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PMC:2889865 / 12155-12924 JSONTXT

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bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T16309 279-289 Anaphor denotes the levels
T16310 197-207 Antecedent denotes expression
R13287 T16309 T16310 boundBy the levels,expression

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T16168 10-21 NN denotes Involvement
T16169 22-24 IN denotes of
T16170 25-30 NN denotes NF-κB
T16171 31-33 IN denotes in
T16172 34-42 NN denotes cytokine
T16173 43-53 NN denotes regulation
T16174 53-54 . denotes .
T16175 55-73 JJ denotes Cytokine/chemokine
T16176 74-80 NNS denotes levels
T16177 81-85 VBD denotes were
T16178 86-96 VBN denotes determined
T16179 97-102 VBG denotes using
T16180 103-108 NNP denotes ELISA
T16181 109-118 VBG denotes following
T16182 119-129 NN denotes incubation
T16183 130-132 IN denotes of
T16184 133-139 NNP denotes Jurkat
T16185 140-147 NNS denotes T-cells
T16186 148-152 IN denotes with
T16187 153-156 NNP denotes NAI
T16188 157-158 -LRB- denotes (
T16189 158-159 CD denotes 1
T16190 160-161 NN denotes h
T16191 161-162 -RRB- denotes )
T16192 163-166 CC denotes and
T16193 167-178 NN denotes stimulation
T16194 179-180 -LRB- denotes (
T16195 180-182 CD denotes 24
T16196 183-184 NN denotes h
T16197 184-185 -RRB- denotes )
T16198 185-186 . denotes .
T16199 187-188 -LRB- denotes (
T16200 188-189 NNP denotes A
T16201 189-190 -RRB- denotes )
T16202 191-196 NNP denotes CXCL8
T16203 197-207 NN denotes expression
T16204 208-211 VBD denotes was
T16205 212-221 RB denotes partially
T16206 222-231 VBN denotes inhibited
T16207 232-241 VBG denotes following
T16208 242-245 NNP denotes PMA
T16209 246-257 NN denotes stimulation
T16210 258-259 -LRB- denotes (
T16211 259-263 NN denotes grey
T16212 264-268 NNS denotes bars
T16213 268-269 -RRB- denotes )
T16214 269-270 , denotes ,
T16215 271-278 IN denotes whereas
T16216 279-282 DT denotes the
T16217 283-289 NNS denotes levels
T16218 290-294 VBD denotes were
T16219 295-298 RB denotes not
T16220 299-306 VBN denotes altered
T16221 307-316 VBG denotes following
T16222 317-328 NN denotes stimulation
T16223 329-333 IN denotes with
T16224 334-336 NNP denotes HK
T16225 337-339 NNP denotes E.
T16226 340-344 NNS denotes coli
T16227 345-346 -LRB- denotes (
T16228 346-351 JJ denotes black
T16229 352-356 NNS denotes bars
T16230 356-357 -RRB- denotes )
T16231 357-358 , denotes ,
T16232 359-363 DT denotes this
T16233 364-373 VBZ denotes indicates
T16234 374-376 DT denotes an
T16235 377-386 NN denotes induction
T16236 387-393 RB denotes mainly
T16237 394-403 VBN denotes regulated
T16238 404-406 IN denotes by
T16239 407-411 NN denotes AP-1
T16240 411-412 . denotes .
T16241 413-414 -LRB- denotes (
T16242 414-415 NNP denotes B
T16243 415-416 -RRB- denotes )
T16244 417-420 NNP denotes TNF
T16245 421-431 NN denotes expression
T16246 432-435 VBD denotes was
T16247 436-439 RB denotes not
T16248 440-448 VBN denotes affected
T16249 449-451 IN denotes by
T16250 452-455 NNP denotes NAI
T16251 455-456 . denotes .
T16252 457-458 -LRB- denotes (
T16253 458-459 $ denotes C
T16254 459-460 -RRB- denotes )
T16255 461-465 NN denotes IL-6
T16256 466-473 NN denotes release
T16257 474-477 VBD denotes was
T16258 478-488 RB denotes completely
T16259 489-498 VBN denotes inhibited
T16260 499-501 IN denotes by
T16261 502-505 NNP denotes NAI
T16262 506-515 VBG denotes following
T16263 516-519 NNP denotes PMA
T16264 520-528 NN denotes exposure
T16265 528-529 , denotes ,
T16266 530-540 VBG denotes indicating
