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2_test

Id Subject Object Predicate Lexical cue
20150961-11898581-67933695 1643-1644 11898581 denotes 1
20150961-15845210-67933696 1866-1867 15845210 denotes 3
20150961-10963608-67933697 2222-2223 10963608 denotes 4
20150961-10679407-67933698 2380-2381 10679407 denotes 5
20150961-11477402-67933699 2383-2384 11477402 denotes 6
20150961-10679407-67933700 2688-2689 10679407 denotes 5
20150961-11477402-67933701 2691-2692 11477402 denotes 6
20150961-17884182-67933702 2900-2901 17884182 denotes 8
20150961-17884182-67933703 3130-3131 17884182 denotes 8
20150961-17372179-67933704 3133-3134 17372179 denotes 9
20150961-17884182-67933705 4495-4496 17884182 denotes 8
20150961-17884182-67933706 7431-7432 17884182 denotes 8
20150961-17884182-67933707 9035-9036 17884182 denotes 8
20150961-11898581-67933708 12210-12211 11898581 denotes 1
20150961-16680558-67933709 12373-12375 16680558 denotes 10
20150961-15861332-67933710 12891-12893 15861332 denotes 11
20150961-12356687-67933711 13504-13506 12356687 denotes 12
20150961-11896392-67933712 13508-13510 11896392 denotes 13
20150961-19326286-67933713 13669-13671 19326286 denotes 14
20150961-17250675-67933714 13831-13833 17250675 denotes 15
20150961-10548686-67933715 13962-13964 10548686 denotes 16
20150961-17261732-67933716 14150-14152 17261732 denotes 17
20150961-10963608-67933717 14437-14438 10963608 denotes 4
20150961-12356687-67933718 14514-14516 12356687 denotes 12
20150961-11896392-67933719 14518-14520 11896392 denotes 13
20150961-17884182-67933720 14729-14730 17884182 denotes 8
20150961-17261732-67933721 14924-14926 17261732 denotes 17
20150961-17971790-67933722 15890-15892 17971790 denotes 18
20150961-10679407-67933723 16569-16570 10679407 denotes 5
20150961-11477402-67933724 16572-16573 11477402 denotes 6
20150961-12906258-67933725 17118-17120 12906258 denotes 20
20150961-18705926-67933726 17546-17548 18705926 denotes 21

