PMC:2817507 / 12025-18287 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
20150961-11898581-67933708	185-186	11898581	denotes	1
20150961-16680558-67933709	348-350	16680558	denotes	10
20150961-15861332-67933710	866-868	15861332	denotes	11
20150961-12356687-67933711	1479-1481	12356687	denotes	12
20150961-11896392-67933712	1483-1485	11896392	denotes	13
20150961-19326286-67933713	1644-1646	19326286	denotes	14
20150961-17250675-67933714	1806-1808	17250675	denotes	15
20150961-10548686-67933715	1937-1939	10548686	denotes	16
20150961-17261732-67933716	2125-2127	17261732	denotes	17
20150961-10963608-67933717	2412-2413	10963608	denotes	4
20150961-12356687-67933718	2489-2491	12356687	denotes	12
20150961-11896392-67933719	2493-2495	11896392	denotes	13
20150961-17884182-67933720	2704-2705	17884182	denotes	8
20150961-17261732-67933721	2899-2901	17261732	denotes	17
20150961-17971790-67933722	3865-3867	17971790	denotes	18
20150961-10679407-67933723	4544-4545	10679407	denotes	5
20150961-11477402-67933724	4547-4548	11477402	denotes	6
20150961-12906258-67933725	5093-5095	12906258	denotes	20
20150961-18705926-67933726	5521-5523	18705926	denotes	21

