-8369 JJ denotes therapeutic
T8366 8370-8376 NN denotes target
T8367 8377-8378 NNP denotes [
T8368 8378-8380 CD denotes 54
T8369 8380-8381 NNP denotes ]
T8370 8381-8382 . denotes .
T8371 8383-8391 JJ denotes Elevated
T8372 8392-8397 NN denotes CXCL8
T8373 8398-8404 NNS denotes levels
T8374 8405-8411 IN denotes during
T8375 8412-8419 JJ denotes chronic
T8376 8420-8432 NN denotes inflammation
T8377 8433-8439 NN denotes result
T8378 8440-8442 IN denotes in
T8379 8443-8445 DT denotes an
T8380 8446-8454 JJ denotes enhanced
T8381 8455-8466 NN denotes recruitment
T8382 8467-8469 IN denotes of
T8383 8470-8476 JJ denotes immune
T8384 8477-8482 NNS denotes cells
T8385 8483-8485 TO denotes to
T8386 8486-8489 DT denotes the
T8387 8490-8494 NN denotes site
T8388 8495-8497 IN denotes of
T8389 8498-8507 NN denotes infection
T8390 8507-8508 , denotes ,
T8391 8509-8514 WDT denotes which
T8392 8515-8518 MD denotes may
T8393 8519-8523 VB denotes lead
T8394 8524-8526 TO denotes to
T8395 8527-8530 DT denotes the
T8396 8531-8542 NN denotes development
T8397 8543-8545 IN denotes of
T8398 8546-8556 JJ denotes autoimmune
T8399 8557-8565 NNS denotes diseases
T8400 8566-8575 VBG denotes following
T8401 8576-8585 NN denotes secretion
T8402 8586-8588 IN denotes of
T8403 8589-8605 JJ denotes pro-inflammatory
T8404 8606-8615 NNS denotes cytokines
T8405 8615-8616 . denotes .
T8406 8617-8619 IN denotes In
T8407 8620-8623 NNP denotes HIV
T8408 8624-8632 JJ denotes infected
T8409 8633-8640 NNS denotes persons
T8410 8640-8641 , denotes ,
T8411 8642-8647 NN denotes serum
T8412 8648-8653 NNP denotes CXCL8
T8413 8654-8660 NNS denotes levels
T8414 8661-8664 VBP denotes are
T8415 8665-8673 VBN denotes elevated
T8416 8674-8677 CC denotes and
T8417 8678-8682 DT denotes this
T8418 8683-8688 MD denotes could
T8419 8689-8696 VB denotes recruit
T8420 8697-8701 JJR denotes more
T8421 8702-8709 NNS denotes T-cells
T8422 8710-8721 RB denotes potentially
T8423 8722-8729 VBG denotes leading
T8424 8730-8732 TO denotes to
T8425 8733-8734 DT denotes a
T8426 8735-8739 RBR denotes more
T8427 8740-8745 JJ denotes rapid
T8428 8746-8757 NN denotes progression
T8429 8758-8760 IN denotes of
T8430 8761-8764 DT denotes the
T8431 8765-8772 NN denotes disease
T8432 8773-8778 IN denotes since
T8433 8779-8784 EX denotes there
T8434 8785-8789 MD denotes will
T8435 8790-8792 VB denotes be
T8436 8793-8797 RBR denotes more
T8437 8798-8805 NNS denotes T-cells
T8438 8806-8815 JJ denotes available
T8439 8816-8818 TO denotes to
T8440 8819-8825 VB denotes infect
T8441 8825-8826 . denotes .
R5398 T6906 T6909 nsubj NF-κB,are
R5399 T6907 T6906 cc and,NF-κB
R5400 T6908 T6906 conj AP-1,NF-κB
R5401 T6909 T6909 ROOT are,are
R5402 T6910 T6911 amod critical,regulators
R5403 T6911 T6909 attr regulators,are
R5404 T6912 T6911 prep of,regulators
R5405 T6913 T6914 amod inflammatory,responses
R5406 T6914 T6912 pobj responses,of
R5407 T6915 T6914 punct ",",responses
R5408 T6916 T6914 conj proliferation,responses
R5409 T6917 T6916 cc and,proliferation
R5410 T6918 T6916 conj differentiation,proliferation
R5411 T6919 T6918 prep of,differentiation
R5412 T6920 T6919 pobj T-cells,of
R5413 T6921 T6923 compound [,]
R5414 T6922 T6923 compound 28-30,]
R5415 T6923 T6934 nsubj ],is
R5416 T6924 T6923 punct ",",]
R5417 T6925 T6923 advmod however,]
R5418 T6926 T6923 punct ",",]
R5419 T6927 T6929 det the,transduction
R5420 T6928 T6929 compound signal,transduction
R5421 T6929 T6923 appos transduction,]
R5422 T6930 T6929 cc and,transduction
R5423 T6931 T6933 amod subsequent,expression
R5424 T6932 T6933 compound cytokine/chemokine,expression
R5425 T6933 T6929 conj expression,transduction
R5426 T6934 T6937 auxpass is,understood
R5427 T6935 T6937 neg not,understood
R5428 T6936 T6937 advmod fully,understood
R5429 T6937 T6909 conj understood,are
R5430 T6938 T6909 punct .,are
R5431 T6939 T6940 det The,aim
R5432 T6940 T6945 nsubj aim,was
R5433 T6941 T6940 prep of,aim
R5434 T6942 T6944 det the,study
R5435 T6943 T6944 amod present,study
R5436 T6944 T6941 pobj study,of
R5437 T6945 T6945 ROOT was,was
R5438 T6946 T6947 aux to,investigate
R5439 T6947 T6945 xcomp investigate,was
R5440 T6948 T6947 dobj IL-6,investigate
R5441 T6949 T6948 cc and,IL-6
R5442 T6950 T6951 compound CXCL8,regulation
R5443 T6951 T6947 dobj regulation,investigate
R5444 T6952 T6951 prep by,regulation
R5445 T6953 T6952 pobj NF-κB,by
R5446 T6954 T6953 cc and,NF-κB
R5447 T6955 T6953 conj AP-1,NF-κB
R5448 T6956 T6951 prep in,regulation
R5449 T6957 T6958 compound Jurkat,T-cells
R5450 T6958 T6956 pobj T-cells,in
R5451 T6959 T6945 punct .,was
R5452 T6960 T6961 poss Our,results
R5453 T6961 T6962 nsubj results,demonstrated
R5454 T6962 T6962 ROOT demonstrated,demonstrated
R5455 T6963 T6965 mark that,induced
R5456 T6964 T6965 nsubj PMA,induced
R5457 T6965 T6962 ccomp induced,demonstrated
R5458 T6966 T6967 amod AP-1,activation
R5459 T6967 T6965 dobj activation,induced
R5460 T6968 T6965 punct ",",induced
R5461 T6969 T6965 advcl indicating,induced
R5462 T6970 T6972 det a,activation
R5463 T6971 T6972 amod specific,activation
R5464 T6972 T6969 dobj activation,indicating
R5465 T6973 T6972 prep of,activation
R5466 T6974 T6976 det the,pathway
R5467 T6975 T6976 compound MAPK,pathway
R5468 T6976 T6973 pobj pathway,of
R5469 T6977 T6962 punct .,demonstrated
R5470 T6978 T6981 advmod Furthermore,demonstrated
R5471 T6979 T6981 punct ",",demonstrated
R5472 T6980 T6981 nsubj we,demonstrated
R5473 T6981 T6981 ROOT demonstrated,demonstrated
R5474 T6982 T6990 mark that,delayed
R5475 T6983 T6986 nmod PMA,activation
R5476 T6984 T6986 amod dependent,activation
R5477 T6985 T6986 compound AP-1,activation
R5478 T6986 T6990 nsubjpass activation,delayed
R5479 T6987 T6986 prep in,activation
R5480 T6988 T6987 pobj T-cells,in
R5481 T6989 T6990 auxpass was,delayed
R5482 T6990 T6981 ccomp delayed,demonstrated
R5483 T6991 T6990 punct (,delayed
R5484 T6992 T6994 meta >,h
R5485 T6993 T6994 nummod 2,h
R5486 T6994 T6990 dep h,delayed
R5487 T6995 T6994 punct ),h
R5488 T6996 T6990 cc and,delayed
R5489 T6997 T6990 conj increased,delayed
R5490 T6998 T6997 prep following,increased
R5491 T6999 T7000 amod long-term,treatment
R5492 T7000 T6998 pobj treatment,following
R5493 T7001 T6981 punct .,demonstrated
R5494 T7002 T7003 nsubj MAPK,is
R5495 T7003 T7003 ROOT is,is
R5496 T7004 T7003 attr one,is
R5497 T7005 T7004 prep of,one
R5498 T7006 T7009 det the,pathways
R5499 T7007 T7009 amod main,pathways
R5500 T7008 T7009 amod signalling,pathways
R5501 T7009 T7005 pobj pathways,of
R5502 T7010 T7009 prep in,pathways
R5503 T7011 T7010 pobj T-cells,in
R5504 T7012 T7013 nsubj that,regulate
R5505 T7013 T7011 relcl regulate,T-cells
R5506 T7014 T7013 dobj cell,regulate
R5507 T7015 T7013 punct -,regulate
R5508 T7016 T7013 cc and,regulate
R5509 T7017 T7018 amod transcriptional,activation
R5510 T7018 T7021 compound activation,]
R5511 T7019 T7021 compound [,]
R5512 T7020 T7021 compound "31,32",]
R5513 T7021 T7004 appos ],one
R5514 T7022 T7003 punct .,is
R5515 T7023 T7024 amod Several,studies
R5516 T7024 T7029 nsubj studies,indicated
R5517 T7025 T7027 compound [,]
R5518 T7026 T7027 compound "20,33,34",]
R5519 T7027 T7024 appos ],studies
R5520 T7028 T7029 aux have,indicated
R5521 T7029 T7029 ROOT indicated,indicated
R5522 T7030 T7031 det the,importance
R5523 T7031 T7029 dobj importance,indicated
R5524 T7032 T7031 prep of,importance
R5525 T7033 T7032 pobj AP-1,of
R5526 T7034 T7033 prep in,AP-1
R5527 T7035 T7036 compound T-cell,activation
R5528 T7036 T7034 pobj activation,in
R5529 T7037 T7036 cc and,activation
R5530 T7038 T7039 det the,induction
R5531 T7039 T7036 conj induction,activation
R5532 T7040 T7039 prep of,induction
R5533 T7041 T7042 amod inflammatory,responses
R5534 T7042 T7040 pobj responses,of
R5535 T7043 T7045 nmod [,]
R5536 T7044 T7045 nummod 35,]
R5537 T7045 T7039 appos ],induction
R5538 T7046 T7039 punct ",",induction
R5539 T7047 T7039 prep including,induction
R5540 T7048 T7050 amod pro-inflammatory,release
R5541 T7049 T7050 compound cytokine,release
R5542 T7050 T7047 pobj release,including
R5543 T7051 T7029 punct .,indicated
R5544 T7052 T7060 prep In,increased
R5545 T7053 T7052 pobj contrast,In
R5546 T7054 T7053 prep to,contrast
R5547 T7055 T7054 pobj AP-1,to
R5548 T7056 T7055 punct ",",AP-1
R5549 T7057 T7058 compound NF-κB,activity
R5550 T7058 T7060 nsubj activity,increased
R5551 T7059 T7060 advmod rapidly,increased
R5552 T7060 T7060 ROOT increased,increased
R5553 T7061 T7063 punct (,min
R5554 T7062 T7063 nummod 1,min
R5555 T7063 T7060 npadvmod min,increased
R5556 T7064 T7063 punct ),min
R5557 T7065 T7060 prep during,increased
R5558 T7066 T7067 compound PMA,exposure
R5559 T7067 T7065 pobj exposure,during
R5560 T7068 T7067 acl followed,exposure
R5561 T7069 T7068 agent by,followed
R5562 T7070 T7071 det a,down-regulation
R5563 T7071 T7069 pobj down-regulation,by
R5564 T7072 T7071 prep to,down-regulation
R5565 T7073 T7075 det the,levels
R5566 T7074 T7075 amod lowest,levels
R5567 T7075 T7072 pobj levels,to
R5568 T7076 T7075 prep at,levels
R5569 T7077 T7078 nummod 6,h
R5570 T7078 T7076 pobj h,at
R5571 T7079 T7060 punct .,increased
R5572 T7080 T7081 nsubj This,is
R5573 T7081 T7081 ROOT is,is
R5574 T7082 T7081 prep in,is
R5575 T7083 T7082 pobj line,in
R5576 T7084 T7083 prep with,line
R5577 T7085 T7084 pobj Park,with
R5578 T7086 T7085 cc and,Park
R5579 T7087 T7085 conj colleagues,Park
R5580 T7088 T7090 compound [,]
R5581 T7089 T7090 compound 36,]
R5582 T7090 T7087 appos ],colleagues
R5583 T7091 T7092 nsubj who,demonstrated
R5584 T7092 T7081 ccomp demonstrated,is
R5585 T7093 T7095 det a,increase
R5586 T7094 T7095 amod rapid,increase
R5587 T7095 T7092 dobj increase,demonstrated
R5588 T7096 T7095 prep in,increase
R5589 T7097 T7098 amod NF-κB,activity
R5590 T7098 T7096 pobj activity,in
R5591 T7099 T7098 prep following,activity
R5592 T7100 T7101 amod short-term,stimulation
R5593 T7101 T7099 pobj stimulation,following
R5594 T7102 T7101 prep with,stimulation
R5595 T7103 T7102 pobj PMA,with
R5596 T7104 T7092 punct ",",demonstrated
R5597 T7105 T7092 cc but,demonstrated
R5598 T7106 T7107 amod prolonged,challenge
R5599 T7107 T7108 nsubj challenge,resulted
R5600 T7108 T7092 conj resulted,demonstrated
R5601 T7109 T7108 prep in,resulted
R5602 T7110 T7112 det a,inhibition
R5603 T7111 T7112 amod persistent,inhibition
R5604 T7112 T7109 pobj inhibition,in
R5605 T7113 T7112 prep of,inhibition
R5606 T7114 T7113 pobj NF-κB,of
R5607 T7115 T7081 punct .,is
R5608 T7116 T7117 nsubj They,showed
R5609 T7117 T7117 ROOT showed,showed
R5610 T7118 T7123 mark that,was
R5611 T7119 T7120 det the,inhibition
R5612 T7120 T7123 nsubj inhibition,was
R5613 T7121 T7120 prep of,inhibition
R5614 T7122 T7121 pobj NF-κB,of
R5615 T7123 T7117 ccomp was,showed
R5616 T7124 T7123 acomp due,was
R5617 T7125 T7124 prep to,due
R5618 T7126 T7127 amod PKC-dependent,degradation
R5619 T7127 T7125 pobj degradation,to
R5620 T7128 T7127 prep of,degradation
R5621 T7129 T7131 compound IκB,β
R5622 T7130 T7131 compound kinase,β
R5623 T7131 T7128 pobj β,of
R5624 T7132 T7131 cc and,β
R5625 T7133 T7131 conj γ,β
R5626 T7134 T7123 prep in,was
R5627 T7135 T7134 pobj response,in
R5628 T7136 T7135 prep to,response
R5629 T7137 T7136 pobj PMA,to
R5630 T7138 T7117 punct .,showed
R5631 T7139 T7146 advmod Interestingly,induced
R5632 T7140 T7146 punct ",",induced
R5633 T7141 T7145 det the,exposure
R5634 T7142 T7145 compound HK,exposure
R5635 T7143 T7145 compound E.,exposure
R5636 T7144 T7145 compound coli,exposure
R5637 T7145 T7146 nsubj exposure,induced
R5638 T7146 T7146 ROOT induced,induced
R5639 T7147 T7148 amod NF-κB,activation
R5640 T7148 T7146 dobj activation,induced
R5641 T7149 T7146 prep without,induced
R5642 T7150 T7149 pcomp affecting,without
R5643 T7151 T7152 amod AP-1,activity
R5644 T7152 T7150 dobj activity,affecting
R5645 T7153 T7146 punct .,induced
R5646 T7154 T7160 nsubj Wang,reported
R5647 T7155 T7154 cc and,Wang
R5648 T7156 T7159 nmod colleagues,]
R5649 T7157 T7156 appos [,colleagues
R5650 T7158 T7159 nummod 37,]
R5651 T7159 T7154 conj ],Wang
R5652 T7160 T7160 ROOT reported,reported
R5653 T7161 T7164 det an,response
R5654 T7162 T7164 amod elevated,response
R5655 T7163 T7164 amod inflammatory,response
R5656 T7164 T7160 dobj response,reported
R5657 T7165 T7164 prep by,response
R5683 T7191 T7190 acomp due,be
R5684 T7192 T7191 pcomp to,due
R5685 T7193 T7198 det the,calmodulin
R5686 T7194 T7198 nmod Ca2,calmodulin
R5687 T7195 T7198 compound +,calmodulin
R5688 T7196 T7197 amod binding,protein
R5689 T7197 T7198 compound protein,calmodulin
R5690 T7198 T7192 pobj calmodulin,to
R5691 T7199 T7198 punct (,calmodulin
R5692 T7200 T7198 appos CaM,calmodulin
R5693 T7201 T7200 punct ),CaM
R5694 T7202 T7198 punct ",",calmodulin
R5695 T7203 T7206 nsubjpass which,shown
R5696 T7204 T7206 aux has,shown
R5697 T7205 T7206 auxpass been,shown
R5698 T7206 T7198 relcl shown,calmodulin
R5699 T7207 T7209 aux to,regulate
R5700 T7208 T7209 advmod negatively,regulate
R5701 T7209 T7206 xcomp regulate,shown
R5702 T7210 T7209 dobj c-Rel,regulate
R5703 T7211 T7212 advmod when,activated
R5704 T7212 T7206 advcl activated,shown
R5705 T7213 T7215 nmod [,]
R5706 T7214 T7215 nummod 38,]
R5707 T7215 T7212 dobj ],activated
R5708 T7216 T7190 punct .,be
R5709 T7217 T7218 det The,regulation
R5710 T7218 T7223 nsubj regulation,observed
R5711 T7219 T7218 prep of,regulation
R5712 T7220 T7219 pobj NF-κB,of
R5713 T7221 T7220 cc and,NF-κB
R5714 T7222 T7220 conj AP-1,NF-κB
R5715 T7223 T7223 ROOT observed,observed
R5716 T7224 T7223 prep in,observed
R5717 T7225 T7227 det the,study
R5718 T7226 T7227 amod present,study
R5719 T7227 T7224 pobj study,in
R5720 T7228 T7223 ccomp was,observed
R5721 T7229 T7228 prep in,was
R5722 T7230 T7229 pobj agreement,in
R5723 T7231 T7230 prep with,agreement
R5724 T7232 T7233 amod earlier,studies
R5725 T7233 T7231 pobj studies,with
R5726 T7234 T7223 punct .,observed
R5727 T7235 T7236 nsubj T-cells,produce
R5728 T7236 T7236 ROOT produce,produce
R5729 T7237 T7239 det a,range
R5730 T7238 T7239 amod broad,range
R5731 T7239 T7236 dobj range,produce
R5732 T7240 T7239 prep of,range
R5733 T7241 T7244 amod pro-,cytokines
R5734 T7242 T7241 cc and,pro-
R5735 T7243 T7241 conj anti-inflammatory,pro-
R5736 T7244 T7240 pobj cytokines,of
R5737 T7245 T7244 punct ",",cytokines
R5738 T7246 T7244 prep including,cytokines
R5739 T7247 T7246 pobj IL-2,including
R5740 T7248 T7247 punct ",",IL-2
R5741 T7249 T7247 conj IL-6,IL-2
R5742 T7250 T7249 punct ",",IL-6
R5743 T7251 T7249 conj CXCL8,IL-6
R5744 T7252 T7251 punct ",",CXCL8
R5745 T7253 T7251 conj TNF,CXCL8
R5746 T7254 T7253 cc and,TNF
R5747 T7255 T7253 conj IL-10,TNF
R5748 T7256 T7239 punct ",",range
R5749 T7257 T7236 prep in,produce
R5750 T7258 T7257 pobj response,in
R5751 T7259 T7258 prep to,response
R5752 T7260 T7259 pobj infections,to
R5753 T7261 T7260 cc or,infections
R5754 T7262 T7264 amod other,factors
R5755 T7263 T7264 amod stress,factors
R5756 T7264 T7260 conj factors,infections
R5757 T7265 T7267 nmod [,]
R5758 T7266 T7267 nummod 39,]
R5759 T7267 T7264 nmod ],factors
R5760 T7268 T7236 punct .,produce
R5761 T7269 T7270 det The,assessment
R5762 T7270 T7280 nsubj assessment,revealed
R5763 T7271 T7270 prep of,assessment
R5764 T7272 T7273 nmod Jurkat,T-cell
R5765 T7273 T7275 nmod T-cell,responses
R5766 T7274 T7275 amod inflammatory,responses
R5767 T7275 T7271 pobj responses,of
R5768 T7276 T7277 punct (,Table
R5769 T7277 T7275 appos Table,responses
R5770 T7278 T7277 nummod 1,Table
R5771 T7279 T7270 punct ),assessment
R5772 T7280 T7280 ROOT revealed,revealed
R5773 T7281 T7284 det an,expression
R5774 T7282 T7284 amod enhanced,expression
R5775 T7283 T7284 compound IL-2,expression
R5776 T7284 T7280 dobj expression,revealed
R5777 T7285 T7284 prep upon,expression
R5778 T7286 T7285 pobj exposure,upon
R5779 T7287 T7286 prep to,exposure
R5780 T7288 T7287 pobj PMA,to
R5781 T7289 T7288 cc or,PMA
R5782 T7290 T7292 compound HK,coli
R5783 T7291 T7292 compound E.,coli
R5784 T7292 T7288 conj coli,PMA
R5785 T7293 T7284 amod due,expression
R5786 T7294 T7293 prep to,due
R5787 T7295 T7294 pobj PKC,to
R5788 T7296 T7299 compound activation,]
R5789 T7297 T7299 nmod [,]
R5790 T7298 T7299 nummod 40,]
R5791 T7299 T7295 dobj ],PKC
R5792 T7300 T7280 punct .,revealed
R5793 T7301 T7314 prep In,identified
R5794 T7302 T7301 pobj addition,In
R5795 T7303 T7302 prep to,addition
R5796 T7304 T7306 det the,factor
R5797 T7305 T7306 compound transcription,factor
R5798 T7306 T7303 pobj factor,to
R5799 T7307 T7306 appos NF-κB,factor
R5800 T7308 T7314 punct ",",identified
R5801 T7309 T7311 nmod AP-1,sites
R5802 T7310 T7311 amod binding,sites
R5803 T7311 T7314 nsubjpass sites,identified
R5804 T7312 T7314 aux have,identified
R5805 T7313 T7314 auxpass been,identified
R5806 T7314 T7314 ROOT identified,identified
R5807 T7315 T7314 prep in,identified
R5808 T7316 T7319 det the,region
R5809 T7317 T7319 compound IL-6,region
R5810 T7318 T7319 compound promoter,region
R5811 T7319 T7315 pobj region,in
R5812 T7320 T7314 punct ",",identified
R5813 T7321 T7314 advcl indicating,identified
R5814 T7322 T7323 amod multiple,regulation
R5815 T7323 T7321 dobj regulation,indicating
R5816 T7324 T7326 nmod [,]
R5817 T7325 T7326 nummod 22,]
R5818 T7326 T7323 appos ],regulation
R5819 T7327 T7314 punct .,identified
R5820 T7328 T7334 nsubj AP-1,demonstrated
R5821 T7329 T7328 cc and,AP-1
R5822 T7330 T7328 conj NF-κB,AP-1
R5823 T7331 T7334 aux have,demonstrated
R5824 T7332 T7334 advmod also,demonstrated
R5825 T7333 T7334 auxpass been,demonstrated
R5826 T7334 T7334 ROOT demonstrated,demonstrated
R5827 T7335 T7336 aux to,regulate
R5828 T7336 T7334 xcomp regulate,demonstrated
R5829 T7337 T7338 compound CXCL8,expression
R5830 T7338 T7336 dobj expression,regulate
R5831 T7339 T7336 prep during,regulate
R5832 T7340 T7339 pobj induction,during
R5833 T7341 T7340 prep of,induction
R5834 T7342 T7343 amod inflammatory,responses
R5835 T7343 T7341 pobj responses,of
R5836 T7344 T7343 prep in,responses
R5837 T7345 T7344 pobj T-cells,in
R5838 T7346 T7348 nmod [,]
R5839 T7347 T7348 nummod 12,]
R5840 T7348 T7345 appos ],T-cells
R5841 T7349 T7334 punct .,demonstrated
R5842 T7350 T7357 advmod Furthermore,associated
R5843 T7351 T7357 punct ",",associated
R5844 T7352 T7357 nsubjpass IL-6,associated
R5845 T7353 T7352 cc and,IL-6
R5846 T7354 T7352 conj CXCL8,IL-6
R5847 T7355 T7357 nsubjpass gene-expression,associated
R5848 T7356 T7357 auxpass is,associated