T16267 541-551 NN denotes regulation
T16268 552-559 IN denotes through
T16269 560-565 NNP denotes NF-κB
T16270 566-571 IN denotes since
T16271 572-576 NNP denotes IL-6
T16272 577-587 NN denotes expression
T16273 588-591 VBD denotes was
T16274 592-605 RB denotes significantly
T16275 606-615 VBN denotes increased
T16276 616-618 IN denotes in
T16277 619-627 NN denotes response
T16278 628-630 TO denotes to
T16279 631-633 NNP denotes HK
T16280 634-636 NNP denotes E.
T16281 637-641 NNS denotes coli
T16282 642-646 IN denotes than
T16283 647-650 NNP denotes PMA
T16284 650-651 . denotes .
T16285 652-663 NNP denotes Statistical
T16286 664-676 NN denotes significance
T16287 677-681 IN denotes from
T16288 682-685 DT denotes the
T16289 686-694 JJ denotes positive
T16290 695-702 NN denotes control
T16291 703-704 -LRB- denotes (
T16292 704-710 NNP denotes PMA/HK
T16293 711-713 NNP denotes E.
T16294 714-718 NNS denotes coli
T16295 718-719 -RRB- denotes )
T16296 720-723 VBD denotes was
T16297 724-734 VBN denotes determined
T16298 735-740 VBG denotes using
T16299 741-748 NN denotes Student
T16300 748-750 POS denotes 's
T16301 751-757 JJS denotes t-test
T16302 757-758 . denotes .
T16303 759-760 -LRB- denotes (
T16304 760-761 FW denotes n
T16305 762-763 SYM denotes =
T16306 764-765 LS denotes 3
T16307 765-766 -RRB- denotes )
T16308 766-767 . denotes .
R13146 T16168 T16168 ROOT Involvement,Involvement
R13147 T16169 T16168 prep of,Involvement
R13148 T16170 T16169 pobj NF-κB,of
R13149 T16171 T16168 prep in,Involvement
R13150 T16172 T16173 compound cytokine,regulation
R13151 T16173 T16171 pobj regulation,in
R13152 T16174 T16168 punct .,Involvement
R13153 T16175 T16176 amod Cytokine/chemokine,levels
R13154 T16176 T16178 nsubjpass levels,determined
R13155 T16177 T16178 auxpass were,determined
R13156 T16178 T16178 ROOT determined,determined
R13157 T16179 T16178 advcl using,determined
R13158 T16180 T16179 dobj ELISA,using
R13159 T16181 T16178 prep following,determined
R13160 T16182 T16181 pobj incubation,following
R13161 T16183 T16182 prep of,incubation
R13162 T16184 T16185 compound Jurkat,T-cells
R13163 T16185 T16183 pobj T-cells,of
R13164 T16186 T16182 prep with,incubation
R13165 T16187 T16186 pobj NAI,with
R13166 T16188 T16190 punct (,h
R13167 T16189 T16190 nummod 1,h
R13168 T16190 T16187 appos h,NAI
R13169 T16191 T16190 punct ),h
R13170 T16192 T16190 cc and,h
R13171 T16193 T16190 conj stimulation,h
R13172 T16194 T16196 punct (,h
R13173 T16195 T16196 nummod 24,h
R13174 T16196 T16190 appos h,h
R13175 T16197 T16190 punct ),h
R13176 T16198 T16178 punct .,determined
R13177 T16199 T16206 punct (,inhibited
R13178 T16200 T16203 nmod A,expression
R13179 T16201 T16200 punct ),A
R13180 T16202 T16203 compound CXCL8,expression
R13181 T16203 T16206 nsubjpass expression,inhibited
R13182 T16204 T16206 auxpass was,inhibited
R13183 T16205 T16206 advmod partially,inhibited
R13184 T16206 T16233 advcl inhibited,indicates
R13185 T16207 T16206 prep following,inhibited
R13186 T16208 T16209 compound PMA,stimulation
R13187 T16209 T16207 pobj stimulation,following
R13188 T16210 T16212 punct (,bars
R13189 T16211 T16212 amod grey,bars
R13190 T16212 T16209 appos bars,stimulation
R13191 T16213 T16206 punct ),inhibited
R13192 T16214 T16206 punct ",",inhibited
R13193 T16215 T16220 mark whereas,altered
R13194 T16216 T16217 det the,levels
R13195 T16217 T16220 nsubjpass levels,altered
R13196 T16218 T16220 auxpass were,altered
R13197 T16219 T16220 neg not,altered
R13198 T16220 T16206 advcl altered,inhibited
