PMC:2817507 / 1397-2136 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2817507","sourcedb":"PMC","sourceid":"2817507","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2817507","text":"Intracerebral hemorrhage (ICH) represents 10%–15% of all strokes and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke, which is associated with high mortality and severe disability in survivors [1, 2]. Local brain tissue deformation induces primary brain damage after ICH; more importantly, the excitotoxicity and inflammatory responses in the brain tissue induced by ICH result in further brain damage following ICH [3]. Both innate and adaptive immunological/inflammatory mechanisms have been clearly shown to participate in the progression of brain injury after ischemic stroke. 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