R5849 T7357 T7357 ROOT associated,associated
R5850 T7358 T7357 prep with,associated
R5851 T7359 T7362 det an,response
R5852 T7360 T7362 amod early,response
R5853 T7361 T7362 amod immune,response
R5854 T7362 T7358 pobj response,with
R5855 T7363 T7362 prep in,response
R5856 T7364 T7365 compound Jurkat,T-cells
R5857 T7365 T7363 pobj T-cells,in
R5858 T7366 T7368 nmod [,]
R5859 T7367 T7368 nummod 41,]
R5860 T7368 T7365 appos ],T-cells
R5861 T7369 T7357 punct .,associated
R5862 T7370 T7381 prep In,resulted
R5863 T7371 T7373 det the,study
R5864 T7372 T7373 amod present,study
R5865 T7373 T7370 pobj study,In
R5866 T7374 T7381 punct ",",resulted
R5867 T7375 T7376 det both,PMA
R5868 T7376 T7381 nsubj PMA,resulted
R5869 T7377 T7376 cc and,PMA
R5870 T7378 T7380 compound HK,coli
R5871 T7379 T7380 compound E.,coli
R5872 T7380 T7376 conj coli,PMA
R5873 T7381 T7381 ROOT resulted,resulted
R5874 T7382 T7381 prep in,resulted
R5875 T7383 T7384 amod comparable,increases
R5876 T7384 T7382 pobj increases,in
R5877 T7385 T7384 prep in,increases
R5878 T7386 T7385 pobj IL-6,in
R5879 T7387 T7389 mark while,was
R5880 T7388 T7389 nsubj PMA,was
R5881 T7389 T7381 advcl was,resulted
R5882 T7390 T7391 advmod more,potent
R5883 T7391 T7389 acomp potent,was
R5884 T7392 T7391 prep at,potent
R5885 T7393 T7392 pcomp activating,at
R5886 T7394 T7395 compound CXCL8,release
R5887 T7395 T7393 dobj release,activating
R5888 T7396 T7381 punct .,resulted
R5889 T7397 T7404 nsubj PMA,induced
R5890 T7398 T7397 cc and,PMA
R5891 T7399 T7401 compound HK,coli
R5892 T7400 T7401 compound E.,coli
R5893 T7401 T7402 compound coli,treatment
R5894 T7402 T7397 conj treatment,PMA
R5895 T7403 T7404 advmod also,induced
R5896 T7404 T7404 ROOT induced,induced
R5897 T7405 T7406 compound TNF,expression
R5898 T7406 T7404 dobj expression,induced
R5899 T7407 T7404 punct .,induced
R5900 T7408 T7409 nsubj TNF,is
R5901 T7409 T7409 ROOT is,is
R5902 T7410 T7409 attr one,is
R5903 T7411 T7410 prep of,one
R5904 T7412 T7414 det the,cytokines
R5905 T7413 T7414 amod first,cytokines
R5906 T7414 T7411 pobj cytokines,of
R5907 T7415 T7414 acl induced,cytokines
R5908 T7416 T7415 agent by,induced
R5909 T7417 T7416 pobj T-cells,by
R5910 T7418 T7420 nmod [,]
R5911 T7419 T7420 nummod 42,]
R5912 T7420 T7417 appos ],T-cells
R5913 T7421 T7420 cc and,]
R5914 T7422 T7423 poss its,expression
R5915 T7423 T7425 nsubjpass expression,regulated
R5916 T7424 T7425 auxpass is,regulated
R5917 T7425 T7410 relcl regulated,one
R5918 T7426 T7425 agent by,regulated
R5919 T7427 T7426 pobj calcineurin,by
R5920 T7428 T7427 punct ",",calcineurin
R5921 T7429 T7436 nmod NFAT,]
R5922 T7430 T7429 cc and,NFAT
R5923 T7431 T7434 compound ATF-2,[
R5924 T7432 T7434 compound /,[
R5925 T7433 T7434 compound Jun,[
R5926 T7434 T7429 conj [,NFAT
R5927 T7435 T7436 nummod 20,]
R5928 T7436 T7427 appos ],calcineurin
R5929 T7437 T7409 punct .,is
R5930 T7438 T7443 advmod However,showed
R5931 T7439 T7443 punct ",",showed
R5932 T7440 T7442 amod PMA-stimulated,T-cells
R5933 T7441 T7442 compound Jurkat,T-cells
R5934 T7442 T7443 nsubj T-cells,showed
R5935 T7443 T7443 ROOT showed,showed
R5936 T7444 T7445 det no,difference
R5937 T7445 T7443 dobj difference,showed
R5938 T7446 T7445 prep in,difference
R5939 T7447 T7448 compound IL-10,expression
R5940 T7448 T7446 pobj expression,in
R5941 T7449 T7443 advcl indicating,showed
R5942 T7450 T7453 det an,response
R5943 T7451 T7453 amod induced,response
R5944 T7452 T7453 amod inflammatory,response
R5945 T7453 T7449 dobj response,indicating
R5946 T7454 T7443 punct .,showed
R5947 T7455 T7458 compound HK,treatment
R5948 T7456 T7458 compound E.,treatment
R5949 T7457 T7458 compound coli,treatment
R5950 T7458 T7459 nsubj treatment,resulted
R5951 T7459 T7459 ROOT resulted,resulted
R5952 T7460 T7459 prep in,resulted
R5953 T7461 T7463 det a,reduction
R5954 T7462 T7463 amod significant,reduction
R5955 T7463 T7460 pobj reduction,in
R5956 T7464 T7463 prep of,reduction
R5957 T7465 T7466 compound IL-10,expression
R5958 T7466 T7464 pobj expression,of
R5959 T7467 T7459 punct .,resulted
R5960 T7468 T7471 det The,IL-10
R5961 T7469 T7471 amod anti-inflammatory,IL-10
R5962 T7470 T7471 compound cytokine,IL-10
R5963 T7471 T7473 nsubjpass IL-10,known
R5964 T7472 T7473 auxpass is,known
R5965 T7473 T7473 ROOT known,known
R5966 T7474 T7475 aux to,inhibit
R5967 T7475 T7473 xcomp inhibit,known
R5968 T7476 T7477 compound T-cell,activation
R5969 T7477 T7475 dobj activation,inhibit
R5970 T7478 T7477 punct ",",activation
R5971 T7479 T7477 conj proliferation,activation
R5972 T7480 T7479 cc and,proliferation
R5973 T7481 T7482 det the,expression
R5974 T7482 T7479 conj expression,proliferation
R5975 T7483 T7482 prep of,expression
R5976 T7484 T7485 amod pro-inflammatory,cytokines
R5977 T7485 T7483 pobj cytokines,of
R5978 T7486 T7485 punct ",",cytokines
R5979 T7487 T7488 amod such,as
R5980 T7488 T7485 prep as,cytokines
R5981 T7489 T7488 pobj IL-2,as
R5982 T7490 T7489 punct ",",IL-2
R5983 T7491 T7489 conj IL-5,IL-2
R5984 T7492 T7491 cc and,IL-5
R5985 T7493 T7494 compound INF-γ,[
R5986 T7494 T7491 conj [,IL-5
R5987 T7495 T7496 compound "39,43",]
R5988 T7496 T7494 dobj ],[
R5989 T7497 T7482 cc and,expression
R5990 T7498 T7475 conj regulate,inhibit
R5991 T7499 T7500 amod inflammatory,responses
R5992 T7500 T7498 dobj responses,regulate
R5993 T7501 T7498 prep by,regulate
R5994 T7502 T7501 pcomp inducing,by
R5995 T7503 T7504 compound T-cell,anergy
R5996 T7504 T7505 compound anergy,[
R5997 T7505 T7502 dobj [,inducing
R5998 T7506 T7507 nummod 44,]
R5999 T7507 T7505 appos ],[
R6000 T7508 T7473 punct .,known
R6001 T7509 T7512 det The,analysis
R6002 T7510 T7512 compound time,analysis
R6003 T7511 T7512 compound course,analysis
R6004 T7512 T7516 nsubj analysis,showed
R6005 T7513 T7512 prep of,analysis
R6006 T7514 T7515 compound cytokine,expression
R6007 T7515 T7513 pobj expression,of
R6008 T7516 T7516 ROOT showed,showed
R6009 T7517 T7518 det a,correlation
R6010 T7518 T7516 dobj correlation,showed
R6011 T7519 T7518 prep between,correlation
R6012 T7520 T7519 pobj AP-1,between
R6013 T7521 T7520 cc and,AP-1
R6014 T7522 T7524 det the,CXCL8
R6015 T7523 T7524 compound chemokine,CXCL8
R6016 T7524 T7520 conj CXCL8,AP-1
R6017 T7525 T7530 advmod where,elevated
R6018 T7526 T7527 compound CXCL8,expression
R6019 T7527 T7530 nsubjpass expression,elevated
R6020 T7528 T7530 auxpass was,elevated
R6021 T7529 T7530 advmod significantly,elevated
R6022 T7530 T7524 relcl elevated,CXCL8
R6023 T7531 T7530 advmod already,elevated
R6024 T7532 T7530 prep at,elevated
R6025 T7533 T7534 nummod 2-6,h
R6026 T7534 T7532 pobj h,at
R6027 T7535 T7530 prep after,elevated
R6028 T7536 T7537 compound PMA,exposure
R6029 T7537 T7535 pobj exposure,after
R6030 T7538 T7516 punct .,showed
R6031 T7539 T7541 det The,expression
R6032 T7540 T7541 compound CXCL8,expression
R6033 T7541 T7544 nsubj expression,correlate
R6034 T7542 T7544 aux did,correlate
R6035 T7543 T7544 neg not,correlate
R6036 T7544 T7544 ROOT correlate,correlate
R6037 T7545 T7544 prep with,correlate
R6038 T7546 T7549 det the,activation
R6039 T7547 T7549 amod early,activation
R6040 T7548 T7549 compound NF-κB,activation
R6041 T7549 T7545 pobj activation,with
R6042 T7550 T7552 punct (,min
R6043 T7551 T7552 nummod 1,min
R6044 T7552 T7549 appos min,activation
R6045 T7553 T7552 punct ),min
R6046 T7554 T7545 cc or,with
R6047 T7555 T7545 conj with,with
R6048 T7556 T7557 det the,down-regulation
R6049 T7557 T7555 pobj down-regulation,with
R6050 T7558 T7557 prep of,down-regulation
R6051 T7559 T7558 pobj NF-κB,of
R6052 T7560 T7557 prep at,down-regulation
R6053 T7561 T7564 nummod 2,exposure
R6054 T7562 T7563 compound h,post
R6055 T7563 T7564 compound post,exposure
R6056 T7564 T7560 pobj exposure,at
R6057 T7565 T7544 punct .,correlate
R6058 T7566 T7567 det Both,IL-6
R6059 T7567 T7573 nsubjpass IL-6,regulated
R6060 T7568 T7567 cc and,IL-6
R6061 T7569 T7567 conj TNF,IL-6
R6062 T7570 T7567 conj expression,IL-6
R6063 T7571 T7573 auxpass were,regulated
R6064 T7572 T7573 advmod up,regulated
R6065 T7573 T7573 ROOT regulated,regulated
R6066 T7574 T7573 prep between,regulated
R6067 T7575 T7576 nummod 6-24,h
R6068 T7576 T7574 pobj h,between
R6069 T7577 T7573 punct .,regulated
R6070 T7578 T7583 prep During,increased
R6071 T7579 T7580 det this,period
R6072 T7580 T7578 pobj period,During
R6073 T7581 T7583 punct ",",increased
R6074 T7582 T7583 nsubj NF-κB,increased
R6075 T7583 T7583 ROOT increased,increased
R6076 T7584 T7583 prep from,increased
R6077 T7585 T7587 poss its,level
R6078 T7586 T7587 amod minimum,level
R6079 T7587 T7584 pobj level,from
R6080 T7588 T7587 prep at,level
R6081 T7589 T7590 nummod 6,h.
R6082 T7590 T7591 compound h.,PKC
R6083 T7591 T7588 pobj PKC,at
R6084 T7592 T7594 aux has,shown
R6085 T7593 T7594 auxpass been,shown
R6086 T7594 T7583 conj shown,increased
R6087 T7595 T7597 aux to,associated
R6088 T7596 T7597 auxpass be,associated
R6089 T7597 T7594 xcomp associated,shown
R6090 T7598 T7597 prep with,associated
R6091 T7599 T7600 det the,activation
R6092 T7600 T7598 pobj activation,with
R6093 T7601 T7600 prep of,activation
R6094 T7602 T7601 pobj AP-1,of
R6095 T7603 T7594 punct ",",shown
R6096 T7604 T7594 cc but,shown
R6097 T7605 T7606 neg not,with
R6098 T7606 T7594 conj with,shown
R6099 T7607 T7608 amod NF-κB,activation
R6100 T7608 T7606 pobj activation,with
R6101 T7609 T7608 prep of,activation
R6102 T7610 T7612 det the,promoter
R6103 T7611 T7612 compound IL-2,promoter
R6104 T7612 T7615 nmod promoter,]
R6105 T7613 T7612 appos [,promoter
R6106 T7614 T7615 nummod 45,]
R6107 T7615 T7609 pobj ],of
R6108 T7616 T7583 punct .,increased
R6109 T7617 T7624 nsubj Mutation,affect
R6110 T7618 T7617 prep of,Mutation
R6111 T7619 T7621 det the,site
R6112 T7620 T7621 compound NF-κB,site
R6113 T7621 T7618 pobj site,of
R6114 T7622 T7624 aux did,affect
R6115 T7623 T7624 neg not,affect
R6116 T7624 T7624 ROOT affect,affect
R6117 T7625 T7626 compound IL-2,expression
R6118 T7626 T7624 dobj expression,affect
R6119 T7627 T7624 punct ",",affect
R6120 T7628 T7638 mark whereas,revoked
R6121 T7629 T7638 nsubj mutation,revoked
R6122 T7630 T7629 prep of,mutation
R6123 T7631 T7633 det the,site
R6124 T7632 T7633 compound AP-1,site
R6125 T7633 T7630 pobj site,of
R6126 T7634 T7633 cc or,site
R6127 T7635 T7636 compound PKC,depletion
R6128 T7636 T7633 conj depletion,site
R6129 T7637 T7638 advmod almost,revoked
R6130 T7638 T7624 advcl revoked,affect
R6131 T7639 T7640 compound IL-2,release
R6132 T7640 T7638 dobj release,revoked
R6133 T7641 T7624 punct .,affect
R6134 T7642 T7643 det These,observations
R6135 T7643 T7644 nsubj observations,indicate
R6136 T7644 T7644 ROOT indicate,indicate
R6137 T7645 T7654 mark that,play
R6138 T7646 T7648 det the,pathway
R6139 T7647 T7648 compound MAPK,pathway
R6140 T7648 T7654 nsubj pathway,play
R6141 T7649 T7648 cc and,pathway
R6142 T7650 T7652 det the,factor
R6143 T7651 T7652 compound transcription,factor
R6144 T7652 T7654 nsubj factor,play
R6145 T7653 T7654 nsubj AP-1,play
R6146 T7654 T7644 ccomp play,indicate
R6147 T7655 T7657 det an,role
R6148 T7656 T7657 amod important,role
R6152 T7660 T7658 pobj induction,in
R6153 T7661 T7660 prep of,induction
R6154 T7662 T7663 amod inflammatory,responses
R6155 T7663 T7661 pobj responses,of
R6156 T7664 T7663 prep in,responses
R6157 T7665 T7666 compound Jurkat,T-cells
R6158 T7666 T7664 pobj T-cells,in
R6159 T7667 T7669 compound [,]
R6160 T7668 T7669 compound "12,20,22",]
R6161 T7669 T7666 appos ],T-cells
R6162 T7670 T7644 punct .,indicate
R6163 T7671 T7673 det The,results
R6164 T7672 T7673 amod obtained,results
R6165 T7673 T7674 nsubj results,signify
R6166 T7674 T7674 ROOT signify,signify
R6167 T7675 T7679 mark that,regulated
R6168 T7676 T7679 nsubjpass CXCL8,regulated
R6169 T7677 T7679 auxpass was,regulated
R6170 T7678 T7679 advmod primarily,regulated
R6171 T7679 T7674 ccomp regulated,signify
R6172 T7680 T7679 prep through,regulated
R6173 T7681 T7683 det the,pathway
R6174 T7682 T7683 compound MAPK,pathway
R6175 T7683 T7680 pobj pathway,through
R6176 T7684 T7674 punct .,signify
R6177 T7685 T7688 det The,inhibitor
R6178 T7686 T7688 amod NF-κB,inhibitor
R6179 T7687 T7688 compound activation,inhibitor
R6180 T7688 T7692 nsubj inhibitor,showed
R6181 T7689 T7690 punct (,NAI
R6182 T7690 T7688 appos NAI,inhibitor
R6183 T7691 T7688 punct ),inhibitor
R6184 T7692 T7692 ROOT showed,showed
R6185 T7693 T7692 dobj specificity,showed
R6186 T7694 T7693 prep against,specificity
R6187 T7695 T7694 pobj NF-κB,against
R6188 T7696 T7692 cc and,showed
R6189 T7697 T7692 conj resulted,showed
R6190 T7698 T7697 prep in,resulted
R6191 T7699 T7702 det a,inhibition
R6192 T7700 T7702 amod complete,inhibition
R6193 T7701 T7702 compound IL-6,inhibition
R6194 T7702 T7698 pobj inhibition,in
R6195 T7703 T7697 advcl following,resulted
R6196 T7704 T7703 pobj induction,following
R6197 T7705 T7704 prep with,induction
R6198 T7706 T7705 pobj PMA,with
R6199 T7707 T7706 cc and,PMA
R6200 T7708 T7710 amod significant,reduction
R6201 T7709 T7710 compound IL-6,reduction
R6202 T7710 T7704 conj reduction,induction
R6203 T7711 T7704 prep after,induction
R6204 T7712 T7715 nmod HK,treatment
R6205 T7713 T7715 compound E.,treatment
R6206 T7714 T7715 compound coli,treatment
R6207 T7715 T7711 pobj treatment,after
R6208 T7716 T7692 punct .,showed
R6209 T7717 T7718 nsubj CXCL8,was
R6210 T7718 T7721 auxpass was,regulated
R6211 T7719 T7720 advmod highly,up
R6212 T7720 T7721 advmod up,regulated
R6213 T7721 T7721 ROOT regulated,regulated
R6214 T7722 T7721 agent by,regulated
R6215 T7723 T7722 pobj PMA,by
R6216 T7724 T7723 cc and,PMA
R6217 T7725 T7726 det the,addition
R6218 T7726 T7723 conj addition,PMA
R6219 T7727 T7726 prep of,addition
R6220 T7728 T7727 pobj NAI,of
R6221 T7729 T7721 conj resulted,regulated
R6222 T7730 T7729 prep in,resulted
R6223 T7731 T7733 det a,reduction
R6224 T7732 T7733 amod minor,reduction
R6225 T7733 T7730 pobj reduction,in
R6226 T7734 T7733 prep in,reduction
R6227 T7735 T7736 nummod CXCL8,expression
R6228 T7736 T7734 pobj expression,in
R6229 T7737 T7721 punct .,regulated
R6230 T7738 T7744 advmod Furthermore,affected
R6231 T7739 T7744 punct ",",affected
R6232 T7740 T7741 compound CXCL8,expression
R6233 T7741 T7744 nsubjpass expression,affected
R6234 T7742 T7744 auxpass was,affected
R6235 T7743 T7744 neg not,affected
R6236 T7744 T7744 ROOT affected,affected
R6237 T7745 T7744 agent by,affected
R6238 T7746 T7745 pobj NAI,by
R6239 T7747 T7744 prep following,affected
R6240 T7748 T7751 compound HK,treatment
R6241 T7749 T7751 compound E.,treatment
R6242 T7750 T7751 compound coli,treatment
R6243 T7751 T7747 pobj treatment,following
R6244 T7752 T7744 punct ",",affected
R6245 T7753 T7744 advcl indicating,affected
R6246 T7754 T7755 det a,lack
R6247 T7755 T7753 dobj lack,indicating
R6248 T7756 T7755 prep of,lack
R6249 T7757 T7756 pobj correlation,of
R6250 T7758 T7757 prep between,correlation
R6251 T7759 T7758 pobj CXCL8,between
R6252 T7760 T7759 cc and,CXCL8
R6253 T7761 T7759 conj NF-κB,CXCL8
R6254 T7762 T7744 punct .,affected
R6255 T7763 T7764 amod Further,analysis
R6256 T7764 T7768 nsubj analysis,revealed
R6257 T7765 T7764 prep of,analysis
R6258 T7766 T7767 nummod CXCL8,expression
R6259 T7767 T7765 pobj expression,of
R6260 T7768 T7768 ROOT revealed,revealed
R6261 T7769 T7770 det a,down-regulation
R6262 T7770 T7777 nmod down-regulation,inhibitors
R6263 T7771 T7770 prep by,down-regulation
R6264 T7772 T7771 pobj PKC,by
R6265 T7773 T7770 punct -,down-regulation
R6266 T7774 T7770 cc and,down-regulation
R6267 T7775 T7770 conj JNK,down-regulation
R6268 T7776 T7777 punct -,inhibitors
R6269 T7777 T7768 dobj inhibitors,revealed
R6270 T7778 T7777 punct ",",inhibitors
R6271 T7779 T7777 acl suggesting,inhibitors
R6272 T7780 T7781 det an,involvement
R6273 T7781 T7779 dobj involvement,suggesting
R6274 T7782 T7781 prep of,involvement
R6275 T7783 T7782 pobj AP-1,of
R6276 T7784 T7777 prep via,inhibitors
R6277 T7785 T7784 pobj PKC,via
R6278 T7786 T7785 cc and,PKC
R6279 T7787 T7785 conj JNK,PKC
R6280 T7788 T7785 punct ",",PKC
R6281 T7789 T7768 advmod respectively,revealed
R6282 T7790 T7768 punct .,revealed
R6283 T7791 T7796 nsubj Analysis,confirmed
R6284 T7792 T7791 prep of,Analysis
R6285 T7793 T7794 compound gene,expression
R6286 T7794 T7792 pobj expression,of
R6287 T7795 T7796 advmod further,confirmed
R6288 T7796 T7796 ROOT confirmed,confirmed
R6289 T7797 T7802 mark that,upregulated
R6290 T7798 T7802 nsubjpass il-6,upregulated
R6291 T7799 T7798 cc and,il-6
R6292 T7800 T7798 conj cxcl8,il-6
R6293 T7801 T7802 auxpass were,upregulated
R6294 T7802 T7796 ccomp upregulated,confirmed
R6295 T7803 T7802 agent by,upregulated
R6296 T7804 T7803 pobj PMA,by
R6297 T7805 T7796 punct .,confirmed
R6298 T7806 T7809 nsubj Expression,dropped
R6299 T7807 T7806 prep of,Expression
R6300 T7808 T7807 pobj il-6,of
R6301 T7809 T7809 ROOT dropped,dropped
R6302 T7810 T7809 prep below,dropped
R6303 T7811 T7812 amod basal,levels
R6304 T7812 T7810 pobj levels,below
R6305 T7813 T7809 prep following,dropped
R6306 T7814 T7813 pobj inhibition,following
R6307 T7815 T7814 prep of,inhibition
R6308 T7816 T7815 pobj NF-κB,of
R6309 T7817 T7816 cc and,NF-κB
R6310 T7818 T7816 conj JNK,NF-κB
R6311 T7819 T7821 mark whereas,remained
R6312 T7820 T7821 nsubj cxcl8,remained
R6313 T7821 T7809 advcl remained,dropped
R6314 T7822 T7821 acomp elevated,remained
R6315 T7823 T7822 prep above,elevated
R6316 T7824 T7825 amod basal,levels
R6317 T7825 T7823 pobj levels,above
R6318 T7826 T7827 punct (,16.5-fold
R6319 T7827 T7830 nmod 16.5-fold,respectively
R6320 T7828 T7827 cc and,16.5-fold
R6321 T7829 T7827 conj 7.1-fold,16.5-fold
R6322 T7830 T7821 advmod respectively,remained
R6323 T7831 T7809 punct ),dropped
R6324 T7832 T7809 prep following,dropped
R6325 T7833 T7835 det the,treatment
R6326 T7834 T7835 amod same,treatment
R6327 T7835 T7832 dobj treatment,following
R6328 T7836 T7809 punct .,dropped
R6329 T7837 T7844 advmod Furthermore,result
R6330 T7838 T7844 punct ",",result
R6331 T7839 T7844 nsubj inhibition,result
R6332 T7840 T7839 prep of,inhibition
R6333 T7841 T7840 pobj PKC,of
R6334 T7842 T7844 aux did,result
R6335 T7843 T7844 neg not,result
R6336 T7844 T7844 ROOT result,result
R6337 T7845 T7844 prep in,result
R6338 T7846 T7848 det a,decrease
R6339 T7847 T7848 amod significant,decrease
R6340 T7848 T7845 pobj decrease,in
R6341 T7849 T7848 prep of,decrease
R6342 T7850 T7865 dobj il-6,.