R13199 T16221 T16220 prep following,altered
R13200 T16222 T16221 pobj stimulation,following
R13201 T16223 T16222 prep with,stimulation
R13202 T16224 T16226 compound HK,coli
R13203 T16225 T16226 compound E.,coli
R13204 T16226 T16223 pobj coli,with
R13205 T16227 T16226 punct (,coli
R13206 T16228 T16229 amod black,bars
R13207 T16229 T16226 appos bars,coli
R13208 T16230 T16226 punct ),coli
R13209 T16231 T16233 punct ",",indicates
R13210 T16232 T16233 nsubj this,indicates
R13211 T16233 T16233 ROOT indicates,indicates
R13212 T16234 T16235 det an,induction
R13213 T16235 T16233 dobj induction,indicates
R13214 T16236 T16237 advmod mainly,regulated
R13215 T16237 T16235 acl regulated,induction
R13216 T16238 T16237 agent by,regulated
R13217 T16239 T16238 pobj AP-1,by
R13218 T16240 T16233 punct .,indicates
R13219 T16241 T16248 punct (,affected
R13220 T16242 T16245 nmod B,expression
R13221 T16243 T16242 punct ),B
R13222 T16244 T16245 compound TNF,expression
R13223 T16245 T16248 nsubjpass expression,affected
R13224 T16246 T16248 auxpass was,affected
R13225 T16247 T16248 neg not,affected
R13226 T16248 T16248 ROOT affected,affected
R13227 T16249 T16248 agent by,affected
R13228 T16250 T16249 pobj NAI,by
R13229 T16251 T16248 punct .,affected
R13230 T16252 T16253 punct (,C
R13231 T16253 T16253 ROOT C,C
R13232 T16254 T16253 punct ),C
R13233 T16255 T16256 compound IL-6,release
R13234 T16256 T16259 nsubjpass release,inhibited
R13235 T16257 T16259 auxpass was,inhibited
R13236 T16258 T16259 advmod completely,inhibited
R13237 T16259 T16259 ROOT inhibited,inhibited
R13238 T16260 T16259 agent by,inhibited
R13239 T16261 T16260 pobj NAI,by
R13240 T16262 T16259 prep following,inhibited
R13241 T16263 T16264 compound PMA,exposure
R13242 T16264 T16262 pobj exposure,following
R13243 T16265 T16259 punct ",",inhibited
R13244 T16266 T16259 advcl indicating,inhibited
R13245 T16267 T16266 dobj regulation,indicating
R13246 T16268 T16266 prep through,indicating
R13247 T16269 T16268 pobj NF-κB,through
R13248 T16270 T16275 mark since,increased
R13249 T16271 T16272 compound IL-6,expression
R13250 T16272 T16275 nsubjpass expression,increased
R13251 T16273 T16275 auxpass was,increased
R13252 T16274 T16275 advmod significantly,increased
R13253 T16275 T16266 advcl increased,indicating
R13254 T16276 T16275 prep in,increased
R13255 T16277 T16276 pobj response,in
R13256 T16278 T16277 prep to,response
R13257 T16279 T16281 compound HK,coli
R13258 T16280 T16281 compound E.,coli
R13259 T16281 T16278 pobj coli,to
R13260 T16282 T16275 prep than,increased
R13261 T16283 T16282 pobj PMA,than
R13262 T16284 T16259 punct .,inhibited
R13263 T16285 T16286 compound Statistical,significance
R13264 T16286 T16297 nsubjpass significance,determined
R13265 T16287 T16286 prep from,significance
R13266 T16288 T16290 det the,control
R13267 T16289 T16290 amod positive,control
R13268 T16290 T16287 pobj control,from
R13269 T16291 T16290 punct (,control
R13270 T16292 T16294 compound PMA/HK,coli
R13271 T16293 T16294 compound E.,coli
R13272 T16294 T16290 appos coli,control
R13273 T16295 T16290 punct ),control
R13274 T16296 T16297 auxpass was,determined
R13275 T16297 T16297 ROOT determined,determined
R13276 T16298 T16297 advcl using,determined
R13277 T16299 T16301 poss Student,t-test
R13278 T16300 T16299 case 's,Student
R13279 T16301 T16298 dobj t-test,using
R13280 T16302 T16297 punct .,determined
R13281 T16303 T16306 punct (,3
R13282 T16304 T16306 advmod n,3
R13283 T16305 T16306 punct =,3
R13284 T16306 T16306 ROOT 3,3
R13285 T16307 T16306 punct ),3
R13286 T16308 T16306 punct .,3