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T7536	6007-6009	IN	denotes	of
T7535	5996-6006	NN	denotes	activation
T7534	5992-5995	DT	denotes	the
T7533	5989-5991	IN	denotes	of
T7532	5981-5988	NN	denotes	profile
T7531	5972-5980	JJ	denotes	temporal
T7530	5968-5971	DT	denotes	the
T7529	5955-5967	VB	denotes	demonstrated
T7528	5949-5954	NN	denotes	study
T7527	5941-5948	JJ	denotes	present
T7526	5937-5940	DT	denotes	the
T7525	5935-5936	-COMMA-	denotes	,
T7524	5925-5935	NN	denotes	conclusion
T7523	5922-5924	IN	denotes	In
T7522	5912-5920	NN	denotes	research
T7521	5904-5911	JJ	denotes	further
T7520	5896-5903	IN	denotes	through
T7519	5885-5895	VB	denotes	identified
T7518	5882-5884	VB	denotes	be
T7517	5879-5881	TO	denotes	to
T7516	5874-5878	VB	denotes	need
T7515	5870-5873	CC	denotes	and
T7514	5859-5869	VB	denotes	determined
T7513	5854-5858	VB	denotes	been
T7512	5850-5853	RB	denotes	not
T7511	5845-5849	VB	denotes	have
T7510	5839-5844	NN	denotes	brain
T7509	5827-5838	JJ	denotes	hemorrhagic
T7508	5824-5826	IN	denotes	in
T7507	5819-5823	NN	denotes	TLR4
T7506	5815-5818	IN	denotes	for
T7505	5807-5814	NN	denotes	ligands
T7504	5796-5806	JJ	denotes	endogenous
T7503	5787-5795	JJ	denotes	specific
T7502	5783-5786	DT	denotes	the
T7501	5781-5782	-COMMA-	denotes	,
T7500	5774-5781	RB	denotes	However
T7499	5767-5772	NN	denotes	brain
T7498	5763-5766	NN	denotes	IHC
T7497	5760-5762	IN	denotes	in
T7496	5750-5759	NN	denotes	responses
T7495	5737-5749	JJ	denotes	inflammatory
T7494	5733-5736	DT	denotes	the
T7493	5724-5732	VB	denotes	initiate
T7492	5720-5723	CC	denotes	and
T7491	5718-5719	-COMMA-	denotes	,
T7490	5709-5718	NN	denotes	signaling
T7489	5704-5708	NN	denotes	NFκB
T7488	5690-5703	JJ	denotes	TLR4-mediated
T7487	5681-5689	VB	denotes	activate
T7486	5679-5680	-COMMA-	denotes	,
T7485	5672-5679	NN	denotes	ligands
T7484	5667-5671	NN	denotes	TLR4
T7483	5656-5666	JJ	denotes	endogenous
T7482	5653-5655	IN	denotes	as
T7481	5646-5652	NN	denotes	server
T7480	5639-5645	NN	denotes	plasma
T7479	5636-5638	IN	denotes	of
T7478	5623-5635	NN	denotes	constituents
T7477	5619-5622	CC	denotes	and
T7476	5613-5618	NN	denotes	cells
T7475	5607-5612	NN	denotes	blood
T7474	5602-5606	IN	denotes	from
T7473	5597-5601	VB	denotes	came
T7472	5594-5596	CC	denotes	or
T7471	5588-5593	NN	denotes	brain
T7470	5580-5587	VB	denotes	damaged
T7469	5577-5579	IN	denotes	in
T7468	5568-5576	VB	denotes	produced
T7467	5558-5567	NN	denotes	molecules
T7466	5552-5557	DT	denotes	these
T7465	5547-5551	IN	denotes	that
T7464	5536-5546	VB	denotes	speculated
T7463	5533-5535	VB	denotes	be
T7462	5529-5532	MD	denotes	may
T7461	5526-5528	PRP	denotes	It
T7460	5523-5524	-RRB-	denotes	]
T7459	5521-5523	CD	denotes	21
T7458	5520-5521	-LRB-	denotes	[
T7457	5514-5519	NN	denotes	cells
T7456	5508-5513	NN	denotes	blood
T7455	5505-5507	CC	denotes	or
T7454	5499-5504	NN	denotes	cells
T7453	5490-5498	JJ	denotes	neuronal
T7452	5482-5489	VB	denotes	injured
T7451	5479-5481	IN	denotes	by
T7450	5470-5478	VB	denotes	produced
T7449	5467-5469	VB	denotes	be
T7448	5463-5466	MD	denotes	may
T7447	5457-5462	WDT	denotes	which
T7446	5455-5456	-COMMA-	denotes	,
T7445	5452-5455	NN	denotes	ICH
T7444	5446-5451	IN	denotes	after
T7443	5440-5445	NN	denotes	brain
T7442	5436-5439	DT	denotes	the
T7441	5433-5435	IN	denotes	in
T7440	5421-5432	VB	denotes	upregulated
T7439	5418-5420	VB	denotes	be
T7438	5415-5417	TO	denotes	to
T7437	5409-5414	VB	denotes	found
T7436	5405-5408	VB	denotes	are
T7435	5398-5404	NN	denotes	stress
T7434	5388-5397	JJ	denotes	oxidative
T7433	5385-5387	IN	denotes	in
T7432	5376-5384	VB	denotes	involved
T7431	5368-5375	NN	denotes	enzymes
T7430	5364-5367	CC	denotes	and
T7429	5362-5363	-COMMA-	denotes	,
T7428	5357-5362	NN	denotes	HSP27
T7427	5355-5356	-COMMA-	denotes	,
T7426	5350-5355	NN	denotes	HSP32
T7425	5348-5349	-COMMA-	denotes	,
T7424	5343-5348	NN	denotes	HSP70
T7423	5341-5342	-COMMA-	denotes	,
T7422	5333-5341	NN	denotes	instance
T7421	5329-5332	IN	denotes	For
T7420	5315-5327	NN	denotes	inflammation
T7419	5312-5314	IN	denotes	by
T7418	5302-5311	VB	denotes	activated
T7417	5298-5301	VB	denotes	are
T7416	5293-5297	WDT	denotes	that
T7415	5287-5292	NN	denotes	genes
T7414	5284-5286	IN	denotes	of
T7413	5275-5283	NN	denotes	products
T7412	5271-5274	CC	denotes	and
T7411	5269-5270	-COMMA-	denotes	,
T7410	5264-5269	NN	denotes	cells
T7409	5255-5263	JJ	denotes	ruptured
T7408	5252-5254	IN	denotes	of
T7407	5241-5251	NN	denotes	components
T7406	5227-5240	JJ	denotes	intracellular
T7405	5225-5226	-COMMA-	denotes	,
T7404	5217-5225	NN	denotes	cascades
T7403	5205-5216	JJ	denotes	proteolytic
T7402	5202-5204	IN	denotes	of
T7401	5193-5201	NN	denotes	products
T7400	5191-5192	-COMMA-	denotes	,
T7399	5177-5191	NN	denotes	macromolecules
T7398	5174-5176	IN	denotes	of
T7397	5165-5173	NN	denotes	products
T7396	5153-5164	NN	denotes	degradation
T7395	5149-5152	DT	denotes	the
T7394	5146-5148	IN	denotes	as
T7393	5141-5145	JJ	denotes	such
T7392	5131-5140	NN	denotes	molecules
T7391	5120-5130	JJ	denotes	endogenous
T7390	5110-5119	VB	denotes	recognize
T7389	5105-5109	RB	denotes	also
T7388	5101-5104	MD	denotes	can
T7387	5097-5100	CC	denotes	and
T7386	5095-5096	-RRB-	denotes	]
T7385	5093-5095	CD	denotes	20
T7384	5091-5092	-COMMA-	denotes	,
T7383	5089-5091	CD	denotes	19
T7382	5088-5089	-LRB-	denotes	[
T7381	5077-5087	NN	denotes	components
T7380	5067-5076	JJ	denotes	microbial
T7379	5064-5066	IN	denotes	of
T7378	5052-5063	NN	denotes	recognition
T7377	5048-5051	DT	denotes	the
T7376	5045-5047	IN	denotes	in
T7375	5040-5044	NN	denotes	role
T7374	5030-5039	JJ	denotes	important
T7373	5027-5029	DT	denotes	an
T7372	5021-5026	VB	denotes	plays
T7371	5016-5020	NN	denotes	TLR4
T7370	5007-5014	NN	denotes	pathway
T7369	4997-5006	NN	denotes	signaling
T7368	4983-4996	JJ	denotes	TLR4-mediated
T7367	4979-4982	DT	denotes	the
T7366	4971-4978	IN	denotes	through
T7365	4961-4970	VB	denotes	regulated
T7364	4958-4960	VB	denotes	is
T7363	4953-4957	NN	denotes	NFκB
T7362	4950-4952	IN	denotes	of
T7361	4939-4949	NN	denotes	activation
T7360	4934-4938	IN	denotes	that
T7359	4926-4933	NN	denotes	reports
T7358	4917-4925	JJ	denotes	previous
T7357	4912-4916	IN	denotes	with
T7356	4901-4911	JJ	denotes	consistent
T7355	4898-4900	VB	denotes	is
T7354	4892-4897	WDT	denotes	which
T7353	4890-4891	-COMMA-	denotes	,
T7352	4883-4890	NN	denotes	pathway
T7351	4873-4882	NN	denotes	signaling
T7350	4863-4872	NN	denotes	TLR4/NFκB
T7349	4859-4862	DT	denotes	the
T7348	4856-4858	IN	denotes	of
T7347	4845-4855	NN	denotes	activation
T7346	4834-4844	VB	denotes	stimulates
T7345	4830-4833	NN	denotes	ICH
T7344	4825-4829	IN	denotes	that
T7343	4817-4824	VB	denotes	suggest
T7342	4812-4816	NN	denotes	data
T7341	4808-4811	PRP-DOLLAR-	denotes	Our
T7340	4802-4806	NN	denotes	TLR4
T7339	4799-4801	IN	denotes	of
T7338	4788-4798	NN	denotes	expression
T7337	4784-4787	DT	denotes	the
T7336	4781-4783	IN	denotes	of
T7335	4776-4780	DT	denotes	that
T7334	4773-4775	TO	denotes	to
T7333	4765-4772	JJ	denotes	similar
T7332	4761-4764	VB	denotes	was
T7331	4756-4760	NN	denotes	NFκB
T7330	4753-4755	IN	denotes	of
T7329	4742-4752	NN	denotes	activation
T7328	4738-4741	DT	denotes	the
T7327	4734-4737	CC	denotes	and
T7326	4728-4733	NN	denotes	p-IκB
T7325	4725-4727	IN	denotes	of
T7324	4714-4724	NN	denotes	expression
T7323	4710-4713	DT	denotes	the
T7322	4707-4709	IN	denotes	of
T7321	4699-4706	NN	denotes	profile
T7288	4509-4515	JJ	denotes	immune
T7287	4502-4508	JJ	denotes	innate
T7286	4497-4501	IN	denotes	with
T7285	4486-4496	VB	denotes	associated
T7284	4480-4485	NN	denotes	genes
T7283	4477-4479	IN	denotes	of
T7282	4463-4476	NN	denotes	transcription
T7281	4453-4462	VB	denotes	initiates
T7280	4447-4452	WDT	denotes	which
T7279	4445-4446	-COMMA-	denotes	,
T7278	4441-4445	NN	denotes	NFκB
T7277	4438-4440	IN	denotes	of
T7276	4424-4437	NN	denotes	translocation
T7275	4416-4423	JJ	denotes	nuclear
T7274	4413-4415	IN	denotes	in
T7273	4403-4412	VB	denotes	resulting
T7272	4401-4402	-COMMA-	denotes	,
T7271	4390-4401	NN	denotes	degradation
T7270	4386-4389	CC	denotes	and
T7269	4370-4385	NN	denotes	phosphorylation
T7268	4365-4369	NN	denotes	IκBα
T7267	4354-4364	VB	denotes	stimulates
T7266	4349-4353	NN	denotes	TLR4
T7265	4346-4348	IN	denotes	of
T7264	4335-4345	NN	denotes	Activation
T7263	4326-4333	NN	denotes	pathway
T7262	4316-4325	NN	denotes	signaling
T7261	4302-4315	JJ	denotes	TLR4-mediated
T7260	4298-4301	DT	denotes	the
T7259	4295-4297	IN	denotes	in
T7258	4284-4294	RB	denotes	downstream
T7257	4277-4283	NN	denotes	factor
T7256	4263-4276	NN	denotes	transcription
T7255	4253-4262	JJ	denotes	important
T7254	4250-4252	DT	denotes	an
T7253	4247-4249	VB	denotes	is
T7252	4242-4246	NN	denotes	NFκB
T7251	4234-4240	NN	denotes	brains
T7250	4222-4233	JJ	denotes	hemorrhagic
T7249	4219-4221	IN	denotes	in
T7248	4214-4218	NN	denotes	NFκB
T7247	4211-4213	IN	denotes	of
T7246	4202-4210	NN	denotes	activity
T7245	4198-4201	DT	denotes	the
T7244	4194-4197	CC	denotes	and
T7243	4188-4193	NN	denotes	p-IκB
T7242	4184-4187	DT	denotes	the
T7241	4174-4183	VB	denotes	detecting
T7240	4171-4173	IN	denotes	by
T7239	4161-4170	NN	denotes	signaling
T7238	4156-4160	NN	denotes	NFκB
T7237	4142-4155	JJ	denotes	TLR4-mediated
T7236	4139-4141	IN	denotes	of
T7235	4128-4138	NN	denotes	activation
T7234	4124-4127	DT	denotes	the
T7233	4114-4123	VB	denotes	evaluated
T7232	4111-4113	PRP	denotes	we
T7231	4109-4110	-COMMA-	denotes	,
T7230	4104-4109	NN	denotes	study
T7229	4096-4103	JJ	denotes	present
T7228	4092-4095	DT	denotes	the
T7227	4089-4091	IN	denotes	in
T7226	4087-4088	-COMMA-	denotes	,
T7225	4084-4087	NN	denotes	ICH
T7224	4078-4083	IN	denotes	after
T7223	4072-4077	NN	denotes	brain
T7222	4068-4071	DT	denotes	the
T7221	4065-4067	IN	denotes	in
T7220	4055-4064	NN	denotes	responses
T7219	4042-4054	JJ	denotes	inflammatory
T7218	4032-4041	VB	denotes	increased
T7217	4028-4031	DT	denotes	the
T7216	4017-4027	VB	denotes	underlying
T7215	4006-4016	NN	denotes	mechanisms
T7214	4002-4005	DT	denotes	the
T7213	3990-4001	VB	denotes	investigate
T7212	3987-3989	TO	denotes	To
T7211	3976-3985	NN	denotes	responses
T7210	3963-3975	JJ	denotes	inflammatory
T7209	3959-3962	CC	denotes	and
T7208	3945-3958	JJ	denotes	immunological
T7207	3935-3944	VB	denotes	regulates
T7206	3931-3934	CC	denotes	and
T7205	3921-3930	VB	denotes	activates
T7204	3913-3920	NN	denotes	pathway
T7203	3894-3912	NN	denotes	TLR4-mediated-NFκB
T7202	3889-3893	IN	denotes	that
T7201	3880-3888	VB	denotes	believed
T7200	3876-3879	RB	denotes	now
T7199	3873-3875	VB	denotes	is
T7198	3870-3872	PRP	denotes	It
T7197	3867-3868	-RRB-	denotes	]
T7196	3865-3867	CD	denotes	18
T7195	3864-3865	-LRB-	denotes	[
T7194	3858-3863	NN	denotes	death
T7193	3853-3857	NN	denotes	cell
T7192	3849-3852	CC	denotes	and
T7191	3838-3848	NN	denotes	hemorrhage
T7190	3835-3837	IN	denotes	of
T7189	3828-3834	NN	denotes	growth
T7188	3818-3827	JJ	denotes	secondary
T7187	3813-3817	IN	denotes	with
T7186	3802-3812	VB	denotes	associated
T7185	3798-3801	VB	denotes	are
T7184	3792-3797	WDT	denotes	which
T7183	3790-3791	-COMMA-	denotes	,
T7182	3781-3790	NN	denotes	responses
T7181	3768-3780	JJ	denotes	inflammatory
T7180	3758-3767	VB	denotes	initiates
T7179	3754-3757	NN	denotes	ICH
T7178	3749-3753	IN	denotes	that
T7177	3736-3748	VB	denotes	demonstrated
T7176	3728-3735	NN	denotes	studies
T7175	3721-3727	JJ	denotes	Recent
T7174	3716-3719	NN	denotes	ICH
T7173	3710-3715	IN	denotes	after
T7172	3703-3709	NN	denotes	tissue
T7171	3697-3702	NN	denotes	brain
T7170	3693-3696	DT	denotes	the
T7169	3690-3692	IN	denotes	in
T7168	3680-3689	NN	denotes	responses
T7167	3667-3679	JJ	denotes	inflammatory
T7166	3663-3666	DT	denotes	the
T7165	3660-3662	IN	denotes	of
T7164	3649-3659	NN	denotes	triggering
T7163	3645-3648	DT	denotes	the
T7162	3642-3644	TO	denotes	to
T7161	3634-3641	JJ	denotes	related
T7160	3631-3633	VB	denotes	be
T7159	3627-3630	MD	denotes	may
T7158	3622-3626	NN	denotes	TLR4
T7157	3619-3621	IN	denotes	of
T7156	3608-3618	NN	denotes	expression
T7155	3598-3607	VB	denotes	increased
T7154	3593-3597	IN	denotes	that
T7153	3583-3592	VB	denotes	indicated
T7152	3578-3582	NN	denotes	data
T7151	3572-3577	DT	denotes	These
T7150	3564-3570	NN	denotes	tracts
T7149	3557-3563	NN	denotes	matter
T7148	3551-3556	JJ	denotes	white
T7147	3546-3550	DT	denotes	some
T7146	3542-3545	CC	denotes	and
T7145	3540-3541	-COMMA-	denotes	,
T7144	3534-3540	NN	denotes	nuclei
T7143	3525-3533	JJ	denotes	thalamic
T7142	3523-3524	-COMMA-	denotes	,
T7141	3517-3523	NN	denotes	cortex
T7140	3515-3516	-COMMA-	denotes	,
T7139	3504-3515	NN	denotes	hippocampus
T7138	3500-3503	DT	denotes	the
T7137	3498-3499	-COMMA-	denotes	,
T7136	3493-3498	NN	denotes	areas
T7135	3477-3492	JJ	denotes	peri-hemorrhage
T7134	3474-3476	IN	denotes	in
T7133	3462-3473	VB	denotes	distributed
T7132	3449-3461	RB	denotes	consistently
T7131	3445-3448	VB	denotes	was
T7130	3443-3444	-COMMA-	denotes	,
T7129	3423-3443	NN	denotes	immunohistochemistry
T7128	3420-3422	IN	denotes	by
T7127	3411-3419	VB	denotes	detected
T7126	3409-3410	-COMMA-	denotes	,
T7125	3402-3409	NN	denotes	protein
T7576	6255-6261	NN	denotes	damage
T7575	6249-6254	NN	denotes	brain
T7574	6237-6248	JJ	denotes	ICH-induced
T7573	6234-6236	IN	denotes	of
T7572	6223-6233	NN	denotes	prevention
T7571	6219-6222	DT	denotes	the
T7570	6215-6218	IN	denotes	for
T7569	6208-6214	NN	denotes	target
T7568	6196-6207	JJ	denotes	therapeutic
T7567	6194-6195	DT	denotes	a
T7566	6191-6193	VB	denotes	be
T7565	6187-6190	MD	denotes	may
T7564	6181-6186	WDT	denotes	which
T7563	6179-6180	-COMMA-	denotes	,
T7562	6176-6179	NN	denotes	ICH
T7561	6173-6175	IN	denotes	of
T7560	6160-6172	NN	denotes	pathogenesis
T7559	6156-6159	DT	denotes	the
T7558	6153-6155	IN	denotes	in
T7557	6140-6152	VB	denotes	participates
T7556	6130-6139	NN	denotes	signaling
T7555	6125-6129	NN	denotes	NFκB
T7554	6111-6124	JJ	denotes	TLR4-mediated
T7553	6106-6110	IN	denotes	that
T7552	6097-6105	VB	denotes	suggests
T7551	6091-6096	WDT	denotes	which
T7550	6089-6090	-COMMA-	denotes	,
T7549	6086-6089	NN	denotes	ICH
T7548	6073-6085	JJ	denotes	experimental
T7547	6070-6072	IN	denotes	of
T7546	6064-6069	NN	denotes	model
T7545	6060-6063	NN	denotes	rat
T7544	6058-6059	DT	denotes	a
T7543	6055-6057	IN	denotes	in
T7542	6048-6054	NN	denotes	tissue
T7541	6042-6047	NN	denotes	brain
T7540	6039-6041	IN	denotes	in
T7539	6029-6038	NN	denotes	signaling
T7538	6024-6028	NN	denotes	NFκB
T7537	6010-6023	JJ	denotes	TLR4-mediated
T7124	3397-3401	NN	denotes	TLR4
T7123	3393-3396	DT	denotes	The
T7122	3382-3391	RB	denotes	afterward
T7121	3377-3381	NN	denotes	days
T7120	3375-3376	CD	denotes	7
T7119	3371-3374	IN	denotes	for
T7118	3365-3370	NN	denotes	level
T7117	3360-3364	JJ	denotes	high
T7116	3358-3359	DT	denotes	a
T7115	3355-3357	IN	denotes	at
T7114	3344-3354	VB	denotes	maintained
T7113	3340-3343	CC	denotes	and
T7112	3333-3339	NN	denotes	insult
T7111	3329-3332	NN	denotes	ICH
T7110	3325-3328	DT	denotes	the
T7109	3319-3324	IN	denotes	after
T7108	3313-3318	NN	denotes	hours
T7107	3311-3312	CD	denotes	6
T7106	3308-3310	IN	denotes	as
T7105	3302-3307	RB	denotes	early
T7104	3299-3301	RB	denotes	as
T7103	3291-3298	VB	denotes	started
T7102	3283-3290	NN	denotes	changes
T7101	3277-3282	DT	denotes	These
T7100	3269-3275	NN	denotes	tissue
T7099	3263-3268	NN	denotes	brain
T7098	3260-3262	IN	denotes	in
T7097	3251-3259	JJ	denotes	elevated
T7096	3237-3250	RB	denotes	significantly
T7095	3233-3236	NN	denotes	ICH
T7094	3227-3232	IN	denotes	after
T7093	3219-3226	NN	denotes	protein
T7092	3214-3218	NN	denotes	TLR4
T7091	3211-3213	IN	denotes	of
T7090	3200-3210	NN	denotes	expression
T7089	3196-3199	DT	denotes	the
T7088	3193-3195	IN	denotes	as
T7087	3188-3192	RB	denotes	well
T7086	3185-3187	RB	denotes	as
T7085	3180-3184	NN	denotes	TLR4
T7084	3177-3179	IN	denotes	of
T7083	3163-3176	NN	denotes	transcription
T7082	3158-3162	IN	denotes	that
T7081	3151-3157	VB	denotes	showed
T7080	3146-3150	NN	denotes	data
T7079	3142-3145	PRP-DOLLAR-	denotes	Our
T7078	3133-3140	NN	denotes	protein
T7077	3129-3132	CC	denotes	and
T7076	3124-3128	NN	denotes	mRNA
T7075	3119-3123	NN	denotes	TLR4
T7074	3115-3118	DT	denotes	the
T7073	3106-3114	VB	denotes	detected
T6902	2125-2127	CD	denotes	17
T6901	2124-2125	-LRB-	denotes	[
T6900	2120-2123	NN	denotes	ICH
T6899	2117-2119	IN	denotes	by
T6898	2108-2116	VB	denotes	produced
T6897	2101-2107	NN	denotes	damage
T6896	2092-2100	JJ	denotes	neuronal
T6895	2088-2091	CC	denotes	and
T6894	2086-2087	-COMMA-	denotes	,
T6893	2075-2086	NN	denotes	dysfunction
T6892	2064-2074	JJ	denotes	behavioral
T6891	2062-2063	-COMMA-	denotes	,
T6890	2050-2062	NN	denotes	inflammation
T6889	2043-2049	NN	denotes	reduce
T6888	2040-2042	IN	denotes	as
T6887	2035-2039	JJ	denotes	such
T6886	2033-2034	-COMMA-	denotes	,
T6885	2030-2033	NN	denotes	ICH
T6884	2017-2029	JJ	denotes	experimental
T6883	2014-2016	IN	denotes	on
T6882	2007-2013	NN	denotes	effect
T6881	1995-2006	JJ	denotes	therapeutic
T6880	1993-1994	DT	denotes	a
T6879	1988-1992	VB	denotes	have
T6878	1985-1987	TO	denotes	to
T6877	1979-1984	VB	denotes	shown
T6876	1974-1978	VB	denotes	been
T6875	1970-1973	VB	denotes	has
T6874	1961-1969	NN	denotes	activity
T6873	1956-1960	NN	denotes	NFκB
T6872	1953-1955	IN	denotes	of
T6871	1942-1952	NN	denotes	Inhibition
T6870	1939-1940	-RRB-	denotes	]
T6869	1937-1939	CD	denotes	16
T6868	1936-1937	-LRB-	denotes	[
T6867	1932-1935	NN	denotes	ICH
T6866	1926-1931	IN	denotes	after
T6865	1920-1925	NN	denotes	death
T6864	1915-1919	NN	denotes	cell
T6863	1902-1914	JJ	denotes	perilesional
T6862	1899-1901	IN	denotes	of
T6861	1886-1898	NN	denotes	pathobiology
T6860	1882-1885	DT	denotes	the
T6859	1879-1881	TO	denotes	to
T6858	1867-1878	VB	denotes	contributes
T6857	1863-1866	CC	denotes	and
T6856	1853-1862	NN	denotes	responses
T6855	1840-1852	JJ	denotes	inflammatory
T6854	1830-1839	VB	denotes	initiates
T6853	1825-1829	NN	denotes	NFκB
T6852	1822-1824	IN	denotes	of
T6851	1811-1821	NN	denotes	Activation
T6850	1808-1809	-RRB-	denotes	]
T6849	1806-1808	CD	denotes	15
T6848	1805-1806	-LRB-	denotes	[
T6847	1799-1804	NN	denotes	genes
T6846	1792-1798	NN	denotes	target
T6845	1783-1791	VB	denotes	selected
T6844	1780-1782	IN	denotes	of
T6843	1769-1779	NN	denotes	expression
T6842	1765-1768	DT	denotes	the
T6841	1760-1764	IN	denotes	with
T6840	1749-1759	VB	denotes	associated
T6839	1746-1748	VB	denotes	is
T6838	1740-1745	WDT	denotes	which
T6837	1738-1739	-COMMA-	denotes	,
T6836	1735-1738	NN	denotes	ICH
T6835	1732-1734	TO	denotes	to
T6834	1723-1731	NN	denotes	response
T6833	1720-1722	IN	denotes	in
T6832	1715-1719	NN	denotes	week
T6831	1713-1714	DT	denotes	a
T6830	1707-1712	JJ	denotes	least
T6829	1704-1706	IN	denotes	at
T6828	1700-1703	IN	denotes	for
T6827	1691-1699	VB	denotes	persists
T6826	1687-1690	CC	denotes	and
T6825	1679-1686	NN	denotes	minutes
T6824	1672-1678	IN	denotes	within
T6823	1665-1671	VB	denotes	occurs
T6822	1654-1664	NN	denotes	activation
T6821	1649-1653	NN	denotes	NFκB
T6820	1646-1647	-RRB-	denotes	]
T6819	1644-1646	CD	denotes	14
T6818	1643-1644	-LRB-	denotes	[
T6817	1639-1642	NN	denotes	ICH
T6816	1633-1638	IN	denotes	after
T6815	1620-1632	NN	denotes	perihematoma
T6814	1617-1619	IN	denotes	of
T6813	1610-1616	NN	denotes	region
T6812	1606-1609	DT	denotes	the
T6811	1603-1605	IN	denotes	in
T6810	1593-1602	VB	denotes	increased
T6809	1588-1592	NN	denotes	NFκB
T6808	1583-1587	IN	denotes	that
T6807	1574-1582	VB	denotes	reported
T6806	1569-1573	VB	denotes	been
T6805	1565-1568	VB	denotes	has
T6804	1562-1564	PRP	denotes	It
T6803	1549-1560	NN	denotes	pathologies
T6802	1543-1548	NN	denotes	brain
T6801	1540-1542	IN	denotes	in
T6800	1527-1539	NN	denotes	inflammation
T6799	1516-1526	VB	denotes	regulating
T6798	1513-1515	IN	denotes	in
T6797	1508-1512	NN	denotes	role
T6796	1504-1507	JJ	denotes	key
T6795	1502-1503	DT	denotes	a
T6794	1496-1501	VB	denotes	plays
T6793	1491-1495	RB	denotes	also
T6792	1487-1490	CC	denotes	and
T6791	1485-1486	-RRB-	denotes	]
T6790	1483-1485	CD	denotes	13
T6789	1481-1482	-COMMA-	denotes	,
T6788	1479-1481	CD	denotes	12
T6787	1478-1479	-LRB-	denotes	[
T6786	1465-1477	NN	denotes	inflammation
T6785	1461-1464	CC	denotes	and
T6784	1451-1460	NN	denotes	responses
T6783	1444-1450	JJ	denotes	immune
T6782	1439-1443	IN	denotes	with
T6781	1428-1438	VB	denotes	associated
T6780	1422-1427	NN	denotes	genes
T6779	1419-1421	IN	denotes	of
T6778	1405-1418	NN	denotes	transcription
T6777	1395-1404	VB	denotes	initiates
T6776	1389-1394	WDT	denotes	which
T6775	1387-1388	-COMMA-	denotes	,
T6774	1381-1387	NN	denotes	factor
T6773	1367-1380	NN	denotes	transcription
T6772	1359-1366	JJ	denotes	nuclear
T6771	1349-1358	JJ	denotes	important
T6770	1346-1348	DT	denotes	an
T6769	1343-1345	VB	denotes	is
T6768	1341-1342	-RRB-	denotes	)
T6767	1337-1341	NN	denotes	NFκB
T6766	1336-1337	-LRB-	denotes	(
T6765	1321-1335	NN	denotes	factor-kappa-B
T6764	1313-1320	JJ	denotes	nuclear
T6763	1306-1312	NN	denotes	factor
T6762	1292-1305	NN	denotes	Transcription
T6761	1283-1290	JJ	denotes	unclear
T6760	1280-1282	VB	denotes	is
T6759	1276-1279	NN	denotes	ICH
T6758	1270-1275	IN	denotes	after
T6757	1263-1269	NN	denotes	tissue
T6756	1257-1262	NN	denotes	brain
T6755	1253-1256	DT	denotes	the
T6754	1250-1252	IN	denotes	in
T6753	1240-1249	VB	denotes	regulated
T6752	1236-1239	CC	denotes	and
T6751	1226-1235	VB	denotes	activated
T6750	1223-1225	VB	denotes	is
T6749	1213-1222	NN	denotes	responses
T6748	1200-1212	JJ	denotes	inflammatory
T6747	1196-1199	DT	denotes	the
T6746	1192-1195	WRB	denotes	how
T6745	1190-1191	-COMMA-	denotes	,
T6744	1183-1190	RB	denotes	However
T6743	1178-1181	NN	denotes	ICH
T6742	1175-1177	IN	denotes	of
T6741	1162-1174	NN	denotes	pathogenesis
T6740	1158-1161	DT	denotes	the
T6739	1155-1157	IN	denotes	in
T7320	4690-4698	JJ	denotes	temporal
T7319	4686-4689	DT	denotes	The
T7318	4681-4684	NN	denotes	ICH
T7317	4675-4680	IN	denotes	after
T7316	4668-4674	NN	denotes	tissue
T7315	4662-4667	NN	denotes	brain
T7314	4659-4661	IN	denotes	in
T7313	4649-4658	VB	denotes	increased
T7312	4635-4648	RB	denotes	significantly
T7311	4630-4634	VB	denotes	were
T7310	4625-4629	NN	denotes	NFκB
T7309	4622-4624	IN	denotes	of
T7308	4613-4621	NN	denotes	activity
T7307	4609-4612	DT	denotes	the
T7306	4605-4608	CC	denotes	and
T7305	4601-4604	NN	denotes	IκB
T7304	4598-4600	IN	denotes	of
T7303	4582-4597	NN	denotes	phosphorylation
T7302	4579-4581	IN	denotes	of
T7301	4572-4578	NN	denotes	levels
T7300	4568-4571	DT	denotes	the
T7299	4563-4567	IN	denotes	that
T7298	4554-4562	VB	denotes	observed
T7297	4551-4553	PRP	denotes	We
T7296	4548-4549	-RRB-	denotes	]
T7295	4547-4548	CD	denotes	6
T7294	4545-4546	-COMMA-	denotes	,
T7293	4544-4545	CD	denotes	5
T7292	4543-4544	-LRB-	denotes	[
T7291	4530-4542	NN	denotes	inflammation
T7290	4526-4529	CC	denotes	and
T7289	4516-4525	NN	denotes	responses
T6738	1145-1154	JJ	denotes	important
T6737	1142-1144	VB	denotes	be
T6736	1138-1141	MD	denotes	may
T6735	1136-1137	-COMMA-	denotes	,
T6734	1126-1136	NN	denotes	complement
T6733	1122-1125	CC	denotes	and
T6732	1120-1121	-COMMA-	denotes	,
T6731	1105-1120	NN	denotes	immunoglobulins
T6730	1103-1104	-COMMA-	denotes	,
T6729	1093-1103	NN	denotes	leukocytes
T6728	1091-1092	-COMMA-	denotes	,
T6727	1082-1091	NN	denotes	cytokines
T6726	1080-1081	-COMMA-	denotes	,
T6725	1071-1080	NN	denotes	molecules
T6724	1062-1070	NN	denotes	adhesion
T6723	1052-1061	VB	denotes	including
T6722	1050-1051	-COMMA-	denotes	,
T6721	1042-1050	NN	denotes	response
T6720	1029-1041	JJ	denotes	inflammatory
T6719	1025-1028	DT	denotes	the
T6718	1022-1024	IN	denotes	of
T6717	1009-1021	NN	denotes	constituents
T6716	1001-1008	JJ	denotes	Various
T6715	996-999	NN	denotes	ICH
T6714	992-995	IN	denotes	for
T6713	984-991	NN	denotes	targets
T6712	972-983	JJ	denotes	therapeutic
T6711	968-971	JJ	denotes	new
T6710	960-967	VB	denotes	provide
T6709	954-959	MD	denotes	could
T6708	948-953	WDT	denotes	which
T6707	946-947	-COMMA-	denotes	,
T6706	940-946	NN	denotes	injury
T6705	934-939	NN	denotes	brain
T6704	926-933	VB	denotes	induced
T6703	922-925	NN	denotes	ICH
T6702	918-921	DT	denotes	the
T6701	914-917	IN	denotes	for
T6700	902-913	JJ	denotes	responsible
T6699	898-901	VB	denotes	are
T6698	888-897	NN	denotes	responses
T6697	875-887	JJ	denotes	inflammatory
T6696	871-874	DT	denotes	The
T6695	868-869	-RRB-	denotes	]
T6694	866-868	CD	denotes	11
T6693	865-866	-LRB-	denotes	[
T6692	858-864	NN	denotes	agents
T6691	852-857	DT	denotes	these
T6690	849-851	IN	denotes	of
T6689	844-848	JJ	denotes	many
T6688	834-843	VB	denotes	producing
T6687	831-833	IN	denotes	of
T6586	233-241	JJ	denotes	ischemic
T6585	230-232	IN	denotes	of
T6584	225-229	DT	denotes	that
T6583	220-224	IN	denotes	than
T6582	213-219	JJ	denotes	higher
T6581	210-212	VB	denotes	is
T6580	206-209	NN	denotes	ICH
T6579	203-205	IN	denotes	of
T6578	193-202	NN	denotes	mortality
T6577	189-192	DT	denotes	The
T6576	186-187	-RRB-	denotes	]
T6575	185-186	CD	denotes	1
T6574	184-185	-LRB-	denotes	[
T6573	177-183	NN	denotes	stroke
T6572	168-176	JJ	denotes	ischemic
T6571	165-167	IN	denotes	of
T6570	155-164	NN	denotes	treatment
T6569	142-154	JJ	denotes	thrombolytic
T6568	138-141	DT	denotes	the
T6567	135-137	IN	denotes	of
T6566	122-134	NN	denotes	complication
T6565	120-121	DT	denotes	a
T6564	117-119	IN	denotes	as
T6563	107-116	NN	denotes	frequency
T6562	96-106	VB	denotes	increasing
T6561	91-95	IN	denotes	with
T6560	84-90	VB	denotes	occurs
T6559	80-83	CC	denotes	and
T6558	78-79	-COMMA-	denotes	,
T6557	71-78	NN	denotes	strokes
T6556	67-70	DT	denotes	all
T6555	64-66	IN	denotes	of
T6554	62-63	NN	denotes	%
T6553	57-62	CD	denotes	10–15
T6552	46-56	VB	denotes	represents
T6551	44-45	-RRB-	denotes	)
T6550	41-44	NN	denotes	ICH
T6549	40-41	-LRB-	denotes	(
T6548	29-39	NN	denotes	hemorrhage
T6547	14-28	JJ	denotes	Intra-cerebral
T7072	3102-3105	CC	denotes	and
T7071	3098-3101	NN	denotes	ICH
T7070	3085-3097	JJ	denotes	experimental
T7069	3082-3084	IN	denotes	of
T7068	3076-3081	NN	denotes	model
T7067	3072-3075	NN	denotes	rat
T7066	3068-3071	DT	denotes	the
T7065	3056-3067	VB	denotes	established
T7064	3053-3055	PRP	denotes	we
T7063	3051-3052	-COMMA-	denotes	,
T7062	3046-3051	NN	denotes	study
T7061	3038-3045	JJ	denotes	present
T7060	3034-3037	DT	denotes	the
T7059	3031-3033	IN	denotes	In
T7058	3026-3029	NN	denotes	ICH
T7057	3022-3025	CC	denotes	and
T7056	3012-3021	NN	denotes	signaling
T7055	3007-3011	NN	denotes	NFκB
T7054	2993-3006	JJ	denotes	TLR4-mediated
T7053	2985-2992	IN	denotes	between
T7052	2972-2984	NN	denotes	relationship
T7051	2968-2971	DT	denotes	the
T7050	2964-2967	CC	denotes	and
T7049	2959-2963	NN	denotes	role
T7048	2955-2958	DT	denotes	the
T7047	2943-2954	VB	denotes	investigate
T7046	2940-2942	TO	denotes	to
T7045	2931-2939	VB	denotes	directed
T7044	2926-2930	VB	denotes	been
T7043	2921-2925	VB	denotes	have
T7042	2913-2920	NN	denotes	studies
T7041	2909-2912	JJ	denotes	few
T7040	2904-2908	RB	denotes	very
T7039	2902-2903	-COMMA-	denotes	,
T7038	2901-2902	-RRB-	denotes	]
T7037	2899-2901	CD	denotes	17
T7036	2898-2899	-LRB-	denotes	[
T7035	2885-2897	NN	denotes	constituents
T7034	2878-2884	NN	denotes	plasma
T7033	2871-2877	CC	denotes	and/or
T7032	2865-2870	NN	denotes	cells
T7031	2859-2864	NN	denotes	blood
T7030	2855-2858	JJ	denotes	red
T7029	2852-2854	IN	denotes	by
T7028	2844-2851	VB	denotes	induced
T7027	2833-2843	NN	denotes	activation
T7026	2824-2832	NN	denotes	receptor
T7025	2814-2823	NN	denotes	glutamate
T7024	2811-2813	CC	denotes	or
T7023	2804-2810	NN	denotes	stress
T7022	2794-2803	JJ	denotes	oxidative
T7021	2790-2793	DT	denotes	the
T7020	2787-2789	TO	denotes	to
T7019	2776-2786	VB	denotes	attributed
T7018	2772-2775	VB	denotes	was
T7017	2767-2771	NN	denotes	NFκB
T7016	2764-2766	IN	denotes	of
T7015	2753-2763	NN	denotes	activation
T7014	2749-2752	DT	denotes	the
T7013	2744-2748	IN	denotes	that
T7012	2734-2743	VB	denotes	indicated
T7011	2726-2733	NN	denotes	reports
T7010	2717-2725	JJ	denotes	previous
T7009	2708-2716	IN	denotes	Although
T7008	2705-2706	-RRB-	denotes	]
T7007	2704-2705	CD	denotes	8
T7006	2702-2703	-COMMA-	denotes	,
T7005	2701-2702	CD	denotes	7
T7004	2700-2701	-LRB-	denotes	[
T7003	2693-2699	NN	denotes	injury
T7002	2684-2692	JJ	denotes	ischemic
T7001	2675-2683	JJ	denotes	cerebral
T7000	2671-2674	CC	denotes	and
T6999	2662-2670	NN	denotes	diseases
T6998	2658-2661	NN	denotes	CNS
T6997	2647-2657	JJ	denotes	autoimmune
T6996	2644-2646	CC	denotes	or
T6995	2631-2643	JJ	denotes	inflammatory
T6994	2628-2630	IN	denotes	as
T6993	2623-2627	JJ	denotes	such
T6992	2621-2622	-COMMA-	denotes	,
T6991	2613-2621	NN	denotes	diseases
T6990	2606-2612	NN	denotes	system
T6989	2604-2605	-RRB-	denotes	)
T6988	2601-2604	NN	denotes	CNS
T6987	2600-2601	-LRB-	denotes	(
T6986	2592-2599	JJ	denotes	nervous
T6985	2584-2591	JJ	denotes	central
T6984	2576-2583	JJ	denotes	several
T6983	2573-2575	IN	denotes	in
T6982	2564-2572	VB	denotes	involved
T6981	2561-2563	VB	denotes	be
T6980	2558-2560	TO	denotes	to
T6979	2549-2557	VB	denotes	reported
T6978	2544-2548	VB	denotes	been
T6977	2540-2543	VB	denotes	has
T6976	2538-2539	-COMMA-	denotes	,
T6975	2528-2538	VB	denotes	recognized
T6974	2524-2527	NN	denotes	TLR
T6973	2514-2523	JJ	denotes	mammalian
T6972	2508-2513	JJ	denotes	first
T6971	2504-2507	DT	denotes	the
T6970	2502-2503	-COMMA-	denotes	,
T6969	2498-2502	NN	denotes	TLR4
T6968	2495-2496	-RRB-	denotes	]
T6967	2493-2495	CD	denotes	13
T6966	2491-2492	-COMMA-	denotes	,
T6965	2489-2491	CD	denotes	12
T6964	2488-2489	-LRB-	denotes	[
T6963	2483-2487	NN	denotes	NFκB
T6962	2480-2482	IN	denotes	of
T6961	2469-2479	NN	denotes	activation
T6960	2465-2468	DT	denotes	the
T6959	2455-2464	VB	denotes	stimulate
T6958	2448-2454	RB	denotes	mainly
T6957	2439-2447	NN	denotes	pathways
T6956	2429-2438	NN	denotes	signaling
T6955	2416-2428	JJ	denotes	TLR-mediated
T6954	2413-2414	-RRB-	denotes	]
T6953	2412-2413	CD	denotes	4
T6952	2411-2412	-LRB-	denotes	[
T6951	2402-2410	NN	denotes	immunity
T6950	2393-2401	JJ	denotes	adaptive
T6949	2389-2392	CC	denotes	and
T6948	2382-2388	JJ	denotes	innate
T6947	2379-2381	IN	denotes	of
T6946	2369-2378	NN	denotes	induction
T6945	2365-2368	DT	denotes	the
T6944	2362-2364	IN	denotes	in
T6943	2357-2361	NN	denotes	role
T6942	2348-2356	JJ	denotes	critical
T6941	2346-2347	DT	denotes	a
T6940	2341-2345	VB	denotes	play
T6939	2337-2340	CC	denotes	and
T6938	2327-2336	NN	denotes	molecules
T6937	2314-2326	NN	denotes	transduction
T6936	2307-2313	NN	denotes	signal
T6935	2304-2306	IN	denotes	of
T6934	2297-2303	NN	denotes	family
T6933	2295-2296	DT	denotes	a
T6932	2291-2294	VB	denotes	are
T6931	2289-2290	-RRB-	denotes	)
T6930	2285-2289	NN	denotes	TLRs
T6929	2284-2285	-LRB-	denotes	(
T6928	2274-2283	NN	denotes	receptors
T6927	2264-2273	JJ	denotes	Toll-like
T6926	2259-2262	NN	denotes	ICH
T6925	2255-2258	IN	denotes	for
T6924	2248-2254	NN	denotes	method
T6923	2232-2247	JJ	denotes	neuroprotective
T6922	2228-2231	JJ	denotes	new
T6921	2226-2227	DT	denotes	a
T6920	2218-2225	VB	denotes	seeking
T6919	2214-2217	IN	denotes	for
T6918	2205-2213	JJ	denotes	critical
T6917	2202-2204	VB	denotes	is
T6916	2198-2201	NN	denotes	ICH
T6915	2195-2197	TO	denotes	to
T6914	2185-2194	VB	denotes	subjected
T6913	2179-2184	NN	denotes	brain
T6912	2175-2178	DT	denotes	the
T6911	2172-2174	IN	denotes	in
T6910	2162-2171	VB	denotes	activated
T6909	2159-2161	VB	denotes	is
T6908	2154-2158	NN	denotes	NFκB
T6907	2150-2153	WRB	denotes	how
T6906	2144-2149	IN	denotes	about
T6905	2134-2143	NN	denotes	knowledge
T6904	2130-2133	DT	denotes	The
T6903	2127-2128	-RRB-	denotes	]
T6678	778-786	NN	denotes	reaction
T6686	823-830	JJ	denotes	capable
T6685	818-822	RB	denotes	also
T6684	814-817	VB	denotes	are
T6683	807-813	PRP	denotes	itself
T6682	801-806	NN	denotes	cells
T6681	795-800	NN	denotes	brain
T6680	791-794	DT	denotes	the
T6679	787-790	CC	denotes	and
T6677	765-777	JJ	denotes	inflammatory
T6676	762-764	DT	denotes	an
T6675	755-761	VB	denotes	induce
T6674	751-754	CC	denotes	and
T6673	745-750	NN	denotes	brain
T6672	741-744	DT	denotes	the
T6671	738-740	TO	denotes	to
T6670	732-737	VB	denotes	enter
T6669	726-731	MD	denotes	might
T6668	720-725	NN	denotes	blood
T6667	716-719	DT	denotes	the
T6666	711-715	IN	denotes	from
T6665	701-710	NN	denotes	mediators
T6664	688-700	JJ	denotes	inflammatory
T6663	686-687	-COMMA-	denotes	,
T6662	683-686	NN	denotes	ICH
T6661	677-682	IN	denotes	After
T6660	669-675	NN	denotes	events
T6659	653-668	JJ	denotes	cerebrovascular
T6658	650-652	IN	denotes	in
T6657	641-649	VB	denotes	involved
T6656	637-640	VB	denotes	are
T6655	627-636	NN	denotes	processes
T6654	614-626	JJ	denotes	inflammatory
T6653	609-613	IN	denotes	that
T6652	600-608	NN	denotes	evidence
T6651	589-599	VB	denotes	increasing
T6650	586-588	VB	denotes	is
T6649	580-585	EX	denotes	there
T6648	578-579	-COMMA-	denotes	,
T6647	570-578	NN	denotes	addition
T6646	567-569	IN	denotes	In
T6645	559-565	NN	denotes	damage
T6644	552-558	NN	denotes	tissue
T6643	546-551	NN	denotes	brain
T6642	539-545	VB	denotes	induce
T6641	535-538	NN	denotes	ICH
T6640	529-534	IN	denotes	after
T6639	518-528	NN	denotes	components
T6638	512-517	NN	denotes	blood
T6637	509-511	IN	denotes	of
T6636	500-508	NN	denotes	toxicity
T6635	496-499	CC	denotes	and
T6634	494-495	-COMMA-	denotes	,
T6633	486-494	NN	denotes	ischemia
T6632	484-485	-COMMA-	denotes	,
T6631	478-484	NN	denotes	effect
T6630	473-477	NNP	denotes	Mass
T6629	462-471	JJ	denotes	effective
T6628	458-461	RB	denotes	not
T6627	454-457	VB	denotes	are
T6626	450-453	NN	denotes	ICH
T6625	444-449	IN	denotes	after
T6624	437-443	NN	denotes	tissue
T6623	431-436	NN	denotes	brain
T6622	427-430	DT	denotes	the
T6621	424-426	IN	denotes	of
T6620	413-423	NN	denotes	protection
T6619	409-412	CC	denotes	and
T6618	401-408	NN	denotes	disease
T6617	396-400	DT	denotes	this
T6616	393-395	IN	denotes	of
T6615	383-392	NN	denotes	treatment
T6614	379-382	IN	denotes	for
T6613	372-378	NN	denotes	method
T6612	368-371	DT	denotes	the
T6611	366-367	-COMMA-	denotes	,
T6610	353-366	RB	denotes	Unfortunately
T6609	350-351	-RRB-	denotes	]
T6608	348-350	CD	denotes	10
T6607	347-348	-LRB-	denotes	[
T6606	342-346	NN	denotes	year
T6605	338-341	JJ	denotes	1st
T6604	334-337	DT	denotes	the
T6603	326-333	VB	denotes	survive
T6602	317-325	NN	denotes	patients
T6601	313-316	DT	denotes	the
T6600	310-312	IN	denotes	of
T6599	308-309	NN	denotes	%
T6598	306-308	CD	denotes	38
T6597	301-305	RB	denotes	Only
T6596	293-299	NN	denotes	months
T6595	291-292	CD	denotes	3
T6594	288-290	IN	denotes	at
T6593	276-287	JJ	denotes	independent
T6592	263-275	RB	denotes	functionally
T6591	259-262	VB	denotes	are
T6590	257-258	NN	denotes	%
T6589	255-257	CD	denotes	31
T6588	250-254	RB	denotes	Only
T6587	242-248	NN	denotes	stroke
R4719	T6548	T6547	arg1Of	hemorrhage,Intra-cerebral
R4720	T6548	T6549	arg1Of	hemorrhage,(
R4721	T6548	T6552	arg1Of	hemorrhage,represents
R4722	T6548	T6560	arg1Of	hemorrhage,occurs
R4723	T6550	T6549	arg2Of	ICH,(
R4724	T6551	T6549	arg3Of	),(
R4725	T6552	T6559	arg1Of	represents,and
R4726	T6554	T6552	arg2Of	%,represents
R4727	T6554	T6553	arg1Of	%,10–15
R4728	T6554	T6555	arg1Of	%,of
R4729	T6557	T6555	arg2Of	strokes,of
R4730	T6557	T6556	arg1Of	strokes,all
R4731	T6559	T6558	arg1Of	and,","
R4732	T6560	T6559	arg2Of	occurs,and
R4733	T6560	T6561	arg1Of	occurs,with
R4734	T6560	T6564	arg1Of	occurs,as
R4735	T6563	T6561	arg2Of	frequency,with
R4736	T6563	T6562	arg1Of	frequency,increasing
R4737	T6566	T6564	arg2Of	complication,as
R4738	T6566	T6565	arg1Of	complication,a
R4739	T6566	T6567	arg1Of	complication,of
R4740	T6570	T6567	arg2Of	treatment,of
R4741	T6570	T6568	arg1Of	treatment,the
R4742	T6570	T6569	arg1Of	treatment,thrombolytic
R4743	T6570	T6571	arg1Of	treatment,of
R4744	T6570	T6574	arg1Of	treatment,[
R4745	T6573	T6571	arg2Of	stroke,of
R4746	T6573	T6572	arg1Of	stroke,ischemic
R4747	T6575	T6574	arg2Of	1,[
R4748	T6576	T6574	arg3Of	],[
R4749	T6578	T6577	arg1Of	mortality,The
R4750	T6578	T6579	arg1Of	mortality,of
R4751	T6578	T6581	arg1Of	mortality,is
R4752	T6578	T6582	arg1Of	mortality,higher
R4753	T6580	T6579	arg2Of	ICH,of
R4754	T6582	T6581	arg2Of	higher,is
R4755	T6582	T6583	arg1Of	higher,than
R4756	T6584	T6583	arg2Of	that,than
R4757	T6584	T6585	arg1Of	that,of
R4758	T6587	T6585	arg2Of	stroke,of
R4759	T6587	T6586	arg1Of	stroke,ischemic
R4760	T6589	T6588	arg1Of	31,Only
R4761	T6590	T6589	arg1Of	%,31
R4762	T6590	T6591	arg1Of	%,are
R4763	T6590	T6593	arg1Of	%,independent
R4764	T6591	T6592	arg1Of	are,functionally
R4765	T6591	T6594	arg1Of	are,at
R4766	T6593	T6591	arg2Of	independent,are
R4767	T6596	T6594	arg2Of	months,at
R4768	T6596	T6595	arg1Of	months,3
R4769	T6598	T6597	arg1Of	38,Only
R4770	T6599	T6598	arg1Of	%,38
R4771	T6599	T6600	arg1Of	%,of
R4772	T6599	T6603	arg1Of	%,survive
R4773	T6602	T6600	arg2Of	patients,of
R4774	T6602	T6601	arg1Of	patients,the
R4775	T6603	T6607	arg1Of	survive,[
R4776	T6606	T6603	arg2Of	year,survive
R4777	T6606	T6604	arg1Of	year,the
R4778	T6606	T6605	arg1Of	year,1st
R4779	T6608	T6607	arg2Of	10,[
R4780	T6609	T6607	arg3Of	],[
R4781	T6613	T6612	arg1Of	method,the
R4782	T6613	T6614	arg1Of	method,for
R4783	T6613	T6627	arg1Of	method,are
R4784	T6613	T6629	arg1Of	method,effective
R4785	T6615	T6616	arg1Of	treatment,of
R4786	T6615	T6619	arg1Of	treatment,and
R4787	T6618	T6616	arg2Of	disease,of
R4788	T6618	T6617	arg1Of	disease,this
R4789	T6619	T6614	arg2Of	and,for
R4790	T6619	T6625	arg1Of	and,after
R4791	T6620	T6619	arg2Of	protection,and
R4792	T6620	T6621	arg1Of	protection,of
R4793	T6624	T6621	arg2Of	tissue,of
R4794	T6624	T6622	arg1Of	tissue,the
R4795	T6624	T6623	arg1Of	tissue,brain
R4796	T6626	T6625	arg2Of	ICH,after
R4797	T6627	T6610	arg1Of	are,Unfortunately
R4798	T6627	T6611	arg1Of	are,","
R4799	T6627	T6628	arg1Of	are,not
R4800	T6629	T6627	arg2Of	effective,are
R4801	T6631	T6630	arg1Of	effect,Mass