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T155 0-10 NN denotes Activation
T156 11-13 IN denotes of
T157 14-27 JJ denotes TLR4-Mediated
T158 28-32 NN denotes NFκB
T159 33-42 NN denotes Signaling
T160 43-45 IN denotes in
T161 46-57 NNP denotes Hemorrhagic
T162 58-63 NNP denotes Brain
T163 64-66 IN denotes in
T164 67-71 NN denotes Rats
T7536 18032-18034 IN denotes of
T7535 18021-18031 NN denotes activation
T7534 18017-18020 DT denotes the
T7533 18014-18016 IN denotes of
T7532 18006-18013 NN denotes profile
T7531 17997-18005 JJ denotes temporal
T7530 17993-17996 DT denotes the
T7529 17980-17992 VB denotes demonstrated
T7528 17974-17979 NN denotes study
T7527 17966-17973 JJ denotes present
T7526 17962-17965 DT denotes the
T7525 17960-17961 -COMMA- denotes ,
T7524 17950-17960 NN denotes conclusion
T7523 17947-17949 IN denotes In
T7522 17937-17945 NN denotes research
T7521 17929-17936 JJ denotes further
T7520 17921-17928 IN denotes through
T7519 17910-17920 VB denotes identified
T7518 17907-17909 VB denotes be
T7517 17904-17906 TO denotes to
T7516 17899-17903 VB denotes need
T7515 17895-17898 CC denotes and
T7514 17884-17894 VB denotes determined
T7513 17879-17883 VB denotes been
T7512 17875-17878 RB denotes not
T7511 17870-17874 VB denotes have
T7510 17864-17869 NN denotes brain
T7509 17852-17863 JJ denotes hemorrhagic
T7508 17849-17851 IN denotes in
T7507 17844-17848 NN denotes TLR4
T7506 17840-17843 IN denotes for
T7505 17832-17839 NN denotes ligands
T7504 17821-17831 JJ denotes endogenous
T7503 17812-17820 JJ denotes specific
T7502 17808-17811 DT denotes the
T7501 17806-17807 -COMMA- denotes ,
T7500 17799-17806 RB denotes However
T7499 17792-17797 NN denotes brain
T7498 17788-17791 NN denotes IHC
T7497 17785-17787 IN denotes in
T7496 17775-17784 NN denotes responses
T7495 17762-17774 JJ denotes inflammatory
T7494 17758-17761 DT denotes the
T7493 17749-17757 VB denotes initiate
T7492 17745-17748 CC denotes and
T7491 17743-17744 -COMMA- denotes ,
T7490 17734-17743 NN denotes signaling
T7489 17729-17733 NN denotes NFκB
T7488 17715-17728 JJ denotes TLR4-mediated
T7487 17706-17714 VB denotes activate
T7486 17704-17705 -COMMA- denotes ,
T7485 17697-17704 NN denotes ligands
T7484 17692-17696 NN denotes TLR4
T7483 17681-17691 JJ denotes endogenous
T7482 17678-17680 IN denotes as
T7481 17671-17677 NN denotes server
T7480 17664-17670 NN denotes plasma
T7479 17661-17663 IN denotes of
T7478 17648-17660 NN denotes constituents
T7477 17644-17647 CC denotes and
T7476 17638-17643 NN denotes cells
T7475 17632-17637 NN denotes blood
T7474 17627-17631 IN denotes from
T7473 17622-17626 VB denotes came
T7472 17619-17621 CC denotes or
T7471 17613-17618 NN denotes brain
T7470 17605-17612 VB denotes damaged
T7469 17602-17604 IN denotes in
T7468 17593-17601 VB denotes produced
T7467 17583-17592 NN denotes molecules
T7466 17577-17582 DT denotes these
T7465 17572-17576 IN denotes that
T7464 17561-17571 VB denotes speculated
T7463 17558-17560 VB denotes be
T7462 17554-17557 MD denotes may
T7461 17551-17553 PRP denotes It
T7460 17548-17549 -RRB- denotes ]
T7459 17546-17548 CD denotes 21
T7458 17545-17546 -LRB- denotes [
T7457 17539-17544 NN denotes cells
T7456 17533-17538 NN denotes blood
T7455 17530-17532 CC denotes or
T7454 17524-17529 NN denotes cells
T7453 17515-17523 JJ denotes neuronal
T7452 17507-17514 VB denotes injured
T7451 17504-17506 IN denotes by
T7450 17495-17503 VB denotes produced
T7449 17492-17494 VB denotes be
T7448 17488-17491 MD denotes may
T7447 17482-17487 WDT denotes which
T7446 17480-17481 -COMMA- denotes ,
T7445 17477-17480 NN denotes ICH
T7444 17471-17476 IN denotes after
T7443 17465-17470 NN denotes brain
T7442 17461-17464 DT denotes the
T7441 17458-17460 IN denotes in
T7440 17446-17457 VB denotes upregulated
T7439 17443-17445 VB denotes be
T7438 17440-17442 TO denotes to
T7437 17434-17439 VB denotes found
T7436 17430-17433 VB denotes are
T7435 17423-17429 NN denotes stress
T7434 17413-17422 JJ denotes oxidative
T7433 17410-17412 IN denotes in
T7432 17401-17409 VB denotes involved
T7431 17393-17400 NN denotes enzymes
T7430 17389-17392 CC denotes and
T7429 17387-17388 -COMMA- denotes ,
T7428 17382-17387 NN denotes HSP27
T7427 17380-17381 -COMMA- denotes ,
T7426 17375-17380 NN denotes HSP32
T7425 17373-17374 -COMMA- denotes ,
T7424 17368-17373 NN denotes HSP70
T7423 17366-17367 -COMMA- denotes ,
T7422 17358-17366 NN denotes instance
T7421 17354-17357 IN denotes For
T7420 17340-17352 NN denotes inflammation
T7419 17337-17339 IN denotes by
T7418 17327-17336 VB denotes activated
T7417 17323-17326 VB denotes are
T7416 17318-17322 WDT denotes that
T7415 17312-17317 NN denotes genes
T7414 17309-17311 IN denotes of
T7413 17300-17308 NN denotes products
T7412 17296-17299 CC denotes and
T7411 17294-17295 -COMMA- denotes ,
T7410 17289-17294 NN denotes cells
T7409 17280-17288 JJ denotes ruptured
T7408 17277-17279 IN denotes of
T7407 17266-17276 NN denotes components
T7406 17252-17265 JJ denotes intracellular
T7405 17250-17251 -COMMA- denotes ,
T7404 17242-17250 NN denotes cascades
T7403 17230-17241 JJ denotes proteolytic
T7402 17227-17229 IN denotes of
T7401 17218-17226 NN denotes products
T7400 17216-17217 -COMMA- denotes ,
T7399 17202-17216 NN denotes macromolecules
T7398 17199-17201 IN denotes of
T7397 17190-17198 NN denotes products
T7396 17178-17189 NN denotes degradation
T7395 17174-17177 DT denotes the
T7394 17171-17173 IN denotes as
T7393 17166-17170 JJ denotes such
T7392 17156-17165 NN denotes molecules
T7391 17145-17155 JJ denotes endogenous
T7390 17135-17144 VB denotes recognize
T7389 17130-17134 RB denotes also
T7388 17126-17129 MD denotes can
T7387 17122-17125 CC denotes and
T7386 17120-17121 -RRB- denotes ]
T7385 17118-17120 CD denotes 20
T7384 17116-17117 -COMMA- denotes ,
T7383 17114-17116 CD denotes 19
T7382 17113-17114 -LRB- denotes [
T7381 17102-17112 NN denotes components
T7380 17092-17101 JJ denotes microbial
T7379 17089-17091 IN denotes of
T7378 17077-17088 NN denotes recognition
T7377 17073-17076 DT denotes the
T7376 17070-17072 IN denotes in
T7375 17065-17069 NN denotes role
T7374 17055-17064 JJ denotes important
T7373 17052-17054 DT denotes an
T7372 17046-17051 VB denotes plays
T7371 17041-17045 NN denotes TLR4
T7370 17032-17039 NN denotes pathway
T7369 17022-17031 NN denotes signaling
T7368 17008-17021 JJ denotes TLR4-mediated
T7367 17004-17007 DT denotes the
T7366 16996-17003 IN denotes through
T7365 16986-16995 VB denotes regulated
T7364 16983-16985 VB denotes is
T7363 16978-16982 NN denotes NFκB
T7362 16975-16977 IN denotes of
T7361 16964-16974 NN denotes activation
T7360 16959-16963 IN denotes that
T7359 16951-16958 NN denotes reports
T7358 16942-16950 JJ denotes previous
T7357 16937-16941 IN denotes with
T7356 16926-16936 JJ denotes consistent
T7355 16923-16925 VB denotes is
T7354 16917-16922 WDT denotes which
T7353 16915-16916 -COMMA- denotes ,
T7352 16908-16915 NN denotes pathway
T7351 16898-16907 NN denotes signaling
T7350 16888-16897 NN denotes TLR4/NFκB
T7349 16884-16887 DT denotes the
T7348 16881-16883 IN denotes of
T7347 16870-16880 NN denotes activation
T7346 16859-16869 VB denotes stimulates
T7345 16855-16858 NN denotes ICH
T7344 16850-16854 IN denotes that
T7343 16842-16849 VB denotes suggest
T7342 16837-16841 NN denotes data
T7341 16833-16836 PRP-DOLLAR- denotes Our
T7340 16827-16831 NN denotes TLR4
T7339 16824-16826 IN denotes of
T7338 16813-16823 NN denotes expression
T7337 16809-16812 DT denotes the
T7336 16806-16808 IN denotes of
T7335 16801-16805 DT denotes that
T7334 16798-16800 TO denotes to
T7333 16790-16797 JJ denotes similar
T7332 16786-16789 VB denotes was
T7331 16781-16785 NN denotes NFκB
T7330 16778-16780 IN denotes of
T7329 16767-16777 NN denotes activation
T7328 16763-16766 DT denotes the
T7327 16759-16762 CC denotes and
T7326 16753-16758 NN denotes p-IκB
T7325 16750-16752 IN denotes of
T7324 16739-16749 NN denotes expression
T7323 16735-16738 DT denotes the
T7322 16732-16734 IN denotes of
T7321 16724-16731 NN denotes profile
T7288 16534-16540 JJ denotes immune
T7287 16527-16533 JJ denotes innate
T7286 16522-16526 IN denotes with
T7285 16511-16521 VB denotes associated
T7284 16505-16510 NN denotes genes
T7283 16502-16504 IN denotes of
T7282 16488-16501 NN denotes transcription
T7281 16478-16487 VB denotes initiates
T7280 16472-16477 WDT denotes which
T7279 16470-16471 -COMMA- denotes ,
T7278 16466-16470 NN denotes NFκB
T7277 16463-16465 IN denotes of
T7276 16449-16462 NN denotes translocation
T7275 16441-16448 JJ denotes nuclear
T7274 16438-16440 IN denotes in
T7273 16428-16437 VB denotes resulting
T7272 16426-16427 -COMMA- denotes ,
T7271 16415-16426 NN denotes degradation
T7270 16411-16414 CC denotes and
T7269 16395-16410 NN denotes phosphorylation
T7268 16390-16394 NN denotes IκBα
T7267 16379-16389 VB denotes stimulates
T7266 16374-16378 NN denotes TLR4
T7265 16371-16373 IN denotes of
T7264 16360-16370 NN denotes Activation
T7263 16351-16358 NN denotes pathway
T7262 16341-16350 NN denotes signaling
T7261 16327-16340 JJ denotes TLR4-mediated
T7260 16323-16326 DT denotes the
T7259 16320-16322 IN denotes in
T7258 16309-16319 RB denotes downstream
T7257 16302-16308 NN denotes factor
T7256 16288-16301 NN denotes transcription
T7255 16278-16287 JJ denotes important
T7254 16275-16277 DT denotes an
T7253 16272-16274 VB denotes is
T7252 16267-16271 NN denotes NFκB
T7251 16259-16265 NN denotes brains
T7250 16247-16258 JJ denotes hemorrhagic
T7249 16244-16246 IN denotes in
T7248 16239-16243 NN denotes NFκB
T7247 16236-16238 IN denotes of
T7246 16227-16235 NN denotes activity
T7245 16223-16226 DT denotes the
T7244 16219-16222 CC denotes and
T7243 16213-16218 NN denotes p-IκB
T7242 16209-16212 DT denotes the
T7241 16199-16208 VB denotes detecting
T7240 16196-16198 IN denotes by
T7239 16186-16195 NN denotes signaling
T7238 16181-16185 NN denotes NFκB
T7237 16167-16180 JJ denotes TLR4-mediated
T7236 16164-16166 IN denotes of
T7235 16153-16163 NN denotes activation
T7234 16149-16152 DT denotes the
T7233 16139-16148 VB denotes evaluated
T7232 16136-16138 PRP denotes we
T7231 16134-16135 -COMMA- denotes ,
T7230 16129-16134 NN denotes study
T7229 16121-16128 JJ denotes present
T7228 16117-16120 DT denotes the
T7227 16114-16116 IN denotes in
T7226 16112-16113 -COMMA- denotes ,
T7225 16109-16112 NN denotes ICH
T7224 16103-16108 IN denotes after
T7223 16097-16102 NN denotes brain
T7222 16093-16096 DT denotes the
T7221 16090-16092 IN denotes in
T7220 16080-16089 NN denotes responses
T7219 16067-16079 JJ denotes inflammatory
T7218 16057-16066 VB denotes increased
T7217 16053-16056 DT denotes the
T7216 16042-16052 VB denotes underlying
T7215 16031-16041 NN denotes mechanisms
T7214 16027-16030 DT denotes the
T7213 16015-16026 VB denotes investigate
T7212 16012-16014 TO denotes To
T7211 16001-16010 NN denotes responses
T7210 15988-16000 JJ denotes inflammatory
T7209 15984-15987 CC denotes and
T7208 15970-15983 JJ denotes immunological
T7207 15960-15969 VB denotes regulates
T7206 15956-15959 CC denotes and
T7205 15946-15955 VB denotes activates
T7204 15938-15945 NN denotes pathway
T7203 15919-15937 NN denotes TLR4-mediated-NFκB
T7202 15914-15918 IN denotes that
T7201 15905-15913 VB denotes believed
T7200 15901-15904 RB denotes now
T7199 15898-15900 VB denotes is
T7198 15895-15897 PRP denotes It
T7197 15892-15893 -RRB- denotes ]
T7196 15890-15892 CD denotes 18
T7195 15889-15890 -LRB- denotes [
T7194 15883-15888 NN denotes death
T7193 15878-15882 NN denotes cell
T7192 15874-15877 CC denotes and
T7191 15863-15873 NN denotes hemorrhage
T7190 15860-15862 IN denotes of
T7189 15853-15859 NN denotes growth
T7188 15843-15852 JJ denotes secondary
T7187 15838-15842 IN denotes with
T7186 15827-15837 VB denotes associated
T7185 15823-15826 VB denotes are
T7184 15817-15822 WDT denotes which
T7183 15815-15816 -COMMA- denotes ,
T7182 15806-15815 NN denotes responses
T7181 15793-15805 JJ denotes inflammatory
T7180 15783-15792 VB denotes initiates
T7179 15779-15782 NN denotes ICH
T7178 15774-15778 IN denotes that
T7177 15761-15773 VB denotes demonstrated
T7176 15753-15760 NN denotes studies
T7175 15746-15752 JJ denotes Recent
T7174 15741-15744 NN denotes ICH
T7173 15735-15740 IN denotes after
T7172 15728-15734 NN denotes tissue
T7171 15722-15727 NN denotes brain
T7170 15718-15721 DT denotes the
T7169 15715-15717 IN denotes in
T7168 15705-15714 NN denotes responses
T7167 15692-15704 JJ denotes inflammatory
T7166 15688-15691 DT denotes the
T7165 15685-15687 IN denotes of
T7164 15674-15684 NN denotes triggering
T7163 15670-15673 DT denotes the
T7162 15667-15669 TO denotes to
T7161 15659-15666 JJ denotes related
T7160 15656-15658 VB denotes be
T7159 15652-15655 MD denotes may
T7158 15647-15651 NN denotes TLR4
T7157 15644-15646 IN denotes of
T7156 15633-15643 NN denotes expression
T7155 15623-15632 VB denotes increased
T7154 15618-15622 IN denotes that
T7153 15608-15617 VB denotes indicated
T7152 15603-15607 NN denotes data
T7151 15597-15602 DT denotes These
T7150 15589-15595 NN denotes tracts
T7149 15582-15588 NN denotes matter
T7148 15576-15581 JJ denotes white
T7147 15571-15575 DT denotes some
T7146 15567-15570 CC denotes and
T7145 15565-15566 -COMMA- denotes ,
T7144 15559-15565 NN denotes nuclei
T7143 15550-15558 JJ denotes thalamic
T7142 15548-15549 -COMMA- denotes ,
T7141 15542-15548 NN denotes cortex
T7140 15540-15541 -COMMA- denotes ,
T7139 15529-15540 NN denotes hippocampus
T7138 15525-15528 DT denotes the
T7137 15523-15524 -COMMA- denotes ,
T7136 15518-15523 NN denotes areas
T7135 15502-15517 JJ denotes peri-hemorrhage
T7134 15499-15501 IN denotes in
T7133 15487-15498 VB denotes distributed
T7132 15474-15486 RB denotes consistently
T7131 15470-15473 VB denotes was
T7130 15468-15469 -COMMA- denotes ,
T7129 15448-15468 NN denotes immunohistochemistry
T7128 15445-15447 IN denotes by
T7127 15436-15444 VB denotes detected
T7126 15434-15435 -COMMA- denotes ,
T7125 15427-15434 NN denotes protein
T7576 18280-18286 NN denotes damage
T7575 18274-18279 NN denotes brain
T7574 18262-18273 JJ denotes ICH-induced
T7573 18259-18261 IN denotes of
T7572 18248-18258 NN denotes prevention
T7571 18244-18247 DT denotes the
T7570 18240-18243 IN denotes for
T7569 18233-18239 NN denotes target
T7568 18221-18232 JJ denotes therapeutic
T7567 18219-18220 DT denotes a
T7566 18216-18218 VB denotes be
T7565 18212-18215 MD denotes may
T7564 18206-18211 WDT denotes which
T7563 18204-18205 -COMMA- denotes ,
T7562 18201-18204 NN denotes ICH
T7561 18198-18200 IN denotes of
T7560 18185-18197 NN denotes pathogenesis
T7559 18181-18184 DT denotes the
T7558 18178-18180 IN denotes in
T7557 18165-18177 VB denotes participates
T7556 18155-18164 NN denotes signaling
T7555 18150-18154 NN denotes NFκB
T7554 18136-18149 JJ denotes TLR4-mediated
T7553 18131-18135 IN denotes that
T7552 18122-18130 VB denotes suggests
T7551 18116-18121 WDT denotes which
T7550 18114-18115 -COMMA- denotes ,
T7549 18111-18114 NN denotes ICH
T7548 18098-18110 JJ denotes experimental
T7547 18095-18097 IN denotes of
T7546 18089-18094 NN denotes model
T7545 18085-18088 NN denotes rat
T7544 18083-18084 DT denotes a
T7543 18080-18082 IN denotes in
T7542 18073-18079 NN denotes tissue
T7541 18067-18072 NN denotes brain
T7540 18064-18066 IN denotes in
T7539 18054-18063 NN denotes signaling
T7538 18049-18053 NN denotes NFκB
T7537 18035-18048 JJ denotes TLR4-mediated
T7124 15422-15426 NN denotes TLR4
T7123 15418-15421 DT denotes The
T7122 15407-15416 RB denotes afterward
T7121 15402-15406 NN denotes days
T7120 15400-15401 CD denotes 7
T7119 15396-15399 IN denotes for
T7118 15390-15395 NN denotes level
T7117 15385-15389 JJ denotes high
T7116 15383-15384 DT denotes a
T7115 15380-15382 IN denotes at
T7114 15369-15379 VB denotes maintained
T7113 15365-15368 CC denotes and
T7112 15358-15364 NN denotes insult
T7111 15354-15357 NN denotes ICH
T7110 15350-15353 DT denotes the
T7109 15344-15349 IN denotes after
T7108 15338-15343 NN denotes hours
T7107 15336-15337 CD denotes 6
T7106 15333-15335 IN denotes as
T7105 15327-15332 RB denotes early
T7104 15324-15326 RB denotes as
T7103 15316-15323 VB denotes started
T7102 15308-15315 NN denotes changes
T7101 15302-15307 DT denotes These
T7100 15294-15300 NN denotes tissue
T7099 15288-15293 NN denotes brain
T7098 15285-15287 IN denotes in
T7097 15276-15284 JJ denotes elevated
T7096 15262-15275 RB denotes significantly
T7095 15258-15261 NN denotes ICH
T7094 15252-15257 IN denotes after
T7093 15244-15251 NN denotes protein
T7092 15239-15243 NN denotes TLR4
T7091 15236-15238 IN denotes of
T7090 15225-15235 NN denotes expression
T7089 15221-15224 DT denotes the
T7088 15218-15220 IN denotes as
T7087 15213-15217 RB denotes well
T7086 15210-15212 RB denotes as
T7085 15205-15209 NN denotes TLR4
T7084 15202-15204 IN denotes of
T7083 15188-15201 NN denotes transcription
T7082 15183-15187 IN denotes that
T7081 15176-15182 VB denotes showed
T7080 15171-15175 NN denotes data
T7079 15167-15170 PRP-DOLLAR- denotes Our
T7078 15158-15165 NN denotes protein
T7077 15154-15157 CC denotes and
T7076 15149-15153 NN denotes mRNA
T7075 15144-15148 NN denotes TLR4
T7074 15140-15143 DT denotes the
T7073 15131-15139 VB denotes detected
T6902 14150-14152 CD denotes 17
T6901 14149-14150 -LRB- denotes [
T6900 14145-14148 NN denotes ICH
T6899 14142-14144 IN denotes by
T6898 14133-14141 VB denotes produced
T6897 14126-14132 NN denotes damage
T6896 14117-14125 JJ denotes neuronal
T6895 14113-14116 CC denotes and
T6894 14111-14112 -COMMA- denotes ,
T6893 14100-14111 NN denotes dysfunction
T6892 14089-14099 JJ denotes behavioral
T6891 14087-14088 -COMMA- denotes ,
T6890 14075-14087 NN denotes inflammation
T6889 14068-14074 NN denotes reduce
T6888 14065-14067 IN denotes as
T6887 14060-14064 JJ denotes such
T6886 14058-14059 -COMMA- denotes ,
T6885 14055-14058 NN denotes ICH
T6884 14042-14054 JJ denotes experimental
T6883 14039-14041 IN denotes on
T6882 14032-14038 NN denotes effect
T6881 14020-14031 JJ denotes therapeutic
T6880 14018-14019 DT denotes a
T6879 14013-14017 VB denotes have
T6878 14010-14012 TO denotes to
T6877 14004-14009 VB denotes shown
T6876 13999-14003 VB denotes been
T6875 13995-13998 VB denotes has
T6874 13986-13994 NN denotes activity
T6873 13981-13985 NN denotes NFκB
T6872 13978-13980 IN denotes of
T6871 13967-13977 NN denotes Inhibition
T6870 13964-13965 -RRB- denotes ]
T6869 13962-13964 CD denotes 16
T6868 13961-13962 -LRB- denotes [
T6867 13957-13960 NN denotes ICH
T6866 13951-13956 IN denotes after
T6865 13945-13950 NN denotes death
T6864 13940-13944 NN denotes cell
T6863 13927-13939 JJ denotes perilesional
T6862 13924-13926 IN denotes of
T6861 13911-13923 NN denotes pathobiology
T6860 13907-13910 DT denotes the
T6859 13904-13906 TO denotes to
T6858 13892-13903 VB denotes contributes
T6857 13888-13891 CC denotes and
T6856 13878-13887 NN denotes responses
T6855 13865-13877 JJ denotes inflammatory
T6854 13855-13864 VB denotes initiates
T6853 13850-13854 NN denotes NFκB
T6852 13847-13849 IN denotes of
T6851 13836-13846 NN denotes Activation
T6850 13833-13834 -RRB- denotes ]
T6849 13831-13833 CD denotes 15
T6848 13830-13831 -LRB- denotes [
T6847 13824-13829 NN denotes genes
T6846 13817-13823 NN denotes target
T6845 13808-13816 VB denotes selected
T6844 13805-13807 IN denotes of
T6843 13794-13804 NN denotes expression
T6842 13790-13793 DT denotes the
T6841 13785-13789 IN denotes with
T6840 13774-13784 VB denotes associated
T6839 13771-13773 VB denotes is
T6838 13765-13770 WDT denotes which
T6837 13763-13764 -COMMA- denotes ,
T6836 13760-13763 NN denotes ICH
T6835 13757-13759 TO denotes to
T6834 13748-13756 NN denotes response
T6833 13745-13747 IN denotes in
T6832 13740-13744 NN denotes week
T6831 13738-13739 DT denotes a
T6830 13732-13737 JJ denotes least
T6829 13729-13731 IN denotes at
T6828 13725-13728 IN denotes for
T6827 13716-13724 VB denotes persists
T6826 13712-13715 CC denotes and
T6825 13704-13711 NN denotes minutes
T6824 13697-13703 IN denotes within
T6823 13690-13696 VB denotes occurs
T6822 13679-13689 NN denotes activation
T6821 13674-13678 NN denotes NFκB
T6820 13671-13672 -RRB- denotes ]
T6819 13669-13671 CD denotes 14
T6818 13668-13669 -LRB- denotes [
T6817 13664-13667 NN denotes ICH
T6816 13658-13663 IN denotes after
T6815 13645-13657 NN denotes perihematoma
T6814 13642-13644 IN denotes of
T6813 13635-13641 NN denotes region
T6812 13631-13634 DT denotes the
T6811 13628-13630 IN denotes in
T6810 13618-13627 VB denotes increased
T6809 13613-13617 NN denotes NFκB
T6808 13608-13612 IN denotes that
T6807 13599-13607 VB denotes reported
T6806 13594-13598 VB denotes been
T6805 13590-13593 VB denotes has
T6804 13587-13589 PRP denotes It
T6803 13574-13585 NN denotes pathologies
T6802 13568-13573 NN denotes brain
T6801 13565-13567 IN denotes in
T6800 13552-13564 NN denotes inflammation
T6799 13541-13551 VB denotes regulating
T6798 13538-13540 IN denotes in
T6797 13533-13537 NN denotes role
T6796 13529-13532 JJ denotes key
T6795 13527-13528 DT denotes a
T6794 13521-13526 VB denotes plays
T6793 13516-13520 RB denotes also
T6792 13512-13515 CC denotes and
T6791 13510-13511 -RRB- denotes ]
T6790 13508-13510 CD denotes 13
T6789 13506-13507 -COMMA- denotes ,
T6788 13504-13506 CD denotes 12
T6787 13503-13504 -LRB- denotes [
T6786 13490-13502 NN denotes inflammation
T6785 13486-13489 CC denotes and
T6784 13476-13485 NN denotes responses
T6783 13469-13475 JJ denotes immune
T6782 13464-13468 IN denotes with
T6781 13453-13463 VB denotes associated
T6780 13447-13452 NN denotes genes
T6779 13444-13446 IN denotes of
T6778 13430-13443 NN denotes transcription
T6777 13420-13429 VB denotes initiates
T6776 13414-13419 WDT denotes which
T6775 13412-13413 -COMMA- denotes ,
T6774 13406-13412 NN denotes factor
T6773 13392-13405 NN denotes transcription
T6772 13384-13391 JJ denotes nuclear
T6771 13374-13383 JJ denotes important
T6770 13371-13373 DT denotes an
T6769 13368-13370 VB denotes is
T6768 13366-13367 -RRB- denotes )
T6767 13362-13366 NN denotes NFκB
T6766 13361-13362 -LRB- denotes (
T6765 13346-13360 NN denotes factor-kappa-B
T6764 13338-13345 JJ denotes nuclear
T6763 13331-13337 NN denotes factor
T6762 13317-13330 NN denotes Transcription
T6761 13308-13315 JJ denotes unclear
T6760 13305-13307 VB denotes is
T6759 13301-13304 NN denotes ICH
T6758 13295-13300 IN denotes after
T6757 13288-13294 NN denotes tissue
T6756 13282-13287 NN denotes brain
T6755 13278-13281 DT denotes the
T6754 13275-13277 IN denotes in
T6753 13265-13274 VB denotes regulated
T6752 13261-13264 CC denotes and
T6751 13251-13260 VB denotes activated
T6750 13248-13250 VB denotes is
T6749 13238-13247 NN denotes responses
T6748 13225-13237 JJ denotes inflammatory
T6747 13221-13224 DT denotes the
T6746 13217-13220 WRB denotes how
T6745 13215-13216 -COMMA- denotes ,
T6744 13208-13215 RB denotes However
T6743 13203-13206 NN denotes ICH
T6742 13200-13202 IN denotes of
T6741 13187-13199 NN denotes pathogenesis
T6740 13183-13186 DT denotes the
T6739 13180-13182 IN denotes in
T7320 16715-16723 JJ denotes temporal
T7319 16711-16714 DT denotes The
T7318 16706-16709 NN denotes ICH
T7317 16700-16705 IN denotes after
T7316 16693-16699 NN denotes tissue
T7315 16687-16692 NN denotes brain
T7314 16684-16686 IN denotes in
T7313 16674-16683 VB denotes increased
T7312 16660-16673 RB denotes significantly
T7311 16655-16659 VB denotes were
T7310 16650-16654 NN denotes NFκB
T7309 16647-16649 IN denotes of
T7308 16638-16646 NN denotes activity
T7307 16634-16637 DT denotes the
T7306 16630-16633 CC denotes and
T7305 16626-16629 NN denotes IκB
T7304 16623-16625 IN denotes of
T7303 16607-16622 NN denotes phosphorylation
T7302 16604-16606 IN denotes of
T7301 16597-16603 NN denotes levels
T7300 16593-16596 DT denotes the
T7299 16588-16592 IN denotes that
T7298 16579-16587 VB denotes observed
T7297 16576-16578 PRP denotes We
T7296 16573-16574 -RRB- denotes ]
T7295 16572-16573 CD denotes 6
T7294 16570-16571 -COMMA- denotes ,
T7293 16569-16570 CD denotes 5
T7292 16568-16569 -LRB- denotes [
T7291 16555-16567 NN denotes inflammation
T7290 16551-16554 CC denotes and
T7289 16541-16550 NN denotes responses
T6738 13170-13179 JJ denotes important
T6737 13167-13169 VB denotes be
T6736 13163-13166 MD denotes may
T6735 13161-13162 -COMMA- denotes ,
T6734 13151-13161 NN denotes complement
T6733 13147-13150 CC denotes and
T6732 13145-13146 -COMMA- denotes ,
T6731 13130-13145 NN denotes immunoglobulins
T6730 13128-13129 -COMMA- denotes ,
T6729 13118-13128 NN denotes leukocytes
T6728 13116-13117 -COMMA- denotes ,
T6727 13107-13116 NN denotes cytokines
T6726 13105-13106 -COMMA- denotes ,
T6725 13096-13105 NN denotes molecules
T6724 13087-13095 NN denotes adhesion
T6723 13077-13086 VB denotes including
T6722 13075-13076 -COMMA- denotes ,
T6721 13067-13075 NN denotes response
T6720 13054-13066 JJ denotes inflammatory
T6719 13050-13053 DT denotes the
T6718 13047-13049 IN denotes of
T6717 13034-13046 NN denotes constituents
T6716 13026-13033 JJ denotes Various
T6715 13021-13024 NN denotes ICH
T6714 13017-13020 IN denotes for
T6713 13009-13016 NN denotes targets
T6712 12997-13008 JJ denotes therapeutic
T6711 12993-12996 JJ denotes new
T6710 12985-12992 VB denotes provide
T6709 12979-12984 MD denotes could
T6708 12973-12978 WDT denotes which
T6707 12971-12972 -COMMA- denotes ,
T6706 12965-12971 NN denotes injury
T6705 12959-12964 NN denotes brain
T6704 12951-12958 VB denotes induced
T6703 12947-12950 NN denotes ICH
T6702 12943-12946 DT denotes the
T6701 12939-12942 IN denotes for
T6700 12927-12938 JJ denotes responsible
T6699 12923-12926 VB denotes are
T6698 12913-12922 NN denotes responses
T6697 12900-12912 JJ denotes inflammatory
T6696 12896-12899 DT denotes The
T6695 12893-12894 -RRB- denotes ]
T6694 12891-12893 CD denotes 11
T6693 12890-12891 -LRB- denotes [
T6692 12883-12889 NN denotes agents
T6691 12877-12882 DT denotes these
T6690 12874-12876 IN denotes of
T6689 12869-12873 JJ denotes many
T6688 12859-12868 VB denotes producing
T6687 12856-12858 IN denotes of
T6586 12258-12266 JJ denotes ischemic
T6585 12255-12257 IN denotes of
T6584 12250-12254 DT denotes that
T6583 12245-12249 IN denotes than
T6582 12238-12244 JJ denotes higher
T6581 12235-12237 VB denotes is
T6580 12231-12234 NN denotes ICH
T6579 12228-12230 IN denotes of
T6578 12218-12227 NN denotes mortality
T6577 12214-12217 DT denotes The
T6576 12211-12212 -RRB- denotes ]
T6575 12210-12211 CD denotes 1
T6574 12209-12210 -LRB- denotes [
T6573 12202-12208 NN denotes stroke
T6572 12193-12201 JJ denotes ischemic
T6571 12190-12192 IN denotes of
T6570 12180-12189 NN denotes treatment
T6569 12167-12179 JJ denotes thrombolytic
T6568 12163-12166 DT denotes the
T6567 12160-12162 IN denotes of
T6566 12147-12159 NN denotes complication
T6565 12145-12146 DT denotes a
T6564 12142-12144 IN denotes as
T6563 12132-12141 NN denotes frequency
T6562 12121-12131 VB denotes increasing
T6561 12116-12120 IN denotes with
T6560 12109-12115 VB denotes occurs
T6559 12105-12108 CC denotes and
T6558 12103-12104 -COMMA- denotes ,
T6557 12096-12103 NN denotes strokes
T6556 12092-12095 DT denotes all
T6555 12089-12091 IN denotes of
T6554 12087-12088 NN denotes %
T6553 12082-12087 CD denotes 10–15
T6552 12071-12081 VB denotes represents
T6551 12069-12070 -RRB- denotes )
T6550 12066-12069 NN denotes ICH
T6549 12065-12066 -LRB- denotes (
T6548 12054-12064 NN denotes hemorrhage
T6547 12039-12053 JJ denotes Intra-cerebral
T7072 15127-15130 CC denotes and
T7071 15123-15126 NN denotes ICH
T7070 15110-15122 JJ denotes experimental
T7069 15107-15109 IN denotes of
T7068 15101-15106 NN denotes model
T7067 15097-15100 NN denotes rat
T7066 15093-15096 DT denotes the
T7065 15081-15092 VB denotes established
T7064 15078-15080 PRP denotes we
T7063 15076-15077 -COMMA- denotes ,
T7062 15071-15076 NN denotes study
T7061 15063-15070 JJ denotes present
T7060 15059-15062 DT denotes the
T7059 15056-15058 IN denotes In
T7058 15051-15054 NN denotes ICH
T7057 15047-15050 CC denotes and
T7056 15037-15046 NN denotes signaling
T7055 15032-15036 NN denotes NFκB
T7054 15018-15031 JJ denotes TLR4-mediated
T7053 15010-15017 IN denotes between
T7052 14997-15009 NN denotes relationship
T7051 14993-14996 DT denotes the
T7050 14989-14992 CC denotes and
T7049 14984-14988 NN denotes role
T7048 14980-14983 DT denotes the
T7047 14968-14979 VB denotes investigate
T7046 14965-14967 TO denotes to
T7045 14956-14964 VB denotes directed
T7044 14951-14955 VB denotes been
T7043 14946-14950 VB denotes have
T7042 14938-14945 NN denotes studies
T7041 14934-14937 JJ denotes few
T7040 14929-14933 RB denotes very
T7039 14927-14928 -COMMA- denotes ,
T7038 14926-14927 -RRB- denotes ]
T7037 14924-14926 CD denotes 17
T7036 14923-14924 -LRB- denotes [
T7035 14910-14922 NN denotes constituents
T7034 14903-14909 NN denotes plasma
T7033 14896-14902 CC denotes and/or
T7032 14890-14895 NN denotes cells
T7031 14884-14889 NN denotes blood
T7030 14880-14883 JJ denotes red
T7029 14877-14879 IN denotes by
T7028 14869-14876 VB denotes induced
T7027 14858-14868 NN denotes activation
T7026 14849-14857 NN denotes receptor
T7025 14839-14848 NN denotes glutamate
T7024 14836-14838 CC denotes or
T7023 14829-14835 NN denotes stress
T7022 14819-14828 JJ denotes oxidative
T7021 14815-14818 DT denotes the
T7020 14812-14814 TO denotes to
T7019 14801-14811 VB denotes attributed
T7018 14797-14800 VB denotes was
T7017 14792-14796 NN denotes NFκB
T7016 14789-14791 IN denotes of
T7015 14778-14788 NN denotes activation
T7014 14774-14777 DT denotes the
T7013 14769-14773 IN denotes that
T7012 14759-14768 VB denotes indicated
T7011 14751-14758 NN denotes reports
T7010 14742-14750 JJ denotes previous
T7009 14733-14741 IN denotes Although
T7008 14730-14731 -RRB- denotes ]
T7007 14729-14730 CD denotes 8
T7006 14727-14728 -COMMA- denotes ,
T7005 14726-14727 CD denotes 7
T7004 14725-14726 -LRB- denotes [
T7003 14718-14724 NN denotes injury
T7002 14709-14717 JJ denotes ischemic
T7001 14700-14708 JJ denotes cerebral
T7000 14696-14699 CC denotes and
T6999 14687-14695 NN denotes diseases
T6998 14683-14686 NN denotes CNS
T6997 14672-14682 JJ denotes autoimmune
T6996 14669-14671 CC denotes or
T6995 14656-14668 JJ denotes inflammatory
T6994 14653-14655 IN denotes as
T6993 14648-14652 JJ denotes such
T6992 14646-14647 -COMMA- denotes ,
T6991 14638-14646 NN denotes diseases
T6990 14631-14637 NN denotes system
T6989 14629-14630 -RRB- denotes )
T6988 14626-14629 NN denotes CNS
T6987 14625-14626 -LRB- denotes (
T6986 14617-14624 JJ denotes nervous
T6985 14609-14616 JJ denotes central
T6984 14601-14608 JJ denotes several
T6983 14598-14600 IN denotes in
T6982 14589-14597 VB denotes involved
T6981 14586-14588 VB denotes be
T6980 14583-14585 TO denotes to
T6979 14574-14582 VB denotes reported
T6978 14569-14573 VB denotes been
T6977 14565-14568 VB denotes has
T6976 14563-14564 -COMMA- denotes ,
T6975 14553-14563 VB denotes recognized
T6974 14549-14552 NN denotes TLR
T6973 14539-14548 JJ denotes mammalian
T6972 14533-14538 JJ denotes first
T6971 14529-14532 DT denotes the
T6970 14527-14528 -COMMA- denotes ,
T6969 14523-14527 NN denotes TLR4
T6968 14520-14521 -RRB- denotes ]
T6967 14518-14520 CD denotes 13
T6966 14516-14517 -COMMA- denotes ,
T6965 14514-14516 CD denotes 12
T6964 14513-14514 -LRB- denotes [
T6963 14508-14512 NN denotes NFκB
T6962 14505-14507 IN denotes of
T6961 14494-14504 NN denotes activation
T6960 14490-14493 DT denotes the
T6959 14480-14489 VB denotes stimulate
T6958 14473-14479 RB denotes mainly
T6957 14464-14472 NN denotes pathways
T6956 14454-14463 NN denotes signaling
T6955 14441-14453 JJ denotes TLR-mediated
T6954 14438-14439 -RRB- denotes ]
T6953 14437-14438 CD denotes 4
T6952 14436-14437 -LRB- denotes [
T6951 14427-14435 NN denotes immunity
T6950 14418-14426 JJ denotes adaptive
T6949 14414-14417 CC denotes and
T6948 14407-14413 JJ denotes innate
T6947 14404-14406 IN denotes of
T6946 14394-14403 NN denotes induction
T6945 14390-14393 DT denotes the
T6944 14387-14389 IN denotes in
T6943 14382-14386 NN denotes role
T6942 14373-14381 JJ denotes critical
T6941 14371-14372 DT denotes a
T6940 14366-14370 VB denotes play
T6939 14362-14365 CC denotes and
T6938 14352-14361 NN denotes molecules
T6937 14339-14351 NN denotes transduction
T6936 14332-14338 NN denotes signal
T6935 14329-14331 IN denotes of
T6934 14322-14328 NN denotes family
T6933 14320-14321 DT denotes a
T6932 14316-14319 VB denotes are
T6931 14314-14315 -RRB- denotes )
T6930 14310-14314 NN denotes TLRs
T6929 14309-14310 -LRB- denotes (
T6928 14299-14308 NN denotes receptors
T6927 14289-14298 JJ denotes Toll-like
T6926 14284-14287 NN denotes ICH
T6925 14280-14283 IN denotes for
T6924 14273-14279 NN denotes method
T6923 14257-14272 JJ denotes neuroprotective
T6922 14253-14256 JJ denotes new
T6921 14251-14252 DT denotes a
T6920 14243-14250 VB denotes seeking
T6919 14239-14242 IN denotes for
T6918 14230-14238 JJ denotes critical
T6917 14227-14229 VB denotes is
T6916 14223-14226 NN denotes ICH
T6915 14220-14222 TO denotes to
T6914 14210-14219 VB denotes subjected
T6913 14204-14209 NN denotes brain
T6912 14200-14203 DT denotes the
T6911 14197-14199 IN denotes in
T6910 14187-14196 VB denotes activated
T6909 14184-14186 VB denotes is
T6908 14179-14183 NN denotes NFκB
T6907 14175-14178 WRB denotes how
T6906 14169-14174 IN denotes about
T6905 14159-14168 NN denotes knowledge
T6904 14155-14158 DT denotes The
T6903 14152-14153 -RRB- denotes ]
T6678 12803-12811 NN denotes reaction
T6686 12848-12855 JJ denotes capable
T6685 12843-12847 RB denotes also
T6684 12839-12842 VB denotes are
T6683 12832-12838 PRP denotes itself
T6682 12826-12831 NN denotes cells
T6681 12820-12825 NN denotes brain
T6680 12816-12819 DT denotes the
T6679 12812-12815 CC denotes and
T6677 12790-12802 JJ denotes inflammatory
T6676 12787-12789 DT denotes an
T6675 12780-12786 VB denotes induce
T6674 12776-12779 CC denotes and
T6673 12770-12775 NN denotes brain
T6672 12766-12769 DT denotes the
T6671 12763-12765 TO denotes to
T6670 12757-12762 VB denotes enter
T6669 12751-12756 MD denotes might
T6668 12745-12750 NN denotes blood
T6667 12741-12744 DT denotes the
T6666 12736-12740 IN denotes from
T6665 12726-12735 NN denotes mediators
T6664 12713-12725 JJ denotes inflammatory
T6663 12711-12712 -COMMA- denotes ,
T6662 12708-12711 NN denotes ICH
T6661 12702-12707 IN denotes After
T6660 12694-12700 NN denotes events
T6659 12678-12693 JJ denotes cerebrovascular
T6658 12675-12677 IN denotes in
T6657 12666-12674 VB denotes involved
T6656 12662-12665 VB denotes are
T6655 12652-12661 NN denotes processes
T6654 12639-12651 JJ denotes inflammatory
T6653 12634-12638 IN denotes that
T6652 12625-12633 NN denotes evidence
T6651 12614-12624 VB denotes increasing
T6650 12611-12613 VB denotes is
T6649 12605-12610 EX denotes there
T6648 12603-12604 -COMMA- denotes ,
T6647 12595-12603 NN denotes addition
T6646 12592-12594 IN denotes In
T6645 12584-12590 NN denotes damage
T6644 12577-12583 NN denotes tissue
T6643 12571-12576 NN denotes brain
T6642 12564-12570 VB denotes induce
T6641 12560-12563 NN denotes ICH
T6640 12554-12559 IN denotes after
T6639 12543-12553 NN denotes components
T6638 12537-12542 NN denotes blood
T6637 12534-12536 IN denotes of
T6636 12525-12533 NN denotes toxicity
T6635 12521-12524 CC denotes and
T6634 12519-12520 -COMMA- denotes ,
T6633 12511-12519 NN denotes ischemia
T6632 12509-12510 -COMMA- denotes ,
T6631 12503-12509 NN denotes effect
T6630 12498-12502 NNP denotes Mass
T6629 12487-12496 JJ denotes effective
T6628 12483-12486 RB denotes not
T6627 12479-12482 VB denotes are
T6626 12475-12478 NN denotes ICH
T6625 12469-12474 IN denotes after
T6624 12462-12468 NN denotes tissue
T6623 12456-12461 NN denotes brain
T6622 12452-12455 DT denotes the
T6621 12449-12451 IN denotes of
T6620 12438-12448 NN denotes protection
T6619 12434-12437 CC denotes and
T6618 12426-12433 NN denotes disease
T6617 12421-12425 DT denotes this
T6616 12418-12420 IN denotes of
T6615 12408-12417 NN denotes treatment
T6614 12404-12407 IN denotes for
T6613 12397-12403 NN denotes method
T6612 12393-12396 DT denotes the
T6611 12391-12392 -COMMA- denotes ,
T6610 12378-12391 RB denotes Unfortunately
T6609 12375-12376 -RRB- denotes ]
T6608 12373-12375 CD denotes 10
T6607 12372-12373 -LRB- denotes [
T6606 12367-12371 NN denotes year
T6605 12363-12366 JJ denotes 1st
T6604 12359-12362 DT denotes the
T6603 12351-12358 VB denotes survive
T6602 12342-12350 NN denotes patients
T6601 12338-12341 DT denotes the
T6600 12335-12337 IN denotes of
T6599 12333-12334 NN denotes %
T6598 12331-12333 CD denotes 38
T6597 12326-12330 RB denotes Only
T6596 12318-12324 NN denotes months
T6595 12316-12317 CD denotes 3
T6594 12313-12315 IN denotes at
T6593 12301-12312 JJ denotes independent
T6592 12288-12300 RB denotes functionally
T6591 12284-12287 VB denotes are
T6590 12282-12283 NN denotes %
T6589 12280-12282 CD denotes 31
T6588 12275-12279 RB denotes Only
T6587 12267-12273 NN denotes stroke
T5734 11698-11702 VB denotes were
T5744 11758-11764 VB denotes showed
T5743 11750-11757 NN denotes Results
T5742 11744-11748 NN denotes EMSA
T5741 11740-11743 CC denotes and
T5740 11734-11739 NN denotes Blots
T5739 11726-11733 JJ denotes Western
T5738 11723-11725 IN denotes of
T5737 11715-11722 NN denotes methods
T5736 11712-11714 IN denotes by
T5735 11703-11711 VB denotes measured
T5733 11693-11697 NN denotes NFκB
T5732 11690-11692 IN denotes of
T5731 11681-11689 NN denotes activity
T5730 11677-11680 CC denotes and
T5729 11675-11676 -RRB- denotes )
T5728 11670-11675 NN denotes p-IκB
T5727 11669-11670 -LRB- denotes (
T5726 11661-11668 NN denotes kappa-B
T5725 11658-11660 IN denotes of
T5724 11648-11657 NN denotes inhibitor
T5723 11645-11647 IN denotes of
T5722 11629-11644 NN denotes phosphorylation
T5721 11625-11628 DT denotes the
T5720 11623-11624 -COMMA- denotes ,
T5719 11614-11623 NN denotes signaling
T5718 11609-11613 NN denotes NFκB
T5717 11595-11608 JJ denotes TLR4-mediated
T5716 11592-11594 IN denotes of
T5715 11581-11591 NN denotes activation
T5714 11577-11580 DT denotes the
T5713 11569-11576 VB denotes detectd
T5712 11566-11568 TO denotes To
T5711 11555-11564 NN denotes responses
T5710 11542-11554 JJ denotes inflammatory
T5709 11539-11541 TO denotes to
T5708 11531-11538 VB denotes related
T5707 11525-11530 NN denotes genes
T5706 11522-11524 IN denotes of
T5705 11508-11521 NN denotes transcription
T5704 11504-11507 DT denotes the
T5703 11494-11503 VB denotes regulates
T5702 11490-11493 CC denotes and
T5701 11480-11489 VB denotes activates
T5700 11476-11479 CC denotes and
T5699 11468-11475 NN denotes nucleus
T5698 11464-11467 DT denotes the
T5697 11459-11463 IN denotes into
T5696 11446-11458 VB denotes translocates
T5695 11441-11445 NN denotes NFκB
T5694 11439-11440 -COMMA- denotes ,
T5693 11435-11439 RB denotes Then
T5692 11432-11433 -RRB- denotes )
T5691 11428-11432 NN denotes NFκB
T5690 11427-11428 -LRB- denotes (
T5689 11416-11426 NN denotes NF-kappa-B
T5688 11411-11415 IN denotes with
T5687 11407-11410 NN denotes IκB
T5686 11395-11406 VB denotes dissociates
T5685 11389-11394 WDT denotes which
T5684 11387-11388 -COMMA- denotes ,
T5683 11386-11387 -RRB- denotes )
T5682 11383-11386 NN denotes IκB
T5681 11382-11383 -LRB- denotes (
T5680 11374-11381 NN denotes kappa-B
T5679 11371-11373 IN denotes of
T5678 11361-11370 NN denotes inhibitor
T5677 11358-11360 IN denotes of
T5676 11342-11357 NN denotes phosphorylation
T5675 11338-11341 DT denotes the
T5674 11330-11337 VB denotes induces
T5673 11325-11329 NN denotes TLR4
T5672 11322-11324 IN denotes of
T5671 11311-11321 NN denotes Activation
T5670 11301-11310 NN denotes Signaling
T5669 11290-11300 NN denotes NF-Kappa-B
T5668 11276-11289 JJ denotes TLR4-Mediated
T5667 11273-11275 IN denotes of
T5666 11262-11272 NN denotes Activation
T5665 11257-11260 CD denotes 3.4
T5461 11253-11254 -RRB- denotes )
T5460 11252-11253 CD denotes 3
T5459 11245-11251 NN denotes Figure
T5458 11244-11245 -LRB- denotes (
T5457 11237-11243 NN denotes tracts
T5456 11230-11236 NN denotes matter
T5455 11224-11229 JJ denotes white
T5454 11219-11223 DT denotes some
T5453 11215-11218 CC denotes and
T5452 11213-11214 -COMMA- denotes ,
T5451 11207-11213 NN denotes nuclei
T5450 11198-11206 JJ denotes thalamic
T5449 11196-11197 -COMMA- denotes ,
T5448 11190-11196 NN denotes cortex
T5447 11188-11189 -COMMA- denotes ,
T5446 11177-11188 NN denotes hippocampus
T5445 11173-11176 DT denotes the
T5444 11171-11172 -COMMA- denotes ,
T5443 11166-11171 NN denotes areas
T5442 11150-11165 JJ denotes peri-hemorrhage
T5441 11147-11149 IN denotes in
T5440 11134-11146 VB denotes demonstrated
T5439 11121-11133 RB denotes consistently
T5438 11117-11120 VB denotes was
T5437 11112-11116 NN denotes TLR4
T5436 11108-11111 IN denotes for
T5435 11091-11107 NN denotes immunoreactivity
T5434 11089-11090 -COMMA- denotes ,
T5433 11082-11089 RB denotes However
T5432 11073-11080 NN denotes control
T5431 11068-11072 NN denotes sham
T5430 11064-11067 CC denotes and
T5429 11057-11063 JJ denotes normal
T5428 11052-11056 IN denotes from
T5427 11045-11051 NN denotes tissue
T5426 11039-11044 NN denotes brain
T5425 11036-11038 IN denotes in
T5424 11025-11035 JJ denotes detectable
T5423 11021-11024 RB denotes not
T5422 11017-11020 VB denotes was
T5421 11000-11016 NN denotes immunoreactivity
T5420 10995-10999 NN denotes TLR4
T5419 10990-10994 IN denotes that
T5418 10983-10989 VB denotes showed
T5417 10975-10982 NN denotes Results
T5416 10972-10973 -RRB- denotes )
T5415 10969-10972 NN denotes IHC
T5414 10968-10969 -LRB- denotes (
T5413 10947-10967 NN denotes immunohistochemistry
T5412 10944-10946 IN denotes by
T5411 10935-10943 VB denotes detected
T5410 10931-10934 VB denotes was
T5409 10926-10930 NN denotes TLR4
T5408 10922-10925 DT denotes the
T5407 10920-10921 -COMMA- denotes ,
T5406 10913-10920 NN denotes protein
T5405 10908-10912 NN denotes TLR4
T5404 10905-10907 IN denotes of
T5403 10892-10904 NN denotes distribution
T5402 10888-10891 DT denotes the
T5401 10880-10887 VB denotes explore
T5400 10877-10879 TO denotes To
T5399 10873-10876 VB denotes ICH
T5398 10870-10872 TO denotes to
T5397 10860-10869 NNP denotes Subjected
T5396 10854-10859 NNP denotes Brain
T5395 10851-10853 IN denotes in
T5394 10846-10850 NN denotes TLR4
T5393 10843-10845 IN denotes of
T5392 10830-10842 NN denotes Distribution
T5391 10825-10828 CD denotes 3.3
T5806 12021-12022 -RRB- denotes )
T5805 12020-12021 CD denotes 4
T5804 12013-12019 NN denotes Figure
T5803 12012-12013 -LRB- denotes (
T5802 12006-12011 NN denotes p-IκB
T5801 12002-12005 DT denotes the
T5800 11999-12001 IN denotes of
T5799 11994-11998 DT denotes that
T5798 11991-11993 IN denotes as
T5797 11984-11990 NN denotes manner
T5796 11979-11983 JJ denotes same
T5795 11975-11978 DT denotes the
T5794 11972-11974 IN denotes in
T5793 11962-11971 VB denotes increased
T5792 11957-11961 RB denotes also
T5791 11953-11956 VB denotes was
T5790 11948-11952 NN denotes NFκB
T5789 11945-11947 IN denotes of
T5788 11936-11944 NN denotes activity
T5787 11932-11935 DT denotes the
T5786 11930-11931 -COMMA- denotes ,
T5785 11922-11930 VB denotes expected
T5784 11919-11921 IN denotes As
T5783 11916-11917 -RRB- denotes )
T5782 11915-11916 CD denotes 5
T5781 11908-11914 NNP denotes Figure
T5780 11906-11907 -COMMA- denotes ,
T5779 11903-11906 CD denotes .05
T5778 11901-11902 JJ denotes <
T5777 11899-11900 NN denotes P
T5776 11898-11899 -LRB- denotes (
T5775 11894-11897 NN denotes ICH
T5774 11888-11893 IN denotes after
T5773 11883-11887 NN denotes days
T5772 11881-11882 CD denotes 7
T5771 11878-11880 IN denotes on
T5770 11872-11877 NN denotes level
T5769 11867-11871 JJ denotes high
T5768 11865-11866 DT denotes a
T5767 11854-11864 VB denotes maintained
T5766 11850-11853 CC denotes and
T5765 11848-11849 -COMMA- denotes ,
T5764 11845-11848 NN denotes ICH
T5763 11839-11844 IN denotes after
T5762 11834-11838 NN denotes days
T5761 11832-11833 CD denotes 3
T5760 11829-11831 IN denotes on
T5759 11822-11828 VB denotes peaked
T5758 11820-11821 -COMMA- denotes ,
T5757 11819-11820 -RRB- denotes )
T5756 11816-11819 CD denotes .05
T5755 11814-11815 SYM denotes <
T5754 11812-11813 NN denotes P
T5753 11811-11812 -LRB- denotes (
T5752 11807-11810 NN denotes ICH
T5751 11801-11806 IN denotes after
T5750 11793-11800 NN denotes 6 hours
T5749 11790-11792 IN denotes at
T5748 11780-11789 VB denotes increased
T5747 11774-11779 NN denotes p-IκB
T5746 11770-11773 DT denotes the
T5745 11765-11769 IN denotes that
T5082 10819-10822 NN denotes ICH
T5081 10813-10818 IN denotes after
T5080 10808-10812 NN denotes mRNA
T5079 10803-10807 NN denotes TLR4
T5078 10799-10802 DT denotes the
T5077 10796-10798 IN denotes of
T5076 10788-10795 NN denotes profile
T5075 10779-10787 JJ denotes temporal
T5074 10775-10778 DT denotes the
T5073 10770-10774 IN denotes with
T5072 10759-10769 JJ denotes consistent
T5071 10755-10758 VB denotes was
T5070 10747-10754 NN denotes protein
T5069 10742-10746 NN denotes TLR4
T5068 10739-10741 IN denotes of
T5067 10727-10738 NN denotes observation
T5066 10722-10726 DT denotes This
T5065 10719-10720 -RRB- denotes )
T5064 10718-10719 CD denotes 2
T5063 10711-10717 NN denotes Figure
T5062 10709-10710 -COMMA- denotes ,
T5061 10706-10709 CD denotes .05
T5060 10704-10705 JJ denotes <
T5059 10702-10703 NN denotes P
T5058 10701-10702 -LRB- denotes (
T5057 10697-10700 NN denotes ICH
T5056 10691-10696 IN denotes after
T5055 10687-10690 NN denotes day
T5054 10683-10686 JJ denotes 7th
T5053 10679-10682 DT denotes the
T5052 10676-10678 IN denotes on
T5051 10670-10675 NN denotes level
T5050 10665-10669 JJ denotes high
T5049 10663-10664 DT denotes a
T5048 10660-10662 IN denotes at
T5047 10649-10659 VB denotes maintained
T5046 10643-10648 RB denotes still
T5045 10639-10642 CC denotes but
T5044 10629-10638 VB denotes decreased
T5043 10624-10628 RB denotes then
T5042 10620-10623 CC denotes and
T5041 10618-10619 -COMMA- denotes ,
T5040 10615-10618 NN denotes ICH
T5039 10609-10614 IN denotes after
T5038 10605-10608 NN denotes day
T5037 10601-10604 JJ denotes 3rd
T5036 10597-10600 DT denotes the
T5035 10594-10596 IN denotes on
T5034 10587-10593 VB denotes peaked
T5033 10585-10586 -COMMA- denotes ,
T5032 10584-10585 -RRB- denotes )
T5031 10581-10584 CD denotes .05
T5030 10579-10580 SYM denotes <
T5029 10577-10578 NN denotes P
T5028 10576-10577 -LRB- denotes (
T5027 10572-10575 NN denotes ICH
T4616 9993-9996 NN denotes day
T4615 9989-9992 JJ denotes 3rd
T4614 9985-9988 DT denotes the
T4613 9982-9984 IN denotes on
T4612 9975-9981 VB denotes peaked
T4611 9973-9974 -COMMA- denotes ,
T4610 9972-9973 -RRB- denotes )
T4609 9969-9972 CD denotes .05
T4608 9967-9968 SYM denotes <
T4607 9965-9966 NN denotes P
T4606 9964-9965 -LRB- denotes (
T4605 9960-9963 NN denotes ICH
T4604 9954-9959 IN denotes after
T4603 9946-9953 NN denotes 6 hours
T4602 9941-9945 IN denotes from
T4601 9932-9940 VB denotes starting
T4600 9922-9931 VB denotes increased
T4599 9908-9921 RB denotes significantly
T4598 9904-9907 NN denotes ICH
T4597 9898-9903 IN denotes after
T4596 9893-9897 NN denotes mRNA
T4595 9888-9892 NN denotes TLR4
T4594 9884-9887 DT denotes the
T4593 9882-9883 -COMMA- denotes ,
T4592 9875-9882 RB denotes However
T4591 9868-9873 NN denotes group
T4590 9861-9867 JJ denotes normal
T4589 9856-9860 IN denotes from
T4588 9846-9855 JJ denotes different
T4587 9832-9845 RB denotes significantly
T4586 9828-9831 RB denotes not
T4585 9824-9827 VB denotes was
T4584 9820-9823 CC denotes but
T4583 9818-9819 -COMMA- denotes ,
T4582 9809-9818 VB denotes increased
T4581 9800-9808 RB denotes slightly
T4580 9795-9799 NN denotes mRNA
T4579 9790-9794 NN denotes TLR4
T4578 9786-9789 DT denotes the
T4577 9784-9785 -COMMA- denotes ,
T4576 9779-9784 NN denotes group
T4575 9771-9778 NN denotes control
T4574 9764-9770 NN denotes saline
T4573 9760-9763 DT denotes the
T4572 9757-9759 IN denotes In
T4571 9749-9755 NN denotes tissue
T4570 9743-9748 NN denotes brain
T4569 9739-9742 NN denotes rat
T4568 9732-9738 JJ denotes normal
T4567 9729-9731 IN denotes in
T4566 9720-9728 VB denotes observed
T4565 9716-9719 VB denotes was
T4564 9711-9715 NN denotes mRNA
T4563 9706-9710 NN denotes TLR4
T4562 9703-9705 IN denotes of
T4561 9697-9702 NN denotes level
T4560 9693-9696 JJ denotes low
T4559 9689-9692 DT denotes The
T4558 9681-9687 NN denotes Rt-PCR
T4557 9678-9680 IN denotes by
T4556 9669-9677 VB denotes detected
T4555 9664-9668 VB denotes were
T4554 9657-9663 NN denotes levels
T4553 9652-9656 NN denotes mRNA
T4552 9647-9651 NN denotes TLR4
T4551 9643-9646 NN denotes ICH
T4550 9637-9642 IN denotes after
T4549 9630-9636 NN denotes Tissue
T4548 9624-9629 NNP denotes Brain
T4547 9621-9623 IN denotes in
T4546 9611-9620 VB denotes Increased
T4545 9606-9610 NN denotes mRNA
T4544 9601-9605 NN denotes TLR4
T4543 9596-9599 CD denotes 3.1
T5026 10566-10571 IN denotes after
T5025 10558-10565 NN denotes 6 hours
T5024 10553-10557 IN denotes from
T5023 10544-10552 VB denotes starting
T5022 10534-10543 VB denotes increased
T5021 10520-10533 RB denotes significantly
T5020 10515-10519 NN denotes TLR4
T5019 10512-10514 IN denotes of
T5018 10501-10511 NN denotes expression
T5017 10497-10500 DT denotes The
T5016 10490-10495 NN denotes group
T5015 10482-10489 NN denotes control
T5014 10475-10481 NN denotes saline
T5013 10471-10474 DT denotes the
T5012 10468-10470 IN denotes in
T5011 10457-10467 JJ denotes detectable
T5010 10453-10456 VB denotes was
T5009 10445-10452 NN denotes protein
T5008 10440-10444 NN denotes TLR4
T5007 10437-10439 IN denotes of
T5006 10431-10436 NN denotes level
T5005 10427-10430 JJ denotes low
T5004 10425-10426 DT denotes a
T5003 10420-10424 IN denotes that
T5002 10413-10419 VB denotes showed
T5001 10405-10412 NN denotes results
T5000 10401-10404 PRP-DOLLAR- denotes Our
T4999 10395-10399 NN denotes TLR4
T4998 10391-10394 IN denotes for
T4997 10380-10390 NN denotes antibodies
T4996 10371-10379 JJ denotes specific
T4995 10365-10370 VB denotes using
T4994 10359-10364 NN denotes Blots
T4993 10351-10358 JJ denotes Western
T4992 10348-10350 IN denotes of
T4991 10341-10347 NN denotes method
T4990 10337-10340 DT denotes the
T4989 10334-10336 IN denotes by
T4988 10327-10333 NN denotes tissue
T4987 10321-10326 NN denotes brain
T4986 10318-10320 IN denotes in
T4985 10309-10317 VB denotes measured
T4984 10305-10308 VB denotes was
T4983 10297-10304 NN denotes protein
T4982 10292-10296 NN denotes TLR4
T4981 10289-10291 IN denotes of
T4980 10278-10288 NN denotes expression
T4979 10274-10277 DT denotes the
T4978 10272-10273 -COMMA- denotes ,
T4977 10267-10272 NN denotes level
T4976 10259-10266 NN denotes protein
T4975 10255-10258 DT denotes the
T4974 10252-10254 IN denotes at
T4973 10247-10251 NN denotes TLR4
T4972 10237-10246 VB denotes increased
T4971 10233-10236 DT denotes the
T4970 10221-10232 VB denotes investigate
T4969 10218-10220 TO denotes To
T4968 10214-10217 NN denotes ICH
T4967 10208-10213 IN denotes after
T4966 10201-10207 NN denotes Tissue
T4965 10195-10200 NNP denotes Brain
T4964 10192-10194 IN denotes in
T4963 10182-10191 VB denotes Increased
T4962 10174-10181 NN denotes Protein
T4961 10169-10173 NN denotes TLR4
T4960 10166-10168 IN denotes of
T4959 10155-10165 NN denotes Expression
T4958 10150-10153 CD denotes 3.2
T4425 9569-9581 NN denotes significance
T4424 9566-9568 IN denotes of
T4423 9557-9565 NN denotes criteria
T4422 9553-9556 DT denotes the
T4421 9550-9552 IN denotes as
T4420 9545-9549 VB denotes used
T4419 9541-9544 VB denotes was
T4418 9529-9540 NN denotes probability
T4417 9526-9528 IN denotes of
T4416 9520-9525 NN denotes level
T4415 9516-9519 CD denotes .05
T4414 9514-9515 JJ denotes <
T4413 9512-9513 NN denotes P
T4412 9508-9511 DT denotes The
T4411 9500-9506 NN denotes t-test
T4410 9497-9499 POS denotes 's
T4409 9490-9497 NN denotes Student
T4408 9487-9489 CC denotes or
T4407 9485-9486 -RRB- denotes )
T4406 9480-9485 NN denotes ANOVA
T4405 9479-9480 -LRB- denotes (
T4404 9470-9478 NN denotes variance
T4403 9467-9469 IN denotes of
T4402 9458-9466 NN denotes analysis
T4401 9450-9457 JJ denotes one-way
T4399 9438-9446 VB denotes analyzed
T4398 9433-9437 VB denotes were
T4397 9420-9432 NN denotes measurements
T4396 9416-9419 DT denotes The
T4395 9411-9414 NN denotes SEM
T4394 9409-9410 NN denotes ±
T4393 9404-9408 JJ denotes mean
T4392 9401-9403 IN denotes as
T4391 9391-9400 VB denotes presented
T4390 9386-9390 VB denotes were
T4389 9381-9385 NN denotes data
T4388 9377-9380 DT denotes All
T4387 9368-9376 NN denotes Analysis
T4386 9356-9367 JJ denotes Statistical
T4385 9351-9354 CD denotes 2.7
T4652 10146-10147 -RRB- denotes )
T4651 10145-10146 CD denotes 1
T4650 10138-10144 NNP denotes Figure
T4649 10136-10137 -COMMA- denotes ,
T4648 10133-10136 CD denotes .05
T4647 10131-10132 JJ denotes <
T4646 10129-10130 NN denotes P
T4645 10128-10129 -LRB- denotes (
T4644 10120-10127 NN denotes control
T4643 10113-10119 NN denotes saline
T4642 10108-10112 IN denotes with
T4641 10099-10107 VB denotes compared
T4640 10093-10098 NN denotes level
T4639 10086-10092 JJ denotes higher
T4638 10084-10085 DT denotes a
T4637 10073-10083 VB denotes maintained
T4636 10067-10072 RB denotes still
T4635 10063-10066 CC denotes but
T4634 10061-10062 -COMMA- denotes ,
T4633 10060-10061 -RRB- denotes )
T4632 10057-10060 CD denotes .05
T4631 10055-10056 SYM denotes <
T4630 10053-10054 NN denotes P
T4629 10052-10053 -LRB- denotes (
T4628 10048-10051 NN denotes ICH
T4627 10042-10047 IN denotes after
T4626 10038-10041 NN denotes day
T4625 10034-10037 JJ denotes 7th
T4624 10030-10033 DT denotes the
T4623 10027-10029 IN denotes on
T4622 10017-10026 VB denotes decreased
T4621 10012-10016 RB denotes then
T4620 10008-10011 CC denotes and
T4619 10006-10007 -COMMA- denotes ,
T4618 10003-10006 NN denotes ICH
T4617 9997-10002 IN denotes after
T4046 8537-8541 IN denotes from
T4045 8528-8536 VB denotes isolated
T4044 8523-8527 VB denotes were
T4043 8514-8522 NN denotes proteins
T4042 8506-8513 JJ denotes Nuclear
T4041 8504-8505 -RRB- denotes )
T4040 8500-8504 NN denotes EMSA
T4039 8499-8500 -LRB- denotes (
T4038 8493-8498 NN denotes Assay
T4037 8487-8492 NN denotes Shift
T4036 8478-8486 NN denotes Mobility
T4035 8462-8477 JJ denotes Electrophoretic
T4034 8457-8460 CD denotes 2.6
T4400 9447-9449 IN denotes by
T3847 8446-8454 NN denotes analysis
T3846 8440-8445 NN denotes image
T3845 8422-8439 JJ denotes computer-assisted
T3844 8418-8421 CC denotes and
T3843 8405-8417 NN denotes densitometry
T3842 8396-8404 VB denotes scanning
T3841 8393-8395 IN denotes by
T3840 8382-8392 VB denotes quantified
T3839 8377-8381 VB denotes were
T3838 8369-8376 NN denotes signals
T3837 8365-8368 DT denotes The
T3836 8357-8363 NN denotes buffer
T3835 8347-8356 VB denotes stripping
T3834 8342-8346 IN denotes with
T3833 8335-8341 VB denotes washed
T3832 8329-8334 VB denotes being
T3831 8323-8328 IN denotes after
T3790 8053-8055 IN denotes by
T3789 8044-8052 VB denotes followed
T3788 8042-8043 -RRB- denotes )
T3787 8036-8042 NN denotes BA1717
T3786 8034-8035 -COMMA- denotes ,
T3785 8029-8034 NN denotes WuHan
T3784 8028-8029 -LRB- denotes (
T3783 8019-8027 NN denotes antibody
T3782 8011-8018 JJ denotes primary
T3781 7999-8010 JJ denotes appropriate
T3780 7995-7998 DT denotes the
T3779 7990-7994 IN denotes with
T3778 7980-7989 VB denotes incubated
T3777 7975-7979 VB denotes were
T3776 7965-7974 NN denotes membranes
T3775 7961-7964 NN denotes ECL
T3774 7957-7960 DT denotes The
T3773 7954-7955 -RRB- denotes )
T3772 7952-7954 NNP denotes NJ
T3771 7950-7951 -COMMA- denotes ,
T3770 7940-7950 NNP denotes Piscataway
T3769 7938-7939 -COMMA- denotes ,
T3768 7929-7938 NNP denotes Pharmacia
T3767 7920-7928 NNP denotes Amersham
T3766 7919-7920 -LRB- denotes (
T3765 7909-7918 NN denotes membranes
T3764 7905-7908 NN denotes ECL
T3763 7898-7904 NNP denotes Hybond
T3762 7893-7897 IN denotes onto
T3761 7881-7892 VB denotes transferred
T3760 7877-7880 CC denotes and
T3759 7873-7876 NN denotes gel
T3758 7854-7872 NN denotes SDS-polyacrylamide
T3757 7849-7853 IN denotes with
T3756 7833-7848 VB denotes electrophoresed
T3755 7831-7832 -COMMA- denotes ,
T3754 7820-7831 NN denotes hemispheres
T3753 7811-7819 JJ denotes cerebral
T3752 7807-7810 NN denotes ICH
T3751 7802-7806 IN denotes from
T3750 7793-7801 VB denotes prepared
T3749 7788-7792 VB denotes were
T3748 7779-7787 NN denotes proteins
T3747 7770-7778 JJ denotes Cellular
T3746 7764-7769 NN denotes Blots
T3745 7756-7763 JJ denotes Western
T3744 7751-7754 CD denotes 2.5
T4180 9339-9348 VB denotes described
T4179 9328-9338 RB denotes previously
T4178 9325-9327 IN denotes as
T4177 9313-9324 NN denotes specificity
T4176 9305-9312 NN denotes binding
T4175 9300-9304 NN denotes NFκB
T4174 9292-9299 VB denotes confirm
T4173 9289-9291 TO denotes to
T4172 9279-9288 VB denotes performed
T4171 9275-9278 VB denotes was
T4170 9271-9274 NN denotes P50
T4169 9267-9270 CC denotes and
T4168 9263-9266 NN denotes P65
T4167 9260-9262 TO denotes to
T4166 9249-9259 NN denotes antibodies
T4165 9243-9248 VB denotes using
T4164 9237-9242 NN denotes assay
T4163 9231-9236 NN denotes shift
T4162 9225-9230 JJ denotes super
T4161 9223-9224 DT denotes A
T4160 9206-9221 NN denotes oligonucleotide
T4159 9196-9205 NN denotes consensus
T4158 9191-9195 NN denotes NFκB
T4157 9175-9190 JJ denotes double-stranded
T4156 9167-9174 VB denotes labeled
T4155 9165-9166 -RRB- denotes ]
T4154 9160-9165 NN denotes γ-32P
T4153 9159-9160 -LRB- denotes [
T4152 9151-9158 NN denotes 35 fmol
T4151 9147-9150 CC denotes and
T4150 9138-9146 NN denotes proteins
T4149 9130-9137 JJ denotes nuclear
T4148 9127-9129 IN denotes of
T4147 9121-9126 NN denotes 15 μg
T4146 9110-9120 VB denotes containing
T4145 9102-9109 NN denotes mixture
T4144 9093-9101 NN denotes reaction
T4143 9085-9092 NN denotes binding
T4142 9079-9084 NN denotes 15 μL
T4141 9077-9078 DT denotes a
T4140 9074-9076 IN denotes in
T4139 9065-9073 VB denotes examined
T4138 9061-9064 VB denotes was
T4137 9052-9060 NN denotes activity
T4136 9044-9051 NN denotes binding
T4135 9039-9043 NN denotes NFκB
T4134 9036-9037 -RRB- denotes ]
T4133 9035-9036 CD denotes 8
T4132 9034-9035 -LRB- denotes [
T4131 9023-9033 RB denotes previously
T4130 9013-9022 VB denotes described
T4129 9010-9012 IN denotes as
T4128 9000-9009 VB denotes performed
T4127 8996-8999 VB denotes was
T4126 8991-8995 NN denotes EMSA
T4125 8986-8989 NN denotes use
T4124 8980-8985 IN denotes until
T4123 8974-8979 NN denotes −80°C
T4122 8971-8973 IN denotes at
T4121 8964-8970 VB denotes stored
T4120 8960-8963 CC denotes and
T4119 8955-8959 NN denotes tube
T4118 8944-8954 JJ denotes prechilled
T4117 8938-8943 JJ denotes clean
T4116 8936-8937 DT denotes a
T4115 8933-8935 TO denotes to
T4114 8921-8932 VB denotes transferred
T4113 8916-8920 VB denotes were
T4112 8914-8915 -RRB- denotes )
T4111 8907-8914 NN denotes extract
T4110 8899-8906 JJ denotes nuclear
T4109 8898-8899 -LRB- denotes (
T4108 8885-8897 NN denotes supernatants
T4107 8881-8884 DT denotes The
T4106 8872-8879 NN denotes minutes
T4105 8869-8871 CD denotes 10
T4104 8865-8868 IN denotes for
T4103 8854-8864 NN denotes centrifuge
T4102 8848-8853 NN denotes micro
T4101 8846-8847 DT denotes a
T4100 8843-8845 IN denotes in
T4099 8841-8842 -RRB- denotes )
T4098 8838-8841 NN denotes × g
T4097 8830-8837 CD denotes ~16,000
T4096 8829-8830 -LRB- denotes (
T4095 8823-8828 NN denotes speed
T4094 8815-8822 JJ denotes maximum
T4093 8812-8814 IN denotes at
T4092 8800-8811 VB denotes centrifuged
T4091 8795-8799 VB denotes were
T4090 8789-8794 NN denotes tubes
T4089 8785-8788 DT denotes The
T4088 8776-8783 NN denotes minutes
T4087 8773-8775 CD denotes 40
T4086 8770-8772 IN denotes of
T4085 8764-8769 NN denotes total
T4084 8762-8763 DT denotes a
T4083 8758-8761 IN denotes for
T4082 8756-8757 -COMMA- denotes ,
T4081 8749-8756 NN denotes minutes
T4080 8746-8748 CD denotes 10
T4079 8740-8745 DT denotes every
T4078 8732-8739 NN denotes seconds
T4077 8729-8731 CD denotes 15
T4076 8725-8728 IN denotes for
T4075 8718-8724 NN denotes vortex
T4074 8715-8717 IN denotes on
T4073 8711-8714 VB denotes put
T4072 8706-8710 VB denotes were
T4071 8698-8705 NN denotes pellets
T4070 8687-8697 VB denotes containing
T4069 8681-8686 NN denotes tubes
T4068 8677-8680 DT denotes The
T4067 8668-8675 NN denotes reagent
T4066 8657-8667 NN denotes extraction
T4065 8649-8656 JJ denotes nuclear
T4064 8646-8648 IN denotes in
T4063 8634-8645 VB denotes resuspended
T4062 8629-8633 VB denotes were
T4061 8621-8628 NN denotes pellets
T4060 8617-8620 DT denotes the
T4059 8615-8616 -COMMA- denotes ,
T4058 8614-8615 -RRB- denotes )
T4057 8607-8614 NN denotes extract
T4056 8595-8606 JJ denotes cytoplasmic
T4055 8594-8595 -LRB- denotes (
T4054 8582-8593 NN denotes supernatant
T4053 8579-8581 IN denotes of
T4052 8571-8578 NN denotes removal
T4051 8565-8570 IN denotes after
T4050 8563-8564 -COMMA- denotes ,
T4049 8556-8563 RB denotes Briefly
T4048 8548-8554 NN denotes tissue
T4047 8542-8547 NN denotes brain
T3605 7740-7748 NN denotes controls
T3604 7731-7739 JJ denotes negative
T3603 7728-7730 IN denotes as
T3602 7721-7727 VB denotes served
T3601 7710-7720 NN denotes antibodies
T3600 7702-7709 JJ denotes primary
T3599 7694-7701 IN denotes without
T3598 7684-7693 VB denotes processed
T3597 7677-7683 NN denotes Slides
T3596 7674-7675 -RRB- denotes )
T3595 7672-7674 NNP denotes CA
T3594 7670-7671 -COMMA- denotes ,
T3593 7666-7670 NNP denotes Cruz
T3592 7660-7665 NNP denotes Santa
T3591 7659-7660 -LRB- denotes (
T3590 7654-7658 NNP denotes Inc.
T3589 7640-7653 NNP denotes Biotechnology
T3588 7635-7639 NNP denotes Cruz
T3587 7629-7634 NNP denotes Santa
T3586 7624-7628 IN denotes from
T3585 7615-7623 VB denotes obtained
T3584 7610-7614 VB denotes were
T3583 7608-7609 -RRB- denotes )
T3582 7601-7608 NN denotes SC-2018
T3581 7599-7600 -COMMA- denotes ,
T3580 7592-7599 NN denotes reagent
T3579 7588-7591 NN denotes ABC
T3578 7587-7588 -LRB- denotes (
T3577 7577-7586 NN denotes complexes
T3576 7543-7576 JJ denotes antibody-biotin-avidin-peroxidase
T3575 7539-7542 CC denotes and
T3830 8321-8322 -RRB- denotes )
T3829 8316-8321 NNP denotes Maine
T3828 8314-8315 -COMMA- denotes ,
T3827 8310-8314 NNP denotes Saco
T3826 8308-8309 -COMMA- denotes ,
T3825 8299-8308 NNP denotes Biodesign
T3824 8297-8298 -COMMA- denotes ,
T3823 8284-8297 NN denotes dehydrogenase
T3822 8257-8283 NN denotes glyceraldehyde-3-phosphate
T3821 8256-8257 -LRB- denotes (
T3820 8245-8255 NN denotes anti-GAPDH
T3819 8240-8244 IN denotes with
T3818 8233-8239 VB denotes probed
T3817 8228-8232 VB denotes were
T3816 8218-8227 NN denotes membranes
T3815 8213-8217 JJ denotes same
T3814 8209-8212 DT denotes The
T3813 8206-8207 -RRB- denotes )
T3812 8197-8206 NNP denotes Pharmacia
T3811 8188-8196 NNP denotes Amersham
T3810 8187-8188 -LRB- denotes (
T3809 8180-8186 NN denotes system
T3808 8176-8179 NN denotes ECL
T3807 8172-8175 DT denotes the
T3806 8167-8171 IN denotes with
T3805 8158-8166 VB denotes detected
T3804 8153-8157 VB denotes were
T3803 8145-8152 NN denotes signals
T3802 8141-8144 DT denotes The
T3801 8138-8139 -RRB- denotes )
T3800 8131-8138 NN denotes PV-6001
T3799 8129-8130 -COMMA- denotes ,
T3798 8123-8129 NNP denotes Bridge
T3797 8116-8122 NNP denotes Golden
T3796 8115-8116 -LRB- denotes (
T3795 8104-8114 NN denotes antibodies
T3794 8094-8103 JJ denotes secondary
T3793 8072-8093 JJ denotes peroxidase-conjugated
T3792 8067-8071 IN denotes with
T3791 8056-8066 NN denotes incubation
T3068 7327-7331 NN denotes mRNA
T3067 7319-7326 NN denotes β-actin
T3066 7316-7318 TO denotes to
T3065 7311-7315 NN denotes mRNA
T3064 7306-7310 NN denotes TLR4
T3063 7303-7305 IN denotes of
T3062 7297-7302 NN denotes ratio
T3061 7293-7296 DT denotes the
T3060 7290-7292 IN denotes as
T3059 7280-7289 VB denotes expressed
T3058 7276-7279 VB denotes was
T3057 7271-7275 NN denotes mRNA
T3056 7266-7270 NN denotes TLR4
T3055 7263-7265 IN denotes of
T3054 7253-7262 NN denotes abundance
T3053 7249-7252 DT denotes The
T3052 7238-7247 NN denotes densities
T3051 7233-7237 NN denotes band
T3050 7223-7232 VB denotes determine
T3049 7220-7222 TO denotes to
T3048 7215-7219 VB denotes used
T3047 7210-7214 VB denotes were
T3046 7201-7209 NN denotes software
T3045 7192-7200 NN denotes Analysis
T3044 7188-7191 CC denotes and
T3043 7176-7187 NNP denotes Acquisition
T3042 7170-7175 NN denotes Image
T3041 7165-7168 NN denotes gel
T3040 7157-7164 NN denotes agarose
T3039 7149-7156 IN denotes through
T3038 7133-7148 VB denotes electrophoresed
T3037 7128-7132 VB denotes were
T3036 7119-7127 NN denotes products
T3035 7115-7118 NN denotes PCR
T3034 7107-7113 NN denotes cycles
T3033 7104-7106 CD denotes 31
T3032 7098-7103 IN denotes after
T3031 7090-7097 VB denotes stopped
T3030 7086-7089 VB denotes was
T3029 7077-7085 NN denotes reaction
T3028 7073-7076 DT denotes The
T3027 7067-7071 NN denotes 60 s
T3026 7062-7066 NN denotes 72°C
T3025 7058-7061 CC denotes and
T3024 7056-7057 -COMMA- denotes ,
T3023 7052-7056 NN denotes 40 s
T3022 7047-7051 NN denotes 55°C
T3021 7045-7046 -COMMA- denotes ,
T3020 7041-7045 NN denotes 40 s
T3019 7036-7040 NN denotes 94°C
T3018 7034-7035 -COMMA- denotes ,
T3017 7029-7034 NN denotes 2 min
T3016 7024-7028 NN denotes 94°C
T3015 7022-7023 -COLON- denotes :
T3014 7013-7022 NN denotes condition
T3013 7003-7012 VB denotes following
T3012 6999-7002 DT denotes the
T3011 6996-6998 IN denotes at
T3010 6986-6995 VB denotes performed
T3009 6981-6985 VB denotes were
T3008 6974-6980 NN denotes cycles
T3007 6965-6973 NN denotes Reaction
T3006 6938-6963 NN denotes 5′-CCAGGATAGAGCCACCAAT-3′
T3005 6936-6937 -COLON- denotes :
T3004 6929-6936 NN denotes reverse
T3003 6927-6928 -COLON- denotes ;
T3002 6902-6927 NN denotes 5′-GCCAACCGTGAAAAAGATG-3′
T3001 6900-6901 -COLON- denotes :
T3000 6893-6900 RB denotes forward
T2999 6891-6892 -COLON- denotes :
T2998 6890-6891 -RRB- denotes )
T2997 6884-6890 NN denotes 701 bp
T2996 6883-6884 -LRB- denotes (
T2995 6875-6882 NN denotes β-actin
T2994 6873-6874 -COLON- denotes ;
T2993 6847-6873 NN denotes 5′-CAGGATGACACCATTGAAGC-3′
T2992 6845-6846 -COLON- denotes :
T2991 6838-6845 NN denotes reverse
T2990 6836-6837 -COLON- denotes ;
T2989 6810-6836 NN denotes 5′-AGCTTTGGTCAGTTGGCTCT-3′
T2988 6808-6809 -COLON- denotes :
T2987 6801-6808 RB denotes forward
T2986 6799-6800 -COLON- denotes :
T2985 6798-6799 -RRB- denotes )
T2984 6792-6798 NN denotes 145 bp
T2983 6791-6792 -LRB- denotes (
T2982 6786-6790 NN denotes TLR4
T2981 6777-6784 NNP denotes GenBank
T2980 6774-6776 IN denotes in
T2979 6765-6773 VB denotes reported
T2978 6755-6764 NN denotes sequences
T2977 6750-6754 NN denotes gene
T2976 6742-6749 JJ denotes β-actin
T2975 6738-6741 CC denotes and
T2974 6733-6737 NN denotes TLR4
T2973 6729-6732 DT denotes the
T2972 6726-6728 TO denotes to
T2971 6716-6725 VB denotes according
T2970 6707-6715 VB denotes designed
T2969 6702-6706 VB denotes were
T2968 6692-6701 NN denotes sequences
T2967 6685-6691 NN denotes primer
T2966 6681-6684 NN denotes PCR
T2965 6677-6680 DT denotes The
T2964 6668-6675 NN denotes control
T2963 6659-6667 JJ denotes internal
T2962 6656-6658 DT denotes an
T2961 6653-6655 IN denotes as
T2960 6648-6652 VB denotes used
T2959 6644-6647 VB denotes was
T2958 6642-6643 -RRB- denotes )
T2957 6635-6642 NN denotes β-actin
T2956 6634-6635 -LRB- denotes (
T2955 6629-6633 NN denotes gene
T2954 6624-6628 NN denotes keep
T2953 6618-6623 NN denotes house
T2952 6614-6617 DT denotes The
T2951 6602-6612 NN denotes polymerase
T2950 6598-6601 NN denotes DNA
T2949 6594-6597 NN denotes Taq
T2948 6591-6593 NN denotes 2u
T2947 6587-6590 CC denotes and
T2946 6585-6586 -COMMA- denotes ,
T2945 6578-6585 NN denotes primers
T2944 6575-6577 IN denotes of
T2943 6568-6574 NN denotes 200 μM
T2942 6566-6567 -COMMA- denotes ,
T2941 6562-6566 NN denotes dNTP
T2940 6557-6561 DT denotes each
T2939 6554-6556 IN denotes of
T2938 6547-6553 NN denotes 200 μM
T2937 6545-6546 -COMMA- denotes ,
T2936 6533-6545 NN denotes 1.5 mM MgCl2
T2935 6531-6532 -COMMA- denotes ,
T2934 6525-6531 NN denotes buffer
T2933 6521-6524 NN denotes PCR
T2932 6518-6520 NN denotes 1×
T2931 6513-6517 IN denotes with
T2930 6504-6512 NN denotes fragment
T2929 6499-6503 NN denotes gene
T2928 6494-6498 NN denotes TLR4
T2927 6490-6493 DT denotes the
T2926 6482-6489 VB denotes amplify
T2925 6479-6481 TO denotes to
T3574 7530-7538 NN denotes antibody
T3573 7520-7529 JJ denotes secondary
T3572 7507-7519 VB denotes biotinylated
T3571 7503-7506 DT denotes The
T3570 7500-7501 -RRB- denotes )
T3569 7494-7500 NN denotes BA1717
T3568 7492-7493 -COMMA- denotes ,
T3567 7487-7492 NNP denotes WuHan
T3566 7486-7487 -LRB- denotes (
T3565 7476-7485 NN denotes anti-TLR4
T3564 7469-7475 NN denotes rabbit
T3563 7465-7468 VB denotes was
T3562 7456-7464 VB denotes employed
T3561 7447-7455 NN denotes antibody
T3560 7439-7446 JJ denotes primary
T3559 7435-7438 DT denotes The
T3558 7432-7433 -RRB- denotes ]
T3557 7431-7432 CD denotes 8
T3556 7430-7431 -LRB- denotes [
T3555 7419-7429 RB denotes previously
T3554 7409-7418 VB denotes described
T3553 7406-7408 IN denotes as
T3552 7396-7405 VB denotes performed
T3551 7392-7395 VB denotes was
T3550 7387-7391 NN denotes TLR4
T3549 7383-7386 IN denotes for
T3548 7374-7382 NN denotes staining
T3547 7370-7373 NN denotes IHC
T3546 7366-7369 DT denotes The
T3545 7364-7365 -RRB- denotes )
T3544 7361-7364 NN denotes IHC
T3543 7360-7361 -LRB- denotes (
T3542 7339-7359 NN denotes Immunohistochemistry
T3541 7334-7337 CD denotes 2.4
T2924 6474-6478 VB denotes used
T2923 6470-6473 VB denotes was
T2922 6465-6469 NN denotes cDNA
T2921 6462-6464 IN denotes of
T2920 6451-6461 NN denotes microliter
T2919 6447-6450 CD denotes One
T2918 6437-6445 NN denotes supplier
T2917 6433-6436 DT denotes the
T2916 6430-6432 IN denotes by
T2915 6420-6429 VB denotes described
T2914 6409-6419 NN denotes conditions
T2913 6403-6408 IN denotes under
T2912 6401-6402 -RRB- denotes )
T2911 6398-6401 NNP denotes Inc
T2910 6390-6397 JJ denotes promega
T2909 6389-6390 -LRB- denotes (
T2908 6382-6388 NN denotes RT-PCR
T2907 6378-6381 IN denotes for
T2906 6374-6377 NN denotes Kit
T2905 6364-6373 NNP denotes Synthesis
T2904 6351-6363 NNP denotes First-Strand
T2903 6339-6350 NNP denotes Superscript
T2902 6333-6338 VB denotes using
T2901 6326-6332 NN denotes system
T2900 6317-6325 NN denotes reaction
T2899 6311-6316 NN denotes 20 μL
T2898 6308-6310 IN denotes in
T2897 6303-6307 NN denotes cDNA
T2896 6298-6302 IN denotes into
T2895 6278-6297 VB denotes reverse-transcribed
T2894 6274-6277 VB denotes was
T2893 6270-6273 NN denotes RNA
T2892 6260-6268 NN denotes 1.0 g/mL
T2891 6257-6259 TO denotes to
T2890 6248-6256 VB denotes adjusted
T2889 6243-6247 VB denotes were
T2888 6238-6242 NN denotes mRNA
T2887 6235-6237 IN denotes of
T2886 6220-6234 NN denotes concentrations
T2885 6216-6219 DT denotes the
T2884 6214-6215 -COMMA- denotes ,
T2883 6210-6214 RB denotes Then
T2882 6198-6208 NN denotes wavelength
T2881 6190-6197 NN denotes A280 nm
T2880 6186-6189 CC denotes and
T2879 6181-6185 NN denotes A260
T2878 6178-6180 IN denotes at
T2877 6170-6177 NN denotes density
T2876 6162-6169 JJ denotes optical
T2875 6152-6161 VB denotes measuring
T2874 6149-6151 IN denotes by
T2873 6147-6148 -RRB- denotes )
T2448 5805-5813 VB denotes injected
T2447 5801-5804 VB denotes was
T2446 5794-5800 NN denotes saline
T2445 5787-5793 JJ denotes normal
T2444 5781-5786 NN denotes 75 μL
T2443 5776-5780 RB denotes only
T2442 5774-5775 -COMMA- denotes ,
T2441 5770-5774 NN denotes rats
T2440 5762-5769 NN denotes control
T2439 5755-5761 NN denotes saline
T2438 5748-5754 JJ denotes normal
T2437 5744-5747 DT denotes the
T2436 5740-5743 IN denotes For
T2435 5731-5738 NN denotes sutures
T2434 5726-5730 IN denotes with
T2433 5719-5725 VB denotes closed
T2432 5715-5718 VB denotes was
T2431 5706-5714 NN denotes incision
T2430 5701-5705 NN denotes skin
T2429 5697-5700 DT denotes the
T2428 5693-5696 CC denotes and
T2427 5691-5692 -COMMA- denotes ,
T2426 5687-5691 NN denotes hole
T2425 5682-5686 NN denotes burr
T2424 5678-5681 DT denotes the
T2423 5671-5677 IN denotes around
T2422 5664-5670 VB denotes placed
T2421 5660-5663 VB denotes was
T2420 5655-5659 NN denotes glue
T2419 5641-5654 NN denotes cyanoacrylate
T2418 5639-5640 -COMMA- denotes ,
T2417 5632-5639 RB denotes quickly
T2416 5622-5631 VB denotes withdrawn
T2415 5618-5621 VB denotes was
T2414 5611-5617 NN denotes needle
T2413 5607-5610 DT denotes the
T2412 5605-5606 -COMMA- denotes ,
T2411 5597-5605 NN denotes infusion
T2410 5593-5596 DT denotes the
T2409 5590-5592 IN denotes of
T2408 5579-5589 NN denotes completion
T2407 5575-5578 DT denotes the
T2406 5569-5574 IN denotes After
T2405 5563-5567 NN denotes pump
T2404 5549-5562 NN denotes microinfusion
T2403 5547-5548 DT denotes a
T2402 5544-5546 IN denotes of
T2401 5540-5543 NN denotes use
T2400 5536-5539 DT denotes the
T2399 5531-5535 IN denotes with
T2398 5521-5530 NN denotes 20 μL/min
T2397 5518-5520 IN denotes of
T2396 5513-5517 NN denotes rate
T2395 5511-5512 DT denotes a
T2394 5508-5510 IN denotes at
T2393 5500-5507 VB denotes infused
T2392 5496-5499 VB denotes was
T2391 5490-5495 NN denotes blood
T2390 5484-5489 JJ denotes whole
T2389 5473-5483 JJ denotes autologous
T2388 5470-5472 IN denotes of
T2387 5464-5469 NN denotes 75 μL
T2386 5462-5463 DT denotes a
T2385 5460-5461 -COMMA- denotes ,
T2384 5456-5460 RB denotes Then
T2383 5453-5454 -RRB- denotes )
T2382 5446-5453 NN denotes midline
T2381 5442-5445 DT denotes the
T2380 5439-5441 TO denotes to
T2379 5431-5438 JJ denotes lateral
T2378 5424-5430 NN denotes 3.0 mm
T2377 5420-5423 CC denotes and
T2376 5418-5419 -COMMA- denotes ,
T2375 5411-5418 JJ denotes ventral
T2374 5404-5410 NN denotes 6.0 mm
T2373 5402-5403 -COMMA- denotes ,
T2372 5394-5402 JJ denotes anterior
