PMC:2889865 / 10742-14966 JSON TXT

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pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T5145	0-11	JJ	denotes	Cooperative
T5146	12-21	NN	denotes	induction
T5147	22-24	IN	denotes	of
T5148	25-34	NN	denotes	cytokines
T5149	35-37	IN	denotes	by
T5150	38-42	NN	denotes	AP-1
T5151	43-46	CC	denotes	and
T5152	47-52	NN	denotes	NF-κB
T5153	53-55	TO	denotes	To
T5154	56-63	RB	denotes	further
T5155	64-76	VB	denotes	characterize
T5156	77-80	DT	denotes	the
T5157	81-92	NN	denotes	involvement
T5158	93-95	IN	denotes	of
T5159	96-101	NN	denotes	NF-κB
T5160	102-104	IN	denotes	in
T5161	105-113	NN	denotes	cytokine
T5162	114-124	NN	denotes	regulation
T5163	124-125	-COMMA-	denotes	,
T5164	126-128	PRP	denotes	we
T5165	129-136	VB	denotes	treated
T5166	137-142	NN	denotes	cells
T5167	143-147	IN	denotes	with
T5168	148-150	DT	denotes	an
T5169	151-156	NN	denotes	NF-κB
T5170	157-167	NN	denotes	activation
T5171	168-177	NN	denotes	inhibitor
T5172	178-179	-LRB-	denotes	(
T5173	179-182	NN	denotes	NAI
T5174	182-183	-RRB-	denotes	)
T5175	185-188	DT	denotes	The
T5176	189-196	NN	denotes	results
T5177	197-203	VB	denotes	showed
T5178	204-208	IN	denotes	that
T5179	209-212	NN	denotes	NAI
T5180	213-224	RB	denotes	selectively
T5181	225-239	VB	denotes	down-regulated
T5182	240-245	NN	denotes	NF-κB
T5183	246-256	NN	denotes	activation
T5184	257-258	-LRB-	denotes	(
T5185	258-265	NN	denotes	figures
T5186	266-268	NN	denotes	4a
T5187	269-272	CC	denotes	and
T5188	273-275	NN	denotes	4b
T5189	275-276	-RRB-	denotes	)
T5190	277-280	CC	denotes	and
T5191	281-284	VB	denotes	did
T5192	285-288	RB	denotes	not
T5193	289-294	VB	denotes	alter
T5194	295-299	NN	denotes	AP-1
T5195	300-308	NN	denotes	activity
T5196	309-310	-LRB-	denotes	(
T5197	310-317	NN	denotes	figures
T5198	318-320	NN	denotes	4c
T5199	321-324	CC	denotes	and
T5200	325-327	NN	denotes	4d
T5201	327-328	-RRB-	denotes	)
T5202	330-338	NN	denotes	Exposure
T5203	339-341	IN	denotes	of
T5204	342-348	NN	denotes	Jurkat
T5205	349-356	NN	denotes	T-cells
T5206	357-359	TO	denotes	to
T5207	360-363	NN	denotes	NAI
T5208	364-372	VB	denotes	resulted
T5209	373-375	IN	denotes	in
T5210	376-377	DT	denotes	a
T5211	378-384	JJ	denotes	modest
T5212	385-394	NN	denotes	reduction
T5213	395-397	IN	denotes	of
T5214	398-403	NN	denotes	CXCL8
T5215	404-413	VB	denotes	following
T5216	414-417	NN	denotes	PMA
T5217	418-426	NN	denotes	exposure
T5218	426-427	-COMMA-	denotes	,
T5219	428-433	IN	denotes	while
T5220	434-436	PRP	denotes	it
T5221	437-440	VB	denotes	did
T5222	441-444	RB	denotes	not
T5223	445-450	VB	denotes	alter
T5224	451-454	DT	denotes	the
T5225	455-460	NN	denotes	CXCL8
T5226	461-468	NN	denotes	release
T5227	469-478	VB	denotes	following
T5228	479-481	NN	denotes	HK
T5229	482-484	FW	denotes	E.
T5230	485-489	FW	denotes	coli
T5231	490-498	NN	denotes	exposure
T5232	499-500	-LRB-	denotes	(
T5233	500-506	NN	denotes	figure
T5234	507-509	NN	denotes	5a
T5235	509-510	-RRB-	denotes	)
T5236	512-515	NN	denotes	NAI
T5237	516-519	VB	denotes	did
T5238	520-523	RB	denotes	not
T5239	524-530	VB	denotes	affect
T5240	531-534	NN	denotes	TNF
T5241	535-545	NN	denotes	expression
T5242	546-547	-LRB-	denotes	(
T5243	547-553	NN	denotes	figure
T5244	554-556	NN	denotes	5b
T5245	556-557	-RRB-	denotes	)
T5246	558-568	VB	denotes	indicating
T5247	569-573	IN	denotes	that
T5248	574-579	NN	denotes	NF-κB
T5249	580-582	VB	denotes	is
T5250	583-586	RB	denotes	not
T5251	587-590	DT	denotes	the
T5252	591-595	JJ	denotes	main
T5253	596-605	NN	denotes	regulator
T5254	606-608	IN	denotes	of
T5255	609-614	NN	denotes	CXCL8
T5256	615-617	CC	denotes	or
T5257	618-621	NN	denotes	TNF
T5258	622-631	VB	denotes	following
T5259	632-638	CC	denotes	either
T5260	639-642	NN	denotes	PMA
T5261	643-645	CC	denotes	or
T5262	646-648	NN	denotes	HK
T5263	649-651	FW	denotes	E.
T5264	652-656	FW	denotes	coli
T5265	657-665	NN	denotes	exposure
T5266	666-668	IN	denotes	in
T5267	669-675	NN	denotes	Jurkat
T5268	676-683	NN	denotes	T-cells
T5269	685-687	IN	denotes	In
T5270	688-696	NN	denotes	contrast
T5271	696-697	-COMMA-	denotes	,
T5272	698-701	NN	denotes	NAI
T5273	702-710	VB	denotes	resulted
T5274	711-713	IN	denotes	in
T5275	714-715	DT	denotes	a
T5276	716-724	JJ	denotes	complete
T5277	725-735	NN	denotes	inhibition
T5278	736-738	IN	denotes	of
T5279	739-743	NN	denotes	IL-6
T5280	744-753	VB	denotes	following
T5281	754-757	NN	denotes	PMA
T5282	758-766	NN	denotes	exposure
T5283	767-770	CC	denotes	and
T5284	771-772	DT	denotes	a
T5285	773-775	CD	denotes	45
T5286	775-776	NN	denotes	%
T5287	777-787	NN	denotes	inhibition
T5288	788-797	VB	denotes	following
T5289	798-800	NN	denotes	HK
T5290	801-803	FW	denotes	E.
T5291	804-808	FW	denotes	coli
T5292	809-817	NN	denotes	exposure
T5293	818-819	-LRB-	denotes	(
T5294	819-825	NN	denotes	figure
T5295	826-828	NN	denotes	5c
T5296	828-829	-RRB-	denotes	)
T5297	829-830	-COMMA-	denotes	,
T5298	831-841	VB	denotes	suggesting
T5299	842-844	DT	denotes	an
T5300	845-856	NN	denotes	involvement
T5301	857-859	IN	denotes	of
T5302	860-865	NN	denotes	NF-κB
T5303	866-868	IN	denotes	in
T5304	869-873	NN	denotes	IL-6
T5305	874-884	NN	denotes	regulation
T5306	2183-2187	NN	denotes	Ca2+
T5307	2188-2191	VB	denotes	was
T5308	2192-2200	VB	denotes	observed
T5309	2201-2203	TO	denotes	to
T5310	2204-2212	VB	denotes	increase
T5311	2213-2217	NN	denotes	AP-1
T5312	2218-2226	NN	denotes	activity
T5313	2227-2228	-LRB-	denotes	(
T5314	2228-2234	NN	denotes	figure
T5315	2235-2237	NN	denotes	1c
T5316	2237-2238	-RRB-	denotes	)
T5317	2239-2242	CC	denotes	and
T5318	2243-2249	VB	denotes	reduce
T5319	2250-2255	NN	denotes	NF-κB
T5320	2256-2264	NN	denotes	activity
T5321	2265-2266	-LRB-	denotes	(
T5322	2266-2272	NN	denotes	figure
T5323	2273-2275	NN	denotes	2e
T5324	2275-2276	-RRB-	denotes	)
T5325	2276-2277	-COLON-	denotes	;
T5326	2278-2287	RB	denotes	therefore
T5327	2287-2288	-COMMA-	denotes	,
T5328	2289-2291	PRP	denotes	we
T5329	2292-2299	VB	denotes	exposed
T5330	2300-2307	NN	denotes	T-cells
T5331	2308-2310	TO	denotes	to
T5332	2311-2312	DT	denotes	a
T5333	2313-2316	NN	denotes	PKC
T5334	2317-2326	NN	denotes	inhibitor
T5335	2327-2335	RB	denotes	together
T5336	2336-2340	IN	denotes	with
T5337	2341-2344	NN	denotes	PMA
T5338	2345-2347	TO	denotes	to
T5339	2348-2357	VB	denotes	determine
T5340	2358-2361	PRP-DOLLAR-	denotes	its
T5341	2362-2368	NN	denotes	effect
T5342	2369-2371	IN	denotes	on
T5343	2372-2380	NN	denotes	cytokine
T5344	2381-2391	NN	denotes	expression
T5345	2393-2403	NN	denotes	Inhibition
T5346	2404-2406	IN	denotes	of
T5347	2407-2410	NN	denotes	PKC
T5348	2411-2418	VB	denotes	reduced
T5349	2419-2424	NN	denotes	CXCL8
T5350	2425-2432	NN	denotes	release
T5351	2433-2437	IN	denotes	from
T5352	2438-2439	CD	denotes	7
T5353	2440-2445	NN	denotes	ng/ml
T5354	2446-2448	TO	denotes	to
T5355	2449-2450	CD	denotes	3
T5356	2451-2456	NN	denotes	ng/ml
T5357	2457-2462	IN	denotes	while
T5358	2463-2465	PRP	denotes	it
T5359	2466-2469	VB	denotes	had
T5360	2470-2471	DT	denotes	a
T5361	2472-2478	JJ	denotes	modest
T5362	2479-2485	NN	denotes	effect
T5363	2486-2488	IN	denotes	on
T5364	2489-2493	NN	denotes	IL-6
T5365	2494-2497	CC	denotes	and
T5366	2498-2501	NN	denotes	TNF
T5367	2502-2503	-LRB-	denotes	(
T5368	2503-2509	NN	denotes	figure
T5369	2510-2514	NN	denotes	6a-c
T5370	2514-2515	-RRB-	denotes	)
T5371	2517-2521	DT	denotes	This
T5372	2522-2530	VB	denotes	prompted
T5373	2531-2533	PRP	denotes	us
T5374	2534-2536	TO	denotes	to
T5375	2537-2541	VB	denotes	test
T5376	2542-2545	DT	denotes	the
T5377	2546-2552	NN	denotes	effect
T5378	2553-2555	IN	denotes	of
T5379	2556-2559	NN	denotes	JNK
T5380	2560-2570	NN	denotes	inhibition
T5381	2571-2573	IN	denotes	on
T5382	2574-2585	JJ	denotes	PMA-induced
T5383	2586-2594	NN	denotes	cytokine
T5384	2595-2605	NN	denotes	expression
T5385	2607-2610	NN	denotes	JNK
T5386	2611-2613	VB	denotes	is
T5387	2614-2622	VB	denotes	involved
T5388	2623-2625	IN	denotes	in
T5389	2626-2629	DT	denotes	the
T5390	2630-2640	NN	denotes	regulation
T5391	2641-2643	IN	denotes	of
T5392	2644-2645	DT	denotes	a
T5393	2646-2655	NN	denotes	multitude
T5394	2656-2658	IN	denotes	of
T5395	2659-2668	JJ	denotes	different
T5396	2669-2682	NN	denotes	transcription
T5397	2683-2690	NN	denotes	factors
T5398	2690-2691	-COMMA-	denotes	,
T5399	2692-2701	VB	denotes	including
T5400	2702-2705	DT	denotes	the
T5401	2706-2721	NN	denotes	phosphorylation
T5402	2722-2725	CC	denotes	and
T5403	2726-2736	NN	denotes	activation
T5404	2737-2739	IN	denotes	of
T5405	2740-2745	NN	denotes	c-Jun
T5406	2745-2746	-COMMA-	denotes	,
T5407	2747-2752	NN	denotes	c-Fos
T5408	2753-2756	CC	denotes	and
T5409	2757-2760	NN	denotes	p53
T5410	2760-2761	-COMMA-	denotes	,
T5411	2762-2769	VB	denotes	leading
T5412	2770-2772	TO	denotes	to
T5413	2773-2781	JJ	denotes	cellular
T5414	2782-2791	NN	denotes	apoptosis
T5415	2792-2793	-LRB-	denotes	[
T5416	2793-2795	CD	denotes	26
T5417	2795-2796	-RRB-	denotes	]
T5418	2798-2808	NN	denotes	Inhibition
T5419	2809-2811	IN	denotes	of
T5420	2812-2815	DT	denotes	the
T5421	2816-2819	NN	denotes	JNK
T5422	2820-2828	NN	denotes	pathways
T5423	2829-2837	VB	denotes	resulted
T5424	2838-2840	IN	denotes	in
T5425	2841-2842	DT	denotes	a
T5426	2843-2858	NN	denotes	down-regulation
T5427	2859-2861	IN	denotes	of
T5428	2862-2866	CC	denotes	both
T5429	2867-2872	NN	denotes	CXCL8
T5430	2873-2876	CC	denotes	and
T5431	2877-2881	NN	denotes	IL-6
T5432	2881-2882	-COMMA-	denotes	,
T5433	2883-2888	IN	denotes	while
T5434	2889-2891	DT	denotes	no
T5435	2892-2897	JJ	denotes	clear
T5436	2898-2904	NN	denotes	effect
T5437	2905-2908	VB	denotes	was
T5438	2909-2917	VB	denotes	observed
T5439	2918-2920	IN	denotes	on
T5440	2921-2924	NN	denotes	TNF
T5441	2925-2935	NN	denotes	expression
T5442	2936-2937	-LRB-	denotes	(
T5443	2937-2943	NN	denotes	figure
T5444	2944-2948	NN	denotes	6a-c
T5445	2948-2949	-RRB-	denotes	)
T5446	2951-2959	NN	denotes	Analysis
T5447	2960-2962	IN	denotes	of
T5448	2963-2967	NN	denotes	mRNA
T5449	2968-2974	NN	denotes	levels
T5450	2975-2980	VB	denotes	using
T5451	2981-2988	NN	denotes	RT-qPCR
T5452	2989-2990	-LRB-	denotes	(
T5453	2990-2995	NN	denotes	table
T5454	2996-2997	CD	denotes	2
T5455	2997-2998	-RRB-	denotes	)
T5456	2999-3005	VB	denotes	showed
T5457	3006-3010	IN	denotes	that
T5458	3011-3014	NN	denotes	PMA
T5459	3015-3022	VB	denotes	induced
T5460	3023-3027	CC	denotes	both
T5461	3028-3032	NN	denotes	il-6
T5462	3033-3036	CC	denotes	and
T5463	3037-3042	NN	denotes	cxcl8
T5464	3043-3047	NN	denotes	mRNA
T5465	3048-3049	-LRB-	denotes	(
T5466	3049-3057	JJ	denotes	5.1-fold
T5467	3058-3061	CC	denotes	and
T5468	3062-3067	CD	denotes	111.8
T5469	3068-3072	RB	denotes	fold
T5470	3073-3085	RB	denotes	respectively
T5471	3085-3086	-RRB-	denotes	)
T5472	3088-3096	NN	denotes	Addition
T5473	3097-3099	IN	denotes	of
T5474	3100-3103	DT	denotes	the
T5475	3104-3109	NN	denotes	NF-κB
T5476	3110-3119	NN	denotes	inhibitor
T5477	3120-3123	NN	denotes	NAI
T5478	3124-3127	CC	denotes	and
T5479	3128-3131	DT	denotes	the
T5480	3132-3135	NN	denotes	JNK
T5481	3136-3145	NN	denotes	inhibitor
T5482	3146-3153	VB	denotes	reduced
T5483	3154-3157	DT	denotes	the
T5484	3158-3162	NN	denotes	il-6
T5485	3163-3173	NN	denotes	expression
T5486	3174-3179	IN	denotes	below
T5487	3180-3185	JJ	denotes	basal
T5488	3186-3192	NN	denotes	levels
T5489	3194-3196	IN	denotes	In
T5490	3197-3205	NN	denotes	contrast
T5491	3205-3206	-COMMA-	denotes	,
T5492	3207-3212	IN	denotes	while
T5493	3213-3216	DT	denotes	the
T5494	3217-3222	NN	denotes	cxcl8
T5495	3223-3229	NN	denotes	levels
T5496	3230-3234	VB	denotes	were
T5497	3235-3245	VB	denotes	suppressed
T5498	3246-3248	IN	denotes	by
T5499	3249-3252	DT	denotes	the
T5500	3253-3257	JJ	denotes	same
T5501	3258-3268	NN	denotes	treatments
T5502	3269-3272	DT	denotes	the
T5503	3273-3279	NN	denotes	levels
T5504	3280-3288	VB	denotes	remained
T5505	3289-3297	JJ	denotes	elevated
T5506	3298-3303	IN	denotes	above
T5507	3304-3309	JJ	denotes	basal
T5508	3310-3315	NN	denotes	level
T15991	896-906	NN	denotes	Inhibition
T15992	907-909	IN	denotes	of
T15993	910-915	NN	denotes	NF-κB
T15994	916-924	NN	denotes	activity
T15995	925-927	IN	denotes	by
T15996	928-931	NN	denotes	NAI
T15997	933-939	NN	denotes	Jurkat
T15998	940-947	NN	denotes	T-cells
T15999	948-952	VB	denotes	were
T16000	953-964	VB	denotes	transfected
T16001	965-969	IN	denotes	with
T16002	970-980	NN	denotes	luciferase
T16003	981-989	NN	denotes	reporter
T16004	990-998	NN	denotes	plasmids
T16005	999-1009	VB	denotes	containing
T16006	1010-1016	CC	denotes	either
T16007	1017-1022	NN	denotes	NF-κB
T16008	1023-1025	CC	denotes	or
T16009	1026-1030	NN	denotes	AP-1
T16010	1031-1041	JJ	denotes	cis-acting
T16011	1042-1050	NN	denotes	elements
T16012	1052-1055	DT	denotes	The
T16013	1056-1061	NN	denotes	cells
T16014	1062-1066	VB	denotes	were
T16015	1067-1076	VB	denotes	incubated
T16016	1077-1081	IN	denotes	with
T16017	1082-1087	NN	denotes	NF-κB
T16018	1088-1098	NN	denotes	activation
T16019	1099-1108	NN	denotes	inhibitor
T16020	1109-1110	-LRB-	denotes	(
T16021	1110-1113	NN	denotes	NAI
T16022	1113-1114	-RRB-	denotes	)
T16023	1115-1118	IN	denotes	for
T16024	1119-1120	CD	denotes	1
T16025	1121-1122	NN	denotes	h
T16026	1123-1131	VB	denotes	followed
T16027	1132-1134	IN	denotes	by
T16028	1135-1146	NN	denotes	stimulation
T16029	1147-1151	IN	denotes	with
T16030	1152-1155	NN	denotes	PMA
T16031	1156-1157	-LRB-	denotes	(
T16032	1157-1160	CD	denotes	162
T16033	1161-1163	NN	denotes	nM
T16034	1163-1164	-COMMA-	denotes	,
T16035	1165-1166	NN	denotes	A
T16036	1167-1170	CC	denotes	and
T16037	1171-1172	NN	denotes	C
T16038	1172-1173	-RRB-	denotes	)
T16039	1174-1176	CC	denotes	or
T16040	1177-1179	NN	denotes	HK
T16041	1180-1182	FW	denotes	E.
T16042	1183-1187	FW	denotes	coli
T16043	1188-1189	-LRB-	denotes	(
T16044	1189-1190	CD	denotes	5
T16045	1191-1192	NN	denotes	×
T16046	1193-1196	CD	denotes	107
T16047	1197-1203	NNP	denotes	CFU/ml
T16048	1203-1204	-COMMA-	denotes	,
T16049	1205-1206	NN	denotes	B
T16050	1207-1210	CC	denotes	and
T16051	1211-1212	NN	denotes	D
T16052	1212-1213	-RRB-	denotes	)
T16053	1214-1217	IN	denotes	for
T16054	1218-1220	CD	denotes	24
T16055	1221-1223	NN	denotes	h.
T16056	1224-1225	-LRB-	denotes	(
T16057	1225-1226	NN	denotes	A
T16058	1226-1227	-COMMA-	denotes	,
T16059	1228-1229	NN	denotes	B
T16060	1229-1230	-RRB-	denotes	)
T16061	1231-1236	NN	denotes	NF-κB
T16062	1236-1237	-COMMA-	denotes	,
T16063	1238-1241	CC	denotes	but
T16064	1242-1245	RB	denotes	not
T16065	1246-1247	-LRB-	denotes	(
T16066	1247-1248	NN	denotes	C
T16067	1248-1249	-COMMA-	denotes	,
T16068	1250-1251	NN	denotes	D
T16069	1251-1252	-RRB-	denotes	)
T16070	1253-1257	NN	denotes	AP-1
T16071	1258-1261	VB	denotes	was
T16072	1262-1271	VB	denotes	inhibited
T16073	1273-1284	JJ	denotes	Statistical
T16074	1285-1297	NN	denotes	significance
T16075	1298-1302	IN	denotes	from
T16076	1303-1306	DT	denotes	the
T16077	1307-1315	JJ	denotes	positive
T16078	1316-1323	NN	denotes	control
T16079	1324-1325	-LRB-	denotes	(
T16080	1325-1331	NN	denotes	PMA/HK
T16081	1332-1334	FW	denotes	E.
T16082	1335-1339	FW	denotes	coli
T16083	1339-1340	-RRB-	denotes	)
T16084	1341-1344	VB	denotes	was
T16085	1345-1355	VB	denotes	determined
T16086	1356-1361	VB	denotes	using
T16087	1362-1369	NN	denotes	Student
T16088	1369-1371	POS	denotes	's
T16089	1372-1379	NN	denotes	t-test.
T16090	1380-1381	-LRB-	denotes	(
T16091	1381-1382	NN	denotes	n
T16092	1383-1384	SYM	denotes	=
T16093	1385-1386	CD	denotes	4
T16094	1386-1387	-RRB-	denotes	)
T16095	1389-1397	NN	denotes	Controls
T16096	1398-1402	VB	denotes	were
T16097	1403-1406	VB	denotes	set
T16098	1407-1409	TO	denotes	to
T16099	1410-1411	CD	denotes	1
T16538	3327-3338	NN	denotes	Involvement
T16539	3339-3341	IN	denotes	of
T16540	3342-3345	NN	denotes	PKC
T16541	3346-3349	CC	denotes	and
T16542	3350-3353	NN	denotes	JNK
T16543	3354-3356	IN	denotes	in
T16544	3357-3365	NN	denotes	cytokine
T16545	3366-3376	NN	denotes	expression
T16546	3378-3384	NN	denotes	Jurkat
T16547	3385-3392	NN	denotes	T-cells
T16548	3393-3397	VB	denotes	were
T16549	3398-3407	VB	denotes	incubated
T16550	3408-3412	IN	denotes	with
T16551	3413-3417	NN	denotes	PKC-
T16552	3418-3421	CC	denotes	and
T16553	3422-3425	NN	denotes	JNK
T16554	3426-3436	NN	denotes	inhibitors
T16555	3437-3440	IN	denotes	for
T16556	3441-3442	CD	denotes	1
T16557	3443-3444	NN	denotes	h
T16558	3445-3453	VB	denotes	followed
T16559	3454-3456	IN	denotes	by
T16560	3457-3468	NN	denotes	stimulation
T16561	3469-3473	IN	denotes	with
T16562	3474-3477	NN	denotes	PMA
T16563	3478-3479	-LRB-	denotes	(
T16564	3479-3482	CD	denotes	162
T16565	3483-3485	NN	denotes	nM
T16566	3485-3486	-RRB-	denotes	)
T16567	3487-3490	IN	denotes	for
T16568	3491-3493	CD	denotes	24
T16569	3494-3496	NN	denotes	h.