R4802	T6631	T6632	arg1Of	effect,","
R4803	T6632	T6635	arg1Of	",",and
R4804	T6633	T6632	arg2Of	ischemia,","
R4805	T6635	T6634	arg1Of	and,","
R4806	T6635	T6637	arg1Of	and,of
R4807	T6635	T6640	arg1Of	and,after
R4808	T6635	T6642	arg1Of	and,induce
R4809	T6636	T6635	arg2Of	toxicity,and
R4810	T6639	T6637	arg2Of	components,of
R4811	T6639	T6638	arg1Of	components,blood
R4812	T6641	T6640	arg2Of	ICH,after
R4813	T6645	T6642	arg2Of	damage,induce
R4814	T6645	T6643	arg1Of	damage,brain
R4815	T6645	T6644	arg1Of	damage,tissue
R4816	T6647	T6646	arg2Of	addition,In
R4817	T6649	T6650	arg1Of	there,is
R4818	T6650	T6646	arg1Of	is,In
R4819	T6650	T6648	arg1Of	is,","
R4820	T6652	T6650	arg2Of	evidence,is
R4821	T6652	T6651	arg1Of	evidence,increasing
R4822	T6655	T6654	arg1Of	processes,inflammatory
R4823	T6655	T6656	arg1Of	processes,are
R4824	T6655	T6657	arg2Of	processes,involved
R4825	T6657	T6652	arg2Of	involved,evidence
R4826	T6657	T6653	arg1Of	involved,that
R4827	T6657	T6656	arg2Of	involved,are
R4828	T6657	T6658	arg1Of	involved,in
R4829	T6660	T6658	arg2Of	events,in
R4830	T6660	T6659	arg1Of	events,cerebrovascular
R4831	T6662	T6661	arg2Of	ICH,After
R4832	T6665	T6664	arg1Of	mediators,inflammatory
R4833	T6665	T6666	arg1Of	mediators,from
R4834	T6665	T6669	arg1Of	mediators,might
R4835	T6665	T6670	arg1Of	mediators,enter
R4836	T6665	T6675	arg1Of	mediators,induce
R4837	T6668	T6666	arg2Of	blood,from
R4838	T6668	T6667	arg1Of	blood,the
R4839	T6670	T6671	arg1Of	enter,to
R4840	T6670	T6674	arg1Of	enter,and
R4841	T6673	T6671	arg2Of	brain,to
R4842	T6673	T6672	arg1Of	brain,the
R4843	T6674	T6669	arg2Of	and,might
R4844	T6674	T6679	arg1Of	and,and
R4845	T6675	T6674	arg2Of	induce,and
R4846	T6678	T6675	arg2Of	reaction,induce
R4847	T6678	T6676	arg1Of	reaction,an
R4848	T6678	T6677	arg1Of	reaction,inflammatory
R4849	T6679	T6661	arg1Of	and,After
R4850	T6679	T6663	arg1Of	and,","
R4851	T6682	T6680	arg1Of	cells,the
R4852	T6682	T6681	arg1Of	cells,brain
R4853	T6682	T6683	arg1Of	cells,itself
R4854	T6682	T6684	arg1Of	cells,are
R4855	T6682	T6686	arg1Of	cells,capable
R4856	T6682	T6688	arg1Of	cells,producing
R4857	T6684	T6679	arg2Of	are,and
R4858	T6684	T6685	arg1Of	are,also
R4859	T6686	T6684	arg2Of	capable,are
R4860	T6686	T6687	arg1Of	capable,of
R4861	T6688	T6687	arg2Of	producing,of
R4862	T6688	T6693	arg1Of	producing,[
R4863	T6689	T6688	arg2Of	many,producing
R4864	T6689	T6690	arg1Of	many,of
R4865	T6692	T6690	arg2Of	agents,of
R4866	T6692	T6691	arg1Of	agents,these
R4867	T6694	T6693	arg2Of	11,[
R4868	T6695	T6693	arg3Of	],[
R4869	T6698	T6696	arg1Of	responses,The
R4870	T6698	T6697	arg1Of	responses,inflammatory
R4871	T6698	T6699	arg1Of	responses,are
R4872	T6698	T6700	arg1Of	responses,responsible
R4873	T6700	T6699	arg2Of	responsible,are
R4874	T6700	T6701	arg1Of	responsible,for
R4875	T6704	T6703	arg1Of	induced,ICH
R4876	T6706	T6701	arg2Of	injury,for
R4877	T6706	T6702	arg1Of	injury,the
R4878	T6706	T6704	arg1Of	injury,induced
R4879	T6706	T6705	arg1Of	injury,brain
R4880	T6706	T6707	arg1Of	injury,","
R4881	T6706	T6708	arg1Of	injury,which
R4882	T6706	T6709	arg1Of	injury,could
R4883	T6706	T6710	arg1Of	injury,provide
R4884	T6710	T6709	arg2Of	provide,could
R4885	T6712	T6711	arg1Of	therapeutic,new
R4886	T6713	T6710	arg2Of	targets,provide
R4887	T6713	T6712	arg1Of	targets,therapeutic
R4888	T6713	T6714	arg1Of	targets,for
R4889	T6715	T6714	arg2Of	ICH,for
R4890	T6717	T6716	arg1Of	constituents,Various
R4891	T6717	T6718	arg1Of	constituents,of
R4892	T6717	T6722	arg1Of	constituents,","
R4893	T6717	T6723	arg1Of	constituents,including
R4894	T6717	T6733	arg1Of	constituents,and
R4895	T6721	T6718	arg2Of	response,of
R4896	T6721	T6719	arg1Of	response,the
R4897	T6721	T6720	arg1Of	response,inflammatory
R4898	T6725	T6724	arg1Of	molecules,adhesion
R4899	T6725	T6726	arg1Of	molecules,","
R4900	T6726	T6728	arg1Of	",",","
R4901	T6727	T6726	arg2Of	cytokines,","
R4902	T6728	T6730	arg1Of	",",","
R4903	T6729	T6728	arg2Of	leukocytes,","
R4904	T6730	T6723	arg2Of	",",including
R4905	T6731	T6730	arg2Of	immunoglobulins,","
R4906	T6733	T6732	arg1Of	and,","
R4907	T6733	T6736	arg1Of	and,may
R4908	T6733	T6737	arg1Of	and,be
R4909	T6733	T6738	arg1Of	and,important
R4910	T6734	T6733	arg2Of	complement,and
R4911	T6737	T6735	arg1Of	be,","
R4912	T6737	T6736	arg2Of	be,may
R4913	T6737	T6739	arg1Of	be,in
R4914	T6738	T6737	arg2Of	important,be
R4915	T6741	T6739	arg2Of	pathogenesis,in
R4916	T6741	T6740	arg1Of	pathogenesis,the
R4917	T6741	T6742	arg1Of	pathogenesis,of
R4918	T6743	T6742	arg2Of	ICH,of
R4919	T6746	T6760	arg1Of	how,is
R4920	T6746	T6761	arg1Of	how,unclear
R4921	T6749	T6747	arg1Of	responses,the
R4922	T6749	T6748	arg1Of	responses,inflammatory
R4923	T6749	T6750	arg1Of	responses,is
R4924	T6749	T6751	arg2Of	responses,activated
R4925	T6749	T6753	arg2Of	responses,regulated
R4926	T6751	T6752	arg1Of	activated,and
R4927	T6752	T6746	arg1Of	and,how
R4928	T6752	T6750	arg2Of	and,is
R4929	T6752	T6754	arg1Of	and,in
R4930	T6753	T6752	arg2Of	regulated,and
R4931	T6757	T6754	arg2Of	tissue,in
R4932	T6757	T6755	arg1Of	tissue,the
R4933	T6757	T6756	arg1Of	tissue,brain
R4934	T6757	T6758	arg1Of	tissue,after
R4935	T6759	T6758	arg2Of	ICH,after
R4936	T6760	T6744	arg1Of	is,However
R4937	T6760	T6745	arg1Of	is,","
R4938	T6761	T6760	arg2Of	unclear,is
R4939	T6765	T6762	arg1Of	factor-kappa-B,Transcription
R4940	T6765	T6763	arg1Of	factor-kappa-B,factor
R4941	T6765	T6764	arg1Of	factor-kappa-B,nuclear
R4942	T6765	T6766	arg1Of	factor-kappa-B,(
R4943	T6765	T6769	arg1Of	factor-kappa-B,is
R4944	T6767	T6766	arg2Of	NFκB,(
R4945	T6768	T6766	arg3Of	),(
R4946	T6774	T6769	arg2Of	factor,is
R4947	T6774	T6770	arg1Of	factor,an
R4948	T6774	T6771	arg1Of	factor,important
R4949	T6774	T6772	arg1Of	factor,nuclear
R4950	T6774	T6773	arg1Of	factor,transcription
R4951	T6774	T6775	arg1Of	factor,","
R4952	T6774	T6776	arg1Of	factor,which
R4953	T6774	T6777	arg1Of	factor,initiates
R4954	T6774	T6794	arg1Of	factor,plays
R4955	T6774	T6799	arg1Of	factor,regulating
R4956	T6777	T6792	arg1Of	initiates,and
R4957	T6778	T6777	arg2Of	transcription,initiates
R4958	T6778	T6779	arg1Of	transcription,of
R4959	T6780	T6779	arg2Of	genes,of
R4960	T6780	T6781	arg2Of	genes,associated
R4961	T6781	T6782	arg1Of	associated,with
R4962	T6781	T6787	arg1Of	associated,[
R4963	T6784	T6783	arg1Of	responses,immune
R4964	T6784	T6785	arg1Of	responses,and
R4965	T6785	T6782	arg2Of	and,with
R4966	T6786	T6785	arg2Of	inflammation,and
R4967	T6788	T6789	arg1Of	12,","
R4968	T6789	T6787	arg2Of	",",[
R4969	T6790	T6789	arg2Of	13,","
R4970	T6791	T6787	arg3Of	],[
R4971	T6794	T6792	arg2Of	plays,and
R4972	T6794	T6793	arg1Of	plays,also
R4973	T6794	T6798	arg1Of	plays,in
R4974	T6797	T6794	arg2Of	role,plays
R4975	T6797	T6795	arg1Of	role,a
R4976	T6797	T6796	arg1Of	role,key
R4977	T6799	T6798	arg2Of	regulating,in
R4978	T6799	T6801	arg1Of	regulating,in
R4979	T6800	T6799	arg2Of	inflammation,regulating
R4980	T6803	T6801	arg2Of	pathologies,in
R4981	T6803	T6802	arg1Of	pathologies,brain
R4982	T6804	T6805	arg1Of	It,has
R4983	T6804	T6806	arg1Of	It,been
R4984	T6804	T6807	arg2Of	It,reported
R4985	T6807	T6805	arg2Of	reported,has
R4986	T6807	T6806	arg2Of	reported,been
R4987	T6809	T6810	arg1Of	NFκB,increased
R4988	T6810	T6807	arg3Of	increased,reported
R4989	T6810	T6808	arg1Of	increased,that
R4990	T6810	T6811	arg1Of	increased,in
R4991	T6813	T6811	arg2Of	region,in
R4992	T6813	T6812	arg1Of	region,the
R4993	T6813	T6814	arg1Of	region,of
R4994	T6813	T6816	arg1Of	region,after
R4995	T6815	T6814	arg2Of	perihematoma,of
R4996	T6817	T6816	arg2Of	ICH,after
R4997	T6817	T6818	arg1Of	ICH,[
R4998	T6819	T6818	arg2Of	14,[
R4999	T6820	T6818	arg3Of	],[
R5000	T6822	T6821	arg1Of	activation,NFκB
R5001	T6822	T6823	arg1Of	activation,occurs
R5002	T6822	T6827	arg1Of	activation,persists
R5003	T6823	T6824	arg1Of	occurs,within
R5004	T6823	T6826	arg1Of	occurs,and
R5005	T6825	T6824	arg2Of	minutes,within
R5006	T6827	T6826	arg2Of	persists,and
R5007	T6827	T6828	arg1Of	persists,for
R5008	T6830	T6829	arg1Of	least,at
R5009	T6832	T6828	arg2Of	week,for
R5010	T6832	T6830	arg1Of	week,least
R5011	T6832	T6831	arg1Of	week,a
R5012	T6832	T6833	arg1Of	week,in
R5013	T6832	T6837	arg1Of	week,","
R5014	T6832	T6838	arg1Of	week,which
R5015	T6832	T6839	arg1Of	week,is
R5016	T6832	T6840	arg2Of	week,associated
R5017	T6833	T6835	arg1Of	in,to
R5018	T6834	T6833	arg2Of	response,in
R5019	T6836	T6833	arg3Of	ICH,in
R5020	T6840	T6839	arg2Of	associated,is
R5021	T6840	T6841	arg1Of	associated,with
R5022	T6843	T6841	arg2Of	expression,with
R5023	T6843	T6842	arg1Of	expression,the
R5024	T6843	T6844	arg1Of	expression,of
R5025	T6847	T6844	arg2Of	genes,of
R5026	T6847	T6845	arg2Of	genes,selected
R5027	T6847	T6846	arg1Of	genes,target
R5028	T6847	T6848	arg1Of	genes,[
R5029	T6849	T6848	arg2Of	15,[
R5030	T6850	T6848	arg3Of	],[
R5031	T6851	T6852	arg1Of	Activation,of
R5032	T6851	T6854	arg1Of	Activation,initiates
R5033	T6851	T6858	arg1Of	Activation,contributes
R5034	T6853	T6852	arg2Of	NFκB,of
R5035	T6854	T6857	arg1Of	initiates,and
R5036	T6856	T6854	arg2Of	responses,initiates
R5037	T6856	T6855	arg1Of	responses,inflammatory
R5038	T6857	T6868	arg1Of	and,[
R5039	T6858	T6857	arg2Of	contributes,and
R5040	T6858	T6859	arg1Of	contributes,to
R5041	T6858	T6866	arg1Of	contributes,after
R5042	T6861	T6859	arg2Of	pathobiology,to
R5043	T6861	T6860	arg1Of	pathobiology,the
R5044	T6861	T6862	arg1Of	pathobiology,of
R5045	T6865	T6862	arg2Of	death,of
R5046	T6865	T6863	arg1Of	death,perilesional
R5047	T6865	T6864	arg1Of	death,cell
R5048	T6867	T6866	arg2Of	ICH,after
R5049	T6869	T6868	arg2Of	16,[
R5050	T6870	T6868	arg3Of	],[
R5051	T6871	T6872	arg1Of	Inhibition,of
R5052	T6871	T6875	arg1Of	Inhibition,has
R5053	T6871	T6876	arg1Of	Inhibition,been
R5054	T6871	T6877	arg2Of	Inhibition,shown
R5055	T6871	T6879	arg1Of	Inhibition,have
R5056	T6874	T6872	arg2Of	activity,of
R5057	T6874	T6873	arg1Of	activity,NFκB
R5058	T6877	T6875	arg2Of	shown,has
R5059	T6877	T6876	arg2Of	shown,been
R5060	T6879	T6877	arg3Of	have,shown
R5061	T6879	T6878	arg1Of	have,to
R5062	T6882	T6879	arg2Of	effect,have
R5063	T6882	T6880	arg1Of	effect,a
R5064	T6882	T6881	arg1Of	effect,therapeutic
R5065	T6882	T6883	arg1Of	effect,on
R5066	T6882	T6886	arg1Of	effect,","
R5067	T6882	T6888	arg1Of	effect,as
R5068	T6885	T6883	arg2Of	ICH,on
R5069	T6885	T6884	arg1Of	ICH,experimental
R5070	T6888	T6887	arg1Of	as,such
R5071	T6890	T6889	arg1Of	inflammation,reduce
R5072	T6890	T6891	arg1Of	inflammation,","
R5073	T6891	T6895	arg1Of	",",and
R5074	T6893	T6891	arg2Of	dysfunction,","
R5075	T6893	T6892	arg1Of	dysfunction,behavioral
R5076	T6895	T6888	arg2Of	and,as
R5077	T6895	T6894	arg1Of	and,","
R5078	T6897	T6895	arg2Of	damage,and
R5079	T6897	T6896	arg1Of	damage,neuronal
R5080	T6897	T6898	arg2Of	damage,produced
R5081	T6898	T6901	arg1Of	produced,[
R5082	T6900	T6898	arg1Of	ICH,produced
R5083	T6900	T6899	arg2Of	ICH,by
R5084	T6902	T6901	arg2Of	17,[
R5085	T6903	T6901	arg3Of	],[
R5086	T6905	T6904	arg1Of	knowledge,The
R5087	T6905	T6906	arg1Of	knowledge,about
R5088	T6905	T6917	arg1Of	knowledge,is
R5089	T6905	T6918	arg1Of	knowledge,critical
R5090	T6907	T6906	arg2Of	how,about
R5091	T6908	T6909	arg1Of	NFκB,is
R5092	T6908	T6910	arg2Of	NFκB,activated
R5093	T6910	T6907	arg1Of	activated,how
R5094	T6910	T6909	arg2Of	activated,is
R5095	T6910	T6911	arg1Of	activated,in
R5096	T6913	T6911	arg2Of	brain,in
R5097	T6913	T6912	arg1Of	brain,the
R5098	T6913	T6914	arg2Of	brain,subjected
R5099	T6914	T6915	arg1Of	subjected,to
R5100	T6916	T6915	arg2Of	ICH,to
R5101	T6918	T6917	arg2Of	critical,is
R5102	T6918	T6919	arg1Of	critical,for
R5103	T6920	T6919	arg2Of	seeking,for
R5104	T6924	T6920	arg2Of	method,seeking
R5105	T6924	T6921	arg1Of	method,a
R5106	T6924	T6922	arg1Of	method,new
R5107	T6924	T6923	arg1Of	method,neuroprotective
R5108	T6924	T6925	arg1Of	method,for
R5109	T6926	T6925	arg2Of	ICH,for
R5110	T6928	T6927	arg1Of	receptors,Toll-like
R5111	T6928	T6929	arg1Of	receptors,(
R5112	T6928	T6932	arg1Of	receptors,are
R5113	T6928	T6940	arg1Of	receptors,play
R5114	T6930	T6929	arg2Of	TLRs,(
R5115	T6931	T6929	arg3Of	),(
R5116	T6932	T6939	arg1Of	are,and
R5117	T6934	T6932	arg2Of	family,are
R5118	T6934	T6933	arg1Of	family,a
R5119	T6934	T6935	arg1Of	family,of
R5120	T6938	T6935	arg2Of	molecules,of
R5121	T6938	T6936	arg1Of	molecules,signal
R5122	T6938	T6937	arg1Of	molecules,transduction
R5123	T6940	T6939	arg2Of	play,and
R5124	T6940	T6944	arg1Of	play,in
R5125	T6943	T6940	arg2Of	role,play
R5126	T6943	T6941	arg1Of	role,a
R5127	T6943	T6942	arg1Of	role,critical
R5128	T6946	T6944	arg2Of	induction,in
R5129	T6946	T6945	arg1Of	induction,the
R5130	T6946	T6947	arg1Of	induction,of
R5131	T6948	T6949	arg1Of	innate,and
R5132	T6950	T6949	arg2Of	adaptive,and
R5133	T6951	T6947	arg2Of	immunity,of
R5134	T6951	T6948	arg1Of	immunity,innate
R5135	T6951	T6950	arg1Of	immunity,adaptive
R5136	T6951	T6952	arg1Of	immunity,[
R5137	T6953	T6952	arg2Of	4,[
R5138	T6954	T6952	arg3Of	],[
R5139	T6957	T6955	arg1Of	pathways,TLR-mediated
R5140	T6957	T6956	arg1Of	pathways,signaling
R5141	T6957	T6959	arg1Of	pathways,stimulate
R5142	T6959	T6958	arg1Of	stimulate,mainly
R5143	T6959	T6964	arg1Of	stimulate,[
R5144	T6961	T6959	arg2Of	activation,stimulate
R5145	T6961	T6960	arg1Of	activation,the
R5146	T6961	T6962	arg1Of	activation,of
R5147	T6963	T6962	arg2Of	NFκB,of
R5148	T6965	T6964	arg2Of	12,[
R5149	T6965	T6966	arg1Of	12,","
R5150	T6967	T6966	arg2Of	13,","
R5151	T6968	T6964	arg3Of	],[
R5152	T6969	T6970	arg1Of	TLR4,","
R5153	T6969	T6977	arg1Of	TLR4,has
R5154	T6969	T6978	arg1Of	TLR4,been
R5155	T6969	T6979	arg2Of	TLR4,reported
R5156	T6969	T6981	arg1Of	TLR4,be
R5157	T6969	T6982	arg2Of	TLR4,involved
R5158	T6974	T6970	arg2Of	TLR,","
R5159	T6974	T6971	arg1Of	TLR,the
R5160	T6974	T6972	arg1Of	TLR,first
R5161	T6974	T6973	arg1Of	TLR,mammalian
R5162	T6974	T6975	arg2Of	TLR,recognized
R5163	T6979	T6976	arg1Of	reported,","
R5164	T6979	T6977	arg2Of	reported,has
R5165	T6979	T6978	arg2Of	reported,been
R5166	T6982	T6979	arg3Of	involved,reported
R5167	T6982	T6980	arg1Of	involved,to
R5168	T6982	T6981	arg2Of	involved,be
R5169	T6982	T6983	arg1Of	involved,in
R5170	T6986	T6985	arg1Of	nervous,central
R5171	T6986	T6987	arg1Of	nervous,(
R5172	T6988	T6987	arg2Of	CNS,(
R5173	T6989	T6987	arg3Of	),(
R5174	T6991	T6983	arg2Of	diseases,in
R5175	T6991	T6984	arg1Of	diseases,several
R5176	T6991	T6986	arg1Of	diseases,nervous
R5177	T6991	T6990	arg1Of	diseases,system
R5178	T6991	T6992	arg1Of	diseases,","
R5179	T6991	T6994	arg1Of	diseases,as
R5180	T6994	T6993	arg1Of	as,such
R5181	T6995	T6996	arg1Of	inflammatory,or
R5182	T6997	T6996	arg2Of	autoimmune,or
R5183	T6999	T6995	arg1Of	diseases,inflammatory
R5184	T6999	T6997	arg1Of	diseases,autoimmune
R5185	T6999	T6998	arg1Of	diseases,CNS
R5186	T6999	T7000	arg1Of	diseases,and
R5187	T7000	T6994	arg2Of	and,as
R5188	T7003	T7000	arg2Of	injury,and
R5189	T7003	T7001	arg1Of	injury,cerebral
R5190	T7003	T7002	arg1Of	injury,ischemic
R5191	T7003	T7004	arg1Of	injury,[
R5192	T7005	T7004	arg2Of	7,[
R5193	T7005	T7006	arg1Of	7,","
R5194	T7007	T7006	arg2Of	8,","
R5195	T7008	T7004	arg3Of	],[
R5196	T7011	T7010	arg1Of	reports,previous
R5197	T7011	T7012	arg1Of	reports,indicated
R5198	T7012	T7009	arg2Of	indicated,Although
R5199	T7015	T7014	arg1Of	activation,the
R5200	T7015	T7016	arg1Of	activation,of
R5201	T7015	T7018	arg1Of	activation,was
R5202	T7015	T7019	arg2Of	activation,attributed
R5203	T7017	T7016	arg2Of	NFκB,of
R5204	T7019	T7012	arg2Of	attributed,indicated
R5205	T7019	T7013	arg1Of	attributed,that
R5206	T7019	T7018	arg2Of	attributed,was
R5207	T7019	T7020	arg1Of	attributed,to
R5208	T7023	T7024	arg1Of	stress,or
R5209	T7025	T7024	arg2Of	glutamate,or
R5210	T7027	T7020	arg2Of	activation,to
R5211	T7027	T7021	arg1Of	activation,the
R5212	T7027	T7022	arg1Of	activation,oxidative
R5213	T7027	T7023	arg1Of	activation,stress
R5214	T7027	T7025	arg1Of	activation,glutamate
R5215	T7027	T7026	arg1Of	activation,receptor
R5216	T7027	T7028	arg2Of	activation,induced
R5217	T7032	T7030	arg1Of	cells,red
R5218	T7032	T7031	arg1Of	cells,blood
R5219	T7032	T7033	arg1Of	cells,and/or
R5220	T7033	T7028	arg1Of	and/or,induced
R5221	T7033	T7029	arg2Of	and/or,by
R5222	T7035	T7033	arg2Of	constituents,and/or
R5223	T7035	T7034	arg1Of	constituents,plasma
R5224	T7035	T7036	arg1Of	constituents,[
R5225	T7037	T7036	arg2Of	17,[
R5226	T7038	T7036	arg3Of	],[
R5227	T7041	T7040	arg1Of	few,very
R5228	T7042	T7041	arg1Of	studies,few
R5229	T7042	T7043	arg1Of	studies,have
R5230	T7042	T7044	arg1Of	studies,been
R5231	T7042	T7045	arg2Of	studies,directed
R5232	T7042	T7047	arg1Of	studies,investigate
R5233	T7045	T7009	arg1Of	directed,Although
R5234	T7045	T7039	arg1Of	directed,","
R5235	T7045	T7043	arg2Of	directed,have
R5236	T7045	T7044	arg2Of	directed,been
R5237	T7047	T7045	arg3Of	investigate,directed
R5238	T7047	T7046	arg1Of	investigate,to
R5239	T7049	T7048	arg1Of	role,the
R5240	T7049	T7050	arg1Of	role,and
R5241	T7050	T7047	arg2Of	and,investigate
R5242	T7052	T7050	arg2Of	relationship,and
R5243	T7052	T7051	arg1Of	relationship,the
R5244	T7052	T7053	arg1Of	relationship,between
R5245	T7056	T7057	arg1Of	signaling,and
R5246	T7057	T7053	arg2Of	and,between
R5247	T7057	T7054	arg1Of	and,TLR4-mediated
R5248	T7057	T7055	arg1Of	and,NFκB
R5249	T7058	T7057	arg2Of	ICH,and
R5250	T7062	T7059	arg2Of	study,In
R5251	T7062	T7060	arg1Of	study,the
R5252	T7062	T7061	arg1Of	study,present
R5253	T7064	T7065	arg1Of	we,established
R5254	T7064	T7073	arg1Of	we,detected
R5255	T7065	T7072	arg1Of	established,and
R5256	T7068	T7065	arg2Of	model,established
R5257	T7068	T7066	arg1Of	model,the
R5258	T7068	T7067	arg1Of	model,rat
R5259	T7068	T7069	arg1Of	model,of
R5260	T7071	T7069	arg2Of	ICH,of
R5261	T7071	T7070	arg1Of	ICH,experimental
R5262	T7072	T7059	arg1Of	and,In
R5263	T7072	T7063	arg1Of	and,","
R5264	T7073	T7072	arg2Of	detected,and
R5265	T7076	T7077	arg1Of	mRNA,and
R5266	T7077	T7073	arg2Of	and,detected
R5267	T7077	T7074	arg1Of	and,the
R5268	T7077	T7075	arg1Of	and,TLR4
R5269	T7078	T7077	arg2Of	protein,and
R5270	T7080	T7079	arg1Of	data,Our
R5271	T7080	T7081	arg1Of	data,showed
R5272	T7083	T7084	arg1Of	transcription,of
R5273	T7083	T7088	arg1Of	transcription,as
R5274	T7085	T7084	arg2Of	TLR4,of
R5275	T7088	T7086	arg1Of	as,as
R5276	T7088	T7087	arg1Of	as,well
R5277	T7088	T7097	arg2Of	as,elevated
R5278	T7090	T7088	arg2Of	expression,as
R5279	T7090	T7089	arg1Of	expression,the
R5280	T7090	T7091	arg1Of	expression,of
R5281	T7093	T7091	arg2Of	protein,of
R5282	T7093	T7092	arg1Of	protein,TLR4
R5283	T7093	T7094	arg1Of	protein,after
R5284	T7095	T7094	arg2Of	ICH,after
R5285	T7097	T7081	arg2Of	elevated,showed
R5286	T7097	T7082	arg1Of	elevated,that
R5287	T7097	T7096	arg1Of	elevated,significantly
R5288	T7097	T7098	arg1Of	elevated,in
R5289	T7100	T7098	arg2Of	tissue,in
R5290	T7100	T7099	arg1Of	tissue,brain
R5291	T7102	T7101	arg1Of	changes,These
R5292	T7102	T7103	arg1Of	changes,started
R5293	T7102	T7114	arg1Of	changes,maintained
R5294	T7103	T7105	arg1Of	started,early
R5295	T7103	T7109	arg1Of	started,after
R5296	T7103	T7113	arg1Of	started,and
R5297	T7105	T7104	arg1Of	early,as
R5298	T7105	T7106	arg1Of	early,as
R5299	T7108	T7106	arg2Of	hours,as
R5300	T7108	T7107	arg1Of	hours,6
R5301	T7112	T7109	arg2Of	insult,after
R5302	T7112	T7110	arg1Of	insult,the
R5303	T7112	T7111	arg1Of	insult,ICH
R5304	T7114	T7113	arg2Of	maintained,and
R5305	T7114	T7115	arg1Of	maintained,at
R5306	T7114	T7119	arg1Of	maintained,for
R5307	T7118	T7115	arg2Of	level,at
R5308	T7118	T7116	arg1Of	level,a
R5309	T7118	T7117	arg1Of	level,high
R5310	T7121	T7119	arg2Of	days,for
R5311	T7121	T7120	arg1Of	days,7
R5312	T7121	T7122	arg1Of	days,afterward
R5313	T7125	T7123	arg1Of	protein,The
R5314	T7125	T7124	arg1Of	protein,TLR4
R5315	T7125	T7126	arg1Of	protein,","
R5316	T7125	T7127	arg2Of	protein,detected
R5317	T7125	T7131	arg1Of	protein,was
R5318	T7125	T7133	arg2Of	protein,distributed
R5319	T7129	T7127	arg1Of	immunohistochemistry,detected
R5320	T7129	T7128	arg2Of	immunohistochemistry,by
R5321	T7133	T7130	arg1Of	distributed,","
R5322	T7133	T7131	arg2Of	distributed,was
R5323	T7133	T7132	arg1Of	distributed,consistently
R5324	T7133	T7134	arg1Of	distributed,in
R5325	T7136	T7135	arg1Of	areas,peri-hemorrhage
R5326	T7136	T7137	arg1Of	areas,","
R5327	T7136	T7146	arg1Of	areas,and
R5328	T7139	T7138	arg1Of	hippocampus,the
R5329	T7139	T7140	arg1Of	hippocampus,","
R5330	T7139	T7142	arg1Of	hippocampus,","
R5331	T7141	T7140	arg2Of	cortex,","
R5332	T7142	T7137	arg2Of	",",","
R5333	T7144	T7142	arg2Of	nuclei,","
R5334	T7144	T7143	arg1Of	nuclei,thalamic
R5335	T7146	T7134	arg2Of	and,in
R5336	T7146	T7145	arg1Of	and,","
R5337	T7150	T7146	arg2Of	tracts,and
R5338	T7150	T7147	arg1Of	tracts,some
R5339	T7150	T7148	arg1Of	tracts,white
R5340	T7150	T7149	arg1Of	tracts,matter
R5341	T7152	T7151	arg1Of	data,These
R5342	T7152	T7153	arg1Of	data,indicated
R5343	T7156	T7155	arg2Of	expression,increased
R5344	T7156	T7157	arg1Of	expression,of
R5345	T7156	T7159	arg1Of	expression,may
R5346	T7156	T7160	arg1Of	expression,be
R5347	T7156	T7161	arg1Of	expression,related
R5348	T7158	T7157	arg2Of	TLR4,of
R5349	T7160	T7153	arg2Of	be,indicated
R5350	T7160	T7154	arg1Of	be,that
R5351	T7160	T7159	arg2Of	be,may
R5352	T7161	T7160	arg2Of	related,be
R5353	T7161	T7162	arg1Of	related,to
R5354	T7164	T7162	arg2Of	triggering,to
R5355	T7164	T7163	arg1Of	triggering,the
R5356	T7164	T7165	arg1Of	triggering,of
R5357	T7168	T7165	arg2Of	responses,of
R5358	T7168	T7166	arg1Of	responses,the
R5359	T7168	T7167	arg1Of	responses,inflammatory
R5360	T7168	T7169	arg1Of	responses,in
R5361	T7172	T7169	arg2Of	tissue,in
R5362	T7172	T7170	arg1Of	tissue,the
R5363	T7172	T7171	arg1Of	tissue,brain
R5364	T7172	T7173	arg1Of	tissue,after
R5365	T7174	T7173	arg2Of	ICH,after
R5366	T7176	T7175	arg1Of	studies,Recent
R5367	T7176	T7177	arg1Of	studies,demonstrated
R5368	T7179	T7180	arg1Of	ICH,initiates
R5369	T7180	T7177	arg2Of	initiates,demonstrated
R5370	T7180	T7178	arg1Of	initiates,that
R5371	T7182	T7180	arg2Of	responses,initiates
R5372	T7182	T7181	arg1Of	responses,inflammatory
R5373	T7182	T7183	arg1Of	responses,","
R5374	T7182	T7184	arg1Of	responses,which
R5375	T7182	T7185	arg1Of	responses,are
R5376	T7182	T7186	arg2Of	responses,associated
R5377	T7186	T7185	arg2Of	associated,are
R5378	T7186	T7187	arg1Of	associated,with
R5379	T7189	T7188	arg1Of	growth,secondary
R5380	T7189	T7190	arg1Of	growth,of
R5381	T7189	T7192	arg1Of	growth,and
R5382	T7191	T7190	arg2Of	hemorrhage,of
R5383	T7192	T7187	arg2Of	and,with
R5384	T7194	T7192	arg2Of	death,and
R5385	T7194	T7193	arg1Of	death,cell
R5386	T7194	T7195	arg1Of	death,[
R5387	T7196	T7195	arg2Of	18,[
R5388	T7197	T7195	arg3Of	],[
R5389	T7198	T7199	arg1Of	It,is
R5390	T7198	T7201	arg2Of	It,believed
R5391	T7201	T7199	arg2Of	believed,is
R5392	T7201	T7200	arg1Of	believed,now
R5393	T7204	T7203	arg1Of	pathway,TLR4-mediated-NFκB
R5394	T7204	T7205	arg1Of	pathway,activates
R5395	T7204	T7207	arg1Of	pathway,regulates
R5396	T7205	T7206	arg1Of	activates,and
R5397	T7206	T7201	arg3Of	and,believed
R5398	T7206	T7202	arg1Of	and,that
R5399	T7207	T7206	arg2Of	regulates,and
R5400	T7208	T7209	arg1Of	immunological,and
R5401	T7210	T7209	arg2Of	inflammatory,and
R5402	T7211	T7205	arg2Of	responses,activates
R5403	T7211	T7207	arg2Of	responses,regulates
R5404	T7211	T7208	arg1Of	responses,immunological
R5405	T7211	T7210	arg1Of	responses,inflammatory
R5406	T7213	T7212	arg1Of	investigate,To
R5407	T7213	T7221	arg1Of	investigate,in
R5408	T7215	T7213	arg2Of	mechanisms,investigate
R5409	T7215	T7214	arg1Of	mechanisms,the
R5410	T7215	T7216	arg1Of	mechanisms,underlying
R5411	T7220	T7216	arg2Of	responses,underlying
R5412	T7220	T7217	arg1Of	responses,the
R5413	T7220	T7218	arg2Of	responses,increased
R5414	T7220	T7219	arg1Of	responses,inflammatory
R5415	T7223	T7221	arg2Of	brain,in
R5416	T7223	T7222	arg1Of	brain,the
R5417	T7223	T7224	arg1Of	brain,after
R5418	T7225	T7224	arg2Of	ICH,after
R5419	T7230	T7227	arg2Of	study,in
R5420	T7230	T7228	arg1Of	study,the
R5421	T7230	T7229	arg1Of	study,present
R5422	T7232	T7213	arg1Of	we,investigate
R5423	T7232	T7233	arg1Of	we,evaluated
R5424	T7232	T7241	arg1Of	we,detecting
R5425	T7233	T7212	modOf	evaluated,To
R5426	T7233	T7226	arg1Of	evaluated,","
R5427	T7233	T7227	arg1Of	evaluated,in
R5428	T7233	T7231	arg1Of	evaluated,","
R5429	T7233	T7240	arg1Of	evaluated,by
R5430	T7235	T7233	arg2Of	activation,evaluated
R5431	T7235	T7234	arg1Of	activation,the
R5432	T7235	T7236	arg1Of	activation,of
R5433	T7239	T7236	arg2Of	signaling,of
R5434	T7239	T7237	arg1Of	signaling,TLR4-mediated
R5435	T7239	T7238	arg1Of	signaling,NFκB
R5436	T7241	T7240	arg2Of	detecting,by
R5437	T7241	T7249	arg1Of	detecting,in
R5438	T7243	T7242	arg1Of	p-IκB,the
R5439	T7243	T7244	arg1Of	p-IκB,and
R5440	T7244	T7241	arg2Of	and,detecting
R5441	T7246	T7244	arg2Of	activity,and
R5442	T7246	T7245	arg1Of	activity,the
R5443	T7246	T7247	arg1Of	activity,of
R5444	T7248	T7247	arg2Of	NFκB,of
R5445	T7251	T7249	arg2Of	brains,in
R5446	T7251	T7250	arg1Of	brains,hemorrhagic
R5447	T7252	T7253	arg1Of	NFκB,is
R5448	T7253	T7258	arg1Of	is,downstream
R5449	T7253	T7259	arg1Of	is,in
R5450	T7257	T7253	arg2Of	factor,is
R5451	T7257	T7254	arg1Of	factor,an
R5452	T7257	T7255	arg1Of	factor,important
R5453	T7257	T7256	arg1Of	factor,transcription
R5454	T7263	T7259	arg2Of	pathway,in
R5455	T7263	T7260	arg1Of	pathway,the
R5456	T7263	T7261	arg1Of	pathway,TLR4-mediated
R5457	T7263	T7262	arg1Of	pathway,signaling
R5458	T7264	T7265	arg1Of	Activation,of
R5459	T7264	T7267	arg1Of	Activation,stimulates
R5460	T7266	T7265	arg2Of	TLR4,of
R5461	T7267	T7272	arg1Of	stimulates,","
R5462	T7267	T7273	modOf	stimulates,resulting
R5463	T7269	T7270	arg1Of	phosphorylation,and
R5464	T7270	T7267	arg2Of	and,stimulates
R5465	T7270	T7268	arg1Of	and,IκBα
R5466	T7271	T7270	arg2Of	degradation,and
R5467	T7273	T7274	arg1Of	resulting,in
R5468	T7276	T7274	arg2Of	translocation,in
R5469	T7276	T7275	arg1Of	translocation,nuclear
R5470	T7276	T7277	arg1Of	translocation,of
R5471	T7276	T7279	arg1Of	translocation,","
R5472	T7276	T7280	arg1Of	translocation,which
R5473	T7276	T7281	arg1Of	translocation,initiates
R5474	T7278	T7277	arg2Of	NFκB,of
R5475	T7282	T7281	arg2Of	transcription,initiates
R5476	T7282	T7283	arg1Of	transcription,of
R5477	T7284	T7285	arg2Of	genes,associated
R5478	T7284	T7290	arg1Of	genes,and
R5479	T7285	T7286	arg1Of	associated,with
R5480	T7289	T7286	arg2Of	responses,with
R5481	T7289	T7287	arg1Of	responses,innate
R5482	T7289	T7288	arg1Of	responses,immune
R5483	T7290	T7283	arg2Of	and,of
R5484	T7291	T7290	arg2Of	inflammation,and
R5485	T7291	T7292	arg1Of	inflammation,[
R5486	T7293	T7292	arg2Of	5,[
R5487	T7293	T7294	arg1Of	5,","
R5488	T7295	T7294	arg2Of	6,","
R5489	T7296	T7292	arg3Of	],[
R5490	T7297	T7298	arg1Of	We,observed
R5491	T7301	T7300	arg1Of	levels,the
R5492	T7301	T7302	arg1Of	levels,of
R5493	T7301	T7311	arg1Of	levels,were
R5494	T7301	T7313	arg2Of	levels,increased
R5495	T7303	T7304	arg1Of	phosphorylation,of
R5496	T7303	T7306	arg1Of	phosphorylation,and
R5497	T7305	T7304	arg2Of	IκB,of
R5498	T7306	T7302	arg2Of	and,of
R5499	T7308	T7306	arg2Of	activity,and
R5500	T7308	T7307	arg1Of	activity,the
R5501	T7308	T7309	arg1Of	activity,of
R5502	T7310	T7309	arg2Of	NFκB,of
R5503	T7313	T7298	arg2Of	increased,observed
R5504	T7313	T7299	arg1Of	increased,that
R5505	T7313	T7311	arg2Of	increased,were
R5506	T7313	T7312	arg1Of	increased,significantly
R5507	T7313	T7314	arg1Of	increased,in
R5508	T7316	T7314	arg2Of	tissue,in
R5509	T7316	T7315	arg1Of	tissue,brain
R5510	T7316	T7317	arg1Of	tissue,after
R5511	T7318	T7317	arg2Of	ICH,after
R5512	T7321	T7319	arg1Of	profile,The
R5513	T7321	T7320	arg1Of	profile,temporal
R5514	T7321	T7322	arg1Of	profile,of
R5515	T7321	T7327	arg1Of	profile,and
R5516	T7324	T7322	arg2Of	expression,of
R5517	T7324	T7323	arg1Of	expression,the
R5518	T7324	T7325	arg1Of	expression,of
R5519	T7326	T7325	arg2Of	p-IκB,of
R5520	T7327	T7332	arg1Of	and,was
R5521	T7327	T7333	arg1Of	and,similar
R5522	T7329	T7327	arg2Of	activation,and
R5523	T7329	T7328	arg1Of	activation,the
R5524	T7329	T7330	arg1Of	activation,of
R5525	T7331	T7330	arg2Of	NFκB,of
R5526	T7333	T7332	arg2Of	similar,was
R5527	T7333	T7334	arg1Of	similar,to
R5528	T7335	T7334	arg2Of	that,to
R5529	T7335	T7336	arg1Of	that,of
R5530	T7338	T7336	arg2Of	expression,of
R5531	T7338	T7337	arg1Of	expression,the
R5532	T7338	T7339	arg1Of	expression,of
R5533	T7340	T7339	arg2Of	TLR4,of
R5534	T7342	T7341	arg1Of	data,Our
R5535	T7342	T7343	arg1Of	data,suggest
R5536	T7345	T7346	arg1Of	ICH,stimulates
R5537	T7346	T7343	arg2Of	stimulates,suggest
R5538	T7346	T7344	arg1Of	stimulates,that
R5539	T7347	T7346	arg2Of	activation,stimulates
R5540	T7347	T7348	arg1Of	activation,of
R5541	T7352	T7348	arg2Of	pathway,of
R5542	T7352	T7349	arg1Of	pathway,the
R5543	T7352	T7350	arg1Of	pathway,TLR4/NFκB
R5544	T7352	T7351	arg1Of	pathway,signaling
R5545	T7352	T7353	arg1Of	pathway,","
R5546	T7352	T7354	arg1Of	pathway,which
R5547	T7352	T7355	arg1Of	pathway,is
R5548	T7352	T7356	arg1Of	pathway,consistent
R5549	T7356	T7355	arg2Of	consistent,is
R5550	T7356	T7357	arg1Of	consistent,with
R5551	T7359	T7357	arg2Of	reports,with
R5552	T7359	T7358	arg1Of	reports,previous
R5553	T7361	T7362	arg1Of	activation,of
R5554	T7361	T7364	arg1Of	activation,is
R5555	T7361	T7365	arg2Of	activation,regulated
R5556	T7363	T7362	arg2Of	NFκB,of
R5557	T7365	T7359	arg2Of	regulated,reports
R5558	T7365	T7360	arg1Of	regulated,that
R5559	T7365	T7364	arg2Of	regulated,is
R5560	T7365	T7366	arg1Of	regulated,through
R5561	T7370	T7366	arg2Of	pathway,through
R5562	T7370	T7367	arg1Of	pathway,the
R5563	T7370	T7368	arg1Of	pathway,TLR4-mediated
R5564	T7370	T7369	arg1Of	pathway,signaling
R5565	T7371	T7372	arg1Of	TLR4,plays
R5566	T7371	T7388	arg1Of	TLR4,can
R5567	T7371	T7390	arg1Of	TLR4,recognize
R5568	T7372	T7376	arg1Of	plays,in
R5569	T7372	T7382	arg1Of	plays,[
R5570	T7372	T7387	arg1Of	plays,and
R5571	T7375	T7372	arg2Of	role,plays
R5572	T7375	T7373	arg1Of	role,an
R5573	T7375	T7374	arg1Of	role,important
R5574	T7378	T7376	arg2Of	recognition,in
R5575	T7378	T7377	arg1Of	recognition,the
R5576	T7378	T7379	arg1Of	recognition,of
R5577	T7381	T7379	arg2Of	components,of
R5578	T7381	T7380	arg1Of	components,microbial
R5579	T7383	T7384	arg1Of	19,","
R5580	T7384	T7382	arg2Of	",",[
R5581	T7385	T7384	arg2Of	20,","
R5582	T7386	T7382	arg3Of	],[
R5583	T7390	T7387	arg2Of	recognize,and
R5584	T7390	T7388	arg2Of	recognize,can
R5585	T7390	T7389	arg1Of	recognize,also
R5586	T7392	T7391	arg1Of	molecules,endogenous
R5587	T7392	T7394	arg1Of	molecules,as
R5588	T7392	T7405	arg1Of	molecules,","
R5589	T7394	T7393	arg1Of	as,such
R5590	T7397	T7394	arg2Of	products,as
R5591	T7397	T7395	arg1Of	products,the
R5592	T7397	T7396	arg1Of	products,degradation
R5593	T7397	T7398	arg1Of	products,of
R5594	T7397	T7400	arg1Of	products,","
R5595	T7399	T7398	arg2Of	macromolecules,of
R5596	T7401	T7400	arg2Of	products,","
R5597	T7401	T7402	arg1Of	products,of
R5598	T7404	T7402	arg2Of	cascades,of
R5599	T7404	T7403	arg1Of	cascades,proteolytic
R5600	T7405	T7412	arg1Of	",",and
R5601	T7407	T7405	arg2Of	components,","
R5602	T7407	T7406	arg1Of	components,intracellular
R5603	T7407	T7408	arg1Of	components,of
R5604	T7410	T7408	arg2Of	cells,of
R5605	T7410	T7409	arg1Of	cells,ruptured
R5606	T7412	T7390	arg2Of	and,recognize
R5607	T7412	T7411	arg1Of	and,","
R5608	T7413	T7412	arg2Of	products,and
R5609	T7413	T7414	arg1Of	products,of
R5610	T7415	T7414	arg2Of	genes,of
R5611	T7415	T7416	arg1Of	genes,that
R5612	T7415	T7417	arg1Of	genes,are
R5613	T7415	T7418	arg2Of	genes,activated
R5614	T7418	T7417	arg2Of	activated,are
R5615	T7420	T7418	arg1Of	inflammation,activated
R5616	T7420	T7419	arg2Of	inflammation,by
R5617	T7422	T7421	arg2Of	instance,For
R5618	T7424	T7425	arg1Of	HSP70,","
R5619	T7425	T7427	arg1Of	",",","
R5620	T7426	T7425	arg2Of	HSP32,","
R5621	T7427	T7430	arg1Of	",",and
R5622	T7428	T7427	arg2Of	HSP27,","
R5623	T7430	T7429	arg1Of	and,","
R5624	T7430	T7436	arg1Of	and,are
R5625	T7430	T7437	arg2Of	and,found
R5626	T7430	T7439	arg1Of	and,be
R5627	T7430	T7440	arg2Of	and,upregulated
R5628	T7431	T7430	arg2Of	enzymes,and
R5629	T7431	T7432	arg2Of	enzymes,involved
R5630	T7432	T7433	arg1Of	involved,in
R5631	T7435	T7433	arg2Of	stress,in
R5632	T7435	T7434	arg1Of	stress,oxidative
R5633	T7437	T7421	arg1Of	found,For
R5634	T7437	T7423	arg1Of	found,","
R5635	T7437	T7436	arg2Of	found,are
R5636	T7440	T7437	arg3Of	upregulated,found
R5637	T7440	T7438	arg1Of	upregulated,to
R5638	T7440	T7439	arg2Of	upregulated,be
R5639	T7440	T7441	arg1Of	upregulated,in
R5640	T7443	T7441	arg2Of	brain,in
R5641	T7443	T7442	arg1Of	brain,the
R5642	T7443	T7444	arg1Of	brain,after
R5643	T7443	T7446	arg1Of	brain,","
R5644	T7443	T7447	arg1Of	brain,which
R5645	T7443	T7448	arg1Of	brain,may
R5646	T7443	T7449	arg1Of	brain,be
R5647	T7443	T7450	arg2Of	brain,produced
R5648	T7445	T7444	arg2Of	ICH,after
R5649	T7450	T7448	arg2Of	produced,may
R5650	T7450	T7449	arg2Of	produced,be
R5651	T7454	T7452	arg2Of	cells,injured
R5652	T7454	T7453	arg1Of	cells,neuronal
R5653	T7454	T7455	arg1Of	cells,or
R5654	T7455	T7450	arg1Of	or,produced
R5655	T7455	T7451	arg2Of	or,by
R5656	T7457	T7455	arg2Of	cells,or
R5657	T7457	T7456	arg1Of	cells,blood
R5658	T7457	T7458	arg1Of	cells,[
R5659	T7459	T7458	arg2Of	21,[
R5660	T7460	T7458	arg3Of	],[
R5661	T7467	T7466	arg1Of	molecules,these
R5662	T7467	T7468	arg2Of	molecules,produced
R5663	T7467	T7473	arg1Of	molecules,came
R5664	T7467	T7487	arg1Of	molecules,activate
R5665	T7468	T7469	arg1Of	produced,in
R5666	T7471	T7469	arg2Of	brain,in
R5667	T7471	T7470	arg2Of	brain,damaged
R5668	T7471	T7472	arg1Of	brain,or
R5669	T7473	T7474	arg1Of	came,from
R5670	T7473	T7482	arg1Of	came,as
R5671	T7473	T7486	arg1Of	came,","
R5672	T7476	T7475	arg1Of	cells,blood
R5673	T7476	T7477	arg1Of	cells,and
R5674	T7477	T7474	arg2Of	and,from
R5675	T7478	T7477	arg2Of	constituents,and
R5676	T7478	T7479	arg1Of	constituents,of
R5677	T7481	T7479	arg2Of	server,of
R5678	T7481	T7480	arg1Of	server,plasma
R5679	T7485	T7482	arg2Of	ligands,as
R5680	T7485	T7483	arg1Of	ligands,endogenous
R5681	T7485	T7484	arg1Of	ligands,TLR4
R5682	T7486	T7464	arg2Of	",",speculated
R5683	T7486	T7465	arg1Of	",",that
R5684	T7487	T7486	arg2Of	activate,","
R5685	T7490	T7487	arg2Of	signaling,activate
R5686	T7490	T7488	arg1Of	signaling,TLR4-mediated
R5687	T7490	T7489	arg1Of	signaling,NFκB
R5688	T7492	T7491	arg1Of	and,","
R5689	T7493	T7492	arg2Of	initiate,and
R5690	T7496	T7493	arg2Of	responses,initiate
R5691	T7496	T7494	arg1Of	responses,the
R5692	T7496	T7495	arg1Of	responses,inflammatory
R5693	T7496	T7497	arg1Of	responses,in
R5694	T7499	T7497	arg2Of	brain,in
R5695	T7499	T7498	arg1Of	brain,IHC
R5696	T7505	T7502	arg1Of	ligands,the
R5697	T7505	T7503	arg1Of	ligands,specific
R5698	T7505	T7504	arg1Of	ligands,endogenous
R5699	T7505	T7506	arg1Of	ligands,for
R5700	T7505	T7511	arg1Of	ligands,have
R5701	T7505	T7513	arg1Of	ligands,been
R5702	T7505	T7514	arg2Of	ligands,determined
R5703	T7505	T7516	arg1Of	ligands,need
R5704	T7505	T7518	arg1Of	ligands,be
R5705	T7505	T7519	arg2Of	ligands,identified
R5706	T7507	T7506	arg2Of	TLR4,for
R5707	T7507	T7508	arg1Of	TLR4,in
R5708	T7510	T7508	arg2Of	brain,in
R5709	T7510	T7509	arg1Of	brain,hemorrhagic
R5710	T7514	T7511	arg2Of	determined,have
R5711	T7514	T7512	arg1Of	determined,not
R5712	T7514	T7513	arg2Of	determined,been
R5713	T7514	T7515	arg1Of	determined,and
R5714	T7515	T7500	arg1Of	and,However
R5715	T7515	T7501	arg1Of	and,","
R5716	T7516	T7515	arg2Of	need,and
R5717	T7519	T7516	arg2Of	identified,need
R5718	T7519	T7517	arg1Of	identified,to
R5719	T7519	T7518	arg2Of	identified,be
R5720	T7519	T7520	arg1Of	identified,through
R5721	T7522	T7520	arg2Of	research,through
R5722	T7522	T7521	arg1Of	research,further
R5723	T7524	T7523	arg2Of	conclusion,In
R5724	T7528	T7526	arg1Of	study,the
R5725	T7528	T7527	arg1Of	study,present
R5726	T7528	T7529	arg1Of	study,demonstrated
R5727	T7529	T7523	arg1Of	demonstrated,In
R5728	T7529	T7525	arg1Of	demonstrated,","
R5729	T7532	T7529	arg2Of	profile,demonstrated
R5730	T7532	T7530	arg1Of	profile,the
R5731	T7532	T7531	arg1Of	profile,temporal
R5732	T7532	T7533	arg1Of	profile,of
R5733	T7535	T7533	arg2Of	activation,of
R5734	T7535	T7534	arg1Of	activation,the
R5735	T7535	T7536	arg1Of	activation,of
R5736	T7535	T7540	arg1Of	activation,in
R5737	T7535	T7543	arg1Of	activation,in
R5738	T7535	T7550	arg1Of	activation,","
R5739	T7535	T7551	arg1Of	activation,which
R5740	T7535	T7552	arg1Of	activation,suggests
R5741	T7539	T7536	arg2Of	signaling,of
R5742	T7539	T7537	arg1Of	signaling,TLR4-mediated
R5743	T7539	T7538	arg1Of	signaling,NFκB
R5744	T7542	T7540	arg2Of	tissue,in
R5745	T7542	T7541	arg1Of	tissue,brain
R5746	T7546	T7543	arg2Of	model,in
R5747	T7546	T7544	arg1Of	model,a
R5748	T7546	T7545	arg1Of	model,rat
R5749	T7546	T7547	arg1Of	model,of
R5750	T7549	T7547	arg2Of	ICH,of
R5751	T7549	T7548	arg1Of	ICH,experimental
R5752	T7556	T7554	arg1Of	signaling,TLR4-mediated
R5753	T7556	T7555	arg1Of	signaling,NFκB
R5754	T7556	T7557	arg1Of	signaling,participates
R5755	T7557	T7552	arg2Of	participates,suggests
R5756	T7557	T7553	arg1Of	participates,that
R5757	T7557	T7558	arg1Of	participates,in
R5758	T7560	T7558	arg2Of	pathogenesis,in
R5759	T7560	T7559	arg1Of	pathogenesis,the
R5760	T7560	T7561	arg1Of	pathogenesis,of
R5761	T7560	T7563	arg1Of	pathogenesis,","
R5762	T7560	T7564	arg1Of	pathogenesis,which
R5763	T7560	T7565	arg1Of	pathogenesis,may
R5764	T7560	T7566	arg1Of	pathogenesis,be
R5765	T7562	T7561	arg2Of	ICH,of
R5766	T7566	T7565	arg2Of	be,may
R5767	T7569	T7566	arg2Of	target,be
R5768	T7569	T7567	arg1Of	target,a
R5769	T7569	T7568	arg1Of	target,therapeutic
R5770	T7569	T7570	arg1Of	target,for
R5771	T7572	T7570	arg2Of	prevention,for
R5772	T7572	T7571	arg1Of	prevention,the
R5773	T7572	T7573	arg1Of	prevention,of
R5774	T7576	T7573	arg2Of	damage,of
R5775	T7576	T7574	arg1Of	damage,ICH-induced
R5776	T7576	T7575	arg1Of	damage,brain