T2371 5387-5393 CD denotes 0.2 mm
T2370 5385-5386 -COLON- denotes :
T2369 5374-5385 NN denotes coordinates
T2368 5373-5374 -LRB- denotes (
T2367 5364-5372 NN denotes guidance
T2366 5351-5363 JJ denotes stereotactic
T2365 5345-5350 IN denotes under
T2364 5337-5344 NN denotes ganglia
T2363 5331-5336 JJ denotes basal
T2362 5326-5330 JJ denotes left
T2361 5322-5325 DT denotes the
T2360 5317-5321 IN denotes into
T2359 5308-5316 VB denotes inserted
T2358 5304-5307 VB denotes was
T2357 5297-5303 NN denotes needle
T2356 5288-5296 JJ denotes 26-gauge
T2355 5282-5287 JJ denotes blunt
T2354 5280-5281 DT denotes A
T2353 5271-5278 NN denotes midline
T2352 5267-5270 DT denotes the
T2351 5264-5266 TO denotes to
T2350 5256-5263 JJ denotes lateral
T2349 5251-5255 NN denotes 3 mm
T2348 5244-5250 NN denotes suture
T2347 5236-5243 JJ denotes coronal
T2346 5231-5235 JJ denotes left
T2345 5227-5230 DT denotes the
T2344 5224-5226 IN denotes on
T2343 5218-5223 NN denotes skull
T2342 5214-5217 DT denotes the
T2341 5211-5213 IN denotes in
T2340 5204-5210 VB denotes opened
T2339 5200-5203 VB denotes was
T2338 5195-5199 NN denotes hole
T2337 5190-5194 NN denotes burr
T2336 5185-5189 NN denotes 1 mm
T2335 5183-5184 DT denotes a
T2334 5181-5182 -COMMA- denotes ,
T2333 5172-5181 NN denotes technique
T2332 5164-5171 JJ denotes sterile
T2331 5162-5163 DT denotes a
T2330 5156-5161 VB denotes Using
T2329 5147-5154 NN denotes midline
T2328 5143-5146 DT denotes the
T2327 5137-5142 IN denotes along
T2326 5129-5136 VB denotes incised
T2325 5125-5128 VB denotes was
T2324 5119-5124 NN denotes scalp
T2323 5115-5118 DT denotes the
T2322 5111-5114 CC denotes and
T2321 5109-5110 -COMMA- denotes ,
T2320 5104-5109 NN denotes frame
T2297 4954-4955 -LRB- denotes (
T2296 4949-4953 NN denotes body
T2295 4945-4948 DT denotes The
T2294 4942-4943 -RRB- denotes )
T2293 4934-4942 NN denotes 60 mg/kg
T2292 4933-4934 -LRB- denotes (
T2291 4919-4932 NN denotes pentobarbital
T2290 4912-4918 NN denotes sodium
T2289 4895-4911 JJ denotes intra-peritoneal
T2288 4890-4894 IN denotes with
T2287 4877-4889 VB denotes anesthetized
T2286 4872-4876 VB denotes were
T2285 4867-4871 NN denotes Rats
T2284 4858-4865 NN denotes ganglia
T2283 4852-4857 JJ denotes basal
T2282 4847-4851 JJ denotes left
T2281 4844-4846 IN denotes in
T2280 4836-4843 VB denotes induced
T2279 4832-4835 VB denotes was
T2278 4828-4831 NN denotes ICH
T2277 4825-4827 IN denotes of
T2276 4819-4824 NN denotes model
T2275 4815-4818 NN denotes rat
T2274 4813-4814 -COMMA- denotes ,
T2273 4808-4813 NN denotes study
T2272 4800-4807 JJ denotes present
T2271 4796-4799 DT denotes the
T2270 4793-4795 IN denotes in
T2269 4791-4792 -COMMA- denotes ,
T2268 4781-4791 RB denotes clinically
T2267 4773-4780 NN denotes ganglia
T2266 4767-4772 JJ denotes basal
T2265 4763-4766 DT denotes the
T2264 4760-4762 IN denotes in
T2263 4754-4759 VB denotes occur
T2262 4742-4753 NN denotes hemorrhages
T2261 4728-4741 JJ denotes intracerebral
T2260 4723-4727 JJ denotes most
T2259 4717-4722 IN denotes Since
T2258 4706-4716 NNP denotes Hemorrhage
T2257 4692-4705 JJ denotes Intracerebral
T2256 4689-4691 IN denotes of
T2255 4679-4688 NN denotes Induction
T2254 4674-4677 CD denotes 2.2
T2872 6130-6147 NN denotes Spectrophotometer
T2871 6122-6129 NN denotes ND-1000
T2870 6121-6122 -LRB- denotes (
T2869 6112-6120 NNP denotes Nanodrop
T2868 6110-6111 DT denotes a
T2867 6107-6109 IN denotes on
T2866 6096-6106 VB denotes determined
T2865 6092-6095 VB denotes was
T2864 6088-6091 NN denotes RNA
T2863 6082-6087 JJ denotes total
T2862 6079-6081 IN denotes of
T2861 6070-6078 NN denotes quantity
T2860 6066-6069 DT denotes The
T2859 6052-6064 NN denotes instructions
T2858 6049-6051 POS denotes 's
T2857 6037-6049 NN denotes manufacturer
T2856 6033-6036 DT denotes the
T2855 6030-6032 TO denotes to
T2854 6020-6029 VB denotes according
T2853 6018-6019 -RRB- denotes )
T2852 6013-6018 NNP denotes China
T2851 6011-6012 -COMMA- denotes ,
T2850 6009-6011 NNP denotes HZ
T2849 6007-6008 -COMMA- denotes ,
T2848 6000-6007 NNP denotes BioFlux
T2847 5999-6000 -LRB- denotes (
T2846 5995-5998 NN denotes Kit
T2845 5985-5994 NN denotes isolation
T2844 5981-5984 NN denotes RNA
T2843 5975-5980 NNP denotes Total
T2842 5973-5974 NNP denotes P
T2841 5966-5972 NNP denotes Simply
T2840 5960-5965 VB denotes using
T2839 5952-5959 NN denotes ganglia
T2838 5946-5951 JJ denotes basal
T2837 5941-5945 JJ denotes left
T2836 5938-5940 IN denotes in
T2835 5930-5937 NN denotes regions
T2834 5914-5929 JJ denotes peri-hemorrhage
T2833 5909-5913 IN denotes from
T2832 5900-5908 VB denotes isolated
T2831 5895-5899 VB denotes were
T2830 5887-5894 NN denotes samples
T2829 5883-5886 NN denotes RNA
T2828 5877-5882 JJ denotes total
T2827 5875-5876 -COMMA- denotes ,
T2826 5868-5875 RB denotes Briefly
T2825 5861-5867 NN denotes RT-PCR
T2824 5858-5860 IN denotes of
T2823 5851-5857 NN denotes Method
T2822 5847-5850 DT denotes the
T2821 5844-5846 IN denotes by
T2820 5839-5843 NN denotes mRNA
T2819 5834-5838 NN denotes TLR4
T2818 5831-5833 IN denotes of
T2817 5821-5830 NN denotes Detection
T2816 5816-5819 CD denotes 2.3
T1988 4666-4671 NN denotes Blots
T1987 4658-4665 JJ denotes Western
T1986 4654-4657 CC denotes and
T1985 4647-4653 NN denotes RT-PCR
T1984 4643-4646 IN denotes for
T1983 4638-4642 NN denotes 80°C
T1982 4632-4637 CC denotes minus
T1981 4629-4631 IN denotes at
T1980 4622-4628 VB denotes stored
T1979 4618-4621 CC denotes and
T1978 4610-4617 VB denotes removed
T1977 4605-4609 VB denotes were
T1976 4598-4604 NN denotes brains
T1975 4594-4597 DT denotes The
T1974 4584-4593 NNP denotes Ketamine.
T1973 4581-4583 IN denotes of
T1972 4571-4580 NN denotes injection
T1971 4566-4570 NN denotes dose
T1970 4561-4565 IN denotes over
T1969 4558-4560 IN denotes by
T1968 4547-4557 VB denotes sacrificed
T1967 4542-4546 VB denotes were
T1966 4536-4541 NN denotes point
T1965 4531-4535 NN denotes time
T1964 4526-4530 DT denotes each
T1963 4523-4525 IN denotes at
T1962 4517-4522 NN denotes group
T1961 4512-4516 DT denotes each
T1960 4509-4511 IN denotes in
T1959 4504-4508 NN denotes rats
T1958 4499-4503 CD denotes Five
T1957 4496-4497 -RRB- denotes ]
T1956 4495-4496 CD denotes 8
T1955 4494-4495 -LRB- denotes [
T1954 4483-4493 RB denotes previously
T1953 4473-4482 VB denotes described
T1952 4470-4472 IN denotes as
T1951 4468-4469 -RRB- denotes )
T1950 4464-4468 NN denotes 7 μm
T1949 4463-4464 -LRB- denotes (
T1948 4454-4462 NN denotes sections
T1947 4449-4453 IN denotes into
T1946 4445-4448 VB denotes cut
T1945 4441-4444 CC denotes and
T1944 4439-4440 -COMMA- denotes ,
T1943 4431-4439 NN denotes paraffin
T1942 4428-4430 IN denotes in
T1941 4419-4427 VB denotes embedded
T1940 4417-4418 -COMMA- denotes ,
T1939 4408-4417 VB denotes postfixed
T1938 4406-4407 -COMMA- denotes ,
T1937 4399-4406 VB denotes removed
T1936 4394-4398 VB denotes were
T1935 4387-4393 NN denotes brains
T1934 4383-4386 DT denotes The
T1933 4380-4381 -RRB- denotes )
T1932 4377-4380 CD denotes 7.4
T1931 4375-4376 SYM denotes =
T1930 4372-4374 NN denotes pH
T1929 4371-4372 -LRB- denotes (
T1928 4358-4370 NN denotes formaldehyde
T1927 4353-4357 NNP denotes Para
T1926 4344-4352 VB denotes buffered
T1925 4342-4343 NN denotes %
T1924 4341-4342 CD denotes 4
T1923 4338-4340 IN denotes by
T1922 4329-4337 VB denotes followed
T1921 4322-4328 NN denotes saline
T1920 4315-4321 JJ denotes normal
T1919 4312-4314 IN denotes of
T1918 4302-4311 NN denotes perfusion
T1917 4287-4301 RB denotes transcardially
T1916 4284-4286 IN denotes by
T1915 4273-4283 VB denotes sacrificed
T1914 4268-4272 VB denotes were
T1913 4262-4267 NN denotes point
T1912 4257-4261 NN denotes time
T1911 4252-4256 DT denotes each
T1910 4249-4251 IN denotes at
T1909 4243-4248 NN denotes group
T1908 4238-4242 DT denotes each
T1907 4235-4237 IN denotes in
T1906 4230-4234 NN denotes rats
T1905 4225-4229 CD denotes Five
T1904 4211-4223 RB denotes respectively
T1903 4209-4210 -COMMA- denotes ,
T1902 4200-4209 NN denotes injection
T1901 4196-4199 DT denotes the
T1900 4190-4195 IN denotes after
T1899 4185-4189 NN denotes days
T1898 4183-4184 CD denotes 7
T1897 4179-4182 CC denotes and
T1896 4174-4178 NN denotes days
T1895 4172-4173 CD denotes 3
T1894 4170-4171 -COMMA- denotes ,
T1893 4167-4170 NN denotes day
T1892 4165-4166 CD denotes 1
T1891 4163-4164 -COMMA- denotes ,
T1890 4156-4163 NN denotes 6 hours
T1889 4153-4155 IN denotes on
T1888 4142-4152 VB denotes sacrificed
T1887 4137-4141 VB denotes were
T1886 4133-4136 CC denotes and
T1885 4127-4132 NN denotes blood
T1884 4121-4126 JJ denotes whole
T1883 4110-4120 JJ denotes autologous
T1882 4107-4109 CC denotes or
T1881 4100-4106 NN denotes saline
T1880 4093-4099 JJ denotes normal
T1879 4090-4092 IN denotes of
T1878 4080-4089 NN denotes injection
T1877 4065-4079 JJ denotes intra-cerebral
T1876 4062-4064 TO denotes to
T1875 4052-4061 VB denotes subjected
T1874 4047-4051 VB denotes were
T1873 4042-4046 NN denotes rats
T1872 4038-4041 DT denotes The
T1871 4026-4037 NNP denotes University.
T1870 4018-4025 NNP denotes Medical
T1869 4012-4017 NNP denotes China
T1868 4010-4011 -COMMA- denotes ,
T1867 4001-4010 NNP denotes Committee
T1866 3997-4000 NNP denotes Use
T1865 3993-3996 CC denotes and
T1864 3988-3992 NNP denotes Care
T1863 3981-3987 NNP denotes Animal
T1862 3977-3980 DT denotes the
T1861 3974-3976 IN denotes by
T1860 3965-3973 VB denotes approved
T1859 3961-3964 VB denotes was
T1858 3953-3960 NN denotes animals
T1857 3949-3952 IN denotes for
T1856 3944-3948 VB denotes used
T1855 3935-3943 NN denotes protocol
T1854 3922-3934 JJ denotes experimental
T1853 3918-3921 DT denotes The
T1852 3915-3916 -RRB- denotes )
T1851 3913-3915 CD denotes 40
T1850 3911-3912 SYM denotes =
T1849 3909-3910 NN denotes n
T1848 3907-3908 -COMMA- denotes ,
T1847 3904-3907 NN denotes ICH
T2319 5091-5103 JJ denotes stereotactic
T2318 5089-5090 DT denotes a
T2317 5086-5088 IN denotes in
T2316 5075-5085 VB denotes positioned
T2315 5070-5074 VB denotes were
T2314 5065-5069 NN denotes rats
T2313 5061-5064 DT denotes The
T2312 5053-5059 NN denotes system
T2311 5045-5052 NN denotes heating
T2310 5025-5044 JJ denotes feedback-controlled
T2309 5023-5024 DT denotes a
T2308 5017-5022 VB denotes using
T2307 5009-5016 NN denotes surgery
T2306 5005-5008 DT denotes the
T2305 4998-5004 IN denotes during
T2304 4993-4997 NN denotes 37°C
T2303 4990-4992 IN denotes at
T2302 4979-4989 VB denotes maintained
T2301 4975-4978 VB denotes was
T2300 4963-4974 NN denotes temperature
T2299 4961-4962 -RRB- denotes )
T2298 4955-4961 JJ denotes rectal
T1846 3903-3904 -LRB- denotes (
T1845 3897-3902 NN denotes group
T1844 3886-3896 NN denotes hemorrhage
T1843 3871-3885 JJ denotes intra-cerebral
T1842 3867-3870 CC denotes and
T1841 3865-3866 -RRB- denotes )
T1840 3858-3865 NN denotes control
T1839 3855-3857 IN denotes as
T1838 3848-3854 NN denotes saline
T1837 3841-3847 JJ denotes normal
T1836 3838-3840 IN denotes of
T1835 3828-3837 NN denotes injection
T1834 3813-3827 JJ denotes intra-cerebral
T1833 3811-3812 -COMMA- denotes ,
T1832 3809-3811 CD denotes 40
T1831 3807-3808 SYM denotes =
T1830 3805-3806 NN denotes n
T1829 3803-3804 -COMMA- denotes ,
T1828 3802-3803 NN denotes S
T1827 3801-3802 -LRB- denotes (
T1826 3793-3800 NN denotes control
T1825 3786-3792 NN denotes saline
T1824 3779-3785 JJ denotes normal
T1823 3777-3778 -COMMA- denotes ,
T1822 3776-3777 -RRB- denotes )
T1821 3767-3776 NN denotes treatment
T1820 3763-3766 DT denotes any
T1819 3755-3762 IN denotes without
T1818 3753-3754 -COMMA- denotes ,
T1817 3751-3753 CD denotes 10
T1816 3749-3750 SYM denotes =
T1815 3747-3748 NN denotes n
T1814 3745-3746 -COMMA- denotes ,
T1813 3744-3745 NN denotes N
T1812 3743-3744 -LRB- denotes (
T1811 3737-3742 NN denotes group
T1810 3730-3736 JJ denotes normal
T1809 3728-3729 -COLON- denotes :
T1808 3722-3728 NN denotes groups
T1807 3716-3721 CD denotes three
T1806 3713-3715 TO denotes to
T1805 3704-3712 RB denotes randomly
T1804 3695-3703 VB denotes assigned
T1803 3690-3694 VB denotes were
T1802 3685-3689 NN denotes rats
T1801 3681-3684 DT denotes The
T1800 3669-3680 NNP denotes University.
T1799 3661-3668 NNP denotes Medical
T1798 3655-3660 NNP denotes China
T1797 3653-3654 -COMMA- denotes ,
T1796 3647-3653 NNP denotes Center
T1795 3640-3646 NNP denotes Animal
T1283 3524-3527 NN denotes ICH
T1282 3518-3523 IN denotes after
T1281 3511-3517 NN denotes tissue
T1280 3505-3510 NN denotes brain
T1279 3501-3504 NN denotes rat
T1278 3498-3500 IN denotes in
T1277 3488-3497 NN denotes signaling
T1276 3474-3487 JJ denotes TLR4-mediated
T1275 3471-3473 IN denotes of
T1274 3460-3470 NN denotes activation
T1273 3456-3459 DT denotes the
T1272 3453-3455 IN denotes of
T1271 3445-3452 NN denotes profile
T1270 3436-3444 JJ denotes temporal
T1269 3432-3435 DT denotes the
T1268 3428-3431 CC denotes and
T1267 3423-3427 NN denotes TLR4
T1266 3420-3422 IN denotes of
T1265 3407-3419 NN denotes distribution
T1264 3403-3406 DT denotes the
T1263 3397-3402 IN denotes about
T1262 3387-3396 NN denotes knowledge
T1261 3383-3386 DT denotes the
T1260 3374-3382 VB denotes provided
T1259 3366-3373 RB denotes firstly
T1258 3361-3365 NN denotes data
T1257 3357-3360 PRP-DOLLAR- denotes Our
T1256 3352-3355 NN denotes ICH
T1255 3339-3351 JJ denotes experimental
T1254 3336-3338 TO denotes to
T1253 3326-3335 VB denotes subjected
T1252 3319-3325 NN denotes brains
T1251 3315-3318 NN denotes rat
T1250 3311-3314 DT denotes the
T1249 3308-3310 IN denotes in
T1248 3298-3307 NN denotes signaling
T1247 3284-3297 JJ denotes TLR4-mediated
T1246 3281-3283 IN denotes of
T1245 3270-3280 NN denotes activation
T1244 3266-3269 DT denotes the
T1243 3262-3265 CC denotes and
T1242 3257-3261 NN denotes gene
T1241 3252-3256 NN denotes TLR4
T1240 3249-3251 IN denotes of
T1239 3235-3248 NN denotes transcription
T1238 3231-3234 DT denotes the
T1237 3222-3230 VB denotes detected
T1236 3219-3221 PRP denotes we
T1235 3217-3218 -COMMA- denotes ,
T1234 3212-3217 NN denotes study
T1233 3204-3211 JJ denotes present
T1232 3200-3203 DT denotes the
T1231 3197-3199 IN denotes In
T1230 3192-3195 NN denotes ICH
T1229 3186-3191 IN denotes after
T1228 3180-3185 NN denotes brain
T1227 3176-3179 DT denotes the
T1226 3173-3175 IN denotes in
T1225 3168-3172 NN denotes TLR4
T1224 3162-3167 IN denotes about
T1223 3156-3161 VB denotes known
T1222 3153-3155 VB denotes is
T1221 3146-3152 JJ denotes little
T1220 3144-3145 -COMMA- denotes ,
T1219 3137-3144 RB denotes However
T1218 3134-3135 -RRB- denotes ]
T1217 3133-3134 CD denotes 9
T1216 3131-3132 -COMMA- denotes ,
T1215 3130-3131 CD denotes 8
T1214 3129-3130 -LRB- denotes [
T1213 3120-3128 NN denotes ischemia
T1212 3117-3119 IN denotes by
T1211 3109-3116 VB denotes induced
T1210 3102-3108 NN denotes injury
T1209 3096-3101 NN denotes brain
T1208 3092-3095 DT denotes the
T1207 3089-3091 IN denotes in
T1206 3079-3088 NN denotes responses
T1205 3066-3078 JJ denotes inflammatory
T1204 3062-3065 CC denotes and
T1203 3060-3061 -COMMA- denotes ,
T1202 3055-3060 NN denotes edema
T1794 3627-3639 NNP denotes Experimental
T1793 3624-3626 IN denotes by
T1792 3615-3623 VB denotes provided
T1791 3610-3614 VB denotes were
T1790 3608-3609 -RRB- denotes )
T1789 3603-3608 CD denotes 300 g
T1788 3600-3602 TO denotes to
T1787 3594-3599 CD denotes 250 g
T1786 3592-3593 -COLON- denotes :
T1785 3586-3592 NN denotes weight
T1784 3581-3585 NN denotes body
T1783 3579-3580 -COMMA- denotes ,
T1782 3575-3579 NN denotes male
T1781 3574-3575 -LRB- denotes (
T1780 3569-3573 NN denotes rats
T1779 3562-3568 NNP denotes Wister
T1778 3555-3561 NNP denotes Ninety
T1777 3547-3554 NN denotes Animals
T1776 3542-3545 CD denotes 2.1
T1201 3049-3054 NN denotes brain
T1200 3047-3048 -COMMA- denotes ,
T1199 3041-3047 NN denotes damage
T1198 3033-3040 NN denotes barrier
T1197 3027-3032 NN denotes brain
T1196 3021-3026 NN denotes blood
T1195 3019-3020 -COMMA- denotes ,
T1194 3014-3019 NN denotes death
T1193 3005-3013 JJ denotes neuronal
T1192 3001-3004 DT denotes the
T1191 2998-3000 TO denotes to
T1190 2986-2997 VB denotes contributes
T1189 2984-2985 -COMMA- denotes ,
T1188 2974-2984 VB denotes recognized
T1187 2970-2973 NN denotes TLR
T1186 2960-2969 JJ denotes mammalian
T1185 2954-2959 JJ denotes first
T1184 2950-2953 DT denotes the
T1183 2948-2949 -COMMA- denotes ,
T1182 2944-2948 NN denotes TLR4
T1181 2939-2943 IN denotes that
T1180 2927-2938 VB denotes demonstrate
T1179 2917-2926 NN denotes evidences
T1178 2904-2916 VB denotes Accumulating
T1177 2901-2902 -RRB- denotes ]
T1176 2900-2901 CD denotes 8
T1175 2898-2899 -COMMA- denotes ,
T1174 2897-2898 CD denotes 7
T1173 2896-2897 -LRB- denotes [
T1172 2889-2895 NN denotes injury
T1171 2883-2888 NN denotes brain
T1170 2874-2882 JJ denotes ischemic
T1169 2870-2873 CC denotes and
T1168 2868-2869 -COMMA- denotes ,
T1167 2861-2868 NN denotes disease
T1166 2850-2860 JJ denotes autoimmune
T1165 2848-2849 -COMMA- denotes ,
T1164 2841-2848 NN denotes disease
T1163 2830-2840 JJ denotes infectious
T1162 2827-2829 IN denotes as
T1161 2822-2826 JJ denotes such
T1160 2820-2821 -COMMA- denotes ,
T1159 2812-2820 NN denotes diseases
T1158 2808-2811 NN denotes CNS
T1157 2800-2807 JJ denotes several
T1156 2797-2799 IN denotes in
T1155 2786-2796 VB denotes implicated
T1154 2782-2785 VB denotes are
T1153 2778-2781 CC denotes and
T1152 2768-2777 NN denotes responses
T1151 2741-2767 JJ denotes immunological/inflammatory
T1150 2738-2740 IN denotes of
T1146 2716-2720 NN denotes role
T1145 2707-2715 JJ denotes critical
T1144 2705-2706 DT denotes a
T1143 2700-2704 VB denotes play
T1142 2695-2699 NN denotes TLRs
T1141 2692-2693 -RRB- denotes ]
T1140 2691-2692 CD denotes 6
T1139 2689-2690 -COMMA- denotes ,
T1138 2688-2689 CD denotes 5
T1137 2687-2688 -LRB- denotes [
T1136 2677-2686 NN denotes responses
T1135 2664-2676 JJ denotes inflammatory
T1134 2661-2663 TO denotes to
T1133 2653-2660 VB denotes related
T1132 2647-2652 NN denotes genes
T1131 2644-2646 IN denotes of
T1130 2630-2643 NN denotes transcription
T1129 2626-2629 DT denotes the
T1128 2616-2625 VB denotes regulates
T1127 2612-2615 CC denotes and
T1126 2602-2611 VB denotes activates
T1125 2598-2601 CC denotes and
T1124 2590-2597 NN denotes nucleus
T1123 2586-2589 DT denotes the
T1122 2581-2585 IN denotes into
T1121 2567-2580 NN denotes trans-locates
T1120 2562-2566 NN denotes NFκB
T1119 2560-2561 -COMMA- denotes ,
T1118 2556-2560 RB denotes Then
T1117 2553-2554 -RRB- denotes )
T1116 2549-2553 NN denotes NFκB
T1115 2548-2549 -LRB- denotes (
T1114 2537-2547 NN denotes NF-kappa-B
T1113 2532-2536 IN denotes from
T1112 2528-2531 NN denotes IκB
T1111 2516-2527 VB denotes dissociates
T1110 2512-2515 CC denotes and
T1109 2510-2511 -RRB- denotes )
T1108 2507-2510 NN denotes IκB
T1107 2506-2507 -LRB- denotes (
T1106 2498-2505 NN denotes kappa-B
T1105 2495-2497 IN denotes of
T1104 2485-2494 NN denotes inhibitor
T1103 2482-2484 IN denotes of
T1102 2466-2481 NN denotes phosphorylation
T1101 2462-2465 DT denotes the
T1100 2454-2461 VB denotes induces
T1099 2449-2453 NN denotes TLR4
T1098 2446-2448 IN denotes of
T1097 2435-2445 NN denotes activation
T1096 2431-2434 DT denotes the
T1095 2429-2430 -COMMA- denotes ,
T1094 2423-2429 NN denotes ligand
T1093 2414-2422 JJ denotes specific
T1092 2409-2413 IN denotes with
T1091 2400-2408 VB denotes combined
T1090 2398-2399 -COMMA- denotes ,
T1089 2391-2398 NN denotes example
T1088 2387-2390 IN denotes For
T1087 2384-2385 -RRB- denotes ]
T1086 2383-2384 CD denotes 6
T1085 2381-2382 -COMMA- denotes ,
T1084 2380-2381 CD denotes 5
T1083 2379-2380 -LRB- denotes [
T1082 2369-2378 NN denotes cytokines
T1081 2365-2368 CC denotes and
T1080 2355-2364 NN denotes molecules
T1079 2331-2354 JJ denotes inflammation-associated
T1078 2322-2330 VB denotes encoding
T1077 2316-2321 NN denotes genes
T1076 2313-2315 IN denotes of
T1075 2299-2312 NN denotes transcription
T1074 2296-2298 IN denotes in
T1073 2288-2295 VB denotes results
T1072 2284-2287 CC denotes and
T1071 2275-2283 NN denotes proteins
T1070 2265-2274 NN denotes signaling
T1069 2254-2264 JJ denotes downstream
T1068 2245-2253 VB denotes recruits
T1067 2240-2244 NN denotes TLRs
T1066 2237-2239 IN denotes of
T1065 2226-2236 NN denotes Activation
T1064 2223-2224 -RRB- denotes ]
T1063 2222-2223 CD denotes 4
T1062 2221-2222 -LRB- denotes [
T1061 2211-2220 NN denotes molecules
T1060 2198-2210 NN denotes transduction
T1059 2191-2197 NN denotes signal
T1058 2188-2190 IN denotes as
T1057 2184-2187 VB denotes act
T1056 2180-2183 CC denotes and
T1055 2171-2179 NN denotes proteins
T1054 2157-2170 NN denotes transmembrane
T1053 2154-2156 IN denotes of
T1052 2147-2153 NN denotes family
T1051 2145-2146 DT denotes a
T1050 2141-2144 VB denotes are
T1049 2136-2140 NN denotes TLRs
T1048 2124-2134 VB denotes elucidated
T1047 2121-2123 VB denotes be
T1046 2118-2120 TO denotes to
T1045 2110-2117 VB denotes remains
T1044 2100-2109 VB denotes regulated
T1043 2096-2099 CC denotes and
T1042 2086-2095 VB denotes triggered
T1041 2082-2085 VB denotes are
T1040 2078-2081 NN denotes ICH
T1039 2075-2077 IN denotes in
T1038 2065-2074 NN denotes responses
T1037 2052-2064 JJ denotes inflammatory
T1036 2048-2051 DT denotes the
T1035 2044-2047 WRB denotes how
T1034 2042-2043 -COMMA- denotes ,
T1033 2030-2042 RB denotes Nevertheless
T1032 2022-2028 NN denotes stroke
T1031 2013-2021 JJ denotes ischemic
T1030 2007-2012 IN denotes after
T1029 2000-2006 NN denotes injury
T1028 1994-1999 NN denotes brain
T1027 1991-1993 IN denotes of
T1026 1979-1990 NN denotes progression
T1025 1975-1978 DT denotes the
T1024 1972-1974 IN denotes in
T1023 1960-1971 VB denotes participate
T1022 1957-1959 TO denotes to
T1021 1951-1956 VB denotes shown
T1020 1943-1950 RB denotes clearly
T1019 1938-1942 VB denotes been
T1018 1933-1937 VB denotes have
T1017 1922-1932 NN denotes mechanisms
T1016 1895-1921 JJ denotes immunological/inflammatory
T1015 1886-1894 JJ denotes adaptive
T1014 1882-1885 CC denotes and
T1013 1875-1881 JJ denotes innate
T1012 1870-1874 CC denotes Both
T1011 1867-1868 -RRB- denotes ]
T1010 1866-1867 CD denotes 3
T1009 1865-1866 -LRB- denotes [
T1008 1861-1864 NN denotes ICH
T1007 1851-1860 VB denotes following
T1006 1844-1850 NN denotes damage
T1005 1838-1843 NN denotes brain
T1004 1830-1837 JJ denotes further
T1003 1827-1829 IN denotes in
T1002 1820-1826 NN denotes result
T1001 1816-1819 NN denotes ICH
T1000 1813-1815 IN denotes by
T999 1805-1812 VB denotes induced
T998 1798-1804 NN denotes tissue
T997 1792-1797 NN denotes brain
T996 1788-1791 DT denotes the
T995 1785-1787 IN denotes in
T994 1775-1784 NN denotes responses
T993 1762-1774 JJ denotes inflammatory
T992 1758-1761 CC denotes and
T991 1743-1757 NN denotes excitotoxicity
T990 1739-1742 DT denotes the
T989 1737-1738 -COMMA- denotes ,
T988 1726-1737 RB denotes importantly
T987 1721-1725 RB denotes more
T986 1719-1720 -COLON- denotes ;
T985 1716-1719 NN denotes ICH
T984 1710-1715 IN denotes after
T983 1703-1709 NN denotes damage
T982 1697-1702 NN denotes brain
T981 1689-1696 JJ denotes primary
T980 1681-1688 VB denotes induces
T979 1669-1680 NN denotes deformation
T978 1662-1668 NN denotes tissue
T977 1656-1661 NN denotes brain
T976 1650-1655 JJ denotes Local
T975 1647-1648 -RRB- denotes ]
T974 1646-1647 CD denotes 2
T973 1644-1645 -COMMA- denotes ,
T972 1643-1644 CD denotes 1
T971 1642-1643 -LRB- denotes [
T970 1632-1641 NN denotes survivors
T969 1629-1631 IN denotes in
T968 1618-1628 NN denotes disability
T967 1611-1617 JJ denotes severe
T966 1607-1610 CC denotes and
T965 1597-1606 NN denotes mortality
T964 1592-1596 JJ denotes high
T963 1587-1591 IN denotes with
T962 1576-1586 VB denotes associated
T961 1573-1575 VB denotes is
T960 1567-1572 WDT denotes which
T959 1565-1566 -COMMA- denotes ,
T958 1559-1565 NN denotes stroke
T957 1550-1558 JJ denotes ischemic
T956 1547-1549 IN denotes of
T955 1537-1546 NN denotes treatment
T954 1524-1536 JJ denotes thrombolytic
T953 1520-1523 DT denotes the
T952 1517-1519 IN denotes of
T951 1504-1516 NN denotes complication
T950 1502-1503 DT denotes a
T949 1499-1501 IN denotes as
T948 1489-1498 NN denotes frequency
T947 1478-1488 VB denotes increasing
T946 1473-1477 IN denotes with
T945 1466-1472 VB denotes occurs
T944 1462-1465 CC denotes and
T943 1454-1461 NN denotes strokes
T942 1450-1453 DT denotes all
T941 1447-1449 IN denotes of
T940 1445-1446 NN denotes %
T939 1442-1445 CD denotes –15
T938 1441-1442 NN denotes %
T937 1439-1441 CD denotes 10
T936 1428-1438 VB denotes represents
T935 1426-1427 -RRB- denotes )
T934 1423-1426 NN denotes ICH
T933 1422-1423 -LRB- denotes (
T932 1411-1421 NN denotes hemorrhage
T931 1397-1410 JJ denotes Intracerebral
T1149 2728-2737 NN denotes induction
T1148 2724-2727 DT denotes the
T1147 2721-2723 IN denotes in
T383 1372-1378 NN denotes damage
T382 1366-1371 NN denotes brain
T381 1354-1365 JJ denotes ICH-induced
T380 1350-1353 IN denotes for
T379 1343-1349 NN denotes target
T378 1331-1342 JJ denotes therapeutic
T377 1329-1330 DT denotes a
T376 1322-1328 VB denotes become
T375 1318-1321 MD denotes may
T374 1312-1317 WDT denotes which
T373 1310-1311 -COMMA- denotes ,
T372 1307-1310 NN denotes ICH
T371 1304-1306 IN denotes of
T370 1291-1303 NN denotes pathogenesis
T369 1287-1290 DT denotes the
T368 1284-1286 IN denotes in
T367 1271-1283 VB denotes participates
T366 1261-1270 NN denotes signaling
T365 1256-1260 NN denotes NFκB
T364 1242-1255 JJ denotes TLR4-mediated
T363 1237-1241 IN denotes that
T362 1228-1236 VB denotes suggests
T361 1220-1227 RB denotes firstly
T360 1214-1219 NN denotes study
T359 1206-1213 JJ denotes present
T358 1202-1205 DT denotes The
T357 1193-1200 NN denotes control
T356 1186-1192 NN denotes saline
T355 1181-1185 IN denotes with
T335 1081-1082 SYM denotes <
T334 1079-1080 NN denotes P
T333 1078-1079 -LRB- denotes (
T332 1074-1077 NN denotes ICH
T331 1068-1073 IN denotes after
T330 1064-1067 NN denotes day
T329 1060-1063 JJ denotes 7th
T328 1056-1059 DT denotes the
T327 1053-1055 IN denotes on
T326 1047-1052 NN denotes level
T325 1040-1046 JJ denotes higher
T324 1038-1039 DT denotes a
T323 1035-1037 IN denotes at
T322 1024-1034 VB denotes maintained
T321 1018-1023 RB denotes still
T320 1014-1017 CC denotes but
T319 1004-1013 VB denotes decreased
T318 999-1003 RB denotes then
T317 995-998 CC denotes and
T316 993-994 -COMMA- denotes ,
T315 990-993 NN denotes ICH
T314 984-989 IN denotes after
T313 980-983 NN denotes day
T312 976-979 JJ denotes 3rd
T311 972-975 DT denotes the
T310 969-971 IN denotes on
T309 962-968 VB denotes peaked
T308 960-961 -COMMA- denotes ,
T307 957-960 NN denotes ICH
T306 951-956 IN denotes after
T305 943-950 NN denotes 6 hours
T304 940-942 IN denotes at
T303 931-939 VB denotes starting
T302 921-930 VB denotes increased
T301 907-920 RB denotes significantly
T300 899-906 NN denotes protein
T299 895-898 CC denotes and
T298 890-894 NN denotes mRNA
T297 885-889 NN denotes TLR4
T296 881-884 DT denotes the
T295 879-880 -COMMA- denotes ,
T294 872-879 NN denotes control
T293 865-871 NN denotes saline
T292 860-864 IN denotes with
T291 851-859 VB denotes Compared
T290 845-849 NN denotes EMSA
T289 841-844 CC denotes and
T288 839-840 -COMMA- denotes ,
T287 831-839 NN denotes staining
T286 810-830 NN denotes immunohistochemistry
T285 808-809 -COMMA- denotes ,
T284 803-808 NN denotes blots
T283 795-802 JJ denotes Western
T282 793-794 -COMMA- denotes ,
T281 787-793 NN denotes Rt-PCR
T280 784-786 IN denotes by
T279 777-783 NN denotes tissue
T278 768-776 JJ denotes cerebral
T277 756-767 JJ denotes hemorrhagic
T276 753-755 IN denotes in
T275 744-752 VB denotes examined
T274 739-743 VB denotes were
T273 734-738 NN denotes NFκB
T272 731-733 IN denotes of
T271 722-730 NN denotes activity
T270 718-721 DT denotes the
T269 714-717 CC denotes and
T268 712-713 -COMMA- denotes ,
T267 711-712 -RRB- denotes )
T266 705-711 NN denotes p-IκBα
T265 704-705 -LRB- denotes (
T264 702-703 NN denotes B
T263 696-701 NN denotes kappa
T262 693-695 IN denotes of
T261 682-692 NN denotes inhibitors
T260 679-681 IN denotes of
T259 663-678 NN denotes phosphorylation
T258 659-662 DT denotes the
T257 657-658 -COMMA- denotes ,
T256 650-657 NN denotes protein
T255 646-649 CC denotes and
T254 641-645 NN denotes mRNA
T253 636-640 NN denotes TLR4
T252 631-634 NN denotes ICH
T251 625-630 IN denotes after
T250 620-624 NN denotes rats
T249 613-619 NNP denotes Wistar
T248 610-612 IN denotes of
T247 602-609 NN denotes tissues
T246 596-601 NN denotes brain
T245 593-595 IN denotes in
T244 583-592 NN denotes signaling
T243 578-582 NN denotes NFκB
T242 564-577 JJ denotes TLR4-mediated
T241 561-563 IN denotes of
T240 550-560 NN denotes activation
T239 546-549 DT denotes the
T238 542-545 CC denotes and
T237 537-541 NN denotes TLR4
T236 534-536 IN denotes of
T235 523-533 NN denotes expression
T234 519-522 DT denotes the
T233 516-518 IN denotes of
T232 508-515 NN denotes profile
T231 499-507 JJ denotes temporal
T230 495-498 DT denotes the
T229 486-494 VB denotes evaluate
T228 483-485 TO denotes to
T227 479-482 VB denotes was
T226 473-478 NN denotes study
T225 465-472 JJ denotes present
T224 461-464 DT denotes The
T223 452-459 JJ denotes unknown
T222 444-451 VB denotes remains
T221 440-443 NN denotes ICH
T220 437-439 IN denotes of
T219 424-436 NN denotes pathogenesis
T218 420-423 DT denotes the
T217 417-419 IN denotes in
T216 407-416 NN denotes signaling
T215 402-406 NN denotes NFκB
T214 388-401 JJ denotes TLR4-mediated
T213 385-387 IN denotes of
T212 373-384 NN denotes involvement
T211 369-372 DT denotes the
T210 367-368 -COMMA- denotes ,
T209 360-367 RB denotes However
T208 353-358 NN denotes brain
T207 345-352 JJ denotes injured
T206 342-344 IN denotes in
T205 332-341 NN denotes responses
T204 319-331 JJ denotes inflammatory
T203 316-318 IN denotes of
T202 305-315 NN denotes regulation
T201 301-304 CC denotes and
T200 290-300 NN denotes activation
T199 286-289 DT denotes the
T198 283-285 IN denotes in
T197 277-282 NN denotes roles
T196 268-276 JJ denotes critical
T195 262-267 VB denotes plays
T194 252-261 NN denotes signaling
T193 250-251 -RRB- denotes )
T192 246-250 NN denotes NFκB
T191 245-246 -LRB- denotes (
T190 237-244 NN denotes kappa-B
T189 230-236 NN denotes factor
T188 222-229 JJ denotes nuclear
T187 213-221 VB denotes mediated
T186 211-212 -RRB- denotes )
T185 206-211 NN denotes TLR4-
T184 205-206 -LRB- denotes (
T183 202-204 NN denotes 4-
T182 193-201 NN denotes receptor
T181 183-192 JJ denotes Toll-like
T180 180-181 -RRB- denotes )
T179 177-180 NN denotes ICH
T178 176-177 -LRB- denotes (
T177 165-175 NN denotes hemorrhage
T176 151-164 JJ denotes Intracerebral
T175 148-150 IN denotes of
T174 135-147 NN denotes pathogenesis
T173 131-134 DT denotes the
T172 128-130 IN denotes in
T171 123-127 NN denotes role
T170 115-122 JJ denotes crucial
T169 113-114 DT denotes a
T168 108-112 VB denotes play
T167 99-107 NN denotes immunity
T166 95-98 CC denotes and
T165 82-94 NN denotes Inflammation
T354 1172-1180 VB denotes compared
T353 1168-1171 NN denotes ICH
T352 1162-1167 IN denotes after
T351 1156-1161 NN denotes brain
T350 1152-1155 DT denotes the
T349 1149-1151 IN denotes in
T348 1139-1148 VB denotes increased
T347 1134-1138 RB denotes also
T346 1129-1133 NN denotes NFκB
T345 1126-1128 IN denotes of
T344 1117-1125 NN denotes activity
T343 1113-1116 DT denotes the
T342 1109-1112 CC denotes and
T341 1102-1108 NN denotes p-IκBα
T340 1099-1101 IN denotes of
T339 1093-1098 NN denotes level
T338 1089-1092 DT denotes The
T337 1086-1087 -RRB- denotes )
T336 1083-1086 CD denotes .05
R25 T155 T156 arg1Of Activation,of
R26 T155 T160 arg1Of Activation,in
R27 T159 T156 arg2Of Signaling,of
R28 T159 T157 arg1Of Signaling,TLR4-Mediated
R29 T159 T158 arg1Of Signaling,NFκB
R30 T162 T160 arg2Of Brain,in
R31 T162 T161 arg1Of Brain,Hemorrhagic
R32 T162 T163 arg1Of Brain,in
R33 T164 T163 arg2Of Rats,in
R34 T165 T166 arg1Of Inflammation,and
R35 T166 T168 arg1Of and,play
R36 T167 T166 arg2Of immunity,and
R37 T168 T172 arg1Of play,in
R38 T171 T168 arg2Of role,play
R39 T171 T169 arg1Of role,a
R40 T171 T170 arg1Of role,crucial
R41 T174 T172 arg2Of pathogenesis,in
R42 T174 T173 arg1Of pathogenesis,the
R43 T174 T175 arg1Of pathogenesis,of
R44 T177 T175 arg2Of hemorrhage,of
R45 T177 T176 arg1Of hemorrhage,Intracerebral
R46 T177 T178 arg1Of hemorrhage,(
R47 T179 T178 arg2Of ICH,(
R48 T180 T178 arg3Of ),(
R49 T183 T181 arg1Of 4-,Toll-like
R50 T183 T182 arg1Of 4-,receptor
R51 T183 T184 arg1Of 4-,(
R52 T185 T184 arg2Of TLR4-,(
R53 T186 T184 arg3Of ),(
R54 T192 T191 arg2Of NFκB,(
R55 T193 T191 arg3Of ),(
R56 T194 T183 arg1Of signaling,4-
R57 T194 T187 arg2Of signaling,mediated
R58 T194 T188 arg1Of signaling,nuclear
R59 T194 T189 arg1Of signaling,factor
R60 T194 T190 arg1Of signaling,kappa-B
R61 T194 T191 arg1Of signaling,(
R62 T194 T195 arg1Of signaling,plays
R63 T195 T198 arg1Of plays,in
R64 T197 T195 arg2Of roles,plays
R65 T197 T196 arg1Of roles,critical
R66 T200 T201 arg1Of activation,and
R67 T201 T198 arg2Of and,in
R68 T201 T199 arg1Of and,the
R69 T201 T203 arg1Of and,of
R70 T201 T206 arg1Of and,in
R71 T202 T201 arg2Of regulation,and
R72 T205 T203 arg2Of responses,of
R73 T205 T204 arg1Of responses,inflammatory
R74 T208 T206 arg2Of brain,in
R75 T208 T207 arg1Of brain,injured
R76 T212 T211 arg1Of involvement,the
R77 T212 T213 arg1Of involvement,of
R78 T212 T217 arg1Of involvement,in
R79 T212 T222 arg1Of involvement,remains
R80 T212 T223 arg1Of involvement,unknown
R81 T216 T213 arg2Of signaling,of
R82 T216 T214 arg1Of signaling,TLR4-mediated
R83 T216 T215 arg1Of signaling,NFκB
R84 T219 T217 arg2Of pathogenesis,in
R85 T219 T218 arg1Of pathogenesis,the
R86 T219 T220 arg1Of pathogenesis,of
R87 T221 T220 arg2Of ICH,of
R88 T222 T209 arg1Of remains,However
R89 T222 T210 arg1Of remains,","
R90 T223 T222 arg2Of unknown,remains
R91 T226 T224 arg1Of study,The
R92 T226 T225 arg1Of study,present
R93 T226 T227 arg1Of study,was
R94 T229 T227 arg2Of evaluate,was
R95 T229 T228 arg1Of evaluate,to
R96 T232 T230 arg1Of profile,the
R97 T232 T231 arg1Of profile,temporal
R98 T232 T233 arg1Of profile,of
R99 T232 T238 arg1Of profile,and
R100 T235 T233 arg2Of expression,of
R101 T235 T234 arg1Of expression,the
R102 T235 T236 arg1Of expression,of
R103 T237 T236 arg2Of TLR4,of
R104 T238 T229 arg2Of and,evaluate
R105 T240 T238 arg2Of activation,and
R106 T240 T239 arg1Of activation,the
R107 T240 T241 arg1Of activation,of
R108 T240 T245 arg1Of activation,in
R109 T244 T241 arg2Of signaling,of
R110 T244 T242 arg1Of signaling,TLR4-mediated
R111 T244 T243 arg1Of signaling,NFκB
R112 T247 T245 arg2Of tissues,in
R113 T247 T246 arg1Of tissues,brain
R114 T247 T248 arg1Of tissues,of
R115 T250 T248 arg2Of rats,of
R116 T250 T249 arg1Of rats,Wistar
R117 T250 T251 arg1Of rats,after
R118 T252 T251 arg2Of ICH,after
R119 T254 T255 arg1Of mRNA,and
R120 T255 T253 arg1Of and,TLR4
R121 T255 T257 arg1Of and,","
R122 T255 T269 arg1Of and,and
R123 T256 T255 arg2Of protein,and
R124 T259 T257 arg2Of phosphorylation,","
R125 T259 T258 arg1Of phosphorylation,the
R126 T259 T260 arg1Of phosphorylation,of
R127 T261 T260 arg2Of inhibitors,of
R128 T261 T262 arg1Of inhibitors,of
R129 T264 T262 arg2Of B,of
R130 T264 T263 arg1Of B,kappa
R131 T264 T265 arg1Of B,(
R132 T266 T265 arg2Of p-IκBα,(
R133 T267 T265 arg3Of ),(
R134 T269 T268 arg1Of and,","
R135 T269 T274 arg1Of and,were
R136 T269 T275 arg2Of and,examined
R137 T271 T269 arg2Of activity,and
R138 T271 T270 arg1Of activity,the
R139 T271 T272 arg1Of activity,of
R140 T273 T272 arg2Of NFκB,of
R141 T275 T274 arg2Of examined,were
R142 T275 T276 arg1Of examined,in
R143 T279 T276 arg2Of tissue,in
R144 T279 T277 arg1Of tissue,hemorrhagic
R145 T279 T278 arg1Of tissue,cerebral
R146 T281 T282 arg1Of Rt-PCR,","
R147 T282 T285 arg1Of ",",","
R148 T284 T282 arg2Of blots,","
R149 T284 T283 arg1Of blots,Western
R150 T285 T289 arg1Of ",",and
R151 T287 T285 arg2Of staining,","
R152 T287 T286 arg1Of staining,immunohistochemistry
R153 T289 T275 arg1Of and,examined
R154 T289 T280 arg2Of and,by
R155 T289 T288 arg1Of and,","
R156 T290 T289 arg2Of EMSA,and
R157 T292 T291 arg2Of with,Compared
R158 T294 T292 arg2Of control,with
R159 T294 T293 arg1Of control,saline
R160 T298 T297 arg1Of mRNA,TLR4
R161 T298 T299 arg1Of mRNA,and
R162 T299 T296 arg1Of and,the
R163 T299 T302 arg1Of and,increased
R164 T299 T309 arg1Of and,peaked
R165 T299 T319 arg1Of and,decreased
R166 T299 T322 arg2Of and,maintained
R167 T300 T299 arg2Of protein,and
R168 T302 T308 arg1Of increased,","
R169 T303 T302 arg2Of starting,increased
R170 T303 T304 arg1Of starting,at
R171 T303 T306 arg1Of starting,after
R172 T305 T304 arg2Of 6 hours,at
R173 T307 T306 arg2Of ICH,after
R174 T308 T317 arg1Of ",",and
R175 T309 T308 arg2Of peaked,","
R176 T309 T310 arg1Of peaked,on
R177 T313 T310 arg2Of day,on
R178 T313 T311 arg1Of day,the
R179 T313 T312 arg1Of day,3rd
R180 T313 T314 arg1Of day,after
R181 T315 T314 arg2Of ICH,after
R182 T317 T291 arg1Of and,Compared
R183 T317 T295 arg1Of and,","
R184 T317 T301 arg1Of and,significantly
R185 T317 T316 arg1Of and,","
R186 T319 T320 arg1Of decreased,but
R187 T320 T317 arg2Of but,and
R188 T320 T318 arg1Of but,then
R189 T322 T320 arg2Of maintained,but
R190 T322 T321 arg1Of maintained,still
R191 T322 T323 arg1Of maintained,at
R192 T322 T327 arg1Of maintained,on
R193 T322 T331 arg1Of maintained,after
R194 T326 T323 arg2Of level,at
R195 T326 T324 arg1Of level,a
R196 T326 T325 arg1Of level,higher
R197 T330 T327 arg2Of day,on
R198 T330 T328 arg1Of day,the
R199 T330 T329 arg1Of day,7th
R200 T332 T331 arg2Of ICH,after
R201 T332 T333 arg1Of ICH,(
R202 T334 T333 arg2Of P,(
R203 T334 T335 arg1Of P,<
R204 T335 T336 arg1Of <,.05
R205 T337 T333 arg3Of ),(
R206 T339 T338 arg1Of level,The
R207 T339 T340 arg1Of level,of
R208 T339 T342 arg1Of level,and
R209 T341 T340 arg2Of p-IκBα,of
R210 T342 T348 arg1Of and,increased
R211 T344 T342 arg2Of activity,and
R212 T344 T343 arg1Of activity,the
R213 T344 T345 arg1Of activity,of
R214 T346 T345 arg2Of NFκB,of
R215 T348 T347 arg1Of increased,also
R216 T348 T349 arg1Of increased,in
R217 T348 T352 arg1Of increased,after
R218 T351 T349 arg2Of brain,in
R219 T351 T350 arg1Of brain,the
R220 T353 T352 arg2Of ICH,after
R221 T353 T354 arg1Of ICH,compared
R222 T355 T354 arg2Of with,compared
R223 T357 T355 arg2Of control,with
R224 T357 T356 arg1Of control,saline
R225 T360 T358 arg1Of study,The
R226 T360 T359 arg1Of study,present
R227 T360 T362 arg1Of study,suggests
R228 T362 T361 arg1Of suggests,firstly
R229 T366 T364 arg1Of signaling,TLR4-mediated
R230 T366 T365 arg1Of signaling,NFκB
R231 T366 T367 arg1Of signaling,participates
R232 T367 T362 arg2Of participates,suggests
R233 T367 T363 arg1Of participates,that
R234 T367 T368 arg1Of participates,in
R235 T370 T368 arg2Of pathogenesis,in
R236 T370 T369 arg1Of pathogenesis,the
R237 T370 T371 arg1Of pathogenesis,of
R238 T370 T373 arg1Of pathogenesis,","
R239 T370 T374 arg1Of pathogenesis,which
R240 T370 T375 arg1Of pathogenesis,may
R241 T370 T376 arg1Of pathogenesis,become
R242 T372 T371 arg2Of ICH,of
R243 T376 T375 arg2Of become,may
R244 T379 T376 arg2Of target,become
R245 T379 T377 arg1Of target,a
R246 T379 T378 arg1Of target,therapeutic
R247 T379 T380 arg1Of target,for
R248 T383 T380 arg2Of damage,for
R249 T383 T381 arg1Of damage,ICH-induced
R250 T383 T382 arg1Of damage,brain
R562 T932 T931 arg1Of hemorrhage,Intracerebral
R563 T932 T933 arg1Of hemorrhage,(
R564 T932 T936 arg1Of hemorrhage,represents
R565 T932 T945 arg1Of hemorrhage,occurs
R566 T934 T933 arg2Of ICH,(
R567 T935 T933 arg3Of ),(
R568 T936 T944 arg1Of represents,and
R569 T940 T936 arg2Of %,represents
R570 T940 T937 arg1Of %,10
R571 T940 T938 arg1Of %,%
R572 T940 T939 arg1Of %,–15
R573 T940 T941 arg1Of %,of
R574 T943 T941 arg2Of strokes,of
R575 T943 T942 arg1Of strokes,all
R576 T945 T944 arg2Of occurs,and
R577 T945 T946 arg1Of occurs,with
R578 T945 T949 arg1Of occurs,as
R579 T948 T946 arg2Of frequency,with
R580 T948 T947 arg1Of frequency,increasing
R581 T951 T949 arg2Of complication,as
R582 T951 T950 arg1Of complication,a
R583 T951 T952 arg1Of complication,of
R584 T955 T952 arg2Of treatment,of
R585 T955 T953 arg1Of treatment,the
R586 T955 T954 arg1Of treatment,thrombolytic
R587 T955 T956 arg1Of treatment,of
R588 T955 T959 arg1Of treatment,","
R589 T955 T960 arg1Of treatment,which
R590 T955 T961 arg1Of treatment,is
R591 T955 T962 arg2Of treatment,associated
R592 T958 T956 arg2Of stroke,of
R593 T958 T957 arg1Of stroke,ischemic
R594 T962 T961 arg2Of associated,is
R595 T962 T963 arg1Of associated,with
R596 T965 T964 arg1Of mortality,high
R597 T965 T966 arg1Of mortality,and
R598 T966 T963 arg2Of and,with
R599 T966 T969 arg1Of and,in
R600 T968 T966 arg2Of disability,and
R601 T968 T967 arg1Of disability,severe
R602 T970 T969 arg2Of survivors,in
R603 T970 T971 arg1Of survivors,[
R604 T972 T971 arg2Of 1,[
R605 T972 T973 arg1Of 1,","
R606 T974 T973 arg2Of 2,","
R607 T975 T971 arg3Of ],[
R608 T979 T976 arg1Of deformation,Local
R609 T979 T977 arg1Of deformation,brain
R610 T979 T978 arg1Of deformation,tissue
R611 T979 T980 arg1Of deformation,induces
R612 T980 T986 arg1Of induces,;
R613 T980 T988 arg1Of induces,importantly
R614 T980 T989 arg1Of induces,","
R615 T983 T980 arg2Of damage,induces
R616 T983 T981 arg1Of damage,primary
R617 T983 T982 arg1Of damage,brain
R618 T983 T984 arg1Of damage,after
R619 T985 T984 arg2Of ICH,after
R620 T988 T987 arg1Of importantly,more
R621 T991 T992 arg1Of excitotoxicity,and
R622 T993 T992 arg2Of inflammatory,and
R623 T994 T989 arg2Of responses,","
R624 T994 T990 arg1Of responses,the
R625 T994 T991 arg1Of responses,excitotoxicity
R626 T994 T993 arg1Of responses,inflammatory
R627 T994 T995 arg1Of responses,in
R628 T998 T995 arg2Of tissue,in
R629 T998 T996 arg1Of tissue,the
R630 T998 T997 arg1Of tissue,brain
R631 T998 T999 arg2Of tissue,induced
R632 T1002 T999 arg1Of result,induced
R633 T1002 T1000 arg2Of result,by
R634 T1002 T1001 arg1Of result,ICH
R635 T1002 T1003 arg1Of result,in
R636 T1002 T1007 arg1Of result,following
R637 T1006 T1003 arg2Of damage,in
R638 T1006 T1004 arg1Of damage,further
R639 T1006 T1005 arg1Of damage,brain
R640 T1008 T1007 arg2Of ICH,following
R641 T1008 T1009 arg1Of ICH,[
R642 T1010 T1009 arg2Of 3,[
R643 T1011 T1009 arg3Of ],[
R644 T1013 T1014 arg1Of innate,and
R645 T1015 T1014 arg2Of adaptive,and
R646 T1017 T1012 arg1Of mechanisms,Both
R647 T1017 T1013 arg1Of mechanisms,innate
R648 T1017 T1015 arg1Of mechanisms,adaptive
R649 T1017 T1016 arg1Of mechanisms,immunological/inflammatory
R650 T1017 T1018 arg1Of mechanisms,have
R651 T1017 T1019 arg1Of mechanisms,been
R652 T1017 T1021 arg2Of mechanisms,shown
R653 T1017 T1023 arg1Of mechanisms,participate
R654 T1021 T1018 arg2Of shown,have
R655 T1021 T1019 arg2Of shown,been
R656 T1021 T1020 arg1Of shown,clearly
R657 T1023 T1021 arg3Of participate,shown
R658 T1023 T1022 arg1Of participate,to
R659 T1023 T1024 arg1Of participate,in
R660 T1026 T1024 arg2Of progression,in
R661 T1026 T1025 arg1Of progression,the
R662 T1026 T1027 arg1Of progression,of
R663 T1026 T1030 arg1Of progression,after
R664 T1029 T1027 arg2Of injury,of
R665 T1029 T1028 arg1Of injury,brain
R666 T1032 T1030 arg2Of stroke,after
R667 T1032 T1031 arg1Of stroke,ischemic
R668 T1035 T1045 arg1Of how,remains
R669 T1035 T1047 arg1Of how,be
R670 T1035 T1048 arg2Of how,elucidated
R671 T1038 T1036 arg1Of responses,the
R672 T1038 T1037 arg1Of responses,inflammatory
R673 T1038 T1039 arg1Of responses,in
R674 T1038 T1041 arg1Of responses,are
R675 T1038 T1042 arg2Of responses,triggered
R676 T1038 T1044 arg2Of responses,regulated
R677 T1040 T1039 arg2Of ICH,in
R678 T1042 T1043 arg1Of triggered,and
R679 T1043 T1035 arg1Of and,how
R680 T1043 T1041 arg2Of and,are
R681 T1044 T1043 arg2Of regulated,and
R682 T1045 T1033 arg1Of remains,Nevertheless
R683 T1045 T1034 arg1Of remains,","
R684 T1048 T1045 arg2Of elucidated,remains
R685 T1048 T1046 arg1Of elucidated,to
R686 T1048 T1047 arg2Of elucidated,be
R687 T1049 T1050 arg1Of TLRs,are
R688 T1049 T1057 arg1Of TLRs,act
R689 T1050 T1056 arg1Of are,and
R690 T1052 T1050 arg2Of family,are
R691 T1052 T1051 arg1Of family,a
R692 T1052 T1053 arg1Of family,of
R693 T1055 T1053 arg2Of proteins,of
R694 T1055 T1054 arg1Of proteins,transmembrane
R695 T1057 T1056 arg2Of act,and
R696 T1057 T1058 arg1Of act,as
R697 T1057 T1062 arg1Of act,[
R698 T1061 T1058 arg2Of molecules,as
R699 T1061 T1059 arg1Of molecules,signal
R700 T1061 T1060 arg1Of molecules,transduction
R701 T1063 T1062 arg2Of 4,[
R702 T1064 T1062 arg3Of ],[
R703 T1065 T1066 arg1Of Activation,of
R704 T1065 T1068 arg1Of Activation,recruits
R705 T1065 T1073 arg1Of Activation,results
R706 T1067 T1066 arg2Of TLRs,of
R707 T1068 T1072 arg1Of recruits,and
R708 T1071 T1068 arg2Of proteins,recruits
R709 T1071 T1069 arg1Of proteins,downstream
R710 T1071 T1070 arg1Of proteins,signaling
R711 T1073 T1072 arg2Of results,and
R712 T1073 T1074 arg1Of results,in
R713 T1075 T1074 arg2Of transcription,in
R714 T1075 T1076 arg1Of transcription,of
R715 T1077 T1076 arg2Of genes,of
R716 T1077 T1078 arg1Of genes,encoding
R717 T1080 T1081 arg1Of molecules,and
R718 T1081 T1078 arg2Of and,encoding
R719 T1081 T1079 arg1Of and,inflammation-associated
R720 T1081 T1083 arg1Of and,[
R721 T1082 T1081 arg2Of cytokines,and
R722 T1084 T1083 arg2Of 5,[
R723 T1084 T1085 arg1Of 5,","
R724 T1086 T1085 arg2Of 6,","
R725 T1087 T1083 arg3Of ],[
R726 T1089 T1088 arg2Of example,For
R727 T1091 T1092 arg1Of combined,with
R728 T1094 T1092 arg2Of ligand,with
R729 T1094 T1093 arg1Of ligand,specific
R730 T1097 T1091 arg2Of activation,combined
R731 T1097 T1096 arg1Of activation,the
R732 T1097 T1098 arg1Of activation,of
R733 T1097 T1100 arg1Of activation,induces
R734 T1097 T1111 arg1Of activation,dissociates
R735 T1099 T1098 arg2Of TLR4,of
R736 T1100 T1110 arg1Of induces,and
R737 T1102 T1100 arg2Of phosphorylation,induces
R738 T1102 T1101 arg1Of phosphorylation,the
R739 T1102 T1103 arg1Of phosphorylation,of
R740 T1104 T1103 arg2Of inhibitor,of
R741 T1104 T1105 arg1Of inhibitor,of
R742 T1106 T1105 arg2Of kappa-B,of
R743 T1106 T1107 arg1Of kappa-B,(
R744 T1108 T1107 arg2Of IκB,(
R745 T1109 T1107 arg3Of ),(
R746 T1110 T1088 arg1Of and,For
R747 T1110 T1090 arg1Of and,","
R748 T1110 T1091 modOf and,combined
R749 T1110 T1095 arg1Of and,","
R750 T1111 T1110 arg2Of dissociates,and
R751 T1112 T1111 arg2Of IκB,dissociates
R752 T1112 T1113 arg1Of IκB,from
R753 T1114 T1113 arg2Of NF-kappa-B,from
R754 T1114 T1115 arg1Of NF-kappa-B,(
R755 T1116 T1115 arg2Of NFκB,(
R756 T1117 T1115 arg3Of ),(
R757 T1120 T1121 arg1Of NFκB,trans-locates
R758 T1120 T1126 arg1Of NFκB,activates
R759 T1120 T1128 arg1Of NFκB,regulates
R760 T1121 T1122 arg1Of trans-locates,into
R761 T1121 T1125 arg1Of trans-locates,and
R762 T1124 T1122 arg2Of nucleus,into
R763 T1124 T1123 arg1Of nucleus,the
R764 T1125 T1118 arg1Of and,Then
R765 T1125 T1119 arg1Of and,","
R766 T1126 T1127 arg1Of activates,and
R767 T1127 T1125 arg2Of and,and
R768 T1128 T1127 arg2Of regulates,and
R769 T1130 T1126 arg2Of transcription,activates
R770 T1130 T1128 arg2Of transcription,regulates
R771 T1130 T1129 arg1Of transcription,the
R772 T1130 T1131 arg1Of transcription,of
R773 T1132 T1131 arg2Of genes,of
R774 T1132 T1133 arg2Of genes,related
R775 T1133 T1134 arg1Of related,to
R776 T1133 T1137 arg1Of related,[
R777 T1136 T1134 arg2Of responses,to
R778 T1136 T1135 arg1Of responses,inflammatory
R779 T1138 T1137 arg2Of 5,[
R780 T1138 T1139 arg1Of 5,","
R781 T1140 T1139 arg2Of 6,","
R782 T1141 T1137 arg3Of ],[
R783 T1142 T1143 arg1Of TLRs,play
R784 T1142 T1154 arg1Of TLRs,are
R785 T1142 T1155 arg2Of TLRs,implicated
R786 T1143 T1147 arg1Of play,in
R787 T1143 T1153 arg1Of play,and
R788 T1146 T1143 arg2Of role,play
R789 T1146 T1144 arg1Of role,a
R790 T1146 T1145 arg1Of role,critical
R791 T1149 T1147 arg2Of induction,in
R792 T1149 T1148 arg1Of induction,the
R793 T1149 T1150 arg1Of induction,of
R794 T1152 T1150 arg2Of responses,of
R795 T1152 T1151 arg1Of responses,immunological/inflammatory
R796 T1155 T1153 arg2Of implicated,and
R797 T1155 T1154 arg2Of implicated,are
R798 T1155 T1156 arg1Of implicated,in
R799 T1159 T1156 arg2Of diseases,in
R800 T1159 T1157 arg1Of diseases,several
R801 T1159 T1158 arg1Of diseases,CNS
R802 T1159 T1160 arg1Of diseases,","
R803 T1159 T1162 arg1Of diseases,as
R804 T1162 T1161 arg1Of as,such
R805 T1164 T1163 arg1Of disease,infectious
R806 T1164 T1165 arg1Of disease,","
R807 T1165 T1169 arg1Of ",",and
R808 T1167 T1165 arg2Of disease,","
R809 T1167 T1166 arg1Of disease,autoimmune
R810 T1169 T1162 arg2Of and,as
R811 T1169 T1168 arg1Of and,","
R812 T1172 T1169 arg2Of injury,and
R813 T1172 T1170 arg1Of injury,ischemic
R814 T1172 T1171 arg1Of injury,brain
R815 T1172 T1173 arg1Of injury,[
R816 T1174 T1173 arg2Of 7,[
R817 T1174 T1175 arg1Of 7,","
R818 T1176 T1175 arg2Of 8,","
R819 T1177 T1173 arg3Of ],[
R820 T1179 T1178 arg1Of evidences,Accumulating
R821 T1179 T1180 arg1Of evidences,demonstrate
R822 T1182 T1183 arg1Of TLR4,","
R823 T1182 T1190 arg1Of TLR4,contributes
R824 T1187 T1183 arg2Of TLR,","
R825 T1187 T1184 arg1Of TLR,the
R826 T1187 T1185 arg1Of TLR,first
R827 T1187 T1186 arg1Of TLR,mammalian
R828 T1187 T1188 arg2Of TLR,recognized
R829 T1190 T1180 arg2Of contributes,demonstrate
R830 T1190 T1181 arg1Of contributes,that
R831 T1190 T1189 arg1Of contributes,","
R832 T1190 T1191 arg1Of contributes,to
R833 T1194 T1192 arg1Of death,the
R834 T1194 T1193 arg1Of death,neuronal
R835 T1194 T1195 arg1Of death,","
R836 T1194 T1200 arg1Of death,","
R837 T1194 T1204 arg1Of death,and
R838 T1199 T1195 arg2Of damage,","
R839 T1199 T1196 arg1Of damage,blood
R840 T1199 T1197 arg1Of damage,brain
R841 T1199 T1198 arg1Of damage,barrier
R842 T1202 T1200 arg2Of edema,","
R843 T1202 T1201 arg1Of edema,brain
R844 T1204 T1191 arg2Of and,to
R845 T1204 T1203 arg1Of and,","
R846 T1206 T1204 arg2Of responses,and
R847 T1206 T1205 arg1Of responses,inflammatory
R848 T1206 T1207 arg1Of responses,in
R849 T1210 T1207 arg2Of injury,in
R850 T1210 T1208 arg1Of injury,the
R851 T1210 T1209 arg1Of injury,brain
R852 T1210 T1211 arg2Of injury,induced
R853 T1211 T1214 arg1Of induced,[
R854 T1213 T1211 arg1Of ischemia,induced
R855 T1213 T1212 arg2Of ischemia,by
R856 T1215 T1214 arg2Of 8,[
R857 T1215 T1216 arg1Of 8,","
R858 T1217 T1216 arg2Of 9,","
R859 T1218 T1214 arg3Of ],[
R860 T1221 T1222 arg1Of little,is
R861 T1221 T1223 arg2Of little,known
R862 T1223 T1219 arg1Of known,However
R863 T1223 T1220 arg1Of known,","
R864 T1223 T1222 arg2Of known,is
R865 T1223 T1224 arg1Of known,about
R866 T1225 T1224 arg2Of TLR4,about
R867 T1225 T1226 arg1Of TLR4,in
R868 T1228 T1226 arg2Of brain,in
R869 T1228 T1227 arg1Of brain,the
R870 T1228 T1229 arg1Of brain,after
R871 T1230 T1229 arg2Of ICH,after
R872 T1234 T1231 arg2Of study,In
R873 T1234 T1232 arg1Of study,the
R874 T1234 T1233 arg1Of study,present
R875 T1236 T1237 arg1Of we,detected
R876 T1237 T1231 arg1Of detected,In
R877 T1237 T1235 arg1Of detected,","
R878 T1239 T1238 arg1Of transcription,the
R879 T1239 T1240 arg1Of transcription,of
R880 T1239 T1243 arg1Of transcription,and
R881 T1242 T1240 arg2Of gene,of
R882 T1242 T1241 arg1Of gene,TLR4
R883 T1243 T1237 arg2Of and,detected
R884 T1245 T1243 arg2Of activation,and
R885 T1245 T1244 arg1Of activation,the
R886 T1245 T1246 arg1Of activation,of
R887 T1245 T1249 arg1Of activation,in
R888 T1248 T1246 arg2Of signaling,of
R889 T1248 T1247 arg1Of signaling,TLR4-mediated
R890 T1252 T1249 arg2Of brains,in
R891 T1252 T1250 arg1Of brains,the
R892 T1252 T1251 arg1Of brains,rat
R893 T1252 T1253 arg2Of brains,subjected
R894 T1253 T1254 arg1Of subjected,to
R895 T1256 T1254 arg2Of ICH,to
R896 T1256 T1255 arg1Of ICH,experimental
R897 T1258 T1257 arg1Of data,Our
R898 T1258 T1260 arg1Of data,provided
R899 T1260 T1259 arg1Of provided,firstly
R900 T1262 T1261 arg1Of knowledge,the
R901 T1262 T1263 arg1Of knowledge,about
R902 T1262 T1268 arg1Of knowledge,and
R903 T1265 T1263 arg2Of distribution,about
R904 T1265 T1264 arg1Of distribution,the
R905 T1265 T1266 arg1Of distribution,of
R906 T1267 T1266 arg2Of TLR4,of
R907 T1268 T1260 arg2Of and,provided
R908 T1271 T1268 arg2Of profile,and
R909 T1271 T1269 arg1Of profile,the
R910 T1271 T1270 arg1Of profile,temporal
R911 T1271 T1272 arg1Of profile,of
R912 T1274 T1272 arg2Of activation,of
R913 T1274 T1273 arg1Of activation,the
R914 T1274 T1275 arg1Of activation,of
R915 T1274 T1278 arg1Of activation,in
R916 T1277 T1275 arg2Of signaling,of
R917 T1277 T1276 arg1Of signaling,TLR4-mediated
R918 T1281 T1278 arg2Of tissue,in
R919 T1281 T1279 arg1Of tissue,rat
R920 T1281 T1280 arg1Of tissue,brain
R921 T1281 T1282 arg1Of tissue,after
R922 T1283 T1282 arg2Of ICH,after
R1324 T1779 T1778 arg1Of Wister,Ninety
R1325 T1780 T1779 arg1Of rats,Wister
R1326 T1780 T1781 arg1Of rats,(
R1327 T1782 T1781 arg2Of male,(
R1328 T1782 T1783 arg1Of male,","
R1329 T1785 T1783 arg2Of weight,","
R1330 T1785 T1784 arg1Of weight,body
R1331 T1786 T1781 arg3Of :,(
R1332 T1787 T1788 arg1Of 250 g,to
R1333 T1789 T1788 arg2Of 300 g,to
R1334 T1792 T1791 arg2Of provided,were
R1335 T1796 T1794 arg1Of Center,Experimental
R1336 T1796 T1795 arg1Of Center,Animal
R1337 T1796 T1797 arg1Of Center,","
R1338 T1799 T1797 arg2Of Medical,","
R1339 T1799 T1798 arg1Of Medical,China
R1340 T1800 T1792 arg1Of University.,provided
R1341 T1800 T1793 arg2Of University.,by
R1342 T1800 T1796 arg1Of University.,Center
R1343 T1800 T1799 arg1Of University.,Medical
R1344 T1802 T1801 arg1Of rats,The
R1345 T1802 T1803 arg1Of rats,were
R1346 T1802 T1804 arg2Of rats,assigned
R1347 T1804 T1803 arg2Of assigned,were
R1348 T1804 T1805 arg1Of assigned,randomly
R1349 T1804 T1806 arg1Of assigned,to
R1350 T1808 T1806 arg2Of groups,to
R1351 T1808 T1807 arg1Of groups,three
R1352 T1811 T1810 arg1Of group,normal
R1353 T1811 T1812 arg1Of group,(
R1354 T1811 T1823 arg1Of group,","
R1355 T1813 T1812 arg2Of N,(
R1356 T1813 T1814 arg1Of N,","
R1357 T1813 T1816 arg1Of N,=
R1358 T1813 T1819 arg1Of N,without
R1359 T1815 T1814 arg2Of n,","
R1360 T1816 T1817 arg1Of =,10
R1361 T1816 T1818 arg1Of =,","
R1362 T1821 T1819 arg2Of treatment,without
R1363 T1821 T1820 arg1Of treatment,any
R1364 T1822 T1812 arg3Of ),(
R1365 T1823 T1809 arg2Of ",",:
R1366 T1826 T1823 arg2Of control,","
R1367 T1826 T1824 arg1Of control,normal
R1368 T1826 T1825 arg1Of control,saline
R1369 T1828 T1829 arg1Of S,","
R1370 T1830 T1829 arg2Of n,","
R1371 T1832 T1831 arg1Of 40,=
R1372 T1832 T1833 arg1Of 40,","
R1373 T1834 T1833 arg2Of intra-cerebral,","
R1374 T1835 T1832 arg1Of injection,40
R1375 T1835 T1834 arg1Of injection,intra-cerebral
R1376 T1835 T1836 arg1Of injection,of
R1377 T1838 T1836 arg2Of saline,of
R1378 T1838 T1837 arg1Of saline,normal
R1379 T1840 T1839 arg2Of control,as
R1380 T1845 T1842 arg2Of group,and
R1381 T1845 T1843 arg1Of group,intra-cerebral
R1382 T1845 T1844 arg1Of group,hemorrhage
R1383 T1845 T1846 arg1Of group,(
R1384 T1847 T1846 arg2Of ICH,(
R1385 T1847 T1848 arg1Of ICH,","
R1386 T1849 T1848 arg2Of n,","
R1387 T1849 T1850 arg1Of n,=
R1388 T1849 T1851 arg1Of n,40
R1389 T1852 T1846 arg3Of ),(
R1390 T1855 T1853 arg1Of protocol,The
R1391 T1855 T1854 arg1Of protocol,experimental
R1392 T1855 T1856 arg2Of protocol,used
R1393 T1855 T1859 arg1Of protocol,was
R1394 T1855 T1860 arg2Of protocol,approved
R1395 T1856 T1857 arg1Of used,for
R1396 T1858 T1857 arg2Of animals,for
R1397 T1860 T1859 arg2Of approved,was
R1398 T1864 T1863 arg1Of Care,Animal
R1399 T1864 T1865 arg1Of Care,and
R1400 T1865 T1860 arg1Of and,approved
R1401 T1865 T1861 arg2Of and,by
R1402 T1865 T1862 arg1Of and,the
R1403 T1867 T1865 arg2Of Committee,and
R1404 T1867 T1866 arg1Of Committee,Use
R1405 T1871 T1869 arg1Of University.,China
R1406 T1871 T1870 arg1Of University.,Medical
R1407 T1873 T1871 arg1Of rats,University.
R1408 T1873 T1872 arg1Of rats,The
R1409 T1873 T1874 arg1Of rats,were
R1410 T1873 T1875 arg2Of rats,subjected
R1411 T1873 T1887 arg1Of rats,were
R1412 T1873 T1888 arg2Of rats,sacrificed
R1413 T1875 T1874 arg2Of subjected,were
R1414 T1875 T1876 arg1Of subjected,to
R1415 T1875 T1886 arg1Of subjected,and
R1416 T1878 T1876 arg2Of injection,to
R1417 T1878 T1877 arg1Of injection,intra-cerebral
R1418 T1878 T1879 arg1Of injection,of
R1419 T1881 T1880 arg1Of saline,normal
R1420 T1881 T1882 arg1Of saline,or
R1421 T1882 T1879 arg2Of or,of
R1422 T1885 T1882 arg2Of blood,or
R1423 T1885 T1883 arg1Of blood,autologous
R1424 T1885 T1884 arg1Of blood,whole
R1425 T1886 T1859 modOf and,was
R1426 T1886 T1868 arg1Of and,","
R1427 T1888 T1886 arg2Of sacrificed,and
R1428 T1888 T1887 arg2Of sacrificed,were
R1429 T1888 T1889 arg1Of sacrificed,on
R1430 T1888 T1900 arg1Of sacrificed,after
R1431 T1888 T1903 arg1Of sacrificed,","
R1432 T1888 T1904 arg1Of sacrificed,respectively
R1433 T1890 T1891 arg1Of 6 hours,","
R1434 T1891 T1894 arg1Of ",",","
R1435 T1893 T1891 arg2Of day,","
R1436 T1893 T1892 arg1Of day,1
R1437 T1894 T1897 arg1Of ",",and
R1438 T1896 T1894 arg2Of days,","
R1439 T1896 T1895 arg1Of days,3
R1440 T1897 T1889 arg2Of and,on
R1441 T1899 T1897 arg2Of days,and
R1442 T1899 T1898 arg1Of days,7
R1443 T1902 T1900 arg2Of injection,after
R1444 T1902 T1901 arg1Of injection,the
R1445 T1906 T1905 arg1Of rats,Five
R1446 T1906 T1907 arg1Of rats,in
R1447 T1906 T1926 arg1Of rats,buffered
R1448 T1909 T1907 arg2Of group,in
R1449 T1909 T1908 arg1Of group,each
R1450 T1909 T1910 arg1Of group,at
R1451 T1912 T1910 arg2Of time,at
R1452 T1912 T1911 arg1Of time,each
R1453 T1913 T1914 arg1Of point,were
R1454 T1913 T1915 arg2Of point,sacrificed
R1455 T1915 T1912 arg2Of sacrificed,time
R1456 T1915 T1914 arg2Of sacrificed,were
R1457 T1918 T1915 arg1Of perfusion,sacrificed
R1458 T1918 T1916 arg2Of perfusion,by
R1459 T1918 T1917 arg1Of perfusion,transcardially
R1460 T1918 T1919 arg1Of perfusion,of
R1461 T1921 T1919 arg2Of saline,of
R1462 T1921 T1920 arg1Of saline,normal
R1463 T1921 T1922 arg2Of saline,followed
R1464 T1922 T1923 arg1Of followed,by
R1465 T1925 T1923 arg2Of %,by
R1466 T1925 T1924 arg1Of %,4
R1467 T1928 T1926 arg2Of formaldehyde,buffered
R1468 T1928 T1927 arg1Of formaldehyde,Para
R1469 T1928 T1929 arg1Of formaldehyde,(
R1470 T1930 T1929 arg2Of pH,(
R1471 T1930 T1931 arg1Of pH,=
R1472 T1930 T1932 arg1Of pH,7.4
R1473 T1933 T1929 arg3Of ),(
R1474 T1935 T1934 arg1Of brains,The
R1475 T1935 T1936 arg1Of brains,were
R1476 T1935 T1937 arg2Of brains,removed
R1477 T1935 T1939 arg2Of brains,postfixed
R1478 T1935 T1941 arg2Of brains,embedded
R1479 T1935 T1946 arg1Of brains,cut
R1480 T1937 T1938 arg1Of removed,","
R1481 T1938 T1940 arg1Of ",",","
R1482 T1939 T1938 arg2Of postfixed,","
R1483 T1940 T1936 arg2Of ",",were
R1484 T1940 T1945 arg1Of ",",and
R1485 T1941 T1940 arg2Of embedded,","
R1486 T1941 T1942 arg1Of embedded,in
R1487 T1943 T1942 arg2Of paraffin,in
R1488 T1945 T1944 arg1Of and,","
R1489 T1946 T1945 arg2Of cut,and
R1490 T1946 T1947 arg1Of cut,into
R1491 T1948 T1947 arg2Of sections,into
R1492 T1948 T1949 arg1Of sections,(
R1493 T1948 T1952 arg1Of sections,as
R1494 T1950 T1949 arg2Of 7 μm,(
R1495 T1951 T1949 arg3Of ),(
R1496 T1953 T1952 arg2Of described,as
R1497 T1953 T1954 arg1Of described,previously
R1498 T1953 T1955 arg1Of described,[
R1499 T1956 T1955 arg2Of 8,[
R1500 T1957 T1955 arg3Of ],[
R1501 T1959 T1958 arg1Of rats,Five
R1502 T1959 T1960 arg1Of rats,in
R1503 T1959 T1977 arg1Of rats,were
R1504 T1959 T1978 arg2Of rats,removed
R1505 T1959 T1980 arg2Of rats,stored
R1506 T1962 T1960 arg2Of group,in
R1507 T1962 T1961 arg1Of group,each
R1508 T1962 T1963 arg1Of group,at
R1509 T1965 T1963 arg2Of time,at
R1510 T1965 T1964 arg1Of time,each
R1511 T1966 T1967 arg1Of point,were
R1512 T1966 T1968 arg2Of point,sacrificed
R1513 T1968 T1965 arg2Of sacrificed,time
R1514 T1968 T1967 arg2Of sacrificed,were
R1515 T1972 T1968 arg1Of injection,sacrificed
R1516 T1972 T1969 arg2Of injection,by
R1517 T1972 T1970 arg1Of injection,over
R1518 T1972 T1971 arg1Of injection,dose
R1519 T1972 T1973 arg1Of injection,of
R1520 T1976 T1973 arg2Of brains,of
R1521 T1976 T1974 arg1Of brains,Ketamine.
R1522 T1976 T1975 arg1Of brains,The
R1523 T1978 T1979 arg1Of removed,and
R1524 T1979 T1977 arg2Of and,were
R1525 T1980 T1979 arg2Of stored,and
R1526 T1980 T1981 arg1Of stored,at
R1527 T1983 T1981 arg2Of 80°C,at
R1528 T1983 T1982 arg1Of 80°C,minus
R1529 T1983 T1984 arg1Of 80°C,for
R1530 T1985 T1986 arg1Of RT-PCR,and
R1531 T1986 T1984 arg2Of and,for
R1532 T1988 T1986 arg2Of Blots,and
R1533 T1988 T1987 arg1Of Blots,Western
R1763 T2255 T2256 arg1Of Induction,of
R1764 T2258 T2256 arg2Of Hemorrhage,of
R1765 T2258 T2257 arg1Of Hemorrhage,Intracerebral
R1766 T2262 T2260 arg1Of hemorrhages,most
R1767 T2262 T2261 arg1Of hemorrhages,intracerebral
R1768 T2262 T2263 arg1Of hemorrhages,occur
R1769 T2263 T2259 arg2Of occur,Since
R1770 T2263 T2264 arg1Of occur,in
R1771 T2267 T2264 arg2Of ganglia,in
R1772 T2267 T2265 arg1Of ganglia,the
R1773 T2267 T2266 arg1Of ganglia,basal
R1774 T2267 T2268 arg1Of ganglia,clinically
R1775 T2273 T2270 arg2Of study,in
R1776 T2273 T2271 arg1Of study,the
R1777 T2273 T2272 arg1Of study,present
R1778 T2276 T2275 arg1Of model,rat
R1779 T2276 T2277 arg1Of model,of
R1780 T2276 T2279 arg1Of model,was
R1781 T2276 T2280 arg2Of model,induced
R1782 T2278 T2277 arg2Of ICH,of
R1783 T2280 T2259 arg1Of induced,Since
R1784 T2280 T2269 arg1Of induced,","
R1785 T2280 T2270 arg1Of induced,in
R1786 T2280 T2274 arg1Of induced,","
R1787 T2280 T2279 arg2Of induced,was
R1788 T2280 T2281 arg1Of induced,in
R1789 T2284 T2281 arg2Of ganglia,in
R1790 T2284 T2282 arg1Of ganglia,left
R1791 T2284 T2283 arg1Of ganglia,basal
R1792 T2285 T2286 arg1Of Rats,were
R1793 T2285 T2287 arg2Of Rats,anesthetized
R1794 T2287 T2286 arg2Of anesthetized,were
R1795 T2287 T2288 arg1Of anesthetized,with
R1796 T2291 T2288 arg2Of pentobarbital,with
R1797 T2291 T2289 arg1Of pentobarbital,intra-peritoneal
R1798 T2291 T2290 arg1Of pentobarbital,sodium
R1799 T2291 T2292 arg1Of pentobarbital,(
R1800 T2293 T2292 arg2Of 60 mg/kg,(
R1801 T2294 T2292 arg3Of ),(
R1802 T2298 T2297 arg2Of rectal,(
R1803 T2299 T2297 arg3Of ),(
R1804 T2300 T2295 arg1Of temperature,The
R1805 T2300 T2296 arg1Of temperature,body
R1806 T2300 T2297 arg1Of temperature,(
R1807 T2300 T2301 arg1Of temperature,was
R1808 T2300 T2302 arg2Of temperature,maintained
R1809 T2302 T2301 arg2Of maintained,was
R1810 T2302 T2303 arg1Of maintained,at
R1811 T2302 T2305 arg1Of maintained,during
R1812 T2304 T2303 arg2Of 37°C,at
R1813 T2307 T2305 arg2Of surgery,during
R1814 T2307 T2306 arg1Of surgery,the
R1815 T2307 T2308 arg1Of surgery,using
R1816 T2312 T2308 arg2Of system,using
R1817 T2312 T2309 arg1Of system,a
R1818 T2312 T2310 arg1Of system,feedback-controlled
R1819 T2312 T2311 arg1Of system,heating
R1820 T2314 T2313 arg1Of rats,The
R1821 T2314 T2315 arg1Of rats,were
R1822 T2314 T2316 arg2Of rats,positioned
R1823 T2316 T2315 arg2Of positioned,were
R1824 T2316 T2317 arg1Of positioned,in
R1825 T2316 T2322 arg1Of positioned,and
R1826 T2320 T2317 arg2Of frame,in
R1827 T2320 T2318 arg1Of frame,a
R1828 T2320 T2319 arg1Of frame,stereotactic
R1829 T2322 T2321 arg1Of and,","
R1830 T2324 T2323 arg1Of scalp,the
R1831 T2324 T2325 arg1Of scalp,was
R1832 T2324 T2326 arg2Of scalp,incised
R1833 T2326 T2322 arg2Of incised,and
R1834 T2326 T2325 arg2Of incised,was
R1835 T2326 T2327 arg1Of incised,along
R1836 T2329 T2327 arg2Of midline,along
R1837 T2329 T2328 arg1Of midline,the
R1838 T2333 T2330 arg2Of technique,Using
R1839 T2333 T2331 arg1Of technique,a
R1840 T2333 T2332 arg1Of technique,sterile
R1841 T2338 T2330 arg1Of hole,Using
R1842 T2338 T2335 arg1Of hole,a
R1843 T2338 T2336 arg1Of hole,1 mm
R1844 T2338 T2337 arg1Of hole,burr
R1845 T2338 T2339 arg1Of hole,was
R1846 T2338 T2340 arg2Of hole,opened
R1847 T2340 T2330 modOf opened,Using
R1848 T2340 T2334 arg1Of opened,","
R1849 T2340 T2339 arg2Of opened,was
R1850 T2340 T2341 arg1Of opened,in
R1851 T2343 T2341 arg2Of skull,in
R1852 T2343 T2342 arg1Of skull,the
R1853 T2343 T2344 arg1Of skull,on
R1854 T2349 T2344 arg2Of 3 mm,on
R1855 T2349 T2345 arg1Of 3 mm,the
R1856 T2349 T2346 arg1Of 3 mm,left
R1857 T2349 T2347 arg1Of 3 mm,coronal
R1858 T2349 T2348 arg1Of 3 mm,suture
R1859 T2349 T2350 arg1Of 3 mm,lateral
R1860 T2350 T2351 arg1Of lateral,to
R1861 T2353 T2351 arg2Of midline,to
R1862 T2353 T2352 arg1Of midline,the
R1863 T2357 T2354 arg1Of needle,A
R1864 T2357 T2355 arg1Of needle,blunt
R1865 T2357 T2356 arg1Of needle,26-gauge
R1866 T2357 T2358 arg1Of needle,was
R1867 T2357 T2359 arg2Of needle,inserted
R1868 T2359 T2358 arg2Of inserted,was
R1869 T2359 T2360 arg1Of inserted,into
R1870 T2359 T2365 arg1Of inserted,under
R1871 T2364 T2360 arg2Of ganglia,into
R1872 T2364 T2361 arg1Of ganglia,the
R1873 T2364 T2362 arg1Of ganglia,left
R1874 T2364 T2363 arg1Of ganglia,basal
R1875 T2367 T2365 arg2Of guidance,under
R1876 T2367 T2366 arg1Of guidance,stereotactic
R1877 T2367 T2368 arg1Of guidance,(
R1878 T2369 T2368 arg2Of coordinates,(
R1879 T2370 T2368 arg3Of :,(
R1880 T2371 T2372 arg1Of 0.2 mm,anterior
R1881 T2371 T2375 arg1Of 0.2 mm,ventral
R1882 T2371 T2377 arg1Of 0.2 mm,and
R1883 T2372 T2373 arg1Of anterior,","
R1884 T2375 T2373 arg2Of ventral,","
R1885 T2375 T2374 arg1Of ventral,6.0 mm
R1886 T2377 T2376 arg1Of and,","
R1887 T2378 T2377 arg2Of 3.0 mm,and
R1888 T2378 T2379 arg1Of 3.0 mm,lateral
R1889 T2379 T2380 arg1Of lateral,to
R1890 T2382 T2380 arg2Of midline,to
R1891 T2382 T2381 arg1Of midline,the
R1892 T2382 T2383 arg1Of midline,)
R1893 T2387 T2386 arg1Of 75 μL,a
R1894 T2387 T2388 arg1Of 75 μL,of
R1895 T2387 T2392 arg1Of 75 μL,was
R1896 T2387 T2393 arg2Of 75 μL,infused
R1897 T2391 T2388 arg2Of blood,of
R1898 T2391 T2389 arg1Of blood,autologous
R1899 T2391 T2390 arg1Of blood,whole
R1900 T2393 T2384 arg1Of infused,Then
R1901 T2393 T2385 arg1Of infused,","
R1902 T2393 T2392 arg2Of infused,was
R1903 T2393 T2394 arg1Of infused,at
R1904 T2396 T2394 arg2Of rate,at
R1905 T2396 T2395 arg1Of rate,a
R1906 T2396 T2397 arg1Of rate,of
R1907 T2396 T2399 arg1Of rate,with
R1908 T2398 T2397 arg2Of 20 μL/min,of
R1909 T2401 T2399 arg2Of use,with
R1910 T2401 T2400 arg1Of use,the
R1911 T2401 T2402 arg1Of use,of
R1912 T2405 T2402 arg2Of pump,of
R1913 T2405 T2403 arg1Of pump,a
R1914 T2405 T2404 arg1Of pump,microinfusion
R1915 T2408 T2406 arg2Of completion,After
R1916 T2408 T2407 arg1Of completion,the
R1917 T2408 T2409 arg1Of completion,of
R1918 T2411 T2409 arg2Of infusion,of
R1919 T2411 T2410 arg1Of infusion,the
R1920 T2414 T2413 arg1Of needle,the
R1921 T2414 T2415 arg1Of needle,was
R1922 T2414 T2416 arg2Of needle,withdrawn
R1923 T2416 T2415 arg2Of withdrawn,was
R1924 T2416 T2417 arg1Of withdrawn,quickly
R1925 T2420 T2419 arg1Of glue,cyanoacrylate
R1926 T2420 T2421 arg1Of glue,was
R1927 T2420 T2422 arg2Of glue,placed
R1928 T2422 T2421 arg2Of placed,was
R1929 T2422 T2423 arg1Of placed,around
R1930 T2422 T2428 arg1Of placed,and
R1931 T2426 T2423 arg2Of hole,around
R1932 T2426 T2424 arg1Of hole,the
R1933 T2426 T2425 arg1Of hole,burr
R1934 T2428 T2406 arg1Of and,After
R1935 T2428 T2412 arg1Of and,","
R1936 T2428 T2415 modOf and,was
R1937 T2428 T2418 arg1Of and,","
R1938 T2428 T2427 arg1Of and,","
R1939 T2431 T2429 arg1Of incision,the
R1940 T2431 T2430 arg1Of incision,skin
R1941 T2431 T2432 arg1Of incision,was
R1942 T2431 T2433 arg2Of incision,closed
R1943 T2433 T2428 arg2Of closed,and
R1944 T2433 T2432 arg2Of closed,was
R1945 T2433 T2434 arg1Of closed,with
R1946 T2435 T2434 arg2Of sutures,with
R1947 T2441 T2436 arg2Of rats,For
R1948 T2441 T2437 arg1Of rats,the
R1949 T2441 T2438 arg1Of rats,normal
R1950 T2441 T2439 arg1Of rats,saline
R1951 T2441 T2440 arg1Of rats,control
R1952 T2446 T2443 arg1Of saline,only
R1953 T2446 T2444 arg1Of saline,75 μL
R1954 T2446 T2445 arg1Of saline,normal
R1955 T2446 T2447 arg1Of saline,was
R1956 T2446 T2448 arg2Of saline,injected
R1957 T2448 T2436 arg1Of injected,For
R1958 T2448 T2442 arg1Of injected,","
R1959 T2448 T2447 arg2Of injected,was
R2188 T2817 T2818 arg1Of Detection,of
R2189 T2817 T2821 arg1Of Detection,by
R2190 T2820 T2818 arg2Of mRNA,of
R2191 T2820 T2819 arg1Of mRNA,TLR4
R2192 T2823 T2821 arg2Of Method,by
R2193 T2823 T2822 arg1Of Method,the
R2194 T2823 T2824 arg1Of Method,of
R2195 T2825 T2824 arg2Of RT-PCR,of
R2196 T2830 T2828 arg1Of samples,total
R2197 T2830 T2829 arg1Of samples,RNA
R2198 T2830 T2831 arg1Of samples,were
R2199 T2830 T2832 arg2Of samples,isolated
R2200 T2832 T2826 arg1Of isolated,Briefly
R2201 T2832 T2827 arg1Of isolated,","
R2202 T2832 T2831 arg2Of isolated,were
R2203 T2832 T2833 arg1Of isolated,from
R2204 T2835 T2833 arg2Of regions,from
R2205 T2835 T2834 arg1Of regions,peri-hemorrhage
R2206 T2835 T2836 arg1Of regions,in
R2207 T2839 T2836 arg2Of ganglia,in
R2208 T2839 T2837 arg1Of ganglia,left
R2209 T2839 T2838 arg1Of ganglia,basal
R2210 T2839 T2840 arg1Of ganglia,using
R2211 T2840 T2847 arg1Of using,(
R2212 T2840 T2854 arg1Of using,according
R2213 T2843 T2841 arg1Of Total,Simply
R2214 T2843 T2842 arg1Of Total,P
R2215 T2846 T2840 arg2Of Kit,using
R2216 T2846 T2843 arg1Of Kit,Total
R2217 T2846 T2844 arg1Of Kit,RNA
R2218 T2846 T2845 arg1Of Kit,isolation
R2219 T2848 T2849 arg1Of BioFlux,","
R2220 T2849 T2847 arg2Of ",",(
R2221 T2849 T2851 arg1Of ",",","
R2222 T2850 T2849 arg2Of HZ,","
R2223 T2852 T2851 arg2Of China,","
R2224 T2853 T2847 arg3Of ),(
R2225 T2855 T2854 arg2Of to,according
R2226 T2857 T2856 arg1Of manufacturer,the
R2227 T2857 T2858 arg2Of manufacturer,'s
R2228 T2859 T2855 arg2Of instructions,to
R2229 T2859 T2858 arg1Of instructions,'s
R2230 T2861 T2860 arg1Of quantity,The
R2231 T2861 T2862 arg1Of quantity,of
R2232 T2861 T2865 arg1Of quantity,was
R2233 T2861 T2866 arg2Of quantity,determined
R2234 T2861 T2875 arg1Of quantity,measuring
R2235 T2864 T2862 arg2Of RNA,of
R2236 T2864 T2863 arg1Of RNA,total
R2237 T2866 T2865 arg2Of determined,was
R2238 T2866 T2867 arg1Of determined,on
R2239 T2866 T2874 arg1Of determined,by
R2240 T2869 T2867 arg2Of Nanodrop,on
R2241 T2869 T2868 arg1Of Nanodrop,a
R2242 T2869 T2870 arg1Of Nanodrop,(
R2243 T2872 T2870 arg2Of Spectrophotometer,(
R2244 T2872 T2871 arg1Of Spectrophotometer,ND-1000
R2245 T2873 T2870 arg3Of ),(
R2246 T2875 T2874 arg2Of measuring,by
R2247 T2875 T2878 arg1Of measuring,at
R2248 T2877 T2875 arg2Of density,measuring
R2249 T2877 T2876 arg1Of density,optical
R2250 T2879 T2880 arg1Of A260,and
R2251 T2881 T2880 arg2Of A280 nm,and
R2252 T2882 T2878 arg2Of wavelength,at
R2253 T2882 T2879 arg1Of wavelength,A260
R2254 T2882 T2881 arg1Of wavelength,A280 nm
R2255 T2886 T2885 arg1Of concentrations,the
R2256 T2886 T2887 arg1Of concentrations,of
R2257 T2886 T2889 arg1Of concentrations,were
R2258 T2886 T2890 arg2Of concentrations,adjusted
R2259 T2888 T2887 arg2Of mRNA,of
R2260 T2890 T2883 arg1Of adjusted,Then
R2261 T2890 T2884 arg1Of adjusted,","
R2262 T2890 T2889 arg2Of adjusted,were
R2263 T2890 T2891 arg1Of adjusted,to
R2264 T2892 T2891 arg2Of 1.0 g/mL,to
R2265 T2893 T2894 arg1Of RNA,was
R2266 T2893 T2895 arg2Of RNA,reverse-transcribed
R2267 T2893 T2902 arg1Of RNA,using
R2268 T2895 T2894 arg2Of reverse-transcribed,was
R2269 T2895 T2896 arg1Of reverse-transcribed,into
R2270 T2895 T2898 arg1Of reverse-transcribed,in
R2271 T2895 T2902 modOf reverse-transcribed,using
R2272 T2897 T2896 arg2Of cDNA,into
R2273 T2901 T2898 arg2Of system,in
R2274 T2901 T2899 arg1Of system,20 μL
R2275 T2901 T2900 arg1Of system,reaction
R2276 T2905 T2903 arg1Of Synthesis,Superscript
R2277 T2905 T2904 arg1Of Synthesis,First-Strand
R2278 T2906 T2902 arg2Of Kit,using
R2279 T2906 T2905 arg1Of Kit,Synthesis
R2280 T2906 T2907 arg1Of Kit,for
R2281 T2908 T2907 arg2Of RT-PCR,for
R2282 T2908 T2909 arg1Of RT-PCR,(
R2283 T2908 T2913 arg1Of RT-PCR,under
R2284 T2911 T2909 arg2Of Inc,(
R2285 T2911 T2910 arg1Of Inc,promega
R2286 T2912 T2909 arg3Of ),(
R2287 T2914 T2913 arg2Of conditions,under
R2288 T2914 T2915 arg2Of conditions,described
R2289 T2918 T2915 arg1Of supplier,described
R2290 T2918 T2916 arg2Of supplier,by
R2291 T2918 T2917 arg1Of supplier,the
R2292 T2920 T2919 arg1Of microliter,One
R2293 T2920 T2921 arg1Of microliter,of
R2294 T2920 T2923 arg1Of microliter,was
R2295 T2920 T2924 arg2Of microliter,used
R2296 T2922 T2921 arg2Of cDNA,of
R2297 T2924 T2923 arg2Of used,was
R2298 T2926 T2924 arg3Of amplify,used
R2299 T2926 T2925 arg1Of amplify,to
R2300 T2930 T2926 arg2Of fragment,amplify
R2301 T2930 T2927 arg1Of fragment,the
R2302 T2930 T2928 arg1Of fragment,TLR4
R2303 T2930 T2929 arg1Of fragment,gene
R2304 T2930 T2931 arg1Of fragment,with
R2305 T2934 T2932 arg1Of buffer,1×
R2306 T2934 T2933 arg1Of buffer,PCR
R2307 T2934 T2935 arg1Of buffer,","
R2308 T2935 T2937 arg1Of ",",","
R2309 T2936 T2935 arg2Of 1.5 mM MgCl2,","
R2310 T2937 T2942 arg1Of ",",","
R2311 T2938 T2937 arg2Of 200 μM,","
R2312 T2938 T2939 arg1Of 200 μM,of
R2313 T2941 T2939 arg2Of dNTP,of
R2314 T2941 T2940 arg1Of dNTP,each
R2315 T2942 T2947 arg1Of ",",and
R2316 T2943 T2942 arg2Of 200 μM,","
R2317 T2943 T2944 arg1Of 200 μM,of
R2318 T2945 T2944 arg2Of primers,of
R2319 T2947 T2931 arg2Of and,with
R2320 T2947 T2946 arg1Of and,","
R2321 T2951 T2947 arg2Of polymerase,and
R2322 T2951 T2948 arg1Of polymerase,2u
R2323 T2951 T2949 arg1Of polymerase,Taq
R2324 T2951 T2950 arg1Of polymerase,DNA
R2325 T2955 T2952 arg1Of gene,The
R2326 T2955 T2953 arg1Of gene,house
R2327 T2955 T2954 arg1Of gene,keep
R2328 T2955 T2956 arg1Of gene,(
R2329 T2955 T2959 arg1Of gene,was
R2330 T2955 T2960 arg2Of gene,used
R2331 T2957 T2956 arg2Of β-actin,(
R2332 T2958 T2956 arg3Of ),(
R2333 T2960 T2959 arg2Of used,was
R2334 T2960 T2961 arg1Of used,as
R2335 T2964 T2961 arg2Of control,as
R2336 T2964 T2962 arg1Of control,an
R2337 T2964 T2963 arg1Of control,internal
R2338 T2968 T2965 arg1Of sequences,The
R2339 T2968 T2966 arg1Of sequences,PCR
R2340 T2968 T2967 arg1Of sequences,primer
R2341 T2968 T2969 arg1Of sequences,were
R2342 T2968 T2970 arg2Of sequences,designed
R2343 T2970 T2969 arg2Of designed,were
R2344 T2970 T2971 arg1Of designed,according
R2345 T2972 T2971 arg2Of to,according
R2346 T2974 T2975 arg1Of TLR4,and
R2347 T2975 T2972 arg2Of and,to
R2348 T2975 T2973 arg1Of and,the
R2349 T2975 T2979 arg2Of and,reported