T16570	3497-3498	-LRB-	denotes	(
T16571	3498-3499	NN	denotes	A
T16572	3499-3500	-RRB-	denotes	)
T16573	3501-3506	NN	denotes	CXCL8
T16574	3507-3517	NN	denotes	expression
T16575	3518-3521	VB	denotes	was
T16576	3522-3531	VB	denotes	inhibited
T16577	3532-3534	IN	denotes	in
T16578	3535-3536	DT	denotes	a
T16579	3537-3551	JJ	denotes	dose-dependent
T16580	3552-3558	NN	denotes	manner
T16581	3559-3561	IN	denotes	by
T16582	3562-3566	CC	denotes	both
T16583	3567-3578	NN	denotes	inhibitors.
T16584	3579-3580	-LRB-	denotes	(
T16585	3580-3581	NN	denotes	B
T16586	3581-3582	-RRB-	denotes	)
T16587	3583-3588	NN	denotes	JNK-I
T16588	3589-3597	VB	denotes	revealed
T16589	3598-3599	DT	denotes	a
T16590	3600-3608	JJ	denotes	stronger
T16591	3609-3619	JJ	denotes	inhibitory
T16592	3620-3626	NN	denotes	effect
T16593	3627-3629	IN	denotes	on
T16594	3630-3634	NN	denotes	IL-6
T16595	3635-3645	NN	denotes	expression
T16596	3646-3650	IN	denotes	than
T16597	3651-3654	DT	denotes	the
T16598	3655-3661	NN	denotes	PKC-I.
T16599	3662-3663	-LRB-	denotes	(
T16600	3663-3664	NN	denotes	C
T16601	3664-3665	-RRB-	denotes	)
T16602	3666-3669	NN	denotes	TNF
T16603	3670-3680	NN	denotes	expression
T16604	3681-3684	VB	denotes	was
T16605	3685-3688	RB	denotes	not
T16606	3689-3697	VB	denotes	affected
T16607	3698-3700	IN	denotes	by
T16608	3701-3707	DT	denotes	either
T16609	3708-3717	NN	denotes	inhibitor
T16610	3719-3730	JJ	denotes	Statistical
T16611	3731-3743	NN	denotes	significance
T16612	3744-3748	IN	denotes	from
T16613	3749-3752	DT	denotes	the
T16614	3753-3761	JJ	denotes	positive
T16615	3762-3769	NN	denotes	control
T16616	3770-3771	-LRB-	denotes	(
T16617	3771-3774	NN	denotes	PMA
T16618	3774-3775	-RRB-	denotes	)
T16619	3776-3779	VB	denotes	was
T16620	3780-3790	VB	denotes	determined
T16621	3791-3796	VB	denotes	using
T16622	3797-3804	NN	denotes	Student
T16623	3804-3806	POS	denotes	's
T16624	3807-3814	NN	denotes	t-test.
T16625	3815-3816	-LRB-	denotes	(
T16626	3816-3817	NN	denotes	n
T16627	3818-3819	SYM	denotes	=
T16628	3820-3821	CD	denotes	3
T16629	3821-3822	-RRB-	denotes	)
T17075	3833-3839	NN	denotes	Jurkat
T17076	3840-3847	NN	denotes	T-cells
T17077	3848-3852	VB	denotes	were
T17078	3853-3860	VB	denotes	treated
T17079	3861-3865	IN	denotes	with
T17080	3866-3868	CD	denotes	10
T17081	3869-3871	NN	denotes	nM
T17082	3872-3875	NN	denotes	NAI
T17083	3875-3876	-COMMA-	denotes	,
T17084	3877-3879	CD	denotes	10
T17085	3880-3882	NN	denotes	μM
T17086	3883-3888	NN	denotes	JNK-I
T17087	3889-3893	NN	denotes	or10
T17088	3894-3896	NN	denotes	nM
T17089	3897-3902	NN	denotes	PKC-I
T17090	3903-3906	IN	denotes	for
T17091	3907-3908	CD	denotes	2
T17092	3909-3910	NN	denotes	h
T17093	3911-3919	VB	denotes	followed
T17094	3920-3922	IN	denotes	by
T17095	3923-3932	NN	denotes	induction
T17096	3933-3937	IN	denotes	with
T17097	3938-3941	CD	denotes	162
T17098	3942-3944	NN	denotes	nM
T17099	3945-3948	NN	denotes	PMA
T17100	3949-3952	IN	denotes	for
T17101	3953-3955	CD	denotes	24
T17102	3956-3957	NN	denotes	h
R4194	T5146	T5145	arg1Of	induction,Cooperative
R4195	T5146	T5147	arg1Of	induction,of
R4196	T5146	T5149	arg1Of	induction,by
R4197	T5148	T5147	arg2Of	cytokines,of
R4198	T5150	T5151	arg1Of	AP-1,and
R4199	T5151	T5149	arg2Of	and,by
R4200	T5152	T5151	arg2Of	NF-κB,and
R4201	T5155	T5153	arg1Of	characterize,To
R4202	T5155	T5154	arg1Of	characterize,further
R4203	T5157	T5155	arg2Of	involvement,characterize
R4204	T5157	T5156	arg1Of	involvement,the
R4205	T5157	T5158	arg1Of	involvement,of
R4206	T5157	T5160	arg1Of	involvement,in
R4207	T5159	T5158	arg2Of	NF-κB,of
R4208	T5162	T5160	arg2Of	regulation,in
R4209	T5162	T5161	arg1Of	regulation,cytokine
R4210	T5164	T5155	arg1Of	we,characterize
R4211	T5164	T5165	arg1Of	we,treated
R4212	T5165	T5153	modOf	treated,To
R4213	T5165	T5163	arg1Of	treated,","
R4214	T5165	T5167	arg1Of	treated,with
R4215	T5166	T5165	arg2Of	cells,treated
R4216	T5171	T5167	arg2Of	inhibitor,with
R4217	T5171	T5168	arg1Of	inhibitor,an
R4218	T5171	T5169	arg1Of	inhibitor,NF-κB
R4219	T5171	T5170	arg1Of	inhibitor,activation
R4220	T5171	T5172	arg1Of	inhibitor,(
R4221	T5173	T5172	arg2Of	NAI,(
R4222	T5174	T5172	arg3Of	),(
R4223	T5176	T5175	arg1Of	results,The
R4224	T5176	T5177	arg1Of	results,showed
R4225	T5179	T5181	arg1Of	NAI,down-regulated
R4226	T5179	T5191	arg1Of	NAI,did
R4227	T5179	T5193	arg1Of	NAI,alter
R4228	T5181	T5190	arg1Of	down-regulated,and
R4229	T5183	T5181	arg2Of	activation,down-regulated
R4230	T5183	T5182	arg1Of	activation,NF-κB
R4231	T5183	T5184	arg1Of	activation,(
R4232	T5186	T5187	arg1Of	4a,and
R4233	T5187	T5184	arg2Of	and,(
R4234	T5187	T5185	arg1Of	and,figures
R4235	T5188	T5187	arg2Of	4b,and
R4236	T5189	T5184	arg3Of	),(
R4237	T5190	T5177	arg2Of	and,showed
R4238	T5190	T5178	arg1Of	and,that
R4239	T5190	T5180	arg1Of	and,selectively
R4240	T5193	T5190	arg2Of	alter,and
R4241	T5193	T5191	arg2Of	alter,did
R4242	T5193	T5192	arg1Of	alter,not
R4243	T5195	T5193	arg2Of	activity,alter
R4244	T5195	T5194	arg1Of	activity,AP-1
R4245	T5195	T5196	arg1Of	activity,(
R4246	T5198	T5199	arg1Of	4c,and
R4247	T5199	T5196	arg2Of	and,(
R4248	T5199	T5197	arg1Of	and,figures
R4249	T5200	T5199	arg2Of	4d,and
R4250	T5201	T5196	arg3Of	),(
R4251	T5202	T5203	arg1Of	Exposure,of
R4252	T5202	T5206	arg1Of	Exposure,to
R4253	T5202	T5208	arg1Of	Exposure,resulted
R4254	T5205	T5203	arg2Of	T-cells,of
R4255	T5205	T5204	arg1Of	T-cells,Jurkat
R4256	T5207	T5206	arg2Of	NAI,to
R4257	T5208	T5209	arg1Of	resulted,in
R4258	T5208	T5218	arg1Of	resulted,","
R4259	T5208	T5219	arg1Of	resulted,while
R4260	T5212	T5209	arg2Of	reduction,in
R4261	T5212	T5210	arg1Of	reduction,a
R4262	T5212	T5211	arg1Of	reduction,modest
R4263	T5212	T5213	arg1Of	reduction,of
R4264	T5212	T5215	arg1Of	reduction,following
R4265	T5214	T5213	arg2Of	CXCL8,of
R4266	T5217	T5215	arg2Of	exposure,following
R4267	T5217	T5216	arg1Of	exposure,PMA
R4268	T5220	T5221	arg1Of	it,did
R4269	T5220	T5223	arg1Of	it,alter
R4270	T5223	T5219	arg2Of	alter,while
R4271	T5223	T5221	arg2Of	alter,did
R4272	T5223	T5222	arg1Of	alter,not
R4273	T5226	T5223	arg2Of	release,alter
R4274	T5226	T5224	arg1Of	release,the
R4275	T5226	T5225	arg1Of	release,CXCL8
R4276	T5226	T5227	arg1Of	release,following
R4277	T5231	T5227	arg2Of	exposure,following
R4278	T5231	T5228	arg1Of	exposure,HK
R4279	T5231	T5229	arg1Of	exposure,E.
R4280	T5231	T5230	arg1Of	exposure,coli
R4281	T5231	T5232	arg1Of	exposure,(
R4282	T5234	T5232	arg2Of	5a,(
R4283	T5234	T5233	arg1Of	5a,figure
R4284	T5235	T5232	arg3Of	),(
R4285	T5236	T5237	arg1Of	NAI,did
R4286	T5236	T5239	arg1Of	NAI,affect
R4287	T5239	T5237	arg2Of	affect,did
R4288	T5239	T5238	arg1Of	affect,not
R4289	T5239	T5246	modOf	affect,indicating
R4290	T5241	T5239	arg2Of	expression,affect
R4291	T5241	T5240	arg1Of	expression,TNF
R4292	T5241	T5242	arg1Of	expression,(
R4293	T5244	T5242	arg2Of	5b,(
R4294	T5244	T5243	arg1Of	5b,figure
R4295	T5245	T5242	arg3Of	),(
R4296	T5248	T5249	arg1Of	NF-κB,is
R4297	T5249	T5246	arg2Of	is,indicating
R4298	T5249	T5247	arg1Of	is,that
R4299	T5249	T5250	arg1Of	is,not
R4300	T5253	T5249	arg2Of	regulator,is
R4301	T5253	T5251	arg1Of	regulator,the
R4302	T5253	T5252	arg1Of	regulator,main
R4303	T5253	T5254	arg1Of	regulator,of
R4304	T5253	T5258	arg1Of	regulator,following
R4305	T5255	T5256	arg1Of	CXCL8,or
R4306	T5256	T5254	arg2Of	or,of
R4307	T5257	T5256	arg2Of	TNF,or
R4308	T5260	T5261	arg1Of	PMA,or
R4309	T5261	T5258	arg2Of	or,following
R4310	T5261	T5259	arg1Of	or,either
R4311	T5261	T5266	arg1Of	or,in
R4312	T5265	T5261	arg2Of	exposure,or
R4313	T5265	T5262	arg1Of	exposure,HK
R4314	T5265	T5263	arg1Of	exposure,E.
R4315	T5265	T5264	arg1Of	exposure,coli
R4316	T5268	T5266	arg2Of	T-cells,in
R4317	T5268	T5267	arg1Of	T-cells,Jurkat
R4318	T5270	T5269	arg2Of	contrast,In
R4319	T5272	T5273	arg1Of	NAI,resulted
R4320	T5273	T5269	arg1Of	resulted,In
R4321	T5273	T5271	arg1Of	resulted,","
R4322	T5273	T5274	arg1Of	resulted,in
R4323	T5273	T5297	arg1Of	resulted,","
R4324	T5273	T5298	modOf	resulted,suggesting
R4325	T5277	T5274	arg2Of	inhibition,in
R4326	T5277	T5275	arg1Of	inhibition,a
R4327	T5277	T5276	arg1Of	inhibition,complete
R4328	T5277	T5278	arg1Of	inhibition,of
R4329	T5277	T5280	arg1Of	inhibition,following
R4330	T5279	T5278	arg2Of	IL-6,of
R4331	T5282	T5281	arg1Of	exposure,PMA
R4332	T5282	T5283	arg1Of	exposure,and
R4333	T5283	T5280	arg2Of	and,following
R4334	T5285	T5286	arg1Of	45,%
R4335	T5287	T5283	arg2Of	inhibition,and
R4336	T5287	T5284	arg1Of	inhibition,a
R4337	T5287	T5285	arg1Of	inhibition,45
R4338	T5287	T5288	arg1Of	inhibition,following
R4339	T5292	T5288	arg2Of	exposure,following
R4340	T5292	T5289	arg1Of	exposure,HK
R4341	T5292	T5290	arg1Of	exposure,E.
R4342	T5292	T5291	arg1Of	exposure,coli
R4343	T5292	T5293	arg1Of	exposure,(
R4344	T5295	T5293	arg2Of	5c,(
R4345	T5295	T5294	arg1Of	5c,figure
R4346	T5296	T5293	arg3Of	),(
R4347	T5300	T5298	arg2Of	involvement,suggesting
R4348	T5300	T5299	arg1Of	involvement,an
R4349	T5300	T5301	arg1Of	involvement,of
R4350	T5300	T5303	arg1Of	involvement,in
R4351	T5302	T5301	arg2Of	NF-κB,of
R4352	T5305	T5303	arg2Of	regulation,in
R4353	T5305	T5304	arg1Of	regulation,IL-6
R4354	T5306	T5307	arg1Of	Ca2+,was
R4355	T5306	T5308	arg2Of	Ca2+,observed
R4356	T5306	T5310	arg1Of	Ca2+,increase
R4357	T5306	T5318	arg1Of	Ca2+,reduce
R4358	T5308	T5307	arg2Of	observed,was
R4359	T5308	T5325	arg1Of	observed,;
R4360	T5310	T5317	arg1Of	increase,and
R4361	T5312	T5310	arg2Of	activity,increase
R4362	T5312	T5311	arg1Of	activity,AP-1
R4363	T5312	T5313	arg1Of	activity,(
R4364	T5315	T5313	arg2Of	1c,(
R4365	T5315	T5314	arg1Of	1c,figure
R4366	T5316	T5313	arg3Of	),(
R4367	T5317	T5308	arg3Of	and,observed
R4368	T5317	T5309	arg1Of	and,to
R4369	T5318	T5317	arg2Of	reduce,and
R4370	T5320	T5318	arg2Of	activity,reduce
R4371	T5320	T5319	arg1Of	activity,NF-κB
R4372	T5320	T5321	arg1Of	activity,(
R4373	T5323	T5321	arg2Of	2e,(
R4374	T5323	T5322	arg1Of	2e,figure
R4375	T5324	T5321	arg3Of	),(
R4376	T5328	T5329	arg1Of	we,exposed
R4377	T5328	T5339	arg1Of	we,determine
R4378	T5329	T5325	arg2Of	exposed,;
R4379	T5329	T5326	arg1Of	exposed,therefore
R4380	T5329	T5327	arg1Of	exposed,","
R4381	T5329	T5331	arg1Of	exposed,to
R4382	T5329	T5335	arg1Of	exposed,together
R4383	T5329	T5338	modOf	exposed,to
R4384	T5330	T5329	arg2Of	T-cells,exposed
R4385	T5334	T5331	arg2Of	inhibitor,to
R4386	T5334	T5332	arg1Of	inhibitor,a
R4387	T5334	T5333	arg1Of	inhibitor,PKC
R4388	T5335	T5336	arg1Of	together,with
R4389	T5337	T5336	arg2Of	PMA,with
R4390	T5339	T5338	arg1Of	determine,to
R4391	T5341	T5339	arg2Of	effect,determine
R4392	T5341	T5340	arg1Of	effect,its
R4393	T5341	T5342	arg1Of	effect,on
R4394	T5344	T5342	arg2Of	expression,on
R4395	T5344	T5343	arg1Of	expression,cytokine
R4396	T5345	T5346	arg1Of	Inhibition,of
R4397	T5345	T5348	arg1Of	Inhibition,reduced
R4398	T5347	T5346	arg2Of	PKC,of
R4399	T5348	T5354	arg1Of	reduced,to
R4400	T5348	T5357	arg1Of	reduced,while
R4401	T5350	T5348	arg2Of	release,reduced
R4402	T5350	T5349	arg1Of	release,CXCL8
R4403	T5350	T5351	arg1Of	release,from
R4404	T5353	T5351	arg2Of	ng/ml,from
R4405	T5353	T5352	arg1Of	ng/ml,7
R4406	T5356	T5354	arg2Of	ng/ml,to
R4407	T5356	T5355	arg1Of	ng/ml,3
R4408	T5358	T5359	arg1Of	it,had
R4409	T5359	T5357	arg2Of	had,while
R4410	T5359	T5363	arg1Of	had,on
R4411	T5362	T5359	arg2Of	effect,had
R4412	T5362	T5360	arg1Of	effect,a
R4413	T5362	T5361	arg1Of	effect,modest
R4414	T5364	T5365	arg1Of	IL-6,and
R4415	T5365	T5363	arg2Of	and,on
R4416	T5365	T5367	arg1Of	and,(
R4417	T5366	T5365	arg2Of	TNF,and
R4418	T5369	T5367	arg2Of	6a-c,(
R4419	T5369	T5368	arg1Of	6a-c,figure
R4420	T5370	T5367	arg3Of	),(
R4421	T5371	T5372	arg1Of	This,prompted
R4422	T5373	T5372	arg2Of	us,prompted
R4423	T5373	T5375	arg1Of	us,test
R4424	T5375	T5372	arg3Of	test,prompted
R4425	T5375	T5374	arg1Of	test,to
R4426	T5377	T5375	arg2Of	effect,test
R4427	T5377	T5376	arg1Of	effect,the
R4428	T5377	T5378	arg1Of	effect,of
R4429	T5377	T5381	arg1Of	effect,on
R4430	T5380	T5378	arg2Of	inhibition,of
R4431	T5380	T5379	arg1Of	inhibition,JNK
R4432	T5384	T5381	arg2Of	expression,on
R4433	T5384	T5382	arg1Of	expression,PMA-induced
R4434	T5384	T5383	arg1Of	expression,cytokine
R4435	T5385	T5386	arg1Of	JNK,is
R4436	T5385	T5387	arg2Of	JNK,involved
R4437	T5387	T5386	arg2Of	involved,is
R4438	T5387	T5388	arg1Of	involved,in
R4439	T5387	T5410	arg1Of	involved,","
R4440	T5387	T5411	modOf	involved,leading
R4441	T5390	T5388	arg2Of	regulation,in
R4442	T5390	T5389	arg1Of	regulation,the
R4443	T5390	T5391	arg1Of	regulation,of
R4444	T5393	T5391	arg2Of	multitude,of
R4445	T5393	T5392	arg1Of	multitude,a
R4446	T5393	T5394	arg1Of	multitude,of
R4447	T5397	T5395	arg1Of	factors,different
R4448	T5397	T5396	arg1Of	factors,transcription
R4449	T5397	T5398	arg1Of	factors,","
R4450	T5397	T5399	arg1Of	factors,including
R4451	T5397	T5406	arg1Of	factors,","
R4452	T5401	T5402	arg1Of	phosphorylation,and
R4453	T5402	T5399	arg2Of	and,including
R4454	T5402	T5400	arg1Of	and,the
R4455	T5402	T5404	arg1Of	and,of
R4456	T5403	T5402	arg2Of	activation,and
R4457	T5405	T5404	arg2Of	c-Jun,of
R4458	T5406	T5394	arg2Of	",",of
R4459	T5407	T5408	arg1Of	c-Fos,and
R4460	T5408	T5406	arg2Of	and,","
R4461	T5409	T5408	arg2Of	p53,and
R4462	T5411	T5412	arg1Of	leading,to
R4463	T5414	T5412	arg2Of	apoptosis,to
R4464	T5414	T5413	arg1Of	apoptosis,cellular
R4465	T5414	T5415	arg1Of	apoptosis,[
R4466	T5416	T5415	arg2Of	26,[
R4467	T5417	T5415	arg3Of	],[
R4468	T5418	T5419	arg1Of	Inhibition,of
R4469	T5418	T5423	arg1Of	Inhibition,resulted
R4470	T5422	T5419	arg2Of	pathways,of
R4471	T5422	T5420	arg1Of	pathways,the
R4472	T5422	T5421	arg1Of	pathways,JNK
R4473	T5423	T5424	arg1Of	resulted,in
R4474	T5423	T5432	arg1Of	resulted,","
R4475	T5426	T5424	arg2Of	down-regulation,in
R4476	T5426	T5425	arg1Of	down-regulation,a
R4477	T5426	T5427	arg1Of	down-regulation,of
R4478	T5429	T5430	arg1Of	CXCL8,and
R4479	T5430	T5427	arg2Of	and,of
R4480	T5430	T5428	arg1Of	and,both
R4481	T5431	T5430	arg2Of	IL-6,and
R4482	T5433	T5423	arg2Of	while,resulted
R4483	T5436	T5434	arg1Of	effect,no
R4484	T5436	T5435	arg1Of	effect,clear
R4485	T5436	T5437	arg1Of	effect,was
R4486	T5436	T5438	arg2Of	effect,observed
R4487	T5438	T5433	arg2Of	observed,while
R4488	T5438	T5437	arg2Of	observed,was
R4489	T5438	T5439	arg1Of	observed,on
R4490	T5441	T5439	arg2Of	expression,on
R4491	T5441	T5440	arg1Of	expression,TNF
R4492	T5441	T5442	arg1Of	expression,(
R4493	T5444	T5442	arg2Of	6a-c,(
R4494	T5444	T5443	arg1Of	6a-c,figure
R4495	T5445	T5442	arg3Of	),(
R4496	T5446	T5447	arg1Of	Analysis,of
R4497	T5446	T5456	arg1Of	Analysis,showed
R4498	T5449	T5447	arg2Of	levels,of
R4499	T5449	T5448	arg1Of	levels,mRNA
R4500	T5449	T5450	arg1Of	levels,using
R4501	T5451	T5450	arg2Of	RT-qPCR,using
R4502	T5451	T5452	arg1Of	RT-qPCR,(
R4503	T5453	T5452	arg2Of	table,(
R4504	T5453	T5454	arg1Of	table,2
R4505	T5455	T5452	arg3Of	),(
R4506	T5458	T5459	arg1Of	PMA,induced
R4507	T5459	T5456	arg2Of	induced,showed
R4508	T5459	T5457	arg1Of	induced,that
R4509	T5461	T5462	arg1Of	il-6,and
R4510	T5463	T5462	arg2Of	cxcl8,and
R4511	T5464	T5459	arg2Of	mRNA,induced
R4512	T5464	T5460	arg1Of	mRNA,both
R4513	T5464	T5461	arg1Of	mRNA,il-6
R4514	T5464	T5463	arg1Of	mRNA,cxcl8
R4515	T5464	T5465	arg1Of	mRNA,(
R4516	T5466	T5467	arg1Of	5.1-fold,and
R4517	T5467	T5465	arg2Of	and,(
R4518	T5467	T5470	arg1Of	and,respectively
R4519	T5468	T5467	arg2Of	111.8,and
R4520	T5470	T5469	arg1Of	respectively,fold
R4521	T5471	T5465	arg3Of	),(
R4522	T5472	T5473	arg1Of	Addition,of
R4523	T5472	T5482	arg1Of	Addition,reduced
R4524	T5477	T5474	arg1Of	NAI,the
R4525	T5477	T5475	arg1Of	NAI,NF-κB
R4526	T5477	T5476	arg1Of	NAI,inhibitor
R4527	T5477	T5478	arg1Of	NAI,and
R4528	T5478	T5473	arg2Of	and,of
R4529	T5481	T5478	arg2Of	inhibitor,and
R4530	T5481	T5479	arg1Of	inhibitor,the
R4531	T5481	T5480	arg1Of	inhibitor,JNK
R4532	T5485	T5482	arg2Of	expression,reduced
R4533	T5485	T5483	arg1Of	expression,the
R4534	T5485	T5484	arg1Of	expression,il-6
R4535	T5485	T5486	arg1Of	expression,below
R4536	T5488	T5486	arg2Of	levels,below
R4537	T5488	T5487	arg1Of	levels,basal
R4538	T5490	T5489	arg2Of	contrast,In
R4539	T5495	T5493	arg1Of	levels,the
R4540	T5495	T5494	arg1Of	levels,cxcl8
R4541	T5495	T5496	arg1Of	levels,were
R4542	T5495	T5497	arg2Of	levels,suppressed
R4543	T5497	T5492	arg2Of	suppressed,while
R4544	T5497	T5496	arg2Of	suppressed,were
R4545	T5501	T5497	arg1Of	treatments,suppressed
R4546	T5501	T5498	arg2Of	treatments,by
R4547	T5501	T5499	arg1Of	treatments,the
R4548	T5501	T5500	arg1Of	treatments,same
R4549	T5503	T5502	arg1Of	levels,the
R4550	T5503	T5504	arg1Of	levels,remained
R4551	T5503	T5505	arg1Of	levels,elevated
R4552	T5504	T5489	arg1Of	remained,In
R4553	T5504	T5491	arg1Of	remained,","
R4554	T5504	T5492	arg1Of	remained,while
R4555	T5504	T5506	arg1Of	remained,above
R4556	T5505	T5504	arg2Of	elevated,remained
R4557	T5508	T5506	arg2Of	level,above
R4558	T5508	T5507	arg1Of	level,basal
R13004	T15991	T15992	arg1Of	Inhibition,of
R13005	T15991	T15995	arg1Of	Inhibition,by
R13006	T15994	T15992	arg2Of	activity,of
R13007	T15994	T15993	arg1Of	activity,NF-κB
R13008	T15996	T15995	arg2Of	NAI,by
R13009	T15998	T15997	arg1Of	T-cells,Jurkat
R13010	T15998	T15999	arg1Of	T-cells,were
R13011	T15998	T16000	arg2Of	T-cells,transfected
R13012	T16000	T15999	arg2Of	transfected,were
R13013	T16000	T16001	arg1Of	transfected,with
R13014	T16004	T16001	arg2Of	plasmids,with
R13015	T16004	T16002	arg1Of	plasmids,luciferase
R13016	T16004	T16003	arg1Of	plasmids,reporter
R13017	T16004	T16005	arg1Of	plasmids,containing
R13018	T16007	T16008	arg1Of	NF-κB,or
R13019	T16009	T16008	arg2Of	AP-1,or
R13020	T16011	T16005	arg2Of	elements,containing
R13021	T16011	T16006	arg1Of	elements,either
R13022	T16011	T16007	arg1Of	elements,NF-κB
R13023	T16011	T16009	arg1Of	elements,AP-1
R13024	T16011	T16010	arg1Of	elements,cis-acting
R13025	T16013	T16012	arg1Of	cells,The
R13026	T16013	T16014	arg1Of	cells,were
R13027	T16013	T16015	arg2Of	cells,incubated
R13028	T16015	T16014	arg2Of	incubated,were
R13029	T16015	T16016	arg1Of	incubated,with
R13030	T16015	T16026	modOf	incubated,followed
R13031	T16015	T16063	arg1Of	incubated,but
R13032	T16019	T16016	arg2Of	inhibitor,with
R13033	T16019	T16017	arg1Of	inhibitor,NF-κB
R13034	T16019	T16018	arg1Of	inhibitor,activation
R13035	T16019	T16020	arg1Of	inhibitor,(
R13036	T16019	T16023	arg1Of	inhibitor,for
R13037	T16021	T16020	arg2Of	NAI,(
R13038	T16022	T16020	arg3Of	),(
R13039	T16025	T16023	arg2Of	h,for
R13040	T16025	T16024	arg1Of	h,1
R13041	T16028	T16026	arg1Of	stimulation,followed
R13042	T16028	T16027	arg2Of	stimulation,by
R13043	T16028	T16029	arg1Of	stimulation,with
R13044	T16030	T16031	arg1Of	PMA,(
R13045	T16030	T16039	arg1Of	PMA,or
R13046	T16033	T16032	arg1Of	nM,162
R13047	T16033	T16034	arg1Of	nM,","
R13048	T16034	T16036	arg1Of	",",and
R13049	T16035	T16034	arg2Of	A,","
R13050	T16036	T16031	arg2Of	and,(
R13051	T16037	T16036	arg2Of	C,and
R13052	T16038	T16031	arg3Of	),(
R13053	T16039	T16029	arg2Of	or,with
R13054	T16042	T16040	arg1Of	coli,HK
R13055	T16042	T16041	arg1Of	coli,E.