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T6288	5552-5567	Anaphor	denotes	these molecules
T6287	5357-5362	Antecedent	denotes	HSP27
T6286	5350-5355	Antecedent	denotes	HSP32
T6285	5343-5348	Antecedent	denotes	HSP70
T6284	5457-5462	Anaphor	denotes	which
T6283	3251-3259	Antecedent	denotes	elevated
T6282	3277-3290	Anaphor	denotes	These changes
R4668	T6282	T6283	boundBy	These changes,elevated
R4669	T6284	T6285	boundBy	which,HSP70
R4670	T6284	T6286	boundBy	which,HSP32
R4671	T6284	T6287	boundBy	which,HSP27
R4672	T6288	T6285	boundBy	these molecules,HSP70
R4673	T6288	T6286	boundBy	these molecules,HSP32
R4674	T6288	T6287	boundBy	these molecules,HSP27

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T6312	6111-6115	Protein	denotes	TLR4
T6311	6010-6014	Protein	denotes	TLR4
T6310	5819-5823	Protein	denotes	TLR4
T6309	5690-5694	Protein	denotes	TLR4
T6308	5667-5671	Protein	denotes	TLR4
T6307	5357-5362	Protein	denotes	HSP27
T6306	5350-5355	Protein	denotes	HSP32
T6305	5343-5348	Protein	denotes	HSP70
T6304	5016-5020	Protein	denotes	TLR4
T6303	4983-4987	Protein	denotes	TLR4
T6302	4863-4867	Protein	denotes	TLR4
T6301	4802-4806	Protein	denotes	TLR4
T6300	4365-4369	Protein	denotes	IκBα
T6299	4349-4353	Protein	denotes	TLR4
T6298	4302-4306	Protein	denotes	TLR4
T6297	4142-4146	Protein	denotes	TLR4
T6296	3894-3898	Protein	denotes	TLR4
T6295	3622-3626	Protein	denotes	TLR4
T6294	3397-3401	Protein	denotes	TLR4
T6293	3214-3218	Protein	denotes	TLR4
T6292	3180-3184	Protein	denotes	TLR4
T6291	3119-3123	Protein	denotes	TLR4
T6290	2993-2997	Protein	denotes	TLR4
T6289	2498-2502	Protein	denotes	TLR4

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T8669	5357-5362	http://www.uniprot.org/uniprot/P04792	denotes	HSP27
T8668	4365-4369	http://www.uniprot.org/uniprot/P25963	denotes	IκBα
T8667	6111-6115	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8666	6010-6014	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8665	5819-5823	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8664	5690-5694	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8663	5667-5671	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8662	5016-5020	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8661	4983-4987	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8660	4863-4867	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8659	4802-4806	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8658	4349-4353	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8657	4302-4306	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8656	4142-4146	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8655	3894-3898	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8654	3622-3626	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8653	3397-3401	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8652	3214-3218	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8651	3180-3184	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8650	3119-3123	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8649	2993-2997	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T8648	2498-2502	http://www.uniprot.org/uniprot/O00206	denotes	TLR4

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T6192	3551-3563	http://purl.obolibrary.org/obo/UBERON_0002316	denotes	white matter
T6191	3517-3523	http://purl.obolibrary.org/obo/UBERON_0001851	denotes	cortex
T6190	2584-2591	http://purl.obolibrary.org/obo/UBERON_0012131	denotes	central
T6189	5607-5612	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T6188	5508-5513	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T6187	2859-2864	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T6186	720-725	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T6185	512-517	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T6184	6048-6054	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6183	4668-4674	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6182	3703-3709	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6181	3269-3275	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6180	1263-1269	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6179	552-558	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6178	437-443	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T6177	6249-6254	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6176	6042-6047	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6175	5839-5844	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6174	5767-5772	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6173	5588-5593	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6172	5440-5445	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6171	4662-4667	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6170	4072-4077	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6169	3697-3702	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6168	3263-3268	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6167	2179-2184	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6166	1543-1548	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6165	1257-1262	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6164	934-939	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6163	795-800	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6162	745-750	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6161	546-551	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T6160	431-436	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T6392	4997-5020	http://purl.obolibrary.org/obo/GO_0034143	denotes	signaling pathway. TLR4
T6391	4997-5020	http://purl.obolibrary.org/obo/GO_0034142	denotes	signaling pathway. TLR4
T6390	4582-4604	http://purl.obolibrary.org/obo/GO_0007252	denotes	phosphorylation of IκB
T6389	4502-4525	http://purl.obolibrary.org/obo/GO_0045824	denotes	innate immune responses
T6388	4502-4525	http://purl.obolibrary.org/obo/GO_0045089	denotes	innate immune responses
T6387	4502-4525	http://purl.obolibrary.org/obo/GO_0002218	denotes	innate immune responses
T6386	4502-4525	http://purl.obolibrary.org/obo/GO_0045088	denotes	innate immune responses
T6385	4502-4525	http://purl.obolibrary.org/obo/GO_0002227	denotes	innate immune responses
T6384	4502-4525	http://purl.obolibrary.org/obo/GO_0045087	denotes	innate immune responses
T6383	5153-5164	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6382	4390-4401	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6381	4582-4597	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6380	4370-4385	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6379	4988-5014	http://purl.obolibrary.org/obo/GO_0071847	denotes	mediated signaling pathway
T6378	4307-4333	http://purl.obolibrary.org/obo/GO_0071847	denotes	mediated signaling pathway
T6377	4988-5014	http://purl.obolibrary.org/obo/GO_0070098	denotes	mediated signaling pathway
T6376	4307-4333	http://purl.obolibrary.org/obo/GO_0070098	denotes	mediated signaling pathway
T6375	4988-5014	http://purl.obolibrary.org/obo/GO_0035689	denotes	mediated signaling pathway
T6374	4307-4333	http://purl.obolibrary.org/obo/GO_0035689	denotes	mediated signaling pathway
T6373	4988-5014	http://purl.obolibrary.org/obo/GO_0038166	denotes	mediated signaling pathway
T6372	4307-4333	http://purl.obolibrary.org/obo/GO_0038166	denotes	mediated signaling pathway
T6371	4988-5014	http://purl.obolibrary.org/obo/GO_0038161	denotes	mediated signaling pathway
T6370	4307-4333	http://purl.obolibrary.org/obo/GO_0038161	denotes	mediated signaling pathway
T6369	4988-5014	http://purl.obolibrary.org/obo/GO_0038007	denotes	mediated signaling pathway
T6368	4307-4333	http://purl.obolibrary.org/obo/GO_0038007	denotes	mediated signaling pathway
T6367	4988-5014	http://purl.obolibrary.org/obo/GO_0009755	denotes	mediated signaling pathway
T6366	4307-4333	http://purl.obolibrary.org/obo/GO_0009755	denotes	mediated signaling pathway
T6365	4988-5014	http://purl.obolibrary.org/obo/GO_0019221	denotes	mediated signaling pathway
T6364	4307-4333	http://purl.obolibrary.org/obo/GO_0019221	denotes	mediated signaling pathway
T6363	4988-5014	http://purl.obolibrary.org/obo/GO_0007229	denotes	mediated signaling pathway
T6362	4307-4333	http://purl.obolibrary.org/obo/GO_0007229	denotes	mediated signaling pathway
T6361	3913-3944	http://purl.obolibrary.org/obo/GO_1903307	denotes	pathway activates and regulates
T6360	3828-3834	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T6359	3818-3834	http://purl.obolibrary.org/obo/GO_0080117	denotes	secondary growth
T6358	2314-2326	http://purl.obolibrary.org/obo/GO_0009293	denotes	transduction
T6357	4997-5014	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathway
T6356	4873-4890	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathway
T6355	4316-4333	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathway
T6354	2429-2447	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathways
T6353	2307-2326	http://purl.obolibrary.org/obo/GO_0007165	denotes	signal transduction
T6352	6130-6139	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6351	6029-6038	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6350	5709-5718	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6349	4997-5006	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6348	4873-4882	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6347	4316-4325	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6346	4161-4170	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6345	3012-3021	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6344	2429-2438	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6343	2307-2313	http://purl.obolibrary.org/obo/GO_0023052	denotes	signal
T6342	2064-2074	http://purl.obolibrary.org/obo/GO_0007610	denotes	behavioral
T6341	3858-3863	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T6340	1920-1925	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T6339	3853-3863	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T6338	1915-1925	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T6337	4509-4525	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune responses
T6336	1444-1460	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune responses
T6335	4463-4476	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6334	4263-4276	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6333	3163-3176	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6332	1405-1418	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6331	1367-1380	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T6330	1292-1305	http://purl.obolibrary.org/obo/GO_0006351	denotes	Transcription
T6329	1200-1235	http://purl.obolibrary.org/obo/GO_0050729	denotes	inflammatory responses is activated
T6328	1200-1235	http://purl.obolibrary.org/obo/GO_0002675	denotes	inflammatory responses is activated
T6327	1200-1235	http://purl.obolibrary.org/obo/GO_0002678	denotes	inflammatory responses is activated
T6326	6160-6172	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T6325	1162-1174	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T6324	5315-5327	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T6323	4530-4542	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T6322	2050-2062	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T6321	1527-1539	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T6320	1465-1477	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T6319	4042-4064	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T6318	3963-3985	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T6317	3768-3790	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T6316	3667-3689	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T6315	1840-1862	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T6314	1200-1222	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses
T6313	875-897	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory responses

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T6398	5807-5814	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T6397	5672-5679	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T6396	1105-1120	http://purl.obolibrary.org/obo/GO_0003823	denotes	immunoglobulins

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T6405	5227-5240	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T6404	5613-5618	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6403	5514-5519	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6402	5499-5504	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6401	5264-5269	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6400	2865-2870	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6399	801-806	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T6231	5922-6262	Sentence	denotes	In conclusion, the present study demonstrated the temporal profile of the activation of TLR4-mediated NFκB signaling in brain tissue in a rat model of experimental ICH, which suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may be a therapeutic target for the prevention of ICH-induced brain damage.
T6230	5774-5921	Sentence	denotes	However, the specific endogenous ligands for TLR4 in hemorrhagic brain have not been determined and need to be identified through further research.
T6229	5526-5773	Sentence	denotes	It may be speculated that these molecules produced in damaged brain or came from blood cells and constituents of plasma server as endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling, and initiate the inflammatory responses in IHC brain.
T6228	5329-5525	Sentence	denotes	For instance, HSP70, HSP32, HSP27, and enzymes involved in oxidative stress are found to be upregulated in the brain after ICH, which may be produced by injured neuronal cells or blood cells [21].
T6227	5016-5328	Sentence	denotes	TLR4 plays an important role in the recognition of microbial components [19, 20] and can also recognize endogenous molecules such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation.
T6226	4808-5015	Sentence	denotes	Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway, which is consistent with previous reports that activation of NFκB is regulated through the TLR4-mediated signaling pathway.
T6225	4686-4807	Sentence	denotes	The temporal profile of the expression of p-IκB and the activation of NFκB was similar to that of the expression of TLR4.
T6224	4551-4685	Sentence	denotes	We observed that the levels of phosphorylation of IκB and the activity of NFκB were significantly increased in brain tissue after ICH.
T6223	4335-4550	Sentence	denotes	Activation of TLR4 stimulates IκBα phosphorylation and degradation, resulting in nuclear translocation of NFκB, which initiates transcription of genes associated with innate immune responses and inflammation [5, 6].
T6222	4242-4334	Sentence	denotes	NFκB is an important transcription factor downstream in the TLR4-mediated signaling pathway.
T6221	3987-4241	Sentence	denotes	To investigate the mechanisms underlying the increased inflammatory responses in the brain after ICH, in the present study, we evaluated the activation of TLR4-mediated NFκB signaling by detecting the p-IκB and the activity of NFκB in hemorrhagic brains.
T6220	3870-3986	Sentence	denotes	It is now believed that TLR4-mediated-NFκB pathway activates and regulates immunological and inflammatory responses.
T6219	3721-3869	Sentence	denotes	Recent studies demonstrated that ICH initiates inflammatory responses, which are associated with secondary growth of hemorrhage and cell death [18].
T6218	3572-3720	Sentence	denotes	These data indicated that increased expression of TLR4 may be related to the triggering of the inflammatory responses in the brain tissue after ICH.
T6217	3393-3571	Sentence	denotes	The TLR4 protein, detected by immunohistochemistry, was consistently distributed in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts.
T6216	3277-3392	Sentence	denotes	These changes started as early as 6 hours after the ICH insult and maintained at a high level for 7 days afterward.
T6215	3142-3276	Sentence	denotes	Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH significantly elevated in brain tissue.
T6214	3031-3141	Sentence	denotes	In the present study, we established the rat model of experimental ICH and detected the TLR4 mRNA and protein.
T6213	2708-3030	Sentence	denotes	Although previous reports indicated that the activation of NFκB was attributed to the oxidative stress or glutamate receptor activation induced by red blood cells and/or plasma constituents [17], very few studies have been directed to investigate the role and the relationship between TLR4-mediated NFκB signaling and ICH.
T6212	2498-2707	Sentence	denotes	TLR4, the first mammalian TLR recognized, has been reported to be involved in several central nervous (CNS) system diseases, such as inflammatory or autoimmune CNS diseases and cerebral ischemic injury [7, 8].
T6211	2416-2497	Sentence	denotes	TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13].
T6210	2264-2415	Sentence	denotes	Toll-like receptors (TLRs) are a family of signal transduction molecules and play a critical role in the induction of innate and adaptive immunity [4].
T6209	2130-2263	Sentence	denotes	The knowledge about how NFκB is activated in the brain subjected to ICH is critical for seeking a new neuroprotective method for ICH.
T6208	1942-2129	Sentence	denotes	Inhibition of NFκB activity has been shown to have a therapeutic effect on experimental ICH, such as reduce inflammation, behavioral dysfunction, and neuronal damage produced by ICH [17].
T6207	1811-1941	Sentence	denotes	Activation of NFκB initiates inflammatory responses and contributes to the pathobiology of perilesional cell death after ICH [16].
T6206	1649-1810	Sentence	denotes	NFκB activation occurs within minutes and persists for at least a week in response to ICH, which is associated with the expression of selected target genes [15].
T6205	1562-1648	Sentence	denotes	It has been reported that NFκB increased in the region of perihematoma after ICH [14].
T6204	1292-1561	Sentence	denotes	Transcription factor nuclear factor-kappa-B (NFκB) is an important nuclear transcription factor, which initiates transcription of genes associated with immune responses and inflammation [12, 13] and also plays a key role in regulating inflammation in brain pathologies.
T6203	1183-1291	Sentence	denotes	However, how the inflammatory responses is activated and regulated in the brain tissue after ICH is unclear.
T6202	1001-1182	Sentence	denotes	Various constituents of the inflammatory response, including adhesion molecules, cytokines, leukocytes, immunoglobulins, and complement, may be important in the pathogenesis of ICH.
T6201	871-1000	Sentence	denotes	The inflammatory responses are responsible for the ICH induced brain injury, which could provide new therapeutic targets for ICH.
T6200	677-870	Sentence	denotes	After ICH, inflammatory mediators from the blood might enter to the brain and induce an inflammatory reaction and the brain cells itself are also capable of producing many of these agents [11].
T6199	567-676	Sentence	denotes	In addition, there is increasing evidence that inflammatory processes are involved in cerebrovascular events.
T6198	473-566	Sentence	denotes	Mass effect, ischemia, and toxicity of blood components after ICH induce brain tissue damage.
T6197	353-472	Sentence	denotes	Unfortunately, the method for treatment of this disease and protection of the brain tissue after ICH are not effective.
T6196	301-352	Sentence	denotes	Only 38% of the patients survive the 1st year [10].
T6195	250-300	Sentence	denotes	Only 31% are functionally independent at 3 months.
T6194	189-249	Sentence	denotes	The mortality of ICH is higher than that of ischemic stroke.
T6193	14-188	Sentence	denotes	Intra-cerebral hemorrhage (ICH) represents 10–15% of all strokes, and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke [1].
T125	0-2	Sentence	denotes	4.
T126	3-13	Sentence	denotes	Discussion
T127	14-188	Sentence	denotes	Intra-cerebral hemorrhage (ICH) represents 10–15% of all strokes, and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke [1].
T128	189-249	Sentence	denotes	The mortality of ICH is higher than that of ischemic stroke.
T129	250-300	Sentence	denotes	Only 31% are functionally independent at 3 months.
T130	301-352	Sentence	denotes	Only 38% of the patients survive the 1st year [10].
T131	353-472	Sentence	denotes	Unfortunately, the method for treatment of this disease and protection of the brain tissue after ICH are not effective.
T132	473-566	Sentence	denotes	Mass effect, ischemia, and toxicity of blood components after ICH induce brain tissue damage.
T133	567-676	Sentence	denotes	In addition, there is increasing evidence that inflammatory processes are involved in cerebrovascular events.
T134	677-870	Sentence	denotes	After ICH, inflammatory mediators from the blood might enter to the brain and induce an inflammatory reaction and the brain cells itself are also capable of producing many of these agents [11].
T135	871-1000	Sentence	denotes	The inflammatory responses are responsible for the ICH induced brain injury, which could provide new therapeutic targets for ICH.
T136	1001-1182	Sentence	denotes	Various constituents of the inflammatory response, including adhesion molecules, cytokines, leukocytes, immunoglobulins, and complement, may be important in the pathogenesis of ICH.
T137	1183-1291	Sentence	denotes	However, how the inflammatory responses is activated and regulated in the brain tissue after ICH is unclear.
T138	1292-1561	Sentence	denotes	Transcription factor nuclear factor-kappa-B (NFκB) is an important nuclear transcription factor, which initiates transcription of genes associated with immune responses and inflammation [12, 13] and also plays a key role in regulating inflammation in brain pathologies.
T139	1562-1648	Sentence	denotes	It has been reported that NFκB increased in the region of perihematoma after ICH [14].
T140	1649-1810	Sentence	denotes	NFκB activation occurs within minutes and persists for at least a week in response to ICH, which is associated with the expression of selected target genes [15].
T141	1811-1941	Sentence	denotes	Activation of NFκB initiates inflammatory responses and contributes to the pathobiology of perilesional cell death after ICH [16].
T142	1942-2129	Sentence	denotes	Inhibition of NFκB activity has been shown to have a therapeutic effect on experimental ICH, such as reduce inflammation, behavioral dysfunction, and neuronal damage produced by ICH [17].
T143	2130-2263	Sentence	denotes	The knowledge about how NFκB is activated in the brain subjected to ICH is critical for seeking a new neuroprotective method for ICH.
T144	2264-2415	Sentence	denotes	Toll-like receptors (TLRs) are a family of signal transduction molecules and play a critical role in the induction of innate and adaptive immunity [4].
T145	2416-2497	Sentence	denotes	TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13].
T146	2498-2707	Sentence	denotes	TLR4, the first mammalian TLR recognized, has been reported to be involved in several central nervous (CNS) system diseases, such as inflammatory or autoimmune CNS diseases and cerebral ischemic injury [7, 8].
T147	2708-3030	Sentence	denotes	Although previous reports indicated that the activation of NFκB was attributed to the oxidative stress or glutamate receptor activation induced by red blood cells and/or plasma constituents [17], very few studies have been directed to investigate the role and the relationship between TLR4-mediated NFκB signaling and ICH.
T148	3031-3141	Sentence	denotes	In the present study, we established the rat model of experimental ICH and detected the TLR4 mRNA and protein.
T149	3142-3276	Sentence	denotes	Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH significantly elevated in brain tissue.
T150	3277-3392	Sentence	denotes	These changes started as early as 6 hours after the ICH insult and maintained at a high level for 7 days afterward.
T151	3393-3571	Sentence	denotes	The TLR4 protein, detected by immunohistochemistry, was consistently distributed in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts.
T152	3572-3720	Sentence	denotes	These data indicated that increased expression of TLR4 may be related to the triggering of the inflammatory responses in the brain tissue after ICH.
T153	3721-3869	Sentence	denotes	Recent studies demonstrated that ICH initiates inflammatory responses, which are associated with secondary growth of hemorrhage and cell death [18].
T154	3870-3986	Sentence	denotes	It is now believed that TLR4-mediated-NFκB pathway activates and regulates immunological and inflammatory responses.
T155	3987-4241	Sentence	denotes	To investigate the mechanisms underlying the increased inflammatory responses in the brain after ICH, in the present study, we evaluated the activation of TLR4-mediated NFκB signaling by detecting the p-IκB and the activity of NFκB in hemorrhagic brains.
T156	4242-4334	Sentence	denotes	NFκB is an important transcription factor downstream in the TLR4-mediated signaling pathway.
T157	4335-4550	Sentence	denotes	Activation of TLR4 stimulates IκBα phosphorylation and degradation, resulting in nuclear translocation of NFκB, which initiates transcription of genes associated with innate immune responses and inflammation [5, 6].
T158	4551-4685	Sentence	denotes	We observed that the levels of phosphorylation of IκB and the activity of NFκB were significantly increased in brain tissue after ICH.
T159	4686-4807	Sentence	denotes	The temporal profile of the expression of p-IκB and the activation of NFκB was similar to that of the expression of TLR4.
T160	4808-5015	Sentence	denotes	Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway, which is consistent with previous reports that activation of NFκB is regulated through the TLR4-mediated signaling pathway.
T161	5016-5328	Sentence	denotes	TLR4 plays an important role in the recognition of microbial components [19, 20] and can also recognize endogenous molecules such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation.
T162	5329-5525	Sentence	denotes	For instance, HSP70, HSP32, HSP27, and enzymes involved in oxidative stress are found to be upregulated in the brain after ICH, which may be produced by injured neuronal cells or blood cells [21].
T163	5526-5773	Sentence	denotes	It may be speculated that these molecules produced in damaged brain or came from blood cells and constituents of plasma server as endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling, and initiate the inflammatory responses in IHC brain.
T164	5774-5921	Sentence	denotes	However, the specific endogenous ligands for TLR4 in hemorrhagic brain have not been determined and need to be identified through further research.
T165	5922-6262	Sentence	denotes	In conclusion, the present study demonstrated the temporal profile of the activation of TLR4-mediated NFκB signaling in brain tissue in a rat model of experimental ICH, which suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may be a therapeutic target for the prevention of ICH-induced brain damage.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T6395	2592-2599	http://purl.bioontology.org/ontology/ICD10/R45.0	denotes	nervous
T6394	2693-2699	http://purl.bioontology.org/ontology/ICD10/T14.9	denotes	injury
T6393	940-946	http://purl.bioontology.org/ontology/ICD10/T14.9	denotes	injury

simple1

Id	Subject	Object	Predicate	Lexical cue
T6523	2498-2502	Protein	denotes	TLR4
T6546	6111-6115	Protein	denotes	TLR4
T6545	6010-6014	Protein	denotes	TLR4
T6544	5819-5823	Protein	denotes	TLR4
T6543	5690-5694	Protein	denotes	TLR4
T6542	5667-5671	Protein	denotes	TLR4
T6541	5357-5362	Protein	denotes	HSP27
T6540	5350-5355	Protein	denotes	HSP32
T6539	5343-5348	Protein	denotes	HSP70
T6538	5016-5020	Protein	denotes	TLR4
T6537	4983-4987	Protein	denotes	TLR4
T6536	4863-4867	Protein	denotes	TLR4
T6535	4802-4806	Protein	denotes	TLR4
T6534	4365-4369	Protein	denotes	IκBα
T6533	4349-4353	Protein	denotes	TLR4
T6532	4302-4306	Protein	denotes	TLR4
T6531	4142-4146	Protein	denotes	TLR4
T6530	3894-3898	Protein	denotes	TLR4
T6529	3622-3626	Protein	denotes	TLR4
T6528	3397-3401	Protein	denotes	TLR4
T6527	3214-3218	Protein	denotes	TLR4
T6526	3180-3184	Protein	denotes	TLR4
T6525	3119-3123	Protein	denotes	TLR4
T6524	2993-2997	Protein	denotes	TLR4

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T8932	3608-3618	Gene_expression	denotes	expression
T8931	3598-3607	Positive_regulation	denotes	increased
T8930	3462-3473	Localization	denotes	distributed
T8929	3411-3419	Gene_expression	denotes	detected
T8928	3163-3176	Transcription	denotes	transcription
T8927	3200-3210	Gene_expression	denotes	expression
T8926	3251-3259	Positive_regulation	denotes	elevated
T8925	3106-3114	Transcription	denotes	detected
T8924	2528-2538	Binding	denotes	recognized
T8923	6111-6115	Protein	denotes	TLR4
T8922	6010-6014	Protein	denotes	TLR4
T8921	5819-5823	Protein	denotes	TLR4
T8920	5690-5694	Protein	denotes	TLR4
T8919	5667-5671	Protein	denotes	TLR4
T8918	5357-5362	Protein	denotes	HSP27
T8917	5350-5355	Protein	denotes	HSP32
T8916	5343-5348	Protein	denotes	HSP70
T8915	5016-5020	Protein	denotes	TLR4
T8914	4983-4987	Protein	denotes	TLR4
T8913	4863-4867	Protein	denotes	TLR4
T8912	4802-4806	Protein	denotes	TLR4
T8911	4365-4369	Protein	denotes	IκBα
T8910	4349-4353	Protein	denotes	TLR4
T8909	4302-4306	Protein	denotes	TLR4
T8908	4142-4146	Protein	denotes	TLR4
T8907	3894-3898	Protein	denotes	TLR4
T8906	3622-3626	Protein	denotes	TLR4
T8905	3397-3401	Protein	denotes	TLR4
T8904	3214-3218	Protein	denotes	TLR4
T8903	3180-3184	Protein	denotes	TLR4
T8902	3119-3123	Protein	denotes	TLR4
T8901	2993-2997	Protein	denotes	TLR4
T8900	2498-2502	Protein	denotes	TLR4
T8939	5421-5432	Positive_regulation	denotes	upregulated
T8938	5110-5119	Binding	denotes	recognize
T8937	4788-4798	Gene_expression	denotes	expression
T8936	4390-4401	Protein_catabolism	denotes	degradation
T8935	4370-4385	Phosphorylation	denotes	phosphorylation
T8934	4354-4364	Positive_regulation	denotes	stimulates
T8933	4335-4345	Positive_regulation	denotes	Activation
R6944	T8900	T8924	themeOf	TLR4,recognized
R6947	T8902	T8925	themeOf	TLR4,detected
R6948	T8903	T8928	themeOf	TLR4,transcription
R6949	T8904	T8927	themeOf	TLR4,expression
R6950	T8905	T8930	themeOf	TLR4,distributed
R6951	T8905	T8929	themeOf	TLR4,detected
R6952	T8906	T8932	themeOf	TLR4,expression
R6965	T8927	T8926	themeOf	expression,elevated
R6973	T8928	T8926	themeOf	transcription,elevated
R6974	T8932	T8931	themeOf	expression,increased
R6953	T8935	T8934	themeOf	phosphorylation,stimulates
R6954	T8910	T8933	themeOf	TLR4,Activation
R6955	T8936	T8934	themeOf	degradation,stimulates
R6956	T8911	T8935	themeOf	IκBα,phosphorylation
R6957	T8911	T8936	themeOf	IκBα,degradation
R6958	T8912	T8937	themeOf	TLR4,expression
R6959	T8915	T8938	themeOf	TLR4,recognize
R6960	T8916	T8939	themeOf	HSP70,upregulated
R6962	T8917	T8939	themeOf	HSP32,upregulated
R6964	T8918	T8939	themeOf	HSP27,upregulated