R2350 T2978 T2975 arg2Of sequences,and
R2351 T2978 T2976 arg1Of sequences,β-actin
R2352 T2978 T2977 arg1Of sequences,gene
R2353 T2979 T2980 arg1Of reported,in
R2354 T2981 T2980 arg2Of GenBank,in
R2355 T2982 T2983 arg1Of TLR4,(
R2356 T2982 T2986 arg1Of TLR4,:
R2357 T2982 T2987 arg1Of TLR4,forward
R2358 T2982 T2988 arg1Of TLR4,:
R2359 T2984 T2983 arg2Of 145 bp,(
R2360 T2985 T2983 arg3Of ),(
R2361 T2989 T2990 arg1Of 5′-AGCTTTGGTCAGTTGGCTCT-3′,;
R2362 T2990 T2992 arg1Of ;,:
R2363 T2991 T2990 arg2Of reverse,;
R2364 T2993 T2994 arg1Of 5′-CAGGATGACACCATTGAAGC-3′,;
R2365 T2994 T2996 arg1Of ;,(
R2366 T2994 T2999 arg1Of ;,:
R2367 T2994 T3000 arg1Of ;,forward
R2368 T2994 T3001 arg1Of ;,:
R2369 T2995 T2994 arg2Of β-actin,;
R2370 T2997 T2996 arg2Of 701 bp,(
R2371 T2998 T2996 arg3Of ),(
R2372 T3002 T3003 arg1Of 5′-GCCAACCGTGAAAAAGATG-3′,;
R2373 T3003 T3005 arg1Of ;,:
R2374 T3004 T3003 arg2Of reverse,;
R2375 T3008 T3007 arg1Of cycles,Reaction
R2376 T3008 T3009 arg1Of cycles,were
R2377 T3008 T3010 arg2Of cycles,performed
R2378 T3010 T3009 arg2Of performed,were
R2379 T3010 T3011 arg1Of performed,at
R2380 T3010 T3015 arg1Of performed,:
R2381 T3014 T3011 arg2Of condition,at
R2382 T3014 T3012 arg1Of condition,the
R2383 T3014 T3013 arg1Of condition,following
R2384 T3017 T3016 arg1Of 2 min,94°C
R2385 T3017 T3018 arg1Of 2 min,","
R2386 T3018 T3021 arg1Of ",",","
R2387 T3020 T3018 arg2Of 40 s,","
R2388 T3020 T3019 arg1Of 40 s,94°C
R2389 T3021 T3025 arg1Of ",",and
R2390 T3023 T3021 arg2Of 40 s,","
R2391 T3023 T3022 arg1Of 40 s,55°C
R2392 T3025 T3024 arg1Of and,","
R2393 T3027 T3025 arg2Of 60 s,and
R2394 T3027 T3026 arg1Of 60 s,72°C
R2395 T3029 T3028 arg1Of reaction,The
R2396 T3029 T3030 arg1Of reaction,was
R2397 T3029 T3031 arg2Of reaction,stopped
R2398 T3031 T3030 arg2Of stopped,was
R2399 T3031 T3032 arg1Of stopped,after
R2400 T3034 T3032 arg2Of cycles,after
R2401 T3034 T3033 arg1Of cycles,31
R2402 T3036 T3035 arg1Of products,PCR
R2403 T3036 T3037 arg1Of products,were
R2404 T3036 T3038 arg2Of products,electrophoresed
R2405 T3038 T3037 arg2Of electrophoresed,were
R2406 T3038 T3039 arg1Of electrophoresed,through
R2407 T3041 T3039 arg2Of gel,through
R2408 T3041 T3040 arg1Of gel,agarose
R2409 T3043 T3042 arg1Of Acquisition,Image
R2410 T3043 T3044 arg1Of Acquisition,and
R2411 T3044 T3047 arg1Of and,were
R2412 T3044 T3048 arg2Of and,used
R2413 T3046 T3044 arg2Of software,and
R2414 T3046 T3045 arg1Of software,Analysis
R2415 T3048 T3047 arg2Of used,were
R2416 T3048 T3049 modOf used,to
R2417 T3050 T3049 arg1Of determine,to
R2418 T3052 T3050 arg2Of densities,determine
R2419 T3052 T3051 arg1Of densities,band
R2420 T3054 T3053 arg1Of abundance,The
R2421 T3054 T3055 arg1Of abundance,of
R2422 T3054 T3058 arg1Of abundance,was
R2423 T3054 T3059 arg2Of abundance,expressed
R2424 T3057 T3055 arg2Of mRNA,of
R2425 T3057 T3056 arg1Of mRNA,TLR4
R2426 T3059 T3058 arg2Of expressed,was
R2427 T3059 T3060 arg1Of expressed,as
R2428 T3062 T3060 arg2Of ratio,as
R2429 T3062 T3061 arg1Of ratio,the
R2430 T3062 T3063 arg1Of ratio,of
R2431 T3062 T3066 arg1Of ratio,to
R2432 T3065 T3063 arg2Of mRNA,of
R2433 T3065 T3064 arg1Of mRNA,TLR4
R2434 T3068 T3066 arg2Of mRNA,to
R2435 T3068 T3067 arg1Of mRNA,β-actin
R2754 T3542 T3543 arg1Of Immunohistochemistry,(
R2755 T3544 T3543 arg2Of IHC,(
R2756 T3545 T3543 arg3Of ),(
R2757 T3548 T3546 arg1Of staining,The
R2758 T3548 T3547 arg1Of staining,IHC
R2759 T3548 T3549 arg1Of staining,for
R2760 T3548 T3551 arg1Of staining,was
R2761 T3548 T3552 arg2Of staining,performed
R2762 T3550 T3549 arg2Of TLR4,for
R2763 T3552 T3551 arg2Of performed,was
R2764 T3552 T3553 arg1Of performed,as
R2765 T3552 T3556 arg1Of performed,[
R2766 T3554 T3553 arg2Of described,as
R2767 T3554 T3555 arg1Of described,previously
R2768 T3557 T3556 arg2Of 8,[
R2769 T3558 T3556 arg3Of ],[
R2770 T3561 T3559 arg1Of antibody,The
R2771 T3561 T3560 arg1Of antibody,primary
R2772 T3561 T3562 arg2Of antibody,employed
R2773 T3561 T3563 arg1Of antibody,was
R2774 T3563 T3566 arg1Of was,(
R2775 T3565 T3563 arg2Of anti-TLR4,was
R2776 T3565 T3564 arg1Of anti-TLR4,rabbit
R2777 T3567 T3566 arg2Of WuHan,(
R2778 T3567 T3568 arg1Of WuHan,","
R2779 T3567 T3569 arg1Of WuHan,BA1717
R2780 T3570 T3566 arg3Of ),(
R2781 T3574 T3571 arg1Of antibody,The
R2782 T3574 T3572 arg2Of antibody,biotinylated
R2783 T3574 T3573 arg1Of antibody,secondary
R2784 T3574 T3575 arg1Of antibody,and
R2785 T3575 T3584 arg1Of and,were
R2786 T3575 T3585 arg2Of and,obtained
R2787 T3577 T3575 arg2Of complexes,and
R2788 T3577 T3576 arg1Of complexes,antibody-biotin-avidin-peroxidase
R2789 T3577 T3578 arg1Of complexes,(
R2790 T3580 T3578 arg2Of reagent,(
R2791 T3580 T3579 arg1Of reagent,ABC
R2792 T3580 T3581 arg1Of reagent,","
R2793 T3582 T3581 arg2Of SC-2018,","
R2794 T3583 T3578 arg3Of ),(
R2795 T3585 T3584 arg2Of obtained,were
R2796 T3585 T3586 arg1Of obtained,from
R2797 T3590 T3586 arg2Of Inc.,from
R2798 T3590 T3587 arg1Of Inc.,Santa
R2799 T3590 T3588 arg1Of Inc.,Cruz
R2800 T3590 T3589 arg1Of Inc.,Biotechnology
R2801 T3590 T3591 arg1Of Inc.,(
R2802 T3593 T3591 arg2Of Cruz,(
R2803 T3593 T3592 arg1Of Cruz,Santa
R2804 T3593 T3594 arg1Of Cruz,","
R2805 T3595 T3594 arg2Of CA,","
R2806 T3596 T3591 arg3Of ),(
R2807 T3597 T3598 arg2Of Slides,processed
R2808 T3598 T3599 arg1Of processed,without
R2809 T3601 T3599 arg2Of antibodies,without
R2810 T3601 T3600 arg1Of antibodies,primary
R2811 T3601 T3602 arg2Of antibodies,served
R2812 T3602 T3603 arg1Of served,as
R2813 T3605 T3603 arg2Of controls,as
R2814 T3605 T3604 arg1Of controls,negative
R2889 T3746 T3745 arg1Of Blots,Western
R2890 T3748 T3747 arg1Of proteins,Cellular
R2891 T3748 T3749 arg1Of proteins,were
R2892 T3748 T3750 arg2Of proteins,prepared
R2893 T3750 T3749 arg2Of prepared,were
R2894 T3750 T3751 arg1Of prepared,from
R2895 T3754 T3751 arg2Of hemispheres,from
R2896 T3754 T3752 arg1Of hemispheres,ICH
R2897 T3754 T3753 arg1Of hemispheres,cerebral
R2898 T3754 T3755 arg1Of hemispheres,","
R2899 T3754 T3756 arg2Of hemispheres,electrophoresed
R2900 T3754 T3761 arg2Of hemispheres,transferred
R2901 T3754 T3766 arg1Of hemispheres,(
R2902 T3756 T3757 arg1Of electrophoresed,with
R2903 T3756 T3760 arg1Of electrophoresed,and
R2904 T3759 T3757 arg2Of gel,with
R2905 T3759 T3758 arg1Of gel,SDS-polyacrylamide
R2906 T3761 T3760 arg2Of transferred,and
R2907 T3761 T3762 arg1Of transferred,onto
R2908 T3765 T3762 arg2Of membranes,onto
R2909 T3765 T3763 arg1Of membranes,Hybond
R2910 T3765 T3764 arg1Of membranes,ECL
R2911 T3768 T3766 arg2Of Pharmacia,(
R2912 T3768 T3767 arg1Of Pharmacia,Amersham
R2913 T3768 T3769 arg1Of Pharmacia,","
R2914 T3770 T3769 arg2Of Piscataway,","
R2915 T3770 T3771 arg1Of Piscataway,","
R2916 T3772 T3771 arg2Of NJ,","
R2917 T3773 T3766 arg3Of ),(
R2918 T3776 T3774 arg1Of membranes,The
R2919 T3776 T3775 arg1Of membranes,ECL
R2920 T3776 T3777 arg1Of membranes,were
R2921 T3776 T3778 arg2Of membranes,incubated
R2922 T3778 T3777 arg2Of incubated,were
R2923 T3778 T3779 arg1Of incubated,with
R2924 T3783 T3779 arg2Of antibody,with
R2925 T3783 T3780 arg1Of antibody,the
R2926 T3783 T3781 arg1Of antibody,appropriate
R2927 T3783 T3782 arg1Of antibody,primary
R2928 T3783 T3784 arg1Of antibody,(
R2929 T3783 T3789 arg2Of antibody,followed
R2930 T3785 T3784 arg2Of WuHan,(
R2931 T3785 T3786 arg1Of WuHan,","
R2932 T3787 T3786 arg2Of BA1717,","
R2933 T3788 T3784 arg3Of ),(
R2934 T3791 T3789 arg1Of incubation,followed
R2935 T3791 T3790 arg2Of incubation,by
R2936 T3791 T3792 arg1Of incubation,with
R2937 T3795 T3792 arg2Of antibodies,with
R2938 T3795 T3793 arg1Of antibodies,peroxidase-conjugated
R2939 T3795 T3794 arg1Of antibodies,secondary
R2940 T3795 T3796 arg1Of antibodies,(
R2941 T3798 T3796 arg2Of Bridge,(
R2942 T3798 T3797 arg1Of Bridge,Golden
R2943 T3798 T3799 arg1Of Bridge,","
R2944 T3800 T3799 arg2Of PV-6001,","
R2945 T3801 T3796 arg3Of ),(
R2946 T3803 T3802 arg1Of signals,The
R2947 T3803 T3804 arg1Of signals,were
R2948 T3803 T3805 arg2Of signals,detected
R2949 T3805 T3804 arg2Of detected,were
R2950 T3805 T3806 arg1Of detected,with
R2951 T3809 T3806 arg2Of system,with
R2952 T3809 T3807 arg1Of system,the
R2953 T3809 T3808 arg1Of system,ECL
R2954 T3809 T3810 arg1Of system,(
R2955 T3812 T3810 arg2Of Pharmacia,(
R2956 T3812 T3811 arg1Of Pharmacia,Amersham
R2957 T3813 T3810 arg3Of ),(
R2958 T3816 T3814 arg1Of membranes,The
R2959 T3816 T3815 arg1Of membranes,same
R2960 T3816 T3817 arg1Of membranes,were
R2961 T3816 T3818 arg2Of membranes,probed
R2962 T3816 T3832 arg1Of membranes,being
R2963 T3816 T3833 arg2Of membranes,washed
R2964 T3818 T3817 arg2Of probed,were
R2965 T3818 T3819 arg1Of probed,with
R2966 T3818 T3831 arg1Of probed,after
R2967 T3820 T3819 arg2Of anti-GAPDH,with
R2968 T3820 T3821 arg1Of anti-GAPDH,(
R2969 T3823 T3821 arg2Of dehydrogenase,(
R2970 T3823 T3822 arg1Of dehydrogenase,glyceraldehyde-3-phosphate
R2971 T3823 T3824 arg1Of dehydrogenase,","
R2972 T3823 T3828 arg1Of dehydrogenase,","
R2973 T3823 T3829 arg1Of dehydrogenase,Maine
R2974 T3825 T3826 arg1Of Biodesign,","
R2975 T3826 T3824 arg2Of ",",","
R2976 T3827 T3826 arg2Of Saco,","
R2977 T3830 T3821 arg3Of ),(
R2978 T3833 T3831 arg2Of washed,after
R2979 T3833 T3832 arg2Of washed,being
R2980 T3833 T3834 arg1Of washed,with
R2981 T3835 T3834 arg2Of stripping,with
R2982 T3836 T3835 arg2Of buffer,stripping
R2983 T3838 T3837 arg1Of signals,The
R2984 T3838 T3839 arg1Of signals,were
R2985 T3838 T3840 arg2Of signals,quantified
R2986 T3840 T3839 arg2Of quantified,were
R2987 T3840 T3841 arg1Of quantified,by
R2988 T3842 T3841 arg2Of scanning,by
R2989 T3843 T3844 arg1Of densitometry,and
R2990 T3844 T3842 arg2Of and,scanning
R2991 T3847 T3844 arg2Of analysis,and
R2992 T3847 T3845 arg1Of analysis,computer-assisted
R2993 T3847 T3846 arg1Of analysis,image
R3109 T4038 T4035 arg1Of Assay,Electrophoretic
R3110 T4038 T4036 arg1Of Assay,Mobility
R3111 T4038 T4037 arg1Of Assay,Shift
R3112 T4038 T4039 arg1Of Assay,(
R3113 T4040 T4039 arg2Of EMSA,(
R3114 T4041 T4039 arg3Of ),(
R3115 T4043 T4042 arg1Of proteins,Nuclear
R3116 T4043 T4044 arg1Of proteins,were
R3117 T4043 T4045 arg2Of proteins,isolated
R3118 T4045 T4044 arg2Of isolated,were
R3119 T4045 T4046 arg1Of isolated,from
R3120 T4048 T4046 arg2Of tissue,from
R3121 T4048 T4047 arg1Of tissue,brain
R3122 T4052 T4051 arg2Of removal,after
R3123 T4052 T4053 arg1Of removal,of
R3124 T4054 T4053 arg2Of supernatant,of
R3125 T4054 T4055 arg1Of supernatant,(
R3126 T4057 T4055 arg2Of extract,(
R3127 T4057 T4056 arg1Of extract,cytoplasmic
R3128 T4058 T4055 arg3Of ),(
R3129 T4061 T4060 arg1Of pellets,the
R3130 T4061 T4062 arg1Of pellets,were
R3131 T4061 T4063 arg2Of pellets,resuspended
R3132 T4063 T4049 arg1Of resuspended,Briefly
R3133 T4063 T4050 arg1Of resuspended,","
R3134 T4063 T4051 arg1Of resuspended,after
R3135 T4063 T4059 arg1Of resuspended,","
R3136 T4063 T4062 arg2Of resuspended,were
R3137 T4063 T4064 arg1Of resuspended,in
R3138 T4067 T4064 arg2Of reagent,in
R3139 T4067 T4065 arg1Of reagent,nuclear
R3140 T4067 T4066 arg1Of reagent,extraction
R3141 T4069 T4068 arg1Of tubes,The
R3142 T4069 T4070 arg1Of tubes,containing
R3143 T4069 T4072 arg1Of tubes,were
R3144 T4069 T4073 arg2Of tubes,put
R3145 T4071 T4070 arg2Of pellets,containing
R3146 T4073 T4072 arg2Of put,were
R3147 T4073 T4074 arg1Of put,on
R3148 T4073 T4076 arg1Of put,for
R3149 T4073 T4081 arg1Of put,minutes
R3150 T4073 T4082 arg1Of put,","
R3151 T4073 T4083 arg1Of put,for
R3152 T4075 T4074 arg2Of vortex,on
R3153 T4078 T4076 arg2Of seconds,for
R3154 T4078 T4077 arg1Of seconds,15
R3155 T4081 T4079 arg1Of minutes,every
R3156 T4081 T4080 arg1Of minutes,10
R3157 T4085 T4083 arg2Of total,for
R3158 T4085 T4084 arg1Of total,a
R3159 T4085 T4086 arg1Of total,of
R3160 T4088 T4086 arg2Of minutes,of
R3161 T4088 T4087 arg1Of minutes,40
R3162 T4090 T4089 arg1Of tubes,The
R3163 T4090 T4091 arg1Of tubes,were
R3164 T4090 T4092 arg2Of tubes,centrifuged
R3165 T4092 T4091 arg2Of centrifuged,were
R3166 T4092 T4093 arg1Of centrifuged,at
R3167 T4095 T4093 arg2Of speed,at
R3168 T4095 T4094 arg1Of speed,maximum
R3169 T4095 T4096 arg1Of speed,(
R3170 T4095 T4100 arg1Of speed,in
R3171 T4098 T4096 arg2Of × g,(
R3172 T4098 T4097 arg1Of × g,"~16,000"
R3173 T4099 T4096 arg3Of ),(
R3174 T4103 T4100 arg2Of centrifuge,in
R3175 T4103 T4101 arg1Of centrifuge,a
R3176 T4103 T4102 arg1Of centrifuge,micro
R3177 T4103 T4104 arg1Of centrifuge,for
R3178 T4106 T4104 arg2Of minutes,for
R3179 T4106 T4105 arg1Of minutes,10
R3180 T4108 T4107 arg1Of supernatants,The
R3181 T4108 T4109 arg1Of supernatants,(
R3182 T4108 T4113 arg1Of supernatants,were
R3183 T4108 T4114 arg2Of supernatants,transferred
R3184 T4108 T4121 arg2Of supernatants,stored
R3185 T4111 T4109 arg2Of extract,(
R3186 T4111 T4110 arg1Of extract,nuclear
R3187 T4112 T4109 arg3Of ),(
R3188 T4114 T4115 arg1Of transferred,to
R3189 T4114 T4120 arg1Of transferred,and
R3190 T4119 T4115 arg2Of tube,to
R3191 T4119 T4116 arg1Of tube,a
R3192 T4119 T4117 arg1Of tube,clean
R3193 T4119 T4118 arg1Of tube,prechilled
R3194 T4120 T4113 arg2Of and,were
R3195 T4121 T4120 arg2Of stored,and
R3196 T4121 T4122 arg1Of stored,at
R3197 T4121 T4124 arg1Of stored,until
R3198 T4123 T4122 arg2Of −80°C,at
R3199 T4125 T4124 arg2Of use,until
R3200 T4126 T4127 arg1Of EMSA,was
R3201 T4126 T4128 arg2Of EMSA,performed
R3202 T4128 T4127 arg2Of performed,was
R3203 T4128 T4129 arg1Of performed,as
R3204 T4128 T4132 arg1Of performed,[
R3205 T4130 T4129 arg2Of described,as
R3206 T4130 T4131 arg1Of described,previously
R3207 T4133 T4132 arg2Of 8,[
R3208 T4134 T4132 arg3Of ],[
R3209 T4137 T4135 arg1Of activity,NFκB
R3210 T4137 T4136 arg1Of activity,binding
R3211 T4137 T4138 arg1Of activity,was
R3212 T4137 T4139 arg2Of activity,examined
R3213 T4139 T4138 arg2Of examined,was
R3214 T4139 T4140 arg1Of examined,in
R3215 T4145 T4140 arg2Of mixture,in
R3216 T4145 T4141 arg1Of mixture,a
R3217 T4145 T4142 arg1Of mixture,15 μL
R3218 T4145 T4143 arg1Of mixture,binding
R3219 T4145 T4144 arg1Of mixture,reaction
R3220 T4145 T4146 arg1Of mixture,containing
R3221 T4147 T4148 arg1Of 15 μg,of
R3222 T4147 T4151 arg1Of 15 μg,and
R3223 T4150 T4148 arg2Of proteins,of
R3224 T4150 T4149 arg1Of proteins,nuclear
R3225 T4151 T4146 arg2Of and,containing
R3226 T4152 T4153 arg1Of 35 fmol,[
R3227 T4154 T4153 arg2Of γ-32P,[
R3228 T4155 T4153 arg3Of ],[
R3229 T4160 T4151 arg2Of oligonucleotide,and
R3230 T4160 T4152 arg1Of oligonucleotide,35 fmol
R3231 T4160 T4156 arg2Of oligonucleotide,labeled
R3232 T4160 T4157 arg1Of oligonucleotide,double-stranded
R3233 T4160 T4158 arg1Of oligonucleotide,NFκB
R3234 T4160 T4159 arg1Of oligonucleotide,consensus
R3235 T4164 T4161 arg1Of assay,A
R3236 T4164 T4162 arg1Of assay,super
R3237 T4164 T4163 arg1Of assay,shift
R3238 T4164 T4165 arg1Of assay,using
R3239 T4164 T4171 arg1Of assay,was
R3240 T4164 T4172 arg2Of assay,performed
R3241 T4166 T4165 arg2Of antibodies,using
R3242 T4166 T4167 arg1Of antibodies,to
R3243 T4168 T4169 arg1Of P65,and
R3244 T4169 T4167 arg2Of and,to
R3245 T4170 T4169 arg2Of P50,and
R3246 T4172 T4171 arg2Of performed,was
R3247 T4172 T4173 modOf performed,to
R3248 T4174 T4173 arg1Of confirm,to
R3249 T4177 T4174 arg2Of specificity,confirm
R3250 T4177 T4175 arg1Of specificity,NFκB
R3251 T4177 T4176 arg1Of specificity,binding
R3252 T4177 T4178 arg1Of specificity,as
R3253 T4180 T4178 arg2Of described,as
R3254 T4180 T4179 arg1Of described,previously
R3420 T4387 T4386 arg1Of Analysis,Statistical
R3421 T4389 T4388 arg1Of data,All
R3422 T4389 T4390 arg1Of data,were
R3423 T4389 T4391 arg2Of data,presented
R3424 T4391 T4390 arg2Of presented,were
R3425 T4391 T4392 arg1Of presented,as
R3426 T4395 T4392 arg2Of SEM,as
R3427 T4395 T4393 arg1Of SEM,mean
R3428 T4395 T4394 arg1Of SEM,±
R3429 T4397 T4396 arg1Of measurements,The
R3430 T4397 T4398 arg1Of measurements,were
R3431 T4397 T4399 arg2Of measurements,analyzed
R3432 T4399 T4398 arg2Of analyzed,were
R3433 T4402 T4399 arg1Of analysis,analyzed
R3434 T4402 T4400 arg2Of analysis,by
R3435 T4402 T4401 arg1Of analysis,one-way
R3436 T4402 T4403 arg1Of analysis,of
R3437 T4404 T4405 arg1Of variance,(
R3438 T4404 T4408 arg1Of variance,or
R3439 T4406 T4405 arg2Of ANOVA,(
R3440 T4407 T4405 arg3Of ),(
R3441 T4408 T4403 arg2Of or,of
R3442 T4409 T4410 arg2Of Student,'s
R3443 T4411 T4408 arg2Of t-test,or
R3444 T4411 T4410 arg1Of t-test,'s
R3445 T4414 T4415 arg1Of <,.05
R3446 T4416 T4412 arg1Of level,The
R3447 T4416 T4413 arg1Of level,P
R3448 T4416 T4414 arg1Of level,<
R3449 T4416 T4417 arg1Of level,of
R3450 T4416 T4419 arg1Of level,was
R3451 T4416 T4420 arg2Of level,used
R3452 T4418 T4417 arg2Of probability,of
R3453 T4420 T4419 arg2Of used,was
R3454 T4420 T4421 arg1Of used,as
R3455 T4423 T4421 arg2Of criteria,as
R3456 T4423 T4422 arg1Of criteria,the
R3457 T4423 T4424 arg1Of criteria,of
R3458 T4425 T4424 arg2Of significance,of
R3514 T4545 T4544 arg1Of mRNA,TLR4
R3515 T4545 T4546 arg2Of mRNA,Increased
R3516 T4546 T4547 arg1Of Increased,in
R3517 T4549 T4547 arg2Of Tissue,in
R3518 T4549 T4548 arg1Of Tissue,Brain
R3519 T4549 T4550 arg1Of Tissue,after
R3520 T4551 T4550 arg2Of ICH,after
R3521 T4554 T4552 arg1Of levels,TLR4
R3522 T4554 T4553 arg1Of levels,mRNA
R3523 T4554 T4555 arg1Of levels,were
R3524 T4554 T4556 arg2Of levels,detected
R3525 T4556 T4555 arg2Of detected,were
R3526 T4558 T4556 arg1Of Rt-PCR,detected
R3527 T4558 T4557 arg2Of Rt-PCR,by
R3528 T4561 T4559 arg1Of level,The
R3529 T4561 T4560 arg1Of level,low
R3530 T4561 T4562 arg1Of level,of
R3531 T4561 T4565 arg1Of level,was
R3532 T4561 T4566 arg2Of level,observed
R3533 T4564 T4562 arg2Of mRNA,of
R3534 T4564 T4563 arg1Of mRNA,TLR4
R3535 T4566 T4565 arg2Of observed,was
R3536 T4566 T4567 arg1Of observed,in
R3537 T4571 T4567 arg2Of tissue,in
R3538 T4571 T4568 arg1Of tissue,normal
R3539 T4571 T4569 arg1Of tissue,rat
R3540 T4571 T4570 arg1Of tissue,brain
R3541 T4576 T4572 arg2Of group,In
R3542 T4576 T4573 arg1Of group,the
R3543 T4576 T4574 arg1Of group,saline
R3544 T4576 T4575 arg1Of group,control
R3545 T4580 T4578 arg1Of mRNA,the
R3546 T4580 T4579 arg1Of mRNA,TLR4
R3547 T4580 T4582 arg1Of mRNA,increased
R3548 T4580 T4585 arg1Of mRNA,was
R3549 T4580 T4588 arg1Of mRNA,different
R3550 T4582 T4584 arg1Of increased,but
R3551 T4584 T4572 arg1Of but,In
R3552 T4584 T4577 arg1Of but,","
R3553 T4584 T4581 arg1Of but,slightly
R3554 T4584 T4583 arg1Of but,","
R3555 T4585 T4584 arg2Of was,but
R3556 T4585 T4586 arg1Of was,not
R3557 T4588 T4585 arg2Of different,was
R3558 T4588 T4587 arg1Of different,significantly
R3559 T4588 T4589 arg1Of different,from
R3560 T4591 T4589 arg2Of group,from
R3561 T4591 T4590 arg1Of group,normal
R3562 T4596 T4594 arg1Of mRNA,the
R3563 T4596 T4595 arg1Of mRNA,TLR4
R3564 T4596 T4597 arg1Of mRNA,after
R3565 T4596 T4600 arg1Of mRNA,increased
R3566 T4596 T4612 arg1Of mRNA,peaked
R3567 T4596 T4622 arg1Of mRNA,decreased
R3568 T4596 T4637 arg1Of mRNA,maintained
R3569 T4598 T4597 arg2Of ICH,after
R3570 T4600 T4611 arg1Of increased,","
R3571 T4601 T4600 arg2Of starting,increased
R3572 T4601 T4602 arg1Of starting,from
R3573 T4601 T4604 arg1Of starting,after
R3574 T4603 T4602 arg2Of 6 hours,from
R3575 T4605 T4604 arg2Of ICH,after
R3576 T4605 T4606 arg1Of ICH,(
R3577 T4607 T4606 arg2Of P,(
R3578 T4607 T4608 arg1Of P,<
R3579 T4608 T4609 arg1Of <,.05
R3580 T4610 T4606 arg3Of ),(
R3581 T4611 T4620 arg1Of ",",and
R3582 T4612 T4611 arg2Of peaked,","
R3583 T4612 T4613 arg1Of peaked,on
R3584 T4616 T4613 arg2Of day,on
R3585 T4616 T4614 arg1Of day,the
R3586 T4616 T4615 arg1Of day,3rd
R3587 T4616 T4617 arg1Of day,after
R3588 T4618 T4617 arg2Of ICH,after
R3589 T4620 T4592 arg1Of and,However
R3590 T4620 T4593 arg1Of and,","
R3591 T4620 T4599 arg1Of and,significantly
R3592 T4620 T4619 arg1Of and,","
R3593 T4622 T4623 arg1Of decreased,on
R3594 T4622 T4627 arg1Of decreased,after
R3595 T4622 T4635 arg1Of decreased,but
R3596 T4626 T4623 arg2Of day,on
R3597 T4626 T4624 arg1Of day,the
R3598 T4626 T4625 arg1Of day,7th
R3599 T4628 T4627 arg2Of ICH,after
R3600 T4628 T4629 arg1Of ICH,(
R3601 T4630 T4629 arg2Of P,(
R3602 T4630 T4631 arg1Of P,<
R3603 T4631 T4632 arg1Of <,.05
R3604 T4633 T4629 arg3Of ),(
R3605 T4635 T4620 arg2Of but,and
R3606 T4635 T4621 arg1Of but,then
R3607 T4635 T4634 arg1Of but,","
R3608 T4637 T4635 arg2Of maintained,but
R3609 T4637 T4636 arg1Of maintained,still
R3610 T4637 T4641 arg1Of maintained,compared
R3611 T4640 T4637 arg2Of level,maintained
R3612 T4640 T4638 arg1Of level,a
R3613 T4640 T4639 arg1Of level,higher
R3614 T4642 T4641 arg2Of with,compared
R3615 T4644 T4642 arg2Of control,with
R3616 T4644 T4643 arg1Of control,saline
R3617 T4644 T4645 arg1Of control,(
R3618 T4646 T4645 arg2Of P,(
R3619 T4646 T4647 arg1Of P,<
R3620 T4646 T4649 arg1Of P,","
R3621 T4647 T4648 arg1Of <,.05
R3622 T4650 T4649 arg2Of Figure,","
R3623 T4650 T4651 arg1Of Figure,1
R3624 T4652 T4645 arg3Of ),(
R3804 T4959 T4960 arg1Of Expression,of
R3805 T4959 T4963 arg2Of Expression,Increased
R3806 T4962 T4960 arg2Of Protein,of
R3807 T4962 T4961 arg1Of Protein,TLR4
R3808 T4963 T4964 arg1Of Increased,in
R3809 T4966 T4964 arg2Of Tissue,in
R3810 T4966 T4965 arg1Of Tissue,Brain
R3811 T4966 T4967 arg1Of Tissue,after
R3812 T4968 T4967 arg2Of ICH,after
R3813 T4970 T4969 arg1Of investigate,To
R3814 T4973 T4970 arg2Of TLR4,investigate
R3815 T4973 T4971 arg1Of TLR4,the
R3816 T4973 T4972 arg2Of TLR4,increased
R3817 T4973 T4974 arg1Of TLR4,at
R3818 T4977 T4974 arg2Of level,at
R3819 T4977 T4975 arg1Of level,the
R3820 T4977 T4976 arg1Of level,protein
R3821 T4980 T4970 arg1Of expression,investigate
R3822 T4980 T4979 arg1Of expression,the
R3823 T4980 T4981 arg1Of expression,of
R3824 T4980 T4984 arg1Of expression,was
R3825 T4980 T4985 arg2Of expression,measured
R3826 T4983 T4981 arg2Of protein,of
R3827 T4983 T4982 arg1Of protein,TLR4
R3828 T4985 T4969 modOf measured,To
R3829 T4985 T4978 arg1Of measured,","
R3830 T4985 T4984 arg2Of measured,was
R3831 T4985 T4986 arg1Of measured,in
R3832 T4988 T4986 arg2Of tissue,in
R3833 T4988 T4987 arg1Of tissue,brain
R3834 T4991 T4985 arg1Of method,measured
R3835 T4991 T4989 arg2Of method,by
R3836 T4991 T4990 arg1Of method,the
R3837 T4991 T4992 arg1Of method,of
R3838 T4994 T4992 arg2Of Blots,of
R3839 T4994 T4993 arg1Of Blots,Western
R3840 T4994 T4995 arg1Of Blots,using
R3841 T4997 T4995 arg2Of antibodies,using
R3842 T4997 T4996 arg1Of antibodies,specific
R3843 T4997 T4998 arg1Of antibodies,for
R3844 T4999 T4998 arg2Of TLR4,for
R3845 T5001 T5000 arg1Of results,Our
R3846 T5001 T5002 arg1Of results,showed
R3847 T5006 T5004 arg1Of level,a
R3848 T5006 T5005 arg1Of level,low
R3849 T5006 T5007 arg1Of level,of
R3850 T5006 T5010 arg1Of level,was
R3851 T5006 T5011 arg1Of level,detectable
R3852 T5009 T5007 arg2Of protein,of
R3853 T5009 T5008 arg1Of protein,TLR4
R3854 T5010 T5002 arg2Of was,showed
R3855 T5010 T5003 arg1Of was,that
R3856 T5011 T5010 arg2Of detectable,was
R3857 T5011 T5012 arg1Of detectable,in
R3858 T5016 T5012 arg2Of group,in
R3859 T5016 T5013 arg1Of group,the
R3860 T5016 T5014 arg1Of group,saline
R3861 T5016 T5015 arg1Of group,control
R3862 T5018 T5017 arg1Of expression,The
R3863 T5018 T5019 arg1Of expression,of
R3864 T5018 T5022 arg1Of expression,increased
R3865 T5018 T5034 arg1Of expression,peaked
R3866 T5018 T5044 arg1Of expression,decreased
R3867 T5018 T5047 arg2Of expression,maintained
R3868 T5020 T5019 arg2Of TLR4,of
R3869 T5022 T5033 arg1Of increased,","
R3870 T5023 T5022 arg2Of starting,increased
R3871 T5023 T5024 arg1Of starting,from
R3872 T5023 T5026 arg1Of starting,after
R3873 T5025 T5024 arg2Of 6 hours,from
R3874 T5027 T5026 arg2Of ICH,after
R3875 T5027 T5028 arg1Of ICH,(
R3876 T5029 T5028 arg2Of P,(
R3877 T5029 T5030 arg1Of P,<
R3878 T5030 T5031 arg1Of <,.05
R3879 T5032 T5028 arg3Of ),(
R3880 T5033 T5042 arg1Of ",",and
R3881 T5034 T5033 arg2Of peaked,","
R3882 T5034 T5035 arg1Of peaked,on
R3883 T5038 T5035 arg2Of day,on
R3884 T5038 T5036 arg1Of day,the
R3885 T5038 T5037 arg1Of day,3rd
R3886 T5038 T5039 arg1Of day,after
R3887 T5040 T5039 arg2Of ICH,after
R3888 T5042 T5021 arg1Of and,significantly
R3889 T5042 T5041 arg1Of and,","
R3890 T5044 T5045 arg1Of decreased,but
R3891 T5045 T5042 arg2Of but,and
R3892 T5045 T5043 arg1Of but,then
R3893 T5047 T5045 arg2Of maintained,but
R3894 T5047 T5046 arg1Of maintained,still
R3895 T5047 T5048 arg1Of maintained,at
R3896 T5047 T5052 arg1Of maintained,on
R3897 T5047 T5056 arg1Of maintained,after
R3898 T5051 T5048 arg2Of level,at
R3899 T5051 T5049 arg1Of level,a
R3900 T5051 T5050 arg1Of level,high
R3901 T5055 T5052 arg2Of day,on
R3902 T5055 T5053 arg1Of day,the
R3903 T5055 T5054 arg1Of day,7th
R3904 T5057 T5056 arg2Of ICH,after
R3905 T5057 T5058 arg1Of ICH,(
R3906 T5059 T5058 arg2Of P,(
R3907 T5059 T5060 arg1Of P,<
R3908 T5059 T5062 arg1Of P,","
R3909 T5060 T5061 arg1Of <,.05
R3910 T5063 T5062 arg2Of Figure,","
R3911 T5063 T5064 arg1Of Figure,2
R3912 T5065 T5058 arg3Of ),(
R3913 T5067 T5066 arg1Of observation,This
R3914 T5067 T5068 arg1Of observation,of
R3915 T5067 T5071 arg1Of observation,was
R3916 T5067 T5072 arg1Of observation,consistent
R3917 T5070 T5068 arg2Of protein,of
R3918 T5070 T5069 arg1Of protein,TLR4
R3919 T5072 T5071 arg2Of consistent,was
R3920 T5072 T5073 arg1Of consistent,with
R3921 T5076 T5073 arg2Of profile,with
R3922 T5076 T5074 arg1Of profile,the
R3923 T5076 T5075 arg1Of profile,temporal
R3924 T5076 T5077 arg1Of profile,of
R3925 T5076 T5081 arg1Of profile,after
R3926 T5080 T5077 arg2Of mRNA,of
R3927 T5080 T5078 arg1Of mRNA,the
R3928 T5080 T5079 arg1Of mRNA,TLR4
R3929 T5082 T5081 arg2Of ICH,after
R4108 T5392 T5393 arg1Of Distribution,of
R4109 T5392 T5395 arg1Of Distribution,in
R4110 T5392 T5399 arg2Of Distribution,ICH
R4111 T5394 T5393 arg2Of TLR4,of
R4112 T5397 T5395 arg2Of Subjected,in
R4113 T5397 T5396 arg1Of Subjected,Brain
R4114 T5399 T5398 arg1Of ICH,to
R4115 T5401 T5400 arg1Of explore,To
R4116 T5403 T5401 arg2Of distribution,explore
R4117 T5403 T5402 arg1Of distribution,the
R4118 T5403 T5404 arg1Of distribution,of
R4119 T5406 T5404 arg2Of protein,of
R4120 T5406 T5405 arg1Of protein,TLR4
R4121 T5409 T5401 arg1Of TLR4,explore
R4122 T5409 T5408 arg1Of TLR4,the
R4123 T5409 T5410 arg1Of TLR4,was
R4124 T5409 T5411 arg2Of TLR4,detected
R4125 T5411 T5400 modOf detected,To
R4126 T5411 T5407 arg1Of detected,","
R4127 T5411 T5410 arg2Of detected,was
R4128 T5413 T5411 arg1Of immunohistochemistry,detected
R4129 T5413 T5412 arg2Of immunohistochemistry,by
R4130 T5413 T5414 arg1Of immunohistochemistry,(
R4131 T5415 T5414 arg2Of IHC,(
R4132 T5416 T5414 arg3Of ),(
R4133 T5417 T5418 arg1Of Results,showed
R4134 T5421 T5420 arg1Of immunoreactivity,TLR4
R4135 T5421 T5422 arg1Of immunoreactivity,was
R4136 T5421 T5424 arg1Of immunoreactivity,detectable
R4137 T5422 T5418 arg2Of was,showed
R4138 T5422 T5419 arg1Of was,that
R4139 T5422 T5423 arg1Of was,not
R4140 T5424 T5422 arg2Of detectable,was
R4141 T5424 T5425 arg1Of detectable,in
R4142 T5427 T5425 arg2Of tissue,in
R4143 T5427 T5426 arg1Of tissue,brain
R4144 T5427 T5428 arg1Of tissue,from
R4145 T5429 T5430 arg1Of normal,and
R4146 T5431 T5430 arg2Of sham,and
R4147 T5432 T5428 arg2Of control,from
R4148 T5432 T5429 arg1Of control,normal
R4149 T5432 T5431 arg1Of control,sham
R4150 T5435 T5436 arg1Of immunoreactivity,for
R4151 T5435 T5438 arg1Of immunoreactivity,was
R4152 T5435 T5440 arg2Of immunoreactivity,demonstrated
R4153 T5437 T5436 arg2Of TLR4,for
R4154 T5440 T5433 arg1Of demonstrated,However
R4155 T5440 T5434 arg1Of demonstrated,","
R4156 T5440 T5438 arg2Of demonstrated,was
R4157 T5440 T5439 arg1Of demonstrated,consistently
R4158 T5440 T5441 arg1Of demonstrated,in
R4159 T5443 T5442 arg1Of areas,peri-hemorrhage
R4160 T5443 T5444 arg1Of areas,","
R4161 T5443 T5453 arg1Of areas,and
R4162 T5446 T5445 arg1Of hippocampus,the
R4163 T5446 T5447 arg1Of hippocampus,","
R4164 T5446 T5449 arg1Of hippocampus,","
R4165 T5448 T5447 arg2Of cortex,","
R4166 T5449 T5444 arg2Of ",",","
R4167 T5451 T5449 arg2Of nuclei,","
R4168 T5451 T5450 arg1Of nuclei,thalamic
R4169 T5453 T5441 arg2Of and,in
R4170 T5453 T5452 arg1Of and,","
R4171 T5457 T5453 arg2Of tracts,and
R4172 T5457 T5454 arg1Of tracts,some
R4173 T5457 T5455 arg1Of tracts,white
R4174 T5457 T5456 arg1Of tracts,matter
R4175 T5457 T5458 arg1Of tracts,(
R4176 T5459 T5458 arg2Of Figure,(
R4177 T5459 T5460 arg1Of Figure,3
R4178 T5461 T5458 arg3Of ),(
R4281 T5666 T5667 arg1Of Activation,of
R4282 T5670 T5667 arg2Of Signaling,of
R4283 T5670 T5668 arg1Of Signaling,TLR4-Mediated
R4284 T5670 T5669 arg1Of Signaling,NF-Kappa-B
R4285 T5671 T5672 arg1Of Activation,of
R4286 T5671 T5674 arg1Of Activation,induces
R4287 T5673 T5672 arg2Of TLR4,of
R4288 T5676 T5674 arg2Of phosphorylation,induces
R4289 T5676 T5675 arg1Of phosphorylation,the
R4290 T5676 T5677 arg1Of phosphorylation,of
R4291 T5678 T5677 arg2Of inhibitor,of
R4292 T5678 T5679 arg1Of inhibitor,of
R4293 T5680 T5679 arg2Of kappa-B,of
R4294 T5680 T5681 arg1Of kappa-B,(
R4295 T5680 T5684 arg1Of kappa-B,","
R4296 T5680 T5685 arg1Of kappa-B,which
R4297 T5680 T5686 arg1Of kappa-B,dissociates
R4298 T5682 T5681 arg2Of IκB,(
R4299 T5683 T5681 arg3Of ),(
R4300 T5687 T5686 arg2Of IκB,dissociates
R4301 T5687 T5688 arg1Of IκB,with
R4302 T5689 T5688 arg2Of NF-kappa-B,with
R4303 T5689 T5690 arg1Of NF-kappa-B,(
R4304 T5691 T5690 arg2Of NFκB,(
R4305 T5692 T5690 arg3Of ),(
R4306 T5695 T5696 arg1Of NFκB,translocates
R4307 T5695 T5701 arg1Of NFκB,activates
R4308 T5695 T5703 arg1Of NFκB,regulates
R4309 T5696 T5697 arg1Of translocates,into
R4310 T5696 T5700 arg1Of translocates,and
R4311 T5699 T5697 arg2Of nucleus,into
R4312 T5699 T5698 arg1Of nucleus,the
R4313 T5700 T5693 arg1Of and,Then
R4314 T5700 T5694 arg1Of and,","
R4315 T5701 T5702 arg1Of activates,and
R4316 T5702 T5700 arg2Of and,and
R4317 T5703 T5702 arg2Of regulates,and
R4318 T5705 T5701 arg2Of transcription,activates
R4319 T5705 T5703 arg2Of transcription,regulates
R4320 T5705 T5704 arg1Of transcription,the
R4321 T5705 T5706 arg1Of transcription,of
R4322 T5707 T5706 arg2Of genes,of
R4323 T5707 T5708 arg2Of genes,related
R4324 T5708 T5709 arg1Of related,to
R4325 T5711 T5709 arg2Of responses,to
R4326 T5711 T5710 arg1Of responses,inflammatory
R4327 T5713 T5712 arg1Of detectd,To
R4328 T5715 T5713 arg2Of activation,detectd
R4329 T5715 T5714 arg1Of activation,the
R4330 T5715 T5716 arg1Of activation,of
R4331 T5719 T5716 arg2Of signaling,of
R4332 T5719 T5717 arg1Of signaling,TLR4-mediated
R4333 T5719 T5718 arg1Of signaling,NFκB
R4334 T5722 T5721 arg1Of phosphorylation,the
R4335 T5722 T5723 arg1Of phosphorylation,of
R4336 T5722 T5734 arg1Of phosphorylation,were
R4337 T5722 T5735 arg2Of phosphorylation,measured
R4338 T5724 T5723 arg2Of inhibitor,of
R4339 T5724 T5725 arg1Of inhibitor,of
R4340 T5726 T5727 arg1Of kappa-B,(
R4341 T5726 T5730 arg1Of kappa-B,and
R4342 T5728 T5727 arg2Of p-IκB,(
R4343 T5729 T5727 arg3Of ),(
R4344 T5730 T5725 arg2Of and,of
R4345 T5731 T5730 arg2Of activity,and
R4346 T5731 T5732 arg1Of activity,of
R4347 T5733 T5732 arg2Of NFκB,of
R4348 T5735 T5712 modOf measured,To
R4349 T5735 T5720 arg1Of measured,","
R4350 T5735 T5734 arg2Of measured,were
R4351 T5737 T5735 arg1Of methods,measured
R4352 T5737 T5736 arg2Of methods,by
R4353 T5737 T5738 arg1Of methods,of
R4354 T5740 T5739 arg1Of Blots,Western
R4355 T5740 T5741 arg1Of Blots,and
R4356 T5741 T5738 arg2Of and,of
R4357 T5742 T5741 arg2Of EMSA,and
R4358 T5743 T5744 arg1Of Results,showed
R4359 T5747 T5746 arg1Of p-IκB,the
R4360 T5747 T5748 arg1Of p-IκB,increased
R4361 T5748 T5744 arg2Of increased,showed
R4362 T5748 T5745 arg1Of increased,that
R4363 T5748 T5749 arg1Of increased,at
R4364 T5748 T5751 arg1Of increased,after
R4365 T5750 T5749 arg2Of 6 hours,at
R4366 T5752 T5753 arg1Of ICH,(
R4367 T5752 T5759 arg1Of ICH,peaked
R4368 T5752 T5767 arg1Of ICH,maintained
R4369 T5754 T5753 arg2Of P,(
R4370 T5754 T5755 arg1Of P,<
R4371 T5755 T5756 arg1Of <,.05
R4372 T5757 T5753 arg3Of ),(
R4373 T5759 T5760 arg1Of peaked,on
R4374 T5759 T5763 arg1Of peaked,after
R4375 T5759 T5766 arg1Of peaked,and
R4376 T5762 T5760 arg2Of days,on
R4377 T5762 T5761 arg1Of days,3
R4378 T5764 T5763 arg2Of ICH,after
R4379 T5766 T5751 arg2Of and,after
R4380 T5766 T5758 arg1Of and,","
R4381 T5766 T5765 arg1Of and,","
R4382 T5767 T5766 arg2Of maintained,and
R4383 T5767 T5771 arg1Of maintained,on
R4384 T5770 T5767 arg2Of level,maintained
R4385 T5770 T5768 arg1Of level,a
R4386 T5770 T5769 arg1Of level,high
R4387 T5773 T5771 arg2Of days,on
R4388 T5773 T5772 arg1Of days,7
R4389 T5773 T5774 arg1Of days,after
R4390 T5773 T5776 arg1Of days,(
R4391 T5775 T5774 arg2Of ICH,after
R4392 T5777 T5776 arg2Of P,(
R4393 T5777 T5778 arg1Of P,<
R4394 T5777 T5780 arg1Of P,","
R4395 T5778 T5779 arg1Of <,.05
R4396 T5781 T5780 arg2Of Figure,","
R4397 T5781 T5782 arg1Of Figure,5
R4398 T5783 T5776 arg3Of ),(
R4399 T5785 T5784 arg2Of expected,As
R4400 T5788 T5787 arg1Of activity,the
R4401 T5788 T5789 arg1Of activity,of
R4402 T5788 T5791 arg1Of activity,was
R4403 T5788 T5793 arg2Of activity,increased
R4404 T5790 T5789 arg2Of NFκB,of
R4405 T5793 T5784 arg1Of increased,As
R4406 T5793 T5786 arg1Of increased,","
R4407 T5793 T5791 arg2Of increased,was
R4408 T5793 T5792 arg1Of increased,also
R4409 T5793 T5794 arg1Of increased,in
R4410 T5793 T5798 arg1Of increased,as
R4411 T5797 T5794 arg2Of manner,in
R4412 T5797 T5795 arg1Of manner,the
R4413 T5797 T5796 arg1Of manner,same
R4414 T5799 T5798 arg2Of that,as
R4415 T5799 T5800 arg1Of that,of
R4416 T5802 T5800 arg2Of p-IκB,of
R4417 T5802 T5801 arg1Of p-IκB,the
R4418 T5802 T5803 arg1Of p-IκB,(
R4419 T5804 T5803 arg2Of Figure,(
R4420 T5804 T5805 arg1Of Figure,4
R4421 T5806 T5803 arg3Of ),(
R4719 T6548 T6547 arg1Of hemorrhage,Intra-cerebral
R4720 T6548 T6549 arg1Of hemorrhage,(
R4721 T6548 T6552 arg1Of hemorrhage,represents
R4722 T6548 T6560 arg1Of hemorrhage,occurs
R4723 T6550 T6549 arg2Of ICH,(
R4724 T6551 T6549 arg3Of ),(
R4725 T6552 T6559 arg1Of represents,and
R4726 T6554 T6552 arg2Of %,represents
R4727 T6554 T6553 arg1Of %,10–15
R4728 T6554 T6555 arg1Of %,of
R4729 T6557 T6555 arg2Of strokes,of
R4730 T6557 T6556 arg1Of strokes,all
R4731 T6559 T6558 arg1Of and,","
R4732 T6560 T6559 arg2Of occurs,and
R4733 T6560 T6561 arg1Of occurs,with
R4734 T6560 T6564 arg1Of occurs,as
R4735 T6563 T6561 arg2Of frequency,with
R4736 T6563 T6562 arg1Of frequency,increasing
R4737 T6566 T6564 arg2Of complication,as
R4738 T6566 T6565 arg1Of complication,a
R4739 T6566 T6567 arg1Of complication,of
R4740 T6570 T6567 arg2Of treatment,of
R4741 T6570 T6568 arg1Of treatment,the
R4742 T6570 T6569 arg1Of treatment,thrombolytic
R4743 T6570 T6571 arg1Of treatment,of
R4744 T6570 T6574 arg1Of treatment,[
R4745 T6573 T6571 arg2Of stroke,of
R4746 T6573 T6572 arg1Of stroke,ischemic
R4747 T6575 T6574 arg2Of 1,[
R4748 T6576 T6574 arg3Of ],[
R4749 T6578 T6577 arg1Of mortality,The
R4750 T6578 T6579 arg1Of mortality,of
R4751 T6578 T6581 arg1Of mortality,is
R4752 T6578 T6582 arg1Of mortality,higher
R4753 T6580 T6579 arg2Of ICH,of
R4754 T6582 T6581 arg2Of higher,is
R4755 T6582 T6583 arg1Of higher,than
R4756 T6584 T6583 arg2Of that,than
R4757 T6584 T6585 arg1Of that,of
R4758 T6587 T6585 arg2Of stroke,of
R4759 T6587 T6586 arg1Of stroke,ischemic
R4760 T6589 T6588 arg1Of 31,Only
R4761 T6590 T6589 arg1Of %,31
R4762 T6590 T6591 arg1Of %,are
R4763 T6590 T6593 arg1Of %,independent
R4764 T6591 T6592 arg1Of are,functionally
R4765 T6591 T6594 arg1Of are,at
R4766 T6593 T6591 arg2Of independent,are
R4767 T6596 T6594 arg2Of months,at
R4768 T6596 T6595 arg1Of months,3
R4769 T6598 T6597 arg1Of 38,Only
R4770 T6599 T6598 arg1Of %,38
R4771 T6599 T6600 arg1Of %,of
R4772 T6599 T6603 arg1Of %,survive
R4773 T6602 T6600 arg2Of patients,of
R4774 T6602 T6601 arg1Of patients,the
R4775 T6603 T6607 arg1Of survive,[
R4776 T6606 T6603 arg2Of year,survive
R4777 T6606 T6604 arg1Of year,the
R4778 T6606 T6605 arg1Of year,1st
R4779 T6608 T6607 arg2Of 10,[
R4780 T6609 T6607 arg3Of ],[
R4781 T6613 T6612 arg1Of method,the
R4782 T6613 T6614 arg1Of method,for
R4783 T6613 T6627 arg1Of method,are
R4784 T6613 T6629 arg1Of method,effective
R4785 T6615 T6616 arg1Of treatment,of
R4786 T6615 T6619 arg1Of treatment,and
R4787 T6618 T6616 arg2Of disease,of
R4788 T6618 T6617 arg1Of disease,this
R4789 T6619 T6614 arg2Of and,for
R4790 T6619 T6625 arg1Of and,after
R4791 T6620 T6619 arg2Of protection,and
R4792 T6620 T6621 arg1Of protection,of
R4793 T6624 T6621 arg2Of tissue,of
R4794 T6624 T6622 arg1Of tissue,the
R4795 T6624 T6623 arg1Of tissue,brain
R4796 T6626 T6625 arg2Of ICH,after
R4797 T6627 T6610 arg1Of are,Unfortunately
R4798 T6627 T6611 arg1Of are,","
R4799 T6627 T6628 arg1Of are,not
R4800 T6629 T6627 arg2Of effective,are
R4801 T6631 T6630 arg1Of effect,Mass
R4802 T6631 T6632 arg1Of effect,","
R4803 T6632 T6635 arg1Of ",",and
R4804 T6633 T6632 arg2Of ischemia,","
R4805 T6635 T6634 arg1Of and,","
R4806 T6635 T6637 arg1Of and,of
R4807 T6635 T6640 arg1Of and,after
R4808 T6635 T6642 arg1Of and,induce
R4809 T6636 T6635 arg2Of toxicity,and
R4810 T6639 T6637 arg2Of components,of
R4811 T6639 T6638 arg1Of components,blood
R4812 T6641 T6640 arg2Of ICH,after
R4813 T6645 T6642 arg2Of damage,induce
R4814 T6645 T6643 arg1Of damage,brain
R4815 T6645 T6644 arg1Of damage,tissue
R4816 T6647 T6646 arg2Of addition,In
R4817 T6649 T6650 arg1Of there,is
R4818 T6650 T6646 arg1Of is,In
R4819 T6650 T6648 arg1Of is,","
R4820 T6652 T6650 arg2Of evidence,is
R4821 T6652 T6651 arg1Of evidence,increasing
R4822 T6655 T6654 arg1Of processes,inflammatory
R4823 T6655 T6656 arg1Of processes,are
R4824 T6655 T6657 arg2Of processes,involved
R4825 T6657 T6652 arg2Of involved,evidence
R4826 T6657 T6653 arg1Of involved,that
R4827 T6657 T6656 arg2Of involved,are
R4828 T6657 T6658 arg1Of involved,in
R4829 T6660 T6658 arg2Of events,in
R4830 T6660 T6659 arg1Of events,cerebrovascular
R4831 T6662 T6661 arg2Of ICH,After
R4832 T6665 T6664 arg1Of mediators,inflammatory
R4833 T6665 T6666 arg1Of mediators,from
R4834 T6665 T6669 arg1Of mediators,might
R4835 T6665 T6670 arg1Of mediators,enter
R4836 T6665 T6675 arg1Of mediators,induce
R4837 T6668 T6666 arg2Of blood,from
R4838 T6668 T6667 arg1Of blood,the
R4839 T6670 T6671 arg1Of enter,to
R4840 T6670 T6674 arg1Of enter,and
R4841 T6673 T6671 arg2Of brain,to
R4842 T6673 T6672 arg1Of brain,the
R4843 T6674 T6669 arg2Of and,might
R4844 T6674 T6679 arg1Of and,and
R4845 T6675 T6674 arg2Of induce,and
R4846 T6678 T6675 arg2Of reaction,induce
R4847 T6678 T6676 arg1Of reaction,an
R4848 T6678 T6677 arg1Of reaction,inflammatory
R4849 T6679 T6661 arg1Of and,After
R4850 T6679 T6663 arg1Of and,","
R4851 T6682 T6680 arg1Of cells,the
R4852 T6682 T6681 arg1Of cells,brain
R4853 T6682 T6683 arg1Of cells,itself
R4854 T6682 T6684 arg1Of cells,are
R4855 T6682 T6686 arg1Of cells,capable
R4856 T6682 T6688 arg1Of cells,producing
R4857 T6684 T6679 arg2Of are,and
R4858 T6684 T6685 arg1Of are,also
R4859 T6686 T6684 arg2Of capable,are
R4860 T6686 T6687 arg1Of capable,of
R4861 T6688 T6687 arg2Of producing,of
R4862 T6688 T6693 arg1Of producing,[
R4863 T6689 T6688 arg2Of many,producing
R4864 T6689 T6690 arg1Of many,of
R4865 T6692 T6690 arg2Of agents,of
R4866 T6692 T6691 arg1Of agents,these
R4867 T6694 T6693 arg2Of 11,[
R4868 T6695 T6693 arg3Of ],[
R4869 T6698 T6696 arg1Of responses,The
R4870 T6698 T6697 arg1Of responses,inflammatory
R4871 T6698 T6699 arg1Of responses,are
R4872 T6698 T6700 arg1Of responses,responsible
R4873 T6700 T6699 arg2Of responsible,are
R4874 T6700 T6701 arg1Of responsible,for
R4875 T6704 T6703 arg1Of induced,ICH
R4876 T6706 T6701 arg2Of injury,for
R4877 T6706 T6702 arg1Of injury,the
R4878 T6706 T6704 arg1Of injury,induced
R4879 T6706 T6705 arg1Of injury,brain
R4880 T6706 T6707 arg1Of injury,","
R4881 T6706 T6708 arg1Of injury,which
R4882 T6706 T6709 arg1Of injury,could
R4883 T6706 T6710 arg1Of injury,provide
R4884 T6710 T6709 arg2Of provide,could
R4885 T6712 T6711 arg1Of therapeutic,new
R4886 T6713 T6710 arg2Of targets,provide
R4887 T6713 T6712 arg1Of targets,therapeutic
R4888 T6713 T6714 arg1Of targets,for
R4889 T6715 T6714 arg2Of ICH,for
R4890 T6717 T6716 arg1Of constituents,Various
R4891 T6717 T6718 arg1Of constituents,of
R4892 T6717 T6722 arg1Of constituents,","
R4893 T6717 T6723 arg1Of constituents,including
R4894 T6717 T6733 arg1Of constituents,and
R4895 T6721 T6718 arg2Of response,of
R4896 T6721 T6719 arg1Of response,the
R4897 T6721 T6720 arg1Of response,inflammatory
R4898 T6725 T6724 arg1Of molecules,adhesion
R4899 T6725 T6726 arg1Of molecules,","
R4900 T6726 T6728 arg1Of ",",","
R4901 T6727 T6726 arg2Of cytokines,","
R4902 T6728 T6730 arg1Of ",",","
R4903 T6729 T6728 arg2Of leukocytes,","
R4904 T6730 T6723 arg2Of ",",including
R4905 T6731 T6730 arg2Of immunoglobulins,","
R4906 T6733 T6732 arg1Of and,","
R4907 T6733 T6736 arg1Of and,may
R4908 T6733 T6737 arg1Of and,be
R4909 T6733 T6738 arg1Of and,important
R4910 T6734 T6733 arg2Of complement,and
R4911 T6737 T6735 arg1Of be,","
R4912 T6737 T6736 arg2Of be,may
R4913 T6737 T6739 arg1Of be,in
R4914 T6738 T6737 arg2Of important,be
R4915 T6741 T6739 arg2Of pathogenesis,in
R4916 T6741 T6740 arg1Of pathogenesis,the
R4917 T6741 T6742 arg1Of pathogenesis,of
R4918 T6743 T6742 arg2Of ICH,of
R4919 T6746 T6760 arg1Of how,is
R4920 T6746 T6761 arg1Of how,unclear
R4921 T6749 T6747 arg1Of responses,the
R4922 T6749 T6748 arg1Of responses,inflammatory
R4923 T6749 T6750 arg1Of responses,is
R4924 T6749 T6751 arg2Of responses,activated
R4925 T6749 T6753 arg2Of responses,regulated
R4926 T6751 T6752 arg1Of activated,and
R4927 T6752 T6746 arg1Of and,how
R4928 T6752 T6750 arg2Of and,is
R4929 T6752 T6754 arg1Of and,in
R4930 T6753 T6752 arg2Of regulated,and
R4931 T6757 T6754 arg2Of tissue,in
R4932 T6757 T6755 arg1Of tissue,the
R4933 T6757 T6756 arg1Of tissue,brain
R4934 T6757 T6758 arg1Of tissue,after
R4935 T6759 T6758 arg2Of ICH,after
R4936 T6760 T6744 arg1Of is,However
R4937 T6760 T6745 arg1Of is,","
R4938 T6761 T6760 arg2Of unclear,is
R4939 T6765 T6762 arg1Of factor-kappa-B,Transcription
R4940 T6765 T6763 arg1Of factor-kappa-B,factor
R4941 T6765 T6764 arg1Of factor-kappa-B,nuclear
R4942 T6765 T6766 arg1Of factor-kappa-B,(
R4943 T6765 T6769 arg1Of factor-kappa-B,is
R4944 T6767 T6766 arg2Of NFκB,(
R4945 T6768 T6766 arg3Of ),(
R4946 T6774 T6769 arg2Of factor,is
R4947 T6774 T6770 arg1Of factor,an
R4948 T6774 T6771 arg1Of factor,important
R4949 T6774 T6772 arg1Of factor,nuclear
R4950 T6774 T6773 arg1Of factor,transcription
R4951 T6774 T6775 arg1Of factor,","
R4952 T6774 T6776 arg1Of factor,which
R4953 T6774 T6777 arg1Of factor,initiates
R4954 T6774 T6794 arg1Of factor,plays
R4955 T6774 T6799 arg1Of factor,regulating
R4956 T6777 T6792 arg1Of initiates,and
R4957 T6778 T6777 arg2Of transcription,initiates
R4958 T6778 T6779 arg1Of transcription,of
R4959 T6780 T6779 arg2Of genes,of
R4960 T6780 T6781 arg2Of genes,associated
R4961 T6781 T6782 arg1Of associated,with
R4962 T6781 T6787 arg1Of associated,[
R4963 T6784 T6783 arg1Of responses,immune
R4964 T6784 T6785 arg1Of responses,and
R4965 T6785 T6782 arg2Of and,with
R4966 T6786 T6785 arg2Of inflammation,and
R4967 T6788 T6789 arg1Of 12,","
R4968 T6789 T6787 arg2Of ",",[
R4969 T6790 T6789 arg2Of 13,","
R4970 T6791 T6787 arg3Of ],[
R4971 T6794 T6792 arg2Of plays,and
R4972 T6794 T6793 arg1Of plays,also
R4973 T6794 T6798 arg1Of plays,in
R4974 T6797 T6794 arg2Of role,plays
R4975 T6797 T6795 arg1Of role,a
R4976 T6797 T6796 arg1Of role,key
R4977 T6799 T6798 arg2Of regulating,in
R4978 T6799 T6801 arg1Of regulating,in
R4979 T6800 T6799 arg2Of inflammation,regulating
R4980 T6803 T6801 arg2Of pathologies,in
R4981 T6803 T6802 arg1Of pathologies,brain
R4982 T6804 T6805 arg1Of It,has
R4983 T6804 T6806 arg1Of It,been
R4984 T6804 T6807 arg2Of It,reported
R4985 T6807 T6805 arg2Of reported,has
R4986 T6807 T6806 arg2Of reported,been
R4987 T6809 T6810 arg1Of NFκB,increased
R4988 T6810 T6807 arg3Of increased,reported
R4989 T6810 T6808 arg1Of increased,that
R4990 T6810 T6811 arg1Of increased,in
R4991 T6813 T6811 arg2Of region,in
R4992 T6813 T6812 arg1Of region,the
R4993 T6813 T6814 arg1Of region,of
R4994 T6813 T6816 arg1Of region,after
R4995 T6815 T6814 arg2Of perihematoma,of
R4996 T6817 T6816 arg2Of ICH,after
R4997 T6817 T6818 arg1Of ICH,[
R4998 T6819 T6818 arg2Of 14,[
R4999 T6820 T6818 arg3Of ],[
R5000 T6822 T6821 arg1Of activation,NFκB
R5001 T6822 T6823 arg1Of activation,occurs
R5002 T6822 T6827 arg1Of activation,persists
R5003 T6823 T6824 arg1Of occurs,within
R5004 T6823 T6826 arg1Of occurs,and
R5005 T6825 T6824 arg2Of minutes,within
R5006 T6827 T6826 arg2Of persists,and
R5007 T6827 T6828 arg1Of persists,for
R5008 T6830 T6829 arg1Of least,at
R5009 T6832 T6828 arg2Of week,for
R5010 T6832 T6830 arg1Of week,least
R5011 T6832 T6831 arg1Of week,a
R5012 T6832 T6833 arg1Of week,in
R5013 T6832 T6837 arg1Of week,","
R5014 T6832 T6838 arg1Of week,which
R5015 T6832 T6839 arg1Of week,is
R5016 T6832 T6840 arg2Of week,associated
R5017 T6833 T6835 arg1Of in,to
R5018 T6834 T6833 arg2Of response,in
R5019 T6836 T6833 arg3Of ICH,in
R5020 T6840 T6839 arg2Of associated,is
R5021 T6840 T6841 arg1Of associated,with
R5022 T6843 T6841 arg2Of expression,with
R5023 T6843 T6842 arg1Of expression,the
R5024 T6843 T6844 arg1Of expression,of
R5025 T6847 T6844 arg2Of genes,of
R5026 T6847 T6845 arg2Of genes,selected
R5027 T6847 T6846 arg1Of genes,target
R5028 T6847 T6848 arg1Of genes,[
R5029 T6849 T6848 arg2Of 15,[
R5030 T6850 T6848 arg3Of ],[
R5031 T6851 T6852 arg1Of Activation,of
R5032 T6851 T6854 arg1Of Activation,initiates
R5033 T6851 T6858 arg1Of Activation,contributes
R5034 T6853 T6852 arg2Of NFκB,of
R5035 T6854 T6857 arg1Of initiates,and
R5036 T6856 T6854 arg2Of responses,initiates
R5037 T6856 T6855 arg1Of responses,inflammatory
R5038 T6857 T6868 arg1Of and,[
R5039 T6858 T6857 arg2Of contributes,and
R5040 T6858 T6859 arg1Of contributes,to
R5041 T6858 T6866 arg1Of contributes,after
R5042 T6861 T6859 arg2Of pathobiology,to
R5043 T6861 T6860 arg1Of pathobiology,the
R5044 T6861 T6862 arg1Of pathobiology,of
R5045 T6865 T6862 arg2Of death,of
R5046 T6865 T6863 arg1Of death,perilesional
R5047 T6865 T6864 arg1Of death,cell
R5048 T6867 T6866 arg2Of ICH,after
R5049 T6869 T6868 arg2Of 16,[
R5050 T6870 T6868 arg3Of ],[
R5051 T6871 T6872 arg1Of Inhibition,of
R5052 T6871 T6875 arg1Of Inhibition,has
R5053 T6871 T6876 arg1Of Inhibition,been
R5054 T6871 T6877 arg2Of Inhibition,shown
R5055 T6871 T6879 arg1Of Inhibition,have
R5056 T6874 T6872 arg2Of activity,of
R5057 T6874 T6873 arg1Of activity,NFκB
R5058 T6877 T6875 arg2Of shown,has
R5059 T6877 T6876 arg2Of shown,been
R5060 T6879 T6877 arg3Of have,shown
R5061 T6879 T6878 arg1Of have,to
R5062 T6882 T6879 arg2Of effect,have
R5063 T6882 T6880 arg1Of effect,a
R5064 T6882 T6881 arg1Of effect,therapeutic
R5065 T6882 T6883 arg1Of effect,on
R5066 T6882 T6886 arg1Of effect,","
R5067 T6882 T6888 arg1Of effect,as
R5068 T6885 T6883 arg2Of ICH,on
R5069 T6885 T6884 arg1Of ICH,experimental
R5070 T6888 T6887 arg1Of as,such
R5071 T6890 T6889 arg1Of inflammation,reduce
R5072 T6890 T6891 arg1Of inflammation,","
R5073 T6891 T6895 arg1Of ",",and
R5074 T6893 T6891 arg2Of dysfunction,","
R5075 T6893 T6892 arg1Of dysfunction,behavioral
R5076 T6895 T6888 arg2Of and,as
R5077 T6895 T6894 arg1Of and,","
R5078 T6897 T6895 arg2Of damage,and
R5079 T6897 T6896 arg1Of damage,neuronal
R5080 T6897 T6898 arg2Of damage,produced
R5081 T6898 T6901 arg1Of produced,[
R5082 T6900 T6898 arg1Of ICH,produced
R5083 T6900 T6899 arg2Of ICH,by
R5084 T6902 T6901 arg2Of 17,[
R5085 T6903 T6901 arg3Of ],[
R5086 T6905 T6904 arg1Of knowledge,The
R5087 T6905 T6906 arg1Of knowledge,about
R5088 T6905 T6917 arg1Of knowledge,is
R5089 T6905 T6918 arg1Of knowledge,critical
R5090 T6907 T6906 arg2Of how,about
R5091 T6908 T6909 arg1Of NFκB,is
R5092 T6908 T6910 arg2Of NFκB,activated
R5093 T6910 T6907 arg1Of activated,how
R5094 T6910 T6909 arg2Of activated,is
R5095 T6910 T6911 arg1Of activated,in
R5096 T6913 T6911 arg2Of brain,in
R5097 T6913 T6912 arg1Of brain,the
R5098 T6913 T6914 arg2Of brain,subjected
R5099 T6914 T6915 arg1Of subjected,to
R5100 T6916 T6915 arg2Of ICH,to
R5101 T6918 T6917 arg2Of critical,is
R5102 T6918 T6919 arg1Of critical,for
R5103 T6920 T6919 arg2Of seeking,for
R5104 T6924 T6920 arg2Of method,seeking
R5105 T6924 T6921 arg1Of method,a
R5106 T6924 T6922 arg1Of method,new
R5107 T6924 T6923 arg1Of method,neuroprotective
R5108 T6924 T6925 arg1Of method,for
R5109 T6926 T6925 arg2Of ICH,for
R5110 T6928 T6927 arg1Of receptors,Toll-like
R5111 T6928 T6929 arg1Of receptors,(
R5112 T6928 T6932 arg1Of receptors,are
R5113 T6928 T6940 arg1Of receptors,play
R5114 T6930 T6929 arg2Of TLRs,(
R5115 T6931 T6929 arg3Of ),(
R5116 T6932 T6939 arg1Of are,and
R5117 T6934 T6932 arg2Of family,are
R5118 T6934 T6933 arg1Of family,a
R5119 T6934 T6935 arg1Of family,of
R5120 T6938 T6935 arg2Of molecules,of
R5121 T6938 T6936 arg1Of molecules,signal
R5122 T6938 T6937 arg1Of molecules,transduction
R5123 T6940 T6939 arg2Of play,and
R5124 T6940 T6944 arg1Of play,in
R5125 T6943 T6940 arg2Of role,play
R5126 T6943 T6941 arg1Of role,a
R5127 T6943 T6942 arg1Of role,critical
R5128 T6946 T6944 arg2Of induction,in
R5129 T6946 T6945 arg1Of induction,the
R5130 T6946 T6947 arg1Of induction,of
R5131 T6948 T6949 arg1Of innate,and
R5132 T6950 T6949 arg2Of adaptive,and
R5133 T6951 T6947 arg2Of immunity,of
R5134 T6951 T6948 arg1Of immunity,innate
R5135 T6951 T6950 arg1Of immunity,adaptive
R5136 T6951 T6952 arg1Of immunity,[
R5137 T6953 T6952 arg2Of 4,[
R5138 T6954 T6952 arg3Of ],[
R5139 T6957 T6955 arg1Of pathways,TLR-mediated
R5140 T6957 T6956 arg1Of pathways,signaling
R5141 T6957 T6959 arg1Of pathways,stimulate
R5142 T6959 T6958 arg1Of stimulate,mainly
R5143 T6959 T6964 arg1Of stimulate,[
R5144 T6961 T6959 arg2Of activation,stimulate
R5145 T6961 T6960 arg1Of activation,the
R5146 T6961 T6962 arg1Of activation,of
R5147 T6963 T6962 arg2Of NFκB,of
R5148 T6965 T6964 arg2Of 12,[
R5149 T6965 T6966 arg1Of 12,","
R5150 T6967 T6966 arg2Of 13,","
R5151 T6968 T6964 arg3Of ],[
R5152 T6969 T6970 arg1Of TLR4,","
R5153 T6969 T6977 arg1Of TLR4,has
R5154 T6969 T6978 arg1Of TLR4,been
R5155 T6969 T6979 arg2Of TLR4,reported
R5156 T6969 T6981 arg1Of TLR4,be
R5157 T6969 T6982 arg2Of TLR4,involved
R5158 T6974 T6970 arg2Of TLR,","
R5159 T6974 T6971 arg1Of TLR,the
R5160 T6974 T6972 arg1Of TLR,first
R5161 T6974 T6973 arg1Of TLR,mammalian
R5162 T6974 T6975 arg2Of TLR,recognized
R5163 T6979 T6976 arg1Of reported,","
R5164 T6979 T6977 arg2Of reported,has
R5165 T6979 T6978 arg2Of reported,been
R5166 T6982 T6979 arg3Of involved,reported
R5167 T6982 T6980 arg1Of involved,to
R5168 T6982 T6981 arg2Of involved,be
R5169 T6982 T6983 arg1Of involved,in
R5170 T6986 T6985 arg1Of nervous,central
R5171 T6986 T6987 arg1Of nervous,(
R5172 T6988 T6987 arg2Of CNS,(
R5173 T6989 T6987 arg3Of ),(
R5174 T6991 T6983 arg2Of diseases,in
R5175 T6991 T6984 arg1Of diseases,several
R5176 T6991 T6986 arg1Of diseases,nervous
R5177 T6991 T6990 arg1Of diseases,system
R5178 T6991 T6992 arg1Of diseases,","
R5179 T6991 T6994 arg1Of diseases,as
R5180 T6994 T6993 arg1Of as,such
R5181 T6995 T6996 arg1Of inflammatory,or
R5182 T6997 T6996 arg2Of autoimmune,or
R5183 T6999 T6995 arg1Of diseases,inflammatory
R5184 T6999 T6997 arg1Of diseases,autoimmune
R5185 T6999 T6998 arg1Of diseases,CNS
R5186 T6999 T7000 arg1Of diseases,and
R5187 T7000 T6994 arg2Of and,as
R5188 T7003 T7000 arg2Of injury,and
R5189 T7003 T7001 arg1Of injury,cerebral
R5190 T7003 T7002 arg1Of injury,ischemic
R5191 T7003 T7004 arg1Of injury,[
R5192 T7005 T7004 arg2Of 7,[
R5193 T7005 T7006 arg1Of 7,","
R5194 T7007 T7006 arg2Of 8,","
R5195 T7008 T7004 arg3Of ],[
R5196 T7011 T7010 arg1Of reports,previous
R5197 T7011 T7012 arg1Of reports,indicated
R5198 T7012 T7009 arg2Of indicated,Although
R5199 T7015 T7014 arg1Of activation,the
R5200 T7015 T7016 arg1Of activation,of
R5201 T7015 T7018 arg1Of activation,was
R5202 T7015 T7019 arg2Of activation,attributed
R5203 T7017 T7016 arg2Of NFκB,of
R5204 T7019 T7012 arg2Of attributed,indicated
R5205 T7019 T7013 arg1Of attributed,that
R5206 T7019 T7018 arg2Of attributed,was
R5207 T7019 T7020 arg1Of attributed,to
R5208 T7023 T7024 arg1Of stress,or
R5209 T7025 T7024 arg2Of glutamate,or
R5210 T7027 T7020 arg2Of activation,to
R5211 T7027 T7021 arg1Of activation,the
R5212 T7027 T7022 arg1Of activation,oxidative
R5213 T7027 T7023 arg1Of activation,stress
R5214 T7027 T7025 arg1Of activation,glutamate
R5215 T7027 T7026 arg1Of activation,receptor
R5216 T7027 T7028 arg2Of activation,induced
R5217 T7032 T7030 arg1Of cells,red
R5218 T7032 T7031 arg1Of cells,blood
R5219 T7032 T7033 arg1Of cells,and/or
R5220 T7033 T7028 arg1Of and/or,induced
R5221 T7033 T7029 arg2Of and/or,by
R5222 T7035 T7033 arg2Of constituents,and/or
R5223 T7035 T7034 arg1Of constituents,plasma
R5224 T7035 T7036 arg1Of constituents,[
R5225 T7037 T7036 arg2Of 17,[
R5226 T7038 T7036 arg3Of ],[
R5227 T7041 T7040 arg1Of few,very
R5228 T7042 T7041 arg1Of studies,few
R5229 T7042 T7043 arg1Of studies,have
R5230 T7042 T7044 arg1Of studies,been
R5231 T7042 T7045 arg2Of studies,directed
R5232 T7042 T7047 arg1Of studies,investigate
R5233 T7045 T7009 arg1Of directed,Although
R5234 T7045 T7039 arg1Of directed,","
R5235 T7045 T7043 arg2Of directed,have
R5236 T7045 T7044 arg2Of directed,been
R5237 T7047 T7045 arg3Of investigate,directed
R5238 T7047 T7046 arg1Of investigate,to
R5239 T7049 T7048 arg1Of role,the
R5240 T7049 T7050 arg1Of role,and
R5241 T7050 T7047 arg2Of and,investigate
R5242 T7052 T7050 arg2Of relationship,and
R5243 T7052 T7051 arg1Of relationship,the
R5244 T7052 T7053 arg1Of relationship,between
R5245 T7056 T7057 arg1Of signaling,and
R5246 T7057 T7053 arg2Of and,between
R5247 T7057 T7054 arg1Of and,TLR4-mediated
R5248 T7057 T7055 arg1Of and,NFκB
R5249 T7058 T7057 arg2Of ICH,and
R5250 T7062 T7059 arg2Of study,In
R5251 T7062 T7060 arg1Of study,the
R5252 T7062 T7061 arg1Of study,present
R5253 T7064 T7065 arg1Of we,established
R5254 T7064 T7073 arg1Of we,detected
R5255 T7065 T7072 arg1Of established,and
R5256 T7068 T7065 arg2Of model,established
R5257 T7068 T7066 arg1Of model,the
R5258 T7068 T7067 arg1Of model,rat
R5259 T7068 T7069 arg1Of model,of
R5260 T7071 T7069 arg2Of ICH,of
R5261 T7071 T7070 arg1Of ICH,experimental
R5262 T7072 T7059 arg1Of and,In
R5263 T7072 T7063 arg1Of and,","
R5264 T7073 T7072 arg2Of detected,and
R5265 T7076 T7077 arg1Of mRNA,and
R5266 T7077 T7073 arg2Of and,detected
R5267 T7077 T7074 arg1Of and,the
R5268 T7077 T7075 arg1Of and,TLR4
R5269 T7078 T7077 arg2Of protein,and
R5270 T7080 T7079 arg1Of data,Our
R5271 T7080 T7081 arg1Of data,showed
R5272 T7083 T7084 arg1Of transcription,of
R5273 T7083 T7088 arg1Of transcription,as
R5274 T7085 T7084 arg2Of TLR4,of
R5275 T7088 T7086 arg1Of as,as
R5276 T7088 T7087 arg1Of as,well
R5277 T7088 T7097 arg2Of as,elevated
R5278 T7090 T7088 arg2Of expression,as
R5279 T7090 T7089 arg1Of expression,the
R5280 T7090 T7091 arg1Of expression,of
R5281 T7093 T7091 arg2Of protein,of
R5282 T7093 T7092 arg1Of protein,TLR4
R5283 T7093 T7094 arg1Of protein,after
R5284 T7095 T7094 arg2Of ICH,after
R5285 T7097 T7081 arg2Of elevated,showed
R5286 T7097 T7082 arg1Of elevated,that
R5287 T7097 T7096 arg1Of elevated,significantly
R5288 T7097 T7098 arg1Of elevated,in
R5289 T7100 T7098 arg2Of tissue,in
R5290 T7100 T7099 arg1Of tissue,brain
R5291 T7102 T7101 arg1Of changes,These
R5292 T7102 T7103 arg1Of changes,started
R5293 T7102 T7114 arg1Of changes,maintained
R5294 T7103 T7105 arg1Of started,early
R5295 T7103 T7109 arg1Of started,after
R5296 T7103 T7113 arg1Of started,and
R5297 T7105 T7104 arg1Of early,as
R5298 T7105 T7106 arg1Of early,as
R5299 T7108 T7106 arg2Of hours,as
R5300 T7108 T7107 arg1Of hours,6
R5301 T7112 T7109 arg2Of insult,after
R5302 T7112 T7110 arg1Of insult,the
R5303 T7112 T7111 arg1Of insult,ICH
R5304 T7114 T7113 arg2Of maintained,and
R5305 T7114 T7115 arg1Of maintained,at
R5306 T7114 T7119 arg1Of maintained,for
R5307 T7118 T7115 arg2Of level,at
R5308 T7118 T7116 arg1Of level,a
R5309 T7118 T7117 arg1Of level,high
R5310 T7121 T7119 arg2Of days,for
R5311 T7121 T7120 arg1Of days,7
R5312 T7121 T7122 arg1Of days,afterward
R5313 T7125 T7123 arg1Of protein,The
R5314 T7125 T7124 arg1Of protein,TLR4
R5315 T7125 T7126 arg1Of protein,","
R5316 T7125 T7127 arg2Of protein,detected
R5317 T7125 T7131 arg1Of protein,was
R5318 T7125 T7133 arg2Of protein,distributed
R5319 T7129 T7127 arg1Of immunohistochemistry,detected
R5320 T7129 T7128 arg2Of immunohistochemistry,by
R5321 T7133 T7130 arg1Of distributed,","
R5322 T7133 T7131 arg2Of distributed,was
R5323 T7133 T7132 arg1Of distributed,consistently
R5324 T7133 T7134 arg1Of distributed,in
R5325 T7136 T7135 arg1Of areas,peri-hemorrhage
R5326 T7136 T7137 arg1Of areas,","
R5327 T7136 T7146 arg1Of areas,and
R5328 T7139 T7138 arg1Of hippocampus,the
R5329 T7139 T7140 arg1Of hippocampus,","
R5330 T7139 T7142 arg1Of hippocampus,","
R5331 T7141 T7140 arg2Of cortex,","
R5332 T7142 T7137 arg2Of ",",","
R5333 T7144 T7142 arg2Of nuclei,","
R5334 T7144 T7143 arg1Of nuclei,thalamic
R5335 T7146 T7134 arg2Of and,in
R5336 T7146 T7145 arg1Of and,","
R5337 T7150 T7146 arg2Of tracts,and
R5338 T7150 T7147 arg1Of tracts,some
R5339 T7150 T7148 arg1Of tracts,white
R5340 T7150 T7149 arg1Of tracts,matter
R5341 T7152 T7151 arg1Of data,These
R5342 T7152 T7153 arg1Of data,indicated
R5343 T7156 T7155 arg2Of expression,increased
R5344 T7156 T7157 arg1Of expression,of
R5345 T7156 T7159 arg1Of expression,may
R5346 T7156 T7160 arg1Of expression,be
R5347 T7156 T7161 arg1Of expression,related
R5348 T7158 T7157 arg2Of TLR4,of
R5349 T7160 T7153 arg2Of be,indicated
R5350 T7160 T7154 arg1Of be,that
R5351 T7160 T7159 arg2Of be,may
R5352 T7161 T7160 arg2Of related,be
R5353 T7161 T7162 arg1Of related,to
R5354 T7164 T7162 arg2Of triggering,to
R5355 T7164 T7163 arg1Of triggering,the
R5356 T7164 T7165 arg1Of triggering,of
R5357 T7168 T7165 arg2Of responses,of
R5358 T7168 T7166 arg1Of responses,the
R5359 T7168 T7167 arg1Of responses,inflammatory
R5360 T7168 T7169 arg1Of responses,in
R5361 T7172 T7169 arg2Of tissue,in
R5362 T7172 T7170 arg1Of tissue,the
R5363 T7172 T7171 arg1Of tissue,brain
R5364 T7172 T7173 arg1Of tissue,after
R5365 T7174 T7173 arg2Of ICH,after
R5366 T7176 T7175 arg1Of studies,Recent
R5367 T7176 T7177 arg1Of studies,demonstrated
R5368 T7179 T7180 arg1Of ICH,initiates
R5369 T7180 T7177 arg2Of initiates,demonstrated
R5370 T7180 T7178 arg1Of initiates,that
R5371 T7182 T7180 arg2Of responses,initiates
R5372 T7182 T7181 arg1Of responses,inflammatory
R5373 T7182 T7183 arg1Of responses,","
R5374 T7182 T7184 arg1Of responses,which
R5375 T7182 T7185 arg1Of responses,are
R5376 T7182 T7186 arg2Of responses,associated
R5377 T7186 T7185 arg2Of associated,are
R5378 T7186 T7187 arg1Of associated,with
R5379 T7189 T7188 arg1Of growth,secondary
R5380 T7189 T7190 arg1Of growth,of
R5381 T7189 T7192 arg1Of growth,and
R5382 T7191 T7190 arg2Of hemorrhage,of
R5383 T7192 T7187 arg2Of and,with
R5384 T7194 T7192 arg2Of death,and
R5385 T7194 T7193 arg1Of death,cell
R5386 T7194 T7195 arg1Of death,[
R5387 T7196 T7195 arg2Of 18,[
R5388 T7197 T7195 arg3Of ],[
R5389 T7198 T7199 arg1Of It,is
R5390 T7198 T7201 arg2Of It,believed
R5391 T7201 T7199 arg2Of believed,is
R5392 T7201 T7200 arg1Of believed,now
R5393 T7204 T7203 arg1Of pathway,TLR4-mediated-NFκB
R5394 T7204 T7205 arg1Of pathway,activates
R5395 T7204 T7207 arg1Of pathway,regulates
R5396 T7205 T7206 arg1Of activates,and
R5397 T7206 T7201 arg3Of and,believed
R5398 T7206 T7202 arg1Of and,that
R5399 T7207 T7206 arg2Of regulates,and
R5400 T7208 T7209 arg1Of immunological,and
R5401 T7210 T7209 arg2Of inflammatory,and
R5402 T7211 T7205 arg2Of responses,activates
R5403 T7211 T7207 arg2Of responses,regulates
R5404 T7211 T7208 arg1Of responses,immunological
R5405 T7211 T7210 arg1Of responses,inflammatory
R5406 T7213 T7212 arg1Of investigate,To
R5407 T7213 T7221 arg1Of investigate,in
R5408 T7215 T7213 arg2Of mechanisms,investigate
R5409 T7215 T7214 arg1Of mechanisms,the
R5410 T7215 T7216 arg1Of mechanisms,underlying
R5411 T7220 T7216 arg2Of responses,underlying
R5412 T7220 T7217 arg1Of responses,the
R5413 T7220 T7218 arg2Of responses,increased
R5414 T7220 T7219 arg1Of responses,inflammatory
R5415 T7223 T7221 arg2Of brain,in
R5416 T7223 T7222 arg1Of brain,the
R5417 T7223 T7224 arg1Of brain,after
R5418 T7225 T7224 arg2Of ICH,after
R5419 T7230 T7227 arg2Of study,in
R5420 T7230 T7228 arg1Of study,the
R5421 T7230 T7229 arg1Of study,present
R5422 T7232 T7213 arg1Of we,investigate
R5423 T7232 T7233 arg1Of we,evaluated
R5424 T7232 T7241 arg1Of we,detecting
R5425 T7233 T7212 modOf evaluated,To
R5426 T7233 T7226 arg1Of evaluated,","
R5427 T7233 T7227 arg1Of evaluated,in
R5428 T7233 T7231 arg1Of evaluated,","
R5429 T7233 T7240 arg1Of evaluated,by
R5430 T7235 T7233 arg2Of activation,evaluated
R5431 T7235 T7234 arg1Of activation,the
R5432 T7235 T7236 arg1Of activation,of
R5433 T7239 T7236 arg2Of signaling,of
R5434 T7239 T7237 arg1Of signaling,TLR4-mediated
R5435 T7239 T7238 arg1Of signaling,NFκB
R5436 T7241 T7240 arg2Of detecting,by
R5437 T7241 T7249 arg1Of detecting,in
R5438 T7243 T7242 arg1Of p-IκB,the
R5439 T7243 T7244 arg1Of p-IκB,and
R5440 T7244 T7241 arg2Of and,detecting
R5441 T7246 T7244 arg2Of activity,and
R5442 T7246 T7245 arg1Of activity,the
R5443 T7246 T7247 arg1Of activity,of
R5444 T7248 T7247 arg2Of NFκB,of
R5445 T7251 T7249 arg2Of brains,in
R5446 T7251 T7250 arg1Of brains,hemorrhagic
R5447 T7252 T7253 arg1Of NFκB,is
R5448 T7253 T7258 arg1Of is,downstream
R5449 T7253 T7259 arg1Of is,in
R5450 T7257 T7253 arg2Of factor,is
R5451 T7257 T7254 arg1Of factor,an
R5452 T7257 T7255 arg1Of factor,important
R5453 T7257 T7256 arg1Of factor,transcription
R5454 T7263 T7259 arg2Of pathway,in
R5455 T7263 T7260 arg1Of pathway,the
R5456 T7263 T7261 arg1Of pathway,TLR4-mediated
R5457 T7263 T7262 arg1Of pathway,signaling
R5458 T7264 T7265 arg1Of Activation,of
R5459 T7264 T7267 arg1Of Activation,stimulates
R5460 T7266 T7265 arg2Of TLR4,of
R5461 T7267 T7272 arg1Of stimulates,","
R5462 T7267 T7273 modOf stimulates,resulting
R5463 T7269 T7270 arg1Of phosphorylation,and
R5464 T7270 T7267 arg2Of and,stimulates
R5465 T7270 T7268 arg1Of and,IκBα
R5466 T7271 T7270 arg2Of degradation,and
R5467 T7273 T7274 arg1Of resulting,in
R5468 T7276 T7274 arg2Of translocation,in
R5469 T7276 T7275 arg1Of translocation,nuclear
R5470 T7276 T7277 arg1Of translocation,of
R5471 T7276 T7279 arg1Of translocation,","
R5472 T7276 T7280 arg1Of translocation,which
R5473 T7276 T7281 arg1Of translocation,initiates
R5474 T7278 T7277 arg2Of NFκB,of
R5475 T7282 T7281 arg2Of transcription,initiates
R5476 T7282 T7283 arg1Of transcription,of
R5477 T7284 T7285 arg2Of genes,associated
R5478 T7284 T7290 arg1Of genes,and
R5479 T7285 T7286 arg1Of associated,with
R5480 T7289 T7286 arg2Of responses,with
R5481 T7289 T7287 arg1Of responses,innate
R5482 T7289 T7288 arg1Of responses,immune
R5483 T7290 T7283 arg2Of and,of
R5484 T7291 T7290 arg2Of inflammation,and
R5485 T7291 T7292 arg1Of inflammation,[
R5486 T7293 T7292 arg2Of 5,[
R5487 T7293 T7294 arg1Of 5,","
R5488 T7295 T7294 arg2Of 6,","
R5489 T7296 T7292 arg3Of ],[
R5490 T7297 T7298 arg1Of We,observed
R5491 T7301 T7300 arg1Of levels,the
R5492 T7301 T7302 arg1Of levels,of
R5493 T7301 T7311 arg1Of levels,were
R5494 T7301 T7313 arg2Of levels,increased
R5495 T7303 T7304 arg1Of phosphorylation,of
R5496 T7303 T7306 arg1Of phosphorylation,and
R5497 T7305 T7304 arg2Of IκB,of
R5498 T7306 T7302 arg2Of and,of
R5499 T7308 T7306 arg2Of activity,and
R5500 T7308 T7307 arg1Of activity,the
R5501 T7308 T7309 arg1Of activity,of
R5502 T7310 T7309 arg2Of NFκB,of
R5503 T7313 T7298 arg2Of increased,observed
R5504 T7313 T7299 arg1Of increased,that
R5505 T7313 T7311 arg2Of increased,were
R5506 T7313 T7312 arg1Of increased,significantly
R5507 T7313 T7314 arg1Of increased,in
R5508 T7316 T7314 arg2Of tissue,in
R5509 T7316 T7315 arg1Of tissue,brain
R5510 T7316 T7317 arg1Of tissue,after
R5511 T7318 T7317 arg2Of ICH,after
R5512 T7321 T7319 arg1Of profile,The
R5513 T7321 T7320 arg1Of profile,temporal
R5514 T7321 T7322 arg1Of profile,of
R5515 T7321 T7327 arg1Of profile,and
R5516 T7324 T7322 arg2Of expression,of
R5517 T7324 T7323 arg1Of expression,the
R5518 T7324 T7325 arg1Of expression,of
R5519 T7326 T7325 arg2Of p-IκB,of
R5520 T7327 T7332 arg1Of and,was
R5521 T7327 T7333 arg1Of and,similar
R5522 T7329 T7327 arg2Of activation,and
R5523 T7329 T7328 arg1Of activation,the
R5524 T7329 T7330 arg1Of activation,of
R5525 T7331 T7330 arg2Of NFκB,of
R5526 T7333 T7332 arg2Of similar,was
R5527 T7333 T7334 arg1Of similar,to
R5528 T7335 T7334 arg2Of that,to
R5529 T7335 T7336 arg1Of that,of
R5530 T7338 T7336 arg2Of expression,of
R5531 T7338 T7337 arg1Of expression,the
R5532 T7338 T7339 arg1Of expression,of
R5533 T7340 T7339 arg2Of TLR4,of
R5534 T7342 T7341 arg1Of data,Our
R5535 T7342 T7343 arg1Of data,suggest
R5536 T7345 T7346 arg1Of ICH,stimulates
R5537 T7346 T7343 arg2Of stimulates,suggest
R5538 T7346 T7344 arg1Of stimulates,that
R5539 T7347 T7346 arg2Of activation,stimulates
R5540 T7347 T7348 arg1Of activation,of
R5541 T7352 T7348 arg2Of pathway,of
R5542 T7352 T7349 arg1Of pathway,the
R5543 T7352 T7350 arg1Of pathway,TLR4/NFκB
R5544 T7352 T7351 arg1Of pathway,signaling
R5545 T7352 T7353 arg1Of pathway,","
R5546 T7352 T7354 arg1Of pathway,which
R5547 T7352 T7355 arg1Of pathway,is
R5548 T7352 T7356 arg1Of pathway,consistent
R5549 T7356 T7355 arg2Of consistent,is
R5550 T7356 T7357 arg1Of consistent,with
R5551 T7359 T7357 arg2Of reports,with
R5552 T7359 T7358 arg1Of reports,previous
R5553 T7361 T7362 arg1Of activation,of
R5554 T7361 T7364 arg1Of activation,is
R5555 T7361 T7365 arg2Of activation,regulated
R5556 T7363 T7362 arg2Of NFκB,of
R5557 T7365 T7359 arg2Of regulated,reports
R5558 T7365 T7360 arg1Of regulated,that
R5559 T7365 T7364 arg2Of regulated,is
R5560 T7365 T7366 arg1Of regulated,through
R5561 T7370 T7366 arg2Of pathway,through
R5562 T7370 T7367 arg1Of pathway,the
R5563 T7370 T7368 arg1Of pathway,TLR4-mediated
R5564 T7370 T7369 arg1Of pathway,signaling
R5565 T7371 T7372 arg1Of TLR4,plays
R5566 T7371 T7388 arg1Of TLR4,can
R5567 T7371 T7390 arg1Of TLR4,recognize
R5568 T7372 T7376 arg1Of plays,in
R5569 T7372 T7382 arg1Of plays,[
R5570 T7372 T7387 arg1Of plays,and
R5571 T7375 T7372 arg2Of role,plays
R5572 T7375 T7373 arg1Of role,an
R5573 T7375 T7374 arg1Of role,important
R5574 T7378 T7376 arg2Of recognition,in
R5575 T7378 T7377 arg1Of recognition,the
R5576 T7378 T7379 arg1Of recognition,of
R5577 T7381 T7379 arg2Of components,of
R5578 T7381 T7380 arg1Of components,microbial
R5579 T7383 T7384 arg1Of 19,","
R5580 T7384 T7382 arg2Of ",",[
R5581 T7385 T7384 arg2Of 20,","
R5582 T7386 T7382 arg3Of ],[
R5583 T7390 T7387 arg2Of recognize,and
R5584 T7390 T7388 arg2Of recognize,can
R5585 T7390 T7389 arg1Of recognize,also
R5586 T7392 T7391 arg1Of molecules,endogenous
R5587 T7392 T7394 arg1Of molecules,as
R5588 T7392 T7405 arg1Of molecules,","
R5589 T7394 T7393 arg1Of as,such
R5590 T7397 T7394 arg2Of products,as
R5591 T7397 T7395 arg1Of products,the
R5592 T7397 T7396 arg1Of products,degradation
R5593 T7397 T7398 arg1Of products,of
R5594 T7397 T7400 arg1Of products,","
R5595 T7399 T7398 arg2Of macromolecules,of
R5596 T7401 T7400 arg2Of products,","
R5597 T7401 T7402 arg1Of products,of
R5598 T7404 T7402 arg2Of cascades,of
R5599 T7404 T7403 arg1Of cascades,proteolytic
R5600 T7405 T7412 arg1Of ",",and
R5601 T7407 T7405 arg2Of components,","
R5602 T7407 T7406 arg1Of components,intracellular
R5603 T7407 T7408 arg1Of components,of
R5604 T7410 T7408 arg2Of cells,of
R5605 T7410 T7409 arg1Of cells,ruptured
R5606 T7412 T7390 arg2Of and,recognize
R5607 T7412 T7411 arg1Of and,","
R5608 T7413 T7412 arg2Of products,and
R5609 T7413 T7414 arg1Of products,of
R5610 T7415 T7414 arg2Of genes,of
R5611 T7415 T7416 arg1Of genes,that
R5612 T7415 T7417 arg1Of genes,are
R5613 T7415 T7418 arg2Of genes,activated
R5614 T7418 T7417 arg2Of activated,are
R5615 T7420 T7418 arg1Of inflammation,activated
R5616 T7420 T7419 arg2Of inflammation,by
R5617 T7422 T7421 arg2Of instance,For
R5618 T7424 T7425 arg1Of HSP70,","
R5619 T7425 T7427 arg1Of ",",","
R5620 T7426 T7425 arg2Of HSP32,","
R5621 T7427 T7430 arg1Of ",",and
R5622 T7428 T7427 arg2Of HSP27,","
R5623 T7430 T7429 arg1Of and,","
R5624 T7430 T7436 arg1Of and,are
R5625 T7430 T7437 arg2Of and,found
R5626 T7430 T7439 arg1Of and,be
R5627 T7430 T7440 arg2Of and,upregulated
R5628 T7431 T7430 arg2Of enzymes,and
R5629 T7431 T7432 arg2Of enzymes,involved
R5630 T7432 T7433 arg1Of involved,in
R5631 T7435 T7433 arg2Of stress,in
R5632 T7435 T7434 arg1Of stress,oxidative
R5633 T7437 T7421 arg1Of found,For
R5634 T7437 T7423 arg1Of found,","
R5635 T7437 T7436 arg2Of found,are
R5636 T7440 T7437 arg3Of upregulated,found
R5637 T7440 T7438 arg1Of upregulated,to
R5638 T7440 T7439 arg2Of upregulated,be
R5639 T7440 T7441 arg1Of upregulated,in
R5640 T7443 T7441 arg2Of brain,in
R5641 T7443 T7442 arg1Of brain,the
R5642 T7443 T7444 arg1Of brain,after
R5643 T7443 T7446 arg1Of brain,","
R5644 T7443 T7447 arg1Of brain,which
R5645 T7443 T7448 arg1Of brain,may
R5646 T7443 T7449 arg1Of brain,be
R5647 T7443 T7450 arg2Of brain,produced
R5648 T7445 T7444 arg2Of ICH,after
R5649 T7450 T7448 arg2Of produced,may
R5650 T7450 T7449 arg2Of produced,be
R5651 T7454 T7452 arg2Of cells,injured
R5652 T7454 T7453 arg1Of cells,neuronal
R5653 T7454 T7455 arg1Of cells,or
R5654 T7455 T7450 arg1Of or,produced
R5655 T7455 T7451 arg2Of or,by
R5656 T7457 T7455 arg2Of cells,or
R5657 T7457 T7456 arg1Of cells,blood
R5658 T7457 T7458 arg1Of cells,[
R5659 T7459 T7458 arg2Of 21,[
R5660 T7460 T7458 arg3Of ],[
R5661 T7467 T7466 arg1Of molecules,these
R5662 T7467 T7468 arg2Of molecules,produced
R5663 T7467 T7473 arg1Of molecules,came
R5664 T7467 T7487 arg1Of molecules,activate
R5665 T7468 T7469 arg1Of produced,in
R5666 T7471 T7469 arg2Of brain,in
R5667 T7471 T7470 arg2Of brain,damaged
R5668 T7471 T7472 arg1Of brain,or
R5669 T7473 T7474 arg1Of came,from
R5670 T7473 T7482 arg1Of came,as
R5671 T7473 T7486 arg1Of came,","
R5672 T7476 T7475 arg1Of cells,blood
R5673 T7476 T7477 arg1Of cells,and
R5674 T7477 T7474 arg2Of and,from
R5675 T7478 T7477 arg2Of constituents,and
R5676 T7478 T7479 arg1Of constituents,of
R5677 T7481 T7479 arg2Of server,of
R5678 T7481 T7480 arg1Of server,plasma
R5679 T7485 T7482 arg2Of ligands,as
R5680 T7485 T7483 arg1Of ligands,endogenous
R5681 T7485 T7484 arg1Of ligands,TLR4
R5682 T7486 T7464 arg2Of ",",speculated
R5683 T7486 T7465 arg1Of ",",that
R5684 T7487 T7486 arg2Of activate,","
R5685 T7490 T7487 arg2Of signaling,activate
R5686 T7490 T7488 arg1Of signaling,TLR4-mediated
R5687 T7490 T7489 arg1Of signaling,NFκB
R5688 T7492 T7491 arg1Of and,","
R5689 T7493 T7492 arg2Of initiate,and
R5690 T7496 T7493 arg2Of responses,initiate
R5691 T7496 T7494 arg1Of responses,the
R5692 T7496 T7495 arg1Of responses,inflammatory
R5693 T7496 T7497 arg1Of responses,in
R5694 T7499 T7497 arg2Of brain,in
R5695 T7499 T7498 arg1Of brain,IHC
R5696 T7505 T7502 arg1Of ligands,the
R5697 T7505 T7503 arg1Of ligands,specific
R5698 T7505 T7504 arg1Of ligands,endogenous
R5699 T7505 T7506 arg1Of ligands,for
R5700 T7505 T7511 arg1Of ligands,have
R5701 T7505 T7513 arg1Of ligands,been
R5702 T7505 T7514 arg2Of ligands,determined
R5703 T7505 T7516 arg1Of ligands,need
R5704 T7505 T7518 arg1Of ligands,be
R5705 T7505 T7519 arg2Of ligands,identified
R5706 T7507 T7506 arg2Of TLR4,for
R5707 T7507 T7508 arg1Of TLR4,in
R5708 T7510 T7508 arg2Of brain,in
R5709 T7510 T7509 arg1Of brain,hemorrhagic
R5710 T7514 T7511 arg2Of determined,have
R5711 T7514 T7512 arg1Of determined,not
R5712 T7514 T7513 arg2Of determined,been
R5713 T7514 T7515 arg1Of determined,and
R5714 T7515 T7500 arg1Of and,However
R5715 T7515 T7501 arg1Of and,","
R5716 T7516 T7515 arg2Of need,and
R5717 T7519 T7516 arg2Of identified,need
R5718 T7519 T7517 arg1Of identified,to
R5719 T7519 T7518 arg2Of identified,be
R5720 T7519 T7520 arg1Of identified,through
R5721 T7522 T7520 arg2Of research,through
R5722 T7522 T7521 arg1Of research,further
R5723 T7524 T7523 arg2Of conclusion,In
R5724 T7528 T7526 arg1Of study,the
R5725 T7528 T7527 arg1Of study,present
R5726 T7528 T7529 arg1Of study,demonstrated
R5727 T7529 T7523 arg1Of demonstrated,In
R5728 T7529 T7525 arg1Of demonstrated,","
R5729 T7532 T7529 arg2Of profile,demonstrated
R5730 T7532 T7530 arg1Of profile,the
R5731 T7532 T7531 arg1Of profile,temporal
R5732 T7532 T7533 arg1Of profile,of
R5733 T7535 T7533 arg2Of activation,of
R5734 T7535 T7534 arg1Of activation,the
R5735 T7535 T7536 arg1Of activation,of
R5736 T7535 T7540 arg1Of activation,in
R5737 T7535 T7543 arg1Of activation,in
R5738 T7535 T7550 arg1Of activation,","
R5739 T7535 T7551 arg1Of activation,which
R5740 T7535 T7552 arg1Of activation,suggests
R5741 T7539 T7536 arg2Of signaling,of
R5742 T7539 T7537 arg1Of signaling,TLR4-mediated
R5743 T7539 T7538 arg1Of signaling,NFκB
R5744 T7542 T7540 arg2Of tissue,in
R5745 T7542 T7541 arg1Of tissue,brain
R5746 T7546 T7543 arg2Of model,in
R5747 T7546 T7544 arg1Of model,a
R5748 T7546 T7545 arg1Of model,rat
R5749 T7546 T7547 arg1Of model,of
R5750 T7549 T7547 arg2Of ICH,of
R5751 T7549 T7548 arg1Of ICH,experimental
R5752 T7556 T7554 arg1Of signaling,TLR4-mediated
R5753 T7556 T7555 arg1Of signaling,NFκB
R5754 T7556 T7557 arg1Of signaling,participates
R5755 T7557 T7552 arg2Of participates,suggests
R5756 T7557 T7553 arg1Of participates,that
R5757 T7557 T7558 arg1Of participates,in
R5758 T7560 T7558 arg2Of pathogenesis,in
R5759 T7560 T7559 arg1Of pathogenesis,the
R5760 T7560 T7561 arg1Of pathogenesis,of
R5761 T7560 T7563 arg1Of pathogenesis,","
R5762 T7560 T7564 arg1Of pathogenesis,which
R5763 T7560 T7565 arg1Of pathogenesis,may
R5764 T7560 T7566 arg1Of pathogenesis,be
R5765 T7562 T7561 arg2Of ICH,of
R5766 T7566 T7565 arg2Of be,may
R5767 T7569 T7566 arg2Of target,be
R5768 T7569 T7567 arg1Of target,a
R5769 T7569 T7568 arg1Of target,therapeutic
R5770 T7569 T7570 arg1Of target,for
R5771 T7572 T7570 arg2Of prevention,for
R5772 T7572 T7571 arg1Of prevention,the
R5773 T7572 T7573 arg1Of prevention,of
R5774 T7576 T7573 arg2Of damage,of
R5775 T7576 T7574 arg1Of damage,ICH-induced
R5776 T7576 T7575 arg1Of damage,brain