R13056	T16042	T16043	arg1Of	coli,(
R13057	T16042	T16053	arg1Of	coli,for
R13058	T16042	T16056	arg1Of	coli,(
R13059	T16047	T16048	arg1Of	CFU/ml,","
R13060	T16048	T16050	arg1Of	",",and
R13061	T16049	T16048	arg2Of	B,","
R13062	T16050	T16043	arg2Of	and,(
R13063	T16050	T16044	arg1Of	and,5
R13064	T16050	T16045	arg1Of	and,×
R13065	T16050	T16046	arg1Of	and,107
R13066	T16051	T16050	arg2Of	D,and
R13067	T16052	T16043	arg3Of	),(
R13068	T16055	T16053	arg2Of	h.,for
R13069	T16055	T16054	arg1Of	h.,24
R13070	T16057	T16056	arg2Of	A,(
R13071	T16057	T16058	arg1Of	A,","
R13072	T16059	T16058	arg2Of	B,","
R13073	T16060	T16056	arg3Of	),(
R13074	T16061	T16039	arg2Of	NF-κB,or
R13075	T16061	T16042	arg1Of	NF-κB,coli
R13076	T16063	T16062	arg1Of	but,","
R13077	T16063	T16064	arg1Of	but,not
R13078	T16066	T16065	arg2Of	C,(
R13079	T16066	T16067	arg1Of	C,","
R13080	T16068	T16067	arg2Of	D,","
R13081	T16069	T16065	arg3Of	),(
R13082	T16070	T16065	arg1Of	AP-1,(
R13083	T16070	T16071	arg1Of	AP-1,was
R13084	T16070	T16072	arg2Of	AP-1,inhibited
R13085	T16072	T16063	arg2Of	inhibited,but
R13086	T16072	T16071	arg2Of	inhibited,was
R13087	T16074	T16073	arg1Of	significance,Statistical
R13088	T16074	T16075	arg1Of	significance,from
R13089	T16074	T16084	arg1Of	significance,was
R13090	T16074	T16085	arg2Of	significance,determined
R13091	T16078	T16075	arg2Of	control,from
R13092	T16078	T16076	arg1Of	control,the
R13093	T16078	T16077	arg1Of	control,positive
R13094	T16078	T16079	arg1Of	control,(
R13095	T16082	T16079	arg2Of	coli,(
R13096	T16082	T16080	arg1Of	coli,PMA/HK
R13097	T16082	T16081	arg1Of	coli,E.
R13098	T16083	T16079	arg3Of	),(
R13099	T16085	T16084	arg2Of	determined,was
R13100	T16086	T16085	arg3Of	using,determined
R13101	T16087	T16088	arg2Of	Student,'s
R13102	T16089	T16086	arg2Of	t-test.,using
R13103	T16089	T16088	arg1Of	t-test.,'s
R13104	T16089	T16090	arg1Of	t-test.,(
R13105	T16091	T16090	arg2Of	n,(
R13106	T16091	T16092	arg1Of	n,=
R13107	T16091	T16093	arg1Of	n,4
R13108	T16094	T16090	arg3Of	),(
R13109	T16095	T16096	arg1Of	Controls,were
R13110	T16095	T16097	arg2Of	Controls,set
R13111	T16097	T16096	arg2Of	set,were
R13112	T16097	T16098	arg1Of	set,to
R13113	T16099	T16098	arg2Of	1,to
R13464	T16538	T16539	arg1Of	Involvement,of
R13465	T16538	T16543	arg1Of	Involvement,in
R13466	T16540	T16541	arg1Of	PKC,and
R13467	T16541	T16539	arg2Of	and,of
R13468	T16542	T16541	arg2Of	JNK,and
R13469	T16545	T16543	arg2Of	expression,in
R13470	T16545	T16544	arg1Of	expression,cytokine
R13471	T16547	T16546	arg1Of	T-cells,Jurkat
R13472	T16547	T16548	arg1Of	T-cells,were
R13473	T16547	T16549	arg2Of	T-cells,incubated
R13474	T16549	T16548	arg2Of	incubated,were
R13475	T16549	T16550	arg1Of	incubated,with
R13476	T16549	T16558	modOf	incubated,followed
R13477	T16551	T16552	arg1Of	PKC-,and
R13478	T16553	T16552	arg2Of	JNK,and
R13479	T16554	T16550	arg2Of	inhibitors,with
R13480	T16554	T16551	arg1Of	inhibitors,PKC-
R13481	T16554	T16553	arg1Of	inhibitors,JNK
R13482	T16554	T16555	arg1Of	inhibitors,for
R13483	T16557	T16555	arg2Of	h,for
R13484	T16557	T16556	arg1Of	h,1
R13485	T16558	T16567	arg1Of	followed,for
R13486	T16560	T16558	arg1Of	stimulation,followed
R13487	T16560	T16559	arg2Of	stimulation,by
R13488	T16560	T16561	arg1Of	stimulation,with
R13489	T16562	T16561	arg2Of	PMA,with
R13490	T16562	T16563	arg1Of	PMA,(
R13491	T16565	T16563	arg2Of	nM,(
R13492	T16565	T16564	arg1Of	nM,162
R13493	T16566	T16563	arg3Of	),(
R13494	T16569	T16567	arg2Of	h.,for
R13495	T16569	T16568	arg1Of	h.,24
R13496	T16569	T16570	arg1Of	h.,(
R13497	T16571	T16570	arg2Of	A,(
R13498	T16572	T16570	arg3Of	),(
R13499	T16574	T16573	arg1Of	expression,CXCL8
R13500	T16574	T16575	arg1Of	expression,was
R13501	T16574	T16576	arg2Of	expression,inhibited
R13502	T16576	T16575	arg2Of	inhibited,was
R13503	T16576	T16577	arg1Of	inhibited,in
R13504	T16580	T16577	arg2Of	manner,in
R13505	T16580	T16578	arg1Of	manner,a
R13506	T16580	T16579	arg1Of	manner,dose-dependent
R13507	T16583	T16576	arg1Of	inhibitors.,inhibited
R13508	T16583	T16581	arg2Of	inhibitors.,by
R13509	T16583	T16582	arg1Of	inhibitors.,both
R13510	T16583	T16584	arg1Of	inhibitors.,(
R13511	T16585	T16584	arg2Of	B,(
R13512	T16586	T16584	arg3Of	),(
R13513	T16587	T16588	arg1Of	JNK-I,revealed
R13514	T16588	T16548	modOf	revealed,were
R13515	T16588	T16575	modOf	revealed,was
R13516	T16592	T16588	arg2Of	effect,revealed
R13517	T16592	T16589	arg1Of	effect,a
R13518	T16592	T16590	arg1Of	effect,stronger
R13519	T16592	T16591	arg1Of	effect,inhibitory
R13520	T16592	T16593	arg1Of	effect,on
R13521	T16592	T16596	arg1Of	effect,than
R13522	T16595	T16593	arg2Of	expression,on
R13523	T16595	T16594	arg1Of	expression,IL-6
R13524	T16600	T16599	arg2Of	C,(
R13525	T16601	T16599	arg3Of	),(
R13526	T16603	T16597	arg1Of	expression,the
R13527	T16603	T16598	arg1Of	expression,PKC-I.
R13528	T16603	T16599	arg1Of	expression,(
R13529	T16603	T16602	arg1Of	expression,TNF
R13530	T16603	T16604	arg1Of	expression,was
R13531	T16603	T16606	arg2Of	expression,affected
R13532	T16606	T16596	arg2Of	affected,than
R13533	T16606	T16604	arg2Of	affected,was
R13534	T16606	T16605	arg1Of	affected,not
R13535	T16609	T16606	arg1Of	inhibitor,affected
R13536	T16609	T16607	arg2Of	inhibitor,by
R13537	T16609	T16608	arg1Of	inhibitor,either
R13538	T16611	T16610	arg1Of	significance,Statistical
R13539	T16611	T16612	arg1Of	significance,from
R13540	T16611	T16619	arg1Of	significance,was
R13541	T16611	T16620	arg2Of	significance,determined
R13542	T16615	T16612	arg2Of	control,from
R13543	T16615	T16613	arg1Of	control,the
R13544	T16615	T16614	arg1Of	control,positive
R13545	T16615	T16616	arg1Of	control,(
R13546	T16617	T16616	arg2Of	PMA,(
R13547	T16618	T16616	arg3Of	),(
R13548	T16620	T16619	arg2Of	determined,was
R13549	T16621	T16620	arg3Of	using,determined
R13550	T16622	T16623	arg2Of	Student,'s
R13551	T16624	T16621	arg2Of	t-test.,using
R13552	T16624	T16623	arg1Of	t-test.,'s
R13553	T16624	T16625	arg1Of	t-test.,(
R13554	T16626	T16625	arg2Of	n,(
R13555	T16626	T16627	arg1Of	n,=
R13556	T16626	T16628	arg1Of	n,3
R13557	T16629	T16625	arg3Of	),(
R13906	T17076	T17075	arg1Of	T-cells,Jurkat
R13907	T17076	T17077	arg1Of	T-cells,were
R13908	T17076	T17078	arg2Of	T-cells,treated
R13909	T17078	T17077	arg2Of	treated,were
R13910	T17078	T17079	arg1Of	treated,with
R13911	T17078	T17093	modOf	treated,followed
R13912	T17080	T17081	arg1Of	10,nM
R13913	T17082	T17080	arg1Of	NAI,10
R13914	T17082	T17083	arg1Of	NAI,","
R13915	T17083	T17079	arg2Of	",",with
R13916	T17083	T17090	arg1Of	",",for
R13917	T17089	T17083	arg2Of	PKC-I,","
R13918	T17089	T17084	arg1Of	PKC-I,10
R13919	T17089	T17085	arg1Of	PKC-I,μM
R13920	T17089	T17086	arg1Of	PKC-I,JNK-I
R13921	T17089	T17087	arg1Of	PKC-I,or10
R13922	T17089	T17088	arg1Of	PKC-I,nM
R13923	T17092	T17090	arg2Of	h,for
R13924	T17092	T17091	arg1Of	h,2
R13925	T17095	T17093	arg1Of	induction,followed
R13926	T17095	T17094	arg2Of	induction,by
R13927	T17095	T17096	arg1Of	induction,with
R13928	T17097	T17098	arg1Of	162,nM
R13929	T17099	T17096	arg2Of	PMA,with
R13930	T17099	T17097	arg1Of	PMA,162
R13931	T17099	T17100	arg1Of	PMA,for
R13932	T17102	T17100	arg2Of	h,for
R13933	T17102	T17101	arg1Of	h,24

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T16309	1692-1702	Anaphor	denotes	the levels
T16310	1610-1620	Antecedent	denotes	expression
T5509	3269-3279	Anaphor	denotes	the levels
T5510	3223-3229	Antecedent	denotes	levels
R13287	T16309	T16310	boundBy	the levels,expression
R4559	T5509	T5510	boundBy	the levels,levels

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T4767	0-11	NNP	denotes	Cooperative
T4768	12-21	NN	denotes	induction
T4769	22-24	IN	denotes	of
T4770	25-34	NNS	denotes	cytokines
T4771	35-37	IN	denotes	by
T4772	38-42	NNP	denotes	AP-1
T4773	43-46	CC	denotes	and
T4774	47-52	NNP	denotes	NF-κB
T4775	53-55	TO	denotes	To
T4776	56-63	RBR	denotes	further
T4777	64-76	VB	denotes	characterize
T4778	77-80	DT	denotes	the
T4779	81-92	NN	denotes	involvement
T4780	93-95	IN	denotes	of
T4783	105-113	NN	denotes	cytokine
T4784	114-124	NN	denotes	regulation
T4785	124-125	,	denotes	,
T4786	126-128	PRP	denotes	we
T4787	129-136	VBD	denotes	treated
T4788	137-142	NNS	denotes	cells
T4789	143-147	IN	denotes	with
T4790	148-150	DT	denotes	an
T4791	151-156	JJ	denotes	NF-κB
T4792	157-167	NN	denotes	activation
T4793	168-177	NN	denotes	inhibitor
T4794	178-179	-LRB-	denotes	(
T4795	179-182	NNP	denotes	NAI
T4796	182-183	-RRB-	denotes	)
T4797	183-184	.	denotes	.
T4798	185-188	DT	denotes	The
T4799	189-196	NNS	denotes	results
T4800	197-203	VBD	denotes	showed
T4801	204-208	IN	denotes	that
T4802	209-212	NNP	denotes	NAI
T4803	213-224	RB	denotes	selectively
T4804	225-239	VBD	denotes	down-regulated
T4805	240-245	JJ	denotes	NF-κB
T4806	246-256	NN	denotes	activation
T4807	257-258	-LRB-	denotes	(
T4808	258-265	NNS	denotes	figures
T4809	266-268	VBP	denotes	4a
T4810	269-272	CC	denotes	and
T4811	273-275	VBP	denotes	4b
T4812	275-276	-RRB-	denotes	)
T4813	277-280	CC	denotes	and
T4814	281-284	VBD	denotes	did
T4815	285-288	RB	denotes	not
T4816	289-294	VB	denotes	alter
T4817	295-299	JJ	denotes	AP-1
T4818	300-308	NN	denotes	activity
T4819	309-310	-LRB-	denotes	(
T4820	310-317	NNS	denotes	figures
T4821	318-320	VBP	denotes	4c
T4822	321-324	CC	denotes	and
T4823	325-327	VBP	denotes	4d
T4824	327-328	-RRB-	denotes	)
T4825	328-329	.	denotes	.
T4826	330-338	NN	denotes	Exposure
T4827	339-341	IN	denotes	of
T4828	342-348	NNP	denotes	Jurkat
T4829	349-356	NNS	denotes	T-cells
T4830	357-359	TO	denotes	to
T4831	360-363	NNP	denotes	NAI
T4832	364-372	VBD	denotes	resulted
T4833	373-375	IN	denotes	in
T4834	376-377	DT	denotes	a
T4835	378-384	JJ	denotes	modest
T4836	385-394	NN	denotes	reduction
T4837	395-397	IN	denotes	of
T4838	398-403	NNP	denotes	CXCL8
T4839	404-413	VBG	denotes	following
T4840	414-417	NNP	denotes	PMA
T4841	418-426	NN	denotes	exposure
T4842	426-427	,	denotes	,
T4843	428-433	IN	denotes	while
T4844	434-436	PRP	denotes	it
T4845	437-440	VBD	denotes	did
T4846	441-444	RB	denotes	not
T4847	445-450	VB	denotes	alter
T4848	451-454	DT	denotes	the
T4849	455-460	NNP	denotes	CXCL8
T4850	461-468	NN	denotes	release
T4851	469-478	VBG	denotes	following
T4852	479-481	NNP	denotes	HK
T4853	482-484	NNP	denotes	E.
T4854	485-489	NNS	denotes	coli
T4855	490-498	NN	denotes	exposure
T4856	499-500	-LRB-	denotes	(
T4857	500-506	NN	denotes	figure
T4858	507-509	NN	denotes	5a
T4859	509-510	-RRB-	denotes	)
T4860	510-511	.	denotes	.
T4861	512-515	NNP	denotes	NAI
T4862	516-519	VBD	denotes	did
T4863	520-523	RB	denotes	not
T4864	524-530	VB	denotes	affect
T4865	531-534	NNP	denotes	TNF
T4866	535-545	NN	denotes	expression
T4867	546-547	-LRB-	denotes	(
T4868	547-553	NN	denotes	figure
T4869	554-556	NN	denotes	5b
T4870	556-557	-RRB-	denotes	)
T4871	558-568	VBG	denotes	indicating
T4872	569-573	IN	denotes	that
T4873	574-579	NNP	denotes	NF-κB
T4874	580-582	VBZ	denotes	is
T4875	583-586	RB	denotes	not
T4876	587-590	DT	denotes	the
T4877	591-595	JJ	denotes	main
T4878	596-605	NN	denotes	regulator
T4879	606-608	IN	denotes	of
T4880	609-614	CD	denotes	CXCL8
T4881	615-617	CC	denotes	or
T4882	618-621	NNP	denotes	TNF
T4883	622-631	VBG	denotes	following
T4884	632-638	CC	denotes	either
T4885	639-642	NNP	denotes	PMA
T4886	643-645	CC	denotes	or
T4887	646-648	NNP	denotes	HK
T4888	649-651	NNP	denotes	E.
T4889	652-656	NNS	denotes	coli
T4890	657-665	NN	denotes	exposure
T4891	666-668	IN	denotes	in
T4892	669-675	NNP	denotes	Jurkat
T4893	676-683	NNS	denotes	T-cells
T4894	683-684	.	denotes	.
T4895	685-687	IN	denotes	In
T4896	688-696	NN	denotes	contrast
T4897	696-697	,	denotes	,
T4898	698-701	NNP	denotes	NAI
T4899	702-710	VBD	denotes	resulted
T4900	711-713	IN	denotes	in
T4901	714-715	DT	denotes	a
T4902	716-724	JJ	denotes	complete
T4903	725-735	NN	denotes	inhibition
T4904	736-738	IN	denotes	of
T4905	739-743	NN	denotes	IL-6
T4906	744-753	VBG	denotes	following
T4907	754-757	NNP	denotes	PMA
T4908	758-766	NN	denotes	exposure
T4909	767-770	CC	denotes	and
T4910	771-772	DT	denotes	a
T4911	773-775	CD	denotes	45
T4912	775-776	NN	denotes	%
T4913	777-787	NN	denotes	inhibition
T4914	788-797	VBG	denotes	following
T4915	798-800	NNP	denotes	HK
T4916	801-803	NNP	denotes	E.