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T8707	5672-5679	Binding	denotes	ligands
T8706	5421-5432	Positive_regulation	denotes	upregulated
T8705	4834-4844	Positive_regulation	denotes	stimulates
T8704	4845-4855	Positive_regulation	denotes	activation
T8703	4788-4798	Gene_expression	denotes	expression
T8702	4390-4401	Protein_catabolism	denotes	degradation
T8701	4370-4385	Phosphorylation	denotes	phosphorylation
T8700	4354-4364	Positive_regulation	denotes	stimulates
T8699	4335-4345	Positive_regulation	denotes	Activation
T8698	3608-3618	Gene_expression	denotes	expression
T8697	3598-3607	Positive_regulation	denotes	increased
T8696	3163-3176	Transcription	denotes	transcription
T8695	3251-3259	Positive_regulation	denotes	elevated
T8694	3200-3210	Gene_expression	denotes	expression
T8693	6111-6115	Protein	denotes	TLR4
T8692	6010-6014	Protein	denotes	TLR4
T8691	5819-5823	Protein	denotes	TLR4
T8690	5690-5694	Protein	denotes	TLR4
T8689	5667-5671	Protein	denotes	TLR4
T8688	5357-5362	Protein	denotes	HSP27
T8687	5350-5355	Protein	denotes	HSP32
T8686	5343-5348	Protein	denotes	HSP70
T8685	5016-5020	Protein	denotes	TLR4
T8684	4983-4987	Protein	denotes	TLR4
T8683	4863-4867	Protein	denotes	TLR4
T8682	4802-4806	Protein	denotes	TLR4
T8681	4365-4369	Protein	denotes	IκBα
T8680	4349-4353	Protein	denotes	TLR4
T8679	4302-4306	Protein	denotes	TLR4
T8678	4142-4146	Protein	denotes	TLR4
T8677	3894-3898	Protein	denotes	TLR4
T8676	3622-3626	Protein	denotes	TLR4
T8675	3397-3401	Protein	denotes	TLR4
T8674	3214-3218	Protein	denotes	TLR4
T8673	3180-3184	Protein	denotes	TLR4
T8672	3119-3123	Protein	denotes	TLR4
T8671	2993-2997	Protein	denotes	TLR4
T8670	2498-2502	Protein	denotes	TLR4
R6846	T8673	T8694	themeOf	TLR4,expression
R6847	T8673	T8696	themeOf	TLR4,transcription
R6849	T8674	T8694	themeOf	TLR4,expression
R6851	T8676	T8698	themeOf	TLR4,expression
R6853	T8680	T8699	themeOf	TLR4,Activation
R6854	T8681	T8701	themeOf	IκBα,phosphorylation
R6855	T8681	T8702	themeOf	IκBα,degradation
R6856	T8682	T8703	themeOf	TLR4,expression
R6857	T8683	T8704	themeOf	TLR4,activation
R6858	T8686	T8706	themeOf	HSP70,upregulated
R6859	T8687	T8706	themeOf	HSP32,upregulated
R6861	T8688	T8706	themeOf	HSP27,upregulated
R6862	T8689	T8707	themeOf	TLR4,ligands
R6864	T8694	T8695	themeOf	expression,elevated
R6865	T8694	T8695	themeOf	expression,elevated
R6867	T8696	T8695	themeOf	transcription,elevated
R6868	T8698	T8697	themeOf	expression,increased
R6870	T8699	T8700	causeOf	Activation,stimulates
R6871	T8699	T8700	causeOf	Activation,stimulates
R6872	T8701	T8700	themeOf	phosphorylation,stimulates
R6873	T8702	T8700	themeOf	degradation,stimulates
R6875	T8704	T8705	themeOf	activation,stimulates

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T8726	5357-5362	Protein	denotes	HSP27
T8725	5350-5355	Protein	denotes	HSP32
T8724	5343-5348	Protein	denotes	HSP70
T8723	5016-5020	Protein	denotes	TLR4
T8722	4983-4987	Protein	denotes	TLR4
T8721	4863-4867	Protein	denotes	TLR4
T8720	4802-4806	Protein	denotes	TLR4
T8719	4365-4369	Protein	denotes	IκBα
T8718	4349-4353	Protein	denotes	TLR4
T8717	4302-4306	Protein	denotes	TLR4
T8716	4142-4146	Protein	denotes	TLR4
T8715	3894-3898	Protein	denotes	TLR4
T8714	3622-3626	Protein	denotes	TLR4
T8713	3397-3401	Protein	denotes	TLR4
T8712	3214-3218	Protein	denotes	TLR4
T8711	3180-3184	Protein	denotes	TLR4
T8710	3119-3123	Protein	denotes	TLR4
T8709	2993-2997	Protein	denotes	TLR4
T8708	2498-2502	Protein	denotes	TLR4
T8729	5819-5823	Protein	denotes	TLR4
T8728	5690-5694	Protein	denotes	TLR4
T8727	5667-5671	Protein	denotes	TLR4
T8747	6116-6124	Positive_regulation	denotes	mediated
T8746	5421-5432	Positive_regulation	denotes	upregulated
T8745	4834-4844	Positive_regulation	denotes	stimulates
T8744	4845-4855	Positive_regulation	denotes	activation
T8743	4788-4798	Gene_expression	denotes	expression
T8742	4354-4364	Positive_regulation	denotes	stimulates
T8741	4390-4401	Protein_catabolism	denotes	degradation
T8740	4370-4385	Phosphorylation	denotes	phosphorylation
T8739	4335-4345	Positive_regulation	denotes	Activation
T8738	4147-4155	Positive_regulation	denotes	mediated
T8737	3598-3607	Positive_regulation	denotes	increased
T8736	3634-3641	Positive_regulation	denotes	related
T8735	3608-3618	Gene_expression	denotes	expression
T8734	3251-3259	Positive_regulation	denotes	elevated
T8733	3200-3210	Gene_expression	denotes	expression
T8732	3163-3176	Transcription	denotes	transcription
T8731	6111-6115	Protein	denotes	TLR4
T8730	6010-6014	Protein	denotes	TLR4
R6852	T8711	T8732	themeOf	TLR4,transcription
R6860	T8712	T8733	themeOf	TLR4,expression
R6863	T8714	T8735	themeOf	TLR4,expression
R6866	T8716	T8738	themeOf	TLR4,mediated
R6869	T8718	T8739	themeOf	TLR4,Activation
R6874	T8719	T8740	themeOf	IκBα,phosphorylation
R6876	T8719	T8741	themeOf	IκBα,degradation
R6885	T8733	T8734	themeOf	expression,elevated
R6887	T8735	T8736	themeOf	expression,related
R6888	T8735	T8737	themeOf	expression,increased
R6892	T8740	T8742	themeOf	phosphorylation,stimulates
R6877	T8720	T8743	themeOf	TLR4,expression
R6878	T8721	T8744	themeOf	TLR4,activation
R6879	T8724	T8746	themeOf	HSP70,upregulated
R6880	T8725	T8746	themeOf	HSP32,upregulated
R6881	T8726	T8746	themeOf	HSP27,upregulated
R6883	T8731	T8747	themeOf	TLR4,mediated
R6890	T8739	T8742	causeOf	Activation,stimulates
R6891	T8739	T8742	causeOf	Activation,stimulates
R6893	T8741	T8742	themeOf	degradation,stimulates
R6894	T8744	T8745	themeOf	activation,stimulates

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T9012	4242-4246	Protein	denotes	NFκB
T9011	4211-4218	Protein	denotes	of NFκB
T9010	3133-3140	Protein	denotes	protein
T9009	5552-5593	Entity	denotes	these molecules produced in damaged brain
T9008	1419-1427	Protein	denotes	of genes
T9007	1082-1091	Protein	denotes	cytokines
T9006	3177-3184	Protein	denotes	of TLR4
T9005	1811-1829	Protein	denotes	Activation of NFκB
T9004	5656-5719	Entity	denotes	endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling,
T9003	1337-1341	Protein	denotes	NFκB
T8956	2480-2487	Protein	denotes	of NFκB
T8955	5284-5292	Protein	denotes	of genes
T8954	6125-6129	Protein	denotes	NFκB
T8953	4365-4369	Protein	denotes	IκBα
T8952	6024-6028	Protein	denotes	NFκB
T8951	1780-1809	Protein	denotes	of selected target genes [15]
T8950	3619-3626	Protein	denotes	of TLR4
T8949	3007-3011	Protein	denotes	NFκB
T8948	5508-5524	Entity	denotes	blood cells [21]
T8947	1956-1960	Protein	denotes	NFκB
T8946	5174-5191	Entity	denotes	of macromolecules
T8945	138-154	Entity	denotes	the thrombolytic
T8944	4438-4445	Protein	denotes	of NFκB
T8943	4142-4155	Protein	denotes	TLR4-mediated
T8942	1093-1103	Entity	denotes	leukocytes
T8941	4346-4353	Protein	denotes	of TLR4
T8940	3393-3409	Protein	denotes	The TLR4 protein
T8899	6111-6139	Positive_regulation	denotes	TLR4-mediated NFκB signaling
T8898	4463-4542	Transcription	denotes	transcription of genes associated with innate immune responses and inflammation
T8897	2416-2496	Positive_regulation	denotes	TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13]
T8887	5819-5845	Localization	denotes	TLR4 in hemorrhagic brain
T8886	5690-5718	Positive_regulation	denotes	TLR4-mediated NFκB signaling
T8885	3598-3626	Gene_expression	denotes	increased expression of TLR4
T8884	3598-3626	Positive_regulation	denotes	increased expression of TLR4
T8883	2985-3021	Positive_regulation	denotes	between TLR4-mediated NFκB signaling
T8882	1942-1969	Negative_regulation	denotes	Inhibition of NFκB activity
T8881	1749-1809	Gene_expression	denotes	associated with the expression of selected target genes [15]
T8880	3196-3236	Gene_expression	denotes	the expression of TLR4 protein after ICH
T8879	4365-4385	Phosphorylation	denotes	IκBα phosphorylation
T8878	2814-2870	Positive_regulation	denotes	glutamate receptor activation induced by red blood cells
T8877	6007-6038	Positive_regulation	denotes	of TLR4-mediated NFκB signaling
T8876	4939-4957	Positive_regulation	denotes	activation of NFκB
T8875	2985-3021	Regulation	denotes	between TLR4-mediated NFκB signaling
T8874	6111-6139	Regulation	denotes	TLR4-mediated NFκB signaling
T8873	4738-4760	Positive_regulation	denotes	the activation of NFκB
T8872	4335-4353	Positive_regulation	denotes	Activation of TLR4
T8871	4139-4170	Regulation	denotes	of TLR4-mediated NFκB signaling
T8870	4808-4891	Positive_regulation	denotes	Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway,
T8888	2154-2201	Positive_regulation	denotes	NFκB is activated in the brain subjected to ICH
T8896	2749-2771	Positive_regulation	denotes	the activation of NFκB
T8895	1405-1482	Transcription	denotes	transcription of genes associated with immune responses and inflammation [12,
T8894	3142-3236	Transcription	denotes	Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH
T8893	4784-4806	Gene_expression	denotes	the expression of TLR4
T8892	5690-5718	Regulation	denotes	TLR4-mediated NFκB signaling
T8891	4139-4170	Positive_regulation	denotes	of TLR4-mediated NFκB signaling
T8890	2465-2496	Positive_regulation	denotes	the activation of NFκB [12, 13]
T8889	6007-6038	Regulation	denotes	of TLR4-mediated NFκB signaling
T9002	2993-3006	Protein	denotes	TLR4-mediated
T9001	5120-5140	Entity	denotes	endogenous molecules
T9000	5264-5270	Entity	denotes	cells,
T8999	4302-4315	Protein	denotes	TLR4-mediated
T8998	473-477	Protein	denotes	Mass
T8997	5667-5671	Protein	denotes	TLR4
T8996	3894-3920	Protein	denotes	TLR4-mediated-NFκB pathway
T8995	5357-5362	Protein	denotes	HSP27
T8994	2154-2158	Protein	denotes	NFκB
T8993	4983-4996	Protein	denotes	TLR4-mediated
T8992	5819-5844	Protein	denotes	TLR4 in hemorrhagic brain
T8991	5016-5020	Protein	denotes	TLR4
T8990	3211-3226	Protein	denotes	of TLR4 protein
T8989	5368-5404	Protein	denotes	enzymes involved in oxidative stress
T8988	5607-5618	Entity	denotes	blood cells
T8987	5783-5844	Entity	denotes	the specific endogenous ligands for TLR4 in hemorrhagic brain
T8986	3115-3128	Protein	denotes	the TLR4 mRNA
T8985	2307-2336	Entity	denotes	signal transduction molecules
T8984	2824-2832	Protein	denotes	receptor
T8983	4753-4760	Protein	denotes	of NFκB
T8982	4156-4160	Protein	denotes	NFκB
T8981	4799-4806	Protein	denotes	of TLR4
T8980	1583-1592	Protein	denotes	that NFκB
T8979	2814-2823	Entity	denotes	glutamate
T8978	4477-4485	Protein	denotes	of genes
T8977	5227-5240	Entity	denotes	intracellular
T8976	5350-5355	Protein	denotes	HSP32
T8975	4950-4957	Protein	denotes	of NFκB
T8974	4856-4891	Protein	denotes	of the TLR4/NFκB signaling pathway,
T8973	5690-5703	Protein	denotes	TLR4-mediated
T8972	5343-5355	Protein	denotes	HSP70, HSP32
T8971	3119-3123	Protein	denotes	TLR4
T8970	1062-1080	Entity	denotes	adhesion molecules
T8969	5482-5504	Entity	denotes	injured neuronal cells
T8968	6111-6124	Protein	denotes	TLR4-mediated
T8967	791-806	Entity	denotes	the brain cells
T8966	3894-3907	Protein	denotes	TLR4-mediated
T8965	1105-1120	Protein	denotes	immunoglobulins
T8964	4622-4629	Protein	denotes	of NFκB
T8963	5704-5708	Protein	denotes	NFκB
T8962	1649-1664	Protein	denotes	NFκB activation
T8961	3397-3401	Protein	denotes	TLR4
T8960	3525-3540	Entity	denotes	thalamic nuclei
T8959	3214-3218	Protein	denotes	TLR4
T8958	6010-6023	Protein	denotes	TLR4-mediated
T8957	2264-2290	Protein	denotes	Toll-like receptors (TLRs)
T9015	2764-2771	Protein	denotes	of NFκB
T9014	4868-4872	Protein	denotes	NFκB
T9013	2498-2539	Protein	denotes	TLR4, the first mammalian TLR recognized,
R6940	T8891	T8871	themeOf	of TLR4-mediated NFκB signaling,of TLR4-mediated NFκB signaling
R6941	T8899	T8874	themeOf	TLR4-mediated NFκB signaling,TLR4-mediated NFκB signaling
R6961	T8941	T8872	themeOf	of TLR4,Activation of TLR4
R6963	T8943	T8871	causeOf	TLR4-mediated,of TLR4-mediated NFκB signaling
R6978	T8968	T8874	causeOf	TLR4-mediated,TLR4-mediated NFκB signaling
R6985	T8983	T8873	themeOf	of NFκB,the activation of NFκB
R6990	T9002	T8875	causeOf	TLR4-mediated,between TLR4-mediated NFκB signaling
R6967	T8950	T8885	themeOf	of TLR4,increased expression of TLR4
R6968	T8951	T8881	themeOf	of selected target genes [15],associated with the expression of selected target genes [15]
R6969	T8952	T8877	causeOf	NFκB,of TLR4-mediated NFκB signaling
R6970	T8953	T8879	themeOf	IκBα,IκBα phosphorylation
R6971	T8954	T8899	causeOf	NFκB,TLR4-mediated NFκB signaling
R6972	T8956	T8890	themeOf	of NFκB,"the activation of NFκB [12, 13]"
R6975	T9015	T8896	themeOf	of NFκB,the activation of NFκB
R6976	T8958	T8889	causeOf	TLR4-mediated,of TLR4-mediated NFκB signaling
R6977	T8963	T8886	causeOf	NFκB,TLR4-mediated NFκB signaling
R6979	T8973	T8892	causeOf	TLR4-mediated,TLR4-mediated NFκB signaling
R6980	T8975	T8876	themeOf	of NFκB,activation of NFκB
R6981	T8978	T8898	themeOf	of genes,transcription of genes associated with innate immune responses and inflammation
R6982	T8979	T8878	causeOf	glutamate,glutamate receptor activation induced by red blood cells
R6983	T8981	T8893	themeOf	of TLR4,the expression of TLR4
R6984	T8982	T8891	causeOf	NFκB,of TLR4-mediated NFκB signaling
R6986	T8984	T8878	themeOf	receptor,glutamate receptor activation induced by red blood cells
R6987	T8990	T8880	themeOf	of TLR4 protein,the expression of TLR4 protein after ICH
R6988	T8992	T8887	themeOf	TLR4 in hemorrhagic brain,TLR4 in hemorrhagic brain
R6989	T8994	T8888	themeOf	NFκB,NFκB is activated in the brain subjected to ICH
R6991	T9006	T8894	themeOf	of TLR4,Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH
R6992	T9008	T8895	themeOf	of genes,"transcription of genes associated with immune responses and inflammation [12,"
R6935	T8890	T8897	themeOf	"the activation of NFκB [12, 13]","TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13]"
R6942	T8877	T8889	themeOf	of TLR4-mediated NFκB signaling,of TLR4-mediated NFκB signaling
R6943	T8883	T8875	themeOf	between TLR4-mediated NFκB signaling,between TLR4-mediated NFκB signaling
R6945	T8885	T8884	themeOf	increased expression of TLR4,increased expression of TLR4
R6946	T8886	T8892	themeOf	TLR4-mediated NFκB signaling,TLR4-mediated NFκB signaling
R6966	T8949	T8883	causeOf	NFκB,between TLR4-mediated NFκB signaling