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T6288 17577-17592 Anaphor denotes these molecules
T6287 17382-17387 Antecedent denotes HSP27
T6286 17375-17380 Antecedent denotes HSP32
T6285 17368-17373 Antecedent denotes HSP70
T6284 17482-17487 Anaphor denotes which
T6283 15276-15284 Antecedent denotes elevated
T6282 15302-15315 Anaphor denotes These changes
R4668 T6282 T6283 boundBy These changes,elevated
R4669 T6284 T6285 boundBy which,HSP70
R4670 T6284 T6286 boundBy which,HSP32
R4671 T6284 T6287 boundBy which,HSP27
R4672 T6288 T6285 boundBy these molecules,HSP70
R4673 T6288 T6286 boundBy these molecules,HSP32
R4674 T6288 T6287 boundBy these molecules,HSP27

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T6312 18136-18140 Protein denotes TLR4
T6311 18035-18039 Protein denotes TLR4
T6310 17844-17848 Protein denotes TLR4
T6309 17715-17719 Protein denotes TLR4
T6308 17692-17696 Protein denotes TLR4
T6307 17382-17387 Protein denotes HSP27
T6306 17375-17380 Protein denotes HSP32
T6305 17368-17373 Protein denotes HSP70
T6304 17041-17045 Protein denotes TLR4
T6303 17008-17012 Protein denotes TLR4
T6302 16888-16892 Protein denotes TLR4
T6301 16827-16831 Protein denotes TLR4
T6300 16390-16394 Protein denotes IκBα
T6299 16374-16378 Protein denotes TLR4
T6298 16327-16331 Protein denotes TLR4
T6297 16167-16171 Protein denotes TLR4
T6296 15919-15923 Protein denotes TLR4
T6295 15647-15651 Protein denotes TLR4
T6294 15422-15426 Protein denotes TLR4
T6293 15239-15243 Protein denotes TLR4
T6292 15205-15209 Protein denotes TLR4
T6291 15144-15148 Protein denotes TLR4
T6290 15018-15022 Protein denotes TLR4
T6289 14523-14527 Protein denotes TLR4
T5620 11595-11599 Protein denotes TLR4
T5619 11325-11329 Protein denotes TLR4
T5618 11276-11280 Protein denotes TLR4
T5378 11112-11116 Protein denotes TLR4
T5377 10995-10999 Protein denotes TLR4
T5376 10926-10930 Protein denotes TLR4
T3726 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3725 8250-8255 Protein denotes GAPDH
T2770 7266-7270 Protein denotes TLR4
T2769 6875-6882 Protein denotes β-actin
T2768 6786-6790 Protein denotes TLR4
T2767 6742-6749 Protein denotes β-actin
T2766 6733-6737 Protein denotes TLR4
T2765 6635-6642 Protein denotes β-actin
T2764 6614-6633 Protein denotes The house keep gene
T2763 6594-6612 Protein denotes Taq DNA polymerase
T2762 6494-6498 Protein denotes TLR4
T2761 5834-5838 Protein denotes TLR4
T4927 10803-10807 Protein denotes TLR4
T4926 10742-10746 Protein denotes TLR4
T4925 10515-10519 Protein denotes TLR4
T4924 10440-10444 Protein denotes TLR4
T4923 10395-10399 Protein denotes TLR4
T4922 10292-10296 Protein denotes TLR4
T4921 10247-10251 Protein denotes TLR4
T4920 10169-10173 Protein denotes TLR4
T4019 9271-9274 Protein denotes P50
T4018 9263-9266 Protein denotes P65
T867 3474-3478 Protein denotes TLR4
T866 3423-3427 Protein denotes TLR4
T865 3284-3288 Protein denotes TLR4
T864 3252-3256 Protein denotes TLR4
T863 3168-3172 Protein denotes TLR4
T862 2944-2948 Protein denotes TLR4
T861 2449-2453 Protein denotes TLR4
T3521 7559-7565 Protein denotes avidin
T3520 7387-7391 Protein denotes TLR4
T90 14-18 Protein denotes TLR4
T91 183-203 Protein denotes Toll-like receptor 4
T5375 10908-10912 Protein denotes TLR4
T5374 10846-10850 Protein denotes TLR4
T92 206-210 Protein denotes TLR4
T93 388-392 Protein denotes TLR4
T94 537-541 Protein denotes TLR4
T95 564-568 Protein denotes TLR4
T96 636-640 Protein denotes TLR4
T97 682-703 Protein denotes inhibitors of kappa B
T98 707-711 Protein denotes IκBα
T99 885-889 Protein denotes TLR4
T100 1104-1108 Protein denotes IκBα
T101 1242-1246 Protein denotes TLR4
T4523 9888-9892 Protein denotes TLR4
T4522 9790-9794 Protein denotes TLR4
T4521 9706-9710 Protein denotes TLR4
T4520 9647-9651 Protein denotes TLR4
T4519 9601-9605 Protein denotes TLR4
T2772 7319-7326 Protein denotes β-actin
T2771 7306-7310 Protein denotes TLR4

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T8669 17382-17387 http://www.uniprot.org/uniprot/P04792 denotes HSP27
T8668 16390-16394 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T8667 18136-18140 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8666 18035-18039 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8665 17844-17848 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8664 17715-17719 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8663 17692-17696 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8662 17041-17045 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8661 17008-17012 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8660 16888-16892 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8659 16827-16831 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8658 16374-16378 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8657 16327-16331 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8656 16167-16171 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8655 15919-15923 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8654 15647-15651 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8653 15422-15426 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8652 15239-15243 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8651 15205-15209 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8650 15144-15148 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8649 15018-15022 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T8648 14523-14527 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5541 11112-11116 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5540 10995-10999 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5539 10926-10930 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5538 10908-10912 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5537 10846-10850 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5221 10803-10807 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5220 10742-10746 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5219 10515-10519 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5218 10440-10444 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5217 10395-10399 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5216 10292-10296 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5215 10247-10251 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5214 10169-10173 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T4776 9888-9892 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T4775 9790-9794 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T4774 9706-9710 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T4773 9647-9651 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T4772 9601-9605 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T4771 9596-9599 http://www.uniprot.org/uniprot/Q8IX06 denotes 3.1
T4770 9596-9599 http://www.uniprot.org/uniprot/Q5D1E8 denotes 3.1
T4769 9596-9599 http://www.uniprot.org/uniprot/Q5D1E7 denotes 3.1
T3959 8272-8297 http://www.uniprot.org/uniprot/P04406 denotes 3-phosphate dehydrogenase
T3958 8250-8255 http://www.uniprot.org/uniprot/P04406 denotes GAPDH
T3676 7387-7391 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3383 7319-7326 http://www.uniprot.org/uniprot/P60709 denotes β-actin
T3382 6875-6882 http://www.uniprot.org/uniprot/P60709 denotes β-actin
T3381 6742-6749 http://www.uniprot.org/uniprot/P60709 denotes β-actin
T3380 6635-6642 http://www.uniprot.org/uniprot/P60709 denotes β-actin
T3379 7306-7310 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3378 7266-7270 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3377 6786-6790 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5958 11595-11599 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5957 11325-11329 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T5956 11276-11280 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3376 6733-6737 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3375 6494-6498 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3374 5834-5838 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1656 3474-3478 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1655 3423-3427 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1654 3284-3288 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1653 3252-3256 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1652 3168-3172 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1651 2944-2948 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T1650 2449-2453 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T625 206-210 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T626 388-392 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T627 537-541 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T628 564-568 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T629 636-640 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T630 885-889 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T631 1242-1246 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T624 14-18 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3677 7481-7485 http://www.uniprot.org/uniprot/O00206 denotes TLR4

UBERON-AE

Id Subject Object Predicate Lexical cue
T56 58-63 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T6192 15576-15588 http://purl.obolibrary.org/obo/UBERON_0002316 denotes white matter
T6191 15542-15548 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T6190 14609-14616 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T6189 17632-17637 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6188 17533-17538 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6187 14884-14889 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6186 12745-12750 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6185 12537-12542 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6184 18073-18079 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6183 16693-16699 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6182 15728-15734 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6181 15294-15300 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6180 13288-13294 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6179 12577-12583 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6178 12462-12468 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6177 18274-18279 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6176 18067-18072 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6175 17864-17869 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6174 17792-17797 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6173 17613-17618 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6172 17465-17470 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6171 16687-16692 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6170 16097-16102 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6169 15722-15727 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6168 15288-15293 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6167 14204-14209 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6166 13568-13573 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6165 13282-13287 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6164 12959-12964 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6163 12820-12825 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6162 12770-12775 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6161 12571-12576 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T6160 12456-12461 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T5361 11224-11236 http://purl.obolibrary.org/obo/UBERON_0002316 denotes white matter
T5360 11190-11196 http://purl.obolibrary.org/obo/UBERON_0001851 denotes cortex
T5359 11045-11051 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T5358 11039-11044 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T5357 10854-10859 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T4898 10327-10333 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T4897 10201-10207 http://purl.obolibrary.org/obo/UBERON_0000479 denotes Tissue
T4896 10321-10326 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T4895 10195-10200 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T4504 9749-9755 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T4503 9630-9636 http://purl.obolibrary.org/obo/UBERON_0000479 denotes Tissue
T4502 9743-9748 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T4501 9624-9629 http://purl.obolibrary.org/obo/UBERON_0000955 denotes Brain
T4005 8955-8959 http://purl.obolibrary.org/obo/UBERON_0000025 denotes tube
T4004 8789-8794 http://purl.obolibrary.org/obo/UBERON_0000025 denotes tubes
T4003 8681-8686 http://purl.obolibrary.org/obo/UBERON_0000025 denotes tubes
T4002 8548-8554 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T4001 8542-8547 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T3715 7811-7831 http://purl.obolibrary.org/obo/UBERON_0001869 denotes cerebral hemispheres
T2236 5490-5495 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2235 5731-5738 http://purl.obolibrary.org/obo/UBERON_4200215 denotes sutures
T2234 5244-5250 http://purl.obolibrary.org/obo/UBERON_4200215 denotes suture
T2233 5236-5250 http://purl.obolibrary.org/obo/UBERON_0002489 denotes coronal suture
T2232 5218-5223 http://purl.obolibrary.org/obo/UBERON_0003129 denotes skull
T2231 5119-5124 http://purl.obolibrary.org/obo/UBERON_0000403 denotes scalp
T1764 4598-4604 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T1763 4387-4393 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T1762 4127-4132 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T837 3021-3040 http://purl.obolibrary.org/obo/UBERON_0000120 denotes blood brain barrier
T836 3021-3026 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T835 3511-3517 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T834 1798-1804 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T833 1662-1668 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T832 3505-3510 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T831 3180-3185 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T830 3096-3101 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T829 3049-3054 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T828 3027-3032 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T827 2883-2888 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T826 1994-1999 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T825 1838-1843 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T824 1792-1797 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T823 1697-1702 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T822 1656-1661 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T62 777-783 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T61 602-609 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T60 1366-1371 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T59 1156-1161 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T58 596-601 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T57 353-358 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain

GO-BP

Id Subject Object Predicate Lexical cue
T6392 17022-17045 http://purl.obolibrary.org/obo/GO_0034143 denotes signaling pathway. TLR4
T6391 17022-17045 http://purl.obolibrary.org/obo/GO_0034142 denotes signaling pathway. TLR4
T6390 16607-16629 http://purl.obolibrary.org/obo/GO_0007252 denotes phosphorylation of IκB
T6389 16527-16550 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune responses
T6388 16527-16550 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune responses
T6387 16527-16550 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune responses
T6386 16527-16550 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune responses
T6385 16527-16550 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune responses
T6384 16527-16550 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T6383 17178-17189 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6382 16415-16426 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T6381 16607-16622 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6380 16395-16410 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T6379 17013-17039 http://purl.obolibrary.org/obo/GO_0071847 denotes mediated signaling pathway
T6378 16332-16358 http://purl.obolibrary.org/obo/GO_0071847 denotes mediated signaling pathway
T6377 17013-17039 http://purl.obolibrary.org/obo/GO_0070098 denotes mediated signaling pathway
T6376 16332-16358 http://purl.obolibrary.org/obo/GO_0070098 denotes mediated signaling pathway
T6375 17013-17039 http://purl.obolibrary.org/obo/GO_0035689 denotes mediated signaling pathway
T6374 16332-16358 http://purl.obolibrary.org/obo/GO_0035689 denotes mediated signaling pathway
T6373 17013-17039 http://purl.obolibrary.org/obo/GO_0038166 denotes mediated signaling pathway
T6372 16332-16358 http://purl.obolibrary.org/obo/GO_0038166 denotes mediated signaling pathway
T6371 17013-17039 http://purl.obolibrary.org/obo/GO_0038161 denotes mediated signaling pathway
T6370 16332-16358 http://purl.obolibrary.org/obo/GO_0038161 denotes mediated signaling pathway
T6369 17013-17039 http://purl.obolibrary.org/obo/GO_0038007 denotes mediated signaling pathway
T6368 16332-16358 http://purl.obolibrary.org/obo/GO_0038007 denotes mediated signaling pathway
T6367 17013-17039 http://purl.obolibrary.org/obo/GO_0009755 denotes mediated signaling pathway
T6366 16332-16358 http://purl.obolibrary.org/obo/GO_0009755 denotes mediated signaling pathway
T6365 17013-17039 http://purl.obolibrary.org/obo/GO_0019221 denotes mediated signaling pathway
T6364 16332-16358 http://purl.obolibrary.org/obo/GO_0019221 denotes mediated signaling pathway
T6363 17013-17039 http://purl.obolibrary.org/obo/GO_0007229 denotes mediated signaling pathway
T6362 16332-16358 http://purl.obolibrary.org/obo/GO_0007229 denotes mediated signaling pathway
T6361 15938-15969 http://purl.obolibrary.org/obo/GO_1903307 denotes pathway activates and regulates
T6360 15853-15859 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T6359 15843-15859 http://purl.obolibrary.org/obo/GO_0080117 denotes secondary growth
T6358 14339-14351 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T6357 17022-17039 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T6356 16898-16915 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T6355 16341-16358 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T6354 14454-14472 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T6353 14332-14351 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T6352 18155-18164 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6351 18054-18063 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6350 17734-17743 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6349 17022-17031 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6348 16898-16907 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6347 16341-16350 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6346 16186-16195 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6345 15037-15046 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6344 14454-14463 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6343 14332-14338 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T6342 14089-14099 http://purl.obolibrary.org/obo/GO_0007610 denotes behavioral
T6341 15883-15888 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T6340 13945-13950 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T6339 15878-15888 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T6338 13940-13950 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T6337 16534-16550 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T6336 13469-13485 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T6335 16488-16501 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6334 16288-16301 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6333 15188-15201 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6332 13430-13443 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6331 13392-13405 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6330 13317-13330 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T6329 13225-13260 http://purl.obolibrary.org/obo/GO_0050729 denotes inflammatory responses is activated
T6328 13225-13260 http://purl.obolibrary.org/obo/GO_0002675 denotes inflammatory responses is activated
T6327 13225-13260 http://purl.obolibrary.org/obo/GO_0002678 denotes inflammatory responses is activated
T6326 18185-18197 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T6325 13187-13199 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T6324 17340-17352 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6323 16555-16567 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6322 14075-14087 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6321 13552-13564 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6320 13490-13502 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6319 16067-16089 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T6318 15988-16010 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T6317 15793-15815 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T6316 15692-15714 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T6315 13865-13887 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T6314 13225-13247 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T6313 12900-12922 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T5621 11342-11357 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3522 7672-7674 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T2775 6364-6373 http://purl.obolibrary.org/obo/GO_0009058 denotes Synthesis
T2774 6382-6384 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T2773 5861-5863 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T1773 4647-4649 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T883 3014-3019 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T882 2466-2481 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T881 3235-3248 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T880 2630-2643 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T879 2299-2312 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T878 2198-2210 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T877 2191-2210 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T876 3488-3497 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T875 3298-3307 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T874 2265-2274 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T873 2191-2197 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T872 2331-2343 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T871 2755-2777 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T870 2664-2686 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T869 2052-2074 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T868 1762-1784 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T102 82-94 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T103 319-341 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T104 135-147 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T105 424-436 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T106 1291-1303 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T107 252-261 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T108 407-416 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T109 583-592 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T110 1261-1270 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T111 305-315 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T112 305-341 http://purl.obolibrary.org/obo/GO_0002676 denotes regulation of inflammatory responses
T113 305-341 http://purl.obolibrary.org/obo/GO_0050729 denotes regulation of inflammatory responses
T114 305-341 http://purl.obolibrary.org/obo/GO_0050727 denotes regulation of inflammatory responses
T115 305-341 http://purl.obolibrary.org/obo/GO_0050728 denotes regulation of inflammatory responses
T116 305-341 http://purl.obolibrary.org/obo/GO_0002673 denotes regulation of inflammatory responses
T117 650-678 http://purl.obolibrary.org/obo/GO_0006468 denotes protein, the phosphorylation
T118 663-678 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5626 11614-11623 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T5625 11542-11564 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T5624 11508-11521 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T5623 11416-11426 http://purl.obolibrary.org/obo/GO_0008588 denotes NF-kappa-B
T5622 11629-11644 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3729 8369-8376 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T3728 8145-8152 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T3727 7770-7778 http://purl.obolibrary.org/obo/GO_0007349 denotes Cellular

GO-MF

Id Subject Object Predicate Lexical cue
T6398 17832-17839 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T6397 17697-17704 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T6396 13130-13145 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulins
T4023 9249-9259 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4022 9305-9312 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T4021 9085-9092 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T4020 9044-9051 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1774 4647-4649 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T887 2423-2429 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T4928 10380-10390 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3731 8104-8114 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3730 8019-8027 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T3527 7672-7674 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T3526 7710-7720 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3525 7543-7551 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T3524 7530-7538 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T3523 7447-7455 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2777 6382-6384 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T2776 5861-5863 http://purl.obolibrary.org/obo/GO_0003964 denotes RT

GO-CC

Id Subject Object Predicate Lexical cue
T6405 17252-17265 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T6404 17638-17643 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6403 17539-17544 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6402 17524-17529 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6401 17289-17294 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6400 14890-14895 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6399 12826-12831 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4929 10380-10390 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T4930 10380-10390 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4025 9249-9259 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4024 9249-9259 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T3528 7447-7455 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T2251 5446-5453 http://purl.obolibrary.org/obo/GO_0031430 denotes midline
T2250 5271-5278 http://purl.obolibrary.org/obo/GO_0031430 denotes midline
T2249 5147-5154 http://purl.obolibrary.org/obo/GO_0031430 denotes midline
T890 2590-2597 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T889 2157-2170 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane
T888 2157-2170 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T5627 11468-11475 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3738 8104-8114 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T3737 8019-8027 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T3736 8104-8114 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T3735 8019-8027 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T3734 8218-8227 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T3733 7965-7974 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T3732 7909-7918 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T3535 7710-7720 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T3534 7543-7551 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T3533 7530-7538 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T3532 7447-7455 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T3531 7710-7720 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T3530 7543-7551 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T3529 7530-7538 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody

sentences

Id Subject Object Predicate Lexical cue
T6231 17947-18287 Sentence denotes In conclusion, the present study demonstrated the temporal profile of the activation of TLR4-mediated NFκB signaling in brain tissue in a rat model of experimental ICH, which suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may be a therapeutic target for the prevention of ICH-induced brain damage.
T6230 17799-17946 Sentence denotes However, the specific endogenous ligands for TLR4 in hemorrhagic brain have not been determined and need to be identified through further research.
T6229 17551-17798 Sentence denotes It may be speculated that these molecules produced in damaged brain or came from blood cells and constituents of plasma server as endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling, and initiate the inflammatory responses in IHC brain.
T6228 17354-17550 Sentence denotes For instance, HSP70, HSP32, HSP27, and enzymes involved in oxidative stress are found to be upregulated in the brain after ICH, which may be produced by injured neuronal cells or blood cells [21].
T6227 17041-17353 Sentence denotes TLR4 plays an important role in the recognition of microbial components [19, 20] and can also recognize endogenous molecules such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation.
T6226 16833-17040 Sentence denotes Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway, which is consistent with previous reports that activation of NFκB is regulated through the TLR4-mediated signaling pathway.
T6225 16711-16832 Sentence denotes The temporal profile of the expression of p-IκB and the activation of NFκB was similar to that of the expression of TLR4.
T6224 16576-16710 Sentence denotes We observed that the levels of phosphorylation of IκB and the activity of NFκB were significantly increased in brain tissue after ICH.
T6223 16360-16575 Sentence denotes Activation of TLR4 stimulates IκBα phosphorylation and degradation, resulting in nuclear translocation of NFκB, which initiates transcription of genes associated with innate immune responses and inflammation [5, 6].
T6222 16267-16359 Sentence denotes NFκB is an important transcription factor downstream in the TLR4-mediated signaling pathway.
T6221 16012-16266 Sentence denotes To investigate the mechanisms underlying the increased inflammatory responses in the brain after ICH, in the present study, we evaluated the activation of TLR4-mediated NFκB signaling by detecting the p-IκB and the activity of NFκB in hemorrhagic brains.
T6220 15895-16011 Sentence denotes It is now believed that TLR4-mediated-NFκB pathway activates and regulates immunological and inflammatory responses.
T6219 15746-15894 Sentence denotes Recent studies demonstrated that ICH initiates inflammatory responses, which are associated with secondary growth of hemorrhage and cell death [18].
T6218 15597-15745 Sentence denotes These data indicated that increased expression of TLR4 may be related to the triggering of the inflammatory responses in the brain tissue after ICH.
T6217 15418-15596 Sentence denotes The TLR4 protein, detected by immunohistochemistry, was consistently distributed in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts.
T6216 15302-15417 Sentence denotes These changes started as early as 6 hours after the ICH insult and maintained at a high level for 7 days afterward.
T6215 15167-15301 Sentence denotes Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH significantly elevated in brain tissue.
T6214 15056-15166 Sentence denotes In the present study, we established the rat model of experimental ICH and detected the TLR4 mRNA and protein.
T6213 14733-15055 Sentence denotes Although previous reports indicated that the activation of NFκB was attributed to the oxidative stress or glutamate receptor activation induced by red blood cells and/or plasma constituents [17], very few studies have been directed to investigate the role and the relationship between TLR4-mediated NFκB signaling and ICH.
T6212 14523-14732 Sentence denotes TLR4, the first mammalian TLR recognized, has been reported to be involved in several central nervous (CNS) system diseases, such as inflammatory or autoimmune CNS diseases and cerebral ischemic injury [7, 8].
T6211 14441-14522 Sentence denotes TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13].
T6210 14289-14440 Sentence denotes Toll-like receptors (TLRs) are a family of signal transduction molecules and play a critical role in the induction of innate and adaptive immunity [4].
T6209 14155-14288 Sentence denotes The knowledge about how NFκB is activated in the brain subjected to ICH is critical for seeking a new neuroprotective method for ICH.
T6208 13967-14154 Sentence denotes Inhibition of NFκB activity has been shown to have a therapeutic effect on experimental ICH, such as reduce inflammation, behavioral dysfunction, and neuronal damage produced by ICH [17].
T6207 13836-13966 Sentence denotes Activation of NFκB initiates inflammatory responses and contributes to the pathobiology of perilesional cell death after ICH [16].
T6206 13674-13835 Sentence denotes NFκB activation occurs within minutes and persists for at least a week in response to ICH, which is associated with the expression of selected target genes [15].
T6205 13587-13673 Sentence denotes It has been reported that NFκB increased in the region of perihematoma after ICH [14].
T6204 13317-13586 Sentence denotes Transcription factor nuclear factor-kappa-B (NFκB) is an important nuclear transcription factor, which initiates transcription of genes associated with immune responses and inflammation [12, 13] and also plays a key role in regulating inflammation in brain pathologies.
T6203 13208-13316 Sentence denotes However, how the inflammatory responses is activated and regulated in the brain tissue after ICH is unclear.
T6202 13026-13207 Sentence denotes Various constituents of the inflammatory response, including adhesion molecules, cytokines, leukocytes, immunoglobulins, and complement, may be important in the pathogenesis of ICH.
T6201 12896-13025 Sentence denotes The inflammatory responses are responsible for the ICH induced brain injury, which could provide new therapeutic targets for ICH.
T6200 12702-12895 Sentence denotes After ICH, inflammatory mediators from the blood might enter to the brain and induce an inflammatory reaction and the brain cells itself are also capable of producing many of these agents [11].
T6199 12592-12701 Sentence denotes In addition, there is increasing evidence that inflammatory processes are involved in cerebrovascular events.
T6198 12498-12591 Sentence denotes Mass effect, ischemia, and toxicity of blood components after ICH induce brain tissue damage.
T6197 12378-12497 Sentence denotes Unfortunately, the method for treatment of this disease and protection of the brain tissue after ICH are not effective.
T6196 12326-12377 Sentence denotes Only 38% of the patients survive the 1st year [10].
T6195 12275-12325 Sentence denotes Only 31% are functionally independent at 3 months.
T6194 12214-12274 Sentence denotes The mortality of ICH is higher than that of ischemic stroke.
T6193 12039-12213 Sentence denotes Intra-cerebral hemorrhage (ICH) represents 10–15% of all strokes, and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke [1].
T5611 11566-11749 Sentence denotes To detectd the activation of TLR4-mediated NFκB signaling, the phosphorylation of inhibitor of kappa-B (p-IκB) and activity of NFκB were measured by methods of Western Blots and EMSA.
T5610 11435-11565 Sentence denotes Then, NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses.
T5609 11311-11434 Sentence denotes Activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB), which dissociates IκB with NF-kappa-B (NFκB).
T5608 11262-11310 Sentence denotes Activation of TLR4-Mediated NF-Kappa-B Signaling
T5607 11257-11261 Sentence denotes 3.4.
T5366 11082-11255 Sentence denotes However, immunoreactivity for TLR4 was consistently demonstrated in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts (Figure 3).
T5365 10975-11081 Sentence denotes Results showed that TLR4 immunoreactivity was not detectable in brain tissue from normal and sham control.
T5364 10877-10974 Sentence denotes To explore the distribution of TLR4 protein, the TLR4 was detected by immunohistochemistry (IHC).
T5363 10830-10876 Sentence denotes Distribution of TLR4 in Brain Subjected to ICH
T5362 10825-10829 Sentence denotes 3.3.
T4904 10722-10823 Sentence denotes This observation of TLR4 protein was consistent with the temporal profile of the TLR4 mRNA after ICH.
T4903 10497-10721 Sentence denotes The expression of TLR4 significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased but still maintained at a high level on the 7th day after ICH (P < .05, Figure 2).
T4902 10401-10496 Sentence denotes Our results showed that a low level of TLR4 protein was detectable in the saline control group.
T4901 10218-10400 Sentence denotes To investigate the increased TLR4 at the protein level, the expression of TLR4 protein was measured in brain tissue by the method of Western Blots using specific antibodies for TLR4.
T4900 10155-10217 Sentence denotes Expression of TLR4 Protein Increased in Brain Tissue after ICH
T4899 10150-10154 Sentence denotes 3.2.
T4510 9875-10148 Sentence denotes However, the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased on the 7th day after ICH (P < .05), but still maintained a higher level compared with saline control (P < .05, Figure 1).
T4509 9757-9874 Sentence denotes In the saline control group, the TLR4 mRNA slightly increased, but was not significantly different from normal group.
T4508 9689-9756 Sentence denotes The low level of TLR4 mRNA was observed in normal rat brain tissue.
T4507 9647-9688 Sentence denotes TLR4 mRNA levels were detected by Rt-PCR.
T4506 9601-9646 Sentence denotes TLR4 mRNA Increased in Brain Tissue after ICH
T4505 9596-9600 Sentence denotes 3.1.
T4015 9223-9349 Sentence denotes A super shift assay using antibodies to P65 and P50 was performed to confirm NFκB binding specificity as previously described.
T4014 9039-9222 Sentence denotes NFκB binding activity was examined in a 15 μL binding reaction mixture containing 15 μg of nuclear proteins and 35 fmol [γ-32P] labeled double-stranded NFκB consensus oligonucleotide.
T4013 8991-9038 Sentence denotes EMSA was performed as described previously [8].
T4012 8881-8990 Sentence denotes The supernatants (nuclear extract) were transferred to a clean prechilled tube and stored at −80°C until use.
T4011 8785-8880 Sentence denotes The tubes were centrifuged at maximum speed (~16,000 × g) in a micro centrifuge for 10 minutes.
T4010 8677-8784 Sentence denotes The tubes containing pellets were put on vortex for 15 seconds every 10 minutes, for a total of 40 minutes.
T4009 8556-8676 Sentence denotes Briefly, after removal of supernatant (cytoplasmic extract), the pellets were resuspended in nuclear extraction reagent.
T4008 8506-8555 Sentence denotes Nuclear proteins were isolated from brain tissue.
T4007 8462-8505 Sentence denotes Electrophoretic Mobility Shift Assay (EMSA)
T4006 8457-8461 Sentence denotes 2.6.
T3517 7677-7749 Sentence denotes Slides processed without primary antibodies served as negative controls.
T3516 7503-7676 Sentence denotes The biotinylated secondary antibody and antibody-biotin-avidin-peroxidase complexes (ABC reagent, SC-2018) were obtained from Santa Cruz Biotechnology Inc. (Santa Cruz, CA).
T3515 7435-7502 Sentence denotes The primary antibody employed was rabbit anti-TLR4 (WuHan, BA1717).
T3514 7366-7434 Sentence denotes The IHC staining for TLR4 was performed as described previously [8].
T3513 7339-7365 Sentence denotes Immunohistochemistry (IHC)
T3512 7334-7338 Sentence denotes 2.4.
T2748 7249-7332 Sentence denotes The abundance of TLR4 mRNA was expressed as the ratio of TLR4 mRNA to β-actin mRNA.
T2747 7170-7248 Sentence denotes Image Acquisition and Analysis software were used to determine band densities.
T2746 7115-7169 Sentence denotes PCR products were electrophoresed through agarose gel.
T2745 7073-7114 Sentence denotes The reaction was stopped after 31 cycles.
T2744 7024-7072 Sentence denotes 94°C 2 min, 94°C 40 s, 55°C 40 s, and 72°C 60 s.
T2743 6965-7023 Sentence denotes Reaction cycles were performed at the following condition:
T2742 6938-6964 Sentence denotes 5′-CCAGGATAGAGCCACCAAT-3′.
T2741 6902-6937 Sentence denotes 5′-GCCAACCGTGAAAAAGATG-3′; reverse:
T2740 6847-6901 Sentence denotes 5′-CAGGATGACACCATTGAAGC-3′; β-actin (701 bp): forward:
T2739 6810-6846 Sentence denotes 5′-AGCTTTGGTCAGTTGGCTCT-3′; reverse:
T1772 4499-4672 Sentence denotes Five rats in each group at each time point were sacrificed by over dose injection of Ketamine. The brains were removed and stored at minus 80°C for RT-PCR and Western Blots.
T1771 4383-4498 Sentence denotes The brains were removed, postfixed, embedded in paraffin, and cut into sections (7 μm) as described previously [8].
T1770 4225-4382 Sentence denotes Five rats in each group at each time point were sacrificed by transcardially perfusion of normal saline followed by 4% buffered Para formaldehyde (pH = 7.4).
T1769 3918-4224 Sentence denotes The experimental protocol used for animals was approved by the Animal Care and Use Committee, China Medical University. The rats were subjected to intra-cerebral injection of normal saline or autologous whole blood and were sacrificed on 6 hours, 1 day, 3 days and 7 days after the injection, respectively.
T1768 3594-3917 Sentence denotes 250 g to 300 g) were provided by Experimental Animal Center, China Medical University. The rats were assigned randomly to three groups: normal group (N, n = 10, without any treatment), normal saline control (S, n = 40, intra-cerebral injection of normal saline as control) and intra-cerebral hemorrhage group (ICH, n = 40).
T1767 3555-3593 Sentence denotes Ninety Wister rats (male, body weight:
T1766 3547-3554 Sentence denotes Animals
T1765 3542-3546 Sentence denotes 2.1.
T71 1202-1379 Sentence denotes The present study firstly suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may become a therapeutic target for ICH-induced brain damage.
T70 1089-1201 Sentence denotes The level of p-IκBα and the activity of NFκB also increased in the brain after ICH compared with saline control.
T69 851-1088 Sentence denotes Compared with saline control, the TLR4 mRNA and protein significantly increased starting at 6 hours after ICH, peaked on the 3rd day after ICH, and then decreased but still maintained at a higher level on the 7th day after ICH (P < .05).
T63 0-71 Sentence denotes Activation of TLR4-Mediated NFκB Signaling in Hemorrhagic Brain in Rats
T2248 5740-5814 Sentence denotes For the normal saline control rats, only 75 μL normal saline was injected.
T2247 5569-5739 Sentence denotes After the completion of the infusion, the needle was withdrawn quickly, cyanoacrylate glue was placed around the burr hole, and the skin incision was closed with sutures.
T2246 5456-5568 Sentence denotes Then, a 75 μL of autologous whole blood was infused at a rate of 20 μL/min with the use of a microinfusion pump.
T2245 5387-5455 Sentence denotes 0.2 mm anterior, 6.0 mm ventral, and 3.0 mm lateral to the midline).
T2244 5280-5386 Sentence denotes A blunt 26-gauge needle was inserted into the left basal ganglia under stereotactic guidance (coordinates:
T2243 5156-5279 Sentence denotes Using a sterile technique, a 1 mm burr hole was opened in the skull on the left coronal suture 3 mm lateral to the midline.
T2242 5061-5155 Sentence denotes The rats were positioned in a stereotactic frame, and the scalp was incised along the midline.
T2241 4945-5060 Sentence denotes The body (rectal) temperature was maintained at 37°C during the surgery using a feedback-controlled heating system.
T2240 4867-4944 Sentence denotes Rats were anesthetized with intra-peritoneal sodium pentobarbital (60 mg/kg).
T2239 4717-4866 Sentence denotes Since most intracerebral hemorrhages occur in the basal ganglia clinically, in the present study, rat model of ICH was induced in left basal ganglia.
T2238 4679-4716 Sentence denotes Induction of Intracerebral Hemorrhage
T2237 4674-4678 Sentence denotes 2.2.
T2738 6786-6809 Sentence denotes TLR4 (145 bp): forward:
T2737 6677-6785 Sentence denotes The PCR primer sequences were designed according to the TLR4 and β-actin gene sequences reported in GenBank.
T2736 6614-6676 Sentence denotes The house keep gene (β-actin) was used as an internal control.
T2735 6447-6613 Sentence denotes One microliter of cDNA was used to amplify the TLR4 gene fragment with 1× PCR buffer, 1.5 mM MgCl2, 200 μM of each dNTP, 200 μM of primers, and 2u Taq DNA polymerase.
T2734 6270-6446 Sentence denotes RNA was reverse-transcribed into cDNA in 20 μL reaction system using Superscript First-Strand Synthesis Kit for RT-PCR (promega Inc) under conditions described by the supplier.
T2733 6210-6269 Sentence denotes Then, the concentrations of mRNA were adjusted to 1.0 g/mL.
T2732 6066-6209 Sentence denotes The quantity of total RNA was determined on a Nanodrop (ND-1000 Spectrophotometer) by measuring optical density at A260 and A280 nm wavelength.
T2731 5868-6065 Sentence denotes Briefly, total RNA samples were isolated from peri-hemorrhage regions in left basal ganglia using Simply P Total RNA isolation Kit (BioFlux, HZ, China) according to the manufacturer's instructions.
T2730 5821-5867 Sentence denotes Detection of TLR4 mRNA by the Method of RT-PCR
T2729 5816-5820 Sentence denotes 2.3.
T850 3357-3528 Sentence denotes Our data firstly provided the knowledge about the distribution of TLR4 and the temporal profile of the activation of TLR4-mediated signaling in rat brain tissue after ICH.
T849 3197-3356 Sentence denotes In the present study, we detected the transcription of TLR4 gene and the activation of TLR4-mediated signaling in the rat brains subjected to experimental ICH.
T848 3137-3196 Sentence denotes However, little is known about TLR4 in the brain after ICH.
T847 2904-3136 Sentence denotes Accumulating evidences demonstrate that TLR4, the first mammalian TLR recognized, contributes to the neuronal death, blood brain barrier damage, brain edema, and inflammatory responses in the brain injury induced by ischemia [8, 9].
T846 2695-2903 Sentence denotes TLRs play a critical role in the induction of immunological/inflammatory responses and are implicated in several CNS diseases, such as infectious disease, autoimmune disease, and ischemic brain injury [7, 8].
T845 2556-2694 Sentence denotes Then, NFκB trans-locates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses [5, 6].
T844 2387-2555 Sentence denotes For example, combined with specific ligand, the activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB) and dissociates IκB from NF-kappa-B (NFκB).
T843 2226-2386 Sentence denotes Activation of TLRs recruits downstream signaling proteins and results in transcription of genes encoding inflammation-associated molecules and cytokines [5, 6].
T842 2136-2225 Sentence denotes TLRs are a family of transmembrane proteins and act as signal transduction molecules [4].
T841 2030-2135 Sentence denotes Nevertheless, how the inflammatory responses in ICH are triggered and regulated remains to be elucidated.
T840 1870-2029 Sentence denotes Both innate and adaptive immunological/inflammatory mechanisms have been clearly shown to participate in the progression of brain injury after ischemic stroke.
T839 1650-1869 Sentence denotes Local brain tissue deformation induces primary brain damage after ICH; more importantly, the excitotoxicity and inflammatory responses in the brain tissue induced by ICH result in further brain damage following ICH [3].
T838 1397-1649 Sentence denotes Intracerebral hemorrhage (ICH) represents 10%–15% of all strokes and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke, which is associated with high mortality and severe disability in survivors [1, 2].
T64 82-182 Sentence denotes Inflammation and immunity play a crucial role in the pathogenesis of Intracerebral hemorrhage (ICH).
T65 183-359 Sentence denotes Toll-like receptor 4- (TLR4-) mediated nuclear factor kappa-B (NFκB) signaling plays critical roles in the activation and regulation of inflammatory responses in injured brain.
T66 360-460 Sentence denotes However, the involvement of TLR4-mediated NFκB signaling in the pathogenesis of ICH remains unknown.
T67 461-635 Sentence denotes The present study was to evaluate the temporal profile of the expression of TLR4 and the activation of TLR4-mediated NFκB signaling in brain tissues of Wistar rats after ICH.
T68 636-850 Sentence denotes TLR4 mRNA and protein, the phosphorylation of inhibitors of kappa B (p-IκBα), and the activity of NFκB were examined in hemorrhagic cerebral tissue by Rt-PCR, Western blots, immunohistochemistry staining, and EMSA.
T5613 11919-12023 Sentence denotes As expected, the activity of NFκB was also increased in the same manner as that of the p-IκB (Figure 4).
T5612 11750-11918 Sentence denotes Results showed that the p-IκB increased at 6 hours after ICH (P < .05), peaked on 3 days after ICH, and maintained a high level on 7 days after ICH (P < .05, Figure 5).
T4384 9508-9582 Sentence denotes The P < .05 level of probability was used as the criteria of significance.
T4383 9416-9507 Sentence denotes The measurements were analyzed by one-way analysis of variance (ANOVA) or Student's t-test.
T4382 9377-9415 Sentence denotes All data were presented as mean ± SEM.
T4381 9356-9376 Sentence denotes Statistical Analysis
T4380 9351-9355 Sentence denotes 2.7.
T3722 8365-8455 Sentence denotes The signals were quantified by scanning densitometry and computer-assisted image analysis.
T3721 8209-8364 Sentence denotes The same membranes were probed with anti-GAPDH (glyceraldehyde-3-phosphate dehydrogenase, Biodesign, Saco, Maine) after being washed with stripping buffer.
T3720 8141-8208 Sentence denotes The signals were detected with the ECL system (Amersham Pharmacia).
T3719 7957-8140 Sentence denotes The ECL membranes were incubated with the appropriate primary antibody (WuHan, BA1717) followed by incubation with peroxidase-conjugated secondary antibodies (Golden Bridge, PV-6001).
T3718 7770-7956 Sentence denotes Cellular proteins were prepared from ICH cerebral hemispheres, electrophoresed with SDS-polyacrylamide gel and transferred onto Hybond ECL membranes (Amersham Pharmacia, Piscataway, NJ).
T3717 7756-7769 Sentence denotes Western Blots
T3716 7751-7755 Sentence denotes 2.5.
T1 0-71 Sentence denotes Activation of TLR4-Mediated NFκB Signaling in Hemorrhagic Brain in Rats
T2 73-81 Sentence denotes Abstract
T3 82-182 Sentence denotes Inflammation and immunity play a crucial role in the pathogenesis of Intracerebral hemorrhage (ICH).
T4 183-359 Sentence denotes Toll-like receptor 4- (TLR4-) mediated nuclear factor kappa-B (NFκB) signaling plays critical roles in the activation and regulation of inflammatory responses in injured brain.
T5 360-460 Sentence denotes However, the involvement of TLR4-mediated NFκB signaling in the pathogenesis of ICH remains unknown.
T6 461-635 Sentence denotes The present study was to evaluate the temporal profile of the expression of TLR4 and the activation of TLR4-mediated NFκB signaling in brain tissues of Wistar rats after ICH.
T7 636-850 Sentence denotes TLR4 mRNA and protein, the phosphorylation of inhibitors of kappa B (p-IκBα), and the activity of NFκB were examined in hemorrhagic cerebral tissue by Rt-PCR, Western blots, immunohistochemistry staining, and EMSA.
T8 851-1088 Sentence denotes Compared with saline control, the TLR4 mRNA and protein significantly increased starting at 6 hours after ICH, peaked on the 3rd day after ICH, and then decreased but still maintained at a higher level on the 7th day after ICH (P < .05).
T9 1089-1201 Sentence denotes The level of p-IκBα and the activity of NFκB also increased in the brain after ICH compared with saline control.
T10 1202-1379 Sentence denotes The present study firstly suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may become a therapeutic target for ICH-induced brain damage.
T11 1381-1383 Sentence denotes 1.
T12 1384-1396 Sentence denotes Introduction
T13 1397-1649 Sentence denotes Intracerebral hemorrhage (ICH) represents 10%–15% of all strokes and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke, which is associated with high mortality and severe disability in survivors [1, 2].
T14 1650-1869 Sentence denotes Local brain tissue deformation induces primary brain damage after ICH; more importantly, the excitotoxicity and inflammatory responses in the brain tissue induced by ICH result in further brain damage following ICH [3].
T15 1870-2029 Sentence denotes Both innate and adaptive immunological/inflammatory mechanisms have been clearly shown to participate in the progression of brain injury after ischemic stroke.
T16 2030-2135 Sentence denotes Nevertheless, how the inflammatory responses in ICH are triggered and regulated remains to be elucidated.
T17 2136-2225 Sentence denotes TLRs are a family of transmembrane proteins and act as signal transduction molecules [4].
T18 2226-2386 Sentence denotes Activation of TLRs recruits downstream signaling proteins and results in transcription of genes encoding inflammation-associated molecules and cytokines [5, 6].
T19 2387-2555 Sentence denotes For example, combined with specific ligand, the activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB) and dissociates IκB from NF-kappa-B (NFκB).
T20 2556-2694 Sentence denotes Then, NFκB trans-locates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses [5, 6].
T21 2695-2903 Sentence denotes TLRs play a critical role in the induction of immunological/inflammatory responses and are implicated in several CNS diseases, such as infectious disease, autoimmune disease, and ischemic brain injury [7, 8].
T22 2904-3136 Sentence denotes Accumulating evidences demonstrate that TLR4, the first mammalian TLR recognized, contributes to the neuronal death, blood brain barrier damage, brain edema, and inflammatory responses in the brain injury induced by ischemia [8, 9].
T23 3137-3196 Sentence denotes However, little is known about TLR4 in the brain after ICH.
T24 3197-3356 Sentence denotes In the present study, we detected the transcription of TLR4 gene and the activation of TLR4-mediated signaling in the rat brains subjected to experimental ICH.
T25 3357-3528 Sentence denotes Our data firstly provided the knowledge about the distribution of TLR4 and the temporal profile of the activation of TLR4-mediated signaling in rat brain tissue after ICH.
T26 3530-3532 Sentence denotes 2.
T27 3533-3540 Sentence denotes Methods
T28 3542-3546 Sentence denotes 2.1.
T29 3547-3554 Sentence denotes Animals
T30 3555-3593 Sentence denotes Ninety Wister rats (male, body weight:
T31 3594-3680 Sentence denotes 250 g to 300 g) were provided by Experimental Animal Center, China Medical University.
T32 3681-3917 Sentence denotes The rats were assigned randomly to three groups: normal group (N, n = 10, without any treatment), normal saline control (S, n = 40, intra-cerebral injection of normal saline as control) and intra-cerebral hemorrhage group (ICH, n = 40).
T33 3918-4037 Sentence denotes The experimental protocol used for animals was approved by the Animal Care and Use Committee, China Medical University.
T34 4038-4224 Sentence denotes The rats were subjected to intra-cerebral injection of normal saline or autologous whole blood and were sacrificed on 6 hours, 1 day, 3 days and 7 days after the injection, respectively.
T35 4225-4382 Sentence denotes Five rats in each group at each time point were sacrificed by transcardially perfusion of normal saline followed by 4% buffered Para formaldehyde (pH = 7.4).
T36 4383-4498 Sentence denotes The brains were removed, postfixed, embedded in paraffin, and cut into sections (7 μm) as described previously [8].
T37 4499-4593 Sentence denotes Five rats in each group at each time point were sacrificed by over dose injection of Ketamine.
T38 4594-4672 Sentence denotes The brains were removed and stored at minus 80°C for RT-PCR and Western Blots.
T39 4674-4678 Sentence denotes 2.2.
T40 4679-4716 Sentence denotes Induction of Intracerebral Hemorrhage
T41 4717-4866 Sentence denotes Since most intracerebral hemorrhages occur in the basal ganglia clinically, in the present study, rat model of ICH was induced in left basal ganglia.
T42 4867-4944 Sentence denotes Rats were anesthetized with intra-peritoneal sodium pentobarbital (60 mg/kg).
T43 4945-5060 Sentence denotes The body (rectal) temperature was maintained at 37°C during the surgery using a feedback-controlled heating system.
T44 5061-5155 Sentence denotes The rats were positioned in a stereotactic frame, and the scalp was incised along the midline.
T45 5156-5279 Sentence denotes Using a sterile technique, a 1 mm burr hole was opened in the skull on the left coronal suture 3 mm lateral to the midline.
T46 5280-5386 Sentence denotes A blunt 26-gauge needle was inserted into the left basal ganglia under stereotactic guidance (coordinates:
T47 5387-5455 Sentence denotes 0.2 mm anterior, 6.0 mm ventral, and 3.0 mm lateral to the midline).
T48 5456-5568 Sentence denotes Then, a 75 μL of autologous whole blood was infused at a rate of 20 μL/min with the use of a microinfusion pump.
T49 5569-5739 Sentence denotes After the completion of the infusion, the needle was withdrawn quickly, cyanoacrylate glue was placed around the burr hole, and the skin incision was closed with sutures.
T50 5740-5814 Sentence denotes For the normal saline control rats, only 75 μL normal saline was injected.
T51 5816-5820 Sentence denotes 2.3.
T52 5821-5867 Sentence denotes Detection of TLR4 mRNA by the Method of RT-PCR
T53 5868-6065 Sentence denotes Briefly, total RNA samples were isolated from peri-hemorrhage regions in left basal ganglia using Simply P Total RNA isolation Kit (BioFlux, HZ, China) according to the manufacturer's instructions.
T54 6066-6209 Sentence denotes The quantity of total RNA was determined on a Nanodrop (ND-1000 Spectrophotometer) by measuring optical density at A260 and A280 nm wavelength.
T55 6210-6269 Sentence denotes Then, the concentrations of mRNA were adjusted to 1.0 g/mL.
T56 6270-6446 Sentence denotes RNA was reverse-transcribed into cDNA in 20 μL reaction system using Superscript First-Strand Synthesis Kit for RT-PCR (promega Inc) under conditions described by the supplier.
T57 6447-6613 Sentence denotes One microliter of cDNA was used to amplify the TLR4 gene fragment with 1× PCR buffer, 1.5 mM MgCl2, 200 μM of each dNTP, 200 μM of primers, and 2u Taq DNA polymerase.
T58 6614-6676 Sentence denotes The house keep gene (β-actin) was used as an internal control.
T59 6677-6785 Sentence denotes The PCR primer sequences were designed according to the TLR4 and β-actin gene sequences reported in GenBank.
T60 6786-6809 Sentence denotes TLR4 (145 bp): forward:
T61 6810-6846 Sentence denotes 5′-AGCTTTGGTCAGTTGGCTCT-3′; reverse:
T62 6847-6901 Sentence denotes 5′-CAGGATGACACCATTGAAGC-3′; β-actin (701 bp): forward:
T63 6902-6937 Sentence denotes 5′-GCCAACCGTGAAAAAGATG-3′; reverse:
T64 6938-6964 Sentence denotes 5′-CCAGGATAGAGCCACCAAT-3′.
T65 6965-7023 Sentence denotes Reaction cycles were performed at the following condition:
T66 7024-7072 Sentence denotes 94°C 2 min, 94°C 40 s, 55°C 40 s, and 72°C 60 s.
T67 7073-7114 Sentence denotes The reaction was stopped after 31 cycles.
T68 7115-7169 Sentence denotes PCR products were electrophoresed through agarose gel.
T69 7170-7248 Sentence denotes Image Acquisition and Analysis software were used to determine band densities.
T70 7249-7332 Sentence denotes The abundance of TLR4 mRNA was expressed as the ratio of TLR4 mRNA to β-actin mRNA.
T71 7334-7338 Sentence denotes 2.4.
T72 7339-7365 Sentence denotes Immunohistochemistry (IHC)
T73 7366-7434 Sentence denotes The IHC staining for TLR4 was performed as described previously [8].
T74 7435-7502 Sentence denotes The primary antibody employed was rabbit anti-TLR4 (WuHan, BA1717).
T75 7503-7676 Sentence denotes The biotinylated secondary antibody and antibody-biotin-avidin-peroxidase complexes (ABC reagent, SC-2018) were obtained from Santa Cruz Biotechnology Inc. (Santa Cruz, CA).
T76 7677-7749 Sentence denotes Slides processed without primary antibodies served as negative controls.
T77 7751-7755 Sentence denotes 2.5.
T78 7756-7769 Sentence denotes Western Blots
T79 7770-7956 Sentence denotes Cellular proteins were prepared from ICH cerebral hemispheres, electrophoresed with SDS-polyacrylamide gel and transferred onto Hybond ECL membranes (Amersham Pharmacia, Piscataway, NJ).
T80 7957-8140 Sentence denotes The ECL membranes were incubated with the appropriate primary antibody (WuHan, BA1717) followed by incubation with peroxidase-conjugated secondary antibodies (Golden Bridge, PV-6001).
T81 8141-8208 Sentence denotes The signals were detected with the ECL system (Amersham Pharmacia).
T82 8209-8364 Sentence denotes The same membranes were probed with anti-GAPDH (glyceraldehyde-3-phosphate dehydrogenase, Biodesign, Saco, Maine) after being washed with stripping buffer.
T83 8365-8455 Sentence denotes The signals were quantified by scanning densitometry and computer-assisted image analysis.
T84 8457-8461 Sentence denotes 2.6.
T85 8462-8505 Sentence denotes Electrophoretic Mobility Shift Assay (EMSA)
T86 8506-8555 Sentence denotes Nuclear proteins were isolated from brain tissue.
T87 8556-8676 Sentence denotes Briefly, after removal of supernatant (cytoplasmic extract), the pellets were resuspended in nuclear extraction reagent.
T88 8677-8784 Sentence denotes The tubes containing pellets were put on vortex for 15 seconds every 10 minutes, for a total of 40 minutes.
T89 8785-8880 Sentence denotes The tubes were centrifuged at maximum speed (~16,000 × g) in a micro centrifuge for 10 minutes.
T90 8881-8990 Sentence denotes The supernatants (nuclear extract) were transferred to a clean prechilled tube and stored at −80°C until use.
T91 8991-9038 Sentence denotes EMSA was performed as described previously [8].
T92 9039-9222 Sentence denotes NFκB binding activity was examined in a 15 μL binding reaction mixture containing 15 μg of nuclear proteins and 35 fmol [γ-32P] labeled double-stranded NFκB consensus oligonucleotide.
T93 9223-9349 Sentence denotes A super shift assay using antibodies to P65 and P50 was performed to confirm NFκB binding specificity as previously described.
T94 9351-9355 Sentence denotes 2.7.
T95 9356-9376 Sentence denotes Statistical Analysis
T96 9377-9415 Sentence denotes All data were presented as mean ± SEM.
T97 9416-9507 Sentence denotes The measurements were analyzed by one-way analysis of variance (ANOVA) or Student's t-test.
T98 9508-9582 Sentence denotes The P < .05 level of probability was used as the criteria of significance.
T99 9584-9586 Sentence denotes 3.
T100 9587-9594 Sentence denotes Results
T101 9596-9600 Sentence denotes 3.1.
T102 9601-9646 Sentence denotes TLR4 mRNA Increased in Brain Tissue after ICH
T103 9647-9688 Sentence denotes TLR4 mRNA levels were detected by Rt-PCR.
T104 9689-9756 Sentence denotes The low level of TLR4 mRNA was observed in normal rat brain tissue.
T105 9757-9874 Sentence denotes In the saline control group, the TLR4 mRNA slightly increased, but was not significantly different from normal group.
T106 9875-10148 Sentence denotes However, the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased on the 7th day after ICH (P < .05), but still maintained a higher level compared with saline control (P < .05, Figure 1).
T107 10150-10154 Sentence denotes 3.2.
T108 10155-10217 Sentence denotes Expression of TLR4 Protein Increased in Brain Tissue after ICH
T109 10218-10400 Sentence denotes To investigate the increased TLR4 at the protein level, the expression of TLR4 protein was measured in brain tissue by the method of Western Blots using specific antibodies for TLR4.
T110 10401-10496 Sentence denotes Our results showed that a low level of TLR4 protein was detectable in the saline control group.
T111 10497-10721 Sentence denotes The expression of TLR4 significantly increased starting from 6 hours after ICH (P < .05), peaked on the 3rd day after ICH, and then decreased but still maintained at a high level on the 7th day after ICH (P < .05, Figure 2).
T112 10722-10823 Sentence denotes This observation of TLR4 protein was consistent with the temporal profile of the TLR4 mRNA after ICH.
T113 10825-10829 Sentence denotes 3.3.
T114 10830-10876 Sentence denotes Distribution of TLR4 in Brain Subjected to ICH
T115 10877-10974 Sentence denotes To explore the distribution of TLR4 protein, the TLR4 was detected by immunohistochemistry (IHC).
T116 10975-11081 Sentence denotes Results showed that TLR4 immunoreactivity was not detectable in brain tissue from normal and sham control.
T117 11082-11255 Sentence denotes However, immunoreactivity for TLR4 was consistently demonstrated in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts (Figure 3).
T118 11257-11261 Sentence denotes 3.4.
T119 11262-11310 Sentence denotes Activation of TLR4-Mediated NF-Kappa-B Signaling
T120 11311-11434 Sentence denotes Activation of TLR4 induces the phosphorylation of inhibitor of kappa-B (IκB), which dissociates IκB with NF-kappa-B (NFκB).
T121 11435-11565 Sentence denotes Then, NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses.
T122 11566-11749 Sentence denotes To detectd the activation of TLR4-mediated NFκB signaling, the phosphorylation of inhibitor of kappa-B (p-IκB) and activity of NFκB were measured by methods of Western Blots and EMSA.
T123 11750-11918 Sentence denotes Results showed that the p-IκB increased at 6 hours after ICH (P < .05), peaked on 3 days after ICH, and maintained a high level on 7 days after ICH (P < .05, Figure 5).
T124 11919-12023 Sentence denotes As expected, the activity of NFκB was also increased in the same manner as that of the p-IκB (Figure 4).
T125 12025-12027 Sentence denotes 4.
T126 12028-12038 Sentence denotes Discussion
T127 12039-12213 Sentence denotes Intra-cerebral hemorrhage (ICH) represents 10–15% of all strokes, and occurs with increasing frequency as a complication of the thrombolytic treatment of ischemic stroke [1].
T128 12214-12274 Sentence denotes The mortality of ICH is higher than that of ischemic stroke.
T129 12275-12325 Sentence denotes Only 31% are functionally independent at 3 months.
T130 12326-12377 Sentence denotes Only 38% of the patients survive the 1st year [10].
T131 12378-12497 Sentence denotes Unfortunately, the method for treatment of this disease and protection of the brain tissue after ICH are not effective.
T132 12498-12591 Sentence denotes Mass effect, ischemia, and toxicity of blood components after ICH induce brain tissue damage.
T133 12592-12701 Sentence denotes In addition, there is increasing evidence that inflammatory processes are involved in cerebrovascular events.
T134 12702-12895 Sentence denotes After ICH, inflammatory mediators from the blood might enter to the brain and induce an inflammatory reaction and the brain cells itself are also capable of producing many of these agents [11].
T135 12896-13025 Sentence denotes The inflammatory responses are responsible for the ICH induced brain injury, which could provide new therapeutic targets for ICH.
T136 13026-13207 Sentence denotes Various constituents of the inflammatory response, including adhesion molecules, cytokines, leukocytes, immunoglobulins, and complement, may be important in the pathogenesis of ICH.
T137 13208-13316 Sentence denotes However, how the inflammatory responses is activated and regulated in the brain tissue after ICH is unclear.
T138 13317-13586 Sentence denotes Transcription factor nuclear factor-kappa-B (NFκB) is an important nuclear transcription factor, which initiates transcription of genes associated with immune responses and inflammation [12, 13] and also plays a key role in regulating inflammation in brain pathologies.
T139 13587-13673 Sentence denotes It has been reported that NFκB increased in the region of perihematoma after ICH [14].
T140 13674-13835 Sentence denotes NFκB activation occurs within minutes and persists for at least a week in response to ICH, which is associated with the expression of selected target genes [15].
T141 13836-13966 Sentence denotes Activation of NFκB initiates inflammatory responses and contributes to the pathobiology of perilesional cell death after ICH [16].
T142 13967-14154 Sentence denotes Inhibition of NFκB activity has been shown to have a therapeutic effect on experimental ICH, such as reduce inflammation, behavioral dysfunction, and neuronal damage produced by ICH [17].
T143 14155-14288 Sentence denotes The knowledge about how NFκB is activated in the brain subjected to ICH is critical for seeking a new neuroprotective method for ICH.
T144 14289-14440 Sentence denotes Toll-like receptors (TLRs) are a family of signal transduction molecules and play a critical role in the induction of innate and adaptive immunity [4].
T145 14441-14522 Sentence denotes TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13].
T146 14523-14732 Sentence denotes TLR4, the first mammalian TLR recognized, has been reported to be involved in several central nervous (CNS) system diseases, such as inflammatory or autoimmune CNS diseases and cerebral ischemic injury [7, 8].
T147 14733-15055 Sentence denotes Although previous reports indicated that the activation of NFκB was attributed to the oxidative stress or glutamate receptor activation induced by red blood cells and/or plasma constituents [17], very few studies have been directed to investigate the role and the relationship between TLR4-mediated NFκB signaling and ICH.
T148 15056-15166 Sentence denotes In the present study, we established the rat model of experimental ICH and detected the TLR4 mRNA and protein.
T149 15167-15301 Sentence denotes Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH significantly elevated in brain tissue.
T150 15302-15417 Sentence denotes These changes started as early as 6 hours after the ICH insult and maintained at a high level for 7 days afterward.
T151 15418-15596 Sentence denotes The TLR4 protein, detected by immunohistochemistry, was consistently distributed in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts.
T152 15597-15745 Sentence denotes These data indicated that increased expression of TLR4 may be related to the triggering of the inflammatory responses in the brain tissue after ICH.
T153 15746-15894 Sentence denotes Recent studies demonstrated that ICH initiates inflammatory responses, which are associated with secondary growth of hemorrhage and cell death [18].
T154 15895-16011 Sentence denotes It is now believed that TLR4-mediated-NFκB pathway activates and regulates immunological and inflammatory responses.
T155 16012-16266 Sentence denotes To investigate the mechanisms underlying the increased inflammatory responses in the brain after ICH, in the present study, we evaluated the activation of TLR4-mediated NFκB signaling by detecting the p-IκB and the activity of NFκB in hemorrhagic brains.
T156 16267-16359 Sentence denotes NFκB is an important transcription factor downstream in the TLR4-mediated signaling pathway.
T157 16360-16575 Sentence denotes Activation of TLR4 stimulates IκBα phosphorylation and degradation, resulting in nuclear translocation of NFκB, which initiates transcription of genes associated with innate immune responses and inflammation [5, 6].
T158 16576-16710 Sentence denotes We observed that the levels of phosphorylation of IκB and the activity of NFκB were significantly increased in brain tissue after ICH.
T159 16711-16832 Sentence denotes The temporal profile of the expression of p-IκB and the activation of NFκB was similar to that of the expression of TLR4.
T160 16833-17040 Sentence denotes Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway, which is consistent with previous reports that activation of NFκB is regulated through the TLR4-mediated signaling pathway.
T161 17041-17353 Sentence denotes TLR4 plays an important role in the recognition of microbial components [19, 20] and can also recognize endogenous molecules such as the degradation products of macromolecules, products of proteolytic cascades, intracellular components of ruptured cells, and products of genes that are activated by inflammation.
T162 17354-17550 Sentence denotes For instance, HSP70, HSP32, HSP27, and enzymes involved in oxidative stress are found to be upregulated in the brain after ICH, which may be produced by injured neuronal cells or blood cells [21].
T163 17551-17798 Sentence denotes It may be speculated that these molecules produced in damaged brain or came from blood cells and constituents of plasma server as endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling, and initiate the inflammatory responses in IHC brain.
T164 17799-17946 Sentence denotes However, the specific endogenous ligands for TLR4 in hemorrhagic brain have not been determined and need to be identified through further research.
T165 17947-18287 Sentence denotes In conclusion, the present study demonstrated the temporal profile of the activation of TLR4-mediated NFκB signaling in brain tissue in a rat model of experimental ICH, which suggests that TLR4-mediated NFκB signaling participates in the pathogenesis of ICH, which may be a therapeutic target for the prevention of ICH-induced brain damage.
T166 18289-18360 Sentence denotes Figure 1 The temporal changes of TLR4 mRNA in brain tissue after ICH.
T167 18361-18402 Sentence denotes TLR4 mRNA levels were detected by Rt-PCR.
T168 18403-18486 Sentence denotes The abundance of TLR4 mRNA was expressed as the ratio of TLR4 mRNA to β-actin mRNA.
T169 18487-18576 Sentence denotes As shown in Figure 1, the low level of TLR4 mRNA was observed in normal rat brain tissue.
T170 18577-18692 Sentence denotes In the saline control group, the TLR4 mRNA slightly increased but was no significantly different from normal group.
T171 18693-19035 Sentence denotes However, the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH (P <.05), peaked on 3 days after ICH (P < .05), and then decreased on 7 days after ICH, but still maintained at a higher level compared with saline control (P < .05). #: compared with saline control, P < .05; *: compared with 6 hours after ICH, P < .05.
T172 19036-19110 Sentence denotes Figure 2 The temporal changes of TLR4 protein in brain tissue after ICH.
T173 19111-19235 Sentence denotes The expression of TLR4 protein was measured in brain tissue by the method of Western Blots using specific antibody for TLR4.
T174 19236-19378 Sentence denotes The signals were quantified by scanning densitometry and computer-assisted image analysis and expressed as the ratio of TLR4 protein to GAPDH.
T175 19379-19472 Sentence denotes The results showed that low level of TLR4 protein was detectable in the saline control group.
T176 19473-19764 Sentence denotes The expression of TLR4 significantly increased starting from 6 hours after ICH (P < .05), peaked on 3 days after ICH, and then decreased but still maintained at a high level on 7 days after ICH (P < .05). #: compared with saline control, P < .05; *: compared with 6 hours after ICH, P < .05.
T177 19765-19834 Sentence denotes Figure 3 The distribution of TLR4 protein in brain tissue after ICH.
T178 19835-19906 Sentence denotes Immunohistochemistry staining for TLR4 was performed on brain sections.
T179 19907-19964 Sentence denotes Figure 3(a) showed the brain section of the model of ICH.
T180 19965-20124 Sentence denotes Results from the immunohistochemistry staining showed that TLR4 immunoreactivity was not detectable in brain tissue from normal and sham control (Figure 3(b)).
T181 20125-20311 Sentence denotes However, immunoreactivity for TLR4 was consistently demonstrated in peri-hemorrhage areas, the hippocampus, cortex, thalamic nuclei, and some white matter tracts (Figures 3(c) and 3(d)).
T182 20312-20410 Sentence denotes Figure 5 The increased phosphorylation of inhibitor of kappa-B α (p-I κ B α)in brain after ICH.
T183 20411-20541 Sentence denotes The expression of p-IκB in brain tissue was measured by the method of Western Blots using specific antibodies for p-IκBα and IκBα.
T184 20542-20677 Sentence denotes The signals were quantified by scanning densitometry and computer-assisted image analysis and expressed as the ratio of p-IκBα to IκBα.
T185 20678-20881 Sentence denotes The results showed that the p-IκB increased at 6 hours after ICH (P < .05), peaked on 3 days after ICH and maintained a high level on 7 days after ICH (P < .05). #: compared with saline control, P < .05.
T186 20882-20951 Sentence denotes Figure 4 NFκB activation in the brain in the rats subjected to ICH.
T187 20952-21067 Sentence denotes Nuclear proteins were isolated from brain tissues and the NFκB binding activity was examined by the method of EMSA.
T188 21068-21158 Sentence denotes The signals were quantified by scanning densitometry and computer-assisted image analysis.
T189 21159-21279 Sentence denotes The results were expressed as the ratio of the integrated density volume (IDV) of NFκB to the average IDV of background.
T190 21280-21495 Sentence denotes The results showed that the activity of NFκB increased at 6 hours after ICH (P < .05), peaked on 3 days after ICH and maintained a high level on 7 days after ICH (P < .05). #: compared with saline control, P < .05).