T4917	804-808	NNS	denotes	coli
T4918	809-817	NN	denotes	exposure
T4919	818-819	-LRB-	denotes	(
T4920	819-825	NN	denotes	figure
T4921	826-828	NN	denotes	5c
T4922	828-829	-RRB-	denotes	)
T4923	829-830	,	denotes	,
T4924	831-841	VBG	denotes	suggesting
T4925	842-844	DT	denotes	an
T4926	845-856	NN	denotes	involvement
T4927	857-859	IN	denotes	of
T4928	860-865	NNP	denotes	NF-κB
T4929	866-868	IN	denotes	in
T4930	869-873	NNP	denotes	IL-6
T4931	874-884	NN	denotes	regulation
T4932	884-885	.	denotes	.
T4933	2183-2186	CD	denotes	Ca2
T4934	2186-2187	NN	denotes	+
T4935	2188-2191	VBD	denotes	was
T4936	2192-2200	VBN	denotes	observed
T4937	2201-2203	TO	denotes	to
T4938	2204-2212	VB	denotes	increase
T4939	2213-2217	JJ	denotes	AP-1
T4940	2218-2226	NN	denotes	activity
T4941	2227-2228	-LRB-	denotes	(
T4942	2228-2234	NN	denotes	figure
T4943	2235-2237	CD	denotes	1c
T4944	2237-2238	-RRB-	denotes	)
T4945	2239-2242	CC	denotes	and
T4946	2243-2249	VB	denotes	reduce
T4947	2250-2255	JJ	denotes	NF-κB
T4948	2256-2264	NN	denotes	activity
T4949	2265-2266	-LRB-	denotes	(
T4950	2266-2272	NN	denotes	figure
T4951	2273-2275	CD	denotes	2e
T4952	2275-2276	-RRB-	denotes	)
T4953	2276-2277	:	denotes	;
T4954	2278-2287	RB	denotes	therefore
T4955	2287-2288	,	denotes	,
T4956	2289-2291	PRP	denotes	we
T4957	2292-2299	VBD	denotes	exposed
T4958	2300-2307	NNS	denotes	T-cells
T4959	2308-2310	TO	denotes	to
T4960	2311-2312	DT	denotes	a
T4961	2313-2316	NNP	denotes	PKC
T4962	2317-2326	NN	denotes	inhibitor
T4963	2327-2335	RB	denotes	together
T4964	2336-2340	IN	denotes	with
T4965	2341-2344	NNP	denotes	PMA
T4966	2345-2347	TO	denotes	to
T4967	2348-2357	VB	denotes	determine
T4968	2358-2361	PRP$	denotes	its
T4969	2362-2368	NN	denotes	effect
T4970	2369-2371	IN	denotes	on
T4971	2372-2380	NN	denotes	cytokine
T4972	2381-2391	NN	denotes	expression
T4973	2391-2392	.	denotes	.
T4974	2393-2403	NNP	denotes	Inhibition
T4975	2404-2406	IN	denotes	of
T4976	2407-2410	NNP	denotes	PKC
T4977	2411-2418	VBD	denotes	reduced
T4978	2419-2424	CD	denotes	CXCL8
T4979	2425-2432	NN	denotes	release
T4980	2433-2437	IN	denotes	from
T4981	2438-2439	CD	denotes	7
T4982	2440-2445	NN	denotes	ng/ml
T4983	2446-2448	TO	denotes	to
T4984	2449-2450	CD	denotes	3
T4985	2451-2456	NN	denotes	ng/ml
T4986	2457-2462	IN	denotes	while
T4987	2463-2465	PRP	denotes	it
T4988	2466-2469	VBD	denotes	had
T4989	2470-2471	DT	denotes	a
T4990	2472-2478	JJ	denotes	modest
T4991	2479-2485	NN	denotes	effect
T4992	2486-2488	IN	denotes	on
T4993	2489-2493	NN	denotes	IL-6
T4994	2494-2497	CC	denotes	and
T4995	2498-2501	NNP	denotes	TNF
T4996	2502-2503	-LRB-	denotes	(
T5041	2760-2761	,	denotes	,
T5042	2762-2769	VBG	denotes	leading
T5043	2770-2772	TO	denotes	to
T5044	2773-2781	JJ	denotes	cellular
T5045	2782-2791	NN	denotes	apoptosis
T5046	2792-2793	NNP	denotes	[
T5047	2793-2795	CD	denotes	26
T5048	2795-2796	NNP	denotes	]
T5049	2796-2797	.	denotes	.
T5050	2798-2808	NNP	denotes	Inhibition
T5051	2809-2811	IN	denotes	of
T5052	2812-2815	DT	denotes	the
T5053	2816-2819	NNP	denotes	JNK
T5054	2820-2828	NNS	denotes	pathways
T5055	2829-2837	VBD	denotes	resulted
T5056	2838-2840	IN	denotes	in
T5057	2841-2842	DT	denotes	a
T5058	2843-2858	NN	denotes	down-regulation
T5059	2859-2861	IN	denotes	of
T5060	2862-2866	DT	denotes	both
T5061	2867-2872	CD	denotes	CXCL8
T5062	2873-2876	CC	denotes	and
T5063	2877-2881	NNP	denotes	IL-6
T5064	2881-2882	,	denotes	,
T5065	2883-2888	IN	denotes	while
T5066	2889-2891	DT	denotes	no
T5067	2892-2897	JJ	denotes	clear
T5068	2898-2904	NN	denotes	effect
T5069	2905-2908	VBD	denotes	was
T5070	2909-2917	VBN	denotes	observed
T5071	2918-2920	IN	denotes	on
T5072	2921-2924	NNP	denotes	TNF
T5073	2925-2935	NN	denotes	expression
T5074	2936-2937	-LRB-	denotes	(
T5075	2937-2943	NN	denotes	figure
T5076	2944-2948	JJ	denotes	6a-c
T5077	2948-2949	-RRB-	denotes	)
T5078	2949-2950	.	denotes	.
T5079	2951-2959	NN	denotes	Analysis
T5080	2960-2962	IN	denotes	of
T5081	2963-2967	NNP	denotes	mRNA
T5082	2968-2974	NNS	denotes	levels
T5083	2975-2980	VBG	denotes	using
T5084	2981-2988	NNP	denotes	RT-qPCR
T5085	2989-2990	-LRB-	denotes	(
T5086	2990-2995	NN	denotes	table
T5087	2996-2997	CD	denotes	2
T5088	2997-2998	-RRB-	denotes	)
T5089	2999-3005	VBD	denotes	showed
T5090	3006-3010	IN	denotes	that
T5091	3011-3014	NNP	denotes	PMA
T5092	3015-3022	VBD	denotes	induced
T5093	3023-3027	DT	denotes	both
T5094	3028-3032	JJ	denotes	il-6
T5095	3033-3036	CC	denotes	and
T5096	3037-3042	JJ	denotes	cxcl8
T5097	3043-3047	NNP	denotes	mRNA
T5098	3048-3049	-LRB-	denotes	(
T5099	3049-3057	JJ	denotes	5.1-fold
T5100	3058-3061	CC	denotes	and
T5101	3062-3067	CD	denotes	111.8
T5102	3068-3072	VBP	denotes	fold
T5103	3073-3085	RB	denotes	respectively
T5104	3085-3086	-RRB-	denotes	)
T5105	3086-3087	.	denotes	.
T5106	3088-3096	NN	denotes	Addition
T5107	3097-3099	IN	denotes	of
T5108	3100-3103	DT	denotes	the
T5109	3104-3109	JJ	denotes	NF-κB
T5110	3110-3119	NN	denotes	inhibitor
T5111	3120-3123	NNP	denotes	NAI
T5112	3124-3127	CC	denotes	and
T5113	3128-3131	DT	denotes	the
T5114	3132-3135	NNP	denotes	JNK
T5115	3136-3145	NN	denotes	inhibitor
T5116	3146-3153	VBD	denotes	reduced
T5117	3154-3157	DT	denotes	the
T5118	3158-3162	JJ	denotes	il-6
T5119	3163-3173	NN	denotes	expression
T5120	3174-3179	IN	denotes	below
T5121	3180-3185	JJ	denotes	basal
T5122	3186-3192	NNS	denotes	levels
T5123	3192-3193	.	denotes	.
T5124	3194-3196	IN	denotes	In
T5125	3197-3205	NN	denotes	contrast
T5126	3205-3206	,	denotes	,
T5127	3207-3212	IN	denotes	while
T5128	3213-3216	DT	denotes	the
T5129	3217-3222	JJ	denotes	cxcl8
T5130	3223-3229	NNS	denotes	levels
T5131	3230-3234	VBD	denotes	were
T5132	3235-3245	VBN	denotes	suppressed
T5133	3246-3248	IN	denotes	by
T5134	3249-3252	DT	denotes	the
T5135	3253-3257	JJ	denotes	same
T5136	3258-3268	NNS	denotes	treatments
T5137	3269-3272	DT	denotes	the
T5138	3273-3279	NNS	denotes	levels
T5139	3280-3288	VBD	denotes	remained
T5140	3289-3297	JJ	denotes	elevated
T5141	3298-3303	IN	denotes	above
T5142	3304-3309	JJ	denotes	basal
T5143	3310-3315	NN	denotes	level
T5144	3315-3316	.	denotes	.
T15876	896-906	NNP	denotes	Inhibition
T15877	907-909	IN	denotes	of
T15878	910-915	JJ	denotes	NF-κB
T15879	916-924	NN	denotes	activity
T15880	925-927	IN	denotes	by
T15881	928-931	NNP	denotes	NAI
T15882	931-932	.	denotes	.
T15883	933-939	NNP	denotes	Jurkat
T15884	940-947	NNS	denotes	T-cells
T15885	948-952	VBD	denotes	were
T15886	953-964	VBN	denotes	transfected
T15887	965-969	IN	denotes	with
T15888	970-980	NN	denotes	luciferase
T15889	981-989	NN	denotes	reporter
T15890	990-998	NNS	denotes	plasmids
T15891	999-1009	VBG	denotes	containing
T15892	1010-1016	CC	denotes	either
T15893	1017-1022	NNP	denotes	NF-κB
T15894	1023-1025	CC	denotes	or
T15895	1026-1030	NNP	denotes	AP-1
T15896	1031-1041	JJ	denotes	cis-acting
T15897	1042-1050	NNS	denotes	elements
T15898	1050-1051	.	denotes	.
T15899	1052-1055	DT	denotes	The
T15900	1056-1061	NNS	denotes	cells
T15901	1062-1066	VBD	denotes	were
T15902	1067-1076	VBN	denotes	incubated
T15903	1077-1081	IN	denotes	with
T15904	1082-1087	JJ	denotes	NF-κB
T15905	1088-1098	NN	denotes	activation
T15906	1099-1108	NN	denotes	inhibitor
T15907	1109-1110	-LRB-	denotes	(
T15908	1110-1113	NNP	denotes	NAI
T15909	1113-1114	-RRB-	denotes	)
T15910	1115-1118	IN	denotes	for
T15911	1119-1120	CD	denotes	1
T15912	1121-1122	NN	denotes	h
T15913	1123-1131	VBN	denotes	followed
T15914	1132-1134	IN	denotes	by
T15915	1135-1146	NN	denotes	stimulation
T15916	1147-1151	IN	denotes	with
T15917	1152-1155	NNP	denotes	PMA
T15918	1156-1157	-LRB-	denotes	(
T15919	1157-1160	CD	denotes	162
T15920	1161-1163	NNP	denotes	nM
T15921	1163-1164	,	denotes	,
T15922	1165-1166	NNP	denotes	A
T15923	1167-1170	CC	denotes	and
T15924	1171-1172	NNP	denotes	C
T15925	1172-1173	-RRB-	denotes	)
T15926	1174-1176	CC	denotes	or
T15927	1177-1179	NNP	denotes	HK
T15928	1180-1182	NNP	denotes	E.
T15929	1183-1187	NNS	denotes	coli
T15930	1188-1189	-LRB-	denotes	(
T15931	1189-1190	CD	denotes	5
T15932	1191-1192	CD	denotes	×
T15933	1193-1196	CD	denotes	107
T15934	1197-1203	NNP	denotes	CFU/ml
T15935	1203-1204	,	denotes	,
T15936	1205-1206	NNP	denotes	B
T15937	1207-1210	CC	denotes	and
T15938	1211-1212	NNP	denotes	D
T15939	1212-1213	-RRB-	denotes	)
T15940	1214-1217	IN	denotes	for
T15941	1218-1220	CD	denotes	24
T15942	1221-1223	NN	denotes	h.
T15943	1224-1225	-LRB-	denotes	(
T15944	1225-1226	DT	denotes	A
T15945	1226-1227	,	denotes	,
T15946	1228-1229	NNP	denotes	B
T15947	1229-1230	-RRB-	denotes	)
T15948	1231-1236	NNP	denotes	NF-κB
T15949	1236-1237	,	denotes	,
T15950	1238-1241	CC	denotes	but
T15951	1242-1245	RB	denotes	not
T15952	1246-1247	-LRB-	denotes	(
T15953	1247-1248	NNP	denotes	C
T15954	1248-1249	,	denotes	,
T15955	1250-1251	NNP	denotes	D
T15956	1251-1252	-RRB-	denotes	)
T15957	1253-1257	NN	denotes	AP-1
T15958	1258-1261	VBD	denotes	was
T15959	1262-1271	VBN	denotes	inhibited
T15960	1271-1272	.	denotes	.
T15961	1273-1284	NNP	denotes	Statistical
T15962	1285-1297	NN	denotes	significance
T15963	1298-1302	IN	denotes	from
T15964	1303-1306	DT	denotes	the
T15965	1307-1315	JJ	denotes	positive
T15966	1316-1323	NN	denotes	control
T15967	1324-1325	-LRB-	denotes	(
T15968	1325-1331	NNP	denotes	PMA/HK
T15969	1332-1334	NNP	denotes	E.
T15970	1335-1339	NNS	denotes	coli
T15971	1339-1340	-RRB-	denotes	)
T15972	1341-1344	VBD	denotes	was
T15973	1345-1355	VBN	denotes	determined
T15974	1356-1361	VBG	denotes	using
T15975	1362-1369	NN	denotes	Student
T15976	1369-1371	POS	denotes	's
T15977	1372-1378	JJS	denotes	t-test
T15978	1378-1379	.	denotes	.
T15979	1380-1381	-LRB-	denotes	(
T15980	1381-1382	FW	denotes	n
T15981	1383-1384	SYM	denotes	=
T15982	1385-1386	LS	denotes	4
T15983	1386-1387	-RRB-	denotes	)
T15984	1387-1388	.	denotes	.
T15985	1389-1397	NNP	denotes	Controls
T15986	1398-1402	VBD	denotes	were
T15987	1403-1406	VBN	denotes	set
T15988	1407-1409	TO	denotes	to
T15989	1410-1411	CD	denotes	1
T15990	1411-1412	.	denotes	.
T16168	1423-1434	NN	denotes	Involvement
T16169	1435-1437	IN	denotes	of
T16170	1438-1443	NN	denotes	NF-κB
T16171	1444-1446	IN	denotes	in
T16172	1447-1455	NN	denotes	cytokine
T16173	1456-1466	NN	denotes	regulation
T16174	1466-1467	.	denotes	.
T16175	1468-1486	JJ	denotes	Cytokine/chemokine
T16176	1487-1493	NNS	denotes	levels
T16177	1494-1498	VBD	denotes	were
T16178	1499-1509	VBN	denotes	determined
T16179	1510-1515	VBG	denotes	using
T16180	1516-1521	NNP	denotes	ELISA
T16181	1522-1531	VBG	denotes	following
T16182	1532-1542	NN	denotes	incubation
T16183	1543-1545	IN	denotes	of
T16184	1546-1552	NNP	denotes	Jurkat
T16185	1553-1560	NNS	denotes	T-cells
T16186	1561-1565	IN	denotes	with
T16187	1566-1569	NNP	denotes	NAI
T16188	1570-1571	-LRB-	denotes	(
T16189	1571-1572	CD	denotes	1
T16190	1573-1574	NN	denotes	h
T16191	1574-1575	-RRB-	denotes	)
T16192	1576-1579	CC	denotes	and
T16193	1580-1591	NN	denotes	stimulation
T16194	1592-1593	-LRB-	denotes	(
T16195	1593-1595	CD	denotes	24
T16196	1596-1597	NN	denotes	h
T16197	1597-1598	-RRB-	denotes	)
T16198	1598-1599	.	denotes	.
T16199	1600-1601	-LRB-	denotes	(
T16200	1601-1602	NNP	denotes	A
T16201	1602-1603	-RRB-	denotes	)
T16202	1604-1609	NNP	denotes	CXCL8
T16203	1610-1620	NN	denotes	expression
T16204	1621-1624	VBD	denotes	was
T16205	1625-1634	RB	denotes	partially
T16206	1635-1644	VBN	denotes	inhibited
T16207	1645-1654	VBG	denotes	following
T16208	1655-1658	NNP	denotes	PMA
T16209	1659-1670	NN	denotes	stimulation
T16210	1671-1672	-LRB-	denotes	(
T16211	1672-1676	NN	denotes	grey
T16212	1677-1681	NNS	denotes	bars
T16213	1681-1682	-RRB-	denotes	)
T16214	1682-1683	,	denotes	,
T16215	1684-1691	IN	denotes	whereas
T16216	1692-1695	DT	denotes	the
T16217	1696-1702	NNS	denotes	levels
T16218	1703-1707	VBD	denotes	were
T16219	1708-1711	RB	denotes	not
T16220	1712-1719	VBN	denotes	altered
T16221	1720-1729	VBG	denotes	following
T16222	1730-1741	NN	denotes	stimulation
T16223	1742-1746	IN	denotes	with
T16224	1747-1749	NNP	denotes	HK
T16225	1750-1752	NNP	denotes	E.
T16226	1753-1757	NNS	denotes	coli
T16227	1758-1759	-LRB-	denotes	(
T16228	1759-1764	JJ	denotes	black
T16229	1765-1769	NNS	denotes	bars
T16230	1769-1770	-RRB-	denotes	)
T16231	1770-1771	,	denotes	,
T16232	1772-1776	DT	denotes	this
T16233	1777-1786	VBZ	denotes	indicates
T16234	1787-1789	DT	denotes	an
T16235	1790-1799	NN	denotes	induction
T16236	1800-1806	RB	denotes	mainly
T16237	1807-1816	VBN	denotes	regulated
T16238	1817-1819	IN	denotes	by
T16239	1820-1824	NN	denotes	AP-1
T16240	1824-1825	.	denotes	.
T16241	1826-1827	-LRB-	denotes	(
T16242	1827-1828	NNP	denotes	B
T16243	1828-1829	-RRB-	denotes	)
T16244	1830-1833	NNP	denotes	TNF
T16245	1834-1844	NN	denotes	expression
T16246	1845-1848	VBD	denotes	was
T16247	1849-1852	RB	denotes	not
T16248	1853-1861	VBN	denotes	affected
T16249	1862-1864	IN	denotes	by
T16250	1865-1868	NNP	denotes	NAI
T16251	1868-1869	.	denotes	.
T16252	1870-1871	-LRB-	denotes	(
T16253	1871-1872	$	denotes	C
T16254	1872-1873	-RRB-	denotes	)
T16255	1874-1878	NN	denotes	IL-6
T16256	1879-1886	NN	denotes	release
T16257	1887-1890	VBD	denotes	was
T16258	1891-1901	RB	denotes	completely
T16259	1902-1911	VBN	denotes	inhibited
T16260	1912-1914	IN	denotes	by
T16261	1915-1918	NNP	denotes	NAI
T16262	1919-1928	VBG	denotes	following
T16263	1929-1932	NNP	denotes	PMA
T16264	1933-1941	NN	denotes	exposure
T16265	1941-1942	,	denotes	,
T16266	1943-1953	VBG	denotes	indicating
T16267	1954-1964	NN	denotes	regulation
T16268	1965-1972	IN	denotes	through
T16269	1973-1978	NNP	denotes	NF-κB
T16270	1979-1984	IN	denotes	since
T16271	1985-1989	NNP	denotes	IL-6
T16272	1990-2000	NN	denotes	expression
T16273	2001-2004	VBD	denotes	was
T16274	2005-2018	RB	denotes	significantly
T16275	2019-2028	VBN	denotes	increased
T16276	2029-2031	IN	denotes	in
T16277	2032-2040	NN	denotes	response
T16278	2041-2043	TO	denotes	to
T16279	2044-2046	NNP	denotes	HK
T16280	2047-2049	NNP	denotes	E.
T16281	2050-2054	NNS	denotes	coli
T16282	2055-2059	IN	denotes	than
T16283	2060-2063	NNP	denotes	PMA
T16284	2063-2064	.	denotes	.
T16285	2065-2076	NNP	denotes	Statistical
T16286	2077-2089	NN	denotes	significance
T16287	2090-2094	IN	denotes	from
T16288	2095-2098	DT	denotes	the
T16289	2099-2107	JJ	denotes	positive
T16290	2108-2115	NN	denotes	control
T16291	2116-2117	-LRB-	denotes	(
T16292	2117-2123	NNP	denotes	PMA/HK
T16293	2124-2126	NNP	denotes	E.
T16294	2127-2131	NNS	denotes	coli
T16295	2131-2132	-RRB-	denotes	)
T16296	2133-2136	VBD	denotes	was
T16297	2137-2147	VBN	denotes	determined
T16298	2148-2153	VBG	denotes	using
T16299	2154-2161	NN	denotes	Student
T16300	2161-2163	POS	denotes	's
T16301	2164-2170	JJS	denotes	t-test
T16302	2170-2171	.	denotes	.
T16303	2172-2173	-LRB-	denotes	(
T16304	2173-2174	FW	denotes	n
T16305	2175-2176	SYM	denotes	=
T16306	2177-2178	LS	denotes	3
T16307	2178-2179	-RRB-	denotes	)
T16308	2179-2180	.	denotes	.
T16439	3327-3338	NN	denotes	Involvement
T16440	3339-3341	IN	denotes	of
T16441	3342-3345	NNP	denotes	PKC
T16442	3346-3349	CC	denotes	and
T16443	3350-3353	NNP	denotes	JNK
T16444	3354-3356	IN	denotes	in
T16445	3357-3365	NN	denotes	cytokine
T16446	3366-3376	NN	denotes	expression
T16447	3376-3377	.	denotes	.
T16448	3378-3384	NNP	denotes	Jurkat
T16449	3385-3392	NNS	denotes	T-cells
T16450	3393-3397	VBD	denotes	were
T16451	3398-3407	VBN	denotes	incubated
T16452	3408-3412	IN	denotes	with
T16453	3413-3416	NNP	denotes	PKC
T16454	3416-3417	:	denotes	-
T16455	3418-3421	CC	denotes	and
T16456	3422-3425	NNP	denotes	JNK
T16457	3426-3436	NNS	denotes	inhibitors
T16458	3437-3440	IN	denotes	for
T16459	3441-3442	CD	denotes	1
T16460	3443-3444	NN	denotes	h
T16461	3445-3453	VBN	denotes	followed
T16462	3454-3456	IN	denotes	by
T16463	3457-3468	NN	denotes	stimulation
T16464	3469-3473	IN	denotes	with
T16465	3474-3477	NNP	denotes	PMA
T16466	3478-3479	-LRB-	denotes	(
T16467	3479-3482	CD	denotes	162
T16468	3483-3485	NNP	denotes	nM
T16469	3485-3486	-RRB-	denotes	)
T16470	3487-3490	IN	denotes	for
T16471	3491-3493	CD	denotes	24
T16472	3494-3496	NN	denotes	h.