R6343 T7851 T7850 cc or,il-6
R6344 T7852 T7850 conj cxcl8,il-6
R6345 T7853 T7850 punct ",",il-6
R6346 T7854 T7855 nsubj which,is
R6347 T7855 T7850 relcl is,il-6
R6348 T7856 T7855 prep in,is
R6349 T7857 T7856 pobj accordance,in
R6350 T7858 T7857 prep with,accordance
R6351 T7859 T7860 compound protein,data
R6352 T7860 T7858 pobj data,with
R6353 T7861 T7862 punct (,figure
R6354 T7862 T7860 parataxis figure,data
R6355 T7863 T7862 nummod 6,figure
R6356 T7864 T7862 punct ),figure
R6357 T7865 T7844 punct .,result
R6358 T7866 T7867 det These,results
R6359 T7867 T7868 nsubj results,suggest
R6360 T7868 T7868 ROOT suggest,suggest
R6361 T7869 T7872 mark that,involved
R6362 T7870 T7872 nsubjpass NF-κB,involved
R6363 T7871 T7872 auxpass is,involved
R6364 T7872 T7868 ccomp involved,suggest
R6365 T7873 T7872 prep in,involved
R6366 T7874 T7875 compound IL-6,regulation
R6367 T7875 T7873 pobj regulation,in
R6368 T7876 T7875 cc and,regulation
R6369 T7877 T7875 conj release,regulation
R6370 T7878 T7882 mark while,required
R6371 T7879 T7882 nsubjpass it,required
R6372 T7880 T7882 auxpass is,required
R6373 T7881 T7882 neg not,required
R6374 T7882 T7872 advcl required,involved
R6375 T7883 T7882 prep for,required
R6376 T7884 T7885 det the,expression
R6377 T7885 T7883 pobj expression,for
R6378 T7886 T7885 prep of,expression
R6379 T7887 T7886 pobj CXCL8,of
R6380 T7888 T7882 prep in,required
R6381 T7889 T7890 compound Jurkat,T
R6382 T7890 T7891 compound T,cells
R6383 T7891 T7888 pobj cells,in
R6384 T7892 T7868 punct .,suggest
R6385 T7893 T7895 det The,factor
R6386 T7894 T7895 compound transcription,factor
R6387 T7895 T7897 nsubj factor,is
R6388 T7896 T7897 nsubj NF-κB,is
R6389 T7897 T7897 ROOT is,is
R6390 T7898 T7897 acomp responsible,is
R6391 T7899 T7898 prep for,responsible
R6392 T7900 T7903 det a,response
R6393 T7901 T7903 amod rapid,response
R6394 T7902 T7903 amod immune,response
R6395 T7903 T7899 pobj response,for
R6396 T7904 T7906 nsubjpass which,followed
R6397 T7905 T7906 auxpass is,followed
R6398 T7906 T7903 relcl followed,response
R6399 T7907 T7906 agent by,followed
R6400 T7908 T7909 det an,increase
R6401 T7909 T7907 pobj increase,by
R6402 T7910 T7909 prep in,increase
R6403 T7911 T7910 pobj transcription,in
R6404 T7912 T7911 prep of,transcription
R6405 T7913 T7912 pobj IκB,of
R6406 T7914 T7915 advmod thus,inhibiting
R6407 T7915 T7897 advcl inhibiting,is
R6408 T7916 T7917 compound NF-κB,[
R6409 T7917 T7915 dobj [,inhibiting
R6410 T7918 T7919 nummod 46,]
R6411 T7919 T7917 appos ],[
R6412 T7920 T7897 punct .,is
R6413 T7921 T7927 nsubj Activation,is
R6414 T7922 T7921 prep of,Activation
R6415 T7923 T7922 pobj NF-κB,of
R6416 T7924 T7921 prep in,Activation
R6417 T7925 T7926 compound Jurkat,T-cells
R6418 T7926 T7924 pobj T-cells,in
R6419 T7927 T7927 ROOT is,is
R6420 T7928 T7927 acomp dependent,is
R6421 T7929 T7928 prep on,dependent
R6422 T7930 T7931 amod Bcl10,activation
R6423 T7931 T7929 pobj activation,on
R6424 T7932 T7931 punct ",",activation
R6425 T7933 T7937 nsubjpass which,regulated
R6426 T7934 T7937 prep in,regulated
R6427 T7935 T7934 pobj turn,in
R6428 T7936 T7937 auxpass is,regulated
R6429 T7937 T7931 relcl regulated,activation
R6430 T7938 T7937 agent by,regulated
R6431 T7939 T7938 pobj PKC,by
R6432 T7940 T7927 punct .,is
R6433 T7941 T7942 amod Recent,studies
R6434 T7942 T7944 nsubj studies,established
R6435 T7943 T7944 aux have,established
R6436 T7944 T7944 ROOT established,established
R6437 T7945 T7946 det the,importance
R6438 T7946 T7944 dobj importance,established
R6439 T7947 T7946 prep of,importance
R6440 T7948 T7949 det a,protein
R6441 T7949 T7947 pobj protein,of
R6442 T7950 T7951 amod complex,consisting
R6443 T7951 T7949 acl consisting,protein
R6444 T7952 T7951 prep of,consisting
R6445 T7953 T7952 pobj CARMA1,of
R6446 T7954 T7953 punct ",",CARMA1
R6447 T7955 T7953 conj Bcl10,CARMA1
R6448 T7956 T7955 cc and,Bcl10
R6449 T7957 T7955 conj MALT1,Bcl10
R6450 T7958 T7959 punct (,CBM
R6451 T7959 T7957 appos CBM,MALT1
R6452 T7960 T7957 punct ),MALT1
R6453 T7961 T7944 punct ",",established
R6454 T7962 T7944 prep in,established
R6455 T7963 T7964 det the,induction
R6456 T7964 T7962 pobj induction,in
R6457 T7965 T7964 prep of,induction
R6458 T7966 T7965 pobj NF-κB,of
R6459 T7967 T7944 punct .,established
R6460 T7968 T7977 advcl Investigating,demonstrated
R6461 T7969 T7968 dobj Bcl10,Investigating
R6462 T7970 T7969 punct ",",Bcl10
R6463 T7971 T7969 conj Scharschmidt,Bcl10
R6464 T7972 T7971 cc and,Scharschmidt
R6465 T7973 T7971 conj colleagues,Scharschmidt
R6466 T7974 T7976 compound [,]
R6467 T7975 T7976 nummod 47,]
R6468 T7976 T7973 appos ],colleagues
R6469 T7977 T7977 ROOT demonstrated,demonstrated
R6470 T7978 T7980 mark that,is
R6471 T7979 T7980 nsubj it,is
R6472 T7980 T7977 ccomp is,demonstrated
R6473 T7981 T7983 det a,regulator
R6474 T7982 T7983 amod critical,regulator
R6475 T7983 T7980 attr regulator,is
R6476 T7984 T7983 prep of,regulator
R6477 T7985 T7986 amod NF-κB,activity
R6478 T7986 T7984 pobj activity,of
R6479 T7987 T7977 punct .,demonstrated
R6480 T8085 T8082 conj activates,phosphorylates
R6481 T8086 T8085 dobj Bcl10,activates
R6482 T8087 T8082 punct .,phosphorylates
R6483 T8088 T8089 det These,studies
R6484 T8089 T8090 nsubj studies,indicate
R6485 T8090 T8090 ROOT indicate,indicate
R6486 T8091 T8093 mark that,is
R6487 T8092 T8093 nsubj PKC,is
R6488 T8093 T8090 ccomp is,indicate
R6489 T8094 T8093 acomp crucial,is
R6490 T8095 T8094 prep for,crucial
R6491 T8096 T8097 amod NF-κB,activation
R6492 T8097 T8095 pobj activation,for
R6493 T7988 T7999 nsubj Down-regulation,resulted
R6494 T8098 T8097 prep following,activation
R6495 T7989 T7988 prep of,Down-regulation
R6496 T8099 T8100 amod short-term,treatment
R6497 T7990 T7989 pobj Bcl10,of
R6498 T8100 T8098 pobj treatment,following
R6499 T7991 T7988 prep from,Down-regulation
R6500 T7992 T7991 pobj signals,from
R6501 T7993 T7992 acl transduced,signals
R6502 T8101 T8093 prep through,is
R6503 T7994 T7988 prep via,Down-regulation
R6504 T7995 T7996 det the,TCR/CD28
R6505 T8102 T8101 pobj signals,through
R6506 T7996 T7994 pobj TCR/CD28,via
R6507 T7997 T7996 cc and,TCR/CD28
R6508 T7998 T7999 nsubj PKC,resulted
R6509 T8103 T8102 prep via,signals
R6510 T7999 T7999 ROOT resulted,resulted
R6511 T8000 T7999 prep in,resulted
R6512 T8001 T8003 det a,down-regulation
R6513 T8002 T8003 amod concomitant,down-regulation
R6514 T8104 T8106 nmod membrane,receptors
R6515 T8003 T8000 pobj down-regulation,in
R6516 T8004 T8003 prep of,down-regulation
R6517 T8005 T8004 pobj NF-κB,of
R6518 T8105 T8106 amod bound,receptors
R6519 T8006 T7999 punct .,resulted
R6520 T8007 T8008 nsubj They,suggested
R6521 T8106 T8103 pobj receptors,via
R6522 T8008 T8008 ROOT suggested,suggested
R6523 T8009 T8013 mark that,activated
R6524 T8010 T8013 nsubjpass Bcl10,activated
R6525 T8011 T8013 auxpass is,activated
R6526 T8012 T8013 advmod initially,activated
R6527 T8013 T8008 ccomp activated,suggested
R6528 T8014 T8013 agent by,activated
R6529 T8107 T8108 amod such,as
R6530 T8015 T8014 pobj TCR/PKC,by
R6531 T8016 T8013 cc but,activated
R6532 T8108 T8106 prep as,receptors
R6533 T8109 T8110 det the,TCR
R6534 T8017 T8025 mark that,promotes
R6535 T8110 T8108 pobj TCR,as
R6536 T8018 T8019 amod continued,activation
R6537 T8019 T8025 nsubj activation,promotes
R6538 T8020 T8021 punct (,>
R6539 T8021 T8023 nmod >,h
R6540 T8111 T8110 cc and,TCR
R6541 T8022 T8021 nummod 1,>
R6542 T8023 T8019 appos h,activation
R6543 T8024 T8019 punct ),activation
R6544 T8025 T8008 ccomp promotes,suggested
R6545 T8026 T8027 poss its,degradation
R6546 T8112 T8114 det the,receptor
R6547 T8027 T8025 dobj degradation,promotes
R6548 T8028 T8008 punct .,suggested
R6549 T8029 T8035 nsubj Narayan,suggested
R6550 T8113 T8114 amod co-stimulatory,receptor
R6551 T8030 T8029 cc and,Narayan
R6552 T8031 T8029 conj colleagues,Narayan
R6553 T8032 T8034 compound [,]
R6554 T8033 T8034 compound 27,]
R6555 T8034 T8031 appos ],colleagues
R6556 T8114 T8115 compound receptor,CD28
R6557 T8035 T8035 ROOT suggested,suggested
R6558 T8036 T8046 mark that,impairs
R6559 T8037 T8046 nsubj deletion,impairs
R6560 T8038 T8037 prep in,deletion
R6561 T8115 T8110 conj CD28,TCR
R6562 T8039 T8038 pobj any,in
R6563 T8040 T8039 prep of,any
R6564 T8041 T8045 det the,proteins
R6565 T8116 T8090 punct .,indicate
R6566 T8042 T8045 nummod three,proteins
R6567 T8043 T8045 nmod CBM,proteins
R6568 T8044 T8045 amod complex,proteins
R6569 T8117 T8123 advmod Thus,play
R6570 T8045 T8040 pobj proteins,of
R6571 T8046 T8035 ccomp impairs,suggested
R6572 T8118 T8123 punct ",",play
R6573 T8047 T8049 amod antigen-receptor,activation
R6574 T8048 T8049 amod dependent,activation
R6575 T8049 T8046 dobj activation,impairs
R6576 T8050 T8049 prep of,activation
R6577 T8051 T8050 pobj NF-κB,of
R6578 T8052 T8035 punct .,suggested
R6579 T8119 T8122 det the,proteins
R6580 T8053 T8054 nsubj They,showed
R6581 T8054 T8054 ROOT showed,showed
R6582 T8055 T8060 mark that,requires
R6583 T8120 T8122 nmod CBM,proteins
R6584 T8056 T8057 amod NF-κB,activation
R6585 T8057 T8060 nsubj activation,requires
R6586 T8058 T8057 prep via,activation
R6587 T8121 T8122 amod complex,proteins
R6588 T8122 T8123 nsubj proteins,play
R6589 T8123 T8123 ROOT play,play
R6590 T8059 T8058 pobj Akt,via
R6591 T8060 T8054 ccomp requires,showed
R6592 T8124 T8126 det a,role
R6593 T8061 T8060 dobj CARMA1,requires
R6594 T8062 T8061 cc and,CARMA1
R6595 T8125 T8126 amod key,role
R6596 T8063 T8061 conj acts,CARMA1
R6597 T8064 T8063 prep in,acts
R6598 T8126 T8123 dobj role,play
R6599 T8065 T8064 pobj cooperation,in
R6600 T8066 T8065 prep with,cooperation
R6601 T8067 T8068 nsubj PKC,following
R6602 T8127 T8123 prep in,play
R6603 T8068 T8066 pcomp following,with
R6604 T8069 T8070 amod short-term,exposure
R6605 T8128 T8130 det this,process
R6606 T8070 T8068 dobj exposure,following
R6607 T8071 T8073 punct (,min
R6608 T8129 T8130 amod signalling,process
R6609 T8072 T8073 nummod 30,min
R6610 T8073 T8070 appos min,exposure
R6611 T8074 T8063 punct ),acts
R6612 T8075 T8061 prep of,CARMA1
R6613 T8130 T8127 pobj process,in
R6614 T8076 T8077 compound Jurkat,T-cells
R6615 T8077 T8075 pobj T-cells,of
R6616 T8131 T8123 punct .,play
R6617 T8078 T8060 prep with,requires
R6618 T8079 T8078 pobj PMA,with
R6619 T8080 T8054 punct .,showed
R6620 T8132 T8133 nsubj PMA,diffuses
R6621 T8081 T8082 compound Akt,phosphorylates
R6622 T8082 T8082 ROOT phosphorylates,phosphorylates
R6623 T8083 T8082 cc and,phosphorylates
R6624 T8084 T8085 advmod thus,activates
R6625 T8133 T8133 ROOT diffuses,diffuses
R6626 T8134 T8133 prep into,diffuses
R6627 T8135 T8136 det the,cytosol
R6628 T8136 T8134 pobj cytosol,into
R6629 T8137 T8133 cc and,diffuses
R6630 T8182 T8182 ROOT activated,activated
R6631 T8138 T8139 advmod directly,activates
R6632 T8183 T8182 prep at,activated
R6633 T8184 T8186 det an,stage
R6634 T8139 T8133 conj activates,diffuses
R6635 T8185 T8186 amod early,stage
R6636 T8186 T8183 pobj stage,at
R6637 T8187 T8182 prep following,activated
R6638 T8140 T8139 dobj PKC,activates
R6639 T8188 T8189 compound T-cell,stimulation
R6640 T8189 T8187 pobj stimulation,following
R6641 T8190 T8182 cc and,activated
R6642 T8141 T8143 mark since,is
R6643 T8191 T8182 conj is,activated
R6644 T8192 T8191 advmod therefore,is
R6645 T8142 T8143 nsubj it,is
R6646 T8143 T8139 advcl is,activates
R6647 T8193 T8195 det an,regulator
R6648 T8144 T8145 det an,analogue
R6649 T8145 T8143 attr analogue,is
R6650 T8194 T8195 amod important,regulator
R6651 T8146 T8147 aux to,diacylglycerol
R6652 T8195 T8191 attr regulator,is
R6653 T8147 T8145 acl diacylglycerol,analogue
R6654 T8148 T8150 nmod [,]
R6655 T8196 T8195 prep of,regulator
R6656 T8149 T8150 nummod 48,]
R6657 T8150 T8147 dobj ],diacylglycerol
R6658 T8197 T8200 amod downstream,pathways
R6659 T8151 T8133 punct .,diffuses
R6660 T8152 T8153 amod Several,studies
R6661 T8198 T8199 amod inflammatory,signalling
R6662 T8153 T8155 nsubj studies,demonstrated
R6663 T8154 T8155 aux have,demonstrated
R6664 T8199 T8200 amod signalling,pathways
R6665 T8155 T8155 ROOT demonstrated,demonstrated
R6666 T8200 T8196 pobj pathways,of
R6667 T8156 T8157 det that,inhibition
R6668 T8201 T8200 acl leading,pathways
R6669 T8157 T8155 dobj inhibition,demonstrated
R6670 T8158 T8157 prep of,inhibition
R6671 T8202 T8201 prep to,leading
R6672 T8203 T8204 compound cytokine,expression
R6673 T8204 T8202 pobj expression,to
R6674 T8205 T8204 dobj [,expression
R6675 T8159 T8160 compound PKC,blocks
R6676 T8206 T8207 nummod 50,]
R6677 T8207 T8204 dobj ],expression
R6678 T8208 T8191 punct .,is
R6679 T8209 T8211 nsubj We,shown
R6680 T8160 T8158 pobj blocks,of
R6681 T8210 T8211 aux have,shown
R6682 T8211 T8211 ROOT shown,shown
R6683 T8161 T8164 nmod NF-κB,activity
R6684 T8212 T8216 mark that,regulated
R6685 T8213 T8216 nsubjpass phosphorylated-PKC,regulated
R6686 T8214 T8216 auxpass is,regulated
R6687 T8162 T8161 cc and,NF-κB
R6688 T8215 T8216 advmod up,regulated
R6689 T8216 T8211 ccomp regulated,shown
R6690 T8217 T8216 prep in,regulated
R6691 T8163 T8164 amod AP-1,activity
R6692 T8218 T8217 pobj response,in
R6693 T8219 T8218 prep to,response
R6694 T8220 T8224 nmod PMA,coli
R6695 T8164 T8157 conj activity,inhibition
R6696 T8221 T8220 cc and,PMA
R6697 T8222 T8224 compound HK,coli
R6698 T8165 T8157 punct ",",inhibition
R6699 T8223 T8224 compound E.,coli
R6700 T8224 T8219 pobj coli,to
R6701 T8225 T8216 punct ",",regulated
R6702 T8226 T8216 advcl indicating,regulated
R6703 T8166 T8157 acl suggesting,inhibition
R6704 T8227 T8228 det an,association
R6705 T8228 T8226 dobj association,indicating
R6706 T8167 T8169 det a,regulation
R6707 T8229 T8228 prep between,association
R6708 T8168 T8169 amod direct,regulation
R6709 T8230 T8229 pobj PKC,between
R6710 T8231 T8230 cc and,PKC
R6711 T8169 T8166 dobj regulation,suggesting
R6712 T8232 T8234 det the,factors
R6713 T8233 T8234 compound transcription,factors
R6714 T8170 T8169 prep of,regulation
R6715 T8234 T8230 conj factors,PKC
R6716 T8235 T8234 appos AP-1,factors
R6717 T8236 T8235 cc and,AP-1
R6718 T8171 T8173 det these,factors
R6719 T8237 T8235 conj NF-κB,AP-1
R6720 T8238 T8211 punct .,shown
R6721 T8239 T8240 amod Bcl10,levels
R6722 T8172 T8173 compound transcription,factors
R6723 T8240 T8241 nsubj levels,were
R6724 T8241 T8241 ROOT were,were
R6725 T8242 T8241 acomp down-regulated,were
R6726 T8243 T8241 prep following,were
R6727 T8244 T8245 amod extended,treatment
R6728 T8245 T8243 dobj treatment,following
R6729 T8173 T8170 pobj factors,of
R6730 T8246 T8245 prep of,treatment
R6731 T8247 T8248 compound Jurkat,T-cells
R6732 T8248 T8246 pobj T-cells,of
R6733 T8174 T8169 prep by,regulation
R6734 T8249 T8245 prep with,treatment
R6735 T8250 T8249 pobj PMA,with
R6736 T8251 T8241 punct .,were
R6737 T8175 T8176 compound PKC,[
R6738 T8252 T8261 prep In,occurred
R6739 T8253 T8255 det the,groups
R6740 T8254 T8255 compound control,groups
R6741 T8176 T8174 pobj [,by
R6742 T8255 T8252 pobj groups,In
R6743 T8256 T8261 punct ",",occurred
R6744 T8257 T8258 det a,loss
R6745 T8177 T8178 nummod "49,50",]
R6746 T8258 T8261 nsubj loss,occurred
R6747 T8259 T8258 prep of,loss
R6748 T8260 T8259 pobj Bcl10,of
R6749 T8178 T8176 appos ],[
R6750 T8261 T8261 ROOT occurred,occurred
R6751 T8262 T8261 prep after,occurred
R6752 T8263 T8264 nummod 6,h
R6753 T8179 T8155 punct .,demonstrated
R6754 T8264 T8262 pobj h,after
R6755 T8265 T8264 punct ",",h
R6756 T8266 T8261 advcl followed,occurred
R6757 T8180 T8182 nsubjpass PKC,activated
R6758 T8267 T8266 agent by,followed
R6759 T8268 T8269 det an,increase
R6760 T8269 T8267 pobj increase,by
R6761 T8181 T8182 auxpass is,activated
R6762 T8270 T8269 prep after,increase
R6763 T8271 T8272 nummod 24,h
R6764 T8272 T8270 pobj h,after
R6765 T8279 T8282 det the,activity
R6766 T8273 T8272 punct ",",h
R6767 T8274 T8275 nsubj which,is
R6768 T8275 T8272 relcl is,h
R6769 T8280 T8282 amod observed,activity
R6770 T8276 T8275 prep in,is
R6771 T8277 T8276 pobj accordance,in
R6772 T8278 T8277 prep with,accordance
R6773 T8281 T8282 compound NF-κB,activity
R6774 T8282 T8278 pobj activity,with
R6775 T8283 T8284 punct (,figure
R6776 T8376 T8377 compound inflammation,result
R6777 T8284 T8282 appos figure,activity
R6778 T8377 T8374 pobj result,during
R6779 T8378 T8377 prep in,result
R6780 T8379 T8381 det an,recruitment
R6781 T8285 T8284 nummod 7,figure
R6782 T8380 T8381 amod enhanced,recruitment
R6783 T8381 T8378 pobj recruitment,in
R6784 T8382 T8381 prep of,recruitment
R6785 T8286 T8282 punct ),activity
R6786 T8383 T8384 amod immune,cells
R6787 T8384 T8382 pobj cells,of
R6788 T8385 T8381 prep to,recruitment
R6789 T8287 T8261 punct .,occurred
R6790 T8386 T8387 det the,site
R6791 T8387 T8385 pobj site,to
R6792 T8288 T8289 det These,results
R6793 T8388 T8387 prep of,site
R6794 T8289 T8291 nsubjpass results,supported
R6795 T8290 T8291 auxpass are,supported
R6796 T8389 T8388 pobj infection,of
R6797 T8390 T8387 punct ",",site
R6798 T8391 T8393 nsubj which,lead
R6799 T8291 T8291 ROOT supported,supported
R6800 T8392 T8393 aux may,lead
R6801 T8393 T8387 relcl lead,site
R6802 T8292 T8291 agent by,supported
R6803 T8394 T8393 prep to,lead
R6804 T8395 T8396 det the,development
R6805 T8396 T8394 pobj development,to
R6806 T8293 T8295 det an,study
R6807 T8397 T8396 prep of,development
R6808 T8294 T8295 amod earlier,study
R6809 T8398 T8399 amod autoimmune,diseases
R6810 T8399 T8397 pobj diseases,of
R6811 T8400 T8399 acl following,diseases
R6812 T8295 T8292 pobj study,by
R6813 T8401 T8400 dobj secretion,following
R6814 T8402 T8401 prep of,secretion
R6815 T8296 T8298 nmod [,]
R6816 T8403 T8404 amod pro-inflammatory,cytokines
R6817 T8404 T8402 pobj cytokines,of
R6818 T8297 T8298 nummod 47,]
R6819 T8405 T8373 punct .,levels
R6820 T8406 T8415 prep In,elevated
R6821 T8407 T8409 nmod HIV,persons
R6822 T8298 T8295 appos ],study
R6823 T8408 T8409 amod infected,persons
R6824 T8409 T8406 pobj persons,In
R6825 T8410 T8415 punct ",",elevated
R6826 T8411 T8413 compound serum,levels
R6827 T8412 T8413 compound CXCL8,levels
R6828 T8413 T8415 nsubjpass levels,elevated
R6829 T8299 T8295 punct ",",study
R6830 T8414 T8415 auxpass are,elevated
R6831 T8415 T8415 ROOT elevated,elevated
R6832 T8416 T8415 cc and,elevated
R6833 T8300 T8295 acl demonstrating,study
R6834 T8417 T8419 nsubj this,recruit
R6835 T8418 T8419 aux could,recruit
R6836 T8419 T8415 conj recruit,elevated
R6837 T8301 T8307 mark that,leads
R6838 T8420 T8421 amod more,T-cells
R6839 T8421 T8419 dobj T-cells,recruit
R6840 T8422 T8423 advmod potentially,leading
R6841 T8302 T8304 amod prolonged,activation
R6842 T8423 T8419 advcl leading,recruit
R6843 T8424 T8423 prep to,leading
R6844 T8303 T8304 compound PKC,activation
R6845 T8425 T8428 det a,progression
R6846 T8426 T8427 advmod more,rapid
R6847 T8304 T8307 nsubj activation,leads
R6848 T8305 T8304 prep by,activation
R6849 T8427 T8428 amod rapid,progression
R6850 T8306 T8305 pobj PMA,by
R6851 T8307 T8300 ccomp leads,demonstrating
R6852 T8308 T8307 prep to,leads
R6853 T8428 T8424 pobj progression,to
R6854 T8309 T8310 det an,inhibition
R6855 T8429 T8428 prep of,progression
R6856 T8430 T8431 det the,disease
R6857 T8431 T8429 pobj disease,of
R6858 T8310 T8308 pobj inhibition,to
R6859 T8432 T8435 mark since,be
R6860 T8433 T8435 expl there,be
R6861 T8434 T8435 aux will,be
R6862 T8435 T8419 advcl be,recruit
R6863 T8311 T8310 prep of,inhibition
R6864 T8436 T8437 amod more,T-cells
R6865 T8437 T8435 attr T-cells,be
R6866 T8438 T8437 amod available,T-cells
R6867 T8312 T8311 pobj Bcl10,of
R6868 T8439 T8440 aux to,infect
R6869 T8440 T8438 xcomp infect,available
R6870 T8313 T8312 cc and,Bcl10
R6871 T8441 T8419 punct .,recruit
R6872 T8314 T8312 conj NF-κB,Bcl10
R6873 T8315 T8291 punct .,supported
R6874 T8316 T8319 nsubjpass It,shown
R6875 T8317 T8319 aux has,shown
R6876 T8318 T8319 auxpass been,shown
R6877 T8319 T8319 ROOT shown,shown
R6878 T8320 T8322 mark that,is
R6879 T8321 T8322 nsubj NF-κB,is
R6884 T8322 T8319 ccomp is,shown
R6889 T8323 T8326 det an,factor
R6892 T8324 T8326 amod important,factor
R6897 T8325 T8326 compound transcription,factor
R6900 T8326 T8327 compound factor,complex
R6903 T8327 T8322 attr complex,is
R6904 T8328 T8327 amod involved,complex
R6907 T8329 T8328 prep in,involved
R6914 T8330 T8331 advmod almost,every
R6915 T8331 T8332 nummod every,aspect
R6928 T8332 T8329 pobj aspect,in
R6933 T8333 T8332 prep of,aspect