ICD10

Id Subject Object Predicate Lexical cue
T6395 14617-14624 http://purl.bioontology.org/ontology/ICD10/R45.0 denotes nervous
T6394 14718-14724 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T6393 12965-12971 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T886 3102-3108 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T885 2889-2895 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury
T884 2000-2006 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury

simple1

Id Subject Object Predicate Lexical cue
T143 14-18 Protein denotes TLR4
T6523 14523-14527 Protein denotes TLR4
T4542 9888-9892 Protein denotes TLR4
T4541 9790-9794 Protein denotes TLR4
T4540 9706-9710 Protein denotes TLR4
T4539 9647-9651 Protein denotes TLR4
T4538 9601-9605 Protein denotes TLR4
T4957 10803-10807 Protein denotes TLR4
T4956 10742-10746 Protein denotes TLR4
T4955 10515-10519 Protein denotes TLR4
T4954 10440-10444 Protein denotes TLR4
T4953 10395-10399 Protein denotes TLR4
T4952 10292-10296 Protein denotes TLR4
T4951 10247-10251 Protein denotes TLR4
T4950 10169-10173 Protein denotes TLR4
T4033 9271-9274 Protein denotes P50
T4032 9263-9266 Protein denotes P65
T2815 7319-7326 Protein denotes β-actin
T2814 7306-7310 Protein denotes TLR4
T2813 7266-7270 Protein denotes TLR4
T2812 6875-6882 Protein denotes β-actin
T2811 6786-6790 Protein denotes TLR4
T2810 6742-6749 Protein denotes β-actin
T2809 6733-6737 Protein denotes TLR4
T2808 6635-6642 Protein denotes β-actin
T2807 6614-6633 Protein denotes The house keep gene
T2806 6594-6612 Protein denotes Taq DNA polymerase
T2805 6494-6498 Protein denotes TLR4
T2804 5834-5838 Protein denotes TLR4
T930 3474-3478 Protein denotes TLR4
T929 3423-3427 Protein denotes TLR4
T928 3284-3288 Protein denotes TLR4
T927 3252-3256 Protein denotes TLR4
T926 3168-3172 Protein denotes TLR4
T925 2944-2948 Protein denotes TLR4
T924 2449-2453 Protein denotes TLR4
T154 1242-1246 Protein denotes TLR4
T153 1104-1108 Protein denotes IκBα
T152 885-889 Protein denotes TLR4
T151 707-711 Protein denotes IκBα
T150 682-703 Protein denotes inhibitors of kappa B
T149 636-640 Protein denotes TLR4
T148 564-568 Protein denotes TLR4
T147 537-541 Protein denotes TLR4
T146 388-392 Protein denotes TLR4
T145 206-210 Protein denotes TLR4
T144 183-203 Protein denotes Toll-like receptor 4
T6546 18136-18140 Protein denotes TLR4
T6545 18035-18039 Protein denotes TLR4
T6544 17844-17848 Protein denotes TLR4
T6543 17715-17719 Protein denotes TLR4
T6542 17692-17696 Protein denotes TLR4
T6541 17382-17387 Protein denotes HSP27
T6540 17375-17380 Protein denotes HSP32
T6539 17368-17373 Protein denotes HSP70
T6538 17041-17045 Protein denotes TLR4
T6537 17008-17012 Protein denotes TLR4
T6536 16888-16892 Protein denotes TLR4
T6535 16827-16831 Protein denotes TLR4
T6534 16390-16394 Protein denotes IκBα
T6533 16374-16378 Protein denotes TLR4
T6532 16327-16331 Protein denotes TLR4
T6531 16167-16171 Protein denotes TLR4
T6530 15919-15923 Protein denotes TLR4
T6529 15647-15651 Protein denotes TLR4
T6528 15422-15426 Protein denotes TLR4
T6527 15239-15243 Protein denotes TLR4
T6526 15205-15209 Protein denotes TLR4
T6525 15144-15148 Protein denotes TLR4
T6524 15018-15022 Protein denotes TLR4
T5664 11595-11599 Protein denotes TLR4
T5663 11325-11329 Protein denotes TLR4
T5662 11276-11280 Protein denotes TLR4
T5390 11112-11116 Protein denotes TLR4
T5389 10995-10999 Protein denotes TLR4
T5388 10926-10930 Protein denotes TLR4
T5387 10908-10912 Protein denotes TLR4
T5386 10846-10850 Protein denotes TLR4
T3743 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3742 8250-8255 Protein denotes GAPDH
T3540 7559-7565 Protein denotes avidin
T3539 7387-7391 Protein denotes TLR4

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T721 14-18 Protein denotes TLR4
T8932 15633-15643 Gene_expression denotes expression
T8931 15623-15632 Positive_regulation denotes increased
T8930 15487-15498 Localization denotes distributed
T8929 15436-15444 Gene_expression denotes detected
T8928 15188-15201 Transcription denotes transcription
T8927 15225-15235 Gene_expression denotes expression
T8926 15276-15284 Positive_regulation denotes elevated
T8925 15131-15139 Transcription denotes detected
T8924 14553-14563 Binding denotes recognized
T8923 18136-18140 Protein denotes TLR4
T8922 18035-18039 Protein denotes TLR4
T8921 17844-17848 Protein denotes TLR4
T8920 17715-17719 Protein denotes TLR4
T8919 17692-17696 Protein denotes TLR4
T8918 17382-17387 Protein denotes HSP27
T8917 17375-17380 Protein denotes HSP32
T8916 17368-17373 Protein denotes HSP70
T8915 17041-17045 Protein denotes TLR4
T8914 17008-17012 Protein denotes TLR4
T8913 16888-16892 Protein denotes TLR4
T8912 16827-16831 Protein denotes TLR4
T8911 16390-16394 Protein denotes IκBα
T8910 16374-16378 Protein denotes TLR4
T8909 16327-16331 Protein denotes TLR4
T8908 16167-16171 Protein denotes TLR4
T8907 15919-15923 Protein denotes TLR4
T8906 15647-15651 Protein denotes TLR4
T8905 15422-15426 Protein denotes TLR4
T8904 15239-15243 Protein denotes TLR4
T8903 15205-15209 Protein denotes TLR4
T8902 15144-15148 Protein denotes TLR4
T8901 15018-15022 Protein denotes TLR4
T8900 14523-14527 Protein denotes TLR4
T6007 11311-11321 Positive_regulation denotes Activation
T6006 11595-11599 Protein denotes TLR4
T6005 11325-11329 Protein denotes TLR4
T6004 11276-11280 Protein denotes TLR4
T5575 11091-11107 Binding denotes immunoreactivity
T5574 10935-10943 Gene_expression denotes detected
T5573 11112-11116 Protein denotes TLR4
T5572 10995-10999 Protein denotes TLR4
T5571 10926-10930 Protein denotes TLR4
T5570 10908-10912 Protein denotes TLR4
T5569 10846-10850 Protein denotes TLR4
T5306 10501-10511 Gene_expression denotes expression
T5305 10629-10638 Negative_regulation denotes decreased
T5304 10534-10543 Positive_regulation denotes increased
T5303 10237-10246 Positive_regulation denotes increased
T5302 10278-10288 Gene_expression denotes expression
T5301 10155-10165 Gene_expression denotes Expression
T5300 10182-10191 Positive_regulation denotes Increased
T5299 10803-10807 Protein denotes TLR4
T5298 10742-10746 Protein denotes TLR4
T5297 10515-10519 Protein denotes TLR4
T5296 10440-10444 Protein denotes TLR4
T5295 10395-10399 Protein denotes TLR4
T5294 10292-10296 Protein denotes TLR4
T5293 10247-10251 Protein denotes TLR4
T5292 10169-10173 Protein denotes TLR4
T4828 10017-10026 Negative_regulation denotes decreased
T4827 9922-9931 Positive_regulation denotes increased
T4826 9809-9818 Positive_regulation denotes increased
T4825 9697-9702 Transcription denotes level
T4824 9657-9663 Transcription denotes levels
T4823 9611-9620 Positive_regulation denotes Increased
T4822 9888-9892 Protein denotes TLR4
T4821 9790-9794 Protein denotes TLR4
T4820 9706-9710 Protein denotes TLR4
T4819 9647-9651 Protein denotes TLR4
T4818 9601-9605 Protein denotes TLR4
T4360 9271-9274 Protein denotes P50
T4359 9263-9266 Protein denotes P65
T3972 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3971 8250-8255 Protein denotes GAPDH
T3690 7559-7565 Protein denotes avidin
T3689 7387-7391 Protein denotes TLR4
T3473 7253-7262 Transcription denotes abundance
T3472 7319-7326 Protein denotes β-actin
T3471 7306-7310 Protein denotes TLR4
T3470 7266-7270 Protein denotes TLR4
T3469 6875-6882 Protein denotes β-actin
T3468 6786-6790 Protein denotes TLR4
T3467 6742-6749 Protein denotes β-actin
T3466 6733-6737 Protein denotes TLR4
T3465 6635-6642 Protein denotes β-actin
T3464 6614-6633 Protein denotes The house keep gene
T3463 6594-6612 Protein denotes Taq DNA polymerase
T3462 6494-6498 Protein denotes TLR4
T3461 5834-5838 Protein denotes TLR4
T1722 3235-3248 Transcription denotes transcription
T1721 2974-2984 Binding denotes recognized
T1720 2454-2461 Positive_regulation denotes induces
T1719 2435-2445 Positive_regulation denotes activation
T1718 3474-3478 Protein denotes TLR4
T1717 3423-3427 Protein denotes TLR4
T1716 3284-3288 Protein denotes TLR4
T1715 3252-3256 Protein denotes TLR4
T1714 3168-3172 Protein denotes TLR4
T1713 2944-2948 Protein denotes TLR4
T1712 2449-2453 Protein denotes TLR4
T738 1139-1148 Positive_regulation denotes increased
T737 921-930 Positive_regulation denotes increased
T736 1004-1013 Negative_regulation denotes decreased
T735 1024-1034 Positive_regulation denotes maintained
T734 663-678 Phosphorylation denotes phosphorylation
T733 523-533 Gene_expression denotes expression
T732 1242-1246 Protein denotes TLR4
T731 1104-1108 Protein denotes IκBα
T730 885-889 Protein denotes TLR4
T729 707-711 Protein denotes IκBα
T728 682-703 Protein denotes inhibitors of kappa B
T727 636-640 Protein denotes TLR4
T726 564-568 Protein denotes TLR4
T725 537-541 Protein denotes TLR4
T724 388-392 Protein denotes TLR4
T723 206-210 Protein denotes TLR4
T722 183-203 Protein denotes Toll-like receptor 4
T8939 17446-17457 Positive_regulation denotes upregulated
T8938 17135-17144 Binding denotes recognize
T8937 16813-16823 Gene_expression denotes expression
T8936 16415-16426 Protein_catabolism denotes degradation
T8935 16395-16410 Phosphorylation denotes phosphorylation
T8934 16379-16389 Positive_regulation denotes stimulates
T8933 16360-16370 Positive_regulation denotes Activation
R509 T725 T733 themeOf TLR4,expression
R510 T727 T734 themeOf TLR4,phosphorylation
R511 T728 T734 themeOf inhibitors of kappa B,phosphorylation
R512 T730 T737 themeOf TLR4,increased
R513 T730 T736 themeOf TLR4,decreased
R514 T730 T735 themeOf TLR4,maintained
R515 T731 T738 themeOf IκBα,increased
R1310 T1712 T1719 themeOf TLR4,activation
R1311 T1713 T1721 themeOf TLR4,recognized
R1312 T1715 T1722 themeOf TLR4,transcription
R1313 T1719 T1720 themeOf activation,induces
R2753 T3470 T3473 themeOf TLR4,abundance
R3763 T4818 T4823 themeOf TLR4,Increased
R3764 T4819 T4824 themeOf TLR4,levels
R3765 T4820 T4825 themeOf TLR4,level
R3766 T4821 T4826 themeOf TLR4,increased
R3767 T4822 T4828 themeOf TLR4,decreased
R3768 T4822 T4827 themeOf TLR4,increased
R4093 T5292 T5301 themeOf TLR4,Expression
R4094 T5292 T5300 themeOf TLR4,Increased
R4095 T5293 T5303 themeOf TLR4,increased
R4096 T5294 T5302 themeOf TLR4,expression
R4097 T5297 T5306 themeOf TLR4,expression
R4098 T5301 T5300 themeOf Expression,Increased
R4099 T5306 T5305 themeOf expression,decreased
R4100 T5306 T5304 themeOf expression,increased
R4256 T5571 T5574 themeOf TLR4,detected
R4257 T5573 T5575 themeOf TLR4,immunoreactivity
R4596 T6005 T6007 themeOf TLR4,Activation
R6944 T8900 T8924 themeOf TLR4,recognized
R6947 T8902 T8925 themeOf TLR4,detected
R6948 T8903 T8928 themeOf TLR4,transcription
R6949 T8904 T8927 themeOf TLR4,expression
R6950 T8905 T8930 themeOf TLR4,distributed
R6951 T8905 T8929 themeOf TLR4,detected
R6952 T8906 T8932 themeOf TLR4,expression
R6965 T8927 T8926 themeOf expression,elevated
R6973 T8928 T8926 themeOf transcription,elevated
R6974 T8932 T8931 themeOf expression,increased
R6953 T8935 T8934 themeOf phosphorylation,stimulates
R6954 T8910 T8933 themeOf TLR4,Activation
R6955 T8936 T8934 themeOf degradation,stimulates
R6956 T8911 T8935 themeOf IκBα,phosphorylation
R6957 T8911 T8936 themeOf IκBα,degradation
R6958 T8912 T8937 themeOf TLR4,expression
R6959 T8915 T8938 themeOf TLR4,recognize
R6960 T8916 T8939 themeOf HSP70,upregulated
R6962 T8917 T8939 themeOf HSP32,upregulated
R6964 T8918 T8939 themeOf HSP27,upregulated

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T8707 17697-17704 Binding denotes ligands
T8706 17446-17457 Positive_regulation denotes upregulated
T8705 16859-16869 Positive_regulation denotes stimulates
T8704 16870-16880 Positive_regulation denotes activation
T8703 16813-16823 Gene_expression denotes expression
T8702 16415-16426 Protein_catabolism denotes degradation
T8701 16395-16410 Phosphorylation denotes phosphorylation
T8700 16379-16389 Positive_regulation denotes stimulates
T8699 16360-16370 Positive_regulation denotes Activation
T8698 15633-15643 Gene_expression denotes expression
T4785 9809-9818 Positive_regulation denotes increased
T4784 9657-9663 Transcription denotes levels
T4783 9606-9610 Transcription denotes mRNA
T4782 9611-9620 Positive_regulation denotes Increased
T4781 9888-9892 Protein denotes TLR4
T4780 9790-9794 Protein denotes TLR4
T4779 9706-9710 Protein denotes TLR4
T4778 9647-9651 Protein denotes TLR4
T4777 9601-9605 Protein denotes TLR4
T4346 9271-9274 Protein denotes P50
T4345 9263-9266 Protein denotes P65
T3961 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3960 8250-8255 Protein denotes GAPDH
T3679 7559-7565 Protein denotes avidin
T3678 7387-7391 Protein denotes TLR4
T3396 7280-7289 Transcription denotes expressed
T3395 7319-7326 Protein denotes β-actin
T3394 7306-7310 Protein denotes TLR4
T3393 7266-7270 Protein denotes TLR4
T3392 6875-6882 Protein denotes β-actin
T3391 6786-6790 Protein denotes TLR4
T3390 6742-6749 Protein denotes β-actin
T3389 6733-6737 Protein denotes TLR4
T3388 6635-6642 Protein denotes β-actin
T3387 6614-6633 Protein denotes The house keep gene
T3386 6594-6612 Protein denotes Taq DNA polymerase
T3385 6494-6498 Protein denotes TLR4
T3384 5834-5838 Protein denotes TLR4
T1665 3235-3248 Transcription denotes transcription
T1664 2435-2445 Positive_regulation denotes activation
T1663 3474-3478 Protein denotes TLR4
T1662 3423-3427 Protein denotes TLR4
T1661 3284-3288 Protein denotes TLR4
T1660 3252-3256 Protein denotes TLR4
T1659 3168-3172 Protein denotes TLR4
T1658 2944-2948 Protein denotes TLR4
T1657 2449-2453 Protein denotes TLR4
T633 183-203 Protein denotes Toll-like receptor 4
T634 206-210 Protein denotes TLR4
T635 388-392 Protein denotes TLR4
T636 537-541 Protein denotes TLR4
T637 564-568 Protein denotes TLR4
T638 636-640 Protein denotes TLR4
T639 682-703 Protein denotes inhibitors of kappa B
T640 707-711 Protein denotes IκBα
T641 885-889 Protein denotes TLR4
T642 1104-1108 Protein denotes IκBα
T643 1242-1246 Protein denotes TLR4
T645 523-533 Gene_expression denotes expression
T646 663-678 Phosphorylation denotes phosphorylation
T647 1004-1013 Negative_regulation denotes decreased
T648 1024-1034 Positive_regulation denotes maintained
T649 921-930 Positive_regulation denotes increased
T632 14-18 Protein denotes TLR4
T644 19-27 Positive_regulation denotes Mediated
T5544 10926-10930 Protein denotes TLR4
T5543 10908-10912 Protein denotes TLR4
T5542 10846-10850 Protein denotes TLR4
T5236 10501-10511 Gene_expression denotes expression
T5235 10629-10638 Negative_regulation denotes decreased
T5234 10534-10543 Positive_regulation denotes increased
T5233 10278-10288 Gene_expression denotes expression
T5232 10237-10246 Positive_regulation denotes increased
T5231 10155-10165 Gene_expression denotes Expression
T5230 10182-10191 Positive_regulation denotes Increased
T5229 10803-10807 Protein denotes TLR4
T5228 10742-10746 Protein denotes TLR4
T5227 10515-10519 Protein denotes TLR4
T5226 10440-10444 Protein denotes TLR4
T5225 10395-10399 Protein denotes TLR4
T5224 10292-10296 Protein denotes TLR4
T5223 10247-10251 Protein denotes TLR4
T5222 10169-10173 Protein denotes TLR4
T4787 9922-9931 Positive_regulation denotes increased
T4786 10017-10026 Negative_regulation denotes decreased
T8697 15623-15632 Positive_regulation denotes increased
T8696 15188-15201 Transcription denotes transcription
T8695 15276-15284 Positive_regulation denotes elevated
T8694 15225-15235 Gene_expression denotes expression
T8693 18136-18140 Protein denotes TLR4
T8692 18035-18039 Protein denotes TLR4
T8691 17844-17848 Protein denotes TLR4
T8690 17715-17719 Protein denotes TLR4
T8689 17692-17696 Protein denotes TLR4
T8688 17382-17387 Protein denotes HSP27
T8687 17375-17380 Protein denotes HSP32
T8686 17368-17373 Protein denotes HSP70
T8685 17041-17045 Protein denotes TLR4
T8684 17008-17012 Protein denotes TLR4
T8683 16888-16892 Protein denotes TLR4
T8682 16827-16831 Protein denotes TLR4
T8681 16390-16394 Protein denotes IκBα
T8680 16374-16378 Protein denotes TLR4
T8679 16327-16331 Protein denotes TLR4
T8678 16167-16171 Protein denotes TLR4
T8677 15919-15923 Protein denotes TLR4
T8676 15647-15651 Protein denotes TLR4
T8675 15422-15426 Protein denotes TLR4
T8674 15239-15243 Protein denotes TLR4
T8673 15205-15209 Protein denotes TLR4
T8672 15144-15148 Protein denotes TLR4
T8671 15018-15022 Protein denotes TLR4
T8670 14523-14527 Protein denotes TLR4
T5963 11311-11321 Positive_regulation denotes Activation
T5962 11281-11289 Positive_regulation denotes Mediated
T5961 11595-11599 Protein denotes TLR4
T5960 11325-11329 Protein denotes TLR4
T5959 11276-11280 Protein denotes TLR4
T5546 11112-11116 Protein denotes TLR4
T5545 10995-10999 Protein denotes TLR4
R528 T632 T644 themeOf TLR4,Mediated
R529 T636 T645 themeOf TLR4,expression
R530 T638 T646 themeOf TLR4,phosphorylation
R531 T639 T646 themeOf inhibitors of kappa B,phosphorylation
R532 T641 T647 themeOf TLR4,decreased
R533 T641 T648 themeOf TLR4,maintained
R534 T641 T649 themeOf TLR4,increased
R1289 T1657 T1664 themeOf TLR4,activation
R1290 T1660 T1665 themeOf TLR4,transcription
R2741 T3393 T3396 themeOf TLR4,expressed
R3741 T4777 T4783 themeOf TLR4,mRNA
R3742 T4777 T4782 themeOf TLR4,Increased
R3743 T4778 T4784 themeOf TLR4,levels
R3744 T4780 T4785 themeOf TLR4,increased
R3745 T4781 T4786 themeOf TLR4,decreased
R3746 T4781 T4787 themeOf TLR4,increased
R4061 T5222 T5231 themeOf TLR4,Expression
R4062 T5222 T5230 themeOf TLR4,Increased
R4063 T5223 T5232 themeOf TLR4,increased
R4064 T5224 T5233 themeOf TLR4,expression
R4065 T5227 T5236 themeOf TLR4,expression
R4066 T5231 T5230 themeOf Expression,Increased
R4067 T5236 T5235 themeOf expression,decreased
R4068 T5236 T5234 themeOf expression,increased
R4571 T5959 T5962 themeOf TLR4,Mediated
R4572 T5960 T5963 themeOf TLR4,Activation
R6846 T8673 T8694 themeOf TLR4,expression
R6847 T8673 T8696 themeOf TLR4,transcription
R6849 T8674 T8694 themeOf TLR4,expression
R6851 T8676 T8698 themeOf TLR4,expression
R6853 T8680 T8699 themeOf TLR4,Activation
R6854 T8681 T8701 themeOf IκBα,phosphorylation
R6855 T8681 T8702 themeOf IκBα,degradation
R6856 T8682 T8703 themeOf TLR4,expression
R6857 T8683 T8704 themeOf TLR4,activation
R6858 T8686 T8706 themeOf HSP70,upregulated
R6859 T8687 T8706 themeOf HSP32,upregulated
R6861 T8688 T8706 themeOf HSP27,upregulated
R6862 T8689 T8707 themeOf TLR4,ligands
R6864 T8694 T8695 themeOf expression,elevated
R6865 T8694 T8695 themeOf expression,elevated
R6867 T8696 T8695 themeOf transcription,elevated
R6868 T8698 T8697 themeOf expression,increased
R6870 T8699 T8700 causeOf Activation,stimulates
R6871 T8699 T8700 causeOf Activation,stimulates
R6872 T8701 T8700 themeOf phosphorylation,stimulates
R6873 T8702 T8700 themeOf degradation,stimulates
R6875 T8704 T8705 themeOf activation,stimulates

DLUT931

Id Subject Object Predicate Lexical cue
T677 14-18 Protein denotes TLR4
T8726 17382-17387 Protein denotes HSP27
T8725 17375-17380 Protein denotes HSP32
T8724 17368-17373 Protein denotes HSP70
T8723 17041-17045 Protein denotes TLR4
T8722 17008-17012 Protein denotes TLR4
T8721 16888-16892 Protein denotes TLR4
T8720 16827-16831 Protein denotes TLR4
T8719 16390-16394 Protein denotes IκBα
T8718 16374-16378 Protein denotes TLR4
T8717 16327-16331 Protein denotes TLR4
T8716 16167-16171 Protein denotes TLR4
T8715 15919-15923 Protein denotes TLR4
T8714 15647-15651 Protein denotes TLR4
T8713 15422-15426 Protein denotes TLR4
T8712 15239-15243 Protein denotes TLR4
T8711 15205-15209 Protein denotes TLR4
T8710 15144-15148 Protein denotes TLR4
T8709 15018-15022 Protein denotes TLR4
T8708 14523-14527 Protein denotes TLR4
T5967 11311-11321 Positive_regulation denotes Activation
T5966 11595-11599 Protein denotes TLR4
T5965 11325-11329 Protein denotes TLR4
T5964 11276-11280 Protein denotes TLR4
T5556 11112-11116 Protein denotes TLR4
T5555 10995-10999 Protein denotes TLR4
T5554 10926-10930 Protein denotes TLR4
T5553 10908-10912 Protein denotes TLR4
T5552 10846-10850 Protein denotes TLR4
T5260 10629-10638 Negative_regulation denotes decreased
T5259 10587-10593 Positive_regulation denotes peaked
T5258 10534-10543 Positive_regulation denotes increased
T5257 10501-10511 Gene_expression denotes expression
T5256 10278-10288 Gene_expression denotes expression
T5255 10237-10246 Positive_regulation denotes increased
T5254 10182-10191 Positive_regulation denotes Increased
T5253 10155-10165 Gene_expression denotes Expression
T5252 10803-10807 Protein denotes TLR4
T5251 10742-10746 Protein denotes TLR4
T5250 10515-10519 Protein denotes TLR4
T5249 10440-10444 Protein denotes TLR4
T5248 10395-10399 Protein denotes TLR4
T5247 10292-10296 Protein denotes TLR4
T5246 10247-10251 Protein denotes TLR4
T4802 10017-10026 Negative_regulation denotes decreased
T4801 9975-9981 Positive_regulation denotes peaked
T4800 9922-9931 Positive_regulation denotes increased
T4799 9893-9897 Transcription denotes mRNA
T4798 9809-9818 Positive_regulation denotes increased
T4797 9795-9799 Transcription denotes mRNA
T4796 9711-9715 Transcription denotes mRNA
T4795 9657-9663 Transcription denotes levels
T4794 9611-9620 Positive_regulation denotes Increased
T4793 9606-9610 Transcription denotes mRNA
T4792 9888-9892 Protein denotes TLR4
T4791 9790-9794 Protein denotes TLR4
T4790 9706-9710 Protein denotes TLR4
T4789 9647-9651 Protein denotes TLR4
T4788 9601-9605 Protein denotes TLR4
T5245 10169-10173 Protein denotes TLR4
T4350 9271-9274 Protein denotes P50
T4349 9263-9266 Protein denotes P65
T3965 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3964 8250-8255 Protein denotes GAPDH
T3685 7559-7565 Protein denotes avidin
T3684 7387-7391 Protein denotes TLR4
T3413 7311-7315 Transcription denotes mRNA
T3412 7271-7275 Transcription denotes mRNA
T3411 7253-7262 Transcription denotes abundance
T3410 5839-5843 Transcription denotes mRNA
T3409 5821-5830 Transcription denotes Detection
T3408 7319-7326 Protein denotes β-actin
T3407 7306-7310 Protein denotes TLR4
T3406 7266-7270 Protein denotes TLR4
T3405 6875-6882 Protein denotes β-actin
T3404 6786-6790 Protein denotes TLR4
T3403 6742-6749 Protein denotes β-actin
T3402 6733-6737 Protein denotes TLR4
T3401 6635-6642 Protein denotes β-actin
T3400 6614-6633 Protein denotes The house keep gene
T3399 6594-6612 Protein denotes Taq DNA polymerase
T3398 6494-6498 Protein denotes TLR4
T3397 5834-5838 Protein denotes TLR4
T3414 7327-7331 Transcription denotes mRNA
T1675 3235-3248 Transcription denotes transcription
T1674 2516-2527 Binding denotes dissociates
T1673 2435-2445 Positive_regulation denotes activation
T1672 3474-3478 Protein denotes TLR4
T1671 3423-3427 Protein denotes TLR4
T1670 3284-3288 Protein denotes TLR4
T1669 3252-3256 Protein denotes TLR4
T1668 3168-3172 Protein denotes TLR4
T1667 2944-2948 Protein denotes TLR4
T1666 2449-2453 Protein denotes TLR4
T696 1247-1255 Positive_regulation denotes mediated
T695 1139-1148 Positive_regulation denotes increased
T694 1024-1034 Positive_regulation denotes maintained
T693 1004-1013 Negative_regulation denotes decreased
T690 663-678 Phosphorylation denotes phosphorylation
T689 523-533 Gene_expression denotes expression
T688 1242-1246 Protein denotes TLR4
T687 1104-1108 Protein denotes IκBα
T686 885-889 Protein denotes TLR4
T685 707-711 Protein denotes IκBα
T684 682-703 Protein denotes inhibitors of kappa B
T683 636-640 Protein denotes TLR4
T682 564-568 Protein denotes TLR4
T681 537-541 Protein denotes TLR4
T680 388-392 Protein denotes TLR4
T679 206-210 Protein denotes TLR4
T678 183-203 Protein denotes Toll-like receptor 4
T691 921-930 Positive_regulation denotes increased
T692 962-968 Positive_regulation denotes peaked
T8729 17844-17848 Protein denotes TLR4
T8728 17715-17719 Protein denotes TLR4
T8727 17692-17696 Protein denotes TLR4
T8747 18141-18149 Positive_regulation denotes mediated
T8746 17446-17457 Positive_regulation denotes upregulated
T8745 16859-16869 Positive_regulation denotes stimulates
T8744 16870-16880 Positive_regulation denotes activation
T8743 16813-16823 Gene_expression denotes expression
T8742 16379-16389 Positive_regulation denotes stimulates
T8741 16415-16426 Protein_catabolism denotes degradation
T8740 16395-16410 Phosphorylation denotes phosphorylation
T8739 16360-16370 Positive_regulation denotes Activation
T8738 16172-16180 Positive_regulation denotes mediated
T8737 15623-15632 Positive_regulation denotes increased
T8736 15659-15666 Positive_regulation denotes related
T8735 15633-15643 Gene_expression denotes expression
T8734 15276-15284 Positive_regulation denotes elevated
T8733 15225-15235 Gene_expression denotes expression
T8732 15188-15201 Transcription denotes transcription
T8731 18136-18140 Protein denotes TLR4
T8730 18035-18039 Protein denotes TLR4
R2745 T3406 T3412 themeOf TLR4,mRNA
R2746 T3407 T3413 themeOf TLR4,mRNA
R2747 T3408 T3414 themeOf β-actin,mRNA
R3747 T4788 T4793 themeOf TLR4,mRNA
R3748 T4789 T4795 themeOf TLR4,levels
R3749 T4790 T4796 themeOf TLR4,mRNA
R3750 T4791 T4797 themeOf TLR4,mRNA
R3751 T4792 T4799 themeOf TLR4,mRNA
R3752 T4792 T4802 themeOf TLR4,decreased
R3753 T4793 T4794 themeOf mRNA,Increased
R3754 T4797 T4798 themeOf mRNA,increased
R3755 T4799 T4800 themeOf mRNA,increased
R3756 T4799 T4801 themeOf mRNA,peaked
R3757 T4799 T4802 themeOf mRNA,decreased
R4069 T5245 T5253 themeOf TLR4,Expression
R4070 T5246 T5255 themeOf TLR4,increased
R4071 T5247 T5256 themeOf TLR4,expression
R4072 T5250 T5257 themeOf TLR4,expression
R4073 T5253 T5254 themeOf Expression,Increased
R491 T681 T689 themeOf TLR4,expression
R492 T683 T690 themeOf TLR4,phosphorylation
R493 T684 T690 themeOf inhibitors of kappa B,phosphorylation
R494 T685 T690 themeOf IκBα,phosphorylation
R495 T686 T691 themeOf TLR4,increased
R496 T686 T692 themeOf TLR4,peaked
R497 T686 T693 themeOf TLR4,decreased
R498 T686 T694 themeOf TLR4,maintained
R499 T687 T695 themeOf IκBα,increased
R500 T688 T696 themeOf TLR4,mediated
R1291 T1666 T1673 themeOf TLR4,activation
R1292 T1666 T1674 themeOf TLR4,dissociates
R1293 T1669 T1675 themeOf TLR4,transcription
R2742 T3397 T3409 themeOf TLR4,Detection
R2743 T3397 T3410 themeOf TLR4,mRNA
R2744 T3406 T3411 themeOf TLR4,abundance
R4074 T5256 T5255 themeOf expression,increased
R4075 T5257 T5258 themeOf expression,increased
R4076 T5257 T5259 themeOf expression,peaked
R4077 T5257 T5260 themeOf expression,decreased
R4573 T5965 T5967 themeOf TLR4,Activation
R6852 T8711 T8732 themeOf TLR4,transcription
R6860 T8712 T8733 themeOf TLR4,expression
R6863 T8714 T8735 themeOf TLR4,expression
R6866 T8716 T8738 themeOf TLR4,mediated
R6869 T8718 T8739 themeOf TLR4,Activation
R6874 T8719 T8740 themeOf IκBα,phosphorylation
R6876 T8719 T8741 themeOf IκBα,degradation
R6885 T8733 T8734 themeOf expression,elevated
R6887 T8735 T8736 themeOf expression,related
R6888 T8735 T8737 themeOf expression,increased
R6892 T8740 T8742 themeOf phosphorylation,stimulates
R6877 T8720 T8743 themeOf TLR4,expression
R6878 T8721 T8744 themeOf TLR4,activation
R6879 T8724 T8746 themeOf HSP70,upregulated
R6880 T8725 T8746 themeOf HSP32,upregulated
R6881 T8726 T8746 themeOf HSP27,upregulated
R6883 T8731 T8747 themeOf TLR4,mediated
R6890 T8739 T8742 causeOf Activation,stimulates
R6891 T8739 T8742 causeOf Activation,stimulates
R6893 T8741 T8742 themeOf degradation,stimulates
R6894 T8744 T8745 themeOf activation,stimulates

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T775 11-42 Positive_regulation denotes of TLR4-Mediated NFκB Signaling
T750 28-32 Protein denotes NFκB
T763 14-27 Protein denotes TLR4-Mediated
T773 11-42 Regulation denotes of TLR4-Mediated NFκB Signaling
T9012 16267-16271 Protein denotes NFκB
T9011 16236-16243 Protein denotes of NFκB
T9010 15158-15165 Protein denotes protein
T9009 17577-17618 Entity denotes these molecules produced in damaged brain
T9008 13444-13452 Protein denotes of genes
T9007 13107-13116 Protein denotes cytokines
T9006 15202-15209 Protein denotes of TLR4
T9005 13836-13854 Protein denotes Activation of NFκB
T9004 17681-17744 Entity denotes endogenous TLR4 ligands, activate TLR4-mediated NFκB signaling,
T9003 13362-13366 Protein denotes NFκB
T8956 14505-14512 Protein denotes of NFκB
T8955 17309-17317 Protein denotes of genes
T8954 18150-18154 Protein denotes NFκB
T8953 16390-16394 Protein denotes IκBα
T8952 18049-18053 Protein denotes NFκB
T8951 13805-13834 Protein denotes of selected target genes [15]
T8950 15644-15651 Protein denotes of TLR4
T8949 15032-15036 Protein denotes NFκB
T8948 17533-17549 Entity denotes blood cells [21]
T8947 13981-13985 Protein denotes NFκB
T8946 17199-17216 Entity denotes of macromolecules
T8945 12163-12179 Entity denotes the thrombolytic
T8944 16463-16470 Protein denotes of NFκB
T8943 16167-16180 Protein denotes TLR4-mediated
T8942 13118-13128 Entity denotes leukocytes
T8941 16371-16378 Protein denotes of TLR4
T8940 15418-15434 Protein denotes The TLR4 protein
T8899 18136-18164 Positive_regulation denotes TLR4-mediated NFκB signaling
T8898 16488-16567 Transcription denotes transcription of genes associated with innate immune responses and inflammation
T8897 14441-14521 Positive_regulation denotes TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13]
T8887 17844-17870 Localization denotes TLR4 in hemorrhagic brain
T8886 17715-17743 Positive_regulation denotes TLR4-mediated NFκB signaling
T8885 15623-15651 Gene_expression denotes increased expression of TLR4
T8884 15623-15651 Positive_regulation denotes increased expression of TLR4
T8883 15010-15046 Positive_regulation denotes between TLR4-mediated NFκB signaling
T8882 13967-13994 Negative_regulation denotes Inhibition of NFκB activity
T8881 13774-13834 Gene_expression denotes associated with the expression of selected target genes [15]
T8880 15221-15261 Gene_expression denotes the expression of TLR4 protein after ICH
T8879 16390-16410 Phosphorylation denotes IκBα phosphorylation
T8878 14839-14895 Positive_regulation denotes glutamate receptor activation induced by red blood cells
T8877 18032-18063 Positive_regulation denotes of TLR4-mediated NFκB signaling
T8876 16964-16982 Positive_regulation denotes activation of NFκB
T8875 15010-15046 Regulation denotes between TLR4-mediated NFκB signaling
T8874 18136-18164 Regulation denotes TLR4-mediated NFκB signaling
T8873 16763-16785 Positive_regulation denotes the activation of NFκB
T8872 16360-16378 Positive_regulation denotes Activation of TLR4
T8871 16164-16195 Regulation denotes of TLR4-mediated NFκB signaling
T8870 16833-16916 Positive_regulation denotes Our data suggest that ICH stimulates activation of the TLR4/NFκB signaling pathway,
T6029 11592-11623 Positive_regulation denotes of TLR4-mediated NFκB signaling
T6028 11592-11623 Regulation denotes of TLR4-mediated NFκB signaling
T6027 11311-11329 Positive_regulation denotes Activation of TLR4
T6026 11504-11564 Transcription denotes the transcription of genes related to inflammatory responses
T6025 11441-11489 Positive_regulation denotes NFκB translocates into the nucleus and activates
T6024 11273-11310 Positive_regulation denotes of TLR4-Mediated NF-Kappa-B Signaling
T6023 11273-11310 Regulation denotes of TLR4-Mediated NF-Kappa-B Signaling
T6022 11441-11564 Regulation denotes NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses
T6021 11595-11608 Protein denotes TLR4-mediated
T6020 11322-11329 Protein denotes of TLR4
T6019 11609-11613 Protein denotes NFκB
T6018 11648-11676 Entity denotes inhibitor of kappa-B (p-IκB)
T6017 11690-11697 Protein denotes of NFκB
T6016 11416-11433 Protein denotes NF-kappa-B (NFκB)
T6015 11464-11475 Entity denotes the nucleus
T6014 11276-11289 Protein denotes TLR4-Mediated
T6013 11290-11300 Protein denotes NF-Kappa-B
T6012 11945-11952 Protein denotes of NFκB
T6011 11361-11388 Entity denotes inhibitor of kappa-B (IκB),
T6010 11441-11445 Protein denotes NFκB
T6009 11428-11432 Protein denotes NFκB
T6008 11522-11564 Protein denotes of genes related to inflammatory responses
T5583 10922-10930 Protein denotes the TLR4
T5582 10843-10850 Protein denotes of TLR4
T5581 11112-11116 Protein denotes TLR4
T5580 10995-10999 Protein denotes TLR4
T5579 11068-11072 Entity denotes sham
T5578 10908-10912 Protein denotes TLR4
T5577 11198-11213 Entity denotes thalamic nuclei
T5576 10905-10920 Protein denotes of TLR4 protein
T5328 10497-10571 Positive_regulation denotes The expression of TLR4 significantly increased starting from 6 hours after
T5327 10274-10304 Gene_expression denotes the expression of TLR4 protein
T5326 10155-10207 Positive_regulation denotes Expression of TLR4 Protein Increased in Brain Tissue
T5325 10497-10519 Gene_expression denotes The expression of TLR4
T5324 10255-10272 Protein denotes the protein level
T5323 10233-10273 Protein denotes the increased TLR4 at the protein level,
T5322 10512-10519 Protein denotes of TLR4
T5321 10274-10304 Protein denotes the expression of TLR4 protein
T5320 10289-10296 Protein denotes of TLR4
T5319 10440-10452 Protein denotes TLR4 protein
T5318 10166-10181 Entity denotes of TLR4 Protein
T5317 10702-10705 Entity denotes P <
T5316 10808-10822 Protein denotes mRNA after ICH
T5315 10169-10173 Protein denotes TLR4
T5314 10371-10390 Entity denotes specific antibodies
T5313 10395-10399 Protein denotes TLR4
T5312 10742-10746 Protein denotes TLR4
T5311 10683-10686 Entity denotes 7th
T5310 10440-10444 Protein denotes TLR4
T5309 10799-10807 Protein denotes the TLR4
T5308 10739-10754 Protein denotes of TLR4 protein
T5307 10577-10578 Entity denotes P
T3988 7770-7787 Protein denotes Cellular proteins
T3987 8209-8227 Entity denotes The same membranes
T3986 8176-8179 Entity denotes ECL
T3985 8072-8114 Entity denotes peroxidase-conjugated secondary antibodies
T3984 7961-7964 Protein denotes ECL
T3983 7898-7939 Entity denotes Hybond ECL membranes (Amersham Pharmacia,
T3982 8083-8114 Entity denotes conjugated secondary antibodies
T3981 8245-8255 Protein denotes anti-GAPDH
T3980 7905-7908 Protein denotes ECL
T3979 7858-7872 Entity denotes polyacrylamide
T3978 8072-8114 Protein denotes peroxidase-conjugated secondary antibodies
T3977 7854-7892 Entity denotes SDS-polyacrylamide gel and transferred
T3976 7995-8027 Protein denotes the appropriate primary antibody
T3975 7957-7974 Entity denotes The ECL membranes
T3974 7854-7857 Protein denotes SDS
T3973 8257-8309 Protein denotes glyceraldehyde-3-phosphate dehydrogenase, Biodesign,
T3704 7503-7538 Protein_modification denotes The biotinylated secondary antibody
T3703 7588-7609 Entity denotes ABC reagent, SC-2018)
T3702 7566-7576 Protein denotes peroxidase
T3701 7702-7720 Entity denotes primary antibodies
T3700 7387-7391 Protein denotes TLR4
T3699 7435-7464 Protein denotes The primary antibody employed
T3698 7469-7501 Protein denotes rabbit anti-TLR4 (WuHan, BA1717)
T3697 7543-7586 Entity denotes antibody-biotin-avidin-peroxidase complexes
T3696 7503-7538 Protein denotes The biotinylated secondary antibody
T3695 7677-7748 Entity denotes Slides processed without primary antibodies served as negative controls
T3694 7552-7558 Entity denotes biotin
T3693 7559-7565 Protein denotes avidin
T3692 7629-7634 Protein denotes Santa
T3691 7543-7551 Entity denotes antibody
T3491 7115-7118 Protein denotes PCR
T3490 6635-6642 Protein denotes β-actin
T3489 6777-6780 Protein denotes Gen
T3488 6614-6643 Protein denotes The house keep gene (β-actin)
T3487 6847-6882 Protein denotes 5′-CAGGATGACACCATTGAAGC-3′; β-actin
T3486 5831-5843 Protein denotes of TLR4 mRNA
T3485 6786-6790 Protein denotes TLR4
T3484 6490-6532 Protein denotes the TLR4 gene fragment with 1× PCR buffer,
T3483 5883-5886 Protein denotes RNA
T3482 6681-6684 Protein denotes PCR
T3481 6521-6524 Protein denotes PCR
T3480 6494-6498 Protein denotes TLR4
T3479 5834-5838 Protein denotes TLR4
T3478 6181-6185 Entity denotes A260
T3477 6235-6242 Protein denotes of mRNA
T3476 6339-6377 Protein denotes Superscript First-Strand Synthesis Kit
T3475 5981-5984 Protein denotes RNA
T3474 6591-6612 Entity denotes 2u Taq DNA polymerase
T2671 5744-5761 Entity denotes the normal saline
T1728 2537-2554 Protein denotes NF-kappa-B (NFκB)
T1727 3474-3487 Protein denotes TLR4-mediated
T1726 2254-2283 Protein denotes downstream signaling proteins
T1725 3284-3297 Protein denotes TLR4-mediated
T1724 1517-1536 Entity denotes of the thrombolytic
T1723 2939-2948 Protein denotes that TLR4
T1754 3231-3261 Transcription denotes the transcription of TLR4 gene
T1753 2299-2321 Transcription denotes transcription of genes
T1752 2431-2453 Positive_regulation denotes the activation of TLR4
T1751 3471-3497 Regulation denotes of TLR4-mediated signaling
T1750 2254-2283 Positive_regulation denotes downstream signaling proteins
T1749 2245-2283 Binding denotes recruits downstream signaling proteins
T1748 2626-2693 Transcription denotes the transcription of genes related to inflammatory responses [5, 6]
T1747 2562-2625 Binding denotes NFκB trans-locates into the nucleus and activates and regulates
T1746 2331-2364 Binding denotes inflammation-associated molecules
T1745 3281-3307 Regulation denotes of TLR4-mediated signaling
T1744 2409-2430 Entity denotes with specific ligand,
T1743 2157-2179 Protein denotes transmembrane proteins
T1742 3252-3256 Protein denotes TLR4
T1741 2586-2597 Entity denotes the nucleus
T1740 2188-2224 Entity denotes as signal transduction molecules [4]
T1739 2549-2553 Protein denotes NFκB
T1738 2313-2321 Protein denotes of genes
T1737 3420-3427 Protein denotes of TLR4
T1736 2485-2511 Entity denotes inhibitor of kappa-B (IκB)
T1735 2644-2652 Protein denotes of genes
T1734 2369-2378 Protein denotes cytokines
T1733 3168-3172 Protein denotes TLR4
T1732 2562-2566 Protein denotes NFκB
T1731 2446-2453 Protein denotes of TLR4
T1730 3249-3261 Protein denotes of TLR4 gene
T1729 2331-2364 Entity denotes inflammation-associated molecules
T776 1247-1270 Regulation denotes mediated NFκB signaling
T774 388-416 Positive_regulation denotes TLR4-mediated NFκB signaling
T772 1247-1270 Positive_regulation denotes mediated NFκB signaling
T771 561-624 Positive_regulation denotes of TLR4-mediated NFκB signaling in brain tissues of Wistar rats
T770 388-416 Regulation denotes TLR4-mediated NFκB signaling
T769 561-624 Regulation denotes of TLR4-mediated NFκB signaling in brain tissues of Wistar rats
T768 881-956 Positive_regulation denotes the TLR4 mRNA and protein significantly increased starting at 6 hours after
T767 881-956 Positive_regulation denotes the TLR4 mRNA and protein significantly increased starting at 6 hours after
T766 519-541 Gene_expression denotes the expression of TLR4
T765 1237-1246 Protein denotes that TLR4
T764 731-738 Protein denotes of NFκB
T762 534-541 Protein denotes of TLR4
T761 1186-1192 Entity denotes saline
T760 388-401 Protein denotes TLR4-mediated
T759 790-793 Protein denotes PCR
T758 705-711 Protein denotes p-IκBα
T757 1060-1063 Entity denotes 7th
T756 899-906 Protein denotes protein
T755 1079-1080 Entity denotes P
T754 650-657 Protein denotes protein
T753 246-250 Protein denotes NFκB
T752 682-713 Protein denotes inhibitors of kappa B (p-IκBα),
T751 564-577 Protein denotes TLR4-mediated
T749 865-871 Entity denotes saline
T748 881-894 Protein denotes the TLR4 mRNA
T747 636-640 Protein denotes TLR4
T746 1102-1108 Protein denotes p-IκBα
T745 885-889 Protein denotes TLR4
T744 183-212 Protein denotes Toll-like receptor 4- (TLR4-)
T743 1256-1260 Protein denotes NFκB
T8888 14179-14226 Positive_regulation denotes NFκB is activated in the brain subjected to ICH
T8896 14774-14796 Positive_regulation denotes the activation of NFκB
T8895 13430-13507 Transcription denotes transcription of genes associated with immune responses and inflammation [12,
T8894 15167-15261 Transcription denotes Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH
T8893 16809-16831 Gene_expression denotes the expression of TLR4
T8892 17715-17743 Regulation denotes TLR4-mediated NFκB signaling
T8891 16164-16195 Positive_regulation denotes of TLR4-mediated NFκB signaling
T8890 14490-14521 Positive_regulation denotes the activation of NFκB [12, 13]
T8889 18032-18063 Regulation denotes of TLR4-mediated NFκB signaling
T3460 7306-7310 Protein denotes TLR4
T3459 6729-6737 Protein denotes the TLR4
T3458 7303-7315 Protein denotes of TLR4 mRNA
T3457 7263-7275 Protein denotes of TLR4 mRNA
T3456 6190-6195 Entity denotes A280 
T3455 7316-7331 Protein denotes to β-actin mRNA
T3454 7266-7270 Protein denotes TLR4
T3453 6591-6612 Protein denotes 2u Taq DNA polymerase
T3452 7157-7168 Entity denotes agarose gel
T3451 6490-6532 Protein denotes the TLR4 gene fragment with 1× PCR buffer,
T3450 6742-6784 Protein denotes β-actin gene sequences reported in GenBank
T3449 6563-6567 Entity denotes NTP,
T3448 7157-7164 Entity denotes agarose
T3447 6382-6402 Protein denotes RT-PCR (promega Inc)
T3446 7316-7331 Protein denotes to β-actin mRNA
T3445 6270-6273 Protein denotes RNA
T3444 5973-5998 Protein denotes P Total RNA isolation Kit
T3443 6079-6091 Protein denotes of total RNA
T3442 6777-6784 Protein denotes GenBank
T3441 5858-5867 Protein denotes of RT-PCR
T2228 4353-4357 Entity denotes Para
T2227 3747-3800 Entity denotes n = 10, without any treatment), normal saline control
T2226 4093-4106 Entity denotes normal saline
T2225 4431-4440 Entity denotes paraffin,
T2224 4312-4343 Entity denotes of normal saline followed by 4%
T2223 4353-4370 Entity denotes Para formaldehyde
T2222 3802-3808 Entity denotes S, n =
T2221 4647-4653 Protein denotes RT-PCR
T2220 4584-4592 Entity denotes Ketamine
T2219 3909-3912 Entity denotes n =
T2218 3786-3792 Entity denotes saline
T2678 5164-5171 Protein denotes sterile
T2677 5267-5278 Entity denotes the midline
T2676 5590-5605 Entity denotes of the infusion
T2675 4895-4943 Entity denotes intra-peritoneal sodium pentobarbital (60 mg/kg)
T2674 5143-5154 Entity denotes the midline
T2673 5442-5453 Entity denotes the midline
T2672 5776-5800 Entity denotes only 75 μL normal saline
T739 1126-1133 Protein denotes of NFκB
T740 578-582 Protein denotes NFκB
T741 402-406 Protein denotes NFκB
T742 636-645 Protein denotes TLR4 mRNA
T9002 15018-15031 Protein denotes TLR4-mediated
T9001 17145-17165 Entity denotes endogenous molecules
T9000 17289-17295 Entity denotes cells,
T8999 16327-16340 Protein denotes TLR4-mediated
T8998 12498-12502 Protein denotes Mass
T8997 17692-17696 Protein denotes TLR4
T8996 15919-15945 Protein denotes TLR4-mediated-NFκB pathway
T8995 17382-17387 Protein denotes HSP27
T8994 14179-14183 Protein denotes NFκB
T8993 17008-17021 Protein denotes TLR4-mediated
T8992 17844-17869 Protein denotes TLR4 in hemorrhagic brain
T8991 17041-17045 Protein denotes TLR4
T8990 15236-15251 Protein denotes of TLR4 protein
T8989 17393-17429 Protein denotes enzymes involved in oxidative stress
T8988 17632-17643 Entity denotes blood cells
T8987 17808-17869 Entity denotes the specific endogenous ligands for TLR4 in hemorrhagic brain
T8986 15140-15153 Protein denotes the TLR4 mRNA
T8985 14332-14361 Entity denotes signal transduction molecules
T8984 14849-14857 Protein denotes receptor
T8983 16778-16785 Protein denotes of NFκB
T8982 16181-16185 Protein denotes NFκB
T8981 16824-16831 Protein denotes of TLR4
T8980 13608-13617 Protein denotes that NFκB
T8979 14839-14848 Entity denotes glutamate
T8978 16502-16510 Protein denotes of genes
T8977 17252-17265 Entity denotes intracellular
T8976 17375-17380 Protein denotes HSP32
T8975 16975-16982 Protein denotes of NFκB
T8974 16881-16916 Protein denotes of the TLR4/NFκB signaling pathway,
T8973 17715-17728 Protein denotes TLR4-mediated
T8972 17368-17380 Protein denotes HSP70, HSP32
T8971 15144-15148 Protein denotes TLR4
T8970 13087-13105 Entity denotes adhesion molecules
T8969 17507-17529 Entity denotes injured neuronal cells
T8968 18136-18149 Protein denotes TLR4-mediated
T8967 12816-12831 Entity denotes the brain cells
T8966 15919-15932 Protein denotes TLR4-mediated
T8965 13130-13145 Protein denotes immunoglobulins
T8964 16647-16654 Protein denotes of NFκB
T8963 17729-17733 Protein denotes NFκB
T8962 13674-13689 Protein denotes NFκB activation
T8961 15422-15426 Protein denotes TLR4
T8960 15550-15565 Entity denotes thalamic nuclei
T8959 15239-15243 Protein denotes TLR4
T8958 18035-18048 Protein denotes TLR4-mediated
T8957 14289-14315 Protein denotes Toll-like receptors (TLRs)
T9015 14789-14796 Protein denotes of NFκB
T9014 16893-16897 Protein denotes NFκB
T9013 14523-14564 Protein denotes TLR4, the first mammalian TLR recognized,
T4843 9884-9963 Positive_regulation denotes the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH
T4842 9647-9651 Protein denotes TLR4
T4841 9884-9907 Protein denotes the TLR4 mRNA after ICH
T4840 9601-9605 Protein denotes TLR4
T4839 9786-9799 Protein denotes the TLR4 mRNA
T4838 9706-9715 Protein denotes TLR4 mRNA
T4837 9706-9710 Protein denotes TLR4
T4836 9601-9646 Protein denotes TLR4 mRNA Increased in Brain Tissue after ICH
T4835 9965-9966 Entity denotes P
T4834 10034-10037 Entity denotes 7th
T4833 9647-9663 Protein denotes TLR4 mRNA levels
T4832 10129-10132 Entity denotes P <
T4831 9888-9892 Protein denotes TLR4
T4830 10113-10119 Entity denotes saline
T4829 9790-9794 Protein denotes TLR4
T4473 9508-9540 Entity denotes The P < .05 level of probability
T4472 9480-9485 Protein denotes ANOVA
T4471 9500-9501 Entity denotes t
T4377 9271-9274 Protein denotes P50
T4376 8899-8914 Entity denotes nuclear extract
T4375 8785-8794 Protein denotes The tubes
T4374 9263-9266 Protein denotes P65
T4373 9175-9195 Protein denotes double-stranded NFκB
T4372 8677-8705 Protein denotes The tubes containing pellets
T4371 9093-9120 Entity denotes reaction mixture containing
T4370 9196-9221 Entity denotes consensus oligonucleotide
T4369 9130-9146 Protein denotes nuclear proteins
T4368 8881-8915 Entity denotes The supernatants (nuclear extract)
T4367 8649-8675 Entity denotes nuclear extraction reagent
T4366 8718-8724 Entity denotes vortex
T4365 8506-8522 Protein denotes Nuclear proteins
T4364 8579-8615 Entity denotes of supernatant (cytoplasmic extract)
T4363 8595-8614 Entity denotes cytoplasmic extract
T4362 8955-8989 Protein denotes tube and stored at −80°C until use
T4361 9249-9259 Entity denotes antibodies
R516 T743 T772 causeOf NFκB,mediated NFκB signaling
R517 T748 T768 causeOf the TLR4 mRNA,the TLR4 mRNA and protein significantly increased starting at 6 hours after
R518 T750 T775 causeOf NFκB,of TLR4-Mediated NFκB Signaling
R519 T751 T769 causeOf TLR4-mediated,of TLR4-mediated NFκB signaling in brain tissues of Wistar rats
R520 T756 T767 causeOf protein,the TLR4 mRNA and protein significantly increased starting at 6 hours after
R521 T760 T770 causeOf TLR4-mediated,TLR4-mediated NFκB signaling
R522 T762 T766 themeOf of TLR4,the expression of TLR4
R523 T763 T773 causeOf TLR4-Mediated,of TLR4-Mediated NFκB Signaling
R524 T771 T769 themeOf of TLR4-mediated NFκB signaling in brain tissues of Wistar rats,of TLR4-mediated NFκB signaling in brain tissues of Wistar rats
R525 T772 T776 themeOf mediated NFκB signaling,mediated NFκB signaling
R526 T774 T770 themeOf TLR4-mediated NFκB signaling,TLR4-mediated NFκB signaling
R527 T775 T773 themeOf of TLR4-Mediated NFκB Signaling,of TLR4-Mediated NFκB Signaling
R540 T740 T771 causeOf NFκB,of TLR4-mediated NFκB signaling in brain tissues of Wistar rats
R541 T741 T774 causeOf NFκB,TLR4-mediated NFκB signaling
R1314 T1725 T1745 causeOf TLR4-mediated,of TLR4-mediated signaling
R1315 T1726 T1749 themeOf downstream signaling proteins,recruits downstream signaling proteins
R1316 T1726 T1750 causeOf downstream signaling proteins,downstream signaling proteins
R1317 T1727 T1751 causeOf TLR4-mediated,of TLR4-mediated signaling
R1318 T1729 T1746 themeOf inflammation-associated molecules,inflammation-associated molecules
R1319 T1730 T1754 themeOf of TLR4 gene,the transcription of TLR4 gene
R1320 T1731 T1752 themeOf of TLR4,the activation of TLR4
R1321 T1732 T1747 themeOf NFκB,NFκB trans-locates into the nucleus and activates and regulates
R1322 T1735 T1748 themeOf of genes,"the transcription of genes related to inflammatory responses [5, 6]"
R1323 T1738 T1753 themeOf of genes,transcription of genes
R4101 T5320 T5327 themeOf of TLR4,the expression of TLR4 protein
R4102 T5322 T5325 themeOf of TLR4,The expression of TLR4
R4103 T5325 T5328 causeOf The expression of TLR4,The expression of TLR4 significantly increased starting from 6 hours after
R4597 T6008 T6026 themeOf of genes related to inflammatory responses,the transcription of genes related to inflammatory responses
R4598 T6010 T6022 causeOf NFκB,NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses
R4599 T6010 T6025 themeOf NFκB,NFκB translocates into the nucleus and activates
R4600 T6013 T6024 causeOf NF-Kappa-B,of TLR4-Mediated NF-Kappa-B Signaling
R4601 T6014 T6023 causeOf TLR4-Mediated,of TLR4-Mediated NF-Kappa-B Signaling
R4602 T6019 T6029 causeOf NFκB,of TLR4-mediated NFκB signaling
R4603 T6020 T6027 themeOf of TLR4,Activation of TLR4
R4604 T6021 T6028 causeOf TLR4-mediated,of TLR4-mediated NFκB signaling
R4605 T6024 T6023 themeOf of TLR4-Mediated NF-Kappa-B Signaling,of TLR4-Mediated NF-Kappa-B Signaling
R4606 T6026 T6022 themeOf the transcription of genes related to inflammatory responses,NFκB translocates into the nucleus and activates and regulates the transcription of genes related to inflammatory responses
R4607 T6029 T6028 themeOf of TLR4-mediated NFκB signaling,of TLR4-mediated NFκB signaling
R6940 T8891 T8871 themeOf of TLR4-mediated NFκB signaling,of TLR4-mediated NFκB signaling
R6941 T8899 T8874 themeOf TLR4-mediated NFκB signaling,TLR4-mediated NFκB signaling
R6961 T8941 T8872 themeOf of TLR4,Activation of TLR4
R6963 T8943 T8871 causeOf TLR4-mediated,of TLR4-mediated NFκB signaling
R6978 T8968 T8874 causeOf TLR4-mediated,TLR4-mediated NFκB signaling
R6985 T8983 T8873 themeOf of NFκB,the activation of NFκB
R6990 T9002 T8875 causeOf TLR4-mediated,between TLR4-mediated NFκB signaling
R6967 T8950 T8885 themeOf of TLR4,increased expression of TLR4
R6968 T8951 T8881 themeOf of selected target genes [15],associated with the expression of selected target genes [15]
R6969 T8952 T8877 causeOf NFκB,of TLR4-mediated NFκB signaling
R6970 T8953 T8879 themeOf IκBα,IκBα phosphorylation
R6971 T8954 T8899 causeOf NFκB,TLR4-mediated NFκB signaling
R6972 T8956 T8890 themeOf of NFκB,"the activation of NFκB [12, 13]"
R6975 T9015 T8896 themeOf of NFκB,the activation of NFκB
R6976 T8958 T8889 causeOf TLR4-mediated,of TLR4-mediated NFκB signaling
R6977 T8963 T8886 causeOf NFκB,TLR4-mediated NFκB signaling
R6979 T8973 T8892 causeOf TLR4-mediated,TLR4-mediated NFκB signaling
R6980 T8975 T8876 themeOf of NFκB,activation of NFκB
R6981 T8978 T8898 themeOf of genes,transcription of genes associated with innate immune responses and inflammation
R6982 T8979 T8878 causeOf glutamate,glutamate receptor activation induced by red blood cells
R6983 T8981 T8893 themeOf of TLR4,the expression of TLR4
R6984 T8982 T8891 causeOf NFκB,of TLR4-mediated NFκB signaling
R6986 T8984 T8878 themeOf receptor,glutamate receptor activation induced by red blood cells
R6987 T8990 T8880 themeOf of TLR4 protein,the expression of TLR4 protein after ICH
R6988 T8992 T8887 themeOf TLR4 in hemorrhagic brain,TLR4 in hemorrhagic brain
R6989 T8994 T8888 themeOf NFκB,NFκB is activated in the brain subjected to ICH
R6991 T9006 T8894 themeOf of TLR4,Our data showed that transcription of TLR4 as well as the expression of TLR4 protein after ICH
R6992 T9008 T8895 themeOf of genes,"transcription of genes associated with immune responses and inflammation [12,"
R2885 T3696 T3704 themeOf The biotinylated secondary antibody,The biotinylated secondary antibody
R3769 T4841 T4843 causeOf the TLR4 mRNA after ICH,the TLR4 mRNA after ICH significantly increased starting from 6 hours after ICH
R6935 T8890 T8897 themeOf "the activation of NFκB [12, 13]","TLR-mediated signaling pathways mainly stimulate the activation of NFκB [12, 13]"
R6942 T8877 T8889 themeOf of TLR4-mediated NFκB signaling,of TLR4-mediated NFκB signaling
R6943 T8883 T8875 themeOf between TLR4-mediated NFκB signaling,between TLR4-mediated NFκB signaling
R6945 T8885 T8884 themeOf increased expression of TLR4,increased expression of TLR4
R6946 T8886 T8892 themeOf TLR4-mediated NFκB signaling,TLR4-mediated NFκB signaling
R6966 T8949 T8883 causeOf NFκB,between TLR4-mediated NFκB signaling