T16473	3497-3498	-LRB-	denotes	(
T16474	3498-3499	NNP	denotes	A
T16475	3499-3500	-RRB-	denotes	)
T16476	3501-3506	NNP	denotes	CXCL8
T16477	3507-3517	NN	denotes	expression
T16478	3518-3521	VBD	denotes	was
T16479	3522-3531	VBN	denotes	inhibited
T16480	3532-3534	IN	denotes	in
T16481	3535-3536	DT	denotes	a
T16482	3537-3551	JJ	denotes	dose-dependent
T16483	3552-3558	NN	denotes	manner
T16484	3559-3561	IN	denotes	by
T16485	3562-3566	DT	denotes	both
T16486	3567-3577	NNS	denotes	inhibitors
T16487	3577-3578	.	denotes	.
T16488	3579-3580	-LRB-	denotes	(
T16489	3580-3581	NNP	denotes	B
T16490	3581-3582	-RRB-	denotes	)
T16491	3583-3588	NNP	denotes	JNK-I
T16492	3589-3597	VBD	denotes	revealed
T16493	3598-3599	DT	denotes	a
T16494	3600-3608	JJR	denotes	stronger
T16495	3609-3619	JJ	denotes	inhibitory
T16496	3620-3626	NN	denotes	effect
T16497	3627-3629	IN	denotes	on
T16498	3630-3634	NN	denotes	IL-6
T16499	3635-3645	NN	denotes	expression
T16500	3646-3650	IN	denotes	than
T16501	3651-3654	DT	denotes	the
T16502	3655-3660	NNP	denotes	PKC-I
T16503	3660-3661	.	denotes	.
T16504	3662-3663	-LRB-	denotes	(
T16505	3663-3664	NNP	denotes	C
T16506	3664-3665	-RRB-	denotes	)
T16507	3666-3669	NNP	denotes	TNF
T16508	3670-3680	NN	denotes	expression
T16509	3681-3684	VBD	denotes	was
T16510	3685-3688	RB	denotes	not
T16511	3689-3697	VBN	denotes	affected
T16512	3698-3700	IN	denotes	by
T16513	3701-3707	DT	denotes	either
T16514	3708-3717	NN	denotes	inhibitor
T16515	3717-3718	.	denotes	.
T16516	3719-3730	NNP	denotes	Statistical
T16517	3731-3743	NN	denotes	significance
T16518	3744-3748	IN	denotes	from
T16519	3749-3752	DT	denotes	the
T16520	3753-3761	JJ	denotes	positive
T16521	3762-3769	NN	denotes	control
T16522	3770-3771	-LRB-	denotes	(
T16523	3771-3774	NNP	denotes	PMA
T16524	3774-3775	-RRB-	denotes	)
T16525	3776-3779	VBD	denotes	was
T16526	3780-3790	VBN	denotes	determined
T16527	3791-3796	VBG	denotes	using
T16528	3797-3804	NN	denotes	Student
T16529	3804-3806	POS	denotes	's
T16530	3807-3813	JJS	denotes	t-test
T16531	3813-3814	.	denotes	.
T16532	3815-3816	-LRB-	denotes	(
T16533	3816-3817	FW	denotes	n
T16534	3818-3819	SYM	denotes	=
T16535	3820-3821	LS	denotes	3
T16536	3821-3822	-RRB-	denotes	)
T16537	3822-3823	.	denotes	.
T17047	3833-3839	NNP	denotes	Jurkat
T17048	3840-3847	NNS	denotes	T-cells
T17049	3848-3852	VBD	denotes	were
T17050	3853-3860	VBN	denotes	treated
T17051	3861-3865	IN	denotes	with
T17052	3866-3868	CD	denotes	10
T17053	3869-3871	NNP	denotes	nM
T17054	3872-3875	NNP	denotes	NAI
T17055	3875-3876	,	denotes	,
T17056	3877-3879	CD	denotes	10
T17057	3880-3882	NNP	denotes	μM
T17058	3883-3888	NNP	denotes	JNK-I
T17059	3889-3893	CD	denotes	or10
T17060	3894-3896	NNP	denotes	nM
T17061	3897-3902	NNP	denotes	PKC-I
T17062	3903-3906	IN	denotes	for
T17063	3907-3908	CD	denotes	2
T17064	3909-3910	NN	denotes	h
T17065	3911-3919	VBN	denotes	followed
T17066	3920-3922	IN	denotes	by
T17067	3923-3932	NN	denotes	induction
T17068	3933-3937	IN	denotes	with
T17069	3938-3941	CD	denotes	162
T17070	3942-3944	NNP	denotes	nM
T17071	3945-3948	NNP	denotes	PMA
T17072	3949-3952	IN	denotes	for
T17073	3953-3955	CD	denotes	24
T17074	3956-3958	NN	denotes	h.
T4781	96-101	NN	denotes	NF-κB
T4782	102-104	IN	denotes	in
T4997	2503-2509	NN	denotes	figure
T4998	2510-2514	JJ	denotes	6a-c
T4999	2514-2515	-RRB-	denotes	)
T5000	2515-2516	.	denotes	.
T5001	2517-2521	DT	denotes	This
T5002	2522-2530	VBD	denotes	prompted
T5003	2531-2533	PRP	denotes	us
T5004	2534-2536	TO	denotes	to
T5005	2537-2541	VB	denotes	test
T5006	2542-2545	DT	denotes	the
T5007	2546-2552	NN	denotes	effect
T5008	2553-2555	IN	denotes	of
T5009	2556-2559	NNP	denotes	JNK
T5010	2560-2570	NN	denotes	inhibition
T5011	2571-2573	IN	denotes	on
T5012	2574-2585	JJ	denotes	PMA-induced
T5013	2586-2594	NN	denotes	cytokine
T5014	2595-2605	NN	denotes	expression
T5015	2605-2606	.	denotes	.
T5016	2607-2610	NNP	denotes	JNK
T5017	2611-2613	VBZ	denotes	is
T5018	2614-2622	VBN	denotes	involved
T5019	2623-2625	IN	denotes	in
T5020	2626-2629	DT	denotes	the
T5021	2630-2640	NN	denotes	regulation
T5022	2641-2643	IN	denotes	of
T5023	2644-2645	DT	denotes	a
T5024	2646-2655	NN	denotes	multitude
T5025	2656-2658	IN	denotes	of
T5026	2659-2668	JJ	denotes	different
T5027	2669-2682	NN	denotes	transcription
T5028	2683-2690	NNS	denotes	factors
T5029	2690-2691	,	denotes	,
T5030	2692-2701	VBG	denotes	including
T5031	2702-2705	DT	denotes	the
T5032	2706-2721	NN	denotes	phosphorylation
T5033	2722-2725	CC	denotes	and
T5034	2726-2736	NN	denotes	activation
T5035	2737-2739	IN	denotes	of
T5036	2740-2745	NNP	denotes	c-Jun
T5037	2745-2746	,	denotes	,
T5038	2747-2752	NNP	denotes	c-Fos
T5039	2753-2756	CC	denotes	and
T5040	2757-2760	NN	denotes	p53
R3816	T4767	T4768	amod	Cooperative,induction
R3817	T4768	T4787	nsubj	induction,treated
R3818	T4769	T4768	prep	of,induction
R3819	T4770	T4769	pobj	cytokines,of
R3820	T4771	T4768	prep	by,induction
R3821	T4772	T4771	pobj	AP-1,by
R3822	T4773	T4772	cc	and,AP-1
R3823	T4774	T4772	conj	NF-κB,AP-1
R3824	T4775	T4777	aux	To,characterize
R3825	T4776	T4777	advmod	further,characterize
R3826	T4777	T4787	advcl	characterize,treated
R3827	T4778	T4779	det	the,involvement
R3828	T4779	T4777	dobj	involvement,characterize
R3829	T4780	T4779	prep	of,involvement
R3830	T4781	T4780	pobj	NF-κB,of
R3831	T4782	T4779	prep	in,involvement
R3832	T4783	T4784	compound	cytokine,regulation
R3833	T4784	T4782	pobj	regulation,in
R3834	T4785	T4787	punct	",",treated
R3835	T4786	T4787	nsubj	we,treated
R3836	T4787	T4787	ROOT	treated,treated
R3837	T4788	T4787	dobj	cells,treated
R3838	T4789	T4787	prep	with,treated
R3839	T4790	T4793	det	an,inhibitor
R3840	T4791	T4793	amod	NF-κB,inhibitor
R3841	T4792	T4793	compound	activation,inhibitor
R3842	T4793	T4789	pobj	inhibitor,with
R3843	T4794	T4793	punct	(,inhibitor
R3844	T4795	T4793	appos	NAI,inhibitor
R3845	T4796	T4793	punct	),inhibitor
R3846	T4797	T4787	punct	.,treated
R3847	T4798	T4799	det	The,results
R3848	T4799	T4800	nsubj	results,showed
R3849	T4800	T4800	ROOT	showed,showed
R3850	T4801	T4804	mark	that,down-regulated
R3851	T4802	T4804	nsubj	NAI,down-regulated
R3852	T4803	T4804	advmod	selectively,down-regulated
R3854	T4805	T4806	amod	NF-κB,activation
R3855	T4806	T4804	dobj	activation,down-regulated
R3856	T4807	T4809	punct	(,4a
R3857	T4808	T4809	nsubj	figures,4a
R3858	T4809	T4806	appos	4a,activation
R3859	T4810	T4809	cc	and,4a
R3860	T4811	T4809	conj	4b,4a
R3861	T4812	T4809	punct	),4a
R3862	T4813	T4804	cc	and,down-regulated
R3863	T4814	T4816	aux	did,alter
R3864	T4815	T4816	neg	not,alter
R3865	T4816	T4804	conj	alter,down-regulated
R3866	T4817	T4818	amod	AP-1,activity
R3867	T4818	T4816	dobj	activity,alter
R3868	T4819	T4821	punct	(,4c
R3869	T4820	T4821	nsubj	figures,4c
R3870	T4821	T4816	parataxis	4c,alter
R3871	T4822	T4821	cc	and,4c
R3872	T4823	T4821	conj	4d,4c
R3873	T4824	T4821	punct	),4c
R3874	T4825	T4800	punct	.,showed
R3875	T4826	T4832	nsubj	Exposure,resulted
R3876	T4827	T4826	prep	of,Exposure
R3877	T4828	T4829	compound	Jurkat,T-cells
R3878	T4829	T4827	pobj	T-cells,of
R3879	T4830	T4826	prep	to,Exposure
R3880	T4831	T4830	pobj	NAI,to
R3881	T4832	T4832	ROOT	resulted,resulted
R3882	T4833	T4832	prep	in,resulted
R3883	T4834	T4836	det	a,reduction
R3884	T4835	T4836	amod	modest,reduction
R3885	T4836	T4833	pobj	reduction,in
R3886	T4837	T4836	prep	of,reduction
R3887	T4838	T4837	pobj	CXCL8,of
R3888	T4839	T4836	prep	following,reduction
R3889	T4840	T4841	compound	PMA,exposure
R3890	T4841	T4839	pobj	exposure,following
R3891	T4842	T4832	punct	",",resulted
R3892	T4843	T4847	mark	while,alter
R3893	T4844	T4847	nsubj	it,alter
R3894	T4845	T4847	aux	did,alter
R3895	T4846	T4847	neg	not,alter
R3896	T4847	T4832	advcl	alter,resulted
R3897	T4848	T4850	det	the,release
R3898	T4849	T4850	compound	CXCL8,release
R3899	T4850	T4847	dobj	release,alter
R3900	T4851	T4850	acl	following,release
R3901	T4852	T4855	nmod	HK,exposure
R3902	T4853	T4855	compound	E.,exposure
R3903	T4854	T4855	compound	coli,exposure
R3904	T4855	T4851	pobj	exposure,following
R3905	T4856	T4858	punct	(,5a
R3906	T4857	T4858	compound	figure,5a
R3907	T4858	T4855	appos	5a,exposure
R3908	T4859	T4858	punct	),5a
R3909	T4860	T4832	punct	.,resulted
R3910	T4861	T4864	nsubj	NAI,affect
R3911	T4862	T4864	aux	did,affect
R3912	T4863	T4864	neg	not,affect
R3913	T4864	T4864	ROOT	affect,affect
R3914	T4865	T4866	compound	TNF,expression
R3915	T4866	T4864	dobj	expression,affect
R3916	T4867	T4869	punct	(,5b
R3917	T4868	T4869	compound	figure,5b
R3918	T4869	T4866	appos	5b,expression
R3919	T4870	T4864	punct	),affect
R3920	T4871	T4864	advcl	indicating,affect
R3921	T4872	T4874	mark	that,is
R3922	T4873	T4874	nsubj	NF-κB,is
R3923	T4874	T4871	ccomp	is,indicating
R3924	T4875	T4874	neg	not,is
R3925	T4876	T4878	det	the,regulator
R3926	T4877	T4878	amod	main,regulator
R3927	T4878	T4874	attr	regulator,is
R3928	T4879	T4878	prep	of,regulator
R3929	T4880	T4879	pobj	CXCL8,of
R3930	T4881	T4880	cc	or,CXCL8
R3931	T4882	T4880	conj	TNF,CXCL8
R3932	T4883	T4878	prep	following,regulator
R3933	T4884	T4885	preconj	either,PMA
R3934	T4885	T4883	pobj	PMA,following
R3935	T4886	T4885	cc	or,PMA
R3936	T4887	T4890	compound	HK,exposure
R3937	T4888	T4889	compound	E.,coli
R3938	T4889	T4890	compound	coli,exposure
R3939	T4890	T4885	conj	exposure,PMA
R3940	T4891	T4890	prep	in,exposure
R3941	T4892	T4893	compound	Jurkat,T-cells
R3942	T4893	T4891	pobj	T-cells,in
R3943	T4894	T4864	punct	.,affect
R3944	T4895	T4899	prep	In,resulted
R3945	T4896	T4895	pobj	contrast,In
R3946	T4897	T4899	punct	",",resulted
R3947	T4898	T4899	nsubj	NAI,resulted
R3948	T4899	T4899	ROOT	resulted,resulted
R3949	T4900	T4899	prep	in,resulted
R3950	T4901	T4903	det	a,inhibition
R3951	T4902	T4903	amod	complete,inhibition
R3952	T4903	T4900	pobj	inhibition,in
R3953	T4904	T4903	prep	of,inhibition
R3954	T4905	T4904	pobj	IL-6,of
R3955	T4906	T4899	prep	following,resulted
R3956	T4907	T4908	compound	PMA,exposure
R3957	T4908	T4906	pobj	exposure,following
R3958	T4909	T4908	cc	and,exposure
R3959	T4910	T4913	det	a,inhibition
R3960	T4911	T4912	nummod	45,%
R3961	T4912	T4913	compound	%,inhibition
R3962	T4913	T4908	conj	inhibition,exposure
R3963	T4914	T4908	prep	following,exposure
R3964	T4915	T4918	nmod	HK,exposure
R3965	T4916	T4918	compound	E.,exposure
R3966	T4917	T4918	compound	coli,exposure
R3967	T4918	T4914	pobj	exposure,following
R3968	T4919	T4921	punct	(,5c
R3969	T4920	T4921	compound	figure,5c
R3970	T4921	T4918	appos	5c,exposure
R3971	T4922	T4921	punct	),5c
R3972	T4923	T4899	punct	",",resulted
R3973	T4924	T4899	advcl	suggesting,resulted
R3974	T4925	T4926	det	an,involvement
R3975	T4926	T4924	dobj	involvement,suggesting
R3976	T4927	T4926	prep	of,involvement
R3977	T4928	T4927	pobj	NF-κB,of
R3978	T4929	T4928	prep	in,NF-κB
R3979	T4930	T4931	compound	IL-6,regulation
R3980	T4931	T4929	pobj	regulation,in
R3981	T4932	T4899	punct	.,resulted
R3982	T4933	T4934	nummod	Ca2,+
R3983	T4934	T4936	nsubjpass	+,observed
R3984	T4935	T4936	auxpass	was,observed
R3985	T4936	T4957	ccomp	observed,exposed
R3986	T4937	T4938	aux	to,increase
R3987	T4938	T4936	xcomp	increase,observed
R3988	T4939	T4940	amod	AP-1,activity
R3989	T4940	T4938	dobj	activity,increase
R3990	T4941	T4942	punct	(,figure
R3991	T4942	T4938	parataxis	figure,increase
R3992	T4943	T4942	nummod	1c,figure
R3993	T4944	T4942	punct	),figure
R3994	T4945	T4938	cc	and,increase
R3995	T4946	T4938	conj	reduce,increase
R3996	T4947	T4948	amod	NF-κB,activity
R3997	T4948	T4946	dobj	activity,reduce
R3998	T4949	T4950	punct	(,figure
R3999	T4950	T4957	ccomp	figure,exposed
R4000	T4951	T4950	nummod	2e,figure
R4001	T4952	T4950	punct	),figure
R4002	T4953	T4957	punct	;,exposed
R4003	T4954	T4957	advmod	therefore,exposed
R4004	T4955	T4957	punct	",",exposed
R4005	T4956	T4957	nsubj	we,exposed
R4006	T4957	T4957	ROOT	exposed,exposed
R4007	T4958	T4957	dobj	T-cells,exposed
R4008	T4959	T4957	prep	to,exposed
R4009	T4960	T4962	det	a,inhibitor
R4010	T4961	T4962	compound	PKC,inhibitor
R4011	T4962	T4959	pobj	inhibitor,to
R4012	T4963	T4964	advmod	together,with
R4013	T4964	T4957	prep	with,exposed
R4014	T4965	T4964	pobj	PMA,with
R4015	T4966	T4967	aux	to,determine
R4016	T4967	T4957	advcl	determine,exposed
R4017	T4968	T4969	poss	its,effect
R4018	T4969	T4967	dobj	effect,determine
R4019	T4970	T4969	prep	on,effect
R4020	T4971	T4972	amod	cytokine,expression
R4021	T4972	T4970	pobj	expression,on
R4022	T4973	T4957	punct	.,exposed
R4023	T4974	T4977	nsubj	Inhibition,reduced
R4024	T4975	T4974	prep	of,Inhibition
R4025	T4976	T4975	pobj	PKC,of
R4026	T4977	T4977	ROOT	reduced,reduced
R4027	T4978	T4979	nummod	CXCL8,release
R4028	T4979	T4977	dobj	release,reduced
R4029	T4980	T4977	prep	from,reduced
R4030	T4981	T4982	nummod	7,ng/ml
R4031	T4982	T4980	pobj	ng/ml,from
R4032	T4983	T4977	prep	to,reduced
R4033	T4984	T4985	nummod	3,ng/ml
R4034	T4985	T4983	pobj	ng/ml,to
R4035	T4986	T4988	mark	while,had
R4036	T4987	T4988	nsubj	it,had
R4037	T4988	T4977	advcl	had,reduced
R4038	T4989	T4991	det	a,effect
R4039	T4990	T4991	amod	modest,effect
R4040	T4991	T4988	dobj	effect,had
R4041	T4992	T4991	prep	on,effect
R4042	T4993	T4992	pobj	IL-6,on
R4043	T4994	T4993	cc	and,IL-6
R4044	T4995	T4993	conj	TNF,IL-6
R4045	T4996	T4997	punct	(,figure
R4046	T4997	T4998	nsubj	figure,6a-c
R4047	T4998	T4995	appos	6a-c,TNF
R4048	T4999	T4998	punct	),6a-c
R4049	T5000	T4977	punct	.,reduced
R4050	T5001	T5002	nsubj	This,prompted
R4051	T5002	T5002	ROOT	prompted,prompted
R4052	T5003	T5002	dobj	us,prompted
R4053	T5004	T5005	aux	to,test
R4054	T5005	T5002	xcomp	test,prompted
R4055	T5006	T5007	det	the,effect
R4056	T5007	T5005	dobj	effect,test
R4057	T5008	T5007	prep	of,effect
R4058	T5009	T5010	compound	JNK,inhibition
R4059	T5010	T5008	pobj	inhibition,of
R4060	T5011	T5010	prep	on,inhibition
R4061	T5012	T5014	amod	PMA-induced,expression
R4062	T5013	T5014	compound	cytokine,expression
R4063	T5014	T5011	pobj	expression,on
R4064	T5015	T5002	punct	.,prompted
R4065	T5016	T5018	nsubjpass	JNK,involved
R4066	T5017	T5018	auxpass	is,involved
R4067	T5018	T5018	ROOT	involved,involved
R4068	T5019	T5018	prep	in,involved
R4069	T5020	T5021	det	the,regulation
R4070	T5021	T5019	pobj	regulation,in
R4071	T5022	T5021	prep	of,regulation
R4072	T5023	T5024	det	a,multitude
R4073	T5024	T5022	pobj	multitude,of
R4074	T5025	T5024	prep	of,multitude
R4075	T5026	T5028	amod	different,factors
R4076	T5027	T5028	compound	transcription,factors
R4077	T5028	T5025	pobj	factors,of
R4078	T5029	T5028	punct	",",factors
R4079	T5030	T5028	prep	including,factors
R4080	T5031	T5032	det	the,phosphorylation
R4081	T5032	T5030	pobj	phosphorylation,including
R4082	T5033	T5032	cc	and,phosphorylation
R4083	T5034	T5032	conj	activation,phosphorylation
R4084	T5035	T5034	prep	of,activation
R4085	T5036	T5035	pobj	c-Jun,of
R4086	T5037	T5036	punct	",",c-Jun
R4087	T5038	T5036	conj	c-Fos,c-Jun
R4088	T5039	T5038	cc	and,c-Fos
R4089	T5040	T5038	conj	p53,c-Fos
R4090	T5041	T5018	punct	",",involved
R4091	T5042	T5018	advcl	leading,involved
R4092	T5043	T5042	prep	to,leading
R4093	T5044	T5045	amod	cellular,apoptosis
R4094	T5045	T5043	pobj	apoptosis,to
R4095	T5046	T5043	pobj	[,to
R4096	T5047	T5048	nummod	26,]
R4097	T5048	T5046	dobj	],[
R4098	T5049	T5018	punct	.,involved
R4099	T5050	T5055	nsubj	Inhibition,resulted
R4100	T5051	T5050	prep	of,Inhibition
R4101	T5052	T5054	det	the,pathways
R4102	T5053	T5054	compound	JNK,pathways
R4103	T5054	T5051	pobj	pathways,of
R4104	T5055	T5055	ROOT	resulted,resulted
R4105	T5056	T5055	prep	in,resulted
R4106	T5057	T5058	det	a,down-regulation
R4107	T5058	T5056	pobj	down-regulation,in
R4108	T5059	T5058	prep	of,down-regulation
R4109	T5060	T5061	det	both,CXCL8
R4110	T5061	T5059	pobj	CXCL8,of
R4111	T5062	T5061	cc	and,CXCL8
R4112	T5063	T5061	conj	IL-6,CXCL8
R4113	T5064	T5055	punct	",",resulted
R4114	T5065	T5070	mark	while,observed
R4115	T5066	T5068	det	no,effect
R4116	T5067	T5068	amod	clear,effect
R4117	T5068	T5070	nsubjpass	effect,observed
R4118	T5069	T5070	auxpass	was,observed
R4119	T5070	T5055	advcl	observed,resulted
R4120	T5071	T5070	prep	on,observed
R4121	T5072	T5073	compound	TNF,expression
R4122	T5073	T5071	pobj	expression,on
R4123	T5074	T5075	punct	(,figure
R4124	T5075	T5073	appos	figure,expression
R4125	T5076	T5075	amod	6a-c,figure
R4126	T5077	T5070	punct	),observed
R4127	T5078	T5055	punct	.,resulted
R4128	T5079	T5089	nsubj	Analysis,showed
R4129	T5080	T5079	prep	of,Analysis
R4130	T5081	T5082	compound	mRNA,levels
R4131	T5082	T5080	pobj	levels,of
R4132	T5083	T5079	acl	using,Analysis
R4133	T5084	T5083	dobj	RT-qPCR,using
R4134	T5085	T5084	punct	(,RT-qPCR
R4135	T5086	T5084	appos	table,RT-qPCR
R4136	T5087	T5086	nummod	2,table
R4137	T5088	T5084	punct	),RT-qPCR
R4138	T5089	T5089	ROOT	showed,showed
R4139	T5090	T5092	mark	that,induced
R4140	T5091	T5092	nsubj	PMA,induced
R4141	T5092	T5089	ccomp	induced,showed
R4142	T5093	T5094	preconj	both,il-6
R4143	T5094	T5092	dobj	il-6,induced
R4144	T5095	T5094	cc	and,il-6
R4145	T5096	T5094	conj	cxcl8,il-6
R4146	T5097	T5094	appos	mRNA,il-6
R4147	T5098	T5099	punct	(,5.1-fold
R4148	T5099	T5097	appos	5.1-fold,mRNA
R4149	T5100	T5099	cc	and,5.1-fold
R4150	T5101	T5102	nummod	111.8,fold
R4151	T5102	T5099	conj	fold,5.1-fold
R4152	T5103	T5102	advmod	respectively,fold
R4153	T5104	T5099	punct	),5.1-fold
R4154	T5105	T5089	punct	.,showed
R4155	T5106	T5116	nsubj	Addition,reduced
R4156	T5107	T5106	prep	of,Addition
R4157	T5108	T5111	det	the,NAI
R4158	T5109	T5111	amod	NF-κB,NAI
R4159	T5110	T5111	compound	inhibitor,NAI
R4160	T5111	T5107	pobj	NAI,of
R4161	T5112	T5111	cc	and,NAI
R4162	T5113	T5115	det	the,inhibitor
R4163	T5114	T5115	compound	JNK,inhibitor
R4164	T5115	T5111	conj	inhibitor,NAI
R4165	T5116	T5116	ROOT	reduced,reduced
R4166	T5117	T5119	det	the,expression
R4167	T5118	T5119	amod	il-6,expression
R4168	T5119	T5116	dobj	expression,reduced
R4169	T5120	T5119	prep	below,expression
R4170	T5121	T5122	amod	basal,levels
R4171	T5122	T5120	pobj	levels,below
R4172	T5123	T5116	punct	.,reduced
R4173	T5124	T5139	prep	In,remained
R4174	T5125	T5124	pobj	contrast,In
R4175	T5126	T5139	punct	",",remained
R4176	T5127	T5132	mark	while,suppressed
R4177	T5128	T5130	det	the,levels
R4178	T5129	T5130	amod	cxcl8,levels
R4179	T5130	T5132	nsubjpass	levels,suppressed
R4180	T5131	T5132	auxpass	were,suppressed
R4181	T5132	T5139	advcl	suppressed,remained
R4182	T5133	T5132	agent	by,suppressed
R4183	T5134	T5136	det	the,treatments
R4184	T5135	T5136	amod	same,treatments
R4185	T5136	T5133	pobj	treatments,by
R4186	T5137	T5138	det	the,levels
R4187	T5138	T5139	nsubj	levels,remained
R4188	T5139	T5139	ROOT	remained,remained
R4189	T5140	T5139	acomp	elevated,remained
R4190	T5141	T5140	prep	above,elevated
R4191	T5142	T5143	amod	basal,level
R4192	T5143	T5141	pobj	level,above
R4193	T5144	T5139	punct	.,remained
R12889	T15876	T15876	ROOT	Inhibition,Inhibition
R12890	T15877	T15876	prep	of,Inhibition
R12891	T15878	T15879	amod	NF-κB,activity
R12892	T15879	T15877	pobj	activity,of
R12893	T15880	T15879	prep	by,activity
R12894	T15881	T15880	pobj	NAI,by
R12895	T15882	T15876	punct	.,Inhibition
R12896	T15883	T15884	compound	Jurkat,T-cells
R12897	T15884	T15886	nsubjpass	T-cells,transfected
R12898	T15885	T15886	auxpass	were,transfected
R12899	T15886	T15886	ROOT	transfected,transfected
R12900	T15887	T15886	prep	with,transfected
R12901	T15888	T15889	compound	luciferase,reporter
R12902	T15889	T15890	compound	reporter,plasmids
R12903	T15890	T15887	pobj	plasmids,with
R12904	T15891	T15890	acl	containing,plasmids
R12905	T15892	T15893	preconj	either,NF-κB
R12906	T15893	T15897	nmod	NF-κB,elements
R12907	T15894	T15893	cc	or,NF-κB
R12908	T15895	T15893	conj	AP-1,NF-κB
R12909	T15896	T15897	amod	cis-acting,elements
R12910	T15897	T15891	dobj	elements,containing
R12911	T15898	T15886	punct	.,transfected
R12912	T15899	T15900	det	The,cells
R12913	T15900	T15902	nsubjpass	cells,incubated
R12914	T15901	T15902	auxpass	were,incubated
R12915	T15902	T15902	ROOT	incubated,incubated
R12916	T15903	T15902	prep	with,incubated
R12917	T15904	T15906	amod	NF-κB,inhibitor
R12918	T15905	T15906	compound	activation,inhibitor
R12919	T15906	T15903	pobj	inhibitor,with
R12920	T15907	T15906	punct	(,inhibitor
R12921	T15908	T15906	appos	NAI,inhibitor
R12922	T15909	T15906	punct	),inhibitor
R12923	T15910	T15902	prep	for,incubated
R12924	T15911	T15912	nummod	1,h
R12925	T15912	T15910	pobj	h,for
R12926	T15913	T15912	acl	followed,h
R12927	T15914	T15913	agent	by,followed
R12928	T15915	T15914	pobj	stimulation,by
R12929	T15916	T15913	prep	with,followed
R12930	T15917	T15916	pobj	PMA,with
R12931	T15918	T15920	punct	(,nM
R12932	T15919	T15920	nummod	162,nM
R12933	T15920	T15929	nmod	nM,coli
R12934	T15921	T15920	punct	",",nM
R12935	T15922	T15920	conj	A,nM
R12936	T15923	T15922	cc	and,A
R12937	T15924	T15922	conj	C,A
R12938	T15925	T15924	punct	),C
R12939	T15926	T15922	cc	or,A
R12940	T15927	T15929	compound	HK,coli
R12941	T15928	T15929	compound	E.,coli
R12942	T15929	T15940	meta	coli,for
R12943	T15930	T15929	punct	(,coli
R12944	T15931	T15929	appos	5,coli
R12945	T15932	T15934	nummod	×,CFU/ml
R12946	T15933	T15934	nummod	107,CFU/ml
R12947	T15934	T15929	appos	CFU/ml,coli
R12948	T15935	T15934	punct	",",CFU/ml
R12949	T15936	T15934	conj	B,CFU/ml
R12950	T15937	T15936	cc	and,B
R12951	T15938	T15936	conj	D,B
R12952	T15939	T15929	punct	),coli
R12953	T15940	T15913	prep	for,followed
R12954	T15941	T15942	nummod	24,h.