R6939 T8334 T8335 compound cell,regulation
R6943 T8335 T8333 pobj regulation,of
R6944 T8336 T8335 prep including,regulation
R6949 T8337 T8336 pobj apoptosis,including
R6950 T8338 T8337 punct ",",apoptosis
R6951 T8339 T8337 conj differentiation,apoptosis
R6953 T8340 T8339 punct ",",differentiation
R6960 T8341 T8339 conj proliferation,differentiation
R6961 T8342 T8341 cc and,proliferation
R6966 T8343 T8341 conj initiation,proliferation
R6967 T8344 T8337 prep of,apoptosis
R6971 T8345 T8346 amod immune,responses
R6973 T8346 T8344 pobj responses,of
R6974 T8347 T8349 compound [,]
R6977 T8348 T8349 compound 51-53,]
R6986 T8349 T8337 appos ],apoptosis
R6989 T8350 T8319 punct .,shown
R6991 T8351 T8352 nsubj NF-κB,is
R7000 T8352 T8352 ROOT is,is
R7004 T8353 T8354 advmod constitutively,active
R7007 T8354 T8352 acomp active,is
R7008 T8355 T8354 prep in,active
R7017 T8356 T8358 amod many,malignancies
R7019 T8357 T8358 amod human,malignancies
R7024 T8358 T8355 pobj malignancies,in
R7032 T8359 T8358 punct ",",malignancies
R7036 T8360 T8361 nsubj which,makes
R7040 T8361 T8352 advcl makes,is
R7042 T8362 T8366 nsubj it,target
R7046 T8363 T8366 det an,target
R7050 T8364 T8366 amod attractive,target
R7056 T8365 T8366 amod therapeutic,target
R7059 T8366 T8361 ccomp target,makes
R7060 T8367 T8366 appos [,target
R7064 T8368 T8369 nummod 54,]
R7067 T8369 T8366 appos ],target
R7069 T8370 T8352 punct .,is
R7072 T8371 T8373 amod Elevated,levels
R7081 T8372 T8373 compound CXCL8,levels
R7085 T8373 T8373 ROOT levels,levels
R7091 T8374 T8373 prep during,levels
R7095 T8375 T8377 amod chronic,result
R5658 T7166 T7165 pcomp obtaining,by
R5659 T7167 T7166 dobj expression,obtaining
R5660 T7168 T7167 prep of,expression
R5661 T7169 T7168 pobj IL-6,of
R5662 T7170 T7166 prep following,obtaining
R5663 T7171 T7172 det the,exposure
R5664 T7172 T7170 pobj exposure,following
R5665 T7173 T7172 prep of,exposure
R5666 T7174 T7173 pobj T-cells,of
R5667 T7175 T7176 aux to,peptidoglycan
R5668 T7176 T7172 acl peptidoglycan,exposure
R5669 T7177 T7160 punct .,reported
R5670 T7178 T7190 nsubj Reduction,be
R5671 T7179 T7178 prep in,Reduction
R5672 T7180 T7179 pobj NF-κB,in
R5673 T7181 T7178 prep by,Reduction
R5674 T7182 T7183 compound calcium,ionophore
R5675 T7183 T7181 pobj ionophore,by
R5676 T7184 T7178 prep following,Reduction
R5677 T7185 T7188 compound HK,stimulation
R5678 T7186 T7188 compound E.,stimulation
R5679 T7187 T7188 compound coli,stimulation
R5680 T7188 T7184 dobj stimulation,following
R5681 T7189 T7190 aux may,be
R5682 T7190 T7190 ROOT be,be
R6149 T7657 T7654 dobj role,play
R6150 T7658 T7654 prep in,play
R6151 T7659 T7660 det the,induction

UBERON-AE

Id Subject Object Predicate Lexical cue
T6702 8642-8647 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

GO-BP

Id Subject Object Predicate Lexical cue
T10073 53-75 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10074 819-841 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10075 2120-2142 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10076 2498-2520 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10077 3374-3396 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10078 4278-4300 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T10079 8420-8432 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T10080 95-121 http://purl.obolibrary.org/obo/GO_0002572 denotes differentiation of T-cells
T10081 95-121 http://purl.obolibrary.org/obo/GO_0045580 denotes differentiation of T-cells
T10082 95-121 http://purl.obolibrary.org/obo/GO_0001865 denotes differentiation of T-cells
T10083 95-121 http://purl.obolibrary.org/obo/GO_0030217 denotes differentiation of T-cells
T10084 95-121 http://purl.obolibrary.org/obo/GO_0042093 denotes differentiation of T-cells
T10085 95-121 http://purl.obolibrary.org/obo/GO_0045066 denotes differentiation of T-cells
T10086 95-121 http://purl.obolibrary.org/obo/GO_0043379 denotes differentiation of T-cells
T10087 144-150 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T10088 621-631 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T10089 6995-7005 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T10090 6995-7013 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling process
T10091 144-163 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T10092 621-640 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T10093 7418-7437 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T10094 151-163 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T10095 297-307 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10096 994-1004 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10097 1819-1829 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10098 2389-2399 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10099 3718-3728 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10100 4931-4941 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10101 5526-5536 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10102 6150-6160 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10103 6250-6260 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10104 7229-7239 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10105 8163-8173 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10106 426-448 http://purl.obolibrary.org/obo/GO_0000187 denotes activation of the MAPK
T10107 444-448 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10108 597-601 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10109 4188-4192 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10110 4407-4411 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10111 511-532 http://purl.obolibrary.org/obo/GO_0051132 denotes activation in T-cells
T10112 780-797 http://purl.obolibrary.org/obo/GO_0051132 denotes T-cell activation
T10113 3241-3258 http://purl.obolibrary.org/obo/GO_0051132 denotes T-cell activation
T10114 511-532 http://purl.obolibrary.org/obo/GO_0042110 denotes activation in T-cells
T10115 780-797 http://purl.obolibrary.org/obo/GO_0042110 denotes T-cell activation
T10116 3241-3258 http://purl.obolibrary.org/obo/GO_0042110 denotes T-cell activation
T10117 511-532 http://purl.obolibrary.org/obo/GO_0050798 denotes activation in T-cells
T10118 780-797 http://purl.obolibrary.org/obo/GO_0050798 denotes T-cell activation
T10119 3241-3273 http://purl.obolibrary.org/obo/GO_0050798 denotes T-cell activation, proliferation
T10120 511-532 http://purl.obolibrary.org/obo/GO_0050863 denotes activation in T-cells
T10121 780-797 http://purl.obolibrary.org/obo/GO_0050863 denotes T-cell activation
T10122 3241-3258 http://purl.obolibrary.org/obo/GO_0050863 denotes T-cell activation
T10123 511-532 http://purl.obolibrary.org/obo/GO_1903905 denotes activation in T-cells
T10124 780-797 http://purl.obolibrary.org/obo/GO_1903905 denotes T-cell activation
T10125 3241-3258 http://purl.obolibrary.org/obo/GO_1903905 denotes T-cell activation
T10126 676-691 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T10127 2272-2285 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10128 4209-4222 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10129 5625-5638 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10130 5731-5744 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10131 7249-7262 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10132 7610-7623 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10133 8094-8107 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10134 780-815 http://purl.obolibrary.org/obo/GO_0070266 denotes T-cell activation and the induction
T10135 782-797 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T10136 3243-3258 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T10137 1297-1300 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10138 2232-2235 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10139 3890-3893 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10140 4108-4111 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10141 4945-4948 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10142 5009-5012 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10143 5357-5360 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10144 5882-5885 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10145 6215-6218 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10146 6327-6330 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10147 6630-6633 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10148 6774-6777 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10149 7068-7071 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10150 7173-7176 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10151 7274-7277 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10152 7287-7290 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10153 7509-7512 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10154 7598-7601 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10155 7984-7987 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10156 1311-1322 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10157 6381-6392 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10158 1348-1363 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T10159 7532-7547 http://purl.obolibrary.org/obo/GO_1904627 denotes response to PMA
T10160 1412-1428 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10161 3676-3692 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10162 3968-3984 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10163 4425-4441 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10164 6560-6576 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10165 6793-6809 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10166 1644-1653 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T10167 2232-2246 http://purl.obolibrary.org/obo/GO_1990051 denotes PKC activation
T10168 7984-7998 http://purl.obolibrary.org/obo/GO_1990051 denotes PKC activation
T10169 2566-2581 http://purl.obolibrary.org/obo/GO_0010467 denotes gene-expression
T10170 5048-5063 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T10171 2610-2625 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T10172 5679-5694 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T10173 8244-8260 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T10174 2943-2954 http://purl.obolibrary.org/obo/GO_0004722 denotes calcineurin
T10175 2943-2954 http://purl.obolibrary.org/obo/GO_0004723 denotes calcineurin
T10176 3241-3273 http://purl.obolibrary.org/obo/GO_0046006 denotes T-cell activation, proliferation
T10177 3243-3273 http://purl.obolibrary.org/obo/GO_0001938 denotes cell activation, proliferation
T10178 3243-3273 http://purl.obolibrary.org/obo/GO_0008284 denotes cell activation, proliferation
T10179 3243-3273 http://purl.obolibrary.org/obo/GO_0032946 denotes cell activation, proliferation
T10180 3243-3273 http://purl.obolibrary.org/obo/GO_1902724 denotes cell activation, proliferation
T10181 3243-3273 http://purl.obolibrary.org/obo/GO_1904699 denotes cell activation, proliferation
T10182 3243-3273 http://purl.obolibrary.org/obo/GO_0002053 denotes cell activation, proliferation
T10183 3243-3273 http://purl.obolibrary.org/obo/GO_0050677 denotes cell activation, proliferation
T10184 3243-3273 http://purl.obolibrary.org/obo/GO_0070346 denotes cell activation, proliferation
T10185 3243-3273 http://purl.obolibrary.org/obo/GO_1904443 denotes cell activation, proliferation
T10186 3409-3422 http://purl.obolibrary.org/obo/GO_0002667 denotes T-cell anergy
T10187 3409-3422 http://purl.obolibrary.org/obo/GO_0002870 denotes T-cell anergy
T10188 4425-4451 http://purl.obolibrary.org/obo/GO_1903721 denotes NF-κB activation inhibitor
T10189 4518-4533 http://purl.obolibrary.org/obo/GO_1900165 denotes IL-6 inhibition
T10190 4931-4948 http://purl.obolibrary.org/obo/GO_1900019 denotes regulation by PKC
T10191 4954-4957 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T10192 5017-5020 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T10193 5207-5210 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T10194 5521-5536 http://purl.obolibrary.org/obo/GO_0032675 denotes IL-6 regulation
T10195 5521-5536 http://purl.obolibrary.org/obo/GO_0045408 denotes IL-6 regulation
T10196 5757-5773 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibiting NF-κB
T10197 5757-5773 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibiting NF-κB
T10198 6202-6205 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10199 6323-6326 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10200 6898-6901 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10201 7229-7270 http://purl.obolibrary.org/obo/GO_1901483 denotes regulation of these transcription factors
T10202 7229-7270 http://purl.obolibrary.org/obo/GO_0051090 denotes regulation of these transcription factors
T10203 7332-7350 http://purl.obolibrary.org/obo/GO_0031295 denotes T-cell stimulation
T10204 8184-8193 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T10205 8184-8193 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T10206 8531-8542 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T10207 8576-8585 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion

GO-MF

Id Subject Object Predicate Lexical cue
T10208 282-286 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10209 1557-1561 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10210 2004-2008 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10211 2347-2351 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10212 2551-2555 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10213 2732-2736 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10214 3765-3769 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10215 4518-4522 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10216 4579-4583 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10217 5521-5525 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10218 444-448 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10219 597-601 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10220 4188-4192 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10221 4407-4411 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10222 1297-1300 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10223 2232-2235 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10224 3890-3893 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10225 4108-4111 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10226 4945-4948 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10227 5009-5012 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10228 5357-5360 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10229 5882-5885 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10230 6215-6218 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10231 6327-6330 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10232 6630-6633 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10233 6774-6777 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10234 7068-7071 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10235 7173-7176 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10236 7274-7277 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10237 7287-7290 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10238 7509-7512 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10239 7598-7601 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10240 7984-7987 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T10241 1644-1653 http://purl.obolibrary.org/obo/GO_0022809 denotes ionophore
T10242 1710-1717 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10243 2305-2312 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10244 1710-1725 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T10245 1998-2002 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10246 2174-2178 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10247 3332-3336 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10248 3992-3996 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10249 4054-4058 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10250 4137-4141 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10251 2025-2030 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10252 3044-3049 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10253 3166-3171 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10254 3215-3220 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10255 2943-2954 http://purl.obolibrary.org/obo/GO_0004722 denotes calcineurin
T10256 2943-2954 http://purl.obolibrary.org/obo/GO_0004723 denotes calcineurin
T10257 3338-3342 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T10258 4954-4957 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T10259 5017-5020 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T10260 5207-5210 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T10280 5939-5954 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complex
T10281 6470-6486 http://purl.obolibrary.org/obo/GO_0043234 denotes complex proteins
T10282 6954-6970 http://purl.obolibrary.org/obo/GO_0043234 denotes complex proteins
T10283 6202-6205 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10284 6323-6326 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10261 116-121 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10262 338-343 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10263 527-532 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10264 646-651 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10265 1590-1595 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10266 1919-1924 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10267 2526-2531 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10268 2638-2643 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10269 2897-2902 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10270 3014-3019 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10271 4313-4318 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10272 5614-5619 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10273 5812-5817 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10274 6685-6690 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10275 7722-7727 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10276 8477-8482 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10277 8704-8709 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10278 8800-8805 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10279 1599-1612 http://purl.obolibrary.org/obo/GO_0009274 denotes peptidoglycan
T10285 6898-6901 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10286 6466-6477 http://purl.obolibrary.org/obo/GO_0032449 denotes CBM complex
T10287 6950-6961 http://purl.obolibrary.org/obo/GO_0032449 denotes CBM complex
T10288 6861-6869 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T10289 7037-7044 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T10290 8094-8122 http://purl.obolibrary.org/obo/GO_0030907 denotes transcription factor complex
T10291 8094-8122 http://purl.obolibrary.org/obo/GO_0035976 denotes transcription factor complex
T10292 8094-8122 http://purl.obolibrary.org/obo/GO_0005667 denotes transcription factor complex
T10293 8094-8122 http://purl.obolibrary.org/obo/GO_0005669 denotes transcription factor complex
T10294 8094-8122 http://purl.obolibrary.org/obo/GO_0005674 denotes transcription factor complex
T10295 8094-8122 http://purl.obolibrary.org/obo/GO_0044797 denotes transcription factor complex
T10296 8094-8122 http://purl.obolibrary.org/obo/GO_0000127 denotes transcription factor complex
T10297 8094-8122 http://purl.obolibrary.org/obo/GO_0034735 denotes transcription factor complex
T10298 8094-8122 http://purl.obolibrary.org/obo/GO_0000126 denotes transcription factor complex
T10299 8094-8122 http://purl.obolibrary.org/obo/GO_0005672 denotes transcription factor complex

sentences

Id Subject Object Predicate Lexical cue
T6844 11-233 Sentence denotes NF-κB and AP-1 are critical regulators of inflammatory responses, proliferation and differentiation of T-cells [28-30], however, the signal transduction and subsequent cytokine/chemokine expression is not fully understood.