GO-BP

Id Subject Object Predicate Lexical cue
T16319 43-53 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16320 541-551 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

GO-MF

Id Subject Object Predicate Lexical cue
T16321 461-465 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T16322 572-576 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6

GO-CC

Id Subject Object Predicate Lexical cue
T16323 142-147 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T16165 10-54 Sentence denotes Involvement of NF-κB in cytokine regulation.
T16166 55-651 Sentence denotes Cytokine/chemokine levels were determined using ELISA following incubation of Jurkat T-cells with NAI (1 h) and stimulation (24 h). (A) CXCL8 expression was partially inhibited following PMA stimulation (grey bars), whereas the levels were not altered following stimulation with HK E. coli (black bars), this indicates an induction mainly regulated by AP-1. (B) TNF expression was not affected by NAI. (C) IL-6 release was completely inhibited by NAI following PMA exposure, indicating regulation through NF-κB since IL-6 expression was significantly increased in response to HK E. coli than PMA.
T16167 652-767 Sentence denotes Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 3).
T92 0-54 Sentence denotes Figure 5 Involvement of NF-κB in cytokine regulation.
T93 55-651 Sentence denotes Cytokine/chemokine levels were determined using ELISA following incubation of Jurkat T-cells with NAI (1 h) and stimulation (24 h). (A) CXCL8 expression was partially inhibited following PMA stimulation (grey bars), whereas the levels were not altered following stimulation with HK E. coli (black bars), this indicates an induction mainly regulated by AP-1. (B) TNF expression was not affected by NAI. (C) IL-6 release was completely inhibited by NAI following PMA exposure, indicating regulation through NF-κB since IL-6 expression was significantly increased in response to HK E. coli than PMA.
T94 652-767 Sentence denotes Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 3).

events-check-again

Id Subject Object Predicate Lexical cue Negation
T16383 191-196 Protein denotes CXCL8
T16384 197-207 Gene_expression denotes expression
T16385 222-231 Negative_regulation denotes inhibited
T16386 299-306 Regulation denotes altered true
T16387 377-386 Positive_regulation denotes induction
T16388 394-403 Regulation denotes regulated
T16389 461-465 Protein denotes IL-6
T16390 466-473 Localization denotes release
T16391 489-498 Negative_regulation denotes inhibited
T16392 541-551 Regulation denotes regulation
T16393 572-576 Protein denotes IL-6
T16394 577-587 Gene_expression denotes expression
T16395 606-615 Positive_regulation denotes increased
R13331 T16383 T16384 themeOf CXCL8,expression
R13332 T16384 T16385 themeOf expression,inhibited
R13333 T16384 T16386 themeOf expression,altered
R13334 T16384 T16387 themeOf expression,induction
R13335 T16387 T16388 themeOf induction,regulated
R13336 T16389 T16390 themeOf IL-6,release
R13337 T16390 T16392 themeOf release,regulation
R13338 T16390 T16391 themeOf release,inhibited
R13339 T16393 T16394 themeOf IL-6,expression
R13340 T16394 T16395 themeOf expression,increased