R12955	T15942	T15940	pobj	h.,for
R12956	T15943	T15944	punct	(,A
R12957	T15944	T15942	appos	A,h.
R12958	T15945	T15948	punct	",",NF-κB
R12959	T15946	T15948	nmod	B,NF-κB
R12960	T15947	T15948	punct	),NF-κB
R12961	T15948	T15944	appos	NF-κB,A
R12962	T15949	T15948	punct	",",NF-κB
R12963	T15950	T15948	cc	but,NF-κB
R12964	T15951	T15953	neg	not,C
R12965	T15952	T15953	punct	(,C
R12966	T15953	T15948	conj	C,NF-κB
R12967	T15954	T15953	punct	",",C
R12968	T15955	T15953	conj	D,C
R12969	T15956	T15953	punct	),C
R12970	T15957	T15959	nsubjpass	AP-1,inhibited
R12971	T15958	T15959	auxpass	was,inhibited
R12972	T15959	T15902	conj	inhibited,incubated
R12973	T15960	T15959	punct	.,inhibited
R12974	T15961	T15962	compound	Statistical,significance
R12975	T15962	T15973	nsubjpass	significance,determined
R12976	T15963	T15962	prep	from,significance
R12977	T15964	T15966	det	the,control
R12978	T15965	T15966	amod	positive,control
R12979	T15966	T15963	pobj	control,from
R12980	T15967	T15966	punct	(,control
R12981	T15968	T15970	compound	PMA/HK,coli
R12982	T15969	T15970	compound	E.,coli
R12983	T15970	T15966	appos	coli,control
R12984	T15971	T15966	punct	),control
R12985	T15972	T15973	auxpass	was,determined
R12986	T15973	T15973	ROOT	determined,determined
R12987	T15974	T15973	advcl	using,determined
R12988	T15975	T15977	poss	Student,t-test
R12989	T15976	T15975	case	's,Student
R12990	T15977	T15974	dobj	t-test,using
R12991	T15978	T15973	punct	.,determined
R12992	T15979	T15982	punct	(,4
R12993	T15980	T15982	advmod	n,4
R12994	T15981	T15982	punct	=,4
R12995	T15982	T15987	meta	4,set
R12996	T15983	T15982	punct	),4
R12997	T15984	T15982	punct	.,4
R12998	T15985	T15987	nsubjpass	Controls,set
R12999	T15986	T15987	auxpass	were,set
R13000	T15987	T15987	ROOT	set,set
R13001	T15988	T15987	prep	to,set
R13002	T15989	T15988	pobj	1,to
R13003	T15990	T15987	punct	.,set
R13146	T16168	T16168	ROOT	Involvement,Involvement
R13147	T16169	T16168	prep	of,Involvement
R13148	T16170	T16169	pobj	NF-κB,of
R13149	T16171	T16168	prep	in,Involvement
R13150	T16172	T16173	compound	cytokine,regulation
R13151	T16173	T16171	pobj	regulation,in
R13152	T16174	T16168	punct	.,Involvement
R13153	T16175	T16176	amod	Cytokine/chemokine,levels
R13154	T16176	T16178	nsubjpass	levels,determined
R13155	T16177	T16178	auxpass	were,determined
R13156	T16178	T16178	ROOT	determined,determined
R13157	T16179	T16178	advcl	using,determined
R13158	T16180	T16179	dobj	ELISA,using
R13159	T16181	T16178	prep	following,determined
R13160	T16182	T16181	pobj	incubation,following
R13161	T16183	T16182	prep	of,incubation
R13162	T16184	T16185	compound	Jurkat,T-cells
R13163	T16185	T16183	pobj	T-cells,of
R13164	T16186	T16182	prep	with,incubation
R13165	T16187	T16186	pobj	NAI,with
R13166	T16188	T16190	punct	(,h
R13167	T16189	T16190	nummod	1,h
R13168	T16190	T16187	appos	h,NAI
R13169	T16191	T16190	punct	),h
R13170	T16192	T16190	cc	and,h
R13171	T16193	T16190	conj	stimulation,h
R13172	T16194	T16196	punct	(,h
R13173	T16195	T16196	nummod	24,h
R13174	T16196	T16190	appos	h,h
R13175	T16197	T16190	punct	),h
R13176	T16198	T16178	punct	.,determined
R13177	T16199	T16206	punct	(,inhibited
R13178	T16200	T16203	nmod	A,expression
R13179	T16201	T16200	punct	),A
R13180	T16202	T16203	compound	CXCL8,expression
R13181	T16203	T16206	nsubjpass	expression,inhibited
R13182	T16204	T16206	auxpass	was,inhibited
R13183	T16205	T16206	advmod	partially,inhibited
R13184	T16206	T16233	advcl	inhibited,indicates
R13185	T16207	T16206	prep	following,inhibited
R13186	T16208	T16209	compound	PMA,stimulation
R13187	T16209	T16207	pobj	stimulation,following
R13188	T16210	T16212	punct	(,bars
R13189	T16211	T16212	amod	grey,bars
R13190	T16212	T16209	appos	bars,stimulation
R13191	T16213	T16206	punct	),inhibited
R13192	T16214	T16206	punct	",",inhibited
R13193	T16215	T16220	mark	whereas,altered
R13194	T16216	T16217	det	the,levels
R13195	T16217	T16220	nsubjpass	levels,altered
R13196	T16218	T16220	auxpass	were,altered
R13197	T16219	T16220	neg	not,altered
R13198	T16220	T16206	advcl	altered,inhibited
R13199	T16221	T16220	prep	following,altered
R13200	T16222	T16221	pobj	stimulation,following
R13201	T16223	T16222	prep	with,stimulation
R13202	T16224	T16226	compound	HK,coli
R13203	T16225	T16226	compound	E.,coli
R13204	T16226	T16223	pobj	coli,with
R13205	T16227	T16226	punct	(,coli
R13206	T16228	T16229	amod	black,bars
R13207	T16229	T16226	appos	bars,coli
R13208	T16230	T16226	punct	),coli
R13209	T16231	T16233	punct	",",indicates
R13210	T16232	T16233	nsubj	this,indicates
R13211	T16233	T16233	ROOT	indicates,indicates
R13212	T16234	T16235	det	an,induction
R13213	T16235	T16233	dobj	induction,indicates
R13214	T16236	T16237	advmod	mainly,regulated
R13215	T16237	T16235	acl	regulated,induction
R13216	T16238	T16237	agent	by,regulated
R13217	T16239	T16238	pobj	AP-1,by
R13218	T16240	T16233	punct	.,indicates
R13219	T16241	T16248	punct	(,affected
R13220	T16242	T16245	nmod	B,expression
R13221	T16243	T16242	punct	),B
R13222	T16244	T16245	compound	TNF,expression
R13223	T16245	T16248	nsubjpass	expression,affected
R13224	T16246	T16248	auxpass	was,affected
R13225	T16247	T16248	neg	not,affected
R13226	T16248	T16248	ROOT	affected,affected
R13227	T16249	T16248	agent	by,affected
R13228	T16250	T16249	pobj	NAI,by
R13229	T16251	T16248	punct	.,affected
R13230	T16252	T16253	punct	(,C
R13231	T16253	T16253	ROOT	C,C
R13232	T16254	T16253	punct	),C
R13233	T16255	T16256	compound	IL-6,release
R13234	T16256	T16259	nsubjpass	release,inhibited
R13235	T16257	T16259	auxpass	was,inhibited
R13236	T16258	T16259	advmod	completely,inhibited
R13237	T16259	T16259	ROOT	inhibited,inhibited
R13238	T16260	T16259	agent	by,inhibited
R13239	T16261	T16260	pobj	NAI,by
R13240	T16262	T16259	prep	following,inhibited
R13241	T16263	T16264	compound	PMA,exposure
R13242	T16264	T16262	pobj	exposure,following
R13243	T16265	T16259	punct	",",inhibited
R13244	T16266	T16259	advcl	indicating,inhibited
R13245	T16267	T16266	dobj	regulation,indicating
R13246	T16268	T16266	prep	through,indicating
R13247	T16269	T16268	pobj	NF-κB,through
R13248	T16270	T16275	mark	since,increased
R13249	T16271	T16272	compound	IL-6,expression
R13250	T16272	T16275	nsubjpass	expression,increased
R13251	T16273	T16275	auxpass	was,increased
R13252	T16274	T16275	advmod	significantly,increased
R13253	T16275	T16266	advcl	increased,indicating
R13254	T16276	T16275	prep	in,increased
R13255	T16277	T16276	pobj	response,in
R13256	T16278	T16277	prep	to,response
R13257	T16279	T16281	compound	HK,coli
R13258	T16280	T16281	compound	E.,coli
R13259	T16281	T16278	pobj	coli,to
R13260	T16282	T16275	prep	than,increased
R13261	T16283	T16282	pobj	PMA,than
R13262	T16284	T16259	punct	.,inhibited
R13263	T16285	T16286	compound	Statistical,significance
R13264	T16286	T16297	nsubjpass	significance,determined
R13265	T16287	T16286	prep	from,significance
R13266	T16288	T16290	det	the,control
R13267	T16289	T16290	amod	positive,control
R13268	T16290	T16287	pobj	control,from
R13269	T16291	T16290	punct	(,control
R13270	T16292	T16294	compound	PMA/HK,coli
R13271	T16293	T16294	compound	E.,coli
R13272	T16294	T16290	appos	coli,control
R13273	T16295	T16290	punct	),control
R13274	T16296	T16297	auxpass	was,determined
R13275	T16297	T16297	ROOT	determined,determined
R13276	T16298	T16297	advcl	using,determined
R13277	T16299	T16301	poss	Student,t-test
R13278	T16300	T16299	case	's,Student
R13279	T16301	T16298	dobj	t-test,using
R13280	T16302	T16297	punct	.,determined
R13281	T16303	T16306	punct	(,3
R13282	T16304	T16306	advmod	n,3
R13283	T16305	T16306	punct	=,3
R13284	T16306	T16306	ROOT	3,3
R13285	T16307	T16306	punct	),3
R13286	T16308	T16306	punct	.,3
R13365	T16439	T16439	ROOT	Involvement,Involvement
R13366	T16440	T16439	prep	of,Involvement
R13367	T16441	T16440	pobj	PKC,of
R13368	T16442	T16441	cc	and,PKC
R13369	T16443	T16441	conj	JNK,PKC
R13370	T16444	T16439	prep	in,Involvement
R13371	T16445	T16446	amod	cytokine,expression
R13372	T16446	T16444	pobj	expression,in
R13373	T16447	T16439	punct	.,Involvement
R13374	T16448	T16449	compound	Jurkat,T-cells
R13375	T16449	T16451	nsubjpass	T-cells,incubated
R13376	T16450	T16451	auxpass	were,incubated
R13377	T16451	T16451	ROOT	incubated,incubated
R13378	T16452	T16451	prep	with,incubated
R13379	T16453	T16452	pobj	PKC,with
R13380	T16454	T16451	punct	-,incubated
R13381	T16455	T16451	cc	and,incubated
R13382	T16456	T16457	compound	JNK,inhibitors
R13383	T16457	T16479	nsubjpass	inhibitors,inhibited
R13384	T16458	T16457	prep	for,inhibitors
R13385	T16459	T16460	nummod	1,h
R13386	T16460	T16458	pobj	h,for
R13387	T16461	T16457	acl	followed,inhibitors
R13388	T16462	T16461	agent	by,followed
R13389	T16463	T16462	pobj	stimulation,by
R13390	T16464	T16461	prep	with,followed
R13391	T16465	T16464	pobj	PMA,with
R13392	T16466	T16465	punct	(,PMA
R13393	T16467	T16468	nummod	162,nM
R13394	T16468	T16465	appos	nM,PMA
R13395	T16469	T16465	punct	),PMA
R13396	T16470	T16461	prep	for,followed
R13397	T16471	T16472	nummod	24,h.
R13398	T16472	T16470	pobj	h.,for
R13399	T16473	T16474	punct	(,A
R13400	T16474	T16477	nmod	A,expression
R13401	T16475	T16474	punct	),A
R13402	T16476	T16477	compound	CXCL8,expression
R13403	T16477	T16479	nsubjpass	expression,inhibited
R13404	T16478	T16479	auxpass	was,inhibited
R13405	T16479	T16451	conj	inhibited,incubated
R13406	T16480	T16479	prep	in,inhibited
R13407	T16481	T16483	det	a,manner
R13408	T16482	T16483	amod	dose-dependent,manner
R13409	T16483	T16480	pobj	manner,in
R13410	T16484	T16479	agent	by,inhibited
R13411	T16485	T16486	det	both,inhibitors
R13412	T16486	T16484	pobj	inhibitors,by
R13413	T16487	T16479	punct	.,inhibited
R13414	T16488	T16491	punct	(,JNK-I
R13415	T16489	T16491	nmod	B,JNK-I
R13416	T16490	T16491	punct	),JNK-I
R13417	T16491	T16492	nsubj	JNK-I,revealed
R13418	T16492	T16492	ROOT	revealed,revealed
R13419	T16493	T16496	det	a,effect
R13420	T16494	T16496	amod	stronger,effect
R13421	T16495	T16496	compound	inhibitory,effect
R13422	T16496	T16492	dobj	effect,revealed
R13423	T16497	T16496	prep	on,effect
R13424	T16498	T16499	amod	IL-6,expression
R13425	T16499	T16497	pobj	expression,on
R13426	T16500	T16499	prep	than,expression
R13427	T16501	T16502	det	the,PKC-I
R13428	T16502	T16500	pobj	PKC-I,than
R13429	T16503	T16492	punct	.,revealed
R13430	T16504	T16511	punct	(,affected
R13431	T16505	T16508	nmod	C,expression
R13432	T16506	T16505	punct	),C
R13433	T16507	T16508	compound	TNF,expression
R13434	T16508	T16511	nsubjpass	expression,affected
R13435	T16509	T16511	auxpass	was,affected
R13436	T16510	T16511	neg	not,affected
R13437	T16511	T16511	ROOT	affected,affected
R13438	T16512	T16511	agent	by,affected
R13439	T16513	T16514	det	either,inhibitor
R13440	T16514	T16512	pobj	inhibitor,by
R13441	T16515	T16511	punct	.,affected
R13442	T16516	T16517	compound	Statistical,significance
R13443	T16517	T16526	nsubjpass	significance,determined
R13444	T16518	T16517	prep	from,significance
R13445	T16519	T16521	det	the,control
R13446	T16520	T16521	amod	positive,control
R13447	T16521	T16518	pobj	control,from
R13448	T16522	T16521	punct	(,control
R13449	T16523	T16521	appos	PMA,control
R13450	T16524	T16521	punct	),control
R13451	T16525	T16526	auxpass	was,determined
R13452	T16526	T16526	ROOT	determined,determined
R13453	T16527	T16526	advcl	using,determined
R13454	T16528	T16530	poss	Student,t-test
R13455	T16529	T16528	case	's,Student
R13456	T16530	T16527	dobj	t-test,using
R13457	T16531	T16526	punct	.,determined
R13458	T16532	T16535	punct	(,3
R13459	T16533	T16534	advmod	n,=
R13460	T16534	T16535	punct	=,3
R13461	T16535	T16535	ROOT	3,3
R13462	T16536	T16535	punct	),3
R13463	T16537	T16535	punct	.,3
R13878	T17047	T17048	compound	Jurkat,T-cells
R13879	T17048	T17050	nsubjpass	T-cells,treated
R13880	T17049	T17050	auxpass	were,treated
R13881	T17050	T17050	ROOT	treated,treated
R13882	T17051	T17050	prep	with,treated
R13883	T17052	T17054	nummod	10,NAI
R13884	T17053	T17054	compound	nM,NAI
R13885	T17054	T17051	pobj	NAI,with
R13886	T17055	T17054	punct	",",NAI
R13891	T17060	T17061	compound	nM,PKC-I
R13892	T17061	T17054	appos	PKC-I,NAI
R13893	T17062	T17050	prep	for,treated
R13894	T17063	T17064	nummod	2,h
R13895	T17064	T17062	pobj	h,for
R13896	T17065	T17050	advcl	followed,treated
R13897	T17066	T17065	agent	by,followed
R13898	T17067	T17066	pobj	induction,by
R13899	T17068	T17067	prep	with,induction
R13900	T17069	T17071	nummod	162,PMA
R13901	T17070	T17071	compound	nM,PMA
R13902	T17071	T17068	pobj	PMA,with
R13903	T17072	T17065	prep	for,followed
R13904	T17073	T17074	nummod	24,h.