T6845 234-344 Sentence denotes The aim of the present study was to investigate IL-6 and CXCL8 regulation by NF-κB and AP-1 in Jurkat T-cells.
T6846 345-457 Sentence denotes Our results demonstrated that PMA induced AP-1 activation, indicating a specific activation of the MAPK pathway.
T6847 458-596 Sentence denotes Furthermore, we demonstrated that PMA dependent AP-1 activation in T-cells was delayed (>2 h) and increased following long-term treatment.
T6848 597-711 Sentence denotes MAPK is one of the main signalling pathways in T-cells that regulate cell- and transcriptional activation [31,32].
T6849 712-892 Sentence denotes Several studies [20,33,34] have indicated the importance of AP-1 in T-cell activation and the induction of inflammatory responses [35], including pro-inflammatory cytokine release.
T6850 893-1033 Sentence denotes In contrast to AP-1, NF-κB activity rapidly increased (1 min) during PMA exposure followed by a down-regulation to the lowest levels at 6 h.
T6851 1034-1244 Sentence denotes This is in line with Park and colleagues [36] who demonstrated a rapid increase in NF-κB activity following short-term stimulation with PMA, but prolonged challenge resulted in a persistent inhibition of NF-κB.
T6852 1245-1364 Sentence denotes They showed that the inhibition of NF-κB was due to PKC-dependent degradation of IκB kinase β and γ in response to PMA.
T6853 1365-1461 Sentence denotes Interestingly, the HK E. coli exposure induced NF-κB activation without affecting AP-1 activity.
T6854 1462-1613 Sentence denotes Wang and colleagues [37] reported an elevated inflammatory response by obtaining expression of IL-6 following the exposure of T-cells to peptidoglycan.
T6855 1614-1814 Sentence denotes Reduction in NF-κB by calcium ionophore following HK E. coli stimulation may be due to the Ca2+ binding protein calmodulin (CaM), which has been shown to negatively regulate c-Rel when activated [38].
T6856 1815-1916 Sentence denotes The regulation of NF-κB and AP-1 observed in the present study was in agreement with earlier studies.
T6857 1917-2087 Sentence denotes T-cells produce a broad range of pro- and anti-inflammatory cytokines, including IL-2, IL-6, CXCL8, TNF and IL-10, in response to infections or other stress factors [39].
T6858 2088-2252 Sentence denotes The assessment of Jurkat T-cell inflammatory responses (Table 1) revealed an enhanced IL-2 expression upon exposure to PMA or HK E. coli due to PKC activation [40].
T6859 2253-2405 Sentence denotes In addition to the transcription factor NF-κB, AP-1 binding sites have been identified in the IL-6 promoter region, indicating multiple regulation [22].
T6860 2406-2537 Sentence denotes AP-1 and NF-κB have also been demonstrated to regulate CXCL8 expression during induction of inflammatory responses in T-cells [12].
T6861 2538-2649 Sentence denotes Furthermore, IL-6 and CXCL8 gene-expression is associated with an early immune response in Jurkat T-cells [41].
T6862 2650-2791 Sentence denotes In the present study, both PMA and HK E. coli resulted in comparable increases in IL-6 while PMA was more potent at activating CXCL8 release.
T6863 2792-2849 Sentence denotes PMA and HK E. coli treatment also induced TNF expression.
T6864 2850-2980 Sentence denotes TNF is one of the first cytokines induced by T-cells [42] and its expression is regulated by calcineurin, NFAT and ATF-2/Jun [20].
T6865 2981-3105 Sentence denotes However, PMA-stimulated Jurkat T-cells showed no difference in IL-10 expression indicating an induced inflammatory response.
T6866 3106-3183 Sentence denotes HK E. coli treatment resulted in a significant reduction of IL-10 expression.
T6867 3184-3428 Sentence denotes The anti-inflammatory cytokine IL-10 is known to inhibit T-cell activation, proliferation and the expression of pro-inflammatory cytokines, such as IL-2, IL-5 and INF-γ [39,43] and regulate inflammatory responses by inducing T-cell anergy [44].
T6868 3429-3621 Sentence denotes The time course analysis of cytokine expression showed a correlation between AP-1 and the chemokine CXCL8 where CXCL8 expression was significantly elevated already at 2-6 h after PMA exposure.
T6869 3622-3759 Sentence denotes The CXCL8 expression did not correlate with the early NF-κB activation (1 min) or with the down-regulation of NF-κB at 2 h post exposure.
T6870 3760-3822 Sentence denotes Both IL-6 and TNF expression were up regulated between 6-24 h.
T6871 3823-3889 Sentence denotes During this period, NF-κB increased from its minimum level at 6 h.
T6872 3890-4011 Sentence denotes PKC has been shown to be associated with the activation of AP-1, but not with NF-κB activation of the IL-2 promoter [45].
T6873 4012-4150 Sentence denotes Mutation of the NF-κB site did not affect IL-2 expression, whereas mutation of the AP-1 site or PKC depletion almost revoked IL-2 release.
T6874 4151-4330 Sentence denotes These observations indicate that the MAPK pathway and the transcription factor AP-1 play an important role in the induction of inflammatory responses in Jurkat T-cells [12,20,22].
T6875 4331-4420 Sentence denotes The obtained results signify that CXCL8 was primarily regulated through the MAPK pathway.
T6876 4421-4621 Sentence denotes The NF-κB activation inhibitor (NAI) showed specificity against NF-κB and resulted in a complete IL-6 inhibition following induction with PMA and significant IL-6 reduction after HK E. coli treatment.
T6877 4622-4733 Sentence denotes CXCL8 was highly up regulated by PMA and the addition of NAI resulted in a minor reduction in CXCL8 expression.
T6878 4734-4877 Sentence denotes Furthermore, CXCL8 expression was not affected by NAI following HK E. coli treatment, indicating a lack of correlation between CXCL8 and NF-κB.
T6879 4878-5035 Sentence denotes Further analysis of CXCL8 expression revealed a down-regulation by PKC- and JNK- inhibitors, suggesting an involvement of AP-1 via PKC and JNK, respectively.
T6880 5036-5126 Sentence denotes Analysis of gene expression further confirmed that il-6 and cxcl8 were upregulated by PMA.
T6881 5127-5329 Sentence denotes Expression of il-6 dropped below basal levels following inhibition of NF-κB and JNK whereas cxcl8 remained elevated above basal levels (16.5-fold and 7.1-fold respectively) following the same treatment.
T6882 5330-5472 Sentence denotes Furthermore, inhibition of PKC did not result in a significant decrease of il-6 or cxcl8, which is in accordance with protein data (figure 6).
T6888 6145-6270 Sentence denotes Down-regulation of Bcl10 from signals transduced via the TCR/CD28 and PKC resulted in a concomitant down-regulation of NF-κB.
T6889 6271-6393 Sentence denotes They suggested that Bcl10 is initially activated by TCR/PKC but that continued activation (>1 h) promotes its degradation.
T6890 6394-6542 Sentence denotes Narayan and colleagues [27] suggested that deletion in any of the three CBM complex proteins impairs antigen-receptor dependent activation of NF-κB.
T6891 6543-6700 Sentence denotes They showed that NF-κB activation via Akt requires CARMA1 and acts in cooperation with PKC following short-term exposure (30 min) of Jurkat T-cells with PMA.
T6892 6701-6745 Sentence denotes Akt phosphorylates and thus activates Bcl10.
T6893 6746-6939 Sentence denotes These studies indicate that PKC is crucial for NF-κB activation following short-term treatment through signals via membrane bound receptors such as the TCR and the co-stimulatory receptor CD28.
T6894 6940-7014 Sentence denotes Thus, the CBM complex proteins play a key role in this signalling process.
T6895 7015-7119 Sentence denotes PMA diffuses into the cytosol and directly activates PKC since it is an analogue to diacylglycerol [48].
T6896 7120-7286 Sentence denotes Several studies have demonstrated that inhibition of PKC blocks NF-κB and AP-1 activity, suggesting a direct regulation of these transcription factors by PKC [49,50].
T6897 7287-7474 Sentence denotes PKC is activated at an early stage following T-cell stimulation and is therefore an important regulator of downstream inflammatory signalling pathways leading to cytokine expression [50].
T6898 7475-7647 Sentence denotes We have shown that phosphorylated-PKC is up regulated in response to PMA and HK E. coli, indicating an association between PKC and the transcription factors AP-1 and NF-κB.
T6899 7648-7737 Sentence denotes Bcl10 levels were down-regulated following extended treatment of Jurkat T-cells with PMA.
T6900 7738-7900 Sentence denotes In the control groups, a loss of Bcl10 occurred after 6 h, followed by an increase after 24 h, which is in accordance with the observed NF-κB activity (figure 7).
T6901 7901-8048 Sentence denotes These results are supported by an earlier study [47], demonstrating that prolonged PKC activation by PMA leads to an inhibition of Bcl10 and NF-κB.
T6902 8049-8269 Sentence denotes It has been shown that NF-κB is an important transcription factor complex involved in almost every aspect of cell regulation including apoptosis, differentiation, proliferation and initiation of immune responses [51-53].
T6903 8270-8382 Sentence denotes NF-κB is constitutively active in many human malignancies, which makes it an attractive therapeutic target [54].
T6904 8383-8616 Sentence denotes Elevated CXCL8 levels during chronic inflammation result in an enhanced recruitment of immune cells to the site of infection, which may lead to the development of autoimmune diseases following secretion of pro-inflammatory cytokines.
T6905 8617-8826 Sentence denotes In HIV infected persons, serum CXCL8 levels are elevated and this could recruit more T-cells potentially leading to a more rapid progression of the disease since there will be more T-cells available to infect.
T6883 5473-5620 Sentence denotes These results suggest that NF-κB is involved in IL-6 regulation and release while it is not required for the expression of CXCL8 in Jurkat T cells.
T6884 5621-5779 Sentence denotes The transcription factor NF-κB is responsible for a rapid immune response which is followed by an increase in transcription of IκB thus inhibiting NF-κB [46].
T6885 5780-5886 Sentence denotes Activation of NF-κB in Jurkat T-cells is dependent on Bcl10 activation, which in turn is regulated by PKC.
T6886 5887-6026 Sentence denotes Recent studies have established the importance of a protein complex consisting of CARMA1, Bcl10 and MALT1 (CBM), in the induction of NF-κB.
T6887 6027-6144 Sentence denotes Investigating Bcl10, Scharschmidt and colleagues [47] demonstrated that it is a critical regulator of NF-κB activity.
T119 0-10 Sentence denotes Discussion
T120 11-233 Sentence denotes NF-κB and AP-1 are critical regulators of inflammatory responses, proliferation and differentiation of T-cells [28-30], however, the signal transduction and subsequent cytokine/chemokine expression is not fully understood.
T121 234-344 Sentence denotes The aim of the present study was to investigate IL-6 and CXCL8 regulation by NF-κB and AP-1 in Jurkat T-cells.
T122 345-457 Sentence denotes Our results demonstrated that PMA induced AP-1 activation, indicating a specific activation of the MAPK pathway.
T123 458-596 Sentence denotes Furthermore, we demonstrated that PMA dependent AP-1 activation in T-cells was delayed (>2 h) and increased following long-term treatment.
T124 597-711 Sentence denotes MAPK is one of the main signalling pathways in T-cells that regulate cell- and transcriptional activation [31,32].
T125 712-892 Sentence denotes Several studies [20,33,34] have indicated the importance of AP-1 in T-cell activation and the induction of inflammatory responses [35], including pro-inflammatory cytokine release.
T126 893-1033 Sentence denotes In contrast to AP-1, NF-κB activity rapidly increased (1 min) during PMA exposure followed by a down-regulation to the lowest levels at 6 h.
T127 1034-1244 Sentence denotes This is in line with Park and colleagues [36] who demonstrated a rapid increase in NF-κB activity following short-term stimulation with PMA, but prolonged challenge resulted in a persistent inhibition of NF-κB.
T128 1245-1364 Sentence denotes They showed that the inhibition of NF-κB was due to PKC-dependent degradation of IκB kinase β and γ in response to PMA.
T129 1365-1461 Sentence denotes Interestingly, the HK E. coli exposure induced NF-κB activation without affecting AP-1 activity.
T130 1462-1613 Sentence denotes Wang and colleagues [37] reported an elevated inflammatory response by obtaining expression of IL-6 following the exposure of T-cells to peptidoglycan.
T131 1614-1814 Sentence denotes Reduction in NF-κB by calcium ionophore following HK E. coli stimulation may be due to the Ca2+ binding protein calmodulin (CaM), which has been shown to negatively regulate c-Rel when activated [38].
T132 1815-1916 Sentence denotes The regulation of NF-κB and AP-1 observed in the present study was in agreement with earlier studies.
T133 1917-2087 Sentence denotes T-cells produce a broad range of pro- and anti-inflammatory cytokines, including IL-2, IL-6, CXCL8, TNF and IL-10, in response to infections or other stress factors [39].
T134 2088-2252 Sentence denotes The assessment of Jurkat T-cell inflammatory responses (Table 1) revealed an enhanced IL-2 expression upon exposure to PMA or HK E. coli due to PKC activation [40].
T135 2253-2405 Sentence denotes In addition to the transcription factor NF-κB, AP-1 binding sites have been identified in the IL-6 promoter region, indicating multiple regulation [22].
T136 2406-2537 Sentence denotes AP-1 and NF-κB have also been demonstrated to regulate CXCL8 expression during induction of inflammatory responses in T-cells [12].
T137 2538-2649 Sentence denotes Furthermore, IL-6 and CXCL8 gene-expression is associated with an early immune response in Jurkat T-cells [41].
T138 2650-2791 Sentence denotes In the present study, both PMA and HK E. coli resulted in comparable increases in IL-6 while PMA was more potent at activating CXCL8 release.
T139 2792-2849 Sentence denotes PMA and HK E. coli treatment also induced TNF expression.
T140 2850-2980 Sentence denotes TNF is one of the first cytokines induced by T-cells [42] and its expression is regulated by calcineurin, NFAT and ATF-2/Jun [20].
T141 2981-3105 Sentence denotes However, PMA-stimulated Jurkat T-cells showed no difference in IL-10 expression indicating an induced inflammatory response.
T142 3106-3183 Sentence denotes HK E. coli treatment resulted in a significant reduction of IL-10 expression.
T143 3184-3428 Sentence denotes The anti-inflammatory cytokine IL-10 is known to inhibit T-cell activation, proliferation and the expression of pro-inflammatory cytokines, such as IL-2, IL-5 and INF-γ [39,43] and regulate inflammatory responses by inducing T-cell anergy [44].
T144 3429-3621 Sentence denotes The time course analysis of cytokine expression showed a correlation between AP-1 and the chemokine CXCL8 where CXCL8 expression was significantly elevated already at 2-6 h after PMA exposure.
T145 3622-3759 Sentence denotes The CXCL8 expression did not correlate with the early NF-κB activation (1 min) or with the down-regulation of NF-κB at 2 h post exposure.
T146 3760-3822 Sentence denotes Both IL-6 and TNF expression were up regulated between 6-24 h.
T147 3823-3889 Sentence denotes During this period, NF-κB increased from its minimum level at 6 h.
T148 3890-4011 Sentence denotes PKC has been shown to be associated with the activation of AP-1, but not with NF-κB activation of the IL-2 promoter [45].
T149 4012-4150 Sentence denotes Mutation of the NF-κB site did not affect IL-2 expression, whereas mutation of the AP-1 site or PKC depletion almost revoked IL-2 release.
T150 4151-4330 Sentence denotes These observations indicate that the MAPK pathway and the transcription factor AP-1 play an important role in the induction of inflammatory responses in Jurkat T-cells [12,20,22].
T151 4331-4420 Sentence denotes The obtained results signify that CXCL8 was primarily regulated through the MAPK pathway.
T152 4421-4621 Sentence denotes The NF-κB activation inhibitor (NAI) showed specificity against NF-κB and resulted in a complete IL-6 inhibition following induction with PMA and significant IL-6 reduction after HK E. coli treatment.
T153 4622-4733 Sentence denotes CXCL8 was highly up regulated by PMA and the addition of NAI resulted in a minor reduction in CXCL8 expression.
T154 4734-4877 Sentence denotes Furthermore, CXCL8 expression was not affected by NAI following HK E. coli treatment, indicating a lack of correlation between CXCL8 and NF-κB.
T155 4878-5035 Sentence denotes Further analysis of CXCL8 expression revealed a down-regulation by PKC- and JNK- inhibitors, suggesting an involvement of AP-1 via PKC and JNK, respectively.
T156 5036-5126 Sentence denotes Analysis of gene expression further confirmed that il-6 and cxcl8 were upregulated by PMA.
T157 5127-5329 Sentence denotes Expression of il-6 dropped below basal levels following inhibition of NF-κB and JNK whereas cxcl8 remained elevated above basal levels (16.5-fold and 7.1-fold respectively) following the same treatment.
T158 5330-5472 Sentence denotes Furthermore, inhibition of PKC did not result in a significant decrease of il-6 or cxcl8, which is in accordance with protein data (figure 6).
T159 5473-5620 Sentence denotes These results suggest that NF-κB is involved in IL-6 regulation and release while it is not required for the expression of CXCL8 in Jurkat T cells.
T160 5621-5779 Sentence denotes The transcription factor NF-κB is responsible for a rapid immune response which is followed by an increase in transcription of IκB thus inhibiting NF-κB [46].
T161 5780-5886 Sentence denotes Activation of NF-κB in Jurkat T-cells is dependent on Bcl10 activation, which in turn is regulated by PKC.
T162 5887-6026 Sentence denotes Recent studies have established the importance of a protein complex consisting of CARMA1, Bcl10 and MALT1 (CBM), in the induction of NF-κB.
T163 6027-6144 Sentence denotes Investigating Bcl10, Scharschmidt and colleagues [47] demonstrated that it is a critical regulator of NF-κB activity.
T164 6145-6270 Sentence denotes Down-regulation of Bcl10 from signals transduced via the TCR/CD28 and PKC resulted in a concomitant down-regulation of NF-κB.
T165 6271-6393 Sentence denotes They suggested that Bcl10 is initially activated by TCR/PKC but that continued activation (>1 h) promotes its degradation.
T166 6394-6542 Sentence denotes Narayan and colleagues [27] suggested that deletion in any of the three CBM complex proteins impairs antigen-receptor dependent activation of NF-κB.
T167 6543-6700 Sentence denotes They showed that NF-κB activation via Akt requires CARMA1 and acts in cooperation with PKC following short-term exposure (30 min) of Jurkat T-cells with PMA.
T168 6701-6745 Sentence denotes Akt phosphorylates and thus activates Bcl10.
T169 6746-6939 Sentence denotes These studies indicate that PKC is crucial for NF-κB activation following short-term treatment through signals via membrane bound receptors such as the TCR and the co-stimulatory receptor CD28.
T170 6940-7014 Sentence denotes Thus, the CBM complex proteins play a key role in this signalling process.
T171 7015-7119 Sentence denotes PMA diffuses into the cytosol and directly activates PKC since it is an analogue to diacylglycerol [48].
T172 7120-7286 Sentence denotes Several studies have demonstrated that inhibition of PKC blocks NF-κB and AP-1 activity, suggesting a direct regulation of these transcription factors by PKC [49,50].
T173 7287-7474 Sentence denotes PKC is activated at an early stage following T-cell stimulation and is therefore an important regulator of downstream inflammatory signalling pathways leading to cytokine expression [50].
T174 7475-7647 Sentence denotes We have shown that phosphorylated-PKC is up regulated in response to PMA and HK E. coli, indicating an association between PKC and the transcription factors AP-1 and NF-κB.
T175 7648-7737 Sentence denotes Bcl10 levels were down-regulated following extended treatment of Jurkat T-cells with PMA.
T176 7738-7900 Sentence denotes In the control groups, a loss of Bcl10 occurred after 6 h, followed by an increase after 24 h, which is in accordance with the observed NF-κB activity (figure 7).
T177 7901-8048 Sentence denotes These results are supported by an earlier study [47], demonstrating that prolonged PKC activation by PMA leads to an inhibition of Bcl10 and NF-κB.
T178 8049-8269 Sentence denotes It has been shown that NF-κB is an important transcription factor complex involved in almost every aspect of cell regulation including apoptosis, differentiation, proliferation and initiation of immune responses [51-53].
T179 8270-8382 Sentence denotes NF-κB is constitutively active in many human malignancies, which makes it an attractive therapeutic target [54].