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T8647	6261-6262	.	denotes	.
T8646	6255-6261	NN	denotes	damage
T8645	6249-6254	NN	denotes	brain
T8644	6237-6248	JJ	denotes	ICH-induced
T8643	6234-6236	IN	denotes	of
T8642	6223-6233	NN	denotes	prevention
T8641	6219-6222	DT	denotes	the
T8640	6215-6218	IN	denotes	for
T8639	6208-6214	NN	denotes	target
T8638	6196-6207	JJ	denotes	therapeutic
T8637	6194-6195	DT	denotes	a
T8636	6191-6193	VB	denotes	be
T8635	6187-6190	MD	denotes	may
T8634	6181-6186	WDT	denotes	which
T8633	6179-6180	,	denotes	,
T8632	6176-6179	NNP	denotes	ICH
T8631	6173-6175	IN	denotes	of
T8630	6160-6172	NN	denotes	pathogenesis
T8629	6156-6159	DT	denotes	the
T8628	6153-6155	IN	denotes	in
T8627	6140-6152	VBZ	denotes	participates
T8626	6130-6139	VBG	denotes	signaling
T8625	6125-6129	NNP	denotes	NFκB
T8624	6111-6124	JJ	denotes	TLR4-mediated
T8623	6106-6110	IN	denotes	that
T8622	6097-6105	VBZ	denotes	suggests
T8621	6091-6096	WDT	denotes	which
T8620	6089-6090	,	denotes	,
T8619	6086-6089	NNP	denotes	ICH
T8618	6073-6085	JJ	denotes	experimental
T8617	6070-6072	IN	denotes	of
T8616	6064-6069	NN	denotes	model
T8615	6060-6063	NN	denotes	rat
T8614	6058-6059	DT	denotes	a
T8613	6055-6057	IN	denotes	in
T8612	6048-6054	NN	denotes	tissue
T8611	6042-6047	NN	denotes	brain
T8610	6039-6041	IN	denotes	in
T8609	6029-6038	VBG	denotes	signaling
T8608	6024-6028	NNP	denotes	NFκB
T8607	6010-6023	JJ	denotes	TLR4-mediated
T8606	6007-6009	IN	denotes	of
T8605	5996-6006	NN	denotes	activation
T8604	5992-5995	DT	denotes	the
T8603	5989-5991	IN	denotes	of
T8602	5981-5988	NN	denotes	profile
T8601	5972-5980	JJ	denotes	temporal
T8600	5968-5971	DT	denotes	the
T8599	5955-5967	VBD	denotes	demonstrated
T8598	5949-5954	NN	denotes	study
T8597	5941-5948	JJ	denotes	present
T8596	5937-5940	DT	denotes	the
T8595	5935-5936	,	denotes	,
T8594	5925-5935	NN	denotes	conclusion
T8593	5922-5924	IN	denotes	In
T8592	5920-5921	.	denotes	.
T8591	5912-5920	NN	denotes	research
T8590	5904-5911	JJ	denotes	further
T8589	5896-5903	IN	denotes	through
T8588	5885-5895	VBN	denotes	identified
T8587	5882-5884	VB	denotes	be
T8586	5879-5881	TO	denotes	to
T8585	5874-5878	VBP	denotes	need
T8524	5514-5519	NNS	denotes	cells
T8523	5508-5513	NN	denotes	blood
T8522	5505-5507	CC	denotes	or
T8521	5499-5504	NNS	denotes	cells
T8520	5490-5498	JJ	denotes	neuronal
T8519	5482-5489	JJ	denotes	injured
T8518	5479-5481	IN	denotes	by
T8517	5470-5478	VBN	denotes	produced
T8516	5467-5469	VB	denotes	be
T8515	5463-5466	MD	denotes	may
T8514	5457-5462	WDT	denotes	which
T8513	5455-5456	,	denotes	,
T8512	5452-5455	NNP	denotes	ICH
T8511	5446-5451	IN	denotes	after
T8510	5440-5445	NN	denotes	brain
T8509	5436-5439	DT	denotes	the
T8508	5433-5435	IN	denotes	in
T8507	5421-5432	VBN	denotes	upregulated
T8506	5418-5420	VB	denotes	be
T8505	5415-5417	TO	denotes	to
T8504	5409-5414	VBN	denotes	found
T8503	5405-5408	VBP	denotes	are
T8502	5398-5404	NN	denotes	stress
T8501	5388-5397	JJ	denotes	oxidative
T8500	5385-5387	IN	denotes	in
T8499	5376-5384	VBN	denotes	involved
T8498	5368-5375	VBZ	denotes	enzymes
T8497	5364-5367	CC	denotes	and
T8496	5362-5363	,	denotes	,
T8495	5357-5362	NNP	denotes	HSP27
T8494	5355-5356	,	denotes	,
T8493	5350-5355	NNP	denotes	HSP32
T8492	5348-5349	,	denotes	,
T8491	5343-5348	NNP	denotes	HSP70
T8490	5341-5342	,	denotes	,
T8489	5333-5341	NN	denotes	instance
T8488	5329-5332	IN	denotes	For
T8487	5327-5328	.	denotes	.
T8486	5315-5327	NN	denotes	inflammation
T8485	5312-5314	IN	denotes	by
T8484	5302-5311	VBN	denotes	activated
T8483	5298-5301	VBP	denotes	are
T8482	5293-5297	WDT	denotes	that
T8481	5287-5292	NNS	denotes	genes
T8480	5284-5286	IN	denotes	of
T8479	5275-5283	NNS	denotes	products
T8478	5271-5274	CC	denotes	and
T8477	5269-5270	,	denotes	,
T8476	5264-5269	NNS	denotes	cells
T8475	5255-5263	VBN	denotes	ruptured
T8474	5252-5254	IN	denotes	of
T8473	5241-5251	NNS	denotes	components
T8472	5227-5240	JJ	denotes	intracellular
T8471	5225-5226	,	denotes	,
T8470	5217-5225	NNS	denotes	cascades
T8469	5205-5216	JJ	denotes	proteolytic
T8468	5202-5204	IN	denotes	of
T8467	5193-5201	NNS	denotes	products
T8466	5191-5192	,	denotes	,
T8465	5177-5191	NNS	denotes	macromolecules
T8464	5174-5176	IN	denotes	of
T8463	5165-5173	NNS	denotes	products
T8462	5153-5164	NN	denotes	degradation
T8461	5149-5152	DT	denotes	the
T8460	5146-5148	IN	denotes	as
T8459	5141-5145	JJ	denotes	such
T8458	5131-5140	NNS	denotes	molecules
T8457	5120-5130	JJ	denotes	endogenous
T8456	5110-5119	VB	denotes	recognize
T8455	5105-5109	RB	denotes	also
T8454	5101-5104	MD	denotes	can
T8453	5097-5100	CC	denotes	and
T8452	5095-5096	NN	denotes	]
T8451	5093-5095	CD	denotes	20
T8450	5091-5092	,	denotes	,
T8449	5089-5091	CD	denotes	19
T8448	5088-5089	NNP	denotes	[
T8447	5077-5087	NNS	denotes	components
T8446	5067-5076	JJ	denotes	microbial
T8445	5064-5066	IN	denotes	of
T8444	5052-5063	NN	denotes	recognition
T8443	5048-5051	DT	denotes	the
T8442	5045-5047	IN	denotes	in
T8441	5040-5044	NN	denotes	role
T8440	5030-5039	JJ	denotes	important
T8439	5027-5029	DT	denotes	an
T8438	5021-5026	VBZ	denotes	plays
T8437	5016-5020	CD	denotes	TLR4
T8436	5014-5015	.	denotes	.
T8435	5007-5014	NN	denotes	pathway
T8434	4997-5006	VBG	denotes	signaling
T8433	4983-4996	JJ	denotes	TLR4-mediated
T8432	4979-4982	DT	denotes	the
T8431	4971-4978	IN	denotes	through
T8430	4961-4970	VBN	denotes	regulated
T8429	4958-4960	VBZ	denotes	is
T8428	4953-4957	NNP	denotes	NFκB
T8427	4950-4952	IN	denotes	of
T8426	4939-4949	NN	denotes	activation
T8425	4934-4938	IN	denotes	that
T8424	4926-4933	NNS	denotes	reports
T8423	4917-4925	JJ	denotes	previous
T8422	4912-4916	IN	denotes	with
T8421	4901-4911	JJ	denotes	consistent
T8420	4898-4900	VBZ	denotes	is
T8419	4892-4897	WDT	denotes	which
T8418	4890-4891	,	denotes	,
T8417	4883-4890	NN	denotes	pathway
T8416	4873-4882	VBG	denotes	signaling
T8415	4870-4872	NN	denotes	κB
T8414	4863-4870	CD	denotes	TLR4/NF
T8413	4859-4862	DT	denotes	the
T8412	4856-4858	IN	denotes	of
T8411	4845-4855	NN	denotes	activation
T8410	4834-4844	VBZ	denotes	stimulates
T8409	4830-4833	NNP	denotes	ICH
T8408	4825-4829	IN	denotes	that
T8407	4817-4824	VBP	denotes	suggest
T8406	4812-4816	NNS	denotes	data
T8405	4808-4811	PRP$	denotes	Our
T8404	4806-4807	.	denotes	.
T8403	4802-4806	CD	denotes	TLR4
T8402	4799-4801	IN	denotes	of
T8401	4788-4798	NN	denotes	expression
T8400	4784-4787	DT	denotes	the
T8399	4781-4783	IN	denotes	of
T8398	4776-4780	DT	denotes	that
T8397	4773-4775	TO	denotes	to
T8396	4765-4772	JJ	denotes	similar
T8395	4761-4764	VBD	denotes	was
T8394	4756-4760	NNP	denotes	NFκB
T8393	4753-4755	IN	denotes	of
T8392	4742-4752	NN	denotes	activation
T8391	4738-4741	DT	denotes	the
T8390	4734-4737	CC	denotes	and
T8389	4728-4733	NN	denotes	p-IκB
T8388	4725-4727	IN	denotes	of
T8387	4714-4724	NN	denotes	expression
T8386	4710-4713	DT	denotes	the
T8385	4707-4709	IN	denotes	of
T8384	4699-4706	NN	denotes	profile
T8383	4690-4698	JJ	denotes	temporal
T8382	4686-4689	DT	denotes	The
T8381	4684-4685	.	denotes	.
T8380	4681-4684	NNP	denotes	ICH
T8379	4675-4680	IN	denotes	after
T8378	4668-4674	NN	denotes	tissue
T8377	4662-4667	NN	denotes	brain
T8376	4659-4661	IN	denotes	in
T8375	4649-4658	VBN	denotes	increased
T8374	4635-4648	RB	denotes	significantly
T8373	4630-4634	VBD	denotes	were
T8372	4625-4629	NNP	denotes	NFκB
T8371	4622-4624	IN	denotes	of
T8370	4613-4621	NN	denotes	activity
T8369	4609-4612	DT	denotes	the
T8368	4605-4608	CC	denotes	and
T8367	4601-4604	NNP	denotes	IκB
T8366	4598-4600	IN	denotes	of
T8365	4582-4597	NN	denotes	phosphorylation
T8364	4579-4581	IN	denotes	of
T8363	4572-4578	NNS	denotes	levels
T8362	4568-4571	DT	denotes	the
T8361	4563-4567	IN	denotes	that
T8360	4554-4562	VBD	denotes	observed
T8359	4551-4553	PRP	denotes	We
T8358	4549-4550	.	denotes	.
T8357	4548-4549	NN	denotes	]
T8356	4547-4548	CD	denotes	6
T8355	4545-4546	,	denotes	,
T8354	4544-4545	CD	denotes	5
T8353	4543-4544	NN	denotes	[
T8352	4530-4542	NN	denotes	inflammation
T8351	4526-4529	CC	denotes	and
T8350	4516-4525	NNS	denotes	responses
T8349	4509-4515	JJ	denotes	immune
T8348	4502-4508	JJ	denotes	innate
T8347	4497-4501	IN	denotes	with
T8346	4486-4496	VBN	denotes	associated
T8345	4480-4485	NNS	denotes	genes
T8344	4477-4479	IN	denotes	of
T8343	4463-4476	NN	denotes	transcription
T8342	4453-4462	VBZ	denotes	initiates
T8341	4447-4452	WDT	denotes	which
T8340	4445-4446	,	denotes	,
T8339	4441-4445	NNP	denotes	NFκB
T8338	4438-4440	IN	denotes	of
T8337	4424-4437	NN	denotes	translocation
T8336	4416-4423	JJ	denotes	nuclear
T8335	4413-4415	IN	denotes	in
T8334	4403-4412	VBG	denotes	resulting
T8333	4401-4402	,	denotes	,
T8332	4390-4401	NN	denotes	degradation
T8331	4386-4389	CC	denotes	and
T8330	4370-4385	NN	denotes	phosphorylation
T8329	4365-4369	NNP	denotes	IκBα
T8328	4354-4364	NNS	denotes	stimulates
T8327	4349-4353	CD	denotes	TLR4
T8326	4346-4348	IN	denotes	of
T8325	4335-4345	NNP	denotes	Activation
T8324	4333-4334	.	denotes	.
T8323	4326-4333	NN	denotes	pathway
T8322	4316-4325	VBG	denotes	signaling
T8321	4302-4315	JJ	denotes	TLR4-mediated
T8320	4298-4301	DT	denotes	the
T8319	4295-4297	IN	denotes	in
T8318	4284-4294	JJ	denotes	downstream
T8317	4277-4283	NN	denotes	factor
T8316	4263-4276	NN	denotes	transcription
T8315	4253-4262	JJ	denotes	important
T8314	4250-4252	DT	denotes	an
T8313	4247-4249	VBZ	denotes	is
T8312	4242-4246	NNP	denotes	NFκB
T8311	4240-4241	.	denotes	.
T8310	4234-4240	NNS	denotes	brains
T8309	4222-4233	JJ	denotes	hemorrhagic
T8210	3593-3597	IN	denotes	that
T8209	3583-3592	VBD	denotes	indicated
T8208	3578-3582	NNS	denotes	data
T8207	3572-3577	DT	denotes	These
T8206	3570-3571	.	denotes	.
T8205	3564-3570	NNS	denotes	tracts
T8204	3557-3563	NN	denotes	matter
T8203	3551-3556	JJ	denotes	white
T8202	3546-3550	DT	denotes	some
T8201	3542-3545	CC	denotes	and
T8200	3540-3541	,	denotes	,
T8199	3534-3540	NNS	denotes	nuclei
T8198	3525-3533	JJ	denotes	thalamic
T8197	3523-3524	,	denotes	,
T8196	3517-3523	NN	denotes	cortex
T8195	3515-3516	,	denotes	,
T8194	3504-3515	NN	denotes	hippocampus
T8193	3500-3503	DT	denotes	the
T8192	3498-3499	,	denotes	,
T8191	3493-3498	NNS	denotes	areas
T8190	3477-3492	JJ	denotes	peri-hemorrhage
T8189	3474-3476	IN	denotes	in
T8188	3462-3473	VBN	denotes	distributed
T8187	3449-3461	RB	denotes	consistently
T8186	3445-3448	VBD	denotes	was
T8185	3443-3444	,	denotes	,
T8184	3423-3443	NN	denotes	immunohistochemistry
T8183	3420-3422	IN	denotes	by
T8182	3411-3419	VBN	denotes	detected
T8181	3409-3410	,	denotes	,
T8180	3402-3409	NN	denotes	protein
T8179	3397-3401	CD	denotes	TLR4
T8178	3393-3396	DT	denotes	The
T8177	3391-3392	.	denotes	.
T8176	3382-3391	RB	denotes	afterward
T8175	3377-3381	NNS	denotes	days
T8174	3375-3376	CD	denotes	7
T8173	3371-3374	IN	denotes	for
T8172	3365-3370	NN	denotes	level
T8171	3360-3364	JJ	denotes	high
T8170	3358-3359	DT	denotes	a
T8169	3355-3357	IN	denotes	at
T8168	3344-3354	VBD	denotes	maintained
T8167	3340-3343	CC	denotes	and
T8166	3333-3339	NN	denotes	insult
T8165	3329-3332	NNP	denotes	ICH
T8164	3325-3328	DT	denotes	the
T8163	3319-3324	IN	denotes	after
T8162	3313-3318	NNS	denotes	hours
T8161	3311-3312	CD	denotes	6
T8160	3308-3310	IN	denotes	as
T8159	3302-3307	JJ	denotes	early
T8158	3299-3301	RB	denotes	as
T8157	3291-3298	VBD	denotes	started
T8156	3283-3290	NNS	denotes	changes
T8155	3277-3282	DT	denotes	These
T8154	3275-3276	.	denotes	.
T8153	3269-3275	NN	denotes	tissue
T8152	3263-3268	NN	denotes	brain
T8151	3260-3262	IN	denotes	in
T8150	3251-3259	VBD	denotes	elevated
T8149	3237-3250	RB	denotes	significantly
T8148	3233-3236	NNP	denotes	ICH
T8147	3227-3232	IN	denotes	after
T8146	3219-3226	NN	denotes	protein
T8145	3214-3218	CD	denotes	TLR4
T8144	3211-3213	IN	denotes	of
T8143	3200-3210	NN	denotes	expression
T8142	3196-3199	DT	denotes	the
T8141	3193-3195	IN	denotes	as
T8140	3188-3192	RB	denotes	well
T8139	3185-3187	RB	denotes	as
T8138	3180-3184	CD	denotes	TLR4
T8137	3177-3179	IN	denotes	of
T8136	3163-3176	NN	denotes	transcription
T8135	3158-3162	IN	denotes	that
T8134	3151-3157	VBD	denotes	showed
T8133	3146-3150	NNS	denotes	data
T8132	3142-3145	PRP$	denotes	Our
T8131	3140-3141	.	denotes	.
T8130	3133-3140	NN	denotes	protein
T8129	3129-3132	CC	denotes	and
T8128	3124-3128	NNP	denotes	mRNA
T8127	3119-3123	CD	denotes	TLR4
T8126	3115-3118	DT	denotes	the
T8125	3106-3114	VBD	denotes	detected
T8124	3102-3105	CC	denotes	and
T8123	3098-3101	NNP	denotes	ICH
T8122	3085-3097	JJ	denotes	experimental
T8121	3082-3084	IN	denotes	of
T8120	3076-3081	NN	denotes	model
T8119	3072-3075	NN	denotes	rat
T8118	3068-3071	DT	denotes	the
T8117	3056-3067	VBD	denotes	established
T8116	3053-3055	PRP	denotes	we
T8115	3051-3052	,	denotes	,
T8114	3046-3051	NN	denotes	study
T8113	3038-3045	JJ	denotes	present
T8112	3034-3037	DT	denotes	the
T8111	3031-3033	IN	denotes	In
T8110	3029-3030	.	denotes	.
T8109	3026-3029	NNP	denotes	ICH
T8108	3022-3025	CC	denotes	and
T8107	3012-3021	VBG	denotes	signaling
T8106	3007-3011	NNP	denotes	NFκB
T8105	2993-3006	JJ	denotes	TLR4-mediated
T8104	2985-2992	IN	denotes	between
T8103	2972-2984	NN	denotes	relationship
T8102	2968-2971	DT	denotes	the
T8101	2964-2967	CC	denotes	and
T8100	2959-2963	NN	denotes	role
T8099	2955-2958	DT	denotes	the
T8098	2943-2954	VB	denotes	investigate
T8097	2940-2942	TO	denotes	to
T8096	2931-2939	VBN	denotes	directed
T8095	2926-2930	VBN	denotes	been
T8094	2921-2925	VBP	denotes	have
T8093	2913-2920	NNS	denotes	studies
T8092	2909-2912	JJ	denotes	few
T8091	2904-2908	RB	denotes	very
T8090	2902-2903	,	denotes	,
T8089	2901-2902	NNP	denotes	]
T8088	2899-2901	CD	denotes	17
T8087	2898-2899	NNP	denotes	[
T8086	2885-2897	NNS	denotes	constituents
T8085	2878-2884	NN	denotes	plasma
T8084	2871-2877	CC	denotes	and/or
T8083	2865-2870	NNS	denotes	cells
T8082	2859-2864	NN	denotes	blood
T8081	2855-2858	JJ	denotes	red
T8080	2852-2854	IN	denotes	by
T8079	2844-2851	VBN	denotes	induced
T8078	2833-2843	NN	denotes	activation
T8077	2824-2832	NN	denotes	receptor
T8076	2814-2823	NN	denotes	glutamate
T8075	2811-2813	CC	denotes	or
T8074	2804-2810	NN	denotes	stress
T8073	2794-2803	JJ	denotes	oxidative
T8072	2790-2793	DT	denotes	the
T8071	2787-2789	TO	denotes	to
T8070	2776-2786	VBN	denotes	attributed
T8069	2772-2775	VBD	denotes	was
T8068	2767-2771	NNP	denotes	NFκB
T8067	2764-2766	IN	denotes	of
T8066	2753-2763	NN	denotes	activation
T8065	2749-2752	DT	denotes	the
T8064	2744-2748	IN	denotes	that
T8063	2734-2743	VBD	denotes	indicated
T8062	2726-2733	NNS	denotes	reports
T8061	2717-2725	JJ	denotes	previous
T8060	2708-2716	IN	denotes	Although
T8059	2706-2707	.	denotes	.
T8058	2705-2706	NN	denotes	]
T8057	2704-2705	CD	denotes	8
T8056	2702-2703	,	denotes	,
T8055	2701-2702	CD	denotes	7
T8054	2700-2701	NN	denotes	[
T8053	2693-2699	NN	denotes	injury
T8052	2684-2692	JJ	denotes	ischemic
T8051	2675-2683	JJ	denotes	cerebral
T8050	2671-2674	CC	denotes	and
T8049	2662-2670	NNS	denotes	diseases
T8048	2658-2661	NNP	denotes	CNS
T8047	2647-2657	JJ	denotes	autoimmune
T8584	5870-5873	CC	denotes	and
T8583	5859-5869	VBN	denotes	determined
T8582	5854-5858	VBN	denotes	been
T8581	5850-5853	RB	denotes	not
T8580	5845-5849	VBP	denotes	have
T8579	5839-5844	NN	denotes	brain
T8578	5827-5838	JJ	denotes	hemorrhagic
T8577	5824-5826	IN	denotes	in
T8576	5819-5823	CD	denotes	TLR4
T8575	5815-5818	IN	denotes	for
T8574	5807-5814	NNS	denotes	ligands
T8573	5796-5806	JJ	denotes	endogenous
T8572	5787-5795	JJ	denotes	specific
T8571	5783-5786	DT	denotes	the
T8570	5781-5782	,	denotes	,
T8569	5774-5781	RB	denotes	However
T8568	5772-5773	.	denotes	.
T8567	5767-5772	NN	denotes	brain
T8566	5763-5766	NNP	denotes	IHC
T8565	5760-5762	IN	denotes	in
T8564	5750-5759	NNS	denotes	responses
T8563	5737-5749	JJ	denotes	inflammatory
T8562	5733-5736	DT	denotes	the
T8561	5724-5732	VB	denotes	initiate
T8560	5720-5723	CC	denotes	and
T8559	5718-5719	,	denotes	,
T8558	5709-5718	VBG	denotes	signaling
T8557	5704-5708	NNP	denotes	NFκB
T8556	5690-5703	JJ	denotes	TLR4-mediated
T8555	5681-5689	VBP	denotes	activate
T8554	5679-5680	,	denotes	,
T8553	5672-5679	NNS	denotes	ligands
T8552	5667-5671	CD	denotes	TLR4
T8551	5656-5666	JJ	denotes	endogenous
T8550	5653-5655	IN	denotes	as
T8549	5646-5652	NN	denotes	server
T8548	5639-5645	NN	denotes	plasma
T8547	5636-5638	IN	denotes	of
T8546	5623-5635	NNS	denotes	constituents
T8545	5619-5622	CC	denotes	and
T8544	5613-5618	NNS	denotes	cells
T8543	5607-5612	NN	denotes	blood
T8542	5602-5606	IN	denotes	from
T8541	5597-5601	VBD	denotes	came
T8540	5594-5596	CC	denotes	or
T8539	5588-5593	NN	denotes	brain
T8538	5580-5587	JJ	denotes	damaged
T8537	5577-5579	IN	denotes	in
T8536	5568-5576	VBN	denotes	produced
T8535	5558-5567	NNS	denotes	molecules
T8534	5552-5557	DT	denotes	these
T8533	5547-5551	IN	denotes	that
T8532	5536-5546	VBN	denotes	speculated
T8531	5533-5535	VB	denotes	be
T8530	5529-5532	MD	denotes	may
T8529	5526-5528	PRP	denotes	It
T8528	5524-5525	.	denotes	.
T8527	5523-5524	NNP	denotes	]
T8526	5521-5523	CD	denotes	21
T8525	5520-5521	NNP	denotes	[
T8046	2644-2646	CC	denotes	or
T8045	2631-2643	JJ	denotes	inflammatory
T8044	2628-2630	IN	denotes	as
T8043	2623-2627	JJ	denotes	such
T8042	2621-2622	,	denotes	,
T8041	2613-2621	NNS	denotes	diseases
T8040	2606-2612	NN	denotes	system
T8039	2604-2605	-RRB-	denotes	)
T8038	2601-2604	NNP	denotes	CNS
T8037	2600-2601	-LRB-	denotes	(
T8036	2592-2599	JJ	denotes	nervous
T8035	2584-2591	JJ	denotes	central
T8034	2576-2583	JJ	denotes	several
T8033	2573-2575	IN	denotes	in
T8032	2564-2572	VBN	denotes	involved
T8031	2561-2563	VB	denotes	be
T8030	2558-2560	TO	denotes	to
T8029	2549-2557	VBN	denotes	reported
T8028	2544-2548	VBN	denotes	been
T8027	2540-2543	VBZ	denotes	has
T8026	2538-2539	,	denotes	,
T8025	2528-2538	VBD	denotes	recognized
T8024	2524-2527	NNP	denotes	TLR
T8023	2514-2523	JJ	denotes	mammalian
T8022	2508-2513	JJ	denotes	first
T8021	2504-2507	DT	denotes	the
T8020	2502-2503	,	denotes	,
T8019	2498-2502	CD	denotes	TLR4
T8018	2496-2497	.	denotes	.
T8017	2495-2496	NN	denotes	]
T8016	2493-2495	CD	denotes	13
T8015	2491-2492	,	denotes	,
T8014	2489-2491	CD	denotes	12
T8013	2488-2489	NNP	denotes	[
T8012	2483-2487	NNP	denotes	NFκB
T8011	2480-2482	IN	denotes	of
T8010	2469-2479	NN	denotes	activation
T8009	2465-2468	DT	denotes	the
T8008	2455-2464	VBP	denotes	stimulate
T8007	2448-2454	RB	denotes	mainly
T8006	2439-2447	NNS	denotes	pathways
T8005	2429-2438	VBG	denotes	signaling
T8004	2416-2428	JJ	denotes	TLR-mediated
T8003	2414-2415	.	denotes	.
T8002	2413-2414	NNP	denotes	]
T8001	2412-2413	CD	denotes	4
T8000	2411-2412	NN	denotes	[
T7999	2402-2410	NN	denotes	immunity
T7998	2393-2401	JJ	denotes	adaptive
T7997	2389-2392	CC	denotes	and
T7996	2382-2388	NN	denotes	innate
T7995	2379-2381	IN	denotes	of
T7957	2162-2171	VBN	denotes	activated
T7956	2159-2161	VBZ	denotes	is
T7955	2154-2158	NNP	denotes	NFκB
T7954	2150-2153	WRB	denotes	how
T7953	2144-2149	IN	denotes	about
T7952	2134-2143	NN	denotes	knowledge
T7951	2130-2133	DT	denotes	The
T7950	2128-2129	.	denotes	.
T7949	2127-2128	NNP	denotes	]
T7948	2125-2127	CD	denotes	17
T7903	1867-1878	VBZ	denotes	contributes
T7902	1863-1866	CC	denotes	and
T7901	1853-1862	NNS	denotes	responses
T7900	1840-1852	JJ	denotes	inflammatory
T7899	1830-1839	VBZ	denotes	initiates
T7898	1825-1829	NNP	denotes	NFκB
T7897	1822-1824	IN	denotes	of
T7896	1811-1821	NNP	denotes	Activation
T7895	1809-1810	.	denotes	.
T7894	1808-1809	NNP	denotes	]
T7893	1806-1808	CD	denotes	15
T7892	1805-1806	NNP	denotes	[
T7891	1799-1804	NNS	denotes	genes
T7890	1792-1798	NN	denotes	target
T7889	1783-1791	VBN	denotes	selected
T7888	1780-1782	IN	denotes	of
T7887	1769-1779	NN	denotes	expression
T7886	1765-1768	DT	denotes	the
T7885	1760-1764	IN	denotes	with
T7884	1749-1759	VBN	denotes	associated
T7883	1746-1748	VBZ	denotes	is
T7882	1740-1745	WDT	denotes	which
T7881	1738-1739	,	denotes	,
T7880	1735-1738	NNP	denotes	ICH
T7879	1732-1734	TO	denotes	to
T7878	1723-1731	NN	denotes	response
T7877	1720-1722	IN	denotes	in
T7876	1715-1719	NN	denotes	week
T7875	1713-1714	DT	denotes	a
T7874	1707-1712	JJS	denotes	least
T7873	1704-1706	IN	denotes	at
T7872	1700-1703	IN	denotes	for
T7871	1691-1699	VBZ	denotes	persists
T7870	1687-1690	CC	denotes	and
T7869	1679-1686	NNS	denotes	minutes
T7868	1672-1678	IN	denotes	within
T7867	1665-1671	VBZ	denotes	occurs
T7866	1654-1664	NN	denotes	activation
T7865	1649-1653	NNP	denotes	NFκB
T7864	1647-1648	.	denotes	.
T7863	1646-1647	NNP	denotes	]
T7862	1644-1646	CD	denotes	14
T7861	1643-1644	NNP	denotes	[
T7860	1639-1642	NNP	denotes	ICH
T7859	1633-1638	IN	denotes	after
T7858	1620-1632	NN	denotes	perihematoma
T7857	1617-1619	IN	denotes	of
T7856	1610-1616	NN	denotes	region
T7855	1606-1609	DT	denotes	the
T7854	1603-1605	IN	denotes	in
T7853	1593-1602	VBD	denotes	increased
T7852	1588-1592	NNP	denotes	NFκB
T7851	1583-1587	IN	denotes	that
T7850	1574-1582	VBN	denotes	reported
T7849	1569-1573	VBN	denotes	been
T7848	1565-1568	VBZ	denotes	has
T7847	1562-1564	PRP	denotes	It
T7846	1560-1561	.	denotes	.
T7845	1549-1560	NNS	denotes	pathologies
T7844	1543-1548	NN	denotes	brain
T7843	1540-1542	IN	denotes	in
T7842	1527-1539	NN	denotes	inflammation
T7841	1516-1526	VBG	denotes	regulating
T7840	1513-1515	IN	denotes	in
T7839	1508-1512	NN	denotes	role
T7838	1504-1507	JJ	denotes	key
T7837	1502-1503	DT	denotes	a
T7836	1496-1501	VBZ	denotes	plays
T7835	1491-1495	RB	denotes	also
T7834	1487-1490	CC	denotes	and
T7833	1485-1486	NN	denotes	]
T7832	1483-1485	CD	denotes	13
T7831	1481-1482	,	denotes	,
T7830	1479-1481	CD	denotes	12
T7829	1478-1479	NNP	denotes	[
T7828	1465-1477	NN	denotes	inflammation
T7827	1461-1464	CC	denotes	and
T7826	1451-1460	NNS	denotes	responses
T7825	1444-1450	JJ	denotes	immune
T7824	1439-1443	IN	denotes	with
T7823	1428-1438	VBN	denotes	associated
T7822	1422-1427	NNS	denotes	genes
T7821	1419-1421	IN	denotes	of
T7820	1405-1418	NN	denotes	transcription
T7819	1395-1404	VBZ	denotes	initiates
T7818	1389-1394	WDT	denotes	which
T7817	1387-1388	,	denotes	,
T7816	1381-1387	NN	denotes	factor
T7815	1367-1380	NN	denotes	transcription
T7814	1359-1366	JJ	denotes	nuclear
T7813	1349-1358	JJ	denotes	important
T7812	1346-1348	DT	denotes	an
T7811	1343-1345	VBZ	denotes	is
T7810	1341-1342	-RRB-	denotes	)
T7809	1337-1341	NNP	denotes	NFκB
T7808	1336-1337	-LRB-	denotes	(
T7807	1321-1335	NNP	denotes	factor-kappa-B
T7806	1313-1320	JJ	denotes	nuclear
T7805	1306-1312	NN	denotes	factor
T7804	1292-1305	NNP	denotes	Transcription
T7803	1290-1291	.	denotes	.
T7802	1283-1290	JJ	denotes	unclear
T7801	1280-1282	VBZ	denotes	is
T7800	1276-1279	NNP	denotes	ICH
T7799	1270-1275	IN	denotes	after
T7798	1263-1269	NN	denotes	tissue
T7797	1257-1262	NN	denotes	brain
T7796	1253-1256	DT	denotes	the
T7795	1250-1252	IN	denotes	in
T7794	1240-1249	VBN	denotes	regulated
T8308	4219-4221	IN	denotes	in
T8307	4214-4218	NNP	denotes	NFκB
T8306	4211-4213	IN	denotes	of
T8305	4202-4210	NN	denotes	activity
T8304	4198-4201	DT	denotes	the
T8303	4194-4197	CC	denotes	and
T8302	4188-4193	NN	denotes	p-IκB
T8301	4184-4187	DT	denotes	the
T8300	4174-4183	VBG	denotes	detecting
T8299	4171-4173	IN	denotes	by
T8298	4161-4170	VBG	denotes	signaling
T8297	4156-4160	NNP	denotes	NFκB
T8296	4142-4155	JJ	denotes	TLR4-mediated
T8295	4139-4141	IN	denotes	of
T8294	4128-4138	NN	denotes	activation
T8293	4124-4127	DT	denotes	the
T8292	4114-4123	VBD	denotes	evaluated
T8291	4111-4113	PRP	denotes	we
T8290	4109-4110	,	denotes	,
T8289	4104-4109	NN	denotes	study
T8288	4096-4103	JJ	denotes	present
T8287	4092-4095	DT	denotes	the
T8286	4089-4091	IN	denotes	in
T8285	4087-4088	,	denotes	,
T8284	4084-4087	NNP	denotes	ICH
T8283	4078-4083	IN	denotes	after
T8282	4072-4077	NN	denotes	brain
T8281	4068-4071	DT	denotes	the
T8280	4065-4067	IN	denotes	in
T8279	4055-4064	NNS	denotes	responses
T8278	4042-4054	JJ	denotes	inflammatory
T8277	4032-4041	VBN	denotes	increased
T8276	4028-4031	DT	denotes	the
T8275	4017-4027	VBG	denotes	underlying
T8274	4006-4016	NNS	denotes	mechanisms
T8273	4002-4005	DT	denotes	the
T8272	3990-4001	VB	denotes	investigate
T8271	3987-3989	TO	denotes	To
T8270	3985-3986	.	denotes	.
T8269	3976-3985	NNS	denotes	responses
T8268	3963-3975	JJ	denotes	inflammatory
T8267	3959-3962	CC	denotes	and
T8266	3945-3958	JJ	denotes	immunological
T8265	3935-3944	VBZ	denotes	regulates
T8264	3931-3934	CC	denotes	and
T8263	3921-3930	NNS	denotes	activates
T8262	3913-3920	NN	denotes	pathway
T8261	3894-3912	JJ	denotes	TLR4-mediated-NFκB
T8260	3889-3893	IN	denotes	that
T8259	3880-3888	VBN	denotes	believed
T8258	3876-3879	RB	denotes	now
T8257	3873-3875	VBZ	denotes	is
T8256	3870-3872	PRP	denotes	It
T8255	3868-3869	.	denotes	.
T8254	3867-3868	NNP	denotes	]
T8253	3865-3867	CD	denotes	18
T8252	3864-3865	NNP	denotes	[
T8251	3858-3863	NN	denotes	death
T8250	3853-3857	NN	denotes	cell
T8249	3849-3852	CC	denotes	and
T8248	3838-3848	NN	denotes	hemorrhage
T8247	3835-3837	IN	denotes	of
T8246	3828-3834	NN	denotes	growth
T8245	3818-3827	JJ	denotes	secondary
T8244	3813-3817	IN	denotes	with
T8243	3802-3812	VBN	denotes	associated
T8242	3798-3801	VBP	denotes	are
T8241	3792-3797	WDT	denotes	which
T8240	3790-3791	,	denotes	,
T8239	3781-3790	NNS	denotes	responses
T8238	3768-3780	JJ	denotes	inflammatory
T8237	3758-3767	VBZ	denotes	initiates
T8236	3754-3757	NNP	denotes	ICH
T8235	3749-3753	IN	denotes	that
T8234	3736-3748	VBD	denotes	demonstrated
T8233	3728-3735	NNS	denotes	studies
T8232	3721-3727	JJ	denotes	Recent
T8231	3719-3720	.	denotes	.
T8230	3716-3719	NNP	denotes	ICH
T8229	3710-3715	IN	denotes	after
T8228	3703-3709	NN	denotes	tissue
T8227	3697-3702	NN	denotes	brain
T8226	3693-3696	DT	denotes	the
T8225	3690-3692	IN	denotes	in
T8224	3680-3689	NNS	denotes	responses
T8223	3667-3679	JJ	denotes	inflammatory
T8222	3663-3666	DT	denotes	the
T8221	3660-3662	IN	denotes	of
T8220	3649-3659	VBG	denotes	triggering
T8219	3645-3648	DT	denotes	the
T8218	3642-3644	TO	denotes	to
T8217	3634-3641	VBN	denotes	related
T8216	3631-3633	VB	denotes	be
T8215	3627-3630	MD	denotes	may
T8214	3622-3626	CD	denotes	TLR4
T8213	3619-3621	IN	denotes	of
T8212	3608-3618	NN	denotes	expression
T8211	3598-3607	VBN	denotes	increased
T7793	1236-1239	CC	denotes	and
T7792	1226-1235	VBN	denotes	activated
T7791	1223-1225	VBZ	denotes	is
T7790	1213-1222	NNS	denotes	responses
T7789	1200-1212	JJ	denotes	inflammatory
T7788	1196-1199	DT	denotes	the
T7787	1192-1195	WRB	denotes	how
T7786	1190-1191	,	denotes	,
T7785	1183-1190	RB	denotes	However
T7784	1181-1182	.	denotes	.
T7783	1178-1181	NNP	denotes	ICH
T7782	1175-1177	IN	denotes	of
T7781	1162-1174	NN	denotes	pathogenesis
T7780	1158-1161	DT	denotes	the
T7779	1155-1157	IN	denotes	in
T7778	1145-1154	JJ	denotes	important
T7777	1142-1144	VB	denotes	be
T7776	1138-1141	MD	denotes	may
T7775	1136-1137	,	denotes	,
T7774	1126-1136	VBP	denotes	complement
T7773	1122-1125	CC	denotes	and
T7772	1120-1121	,	denotes	,
T7771	1105-1120	NNS	denotes	immunoglobulins
T7770	1103-1104	,	denotes	,
T7769	1093-1103	NNS	denotes	leukocytes
T7768	1091-1092	,	denotes	,
T7767	1082-1091	NNS	denotes	cytokines
T7766	1080-1081	,	denotes	,
T7765	1071-1080	NNS	denotes	molecules
T7764	1062-1070	NN	denotes	adhesion
T7763	1052-1061	VBG	denotes	including
T7762	1050-1051	,	denotes	,
T7761	1042-1050	NN	denotes	response
T7760	1029-1041	JJ	denotes	inflammatory
T7759	1025-1028	DT	denotes	the
T7758	1022-1024	IN	denotes	of
T7757	1009-1021	NNS	denotes	constituents
T7756	1001-1008	JJ	denotes	Various
T7755	999-1000	.	denotes	.
T7754	996-999	NNP	denotes	ICH
T7753	992-995	IN	denotes	for
T7752	984-991	NNS	denotes	targets
T7751	972-983	JJ	denotes	therapeutic
T7750	968-971	JJ	denotes	new
T7749	960-967	VB	denotes	provide
T7748	954-959	MD	denotes	could
T7747	948-953	WDT	denotes	which
T7746	946-947	,	denotes	,
T7745	940-946	NN	denotes	injury
T7744	934-939	NN	denotes	brain
T7743	926-933	VBD	denotes	induced
T7742	922-925	NNP	denotes	ICH
T7994	2369-2378	NN	denotes	induction
T7993	2365-2368	DT	denotes	the
T7992	2362-2364	IN	denotes	in
T7991	2357-2361	NN	denotes	role
T7990	2348-2356	JJ	denotes	critical
T7989	2346-2347	DT	denotes	a
T7988	2341-2345	VB	denotes	play
T7987	2337-2340	CC	denotes	and
T7986	2327-2336	NNS	denotes	molecules
T7985	2314-2326	NN	denotes	transduction
T7984	2307-2313	NN	denotes	signal
T7983	2304-2306	IN	denotes	of
T7982	2297-2303	NN	denotes	family
T7981	2295-2296	DT	denotes	a
T7980	2291-2294	VBP	denotes	are
T7979	2289-2290	-RRB-	denotes	)
T7978	2285-2289	NNS	denotes	TLRs
T7977	2284-2285	-LRB-	denotes	(
T7976	2274-2283	NNS	denotes	receptors
T7975	2264-2273	JJ	denotes	Toll-like
T7974	2262-2263	.	denotes	.
T7973	2259-2262	NNP	denotes	ICH
T7972	2255-2258	IN	denotes	for
T7971	2248-2254	NN	denotes	method
T7970	2232-2247	JJ	denotes	neuroprotective
T7969	2228-2231	JJ	denotes	new
T7968	2226-2227	DT	denotes	a
T7967	2218-2225	VBG	denotes	seeking
T7966	2214-2217	IN	denotes	for
T7965	2205-2213	JJ	denotes	critical
T7964	2202-2204	VBZ	denotes	is
T7963	2198-2201	NNP	denotes	ICH
T7962	2195-2197	TO	denotes	to
T7961	2185-2194	VBN	denotes	subjected
T7960	2179-2184	NN	denotes	brain
T7959	2175-2178	DT	denotes	the
T7958	2172-2174	IN	denotes	in
T7726	834-843	VBG	denotes	producing
T7725	831-833	IN	denotes	of
T7724	823-830	JJ	denotes	capable
T7723	818-822	RB	denotes	also
T7722	814-817	VBP	denotes	are
T7721	807-813	PRP	denotes	itself
T7720	801-806	NNS	denotes	cells
T7719	795-800	NN	denotes	brain
T7718	791-794	DT	denotes	the
T7717	787-790	CC	denotes	and
T7716	778-786	NN	denotes	reaction
T7715	765-777	JJ	denotes	inflammatory
T7714	762-764	DT	denotes	an
T7713	755-761	VB	denotes	induce
T7712	751-754	CC	denotes	and
T7711	745-750	NN	denotes	brain
T7710	741-744	DT	denotes	the
T7709	738-740	TO	denotes	to
T7708	732-737	VB	denotes	enter
T7707	726-731	MD	denotes	might
T7706	720-725	NN	denotes	blood
T7705	716-719	DT	denotes	the
T7704	711-715	IN	denotes	from
T7703	701-710	NNS	denotes	mediators
T7702	688-700	JJ	denotes	inflammatory
T7701	686-687	,	denotes	,
T7700	683-686	NNP	denotes	ICH
T7699	677-682	IN	denotes	After
T7698	675-676	.	denotes	.
T7697	669-675	NNS	denotes	events
T7696	653-668	JJ	denotes	cerebrovascular
T7695	650-652	IN	denotes	in
T7694	641-649	VBN	denotes	involved
T7693	637-640	VBP	denotes	are
T7692	627-636	NNS	denotes	processes
T7691	614-626	JJ	denotes	inflammatory
T7690	609-613	IN	denotes	that
T7689	600-608	NN	denotes	evidence
T7688	589-599	VBG	denotes	increasing
T7687	586-588	VBZ	denotes	is
T7686	580-585	EX	denotes	there
T7685	578-579	,	denotes	,
T7684	570-578	NN	denotes	addition
T7683	567-569	IN	denotes	In
T7682	565-566	.	denotes	.
T7681	559-565	NN	denotes	damage
T7680	552-558	NN	denotes	tissue
T7679	546-551	NN	denotes	brain
T7678	539-545	VB	denotes	induce
T7677	535-538	NNP	denotes	ICH
T7676	529-534	IN	denotes	after
T7675	518-528	NNS	denotes	components
T7674	512-517	NN	denotes	blood
T7673	509-511	IN	denotes	of
T7672	500-508	NN	denotes	toxicity
T7671	496-499	CC	denotes	and
T7670	494-495	,	denotes	,
T7669	486-494	NN	denotes	ischemia
T7668	484-485	,	denotes	,
T7667	478-484	NN	denotes	effect
T7666	473-477	NNP	denotes	Mass
T7665	471-472	.	denotes	.
T7664	462-471	JJ	denotes	effective
T7663	458-461	RB	denotes	not
T7662	454-457	VBP	denotes	are
T7661	450-453	NNP	denotes	ICH
T7660	444-449	IN	denotes	after
T7659	437-443	NN	denotes	tissue
T7658	431-436	NN	denotes	brain
T7657	427-430	DT	denotes	the
T7656	424-426	IN	denotes	of
T7655	413-423	NN	denotes	protection
T7654	409-412	CC	denotes	and
T7653	401-408	NN	denotes	disease
T7652	396-400	DT	denotes	this
T7651	393-395	IN	denotes	of
T7650	383-392	NN	denotes	treatment
T7649	379-382	IN	denotes	for
T7648	372-378	NN	denotes	method
T7647	368-371	DT	denotes	the
T7646	366-367	,	denotes	,
T7645	353-366	RB	denotes	Unfortunately
T7644	351-352	.	denotes	.
T7643	350-351	NNP	denotes	]
T7642	348-350	CD	denotes	10
T7641	347-348	NNP	denotes	[
T7640	342-346	NN	denotes	year
T7639	338-341	CD	denotes	1st
T7638	334-337	DT	denotes	the
T7637	326-333	VBP	denotes	survive
T7636	317-325	NNS	denotes	patients
T7635	313-316	DT	denotes	the
T7634	310-312	IN	denotes	of
T7633	308-309	NN	denotes	%
T7632	306-308	CD	denotes	38
T7631	301-305	RB	denotes	Only
T7630	299-300	.	denotes	.
T7629	293-299	NNS	denotes	months
T7628	291-292	CD	denotes	3
T7627	288-290	IN	denotes	at
T7626	276-287	JJ	denotes	independent
T7625	263-275	RB	denotes	functionally
T7624	259-262	VBP	denotes	are
T7623	257-258	NN	denotes	%
T7622	255-257	CD	denotes	31
T7621	250-254	RB	denotes	Only
T7620	248-249	.	denotes	.
T7619	242-248	NN	denotes	stroke
T7618	233-241	JJ	denotes	ischemic
T7617	230-232	IN	denotes	of
T7616	225-229	DT	denotes	that
T7615	220-224	IN	denotes	than
T7614	213-219	JJR	denotes	higher
T7613	210-212	VBZ	denotes	is
T7612	206-209	NNP	denotes	ICH
T7611	203-205	IN	denotes	of
T7610	193-202	NN	denotes	mortality
T7609	189-192	DT	denotes	The
T7608	187-188	.	denotes	.
T7607	186-187	NNP	denotes	]
T7606	185-186	CD	denotes	1
T7605	184-185	NNP	denotes	[
T7604	177-183	NN	denotes	stroke
T7603	168-176	JJ	denotes	ischemic
T7602	165-167	IN	denotes	of
T7601	155-164	NN	denotes	treatment
T7600	142-154	JJ	denotes	thrombolytic
T7599	138-141	DT	denotes	the
T7598	135-137	IN	denotes	of
T7597	122-134	NN	denotes	complication
T7596	120-121	DT	denotes	a
T7595	117-119	IN	denotes	as
T7594	107-116	NN	denotes	frequency
T7593	96-106	VBG	denotes	increasing
T7592	91-95	IN	denotes	with
T7591	84-90	VBZ	denotes	occurs
T7590	80-83	CC	denotes	and
T7589	78-79	,	denotes	,
T7588	71-78	NNS	denotes	strokes
T7587	67-70	DT	denotes	all
T7586	64-66	IN	denotes	of
T7585	62-63	NN	denotes	%
T7584	60-62	CD	denotes	15
T7583	57-59	CD	denotes	10
T7582	46-56	VBZ	denotes	represents
T7581	44-45	-RRB-	denotes	)
T7580	41-44	NNP	denotes	ICH
T7579	40-41	-LRB-	denotes	(
T7578	29-39	NN	denotes	hemorrhage
T7577	14-28	JJ	denotes	Intra-cerebral
T7741	918-921	DT	denotes	the
T7740	914-917	IN	denotes	for
T7739	902-913	JJ	denotes	responsible
T7738	898-901	VBP	denotes	are
T7737	888-897	NNS	denotes	responses
T7736	875-887	JJ	denotes	inflammatory
T7735	871-874	DT	denotes	The
T7734	869-870	.	denotes	.
T7733	868-869	NNP	denotes	]
T7732	866-868	CD	denotes	11
T7731	865-866	NNP	denotes	[
T7730	858-864	NNS	denotes	agents
T7729	852-857	DT	denotes	these
T7728	849-851	IN	denotes	of
T7727	844-848	JJ	denotes	many
T7947	2124-2125	NNP	denotes	[
T7946	2120-2123	NNP	denotes	ICH
T7945	2117-2119	IN	denotes	by
T7944	2108-2116	VBN	denotes	produced
T7943	2101-2107	NN	denotes	damage
T7942	2092-2100	JJ	denotes	neuronal
T7941	2088-2091	CC	denotes	and
T7940	2086-2087	,	denotes	,
T7939	2075-2086	NN	denotes	dysfunction
T7938	2064-2074	JJ	denotes	behavioral
T7937	2062-2063	,	denotes	,
T7936	2050-2062	NN	denotes	inflammation
T7935	2043-2049	VB	denotes	reduce
T7934	2040-2042	IN	denotes	as
T7933	2035-2039	JJ	denotes	such
T7932	2033-2034	,	denotes	,
T7931	2030-2033	NNP	denotes	ICH
T7930	2017-2029	JJ	denotes	experimental
T7929	2014-2016	IN	denotes	on
T7928	2007-2013	NN	denotes	effect
T7927	1995-2006	JJ	denotes	therapeutic
T7926	1993-1994	DT	denotes	a
T7925	1988-1992	VB	denotes	have
T7924	1985-1987	TO	denotes	to
T7923	1979-1984	VBN	denotes	shown
T7922	1974-1978	VBN	denotes	been
T7921	1970-1973	VBZ	denotes	has
T7920	1961-1969	NN	denotes	activity
T7919	1956-1960	NNP	denotes	NFκB
T7918	1953-1955	IN	denotes	of
T7917	1942-1952	NNP	denotes	Inhibition
T7916	1940-1941	.	denotes	.
T7915	1939-1940	NNP	denotes	]
T7914	1937-1939	CD	denotes	16
T7913	1936-1937	NNP	denotes	[
T7912	1932-1935	NNP	denotes	ICH
T7911	1926-1931	IN	denotes	after
T7910	1920-1925	NN	denotes	death
T7909	1915-1919	NN	denotes	cell
T7908	1902-1914	JJ	denotes	perilesional
T7907	1899-1901	IN	denotes	of
T7906	1886-1898	NN	denotes	pathobiology
T7905	1882-1885	DT	denotes	the
T7904	1879-1881	TO	denotes	to
R5777	T7577	T7578	amod	Intra-cerebral,hemorrhage
R5778	T7578	T7582	nsubj	hemorrhage,represents
R5779	T7579	T7580	punct	(,ICH
R5780	T7580	T7578	appos	ICH,hemorrhage
R5781	T7581	T7578	punct	),hemorrhage
R5782	T7582	T7582	ROOT	represents,represents
R5783	T7583	T7582	dobj	10,represents
R5784	T7584	T7585	nummod	15,%
R5785	T7585	T7583	appos	%,10
R5786	T7586	T7585	prep	of,%
R5787	T7587	T7588	det	all,strokes
R5788	T7588	T7586	pobj	strokes,of
R5789	T7589	T7582	punct	",",represents
R5790	T7590	T7582	cc	and,represents
R5791	T7591	T7582	conj	occurs,represents
R5792	T7592	T7591	prep	with,occurs
R5793	T7593	T7594	amod	increasing,frequency
R5794	T7594	T7592	pobj	frequency,with
R5795	T7595	T7594	prep	as,frequency
R5796	T7596	T7597	det	a,complication
R5797	T7597	T7595	pobj	complication,as
R5798	T7598	T7597	prep	of,complication
R5799	T7599	T7601	det	the,treatment
R5800	T7600	T7601	compound	thrombolytic,treatment
R5801	T7601	T7598	pobj	treatment,of
R5802	T7602	T7601	prep	of,treatment
R5803	T7603	T7604	amod	ischemic,stroke
R5804	T7604	T7602	pobj	stroke,of
R5805	T7605	T7607	nmod	[,]
R5806	T7606	T7607	nummod	1,]
R5807	T7607	T7597	appos	],complication
R5808	T7608	T7582	punct	.,represents
R5809	T7609	T7610	det	The,mortality
R5810	T7610	T7613	nsubj	mortality,is
R5811	T7611	T7610	prep	of,mortality
R5812	T7612	T7611	pobj	ICH,of
R5813	T7613	T7613	ROOT	is,is
R5814	T7614	T7613	acomp	higher,is
R5815	T7615	T7614	prep	than,higher
R5816	T7616	T7615	pobj	that,than
R5817	T7617	T7616	prep	of,that
R5818	T7618	T7619	amod	ischemic,stroke
R5819	T7619	T7617	pobj	stroke,of
R5820	T7620	T7613	punct	.,is
R5821	T7621	T7622	advmod	Only,31
R5822	T7622	T7623	nummod	31,%
R5823	T7623	T7624	nsubj	%,are
R5824	T7624	T7624	ROOT	are,are
R5825	T7625	T7626	advmod	functionally,independent
R5826	T7626	T7624	acomp	independent,are
R5827	T7627	T7624	prep	at,are
R5828	T7628	T7629	nummod	3,months
R5829	T7629	T7627	pobj	months,at
R5830	T7630	T7624	punct	.,are
R5831	T7631	T7632	advmod	Only,38
R5832	T7632	T7633	nummod	38,%
R5833	T7633	T7637	nsubj	%,survive
R5834	T7634	T7633	prep	of,%
R5835	T7635	T7636	det	the,patients
R5836	T7636	T7634	pobj	patients,of
R5837	T7637	T7637	ROOT	survive,survive
R5838	T7638	T7640	det	the,year
R5839	T7639	T7640	amod	1st,year
R5840	T7640	T7637	dobj	year,survive
R5841	T7641	T7643	nmod	[,]
R5842	T7642	T7643	nummod	10,]
R5843	T7643	T7640	appos	],year
R5844	T7644	T7637	punct	.,survive
R5845	T7645	T7662	advmod	Unfortunately,are
R5846	T7646	T7662	punct	",",are
R5847	T7647	T7648	det	the,method
R5848	T7648	T7662	nsubj	method,are
R5849	T7649	T7648	prep	for,method
R5850	T7650	T7649	pobj	treatment,for
R5851	T7651	T7650	prep	of,treatment
R5852	T7652	T7653	det	this,disease
R5853	T7653	T7651	pobj	disease,of
R5854	T7654	T7653	cc	and,disease
R5855	T7655	T7653	conj	protection,disease
R5856	T7656	T7655	prep	of,protection
R5857	T7657	T7659	det	the,tissue
R5858	T7658	T7659	compound	brain,tissue
R5859	T7659	T7656	pobj	tissue,of
R5860	T7660	T7648	prep	after,method
R5861	T7661	T7660	pobj	ICH,after
R5862	T7662	T7662	ROOT	are,are
R5863	T7663	T7662	neg	not,are
R5864	T7664	T7662	acomp	effective,are
R5865	T7665	T7662	punct	.,are
R5866	T7666	T7667	compound	Mass,effect
R5867	T7667	T7667	ROOT	effect,effect
R5868	T7668	T7669	punct	",",ischemia
R5869	T7669	T7667	conj	ischemia,effect
R5870	T7670	T7669	punct	",",ischemia
R5871	T7671	T7669	cc	and,ischemia
R5872	T7672	T7669	conj	toxicity,ischemia
R5873	T7673	T7672	prep	of,toxicity
R5874	T7674	T7675	compound	blood,components
R5875	T7675	T7673	pobj	components,of
R5876	T7676	T7678	mark	after,induce
R5877	T7677	T7678	nsubj	ICH,induce
R5878	T7678	T7667	advcl	induce,effect
R5880	T7680	T7681	compound	tissue,damage
R5881	T7681	T7678	dobj	damage,induce
R5882	T7682	T7667	punct	.,effect
R5883	T7683	T7688	prep	In,increasing
R5884	T7684	T7683	pobj	addition,In
R5885	T7685	T7688	punct	",",increasing
R5886	T7686	T7687	expl	there,is
R5887	T7687	T7688	aux	is,increasing
R5888	T7688	T7688	ROOT	increasing,increasing
R5889	T7689	T7688	dobj	evidence,increasing
R5890	T7690	T7694	mark	that,involved
R5891	T7691	T7692	amod	inflammatory,processes
R5892	T7692	T7694	nsubjpass	processes,involved
R5893	T7693	T7694	auxpass	are,involved
R5894	T7694	T7689	acl	involved,evidence
R5895	T7695	T7694	prep	in,involved
R5896	T7696	T7697	amod	cerebrovascular,events
R5897	T7697	T7695	pobj	events,in
R5898	T7698	T7688	punct	.,increasing
R5899	T7699	T7708	prep	After,enter
R5900	T7700	T7699	pobj	ICH,After
R5901	T7701	T7708	punct	",",enter
R5902	T7702	T7703	amod	inflammatory,mediators
R5903	T7703	T7708	nsubj	mediators,enter
R5904	T7704	T7703	prep	from,mediators
R5905	T7705	T7706	det	the,blood
R5906	T7706	T7704	pobj	blood,from
R5907	T7707	T7708	aux	might,enter
R5908	T7708	T7708	ROOT	enter,enter
R5909	T7709	T7708	prep	to,enter
R5910	T7710	T7711	det	the,brain
R5911	T7711	T7709	pobj	brain,to
R5912	T7712	T7708	cc	and,enter
R5913	T7713	T7708	conj	induce,enter
R5914	T7714	T7716	det	an,reaction
R5915	T7715	T7716	amod	inflammatory,reaction
R5916	T7716	T7713	dobj	reaction,induce
R5917	T7717	T7716	cc	and,reaction
R5918	T7718	T7720	det	the,cells
R5919	T7719	T7720	compound	brain,cells
R5920	T7720	T7716	conj	cells,reaction
R5921	T7721	T7720	appos	itself,cells
R5922	T7722	T7708	conj	are,enter
R5923	T7723	T7722	advmod	also,are
R5924	T7724	T7722	acomp	capable,are
R5925	T7725	T7724	prep	of,capable
R5926	T7726	T7725	pcomp	producing,of
R5927	T7727	T7726	dobj	many,producing
R5928	T7728	T7727	prep	of,many
R5929	T7729	T7730	det	these,agents
R5930	T7730	T7728	pobj	agents,of
R5931	T7731	T7733	nmod	[,]
R5932	T7732	T7733	nummod	11,]
R5933	T7733	T7726	dobj	],producing
R5934	T7734	T7722	punct	.,are
R5935	T7735	T7737	det	The,responses
R5936	T7736	T7737	amod	inflammatory,responses
R5937	T7737	T7738	nsubj	responses,are
R5939	T7738	T7738	ROOT	are,are
R5941	T7739	T7738	acomp	responsible,are
R5944	T7740	T7739	prep	for,responsible
R5948	T7741	T7742	det	the,ICH
R5952	T7742	T7743	nsubj	ICH,induced
R5955	T7743	T7738	advcl	induced,are
R5956	T7819	T7816	relcl	initiates,factor
R5957	T7820	T7819	dobj	transcription,initiates
R5958	T7821	T7820	prep	of,transcription
R5959	T7822	T7821	pobj	genes,of
R5960	T7744	T7745	compound	brain,injury
R5961	T7823	T7822	acl	associated,genes
R5962	T7745	T7743	dobj	injury,induced
R5964	T7746	T7745	punct	",",injury
R5965	T7825	T7826	amod	immune,responses
R5966	T7826	T7824	pobj	responses,with
R5967	T7747	T7749	nsubj	which,provide
R5968	T7827	T7826	cc	and,responses
R5969	T7828	T7826	conj	inflammation,responses
R5970	T7829	T7833	nmod	[,]
R5971	T7830	T7832	dep	12,13
R5972	T7831	T7832	punct	",",13
R5973	T7832	T7833	nummod	13,]
R5974	T7748	T7749	aux	could,provide
R5975	T7833	T7836	nsubj	],plays
R5976	T7834	T7833	cc	and,]
R5977	T7749	T7745	relcl	provide,injury
R5978	T7835	T7836	advmod	also,plays
R5979	T7836	T7836	ROOT	plays,plays
R5980	T7837	T7839	det	a,role
R5981	T7838	T7839	amod	key,role
R5982	T7750	T7752	amod	new,targets
R5983	T7839	T7836	dobj	role,plays
R5984	T7840	T7839	prep	in,role
R5985	T7841	T7840	pcomp	regulating,in
R5986	T7751	T7752	amod	therapeutic,targets
R5987	T7842	T7841	dobj	inflammation,regulating
R5988	T7843	T7842	prep	in,inflammation
R5989	T7752	T7749	dobj	targets,provide
R5990	T7844	T7845	compound	brain,pathologies
R5991	T7845	T7843	pobj	pathologies,in
R5992	T7846	T7836	punct	.,plays
R5993	T7847	T7850	nsubjpass	It,reported
R5994	T7753	T7752	prep	for,targets
R5995	T7848	T7850	aux	has,reported
R5996	T7849	T7850	auxpass	been,reported
R5997	T7850	T7850	ROOT	reported,reported
R5998	T7754	T7753	pobj	ICH,for
R5999	T7851	T7853	mark	that,increased
R6000	T7852	T7853	nsubj	NFκB,increased
R6001	T7853	T7850	ccomp	increased,reported
R6002	T7755	T7738	punct	.,are
R6003	T7854	T7853	prep	in,increased
R6004	T7855	T7856	det	the,region
R6005	T7856	T7854	pobj	region,in
R6006	T7756	T7757	amod	Various,constituents
R6007	T7857	T7856	prep	of,region
R6008	T7858	T7857	pobj	perihematoma,of
R6009	T7859	T7853	prep	after,increased
R6010	T7757	T7777	nsubj	constituents,be
R6011	T7860	T7861	compound	ICH,[
R6012	T7861	T7859	pobj	[,after
R6013	T7862	T7863	nummod	14,]
R6014	T7758	T7757	prep	of,constituents
R6015	T7863	T7861	appos	],[
R6016	T7864	T7850	punct	.,reported
R6017	T7865	T7866	compound	NFκB,activation
R6018	T7866	T7867	nsubj	activation,occurs
R6019	T7867	T7867	ROOT	occurs,occurs
R6020	T7868	T7867	prep	within,occurs
R6021	T7869	T7868	pobj	minutes,within
R6022	T7759	T7761	det	the,response
R6023	T7870	T7867	cc	and,occurs
R6024	T7871	T7867	conj	persists,occurs
R6025	T7872	T7871	prep	for,persists
R6026	T7873	T7874	advmod	at,least
R6027	T7760	T7761	amod	inflammatory,response
R6028	T7874	T7875	advmod	least,a
R6029	T7875	T7876	nummod	a,week
R6030	T7761	T7758	pobj	response,of
R6031	T7876	T7872	pobj	week,for
R6032	T7877	T7871	prep	in,persists
R6033	T7878	T7877	pobj	response,in
R6034	T7762	T7757	punct	",",constituents
R6035	T7879	T7878	prep	to,response
R6036	T7880	T7879	pobj	ICH,to
R6037	T7881	T7880	punct	",",ICH
R6038	T7882	T7884	nsubjpass	which,associated
R6039	T7763	T7757	prep	including,constituents
R6040	T7883	T7884	auxpass	is,associated
R6041	T7884	T7880	relcl	associated,ICH
R6042	T7885	T7884	prep	with,associated
R6043	T7764	T7765	compound	adhesion,molecules
R6044	T7886	T7887	det	the,expression
R6045	T7887	T7885	pobj	expression,with
R6046	T7888	T7887	prep	of,expression
R6047	T7765	T7763	pobj	molecules,including
R6048	T7889	T7891	amod	selected,genes
R6049	T7890	T7891	compound	target,genes
R6050	T7891	T7888	pobj	genes,of
R6051	T7766	T7765	punct	",",molecules
R6052	T7892	T7894	nmod	[,]
R6053	T7893	T7894	nummod	15,]
R6054	T7894	T7887	appos	],expression
R6055	T7767	T7765	conj	cytokines,molecules
R6056	T7895	T7867	punct	.,occurs
R6057	T7896	T7899	nsubj	Activation,initiates
R6058	T7897	T7896	prep	of,Activation
R6059	T7768	T7767	punct	",",cytokines
R6060	T7898	T7897	pobj	NFκB,of
R6061	T7899	T7899	ROOT	initiates,initiates
R6062	T7900	T7901	amod	inflammatory,responses
R6063	T7769	T7767	conj	leukocytes,cytokines
R6064	T7901	T7899	dobj	responses,initiates
R6065	T7770	T7769	punct	",",leukocytes
R6066	T7902	T7899	cc	and,initiates
R6067	T7903	T7899	conj	contributes,initiates
R6068	T7771	T7769	conj	immunoglobulins,leukocytes
R6069	T7772	T7771	punct	",",immunoglobulins
R6070	T7904	T7903	prep	to,contributes
R6071	T7773	T7771	cc	and,immunoglobulins
R6072	T7905	T7906	det	the,pathobiology
R6073	T7906	T7904	pobj	pathobiology,to
R6074	T7907	T7906	prep	of,pathobiology
R6075	T7774	T7771	conj	complement,immunoglobulins
R6076	T7908	T7910	amod	perilesional,death
R6077	T7909	T7910	compound	cell,death
R6078	T7775	T7774	punct	",",complement
R6079	T7910	T7907	pobj	death,of
R6080	T7911	T7903	prep	after,contributes
R6081	T7776	T7777	aux	may,be
R6082	T7912	T7915	nmod	ICH,]
R6083	T7913	T7915	nmod	[,]
R6084	T7914	T7915	nummod	16,]
R6085	T7777	T7777	ROOT	be,be
R6086	T7915	T7911	pobj	],after
R6087	T7916	T7899	punct	.,initiates
R6088	T7917	T7923	nsubjpass	Inhibition,shown
R6089	T7778	T7777	acomp	important,be
R6090	T7918	T7917	prep	of,Inhibition
R6091	T7919	T7920	compound	NFκB,activity
R6092	T7920	T7918	pobj	activity,of
R6093	T7779	T7777	prep	in,be
R6094	T7921	T7923	aux	has,shown
R6095	T7922	T7923	auxpass	been,shown
R6096	T7923	T7923	ROOT	shown,shown
R6097	T7780	T7781	det	the,pathogenesis
R6098	T7924	T7925	aux	to,have
R6099	T7925	T7923	xcomp	have,shown
R6100	T7926	T7928	det	a,effect
R6101	T7781	T7779	pobj	pathogenesis,in
R6102	T7927	T7928	amod	therapeutic,effect
R6103	T7928	T7925	dobj	effect,have
R6104	T7929	T7928	prep	on,effect
R6105	T7782	T7781	prep	of,pathogenesis
R6106	T7930	T7931	amod	experimental,ICH
R6107	T7931	T7929	pobj	ICH,on
R6108	T7932	T7928	punct	",",effect
R6109	T7783	T7782	pobj	ICH,of
R6110	T7933	T7934	amod	such,as
R6111	T7934	T7928	prep	as,effect
R6112	T7935	T7934	pobj	reduce,as
R6113	T7784	T7777	punct	.,be
R6114	T7936	T7935	dobj	inflammation,reduce
R6115	T7937	T7936	punct	",",inflammation
R6116	T7938	T7939	amod	behavioral,dysfunction
R6117	T7785	T7792	advmod	However,activated
R6118	T7939	T7936	conj	dysfunction,inflammation
R6119	T7940	T7939	punct	",",dysfunction
R6120	T7941	T7939	cc	and,dysfunction
R6121	T7942	T7943	amod	neuronal,damage
R6122	T7943	T7939	conj	damage,dysfunction
R6123	T7944	T7943	acl	produced,damage
R6124	T7786	T7792	punct	",",activated
R6125	T7945	T7944	agent	by,produced
R6126	T7946	T7947	compound	ICH,[
R6127	T7947	T7945	pobj	[,by
R6128	T7787	T7792	advmod	how,activated
R6129	T7948	T7949	nummod	17,]
R6130	T7949	T7947	appos	],[
R6131	T7950	T7923	punct	.,shown
R6132	T7788	T7790	det	the,responses
R6133	T7951	T7952	det	The,knowledge
R6134	T7952	T7961	nsubj	knowledge,subjected
R6135	T7953	T7952	prep	about,knowledge
R6136	T7789	T7790	amod	inflammatory,responses
R6137	T7954	T7957	advmod	how,activated
R6138	T7955	T7957	nsubjpass	NFκB,activated
R6139	T7956	T7957	auxpass	is,activated
R6140	T7957	T7953	pcomp	activated,about
R6141	T7790	T7792	nsubjpass	responses,activated
R6142	T7958	T7957	prep	in,activated
R6143	T7959	T7960	det	the,brain
R6144	T7960	T7958	pobj	brain,in
R6145	T7791	T7792	auxpass	is,activated
R6146	T7792	T7792	ROOT	activated,activated
R6147	T7793	T7792	cc	and,activated
R6148	T7794	T7792	conj	regulated,activated
R6149	T7795	T7794	prep	in,regulated
R6150	T7961	T7964	csubj	subjected,is
R6151	T7962	T7961	prep	to,subjected
R6152	T7963	T7962	pobj	ICH,to
R6153	T7796	T7798	det	the,tissue
R6154	T7964	T7964	ROOT	is,is
R6155	T7965	T7964	acomp	critical,is
R6156	T7797	T7798	compound	brain,tissue
R6157	T7966	T7965	prep	for,critical
R6158	T7967	T7966	pcomp	seeking,for
R6159	T7968	T7971	det	a,method
R6160	T7969	T7971	amod	new,method
R6161	T7798	T7795	pobj	tissue,in
R6162	T7970	T7971	amod	neuroprotective,method
R6163	T7971	T7967	dobj	method,seeking
R6164	T7972	T7971	prep	for,method
R6165	T7799	T7801	mark	after,is
R6166	T7973	T7972	pobj	ICH,for
R6167	T7974	T7964	punct	.,is
R6168	T7975	T7976	amod	Toll-like,receptors
R6169	T7800	T7801	nsubj	ICH,is
R6170	T7976	T7980	nsubj	receptors,are
R6171	T7977	T7976	punct	(,receptors
R6172	T7978	T7976	appos	TLRs,receptors
R6173	T7979	T7976	punct	),receptors
R6174	T7980	T7980	ROOT	are,are
R6175	T7801	T7794	advcl	is,regulated
R6176	T7802	T7801	acomp	unclear,is
R6177	T7981	T7982	det	a,family
R6178	T7982	T7980	attr	family,are
R6179	T7803	T7792	punct	.,activated
R6180	T7983	T7982	prep	of,family
R6181	T7984	T7986	nmod	signal,molecules
R6182	T7985	T7986	compound	transduction,molecules
R6183	T7804	T7805	amod	Transcription,factor
R6184	T7986	T7983	pobj	molecules,of
R6185	T7987	T7982	cc	and,family
R6186	T7988	T7980	conj	play,are
R6187	T7805	T7811	nsubj	factor,is
R6188	T7989	T7991	det	a,role
R6189	T7806	T7807	amod	nuclear,factor-kappa-B
R6190	T7990	T7991	amod	critical,role
R6191	T7991	T7988	dobj	role,play
R6192	T7992	T7988	prep	in,play
R6193	T7993	T7994	det	the,induction
R6194	T8058	T8049	conj	],diseases
R6195	T7994	T7992	pobj	induction,in
R6196	T7995	T7994	prep	of,induction
R6197	T7996	T7999	amod	innate,immunity
R6198	T7997	T7996	cc	and,innate
R6199	T8059	T8029	punct	.,reported
R6200	T7998	T7996	conj	adaptive,innate
R6201	T7999	T8000	compound	immunity,[
R6202	T8000	T7995	pobj	[,of
R6203	T8001	T8000	nummod	4,[
R6204	T8002	T7994	appos	],induction
R6205	T8003	T7980	punct	.,are
R6206	T8060	T8063	mark	Although,indicated
R6207	T8004	T8004	ROOT	TLR-mediated,TLR-mediated
R6208	T8005	T8004	advcl	signaling,TLR-mediated
R6209	T8006	T8008	nsubj	pathways,stimulate
R6210	T8061	T8062	amod	previous,reports
R6211	T8007	T8008	advmod	mainly,stimulate
R6212	T8008	T8005	ccomp	stimulate,signaling
R6213	T8009	T8010	det	the,activation
R6214	T8062	T8063	nsubj	reports,indicated
R6215	T8010	T8008	dobj	activation,stimulate
R6216	T8011	T8010	prep	of,activation
R6217	T8012	T8013	compound	NFκB,[
R6218	T8063	T8096	advcl	indicated,directed
R6219	T8013	T8011	pobj	[,of
R6220	T8014	T8016	quantmod	12,13
R6221	T8015	T8016	punct	",",13
R6222	T8016	T8017	nummod	13,]
R6223	T8017	T8013	appos	],[
R6224	T8018	T8005	punct	.,signaling
R6225	T8064	T8070	mark	that,attributed
R6226	T8019	T8025	npadvmod	TLR4,recognized
R6227	T8020	T8019	punct	",",TLR4
R6228	T8065	T8066	det	the,activation
R6229	T8066	T8070	nsubjpass	activation,attributed
R6230	T8021	T8024	det	the,TLR
R6231	T8022	T8024	amod	first,TLR
R6232	T8067	T8066	prep	of,activation
R6233	T8023	T8024	amod	mammalian,TLR
R6234	T8024	T8025	nsubj	TLR,recognized
R6235	T8025	T8029	csubjpass	recognized,reported
R6236	T8068	T8067	pobj	NFκB,of
R6237	T8026	T8025	punct	",",recognized
R6238	T8027	T8029	aux	has,reported
R6239	T8028	T8029	auxpass	been,reported
R6240	T8029	T8029	ROOT	reported,reported
R6241	T8030	T8032	aux	to,involved
R6242	T8069	T8070	auxpass	was,attributed
R6243	T8031	T8032	auxpass	be,involved
R6244	T8032	T8029	xcomp	involved,reported
R6245	T8033	T8032	prep	in,involved
R6246	T8070	T8063	ccomp	attributed,indicated
R6247	T8034	T8036	amod	several,nervous
R6248	T8035	T8036	amod	central,nervous
R6249	T8036	T8033	pobj	nervous,in
R6250	T8071	T8070	prep	to,attributed
R6251	T8037	T8036	punct	(,nervous
R6252	T8038	T8040	nmod	CNS,system
R6253	T8039	T8040	punct	),system
R6254	T8040	T8041	compound	system,diseases
R6255	T8072	T8074	det	the,stress
R6256	T8041	T8036	appos	diseases,nervous
R6257	T8042	T8041	punct	",",diseases
R6258	T8043	T8044	amod	such,as
R6259	T8073	T8074	amod	oxidative,stress
R6260	T8044	T8041	prep	as,diseases
R6261	T8045	T8049	amod	inflammatory,diseases
R6262	T8046	T8045	cc	or,inflammatory
R6263	T8047	T8045	conj	autoimmune,inflammatory
R6264	T8074	T8071	pobj	stress,to
R6265	T8048	T8045	conj	CNS,inflammatory
R6266	T8049	T8044	pobj	diseases,as
R6267	T8075	T8074	cc	or,stress
R6268	T8050	T8049	cc	and,diseases
R6269	T8051	T8058	amod	cerebral,]
R6270	T8052	T8058	dep	ischemic,]
R6271	T8053	T8054	compound	injury,[
R6272	T8054	T8052	appos	[,ischemic
R6273	T8055	T8054	nummod	7,[
R6274	T8056	T8058	punct	",",]
R6275	T8076	T8078	compound	glutamate,activation
R6276	T8057	T8058	nummod	8,]
R6277	T8077	T8078	compound	receptor,activation
R6278	T8078	T8074	conj	activation,stress
R6279	T8079	T8078	acl	induced,activation
R6280	T8080	T8079	agent	by,induced
R6281	T8155	T8156	det	These,changes
R6282	T8156	T8157	nsubj	changes,started
R6283	T8081	T8083	amod	red,cells
R6284	T8157	T8157	ROOT	started,started
R6285	T8158	T8159	advmod	as,early
R6286	T8159	T8157	advmod	early,started
R6287	T8082	T8083	compound	blood,cells
R6288	T8160	T8159	prep	as,early
R6289	T8161	T8162	nummod	6,hours
R6290	T8083	T8080	pobj	cells,by
R6291	T8162	T8163	npadvmod	hours,after
R6292	T8163	T8160	prep	after,as
R6293	T8164	T8166	det	the,insult
R6294	T8084	T8083	cc	and/or,cells
R6295	T8165	T8166	compound	ICH,insult
R6296	T8166	T8163	pobj	insult,after
R6297	T8167	T8157	cc	and,started
R6298	T8085	T8086	compound	plasma,constituents
R6299	T8168	T8157	conj	maintained,started
R6300	T8169	T8168	prep	at,maintained
R6301	T8170	T8172	det	a,level
R6302	T8171	T8172	amod	high,level
R6303	T8086	T8083	conj	constituents,cells
R6304	T8172	T8169	pobj	level,at
R6305	T8173	T8168	prep	for,maintained
R6306	T8087	T8089	nmod	[,]
R6307	T8174	T8175	nummod	7,days
R6308	T8175	T8173	pobj	days,for
R6309	T8176	T8168	advmod	afterward,maintained
R6310	T8088	T8089	nummod	17,]
R6311	T8177	T8157	punct	.,started
R6312	T8178	T8180	det	The,protein
R6313	T8179	T8180	nummod	TLR4,protein
R6314	T8089	T8083	appos	],cells
R6315	T8180	T8188	nsubjpass	protein,distributed
R6316	T8181	T8180	punct	",",protein
R6317	T8182	T8180	acl	detected,protein
R6318	T8090	T8096	punct	",",directed
R6319	T8183	T8182	agent	by,detected
R6320	T8184	T8183	pobj	immunohistochemistry,by
R6321	T8185	T8180	punct	",",protein
R6322	T8186	T8188	auxpass	was,distributed
R6323	T8187	T8188	advmod	consistently,distributed
R6324	T8188	T8188	ROOT	distributed,distributed
R6325	T8091	T8092	advmod	very,few
R6326	T8189	T8188	prep	in,distributed
R6327	T8190	T8191	amod	peri-hemorrhage,areas
R6328	T8191	T8189	pobj	areas,in
R6329	T8092	T8093	amod	few,studies
R6330	T8192	T8188	punct	",",distributed
R6331	T8193	T8194	det	the,hippocampus
R6332	T8093	T8096	nsubjpass	studies,directed
R6333	T8194	T8188	dep	hippocampus,distributed
R6334	T8195	T8194	punct	",",hippocampus
R6335	T8196	T8194	conj	cortex,hippocampus
R6336	T8197	T8196	punct	",",cortex
R6337	T8094	T8096	aux	have,directed
R6338	T8198	T8199	amod	thalamic,nuclei
R6339	T8199	T8196	conj	nuclei,cortex
R6340	T8200	T8199	punct	",",nuclei
R6341	T8095	T8096	auxpass	been,directed
R6342	T8201	T8199	cc	and,nuclei
R6343	T8202	T8205	det	some,tracts
R6344	T8096	T8096	ROOT	directed,directed
R6345	T8203	T8205	amod	white,tracts
R6346	T8204	T8205	compound	matter,tracts
R6347	T8205	T8199	conj	tracts,nuclei
R6348	T8097	T8098	aux	to,investigate
R6349	T8206	T8188	punct	.,distributed
R6350	T8207	T8208	det	These,data
R6351	T8208	T8209	nsubj	data,indicated
R6352	T8098	T8096	xcomp	investigate,directed
R6353	T8209	T8209	ROOT	indicated,indicated
R6354	T8210	T8217	mark	that,related
R6355	T8211	T8212	amod	increased,expression
R6356	T8212	T8217	nsubjpass	expression,related
R6357	T8099	T8100	det	the,role
R6358	T8213	T8212	prep	of,expression
R6359	T8214	T8213	pobj	TLR4,of
R6360	T8215	T8217	aux	may,related
R6361	T8100	T8098	dobj	role,investigate
R6362	T8216	T8217	auxpass	be,related
R6363	T8217	T8209	ccomp	related,indicated
R6364	T8101	T8100	cc	and,role
R6365	T8218	T8217	prep	to,related
R6366	T8102	T8103	det	the,relationship
R6367	T8219	T8220	det	the,triggering
R6368	T8220	T8218	pobj	triggering,to
R6369	T8221	T8220	prep	of,triggering
R6370	T8222	T8224	det	the,responses
R6371	T8223	T8224	amod	inflammatory,responses
R6372	T8224	T8221	pobj	responses,of
R6373	T8225	T8224	prep	in,responses
R6374	T8103	T8100	conj	relationship,role
R6375	T8226	T8228	det	the,tissue
R6376	T8227	T8228	compound	brain,tissue
R6377	T8104	T8103	prep	between,relationship
R6378	T8228	T8225	pobj	tissue,in
R6379	T8229	T8217	prep	after,related
R6380	T8230	T8229	pobj	ICH,after
R6381	T8105	T8106	compound	TLR4-mediated,NFκB
R6382	T8231	T8209	punct	.,indicated
R6383	T8232	T8233	amod	Recent,studies
R6384	T8233	T8234	nsubj	studies,demonstrated
R6385	T8106	T8104	pobj	NFκB,between
R6386	T8234	T8234	ROOT	demonstrated,demonstrated
R6387	T8235	T8237	mark	that,initiates
R6388	T8236	T8237	nsubj	ICH,initiates
R6389	T8237	T8234	ccomp	initiates,demonstrated
R6390	T8107	T8104	pobj	signaling,between
R6391	T8238	T8239	amod	inflammatory,responses
R6392	T8239	T8237	dobj	responses,initiates
R6393	T8240	T8239	punct	",",responses
R6394	T8108	T8107	cc	and,signaling
R6395	T8241	T8243	nsubjpass	which,associated
R6396	T8242	T8243	auxpass	are,associated
R6397	T8243	T8239	relcl	associated,responses
R6398	T8109	T8107	conj	ICH,signaling
R6399	T8244	T8243	prep	with,associated
R6400	T8245	T8246	amod	secondary,growth
R6401	T8246	T8244	pobj	growth,with
R6402	T8110	T8096	punct	.,directed
R6403	T8247	T8246	prep	of,growth
R6404	T8248	T8247	pobj	hemorrhage,of
R6405	T8111	T8117	prep	In,established
R6406	T8249	T8248	cc	and,hemorrhage
R6407	T8250	T8251	compound	cell,death
R6408	T8251	T8248	conj	death,hemorrhage
R6409	T8112	T8114	det	the,study
R6410	T8113	T8114	amod	present,study
R6411	T8114	T8111	pobj	study,In
R6412	T8252	T8254	nmod	[,]
R6413	T8253	T8254	nummod	18,]
R6414	T8115	T8117	punct	",",established
R6415	T8254	T8246	appos	],growth
R6416	T8255	T8234	punct	.,demonstrated
R6417	T8116	T8117	nsubj	we,established
R6418	T8256	T8259	nsubjpass	It,believed
R6419	T8257	T8259	auxpass	is,believed
R6420	T8258	T8259	advmod	now,believed
R6421	T8117	T8117	ROOT	established,established
R6422	T8259	T8259	ROOT	believed,believed
R6423	T8260	T8263	mark	that,activates
R6424	T8261	T8262	amod	TLR4-mediated-NFκB,pathway
R6425	T8262	T8263	nsubj	pathway,activates
R6426	T8263	T8259	ccomp	activates,believed
R6427	T8264	T8263	cc	and,activates
R6428	T8265	T8263	conj	regulates,activates
R6429	T8118	T8120	det	the,model
R6430	T8266	T8269	amod	immunological,responses
R6431	T8267	T8266	cc	and,immunological
R6432	T8268	T8266	conj	inflammatory,immunological
R6433	T8269	T8265	dobj	responses,regulates
R6434	T8119	T8120	compound	rat,model
R6435	T8270	T8259	punct	.,believed
R6436	T8271	T8272	aux	To,investigate
R6437	T8120	T8117	dobj	model,established
R6438	T8272	T8292	advcl	investigate,evaluated
R6439	T8273	T8274	det	the,mechanisms
R6440	T8274	T8272	dobj	mechanisms,investigate
R6441	T8275	T8274	acl	underlying,mechanisms
R6442	T8121	T8120	prep	of,model
R6443	T8276	T8279	det	the,responses
R6444	T8122	T8123	amod	experimental,ICH
R6445	T8277	T8279	amod	increased,responses
R6446	T8278	T8279	amod	inflammatory,responses
R6447	T8279	T8275	dobj	responses,underlying
R6448	T8280	T8279	prep	in,responses
R6449	T8281	T8282	det	the,brain
R6450	T8123	T8121	pobj	ICH,of
R6451	T8282	T8280	pobj	brain,in
R6452	T8283	T8292	mark	after,evaluated
R6453	T8284	T8292	nsubj	ICH,evaluated
R6454	T8124	T8117	cc	and,established
R6455	T8285	T8292	punct	",",evaluated
R6456	T8286	T8292	prep	in,evaluated
R6457	T8287	T8289	det	the,study
R6458	T8125	T8117	conj	detected,established
R6459	T8288	T8289	amod	present,study
R6460	T8289	T8286	pobj	study,in
R6461	T8290	T8292	punct	",",evaluated
R6462	T8126	T8128	det	the,mRNA
R6463	T8291	T8292	nsubj	we,evaluated
R6464	T8292	T8292	ROOT	evaluated,evaluated
R6465	T8293	T8294	det	the,activation
R6466	T8294	T8292	dobj	activation,evaluated
R6467	T8127	T8128	nummod	TLR4,mRNA
R6468	T8295	T8294	prep	of,activation
R6469	T8296	T8297	compound	TLR4-mediated,NFκB
R6470	T8128	T8125	dobj	mRNA,detected
R6471	T8129	T8128	cc	and,mRNA
R6472	T8297	T8295	pobj	NFκB,of
R6473	T8298	T8294	acl	signaling,activation
R6474	T8299	T8292	prep	by,evaluated
R6475	T8300	T8299	pcomp	detecting,by
R6476	T8301	T8302	det	the,p-IκB
R6477	T8302	T8300	dobj	p-IκB,detecting
R6478	T8130	T8128	conj	protein,mRNA
R6479	T8303	T8302	cc	and,p-IκB
R6480	T8304	T8305	det	the,activity
R6481	T8305	T8302	conj	activity,p-IκB
R6482	T8131	T8117	punct	.,established
R6483	T8306	T8305	prep	of,activity
R6484	T8307	T8306	pobj	NFκB,of
R6485	T8132	T8133	poss	Our,data
R6486	T8308	T8305	prep	in,activity
R6487	T8309	T8310	amod	hemorrhagic,brains
R6488	T8310	T8308	pobj	brains,in
R6489	T8133	T8134	nsubj	data,showed
R6490	T8311	T8292	punct	.,evaluated
R6491	T8312	T8313	nsubj	NFκB,is
R6492	T8134	T8134	ROOT	showed,showed
R6493	T8313	T8313	ROOT	is,is
R6494	T8314	T8317	det	an,factor
R6495	T8315	T8317	amod	important,factor
R6496	T8135	T8136	det	that,transcription
R6497	T8316	T8317	compound	transcription,factor
R6498	T8317	T8313	attr	factor,is
R6499	T8136	T8134	dobj	transcription,showed
R6500	T8318	T8317	amod	downstream,factor
R6501	T8319	T8318	prep	in,downstream
R6502	T8320	T8323	det	the,pathway
R6503	T8321	T8323	amod	TLR4-mediated,pathway
R6504	T8137	T8136	prep	of,transcription
R6505	T8322	T8323	amod	signaling,pathway
R6506	T8323	T8319	pobj	pathway,in
R6507	T8138	T8137	pobj	TLR4,of
R6508	T8324	T8313	punct	.,is
R6509	T8325	T8328	nsubj	Activation,stimulates
R6510	T8326	T8325	prep	of,Activation
R6511	T8139	T8141	advmod	as,as
R6512	T8327	T8328	nummod	TLR4,stimulates
R6513	T8328	T8328	ROOT	stimulates,stimulates
R6514	T8329	T8330	compound	IκBα,phosphorylation
R6515	T8330	T8328	dobj	phosphorylation,stimulates
R6516	T8140	T8141	advmod	well,as
R6517	T8331	T8330	cc	and,phosphorylation
R6518	T8332	T8330	conj	degradation,phosphorylation
R6519	T8333	T8330	punct	",",phosphorylation
R6520	T8141	T8136	cc	as,transcription
R6521	T8334	T8328	advcl	resulting,stimulates
R6522	T8335	T8334	prep	in,resulting
R6523	T8336	T8337	amod	nuclear,translocation
R6524	T8337	T8335	pobj	translocation,in
R6525	T8338	T8337	prep	of,translocation
R6526	T8339	T8338	pobj	NFκB,of
R6527	T8340	T8339	punct	",",NFκB
R6528	T8142	T8143	det	the,expression
R6529	T8341	T8342	nsubj	which,initiates
R6530	T8342	T8339	relcl	initiates,NFκB
R6531	T8343	T8342	dobj	transcription,initiates
R6532	T8143	T8136	conj	expression,transcription
R6533	T8344	T8343	prep	of,transcription
R6534	T8345	T8344	pobj	genes,of
R6535	T8346	T8345	acl	associated,genes
R6536	T8144	T8143	prep	of,expression
R6537	T8347	T8346	prep	with,associated
R6538	T8348	T8350	amod	innate,responses
R6539	T8145	T8146	nummod	TLR4,protein
R6540	T8146	T8144	pobj	protein,of
R6541	T8147	T8150	mark	after,elevated
R6542	T8148	T8150	nsubj	ICH,elevated
R6543	T8349	T8350	amod	immune,responses
R6544	T8350	T8347	pobj	responses,with
R6545	T8149	T8150	advmod	significantly,elevated
R6546	T8351	T8350	cc	and,responses
R6547	T8352	T8353	compound	inflammation,[
R6548	T8353	T8350	conj	[,responses
R6549	T8150	T8136	acl	elevated,transcription
R6550	T8354	T8353	nummod	5,[
R6551	T8355	T8356	punct	",",6
R6552	T8151	T8150	prep	in,elevated
R6553	T8356	T8357	nummod	6,]
R6554	T8357	T8353	appos	],[
R6555	T8358	T8328	punct	.,stimulates
R6556	T8152	T8153	compound	brain,tissue
R6557	T8359	T8360	nsubj	We,observed
R6558	T8360	T8360	ROOT	observed,observed
R6559	T8361	T8375	mark	that,increased
R6560	T8362	T8363	det	the,levels
R6561	T8153	T8151	pobj	tissue,in
R6562	T8363	T8375	nsubjpass	levels,increased
R6563	T8364	T8363	prep	of,levels
R6564	T8365	T8364	pobj	phosphorylation,of
R6565	T8154	T8134	punct	.,showed
R6566	T8366	T8365	prep	of,phosphorylation
R6567	T8367	T8366	pobj	IκB,of
R6568	T8368	T8365	cc	and,phosphorylation
R6569	T8446	T8447	amod	microbial,components
R6570	T8369	T8370	det	the,activity
R6571	T8370	T8365	conj	activity,phosphorylation
R6572	T8371	T8370	prep	of,activity
R6573	T8372	T8371	pobj	NFκB,of
R6574	T8373	T8375	auxpass	were,increased
R6575	T8374	T8375	advmod	significantly,increased
R6576	T8375	T8360	ccomp	increased,observed
R6577	T8447	T8445	pobj	components,of
R6578	T8448	T8456	nsubj	[,recognize
R6579	T8376	T8375	prep	in,increased
R6580	T8377	T8378	compound	brain,tissue
R6581	T8378	T8376	pobj	tissue,in
R6582	T8449	T8448	nummod	19,[
R6583	T8379	T8375	prep	after,increased
R6584	T8380	T8379	pobj	ICH,after
R6585	T8381	T8360	punct	.,observed
R6586	T8450	T8448	punct	",",[
R6587	T8382	T8384	det	The,profile
R6588	T8383	T8384	amod	temporal,profile
R6589	T8451	T8452	nummod	20,]
R6590	T8384	T8395	nsubj	profile,was
R6591	T8385	T8384	prep	of,profile
R6592	T8386	T8387	det	the,expression
R6593	T8452	T8448	appos	],[
R6594	T8453	T8452	cc	and,]
R6595	T8454	T8456	aux	can,recognize
R6596	T8387	T8385	pobj	expression,of
R6597	T8455	T8456	advmod	also,recognize
R6598	T8388	T8387	prep	of,expression
R6599	T8389	T8388	pobj	p-IκB,of
R6600	T8390	T8387	cc	and,expression
R6601	T8391	T8392	det	the,activation
R6602	T8392	T8395	nsubj	activation,was
R6603	T8456	T8456	ROOT	recognize,recognize
R6604	T8393	T8392	prep	of,activation
R6605	T8394	T8393	pobj	NFκB,of
R6606	T8395	T8395	ROOT	was,was
R6607	T8396	T8395	acomp	similar,was
R6608	T8457	T8458	amod	endogenous,molecules
R6609	T8397	T8396	prep	to,similar
R6610	T8398	T8397	pobj	that,to
R6611	T8399	T8398	prep	of,that
R6612	T8458	T8456	dobj	molecules,recognize
R6613	T8400	T8401	det	the,expression
R6614	T8401	T8399	pobj	expression,of
R6615	T8402	T8401	prep	of,expression
R6616	T8459	T8460	amod	such,as
R6617	T8403	T8402	pobj	TLR4,of
R6618	T8404	T8395	punct	.,was
R6619	T8405	T8406	poss	Our,data
R6620	T8460	T8458	prep	as,molecules
R6621	T8406	T8407	nsubj	data,suggest
R6622	T8407	T8407	ROOT	suggest,suggest
R6623	T8408	T8410	mark	that,stimulates
R6624	T8409	T8410	nsubj	ICH,stimulates
R6625	T8410	T8407	ccomp	stimulates,suggest
R6626	T8411	T8410	dobj	activation,stimulates
R6627	T8412	T8411	prep	of,activation
R6628	T8461	T8463	det	the,products
R6629	T8413	T8417	det	the,pathway
R6630	T8414	T8415	nummod	TLR4/NF,κB
R6631	T8415	T8417	nmod	κB,pathway
R6632	T8462	T8463	compound	degradation,products
R6633	T8416	T8417	amod	signaling,pathway
R6634	T8417	T8412	pobj	pathway,of
R6635	T8418	T8417	punct	",",pathway
R6636	T8419	T8420	nsubj	which,is
R6637	T8463	T8460	pobj	products,as
R6638	T8420	T8417	relcl	is,pathway
R6639	T8421	T8420	acomp	consistent,is
R6640	T8422	T8421	prep	with,consistent
R6641	T8464	T8463	prep	of,products
R6642	T8423	T8424	amod	previous,reports
R6643	T8424	T8422	pobj	reports,with
R6644	T8425	T8430	mark	that,regulated
R6645	T8426	T8430	nsubjpass	activation,regulated
R6646	T8465	T8464	pobj	macromolecules,of
R6647	T8427	T8426	prep	of,activation
R6648	T8428	T8427	pobj	NFκB,of
R6649	T8429	T8430	auxpass	is,regulated
R6650	T8466	T8463	punct	",",products
R6651	T8430	T8424	acl	regulated,reports
R6652	T8431	T8430	prep	through,regulated
R6653	T8432	T8435	det	the,pathway
R6654	T8467	T8463	conj	products,products
R6655	T8433	T8435	amod	TLR4-mediated,pathway
R6656	T8434	T8435	amod	signaling,pathway
R6657	T8435	T8431	pobj	pathway,through
R6658	T8468	T8463	prep	of,products
R6659	T8436	T8407	punct	.,suggest
R6660	T8437	T8438	nsubj	TLR4,plays
R6661	T8469	T8470	amod	proteolytic,cascades
R6662	T8438	T8438	ROOT	plays,plays
R6663	T8439	T8441	det	an,role
R6664	T8440	T8441	amod	important,role
R6665	T8441	T8438	dobj	role,plays
R6666	T8470	T8468	pobj	cascades,of
R6667	T8442	T8441	prep	in,role
R6668	T8443	T8444	det	the,recognition
R6669	T8444	T8442	pobj	recognition,in
R6670	T8471	T8470	punct	",",cascades
R6671	T8445	T8444	prep	of,recognition
R6672	T8472	T8473	amod	intracellular,components
R6673	T8473	T8463	conj	components,products
R6674	T8474	T8473	prep	of,components
R6675	T8543	T8544	compound	blood,cells
R6676	T8475	T8476	amod	ruptured,cells
R6677	T8544	T8542	pobj	cells,from
R6678	T8545	T8544	cc	and,cells
R6679	T8476	T8474	pobj	cells,of
R6680	T8546	T8544	conj	constituents,cells
R6681	T8547	T8544	prep	of,cells
R6682	T8548	T8549	compound	plasma,server
R6683	T8477	T8473	punct	",",components
R6684	T8549	T8547	pobj	server,of
R6685	T8550	T8541	prep	as,came
R6686	T8551	T8553	amod	endogenous,ligands
R6687	T8478	T8473	cc	and,components
R6688	T8552	T8553	nummod	TLR4,ligands
R6689	T8553	T8550	pobj	ligands,as
R6690	T8554	T8541	punct	",",came
R6691	T8479	T8473	conj	products,components
R6692	T8555	T8532	conj	activate,speculated
R6693	T8556	T8557	compound	TLR4-mediated,NFκB
R6694	T8557	T8558	nsubj	NFκB,signaling
R6695	T8480	T8479	prep	of,products
R6696	T8558	T8555	ccomp	signaling,activate
R6697	T8559	T8558	punct	",",signaling
R6698	T8481	T8480	pobj	genes,of
R6699	T8560	T8555	cc	and,activate
R6700	T8561	T8555	conj	initiate,activate
R6701	T8562	T8564	det	the,responses
R6702	T8482	T8484	nsubjpass	that,activated
R6703	T8563	T8564	amod	inflammatory,responses
R6704	T8564	T8561	dobj	responses,initiate
R6705	T8565	T8564	prep	in,responses
R6706	T8483	T8484	auxpass	are,activated
R6707	T8566	T8567	compound	IHC,brain
R6708	T8567	T8565	pobj	brain,in
R6709	T8568	T8532	punct	.,speculated
R6710	T8484	T8463	relcl	activated,products
R6711	T8569	T8583	advmod	However,determined
R6712	T8570	T8583	punct	",",determined
R6713	T8485	T8484	agent	by,activated
R6714	T8571	T8574	det	the,ligands
R6715	T8572	T8574	amod	specific,ligands
R6716	T8573	T8574	compound	endogenous,ligands
R6717	T8574	T8583	nsubjpass	ligands,determined
R6718	T8486	T8485	pobj	inflammation,by
R6719	T8575	T8574	prep	for,ligands
R6720	T8576	T8575	pobj	TLR4,for
R6721	T8577	T8576	prep	in,TLR4
R6722	T8487	T8456	punct	.,recognize
R6723	T8488	T8498	prep	For,enzymes
R6724	T8489	T8488	pobj	instance,For
R6725	T8578	T8579	amod	hemorrhagic,brain
R6726	T8579	T8577	pobj	brain,in
R6727	T8580	T8583	aux	have,determined
R6728	T8581	T8583	neg	not,determined
R6729	T8582	T8583	auxpass	been,determined
R6730	T8490	T8498	punct	",",enzymes
R6731	T8583	T8583	ROOT	determined,determined
R6732	T8584	T8583	cc	and,determined
R6733	T8585	T8583	conj	need,determined
R6734	T8491	T8498	nsubj	HSP70,enzymes
R6735	T8586	T8588	aux	to,identified
R6736	T8587	T8588	auxpass	be,identified
R6737	T8588	T8585	xcomp	identified,need
R6738	T8492	T8491	punct	",",HSP70
R6739	T8589	T8588	prep	through,identified
R6740	T8590	T8591	amod	further,research
R6741	T8591	T8589	pobj	research,through
R6742	T8592	T8583	punct	.,determined
R6743	T8493	T8491	conj	HSP32,HSP70
R6744	T8593	T8599	prep	In,demonstrated
R6745	T8594	T8593	pobj	conclusion,In
R6746	T8595	T8599	punct	",",demonstrated
R6747	T8494	T8493	punct	",",HSP32
R6748	T8596	T8598	det	the,study
R6749	T8597	T8598	amod	present,study
R6750	T8495	T8493	conj	HSP27,HSP32
R6751	T8598	T8599	nsubj	study,demonstrated
R6752	T8599	T8599	ROOT	demonstrated,demonstrated
R6753	T8600	T8602	det	the,profile
R6754	T8601	T8602	amod	temporal,profile
R6755	T8496	T8495	punct	",",HSP27
R6756	T8602	T8599	dobj	profile,demonstrated
R6757	T8603	T8602	prep	of,profile
R6758	T8604	T8605	det	the,activation
R6759	T8497	T8495	cc	and,HSP27
R6760	T8605	T8603	pobj	activation,of
R6761	T8606	T8605	prep	of,activation
R6762	T8498	T8498	ROOT	enzymes,enzymes
R6763	T8607	T8608	compound	TLR4-mediated,NFκB
R6764	T8608	T8606	pobj	NFκB,of
R6765	T8609	T8602	acl	signaling,profile
R6766	T8610	T8609	prep	in,signaling
R6767	T8499	T8498	acl	involved,enzymes
R6768	T8611	T8612	compound	brain,tissue
R6769	T8612	T8610	pobj	tissue,in
R6770	T8500	T8499	prep	in,involved
R6771	T8501	T8502	amod	oxidative,stress
R6772	T8613	T8612	prep	in,tissue
R6773	T8502	T8500	pobj	stress,in
R6774	T8614	T8616	det	a,model
R6775	T8615	T8616	compound	rat,model
R6776	T8616	T8613	pobj	model,in
R6777	T8617	T8616	prep	of,model
R6778	T8618	T8619	amod	experimental,ICH
R6779	T8619	T8617	pobj	ICH,of
R6780	T8503	T8504	auxpass	are,found
R6781	T8620	T8619	punct	",",ICH
R6782	T8621	T8622	nsubj	which,suggests
R6783	T8504	T8498	conj	found,enzymes
R6784	T8622	T8602	relcl	suggests,profile
R6785	T8623	T8627	mark	that,participates
R6786	T8624	T8625	compound	TLR4-mediated,NFκB
R6787	T8625	T8627	nsubj	NFκB,participates
R6788	T8505	T8507	aux	to,upregulated
R6789	T8626	T8625	acl	signaling,NFκB
R6790	T8627	T8622	ccomp	participates,suggests
R6791	T8506	T8507	auxpass	be,upregulated
R6792	T8628	T8627	prep	in,participates
R6793	T8629	T8630	det	the,pathogenesis
R6794	T8630	T8628	pobj	pathogenesis,in
R6795	T8631	T8630	prep	of,pathogenesis
R6796	T8507	T8504	xcomp	upregulated,found
R6797	T8632	T8631	pobj	ICH,of
R6798	T8633	T8632	punct	",",ICH
R6799	T8634	T8636	nsubj	which,be
R6800	T8508	T8507	prep	in,upregulated
R6801	T8635	T8636	aux	may,be
R6802	T8636	T8630	relcl	be,pathogenesis
R6803	T8637	T8639	det	a,target
R6804	T8509	T8510	det	the,brain
R6805	T8638	T8639	amod	therapeutic,target
R6806	T8639	T8636	attr	target,be
R6807	T8510	T8508	pobj	brain,in
R6808	T8511	T8507	prep	after,upregulated
R6809	T8640	T8639	prep	for,target
R6810	T8512	T8511	pobj	ICH,after
R6811	T8641	T8642	det	the,prevention
R6812	T8642	T8640	pobj	prevention,for
R6813	T8643	T8642	prep	of,prevention
R6814	T8513	T8512	punct	",",ICH
R6815	T8644	T8646	amod	ICH-induced,damage
R6816	T8645	T8646	compound	brain,damage
R6817	T8646	T8643	pobj	damage,of
R6818	T8514	T8517	nsubjpass	which,produced
R6819	T8647	T8599	punct	.,demonstrated
R6820	T8515	T8517	aux	may,produced
R6821	T8516	T8517	auxpass	be,produced
R6822	T8517	T8512	relcl	produced,ICH
R6823	T8518	T8517	agent	by,produced
R6824	T8519	T8521	amod	injured,cells
R6825	T8520	T8521	amod	neuronal,cells
R6826	T8521	T8518	pobj	cells,by
R6827	T8522	T8521	cc	or,cells
R6828	T8523	T8524	compound	blood,cells
R6829	T8524	T8521	conj	cells,cells
R6830	T8525	T8527	nmod	[,]
R6831	T8526	T8527	nummod	21,]
R6832	T8527	T8521	appos	],cells
R6833	T8528	T8498	punct	.,enzymes
R6834	T8529	T8532	nsubjpass	It,speculated
R6835	T8530	T8532	aux	may,speculated
R6836	T8531	T8532	auxpass	be,speculated
R6837	T8532	T8532	ROOT	speculated,speculated
R6838	T8533	T8541	mark	that,came
R6839	T8534	T8535	det	these,molecules
R6840	T8535	T8541	nsubj	molecules,came
R6841	T8536	T8535	acl	produced,molecules
R6842	T8537	T8536	prep	in,produced
R6843	T8538	T8539	amod	damaged,brain
R6844	T8539	T8537	pobj	brain,in
R6845	T8540	T8536	cc	or,produced
R6848	T8541	T8532	ccomp	came,speculated
R6850	T8542	T8541	prep	from,came
R5879	T7679	T7681	compound	brain,damage
R5938	T7807	T7811	nsubj	factor-kappa-B,is
R5940	T7808	T7807	punct	(,factor-kappa-B
R5942	T7809	T7807	appos	NFκB,factor-kappa-B
R5943	T7810	T7807	punct	),factor-kappa-B
R5945	T7811	T7836	ccomp	is,plays
R5946	T7812	T7816	det	an,factor
R5947	T7813	T7816	amod	important,factor
R5949	T7814	T7815	amod	nuclear,transcription
R5950	T7815	T7816	compound	transcription,factor
R5951	T7816	T7811	attr	factor,is
R5953	T7817	T7816	punct	",",factor
R5954	T7818	T7819	nsubj	which,initiates
R5963	T7824	T7823	prep	with,associated