R13905	T17074	T17072	pobj	h.,for
R3853	T4804	T4800	ccomp	down-regulated,showed
R13887	T17056	T17058	nummod	10,JNK-I
R13888	T17057	T17058	compound	μM,JNK-I
R13889	T17058	T17054	appos	JNK-I,NAI
R13890	T17059	T17061	compound	or10,PKC-I

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T5548	12-34	http://purl.obolibrary.org/obo/GO_0042089	denotes	induction of cytokines
T5549	114-124	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T5550	874-884	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T5551	2630-2640	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T5552	2848-2858	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T5553	151-167	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T5554	240-256	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T5555	151-177	http://purl.obolibrary.org/obo/GO_1903721	denotes	NF-κB activation inhibitor
T5556	869-884	http://purl.obolibrary.org/obo/GO_0032675	denotes	IL-6 regulation
T5557	869-884	http://purl.obolibrary.org/obo/GO_0045408	denotes	IL-6 regulation
T5558	2313-2316	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T5559	2407-2410	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T5560	2556-2559	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5561	2607-2610	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5562	2816-2819	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5563	3132-3135	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5564	2669-2682	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T5565	2706-2721	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5569	2782-2791	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T5570	2981-2983	http://purl.obolibrary.org/obo/GO_0003964	denotes	RT
T5571	3104-3119	http://purl.obolibrary.org/obo/GO_0032088	denotes	NF-κB inhibitor
T5572	3104-3119	http://purl.obolibrary.org/obo/GO_0007252	denotes	NF-κB inhibitor
T16108	1082-1098	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T16109	1082-1108	http://purl.obolibrary.org/obo/GO_1903721	denotes	NF-κB activation inhibitor
T16319	1456-1466	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T16320	1954-1964	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T16636	3342-3345	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T16637	3413-3416	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T16638	3655-3658	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T16639	3350-3353	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16640	3422-3425	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16641	3583-3586	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T17104	3883-3886	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T17105	3897-3900	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T5566	2706-2736	http://purl.obolibrary.org/obo/GO_0042327	denotes	phosphorylation and activation
T5567	2773-2781	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T5568	2782-2791	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T5573	739-743	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T5574	869-873	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T5575	2489-2493	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T5576	2877-2881	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T5577	2313-2316	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T5578	2407-2410	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T5579	2556-2559	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5580	2607-2610	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5581	2816-2819	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5582	3132-3135	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5583	2981-2983	http://purl.obolibrary.org/obo/GO_0003964	denotes	RT
T16321	1874-1878	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T16322	1985-1989	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T16642	3342-3345	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T16643	3413-3416	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T16644	3655-3658	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC
T16645	3350-3353	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16646	3422-3425	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16647	3583-3586	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16648	3630-3634	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T17106	3883-3886	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T17107	3897-3900	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKC

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T5584	137-142	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5585	351-356	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5586	678-683	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5587	2302-2307	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16110	942-947	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16111	1056-1061	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16323	1555-1560	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16649	3387-3392	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T17108	3842-3847	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T4753	0-52	Sentence	denotes	Cooperative induction of cytokines by AP-1 and NF-κB
T4754	53-184	Sentence	denotes	To further characterize the involvement of NF-κB in cytokine regulation, we treated cells with an NF-κB activation inhibitor (NAI).
T4755	185-329	Sentence	denotes	The results showed that NAI selectively down-regulated NF-κB activation (figures 4a and 4b) and did not alter AP-1 activity (figures 4c and 4d).
T4756	330-511	Sentence	denotes	Exposure of Jurkat T-cells to NAI resulted in a modest reduction of CXCL8 following PMA exposure, while it did not alter the CXCL8 release following HK E. coli exposure (figure 5a).
T4757	512-684	Sentence	denotes	NAI did not affect TNF expression (figure 5b) indicating that NF-κB is not the main regulator of CXCL8 or TNF following either PMA or HK E. coli exposure in Jurkat T-cells.
T4758	685-885	Sentence	denotes	In contrast, NAI resulted in a complete inhibition of IL-6 following PMA exposure and a 45% inhibition following HK E. coli exposure (figure 5c), suggesting an involvement of NF-κB in IL-6 regulation.
T4759	2183-2392	Sentence	denotes	Ca2+ was observed to increase AP-1 activity (figure 1c) and reduce NF-κB activity (figure 2e); therefore, we exposed T-cells to a PKC inhibitor together with PMA to determine its effect on cytokine expression.
T4760	2393-2516	Sentence	denotes	Inhibition of PKC reduced CXCL8 release from 7 ng/ml to 3 ng/ml while it had a modest effect on IL-6 and TNF (figure 6a-c).
T4761	2517-2606	Sentence	denotes	This prompted us to test the effect of JNK inhibition on PMA-induced cytokine expression.
T4762	2607-2797	Sentence	denotes	JNK is involved in the regulation of a multitude of different transcription factors, including the phosphorylation and activation of c-Jun, c-Fos and p53, leading to cellular apoptosis [26].
T4763	2798-2950	Sentence	denotes	Inhibition of the JNK pathways resulted in a down-regulation of both CXCL8 and IL-6, while no clear effect was observed on TNF expression (figure 6a-c).
T4764	2951-3087	Sentence	denotes	Analysis of mRNA levels using RT-qPCR (table 2) showed that PMA induced both il-6 and cxcl8 mRNA (5.1-fold and 111.8 fold respectively).
T4765	3088-3193	Sentence	denotes	Addition of the NF-κB inhibitor NAI and the JNK inhibitor reduced the il-6 expression below basal levels.
T4766	3194-3316	Sentence	denotes	In contrast, while the cxcl8 levels were suppressed by the same treatments the levels remained elevated above basal level.
T15871	896-932	Sentence	denotes	Inhibition of NF-κB activity by NAI.
T15872	933-1051	Sentence	denotes	Jurkat T-cells were transfected with luciferase reporter plasmids containing either NF-κB or AP-1 cis-acting elements.
T15873	1052-1272	Sentence	denotes	The cells were incubated with NF-κB activation inhibitor (NAI) for 1 h followed by stimulation with PMA (162 nM, A and C) or HK E. coli (5 × 107 CFU/ml, B and D) for 24 h. (A, B) NF-κB, but not (C, D) AP-1 was inhibited.
T15874	1273-1388	Sentence	denotes	Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 4).
T15875	1389-1412	Sentence	denotes	Controls were set to 1.
T16165	1423-1467	Sentence	denotes	Involvement of NF-κB in cytokine regulation.
T16166	1468-2064	Sentence	denotes	Cytokine/chemokine levels were determined using ELISA following incubation of Jurkat T-cells with NAI (1 h) and stimulation (24 h). (A) CXCL8 expression was partially inhibited following PMA stimulation (grey bars), whereas the levels were not altered following stimulation with HK E. coli (black bars), this indicates an induction mainly regulated by AP-1. (B) TNF expression was not affected by NAI. (C) IL-6 release was completely inhibited by NAI following PMA exposure, indicating regulation through NF-κB since IL-6 expression was significantly increased in response to HK E. coli than PMA.
T16167	2065-2180	Sentence	denotes	Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 3).
T16436	3327-3377	Sentence	denotes	Involvement of PKC and JNK in cytokine expression.
T16437	3378-3718	Sentence	denotes	Jurkat T-cells were incubated with PKC- and JNK inhibitors for 1 h followed by stimulation with PMA (162 nM) for 24 h. (A) CXCL8 expression was inhibited in a dose-dependent manner by both inhibitors. (B) JNK-I revealed a stronger inhibitory effect on IL-6 expression than the PKC-I. (C) TNF expression was not affected by either inhibitor.
T16438	3719-3823	Sentence	denotes	Statistical significance from the positive control (PMA) was determined using Student's t-test. (n = 3).
T17046	3833-3958	Sentence	denotes	Jurkat T-cells were treated with 10 nM NAI, 10 μM JNK-I or10 nM PKC-I for 2 h followed by induction with 162 nM PMA for 24 h.
T81	0-52	Sentence	denotes	Cooperative induction of cytokines by AP-1 and NF-κB
T82	53-184	Sentence	denotes	To further characterize the involvement of NF-κB in cytokine regulation, we treated cells with an NF-κB activation inhibitor (NAI).
T83	185-329	Sentence	denotes	The results showed that NAI selectively down-regulated NF-κB activation (figures 4a and 4b) and did not alter AP-1 activity (figures 4c and 4d).
T84	330-511	Sentence	denotes	Exposure of Jurkat T-cells to NAI resulted in a modest reduction of CXCL8 following PMA exposure, while it did not alter the CXCL8 release following HK E. coli exposure (figure 5a).
T85	512-684	Sentence	denotes	NAI did not affect TNF expression (figure 5b) indicating that NF-κB is not the main regulator of CXCL8 or TNF following either PMA or HK E. coli exposure in Jurkat T-cells.
T86	685-885	Sentence	denotes	In contrast, NAI resulted in a complete inhibition of IL-6 following PMA exposure and a 45% inhibition following HK E. coli exposure (figure 5c), suggesting an involvement of NF-κB in IL-6 regulation.
T87	886-932	Sentence	denotes	Figure 4 Inhibition of NF-κB activity by NAI.
T88	933-1051	Sentence	denotes	Jurkat T-cells were transfected with luciferase reporter plasmids containing either NF-κB or AP-1 cis-acting elements.
T89	1052-1272	Sentence	denotes	The cells were incubated with NF-κB activation inhibitor (NAI) for 1 h followed by stimulation with PMA (162 nM, A and C) or HK E. coli (5 × 107 CFU/ml, B and D) for 24 h. (A, B) NF-κB, but not (C, D) AP-1 was inhibited.
T90	1273-1388	Sentence	denotes	Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 4).
T91	1389-1412	Sentence	denotes	Controls were set to 1.
T92	1413-1467	Sentence	denotes	Figure 5 Involvement of NF-κB in cytokine regulation.
T93	1468-2064	Sentence	denotes	Cytokine/chemokine levels were determined using ELISA following incubation of Jurkat T-cells with NAI (1 h) and stimulation (24 h). (A) CXCL8 expression was partially inhibited following PMA stimulation (grey bars), whereas the levels were not altered following stimulation with HK E. coli (black bars), this indicates an induction mainly regulated by AP-1. (B) TNF expression was not affected by NAI. (C) IL-6 release was completely inhibited by NAI following PMA exposure, indicating regulation through NF-κB since IL-6 expression was significantly increased in response to HK E. coli than PMA.
T94	2065-2180	Sentence	denotes	Statistical significance from the positive control (PMA/HK E. coli) was determined using Student's t-test. (n = 3).
T95	2183-2392	Sentence	denotes	Ca2+ was observed to increase AP-1 activity (figure 1c) and reduce NF-κB activity (figure 2e); therefore, we exposed T-cells to a PKC inhibitor together with PMA to determine its effect on cytokine expression.
T96	2393-2516	Sentence	denotes	Inhibition of PKC reduced CXCL8 release from 7 ng/ml to 3 ng/ml while it had a modest effect on IL-6 and TNF (figure 6a-c).
T97	2517-2606	Sentence	denotes	This prompted us to test the effect of JNK inhibition on PMA-induced cytokine expression.
T98	2607-2797	Sentence	denotes	JNK is involved in the regulation of a multitude of different transcription factors, including the phosphorylation and activation of c-Jun, c-Fos and p53, leading to cellular apoptosis [26].
T99	2798-2950	Sentence	denotes	Inhibition of the JNK pathways resulted in a down-regulation of both CXCL8 and IL-6, while no clear effect was observed on TNF expression (figure 6a-c).
T100	2951-3087	Sentence	denotes	Analysis of mRNA levels using RT-qPCR (table 2) showed that PMA induced both il-6 and cxcl8 mRNA (5.1-fold and 111.8 fold respectively).
T101	3088-3193	Sentence	denotes	Addition of the NF-κB inhibitor NAI and the JNK inhibitor reduced the il-6 expression below basal levels.
T102	3194-3316	Sentence	denotes	In contrast, while the cxcl8 levels were suppressed by the same treatments the levels remained elevated above basal level.
T103	3317-3377	Sentence	denotes	Figure 6 Involvement of PKC and JNK in cytokine expression.
T104	3378-3718	Sentence	denotes	Jurkat T-cells were incubated with PKC- and JNK inhibitors for 1 h followed by stimulation with PMA (162 nM) for 24 h. (A) CXCL8 expression was inhibited in a dose-dependent manner by both inhibitors. (B) JNK-I revealed a stronger inhibitory effect on IL-6 expression than the PKC-I. (C) TNF expression was not affected by either inhibitor.
T105	3719-3823	Sentence	denotes	Statistical significance from the positive control (PMA) was determined using Student's t-test. (n = 3).
T106	3824-3958	Sentence	denotes	Table 2 Jurkat T-cells were treated with 10 nM NAI, 10 μM JNK-I or10 nM PKC-I for 2 h followed by induction with 162 nM PMA for 24 h.
T107	3960-4005	Sentence	denotes	Gene expression was determined using RT-qPCR.
T108	4006-4048	Sentence	denotes	The Ct values were normalized against 18S.
T109	4049-4144	Sentence	denotes	Statistical significance from the positive control (PMA) was determined using Student's t-test.
T110	4145-4222	Sentence	denotes	Concentrations are given as fg/ml, values are presented as mean ± SEM, n = 3.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T5819	385-394	Negative_regulation	denotes	reduction
T5820	398-403	Protein	denotes	CXCL8
T5821	404-413	Positive_regulation	denotes	following
T5822	445-450	Regulation	denotes	alter	true
T5823	455-460	Protein	denotes	CXCL8
T5824	461-468	Localization	denotes	release
T5825	469-478	Positive_regulation	denotes	following
T5826	596-605	Regulation	denotes	regulator	true
T5827	609-614	Protein	denotes	CXCL8
T5828	622-631	Positive_regulation	denotes	following
T5829	725-735	Negative_regulation	denotes	inhibition
T5830	739-743	Protein	denotes	IL-6
T5831	744-753	Positive_regulation	denotes	following
T5832	777-787	Negative_regulation	denotes	inhibition
T5833	788-797	Positive_regulation	denotes	following
T5834	845-856	Regulation	denotes	involvement		true
T5835	869-873	Protein	denotes	IL-6
T5836	874-884	Regulation	denotes	regulation
T5837	2411-2418	Negative_regulation	denotes	reduced
T5838	2419-2424	Protein	denotes	CXCL8
T5839	2425-2432	Localization	denotes	release
T5840	2479-2485	Regulation	denotes	effect
T5841	2489-2493	Protein	denotes	IL-6
T5842	2706-2721	Phosphorylation	denotes	phosphorylation
T5843	2706-2721	Phosphorylation	denotes	phosphorylation
T5844	2706-2721	Phosphorylation	denotes	phosphorylation
T5845	2726-2736	Positive_regulation	denotes	activation
T5846	2726-2736	Positive_regulation	denotes	activation
T5847	2726-2736	Positive_regulation	denotes	activation
T5848	2740-2745	Protein	denotes	c-Jun
T5849	2747-2752	Protein	denotes	c-Fos
T5850	2757-2760	Protein	denotes	p53
T5851	2829-2837	Positive_regulation	denotes	resulted
T5852	2829-2837	Positive_regulation	denotes	resulted
T5853	2843-2858	Negative_regulation	denotes	down-regulation
T5854	2843-2858	Negative_regulation	denotes	down-regulation
T5855	2867-2872	Protein	denotes	CXCL8
T5856	2877-2881	Protein	denotes	IL-6
T5857	3015-3022	Positive_regulation	denotes	induced
T5858	3015-3022	Positive_regulation	denotes	induced
T5859	3028-3032	Protein	denotes	il-6
T5860	3037-3042	Protein	denotes	cxcl8
T5861	3043-3047	Transcription	denotes	mRNA
T5862	3043-3047	Transcription	denotes	mRNA
T5863	3146-3153	Negative_regulation	denotes	reduced
T5864	3158-3162	Protein	denotes	il-6
T5865	3163-3173	Transcription	denotes	expression
T5866	3217-3222	Protein	denotes	cxcl8
T5867	3223-3229	Transcription	denotes	levels
T5868	3235-3245	Negative_regulation	denotes	suppressed
T5869	3280-3288	Regulation	denotes	remained	true
T5870	3289-3297	Positive_regulation	denotes	elevated
T16383	1604-1609	Protein	denotes	CXCL8
T16384	1610-1620	Gene_expression	denotes	expression
T16385	1635-1644	Negative_regulation	denotes	inhibited
T16386	1712-1719	Regulation	denotes	altered	true
T16387	1790-1799	Positive_regulation	denotes	induction
T16388	1807-1816	Regulation	denotes	regulated
T16389	1874-1878	Protein	denotes	IL-6
T16390	1879-1886	Localization	denotes	release
T16391	1902-1911	Negative_regulation	denotes	inhibited
T16392	1954-1964	Regulation	denotes	regulation
T16393	1985-1989	Protein	denotes	IL-6
T16394	1990-2000	Gene_expression	denotes	expression
T16395	2019-2028	Positive_regulation	denotes	increased
T16687	3501-3506	Protein	denotes	CXCL8
T16688	3507-3517	Gene_expression	denotes	expression
T16689	3522-3531	Negative_regulation	denotes	inhibited
T16690	3542-3551	Regulation	denotes	dependent
T16691	3609-3626	Negative_regulation	denotes	inhibitory effect
T16692	3630-3634	Protein	denotes	IL-6
T16693	3635-3645	Gene_expression	denotes	expression
T16117	970-980	Protein	denotes	luciferase
R4719	T5820	T5821	themeOf	CXCL8,following
R4720	T5821	T5819	themeOf	following,reduction
R4721	T5823	T5824	themeOf	CXCL8,release
R4722	T5824	T5825	themeOf	release,following
R4723	T5825	T5822	themeOf	following,alter
R4724	T5827	T5828	themeOf	CXCL8,following
R4725	T5828	T5826	themeOf	following,regulator
R4726	T5830	T5829	themeOf	IL-6,inhibition
R4727	T5830	T5831	themeOf	IL-6,following
R4728	T5830	T5832	themeOf	IL-6,inhibition
R4729	T5830	T5833	themeOf	IL-6,following
R4730	T5835	T5836	themeOf	IL-6,regulation
R4731	T5836	T5834	themeOf	regulation,involvement
R4732	T5838	T5839	themeOf	CXCL8,release
R4733	T5839	T5837	themeOf	release,reduced
R4734	T5841	T5840	themeOf	IL-6,effect
R4735	T5848	T5844	themeOf	c-Jun,phosphorylation
R4736	T5848	T5845	themeOf	c-Jun,activation
R4737	T5849	T5842	themeOf	c-Fos,phosphorylation
R4738	T5849	T5846	themeOf	c-Fos,activation
R4739	T5850	T5843	themeOf	p53,phosphorylation
R4740	T5850	T5847	themeOf	p53,activation
R4741	T5853	T5852	themeOf	down-regulation,resulted
R4742	T5854	T5851	themeOf	down-regulation,resulted
R4743	T5855	T5854	themeOf	CXCL8,down-regulation
R4744	T5856	T5853	themeOf	IL-6,down-regulation
R4745	T5859	T5862	themeOf	il-6,mRNA
R4746	T5860	T5861	themeOf	cxcl8,mRNA
R4747	T5861	T5857	themeOf	mRNA,induced
R4748	T5862	T5858	themeOf	mRNA,induced
R4749	T5864	T5865	themeOf	il-6,expression
R4750	T5865	T5863	themeOf	expression,reduced
R4751	T5866	T5867	themeOf	cxcl8,levels
R4752	T5867	T5868	themeOf	levels,suppressed
R4753	T5867	T5870	themeOf	levels,elevated
R4754	T5870	T5869	themeOf	elevated,remained
R13331	T16383	T16384	themeOf	CXCL8,expression
R13332	T16384	T16385	themeOf	expression,inhibited
R13333	T16384	T16386	themeOf	expression,altered
R13334	T16384	T16387	themeOf	expression,induction
R13335	T16387	T16388	themeOf	induction,regulated
R13336	T16389	T16390	themeOf	IL-6,release
R13337	T16390	T16392	themeOf	release,regulation
R13338	T16390	T16391	themeOf	release,inhibited
R13339	T16393	T16394	themeOf	IL-6,expression
R13340	T16394	T16395	themeOf	expression,increased
R13584	T16687	T16688	themeOf	CXCL8,expression
R13585	T16688	T16689	themeOf	expression,inhibited
R13586	T16689	T16690	themeOf	inhibited,dependent
R13587	T16692	T16693	themeOf	IL-6,expression