T180 8383-8616 Sentence denotes Elevated CXCL8 levels during chronic inflammation result in an enhanced recruitment of immune cells to the site of infection, which may lead to the development of autoimmune diseases following secretion of pro-inflammatory cytokines.
T181 8617-8826 Sentence denotes In HIV infected persons, serum CXCL8 levels are elevated and this could recruit more T-cells potentially leading to a more rapid progression of the disease since there will be more T-cells available to infect.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T10965 282-286 Protein denotes IL-6
T10966 291-296 Protein denotes CXCL8
T10967 297-307 Regulation denotes regulation true
T10968 297-307 Regulation denotes regulation true
T10969 1301-1310 Regulation denotes dependent
T10970 1301-1310 Regulation denotes dependent
T10971 1311-1322 Protein_catabolism denotes degradation
T10972 1311-1322 Protein_catabolism denotes degradation
T10973 1326-1338 Protein denotes IκB kinase β
T10974 1343-1344 Protein denotes γ
T10975 1345-1359 Positive_regulation denotes in response to
T10976 1345-1359 Positive_regulation denotes in response to
T10977 1543-1553 Gene_expression denotes expression
T10978 1557-1561 Protein denotes IL-6
T10979 1562-1571 Positive_regulation denotes following
T10980 1768-1787 Negative_regulation denotes negatively regulate
T10981 1788-1793 Protein denotes c-Rel
T10982 1998-2002 Protein denotes IL-2
T10983 2004-2008 Protein denotes IL-6
T10984 2010-2015 Protein denotes CXCL8
T10985 2025-2030 Protein denotes IL-10
T10986 2165-2173 Positive_regulation denotes enhanced
T10987 2174-2178 Protein denotes IL-2
T10988 2179-2189 Gene_expression denotes expression
T10989 2225-2228 Positive_regulation denotes due
T10990 2347-2351 Protein denotes IL-6
T10991 2389-2399 Regulation denotes regulation
T10992 2461-2466 Protein denotes CXCL8
T10993 2467-2477 Gene_expression denotes expression
T10994 2551-2555 Protein denotes IL-6
T10995 2560-2565 Protein denotes CXCL8
T10996 2571-2581 Gene_expression denotes expression
T10997 2571-2581 Gene_expression denotes expression
T10998 2719-2728 Positive_regulation denotes increases
T10999 2732-2736 Protein denotes IL-6
T11000 2766-2776 Positive_regulation denotes activating
T11001 2777-2782 Protein denotes CXCL8
T11002 2783-2790 Localization denotes release
T11003 2965-2970 Protein denotes ATF-2
T11004 3020-3040 Regulation denotes showed no difference true
T11005 3044-3049 Protein denotes IL-10
T11006 3050-3060 Gene_expression denotes expression
T11007 3153-3162 Negative_regulation denotes reduction
T11008 3166-3171 Protein denotes IL-10
T11009 3172-3182 Gene_expression denotes expression
T11010 3215-3220 Protein denotes IL-10
T11011 3332-3336 Protein denotes IL-2
T11012 3338-3342 Protein denotes IL-5
T11013 3347-3352 Protein denotes INF-γ
T11014 3529-3534 Protein denotes CXCL8
T11015 3765-3769 Protein denotes IL-6
T11016 3778-3788 Gene_expression denotes expression
T11017 3794-3806 Positive_regulation denotes up regulated
T11018 3974-3984 Positive_regulation denotes activation
T11019 3992-3996 Protein denotes IL-2
T11020 3997-4005 Entity denotes promoter
T11021 4012-4020 Regulation denotes Mutation
T11022 4028-4038 Entity denotes NF-κB site
T11023 4047-4053 Regulation denotes affect true
T11024 4054-4058 Protein denotes IL-2
T11025 4059-4069 Gene_expression denotes expression
T11026 4079-4087 Regulation denotes mutation
T11027 4095-4104 Entity denotes AP-1 site
T11028 4129-4136 Negative_regulation denotes revoked
T11029 4137-4141 Protein denotes IL-2
T11030 4142-4149 Localization denotes release
T11031 4495-4503 Positive_regulation denotes resulted
T11032 4495-4503 Positive_regulation denotes resulted
T11033 4518-4522 Protein denotes IL-6
T11034 4523-4533 Negative_regulation denotes inhibition
T11035 4544-4553 Positive_regulation denotes induction
T11036 4579-4583 Protein denotes IL-6
T11037 4584-4593 Negative_regulation denotes reduction
T11038 4703-4712 Negative_regulation denotes reduction
T11039 4716-4721 Protein denotes CXCL8
T11040 4722-4732 Gene_expression denotes expression
T11041 4747-4752 Protein denotes CXCL8
T11042 4753-4763 Gene_expression denotes expression
T11043 4772-4780 Regulation denotes affected true
T11044 4788-4797 Positive_regulation denotes following
T11045 4861-4866 Protein denotes CXCL8
T11046 4898-4903 Protein denotes CXCL8
T11047 4904-4914 Gene_expression denotes expression
T11048 4926-4941 Negative_regulation denotes down-regulation
T11049 4985-4996 Regulation denotes involvement
T11050 5005-5008 Positive_regulation denotes via true
T11051 5087-5091 Protein denotes il-6
T11052 5096-5101 Protein denotes cxcl8
T11053 5107-5118 Positive_regulation denotes upregulated
T11054 5107-5118 Positive_regulation denotes upregulated
T11055 5127-5137 Gene_expression denotes Expression
T11056 5141-5145 Protein denotes il-6
T11057 5146-5153 Negative_regulation denotes dropped
T11058 5219-5224 Protein denotes cxcl8
T11059 5225-5242 Negative_regulation denotes remained elevated true
T11060 5393-5401 Negative_regulation denotes decrease true
T11061 5393-5401 Negative_regulation denotes decrease true
T11062 5405-5409 Protein denotes il-6
T11063 5413-5418 Protein denotes cxcl8
T11064 5509-5517 Regulation denotes involved true
T11065 5509-5517 Regulation denotes involved true
T11066 5521-5525 Protein denotes IL-6
T11067 5526-5536 Regulation denotes regulation
T11068 5541-5548 Localization denotes release
T11069 5565-5573 Regulation denotes required true true
T11070 5582-5592 Gene_expression denotes expression
T11071 5596-5601 Protein denotes CXCL8
T11072 5834-5839 Protein denotes Bcl10
T11073 5840-5850 Positive_regulation denotes activation
T11074 5869-5878 Regulation denotes regulated
T11075 5969-5975 Protein denotes CARMA1
T11076 5977-5982 Protein denotes Bcl10
T11077 5987-5992 Protein denotes MALT1
T11078 6041-6046 Protein denotes Bcl10
T11079 6145-6160 Negative_regulation denotes Down-regulation
T11080 6164-6169 Protein denotes Bcl10
T11081 6206-6210 Protein denotes CD28
T11082 6291-6296 Protein denotes Bcl10
T11083 6310-6319 Positive_regulation denotes activated true
T11084 6368-6376 Positive_regulation denotes promotes
T11085 6381-6392 Protein_catabolism denotes degradation
T11086 6437-6445 Negative_regulation denotes deletion
T11087 6437-6445 Negative_regulation denotes deletion
T11088 6437-6445 Negative_regulation denotes deletion
T11089 6594-6600 Protein denotes CARMA1
T11090 6705-6719 Phosphorylation denotes phosphorylates
T11091 6729-6738 Positive_regulation denotes activates
T11092 6739-6744 Protein denotes Bcl10
T11093 6934-6938 Protein denotes CD28
T11094 7648-7653 Protein denotes Bcl10
T11095 7666-7680 Negative_regulation denotes down-regulated
T11096 7763-7767 Negative_regulation denotes loss
T11097 7771-7776 Protein denotes Bcl10
T11098 7812-7820 Positive_regulation denotes increase
T11099 8006-8011 Positive_regulation denotes leads
T11100 8018-8028 Negative_regulation denotes inhibition
T11101 8032-8037 Protein denotes Bcl10
T11102 8383-8391 Positive_regulation denotes Elevated
T11103 8392-8397 Protein denotes CXCL8
T11104 8648-8653 Protein denotes CXCL8
T11105 8665-8673 Positive_regulation denotes elevated
R8813 T11001 T11002 themeOf CXCL8,release
R8814 T10965 T10968 themeOf IL-6,regulation
R8815 T10966 T10967 themeOf CXCL8,regulation
R8816 T11002 T11000 themeOf release,activating
R8817 T11005 T11006 themeOf IL-10,expression
R8818 T10969 T10976 themeOf dependent,in response to
R8819 T10970 T10975 themeOf dependent,in response to
R8820 T10971 T10970 themeOf degradation,dependent
R8821 T11006 T11004 themeOf expression,showed no difference
R8822 T11008 T11009 themeOf IL-10,expression
R8824 T10973 T10972 themeOf IκB kinase β,degradation
R8825 T10974 T10971 themeOf γ,degradation
R8826 T11009 T11007 themeOf expression,reduction
R8827 T10977 T10979 themeOf expression,following
R8828 T11015 T11016 themeOf IL-6,expression
R8829 T10978 T10977 themeOf IL-6,expression
R8830 T10981 T10980 themeOf c-Rel,negatively regulate
R8831 T11016 T11017 themeOf expression,up regulated
R8832 T10986 T10989 themeOf enhanced,due
R8833 T11020 T11018 themeOf promoter,activation
R8834 T10987 T10988 themeOf IL-2,expression
R8835 T10988 T10986 themeOf expression,enhanced
R8836 T10990 T10991 themeOf IL-6,regulation
R8837 T10992 T10993 themeOf CXCL8,expression
R8838 T11020 T11019 partOf promoter,IL-2
R8839 T10994 T10997 themeOf IL-6,expression
R8840 T11021 T11023 causeOf Mutation,affect
R8841 T10995 T10996 themeOf CXCL8,expression
R8842 T11022 T11021 themeOf NF-κB site,Mutation
R8843 T10999 T10998 themeOf IL-6,increases
R8844 T11022 T11024 partOf NF-κB site,IL-2
R8845 T11024 T11025 themeOf IL-2,expression
R8846 T11025 T11023 themeOf expression,affect
R8847 T11026 T11028 causeOf mutation,revoked
R8851 T11027 T11026 themeOf AP-1 site,mutation
R8853 T11027 T11029 partOf AP-1 site,IL-2
R8854 T11029 T11030 themeOf IL-2,release
R8855 T11030 T11028 themeOf release,revoked
R8856 T11033 T11034 themeOf IL-6,inhibition
R8857 T11033 T11035 themeOf IL-6,induction
R8858 T11034 T11031 themeOf inhibition,resulted
R8859 T11036 T11037 themeOf IL-6,reduction
R8860 T11037 T11032 themeOf reduction,resulted
R8865 T11039 T11040 themeOf CXCL8,expression
R8870 T11040 T11038 themeOf expression,reduction
R8872 T11041 T11042 themeOf CXCL8,expression
R8875 T11042 T11043 themeOf expression,affected
R8878 T11042 T11044 themeOf expression,following
R8879 T11046 T11047 themeOf CXCL8,expression
R8884 T11047 T11048 themeOf expression,down-regulation
R8886 T11047 T11049 themeOf expression,involvement
R8887 T11049 T11050 themeOf involvement,via
R8889 T11051 T11053 themeOf il-6,upregulated
R8895 T11052 T11054 themeOf cxcl8,upregulated
R8897 T11055 T11057 themeOf Expression,dropped
R8903 T11056 T11055 themeOf il-6,Expression
R8904 T11058 T11059 themeOf cxcl8,remained elevated
R8907 T11062 T11061 themeOf il-6,decrease
R8912 T11063 T11060 themeOf cxcl8,decrease
R8915 T11066 T11067 themeOf IL-6,regulation
R8916 T11066 T11068 themeOf IL-6,release
R8917 T11067 T11065 themeOf regulation,involved
R8919 T11068 T11064 themeOf release,involved
R8922 T11070 T11069 themeOf expression,required
R8923 T11071 T11070 themeOf CXCL8,expression
R8924 T11072 T11073 themeOf Bcl10,activation
R8925 T11073 T11074 themeOf activation,regulated
R8926 T11075 T11087 themeOf CARMA1,deletion
R8932 T11076 T11086 themeOf Bcl10,deletion
R8933 T11077 T11088 themeOf MALT1,deletion
R8936 T11080 T11079 themeOf Bcl10,Down-regulation
R8939 T11081 T11079 causeOf CD28,Down-regulation
R8941 T11082 T11083 themeOf Bcl10,activated
R8944 T11082 T11085 themeOf Bcl10,degradation
R8971 T11083 T11084 causeOf activated,promotes
R8972 T11085 T11084 themeOf degradation,promotes
R8973 T11092 T11090 themeOf Bcl10,phosphorylates
R8974 T11092 T11091 themeOf Bcl10,activates
R8976 T11094 T11095 themeOf Bcl10,down-regulated
R8823 T10972 T10969 themeOf degradation,dependent
R8848 T11100 T11099 themeOf inhibition,leads
R8849 T11101 T11100 themeOf Bcl10,inhibition
R8850 T11103 T11102 themeOf CXCL8,Elevated
R8852 T11104 T11105 themeOf CXCL8,elevated
R8982 T11097 T11096 themeOf Bcl10,loss
R8988 T11097 T11098 themeOf Bcl10,increase

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T11106 11-16 Protein denotes NF-κB
T11107 21-25 Protein denotes AP-1
T11108 282-286 Protein denotes IL-6
T11109 291-296 Protein denotes CXCL8
T11110 311-316 Protein denotes NF-κB
T11111 321-325 Protein denotes AP-1
T11112 297-307 Regulation denotes regulation
T11113 297-307 Regulation denotes regulation
T11114 297-307 Regulation denotes regulation
T11115 297-307 Regulation denotes regulation
T11116 387-391 Protein denotes AP-1
T11117 444-448 Protein denotes MAPK
T11118 392-402 Positive_regulation denotes activation
T11119 426-436 Positive_regulation denotes activation
T11120 379-386 Positive_regulation denotes induced
T11121 506-510 Protein denotes AP-1
T11122 511-521 Positive_regulation denotes activation
T11123 556-565 Positive_regulation denotes increased
T11124 597-601 Protein denotes MAPK
T11125 772-776 Protein denotes AP-1
T11126 908-912 Protein denotes AP-1
T11127 914-919 Protein denotes NF-κB
T11128 937-946 Positive_regulation denotes increased
T11129 937-946 Positive_regulation denotes increased
T11130 1117-1122 Protein denotes NF-κB
T11131 1238-1243 Protein denotes NF-κB
T11132 1105-1113 Positive_regulation denotes increase
T11133 1224-1234 Negative_regulation denotes inhibition
T11134 1280-1285 Protein denotes NF-κB
T11135 1297-1300 Protein denotes PKC
T11136 1326-1344 Protein denotes IκB kinase β and γ
T11137 1266-1276 Negative_regulation denotes inhibition
T11138 1311-1322 Protein_catabolism denotes degradation
T11139 1348-1356 Positive_regulation denotes response
T11140 1290-1293 Positive_regulation denotes due
T11141 1301-1310 Positive_regulation denotes dependent
T11142 1384-1403 Protein denotes HK E. coli exposure
T11143 1412-1417 Protein denotes NF-κB
T11144 1447-1451 Protein denotes AP-1
T11145 1418-1428 Positive_regulation denotes activation
T11146 1437-1446 Regulation denotes affecting
T11147 1404-1411 Positive_regulation denotes induced
T11148 1557-1561 Protein denotes IL-6
T11149 1543-1553 Gene_expression denotes expression
T11150 1627-1632 Protein denotes NF-κB
T11151 1664-1674 Protein denotes HK E. coli
T11152 1705-1736 Protein denotes Ca2+ binding protein calmodulin
T11153 1738-1741 Protein denotes CaM
T11154 1788-1793 Protein denotes c-Rel
T11155 1614-1623 Negative_regulation denotes Reduction
T11156 1779-1787 Negative_regulation denotes regulate
T11157 1833-1838 Protein denotes NF-κB
T11158 1843-1847 Protein denotes AP-1
T11159 1819-1829 Regulation denotes regulation
T11160 1819-1829 Regulation denotes regulation
T11161 1998-2002 Protein denotes IL-2
T11162 2004-2008 Protein denotes IL-6
T11163 2010-2015 Protein denotes CXCL8
T11164 2017-2020 Protein denotes TNF
T11165 2025-2030 Protein denotes IL-10
T11166 1925-1932 Gene_expression denotes produce
T11167 1925-1932 Gene_expression denotes produce
T11168 1925-1932 Gene_expression denotes produce
T11169 1925-1932 Gene_expression denotes produce
T11170 1925-1932 Gene_expression denotes produce
T11171 2174-2178 Protein denotes IL-2
T11172 2214-2228 Protein denotes HK E. coli due
T11173 2232-2235 Protein denotes PKC
T11174 2179-2189 Gene_expression denotes expression
T11175 2236-2246 Positive_regulation denotes activation
T11176 2165-2173 Positive_regulation denotes enhanced
T11177 2272-2298 Protein denotes transcription factor NF-κB
T11178 2300-2318 Protein denotes AP-1 binding sites
T11179 2347-2367 Protein denotes IL-6 promoter region
T11180 2406-2410 Protein denotes AP-1
T11181 2415-2420 Protein denotes NF-κB
T11182 2461-2466 Protein denotes CXCL8
T11183 2467-2477 Gene_expression denotes expression
T11184 2452-2460 Regulation denotes regulate
T11185 2452-2460 Regulation denotes regulate
T11186 2551-2555 Protein denotes IL-6
T11187 2560-2565 Protein denotes CXCL8
T11188 2566-2581 Gene_expression denotes gene-expression
T11189 2566-2581 Gene_expression denotes gene-expression
T11190 2732-2736 Protein denotes IL-6
T11191 2777-2790 Protein denotes CXCL8 release
T11192 2719-2728 Positive_regulation denotes increases
T11193 2766-2776 Positive_regulation denotes activating
T11194 2834-2837 Protein denotes TNF
T11195 2838-2848 Gene_expression denotes expression
T11196 2826-2833 Positive_regulation denotes induced
T11197 2850-2853 Protein denotes TNF
T11198 2943-2954 Protein denotes calcineurin
T11199 2956-2960 Protein denotes NFAT
T11200 2965-2970 Protein denotes ATF-2
T11201 2971-2974 Protein denotes Jun
T11202 2916-2926 Gene_expression denotes expression
T11203 2916-2926 Gene_expression denotes expression
T11204 2916-2926 Gene_expression denotes expression
T11205 2930-2939 Regulation denotes regulated
T11206 2930-2939 Regulation denotes regulated
T11207 2930-2939 Regulation denotes regulated
T11208 2930-2939 Regulation denotes regulated
T11209 2930-2939 Regulation denotes regulated
T11210 2930-2939 Regulation denotes regulated
T11211 2930-2939 Regulation denotes regulated
T11212 2930-2939 Regulation denotes regulated
T11213 2930-2939 Regulation denotes regulated
T11214 2930-2939 Regulation denotes regulated
T11215 2930-2939 Regulation denotes regulated
T11216 2930-2939 Regulation denotes regulated
T11217 3166-3171 Protein denotes IL-10
T11218 3172-3182 Gene_expression denotes expression
T11219 3153-3162 Negative_regulation denotes reduction
T11220 3206-3220 Protein denotes cytokine IL-10
T11221 3332-3336 Protein denotes IL-2
T11222 3338-3342 Protein denotes IL-5
T11223 3347-3352 Protein denotes INF-γ
T11224 3282-3292 Gene_expression denotes expression
T11225 3282-3292 Gene_expression denotes expression
T11226 3282-3292 Gene_expression denotes expression
T11227 3233-3240 Negative_regulation denotes inhibit
T11228 3233-3240 Negative_regulation denotes inhibit
T11229 3233-3240 Negative_regulation denotes inhibit
T11230 3506-3510 Protein denotes AP-1
T11231 3529-3534 Protein denotes CXCL8
T11232 3541-3546 Protein denotes CXCL8
T11233 3547-3557 Gene_expression denotes expression
T11234 3576-3584 Positive_regulation denotes elevated
T11235 3626-3631 Protein denotes CXCL8
T11236 3732-3737 Protein denotes NF-κB
T11237 3632-3642 Gene_expression denotes expression
T11238 3713-3728 Negative_regulation denotes down-regulation
T11239 3765-3769 Protein denotes IL-6
T11240 3774-3777 Protein denotes TNF
T11241 3778-3788 Gene_expression denotes expression
T11242 3778-3788 Gene_expression denotes expression
T11243 3797-3806 Regulation denotes regulated
T11244 3797-3806 Regulation denotes regulated
T11245 3797-3806 Regulation denotes regulated
T11246 3843-3848 Protein denotes NF-κB
T11247 3890-3893 Protein denotes PKC
T11248 3949-3953 Protein denotes AP-1
T11249 3968-3973 Protein denotes NF-κB
T11250 3992-4010 Protein denotes IL-2 promoter [45]
T11251 3915-3925 Binding denotes associated
T11252 3935-3945 Positive_regulation denotes activation
T11253 3974-3984 Positive_regulation denotes activation
T11254 3974-3984 Positive_regulation denotes activation
T11255 4028-4038 Protein denotes NF-κB site
T11256 4054-4058 Protein denotes IL-2
T11257 4095-4104 Protein denotes AP-1 site
T11258 4108-4111 Protein denotes PKC
T11259 4137-4149 Protein denotes IL-2 release
T11260 4012-4020 Localization denotes Mutation
T11261 4059-4069 Gene_expression denotes expression
T11262 4079-4087 Positive_regulation denotes mutation