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T6498	6125-6129	Protein	denotes	NFκB
T6497	6111-6115	Protein	denotes	TLR4
T6496	6024-6028	Protein	denotes	NFκB
T6495	6010-6014	Protein	denotes	TLR4
T6494	5819-5823	Protein	denotes	TLR4
T6493	5704-5708	Protein	denotes	NFκB
T6492	5690-5694	Protein	denotes	TLR4
T6491	5667-5671	Protein	denotes	TLR4
T6490	5421-5432	Positive_regulation	denotes	upregulated
T6489	5421-5432	Positive_regulation	denotes	upregulated
T6488	5421-5432	Positive_regulation	denotes	upregulated
T6487	5357-5362	Protein	denotes	HSP27
T6486	5350-5355	Protein	denotes	HSP32
T6485	5343-5348	Protein	denotes	HSP70
T6484	5110-5119	Binding	denotes	recognize
T6483	5016-5020	Protein	denotes	TLR4
T6482	4834-4844	Positive_regulation	denotes	stimulates
T6481	4834-4844	Positive_regulation	denotes	stimulates
T6480	4961-4970	Regulation	denotes	regulated
T6479	4939-4949	Positive_regulation	denotes	activation
T6478	4845-4855	Positive_regulation	denotes	activation
T6477	4845-4855	Positive_regulation	denotes	activation
T6476	4983-4987	Protein	denotes	TLR4
T6475	4953-4957	Protein	denotes	NFκB
T6474	4868-4872	Protein	denotes	NFκB
T6473	4863-4867	Protein	denotes	TLR4
T6472	4830-4833	Protein	denotes	ICH
T6471	4788-4798	Gene_expression	denotes	expression
T6470	4742-4752	Positive_regulation	denotes	activation
T6469	4742-4752	Positive_regulation	denotes	activation
T6468	4714-4724	Gene_expression	denotes	expression
T6467	4802-4806	Protein	denotes	TLR4
T6466	4756-4760	Protein	denotes	NFκB
T6465	4728-4733	Protein	denotes	p-IκB
T6464	4649-4658	Positive_regulation	denotes	increased
T6463	4582-4597	Phosphorylation	denotes	phosphorylation
T6462	4625-4629	Protein	denotes	NFκB
T6461	4601-4604	Protein	denotes	IκB
T6460	4354-4364	Positive_regulation	denotes	stimulates
T6459	4354-4364	Positive_regulation	denotes	stimulates
T6458	4424-4437	Localization	denotes	translocation
T6457	4416-4423	Entity	denotes	nuclear
T6456	4390-4401	Protein_catabolism	denotes	degradation
T6455	4370-4385	Phosphorylation	denotes	phosphorylation
T6454	4335-4345	Positive_regulation	denotes	Activation
T6453	4441-4445	Protein	denotes	NFκB
T6452	4365-4369	Protein	denotes	IκBα
T6451	4349-4353	Protein	denotes	TLR4
T6450	4302-4306	Protein	denotes	TLR4
T6449	4242-4246	Protein	denotes	NFκB
T6448	4174-4183	Gene_expression	denotes	detecting
T6447	4174-4183	Gene_expression	denotes	detecting
T6446	4214-4218	Protein	denotes	NFκB
T6445	4188-4193	Protein	denotes	p-IκB
T6444	4156-4160	Protein	denotes	NFκB
T6443	4142-4146	Protein	denotes	TLR4
T6442	3908-3912	Protein	denotes	NFκB
T6441	3894-3898	Protein	denotes	TLR4
T6440	3598-3607	Positive_regulation	denotes	increased
T6439	3608-3618	Gene_expression	denotes	expression
T6438	3622-3626	Protein	denotes	TLR4
T6437	3462-3473	Localization	denotes	distributed
T6436	3397-3409	Protein	denotes	TLR4 protein
T6435	3251-3259	Positive_regulation	denotes	elevated
T6434	3251-3259	Positive_regulation	denotes	elevated
T6433	3200-3210	Gene_expression	denotes	expression
T6432	3163-3176	Transcription	denotes	transcription
T6431	3214-3218	Protein	denotes	TLR4
T6430	3180-3184	Protein	denotes	TLR4
T6429	3106-3114	Gene_expression	denotes	detected
T6428	3119-3128	Protein	denotes	TLR4 mRNA
T6427	2753-2763	Positive_regulation	denotes	activation
T6426	3026-3029	Protein	denotes	ICH
T6425	3007-3011	Protein	denotes	NFκB
T6424	2993-2997	Protein	denotes	TLR4
T6423	2814-2832	Protein	denotes	glutamate receptor
T6422	2767-2771	Protein	denotes	NFκB
T6421	2498-2502	Protein	denotes	TLR4
T6420	2307-2336	Protein	denotes	signal transduction molecules
T6419	2162-2171	Positive_regulation	denotes	activated
T6418	2154-2158	Protein	denotes	NFκB
T6417	1942-1952	Negative_regulation	denotes	Inhibition
T6416	1956-1960	Protein	denotes	NFκB
T6415	1811-1821	Positive_regulation	denotes	Activation
T6414	1825-1829	Protein	denotes	NFκB
T6413	1654-1664	Positive_regulation	denotes	activation
T6412	1735-1738	Protein	denotes	ICH
T6411	1649-1653	Protein	denotes	NFκB
T6410	1588-1592	Protein	denotes	NFκB
T6409	1405-1418	Transcription	denotes	transcription
T6408	1337-1341	Protein	denotes	NFκB
T6407	1313-1335	Protein	denotes	nuclear factor-kappa-B
T6406	1105-1120	Protein	denotes	immunoglobulins
R4675	T6408	T6409	themeOf	NFκB,transcription
R4676	T6411	T6413	themeOf	NFκB,activation
R4677	T6414	T6415	themeOf	NFκB,Activation
R4678	T6416	T6417	themeOf	NFκB,Inhibition
R4679	T6418	T6419	themeOf	NFκB,activated
R4680	T6422	T6427	themeOf	NFκB,activation
R4681	T6428	T6429	themeOf	TLR4 mRNA,detected
R4682	T6430	T6432	themeOf	TLR4,transcription
R4683	T6431	T6433	themeOf	TLR4,expression
R4684	T6432	T6434	themeOf	transcription,elevated
R4685	T6433	T6435	themeOf	expression,elevated
R4686	T6436	T6437	themeOf	TLR4 protein,distributed
R4687	T6438	T6439	themeOf	TLR4,expression
R4688	T6439	T6440	themeOf	expression,increased
R4689	T6445	T6447	themeOf	p-IκB,detecting
R4690	T6446	T6448	themeOf	NFκB,detecting
R4691	T6451	T6454	themeOf	TLR4,Activation
R4692	T6452	T6455	themeOf	IκBα,phosphorylation
R4693	T6452	T6456	themeOf	IκBα,degradation
R4694	T6453	T6458	themeOf	NFκB,translocation
R4695	T6454	T6459	causeOf	Activation,stimulates
R4696	T6454	T6460	causeOf	Activation,stimulates
R4697	T6455	T6459	themeOf	phosphorylation,stimulates
R4698	T6456	T6460	themeOf	degradation,stimulates
R4699	T6457	T6458	locationOf	nuclear,translocation
R4700	T6461	T6463	themeOf	IκB,phosphorylation
R4701	T6463	T6464	themeOf	phosphorylation,increased
R4702	T6465	T6468	themeOf	p-IκB,expression
R4703	T6466	T6469	themeOf	NFκB,activation
R4704	T6467	T6471	themeOf	TLR4,expression
R4705	T6468	T6470	themeOf	expression,activation
R4706	T6472	T6481	causeOf	ICH,stimulates
R4707	T6472	T6482	causeOf	ICH,stimulates
R4708	T6473	T6477	themeOf	TLR4,activation
R4709	T6474	T6478	themeOf	NFκB,activation
R4710	T6475	T6479	themeOf	NFκB,activation
R4711	T6477	T6481	themeOf	activation,stimulates
R4712	T6478	T6482	themeOf	activation,stimulates
R4713	T6479	T6480	themeOf	activation,regulated
R4714	T6483	T6484	themeOf	TLR4,recognize
R4715	T6485	T6488	themeOf	HSP70,upregulated
R4716	T6486	T6489	themeOf	HSP32,upregulated
R4717	T6487	T6490	themeOf	HSP27,upregulated