R13588	T16693	T16691	themeOf	expression,inhibitory effect

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T5872	47-52	Protein	denotes	NF-κB
T5873	96-101	Protein	denotes	NF-κB
T5874	151-156	Protein	denotes	NF-κB
T5875	240-245	Protein	denotes	NF-κB
T5876	295-299	Protein	denotes	AP-1
T5877	246-256	Positive_regulation	denotes	activation
T5878	289-294	Regulation	denotes	alter
T5879	225-239	Negative_regulation	denotes	down-regulated
T5880	398-403	Protein	denotes	CXCL8
T5881	455-468	Protein	denotes	CXCL8 release
T5882	479-483	Protein	denotes	HK E
T5883	385-394	Negative_regulation	denotes	reduction
T5884	445-450	Regulation	denotes	alter
T5885	531-534	Protein	denotes	TNF
T5886	574-579	Protein	denotes	NF-κB
T5887	609-614	Protein	denotes	CXCL8
T5888	618-621	Protein	denotes	TNF
T5889	535-545	Gene_expression	denotes	expression
T5890	596-605	Regulation	denotes	regulator
T5891	524-530	Regulation	denotes	affect
T5892	739-743	Protein	denotes	IL-6
T5893	860-865	Protein	denotes	NF-κB
T5894	869-873	Protein	denotes	IL-6
T5895	725-735	Negative_regulation	denotes	inhibition
T5896	874-884	Regulation	denotes	regulation
T5897	845-856	Regulation	denotes	involvement
T5898	2213-2217	Protein	denotes	AP-1
T5899	2250-2255	Protein	denotes	NF-κB
T5900	2313-2316	Protein	denotes	PKC
T5901	2204-2212	Positive_regulation	denotes	increase
T5902	2243-2249	Negative_regulation	denotes	reduce
T5903	2317-2326	Negative_regulation	denotes	inhibitor
T5904	2407-2410	Protein	denotes	PKC
T5905	2419-2424	Protein	denotes	CXCL8
T5906	2489-2493	Protein	denotes	IL-6
T5907	2498-2501	Protein	denotes	TNF
T5908	2393-2403	Negative_regulation	denotes	Inhibition
T5909	2425-2432	Localization	denotes	release
T5910	2479-2485	Positive_regulation	denotes	effect
T5911	2479-2485	Positive_regulation	denotes	effect
T5912	2411-2418	Negative_regulation	denotes	reduced
T5913	2556-2559	Protein	denotes	JNK
T5914	2560-2570	Negative_regulation	denotes	inhibition
T5915	2546-2552	Regulation	denotes	effect
T5916	2607-2610	Protein	denotes	JNK
T5917	2740-2745	Protein	denotes	c-Jun
T5918	2747-2752	Protein	denotes	c-Fos
T5919	2757-2760	Protein	denotes	p53
T5920	2706-2721	Phosphorylation	denotes	phosphorylation
T5921	2706-2721	Phosphorylation	denotes	phosphorylation
T5922	2706-2721	Phosphorylation	denotes	phosphorylation
T5923	2726-2736	Positive_regulation	denotes	activation
T5924	2726-2736	Positive_regulation	denotes	activation
T5925	2726-2736	Positive_regulation	denotes	activation
T5926	2630-2640	Regulation	denotes	regulation
T5927	2630-2640	Regulation	denotes	regulation
T5928	2630-2640	Regulation	denotes	regulation
T5929	2630-2640	Regulation	denotes	regulation
T5930	2630-2640	Regulation	denotes	regulation
T5931	2630-2640	Regulation	denotes	regulation
T5932	2816-2819	Protein	denotes	JNK
T5933	2867-2872	Protein	denotes	CXCL8
T5934	2877-2881	Protein	denotes	IL-6
T5935	2921-2924	Protein	denotes	TNF
T5936	2798-2808	Negative_regulation	denotes	Inhibition
T5937	2843-2858	Negative_regulation	denotes	down-regulation
T5938	2843-2858	Negative_regulation	denotes	down-regulation
T5939	2925-2935	Gene_expression	denotes	expression
T5940	2829-2837	Negative_regulation	denotes	resulted
T5941	2829-2837	Negative_regulation	denotes	resulted
T5942	2898-2904	Regulation	denotes	effect
T5943	3037-3047	Protein	denotes	cxcl8 mRNA
T5944	3015-3022	Positive_regulation	denotes	induced
T5945	3104-3109	Protein	denotes	NF-κB
T5946	3132-3135	Protein	denotes	JNK
T5947	3136-3145	Negative_regulation	denotes	inhibitor
T16118	910-915	Protein	denotes	NF-κB
T16119	896-906	Negative_regulation	denotes	Inhibition
T16120	970-980	Protein	denotes	luciferase
T16121	1017-1022	Protein	denotes	NF-κB
T16122	1026-1030	Protein	denotes	AP-1
T16123	1082-1087	Protein	denotes	NF-κB
T16124	1231-1236	Protein	denotes	NF-κB
T16125	1262-1271	Negative_regulation	denotes	inhibited
T16396	1438-1443	Protein	denotes	NF-κB
T16397	1456-1466	Regulation	denotes	regulation
T16398	1604-1609	Protein	denotes	CXCL8
T16399	1747-1751	Protein	denotes	HK E
T16400	1820-1824	Protein	denotes	AP-1
T16401	1610-1620	Gene_expression	denotes	expression
T16402	1635-1644	Negative_regulation	denotes	inhibited
T16403	1830-1833	Protein	denotes	TNF
T16404	1834-1844	Gene_expression	denotes	expression
T16405	1853-1861	Regulation	denotes	affected
T16406	1973-1978	Protein	denotes	NF-κB
T16407	1985-1989	Protein	denotes	IL-6
T16408	2044-2046	Protein	denotes	HK
T16409	1990-2000	Gene_expression	denotes	expression
T16410	2019-2028	Positive_regulation	denotes	increased
T16411	1954-1964	Regulation	denotes	regulation
T16694	3342-3345	Protein	denotes	PKC
T16695	3350-3353	Protein	denotes	JNK
T16696	3413-3416	Protein	denotes	PKC
T16697	3422-3425	Protein	denotes	JNK
T16698	3426-3436	Negative_regulation	denotes	inhibitors
T16699	3426-3436	Negative_regulation	denotes	inhibitors
T16700	3501-3506	Protein	denotes	CXCL8
T16701	3507-3517	Gene_expression	denotes	expression
T16702	3522-3531	Negative_regulation	denotes	inhibited
T16703	3583-3588	Protein	denotes	JNK-I
T16704	3630-3634	Protein	denotes	IL-6
T16705	3655-3660	Protein	denotes	PKC-I
T16706	3635-3645	Gene_expression	denotes	expression
T16707	3666-3669	Protein	denotes	TNF
T16708	3670-3680	Gene_expression	denotes	expression
T16709	3689-3697	Regulation	denotes	affected
T5871	38-42	Protein	denotes	AP-1
T17109	3883-3886	Protein	denotes	JNK
T17110	3887-3902	Protein	denotes	I or10 nM PKC-I
R4755	T5875	T5877	themeOf	NF-κB,activation
R4756	T5876	T5878	themeOf	AP-1,alter
R4757	T5877	T5879	themeOf	activation,down-regulated
R4758	T5880	T5883	themeOf	CXCL8,reduction
R4759	T5881	T5884	themeOf	CXCL8 release,alter
R4760	T5885	T5889	themeOf	TNF,expression
R4761	T5886	T5890	themeOf	NF-κB,regulator
R4762	T5889	T5891	themeOf	expression,affect
R4763	T5892	T5895	themeOf	IL-6,inhibition
R4764	T5893	T5897	causeOf	NF-κB,involvement
R4765	T5894	T5896	themeOf	IL-6,regulation
R4766	T5896	T5897	themeOf	regulation,involvement
R4767	T5898	T5901	themeOf	AP-1,increase
R4768	T5899	T5902	themeOf	NF-κB,reduce
R4769	T5900	T5903	themeOf	PKC,inhibitor
R4770	T5904	T5908	themeOf	PKC,Inhibition
R4771	T5905	T5909	themeOf	CXCL8,release
R4772	T5906	T5910	themeOf	IL-6,effect
R4773	T5907	T5911	themeOf	TNF,effect
R4774	T5908	T5912	causeOf	Inhibition,reduced
R4775	T5909	T5912	themeOf	release,reduced
R4776	T5913	T5914	themeOf	JNK,inhibition
R4777	T5914	T5915	themeOf	inhibition,effect
R4778	T5917	T5920	themeOf	c-Jun,phosphorylation
R4779	T5918	T5921	themeOf	c-Fos,phosphorylation
R4780	T5919	T5922	themeOf	p53,phosphorylation
R4781	T5920	T5923	themeOf	phosphorylation,activation
R4782	T5920	T5926	themeOf	phosphorylation,regulation
R4783	T5921	T5924	themeOf	phosphorylation,activation
R4784	T5921	T5927	themeOf	phosphorylation,regulation
R4785	T5922	T5925	themeOf	phosphorylation,activation
R4786	T5922	T5928	themeOf	phosphorylation,regulation
R4787	T5923	T5929	themeOf	activation,regulation
R4788	T5924	T5930	themeOf	activation,regulation
R4789	T5925	T5931	themeOf	activation,regulation
R4790	T5932	T5936	themeOf	JNK,Inhibition
R4791	T5933	T5937	themeOf	CXCL8,down-regulation
R4792	T5934	T5938	themeOf	IL-6,down-regulation
R4793	T5935	T5939	themeOf	TNF,expression
R4794	T5936	T5940	causeOf	Inhibition,resulted
R4795	T5936	T5941	causeOf	Inhibition,resulted
R4796	T5937	T5940	themeOf	down-regulation,resulted
R4797	T5938	T5941	themeOf	down-regulation,resulted
R4798	T5939	T5942	themeOf	expression,effect
R4799	T5943	T5944	themeOf	cxcl8 mRNA,induced
R4800	T5946	T5947	themeOf	JNK,inhibitor
R13114	T16118	T16119	themeOf	NF-κB,Inhibition
R13115	T16124	T16125	themeOf	NF-κB,inhibited
R13341	T16396	T16397	themeOf	NF-κB,regulation
R13342	T16398	T16401	themeOf	CXCL8,expression
R13343	T16401	T16402	themeOf	expression,inhibited
R13344	T16403	T16404	themeOf	TNF,expression
R13345	T16404	T16405	themeOf	expression,affected
R13346	T16407	T16409	themeOf	IL-6,expression
R13347	T16409	T16410	themeOf	expression,increased
R13348	T16410	T16411	themeOf	increased,regulation
R13589	T16696	T16698	themeOf	PKC,inhibitors
R13590	T16697	T16699	themeOf	JNK,inhibitors
R13591	T16700	T16701	themeOf	CXCL8,expression
R13592	T16701	T16702	themeOf	expression,inhibited
R13593	T16704	T16706	themeOf	IL-6,expression
R13594	T16707	T16708	themeOf	TNF,expression
R13595	T16708	T16709	themeOf	expression,affected

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T4708	596-605	Regulation	denotes	regulator	true
T4709	609-614	Protein	denotes	CXCL8
T4710	622-631	Positive_regulation	denotes	following
T4711	725-735	Negative_regulation	denotes	inhibition
T4712	739-743	Protein	denotes	IL-6
T4713	744-753	Positive_regulation	denotes	following
T4714	777-787	Negative_regulation	denotes	inhibition
T4715	788-797	Positive_regulation	denotes	following
T4716	845-856	Regulation	denotes	involvement		true
T4717	869-873	Protein	denotes	IL-6
T4718	874-884	Regulation	denotes	regulation
T4719	2411-2418	Negative_regulation	denotes	reduced
T4720	2419-2424	Protein	denotes	CXCL8
T4721	2425-2432	Localization	denotes	release
T4722	2479-2485	Regulation	denotes	effect
T4723	2489-2493	Protein	denotes	IL-6
T4724	2706-2721	Phosphorylation	denotes	phosphorylation
T4725	2706-2721	Phosphorylation	denotes	phosphorylation
T4726	2706-2721	Phosphorylation	denotes	phosphorylation
T4727	2726-2736	Positive_regulation	denotes	activation
T4728	2726-2736	Positive_regulation	denotes	activation
T4729	2726-2736	Positive_regulation	denotes	activation
T4730	2740-2745	Protein	denotes	c-Jun
T4731	2747-2752	Protein	denotes	c-Fos
T4732	2757-2760	Protein	denotes	p53
T4733	2829-2837	Positive_regulation	denotes	resulted
T4734	2829-2837	Positive_regulation	denotes	resulted
T4735	2843-2858	Negative_regulation	denotes	down-regulation
T4736	2843-2858	Negative_regulation	denotes	down-regulation
T4737	2867-2872	Protein	denotes	CXCL8
T4738	2877-2881	Protein	denotes	IL-6
T4739	3015-3022	Positive_regulation	denotes	induced
T4740	3015-3022	Positive_regulation	denotes	induced
T4741	3028-3032	Protein	denotes	il-6
T4742	3037-3042	Protein	denotes	cxcl8
T4743	3043-3047	Transcription	denotes	mRNA
T4744	3043-3047	Transcription	denotes	mRNA
T4745	3146-3153	Negative_regulation	denotes	reduced
T4746	3158-3162	Protein	denotes	il-6
T4747	3163-3173	Transcription	denotes	expression
T4748	3217-3222	Protein	denotes	cxcl8
T4749	3223-3229	Transcription	denotes	levels
T4750	3235-3245	Negative_regulation	denotes	suppressed
T4751	3280-3288	Regulation	denotes	remained	true
T4752	3289-3297	Positive_regulation	denotes	elevated
T15870	970-980	Protein	denotes	luciferase
T16152	1604-1609	Protein	denotes	CXCL8
T16153	1610-1620	Gene_expression	denotes	expression
T16154	1635-1644	Negative_regulation	denotes	inhibited
T16155	1712-1719	Regulation	denotes	altered	true
T16156	1790-1799	Positive_regulation	denotes	induction
T16157	1807-1816	Regulation	denotes	regulated
T16158	1874-1878	Protein	denotes	IL-6
T16159	1879-1886	Localization	denotes	release
T16160	1902-1911	Negative_regulation	denotes	inhibited
T16161	1954-1964	Regulation	denotes	regulation
T16162	1985-1989	Protein	denotes	IL-6
T16163	1990-2000	Gene_expression	denotes	expression
T16164	2019-2028	Positive_regulation	denotes	increased
T16429	3501-3506	Protein	denotes	CXCL8
T16430	3507-3517	Gene_expression	denotes	expression
T16431	3522-3531	Negative_regulation	denotes	inhibited
T16432	3542-3551	Regulation	denotes	dependent
T16433	3609-3626	Negative_regulation	denotes	inhibitory effect
T16434	3630-3634	Protein	denotes	IL-6
T16435	3635-3645	Gene_expression	denotes	expression
T4701	385-394	Negative_regulation	denotes	reduction
T4702	398-403	Protein	denotes	CXCL8
T4703	404-413	Positive_regulation	denotes	following
T4704	445-450	Regulation	denotes	alter	true
T4705	455-460	Protein	denotes	CXCL8
T4706	461-468	Localization	denotes	release
T4707	469-478	Positive_regulation	denotes	following
R3787	T4712	T4711	themeOf	IL-6,inhibition
R3788	T4712	T4713	themeOf	IL-6,following
R3789	T4712	T4714	themeOf	IL-6,inhibition
R3790	T4712	T4715	themeOf	IL-6,following
R3791	T4717	T4718	themeOf	IL-6,regulation
R3792	T4718	T4716	themeOf	regulation,involvement
R3793	T4720	T4721	themeOf	CXCL8,release
R3794	T4721	T4719	themeOf	release,reduced
R3795	T4723	T4722	themeOf	IL-6,effect
R3796	T4730	T4726	themeOf	c-Jun,phosphorylation
R3797	T4730	T4727	themeOf	c-Jun,activation
R3798	T4731	T4724	themeOf	c-Fos,phosphorylation
R3799	T4731	T4728	themeOf	c-Fos,activation
R3800	T4732	T4725	themeOf	p53,phosphorylation
R3801	T4732	T4729	themeOf	p53,activation
R3808	T4743	T4739	themeOf	mRNA,induced
R3809	T4744	T4740	themeOf	mRNA,induced
R3810	T4746	T4747	themeOf	il-6,expression
R3811	T4747	T4745	themeOf	expression,reduced
R3812	T4748	T4749	themeOf	cxcl8,levels
R3813	T4749	T4750	themeOf	levels,suppressed
R3814	T4749	T4752	themeOf	levels,elevated
R3815	T4752	T4751	themeOf	elevated,remained
R13360	T16429	T16430	themeOf	CXCL8,expression
R13361	T16430	T16431	themeOf	expression,inhibited
R13362	T16431	T16432	themeOf	inhibited,dependent
R13363	T16434	T16435	themeOf	IL-6,expression
R13364	T16435	T16433	themeOf	expression,inhibitory effect
R3780	T4702	T4703	themeOf	CXCL8,following
R3781	T4703	T4701	themeOf	following,reduction
R3782	T4705	T4706	themeOf	CXCL8,release
R3783	T4706	T4707	themeOf	release,following
R3784	T4707	T4704	themeOf	following,alter
R3785	T4709	T4710	themeOf	CXCL8,following
R3786	T4710	T4708	themeOf	following,regulator
R3802	T4735	T4734	themeOf	down-regulation,resulted
R3803	T4736	T4733	themeOf	down-regulation,resulted
R3804	T4737	T4736	themeOf	CXCL8,down-regulation
R3805	T4738	T4735	themeOf	IL-6,down-regulation
R3806	T4741	T4744	themeOf	il-6,mRNA
R3807	T4742	T4743	themeOf	cxcl8,mRNA
R13136	T16152	T16153	themeOf	CXCL8,expression
R13137	T16153	T16154	themeOf	expression,inhibited
R13138	T16153	T16155	themeOf	expression,altered
R13139	T16153	T16156	themeOf	expression,induction
R13140	T16156	T16157	themeOf	induction,regulated
R13141	T16158	T16159	themeOf	IL-6,release
R13142	T16159	T16161	themeOf	release,regulation
R13143	T16159	T16160	themeOf	release,inhibited
R13144	T16162	T16163	themeOf	IL-6,expression
R13145	T16163	T16164	themeOf	expression,increased

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T5511	38-42	P05412	denotes	AP-1
T5512	295-299	P05412	denotes	AP-1
T5513	398-403	P10145	denotes	CXCL8
T5514	455-460	P10145	denotes	CXCL8
T5515	531-534	P01375	denotes	TNF
T5516	609-614	P10145	denotes	CXCL8
T5517	618-621	P01375	denotes	TNF
T5518	739-743	P05231	denotes	IL-6
T5519	869-873	P05231	denotes	IL-6
T5520	2213-2217	P05412	denotes	AP-1
T5521	2419-2424	P10145	denotes	CXCL8
T5522	2489-2493	P05231	denotes	IL-6
T5523	2498-2501	P01375	denotes	TNF
T5524	2740-2745	P05412	denotes	c-Jun
T5525	2742-2745	P05412	denotes	Jun
T5526	2757-2760	P04637	denotes	p53
T5527	2867-2872	P10145	denotes	CXCL8
T5528	2877-2881	P05231	denotes	IL-6
T5529	2921-2924	P01375	denotes	TNF
T5530	3028-3032	P05231	denotes	il-6
T5531	3037-3042	P10145	denotes	cxcl8
T5532	3158-3162	P05231	denotes	il-6
T5533	3217-3222	P10145	denotes	cxcl8
T16100	970-980	P08659	denotes	luciferase
T16101	1026-1030	P05412	denotes	AP-1
T16102	1253-1257	P05412	denotes	AP-1
T16311	1604-1609	P10145	denotes	CXCL8
T16312	1820-1824	P05412	denotes	AP-1
T16313	1830-1833	P01375	denotes	TNF
T16314	1874-1878	P05231	denotes	IL-6
T16315	1985-1989	P05231	denotes	IL-6
T16630	3501-3506	P10145	denotes	CXCL8
T16631	3630-3634	P05231	denotes	IL-6
T16632	3666-3669	P01375	denotes	TNF

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T4657	364-372	Positive_regulation	denotes	resulted
T4658	385-394	Negative_regulation	denotes	reduction
T4659	398-403	Protein	denotes	CXCL8	true
T4660	404-413	Positive_regulation	denotes	following
T4661	445-450	Regulation	denotes	alter
T4662	455-460	Protein	denotes	CXCL8	true
T4663	461-468	Localization	denotes	release
T4664	469-478	Positive_regulation	denotes	following
T4665	524-530	Regulation	denotes	affect
T4666	535-545	Gene_expression	denotes	expression
T4667	596-605	Regulation	denotes	regulator
T4668	609-614	Protein	denotes	CXCL8		true
T4669	622-631	Positive_regulation	denotes	following
T4670	702-710	Positive_regulation	denotes	resulted
T4671	725-735	Negative_regulation	denotes	inhibition
T4672	739-743	Protein	denotes	IL-6
T4673	744-753	Positive_regulation	denotes	following
T4674	845-856	Regulation	denotes	involvement
T4675	869-873	Protein	denotes	IL-6
T4676	874-884	Regulation	denotes	regulation
T4677	2411-2418	Negative_regulation	denotes	reduced
T4678	2419-2424	Protein	denotes	CXCL8
T4679	2425-2432	Localization	denotes	release
T4680	2479-2485	Regulation	denotes	effect
T4681	2489-2493	Protein	denotes	IL-6
T4682	2706-2721	Phosphorylation	denotes	phosphorylation
T4683	2726-2736	Positive_regulation	denotes	activation
T4684	2740-2745	Protein	denotes	c-Jun
T4685	2747-2752	Protein	denotes	c-Fos
T4686	2757-2760	Protein	denotes	p53
T4687	2829-2837	Positive_regulation	denotes	resulted
T4688	2843-2858	Negative_regulation	denotes	down-regulation
T4689	2867-2872	Protein	denotes	CXCL8
T4690	2877-2881	Protein	denotes	IL-6
T4691	2925-2935	Gene_expression	denotes	expression	true
T4692	3015-3022	Positive_regulation	denotes	induced
T4693	3028-3032	Protein	denotes	il-6
T4694	3037-3042	Protein	denotes	cxcl8
T4695	3146-3153	Negative_regulation	denotes	reduced
T4696	3158-3162	Protein	denotes	il-6
T4697	3163-3173	Gene_expression	denotes	expression
T4698	3217-3222	Protein	denotes	cxcl8
T4699	3235-3245	Negative_regulation	denotes	suppressed
T4700	3289-3297	Positive_regulation	denotes	elevated
T15869	970-980	Protein	denotes	luciferase
T16139	1604-1609	Protein	denotes	CXCL8
T16140	1610-1620	Gene_expression	denotes	expression
T16141	1635-1644	Negative_regulation	denotes	inhibited	true
T16142	1834-1844	Gene_expression	denotes	expression
T16143	1853-1861	Regulation	denotes	affected
T16144	1874-1878	Protein	denotes	IL-6
T16145	1879-1886	Localization	denotes	release
T16146	1902-1911	Negative_regulation	denotes	inhibited
T16147	1919-1928	Positive_regulation	denotes	following
T16148	1954-1964	Regulation	denotes	regulation
T16149	1985-1989	Protein	denotes	IL-6
T16150	1990-2000	Gene_expression	denotes	expression
T16151	2019-2028	Positive_regulation	denotes	increased
T16419	3501-3506	Protein	denotes	CXCL8
T16420	3507-3517	Gene_expression	denotes	expression
T16421	3522-3531	Negative_regulation	denotes	inhibited
T16422	3542-3551	Regulation	denotes	dependent
T16423	3609-3619	Negative_regulation	denotes	inhibitory
T16424	3620-3626	Regulation	denotes	effect
T16425	3630-3634	Protein	denotes	IL-6
T16426	3635-3645	Gene_expression	denotes	expression
T16427	3670-3680	Gene_expression	denotes	expression
T16428	3689-3697	Regulation	denotes	affected
R3750	T4658	T4657	themeOf	reduction,resulted
R3751	T4659	T4658	themeOf	CXCL8,reduction
R3752	T4662	T4663	themeOf	CXCL8,release
R3753	T4663	T4661	themeOf	release,alter
R3754	T4663	T4664	themeOf	release,following
R3755	T4666	T4665	themeOf	expression,affect
R3756	T4668	T4669	themeOf	CXCL8,following
R3757	T4669	T4667	themeOf	following,regulator
R3758	T4671	T4670	themeOf	inhibition,resulted
R3759	T4672	T4671	themeOf	IL-6,inhibition
R3760	T4675	T4676	themeOf	IL-6,regulation
R3761	T4676	T4674	themeOf	regulation,involvement
R3762	T4678	T4679	themeOf	CXCL8,release
R3763	T4679	T4677	themeOf	release,reduced
R3764	T4681	T4680	themeOf	IL-6,effect
R3765	T4684	T4683	themeOf	c-Jun,activation
R3766	T4684	T4682	themeOf	c-Jun,phosphorylation
R3767	T4685	T4683	themeOf	c-Fos,activation
R3768	T4685	T4682	themeOf	c-Fos,phosphorylation
R3769	T4686	T4682	themeOf	p53,phosphorylation
R3770	T4686	T4683	themeOf	p53,activation
R3771	T4688	T4687	themeOf	down-regulation,resulted
R3772	T4689	T4688	themeOf	CXCL8,down-regulation
R3773	T4690	T4688	themeOf	IL-6,down-regulation
R3774	T4693	T4692	themeOf	il-6,induced
R3775	T4694	T4692	themeOf	cxcl8,induced
R3776	T4696	T4697	themeOf	il-6,expression
R3777	T4697	T4695	themeOf	expression,reduced
R3778	T4698	T4699	themeOf	cxcl8,suppressed
R3779	T4698	T4700	themeOf	cxcl8,elevated
R13126	T16139	T16140	themeOf	CXCL8,expression
R13127	T16140	T16141	themeOf	expression,inhibited
R13128	T16142	T16143	themeOf	expression,affected
R13129	T16144	T16145	themeOf	IL-6,release
R13130	T16145	T16146	themeOf	release,inhibited
R13131	T16145	T16148	themeOf	release,regulation
R13132	T16145	T16147	themeOf	release,following
R13133	T16149	T16150	themeOf	IL-6,expression
R13134	T16150	T16151	themeOf	expression,increased
R13135	T16150	T16148	themeOf	expression,regulation
R13354	T16419	T16420	themeOf	CXCL8,expression
R13355	T16420	T16421	themeOf	expression,inhibited
R13356	T16421	T16422	themeOf	inhibited,dependent
R13357	T16425	T16426	themeOf	IL-6,expression
R13358	T16426	T16424	themeOf	expression,effect
R13359	T16427	T16428	themeOf	expression,affected

PMC:2889865 / 10742-14966 JSONTXT

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PMC:2889865 / 10742-14966 JSON TXT