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T384 0-10 NNP denotes Activation
T385 11-13 IN denotes of
T386 14-27 NNP denotes TLR4-Mediated
T387 28-32 NNP denotes NFκB
T388 33-42 VBG denotes Signaling
T389 43-45 IN denotes in
T390 46-57 NNP denotes Hemorrhagic
T391 58-63 NNP denotes Brain
T392 64-66 IN denotes in
T393 67-71 NNP denotes Rats
T2666 5813-5814 . denotes .
T3088 5914-5929 JJ denotes peri-hemorrhage
T8647 18286-18287 . denotes .
T8646 18280-18286 NN denotes damage
T8645 18274-18279 NN denotes brain
T8644 18262-18273 JJ denotes ICH-induced
T8643 18259-18261 IN denotes of
T8642 18248-18258 NN denotes prevention
T8641 18244-18247 DT denotes the
T8640 18240-18243 IN denotes for
T8639 18233-18239 NN denotes target
T8638 18221-18232 JJ denotes therapeutic
T8637 18219-18220 DT denotes a
T8636 18216-18218 VB denotes be
T8635 18212-18215 MD denotes may
T8634 18206-18211 WDT denotes which
T8633 18204-18205 , denotes ,
T8632 18201-18204 NNP denotes ICH
T8631 18198-18200 IN denotes of
T8630 18185-18197 NN denotes pathogenesis
T8629 18181-18184 DT denotes the
T8628 18178-18180 IN denotes in
T8627 18165-18177 VBZ denotes participates
T8626 18155-18164 VBG denotes signaling
T8625 18150-18154 NNP denotes NFκB
T8624 18136-18149 JJ denotes TLR4-mediated
T8623 18131-18135 IN denotes that
T8622 18122-18130 VBZ denotes suggests
T8621 18116-18121 WDT denotes which
T8620 18114-18115 , denotes ,
T8619 18111-18114 NNP denotes ICH
T8618 18098-18110 JJ denotes experimental
T8617 18095-18097 IN denotes of
T8616 18089-18094 NN denotes model
T8615 18085-18088 NN denotes rat
T8614 18083-18084 DT denotes a
T8613 18080-18082 IN denotes in
T8612 18073-18079 NN denotes tissue
T8611 18067-18072 NN denotes brain
T8610 18064-18066 IN denotes in
T8609 18054-18063 VBG denotes signaling
T8608 18049-18053 NNP denotes NFκB
T8607 18035-18048 JJ denotes TLR4-mediated
T8606 18032-18034 IN denotes of
T8605 18021-18031 NN denotes activation
T8604 18017-18020 DT denotes the
T8603 18014-18016 IN denotes of
T8602 18006-18013 NN denotes profile
T8601 17997-18005 JJ denotes temporal
T8600 17993-17996 DT denotes the
T8599 17980-17992 VBD denotes demonstrated
T8598 17974-17979 NN denotes study
T8597 17966-17973 JJ denotes present
T8596 17962-17965 DT denotes the
T8595 17960-17961 , denotes ,
T8594 17950-17960 NN denotes conclusion
T8593 17947-17949 IN denotes In
T8592 17945-17946 . denotes .
T8591 17937-17945 NN denotes research
T8590 17929-17936 JJ denotes further
T8589 17921-17928 IN denotes through
T8588 17910-17920 VBN denotes identified
T8587 17907-17909 VB denotes be
T8586 17904-17906 TO denotes to
T8585 17899-17903 VBP denotes need
T8524 17539-17544 NNS denotes cells
T8523 17533-17538 NN denotes blood
T8522 17530-17532 CC denotes or
T8521 17524-17529 NNS denotes cells
T8520 17515-17523 JJ denotes neuronal
T8519 17507-17514 JJ denotes injured
T8518 17504-17506 IN denotes by
T8517 17495-17503 VBN denotes produced
T8516 17492-17494 VB denotes be
T8515 17488-17491 MD denotes may
T8514 17482-17487 WDT denotes which
T8513 17480-17481 , denotes ,
T8512 17477-17480 NNP denotes ICH
T8511 17471-17476 IN denotes after
T8510 17465-17470 NN denotes brain
T8509 17461-17464 DT denotes the
T8508 17458-17460 IN denotes in
T8507 17446-17457 VBN denotes upregulated
T8506 17443-17445 VB denotes be
T8505 17440-17442 TO denotes to
T8504 17434-17439 VBN denotes found
T8503 17430-17433 VBP denotes are
T8502 17423-17429 NN denotes stress
T8501 17413-17422 JJ denotes oxidative
T8500 17410-17412 IN denotes in
T8499 17401-17409 VBN denotes involved
T8498 17393-17400 VBZ denotes enzymes
T8497 17389-17392 CC denotes and
T8496 17387-17388 , denotes ,
T8495 17382-17387 NNP denotes HSP27
T8494 17380-17381 , denotes ,
T8493 17375-17380 NNP denotes HSP32
T8492 17373-17374 , denotes ,
T8491 17368-17373 NNP denotes HSP70
T8490 17366-17367 , denotes ,
T8489 17358-17366 NN denotes instance
T8488 17354-17357 IN denotes For
T8487 17352-17353 . denotes .
T8486 17340-17352 NN denotes inflammation
T8485 17337-17339 IN denotes by
T8484 17327-17336 VBN denotes activated
T8483 17323-17326 VBP denotes are
T8482 17318-17322 WDT denotes that
T8481 17312-17317 NNS denotes genes
T8480 17309-17311 IN denotes of
T8479 17300-17308 NNS denotes products
T8478 17296-17299 CC denotes and
T8477 17294-17295 , denotes ,
T8476 17289-17294 NNS denotes cells
T8475 17280-17288 VBN denotes ruptured
T8474 17277-17279 IN denotes of
T8473 17266-17276 NNS denotes components
T8472 17252-17265 JJ denotes intracellular
T8471 17250-17251 , denotes ,
T8470 17242-17250 NNS denotes cascades
T8469 17230-17241 JJ denotes proteolytic
T8468 17227-17229 IN denotes of
T8467 17218-17226 NNS denotes products
T8466 17216-17217 , denotes ,
T8465 17202-17216 NNS denotes macromolecules
T8464 17199-17201 IN denotes of
T8463 17190-17198 NNS denotes products
T8462 17178-17189 NN denotes degradation
T8461 17174-17177 DT denotes the
T8460 17171-17173 IN denotes as
T8459 17166-17170 JJ denotes such
T8458 17156-17165 NNS denotes molecules
T8457 17145-17155 JJ denotes endogenous
T8456 17135-17144 VB denotes recognize
T8455 17130-17134 RB denotes also
T8454 17126-17129 MD denotes can
T8453 17122-17125 CC denotes and
T8452 17120-17121 NN denotes ]
T8451 17118-17120 CD denotes 20
T8450 17116-17117 , denotes ,
T8449 17114-17116 CD denotes 19
T8448 17113-17114 NNP denotes [
T8447 17102-17112 NNS denotes components
T8446 17092-17101 JJ denotes microbial
T8445 17089-17091 IN denotes of
T8444 17077-17088 NN denotes recognition
T8443 17073-17076 DT denotes the
T8442 17070-17072 IN denotes in
T8441 17065-17069 NN denotes role
T8440 17055-17064 JJ denotes important
T8439 17052-17054 DT denotes an
T8438 17046-17051 VBZ denotes plays
T8437 17041-17045 CD denotes TLR4
T8436 17039-17040 . denotes .
T8435 17032-17039 NN denotes pathway
T8434 17022-17031 VBG denotes signaling
T8433 17008-17021 JJ denotes TLR4-mediated
T8432 17004-17007 DT denotes the
T8431 16996-17003 IN denotes through
T8430 16986-16995 VBN denotes regulated
T8429 16983-16985 VBZ denotes is
T8428 16978-16982 NNP denotes NFκB
T8427 16975-16977 IN denotes of
T8426 16964-16974 NN denotes activation
T8425 16959-16963 IN denotes that
T8424 16951-16958 NNS denotes reports
T8423 16942-16950 JJ denotes previous
T8422 16937-16941 IN denotes with
T8421 16926-16936 JJ denotes consistent
T8420 16923-16925 VBZ denotes is
T8419 16917-16922 WDT denotes which
T8418 16915-16916 , denotes ,
T8417 16908-16915 NN denotes pathway
T8416 16898-16907 VBG denotes signaling
T8415 16895-16897 NN denotes κB
T8414 16888-16895 CD denotes TLR4/NF
T8413 16884-16887 DT denotes the
T8412 16881-16883 IN denotes of
T8411 16870-16880 NN denotes activation
T8410 16859-16869 VBZ denotes stimulates
T8409 16855-16858 NNP denotes ICH
T8408 16850-16854 IN denotes that
T8407 16842-16849 VBP denotes suggest
T8406 16837-16841 NNS denotes data
T8405 16833-16836 PRP$ denotes Our
T8404 16831-16832 . denotes .
T8403 16827-16831 CD denotes TLR4
T8402 16824-16826 IN denotes of
T8401 16813-16823 NN denotes expression
T8400 16809-16812 DT denotes the
T8399 16806-16808 IN denotes of
T8398 16801-16805 DT denotes that
T8397 16798-16800 TO denotes to
T8396 16790-16797 JJ denotes similar
T8395 16786-16789 VBD denotes was
T8394 16781-16785 NNP denotes NFκB
T8393 16778-16780 IN denotes of
T8392 16767-16777 NN denotes activation
T8391 16763-16766 DT denotes the
T8390 16759-16762 CC denotes and
T8389 16753-16758 NN denotes p-IκB
T8388 16750-16752 IN denotes of
T8387 16739-16749 NN denotes expression
T8386 16735-16738 DT denotes the
T8385 16732-16734 IN denotes of
T8384 16724-16731 NN denotes profile
T8383 16715-16723 JJ denotes temporal
T8382 16711-16714 DT denotes The
T8381 16709-16710 . denotes .
T8380 16706-16709 NNP denotes ICH
T8379 16700-16705 IN denotes after
T8378 16693-16699 NN denotes tissue
T8377 16687-16692 NN denotes brain
T8376 16684-16686 IN denotes in
T8375 16674-16683 VBN denotes increased
T8374 16660-16673 RB denotes significantly
T8373 16655-16659 VBD denotes were
T8372 16650-16654 NNP denotes NFκB
T8371 16647-16649 IN denotes of
T8370 16638-16646 NN denotes activity
T8369 16634-16637 DT denotes the
T8368 16630-16633 CC denotes and
T8367 16626-16629 NNP denotes IκB
T8366 16623-16625 IN denotes of
T8365 16607-16622 NN denotes phosphorylation
T8364 16604-16606 IN denotes of
T8363 16597-16603 NNS denotes levels
T8362 16593-16596 DT denotes the
T8361 16588-16592 IN denotes that
T8360 16579-16587 VBD denotes observed
T8359 16576-16578 PRP denotes We
T8358 16574-16575 . denotes .
T8357 16573-16574 NN denotes ]
T8356 16572-16573 CD denotes 6
T8355 16570-16571 , denotes ,
T8354 16569-16570 CD denotes 5
T8353 16568-16569 NN denotes [
T8352 16555-16567 NN denotes inflammation
T8351 16551-16554 CC denotes and
T8350 16541-16550 NNS denotes responses
T8349 16534-16540 JJ denotes immune
T8348 16527-16533 JJ denotes innate
T8347 16522-16526 IN denotes with
T8346 16511-16521 VBN denotes associated
T8345 16505-16510 NNS denotes genes
T8344 16502-16504 IN denotes of
T8343 16488-16501 NN denotes transcription
T8342 16478-16487 VBZ denotes initiates
T8341 16472-16477 WDT denotes which
T8340 16470-16471 , denotes ,
T8339 16466-16470 NNP denotes NFκB
T8338 16463-16465 IN denotes of
T8337 16449-16462 NN denotes translocation
T8336 16441-16448 JJ denotes nuclear
T8335 16438-16440 IN denotes in
T8334 16428-16437 VBG denotes resulting
T8333 16426-16427 , denotes ,
T8332 16415-16426 NN denotes degradation
T8331 16411-16414 CC denotes and
T8330 16395-16410 NN denotes phosphorylation
T8329 16390-16394 NNP denotes IκBα
T8328 16379-16389 NNS denotes stimulates
T8327 16374-16378 CD denotes TLR4
T8326 16371-16373 IN denotes of
T8325 16360-16370 NNP denotes Activation
T8324 16358-16359 . denotes .
T8323 16351-16358 NN denotes pathway
T8322 16341-16350 VBG denotes signaling
T8321 16327-16340 JJ denotes TLR4-mediated
T8320 16323-16326 DT denotes the
T8319 16320-16322 IN denotes in
T8318 16309-16319 JJ denotes downstream
T8317 16302-16308 NN denotes factor
T8316 16288-16301 NN denotes transcription
T8315 16278-16287 JJ denotes important
T8314 16275-16277 DT denotes an
T8313 16272-16274 VBZ denotes is
T8312 16267-16271 NNP denotes NFκB
T8311 16265-16266 . denotes .
T8310 16259-16265 NNS denotes brains
T8309 16247-16258 JJ denotes hemorrhagic
T8210 15618-15622 IN denotes that
T8209 15608-15617 VBD denotes indicated
T8208 15603-15607 NNS denotes data
T8207 15597-15602 DT denotes These
T8206 15595-15596 . denotes .
T8205 15589-15595 NNS denotes tracts
T8204 15582-15588 NN denotes matter
T8203 15576-15581 JJ denotes white
T8202 15571-15575 DT denotes some
T8201 15567-15570 CC denotes and
T8200 15565-15566 , denotes ,
T8199 15559-15565 NNS denotes nuclei
T8198 15550-15558 JJ denotes thalamic
T8197 15548-15549 , denotes ,
T8196 15542-15548 NN denotes cortex
T8195 15540-15541 , denotes ,
T8194 15529-15540 NN denotes hippocampus
T8193 15525-15528 DT denotes the
T8192 15523-15524 , denotes ,
T8191 15518-15523 NNS denotes areas
T8190 15502-15517 JJ denotes peri-hemorrhage
T8189 15499-15501 IN denotes in
T8188 15487-15498 VBN denotes distributed
T8187 15474-15486 RB denotes consistently
T8186 15470-15473 VBD denotes was
T8185 15468-15469 , denotes ,
T8184 15448-15468 NN denotes immunohistochemistry
T8183 15445-15447 IN denotes by
T8182 15436-15444 VBN denotes detected
T8181 15434-15435 , denotes ,
T8180 15427-15434 NN denotes protein
T8179 15422-15426 CD denotes TLR4
T8178 15418-15421 DT denotes The
T8177 15416-15417 . denotes .
T8176 15407-15416 RB denotes afterward
T8175 15402-15406 NNS denotes days
T8174 15400-15401 CD denotes 7
T8173 15396-15399 IN denotes for
T8172 15390-15395 NN denotes level
T8171 15385-15389 JJ denotes high
T8170 15383-15384 DT denotes a
T8169 15380-15382 IN denotes at
T8168 15369-15379 VBD denotes maintained
T8167 15365-15368 CC denotes and
T8166 15358-15364 NN denotes insult
T8165 15354-15357 NNP denotes ICH
T8164 15350-15353 DT denotes the
T8163 15344-15349 IN denotes after
T8162 15338-15343 NNS denotes hours
T8161 15336-15337 CD denotes 6
T8160 15333-15335 IN denotes as
T8159 15327-15332 JJ denotes early
T8158 15324-15326 RB denotes as
T8157 15316-15323 VBD denotes started
T8156 15308-15315 NNS denotes changes
T8155 15302-15307 DT denotes These
T8154 15300-15301 . denotes .
T8153 15294-15300 NN denotes tissue
T8152 15288-15293 NN denotes brain
T8151 15285-15287 IN denotes in
T8150 15276-15284 VBD denotes elevated
T8149 15262-15275 RB denotes significantly
T8148 15258-15261 NNP denotes ICH
T8147 15252-15257 IN denotes after
T8146 15244-15251 NN denotes protein
T8145 15239-15243 CD denotes TLR4
T8144 15236-15238 IN denotes of
T8143 15225-15235 NN denotes expression
T8142 15221-15224 DT denotes the
T8141 15218-15220 IN denotes as
T8140 15213-15217 RB denotes well
T8139 15210-15212 RB denotes as
T8138 15205-15209 CD denotes TLR4
T8137 15202-15204 IN denotes of
T8136 15188-15201 NN denotes transcription
T8135 15183-15187 IN denotes that
T8134 15176-15182 VBD denotes showed
T8133 15171-15175 NNS denotes data
T8132 15167-15170 PRP$ denotes Our
T8131 15165-15166 . denotes .
T8130 15158-15165 NN denotes protein
T8129 15154-15157 CC denotes and
T8128 15149-15153 NNP denotes mRNA
T8127 15144-15148 CD denotes TLR4
T8126 15140-15143 DT denotes the
T8125 15131-15139 VBD denotes detected
T8124 15127-15130 CC denotes and
T8123 15123-15126 NNP denotes ICH
T8122 15110-15122 JJ denotes experimental
T8121 15107-15109 IN denotes of
T8120 15101-15106 NN denotes model
T8119 15097-15100 NN denotes rat
T8118 15093-15096 DT denotes the
T8117 15081-15092 VBD denotes established
T8116 15078-15080 PRP denotes we
T8115 15076-15077 , denotes ,
T8114 15071-15076 NN denotes study
T8113 15063-15070 JJ denotes present
T8112 15059-15062 DT denotes the
T8111 15056-15058 IN denotes In
T8110 15054-15055 . denotes .
T8109 15051-15054 NNP denotes ICH
T8108 15047-15050 CC denotes and
T8107 15037-15046 VBG denotes signaling
T8106 15032-15036 NNP denotes NFκB
T8105 15018-15031 JJ denotes TLR4-mediated
T8104 15010-15017 IN denotes between
T8103 14997-15009 NN denotes relationship
T8102 14993-14996 DT denotes the
T8101 14989-14992 CC denotes and
T8100 14984-14988 NN denotes role
T8099 14980-14983 DT denotes the
T8098 14968-14979 VB denotes investigate
T8097 14965-14967 TO denotes to
T8096 14956-14964 VBN denotes directed
T8095 14951-14955 VBN denotes been
T8094 14946-14950 VBP denotes have
T8093 14938-14945 NNS denotes studies
T8092 14934-14937 JJ denotes few
T8091 14929-14933 RB denotes very
T8090 14927-14928 , denotes ,
T8089 14926-14927 NNP denotes ]
T8088 14924-14926 CD denotes 17
T8087 14923-14924 NNP denotes [
T8086 14910-14922 NNS denotes constituents
T8085 14903-14909 NN denotes plasma
T8084 14896-14902 CC denotes and/or
T8083 14890-14895 NNS denotes cells
T8082 14884-14889 NN denotes blood
T8081 14880-14883 JJ denotes red
T8080 14877-14879 IN denotes by
T8079 14869-14876 VBN denotes induced
T8078 14858-14868 NN denotes activation
T8077 14849-14857 NN denotes receptor
T8076 14839-14848 NN denotes glutamate
T8075 14836-14838 CC denotes or
T8074 14829-14835 NN denotes stress
T8073 14819-14828 JJ denotes oxidative
T8072 14815-14818 DT denotes the
T8071 14812-14814 TO denotes to
T8070 14801-14811 VBN denotes attributed
T8069 14797-14800 VBD denotes was
T8068 14792-14796 NNP denotes NFκB
T8067 14789-14791 IN denotes of
T8066 14778-14788 NN denotes activation
T8065 14774-14777 DT denotes the
T8064 14769-14773 IN denotes that
T8063 14759-14768 VBD denotes indicated
T8062 14751-14758 NNS denotes reports
T8061 14742-14750 JJ denotes previous
T8060 14733-14741 IN denotes Although
T8059 14731-14732 . denotes .
T8058 14730-14731 NN denotes ]
T8057 14729-14730 CD denotes 8
T8056 14727-14728 , denotes ,
T8055 14726-14727 CD denotes 7
T8054 14725-14726 NN denotes [
T8053 14718-14724 NN denotes injury
T8052 14709-14717 JJ denotes ischemic
T8051 14700-14708 JJ denotes cerebral
T8050 14696-14699 CC denotes and
T8049 14687-14695 NNS denotes diseases
T8048 14683-14686 NNP denotes CNS
T8047 14672-14682 JJ denotes autoimmune
T8584 17895-17898 CC denotes and
T8583 17884-17894 VBN denotes determined
T8582 17879-17883 VBN denotes been
T8581 17875-17878 RB denotes not
T8580 17870-17874 VBP denotes have
T8579 17864-17869 NN denotes brain
T8578 17852-17863 JJ denotes hemorrhagic
T8577 17849-17851 IN denotes in
T8576 17844-17848 CD denotes TLR4
T8575 17840-17843 IN denotes for
T8574 17832-17839 NNS denotes ligands
T8573 17821-17831 JJ denotes endogenous
T8572 17812-17820 JJ denotes specific
T8571 17808-17811 DT denotes the
T8570 17806-17807 , denotes ,
T8569 17799-17806 RB denotes However
T8568 17797-17798 . denotes .
T8567 17792-17797 NN denotes brain
T8566 17788-17791 NNP denotes IHC
T8565 17785-17787 IN denotes in
T8564 17775-17784 NNS denotes responses
T8563 17762-17774 JJ denotes inflammatory
T8562 17758-17761 DT denotes the
T8561 17749-17757 VB denotes initiate
T8560 17745-17748 CC denotes and
T8559 17743-17744 , denotes ,
T8558 17734-17743 VBG denotes signaling
T8557 17729-17733 NNP denotes NFκB
T8556 17715-17728 JJ denotes TLR4-mediated
T8555 17706-17714 VBP denotes activate
T8554 17704-17705 , denotes ,
T8553 17697-17704 NNS denotes ligands
T8552 17692-17696 CD denotes TLR4
T8551 17681-17691 JJ denotes endogenous
T8550 17678-17680 IN denotes as
T8549 17671-17677 NN denotes server
T8548 17664-17670 NN denotes plasma
T8547 17661-17663 IN denotes of
T8546 17648-17660 NNS denotes constituents
T8545 17644-17647 CC denotes and
T8544 17638-17643 NNS denotes cells
T8543 17632-17637 NN denotes blood
T8542 17627-17631 IN denotes from
T8541 17622-17626 VBD denotes came
T8540 17619-17621 CC denotes or
T8539 17613-17618 NN denotes brain
T8538 17605-17612 JJ denotes damaged
T8537 17602-17604 IN denotes in
T8536 17593-17601 VBN denotes produced
T8535 17583-17592 NNS denotes molecules
T8534 17577-17582 DT denotes these
T8533 17572-17576 IN denotes that
T8532 17561-17571 VBN denotes speculated
T8531 17558-17560 VB denotes be
T8530 17554-17557 MD denotes may
T8529 17551-17553 PRP denotes It
T8528 17549-17550 . denotes .
T8527 17548-17549 NNP denotes ]
T8526 17546-17548 CD denotes 21
T8525 17545-17546 NNP denotes [
T8046 14669-14671 CC denotes or
T8045 14656-14668 JJ denotes inflammatory
T8044 14653-14655 IN denotes as
T8043 14648-14652 JJ denotes such
T8042 14646-14647 , denotes ,
T8041 14638-14646 NNS denotes diseases
T8040 14631-14637 NN denotes system
T8039 14629-14630 -RRB- denotes )
T8038 14626-14629 NNP denotes CNS
T8037 14625-14626 -LRB- denotes (
T8036 14617-14624 JJ denotes nervous
T8035 14609-14616 JJ denotes central
T8034 14601-14608 JJ denotes several
T8033 14598-14600 IN denotes in
T8032 14589-14597 VBN denotes involved
T8031 14586-14588 VB denotes be
T8030 14583-14585 TO denotes to
T8029 14574-14582 VBN denotes reported
T8028 14569-14573 VBN denotes been
T8027 14565-14568 VBZ denotes has
T8026 14563-14564 , denotes ,
T8025 14553-14563 VBD denotes recognized
T8024 14549-14552 NNP denotes TLR
T8023 14539-14548 JJ denotes mammalian
T8022 14533-14538 JJ denotes first
T8021 14529-14532 DT denotes the
T8020 14527-14528 , denotes ,
T8019 14523-14527 CD denotes TLR4
T8018 14521-14522 . denotes .
T8017 14520-14521 NN denotes ]
T8016 14518-14520 CD denotes 13
T8015 14516-14517 , denotes ,
T8014 14514-14516 CD denotes 12
T8013 14513-14514 NNP denotes [
T8012 14508-14512 NNP denotes NFκB
T8011 14505-14507 IN denotes of
T8010 14494-14504 NN denotes activation
T8009 14490-14493 DT denotes the
T8008 14480-14489 VBP denotes stimulate
T8007 14473-14479 RB denotes mainly
T8006 14464-14472 NNS denotes pathways
T8005 14454-14463 VBG denotes signaling
T8004 14441-14453 JJ denotes TLR-mediated
T8003 14439-14440 . denotes .
T8002 14438-14439 NNP denotes ]
T8001 14437-14438 CD denotes 4
T8000 14436-14437 NN denotes [
T7999 14427-14435 NN denotes immunity
T7998 14418-14426 JJ denotes adaptive
T7997 14414-14417 CC denotes and
T7996 14407-14413 NN denotes innate
T7995 14404-14406 IN denotes of
T7957 14187-14196 VBN denotes activated
T7956 14184-14186 VBZ denotes is
T7955 14179-14183 NNP denotes NFκB
T7954 14175-14178 WRB denotes how
T7953 14169-14174 IN denotes about
T7952 14159-14168 NN denotes knowledge
T7951 14155-14158 DT denotes The
T7950 14153-14154 . denotes .
T7949 14152-14153 NNP denotes ]
T7948 14150-14152 CD denotes 17
T7903 13892-13903 VBZ denotes contributes
T7902 13888-13891 CC denotes and
T7901 13878-13887 NNS denotes responses
T7900 13865-13877 JJ denotes inflammatory
T7899 13855-13864 VBZ denotes initiates
T7898 13850-13854 NNP denotes NFκB
T7897 13847-13849 IN denotes of
T7896 13836-13846 NNP denotes Activation
T7895 13834-13835 . denotes .
T7894 13833-13834 NNP denotes ]
T7893 13831-13833 CD denotes 15
T7892 13830-13831 NNP denotes [
T7891 13824-13829 NNS denotes genes
T7890 13817-13823 NN denotes target
T7889 13808-13816 VBN denotes selected
T7888 13805-13807 IN denotes of
T7887 13794-13804 NN denotes expression
T7886 13790-13793 DT denotes the
T7885 13785-13789 IN denotes with
T7884 13774-13784 VBN denotes associated
T7883 13771-13773 VBZ denotes is
T7882 13765-13770 WDT denotes which
T7881 13763-13764 , denotes ,
T7880 13760-13763 NNP denotes ICH
T7879 13757-13759 TO denotes to
T7878 13748-13756 NN denotes response
T7877 13745-13747 IN denotes in
T7876 13740-13744 NN denotes week
T7875 13738-13739 DT denotes a
T7874 13732-13737 JJS denotes least
T7873 13729-13731 IN denotes at
T7872 13725-13728 IN denotes for
T7871 13716-13724 VBZ denotes persists
T7870 13712-13715 CC denotes and
T7869 13704-13711 NNS denotes minutes
T7868 13697-13703 IN denotes within
T7867 13690-13696 VBZ denotes occurs
T7866 13679-13689 NN denotes activation
T7865 13674-13678 NNP denotes NFκB
T7864 13672-13673 . denotes .
T7863 13671-13672 NNP denotes ]
T7862 13669-13671 CD denotes 14
T7861 13668-13669 NNP denotes [
T7860 13664-13667 NNP denotes ICH
T7859 13658-13663 IN denotes after
T7858 13645-13657 NN denotes perihematoma
T7857 13642-13644 IN denotes of
T7856 13635-13641 NN denotes region
T7855 13631-13634 DT denotes the
T7854 13628-13630 IN denotes in
T7853 13618-13627 VBD denotes increased
T7852 13613-13617 NNP denotes NFκB
T7851 13608-13612 IN denotes that
T7850 13599-13607 VBN denotes reported
T7849 13594-13598 VBN denotes been
T7848 13590-13593 VBZ denotes has
T7847 13587-13589 PRP denotes It
T7846 13585-13586 . denotes .
T7845 13574-13585 NNS denotes pathologies
T7844 13568-13573 NN denotes brain
T7843 13565-13567 IN denotes in
T7842 13552-13564 NN denotes inflammation
T7841 13541-13551 VBG denotes regulating
T7840 13538-13540 IN denotes in
T7839 13533-13537 NN denotes role
T7838 13529-13532 JJ denotes key
T7837 13527-13528 DT denotes a
T7836 13521-13526 VBZ denotes plays
T7835 13516-13520 RB denotes also
T7834 13512-13515 CC denotes and
T7833 13510-13511 NN denotes ]
T7832 13508-13510 CD denotes 13
T7831 13506-13507 , denotes ,
T7830 13504-13506 CD denotes 12
T7829 13503-13504 NNP denotes [
T7828 13490-13502 NN denotes inflammation
T7827 13486-13489 CC denotes and
T7826 13476-13485 NNS denotes responses
T7825 13469-13475 JJ denotes immune
T7824 13464-13468 IN denotes with
T7823 13453-13463 VBN denotes associated
T7822 13447-13452 NNS denotes genes
T7821 13444-13446 IN denotes of
T7820 13430-13443 NN denotes transcription
T7819 13420-13429 VBZ denotes initiates
T7818 13414-13419 WDT denotes which
T7817 13412-13413 , denotes ,
T7816 13406-13412 NN denotes factor
T7815 13392-13405 NN denotes transcription
T7814 13384-13391 JJ denotes nuclear
T7813 13374-13383 JJ denotes important
T7812 13371-13373 DT denotes an
T7811 13368-13370 VBZ denotes is
T7810 13366-13367 -RRB- denotes )
T7809 13362-13366 NNP denotes NFκB
T7808 13361-13362 -LRB- denotes (
T7807 13346-13360 NNP denotes factor-kappa-B
T7806 13338-13345 JJ denotes nuclear
T7805 13331-13337 NN denotes factor
T7804 13317-13330 NNP denotes Transcription
T7803 13315-13316 . denotes .
T7802 13308-13315 JJ denotes unclear
T7801 13305-13307 VBZ denotes is
T7800 13301-13304 NNP denotes ICH
T7799 13295-13300 IN denotes after
T7798 13288-13294 NN denotes tissue
T7797 13282-13287 NN denotes brain
T7796 13278-13281 DT denotes the
T7795 13275-13277 IN denotes in
T7794 13265-13274 VBN denotes regulated
T8308 16244-16246 IN denotes in
T8307 16239-16243 NNP denotes NFκB
T8306 16236-16238 IN denotes of
T8305 16227-16235 NN denotes activity
T8304 16223-16226 DT denotes the
T8303 16219-16222 CC denotes and
T8302 16213-16218 NN denotes p-IκB
T8301 16209-16212 DT denotes the
T8300 16199-16208 VBG denotes detecting
T8299 16196-16198 IN denotes by
T8298 16186-16195 VBG denotes signaling
T8297 16181-16185 NNP denotes NFκB
T8296 16167-16180 JJ denotes TLR4-mediated
T8295 16164-16166 IN denotes of
T8294 16153-16163 NN denotes activation
T8293 16149-16152 DT denotes the
T8292 16139-16148 VBD denotes evaluated
T8291 16136-16138 PRP denotes we
T8290 16134-16135 , denotes ,
T8289 16129-16134 NN denotes study
T8288 16121-16128 JJ denotes present
T8287 16117-16120 DT denotes the
T8286 16114-16116 IN denotes in
T8285 16112-16113 , denotes ,
T8284 16109-16112 NNP denotes ICH
T8283 16103-16108 IN denotes after
T8282 16097-16102 NN denotes brain
T8281 16093-16096 DT denotes the
T8280 16090-16092 IN denotes in
T8279 16080-16089 NNS denotes responses
T8278 16067-16079 JJ denotes inflammatory
T8277 16057-16066 VBN denotes increased
T8276 16053-16056 DT denotes the
T8275 16042-16052 VBG denotes underlying
T8274 16031-16041 NNS denotes mechanisms
T8273 16027-16030 DT denotes the
T8272 16015-16026 VB denotes investigate
T8271 16012-16014 TO denotes To
T8270 16010-16011 . denotes .
T8269 16001-16010 NNS denotes responses
T8268 15988-16000 JJ denotes inflammatory
T8267 15984-15987 CC denotes and
T8266 15970-15983 JJ denotes immunological
T8265 15960-15969 VBZ denotes regulates
T8264 15956-15959 CC denotes and
T8263 15946-15955 NNS denotes activates
T8262 15938-15945 NN denotes pathway
T8261 15919-15937 JJ denotes TLR4-mediated-NFκB
T8260 15914-15918 IN denotes that
T8259 15905-15913 VBN denotes believed
T8258 15901-15904 RB denotes now
T8257 15898-15900 VBZ denotes is
T8256 15895-15897 PRP denotes It
T8255 15893-15894 . denotes .
T8254 15892-15893 NNP denotes ]
T8253 15890-15892 CD denotes 18
T8252 15889-15890 NNP denotes [
T8251 15883-15888 NN denotes death
T8250 15878-15882 NN denotes cell
T8249 15874-15877 CC denotes and
T8248 15863-15873 NN denotes hemorrhage
T8247 15860-15862 IN denotes of
T8246 15853-15859 NN denotes growth
T8245 15843-15852 JJ denotes secondary
T8244 15838-15842 IN denotes with
T8243 15827-15837 VBN denotes associated
T8242 15823-15826 VBP denotes are
T8241 15817-15822 WDT denotes which
T8240 15815-15816 , denotes ,
T8239 15806-15815 NNS denotes responses
T8238 15793-15805 JJ denotes inflammatory
T8237 15783-15792 VBZ denotes initiates
T8236 15779-15782 NNP denotes ICH
T8235 15774-15778 IN denotes that
T8234 15761-15773 VBD denotes demonstrated
T8233 15753-15760 NNS denotes studies
T8232 15746-15752 JJ denotes Recent
T8231 15744-15745 . denotes .
T8230 15741-15744 NNP denotes ICH
T8229 15735-15740 IN denotes after
T8228 15728-15734 NN denotes tissue
T8227 15722-15727 NN denotes brain
T8226 15718-15721 DT denotes the
T8225 15715-15717 IN denotes in
T8224 15705-15714 NNS denotes responses
T8223 15692-15704 JJ denotes inflammatory
T8222 15688-15691 DT denotes the
T8221 15685-15687 IN denotes of
T8220 15674-15684 VBG denotes triggering
T8219 15670-15673 DT denotes the
T8218 15667-15669 TO denotes to
T8217 15659-15666 VBN denotes related
T8216 15656-15658 VB denotes be
T8215 15652-15655 MD denotes may
T8214 15647-15651 CD denotes TLR4
T8213 15644-15646 IN denotes of
T8212 15633-15643 NN denotes expression
T8211 15623-15632 VBN denotes increased
T7793 13261-13264 CC denotes and
T7792 13251-13260 VBN denotes activated
T7791 13248-13250 VBZ denotes is
T7790 13238-13247 NNS denotes responses
T7789 13225-13237 JJ denotes inflammatory
T7788 13221-13224 DT denotes the
T7787 13217-13220 WRB denotes how
T7786 13215-13216 , denotes ,
T7785 13208-13215 RB denotes However
T7784 13206-13207 . denotes .
T7783 13203-13206 NNP denotes ICH
T7782 13200-13202 IN denotes of
T7781 13187-13199 NN denotes pathogenesis
T7780 13183-13186 DT denotes the
T7779 13180-13182 IN denotes in
T7778 13170-13179 JJ denotes important
T7777 13167-13169 VB denotes be
T7776 13163-13166 MD denotes may
T7775 13161-13162 , denotes ,
T7774 13151-13161 VBP denotes complement
T7773 13147-13150 CC denotes and
T7772 13145-13146 , denotes ,
T7771 13130-13145 NNS denotes immunoglobulins
T7770 13128-13129 , denotes ,
T7769 13118-13128 NNS denotes leukocytes
T7768 13116-13117 , denotes ,
T7767 13107-13116 NNS denotes cytokines
T7766 13105-13106 , denotes ,
T7765 13096-13105 NNS denotes molecules
T7764 13087-13095 NN denotes adhesion
T7763 13077-13086 VBG denotes including
T7762 13075-13076 , denotes ,
T7761 13067-13075 NN denotes response
T7760 13054-13066 JJ denotes inflammatory
T7759 13050-13053 DT denotes the
T7758 13047-13049 IN denotes of
T7757 13034-13046 NNS denotes constituents
T7756 13026-13033 JJ denotes Various
T7755 13024-13025 . denotes .
T7754 13021-13024 NNP denotes ICH
T7753 13017-13020 IN denotes for
T7752 13009-13016 NNS denotes targets
T7751 12997-13008 JJ denotes therapeutic
T7750 12993-12996 JJ denotes new
T7749 12985-12992 VB denotes provide
T7748 12979-12984 MD denotes could
T7747 12973-12978 WDT denotes which
T7746 12971-12972 , denotes ,
T7745 12965-12971 NN denotes injury
T7744 12959-12964 NN denotes brain
T7743 12951-12958 VBD denotes induced
T7742 12947-12950 NNP denotes ICH
T7994 14394-14403 NN denotes induction
T7993 14390-14393 DT denotes the
T7992 14387-14389 IN denotes in
T7991 14382-14386 NN denotes role
T7990 14373-14381 JJ denotes critical
T7989 14371-14372 DT denotes a
T7988 14366-14370 VB denotes play
T7987 14362-14365 CC denotes and
T7986 14352-14361 NNS denotes molecules
T7985 14339-14351 NN denotes transduction
T7984 14332-14338 NN denotes signal
T7983 14329-14331 IN denotes of
T7982 14322-14328 NN denotes family
T7981 14320-14321 DT denotes a
T7980 14316-14319 VBP denotes are
T7979 14314-14315 -RRB- denotes )
T7978 14310-14314 NNS denotes TLRs
T7977 14309-14310 -LRB- denotes (
T7976 14299-14308 NNS denotes receptors
T7975 14289-14298 JJ denotes Toll-like
T7974 14287-14288 . denotes .
T7973 14284-14287 NNP denotes ICH
T7972 14280-14283 IN denotes for
T7971 14273-14279 NN denotes method
T7970 14257-14272 JJ denotes neuroprotective
T7969 14253-14256 JJ denotes new
T7968 14251-14252 DT denotes a
T7967 14243-14250 VBG denotes seeking
T7966 14239-14242 IN denotes for
T7965 14230-14238 JJ denotes critical
T7964 14227-14229 VBZ denotes is
T7963 14223-14226 NNP denotes ICH
T7962 14220-14222 TO denotes to
T7961 14210-14219 VBN denotes subjected
T7960 14204-14209 NN denotes brain
T7959 14200-14203 DT denotes the
T7958 14197-14199 IN denotes in
T7726 12859-12868 VBG denotes producing
T7725 12856-12858 IN denotes of
T7724 12848-12855 JJ denotes capable
T7723 12843-12847 RB denotes also
T7722 12839-12842 VBP denotes are
T7721 12832-12838 PRP denotes itself
T7720 12826-12831 NNS denotes cells
T7719 12820-12825 NN denotes brain
T7718 12816-12819 DT denotes the
T7717 12812-12815 CC denotes and
T7716 12803-12811 NN denotes reaction
T7715 12790-12802 JJ denotes inflammatory
T7714 12787-12789 DT denotes an
T7713 12780-12786 VB denotes induce
T7712 12776-12779 CC denotes and
T7711 12770-12775 NN denotes brain
T7710 12766-12769 DT denotes the
T7709 12763-12765 TO denotes to
T7708 12757-12762 VB denotes enter
T7707 12751-12756 MD denotes might
T7706 12745-12750 NN denotes blood
T7705 12741-12744 DT denotes the
T7704 12736-12740 IN denotes from
T7703 12726-12735 NNS denotes mediators
T7702 12713-12725 JJ denotes inflammatory
T7701 12711-12712 , denotes ,
T7700 12708-12711 NNP denotes ICH
T7699 12702-12707 IN denotes After
T7698 12700-12701 . denotes .
T7697 12694-12700 NNS denotes events
T7696 12678-12693 JJ denotes cerebrovascular
T7695 12675-12677 IN denotes in
T7694 12666-12674 VBN denotes involved
T7693 12662-12665 VBP denotes are
T7692 12652-12661 NNS denotes processes
T7691 12639-12651 JJ denotes inflammatory
T7690 12634-12638 IN denotes that
T7689 12625-12633 NN denotes evidence
T7688 12614-12624 VBG denotes increasing
T7687 12611-12613 VBZ denotes is
T7686 12605-12610 EX denotes there
T7685 12603-12604 , denotes ,
T7684 12595-12603 NN denotes addition
T7683 12592-12594 IN denotes In
T7682 12590-12591 . denotes .
T7681 12584-12590 NN denotes damage
T7680 12577-12583 NN denotes tissue
T7679 12571-12576 NN denotes brain
T7678 12564-12570 VB denotes induce
T7677 12560-12563 NNP denotes ICH
T7676 12554-12559 IN denotes after
T7675 12543-12553 NNS denotes components
T7674 12537-12542 NN denotes blood
T7673 12534-12536 IN denotes of
T7672 12525-12533 NN denotes toxicity
T7671 12521-12524 CC denotes and
T7670 12519-12520 , denotes ,
T7669 12511-12519 NN denotes ischemia
T7668 12509-12510 , denotes ,
T7667 12503-12509 NN denotes effect
T7666 12498-12502 NNP denotes Mass
T7665 12496-12497 . denotes .
T7664 12487-12496 JJ denotes effective
T7663 12483-12486 RB denotes not
T7662 12479-12482 VBP denotes are
T7661 12475-12478 NNP denotes ICH
T7660 12469-12474 IN denotes after
T7659 12462-12468 NN denotes tissue
T7658 12456-12461 NN denotes brain
T7657 12452-12455 DT denotes the
T7656 12449-12451 IN denotes of
T7655 12438-12448 NN denotes protection
T7654 12434-12437 CC denotes and
T7653 12426-12433 NN denotes disease
T7652 12421-12425 DT denotes this
T7651 12418-12420 IN denotes of
T7650 12408-12417 NN denotes treatment
T7649 12404-12407 IN denotes for
T7648 12397-12403 NN denotes method
T7647 12393-12396 DT denotes the
T7646 12391-12392 , denotes ,
T7645 12378-12391 RB denotes Unfortunately
T7644 12376-12377 . denotes .
T7643 12375-12376 NNP denotes ]
T7642 12373-12375 CD denotes 10
T7641 12372-12373 NNP denotes [
T7640 12367-12371 NN denotes year
T7639 12363-12366 CD denotes 1st
T7638 12359-12362 DT denotes the
T7637 12351-12358 VBP denotes survive
T7636 12342-12350 NNS denotes patients
T7635 12338-12341 DT denotes the
T7634 12335-12337 IN denotes of
T7633 12333-12334 NN denotes %
T7632 12331-12333 CD denotes 38
T7631 12326-12330 RB denotes Only
T7630 12324-12325 . denotes .
T7629 12318-12324 NNS denotes months
T7628 12316-12317 CD denotes 3
T7627 12313-12315 IN denotes at
T7626 12301-12312 JJ denotes independent
T7625 12288-12300 RB denotes functionally
T7624 12284-12287 VBP denotes are
T7623 12282-12283 NN denotes %
T7622 12280-12282 CD denotes 31
T7621 12275-12279 RB denotes Only
T7620 12273-12274 . denotes .
T7619 12267-12273 NN denotes stroke
T7618 12258-12266 JJ denotes ischemic
T7617 12255-12257 IN denotes of
T7616 12250-12254 DT denotes that
T7615 12245-12249 IN denotes than
T7614 12238-12244 JJR denotes higher
T7613 12235-12237 VBZ denotes is
T7612 12231-12234 NNP denotes ICH
T7611 12228-12230 IN denotes of
T7610 12218-12227 NN denotes mortality
T7609 12214-12217 DT denotes The
T7608 12212-12213 . denotes .
T7607 12211-12212 NNP denotes ]
T7606 12210-12211 CD denotes 1
T7605 12209-12210 NNP denotes [
T7604 12202-12208 NN denotes stroke
T7603 12193-12201 JJ denotes ischemic
T7602 12190-12192 IN denotes of
T7601 12180-12189 NN denotes treatment
T7600 12167-12179 JJ denotes thrombolytic
T7599 12163-12166 DT denotes the
T7598 12160-12162 IN denotes of
T7597 12147-12159 NN denotes complication
T7596 12145-12146 DT denotes a
T7595 12142-12144 IN denotes as
T7594 12132-12141 NN denotes frequency
T7593 12121-12131 VBG denotes increasing
T7592 12116-12120 IN denotes with
T7591 12109-12115 VBZ denotes occurs
T7590 12105-12108 CC denotes and
T7589 12103-12104 , denotes ,
T7588 12096-12103 NNS denotes strokes
T7587 12092-12095 DT denotes all
T7586 12089-12091 IN denotes of
T7585 12087-12088 NN denotes %
T7584 12085-12087 CD denotes 15
T7583 12082-12084 CD denotes 10
T7582 12071-12081 VBZ denotes represents
T7581 12069-12070 -RRB- denotes )
T7580 12066-12069 NNP denotes ICH
T7579 12065-12066 -LRB- denotes (
T7578 12054-12064 NN denotes hemorrhage
T7577 12039-12053 JJ denotes Intra-cerebral
T7741 12943-12946 DT denotes the
T7740 12939-12942 IN denotes for
T7739 12927-12938 JJ denotes responsible
T7738 12923-12926 VBP denotes are
T7737 12913-12922 NNS denotes responses
T7736 12900-12912 JJ denotes inflammatory
T7735 12896-12899 DT denotes The
T7734 12894-12895 . denotes .
T7733 12893-12894 NNP denotes ]
T7732 12891-12893 CD denotes 11
T7731 12890-12891 NNP denotes [
T7730 12883-12889 NNS denotes agents
T7729 12877-12882 DT denotes these
T7728 12874-12876 IN denotes of
T7727 12869-12873 JJ denotes many
T5955 12022-12023 . denotes .
T5954 12021-12022 -RRB- denotes )
T5953 12020-12021 CD denotes 4
T5952 12013-12019 NN denotes Figure
T5951 12012-12013 -LRB- denotes (
T5950 12006-12011 NN denotes p-IκB
T5949 12002-12005 DT denotes the
T5948 11999-12001 IN denotes of
T5947 11994-11998 DT denotes that
T5946 11991-11993 IN denotes as
T5945 11984-11990 NN denotes manner
T5944 11979-11983 JJ denotes same
T5943 11975-11978 DT denotes the
T5942 11972-11974 IN denotes in
T5941 11962-11971 VBN denotes increased
T5940 11957-11961 RB denotes also
T5939 11953-11956 VBD denotes was
T5938 11948-11952 NNP denotes NFκB
T5937 11945-11947 IN denotes of
T5936 11936-11944 NN denotes activity
T5935 11932-11935 DT denotes the
T5934 11930-11931 , denotes ,
T5933 11922-11930 VBN denotes expected
T5932 11919-11921 IN denotes As
T5931 11917-11918 . denotes .
T5930 11916-11917 -RRB- denotes )
T5929 11915-11916 CD denotes 5
T5928 11908-11914 NN denotes Figure
T5927 11906-11907 , denotes ,
T5926 11903-11906 CD denotes .05
T5925 11901-11902 CD denotes <
T5924 11899-11900 NNP denotes P
T5923 11898-11899 -LRB- denotes (
T5922 11894-11897 NNP denotes ICH
T5921 11888-11893 IN denotes after
T5920 11883-11887 NNS denotes days
T5919 11881-11882 CD denotes 7
T5918 11878-11880 IN denotes on
T5917 11872-11877 NN denotes level
T5916 11867-11871 JJ denotes high
T5915 11865-11866 DT denotes a
T5914 11854-11864 VBD denotes maintained
T5913 11850-11853 CC denotes and
T5912 11848-11849 , denotes ,
T5911 11845-11848 NNP denotes ICH
T5910 11839-11844 IN denotes after
T5909 11834-11838 NNS denotes days
T5908 11832-11833 CD denotes 3
T5907 11829-11831 IN denotes on
T5906 11822-11828 VBD denotes peaked
T5905 11820-11821 , denotes ,
T5904 11819-11820 -RRB- denotes )
T5903 11816-11819 CD denotes .05
T5902 11814-11815 CD denotes <
T5901 11812-11813 NNP denotes P
T5900 11811-11812 -LRB- denotes (
T5899 11807-11810 NNP denotes ICH
T5898 11801-11806 IN denotes after
T5897 11795-11800 NNS denotes hours
T5896 11793-11794 CD denotes 6
T5895 11790-11792 IN denotes at
T5894 11780-11789 VBD denotes increased
T5893 11774-11779 NN denotes p-IκB
T5892 11770-11773 DT denotes the
T5891 11765-11769 IN denotes that
T5890 11758-11764 VBD denotes showed
T5889 11750-11757 NNS denotes Results
T5888 11748-11749 . denotes .
T5887 11744-11748 NNP denotes EMSA
T5886 11740-11743 CC denotes and
T5885 11734-11739 NNS denotes Blots
T5884 11726-11733 JJ denotes Western
T5883 11723-11725 IN denotes of
T5882 11715-11722 NNS denotes methods
T5881 11712-11714 IN denotes by
T5880 11703-11711 VBN denotes measured
T5879 11698-11702 VBD denotes were
T5878 11693-11697 NNP denotes NFκB
T5877 11690-11692 IN denotes of
T5876 11681-11689 NN denotes activity
T5875 11677-11680 CC denotes and
T5874 11675-11676 -RRB- denotes )
T5873 11670-11675 NNP denotes p-IκB
T5872 11669-11670 -LRB- denotes (
T5871 11661-11668 NNP denotes kappa-B
T5870 11658-11660 IN denotes of
T5869 11648-11657 NN denotes inhibitor
T5868 11645-11647 IN denotes of
T5867 11629-11644 NN denotes phosphorylation
T5866 11625-11628 DT denotes the
T5865 11623-11624 , denotes ,
T5864 11614-11623 VBG denotes signaling
T5863 11609-11613 NNP denotes NFκB
T5862 11595-11608 JJ denotes TLR4-mediated
T5861 11592-11594 IN denotes of
T5860 11581-11591 NN denotes activation
T5859 11577-11580 DT denotes the
T5858 11569-11576 VB denotes detectd
T5857 11566-11568 TO denotes To
T5856 11564-11565 . denotes .
T5855 11555-11564 NNS denotes responses
T5854 11542-11554 JJ denotes inflammatory
T5853 11539-11541 TO denotes to
T5852 11531-11538 VBN denotes related
T5851 11525-11530 NNS denotes genes
T5850 11522-11524 IN denotes of
T5849 11508-11521 NN denotes transcription
T5848 11504-11507 DT denotes the
T5847 11494-11503 VBZ denotes regulates
T5846 11490-11493 CC denotes and
T5845 11480-11489 NNS denotes activates
T5844 11476-11479 CC denotes and
T5843 11468-11475 NN denotes nucleus
T5842 11464-11467 DT denotes the
T5841 11459-11463 IN denotes into
T5840 11446-11458 VBZ denotes translocates
T5839 11441-11445 NNP denotes NFκB
T5838 11439-11440 , denotes ,
T5837 11435-11439 RB denotes Then
T5836 11433-11434 . denotes .
T5835 11432-11433 -RRB- denotes )
T5834 11428-11432 NNP denotes NFκB
T5833 11427-11428 -LRB- denotes (
T5832 11416-11426 NNP denotes NF-kappa-B
T5831 11411-11415 IN denotes with
T5830 11407-11410 NNP denotes IκB
T5829 11395-11406 VBZ denotes dissociates
T5828 11389-11394 WDT denotes which
T5827 11387-11388 , denotes ,
T5826 11386-11387 -RRB- denotes )
T5825 11383-11386 NNP denotes IκB
T5824 11382-11383 -LRB- denotes (
T5823 11374-11381 NNP denotes kappa-B
T5822 11371-11373 IN denotes of
T5821 11361-11370 NN denotes inhibitor
T5820 11358-11360 IN denotes of
T5819 11342-11357 NN denotes phosphorylation
T5818 11338-11341 DT denotes the
T5536 11254-11255 . denotes .
T5535 11253-11254 -RRB- denotes )
T5534 11252-11253 CD denotes 3
T5533 11245-11251 NN denotes Figure
T5532 11244-11245 -LRB- denotes (
T5531 11237-11243 NNS denotes tracts
T5530 11230-11236 NN denotes matter
T5529 11224-11229 JJ denotes white
T5817 11330-11337 VBZ denotes induces
T5816 11325-11329 CD denotes TLR4
T5815 11322-11324 IN denotes of
T5814 11311-11321 NNP denotes Activation
T5813 11301-11310 NNP denotes Signaling
T5812 11290-11300 NNP denotes NF-Kappa-B
T5811 11276-11289 NNP denotes TLR4-Mediated
T5810 11273-11275 IN denotes of
T5809 11262-11272 NNP denotes Activation
T5808 11260-11261 . denotes .
T5807 11257-11260 CD denotes 3.4
T5213 10822-10823 . denotes .
T5212 10819-10822 NNP denotes ICH
T5211 10813-10818 IN denotes after
T5210 10808-10812 NNP denotes mRNA
T5209 10803-10807 CD denotes TLR4
T5208 10799-10802 DT denotes the
T5207 10796-10798 IN denotes of
T5206 10788-10795 NN denotes profile
T5205 10779-10787 JJ denotes temporal
T5204 10775-10778 DT denotes the
T5203 10770-10774 IN denotes with
T5202 10759-10769 JJ denotes consistent
T5201 10755-10758 VBD denotes was
T5200 10747-10754 NN denotes protein
T5199 10742-10746 CD denotes TLR4
T5198 10739-10741 IN denotes of
T5197 10727-10738 NN denotes observation
T5196 10722-10726 DT denotes This
T5195 10720-10721 . denotes .
T5194 10719-10720 -RRB- denotes )
T5193 10718-10719 CD denotes 2
T5192 10711-10717 NN denotes Figure
T5191 10709-10710 , denotes ,
T5190 10706-10709 CD denotes .05
T5189 10704-10705 CD denotes <
T5188 10702-10703 NNP denotes P
T5187 10701-10702 -LRB- denotes (
T5186 10697-10700 NNP denotes ICH
T5185 10691-10696 IN denotes after
T5184 10687-10690 NN denotes day
T5183 10683-10686 JJ denotes 7th
T5182 10679-10682 DT denotes the
T5181 10676-10678 IN denotes on
T5180 10670-10675 NN denotes level
T5179 10665-10669 JJ denotes high
T5178 10663-10664 DT denotes a
T5177 10660-10662 IN denotes at
T5176 10649-10659 VBN denotes maintained
T5175 10643-10648 RB denotes still
T5174 10639-10642 CC denotes but
T5173 10629-10638 VBD denotes decreased
T5172 10624-10628 RB denotes then
T5171 10620-10623 CC denotes and
T5170 10618-10619 , denotes ,
T5169 10615-10618 NNP denotes ICH
T5168 10609-10614 IN denotes after
T5153 10558-10559 CD denotes 6
T5152 10553-10557 IN denotes from
T5151 10544-10552 VBG denotes starting
T5150 10534-10543 VBD denotes increased
T5149 10520-10533 RB denotes significantly
T5148 10515-10519 CD denotes TLR4
T5147 10512-10514 IN denotes of
T5146 10501-10511 NN denotes expression
T5145 10497-10500 DT denotes The
T5144 10495-10496 . denotes .
T5143 10490-10495 NN denotes group
T5142 10482-10489 NN denotes control
T5141 10475-10481 NN denotes saline
T5140 10471-10474 DT denotes the
T5139 10468-10470 IN denotes in
T5138 10457-10467 JJ denotes detectable
T5137 10453-10456 VBD denotes was
T5136 10445-10452 NN denotes protein
T5135 10440-10444 CD denotes TLR4
T5134 10437-10439 IN denotes of
T5133 10431-10436 NN denotes level
T5132 10427-10430 JJ denotes low
T5131 10425-10426 DT denotes a
T5130 10420-10424 IN denotes that
T5129 10413-10419 VBD denotes showed
T5128 10405-10412 NNS denotes results
T5127 10401-10404 PRP$ denotes Our
T5126 10399-10400 . denotes .
T5125 10395-10399 CD denotes TLR4
T5124 10391-10394 IN denotes for
T5123 10380-10390 NNS denotes antibodies
T5122 10371-10379 JJ denotes specific
T5121 10365-10370 VBG denotes using
T5120 10359-10364 NNS denotes Blots
T5119 10351-10358 JJ denotes Western
T5118 10348-10350 IN denotes of
T5117 10341-10347 NN denotes method
T5116 10337-10340 DT denotes the
T5115 10334-10336 IN denotes by
T5114 10327-10333 NN denotes tissue
T5113 10321-10326 NN denotes brain
T5112 10318-10320 IN denotes in
T5111 10309-10317 VBN denotes measured
T5110 10305-10308 VBD denotes was
T5109 10297-10304 NN denotes protein
T5108 10292-10296 CD denotes TLR4
T5107 10289-10291 IN denotes of
T5106 10278-10288 NN denotes expression
T5105 10274-10277 DT denotes the
T5104 10272-10273 , denotes ,
T5103 10267-10272 NN denotes level
T5102 10259-10266 NN denotes protein
T5101 10255-10258 DT denotes the
T5100 10252-10254 IN denotes at
T5099 10247-10251 CD denotes TLR4
T5098 10237-10246 VBN denotes increased
T5097 10233-10236 DT denotes the
T5096 10221-10232 VB denotes investigate
T5095 10218-10220 TO denotes To
T5094 10214-10217 NNP denotes ICH
T5093 10208-10213 IN denotes after
T5092 10201-10207 NNP denotes Tissue
T5091 10195-10200 NNP denotes Brain
T5090 10192-10194 IN denotes in
T5089 10182-10191 VBN denotes Increased
T5088 10174-10181 NNP denotes Protein
T5087 10169-10173 CD denotes TLR4
T5086 10166-10168 IN denotes of
T5085 10155-10165 NN denotes Expression
T5084 10153-10154 . denotes .
T5528 11219-11223 DT denotes some
T5527 11215-11218 CC denotes and
T5526 11213-11214 , denotes ,
T5525 11207-11213 NNS denotes nuclei
T5524 11198-11206 JJ denotes thalamic
T5523 11196-11197 , denotes ,
T5522 11190-11196 NN denotes cortex
T5521 11188-11189 , denotes ,
T5520 11177-11188 NN denotes hippocampus
T5519 11173-11176 DT denotes the
T5518 11171-11172 , denotes ,
T5517 11166-11171 NNS denotes areas
T5516 11150-11165 JJ denotes peri-hemorrhage
T5515 11147-11149 IN denotes in
T5514 11134-11146 VBN denotes demonstrated
T5513 11121-11133 RB denotes consistently
T5512 11117-11120 VBD denotes was
T5511 11112-11116 CD denotes TLR4
T5510 11108-11111 IN denotes for
T5509 11091-11107 NN denotes immunoreactivity
T5508 11089-11090 , denotes ,
T5507 11082-11089 RB denotes However
T5506 11080-11081 . denotes .
T5505 11073-11080 NN denotes control
T5504 11068-11072 JJ denotes sham
T5503 11064-11067 CC denotes and
T5502 11057-11063 JJ denotes normal
T5501 11052-11056 IN denotes from
T5500 11045-11051 NN denotes tissue
T5499 11039-11044 NN denotes brain
T5498 11036-11038 IN denotes in
T5497 11025-11035 JJ denotes detectable
T5496 11021-11024 RB denotes not
T5495 11017-11020 VBD denotes was
T5494 11000-11016 NN denotes immunoreactivity
T5493 10995-10999 CD denotes TLR4
T5492 10990-10994 IN denotes that
T5491 10983-10989 VBD denotes showed
T5490 10975-10982 NNS denotes Results
T5489 10973-10974 . denotes .
T5488 10972-10973 -RRB- denotes )
T5487 10969-10972 NNP denotes IHC
T5486 10968-10969 -LRB- denotes (
T5485 10947-10967 NN denotes immunohistochemistry
T5484 10944-10946 IN denotes by
T5483 10935-10943 VBN denotes detected
T5482 10931-10934 VBD denotes was
T5481 10926-10930 NNP denotes TLR4
T5480 10922-10925 DT denotes the
T5479 10920-10921 , denotes ,
T5478 10913-10920 NN denotes protein
T5477 10908-10912 CD denotes TLR4
T5476 10905-10907 IN denotes of
T5475 10892-10904 NN denotes distribution
T5474 10888-10891 DT denotes the
T5473 10880-10887 VB denotes explore
T5472 10877-10879 TO denotes To
T5471 10873-10876 NNP denotes ICH
T5470 10870-10872 TO denotes to
T5469 10860-10869 NNP denotes Subjected
T5468 10854-10859 NNP denotes Brain
T5467 10851-10853 IN denotes in
T5466 10846-10850 CD denotes TLR4
T5465 10843-10845 IN denotes of
T5464 10830-10842 NN denotes Distribution
T5463 10828-10829 . denotes .
T5462 10825-10828 CD denotes 3.3
T4768 10147-10148 . denotes .
T4767 10146-10147 -RRB- denotes )
T4766 10145-10146 CD denotes 1
T4765 10138-10144 NNP denotes Figure
T4764 10136-10137 , denotes ,
T4763 10133-10136 CD denotes .05
T4762 10131-10132 CD denotes <
T4761 10129-10130 NNP denotes P
T4760 10128-10129 -LRB- denotes (
T4759 10120-10127 NN denotes control
T4758 10113-10119 NN denotes saline
T4757 10108-10112 IN denotes with
T4756 10099-10107 VBN denotes compared
T4755 10093-10098 NN denotes level
T4754 10086-10092 JJR denotes higher
T4753 10084-10085 DT denotes a
T4752 10073-10083 VBD denotes maintained
T4751 10067-10072 RB denotes still
T4750 10063-10066 CC denotes but
T4749 10061-10062 , denotes ,
T4748 10060-10061 -RRB- denotes )
T4747 10057-10060 CD denotes .05
T4746 10055-10056 CD denotes <
T4745 10053-10054 NNP denotes P
T4744 10052-10053 -LRB- denotes (
T4743 10048-10051 NNP denotes ICH
T4742 10042-10047 IN denotes after
T4741 10038-10041 NN denotes day
T4740 10034-10037 JJ denotes 7th
T4739 10030-10033 DT denotes the
T4738 10027-10029 IN denotes on
T4737 10017-10026 VBD denotes decreased
T4736 10012-10016 RB denotes then
T4735 10008-10011 CC denotes and
T4734 10006-10007 , denotes ,
T4733 10003-10006 NNP denotes ICH
T4732 9997-10002 IN denotes after
T4731 9993-9996 NN denotes day
T4730 9989-9992 JJ denotes 3rd
T4729 9985-9988 DT denotes the
T4728 9982-9984 IN denotes on
T4727 9975-9981 VBD denotes peaked
T4726 9973-9974 , denotes ,
T4725 9972-9973 -RRB- denotes )
T4724 9969-9972 CD denotes .05
T4723 9967-9968 CD denotes <
T4722 9965-9966 NNP denotes P
T4721 9964-9965 -LRB- denotes (
T4720 9960-9963 NNP denotes ICH
T4719 9954-9959 IN denotes after
T4718 9948-9953 NNS denotes hours
T4717 9946-9947 CD denotes 6
T4716 9941-9945 IN denotes from
T4715 9932-9940 VBG denotes starting
T4714 9922-9931 VBD denotes increased
T4470 9581-9582 . denotes .
T4469 9569-9581 NN denotes significance
T4468 9566-9568 IN denotes of
T4467 9557-9565 NNS denotes criteria
T4466 9553-9556 DT denotes the
T4465 9550-9552 IN denotes as
T4464 9545-9549 VBN denotes used
T4463 9541-9544 VBD denotes was
T4462 9529-9540 NN denotes probability
T4461 9526-9528 IN denotes of
T4460 9520-9525 NN denotes level
T4459 9516-9519 CD denotes .05
T4458 9514-9515 NN denotes <
T4457 9512-9513 NNP denotes P
T4456 9508-9511 DT denotes The
T4455 9506-9507 . denotes .
T4454 9500-9506 JJS denotes t-test
T4453 9497-9499 POS denotes 's
T4452 9490-9497 NN denotes Student
T4451 9487-9489 CC denotes or
T4450 9485-9486 -RRB- denotes )
T4449 9480-9485 NNP denotes ANOVA
T4448 9479-9480 -LRB- denotes (
T4447 9470-9478 NN denotes variance
T4446 9467-9469 IN denotes of
T4445 9458-9466 NN denotes analysis
T4444 9450-9457 JJ denotes one-way
T4443 9447-9449 IN denotes by
T4442 9438-9446 VBN denotes analyzed
T4441 9433-9437 VBD denotes were
T4440 9420-9432 NNS denotes measurements
T4439 9416-9419 DT denotes The
T4438 9414-9415 . denotes .
T4437 9411-9414 NNP denotes SEM
T4436 9409-9410 NN denotes ±
T4435 9404-9408 JJ denotes mean
T4434 9401-9403 IN denotes as
T4433 9391-9400 VBN denotes presented
T4432 9386-9390 VBD denotes were
T4431 9381-9385 NNS denotes data
T4430 9377-9380 NNP denotes All
T4429 9368-9376 NNP denotes Analysis
T4428 9356-9367 NNP denotes Statistical
T4427 9354-9355 . denotes .
T4426 9351-9354 CD denotes 2.7
T4344 9348-9349 . denotes .
T4343 9339-9348 VBN denotes described
T4342 9328-9338 RB denotes previously
T4341 9325-9327 IN denotes as
T4340 9313-9324 NN denotes specificity
T4339 9305-9312 JJ denotes binding
T4338 9300-9304 NNP denotes NFκB
T4337 9292-9299 VB denotes confirm
T4336 9289-9291 TO denotes to
T4335 9279-9288 VBN denotes performed
T4334 9275-9278 VBD denotes was
T4333 9271-9274 NNP denotes P50
T4332 9267-9270 CC denotes and
T4331 9263-9266 NNP denotes P65
T4330 9260-9262 TO denotes to
T4329 9249-9259 NNS denotes antibodies
T4328 9243-9248 VBG denotes using
T4327 9237-9242 NN denotes assay
T4326 9231-9236 NN denotes shift
T4325 9225-9230 JJ denotes super
T4324 9223-9224 DT denotes A
T4323 9221-9222 . denotes .
T4322 9206-9221 NN denotes oligonucleotide
T4321 9196-9205 NN denotes consensus
T4320 9191-9195 NNP denotes NFκB
T4319 9175-9190 JJ denotes double-stranded
T4318 9167-9174 VBD denotes labeled
T4317 9165-9166 NNP denotes ]
T4316 9160-9165 NNP denotes γ-32P
T4315 9159-9160 NNP denotes [
T4314 9154-9158 NN denotes fmol
T4313 9151-9153 CD denotes 35
T4312 9147-9150 CC denotes and
T4311 9138-9146 NNS denotes proteins
T4310 9130-9137 JJ denotes nuclear
T4309 9127-9129 IN denotes of
T4308 9124-9126 NN denotes μg
T4307 9121-9123 CD denotes 15
T4306 9110-9120 VBG denotes containing
T4305 9102-9109 NN denotes mixture
T4304 9093-9101 NN denotes reaction
T4303 9085-9092 JJ denotes binding
T4302 9082-9084 NN denotes μL
T4301 9079-9081 CD denotes 15
T4300 9077-9078 DT denotes a
T4299 9074-9076 IN denotes in
T4298 9065-9073 VBN denotes examined
T4297 9061-9064 VBD denotes was
T4296 9052-9060 NN denotes activity
T4295 9044-9051 JJ denotes binding
T4294 9039-9043 NNP denotes NFκB
T4293 9037-9038 . denotes .
T4292 9036-9037 NN denotes ]
T4291 9035-9036 CD denotes 8
T4290 9034-9035 JJ denotes [
T4289 9023-9033 RB denotes previously
T4288 9013-9022 VBN denotes described
T4287 9010-9012 IN denotes as
T4286 9000-9009 VBN denotes performed
T4285 8996-8999 VBD denotes was
T4284 8991-8995 NNP denotes EMSA
T4283 8989-8990 . denotes .
T4282 8986-8989 NN denotes use
T4281 8980-8985 IN denotes until
T4280 8978-8979 NNP denotes C
T4279 8977-8978 CD denotes °
T4278 8975-8977 CD denotes 80
T4277 8974-8975 CD denotes −
T4276 8971-8973 IN denotes at
T4275 8964-8970 VBD denotes stored
T4274 8960-8963 CC denotes and
T4273 8955-8959 NN denotes tube
T4272 8944-8954 JJ denotes prechilled
T4271 8938-8943 JJ denotes clean
T4270 8936-8937 DT denotes a
T4269 8933-8935 TO denotes to
T4268 8921-8932 VBN denotes transferred
T4267 8916-8920 VBD denotes were
T4266 8914-8915 -RRB- denotes )
T4265 8907-8914 VB denotes extract
T4264 8899-8906 JJ denotes nuclear
T4263 8898-8899 -LRB- denotes (
T4262 8885-8897 NNS denotes supernatants
T4261 8881-8884 DT denotes The
T4260 8879-8880 . denotes .
T4259 8872-8879 NNS denotes minutes
T4258 8869-8871 CD denotes 10
T4257 8865-8868 IN denotes for
T4256 8854-8864 NN denotes centrifuge
T4255 8848-8853 NN denotes micro
T4254 8846-8847 DT denotes a
T4253 8843-8845 IN denotes in
T4252 8841-8842 -RRB- denotes )
T4251 8840-8841 NN denotes g
T4250 8838-8839 CD denotes ×
T4249 8831-8837 CD denotes 16,000
T4248 8830-8831 FW denotes ~
T4247 8829-8830 -LRB- denotes (
T4246 8823-8828 NN denotes speed
T4245 8815-8822 JJ denotes maximum
T4244 8812-8814 IN denotes at
T4243 8800-8811 VBN denotes centrifuged
T4242 8795-8799 VBD denotes were
T4241 8789-8794 NNS denotes tubes
T4240 8785-8788 DT denotes The
T4713 9908-9921 RB denotes significantly
T4712 9904-9907 NNP denotes ICH
T4711 9898-9903 IN denotes after
T4710 9893-9897 NNP denotes mRNA
T4709 9888-9892 NNP denotes TLR4
T4708 9884-9887 DT denotes the
T4707 9882-9883 , denotes ,
T4706 9875-9882 RB denotes However
T4705 9873-9874 . denotes .
T4704 9868-9873 NN denotes group
T4703 9861-9867 JJ denotes normal
T4702 9856-9860 IN denotes from
T4701 9846-9855 JJ denotes different
T4700 9832-9845 RB denotes significantly
T4699 9828-9831 RB denotes not
T4698 9824-9827 VBD denotes was
T4697 9820-9823 CC denotes but
T4696 9818-9819 , denotes ,
T4695 9809-9818 VBD denotes increased
T4694 9800-9808 RB denotes slightly
T4693 9795-9799 NNP denotes mRNA
T4692 9790-9794 CD denotes TLR4
T4691 9786-9789 DT denotes the
T4690 9784-9785 , denotes ,
T4689 9779-9784 NN denotes group
T4688 9771-9778 NN denotes control
T4687 9764-9770 NN denotes saline
T4686 9760-9763 DT denotes the
T4685 9757-9759 IN denotes In
T4684 9755-9756 . denotes .
T4683 9749-9755 NN denotes tissue
T4682 9743-9748 NN denotes brain
T4681 9739-9742 NN denotes rat
T4680 9732-9738 JJ denotes normal
T4679 9729-9731 IN denotes in
T4678 9720-9728 VBN denotes observed
T4677 9716-9719 VBD denotes was
T4676 9711-9715 NNP denotes mRNA
T4675 9706-9710 CD denotes TLR4
T4674 9703-9705 IN denotes of
T4673 9697-9702 NN denotes level
T4672 9693-9696 JJ denotes low
T4671 9689-9692 DT denotes The
T4670 9687-9688 . denotes .
T4669 9681-9687 NNP denotes Rt-PCR
T4668 9678-9680 IN denotes by
T4667 9669-9677 VBN denotes detected
T4666 9664-9668 VBD denotes were
T4665 9657-9663 NNS denotes levels
T4664 9652-9656 NNP denotes mRNA
T4663 9647-9651 CD denotes TLR4
T4662 9643-9646 NNP denotes ICH
T4661 9637-9642 IN denotes after
T4660 9630-9636 NNP denotes Tissue
T4659 9624-9629 NNP denotes Brain
T4658 9621-9623 IN denotes in
T4657 9611-9620 VBN denotes Increased
T4656 9606-9610 NNP denotes mRNA
T4655 9601-9605 CD denotes TLR4
T4654 9599-9600 . denotes .
T4653 9596-9599 CD denotes 3.1
T4218 8677-8680 DT denotes The
T4217 8675-8676 . denotes .
T4216 8668-8675 NN denotes reagent
T4215 8657-8667 NN denotes extraction
T4214 8649-8656 JJ denotes nuclear
T4213 8646-8648 IN denotes in
T4212 8634-8645 VBN denotes resuspended
T4211 8629-8633 VBD denotes were
T4210 8621-8628 NNS denotes pellets
T4209 8617-8620 DT denotes the
T4208 8615-8616 , denotes ,
T4207 8614-8615 -RRB- denotes )
T4206 8607-8614 VB denotes extract
T4205 8595-8606 JJ denotes cytoplasmic
T4204 8594-8595 -LRB- denotes (
T4203 8582-8593 JJ denotes supernatant
T4202 8579-8581 IN denotes of
T4201 8571-8578 NN denotes removal
T4200 8565-8570 IN denotes after
T4199 8563-8564 , denotes ,
T4198 8556-8563 RB denotes Briefly
T4197 8554-8555 . denotes .
T4196 8548-8554 NN denotes tissue
T4195 8542-8547 NN denotes brain
T4194 8537-8541 IN denotes from
T4193 8528-8536 VBN denotes isolated
T4192 8523-8527 VBD denotes were
T4191 8514-8522 NNS denotes proteins
T4190 8506-8513 NNP denotes Nuclear
T4189 8504-8505 -RRB- denotes )
T4188 8500-8504 NNP denotes EMSA
T4187 8499-8500 -LRB- denotes (
T4186 8493-8498 NNP denotes Assay
T4185 8487-8492 NNP denotes Shift
T4184 8478-8486 NNP denotes Mobility
T3957 8454-8455 . denotes .
T3956 8446-8454 NN denotes analysis
T3955 8440-8445 NN denotes image
T3954 8422-8439 JJ denotes computer-assisted
T3953 8418-8421 CC denotes and
T3952 8405-8417 NN denotes densitometry
T3951 8396-8404 VBG denotes scanning
T3950 8393-8395 IN denotes by
T3949 8382-8392 VBN denotes quantified
T3948 8377-8381 VBD denotes were
T3947 8369-8376 NNS denotes signals
T3946 8365-8368 DT denotes The
T3945 8363-8364 . denotes .
T3944 8357-8363 NN denotes buffer
T3943 8347-8356 VBG denotes stripping
T3942 8342-8346 IN denotes with
T3941 8335-8341 VBN denotes washed
T3940 8329-8334 VBG denotes being
T3939 8323-8328 IN denotes after
T3938 8321-8322 -RRB- denotes )
T3937 8316-8321 NNP denotes Maine
T3936 8314-8315 , denotes ,
T3935 8310-8314 NNP denotes Saco
T3934 8308-8309 , denotes ,
T3933 8299-8308 NNP denotes Biodesign
T3932 8297-8298 , denotes ,
T3931 8284-8297 NN denotes dehydrogenase
T3930 8257-8283 JJ denotes glyceraldehyde-3-phosphate
T3929 8256-8257 -LRB- denotes (
T3928 8245-8255 JJ denotes anti-GAPDH
T3927 8240-8244 IN denotes with
T3926 8233-8239 VBN denotes probed
T3925 8228-8232 VBD denotes were
T3924 8218-8227 NNS denotes membranes
T3923 8213-8217 JJ denotes same
T3922 8209-8212 DT denotes The
T3921 8207-8208 . denotes .
T3920 8206-8207 -RRB- denotes )
T3919 8197-8206 NNP denotes Pharmacia
T3918 8188-8196 NNP denotes Amersham
T3917 8187-8188 -LRB- denotes (
T3916 8180-8186 NN denotes system
T3915 8176-8179 NNP denotes ECL
T3914 8172-8175 DT denotes the
T3913 8167-8171 IN denotes with
T3912 8158-8166 VBN denotes detected
T3911 8153-8157 VBD denotes were
T3910 8145-8152 NNS denotes signals
T3909 8141-8144 DT denotes The
T3908 8139-8140 . denotes .
T3907 8138-8139 -RRB- denotes )
T3906 8131-8138 NNP denotes PV-6001
T3905 8129-8130 , denotes ,
T3904 8123-8129 NNP denotes Bridge
T3903 8116-8122 NNP denotes Golden
T3902 8115-8116 -LRB- denotes (
T3901 8104-8114 NNS denotes antibodies
T3900 8094-8103 JJ denotes secondary
T3899 8072-8093 JJ denotes peroxidase-conjugated
T3898 8067-8071 IN denotes with
T3897 8056-8066 NN denotes incubation
T3896 8053-8055 IN denotes by
T3895 8044-8052 VBN denotes followed
T3894 8042-8043 -RRB- denotes )
T3893 8036-8042 NNP denotes BA1717
T3892 8034-8035 , denotes ,
T3891 8029-8034 JJ denotes WuHan
T3890 8028-8029 -LRB- denotes (
T3889 8019-8027 NN denotes antibody
T3888 8011-8018 JJ denotes primary
T3887 7999-8010 JJ denotes appropriate
T3886 7995-7998 DT denotes the
T3885 7990-7994 IN denotes with
T3884 7980-7989 VBN denotes incubated
T3883 7975-7979 VBD denotes were
T3882 7965-7974 NNS denotes membranes
T3881 7961-7964 NNP denotes ECL
T3880 7957-7960 DT denotes The
T3879 7955-7956 . denotes .
T3878 7954-7955 -RRB- denotes )
T3877 7952-7954 NNP denotes NJ
T3876 7950-7951 , denotes ,
T3875 7940-7950 NNP denotes Piscataway
T3874 7938-7939 , denotes ,
T3873 7929-7938 NNP denotes Pharmacia
T3872 7920-7928 NNP denotes Amersham
T3871 7919-7920 -LRB- denotes (
T3870 7909-7918 NNS denotes membranes
T3869 7905-7908 NNP denotes ECL
T3868 7898-7904 NNP denotes Hybond
T3867 7893-7897 IN denotes onto
T3866 7881-7892 VBN denotes transferred
T3865 7877-7880 CC denotes and
T3864 7873-7876 NN denotes gel
T3863 7854-7872 JJ denotes SDS-polyacrylamide
T3862 7849-7853 IN denotes with
T3861 7833-7848 VBN denotes electrophoresed
T3860 7831-7832 , denotes ,
T3859 7820-7831 NNS denotes hemispheres
T3858 7811-7819 JJ denotes cerebral
T3857 7807-7810 NNP denotes ICH
T3856 7802-7806 IN denotes from
T3855 7793-7801 VBN denotes prepared
T3854 7788-7792 VBD denotes were
T3853 7779-7787 NNS denotes proteins
T3852 7770-7778 NNP denotes Cellular
T3851 7764-7769 NNP denotes Blots
T3850 7756-7763 JJ denotes Western
T3849 7754-7755 . denotes .
T3848 7751-7754 CD denotes 2.5
T3662 7670-7671 , denotes ,
T3661 7666-7670 NNP denotes Cruz
T3660 7660-7665 NNP denotes Santa
T3659 7659-7660 -LRB- denotes (
T3658 7654-7658 NNP denotes Inc.
T3657 7640-7653 NNP denotes Biotechnology
T3656 7635-7639 NNP denotes Cruz
T3655 7629-7634 NNP denotes Santa
T3654 7624-7628 IN denotes from
T3653 7615-7623 VBN denotes obtained
T3652 7610-7614 VBD denotes were
T3651 7608-7609 -RRB- denotes )
T3650 7601-7608 NN denotes SC-2018
T3649 7599-7600 , denotes ,
T3648 7592-7599 NN denotes reagent
T3647 7588-7591 NNP denotes ABC
T3646 7587-7588 -LRB- denotes (
T3645 7577-7586 NNS denotes complexes
T3644 7543-7576 JJ denotes antibody-biotin-avidin-peroxidase
T3643 7539-7542 CC denotes and
T3642 7530-7538 NN denotes antibody
T3641 7520-7529 JJ denotes secondary
T3640 7507-7519 JJ denotes biotinylated
T3639 7503-7506 DT denotes The
T3638 7501-7502 . denotes .
T3637 7500-7501 -RRB- denotes )
T3636 7494-7500 NNP denotes BA1717
T3635 7492-7493 , denotes ,
T3634 7487-7492 JJ denotes WuHan
T3633 7486-7487 -LRB- denotes (
T3632 7476-7485 NN denotes anti-TLR4
T3631 7469-7475 NN denotes rabbit
T3630 7465-7468 VBD denotes was
T3629 7456-7464 VBN denotes employed
T3628 7447-7455 NN denotes antibody
T3627 7439-7446 JJ denotes primary
T4183 8462-8477 NNP denotes Electrophoretic
T4182 8460-8461 . denotes .
T4181 8457-8460 CD denotes 2.6
T3626 7435-7438 DT denotes The
T3625 7433-7434 . denotes .
T3624 7432-7433 NN denotes ]
T3623 7431-7432 CD denotes 8
T3622 7430-7431 JJ denotes [
T3621 7419-7429 RB denotes previously
T3620 7409-7418 VBN denotes described
T3619 7406-7408 IN denotes as
T3618 7396-7405 VBN denotes performed
T3617 7392-7395 VBD denotes was
T3616 7387-7391 CD denotes TLR4
T3615 7383-7386 IN denotes for
T3614 7374-7382 VBG denotes staining
T3613 7370-7373 NNP denotes IHC
T3612 7366-7369 DT denotes The
T3611 7364-7365 -RRB- denotes )
T3610 7361-7364 NNP denotes IHC
T3609 7360-7361 -LRB- denotes (
T3608 7339-7359 NNP denotes Immunohistochemistry
T3607 7337-7338 . denotes .
T3606 7334-7337 CD denotes 2.4
T3373 7331-7332 . denotes .
T3372 7327-7331 NNP denotes mRNA
T3371 7319-7326 VB denotes β-actin
T3370 7316-7318 TO denotes to
T3369 7311-7315 NNP denotes mRNA
T3368 7306-7310 CD denotes TLR4
T3367 7303-7305 IN denotes of
T3366 7297-7302 NN denotes ratio
T3365 7293-7296 DT denotes the
T3364 7290-7292 IN denotes as
T3363 7280-7289 VBN denotes expressed
T3362 7276-7279 VBD denotes was
T3361 7271-7275 NNP denotes mRNA
T3360 7266-7270 CD denotes TLR4
T3359 7263-7265 IN denotes of
T3358 7253-7262 NN denotes abundance
T3357 7249-7252 DT denotes The
T3356 7247-7248 . denotes .
T3355 7238-7247 NNS denotes densities
T3354 7233-7237 NN denotes band
T3353 7223-7232 VB denotes determine
T3352 7220-7222 TO denotes to
T3351 7215-7219 VBN denotes used
T3350 7210-7214 VBD denotes were
T3349 7201-7209 NN denotes software
T3348 7192-7200 NNP denotes Analysis
T3347 7188-7191 CC denotes and
T3346 7176-7187 NNP denotes Acquisition
T3345 7170-7175 NN denotes Image
T3344 7168-7169 . denotes .
T3343 7165-7168 NN denotes gel
T3342 7157-7164 JJ denotes agarose
T3341 7149-7156 IN denotes through
T3340 7133-7148 VBN denotes electrophoresed
T3339 7128-7132 VBD denotes were
T3338 7119-7127 NNS denotes products
T3337 7115-7118 NNP denotes PCR
T3336 7113-7114 . denotes .
T3335 7107-7113 NNS denotes cycles
T3334 7104-7106 CD denotes 31
T3333 7098-7103 RB denotes after
T3332 7090-7097 VBN denotes stopped
T3331 7086-7089 VBD denotes was
T3330 7077-7085 NN denotes reaction
T3329 7073-7076 DT denotes The
T3328 7071-7072 . denotes .
T3327 7070-7071 PRP denotes s
T3326 7067-7069 CD denotes 60
T3325 7065-7066 NNP denotes C
T3324 7064-7065 NN denotes °
T3323 7062-7064 CD denotes 72
T3322 7058-7061 CC denotes and
T3321 7056-7057 , denotes ,
T3320 7055-7056 PRP denotes s
T3319 7052-7054 CD denotes 40
T3318 7050-7051 NNP denotes C
T3317 7049-7050 NN denotes °
T3316 7047-7049 CD denotes 55
T3315 7045-7046 , denotes ,
T3314 7044-7045 PRP denotes s
T3313 7041-7043 CD denotes 40
T3312 7039-7040 NNP denotes C
T3311 7038-7039 NN denotes °
T3310 7036-7038 CD denotes 94
T3309 7034-7035 , denotes ,
T3308 7031-7034 NN denotes min
T3307 7029-7030 CD denotes 2
T3306 7027-7028 NNP denotes C
T3305 7026-7027 NN denotes °
T3304 7024-7026 CD denotes 94
T3303 7022-7023 : denotes :
T3302 7013-7022 NN denotes condition
T3301 7003-7012 JJ denotes following
T3300 6999-7002 DT denotes the
T3299 6996-6998 IN denotes at
T3298 6986-6995 VBN denotes performed
T3297 6981-6985 VBD denotes were
T3296 6974-6980 NNS denotes cycles
T3295 6965-6973 NN denotes Reaction
T3294 6963-6964 . denotes .
T3293 6962-6963 NN denotes ′
T3292 6941-6962 NN denotes CCAGGATAGAGCCACCAAT-3
T3291 6940-6941 : denotes -
T3290 6939-6940 SYM denotes ′
T3289 6938-6939 CD denotes 5
T3288 6936-6937 : denotes :
T3287 6929-6936 NN denotes reverse
T3286 6927-6928 : denotes ;
T3285 6926-6927 NN denotes ′
T3284 6905-6926 NN denotes GCCAACCGTGAAAAAGATG-3
T3283 6904-6905 : denotes -
T3282 6903-6904 SYM denotes ′
T3281 6902-6903 CD denotes 5
T3280 6900-6901 : denotes :
T3279 6893-6900 RB denotes forward
T3278 6891-6892 : denotes :
T3277 6890-6891 -RRB- denotes )
T3276 6888-6890 NN denotes bp
T3275 6884-6887 CD denotes 701
T3274 6883-6884 -LRB- denotes (
T3273 6875-6882 NN denotes β-actin
T3272 6873-6874 : denotes ;
T3271 6872-6873 NN denotes ′
T3270 6850-6872 NN denotes CAGGATGACACCATTGAAGC-3
T3269 6849-6850 : denotes -
T3268 6848-6849 SYM denotes ′
T3267 6847-6848 CD denotes 5
T3266 6845-6846 : denotes :
T3265 6838-6845 NN denotes reverse
T3264 6836-6837 : denotes ;
T3263 6835-6836 NN denotes ′
T3262 6813-6835 NN denotes AGCTTTGGTCAGTTGGCTCT-3
T3261 6812-6813 : denotes -
T3260 6811-6812 SYM denotes ′
T3259 6810-6811 CD denotes 5
T3258 6808-6809 : denotes :
T3257 6801-6808 RB denotes forward
T3256 6799-6800 : denotes :
T3255 6798-6799 -RRB- denotes )
T3254 6796-6798 NN denotes bp
T3253 6792-6795 CD denotes 145
T3252 6791-6792 -LRB- denotes (
T3251 6786-6790 CD denotes TLR4
T3250 6784-6785 . denotes .
T3249 6777-6784 NNP denotes GenBank
T3248 6774-6776 IN denotes in
T3247 6765-6773 VBD denotes reported
T3246 6755-6764 NNS denotes sequences
T3245 6750-6754 NN denotes gene
T3244 6742-6749 JJ denotes β-actin
T3243 6738-6741 CC denotes and
T3242 6733-6737 CD denotes TLR4
T3241 6729-6732 DT denotes the
T3240 6726-6728 TO denotes to
T3239 6716-6725 VBG denotes according
T3238 6707-6715 VBN denotes designed
T3237 6702-6706 VBD denotes were
T3236 6692-6701 NNS denotes sequences
T3235 6685-6691 NN denotes primer
T3234 6681-6684 NNP denotes PCR
T3233 6677-6680 DT denotes The
T3232 6675-6676 . denotes .
T3231 6668-6675 NN denotes control
T3230 6659-6667 JJ denotes internal
T3229 6656-6658 DT denotes an
T3228 6653-6655 IN denotes as
T3227 6648-6652 VBN denotes used
T3226 6644-6647 VBD denotes was
T3225 6642-6643 -RRB- denotes )
T3224 6635-6642 NN denotes β-actin
T3223 6634-6635 -LRB- denotes (
T3222 6629-6633 NN denotes gene
T3221 6624-6628 VB denotes keep
T3220 6618-6623 NN denotes house
T3219 6614-6617 DT denotes The
T3218 6612-6613 . denotes .
T3217 6602-6612 NN denotes polymerase
T3216 6598-6601 NNP denotes DNA
T3215 6594-6597 NNP denotes Taq
T3214 6591-6593 CD denotes 2u
T3213 6587-6590 CC denotes and
T3212 6585-6586 , denotes ,
T3211 6578-6585 NNS denotes primers
T3210 6575-6577 IN denotes of
T3209 6572-6574 NN denotes μM
T3208 6568-6571 CD denotes 200
T3207 6566-6567 , denotes ,
T3206 6562-6566 NNP denotes dNTP
T3205 6557-6561 DT denotes each
T3204 6554-6556 IN denotes of
T3203 6551-6553 NN denotes μM
T3202 6547-6550 CD denotes 200
T3201 6545-6546 , denotes ,
T3200 6540-6545 NNP denotes MgCl2
T3199 6537-6539 NNP denotes mM
T3198 6533-6536 CD denotes 1.5
T3087 5909-5913 IN denotes from
T3086 5900-5908 VBN denotes isolated
T3085 5895-5899 VBD denotes were
T3084 5887-5894 NNS denotes samples
T3083 5883-5886 NNP denotes RNA
T3082 5877-5882 JJ denotes total
T3081 5875-5876 , denotes ,
T3080 5868-5875 NNP denotes Briefly
T3079 5861-5867 NNP denotes RT-PCR
T3078 5858-5860 IN denotes of
T3077 5851-5857 NNP denotes Method
T3076 5847-5850 DT denotes the
T3075 5844-5846 IN denotes by
T3074 5839-5843 NNP denotes mRNA
T3073 5834-5838 NNP denotes TLR4
T3072 5831-5833 IN denotes of
T3071 5821-5830 NNP denotes Detection
T3070 5819-5820 . denotes .
T3069 5816-5819 CD denotes 2.3
T2535 5164-5171 JJ denotes sterile
T2534 5162-5163 DT denotes a
T2533 5156-5161 VBG denotes Using
T2532 5154-5155 . denotes .
T2531 5147-5154 NN denotes midline
T2530 5143-5146 DT denotes the
T2529 5137-5142 IN denotes along
T2528 5129-5136 VBN denotes incised
T2527 5125-5128 VBD denotes was
T2526 5119-5124 NN denotes scalp
T2525 5115-5118 DT denotes the
T2524 5111-5114 CC denotes and
T2523 5109-5110 , denotes ,
T2522 5104-5109 NN denotes frame
T2521 5091-5103 JJ denotes stereotactic
T2520 5089-5090 DT denotes a
T2519 5086-5088 IN denotes in
T2518 5075-5085 VBN denotes positioned
T2517 5070-5074 VBD denotes were
T2516 5065-5069 NNS denotes rats
T2515 5061-5064 DT denotes The
T2514 5059-5060 . denotes .
T2513 5053-5059 NN denotes system
T2512 5045-5052 NN denotes heating
T2511 5025-5044 JJ denotes feedback-controlled
T2510 5023-5024 DT denotes a
T2509 5017-5022 VBG denotes using
T2508 5009-5016 NN denotes surgery
T2507 5005-5008 DT denotes the
T2506 4998-5004 IN denotes during
T2505 4996-4997 NNP denotes C
T2504 4995-4996 CD denotes °
T2503 4993-4995 CD denotes 37
T2502 4990-4992 IN denotes at
T2501 4979-4989 VBN denotes maintained
T2500 4975-4978 VBD denotes was
T2499 4963-4974 NN denotes temperature
T2498 4961-4962 -RRB- denotes )
T2497 4955-4961 JJ denotes rectal
T2496 4954-4955 -LRB- denotes (
T2495 4949-4953 NN denotes body
T2494 4945-4948 DT denotes The
T2493 4943-4944 . denotes .
T2492 4942-4943 -RRB- denotes )
T2491 4937-4942 NN denotes mg/kg
T2490 4934-4936 CD denotes 60
T2489 4933-4934 -LRB- denotes (
T2488 4919-4932 JJ denotes pentobarbital
T2487 4912-4918 NN denotes sodium
T2486 4895-4911 JJ denotes intra-peritoneal
T2485 4890-4894 IN denotes with
T2484 4877-4889 JJ denotes anesthetized
T2483 4872-4876 VBD denotes were
T2482 4867-4871 NNS denotes Rats
T2481 4865-4866 . denotes .
T2480 4858-4865 NNS denotes ganglia
T2479 4852-4857 JJ denotes basal
T2478 4847-4851 JJ denotes left
T2477 4844-4846 IN denotes in
T2476 4836-4843 VBN denotes induced
T2475 4832-4835 VBD denotes was
T2474 4828-4831 NNP denotes ICH
T2473 4825-4827 IN denotes of
T2472 4819-4824 NN denotes model
T2471 4815-4818 NN denotes rat
T2470 4813-4814 , denotes ,
T2469 4808-4813 NN denotes study
T2468 4800-4807 JJ denotes present
T2467 4796-4799 DT denotes the
T2466 4793-4795 IN denotes in
T2465 4791-4792 , denotes ,
T2464 4781-4791 RB denotes clinically
T2463 4773-4780 NN denotes ganglia
T2462 4767-4772 JJ denotes basal
T2461 4763-4766 DT denotes the
T2460 4760-4762 IN denotes in
T2459 4754-4759 VBP denotes occur
T2458 4742-4753 NNS denotes hemorrhages
T2457 4728-4741 JJ denotes intracerebral
T2456 4723-4727 JJS denotes most
T2455 4717-4722 IN denotes Since
T2454 4706-4716 NNP denotes Hemorrhage
T2453 4692-4705 NNP denotes Intracerebral
T2452 4689-4691 IN denotes of
T2451 4679-4688 NNP denotes Induction
T2450 4677-4678 . denotes .
T2449 4674-4677 CD denotes 2.2
T3197 6531-6532 , denotes ,
T3196 6525-6531 NN denotes buffer
T3195 6521-6524 NNP denotes PCR
T3194 6519-6520 CD denotes ×
T3193 6518-6519 CD denotes 1
T3192 6513-6517 IN denotes with
T3191 6504-6512 NN denotes fragment
T3190 6499-6503 NN denotes gene
T3189 6494-6498 CD denotes TLR4
T3188 6490-6493 DT denotes the
T3187 6482-6489 VB denotes amplify
T3186 6479-6481 TO denotes to
T3185 6474-6478 VBN denotes used
T3184 6470-6473 VBD denotes was
T3183 6465-6469 NNP denotes cDNA
T3182 6462-6464 IN denotes of
T3181 6451-6461 NN denotes microliter
T3180 6447-6450 CD denotes One
T3179 6445-6446 . denotes .
T3178 6437-6445 NN denotes supplier
T3177 6433-6436 DT denotes the
T3176 6430-6432 IN denotes by
T3175 6420-6429 VBN denotes described
T3174 6409-6419 NNS denotes conditions
T3173 6403-6408 IN denotes under
T3172 6401-6402 -RRB- denotes )
T3171 6398-6401 NNP denotes Inc
T3170 6390-6397 JJ denotes promega
T3169 6389-6390 -LRB- denotes (
T3168 6382-6388 NNP denotes RT-PCR
T3167 6378-6381 IN denotes for
T3166 6374-6377 NNP denotes Kit
T3165 6364-6373 NNP denotes Synthesis
T3164 6351-6363 NNP denotes First-Strand
T3163 6339-6350 NNP denotes Superscript
T3162 6333-6338 VBG denotes using
T3161 6326-6332 NN denotes system
T3160 6317-6325 NN denotes reaction
T3159 6314-6316 NN denotes μL
T3158 6311-6313 CD denotes 20
T3157 6308-6310 IN denotes in
T3156 6303-6307 NNP denotes cDNA
T3155 6298-6302 IN denotes into
T3154 6278-6297 VBN denotes reverse-transcribed
T3153 6274-6277 VBD denotes was
T3152 6270-6273 NNP denotes RNA
T3151 6268-6269 . denotes .
T3150 6264-6268 NNP denotes g/mL
T3149 6260-6263 CD denotes 1.0
T3148 6257-6259 TO denotes to
T3147 6248-6256 VBN denotes adjusted
T3146 6243-6247 VBD denotes were
T3145 6238-6242 NNP denotes mRNA
T3144 6235-6237 IN denotes of
T3143 6220-6234 NNS denotes concentrations
T3142 6216-6219 DT denotes the
T3141 6214-6215 , denotes ,
T3140 6210-6214 RB denotes Then
T3139 6208-6209 . denotes .
T3138 6198-6208 NN denotes wavelength
T3137 6195-6197 NN denotes nm
T3136 6190-6194 CD denotes A280
T3135 6186-6189 CC denotes and
T3134 6181-6185 CD denotes A260
T3133 6178-6180 IN denotes at
T3132 6170-6177 NN denotes density
T3131 6162-6169 JJ denotes optical
T3130 6152-6161 VBG denotes measuring
T3129 6149-6151 IN denotes by
T3128 6147-6148 -RRB- denotes )
T3127 6130-6147 NNP denotes Spectrophotometer
T3126 6122-6129 NNP denotes ND-1000
T3125 6121-6122 -LRB- denotes (
T3124 6112-6120 NNP denotes Nanodrop
T3123 6110-6111 DT denotes a
T3122 6107-6109 IN denotes on
T3121 6096-6106 VBN denotes determined
T3120 6092-6095 VBD denotes was
T3119 6088-6091 NNP denotes RNA
T3118 6082-6087 JJ denotes total
T3117 6079-6081 IN denotes of
T3116 6070-6078 NN denotes quantity
T3115 6066-6069 DT denotes The
T3114 6064-6065 . denotes .
T3113 6052-6064 NNS denotes instructions
T3112 6049-6051 POS denotes 's
T3111 6037-6049 NN denotes manufacturer
T3110 6033-6036 DT denotes the
T3109 6030-6032 TO denotes to
T3108 6020-6029 VBG denotes according
T3107 6018-6019 -RRB- denotes )
T3106 6013-6018 NNP denotes China
T3105 6011-6012 , denotes ,
T3104 6009-6011 NNP denotes HZ
T3103 6007-6008 , denotes ,
T3102 6000-6007 NNP denotes BioFlux
T3101 5999-6000 -LRB- denotes (
T3100 5995-5998 NN denotes Kit
T3099 5985-5994 NN denotes isolation
T3098 5981-5984 NNP denotes RNA
T3097 5975-5980 NNP denotes Total
T3096 5973-5974 NNP denotes P
T3095 5966-5972 RB denotes Simply
T3094 5960-5965 VBG denotes using
T3093 5952-5959 NN denotes ganglia
T3092 5946-5951 JJ denotes basal
T3091 5941-5945 JJ denotes left
T3090 5938-5940 IN denotes in
T3089 5930-5937 NNS denotes regions
T2216 4671-4672 . denotes .
T2215 4666-4671 NNP denotes Blots
T2214 4658-4665 NNP denotes Western
T2213 4654-4657 CC denotes and
T2212 4647-4653 NNP denotes RT-PCR
T2211 4643-4646 IN denotes for
T2210 4641-4642 NNP denotes C
T2209 4640-4641 CD denotes °
T2208 4638-4640 CD denotes 80
T2207 4632-4637 CC denotes minus
T2206 4629-4631 IN denotes at
T2205 4622-4628 VBN denotes stored
T2204 4618-4621 CC denotes and
T2203 4610-4617 VBN denotes removed
T2202 4605-4609 VBD denotes were
T2201 4598-4604 NNS denotes brains
T2200 4594-4597 DT denotes The
T2199 4592-4593 . denotes .
T2198 4584-4592 NNP denotes Ketamine
T2197 4581-4583 IN denotes of
T2196 4571-4580 NN denotes injection
T2195 4566-4570 NN denotes dose
T2194 4561-4565 IN denotes over
T2193 4558-4560 IN denotes by
T2192 4547-4557 VBN denotes sacrificed
T2191 4542-4546 VBD denotes were
T2190 4536-4541 NN denotes point
T2189 4531-4535 NN denotes time
T2188 4526-4530 DT denotes each
T2187 4523-4525 IN denotes at
T2186 4517-4522 NN denotes group
T2185 4512-4516 DT denotes each
T2184 4509-4511 IN denotes in
T2183 4504-4508 NNS denotes rats
T2182 4499-4503 CD denotes Five
T2181 4497-4498 . denotes .
T2180 4496-4497 NN denotes ]
T2179 4495-4496 CD denotes 8
T2178 4494-4495 JJ denotes [
T2177 4483-4493 RB denotes previously
T2176 4473-4482 VBN denotes described
T2175 4470-4472 IN denotes as
T2174 4468-4469 -RRB- denotes )
T2173 4466-4468 NN denotes μm
T2172 4464-4465 CD denotes 7
T2171 4463-4464 -LRB- denotes (
T2170 4454-4462 NNS denotes sections
T2169 4449-4453 IN denotes into
T2168 4445-4448 VBD denotes cut
T2167 4441-4444 CC denotes and
T2166 4439-4440 , denotes ,
T2165 4431-4439 NN denotes paraffin
T2164 4428-4430 IN denotes in
T2163 4419-4427 VBN denotes embedded
T2162 4417-4418 , denotes ,
T2161 4408-4417 VBN denotes postfixed
T2160 4406-4407 , denotes ,
T2159 4399-4406 VBN denotes removed
T2158 4394-4398 VBD denotes were
T2157 4387-4393 NNS denotes brains
T2156 4383-4386 DT denotes The
T2155 4381-4382 . denotes .
T2154 4380-4381 -RRB- denotes )
T2153 4377-4380 CD denotes 7.4
T2152 4375-4376 SYM denotes =
T2151 4372-4374 NNP denotes pH
T2150 4371-4372 -LRB- denotes (
T2149 4358-4370 NN denotes formaldehyde
T2148 4353-4357 NNP denotes Para
T2147 4344-4352 VBD denotes buffered
T2146 4342-4343 NN denotes %
T2145 4341-4342 CD denotes 4
T2144 4338-4340 IN denotes by
T2143 4329-4337 VBN denotes followed
T2142 4322-4328 NN denotes saline
T2141 4315-4321 JJ denotes normal
T2140 4312-4314 IN denotes of
T2139 4302-4311 NN denotes perfusion
T2138 4287-4301 RB denotes transcardially
T2137 4284-4286 IN denotes by
T2136 4273-4283 VBN denotes sacrificed
T2135 4268-4272 VBD denotes were
T2134 4262-4267 NN denotes point
T2665 5805-5813 VBN denotes injected
T2664 5801-5804 VBD denotes was
T2663 5794-5800 NN denotes saline
T2662 5787-5793 JJ denotes normal
T2661 5784-5786 NN denotes μL
T2660 5781-5783 CD denotes 75
T2659 5776-5780 RB denotes only
T2658 5774-5775 , denotes ,
T2657 5770-5774 NNS denotes rats
T2656 5762-5769 NN denotes control
T2655 5755-5761 NN denotes saline
T2654 5748-5754 JJ denotes normal
T2653 5744-5747 DT denotes the
T2652 5740-5743 IN denotes For
T2651 5738-5739 . denotes .
T2650 5731-5738 NNS denotes sutures
T2649 5726-5730 IN denotes with
T2648 5719-5725 VBN denotes closed
T2647 5715-5718 VBD denotes was
T2646 5706-5714 NN denotes incision
T2645 5701-5705 NN denotes skin
T2644 5697-5700 DT denotes the
T2643 5693-5696 CC denotes and
T2642 5691-5692 , denotes ,
T2641 5687-5691 NN denotes hole
T2640 5682-5686 NN denotes burr
T2639 5678-5681 DT denotes the
T2638 5671-5677 IN denotes around
T2637 5664-5670 VBN denotes placed
T2636 5660-5663 VBD denotes was
T2635 5655-5659 NN denotes glue
T2634 5641-5654 VBP denotes cyanoacrylate
T2633 5639-5640 , denotes ,
T2632 5632-5639 RB denotes quickly
T2631 5622-5631 VBN denotes withdrawn
T2630 5618-5621 VBD denotes was
T2629 5611-5617 NN denotes needle
T2628 5607-5610 DT denotes the
T2627 5605-5606 , denotes ,
T2626 5597-5605 NN denotes infusion
T2625 5593-5596 DT denotes the
T2624 5590-5592 IN denotes of
T2623 5579-5589 NN denotes completion
T2622 5575-5578 DT denotes the
T2621 5569-5574 IN denotes After
T2620 5567-5568 . denotes .
T2619 5563-5567 NN denotes pump
T2618 5549-5562 NN denotes microinfusion
T2617 5547-5548 DT denotes a
T2616 5544-5546 IN denotes of
T2615 5540-5543 NN denotes use
T2614 5536-5539 DT denotes the
T2613 5531-5535 IN denotes with
T2612 5527-5530 NN denotes min
T2611 5526-5527 NNP denotes /
T2610 5524-5526 NNP denotes μL
T2609 5521-5523 CD denotes 20
T2608 5518-5520 IN denotes of
T2607 5513-5517 NN denotes rate
T2606 5511-5512 DT denotes a
T2605 5508-5510 IN denotes at
T2604 5500-5507 VBN denotes infused
T2603 5496-5499 VBD denotes was
T2602 5490-5495 NN denotes blood
T2601 5484-5489 JJ denotes whole
T2600 5473-5483 JJ denotes autologous
T2599 5470-5472 IN denotes of
T2598 5467-5469 NN denotes μL
T2597 5464-5466 CD denotes 75
T2596 5462-5463 DT denotes a
T2595 5460-5461 , denotes ,
T2594 5456-5460 RB denotes Then
T2593 5454-5455 . denotes .
T2592 5453-5454 -RRB- denotes )
T2591 5446-5453 NN denotes midline
T2590 5442-5445 DT denotes the
T2589 5439-5441 TO denotes to
T2588 5431-5438 NN denotes lateral
T2587 5428-5430 NN denotes mm
T2586 5424-5427 CD denotes 3.0
T2585 5420-5423 CC denotes and
T2584 5418-5419 , denotes ,
T2583 5411-5418 NN denotes ventral
T2582 5408-5410 NN denotes mm
T2581 5404-5407 CD denotes 6.0
T2580 5402-5403 , denotes ,
T2579 5394-5402 NN denotes anterior
T2578 5391-5393 NN denotes mm
T2577 5387-5390 CD denotes 0.2
T2576 5385-5386 : denotes :
T2575 5374-5385 VBZ denotes coordinates
T2574 5373-5374 -LRB- denotes (
T2573 5364-5372 NN denotes guidance
T2572 5351-5363 JJ denotes stereotactic
T2571 5345-5350 IN denotes under
T2570 5337-5344 NN denotes ganglia
T2569 5331-5336 JJ denotes basal
T2568 5326-5330 JJ denotes left
T2567 5322-5325 DT denotes the
T2566 5317-5321 IN denotes into
T2565 5308-5316 VBN denotes inserted
T2564 5304-5307 VBD denotes was
T2563 5297-5303 NN denotes needle
T2562 5288-5296 JJ denotes 26-gauge
T2561 5282-5287 JJ denotes blunt
T2560 5280-5281 DT denotes A
T2559 5278-5279 . denotes .
T2558 5271-5278 NN denotes midline
T2557 5267-5270 DT denotes the
T2556 5264-5266 TO denotes to
T2555 5256-5263 NN denotes lateral
T2554 5253-5255 NN denotes mm
T2553 5251-5252 CD denotes 3
T2552 5244-5250 NN denotes suture
T2551 5236-5243 JJ denotes coronal
T2550 5231-5235 VBN denotes left
T2549 5227-5230 DT denotes the
T2548 5224-5226 IN denotes on
T2547 5218-5223 NN denotes skull
T2546 5214-5217 DT denotes the
T2545 5211-5213 IN denotes in
T2544 5204-5210 VBN denotes opened
T2543 5200-5203 VBD denotes was
T2542 5195-5199 NN denotes hole
T2541 5190-5194 NN denotes burr
T2540 5187-5189 NN denotes mm
T2539 5185-5186 CD denotes 1
T2538 5183-5184 DT denotes a
T2537 5181-5182 , denotes ,
T2536 5172-5181 NN denotes technique
T2133 4257-4261 NN denotes time
T2132 4252-4256 DT denotes each
T2131 4249-4251 IN denotes at
T2130 4243-4248 NN denotes group
T2129 4238-4242 DT denotes each
T2128 4235-4237 IN denotes in
T2127 4230-4234 NNS denotes rats
T2126 4225-4229 CD denotes Five
T2125 4223-4224 . denotes .
T2124 4211-4223 RB denotes respectively
T2123 4209-4210 , denotes ,
T2122 4200-4209 NN denotes injection
T2121 4196-4199 DT denotes the
T2120 4190-4195 IN denotes after
T2119 4185-4189 NNS denotes days
T2118 4183-4184 CD denotes 7
T2117 4179-4182 CC denotes and
T2116 4174-4178 NNS denotes days
T2115 4172-4173 CD denotes 3
T2114 4170-4171 , denotes ,
T2113 4167-4170 NN denotes day
T2112 4165-4166 CD denotes 1
T2111 4163-4164 , denotes ,
T2110 4158-4163 NNS denotes hours
T2109 4156-4157 CD denotes 6
T2108 4153-4155 IN denotes on
T2107 4142-4152 VBN denotes sacrificed
T2106 4137-4141 VBD denotes were
T2105 4133-4136 CC denotes and
T2104 4127-4132 NN denotes blood
T2103 4121-4126 JJ denotes whole
T2102 4110-4120 JJ denotes autologous
T2101 4107-4109 CC denotes or
T2100 4100-4106 NN denotes saline
T2099 4093-4099 JJ denotes normal
T2098 4090-4092 IN denotes of
T2097 4080-4089 NN denotes injection
T2096 4065-4079 JJ denotes intra-cerebral
T2095 4062-4064 TO denotes to
T2094 4052-4061 VBN denotes subjected
T2093 4047-4051 VBD denotes were
T2092 4042-4046 NNS denotes rats
T2091 4038-4041 DT denotes The
T2090 4036-4037 . denotes .
T2089 4026-4036 NNP denotes University
T2088 4018-4025 NNP denotes Medical
T2087 4012-4017 NNP denotes China
T2086 4010-4011 , denotes ,
T2085 4001-4010 NNP denotes Committee
T2084 3997-4000 NNP denotes Use
T2083 3993-3996 CC denotes and
T2082 3988-3992 NNP denotes Care
T2010 3627-3639 JJ denotes Experimental
T2009 3624-3626 IN denotes by
T2008 3615-3623 VBN denotes provided
T2007 3610-3614 VBD denotes were
T2006 3608-3609 -RRB- denotes )
T2005 3607-3608 NN denotes g
T2004 3603-3606 CD denotes 300
T2003 3600-3602 TO denotes to
T2002 3598-3599 NN denotes g
T2001 3594-3597 CD denotes 250
T2000 3592-3593 : denotes :
T1999 3586-3592 NN denotes weight
T1998 3581-3585 NN denotes body
T1997 3579-3580 , denotes ,
T1996 3575-3579 NN denotes male
T1995 3574-3575 -LRB- denotes (
T1994 3569-3573 NNS denotes rats
T1993 3562-3568 NNP denotes Wister
T1992 3555-3561 CD denotes Ninety
T1991 3547-3554 NNS denotes Animals
T1990 3545-3546 . denotes .
T1989 3542-3545 CD denotes 2.1
T1649 3527-3528 . denotes .
T1648 3524-3527 NNP denotes ICH
T1647 3518-3523 IN denotes after
T1646 3511-3517 NN denotes tissue
T1645 3505-3510 NN denotes brain
T1644 3501-3504 NN denotes rat
T1643 3498-3500 IN denotes in
T1642 3488-3497 VBG denotes signaling
T1641 3474-3487 JJ denotes TLR4-mediated
T1640 3471-3473 IN denotes of
T1639 3460-3470 NN denotes activation
T1638 3456-3459 DT denotes the
T1637 3453-3455 IN denotes of
T1636 3445-3452 NN denotes profile
T1635 3436-3444 JJ denotes temporal
T1611 3284-3297 JJ denotes TLR4-mediated
T1610 3281-3283 IN denotes of
T1609 3270-3280 NN denotes activation
T1608 3266-3269 DT denotes the
T1607 3262-3265 CC denotes and
T1606 3257-3261 NN denotes gene
T1605 3252-3256 CD denotes TLR4
T1604 3249-3251 IN denotes of
T1603 3235-3248 NN denotes transcription
T1602 3231-3234 DT denotes the
T1601 3222-3230 VBD denotes detected
T1600 3219-3221 PRP denotes we
T1599 3217-3218 , denotes ,
T1598 3212-3217 NN denotes study
T1597 3204-3211 JJ denotes present
T1596 3200-3203 DT denotes the
T1595 3197-3199 IN denotes In
T1594 3195-3196 . denotes .
T1593 3192-3195 NNP denotes ICH
T1592 3186-3191 IN denotes after
T1591 3180-3185 NN denotes brain
T1590 3176-3179 DT denotes the
T1589 3173-3175 IN denotes in
T1588 3168-3172 CD denotes TLR4
T1587 3162-3167 IN denotes about
T1586 3156-3161 VBN denotes known
T1585 3153-3155 VBZ denotes is
T1584 3146-3152 JJ denotes little
T1583 3144-3145 , denotes ,
T1582 3137-3144 RB denotes However
T1581 3135-3136 . denotes .
T1580 3134-3135 NN denotes ]
T1579 3133-3134 CD denotes 9
T1578 3131-3132 , denotes ,
T1577 3130-3131 CD denotes 8
T1576 3129-3130 NN denotes [
T1575 3120-3128 NN denotes ischemia
T1574 3117-3119 IN denotes by
T1573 3109-3116 VBN denotes induced
T1572 3102-3108 NN denotes injury
T1571 3096-3101 NN denotes brain
T1570 3092-3095 DT denotes the
T1569 3089-3091 IN denotes in
T1568 3079-3088 NNS denotes responses
T1567 3066-3078 JJ denotes inflammatory
T1566 3062-3065 CC denotes and
T1565 3060-3061 , denotes ,
T2081 3981-3987 NNP denotes Animal
T2080 3977-3980 DT denotes the
T2079 3974-3976 IN denotes by
T2078 3965-3973 VBN denotes approved
T2077 3961-3964 VBD denotes was
T2076 3953-3960 NNS denotes animals
T2075 3949-3952 IN denotes for
T2074 3944-3948 VBN denotes used
T2073 3935-3943 NN denotes protocol
T2072 3922-3934 JJ denotes experimental
T2071 3918-3921 DT denotes The
T2070 3916-3917 . denotes .
T2069 3915-3916 -RRB- denotes )
T2068 3913-3915 CD denotes 40
T2067 3911-3912 SYM denotes =
T2066 3909-3910 JJ denotes n
T2065 3907-3908 , denotes ,
T2064 3904-3907 NNP denotes ICH
T2063 3903-3904 -LRB- denotes (
T2062 3897-3902 NN denotes group
T2061 3886-3896 NN denotes hemorrhage
T2060 3871-3885 JJ denotes intra-cerebral
T2059 3867-3870 CC denotes and
T2058 3865-3866 -RRB- denotes )
T2057 3858-3865 NN denotes control
T2056 3855-3857 IN denotes as
T2055 3848-3854 NN denotes saline
T2054 3841-3847 JJ denotes normal
T2053 3838-3840 IN denotes of
T2052 3828-3837 NN denotes injection
T2051 3813-3827 JJ denotes intra-cerebral
T2050 3811-3812 , denotes ,
T2049 3809-3811 CD denotes 40
T2048 3807-3808 SYM denotes =
T2047 3805-3806 JJ denotes n
T2046 3803-3804 , denotes ,
T2045 3802-3803 NNP denotes S
T2044 3801-3802 -LRB- denotes (
T2043 3793-3800 NN denotes control
T2042 3786-3792 NN denotes saline
T2041 3779-3785 JJ denotes normal
T2040 3777-3778 , denotes ,
T2039 3776-3777 -RRB- denotes )
T2038 3767-3776 NN denotes treatment
T2037 3763-3766 DT denotes any
T2036 3755-3762 IN denotes without
T2035 3753-3754 , denotes ,
T2034 3751-3753 CD denotes 10
T2033 3749-3750 SYM denotes =
T2032 3747-3748 JJ denotes n
T2031 3745-3746 , denotes ,
T2030 3744-3745 NNP denotes N
T2029 3743-3744 -LRB- denotes (
T2028 3737-3742 NN denotes group
T2027 3730-3736 JJ denotes normal
T2026 3728-3729 : denotes :
T2025 3722-3728 NNS denotes groups
T2024 3716-3721 CD denotes three
T2023 3713-3715 TO denotes to
T2022 3704-3712 RB denotes randomly
T2021 3695-3703 VBN denotes assigned
T2020 3690-3694 VBD denotes were
T2019 3685-3689 NNS denotes rats
T2018 3681-3684 DT denotes The
T2017 3679-3680 . denotes .
T2016 3669-3679 NNP denotes University
T2015 3661-3668 NNP denotes Medical
T2014 3655-3660 NNP denotes China
T2013 3653-3654 , denotes ,
T2012 3647-3653 NNP denotes Center
T2011 3640-3646 NNP denotes Animal
T1564 3055-3060 NN denotes edema
T1563 3049-3054 NN denotes brain
T1562 3047-3048 , denotes ,
T1561 3041-3047 NN denotes damage
T1560 3033-3040 NN denotes barrier
T1559 3027-3032 NN denotes brain
T1558 3021-3026 NN denotes blood
T1557 3019-3020 , denotes ,
T1556 3014-3019 NN denotes death
T1555 3005-3013 JJ denotes neuronal
T1554 3001-3004 DT denotes the
T1553 2998-3000 TO denotes to
T1552 2986-2997 VBZ denotes contributes
T1551 2984-2985 , denotes ,
T1550 2974-2984 VBD denotes recognized
T1549 2970-2973 NNP denotes TLR
T1548 2960-2969 JJ denotes mammalian
T1547 2954-2959 JJ denotes first
T1546 2950-2953 DT denotes the
T1545 2948-2949 , denotes ,
T1544 2944-2948 CD denotes TLR4
T1543 2939-2943 IN denotes that
T1542 2927-2938 VBP denotes demonstrate
T1541 2917-2926 NNS denotes evidences
T1540 2904-2916 VBG denotes Accumulating
T1539 2902-2903 . denotes .
T1538 2901-2902 NN denotes ]
T1537 2900-2901 CD denotes 8
T1536 2898-2899 , denotes ,
T1535 2897-2898 CD denotes 7
T1534 2896-2897 NN denotes [
T1533 2889-2895 NN denotes injury
T1532 2883-2888 NN denotes brain
T1531 2874-2882 JJ denotes ischemic
T1530 2870-2873 CC denotes and
T1529 2868-2869 , denotes ,
T1528 2861-2868 NN denotes disease
T1527 2850-2860 JJ denotes autoimmune
T1526 2848-2849 , denotes ,
T1525 2841-2848 NN denotes disease
T1524 2830-2840 JJ denotes infectious
T1523 2827-2829 IN denotes as
T1522 2822-2826 JJ denotes such
T1521 2820-2821 , denotes ,
T1520 2812-2820 NNS denotes diseases
T1519 2808-2811 NNP denotes CNS
T1518 2800-2807 JJ denotes several
T1517 2797-2799 IN denotes in
T1516 2786-2796 VBN denotes implicated
T1515 2782-2785 VBP denotes are
T1514 2778-2781 CC denotes and
T1513 2768-2777 NNS denotes responses
T1365 1867-1868 NNP denotes ]
T1364 1866-1867 CD denotes 3
T1363 1865-1866 NNP denotes [
T1362 1861-1864 NNP denotes ICH
T1361 1851-1860 VBG denotes following
T1360 1844-1850 NN denotes damage
T1359 1838-1843 NN denotes brain
T1358 1830-1837 JJ denotes further
T1357 1827-1829 IN denotes in
T1356 1820-1826 NN denotes result
T1355 1816-1819 NNP denotes ICH
T1354 1813-1815 IN denotes by
T1353 1805-1812 VBN denotes induced
T1352 1798-1804 NN denotes tissue
T1351 1792-1797 NN denotes brain
T1350 1788-1791 DT denotes the
T1349 1785-1787 IN denotes in
T1348 1775-1784 NNS denotes responses
T1347 1762-1774 JJ denotes inflammatory
T1346 1758-1761 CC denotes and
T1345 1743-1757 NN denotes excitotoxicity
T1344 1739-1742 DT denotes the
T1343 1737-1738 , denotes ,
T1342 1726-1737 RB denotes importantly
T1341 1721-1725 JJR denotes more
T1340 1719-1720 : denotes ;
T1339 1716-1719 NNP denotes ICH
T1338 1710-1715 IN denotes after
T1337 1703-1709 NN denotes damage
T1336 1697-1702 NN denotes brain
T1335 1689-1696 JJ denotes primary
T1334 1681-1688 VBZ denotes induces
T1333 1669-1680 NN denotes deformation
T1332 1662-1668 NN denotes tissue
T1331 1656-1661 NN denotes brain
T1330 1650-1655 JJ denotes Local
T1329 1648-1649 . denotes .
T1328 1647-1648 NNP denotes ]
T1327 1646-1647 CD denotes 2
T1326 1644-1645 , denotes ,
T1325 1643-1644 CD denotes 1
T1324 1642-1643 VBP denotes [
T1323 1632-1641 NNS denotes survivors
T1322 1629-1631 IN denotes in
T1321 1618-1628 NN denotes disability
T1320 1611-1617 JJ denotes severe
T1319 1607-1610 CC denotes and
T1318 1597-1606 NN denotes mortality
T1317 1592-1596 JJ denotes high
T1316 1587-1591 IN denotes with
T1315 1576-1586 VBN denotes associated
T1314 1573-1575 VBZ denotes is
T1313 1567-1572 WDT denotes which
T1312 1565-1566 , denotes ,
T1311 1559-1565 NN denotes stroke
T1310 1550-1558 JJ denotes ischemic
T1309 1547-1549 IN denotes of
T1308 1537-1546 NN denotes treatment
T1307 1524-1536 JJ denotes thrombolytic
T1306 1520-1523 DT denotes the
T1305 1517-1519 IN denotes of
T1304 1504-1516 NN denotes complication
T1303 1502-1503 DT denotes a
T1302 1499-1501 IN denotes as
T1301 1489-1498 NN denotes frequency
T1300 1478-1488 VBG denotes increasing
T1299 1473-1477 IN denotes with
T1298 1466-1472 VBZ denotes occurs
T1297 1462-1465 CC denotes and
T1296 1454-1461 NNS denotes strokes
T1295 1450-1453 DT denotes all
T1294 1447-1449 IN denotes of
T1293 1445-1446 NN denotes %
T1292 1443-1445 CD denotes 15
T1291 1441-1442 NN denotes %
T1290 1439-1441 CD denotes 10
T1289 1428-1438 VBZ denotes represents
T1288 1426-1427 -RRB- denotes )
T1287 1423-1426 NNP denotes ICH
T1286 1422-1423 -LRB- denotes (
T1285 1411-1421 NN denotes hemorrhage
T1284 1397-1410 NNP denotes Intracerebral
T1512 2741-2767 JJ denotes immunological/inflammatory
T1511 2738-2740 IN denotes of
T1510 2728-2737 NN denotes induction
T1509 2724-2727 DT denotes the
T1508 2721-2723 IN denotes in
T1507 2716-2720 NN denotes role
T1506 2707-2715 JJ denotes critical
T1505 2705-2706 DT denotes a
T1504 2700-2704 VBP denotes play
T1503 2695-2699 NNS denotes TLRs
T1502 2693-2694 . denotes .
T1501 2692-2693 NN denotes ]
T1500 2691-2692 CD denotes 6
T1499 2689-2690 , denotes ,
T1498 2688-2689 CD denotes 5
T1497 2687-2688 VBP denotes [
T1496 2677-2686 NNS denotes responses
T1495 2664-2676 JJ denotes inflammatory
T1494 2661-2663 TO denotes to
T1493 2653-2660 VBN denotes related
T1492 2647-2652 NNS denotes genes
T1491 2644-2646 IN denotes of
T1490 2630-2643 NN denotes transcription
T1489 2626-2629 DT denotes the
T1488 2616-2625 VBZ denotes regulates
T1487 2612-2615 CC denotes and
T1486 2602-2611 NNS denotes activates
T1485 2598-2601 CC denotes and
T1484 2590-2597 NN denotes nucleus
T1483 2586-2589 DT denotes the
T1482 2581-2585 IN denotes into
T1481 2567-2580 VBZ denotes trans-locates
T1480 2562-2566 NNP denotes NFκB
T1479 2560-2561 , denotes ,
T1478 2556-2560 RB denotes Then
T1477 2554-2555 . denotes .
T1476 2553-2554 -RRB- denotes )
T1475 2549-2553 NNP denotes NFκB
T1474 2548-2549 -LRB- denotes (
T1473 2537-2547 NNP denotes NF-kappa-B
T1472 2532-2536 IN denotes from
T1471 2528-2531 NNP denotes IκB
T1470 2516-2527 VBZ denotes dissociates
T1469 2512-2515 CC denotes and
T1468 2510-2511 -RRB- denotes )
T1467 2507-2510 NNP denotes IκB
T1466 2506-2507 -LRB- denotes (
T1465 2498-2505 NNP denotes kappa-B
T1464 2495-2497 IN denotes of
T1463 2485-2494 NN denotes inhibitor
T1462 2482-2484 IN denotes of
T1461 2466-2481 NN denotes phosphorylation
T1460 2462-2465 DT denotes the
T1459 2454-2461 VBZ denotes induces
T1458 2449-2453 CD denotes TLR4
T1457 2446-2448 IN denotes of
T1456 2435-2445 NN denotes activation
T1455 2431-2434 DT denotes the
T1454 2429-2430 , denotes ,
T1453 2423-2429 NN denotes ligand
T1452 2414-2422 JJ denotes specific
T1451 2409-2413 IN denotes with
T1450 2400-2408 VBN denotes combined
T1449 2398-2399 , denotes ,
T1448 2391-2398 NN denotes example
T1447 2387-2390 IN denotes For
T1446 2385-2386 . denotes .
T1445 2384-2385 NN denotes ]
T1444 2383-2384 CD denotes 6
T1443 2381-2382 , denotes ,
T1442 2380-2381 CD denotes 5
T1441 2379-2380 VBP denotes [
T1440 2369-2378 NNS denotes cytokines
T1439 2365-2368 CC denotes and
T1438 2355-2364 NNS denotes molecules
T1437 2331-2354 JJ denotes inflammation-associated
T1436 2322-2330 VBG denotes encoding
T1435 2316-2321 NNS denotes genes
T1434 2313-2315 IN denotes of
T1433 2299-2312 NN denotes transcription
T1432 2296-2298 IN denotes in
T1431 2288-2295 NNS denotes results
T1430 2284-2287 CC denotes and
T1429 2275-2283 NNS denotes proteins
T1428 2265-2274 VBG denotes signaling
T1427 2254-2264 JJ denotes downstream
T1426 2245-2253 VBZ denotes recruits
T1425 2240-2244 NNPS denotes TLRs
T1424 2237-2239 IN denotes of
T1423 2226-2236 NNP denotes Activation
T1422 2224-2225 . denotes .
T1421 2223-2224 NNP denotes ]
T1420 2222-2223 CD denotes 4
T1419 2221-2222 VBP denotes [
T1418 2211-2220 NNS denotes molecules
T1417 2198-2210 NN denotes transduction
T1416 2191-2197 NN denotes signal
T1415 2188-2190 IN denotes as
T1414 2184-2187 NN denotes act
T1413 2180-2183 CC denotes and
T1412 2171-2179 NNS denotes proteins
T1411 2157-2170 NN denotes transmembrane
T1410 2154-2156 IN denotes of
T1409 2147-2153 NN denotes family
T1408 2145-2146 DT denotes a
T1407 2141-2144 VBP denotes are
T1406 2136-2140 NNS denotes TLRs
T1405 2134-2135 . denotes .
T1404 2124-2134 VBN denotes elucidated
T1403 2121-2123 VB denotes be
T1402 2118-2120 TO denotes to
T1401 2110-2117 VBZ denotes remains
T1400 2100-2109 VBN denotes regulated
T1399 2096-2099 CC denotes and
T1398 2086-2095 VBN denotes triggered
T1397 2082-2085 VBP denotes are
T1396 2078-2081 NNP denotes ICH
T1395 2075-2077 IN denotes in
T1394 2065-2074 NNS denotes responses
T1393 2052-2064 JJ denotes inflammatory
T1392 2048-2051 DT denotes the
T1391 2044-2047 WRB denotes how
T1390 2042-2043 , denotes ,
T1389 2030-2042 RB denotes Nevertheless
T1388 2028-2029 . denotes .
T1387 2022-2028 NN denotes stroke
T1386 2013-2021 JJ denotes ischemic
T1385 2007-2012 IN denotes after
T1384 2000-2006 NN denotes injury
T1383 1994-1999 NN denotes brain
T1382 1991-1993 IN denotes of
T1381 1979-1990 NN denotes progression
T1380 1975-1978 DT denotes the
T1379 1972-1974 IN denotes in
T1378 1960-1971 VB denotes participate
T1377 1957-1959 TO denotes to
T1376 1951-1956 VBN denotes shown
T1375 1943-1950 RB denotes clearly
T1374 1938-1942 VBN denotes been
T1373 1933-1937 VBP denotes have
T1372 1922-1932 NNS denotes mechanisms
T1371 1895-1921 JJ denotes immunological/inflammatory
T1370 1886-1894 JJ denotes adaptive
T1369 1882-1885 CC denotes and
T1368 1875-1881 NN denotes innate
T1367 1870-1874 DT denotes Both
T1366 1868-1869 . denotes .
T570 1078-1079 -LRB- denotes (
T569 1074-1077 NNP denotes ICH
T568 1068-1073 IN denotes after
T567 1064-1067 NN denotes day
T566 1060-1063 JJ denotes 7th
T565 1056-1059 DT denotes the
T564 1053-1055 IN denotes on
T563 1047-1052 NN denotes level
T562 1040-1046 JJR denotes higher
T561 1038-1039 DT denotes a
T560 1035-1037 IN denotes at
T559 1024-1034 VBN denotes maintained
T558 1018-1023 RB denotes still
T557 1014-1017 CC denotes but
T556 1004-1013 VBD denotes decreased
T555 999-1003 RB denotes then
T554 995-998 CC denotes and
T553 993-994 , denotes ,
T552 990-993 NNP denotes ICH
T551 984-989 IN denotes after
T550 980-983 NN denotes day
T549 976-979 JJ denotes 3rd
T548 972-975 DT denotes the
T547 969-971 IN denotes on
T546 962-968 VBD denotes peaked
T545 960-961 , denotes ,
T544 957-960 NNP denotes ICH
T543 951-956 IN denotes after
T542 945-950 NNS denotes hours
T541 943-944 CD denotes 6
T540 940-942 IN denotes at
T539 931-939 VBG denotes starting
T538 921-930 VBD denotes increased
T537 907-920 RB denotes significantly
T536 899-906 NN denotes protein
T535 895-898 CC denotes and
T534 890-894 NNP denotes mRNA
T533 885-889 CD denotes TLR4
T532 881-884 DT denotes the
T531 879-880 , denotes ,
T530 872-879 NN denotes control
T529 865-871 NN denotes saline
T528 860-864 IN denotes with
T527 851-859 VBN denotes Compared
T526 849-850 . denotes .
T525 845-849 NNP denotes EMSA
T524 841-844 CC denotes and
T523 839-840 , denotes ,
T522 831-839 NN denotes staining
T521 810-830 NN denotes immunohistochemistry
T520 808-809 , denotes ,
T519 803-808 NNS denotes blots
T518 795-802 NNP denotes Western
T517 793-794 , denotes ,
T516 787-793 NNP denotes Rt-PCR
T515 784-786 IN denotes by
T514 777-783 NN denotes tissue
T513 768-776 JJ denotes cerebral
T512 756-767 JJ denotes hemorrhagic
T511 753-755 IN denotes in
T510 744-752 VBN denotes examined
T509 739-743 VBD denotes were
T508 734-738 NNP denotes NFκB
T507 731-733 IN denotes of
T506 722-730 NN denotes activity
T505 718-721 DT denotes the
T504 714-717 CC denotes and
T503 712-713 , denotes ,
T502 711-712 -RRB- denotes )
T501 705-711 NNP denotes p-IκBα
T500 704-705 -LRB- denotes (
T499 702-703 NNP denotes B
T498 696-701 NN denotes kappa
T497 693-695 IN denotes of
T496 682-692 NNS denotes inhibitors
T495 679-681 IN denotes of
T494 663-678 NN denotes phosphorylation
T493 659-662 DT denotes the
T492 657-658 , denotes ,
T491 650-657 NN denotes protein
T490 646-649 CC denotes and
T489 641-645 NNP denotes mRNA
T488 636-640 CD denotes TLR4
T487 634-635 . denotes .
T486 631-634 NNP denotes ICH
T485 625-630 IN denotes after
T484 620-624 NNS denotes rats
T483 613-619 NNP denotes Wistar
T482 610-612 IN denotes of
T481 602-609 NNS denotes tissues
T480 596-601 NN denotes brain
T479 593-595 IN denotes in
T478 583-592 VBG denotes signaling
T477 578-582 NNP denotes NFκB
T476 564-577 JJ denotes TLR4-mediated
T475 561-563 IN denotes of
T474 550-560 NN denotes activation
T473 546-549 DT denotes the
T472 542-545 CC denotes and
T471 537-541 CD denotes TLR4
T470 534-536 IN denotes of
T469 523-533 NN denotes expression
T468 519-522 DT denotes the
T467 516-518 IN denotes of
T466 508-515 NN denotes profile
T465 499-507 JJ denotes temporal
T464 495-498 DT denotes the
T463 486-494 VB denotes evaluate
T462 483-485 TO denotes to
T461 479-482 VBD denotes was
T460 473-478 NN denotes study
T459 465-472 JJ denotes present
T458 461-464 DT denotes The
T457 459-460 . denotes .
T456 452-459 JJ denotes unknown
T455 444-451 VBZ denotes remains
T454 440-443 NNP denotes ICH
T453 437-439 IN denotes of
T452 424-436 NN denotes pathogenesis
T451 420-423 DT denotes the
T450 417-419 IN denotes in