testone

Id	Subject	Object	Predicate	Lexical cue
T6097	5470-5478	Gene_expression	denotes	produced
T6096	4961-4970	Regulation	denotes	regulated
T6095	4788-4798	Gene_expression	denotes	expression
T6094	4714-4724	Gene_expression	denotes	expression
T6093	4649-4658	Positive_regulation	denotes	increased
T6092	4424-4437	Localization	denotes	translocation
T6091	4390-4401	Protein_catabolism	denotes	degradation
T6090	4370-4385	Phosphorylation	denotes	phosphorylation
T6089	4335-4345	Positive_regulation	denotes	Activation
T6088	3608-3618	Gene_expression	denotes	expression
T6087	3598-3607	Positive_regulation	denotes	increased
T6086	3251-3259	Positive_regulation	denotes	elevated
T6085	3200-3210	Gene_expression	denotes	expression
T6084	3163-3176	Transcription	denotes	transcription
T6083	2528-2538	Binding	denotes	recognized
T6082	2108-2116	Gene_expression	denotes	produced
T6081	834-843	Gene_expression	denotes	producing
T6080	6111-6115	Protein	denotes	TLR4
T6079	6010-6014	Protein	denotes	TLR4
T6078	5819-5823	Protein	denotes	TLR4
T6077	5690-5694	Protein	denotes	TLR4
T6076	5667-5671	Protein	denotes	TLR4
T6075	5357-5362	Protein	denotes	HSP27
T6074	5350-5355	Protein	denotes	HSP32
T6073	5343-5348	Protein	denotes	HSP70
T6072	5016-5020	Protein	denotes	TLR4
T6071	4983-4987	Protein	denotes	TLR4
T6070	4863-4867	Protein	denotes	TLR4
T6069	4802-4806	Protein	denotes	TLR4
T6068	4365-4369	Protein	denotes	IκBα
T6067	4349-4353	Protein	denotes	TLR4
T6066	4302-4306	Protein	denotes	TLR4
T6065	4142-4146	Protein	denotes	TLR4
T6064	3894-3898	Protein	denotes	TLR4
T6063	3622-3626	Protein	denotes	TLR4
T6062	3397-3401	Protein	denotes	TLR4
T6061	3214-3218	Protein	denotes	TLR4
T6060	3180-3184	Protein	denotes	TLR4
T6059	3119-3123	Protein	denotes	TLR4
T6058	2993-2997	Protein	denotes	TLR4
T6057	2498-2502	Protein	denotes	TLR4
R4608	T6057	T6083	themeOf	TLR4,recognized
R4609	T6060	T6084	themeOf	TLR4,transcription
R4610	T6061	T6085	themeOf	TLR4,expression
R4611	T6063	T6088	themeOf	TLR4,expression
R4612	T6067	T6089	themeOf	TLR4,Activation
R4613	T6067	T6091	themeOf	TLR4,degradation
R4614	T6067	T6092	themeOf	TLR4,translocation
R4615	T6068	T6092	themeOf	IκBα,translocation
R4616	T6068	T6091	themeOf	IκBα,degradation
R4617	T6068	T6090	themeOf	IκBα,phosphorylation
R4618	T6069	T6095	themeOf	TLR4,expression
R4619	T6073	T6097	themeOf	HSP70,produced
R4620	T6074	T6097	themeOf	HSP32,produced
R4621	T6075	T6097	themeOf	HSP27,produced
R4622	T6085	T6086	themeOf	expression,elevated
R4623	T6088	T6087	themeOf	expression,increased

test3

Id	Subject	Object	Predicate	Lexical cue
T6159	6111-6115	Protein	denotes	TLR4
T6158	6010-6014	Protein	denotes	TLR4
T6157	5819-5823	Protein	denotes	TLR4
T6156	5690-5694	Protein	denotes	TLR4
T6155	5667-5671	Protein	denotes	TLR4
T6154	5470-5478	Gene_expression	denotes	produced
T6153	5357-5362	Protein	denotes	HSP27
T6152	5350-5355	Protein	denotes	HSP32
T6151	5343-5348	Protein	denotes	HSP70
T6150	5016-5020	Protein	denotes	TLR4
T6149	4983-4987	Protein	denotes	TLR4
T6148	4863-4867	Protein	denotes	TLR4
T6147	4802-4806	Protein	denotes	TLR4
T6146	4788-4798	Gene_expression	denotes	expression
T6145	4582-4597	Phosphorylation	denotes	phosphorylation
T6144	4424-4437	Localization	denotes	translocation
T6143	4416-4423	Entity	denotes	nuclear
T6142	4403-4412	Positive_regulation	denotes	resulting
T6141	4390-4401	Protein_catabolism	denotes	degradation
T6140	4370-4385	Phosphorylation	denotes	phosphorylation
T6139	4365-4369	Protein	denotes	IκBα
T6138	4349-4353	Protein	denotes	TLR4
T6137	4335-4345	Positive_regulation	denotes	Activation
T6136	4302-4306	Protein	denotes	TLR4
T6135	4142-4146	Protein	denotes	TLR4
T6134	3894-3898	Protein	denotes	TLR4
T6133	3622-3626	Protein	denotes	TLR4
T6132	3608-3618	Gene_expression	denotes	expression
T6131	3598-3607	Positive_regulation	denotes	increased
T6130	3397-3401	Protein	denotes	TLR4
T6129	3214-3218	Protein	denotes	TLR4
T6128	3200-3210	Gene_expression	denotes	expression
T6127	3180-3184	Protein	denotes	TLR4
T6126	3163-3176	Transcription	denotes	transcription
T6125	3119-3123	Protein	denotes	TLR4
T6124	3106-3114	Gene_expression	denotes	detected
T6123	2993-2997	Protein	denotes	TLR4
T6122	2498-2502	Protein	denotes	TLR4
T6121	6111-6115	Protein	denotes	TLR4
T6120	6010-6014	Protein	denotes	TLR4
T6119	5819-5823	Protein	denotes	TLR4
T6118	5690-5694	Protein	denotes	TLR4
T6117	5667-5671	Protein	denotes	TLR4
T6116	5357-5362	Protein	denotes	HSP27
T6115	5350-5355	Protein	denotes	HSP32
T6114	5343-5348	Protein	denotes	HSP70
T6113	5016-5020	Protein	denotes	TLR4
T6112	4983-4987	Protein	denotes	TLR4
T6111	4863-4867	Protein	denotes	TLR4
T6110	4802-4806	Protein	denotes	TLR4
T6109	4365-4369	Protein	denotes	IκBα
T6108	4349-4353	Protein	denotes	TLR4
T6107	4302-4306	Protein	denotes	TLR4
T6106	4142-4146	Protein	denotes	TLR4
T6105	3894-3898	Protein	denotes	TLR4
T6104	3622-3626	Protein	denotes	TLR4
T6103	3397-3401	Protein	denotes	TLR4
T6102	3214-3218	Protein	denotes	TLR4
T6101	3180-3184	Protein	denotes	TLR4
T6100	3119-3123	Protein	denotes	TLR4
T6099	2993-2997	Protein	denotes	TLR4
T6098	2498-2502	Protein	denotes	TLR4
R4624	T6125	T6124	themeOf	TLR4,detected
R4625	T6127	T6126	themeOf	TLR4,transcription
R4626	T6129	T6128	themeOf	TLR4,expression
R4627	T6132	T6131	themeOf	expression,increased
R4628	T6133	T6132	themeOf	TLR4,expression
R4629	T6137	T6142	causeOf	Activation,resulting
R4630	T6138	T6144	themeOf	TLR4,translocation
R4631	T6139	T6144	themeOf	IκBα,translocation
R4632	T6139	T6141	themeOf	IκBα,degradation
R4633	T6139	T6140	themeOf	IκBα,phosphorylation
R4634	T6140	T6137	themeOf	phosphorylation,Activation
R4635	T6143	T6144	locationOf	nuclear,translocation
R4636	T6144	T6142	themeOf	translocation,resulting
R4637	T6147	T6146	themeOf	TLR4,expression
R4638	T6151	T6154	themeOf	HSP70,produced
R4639	T6152	T6154	themeOf	HSP32,produced
R4640	T6153	T6154	themeOf	HSP27,produced

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