T11263 4112-4121 Negative_regulation denotes depletion
T11264 4129-4136 Negative_regulation denotes revoked
T11265 4047-4053 Regulation denotes affect
T11266 4188-4192 Protein denotes MAPK
T11267 4209-4234 Protein denotes transcription factor AP-1
T11268 4365-4370 Protein denotes CXCL8
T11269 4407-4411 Protein denotes MAPK
T11270 4385-4394 Regulation denotes regulated
T11271 4425-4430 Protein denotes NF-κB
T11272 4485-4490 Protein denotes NF-κB
T11273 4518-4522 Protein denotes IL-6
T11274 4579-4583 Protein denotes IL-6
T11275 4442-4451 Negative_regulation denotes inhibitor
T11276 4523-4533 Negative_regulation denotes inhibition
T11277 4622-4627 Protein denotes CXCL8
T11278 4716-4721 Protein denotes CXCL8
T11279 4642-4651 Regulation denotes regulated
T11280 4722-4732 Gene_expression denotes expression
T11281 4703-4712 Negative_regulation denotes reduction
T11282 4747-4752 Protein denotes CXCL8
T11283 4861-4866 Protein denotes CXCL8
T11284 4871-4876 Protein denotes NF-κB
T11285 4753-4763 Gene_expression denotes expression
T11286 4772-4780 Regulation denotes affected
T11287 4898-4903 Protein denotes CXCL8
T11288 4945-4948 Protein denotes PKC
T11289 4954-4957 Protein denotes JNK
T11290 5000-5004 Protein denotes AP-1
T11291 5009-5012 Protein denotes PKC
T11292 5017-5020 Protein denotes JNK
T11293 4904-4914 Gene_expression denotes expression
T11294 4959-4969 Negative_regulation denotes inhibitors
T11295 4959-4969 Negative_regulation denotes inhibitors
T11296 4985-4996 Positive_regulation denotes involvement
T11297 5197-5202 Protein denotes NF-κB
T11298 5207-5210 Protein denotes JNK
T11299 5183-5193 Negative_regulation denotes inhibition
T11300 5183-5193 Negative_regulation denotes inhibition
T11301 5357-5360 Protein denotes PKC
T11302 5343-5353 Negative_regulation denotes inhibition
T11303 5500-5505 Protein denotes NF-κB
T11304 5521-5525 Protein denotes IL-6
T11305 5596-5601 Protein denotes CXCL8
T11306 5582-5592 Gene_expression denotes expression
T11307 5565-5573 Positive_regulation denotes required
T11308 5625-5651 Protein denotes transcription factor NF-κB
T11309 5748-5751 Protein denotes IκB
T11310 5768-5773 Protein denotes NF-κB
T11311 5731-5744 Transcription denotes transcription
T11312 5757-5767 Negative_regulation denotes inhibiting
T11313 5719-5727 Positive_regulation denotes increase
T11314 5794-5799 Protein denotes NF-κB
T11315 5834-5839 Protein denotes Bcl10
T11316 5882-5885 Protein denotes PKC
T11317 5780-5790 Positive_regulation denotes Activation
T11318 5840-5850 Positive_regulation denotes activation
T11319 5869-5878 Regulation denotes regulated
T11320 5969-5975 Protein denotes CARMA1
T11321 5977-5982 Protein denotes Bcl10
T11322 5987-5992 Protein denotes MALT1
T11323 6020-6025 Protein denotes NF-κB
T11324 6007-6016 Positive_regulation denotes induction
T11325 5923-5933 Regulation denotes importance
T11326 6129-6134 Protein denotes NF-κB
T11327 6164-6169 Protein denotes Bcl10
T11328 6202-6205 Protein denotes TCR
T11329 6206-6210 Protein denotes CD28
T11330 6215-6218 Protein denotes PKC
T11331 6264-6269 Protein denotes NF-κB
T11332 6145-6160 Negative_regulation denotes Down-regulation
T11333 6245-6260 Negative_regulation denotes down-regulation
T11334 6291-6296 Protein denotes Bcl10
T11335 6323-6326 Protein denotes TCR
T11336 6327-6330 Protein denotes PKC
T11337 6310-6319 Positive_regulation denotes activated
T11338 6310-6319 Positive_regulation denotes activated
T11339 6466-6511 Protein denotes CBM complex proteins impairs antigen-receptor
T11340 6536-6541 Protein denotes NF-κB
T11341 6522-6532 Positive_regulation denotes activation
T11342 6560-6565 Protein denotes NF-κB
T11343 6581-6584 Protein denotes Akt
T11344 6594-6600 Protein denotes CARMA1
T11345 6630-6633 Protein denotes PKC
T11346 6566-6576 Positive_regulation denotes activation
T11347 6566-6576 Positive_regulation denotes activation
T11348 6701-6704 Protein denotes Akt
T11349 6739-6744 Protein denotes Bcl10
T11350 6705-6719 Phosphorylation denotes phosphorylates
T11351 6729-6738 Positive_regulation denotes activates
T11352 6774-6777 Protein denotes PKC
T11353 6793-6798 Protein denotes NF-κB
T11354 6898-6901 Protein denotes TCR
T11355 6934-6938 Protein denotes CD28
T11356 6799-6809 Positive_regulation denotes activation
T11357 6781-6788 Positive_regulation denotes crucial
T11358 6950-6970 Protein denotes CBM complex proteins
T11359 7068-7071 Protein denotes PKC
T11360 7058-7067 Positive_regulation denotes activates
T11361 7173-7189 Protein denotes PKC blocks NF-κB
T11362 7194-7198 Protein denotes AP-1
T11363 7274-7277 Protein denotes PKC
T11364 7229-7239 Regulation denotes regulation
T11365 7287-7290 Protein denotes PKC
T11366 7294-7303 Positive_regulation denotes activated
T11367 7509-7512 Protein denotes PKC
T11368 7598-7601 Protein denotes PKC
T11369 7632-7636 Protein denotes AP-1
T11370 7641-7646 Protein denotes NF-κB
T11371 7494-7508 Phosphorylation denotes phosphorylated
T11372 7519-7528 Regulation denotes regulated
T11373 7519-7528 Regulation denotes regulated
T11374 7648-7653 Protein denotes Bcl10
T11375 7666-7680 Negative_regulation denotes down-regulated
T11376 7874-7879 Protein denotes NF-κB
T11377 7984-7987 Protein denotes PKC
T11378 8032-8037 Protein denotes Bcl10
T11379 8042-8047 Protein denotes NF-κB
T11380 7988-7998 Positive_regulation denotes activation
T11381 8018-8028 Negative_regulation denotes inhibition
T11382 8018-8028 Negative_regulation denotes inhibition
T11383 8072-8077 Protein denotes NF-κB
T11385 8392-8397 Protein denotes CXCL8
T11386 8383-8391 Positive_regulation denotes Elevated
T11387 8648-8653 Protein denotes CXCL8
T11388 8665-8673 Positive_regulation denotes elevated
T11384 8270-8275 Protein denotes NF-κB
R8861 T11108 T11112 themeOf IL-6,regulation
R8862 T11108 T11114 themeOf IL-6,regulation
R8863 T11109 T11113 themeOf CXCL8,regulation
R8864 T11109 T11115 themeOf CXCL8,regulation
R8866 T11110 T11112 causeOf NF-κB,regulation
R8867 T11110 T11113 causeOf NF-κB,regulation
R8868 T11111 T11114 causeOf AP-1,regulation
R8869 T11111 T11115 causeOf AP-1,regulation
R8871 T11116 T11118 themeOf AP-1,activation
R8873 T11117 T11119 themeOf MAPK,activation
R8874 T11118 T11120 themeOf activation,induced
R8876 T11121 T11122 themeOf AP-1,activation
R8877 T11122 T11123 themeOf activation,increased
R8880 T11126 T11128 themeOf AP-1,increased
R8881 T11127 T11129 themeOf NF-κB,increased
R8882 T11130 T11132 themeOf NF-κB,increase
R8883 T11131 T11133 themeOf NF-κB,inhibition
R8885 T11134 T11137 themeOf NF-κB,inhibition
R8888 T11135 T11141 causeOf PKC,dependent
R8890 T11136 T11138 themeOf IκB kinase β and γ,degradation
R8891 T11137 T11140 causeOf inhibition,due
R8892 T11138 T11139 themeOf degradation,response
R8893 T11138 T11140 themeOf degradation,due
R8894 T11138 T11141 themeOf degradation,dependent
R8896 T11142 T11147 causeOf HK E. coli exposure,induced
R8898 T11143 T11145 themeOf NF-κB,activation
R8899 T11144 T11146 themeOf AP-1,affecting
R8900 T11145 T11147 themeOf activation,induced
R8901 T11148 T11149 themeOf IL-6,expression
R8902 T11150 T11155 themeOf NF-κB,Reduction
R8905 T11154 T11156 themeOf c-Rel,regulate
R8906 T11157 T11159 themeOf NF-κB,regulation
R8908 T11158 T11160 themeOf AP-1,regulation
R8909 T11161 T11166 themeOf IL-2,produce
R8910 T11162 T11167 themeOf IL-6,produce
R8911 T11163 T11168 themeOf CXCL8,produce
R8913 T11164 T11169 themeOf TNF,produce
R8914 T11165 T11170 themeOf IL-10,produce
R8918 T11171 T11174 themeOf IL-2,expression
R8920 T11173 T11175 themeOf PKC,activation
R8921 T11174 T11176 themeOf expression,enhanced
R8927 T11180 T11184 causeOf AP-1,regulate
R8928 T11181 T11185 causeOf NF-κB,regulate
R8929 T11182 T11183 themeOf CXCL8,expression
R8930 T11183 T11184 themeOf expression,regulate
R8931 T11183 T11185 themeOf expression,regulate
R8934 T11186 T11188 themeOf IL-6,gene-expression
R8935 T11187 T11189 themeOf CXCL8,gene-expression
R8937 T11190 T11192 themeOf IL-6,increases
R8938 T11191 T11193 themeOf CXCL8 release,activating
R8940 T11194 T11195 themeOf TNF,expression
R8942 T11195 T11196 themeOf expression,induced
R8943 T11197 T11202 themeOf TNF,expression
R8945 T11198 T11205 causeOf calcineurin,regulated
R8946 T11198 T11206 causeOf calcineurin,regulated
R8947 T11198 T11207 causeOf calcineurin,regulated
R8948 T11199 T11208 causeOf NFAT,regulated
R8949 T11199 T11209 causeOf NFAT,regulated
R8950 T11199 T11210 causeOf NFAT,regulated
R8951 T11200 T11203 themeOf ATF-2,expression
R8952 T11200 T11211 causeOf ATF-2,regulated
R8953 T11200 T11212 causeOf ATF-2,regulated
R8954 T11200 T11213 causeOf ATF-2,regulated
R8955 T11201 T11204 themeOf Jun,expression
R8956 T11201 T11214 causeOf Jun,regulated
R8957 T11201 T11215 causeOf Jun,regulated
R8958 T11201 T11216 causeOf Jun,regulated
R8959 T11202 T11205 themeOf expression,regulated
R8960 T11202 T11208 themeOf expression,regulated
R8961 T11202 T11211 themeOf expression,regulated
R8962 T11202 T11214 themeOf expression,regulated
R8963 T11203 T11206 themeOf expression,regulated
R8964 T11203 T11209 themeOf expression,regulated
R8965 T11203 T11212 themeOf expression,regulated
R8966 T11203 T11215 themeOf expression,regulated
R8967 T11204 T11207 themeOf expression,regulated
R8968 T11204 T11210 themeOf expression,regulated
R8969 T11204 T11213 themeOf expression,regulated
R8970 T11204 T11216 themeOf expression,regulated
R8975 T11217 T11218 themeOf IL-10,expression
R8977 T11218 T11219 themeOf expression,reduction
R8978 T11220 T11227 causeOf cytokine IL-10,inhibit
R8979 T11220 T11228 causeOf cytokine IL-10,inhibit
R8980 T11220 T11229 causeOf cytokine IL-10,inhibit
R8981 T11221 T11224 themeOf IL-2,expression
R8983 T11222 T11225 themeOf IL-5,expression
R8984 T11223 T11226 themeOf INF-γ,expression
R8985 T11224 T11227 themeOf expression,inhibit
R8986 T11225 T11228 themeOf expression,inhibit
R8987 T11226 T11229 themeOf expression,inhibit
R8989 T11298 T11300 themeOf JNK,inhibition
R8990 T11232 T11233 themeOf CXCL8,expression
R8991 T11233 T11234 themeOf expression,elevated
R8992 T11235 T11237 themeOf CXCL8,expression
R8993 T11236 T11238 themeOf NF-κB,down-regulation
R8994 T11239 T11241 themeOf IL-6,expression
R8995 T11239 T11243 themeOf IL-6,regulated
R8996 T11301 T11302 themeOf PKC,inhibition
R8997 T11240 T11242 themeOf TNF,expression
R8998 T11241 T11244 themeOf expression,regulated
R8999 T11242 T11245 themeOf expression,regulated
R9000 T11247 T11251 themeOf PKC,associated
R9001 T11305 T11306 themeOf CXCL8,expression
R9002 T11248 T11252 themeOf AP-1,activation
R9003 T11249 T11253 themeOf NF-κB,activation
R9004 T11250 T11254 themeOf IL-2 promoter [45],activation
R9005 T11255 T11260 themeOf NF-κB site,Mutation
R9006 T11306 T11307 themeOf expression,required
R9007 T11256 T11261 themeOf IL-2,expression
R9008 T11257 T11262 themeOf AP-1 site,mutation
R9009 T11258 T11263 themeOf PKC,depletion
R9010 T11308 T11312 causeOf transcription factor NF-κB,inhibiting
R9011 T11309 T11311 themeOf IκB,transcription
R9012 T11259 T11264 themeOf IL-2 release,revoked
R9013 T11260 T11265 causeOf Mutation,affect
R9014 T11310 T11312 themeOf NF-κB,inhibiting
R9015 T11261 T11265 themeOf expression,affect
R9016 T11263 T11264 causeOf depletion,revoked
R9017 T11311 T11313 themeOf transcription,increase
R9018 T11314 T11317 themeOf NF-κB,Activation
R9019 T11269 T11270 themeOf MAPK,regulated
R9020 T11315 T11318 themeOf Bcl10,activation
R9021 T11271 T11275 themeOf NF-κB,inhibitor
R9022 T11316 T11319 causeOf PKC,regulated
R9023 T11273 T11276 themeOf IL-6,inhibition
R9024 T11318 T11319 themeOf activation,regulated
R9025 T11277 T11279 themeOf CXCL8,regulated
R9026 T11323 T11324 themeOf NF-κB,induction
R9027 T11278 T11280 themeOf CXCL8,expression
R9028 T11280 T11281 themeOf expression,reduction
R9029 T11282 T11285 themeOf CXCL8,expression
R9030 T11285 T11286 themeOf expression,affected
R9031 T11324 T11325 themeOf induction,importance
R9032 T11287 T11293 themeOf CXCL8,expression
R9033 T11288 T11294 themeOf PKC,inhibitors
R9034 T11327 T11332 themeOf Bcl10,Down-regulation
R9035 T11289 T11295 themeOf JNK,inhibitors
R9036 T11290 T11296 themeOf AP-1,involvement
R9037 T11331 T11333 themeOf NF-κB,down-regulation
R9038 T11297 T11299 themeOf NF-κB,inhibition
R9039 T11332 T11333 causeOf Down-regulation,down-regulation
R9040 T11334 T11337 themeOf Bcl10,activated
R9041 T11385 T11386 themeOf CXCL8,Elevated
R9042 T11334 T11338 themeOf Bcl10,activated
R9043 T11335 T11337 causeOf TCR,activated
R9044 T11387 T11388 themeOf CXCL8,elevated
R9045 T11336 T11338 causeOf PKC,activated
R9046 T11340 T11341 themeOf NF-κB,activation
R9047 T11342 T11346 themeOf NF-κB,activation
R9048 T11343 T11347 themeOf Akt,activation
R9049 T11348 T11350 themeOf Akt,phosphorylates
R9050 T11348 T11351 causeOf Akt,activates
R9051 T11349 T11351 themeOf Bcl10,activates
R9052 T11352 T11357 causeOf PKC,crucial
R9053 T11353 T11356 themeOf NF-κB,activation
R9054 T11356 T11357 themeOf activation,crucial
R9055 T11359 T11360 themeOf PKC,activates
R9056 T11363 T11364 themeOf PKC,regulation
R9057 T11365 T11366 themeOf PKC,activated
R9058 T11367 T11371 themeOf PKC,phosphorylated
R9059 T11367 T11372 themeOf PKC,regulated
R9060 T11371 T11373 themeOf phosphorylated,regulated
R9061 T11374 T11375 themeOf Bcl10,down-regulated
R9062 T11377 T11380 themeOf PKC,activation
R9063 T11378 T11381 themeOf Bcl10,inhibition
R9064 T11379 T11382 themeOf NF-κB,inhibition

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T6703 282-286 Protein denotes IL-6
T6704 291-296 Protein denotes CXCL8
T6705 297-307 Regulation denotes regulation true
T6706 297-307 Regulation denotes regulation true
T6707 1301-1310 Regulation denotes dependent
T6708 1301-1310 Regulation denotes dependent
T6709 1311-1322 Protein_catabolism denotes degradation
T6710 1311-1322 Protein_catabolism denotes degradation
T6711 1326-1338 Protein denotes IκB kinase β
T6712 1343-1344 Protein denotes γ
T6713 1345-1359 Positive_regulation denotes in response to
T6714 1345-1359 Positive_regulation denotes in response to
T6715 1543-1553 Gene_expression denotes expression
T6716 1557-1561 Protein denotes IL-6
T6717 1562-1571 Positive_regulation denotes following
T6718 1768-1787 Negative_regulation denotes negatively regulate
T6719 1788-1793 Protein denotes c-Rel
T6720 1998-2002 Protein denotes IL-2
T6721 2004-2008 Protein denotes IL-6
T6722 2010-2015 Protein denotes CXCL8
T6723 2025-2030 Protein denotes IL-10
T6724 2165-2173 Positive_regulation denotes enhanced
T6725 2174-2178 Protein denotes IL-2
T6726 2179-2189 Gene_expression denotes expression
T6727 2225-2228 Positive_regulation denotes due
T6728 2347-2351 Protein denotes IL-6
T6729 2389-2399 Regulation denotes regulation
T6730 2461-2466 Protein denotes CXCL8
T6731 2467-2477 Gene_expression denotes expression
T6732 2551-2555 Protein denotes IL-6
T6733 2560-2565 Protein denotes CXCL8
T6734 2571-2581 Gene_expression denotes expression
T6735 2571-2581 Gene_expression denotes expression
T6736 2719-2728 Positive_regulation denotes increases
T6737 2732-2736 Protein denotes IL-6
T6738 2766-2776 Positive_regulation denotes activating
T6739 2777-2782 Protein denotes CXCL8
T6740 2783-2790 Localization denotes release
T6741 2965-2970 Protein denotes ATF-2
T6742 3020-3040 Regulation denotes showed no difference true
T6743 3044-3049 Protein denotes IL-10
T6744 3050-3060 Gene_expression denotes expression
T6745 3153-3162 Negative_regulation denotes reduction
T6746 3166-3171 Protein denotes IL-10
T6747 3172-3182 Gene_expression denotes expression
T6748 3215-3220 Protein denotes IL-10
T6749 3332-3336 Protein denotes IL-2
T6750 3338-3342 Protein denotes IL-5
T6751 3347-3352 Protein denotes INF-γ
T6752 3529-3534 Protein denotes CXCL8
T6753 3765-3769 Protein denotes IL-6
T6754 3778-3788 Gene_expression denotes expression
T6755 3794-3806 Positive_regulation denotes up regulated
T6756 3974-3984 Positive_regulation denotes activation
T6757 3992-3996 Protein denotes IL-2
T6758 3997-4005 Entity denotes promoter
T6759 4012-4020 Regulation denotes Mutation
T6760 4028-4038 Entity denotes NF-κB site
T6761 4047-4053 Regulation denotes affect true
T6762 4054-4058 Protein denotes IL-2
T6763 4059-4069 Gene_expression denotes expression
T6764 4079-4087 Regulation denotes mutation
T6765 4095-4104 Entity denotes AP-1 site
T6766 4129-4136 Negative_regulation denotes revoked
T6767 4137-4141 Protein denotes IL-2
T6768 4142-4149 Localization denotes release
T6769 4495-4503 Positive_regulation denotes resulted
T6770 4495-4503 Positive_regulation denotes resulted
T6771 4518-4522 Protein denotes IL-6
T6772 4523-4533 Negative_regulation denotes inhibition
T6773 4544-4553 Positive_regulation denotes induction
T6774 4579-4583 Protein denotes IL-6
T6775 4584-4593 Negative_regulation denotes reduction
T6776 4703-4712 Negative_regulation denotes reduction
T6777 4716-4721 Protein denotes CXCL8
T6778 4722-4732 Gene_expression denotes expression
T6779 4747-4752 Protein denotes CXCL8
T6780 4753-4763 Gene_expression denotes expression
T6781 4772-4780 Regulation denotes affected true
T6782 4788-4797 Positive_regulation denotes following
T6783 4861-4866 Protein denotes CXCL8
T6784 4898-4903 Protein denotes CXCL8
T6785 4904-4914 Gene_expression denotes expression
T6786 4926-4941 Negative_regulation denotes down-regulation
T6787 4985-4996 Regulation denotes involvement
T6788 5005-5008 Positive_regulation denotes via true
T6789 5087-5091 Protein denotes il-6
T6790 5096-5101 Protein denotes cxcl8
T6791 5107-5118 Positive_regulation denotes upregulated
T6792 5107-5118 Positive_regulation denotes upregulated
T6793 5127-5137 Gene_expression denotes Expression
T6794 5141-5145 Protein denotes il-6
T6795 5146-5153 Negative_regulation denotes dropped
T6796 5219-5224 Protein denotes cxcl8
T6797 5225-5242 Negative_regulation denotes remained elevated true
T6798 5393-5401 Negative_regulation denotes decrease true
T6799 5393-5401 Negative_regulation denotes decrease true
T6800 5405-5409 Protein denotes il-6
T6801 5413-5418 Protein denotes cxcl8
T6802 5509-5517 Regulation denotes involved true
T6803 5509-5517 Regulation denotes involved true
T6804 5521-5525 Protein denotes IL-6
T6805 5526-5536 Regulation denotes regulation
T6806 5541-5548 Localization denotes release
T6807 5565-5573 Regulation denotes required true true
T6808 5582-5592 Gene_expression denotes expression
T6809 5596-5601 Protein denotes CXCL8
T6810 5834-5839 Protein denotes Bcl10
T6811 5840-5850 Positive_regulation denotes activation