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T16396 25-30 Protein denotes NF-κB
T16397 43-53 Regulation denotes regulation
T16398 191-196 Protein denotes CXCL8
T16399 334-338 Protein denotes HK E
T16400 407-411 Protein denotes AP-1
T16401 197-207 Gene_expression denotes expression
T16402 222-231 Negative_regulation denotes inhibited
T16403 417-420 Protein denotes TNF
T16404 421-431 Gene_expression denotes expression
T16405 440-448 Regulation denotes affected
T16406 560-565 Protein denotes NF-κB
T16407 572-576 Protein denotes IL-6
T16408 631-633 Protein denotes HK
T16409 577-587 Gene_expression denotes expression
T16410 606-615 Positive_regulation denotes increased
T16411 541-551 Regulation denotes regulation
R13341 T16396 T16397 themeOf NF-κB,regulation
R13342 T16398 T16401 themeOf CXCL8,expression
R13343 T16401 T16402 themeOf expression,inhibited
R13344 T16403 T16404 themeOf TNF,expression
R13345 T16404 T16405 themeOf expression,affected
R13346 T16407 T16409 themeOf IL-6,expression
R13347 T16409 T16410 themeOf expression,increased
R13348 T16410 T16411 themeOf increased,regulation

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation
T16152 191-196 Protein denotes CXCL8
T16153 197-207 Gene_expression denotes expression
T16154 222-231 Negative_regulation denotes inhibited
T16155 299-306 Regulation denotes altered true
T16156 377-386 Positive_regulation denotes induction
T16157 394-403 Regulation denotes regulated
T16158 461-465 Protein denotes IL-6
T16159 466-473 Localization denotes release
T16160 489-498 Negative_regulation denotes inhibited
T16161 541-551 Regulation denotes regulation
T16162 572-576 Protein denotes IL-6
T16163 577-587 Gene_expression denotes expression
T16164 606-615 Positive_regulation denotes increased
R13136 T16152 T16153 themeOf CXCL8,expression
R13137 T16153 T16154 themeOf expression,inhibited
R13138 T16153 T16155 themeOf expression,altered
R13139 T16153 T16156 themeOf expression,induction
R13140 T16156 T16157 themeOf induction,regulated
R13141 T16158 T16159 themeOf IL-6,release
R13142 T16159 T16161 themeOf release,regulation
R13143 T16159 T16160 themeOf release,inhibited
R13144 T16162 T16163 themeOf IL-6,expression
R13145 T16163 T16164 themeOf expression,increased

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T16311 191-196 P10145 denotes CXCL8
T16312 407-411 P05412 denotes AP-1
T16313 417-420 P01375 denotes TNF
T16314 461-465 P05231 denotes IL-6
T16315 572-576 P05231 denotes IL-6

test2

Id Subject Object Predicate Lexical cue Negation
T16139 191-196 Protein denotes CXCL8
T16140 197-207 Gene_expression denotes expression
T16141 222-231 Negative_regulation denotes inhibited true
T16142 421-431 Gene_expression denotes expression
T16143 440-448 Regulation denotes affected
T16144 461-465 Protein denotes IL-6
T16145 466-473 Localization denotes release
T16146 489-498 Negative_regulation denotes inhibited
T16147 506-515 Positive_regulation denotes following
T16148 541-551 Regulation denotes regulation
T16149 572-576 Protein denotes IL-6
T16150 577-587 Gene_expression denotes expression
T16151 606-615 Positive_regulation denotes increased
R13126 T16139 T16140 themeOf CXCL8,expression
R13127 T16140 T16141 themeOf expression,inhibited
R13128 T16142 T16143 themeOf expression,affected
R13129 T16144 T16145 themeOf IL-6,release
R13130 T16145 T16146 themeOf release,inhibited
R13131 T16145 T16148 themeOf release,regulation
R13132 T16145 T16147 themeOf release,following
R13133 T16149 T16150 themeOf IL-6,expression
R13134 T16150 T16151 themeOf expression,increased
R13135 T16150 T16148 themeOf expression,regulation