PMC:2848222 / 12275-13375 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2848222","sourcedb":"PMC","sourceid":"2848222","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2848222","text":"In exon 1 and 2 of the K-ras gene, 34 mutations were found in 33 of 101 samples (32.7%); all of which were substitutions and missense mutations. Thirty of 34 mutations (88.2%) were found in codon 12. The most frequently observed mutations were heterozygous 35G\u003eA transitions (16/34 mutations) and heterozygous 34 G\u003eT transitions (6/34 mutations) in codon 12, leading to transitions of Gly12Asp and Gly12Cys, respectively. Other mutations in codon 12 included three heterozygous 34G\u003eA (Gly12Ser), one homozygous 35G\u003eA (Gly12Asp), one heterozygous 35G\u003eC (Gly12Ala), one heterozygous 35G\u003eT (Gly12Val), one homozygous 34G\u003eT (Gly12Cys), and one homozygous 34G\u003eA (Gly12Ser) transitions. One sample with heterozygous 35G\u003eA transition in codon 12 was also found with homozygous 205G\u003eA transition in codon 69, leading to a transition of Asp69Asn. The other mutations were one heterozygous 38 G\u003eA (Gly13Asp) in codon 13, one homozygous 133G\u003eA (Val45Ile) in codon 45, and one heterozygous 239G\u003eA (Cys80Tyr) in codon 80 (Table 2 and Fig 1). No samples were detected with concurrent EGFR and K-ras gene mutations.","tracks":[]}