T6812 5869-5878 Regulation denotes regulated
T6813 5969-5975 Protein denotes CARMA1
T6814 5977-5982 Protein denotes Bcl10
T6815 5987-5992 Protein denotes MALT1
T6816 6041-6046 Protein denotes Bcl10
T6817 6145-6160 Negative_regulation denotes Down-regulation
T6818 6164-6169 Protein denotes Bcl10
T6819 6206-6210 Protein denotes CD28
T6820 6291-6296 Protein denotes Bcl10
T6821 6310-6319 Positive_regulation denotes activated true
T6822 6368-6376 Positive_regulation denotes promotes
T6823 6381-6392 Protein_catabolism denotes degradation
T6824 6437-6445 Negative_regulation denotes deletion
T6825 6437-6445 Negative_regulation denotes deletion
T6826 6437-6445 Negative_regulation denotes deletion
T6827 6594-6600 Protein denotes CARMA1
T6828 6705-6719 Phosphorylation denotes phosphorylates
T6829 6729-6738 Positive_regulation denotes activates
T6830 6739-6744 Protein denotes Bcl10
T6831 6934-6938 Protein denotes CD28
T6832 7648-7653 Protein denotes Bcl10
T6833 7666-7680 Negative_regulation denotes down-regulated
T6834 7763-7767 Negative_regulation denotes loss
T6835 7771-7776 Protein denotes Bcl10
T6836 7812-7820 Positive_regulation denotes increase
T6837 8006-8011 Positive_regulation denotes leads
T6838 8018-8028 Negative_regulation denotes inhibition
T6839 8032-8037 Protein denotes Bcl10
T6840 8383-8391 Positive_regulation denotes Elevated
T6841 8392-8397 Protein denotes CXCL8
T6842 8648-8653 Protein denotes CXCL8
T6843 8665-8673 Positive_regulation denotes elevated
R5312 T6703 T6706 themeOf IL-6,regulation
R5313 T6704 T6705 themeOf CXCL8,regulation
R5314 T6707 T6714 themeOf dependent,in response to
R5315 T6708 T6713 themeOf dependent,in response to
R5316 T6709 T6708 themeOf degradation,dependent
R5318 T6711 T6710 themeOf IκB kinase β,degradation
R5319 T6712 T6709 themeOf γ,degradation
R5320 T6715 T6717 themeOf expression,following
R5321 T6716 T6715 themeOf IL-6,expression
R5322 T6719 T6718 themeOf c-Rel,negatively regulate
R5323 T6724 T6727 themeOf enhanced,due
R5324 T6725 T6726 themeOf IL-2,expression
R5325 T6726 T6724 themeOf expression,enhanced
R5326 T6728 T6729 themeOf IL-6,regulation
R5327 T6730 T6731 themeOf CXCL8,expression
R5328 T6732 T6735 themeOf IL-6,expression
R5329 T6733 T6734 themeOf CXCL8,expression
R5330 T6737 T6736 themeOf IL-6,increases
R5331 T6739 T6740 themeOf CXCL8,release
R5332 T6740 T6738 themeOf release,activating
R5333 T6743 T6744 themeOf IL-10,expression
R5334 T6744 T6742 themeOf expression,showed no difference
R5335 T6746 T6747 themeOf IL-10,expression
R5336 T6747 T6745 themeOf expression,reduction
R5337 T6753 T6754 themeOf IL-6,expression
R5338 T6754 T6755 themeOf expression,up regulated
R5339 T6758 T6756 themeOf promoter,activation
R5340 T6758 T6757 partOf promoter,IL-2
R5341 T6759 T6761 causeOf Mutation,affect
R5342 T6760 T6759 themeOf NF-κB site,Mutation
R5343 T6760 T6762 partOf NF-κB site,IL-2
R5344 T6762 T6763 themeOf IL-2,expression
R5345 T6763 T6761 themeOf expression,affect
R5346 T6764 T6766 causeOf mutation,revoked
R5347 T6765 T6764 themeOf AP-1 site,mutation
R5348 T6765 T6767 partOf AP-1 site,IL-2
R5349 T6767 T6768 themeOf IL-2,release
R5350 T6768 T6766 themeOf release,revoked
R5351 T6771 T6772 themeOf IL-6,inhibition
R5352 T6771 T6773 themeOf IL-6,induction
R5353 T6772 T6769 themeOf inhibition,resulted
R5354 T6774 T6775 themeOf IL-6,reduction
R5355 T6775 T6770 themeOf reduction,resulted
R5356 T6777 T6778 themeOf CXCL8,expression
R5357 T6778 T6776 themeOf expression,reduction
R5358 T6779 T6780 themeOf CXCL8,expression
R5359 T6780 T6781 themeOf expression,affected
R5360 T6780 T6782 themeOf expression,following
R5361 T6784 T6785 themeOf CXCL8,expression
R5362 T6785 T6786 themeOf expression,down-regulation
R5363 T6785 T6787 themeOf expression,involvement
R5364 T6787 T6788 themeOf involvement,via
R5365 T6789 T6791 themeOf il-6,upregulated
R5366 T6790 T6792 themeOf cxcl8,upregulated
R5367 T6793 T6795 themeOf Expression,dropped
R5368 T6794 T6793 themeOf il-6,Expression
R5369 T6796 T6797 themeOf cxcl8,remained elevated
R5370 T6800 T6799 themeOf il-6,decrease
R5371 T6801 T6798 themeOf cxcl8,decrease
R5372 T6804 T6805 themeOf IL-6,regulation
R5373 T6804 T6806 themeOf IL-6,release
R5374 T6805 T6803 themeOf regulation,involved
R5375 T6806 T6802 themeOf release,involved
R5376 T6808 T6807 themeOf expression,required
R5377 T6809 T6808 themeOf CXCL8,expression
R5378 T6810 T6811 themeOf Bcl10,activation
R5379 T6811 T6812 themeOf activation,regulated
R5380 T6813 T6825 themeOf CARMA1,deletion
R5381 T6814 T6824 themeOf Bcl10,deletion
R5382 T6815 T6826 themeOf MALT1,deletion
R5383 T6818 T6817 themeOf Bcl10,Down-regulation
R5384 T6819 T6817 causeOf CD28,Down-regulation
R5385 T6820 T6821 themeOf Bcl10,activated
R5386 T6820 T6823 themeOf Bcl10,degradation
R5387 T6821 T6822 causeOf activated,promotes
R5388 T6823 T6822 themeOf degradation,promotes
R5389 T6830 T6828 themeOf Bcl10,phosphorylates
R5390 T6830 T6829 themeOf Bcl10,activates
R5391 T6832 T6833 themeOf Bcl10,down-regulated
R5392 T6835 T6834 themeOf Bcl10,loss
R5393 T6835 T6836 themeOf Bcl10,increase
R5317 T6710 T6707 themeOf degradation,dependent
R5394 T6838 T6837 themeOf inhibition,leads
R5395 T6839 T6838 themeOf Bcl10,inhibition
R5396 T6841 T6840 themeOf CXCL8,Elevated
R5397 T6842 T6843 themeOf CXCL8,elevated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T9919 21-25 P05412 denotes AP-1
T9920 238-241 P26358 denotes aim
T9921 282-286 P05231 denotes IL-6
T9922 291-296 P10145 denotes CXCL8
T9923 321-325 P05412 denotes AP-1
T9924 387-391 P05412 denotes AP-1
T9925 506-510 P05412 denotes AP-1
T9926 772-776 P05412 denotes AP-1
T9927 908-912 P05412 denotes AP-1
T9928 1326-1336 O15111 denotes IκB kinase
T9929 1326-1336 Q60680-2 denotes IκB kinase
T9930 1447-1451 P05412 denotes AP-1
T9931 1557-1561 P05231 denotes IL-6
T9932 1788-1793 Q04864 denotes c-Rel
T9933 1790-1793 Q04864 denotes Rel
T9934 1843-1847 P05412 denotes AP-1
T9935 1998-2002 P60568 denotes IL-2
T9936 2004-2008 P05231 denotes IL-6
T9937 2010-2015 P10145 denotes CXCL8
T9938 2017-2020 P01375 denotes TNF
T9939 2025-2030 P22301 denotes IL-10
T9940 2174-2178 P60568 denotes IL-2
T9941 2300-2304 P05412 denotes AP-1
T9942 2347-2351 P05231 denotes IL-6
T9943 2406-2410 P05412 denotes AP-1
T9944 2461-2466 P10145 denotes CXCL8
T9945 2551-2555 P05231 denotes IL-6
T9946 2560-2565 P10145 denotes CXCL8
T9947 2732-2736 P05231 denotes IL-6
T9948 2777-2782 P10145 denotes CXCL8
T9949 2834-2837 P01375 denotes TNF
T9950 2850-2853 P01375 denotes TNF
T9951 2965-2970 P15336 denotes ATF-2
T9952 2971-2974 P05412 denotes Jun
T9953 3044-3049 P22301 denotes IL-10
T9954 3166-3171 P22301 denotes IL-10
T9955 3215-3220 P22301 denotes IL-10
T9956 3332-3336 P60568 denotes IL-2
T9957 3338-3342 P05113 denotes IL-5
T9958 3506-3510 P05412 denotes AP-1
T9959 3529-3534 P10145 denotes CXCL8
T9960 3541-3546 P10145 denotes CXCL8
T9961 3626-3631 P10145 denotes CXCL8
T9962 3765-3769 P05231 denotes IL-6
T9963 3774-3777 P01375 denotes TNF
T9964 3949-3953 P05412 denotes AP-1
T9965 3992-3996 P60568 denotes IL-2
T9966 4054-4058 P60568 denotes IL-2
T9967 4095-4099 P05412 denotes AP-1
T9968 4137-4141 P60568 denotes IL-2
T9969 4230-4234 P05412 denotes AP-1
T9970 4365-4370 P10145 denotes CXCL8
T9971 4518-4522 P05231 denotes IL-6
T9972 4579-4583 P05231 denotes IL-6
T9973 4622-4627 P10145 denotes CXCL8
T9974 4716-4721 P10145 denotes CXCL8
T9975 4747-4752 P10145 denotes CXCL8
T9976 4861-4866 P10145 denotes CXCL8
T9977 4898-4903 P10145 denotes CXCL8
T9978 5000-5004 P05412 denotes AP-1
T9979 5087-5091 P05231 denotes il-6
T9980 5096-5101 P10145 denotes cxcl8
T9981 5141-5145 P05231 denotes il-6
T9982 5219-5224 P10145 denotes cxcl8
T9983 5405-5409 P05231 denotes il-6
T9984 5413-5418 P10145 denotes cxcl8
T9985 5521-5525 P05231 denotes IL-6
T9986 5596-5601 P10145 denotes CXCL8
T9987 5834-5839 O95999 denotes Bcl10
T9988 5969-5975 Q9BXL7 denotes CARMA1
T9989 5977-5982 O95999 denotes Bcl10
T9990 5987-5992 Q9UDY8 denotes MALT1
T9991 6041-6046 O95999 denotes Bcl10
T9992 6164-6169 O95999 denotes Bcl10
T9993 6206-6210 P10747 denotes CD28
T9994 6291-6296 O95999 denotes Bcl10
T9995 6581-6584 Q9Y243 denotes Akt
T9996 6581-6584 P31749 denotes Akt
T9997 6581-6584 P31751 denotes Akt
T9998 6594-6600 Q9BXL7 denotes CARMA1
T9999 6701-6704 P31749 denotes Akt
T10000 6701-6704 Q9Y243 denotes Akt
T10001 6701-6704 P31751 denotes Akt
T10002 6739-6744 O95999 denotes Bcl10
T10003 6934-6938 P10747 denotes CD28
T10004 7194-7198 P05412 denotes AP-1
T10005 7632-7636 P05412 denotes AP-1
T10006 7648-7653 O95999 denotes Bcl10
T10007 7771-7776 O95999 denotes Bcl10
T10008 8032-8037 O95999 denotes Bcl10
T10009 8392-8397 P10145 denotes CXCL8
T10010 8648-8653 P10145 denotes CXCL8

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T6565 282-286 Protein denotes IL-6 true
T6566 291-296 Protein denotes CXCL8 true
T6567 297-307 Regulation denotes regulation
T6568 1301-1310 Regulation denotes dependent
T6569 1311-1322 Protein_catabolism denotes degradation
T6570 1326-1338 Protein denotes IκB kinase β
T6571 1343-1344 Protein denotes γ
T6572 1345-1359 Positive_regulation denotes in response to
T6573 1543-1553 Gene_expression denotes expression
T6574 1557-1561 Protein denotes IL-6
T6575 1562-1571 Positive_regulation denotes following
T6576 1779-1787 Regulation denotes regulate
T6577 1788-1793 Protein denotes c-Rel
T6578 1998-2002 Protein denotes IL-2
T6579 2004-2008 Protein denotes IL-6
T6580 2010-2015 Protein denotes CXCL8
T6581 2025-2030 Protein denotes IL-10
T6582 2165-2173 Positive_regulation denotes enhanced
T6583 2174-2178 Protein denotes IL-2
T6584 2179-2189 Gene_expression denotes expression
T6585 2347-2351 Protein denotes IL-6
T6586 2452-2460 Regulation denotes regulate true
T6587 2461-2466 Protein denotes CXCL8
T6588 2467-2477 Gene_expression denotes expression
T6589 2551-2555 Protein denotes IL-6
T6590 2560-2565 Protein denotes CXCL8
T6591 2571-2581 Gene_expression denotes expression
T6592 2719-2728 Positive_regulation denotes increases
T6593 2732-2736 Protein denotes IL-6
T6594 2766-2776 Positive_regulation denotes activating true
T6595 2777-2782 Protein denotes CXCL8
T6596 2783-2790 Localization denotes release
T6597 2826-2833 Positive_regulation denotes induced
T6598 2838-2848 Gene_expression denotes expression
T6599 2884-2891 Positive_regulation denotes induced
T6600 2916-2926 Gene_expression denotes expression
T6601 2930-2939 Regulation denotes regulated
T6602 2965-2970 Protein denotes ATF-2
T6603 3030-3040 Regulation denotes difference
T6604 3044-3049 Protein denotes IL-10
T6605 3050-3060 Gene_expression denotes expression
T6606 3075-3082 Positive_regulation denotes induced
T6607 3127-3135 Positive_regulation denotes resulted true
T6608 3153-3162 Negative_regulation denotes reduction
T6609 3166-3171 Protein denotes IL-10
T6610 3172-3182 Gene_expression denotes expression
T6611 3215-3220 Protein denotes IL-10
T6612 3332-3336 Protein denotes IL-2 true
T6613 3338-3342 Protein denotes IL-5
T6614 3347-3352 Protein denotes INF-γ
T6615 3529-3534 Protein denotes CXCL8
T6616 3547-3557 Gene_expression denotes expression
T6617 3576-3584 Positive_regulation denotes elevated true
T6618 3632-3642 Gene_expression denotes expression true
T6619 3765-3769 Protein denotes IL-6 true
T6620 3778-3788 Gene_expression denotes expression true
T6621 3794-3806 Positive_regulation denotes up regulated
T6622 3974-3984 Positive_regulation denotes activation true
T6623 3992-3996 Protein denotes IL-2
T6624 4030-4031 Entity denotes - true true
T6625 4047-4053 Regulation denotes affect
T6626 4054-4058 Protein denotes IL-2
T6627 4059-4069 Gene_expression denotes expression
T6628 4079-4087 Negative_regulation denotes mutation
T6629 4095-4104 Entity denotes AP-1 site true
T6630 4129-4136 Negative_regulation denotes revoked
T6631 4137-4141 Protein denotes IL-2
T6632 4142-4149 Localization denotes release
T6633 4385-4394 Regulation denotes regulated
T6634 4495-4503 Positive_regulation denotes resulted
T6635 4518-4522 Protein denotes IL-6
T6636 4523-4533 Negative_regulation denotes inhibition
T6637 4544-4553 Positive_regulation denotes induction
T6638 4579-4583 Protein denotes IL-6
T6639 4584-4593 Negative_regulation denotes reduction
T6640 4639-4651 Positive_regulation denotes up regulated
T6641 4683-4691 Positive_regulation denotes resulted
T6642 4703-4712 Negative_regulation denotes reduction
T6643 4716-4721 Protein denotes CXCL8
T6644 4722-4732 Gene_expression denotes expression
T6645 4747-4752 Protein denotes CXCL8
T6646 4753-4763 Gene_expression denotes expression
T6647 4772-4780 Regulation denotes affected
T6648 4788-4797 Positive_regulation denotes following
T6649 4833-4837 Negative_regulation denotes lack
T6650 4861-4866 Protein denotes CXCL8
T6651 4898-4903 Protein denotes CXCL8
T6652 4904-4914 Gene_expression denotes expression
T6653 4926-4941 Negative_regulation denotes down-regulation
T6654 5087-5091 Protein denotes il-6
T6680 6206-6210 Protein denotes CD28
T6681 6291-6296 Protein denotes Bcl10
T6682 6310-6319 Positive_regulation denotes activated
T6683 6368-6376 Positive_regulation denotes promotes
T6684 6381-6392 Protein_catabolism denotes degradation
T6685 6594-6600 Protein denotes CARMA1
T6686 6705-6719 Phosphorylation denotes phosphorylates
T6687 6729-6738 Positive_regulation denotes activates
T6688 6739-6744 Protein denotes Bcl10
T6689 6934-6938 Protein denotes CD28
T6690 7578-7589 Binding denotes association
T6691 7648-7653 Protein denotes Bcl10
T6692 7666-7680 Negative_regulation denotes down-regulated
T6693 7763-7767 Negative_regulation denotes loss
T6694 7771-7776 Protein denotes Bcl10
T6695 7812-7820 Positive_regulation denotes increase
T6696 8018-8028 Negative_regulation denotes inhibition
T6697 8032-8037 Protein denotes Bcl10
T6698 8383-8391 Positive_regulation denotes Elevated
T6699 8392-8397 Protein denotes CXCL8
T6700 8648-8653 Protein denotes CXCL8
T6701 8665-8673 Positive_regulation denotes elevated
T6655 5096-5101 Protein denotes cxcl8
T6656 5127-5137 Gene_expression denotes Expression
T6657 5141-5145 Protein denotes il-6
T6658 5219-5224 Protein denotes cxcl8
T6659 5234-5242 Positive_regulation denotes elevated
T6660 5393-5401 Negative_regulation denotes decrease
T6661 5405-5409 Protein denotes il-6
T6662 5413-5418 Protein denotes cxcl8
T6663 5509-5517 Regulation denotes involved
T6664 5521-5525 Protein denotes IL-6
T6665 5526-5536 Regulation denotes regulation
T6666 5541-5548 Localization denotes release
T6667 5565-5573 Positive_regulation denotes required
T6668 5582-5592 Gene_expression denotes expression
T6669 5596-5601 Protein denotes CXCL8
T6670 5821-5830 Regulation denotes dependent
T6671 5834-5839 Protein denotes Bcl10
T6672 5840-5850 Positive_regulation denotes activation
T6673 5869-5878 Regulation denotes regulated
T6674 5969-5975 Protein denotes CARMA1
T6675 5977-5982 Protein denotes Bcl10
T6676 5987-5992 Protein denotes MALT1
T6677 6041-6046 Protein denotes Bcl10
T6678 6145-6160 Negative_regulation denotes Down-regulation
T6679 6164-6169 Protein denotes Bcl10
R5235 T6565 T6567 themeOf IL-6,regulation
R5236 T6566 T6567 themeOf CXCL8,regulation
R5237 T6568 T6572 themeOf dependent,in response to
R5238 T6569 T6568 themeOf degradation,dependent
R5239 T6569 T6572 themeOf degradation,in response to
R5240 T6570 T6569 themeOf IκB kinase β,degradation
R5241 T6570 T6572 themeOf IκB kinase β,in response to
R5242 T6571 T6569 themeOf γ,degradation
R5243 T6573 T6575 themeOf expression,following
R5244 T6574 T6573 themeOf IL-6,expression
R5245 T6577 T6576 themeOf c-Rel,regulate
R5246 T6583 T6584 themeOf IL-2,expression
R5247 T6584 T6582 themeOf expression,enhanced
R5248 T6587 T6588 themeOf CXCL8,expression
R5249 T6588 T6586 themeOf expression,regulate
R5250 T6589 T6591 themeOf IL-6,expression
R5251 T6590 T6591 themeOf CXCL8,expression
R5252 T6593 T6592 themeOf IL-6,increases
R5253 T6595 T6596 themeOf CXCL8,release
R5254 T6596 T6594 themeOf release,activating
R5255 T6598 T6597 themeOf expression,induced
R5256 T6600 T6601 themeOf expression,regulated
R5257 T6602 T6601 causeOf ATF-2,regulated
R5258 T6604 T6605 themeOf IL-10,expression
R5259 T6605 T6603 themeOf expression,difference
R5260 T6609 T6610 themeOf IL-10,expression
R5261 T6610 T6608 themeOf expression,reduction
R5262 T6616 T6617 themeOf expression,elevated
R5263 T6619 T6620 themeOf IL-6,expression
R5264 T6620 T6621 themeOf expression,up regulated
R5265 T6626 T6627 themeOf IL-2,expression
R5266 T6627 T6625 themeOf expression,affect
R5267 T6629 T6628 themeOf AP-1 site,mutation
R5268 T6629 T6631 partOf AP-1 site,IL-2
R5269 T6631 T6632 themeOf IL-2,release
R5270 T6632 T6630 themeOf release,revoked
R5271 T6635 T6636 themeOf IL-6,inhibition
R5272 T6635 T6637 themeOf IL-6,induction
R5273 T6636 T6634 themeOf inhibition,resulted
R5274 T6637 T6634 themeOf induction,resulted
R5275 T6638 T6639 themeOf IL-6,reduction
R5276 T6639 T6634 themeOf reduction,resulted
R5277 T6643 T6644 themeOf CXCL8,expression
R5278 T6644 T6642 themeOf expression,reduction
R5279 T6645 T6646 themeOf CXCL8,expression
R5280 T6646 T6647 themeOf expression,affected
R5281 T6646 T6648 themeOf expression,following
R5282 T6650 T6649 themeOf CXCL8,lack
R5283 T6651 T6652 themeOf CXCL8,expression
R5284 T6652 T6653 themeOf expression,down-regulation
R5285 T6657 T6656 themeOf il-6,Expression
R5286 T6661 T6660 themeOf il-6,decrease
R5287 T6662 T6660 themeOf cxcl8,decrease
R5288 T6664 T6666 themeOf IL-6,release
R5289 T6664 T6665 themeOf IL-6,regulation
R5290 T6665 T6663 themeOf regulation,involved
R5291 T6666 T6663 themeOf release,involved
R5292 T6666 T6667 causeOf release,required
R5293 T6668 T6667 themeOf expression,required
R5294 T6669 T6668 themeOf CXCL8,expression
R5295 T6671 T6672 themeOf Bcl10,activation
R5296 T6672 T6673 themeOf activation,regulated
R5297 T6679 T6678 themeOf Bcl10,Down-regulation
R5298 T6680 T6678 causeOf CD28,Down-regulation
R5299 T6681 T6682 themeOf Bcl10,activated
R5300 T6681 T6684 themeOf Bcl10,degradation
R5301 T6681 T6683 causeOf Bcl10,promotes
R5302 T6682 T6683 causeOf activated,promotes
R5303 T6684 T6683 themeOf degradation,promotes
R5304 T6686 T6687 causeOf phosphorylates,activates
R5305 T6688 T6687 themeOf Bcl10,activates
R5306 T6691 T6692 themeOf Bcl10,down-regulated
R5307 T6694 T6695 themeOf Bcl10,increase
R5308 T6694 T6693 themeOf Bcl10,loss
R5309 T6697 T6696 themeOf Bcl10,inhibition
R5310 T6699 T6698 themeOf CXCL8,Elevated
R5311 T6700 T6701 themeOf CXCL8,elevated