T449 407-416 VBG denotes signaling
T448 402-406 NNP denotes NFκB
T447 388-401 JJ denotes TLR4-mediated
T446 385-387 IN denotes of
T445 373-384 NN denotes involvement
T444 369-372 DT denotes the
T443 367-368 , denotes ,
T442 360-367 RB denotes However
T441 358-359 . denotes .
T440 353-358 NN denotes brain
T439 345-352 JJ denotes injured
T438 342-344 IN denotes in
T437 332-341 NNS denotes responses
T436 319-331 JJ denotes inflammatory
T435 316-318 IN denotes of
T434 305-315 NN denotes regulation
T433 301-304 CC denotes and
T432 290-300 NN denotes activation
T431 286-289 DT denotes the
T430 283-285 IN denotes in
T429 277-282 NNS denotes roles
T428 268-276 JJ denotes critical
T427 262-267 NNS denotes plays
T426 252-261 VBG denotes signaling
T425 250-251 -RRB- denotes )
T424 246-250 NNP denotes NFκB
T423 245-246 -LRB- denotes (
T422 237-244 NN denotes kappa-B
T421 230-236 NN denotes factor
T420 222-229 JJ denotes nuclear
T419 213-221 VBN denotes mediated
T418 211-212 -RRB- denotes )
T417 210-211 : denotes -
T416 206-210 SYM denotes TLR4
T415 205-206 -LRB- denotes (
T414 203-204 : denotes -
T413 202-203 LS denotes 4
T412 193-201 NN denotes receptor
T411 183-192 JJ denotes Toll-like
T410 181-182 . denotes .
T409 180-181 -RRB- denotes )
T408 177-180 NNP denotes ICH
T407 176-177 -LRB- denotes (
T406 165-175 NN denotes hemorrhage
T405 151-164 NNP denotes Intracerebral
T404 148-150 IN denotes of
T403 135-147 NN denotes pathogenesis
T402 131-134 DT denotes the
T401 128-130 IN denotes in
T400 123-127 NN denotes role
T399 115-122 JJ denotes crucial
T398 113-114 DT denotes a
T397 108-112 VBP denotes play
T396 99-107 NN denotes immunity
T395 95-98 CC denotes and
T394 82-94 NNP denotes Inflammation
T623 1378-1379 . denotes .
T622 1372-1378 NN denotes damage
T621 1366-1371 NN denotes brain
T620 1354-1365 JJ denotes ICH-induced
T619 1350-1353 IN denotes for
T618 1343-1349 NN denotes target
T617 1331-1342 JJ denotes therapeutic
T616 1329-1330 DT denotes a
T615 1322-1328 VB denotes become
T614 1318-1321 MD denotes may
T613 1312-1317 WDT denotes which
T612 1310-1311 , denotes ,
T611 1307-1310 NNP denotes ICH
T610 1304-1306 IN denotes of
T609 1291-1303 NN denotes pathogenesis
T608 1287-1290 DT denotes the
T607 1284-1286 IN denotes in
T606 1271-1283 VBZ denotes participates
T605 1261-1270 VBG denotes signaling
T604 1256-1260 NNP denotes NFκB
T603 1242-1255 JJ denotes TLR4-mediated
T602 1237-1241 IN denotes that
T601 1228-1236 VBZ denotes suggests
T600 1220-1227 RB denotes firstly
T599 1214-1219 NN denotes study
T598 1206-1213 JJ denotes present
T597 1202-1205 DT denotes The
T596 1200-1201 . denotes .
T595 1193-1200 NN denotes control
T594 1186-1192 NN denotes saline
T593 1181-1185 IN denotes with
T592 1172-1180 VBN denotes compared
T591 1168-1171 NNP denotes ICH
T590 1162-1167 IN denotes after
T589 1156-1161 NN denotes brain
T588 1152-1155 DT denotes the
T587 1149-1151 IN denotes in
T586 1139-1148 VBD denotes increased
T585 1134-1138 RB denotes also
T584 1129-1133 NNP denotes NFκB
T583 1126-1128 IN denotes of
T582 1117-1125 NN denotes activity
T581 1113-1116 DT denotes the
T580 1109-1112 CC denotes and
T579 1102-1108 NNP denotes p-IκBα
T578 1099-1101 IN denotes of
T577 1093-1098 NN denotes level
T576 1089-1092 DT denotes The
T575 1087-1088 . denotes .
T574 1086-1087 -RRB- denotes )
T573 1083-1086 CD denotes .05
T572 1081-1082 CD denotes <
T571 1079-1080 NNP denotes P
T5159 10579-10580 CD denotes <
T5083 10150-10153 CD denotes 3.2
T3675 7748-7749 . denotes .
T3674 7740-7748 NNS denotes controls
T3673 7731-7739 JJ denotes negative
T3672 7728-7730 IN denotes as
T3671 7721-7727 VBD denotes served
T3670 7710-7720 NNS denotes antibodies
T3669 7702-7709 JJ denotes primary
T3668 7694-7701 IN denotes without
T3667 7684-7693 VBN denotes processed
T3666 7677-7683 NNS denotes Slides
T3665 7675-7676 . denotes .
T3664 7674-7675 -RRB- denotes )
T3663 7672-7674 NNP denotes CA
T5167 10605-10608 NN denotes day
T5166 10601-10604 JJ denotes 3rd
T5165 10597-10600 DT denotes the
T5164 10594-10596 IN denotes on
T5163 10587-10593 VBD denotes peaked
T5162 10585-10586 , denotes ,
T5161 10584-10585 -RRB- denotes )
T5160 10581-10584 CD denotes .05
T5158 10577-10578 NNP denotes P
T5157 10576-10577 -LRB- denotes (
T5156 10572-10575 NNP denotes ICH
T5155 10566-10571 IN denotes after
T5154 10560-10565 NNS denotes hours
T1629 3403-3406 DT denotes the
T1628 3397-3402 IN denotes about
T1627 3387-3396 NN denotes knowledge
T1634 3432-3435 DT denotes the
T1633 3428-3431 CC denotes and
T1632 3423-3427 CD denotes TLR4
T1631 3420-3422 IN denotes of
T1630 3407-3419 NN denotes distribution
T1626 3383-3386 DT denotes the
T1625 3374-3382 VBD denotes provided
T1624 3366-3373 RB denotes firstly
T1623 3361-3365 NNS denotes data
T1622 3357-3360 PRP$ denotes Our
T1621 3355-3356 . denotes .
T1620 3352-3355 NNP denotes ICH
T1619 3339-3351 JJ denotes experimental
T1618 3336-3338 TO denotes to
T1617 3326-3335 VBN denotes subjected
T1616 3319-3325 NNS denotes brains
T1615 3315-3318 NN denotes rat
T1614 3311-3314 DT denotes the
T1613 3308-3310 IN denotes in
T1612 3298-3307 VBG denotes signaling
T4239 8783-8784 . denotes .
T4238 8776-8783 NNS denotes minutes
T4237 8773-8775 CD denotes 40
T4236 8770-8772 IN denotes of
T4235 8764-8769 NN denotes total
T4234 8762-8763 DT denotes a
T4233 8758-8761 IN denotes for
T4232 8756-8757 , denotes ,
T4231 8749-8756 NNS denotes minutes
T4230 8746-8748 CD denotes 10
T4229 8740-8745 DT denotes every
T4228 8732-8739 NNS denotes seconds
T4227 8729-8731 CD denotes 15
T4226 8725-8728 IN denotes for
T4225 8718-8724 NN denotes vortex
T4224 8715-8717 IN denotes on
T4223 8711-8714 VBN denotes put
T4222 8706-8710 VBD denotes were
T4221 8698-8705 NNS denotes pellets
T4220 8687-8697 VBG denotes containing
T4219 8681-8686 NNS denotes tubes
T7947 14149-14150 NNP denotes [
T7946 14145-14148 NNP denotes ICH
T7945 14142-14144 IN denotes by
T7944 14133-14141 VBN denotes produced
T7943 14126-14132 NN denotes damage
T7942 14117-14125 JJ denotes neuronal
T7941 14113-14116 CC denotes and
T7940 14111-14112 , denotes ,
T7939 14100-14111 NN denotes dysfunction
T7938 14089-14099 JJ denotes behavioral
T7937 14087-14088 , denotes ,
T7936 14075-14087 NN denotes inflammation
T7935 14068-14074 VB denotes reduce
T7934 14065-14067 IN denotes as
T7933 14060-14064 JJ denotes such
T7932 14058-14059 , denotes ,
T7931 14055-14058 NNP denotes ICH
T7930 14042-14054 JJ denotes experimental
T7929 14039-14041 IN denotes on
T7928 14032-14038 NN denotes effect
T7927 14020-14031 JJ denotes therapeutic
T7926 14018-14019 DT denotes a
T7925 14013-14017 VB denotes have
T7924 14010-14012 TO denotes to
T7923 14004-14009 VBN denotes shown
T7922 13999-14003 VBN denotes been
T7921 13995-13998 VBZ denotes has
T7920 13986-13994 NN denotes activity
T7919 13981-13985 NNP denotes NFκB
T7918 13978-13980 IN denotes of
T7917 13967-13977 NNP denotes Inhibition
T7916 13965-13966 . denotes .
T7915 13964-13965 NNP denotes ]
T7914 13962-13964 CD denotes 16
T7913 13961-13962 NNP denotes [
T7912 13957-13960 NNP denotes ICH
T7911 13951-13956 IN denotes after
T7910 13945-13950 NN denotes death
T7909 13940-13944 NN denotes cell
T7908 13927-13939 JJ denotes perilesional
T7907 13924-13926 IN denotes of
T7906 13911-13923 NN denotes pathobiology
T7905 13907-13910 DT denotes the
T7904 13904-13906 TO denotes to
R251 T384 T384 ROOT Activation,Activation
R252 T385 T384 prep of,Activation
R253 T386 T387 compound TLR4-Mediated,NFκB
R254 T387 T385 pobj NFκB,of
R255 T388 T384 acl Signaling,Activation
R256 T389 T388 prep in,Signaling
R257 T390 T391 compound Hemorrhagic,Brain
R258 T391 T389 pobj Brain,in
R259 T392 T391 prep in,Brain
R260 T393 T394 compound Rats,Inflammation
R261 T394 T392 pobj Inflammation,in
R262 T395 T391 cc and,Brain
R263 T396 T397 nsubj immunity,play
R264 T397 T388 ccomp play,Signaling
R265 T398 T400 det a,role
R266 T399 T400 amod crucial,role
R267 T400 T397 dobj role,play
R268 T401 T397 prep in,play
R269 T402 T403 det the,pathogenesis
R270 T403 T401 pobj pathogenesis,in
R271 T404 T403 prep of,pathogenesis
R272 T405 T406 compound Intracerebral,hemorrhage
R273 T406 T404 pobj hemorrhage,of
R274 T407 T408 punct (,ICH
R275 T408 T406 appos ICH,hemorrhage
R276 T409 T384 punct ),Activation
R277 T410 T384 punct .,Activation
R278 T411 T412 amod Toll-like,receptor
R279 T412 T412 ROOT receptor,receptor
R280 T413 T419 meta 4,mediated
R281 T414 T413 punct -,4
R282 T415 T419 punct (,mediated
R283 T416 T419 ccomp TLR4,mediated
R284 T417 T416 punct -,TLR4
R285 T418 T419 punct ),mediated
R286 T419 T422 amod mediated,kappa-B
R287 T420 T421 amod nuclear,factor
R288 T421 T422 compound factor,kappa-B
R289 T422 T412 appos kappa-B,receptor
R290 T423 T422 punct (,kappa-B
R291 T424 T422 appos NFκB,kappa-B
R292 T425 T422 punct ),kappa-B
R293 T426 T412 acl signaling,receptor
R294 T427 T426 dobj plays,signaling
R295 T428 T429 amod critical,roles
R296 T429 T427 dobj roles,plays
R297 T430 T427 prep in,plays
R298 T431 T432 det the,activation
R299 T432 T430 pobj activation,in
R300 T433 T432 cc and,activation
R301 T434 T432 conj regulation,activation
R302 T435 T434 prep of,regulation
R303 T436 T437 amod inflammatory,responses
R304 T437 T435 pobj responses,of
R305 T438 T437 prep in,responses
R306 T439 T440 amod injured,brain
R307 T440 T438 pobj brain,in
R308 T441 T412 punct .,receptor
R309 T442 T455 advmod However,remains
R310 T443 T455 punct ",",remains
R311 T444 T445 det the,involvement
R312 T445 T455 nsubj involvement,remains
R313 T446 T445 prep of,involvement
R314 T447 T448 compound TLR4-mediated,NFκB
R315 T448 T446 pobj NFκB,of
R316 T449 T445 acl signaling,involvement
R317 T450 T449 prep in,signaling
R318 T451 T452 det the,pathogenesis
R319 T452 T450 pobj pathogenesis,in
R320 T453 T452 prep of,pathogenesis
R321 T454 T453 pobj ICH,of
R322 T455 T455 ROOT remains,remains
R323 T456 T455 acomp unknown,remains
R324 T457 T455 punct .,remains
R325 T458 T460 det The,study
R326 T459 T460 amod present,study
R327 T460 T461 nsubj study,was
R328 T461 T461 ROOT was,was
R329 T462 T463 aux to,evaluate
R330 T463 T461 xcomp evaluate,was
R331 T464 T466 det the,profile
R332 T465 T466 amod temporal,profile
R333 T466 T463 dobj profile,evaluate
R334 T467 T466 prep of,profile
R335 T468 T469 det the,expression
R336 T469 T467 pobj expression,of
R337 T470 T469 prep of,expression
R338 T471 T470 pobj TLR4,of
R339 T472 T469 cc and,expression
R340 T473 T474 det the,activation
R341 T474 T469 conj activation,expression
R342 T475 T474 prep of,activation
R343 T476 T477 compound TLR4-mediated,NFκB
R344 T477 T475 pobj NFκB,of
R345 T478 T466 acl signaling,profile
R346 T479 T478 prep in,signaling
R347 T480 T481 compound brain,tissues
R348 T481 T479 pobj tissues,in
R349 T482 T481 prep of,tissues
R350 T483 T484 compound Wistar,rats
R351 T484 T482 pobj rats,of
R352 T485 T463 prep after,evaluate
R353 T486 T485 pobj ICH,after
R354 T487 T461 punct .,was
R355 T488 T489 nummod TLR4,mRNA
R356 T489 T510 nsubjpass mRNA,examined
R357 T490 T489 cc and,mRNA
R358 T491 T489 conj protein,mRNA
R359 T492 T491 punct ",",protein
R360 T493 T494 det the,phosphorylation
R361 T494 T491 appos phosphorylation,protein
R362 T495 T494 prep of,phosphorylation
R363 T496 T495 pobj inhibitors,of
R364 T497 T496 prep of,inhibitors
R365 T498 T499 compound kappa,B
R366 T499 T497 pobj B,of
R367 T500 T499 punct (,B
R368 T501 T499 appos p-IκBα,B
R369 T502 T499 punct ),B
R370 T503 T494 punct ",",phosphorylation
R371 T504 T494 cc and,phosphorylation
R372 T505 T506 det the,activity
R373 T506 T494 conj activity,phosphorylation
R374 T507 T506 prep of,activity
R375 T508 T507 pobj NFκB,of
R376 T509 T510 auxpass were,examined
R377 T510 T510 ROOT examined,examined
R378 T511 T510 prep in,examined
R379 T512 T514 amod hemorrhagic,tissue
R380 T513 T514 amod cerebral,tissue
R381 T514 T511 pobj tissue,in
R382 T515 T510 agent by,examined
R383 T516 T515 pobj Rt-PCR,by
R384 T517 T516 punct ",",Rt-PCR
R385 T518 T519 amod Western,blots
R386 T519 T510 npadvmod blots,examined
R387 T520 T519 punct ",",blots
R388 T521 T522 compound immunohistochemistry,staining
R389 T522 T519 conj staining,blots
R390 T523 T522 punct ",",staining
R391 T524 T522 cc and,staining
R392 T525 T522 conj EMSA,staining
R393 T526 T510 punct .,examined
R394 T527 T538 prep Compared,increased
R395 T528 T527 prep with,Compared
R396 T529 T530 compound saline,control
R397 T530 T528 pobj control,with
R398 T531 T530 punct ",",control
R399 T532 T534 det the,mRNA
R400 T533 T534 nummod TLR4,mRNA
R401 T534 T530 conj mRNA,control
R402 T535 T534 cc and,mRNA
R403 T536 T534 conj protein,mRNA
R404 T537 T538 advmod significantly,increased
R405 T538 T538 ROOT increased,increased
R406 T539 T538 xcomp starting,increased
R407 T540 T539 prep at,starting
R408 T541 T542 nummod 6,hours
R409 T542 T540 pobj hours,at
R410 T543 T546 mark after,peaked
R411 T544 T543 pobj ICH,after
R412 T545 T546 punct ",",peaked
R413 T546 T538 advcl peaked,increased
R414 T547 T546 prep on,peaked
R415 T548 T550 det the,day
R416 T549 T550 amod 3rd,day
R417 T550 T547 pobj day,on
R418 T551 T550 prep after,day
R419 T552 T551 pobj ICH,after
R420 T553 T546 punct ",",peaked
R421 T554 T546 cc and,peaked
R422 T555 T556 advmod then,decreased
R423 T556 T546 conj decreased,peaked
R424 T557 T556 cc but,decreased
R425 T558 T559 advmod still,maintained
R426 T559 T556 conj maintained,decreased
R427 T560 T559 prep at,maintained
R428 T561 T563 det a,level
R429 T562 T563 amod higher,level
R430 T563 T560 pobj level,at
R431 T564 T563 prep on,level
R432 T565 T567 det the,day
R433 T566 T567 amod 7th,day
R434 T567 T564 pobj day,on
R435 T568 T567 prep after,day
R436 T569 T574 nmod ICH,)
R437 T570 T571 punct (,P
R438 T571 T574 nmod P,)
R439 T572 T571 nummod <,P
R440 T573 T571 nummod .05,P
R441 T574 T563 punct ),level
R442 T575 T538 punct .,increased
R443 T576 T577 det The,level
R444 T577 T586 nsubj level,increased
R445 T578 T577 prep of,level
R446 T579 T578 pobj p-IκBα,of
R447 T580 T579 cc and,p-IκBα
R448 T581 T582 det the,activity
R449 T582 T579 conj activity,p-IκBα
R450 T583 T582 prep of,activity
R451 T584 T583 pobj NFκB,of
R452 T585 T586 advmod also,increased
R453 T586 T586 ROOT increased,increased
R454 T587 T586 prep in,increased
R455 T588 T589 det the,brain
R456 T589 T587 pobj brain,in
R457 T590 T592 mark after,compared
R458 T591 T592 nsubj ICH,compared
R459 T592 T586 prep compared,increased
R460 T593 T592 prep with,compared
R461 T594 T595 amod saline,control
R462 T595 T593 pobj control,with
R463 T596 T586 punct .,increased
R464 T597 T599 det The,study
R465 T598 T599 amod present,study
R466 T599 T601 nsubj study,suggests
R467 T600 T601 advmod firstly,suggests
R468 T601 T601 ROOT suggests,suggests
R469 T602 T606 mark that,participates
R470 T603 T604 compound TLR4-mediated,NFκB
R471 T604 T606 nsubj NFκB,participates
R472 T605 T604 acl signaling,NFκB
R473 T606 T601 ccomp participates,suggests
R474 T607 T606 prep in,participates
R475 T608 T609 det the,pathogenesis
R476 T609 T607 pobj pathogenesis,in
R477 T610 T609 prep of,pathogenesis
R478 T611 T610 pobj ICH,of
R479 T612 T611 punct ",",ICH
R480 T613 T615 nsubj which,become
R481 T614 T615 aux may,become
R482 T615 T611 relcl become,ICH
R483 T616 T618 det a,target
R484 T617 T618 amod therapeutic,target
R485 T618 T615 attr target,become
R486 T619 T618 prep for,target
R487 T620 T622 amod ICH-induced,damage
R488 T621 T622 compound brain,damage
R489 T622 T619 pobj damage,for
R490 T623 T601 punct .,suggests
R923 T1284 T1285 compound Intracerebral,hemorrhage
R924 T1285 T1289 nsubj hemorrhage,represents
R925 T1286 T1287 punct (,ICH
R926 T1287 T1285 appos ICH,hemorrhage
R927 T1288 T1285 punct ),hemorrhage
R928 T1289 T1289 ROOT represents,represents
R929 T1290 T1291 nummod 10,%
R930 T1291 T1289 dobj %,represents
R931 T1292 T1293 nummod 15,%
R932 T1293 T1289 npadvmod %,represents
R933 T1294 T1293 prep of,%
R934 T1295 T1296 det all,strokes
R935 T1296 T1294 pobj strokes,of
R936 T1297 T1289 cc and,represents
R937 T1298 T1289 conj occurs,represents
R938 T1299 T1298 prep with,occurs
R939 T1300 T1301 amod increasing,frequency
R940 T1301 T1299 pobj frequency,with
R941 T1302 T1301 prep as,frequency
R942 T1303 T1304 det a,complication
R943 T1304 T1302 pobj complication,as
R944 T1305 T1304 prep of,complication
R945 T1306 T1308 det the,treatment
R946 T1307 T1308 compound thrombolytic,treatment
R947 T1308 T1305 pobj treatment,of
R948 T1309 T1308 prep of,treatment
R949 T1310 T1311 amod ischemic,stroke
R950 T1311 T1309 pobj stroke,of
R951 T1312 T1308 punct ",",treatment
R952 T1313 T1315 nsubjpass which,associated
R953 T1314 T1315 auxpass is,associated
R954 T1315 T1308 relcl associated,treatment
R955 T1316 T1315 prep with,associated
R956 T1317 T1318 amod high,mortality
R957 T1318 T1316 pobj mortality,with
R958 T1319 T1318 cc and,mortality
R959 T1320 T1321 amod severe,disability
R960 T1321 T1318 conj disability,mortality
R961 T1322 T1318 prep in,mortality
R962 T1323 T1322 pobj survivors,in
R963 T1324 T1328 nmod [,]
R964 T1325 T1324 nummod 1,[
R965 T1326 T1324 punct ",",[
R966 T1327 T1328 nummod 2,]
R967 T1328 T1298 npadvmod ],occurs
R968 T1329 T1289 punct .,represents
R969 T1330 T1333 amod Local,deformation
R970 T1331 T1332 compound brain,tissue
R971 T1332 T1333 compound tissue,deformation
R972 T1333 T1334 nsubj deformation,induces
R973 T1334 T1334 ROOT induces,induces
R974 T1335 T1337 amod primary,damage
R975 T1336 T1337 compound brain,damage
R976 T1337 T1334 dobj damage,induces
R977 T1338 T1337 prep after,damage
R978 T1339 T1338 pobj ICH,after
R979 T1340 T1345 punct ;,excitotoxicity
R980 T1341 T1342 advmod more,importantly
R981 T1342 T1345 advmod importantly,excitotoxicity
R982 T1343 T1345 punct ",",excitotoxicity
R983 T1344 T1345 det the,excitotoxicity
R984 T1345 T1334 dep excitotoxicity,induces
R985 T1346 T1345 cc and,excitotoxicity
R986 T1347 T1348 amod inflammatory,responses
R987 T1348 T1345 conj responses,excitotoxicity
R988 T1349 T1348 prep in,responses
R989 T1350 T1352 det the,tissue
R990 T1351 T1352 compound brain,tissue
R991 T1352 T1349 pobj tissue,in
R992 T1353 T1352 acl induced,tissue
R993 T1354 T1353 agent by,induced
R994 T1355 T1356 compound ICH,result
R995 T1356 T1354 pobj result,by
R996 T1357 T1353 prep in,induced
R997 T1358 T1360 amod further,damage
R998 T1359 T1360 compound brain,damage
R999 T1360 T1357 pobj damage,in
R1000 T1361 T1360 prep following,damage
R1001 T1362 T1363 compound ICH,[
R1002 T1363 T1365 nmod [,]
R1003 T1364 T1365 nummod 3,]
R1004 T1365 T1361 pobj ],following
R1005 T1366 T1334 punct .,induces
R1006 T1367 T1368 preconj Both,innate
R1007 T1368 T1376 nsubjpass innate,shown
R1008 T1369 T1368 cc and,innate
R1009 T1370 T1372 amod adaptive,mechanisms
R1010 T1371 T1372 amod immunological/inflammatory,mechanisms
R1011 T1372 T1368 conj mechanisms,innate
R1012 T1373 T1376 aux have,shown
R1013 T1374 T1376 auxpass been,shown
R1014 T1375 T1376 advmod clearly,shown
R1015 T1376 T1376 ROOT shown,shown
R1016 T1377 T1378 aux to,participate
R1017 T1378 T1376 xcomp participate,shown
R1018 T1379 T1378 prep in,participate
R1019 T1380 T1381 det the,progression
R1020 T1381 T1379 pobj progression,in
R1021 T1382 T1381 prep of,progression
R1022 T1383 T1384 compound brain,injury
R1023 T1384 T1382 pobj injury,of
R1024 T1385 T1378 prep after,participate
R1025 T1386 T1387 amod ischemic,stroke
R1026 T1387 T1385 pobj stroke,after
R1027 T1388 T1376 punct .,shown
R1028 T1389 T1398 advmod Nevertheless,triggered
R1029 T1390 T1398 punct ",",triggered
R1030 T1391 T1398 advmod how,triggered
R1031 T1392 T1394 det the,responses
R1032 T1393 T1394 amod inflammatory,responses
R1033 T1394 T1398 nsubjpass responses,triggered
R1034 T1395 T1394 prep in,responses
R1035 T1396 T1395 pobj ICH,in
R1036 T1397 T1398 auxpass are,triggered
R1037 T1398 T1398 ROOT triggered,triggered
R1038 T1399 T1398 cc and,triggered
R1039 T1400 T1398 conj regulated,triggered
R1040 T1401 T1398 conj remains,triggered
R1041 T1402 T1404 aux to,elucidated
R1042 T1403 T1404 auxpass be,elucidated
R1043 T1404 T1401 xcomp elucidated,remains
R1044 T1405 T1398 punct .,triggered
R1045 T1406 T1407 nsubj TLRs,are
R1046 T1407 T1407 ROOT are,are
R1047 T1408 T1409 det a,family
R1048 T1409 T1407 attr family,are
R1049 T1410 T1409 prep of,family
R1050 T1411 T1412 compound transmembrane,proteins
R1051 T1412 T1410 pobj proteins,of
R1052 T1413 T1409 cc and,family
R1053 T1414 T1409 conj act,family
R1054 T1415 T1419 mark as,[
R1055 T1416 T1418 compound signal,molecules
R1056 T1417 T1418 compound transduction,molecules
R1057 T1418 T1419 nsubj molecules,[
R1058 T1419 T1407 advcl [,are
R1059 T1420 T1421 nummod 4,]
R1060 T1421 T1419 dobj ],[
R1061 T1422 T1407 punct .,are
R1062 T1423 T1426 nsubj Activation,recruits
R1063 T1424 T1423 prep of,Activation
R1064 T1425 T1424 pobj TLRs,of
R1065 T1426 T1426 ROOT recruits,recruits
R1066 T1427 T1429 amod downstream,proteins
R1067 T1428 T1429 amod signaling,proteins
R1068 T1429 T1426 dobj proteins,recruits
R1069 T1430 T1429 cc and,proteins
R1070 T1431 T1429 conj results,proteins
R1071 T1432 T1431 prep in,results
R1072 T1433 T1432 pobj transcription,in
R1073 T1434 T1433 prep of,transcription
R1074 T1435 T1434 pobj genes,of
R1075 T1436 T1435 acl encoding,genes
R1076 T1437 T1438 amod inflammation-associated,molecules
R1077 T1438 T1436 dobj molecules,encoding
R1078 T1439 T1438 cc and,molecules
R1079 T1440 T1438 conj cytokines,molecules
R1080 T1441 T1445 nmod [,]
R1081 T1442 T1441 nummod 5,[
R1082 T1443 T1444 punct ",",6
R1083 T1444 T1445 nummod 6,]
R1084 T1445 T1426 npadvmod ],recruits
R1085 T1446 T1426 punct .,recruits
R1086 T1447 T1459 prep For,induces
R1087 T1448 T1447 pobj example,For
R1088 T1449 T1459 punct ",",induces
R1089 T1450 T1459 advcl combined,induces
R1090 T1451 T1450 prep with,combined
R1091 T1452 T1453 amod specific,ligand
R1092 T1453 T1451 pobj ligand,with
R1093 T1454 T1453 punct ",",ligand
R1094 T1455 T1456 det the,activation
R1095 T1456 T1459 nsubj activation,induces
R1096 T1457 T1456 prep of,activation
R1097 T1458 T1457 pobj TLR4,of
R1098 T1459 T1459 ROOT induces,induces
R1099 T1460 T1461 det the,phosphorylation
R1100 T1461 T1459 dobj phosphorylation,induces
R1101 T1462 T1461 prep of,phosphorylation
R1102 T1463 T1462 pobj inhibitor,of
R1103 T1464 T1463 prep of,inhibitor
R1104 T1465 T1464 pobj kappa-B,of
R1105 T1466 T1465 punct (,kappa-B
R1106 T1467 T1465 appos IκB,kappa-B
R1107 T1468 T1465 punct ),kappa-B
R1108 T1469 T1459 cc and,induces
R1109 T1470 T1459 conj dissociates,induces
R1110 T1471 T1470 dobj IκB,dissociates
R1111 T1472 T1471 prep from,IκB
R1112 T1473 T1472 pobj NF-kappa-B,from
R1113 T1474 T1473 punct (,NF-kappa-B
R1114 T1475 T1473 appos NFκB,NF-kappa-B
R1115 T1476 T1473 punct ),NF-kappa-B
R1116 T1477 T1459 punct .,induces
R1117 T1478 T1481 advmod Then,trans-locates
R1118 T1479 T1481 punct ",",trans-locates
R1119 T1480 T1481 nsubj NFκB,trans-locates
R1120 T1481 T1481 ROOT trans-locates,trans-locates
R1121 T1482 T1481 prep into,trans-locates
R1122 T1483 T1484 det the,nucleus
R1123 T1484 T1482 pobj nucleus,into
R1124 T1485 T1481 cc and,trans-locates
R1125 T1486 T1481 conj activates,trans-locates
R1126 T1487 T1486 cc and,activates
R1127 T1488 T1486 conj regulates,activates
R1128 T1489 T1490 det the,transcription
R1129 T1490 T1488 dobj transcription,regulates
R1130 T1491 T1490 prep of,transcription
R1131 T1492 T1491 pobj genes,of
R1132 T1493 T1492 acl related,genes
R1133 T1494 T1493 prep to,related
R1134 T1495 T1496 amod inflammatory,responses
R1135 T1496 T1494 pobj responses,to
R1136 T1497 T1496 amod [,responses
R1137 T1498 T1501 nummod 5,]
R1138 T1499 T1500 punct ",",6
R1139 T1500 T1501 nummod 6,]
R1140 T1501 T1497 appos ],[
R1141 T1502 T1486 punct .,activates
R1142 T1503 T1504 nsubj TLRs,play
R1143 T1504 T1504 ROOT play,play
R1144 T1505 T1507 det a,role
R1145 T1506 T1507 amod critical,role
R1146 T1507 T1504 dobj role,play
R1147 T1508 T1504 prep in,play
R1148 T1509 T1510 det the,induction
R1149 T1510 T1508 pobj induction,in
R1150 T1511 T1510 prep of,induction
R1151 T1512 T1513 amod immunological/inflammatory,responses
R1152 T1513 T1511 pobj responses,of
R1153 T1514 T1504 cc and,play
R1154 T1515 T1516 auxpass are,implicated
R1155 T1516 T1504 conj implicated,play
R1156 T1517 T1516 prep in,implicated
R1157 T1518 T1520 amod several,diseases
R1158 T1519 T1520 compound CNS,diseases
R1159 T1520 T1517 pobj diseases,in
R1160 T1521 T1520 punct ",",diseases
R1161 T1522 T1523 amod such,as
R1162 T1523 T1520 prep as,diseases
R1163 T1524 T1525 amod infectious,disease
R1164 T1525 T1523 pobj disease,as
R1165 T1526 T1525 punct ",",disease
R1166 T1527 T1528 amod autoimmune,disease
R1167 T1528 T1525 conj disease,disease
R1168 T1529 T1528 punct ",",disease
R1169 T1530 T1528 cc and,disease
R1170 T1531 T1534 amod ischemic,[
R1171 T1532 T1533 compound brain,injury
R1172 T1533 T1534 compound injury,[
R1173 T1534 T1528 conj [,disease
R1174 T1535 T1534 nummod 7,[
R1175 T1536 T1534 punct ",",[
R1176 T1537 T1538 nummod 8,]
R1177 T1538 T1534 appos ],[
R1178 T1539 T1504 punct .,play
R1179 T1540 T1541 amod Accumulating,evidences
R1180 T1541 T1542 nsubj evidences,demonstrate
R1181 T1542 T1542 ROOT demonstrate,demonstrate
R1182 T1543 T1552 mark that,contributes
R1183 T1544 T1552 nsubj TLR4,contributes
R1184 T1545 T1544 punct ",",TLR4
R1185 T1546 T1550 det the,recognized
R1186 T1547 T1550 amod first,recognized
R1187 T1548 T1550 npadvmod mammalian,recognized
R1188 T1549 T1550 nsubj TLR,recognized
R1189 T1550 T1552 nsubj recognized,contributes
R1190 T1551 T1552 punct ",",contributes
R1191 T1552 T1542 ccomp contributes,demonstrate
R1192 T1553 T1552 prep to,contributes
R1193 T1554 T1556 det the,death
R1194 T1555 T1556 amod neuronal,death
R1195 T1556 T1553 pobj death,to
R1196 T1557 T1556 punct ",",death
R1197 T1558 T1559 compound blood,brain
R1198 T1559 T1561 compound brain,damage
R1199 T1560 T1561 compound barrier,damage
R1200 T1561 T1556 appos damage,death
R1201 T1562 T1561 punct ",",damage
R1202 T1563 T1564 compound brain,edema
R1203 T1564 T1561 conj edema,damage
R1204 T1565 T1564 punct ",",edema
R1205 T1566 T1564 cc and,edema
R1206 T1567 T1568 amod inflammatory,responses
R1207 T1568 T1564 conj responses,edema
R1208 T1569 T1568 prep in,responses
R1209 T1570 T1572 det the,injury
R1210 T1571 T1572 compound brain,injury
R1211 T1572 T1569 pobj injury,in
R1212 T1573 T1572 acl induced,injury
R1213 T1574 T1573 agent by,induced
R1214 T1575 T1576 compound ischemia,[
R1215 T1576 T1580 nmod [,]
R1216 T1577 T1576 nummod 8,[
R1217 T1578 T1580 punct ",",]
R1218 T1579 T1580 nummod 9,]
R1219 T1580 T1561 appos ],damage
R1220 T1581 T1542 punct .,demonstrate
R1221 T1582 T1586 advmod However,known
R1222 T1583 T1586 punct ",",known
R1223 T1584 T1586 advmod little,known
R1224 T1585 T1586 auxpass is,known
R1225 T1586 T1586 ROOT known,known
R1226 T1587 T1586 prep about,known
R1227 T1588 T1587 pobj TLR4,about
R1228 T1589 T1588 prep in,TLR4
R1229 T1590 T1591 det the,brain
R1230 T1591 T1589 pobj brain,in
R1231 T1592 T1586 prep after,known
R1232 T1593 T1592 pobj ICH,after
R1233 T1594 T1586 punct .,known
R1234 T1595 T1601 prep In,detected
R1235 T1596 T1598 det the,study
R1236 T1597 T1598 amod present,study
R1237 T1598 T1595 pobj study,In
R1238 T1599 T1601 punct ",",detected
R1239 T1600 T1601 nsubj we,detected
R1240 T1601 T1601 ROOT detected,detected
R1241 T1602 T1603 det the,transcription
R1242 T1603 T1601 dobj transcription,detected
R1243 T1604 T1603 prep of,transcription
R1244 T1605 T1606 nummod TLR4,gene
R1245 T1606 T1604 pobj gene,of
R1246 T1607 T1603 cc and,transcription
R1247 T1608 T1609 det the,activation
R1248 T1609 T1603 conj activation,transcription
R1249 T1610 T1609 prep of,activation
R1250 T1611 T1612 amod TLR4-mediated,signaling
R1251 T1612 T1610 pobj signaling,of
R1252 T1613 T1609 prep in,activation
R1253 T1614 T1616 det the,brains
R1254 T1615 T1616 compound rat,brains
R1255 T1616 T1613 pobj brains,in
R1256 T1617 T1603 acl subjected,transcription
R1257 T1618 T1617 prep to,subjected
R1258 T1619 T1620 amod experimental,ICH
R1259 T1620 T1618 pobj ICH,to
R1260 T1621 T1601 punct .,detected
R1261 T1622 T1623 poss Our,data
R1262 T1623 T1625 nsubj data,provided
R1263 T1624 T1625 advmod firstly,provided
R1264 T1625 T1625 ROOT provided,provided
R1265 T1626 T1627 det the,knowledge
R1266 T1627 T1625 dobj knowledge,provided
R1267 T1628 T1627 prep about,knowledge
R1268 T1629 T1630 det the,distribution
R1269 T1630 T1628 pobj distribution,about
R1270 T1631 T1630 prep of,distribution
R1534 T1989 T1989 ROOT 2.1,2.1
R1535 T1990 T1989 punct .,2.1
R1536 T1991 T2008 nsubjpass Animals,provided
R1537 T1992 T1994 nummod Ninety,rats
R1538 T1993 T1994 compound Wister,rats
R1539 T1994 T2008 nsubjpass rats,provided
R1540 T1995 T1994 punct (,rats
R1541 T1996 T1999 amod male,weight
R1542 T1997 T1999 punct ",",weight
R1543 T1998 T1999 compound body,weight
R1544 T1999 T1994 appos weight,rats
R1545 T2000 T1999 punct :,weight
R1546 T2001 T2002 meta 250,g
R1547 T2002 T1999 appos g,weight
R1548 T2003 T2002 prep to,g
R1549 T2004 T2005 nummod 300,g
R1550 T2005 T2003 pobj g,to
R1551 T2006 T1999 punct ),weight
R1552 T2007 T2008 auxpass were,provided
R1553 T2008 T2008 ROOT provided,provided
R1554 T2009 T2008 agent by,provided
R1555 T2010 T2012 compound Experimental,Center
R1556 T2011 T2012 compound Animal,Center
R1557 T2012 T2009 pobj Center,by
R1558 T2013 T2012 punct ",",Center
R1559 T2014 T2016 compound China,University
R1560 T2015 T2016 compound Medical,University
R1561 T2016 T2012 conj University,Center
R1562 T2017 T2008 punct .,provided
R1563 T2018 T2019 det The,rats
R1564 T2019 T2021 nsubjpass rats,assigned
R1565 T2020 T2021 auxpass were,assigned
R1566 T2021 T2021 ROOT assigned,assigned
R1567 T2022 T2021 advmod randomly,assigned
R1568 T2023 T2021 prep to,assigned
R1569 T2024 T2025 nummod three,groups
R1570 T2025 T2023 pobj groups,to
R1571 T2026 T2025 punct :,groups
R1572 T2027 T2028 amod normal,group
R1573 T2028 T2025 appos group,groups
R1574 T2029 T2030 punct (,N
R1575 T2030 T2028 appos N,group
R1576 T2031 T2028 punct ",",group
R1577 T2032 T2052 dep n,injection
R1578 T2033 T2034 punct =,10
R1579 T2034 T2032 prep 10,n
R1580 T2035 T2032 punct ",",n
R1581 T2036 T2032 prep without,n
R1582 T2037 T2038 det any,treatment
R1583 T2038 T2036 pobj treatment,without
R1584 T2039 T2032 punct ),n
R1585 T2040 T2032 punct ",",n
R1586 T2041 T2043 amod normal,control
R1587 T2042 T2043 amod saline,control
R1588 T2043 T2032 dobj control,n
R1589 T2044 T2045 punct (,S
R1590 T2045 T2052 dep S,injection
R1591 T2046 T2052 punct ",",injection
R1592 T2047 T2052 nmod n,injection
R1593 T2048 T2049 punct =,40
R1594 T2049 T2047 prep 40,n
R1595 T2050 T2052 punct ",",injection
R1596 T2051 T2052 amod intra-cerebral,injection
R1597 T2052 T2064 nmod injection,ICH
R1598 T2053 T2052 prep of,injection
R1599 T2054 T2055 amod normal,saline
R1600 T2055 T2053 pobj saline,of
R1601 T2056 T2052 prep as,injection
R1602 T2057 T2056 pobj control,as
R1603 T2058 T2052 punct ),injection
R1604 T2059 T2052 cc and,injection
R1605 T2060 T2062 amod intra-cerebral,group
R1606 T2061 T2062 compound hemorrhage,group
R1607 T2062 T2052 conj group,injection
R1608 T2063 T2064 punct (,ICH
R1609 T2064 T2028 appos ICH,group
R1610 T2065 T2064 punct ",",ICH
R1611 T2066 T2064 conj n,ICH
R1612 T2067 T2068 punct =,40
R1613 T2068 T2066 prep 40,n
R1614 T2069 T2066 punct ),n
R1615 T2070 T2021 punct .,assigned
R1616 T2071 T2073 det The,protocol
R1617 T2072 T2073 amod experimental,protocol
R1618 T2073 T2078 nsubjpass protocol,approved
R1619 T2074 T2073 acl used,protocol
R1620 T2075 T2074 prep for,used
R1621 T2076 T2075 pobj animals,for
R1622 T2077 T2078 auxpass was,approved
R1623 T2078 T2078 ROOT approved,approved
R1624 T2079 T2078 agent by,approved
R1625 T2080 T2085 det the,Committee
R1626 T2081 T2082 compound Animal,Care
R1627 T2082 T2085 nmod Care,Committee
R1628 T2083 T2082 cc and,Care
R1629 T2084 T2085 compound Use,Committee
R1630 T2085 T2079 pobj Committee,by
R1631 T2086 T2085 punct ",",Committee
R1632 T2087 T2089 compound China,University
R1633 T2088 T2089 compound Medical,University
R1634 T2089 T2085 conj University,Committee
R1635 T2090 T2078 punct .,approved
R1636 T2091 T2092 det The,rats
R1637 T2092 T2094 nsubjpass rats,subjected
R1638 T2093 T2094 auxpass were,subjected
R1639 T2094 T2094 ROOT subjected,subjected
R1640 T2095 T2094 prep to,subjected
R1641 T2096 T2097 amod intra-cerebral,injection
R1642 T2097 T2095 pobj injection,to
R1643 T2098 T2097 prep of,injection
R1644 T2099 T2100 amod normal,saline
R1645 T2100 T2104 nmod saline,blood
R1646 T2101 T2100 cc or,saline
R1647 T2102 T2100 conj autologous,saline
R1648 T2103 T2104 amod whole,blood
R1649 T2104 T2098 pobj blood,of
R1650 T2105 T2094 cc and,subjected
R1651 T2106 T2107 auxpass were,sacrificed
R1652 T2107 T2094 conj sacrificed,subjected
R1653 T2108 T2107 prep on,sacrificed
R1654 T2109 T2110 nummod 6,hours
R1655 T2110 T2108 pobj hours,on
R1656 T2111 T2110 punct ",",hours
R1657 T2112 T2113 nummod 1,day
R1658 T2113 T2110 npadvmod day,hours
R1659 T2114 T2110 punct ",",hours
R1660 T2115 T2116 nummod 3,days
R1661 T2116 T2110 appos days,hours
R1662 T2117 T2116 cc and,days
R1663 T2118 T2119 nummod 7,days
R1664 T2119 T2116 conj days,days
R1665 T2120 T2119 prep after,days
R1666 T2121 T2122 det the,injection
R1667 T2122 T2120 pobj injection,after
R1668 T2123 T2119 punct ",",days
R1669 T2124 T2116 advmod respectively,days
R1670 T2125 T2094 punct .,subjected
R1671 T2126 T2127 nummod Five,rats
R1672 T2127 T2136 nsubjpass rats,sacrificed
R1673 T2128 T2127 prep in,rats
R1674 T2129 T2130 det each,group
R1675 T2130 T2128 pobj group,in
R1676 T2131 T2127 prep at,rats
R1677 T2132 T2133 det each,time
R1678 T2133 T2131 pobj time,at
R1679 T2134 T2136 nsubjpass point,sacrificed
R1680 T2135 T2136 auxpass were,sacrificed
R1681 T2136 T2136 ROOT sacrificed,sacrificed
R1682 T2137 T2136 agent by,sacrificed
R1683 T2138 T2139 amod transcardially,perfusion
R1684 T2139 T2137 pobj perfusion,by
R1685 T2140 T2139 prep of,perfusion
R1686 T2141 T2142 amod normal,saline
R1687 T2142 T2140 pobj saline,of
R1688 T2143 T2136 advcl followed,sacrificed
R1689 T2144 T2143 agent by,followed
R1690 T2145 T2146 nummod 4,%
R1691 T2146 T2144 pobj %,by
R1692 T2147 T2136 conj buffered,sacrificed
R1693 T2148 T2149 compound Para,formaldehyde
R1694 T2149 T2147 dobj formaldehyde,buffered
R1695 T2150 T2153 punct (,7.4
R1696 T2151 T2153 quantmod pH,7.4
R1697 T2152 T2153 punct =,7.4
R1698 T2153 T2149 appos 7.4,formaldehyde
R1699 T2154 T2149 punct ),formaldehyde
R1700 T2155 T2136 punct .,sacrificed
R1701 T2156 T2157 det The,brains
R1702 T2157 T2159 nsubjpass brains,removed
R1703 T2158 T2159 auxpass were,removed
R1704 T2159 T2159 ROOT removed,removed
R1705 T2160 T2159 punct ",",removed
R1706 T2161 T2159 conj postfixed,removed
R1707 T2162 T2161 punct ",",postfixed
R1708 T2163 T2161 amod embedded,postfixed
R1709 T2164 T2163 prep in,embedded
R1710 T2165 T2164 pobj paraffin,in
R1711 T2166 T2161 punct ",",postfixed
R1712 T2167 T2161 cc and,postfixed
R1713 T2168 T2161 conj cut,postfixed
R1714 T2169 T2168 prep into,cut
R1715 T2170 T2169 pobj sections,into
R1716 T2171 T2170 punct (,sections
R1717 T2172 T2173 nummod 7,μm
R1718 T2173 T2170 appos μm,sections
R1719 T2174 T2170 punct ),sections
R1720 T2175 T2176 mark as,described
R1721 T2176 T2161 advcl described,postfixed
R1722 T2177 T2178 advmod previously,[
R1723 T2178 T2180 amod [,]
R1724 T2179 T2180 nummod 8,]
R1725 T2180 T2176 dobj ],described
R1726 T2181 T2159 punct .,removed
R1727 T2182 T2183 nummod Five,rats
R1728 T2183 T2192 nsubjpass rats,sacrificed
R1729 T2184 T2183 prep in,rats
R1730 T2185 T2186 det each,group
R1731 T2186 T2184 pobj group,in
R1732 T2187 T2183 prep at,rats
R1733 T2188 T2189 det each,time
R1734 T2189 T2190 compound time,point
R1735 T2190 T2187 pobj point,at
R1736 T2191 T2192 auxpass were,sacrificed
R1737 T2192 T2192 ROOT sacrificed,sacrificed
R1738 T2193 T2192 agent by,sacrificed
R1739 T2194 T2192 prep over,sacrificed
R1740 T2195 T2196 compound dose,injection
R1741 T2196 T2194 pobj injection,over
R1742 T2197 T2196 prep of,injection
R1743 T2198 T2197 pobj Ketamine,of
R1744 T2199 T2192 punct .,sacrificed
R1745 T2200 T2201 det The,brains
R1746 T2201 T2203 nsubjpass brains,removed
R1747 T2202 T2203 auxpass were,removed
R1748 T2203 T2203 ROOT removed,removed
R1749 T2204 T2203 cc and,removed
R1750 T2205 T2203 conj stored,removed
R1751 T2206 T2205 prep at,stored
R1752 T2207 T2210 det minus,C
R1753 T2208 T2209 nummod 80,°
R1754 T2209 T2210 nummod °,C
R1755 T2210 T2205 npadvmod C,stored
R1756 T2211 T2210 prep for,C
R1757 T2212 T2211 pobj RT-PCR,for
R1758 T2213 T2212 cc and,RT-PCR
R1759 T2214 T2215 compound Western,Blots
R1760 T2215 T2212 conj Blots,RT-PCR
R1761 T2216 T2203 punct .,removed
R1960 T2449 T2449 ROOT 2.2,2.2
R1961 T2450 T2449 punct .,2.2
R1962 T2451 T2476 npadvmod Induction,induced
R1963 T2452 T2451 prep of,Induction
R1964 T2453 T2454 compound Intracerebral,Hemorrhage
R1965 T2454 T2452 pobj Hemorrhage,of
R1966 T2455 T2459 mark Since,occur
R1967 T2456 T2458 amod most,hemorrhages
R1968 T2457 T2458 amod intracerebral,hemorrhages
R1969 T2458 T2459 nsubj hemorrhages,occur
R1970 T2459 T2476 advcl occur,induced
R1971 T2460 T2459 prep in,occur
R1972 T2461 T2463 det the,ganglia
R1973 T2462 T2463 amod basal,ganglia
R1974 T2463 T2460 pobj ganglia,in
R1975 T2464 T2459 advmod clinically,occur
R1976 T2465 T2476 punct ",",induced
R1977 T2466 T2476 prep in,induced
R1978 T2467 T2469 det the,study
R1979 T2468 T2469 amod present,study
R1980 T2469 T2466 pobj study,in
R1981 T2470 T2469 punct ",",study
R1982 T2471 T2472 compound rat,model
R1983 T2472 T2469 appos model,study
R1984 T2473 T2472 prep of,model
R1985 T2474 T2473 pobj ICH,of
R1986 T2475 T2476 auxpass was,induced
R1987 T2476 T2476 ROOT induced,induced
R1988 T2477 T2476 prep in,induced
R1989 T2478 T2480 amod left,ganglia
R1990 T2479 T2480 amod basal,ganglia
R1991 T2480 T2477 pobj ganglia,in
R1992 T2481 T2476 punct .,induced
R1993 T2482 T2483 nsubj Rats,were
R1994 T2483 T2483 ROOT were,were
R1995 T2484 T2483 acomp anesthetized,were
R1996 T2485 T2484 prep with,anesthetized
R1997 T2486 T2487 amod intra-peritoneal,sodium
R1998 T2487 T2485 pobj sodium,with
R1999 T2488 T2487 amod pentobarbital,sodium
R2000 T2489 T2491 punct (,mg/kg
R2001 T2490 T2491 nummod 60,mg/kg
R2002 T2491 T2488 appos mg/kg,pentobarbital
R2003 T2492 T2491 punct ),mg/kg
R2004 T2493 T2483 punct .,were
R2005 T2494 T2495 det The,body
R2006 T2495 T2501 nsubjpass body,maintained
R2007 T2496 T2495 punct (,body
R2008 T2497 T2495 appos rectal,body
R2009 T2498 T2495 punct ),body
R2010 T2499 T2501 nsubjpass temperature,maintained
R2011 T2500 T2501 auxpass was,maintained
R2012 T2501 T2501 ROOT maintained,maintained
R2013 T2502 T2501 prep at,maintained
R2014 T2503 T2504 nummod 37,°
R2015 T2504 T2505 nummod °,C
R2016 T2505 T2502 pobj C,at
R2017 T2506 T2501 prep during,maintained
R2018 T2507 T2508 det the,surgery
R2019 T2508 T2506 pobj surgery,during
R2020 T2509 T2501 advcl using,maintained
R2021 T2510 T2513 det a,system
R2022 T2511 T2513 amod feedback-controlled,system
R2023 T2512 T2513 compound heating,system
R2024 T2513 T2509 dobj system,using
R2025 T2514 T2501 punct .,maintained
R2026 T2515 T2516 det The,rats
R2027 T2516 T2518 nsubjpass rats,positioned
R2028 T2517 T2518 auxpass were,positioned
R2029 T2518 T2518 ROOT positioned,positioned
R2030 T2519 T2518 prep in,positioned
R2031 T2520 T2522 det a,frame
R2032 T2521 T2522 compound stereotactic,frame
R2033 T2522 T2519 pobj frame,in
R2034 T2523 T2518 punct ",",positioned
R2035 T2524 T2518 cc and,positioned
R2036 T2525 T2526 det the,scalp
R2037 T2526 T2528 nsubjpass scalp,incised
R2038 T2527 T2528 auxpass was,incised
R2039 T2528 T2518 conj incised,positioned
R2040 T2529 T2528 prep along,incised
R2041 T2530 T2531 det the,midline
R2042 T2531 T2529 pobj midline,along
R2043 T2532 T2528 punct .,incised
R2044 T2533 T2544 advcl Using,opened
R2045 T2534 T2536 det a,technique
R2046 T2535 T2536 amod sterile,technique
R2047 T2536 T2533 dobj technique,Using
R2048 T2537 T2544 punct ",",opened
R2049 T2538 T2542 det a,hole
R2050 T2539 T2540 nummod 1,mm
R2051 T2540 T2542 compound mm,hole
R2052 T2541 T2542 compound burr,hole
R2053 T2542 T2544 nsubjpass hole,opened
R2054 T2543 T2544 auxpass was,opened
R2055 T2544 T2544 ROOT opened,opened
R2056 T2545 T2544 prep in,opened
R2057 T2546 T2547 det the,skull
R2058 T2547 T2545 pobj skull,in
R2059 T2548 T2544 prep on,opened
R2060 T2549 T2552 det the,suture
R2061 T2550 T2552 amod left,suture
R2062 T2551 T2552 amod coronal,suture
R2063 T2552 T2548 pobj suture,on
R2064 T2553 T2554 nummod 3,mm
R2065 T2554 T2544 npadvmod mm,opened
R2066 T2555 T2554 amod lateral,mm
R2067 T2556 T2544 prep to,opened
R2068 T2557 T2558 det the,midline
R2069 T2558 T2556 pobj midline,to
R2070 T2559 T2544 punct .,opened
R2071 T2560 T2563 det A,needle
R2072 T2561 T2563 amod blunt,needle
R2073 T2562 T2563 amod 26-gauge,needle
R2074 T2563 T2565 nsubjpass needle,inserted
R2075 T2564 T2565 auxpass was,inserted
R2076 T2565 T2565 ROOT inserted,inserted
R2077 T2566 T2565 prep into,inserted
R2078 T2567 T2570 det the,ganglia
R2079 T2568 T2570 amod left,ganglia
R2080 T2569 T2570 amod basal,ganglia
R2081 T2570 T2566 pobj ganglia,into
R2082 T2571 T2570 prep under,ganglia
R2083 T2572 T2573 amod stereotactic,guidance
R2084 T2573 T2571 pobj guidance,under
R2085 T2574 T2575 punct (,coordinates
R2086 T2575 T2565 parataxis coordinates,inserted
R2087 T2576 T2575 punct :,coordinates
R2088 T2577 T2578 nummod 0.2,mm
R2089 T2578 T2579 compound mm,anterior
R2090 T2579 T2575 dobj anterior,coordinates
R2091 T2580 T2579 punct ",",anterior
R2092 T2581 T2582 nummod 6.0,mm
R2093 T2582 T2583 compound mm,ventral
R2094 T2583 T2579 conj ventral,anterior
R2095 T2584 T2583 punct ",",ventral
R2096 T2585 T2583 cc and,ventral
R2097 T2586 T2587 nummod 3.0,mm
R2098 T2587 T2583 conj mm,ventral
R2099 T2588 T2587 amod lateral,mm
R2100 T2589 T2575 prep to,coordinates
R2101 T2590 T2591 det the,midline
R2102 T2591 T2589 pobj midline,to
R2103 T2592 T2575 punct ),coordinates
R2104 T2593 T2565 punct .,inserted
R2105 T2594 T2604 advmod Then,infused
R2106 T2595 T2604 punct ",",infused
R2107 T2596 T2598 det a,μL
R2108 T2597 T2598 nummod 75,μL
R2109 T2598 T2604 nsubjpass μL,infused
R2110 T2599 T2598 prep of,μL
R2111 T2600 T2602 amod autologous,blood
R2112 T2601 T2602 amod whole,blood
R2113 T2602 T2599 pobj blood,of
R2114 T2603 T2604 auxpass was,infused
R2115 T2604 T2604 ROOT infused,infused
R2116 T2605 T2604 prep at,infused
R2117 T2606 T2607 det a,rate
R2118 T2607 T2605 pobj rate,at
R2119 T2608 T2607 prep of,rate
R2120 T2609 T2612 nummod 20,min
R2121 T2610 T2612 compound μL,min
R2122 T2611 T2612 compound /,min
R2123 T2612 T2608 pobj min,of
R2124 T2613 T2604 prep with,infused
R2125 T2614 T2615 det the,use
R2126 T2615 T2613 pobj use,with
R2127 T2616 T2615 prep of,use
R2128 T2617 T2619 det a,pump
R2129 T2618 T2619 amod microinfusion,pump
R2130 T2619 T2616 pobj pump,of
R2131 T2620 T2604 punct .,infused
R2132 T2621 T2631 prep After,withdrawn
R2133 T2622 T2623 det the,completion
R2134 T2623 T2621 pobj completion,After
R2135 T2624 T2623 prep of,completion
R2136 T2625 T2626 det the,infusion
R2137 T2626 T2624 pobj infusion,of
R2138 T2627 T2631 punct ",",withdrawn
R2139 T2628 T2629 det the,needle
R2140 T2629 T2631 nsubjpass needle,withdrawn
R2141 T2630 T2631 auxpass was,withdrawn
R2142 T2631 T2631 ROOT withdrawn,withdrawn
R2143 T2632 T2631 advmod quickly,withdrawn
R2144 T2633 T2631 punct ",",withdrawn
R2145 T2634 T2635 compound cyanoacrylate,glue
R2146 T2635 T2637 nsubjpass glue,placed
R2147 T2636 T2637 auxpass was,placed
R2148 T2637 T2631 conj placed,withdrawn
R2149 T2638 T2637 prep around,placed
R2150 T2639 T2641 det the,hole
R2151 T2640 T2641 compound burr,hole
R2152 T2641 T2638 pobj hole,around
R2153 T2642 T2637 punct ",",placed
R2154 T2643 T2637 cc and,placed
R2155 T2644 T2646 det the,incision
R2156 T2645 T2646 compound skin,incision
R2157 T2646 T2647 nsubj incision,was
R2158 T2647 T2637 conj was,placed
R2159 T2648 T2647 acomp closed,was
R2160 T2649 T2648 prep with,closed
R2161 T2650 T2649 pobj sutures,with
R2162 T2651 T2647 punct .,was
R2163 T2652 T2665 prep For,injected
R2164 T2653 T2657 det the,rats
R2165 T2654 T2657 amod normal,rats
R2166 T2655 T2656 amod saline,control
R2167 T2656 T2657 compound control,rats
R2168 T2657 T2652 pobj rats,For
R2169 T2658 T2665 punct ",",injected
R2170 T2659 T2660 advmod only,75
R2172 T2661 T2663 nmod μL,saline
R2173 T2662 T2663 amod normal,saline
R2174 T2663 T2665 nsubjpass saline,injected
R2175 T2664 T2665 auxpass was,injected
R2176 T2665 T2665 ROOT injected,injected
R2177 T2666 T2665 punct .,injected
R2436 T3069 T3069 ROOT 2.3,2.3
R2437 T3070 T3069 punct .,2.3
R2438 T3071 T3086 advcl Detection,isolated
R2439 T3072 T3071 prep of,Detection
R2440 T3073 T3074 compound TLR4,mRNA
R2441 T3074 T3072 pobj mRNA,of
R2442 T3075 T3071 prep by,Detection
R2443 T3076 T3077 det the,Method
R2444 T3077 T3075 pobj Method,by
R2445 T3078 T3077 prep of,Method
R2446 T3079 T3080 compound RT-PCR,Briefly
R2447 T3080 T3078 pobj Briefly,of
R2448 T3081 T3086 punct ",",isolated
R2449 T3082 T3084 amod total,samples
R2450 T3083 T3084 compound RNA,samples
R2451 T3084 T3086 nsubjpass samples,isolated
R2452 T3085 T3086 auxpass were,isolated
R2453 T3086 T3086 ROOT isolated,isolated
R2454 T3087 T3086 prep from,isolated
R2455 T3088 T3089 amod peri-hemorrhage,regions
R2456 T3089 T3087 pobj regions,from
R2457 T3090 T3087 prep in,from
R2458 T3091 T3093 amod left,ganglia
R2459 T3092 T3093 amod basal,ganglia
R2460 T3093 T3090 pobj ganglia,in
R2461 T3094 T3086 advcl using,isolated
R2462 T3095 T3100 advmod Simply,Kit
R2463 T3096 T3100 nmod P,Kit
R2464 T3097 T3100 compound Total,Kit
R2465 T3098 T3099 compound RNA,isolation
R2466 T3099 T3100 compound isolation,Kit
R2467 T3100 T3094 dobj Kit,using
R2468 T3101 T3102 punct (,BioFlux
R2469 T3102 T3100 appos BioFlux,Kit
R2470 T3103 T3102 punct ",",BioFlux
R2471 T3104 T3102 conj HZ,BioFlux
R2472 T3105 T3104 punct ",",HZ
R2473 T3106 T3104 npadvmod China,HZ
R2474 T3107 T3104 punct ),HZ
R2475 T3108 T3086 prep according,isolated
R2476 T3109 T3108 prep to,according
R2477 T3110 T3111 det the,manufacturer
R2478 T3111 T3113 poss manufacturer,instructions
R2479 T3112 T3111 case 's,manufacturer
R2480 T3113 T3109 pobj instructions,to
R2481 T3114 T3086 punct .,isolated
R2482 T3115 T3116 det The,quantity
R2483 T3116 T3121 nsubjpass quantity,determined
R2484 T3117 T3116 prep of,quantity
R2485 T3118 T3119 amod total,RNA
R2486 T3119 T3117 pobj RNA,of
R2487 T3120 T3121 auxpass was,determined
R2488 T3121 T3121 ROOT determined,determined
R2489 T3122 T3121 prep on,determined
R2490 T3123 T3124 det a,Nanodrop
R2491 T3124 T3122 pobj Nanodrop,on
R2492 T3125 T3124 punct (,Nanodrop
R2493 T3126 T3127 compound ND-1000,Spectrophotometer
R2494 T3127 T3124 appos Spectrophotometer,Nanodrop
R2495 T3128 T3124 punct ),Nanodrop
R2496 T3129 T3121 prep by,determined
R2497 T3130 T3129 pcomp measuring,by
R2498 T3131 T3132 amod optical,density
R2499 T3132 T3130 dobj density,measuring
R2500 T3133 T3130 prep at,measuring
R2501 T3134 T3133 pobj A260,at
R2502 T3135 T3134 cc and,A260
R2503 T3136 T3134 conj A280,A260
R2504 T3137 T3138 compound nm,wavelength
R2505 T3138 T3130 npadvmod wavelength,measuring
R2506 T3139 T3121 punct .,determined
R2507 T3140 T3147 advmod Then,adjusted
R2508 T3141 T3147 punct ",",adjusted
R2509 T3142 T3143 det the,concentrations
R2510 T3143 T3147 nsubjpass concentrations,adjusted
R2511 T3144 T3143 prep of,concentrations
R2512 T3145 T3144 pobj mRNA,of
R2513 T3146 T3147 auxpass were,adjusted
R2514 T3147 T3147 ROOT adjusted,adjusted
R2515 T3148 T3147 prep to,adjusted
R2516 T3149 T3150 nummod 1.0,g/mL
R2517 T3150 T3148 pobj g/mL,to
R2518 T3151 T3147 punct .,adjusted
R2519 T3152 T3154 nsubjpass RNA,reverse-transcribed
R2520 T3153 T3154 auxpass was,reverse-transcribed
R2521 T3154 T3154 ROOT reverse-transcribed,reverse-transcribed
R2522 T3155 T3154 prep into,reverse-transcribed
R2523 T3156 T3155 pobj cDNA,into
R2524 T3157 T3154 prep in,reverse-transcribed
R2525 T3158 T3161 nummod 20,system
R2526 T3159 T3161 compound μL,system
R2527 T3160 T3161 compound reaction,system
R2528 T3161 T3157 pobj system,in
R2529 T3162 T3154 advcl using,reverse-transcribed
R2530 T3163 T3166 compound Superscript,Kit
R2531 T3164 T3166 compound First-Strand,Kit
R2532 T3165 T3166 compound Synthesis,Kit
R2533 T3166 T3162 dobj Kit,using
R2534 T3167 T3162 prep for,using
R2535 T3168 T3167 pobj RT-PCR,for
R2536 T3169 T3171 punct (,Inc
R2537 T3170 T3171 compound promega,Inc
R2538 T3171 T3168 appos Inc,RT-PCR
R2539 T3172 T3168 punct ),RT-PCR
R2540 T3173 T3162 prep under,using
R2541 T3174 T3173 pobj conditions,under
R2542 T3175 T3174 acl described,conditions
R2543 T3176 T3175 agent by,described
R2544 T3177 T3178 det the,supplier
R2545 T3178 T3176 pobj supplier,by
R2546 T3179 T3154 punct .,reverse-transcribed
R2547 T3180 T3181 nummod One,microliter
R2548 T3181 T3185 nsubjpass microliter,used
R2549 T3182 T3181 prep of,microliter
R2550 T3183 T3182 pobj cDNA,of
R2551 T3184 T3185 auxpass was,used
R2552 T3185 T3185 ROOT used,used
R2553 T3186 T3187 aux to,amplify
R2554 T3187 T3185 xcomp amplify,used
R2555 T3188 T3191 det the,fragment
R2556 T3189 T3191 nummod TLR4,fragment
R2557 T3190 T3191 compound gene,fragment
R2558 T3191 T3187 dobj fragment,amplify
R2559 T3192 T3187 prep with,amplify
R2560 T3193 T3196 nummod 1,buffer
R2561 T3194 T3196 nummod ×,buffer
R2562 T3195 T3196 compound PCR,buffer
R2563 T3196 T3192 pobj buffer,with
R2564 T3197 T3196 punct ",",buffer
R2565 T3198 T3200 nummod 1.5,MgCl2
R2566 T3199 T3200 compound mM,MgCl2
R2567 T3200 T3196 appos MgCl2,buffer
R2568 T3201 T3200 punct ",",MgCl2
R2569 T3202 T3203 nummod 200,μM
R2570 T3203 T3200 appos μM,MgCl2
R2571 T3204 T3203 prep of,μM
R2572 T3205 T3206 det each,dNTP
R2573 T3206 T3204 pobj dNTP,of
R2574 T3207 T3203 punct ",",μM
R2575 T3208 T3209 nummod 200,μM
R2576 T3209 T3203 conj μM,μM
R2577 T3210 T3209 prep of,μM
R2578 T3211 T3210 pobj primers,of
R2579 T3212 T3209 punct ",",μM
R2580 T3213 T3209 cc and,μM
R2581 T3214 T3217 nummod 2u,polymerase
R2582 T3215 T3217 compound Taq,polymerase
R2583 T3216 T3217 compound DNA,polymerase
R2584 T3217 T3209 conj polymerase,μM
R2585 T3218 T3185 punct .,used
R2586 T3219 T3220 det The,house
R2587 T3220 T3222 compound house,gene
R2588 T3221 T3222 compound keep,gene
R2589 T3222 T3227 nsubjpass gene,used
R2590 T3223 T3222 punct (,gene
R2591 T3224 T3222 appos β-actin,gene
R2592 T3225 T3222 punct ),gene
R2593 T3226 T3227 auxpass was,used
R2594 T3227 T3227 ROOT used,used
R2595 T3228 T3227 prep as,used
R2596 T3229 T3231 det an,control
R2597 T3230 T3231 amod internal,control
R2598 T3231 T3228 pobj control,as
R2599 T3232 T3227 punct .,used
R2600 T3233 T3236 det The,sequences
R2601 T3234 T3235 compound PCR,primer
R2602 T3235 T3236 compound primer,sequences
R2603 T3236 T3238 nsubjpass sequences,designed
R2604 T3237 T3238 auxpass were,designed
R2605 T3238 T3238 ROOT designed,designed
R2606 T3239 T3238 prep according,designed
R2607 T3240 T3239 prep to,according
R2608 T3241 T3246 det the,sequences
R2609 T3242 T3246 nummod TLR4,sequences
R2610 T3243 T3242 cc and,TLR4
R2611 T3244 T3242 conj β-actin,TLR4
R2612 T3245 T3246 compound gene,sequences
R2613 T3246 T3240 pobj sequences,to
R2614 T3247 T3246 acl reported,sequences
R2615 T3248 T3247 prep in,reported
R2616 T3249 T3248 pobj GenBank,in
R2617 T3250 T3238 punct .,designed
R2618 T3251 T3251 ROOT TLR4,TLR4
R2619 T3252 T3254 punct (,bp
R2620 T3253 T3254 nummod 145,bp
R2621 T3254 T3251 appos bp,TLR4
R2622 T3255 T3254 punct ),bp
R2623 T3256 T3254 punct :,bp
R2624 T3257 T3263 advmod forward,′
R2625 T3258 T3259 punct :,5
R2626 T3259 T3263 nummod 5,′
R2627 T3260 T3259 punct ′,5
R2628 T3261 T3262 punct -,AGCTTTGGTCAGTTGGCTCT-3
R2629 T3262 T3263 compound AGCTTTGGTCAGTTGGCTCT-3,′
R2630 T3263 T3254 appos ′,bp
R2631 T3264 T3254 punct ;,bp
R2632 T3265 T3287 ccomp reverse,reverse
R2633 T3266 T3265 punct :,reverse
R2634 T3267 T3271 nummod 5,′
R2635 T3268 T3270 punct ′,CAGGATGACACCATTGAAGC-3
R2636 T3269 T3270 punct -,CAGGATGACACCATTGAAGC-3
R2637 T3270 T3271 compound CAGGATGACACCATTGAAGC-3,′
R2638 T3271 T3265 appos ′,reverse
R2639 T3272 T3287 punct ;,reverse
R2640 T3273 T3287 ccomp β-actin,reverse
R2641 T3274 T3276 punct (,bp
R2642 T3275 T3276 nummod 701,bp
R2643 T3276 T3273 appos bp,β-actin
R2644 T3277 T3273 punct ),β-actin
R2645 T3278 T3273 punct :,β-actin
R2646 T3279 T3273 advmod forward,β-actin
R2647 T3280 T3273 punct :,β-actin
R2648 T3281 T3284 meta 5,GCCAACCGTGAAAAAGATG-3
R2649 T3282 T3281 punct ′,5
R2650 T3283 T3284 punct -,GCCAACCGTGAAAAAGATG-3
R2651 T3284 T3285 compound GCCAACCGTGAAAAAGATG-3,′
R2652 T3285 T3273 appos ′,β-actin
R2653 T3286 T3287 punct ;,reverse
R2654 T3287 T3251 appos reverse,TLR4
R2655 T3288 T3287 punct :,reverse
R2656 T3289 T3292 nummod 5,CCAGGATAGAGCCACCAAT-3
R2657 T3290 T3292 punct ′,CCAGGATAGAGCCACCAAT-3
R2658 T3291 T3292 punct -,CCAGGATAGAGCCACCAAT-3
R2659 T3292 T3293 compound CCAGGATAGAGCCACCAAT-3,′
R2660 T3293 T3287 appos ′,reverse
R2661 T3294 T3287 punct .,reverse
R2662 T3295 T3296 compound Reaction,cycles
R2663 T3296 T3298 nsubjpass cycles,performed
R2664 T3297 T3298 auxpass were,performed
R2665 T3298 T3298 ROOT performed,performed
R2666 T3299 T3298 prep at,performed
R2667 T3300 T3302 det the,condition
R2668 T3301 T3302 amod following,condition
R2669 T3302 T3299 pobj condition,at
R2670 T3303 T3298 punct :,performed
R2671 T3304 T3314 nummod 94,s
R2672 T3305 T3306 compound °,C
R2673 T3306 T3312 nmod C,C
R2674 T3307 T3306 nummod 2,C
R2675 T3308 T3312 nmod min,C
R2676 T3309 T3308 punct ",",min
R2677 T3310 T3311 nummod 94,°
R2678 T3311 T3312 compound °,C
R2679 T3312 T3314 nmod C,s
R2680 T3313 T3312 nummod 40,C
R2681 T3314 T3298 dep s,performed
R2682 T3315 T3314 punct ",",s
R2683 T3316 T3327 nummod 55,s
R2684 T3317 T3318 compound °,C
R2685 T3318 T3327 nmod C,s
R2686 T3319 T3318 nummod 40,C
R2687 T3320 T3318 prep s,C
R2688 T3321 T3318 punct ",",C
R2689 T3322 T3318 cc and,C
R2690 T3323 T3318 conj 72,C
R2691 T3324 T3325 compound °,C
R2692 T3325 T3327 nmod C,s
R2693 T3326 T3325 nummod 60,C
R2694 T3327 T3314 appos s,s
R2695 T3328 T3298 punct .,performed
R2696 T3329 T3330 det The,reaction
R2697 T3330 T3332 nsubjpass reaction,stopped
R2698 T3331 T3332 auxpass was,stopped
R2699 T3332 T3332 ROOT stopped,stopped
R2700 T3333 T3332 prep after,stopped
R2701 T3334 T3335 nummod 31,cycles
R2702 T3335 T3333 pobj cycles,after
R2703 T3336 T3332 punct .,stopped
R2704 T3337 T3338 compound PCR,products
R2705 T3338 T3340 nsubjpass products,electrophoresed
R2706 T3339 T3340 auxpass were,electrophoresed
R2707 T3340 T3340 ROOT electrophoresed,electrophoresed
R2708 T3341 T3340 prep through,electrophoresed
R2709 T3342 T3343 amod agarose,gel
R2710 T3343 T3341 pobj gel,through
R2711 T3344 T3340 punct .,electrophoresed
R2712 T3345 T3346 compound Image,Acquisition
R2713 T3346 T3351 nsubjpass Acquisition,used
R2714 T3347 T3346 cc and,Acquisition
R2715 T3348 T3346 conj Analysis,Acquisition
R2716 T3349 T3346 conj software,Acquisition
R2717 T3350 T3351 auxpass were,used
R2718 T3351 T3351 ROOT used,used
R2719 T3352 T3353 aux to,determine
R2720 T3353 T3351 xcomp determine,used
R2721 T3354 T3355 compound band,densities
R2722 T3355 T3353 dobj densities,determine
R2723 T3356 T3351 punct .,used
R2724 T3357 T3358 det The,abundance
R2725 T3358 T3363 nsubjpass abundance,expressed
R2726 T3359 T3358 prep of,abundance
R2727 T3360 T3361 nummod TLR4,mRNA
R2728 T3361 T3359 pobj mRNA,of
R2729 T3362 T3363 auxpass was,expressed
R2730 T3363 T3363 ROOT expressed,expressed
R2731 T3364 T3363 prep as,expressed
R2732 T3365 T3366 det the,ratio
R2733 T3366 T3364 pobj ratio,as
R2734 T3367 T3366 prep of,ratio
R2735 T3368 T3369 nummod TLR4,mRNA
R2736 T3369 T3367 pobj mRNA,of
R2737 T3370 T3371 aux to,β-actin
R2738 T3371 T3366 relcl β-actin,ratio
R2739 T3372 T3371 dobj mRNA,β-actin
R2740 T3373 T3363 punct .,expressed
R2815 T3606 T3606 ROOT 2.4,2.4
R2816 T3607 T3606 punct .,2.4
R2817 T3608 T3608 ROOT Immunohistochemistry,Immunohistochemistry
R2818 T3609 T3610 punct (,IHC
R2819 T3610 T3608 appos IHC,Immunohistochemistry
R2820 T3611 T3608 punct ),Immunohistochemistry
R2821 T3612 T3613 det The,IHC
R2822 T3613 T3618 nsubjpass IHC,performed
R2823 T3614 T3613 acl staining,IHC
R2824 T3615 T3614 prep for,staining
R2825 T3616 T3615 pobj TLR4,for
R2826 T3617 T3618 auxpass was,performed
R2827 T3618 T3618 ROOT performed,performed
R2828 T3619 T3620 mark as,described
R2829 T3620 T3618 advcl described,performed
R2830 T3621 T3622 advmod previously,[
R2831 T3622 T3624 amod [,]
R2832 T3623 T3624 nummod 8,]
R2833 T3624 T3620 dobj ],described
R2834 T3625 T3618 punct .,performed
R2835 T3626 T3628 det The,antibody
R2836 T3627 T3628 amod primary,antibody
R2837 T3628 T3630 nsubj antibody,was
R2838 T3629 T3628 acl employed,antibody
R2839 T3630 T3630 ROOT was,was
R2840 T3631 T3632 compound rabbit,anti-TLR4
R2841 T3632 T3630 attr anti-TLR4,was
R2842 T3633 T3636 punct (,BA1717
R2843 T3634 T3636 amod WuHan,BA1717
R2844 T3635 T3636 punct ",",BA1717
R2845 T3636 T3632 appos BA1717,anti-TLR4
R2846 T3637 T3636 punct ),BA1717
R2847 T3638 T3630 punct .,was
R2848 T3639 T3642 det The,antibody
R2849 T3640 T3642 amod biotinylated,antibody
R2850 T3641 T3642 amod secondary,antibody
R2851 T3642 T3653 nsubjpass antibody,obtained
R2852 T3643 T3642 cc and,antibody
R2853 T3644 T3645 amod antibody-biotin-avidin-peroxidase,complexes
R2854 T3645 T3642 conj complexes,antibody
R2855 T3646 T3648 punct (,reagent
R2856 T3647 T3648 compound ABC,reagent
R2857 T3648 T3645 appos reagent,complexes
R2858 T3649 T3648 punct ",",reagent
R2859 T3650 T3648 appos SC-2018,reagent
R2860 T3651 T3648 punct ),reagent
R2861 T3652 T3653 auxpass were,obtained
R2862 T3653 T3653 ROOT obtained,obtained
R2863 T3654 T3653 prep from,obtained
R2864 T3655 T3658 compound Santa,Inc.
R2865 T3656 T3658 compound Cruz,Inc.
R2866 T3657 T3658 compound Biotechnology,Inc.
R2867 T3658 T3654 pobj Inc.,from
R2868 T3659 T3658 punct (,Inc.
R2869 T3660 T3661 compound Santa,Cruz
R2870 T3661 T3658 npadvmod Cruz,Inc.
R2871 T3662 T3661 punct ",",Cruz
R2872 T3663 T3661 appos CA,Cruz
R2873 T3664 T3658 punct ),Inc.
R2874 T3665 T3653 punct .,obtained
R2875 T3666 T3667 nsubj Slides,processed
R2876 T3667 T3671 csubj processed,served
R2877 T3668 T3667 prep without,processed
R2878 T3669 T3670 amod primary,antibodies
R2879 T3670 T3668 pobj antibodies,without
R2880 T3671 T3671 ROOT served,served
R2881 T3672 T3671 prep as,served
R2882 T3673 T3674 amod negative,controls
R2883 T3674 T3672 pobj controls,as
R2884 T3675 T3671 punct .,served
R2994 T3848 T3848 ROOT 2.5,2.5
R2995 T3849 T3848 punct .,2.5
R2996 T3850 T3853 amod Western,proteins
R2997 T3851 T3853 compound Blots,proteins
R2998 T3852 T3853 compound Cellular,proteins
R2999 T3853 T3855 nsubjpass proteins,prepared
R3000 T3854 T3855 auxpass were,prepared
R3001 T3855 T3855 ROOT prepared,prepared
R3002 T3856 T3855 prep from,prepared
R3003 T3857 T3859 amod ICH,hemispheres
R3004 T3858 T3859 amod cerebral,hemispheres
R3005 T3859 T3856 pobj hemispheres,from
R3006 T3860 T3859 punct ",",hemispheres
R3007 T3861 T3859 acl electrophoresed,hemispheres
R3008 T3862 T3861 prep with,electrophoresed
R3009 T3863 T3864 amod SDS-polyacrylamide,gel
R3010 T3864 T3862 pobj gel,with
R3011 T3865 T3861 cc and,electrophoresed
R3012 T3866 T3861 conj transferred,electrophoresed
R3013 T3867 T3866 prep onto,transferred
R3014 T3868 T3869 compound Hybond,ECL
R3015 T3869 T3870 compound ECL,membranes
R3016 T3870 T3867 pobj membranes,onto
R3017 T3871 T3873 punct (,Pharmacia
R3018 T3872 T3873 compound Amersham,Pharmacia
R3019 T3873 T3870 appos Pharmacia,membranes
R3020 T3874 T3873 punct ",",Pharmacia
R3021 T3875 T3873 conj Piscataway,Pharmacia
R3022 T3876 T3875 punct ",",Piscataway
R3023 T3877 T3875 conj NJ,Piscataway
R3024 T3878 T3870 punct ),membranes
R3025 T3879 T3855 punct .,prepared
R3026 T3880 T3882 det The,membranes
R3027 T3881 T3882 compound ECL,membranes
R3028 T3882 T3884 nsubjpass membranes,incubated
R3029 T3883 T3884 auxpass were,incubated
R3030 T3884 T3884 ROOT incubated,incubated
R3031 T3885 T3884 prep with,incubated
R3032 T3886 T3889 det the,antibody
R3033 T3887 T3889 amod appropriate,antibody
R3034 T3888 T3889 amod primary,antibody
R3035 T3889 T3885 pobj antibody,with
R3036 T3890 T3889 punct (,antibody
R3037 T3891 T3889 appos WuHan,antibody
R3038 T3892 T3889 punct ",",antibody
R3039 T3893 T3889 appos BA1717,antibody
R3040 T3894 T3884 punct ),incubated
R3041 T3895 T3884 advcl followed,incubated
R3042 T3896 T3895 agent by,followed
R3043 T3897 T3896 pobj incubation,by
R3044 T3898 T3895 prep with,followed
R3045 T3899 T3901 amod peroxidase-conjugated,antibodies
R3066 T3920 T3916 punct ),system
R3067 T3921 T3912 punct .,detected
R3068 T3922 T3924 det The,membranes
R3069 T3923 T3924 amod same,membranes
R3070 T3924 T3926 nsubjpass membranes,probed
R3071 T3925 T3926 auxpass were,probed
R3072 T3926 T3926 ROOT probed,probed
R3073 T3927 T3926 prep with,probed
R3074 T3928 T3927 pobj anti-GAPDH,with
R3075 T3929 T3928 punct (,anti-GAPDH
R3076 T3930 T3931 amod glyceraldehyde-3-phosphate,dehydrogenase
R3077 T3931 T3928 appos dehydrogenase,anti-GAPDH
R3078 T3932 T3931 punct ",",dehydrogenase
R3079 T3933 T3931 conj Biodesign,dehydrogenase
R3080 T3934 T3933 punct ",",Biodesign
R3081 T3935 T3933 appos Saco,Biodesign
R3082 T3936 T3935 punct ",",Saco
R3083 T3937 T3935 npadvmod Maine,Saco
R3084 T3938 T3935 punct ),Saco
R3085 T3939 T3926 prep after,probed
R3086 T3940 T3941 auxpass being,washed
R3087 T3941 T3939 pcomp washed,after
R3088 T3942 T3941 prep with,washed
R3089 T3943 T3942 pcomp stripping,with
R3090 T3944 T3943 dobj buffer,stripping
R3091 T3945 T3926 punct .,probed
R3092 T3946 T3947 det The,signals
R3093 T3947 T3949 nsubjpass signals,quantified
R3094 T3948 T3949 auxpass were,quantified
R3095 T3949 T3949 ROOT quantified,quantified
R3096 T3950 T3949 prep by,quantified
R3097 T3951 T3950 pcomp scanning,by
R3098 T3952 T3951 dobj densitometry,scanning
R3099 T3953 T3952 cc and,densitometry
R3100 T3954 T3956 amod computer-assisted,analysis
R3101 T3955 T3956 compound image,analysis
R3102 T3956 T3952 conj analysis,densitometry
R3103 T3957 T3949 punct .,quantified
R3278 T4204 T4206 punct (,extract
R3279 T4205 T4206 nsubj cytoplasmic,extract
R3280 T4206 T4206 ROOT extract,extract
R3281 T4207 T4206 punct ),extract
R3282 T4208 T4212 punct ",",resuspended
R3283 T4209 T4210 det the,pellets
R3284 T4210 T4212 nsubjpass pellets,resuspended
R3285 T4211 T4212 auxpass were,resuspended
R3286 T4212 T4212 ROOT resuspended,resuspended
R3287 T4213 T4212 prep in,resuspended
R3288 T4214 T4215 amod nuclear,extraction
R3289 T4215 T4213 pobj extraction,in
R3290 T4216 T4212 conj reagent,resuspended
R3291 T4217 T4212 punct .,resuspended
R3292 T4218 T4219 det The,tubes
R3293 T4219 T4223 nsubjpass tubes,put
R3294 T4220 T4219 acl containing,tubes
R3295 T4221 T4220 dobj pellets,containing
R3296 T4222 T4223 auxpass were,put
R3297 T4223 T4223 ROOT put,put
R3298 T4224 T4223 prep on,put
R3299 T4225 T4224 pobj vortex,on
R3300 T4226 T4223 prep for,put
R3301 T4227 T4228 nummod 15,seconds
R3302 T4228 T4226 pobj seconds,for
R3303 T4229 T4231 det every,minutes
R3304 T4230 T4231 nummod 10,minutes
R3305 T4231 T4223 npadvmod minutes,put
R3306 T4232 T4231 punct ",",minutes
R3307 T4233 T4231 prep for,minutes
R3308 T4234 T4235 det a,total
R3309 T4235 T4233 pobj total,for
R3310 T4236 T4235 prep of,total
R3311 T4237 T4238 nummod 40,minutes
R3312 T4238 T4236 pobj minutes,of
R3313 T4239 T4223 punct .,put
R3314 T4240 T4241 det The,tubes
R3315 T4241 T4243 nsubjpass tubes,centrifuged
R3316 T4242 T4243 auxpass were,centrifuged
R3317 T4243 T4243 ROOT centrifuged,centrifuged
R3318 T4244 T4243 prep at,centrifuged
R3319 T4245 T4246 amod maximum,speed
R3320 T4246 T4244 pobj speed,at
R3321 T4247 T4251 punct (,g
R3322 T4248 T4251 nmod ~,g
R3323 T4249 T4251 dep "16,000",g
R3324 T4250 T4251 nummod ×,g
R3325 T4251 T4246 appos g,speed
R3326 T4252 T4251 punct ),g
R3327 T4253 T4243 prep in,centrifuged
R3328 T4254 T4256 det a,centrifuge
R3329 T4255 T4256 amod micro,centrifuge
R3330 T4256 T4253 pobj centrifuge,in
R3331 T4257 T4243 prep for,centrifuged
R3332 T4258 T4259 nummod 10,minutes
R3333 T4259 T4257 pobj minutes,for
R3334 T4260 T4243 punct .,centrifuged
R3335 T4261 T4262 det The,supernatants
R3336 T4262 T4268 nsubjpass supernatants,transferred
R3337 T4263 T4262 punct (,supernatants
R3338 T4264 T4265 amod nuclear,extract
R3339 T4265 T4262 appos extract,supernatants
R3340 T4266 T4262 punct ),supernatants
R3341 T4267 T4268 auxpass were,transferred
R3342 T4268 T4268 ROOT transferred,transferred
R3343 T4269 T4268 prep to,transferred
R3344 T4270 T4273 det a,tube
R3345 T4271 T4273 amod clean,tube
R3346 T4272 T4273 amod prechilled,tube
R3347 T4273 T4269 pobj tube,to
R3348 T4274 T4268 cc and,transferred
R3349 T4275 T4268 conj stored,transferred
R3350 T4276 T4275 prep at,stored
R3351 T4277 T4279 nummod −,°
R3352 T4278 T4279 nummod 80,°
R3353 T4279 T4276 pobj °,at
R3354 T4280 T4275 npadvmod C,stored
R3355 T4281 T4275 prep until,stored
R3356 T4282 T4281 pobj use,until
R3357 T4283 T4268 punct .,transferred
R3358 T4284 T4286 nsubjpass EMSA,performed
R3359 T4285 T4286 auxpass was,performed
R3360 T4286 T4286 ROOT performed,performed
R3361 T4287 T4288 mark as,described
R3362 T4288 T4286 advcl described,performed
R3363 T4289 T4290 advmod previously,[
R3364 T4290 T4292 amod [,]
R3365 T4291 T4292 nummod 8,]
R3366 T4292 T4288 dobj ],described
R3367 T4293 T4286 punct .,performed
R3368 T4294 T4296 amod NFκB,activity
R3369 T4295 T4296 amod binding,activity
R3370 T4296 T4298 nsubjpass activity,examined
R3371 T4297 T4298 auxpass was,examined
R3372 T4298 T4298 ROOT examined,examined
R3373 T4299 T4298 prep in,examined
R3374 T4300 T4305 det a,mixture
R3375 T4301 T4302 nummod 15,μL
R3376 T4302 T4305 compound μL,mixture
R3377 T4303 T4304 amod binding,reaction
R3378 T4304 T4305 compound reaction,mixture
R3379 T4305 T4299 pobj mixture,in
R3380 T4306 T4305 acl containing,mixture
R3381 T4307 T4308 nummod 15,μg
R3382 T4308 T4317 nmod μg,]
R3383 T4309 T4308 prep of,μg
R3384 T4310 T4311 amod nuclear,proteins
R3385 T4311 T4309 pobj proteins,of
R3386 T4312 T4311 cc and,proteins
R3387 T4313 T4314 nummod 35,fmol
R3388 T4314 T4317 compound fmol,]
R3389 T4315 T4317 compound [,]
R3390 T4316 T4317 compound γ-32P,]
R3391 T4317 T4306 dobj ],containing
R3392 T4318 T4298 conj labeled,examined
R3393 T4319 T4322 amod double-stranded,oligonucleotide
R3394 T4320 T4321 compound NFκB,consensus
R3395 T4321 T4322 compound consensus,oligonucleotide
R3396 T4322 T4318 oprd oligonucleotide,labeled
R3397 T4323 T4298 punct .,examined
R3398 T4324 T4327 det A,assay
R3399 T4325 T4326 amod super,shift
R3400 T4326 T4327 compound shift,assay
R3401 T4327 T4335 nsubjpass assay,performed
R3402 T4328 T4327 acl using,assay
R3403 T4329 T4328 dobj antibodies,using
R3404 T4330 T4328 prep to,using
R3405 T4331 T4330 pobj P65,to
R3406 T4332 T4331 cc and,P65
R3407 T4333 T4331 conj P50,P65
R3408 T4334 T4335 auxpass was,performed
R3409 T4335 T4335 ROOT performed,performed
R3410 T4336 T4337 aux to,confirm
R3411 T4337 T4335 xcomp confirm,performed
R3412 T4338 T4340 nmod NFκB,specificity
R3413 T4339 T4340 amod binding,specificity
R3414 T4340 T4337 dobj specificity,confirm
R3415 T4341 T4343 mark as,described
R3416 T4342 T4343 advmod previously,described
R3417 T4343 T4340 advcl described,specificity
R3418 T4344 T4335 punct .,performed
R3459 T4426 T4426 ROOT 2.7,2.7
R3460 T4427 T4426 punct .,2.7
R3461 T4428 T4429 compound Statistical,Analysis
R3462 T4429 T4430 compound Analysis,All
R3463 T4430 T4431 compound All,data
R3464 T4431 T4433 nsubjpass data,presented
R3465 T4432 T4433 auxpass were,presented
R3466 T4433 T4433 ROOT presented,presented
R3467 T4434 T4433 prep as,presented
R3468 T4435 T4437 amod mean,SEM
R3469 T4436 T4437 compound ±,SEM
R3470 T4437 T4434 pobj SEM,as
R3471 T4438 T4433 punct .,presented
R3472 T4439 T4440 det The,measurements
R3473 T4440 T4442 nsubjpass measurements,analyzed
R3474 T4441 T4442 auxpass were,analyzed
R3475 T4442 T4442 ROOT analyzed,analyzed
R3476 T4443 T4442 agent by,analyzed
R3477 T4444 T4445 amod one-way,analysis
R3478 T4445 T4443 pobj analysis,by
R3479 T4446 T4445 prep of,analysis
R3480 T4447 T4446 pobj variance,of
R3481 T4448 T4449 punct (,ANOVA
R3482 T4449 T4447 appos ANOVA,variance
R3483 T4450 T4449 punct ),ANOVA
R3484 T4451 T4447 cc or,variance
R3485 T4452 T4454 poss Student,t-test
R3486 T4453 T4452 case 's,Student
R3487 T4454 T4442 npadvmod t-test,analyzed
R3488 T4455 T4442 punct .,analyzed
R3489 T4456 T4460 det The,level
R3490 T4457 T4460 nmod P,level
R3491 T4458 T4460 nmod <,level
R3492 T4459 T4458 nummod .05,<
R3493 T4460 T4464 nsubjpass level,used
R3494 T4461 T4460 prep of,level
R3495 T4462 T4461 pobj probability,of
R3496 T4463 T4464 auxpass was,used
R3497 T4464 T4464 ROOT used,used
R3498 T4465 T4464 prep as,used
R3499 T4466 T4467 det the,criteria
R3500 T4467 T4465 pobj criteria,as
R3501 T4468 T4467 prep of,criteria
R3502 T4469 T4468 pobj significance,of
R3503 T4470 T4464 punct .,used
R3625 T4653 T4653 ROOT 3.1,3.1
R3626 T4654 T4653 punct .,3.1
R3627 T4655 T4656 nummod TLR4,mRNA
R3628 T4656 T4657 nsubj mRNA,Increased
R3629 T4657 T4657 ROOT Increased,Increased
R3630 T4658 T4657 prep in,Increased
R3631 T4659 T4660 compound Brain,Tissue
R3632 T4660 T4658 pobj Tissue,in
R3633 T4661 T4667 mark after,detected
R3634 T4662 T4665 nmod ICH,levels
R3635 T4663 T4665 nummod TLR4,levels
R3636 T4664 T4665 compound mRNA,levels
R3637 T4665 T4667 nsubjpass levels,detected
R3638 T4666 T4667 auxpass were,detected
R3639 T4667 T4657 advcl detected,Increased
R3640 T4668 T4667 agent by,detected
R3641 T4669 T4668 pobj Rt-PCR,by
R3642 T4670 T4657 punct .,Increased
R3643 T4671 T4673 det The,level
R3644 T4672 T4673 amod low,level
R3645 T4673 T4678 nsubjpass level,observed
R3646 T4674 T4673 prep of,level
R3647 T4675 T4676 nummod TLR4,mRNA
R3648 T4676 T4674 pobj mRNA,of
R3649 T4677 T4678 auxpass was,observed
R3650 T4678 T4678 ROOT observed,observed
R3651 T4679 T4678 prep in,observed
R3652 T4680 T4683 amod normal,tissue
R3653 T4681 T4683 compound rat,tissue
R3654 T4682 T4683 compound brain,tissue
R3655 T4683 T4679 pobj tissue,in
R3656 T4684 T4678 punct .,observed
R3657 T4685 T4695 prep In,increased
R3658 T4686 T4689 det the,group
R3659 T4687 T4689 amod saline,group
R3660 T4688 T4689 compound control,group
R3661 T4689 T4685 pobj group,In
R3662 T4690 T4695 punct ",",increased
R3663 T4691 T4695 det the,increased
R3664 T4692 T4695 nummod TLR4,increased
R3665 T4693 T4695 nsubj mRNA,increased
R3666 T4694 T4695 advmod slightly,increased
R3667 T4695 T4695 ROOT increased,increased
R3668 T4696 T4695 punct ",",increased
R3669 T4697 T4695 cc but,increased
R3670 T4698 T4695 conj was,increased
R3671 T4699 T4698 neg not,was
R3672 T4700 T4701 advmod significantly,different
R3673 T4701 T4698 acomp different,was
R3674 T4702 T4701 prep from,different
R3675 T4703 T4704 amod normal,group
R3676 T4704 T4702 pobj group,from
R3677 T4705 T4695 punct .,increased
R3678 T4706 T4727 advmod However,peaked
R3679 T4707 T4727 punct ",",peaked
R3680 T4708 T4710 det the,mRNA
R3681 T4709 T4710 compound TLR4,mRNA
R3682 T4710 T4727 nsubj mRNA,peaked
R3683 T4711 T4714 mark after,increased
R3684 T4712 T4714 nsubj ICH,increased
R3685 T4713 T4714 advmod significantly,increased
R3686 T4714 T4727 advcl increased,peaked
R3687 T4715 T4727 advcl starting,peaked
R3688 T4716 T4715 prep from,starting
R3689 T4717 T4718 nummod 6,hours
R3690 T4718 T4716 pobj hours,from
R3691 T4719 T4727 mark after,peaked
R3692 T4720 T4727 nsubj ICH,peaked
R3693 T4721 T4720 punct (,ICH
R3694 T4722 T4725 nmod P,)
R3695 T4723 T4724 nummod <,.05
R3696 T4724 T4722 appos .05,P
R3697 T4725 T4720 punct ),ICH
R3698 T4726 T4727 punct ",",peaked
R3699 T4727 T4727 ROOT peaked,peaked
R3700 T4728 T4727 prep on,peaked
R3701 T4729 T4731 det the,day
R3702 T4730 T4731 amod 3rd,day
R3703 T4731 T4728 pobj day,on
R3704 T4732 T4731 prep after,day
R3705 T4733 T4732 pobj ICH,after
R3706 T4734 T4727 punct ",",peaked
R3707 T4735 T4727 cc and,peaked
R3708 T4736 T4737 advmod then,decreased
R3709 T4737 T4727 conj decreased,peaked
R3710 T4738 T4737 prep on,decreased
R3711 T4739 T4741 det the,day
R3712 T4740 T4741 amod 7th,day
R3713 T4741 T4738 pobj day,on
R3714 T4742 T4741 prep after,day
R3715 T4743 T4742 pobj ICH,after
R3716 T4744 T4743 punct (,ICH
R3717 T4745 T4743 appos P,ICH
R3718 T4746 T4745 nummod <,P
R3719 T4747 T4745 appos .05,P
R3720 T4748 T4745 punct ),P
R3721 T4749 T4743 punct ",",ICH
R3722 T4750 T4737 cc but,decreased
R3723 T4751 T4752 advmod still,maintained
R3724 T4752 T4737 conj maintained,decreased
R3725 T4753 T4755 det a,level
R3726 T4754 T4755 amod higher,level
R3727 T4755 T4752 dobj level,maintained
R3728 T4756 T4755 prep compared,level
R3729 T4757 T4756 prep with,compared
R3730 T4758 T4759 compound saline,control
R3731 T4759 T4757 pobj control,with
R3732 T4760 T4759 punct (,control
R3733 T4761 T4765 nmod P,Figure
R3734 T4762 T4761 nummod <,P
R3735 T4763 T4761 nummod .05,P
R3736 T4764 T4765 punct ",",Figure
R3737 T4765 T4759 appos Figure,control
R3738 T4766 T4765 nummod 1,Figure
R3739 T4767 T4759 punct ),control
R3740 T4768 T4727 punct .,peaked
R3974 T5127 T5128 poss Our,results
R3975 T5128 T5129 nsubj results,showed
R3976 T5129 T5129 ROOT showed,showed
R3977 T5130 T5137 mark that,was
R3978 T5131 T5133 det a,level
R3979 T5132 T5133 amod low,level
R3980 T5133 T5137 nsubj level,was
R3981 T5134 T5133 prep of,level
R3982 T5135 T5136 nummod TLR4,protein
R3983 T5136 T5134 pobj protein,of
R3984 T5137 T5129 ccomp was,showed
R3985 T5138 T5137 acomp detectable,was
R3986 T5139 T5138 prep in,detectable
R3987 T5140 T5143 det the,group
R3988 T5141 T5142 compound saline,control
R3989 T5142 T5143 compound control,group
R3990 T5143 T5139 pobj group,in
R3991 T5144 T5129 punct .,showed
R3992 T5145 T5146 det The,expression
R3993 T5146 T5150 nsubj expression,increased
R3994 T5147 T5146 prep of,expression
R3995 T5148 T5147 pobj TLR4,of
R3996 T5149 T5150 advmod significantly,increased
R3997 T5150 T5150 ROOT increased,increased
R3998 T5151 T5150 xcomp starting,increased
R3999 T5152 T5151 prep from,starting
R4000 T5153 T5154 nummod 6,hours
R4001 T5154 T5152 pobj hours,from
R4002 T5155 T5163 mark after,peaked
R4003 T5156 T5163 nsubj ICH,peaked
R4004 T5157 T5156 punct (,ICH
R4005 T5158 T5161 nmod P,)
R4006 T5159 T5158 nummod <,P
R4007 T5160 T5158 nummod .05,P
R4008 T5161 T5156 punct ),ICH
R4009 T5162 T5163 punct ",",peaked
R4010 T5163 T5151 advcl peaked,starting
R4011 T5164 T5163 prep on,peaked
R4012 T5165 T5167 det the,day
R4013 T5166 T5167 amod 3rd,day
R4014 T5167 T5164 pobj day,on
R4015 T5168 T5167 prep after,day
R4016 T5169 T5168 pobj ICH,after
R4017 T5170 T5163 punct ",",peaked
R4018 T5171 T5150 cc and,increased
R4019 T5172 T5173 advmod then,decreased
R4020 T5173 T5150 conj decreased,increased
R4021 T5174 T5173 cc but,decreased
R4022 T5175 T5176 advmod still,maintained
R4023 T5176 T5173 conj maintained,decreased
R4024 T5177 T5176 prep at,maintained
R4025 T5178 T5180 det a,level
R4026 T5179 T5180 amod high,level
R4027 T5180 T5177 pobj level,at
R4028 T5181 T5180 prep on,level
R4029 T5182 T5184 det the,day
R4030 T5183 T5184 amod 7th,day
R4031 T5184 T5181 pobj day,on
R4032 T5185 T5184 prep after,day
R4033 T5186 T5194 nmod ICH,)
R4034 T5187 T5188 punct (,P
R4035 T5188 T5194 nmod P,)
R4036 T5189 T5188 nummod <,P
R4037 T5190 T5188 nummod .05,P
R4038 T5191 T5192 punct ",",Figure
R4039 T5192 T5194 nmod Figure,)
R4040 T5193 T5192 nummod 2,Figure
R4041 T5194 T5180 punct ),level
R4042 T5195 T5150 punct .,increased
R4043 T5196 T5197 det This,observation
R4044 T5197 T5201 nsubj observation,was
R4045 T5198 T5197 prep of,observation
R4046 T5199 T5200 nummod TLR4,protein
R4047 T5200 T5198 pobj protein,of
R4048 T5201 T5201 ROOT was,was
R4049 T5202 T5201 acomp consistent,was
R4050 T5203 T5202 prep with,consistent
R4051 T5204 T5206 det the,profile
R4052 T5205 T5206 amod temporal,profile
R4053 T5206 T5203 pobj profile,with
R4054 T5207 T5206 prep of,profile
R4055 T5208 T5210 det the,mRNA
R4056 T5209 T5210 nummod TLR4,mRNA
R4057 T5210 T5207 pobj mRNA,of
R4058 T5211 T5201 prep after,was
R4059 T5212 T5211 pobj ICH,after
R4060 T5213 T5201 punct .,was
R4179 T5462 T5462 ROOT 3.3,3.3
R4180 T5463 T5462 punct .,3.3
R4181 T5464 T5483 advcl Distribution,detected
R4182 T5465 T5464 prep of,Distribution
R4183 T5466 T5465 pobj TLR4,of
R4184 T5467 T5464 prep in,Distribution
R4185 T5468 T5469 compound Brain,Subjected
R4186 T5469 T5467 pobj Subjected,in
R4187 T5470 T5464 prep to,Distribution
R4188 T5471 T5470 pobj ICH,to
R4189 T5472 T5473 aux To,explore
R4190 T5473 T5464 advcl explore,Distribution
R4191 T5474 T5475 det the,distribution
R4192 T5475 T5473 dobj distribution,explore
R4193 T5476 T5475 prep of,distribution
R4194 T5477 T5478 nummod TLR4,protein
R4195 T5478 T5476 pobj protein,of
R4196 T5479 T5483 punct ",",detected
R4197 T5480 T5481 det the,TLR4
R4198 T5481 T5483 nsubjpass TLR4,detected
R4199 T5482 T5483 auxpass was,detected
R4200 T5483 T5483 ROOT detected,detected
R4201 T5484 T5483 agent by,detected
R4202 T5485 T5484 pobj immunohistochemistry,by
R4203 T5486 T5487 punct (,IHC
R4204 T5487 T5485 appos IHC,immunohistochemistry
R4205 T5488 T5487 punct ),IHC
R4206 T5489 T5483 punct .,detected
R4207 T5490 T5491 nsubj Results,showed
R4208 T5491 T5491 ROOT showed,showed
R4209 T5492 T5495 mark that,was
R4210 T5493 T5494 nummod TLR4,immunoreactivity
R4211 T5494 T5495 nsubj immunoreactivity,was
R4212 T5495 T5491 ccomp was,showed
R4213 T5496 T5495 neg not,was
R4214 T5497 T5495 acomp detectable,was
R4215 T5498 T5497 prep in,detectable
R4216 T5499 T5500 compound brain,tissue
R4217 T5500 T5498 pobj tissue,in
R4218 T5501 T5500 prep from,tissue
R4219 T5502 T5505 amod normal,control
R4220 T5503 T5502 cc and,normal
R4221 T5504 T5502 conj sham,normal
R4222 T5505 T5501 pobj control,from
R4223 T5506 T5491 punct .,showed
R4224 T5507 T5514 advmod However,demonstrated
R4225 T5508 T5514 punct ",",demonstrated
R4226 T5509 T5514 nsubjpass immunoreactivity,demonstrated
R4227 T5510 T5509 prep for,immunoreactivity
R4228 T5511 T5510 pobj TLR4,for
R4229 T5512 T5514 auxpass was,demonstrated
R4230 T5513 T5514 advmod consistently,demonstrated
R4231 T5514 T5514 ROOT demonstrated,demonstrated
R4232 T5515 T5514 prep in,demonstrated
R4233 T5516 T5517 amod peri-hemorrhage,areas
R4234 T5517 T5515 pobj areas,in
R4235 T5518 T5514 punct ",",demonstrated
R4236 T5519 T5520 det the,hippocampus
R4237 T5520 T5514 dobj hippocampus,demonstrated
R4238 T5521 T5520 punct ",",hippocampus
R4239 T5522 T5520 conj cortex,hippocampus
R4240 T5523 T5522 punct ",",cortex
R4241 T5524 T5525 amod thalamic,nuclei
R4242 T5525 T5522 conj nuclei,cortex
R4243 T5526 T5525 punct ",",nuclei
R4244 T5527 T5525 cc and,nuclei
R4245 T5528 T5531 det some,tracts
R4246 T5529 T5530 amod white,matter
R4247 T5530 T5531 compound matter,tracts
R4248 T5531 T5525 conj tracts,nuclei
R4249 T5532 T5533 punct (,Figure
R4250 T5533 T5531 parataxis Figure,tracts
R4251 T5534 T5533 nummod 3,Figure
R4252 T5535 T5533 punct ),Figure
R4253 T5536 T5514 punct .,demonstrated
R4422 T5807 T5807 ROOT 3.4,3.4
R4423 T5808 T5807 punct .,3.4
R4424 T5809 T5817 nsubj Activation,induces
R4425 T5810 T5809 prep of,Activation
R4426 T5811 T5812 compound TLR4-Mediated,NF-Kappa-B
R4427 T5812 T5810 pobj NF-Kappa-B,of
R4428 T5813 T5814 compound Signaling,Activation
R4429 T5814 T5809 conj Activation,Activation
R4430 T5815 T5814 prep of,Activation
R4431 T5816 T5815 pobj TLR4,of
R4432 T5817 T5817 ROOT induces,induces
R4433 T5818 T5819 det the,phosphorylation
R4434 T5819 T5817 dobj phosphorylation,induces
R4435 T5820 T5819 prep of,phosphorylation
R4436 T5821 T5820 pobj inhibitor,of
R4437 T5822 T5821 prep of,inhibitor
R4438 T5823 T5822 pobj kappa-B,of
R4439 T5824 T5823 punct (,kappa-B
R4440 T5825 T5823 appos IκB,kappa-B
R4441 T5826 T5823 punct ),kappa-B
R4442 T5827 T5823 punct ",",kappa-B
R4443 T5828 T5829 nsubj which,dissociates
R4444 T5829 T5823 relcl dissociates,kappa-B
R4445 T5830 T5829 dobj IκB,dissociates
R4446 T5831 T5829 prep with,dissociates
R4447 T5832 T5831 pobj NF-kappa-B,with
R4448 T5833 T5832 punct (,NF-kappa-B
R4449 T5834 T5832 appos NFκB,NF-kappa-B
R4450 T5835 T5832 punct ),NF-kappa-B
R4451 T5836 T5817 punct .,induces
R4452 T5837 T5840 advmod Then,translocates
R4453 T5838 T5840 punct ",",translocates
R4454 T5839 T5840 nsubj NFκB,translocates
R4455 T5840 T5840 ROOT translocates,translocates
R4456 T5841 T5840 prep into,translocates
R4457 T5842 T5843 det the,nucleus
R4458 T5843 T5841 pobj nucleus,into
R4459 T5844 T5840 cc and,translocates
R4460 T5845 T5840 conj activates,translocates
R4461 T5846 T5845 cc and,activates
R4462 T5847 T5845 conj regulates,activates
R4463 T5848 T5849 det the,transcription
R4464 T5849 T5847 dobj transcription,regulates
R4465 T5850 T5849 prep of,transcription
R4466 T5851 T5850 pobj genes,of
R4467 T5852 T5851 acl related,genes
R4468 T5853 T5852 prep to,related
R4469 T5854 T5855 amod inflammatory,responses
R4470 T5855 T5853 pobj responses,to
R4471 T5856 T5840 punct .,translocates
R4472 T5857 T5858 aux To,detectd
R4473 T5858 T5880 advcl detectd,measured
R4474 T5859 T5860 det the,activation
R4475 T5860 T5858 dobj activation,detectd
R4476 T5861 T5860 prep of,activation
R4477 T5862 T5863 compound TLR4-mediated,NFκB
R4478 T5863 T5861 pobj NFκB,of
R4479 T5864 T5860 acl signaling,activation
R4480 T5865 T5880 punct ",",measured
R4481 T5866 T5867 det the,phosphorylation
R4482 T5867 T5880 nsubjpass phosphorylation,measured
R4483 T5868 T5867 prep of,phosphorylation
R4484 T5869 T5868 pobj inhibitor,of
R4485 T5870 T5869 prep of,inhibitor
R4486 T5871 T5870 pobj kappa-B,of
R4487 T5872 T5871 punct (,kappa-B
R4488 T5873 T5871 appos p-IκB,kappa-B
R4489 T5874 T5871 punct ),kappa-B
R4490 T5875 T5869 cc and,inhibitor
R4491 T5876 T5869 conj activity,inhibitor
R4492 T5877 T5869 prep of,inhibitor
R4493 T5878 T5877 pobj NFκB,of
R4494 T5879 T5880 auxpass were,measured
R4495 T5880 T5880 ROOT measured,measured
R4496 T5881 T5880 agent by,measured
R4497 T5882 T5881 pobj methods,by
R4498 T5883 T5882 prep of,methods
R4499 T5884 T5885 amod Western,Blots
R4500 T5885 T5883 pobj Blots,of
R4501 T5886 T5885 cc and,Blots
R4502 T5887 T5885 conj EMSA,Blots
R4503 T5888 T5880 punct .,measured
R4504 T5889 T5890 nsubj Results,showed
R4505 T5890 T5890 ROOT showed,showed
R4506 T5891 T5894 mark that,increased
R4507 T5892 T5893 det the,p-IκB
R4508 T5893 T5894 nsubj p-IκB,increased
R4509 T5894 T5890 ccomp increased,showed
R4510 T5895 T5894 prep at,increased
R4511 T5896 T5897 nummod 6,hours
R4512 T5897 T5895 pobj hours,at
R4513 T5898 T5906 mark after,peaked
R4514 T5899 T5906 nsubj ICH,peaked
R4515 T5900 T5899 punct (,ICH
R4516 T5901 T5904 nmod P,)
R4517 T5902 T5903 nummod <,.05
R4518 T5903 T5901 appos .05,P
R4519 T5904 T5899 punct ),ICH
R4520 T5905 T5906 punct ",",peaked
R4521 T5906 T5894 advcl peaked,increased
R4522 T5907 T5906 prep on,peaked
R4523 T5908 T5909 nummod 3,days
R4524 T5909 T5907 pobj days,on
R4525 T5910 T5906 prep after,peaked
R4526 T5911 T5910 pobj ICH,after
R4527 T5912 T5906 punct ",",peaked
R4528 T5913 T5906 cc and,peaked
R4529 T5914 T5906 conj maintained,peaked
R4530 T5915 T5917 det a,level
R4531 T5916 T5917 amod high,level
R4532 T5917 T5914 dobj level,maintained
R4533 T5918 T5914 prep on,maintained
R4534 T5919 T5920 nummod 7,days
R4535 T5920 T5918 pobj days,on
R4536 T5921 T5914 prep after,maintained
R4537 T5922 T5924 nmod ICH,P
R4538 T5923 T5922 punct (,ICH
R4539 T5924 T5921 pobj P,after
R4540 T5925 T5926 nummod <,.05
R4541 T5926 T5924 prep .05,P
R4542 T5927 T5928 punct ",",Figure
R4543 T5928 T5924 appos Figure,P
R4544 T5929 T5928 nummod 5,Figure
R4545 T5930 T5928 punct ),Figure
R4546 T5931 T5890 punct .,showed
R4547 T5932 T5933 mark As,expected
R4548 T5933 T5941 advcl expected,increased
R4549 T5934 T5941 punct ",",increased
R4550 T5935 T5936 det the,activity
R4551 T5936 T5941 nsubjpass activity,increased
R4552 T5937 T5936 prep of,activity
R4553 T5938 T5937 pobj NFκB,of
R4554 T5939 T5941 auxpass was,increased
R4555 T5940 T5941 advmod also,increased
R4556 T5941 T5941 ROOT increased,increased
R4557 T5942 T5941 prep in,increased
R4558 T5943 T5945 det the,manner
R4559 T5944 T5945 amod same,manner
R4560 T5945 T5942 pobj manner,in
R4561 T5946 T5945 prep as,manner
R4562 T5947 T5946 pobj that,as
R4563 T5948 T5947 prep of,that
R4564 T5949 T5950 det the,p-IκB
R4565 T5950 T5948 pobj p-IκB,of
R4566 T5951 T5952 punct (,Figure
R4567 T5952 T5947 appos Figure,that
R4568 T5953 T5952 nummod 4,Figure
R4569 T5954 T5952 punct ),Figure
R4570 T5955 T5941 punct .,increased
R5777 T7577 T7578 amod Intra-cerebral,hemorrhage
R5778 T7578 T7582 nsubj hemorrhage,represents
R5779 T7579 T7580 punct (,ICH
R5780 T7580 T7578 appos ICH,hemorrhage
R5781 T7581 T7578 punct ),hemorrhage
R5782 T7582 T7582 ROOT represents,represents
R5783 T7583 T7582 dobj 10,represents
R5784 T7584 T7585 nummod 15,%
R5785 T7585 T7583 appos %,10
R5786 T7586 T7585 prep of,%
R5787 T7587 T7588 det all,strokes
R5788 T7588 T7586 pobj strokes,of
R5789 T7589 T7582 punct ",",represents
R5790 T7590 T7582 cc and,represents
R5791 T7591 T7582 conj occurs,represents
R5792 T7592 T7591 prep with,occurs
R5793 T7593 T7594 amod increasing,frequency
R5794 T7594 T7592 pobj frequency,with
R5795 T7595 T7594 prep as,frequency
R5796 T7596 T7597 det a,complication
R5797 T7597 T7595 pobj complication,as
R5798 T7598 T7597 prep of,complication
R5799 T7599 T7601 det the,treatment
R5800 T7600 T7601 compound thrombolytic,treatment
R5801 T7601 T7598 pobj treatment,of
R5802 T7602 T7601 prep of,treatment
R5803 T7603 T7604 amod ischemic,stroke
R5804 T7604 T7602 pobj stroke,of
R5805 T7605 T7607 nmod [,]
R5806 T7606 T7607 nummod 1,]
R5807 T7607 T7597 appos ],complication
R5808 T7608 T7582 punct .,represents
R5809 T7609 T7610 det The,mortality
R5810 T7610 T7613 nsubj mortality,is
R5811 T7611 T7610 prep of,mortality
R5812 T7612 T7611 pobj ICH,of
R5813 T7613 T7613 ROOT is,is
R5814 T7614 T7613 acomp higher,is
R5815 T7615 T7614 prep than,higher
R5816 T7616 T7615 pobj that,than
R5817 T7617 T7616 prep of,that
R5818 T7618 T7619 amod ischemic,stroke
R5819 T7619 T7617 pobj stroke,of
R5820 T7620 T7613 punct .,is
R5821 T7621 T7622 advmod Only,31
R5822 T7622 T7623 nummod 31,%
R5823 T7623 T7624 nsubj %,are
R5824 T7624 T7624 ROOT are,are
R5825 T7625 T7626 advmod functionally,independent
R5826 T7626 T7624 acomp independent,are
R5827 T7627 T7624 prep at,are
R5828 T7628 T7629 nummod 3,months
R5829 T7629 T7627 pobj months,at
R5830 T7630 T7624 punct .,are
R5831 T7631 T7632 advmod Only,38
R5832 T7632 T7633 nummod 38,%
R5833 T7633 T7637 nsubj %,survive
R5834 T7634 T7633 prep of,%
R5835 T7635 T7636 det the,patients
R5836 T7636 T7634 pobj patients,of
R5837 T7637 T7637 ROOT survive,survive
R5838 T7638 T7640 det the,year
R5839 T7639 T7640 amod 1st,year
R5840 T7640 T7637 dobj year,survive
R5841 T7641 T7643 nmod [,]
R5842 T7642 T7643 nummod 10,]
R5843 T7643 T7640 appos ],year
R5844 T7644 T7637 punct .,survive
R5845 T7645 T7662 advmod Unfortunately,are
R5846 T7646 T7662 punct ",",are
R5847 T7647 T7648 det the,method
R5848 T7648 T7662 nsubj method,are
R5849 T7649 T7648 prep for,method
R5850 T7650 T7649 pobj treatment,for
R5851 T7651 T7650 prep of,treatment
R5852 T7652 T7653 det this,disease
R5853 T7653 T7651 pobj disease,of
R5854 T7654 T7653 cc and,disease
R5855 T7655 T7653 conj protection,disease
R5856 T7656 T7655 prep of,protection
R5857 T7657 T7659 det the,tissue
R5858 T7658 T7659 compound brain,tissue
R5859 T7659 T7656 pobj tissue,of
R5860 T7660 T7648 prep after,method
R5861 T7661 T7660 pobj ICH,after
R5862 T7662 T7662 ROOT are,are
R5863 T7663 T7662 neg not,are
R5864 T7664 T7662 acomp effective,are
R5865 T7665 T7662 punct .,are
R5866 T7666 T7667 compound Mass,effect
R5867 T7667 T7667 ROOT effect,effect
R5868 T7668 T7669 punct ",",ischemia
R5869 T7669 T7667 conj ischemia,effect
R5870 T7670 T7669 punct ",",ischemia
R5871 T7671 T7669 cc and,ischemia
R5872 T7672 T7669 conj toxicity,ischemia
R5873 T7673 T7672 prep of,toxicity
R5874 T7674 T7675 compound blood,components
R5875 T7675 T7673 pobj components,of
R5876 T7676 T7678 mark after,induce
R5877 T7677 T7678 nsubj ICH,induce
R5878 T7678 T7667 advcl induce,effect
R5880 T7680 T7681 compound tissue,damage
R5881 T7681 T7678 dobj damage,induce
R5882 T7682 T7667 punct .,effect
R5883 T7683 T7688 prep In,increasing
R5884 T7684 T7683 pobj addition,In
R5885 T7685 T7688 punct ",",increasing
R5886 T7686 T7687 expl there,is
R5887 T7687 T7688 aux is,increasing
R5888 T7688 T7688 ROOT increasing,increasing
R5889 T7689 T7688 dobj evidence,increasing
R5890 T7690 T7694 mark that,involved
R5891 T7691 T7692 amod inflammatory,processes
R5892 T7692 T7694 nsubjpass processes,involved
R5893 T7693 T7694 auxpass are,involved
R5894 T7694 T7689 acl involved,evidence
R5895 T7695 T7694 prep in,involved
R5896 T7696 T7697 amod cerebrovascular,events
R5897 T7697 T7695 pobj events,in
R5898 T7698 T7688 punct .,increasing
R5899 T7699 T7708 prep After,enter
R5900 T7700 T7699 pobj ICH,After
R5901 T7701 T7708 punct ",",enter
R5902 T7702 T7703 amod inflammatory,mediators
R5903 T7703 T7708 nsubj mediators,enter
R5904 T7704 T7703 prep from,mediators
R5905 T7705 T7706 det the,blood
R5906 T7706 T7704 pobj blood,from
R5907 T7707 T7708 aux might,enter
R5908 T7708 T7708 ROOT enter,enter
R5909 T7709 T7708 prep to,enter
R5910 T7710 T7711 det the,brain
R5911 T7711 T7709 pobj brain,to
R5912 T7712 T7708 cc and,enter
R5913 T7713 T7708 conj induce,enter
R5914 T7714 T7716 det an,reaction
R5915 T7715 T7716 amod inflammatory,reaction
R5916 T7716 T7713 dobj reaction,induce
R5917 T7717 T7716 cc and,reaction
R5918 T7718 T7720 det the,cells
R5919 T7719 T7720 compound brain,cells
R5920 T7720 T7716 conj cells,reaction
R5921 T7721 T7720 appos itself,cells
R5922 T7722 T7708 conj are,enter
R5923 T7723 T7722 advmod also,are
R5924 T7724 T7722 acomp capable,are
R5925 T7725 T7724 prep of,capable
R5926 T7726 T7725 pcomp producing,of
R5927 T7727 T7726 dobj many,producing
R5928 T7728 T7727 prep of,many
R5929 T7729 T7730 det these,agents
R5930 T7730 T7728 pobj agents,of
R5931 T7731 T7733 nmod [,]
R5932 T7732 T7733 nummod 11,]
R5933 T7733 T7726 dobj ],producing
R5934 T7734 T7722 punct .,are
R5935 T7735 T7737 det The,responses
R5936 T7736 T7737 amod inflammatory,responses
R5937 T7737 T7738 nsubj responses,are
R5939 T7738 T7738 ROOT are,are
R5941 T7739 T7738 acomp responsible,are
R5944 T7740 T7739 prep for,responsible
R5948 T7741 T7742 det the,ICH
R5952 T7742 T7743 nsubj ICH,induced
R5955 T7743 T7738 advcl induced,are
R5956 T7819 T7816 relcl initiates,factor
R5957 T7820 T7819 dobj transcription,initiates
R5958 T7821 T7820 prep of,transcription
R5959 T7822 T7821 pobj genes,of
R5960 T7744 T7745 compound brain,injury
R5961 T7823 T7822 acl associated,genes
R5962 T7745 T7743 dobj injury,induced
R5964 T7746 T7745 punct ",",injury
R5965 T7825 T7826 amod immune,responses
R5966 T7826 T7824 pobj responses,with
R5967 T7747 T7749 nsubj which,provide
R5968 T7827 T7826 cc and,responses
R5969 T7828 T7826 conj inflammation,responses
R5970 T7829 T7833 nmod [,]
R5971 T7830 T7832 dep 12,13
R5972 T7831 T7832 punct ",",13
R5973 T7832 T7833 nummod 13,]
R5974 T7748 T7749 aux could,provide
R5975 T7833 T7836 nsubj ],plays
R5976 T7834 T7833 cc and,]
R5977 T7749 T7745 relcl provide,injury
R5978 T7835 T7836 advmod also,plays
R5979 T7836 T7836 ROOT plays,plays
R5980 T7837 T7839 det a,role
R5981 T7838 T7839 amod key,role
R5982 T7750 T7752 amod new,targets
R5983 T7839 T7836 dobj role,plays
R5984 T7840 T7839 prep in,role
R5985 T7841 T7840 pcomp regulating,in
R5986 T7751 T7752 amod therapeutic,targets
R5987 T7842 T7841 dobj inflammation,regulating
R5988 T7843 T7842 prep in,inflammation
R5989 T7752 T7749 dobj targets,provide
R5990 T7844 T7845 compound brain,pathologies
R5991 T7845 T7843 pobj pathologies,in
R5992 T7846 T7836 punct .,plays
R5993 T7847 T7850 nsubjpass It,reported
R5994 T7753 T7752 prep for,targets
R5995 T7848 T7850 aux has,reported
R5996 T7849 T7850 auxpass been,reported
R5997 T7850 T7850 ROOT reported,reported
R5998 T7754 T7753 pobj ICH,for
R5999 T7851 T7853 mark that,increased
R6000 T7852 T7853 nsubj NFκB,increased
R6001 T7853 T7850 ccomp increased,reported
R6002 T7755 T7738 punct .,are
R6003 T7854 T7853 prep in,increased
R6004 T7855 T7856 det the,region
R6005 T7856 T7854 pobj region,in
R6006 T7756 T7757 amod Various,constituents
R6007 T7857 T7856 prep of,region
R6008 T7858 T7857 pobj perihematoma,of
R6009 T7859 T7853 prep after,increased
R6010 T7757 T7777 nsubj constituents,be
R6011 T7860 T7861 compound ICH,[
R6012 T7861 T7859 pobj [,after
R6013 T7862 T7863 nummod 14,]
R6014 T7758 T7757 prep of,constituents
R6015 T7863 T7861 appos ],[
R6016 T7864 T7850 punct .,reported
R6017 T7865 T7866 compound NFκB,activation
R6018 T7866 T7867 nsubj activation,occurs
R6019 T7867 T7867 ROOT occurs,occurs
R6020 T7868 T7867 prep within,occurs
R6021 T7869 T7868 pobj minutes,within
R6022 T7759 T7761 det the,response
R6023 T7870 T7867 cc and,occurs
R6024 T7871 T7867 conj persists,occurs
R6025 T7872 T7871 prep for,persists
R6026 T7873 T7874 advmod at,least
R6027 T7760 T7761 amod inflammatory,response
R6028 T7874 T7875 advmod least,a
R6029 T7875 T7876 nummod a,week
R6030 T7761 T7758 pobj response,of
R6031 T7876 T7872 pobj week,for
R6032 T7877 T7871 prep in,persists
R6033 T7878 T7877 pobj response,in
R6034 T7762 T7757 punct ",",constituents
R6035 T7879 T7878 prep to,response
R6036 T7880 T7879 pobj ICH,to
R6037 T7881 T7880 punct ",",ICH
R6038 T7882 T7884 nsubjpass which,associated
R6039 T7763 T7757 prep including,constituents
R6040 T7883 T7884 auxpass is,associated
R6041 T7884 T7880 relcl associated,ICH
R6042 T7885 T7884 prep with,associated
R6043 T7764 T7765 compound adhesion,molecules
R6044 T7886 T7887 det the,expression
R6045 T7887 T7885 pobj expression,with
R6046 T7888 T7887 prep of,expression
R6047 T7765 T7763 pobj molecules,including
R6048 T7889 T7891 amod selected,genes
R6049 T7890 T7891 compound target,genes
R6050 T7891 T7888 pobj genes,of
R6051 T7766 T7765 punct ",",molecules
R6052 T7892 T7894 nmod [,]
R6053 T7893 T7894 nummod 15,]
R6054 T7894 T7887 appos ],expression
R6055 T7767 T7765 conj cytokines,molecules
R6056 T7895 T7867 punct .,occurs
R6057 T7896 T7899 nsubj Activation,initiates
R6058 T7897 T7896 prep of,Activation
R6059 T7768 T7767 punct ",",cytokines
R6060 T7898 T7897 pobj NFκB,of
R6061 T7899 T7899 ROOT initiates,initiates
R6062 T7900 T7901 amod inflammatory,responses
R6063 T7769 T7767 conj leukocytes,cytokines
R6064 T7901 T7899 dobj responses,initiates
R6065 T7770 T7769 punct ",",leukocytes
R6066 T7902 T7899 cc and,initiates
R6067 T7903 T7899 conj contributes,initiates
R6068 T7771 T7769 conj immunoglobulins,leukocytes
R6069 T7772 T7771 punct ",",immunoglobulins
R6070 T7904 T7903 prep to,contributes
R6071 T7773 T7771 cc and,immunoglobulins
R6072 T7905 T7906 det the,pathobiology
R6073 T7906 T7904 pobj pathobiology,to
R6074 T7907 T7906 prep of,pathobiology
R6075 T7774 T7771 conj complement,immunoglobulins
R6076 T7908 T7910 amod perilesional,death
R6077 T7909 T7910 compound cell,death
R6078 T7775 T7774 punct ",",complement
R6079 T7910 T7907 pobj death,of
R6080 T7911 T7903 prep after,contributes
R6081 T7776 T7777 aux may,be
R6082 T7912 T7915 nmod ICH,]
R6083 T7913 T7915 nmod [,]
R6084 T7914 T7915 nummod 16,]
R6085 T7777 T7777 ROOT be,be
R6086 T7915 T7911 pobj ],after
R6087 T7916 T7899 punct .,initiates
R6088 T7917 T7923 nsubjpass Inhibition,shown
R6089 T7778 T7777 acomp important,be
R6090 T7918 T7917 prep of,Inhibition
R6091 T7919 T7920 compound NFκB,activity
R6092 T7920 T7918 pobj activity,of
R6093 T7779 T7777 prep in,be
R6094 T7921 T7923 aux has,shown
R6095 T7922 T7923 auxpass been,shown
R6096 T7923 T7923 ROOT shown,shown
R6097 T7780 T7781 det the,pathogenesis
R6098 T7924 T7925 aux to,have
R6099 T7925 T7923 xcomp have,shown
R6100 T7926 T7928 det a,effect
R6101 T7781 T7779 pobj pathogenesis,in
R6102 T7927 T7928 amod therapeutic,effect
R6103 T7928 T7925 dobj effect,have
R6104 T7929 T7928 prep on,effect
R6105 T7782 T7781 prep of,pathogenesis
R6106 T7930 T7931 amod experimental,ICH
R6107 T7931 T7929 pobj ICH,on
R6108 T7932 T7928 punct ",",effect
R6109 T7783 T7782 pobj ICH,of
R6110 T7933 T7934 amod such,as
R6111 T7934 T7928 prep as,effect
R6112 T7935 T7934 pobj reduce,as
R6113 T7784 T7777 punct .,be
R6114 T7936 T7935 dobj inflammation,reduce
R6115 T7937 T7936 punct ",",inflammation
R6116 T7938 T7939 amod behavioral,dysfunction
R6117 T7785 T7792 advmod However,activated
R6118 T7939 T7936 conj dysfunction,inflammation
R6119 T7940 T7939 punct ",",dysfunction
R6120 T7941 T7939 cc and,dysfunction
R6121 T7942 T7943 amod neuronal,damage
R6122 T7943 T7939 conj damage,dysfunction
R6123 T7944 T7943 acl produced,damage
R6124 T7786 T7792 punct ",",activated
R6125 T7945 T7944 agent by,produced
R6126 T7946 T7947 compound ICH,[
R6127 T7947 T7945 pobj [,by
R6128 T7787 T7792 advmod how,activated
R6129 T7948 T7949 nummod 17,]
R6130 T7949 T7947 appos ],[
R6131 T7950 T7923 punct .,shown
R6132 T7788 T7790 det the,responses
R6133 T7951 T7952 det The,knowledge
R6134 T7952 T7961 nsubj knowledge,subjected
R6135 T7953 T7952 prep about,knowledge
R6136 T7789 T7790 amod inflammatory,responses
R6137 T7954 T7957 advmod how,activated
R6138 T7955 T7957 nsubjpass NFκB,activated
R6139 T7956 T7957 auxpass is,activated
R6140 T7957 T7953 pcomp activated,about
R6141 T7790 T7792 nsubjpass responses,activated
R6142 T7958 T7957 prep in,activated
R6143 T7959 T7960 det the,brain
R6144 T7960 T7958 pobj brain,in
R6145 T7791 T7792 auxpass is,activated
R6146 T7792 T7792 ROOT activated,activated
R6147 T7793 T7792 cc and,activated
R6148 T7794 T7792 conj regulated,activated
R6149 T7795 T7794 prep in,regulated
R6150 T7961 T7964 csubj subjected,is
R6151 T7962 T7961 prep to,subjected
R6152 T7963 T7962 pobj ICH,to
R6153 T7796 T7798 det the,tissue
R6154 T7964 T7964 ROOT is,is
R6155 T7965 T7964 acomp critical,is
R6156 T7797 T7798 compound brain,tissue
R6157 T7966 T7965 prep for,critical
R6158 T7967 T7966 pcomp seeking,for
R6159 T7968 T7971 det a,method
R6160 T7969 T7971 amod new,method
R6161 T7798 T7795 pobj tissue,in
R6162 T7970 T7971 amod neuroprotective,method
R6163 T7971 T7967 dobj method,seeking
R6164 T7972 T7971 prep for,method
R6165 T7799 T7801 mark after,is
R6166 T7973 T7972 pobj ICH,for
R6167 T7974 T7964 punct .,is
R6168 T7975 T7976 amod Toll-like,receptors
R6169 T7800 T7801 nsubj ICH,is
R6170 T7976 T7980 nsubj receptors,are
R6171 T7977 T7976 punct (,receptors
R6172 T7978 T7976 appos TLRs,receptors
R6173 T7979 T7976 punct ),receptors
R6174 T7980 T7980 ROOT are,are
R6175 T7801 T7794 advcl is,regulated
R6176 T7802 T7801 acomp unclear,is
R6177 T7981 T7982 det a,family
R6178 T7982 T7980 attr family,are
R6179 T7803 T7792 punct .,activated
R6180 T7983 T7982 prep of,family
R6181 T7984 T7986 nmod signal,molecules
R6182 T7985 T7986 compound transduction,molecules
R6183 T7804 T7805 amod Transcription,factor
R6184 T7986 T7983 pobj molecules,of
R6185 T7987 T7982 cc and,family
R6186 T7988 T7980 conj play,are
R6187 T7805 T7811 nsubj factor,is
R6188 T7989 T7991 det a,role
R6189 T7806 T7807 amod nuclear,factor-kappa-B
R6190 T7990 T7991 amod critical,role
R6191 T7991 T7988 dobj role,play
R6192 T7992 T7988 prep in,play
R6193 T7993 T7994 det the,induction
R6194 T8058 T8049 conj ],diseases
R6195 T7994 T7992 pobj induction,in
R6196 T7995 T7994 prep of,induction
R6197 T7996 T7999 amod innate,immunity
R6198 T7997 T7996 cc and,innate
R6199 T8059 T8029 punct .,reported
R6200 T7998 T7996 conj adaptive,innate
R6201 T7999 T8000 compound immunity,[
R6202 T8000 T7995 pobj [,of
R6203 T8001 T8000 nummod 4,[
R6204 T8002 T7994 appos ],induction
R6205 T8003 T7980 punct .,are
R6206 T8060 T8063 mark Although,indicated
R6207 T8004 T8004 ROOT TLR-mediated,TLR-mediated
R6208 T8005 T8004 advcl signaling,TLR-mediated
R6209 T8006 T8008 nsubj pathways,stimulate
R6210 T8061 T8062 amod previous,reports
R6211 T8007 T8008 advmod mainly,stimulate
R6212 T8008 T8005 ccomp stimulate,signaling
R6213 T8009 T8010 det the,activation
R6214 T8062 T8063 nsubj reports,indicated
R6215 T8010 T8008 dobj activation,stimulate
R6216 T8011 T8010 prep of,activation
R6217 T8012 T8013 compound NFκB,[
R6218 T8063 T8096 advcl indicated,directed
R6219 T8013 T8011 pobj [,of
R6220 T8014 T8016 quantmod 12,13
R6221 T8015 T8016 punct ",",13
R6222 T8016 T8017 nummod 13,]
R6223 T8017 T8013 appos ],[
R6224 T8018 T8005 punct .,signaling
R6225 T8064 T8070 mark that,attributed
R6226 T8019 T8025 npadvmod TLR4,recognized
R6227 T8020 T8019 punct ",",TLR4
R6228 T8065 T8066 det the,activation
R6229 T8066 T8070 nsubjpass activation,attributed
R6230 T8021 T8024 det the,TLR
R6231 T8022 T8024 amod first,TLR
R6232 T8067 T8066 prep of,activation
R6233 T8023 T8024 amod mammalian,TLR
R6234 T8024 T8025 nsubj TLR,recognized
R6235 T8025 T8029 csubjpass recognized,reported
R6236 T8068 T8067 pobj NFκB,of
R6237 T8026 T8025 punct ",",recognized
R6238 T8027 T8029 aux has,reported
R6239 T8028 T8029 auxpass been,reported
R6240 T8029 T8029 ROOT reported,reported
R6241 T8030 T8032 aux to,involved
R6242 T8069 T8070 auxpass was,attributed
R6243 T8031 T8032 auxpass be,involved
R6244 T8032 T8029 xcomp involved,reported
R6245 T8033 T8032 prep in,involved
R6246 T8070 T8063 ccomp attributed,indicated
R6247 T8034 T8036 amod several,nervous
R6248 T8035 T8036 amod central,nervous
R6249 T8036 T8033 pobj nervous,in
R6250 T8071 T8070 prep to,attributed
R6251 T8037 T8036 punct (,nervous
R6252 T8038 T8040 nmod CNS,system
R6253 T8039 T8040 punct ),system
R6254 T8040 T8041 compound system,diseases
R6255 T8072 T8074 det the,stress
R6256 T8041 T8036 appos diseases,nervous
R6257 T8042 T8041 punct ",",diseases
R6258 T8043 T8044 amod such,as
R6259 T8073 T8074 amod oxidative,stress
R6260 T8044 T8041 prep as,diseases
R6261 T8045 T8049 amod inflammatory,diseases
R6262 T8046 T8045 cc or,inflammatory
R6263 T8047 T8045 conj autoimmune,inflammatory
R6264 T8074 T8071 pobj stress,to
R6265 T8048 T8045 conj CNS,inflammatory
R6266 T8049 T8044 pobj diseases,as
R6267 T8075 T8074 cc or,stress
R6268 T8050 T8049 cc and,diseases
R6269 T8051 T8058 amod cerebral,]
R6270 T8052 T8058 dep ischemic,]
R6271 T8053 T8054 compound injury,[
R6272 T8054 T8052 appos [,ischemic
R6273 T8055 T8054 nummod 7,[
R6274 T8056 T8058 punct ",",]
R6275 T8076 T8078 compound glutamate,activation
R6276 T8057 T8058 nummod 8,]
R6277 T8077 T8078 compound receptor,activation
R6278 T8078 T8074 conj activation,stress
R6279 T8079 T8078 acl induced,activation
R6280 T8080 T8079 agent by,induced
R6281 T8155 T8156 det These,changes
R6282 T8156 T8157 nsubj changes,started
R6283 T8081 T8083 amod red,cells
R6284 T8157 T8157 ROOT started,started
R6285 T8158 T8159 advmod as,early
R6286 T8159 T8157 advmod early,started
R6287 T8082 T8083 compound blood,cells
R6288 T8160 T8159 prep as,early
R6289 T8161 T8162 nummod 6,hours
R6290 T8083 T8080 pobj cells,by
R6291 T8162 T8163 npadvmod hours,after
R6292 T8163 T8160 prep after,as
R6293 T8164 T8166 det the,insult
R6294 T8084 T8083 cc and/or,cells
R6295 T8165 T8166 compound ICH,insult
R6296 T8166 T8163 pobj insult,after
R6297 T8167 T8157 cc and,started
R6298 T8085 T8086 compound plasma,constituents
R6299 T8168 T8157 conj maintained,started
R6300 T8169 T8168 prep at,maintained
R6301 T8170 T8172 det a,level
R6302 T8171 T8172 amod high,level
R6303 T8086 T8083 conj constituents,cells
R6304 T8172 T8169 pobj level,at
R6305 T8173 T8168 prep for,maintained
R6306 T8087 T8089 nmod [,]
R6307 T8174 T8175 nummod 7,days
R6308 T8175 T8173 pobj days,for
R6309 T8176 T8168 advmod afterward,maintained
R6310 T8088 T8089 nummod 17,]
R6311 T8177 T8157 punct .,started
R6312 T8178 T8180 det The,protein
R6313 T8179 T8180 nummod TLR4,protein
R6314 T8089 T8083 appos ],cells
R6315 T8180 T8188 nsubjpass protein,distributed
R6316 T8181 T8180 punct ",",protein
R6317 T8182 T8180 acl detected,protein
R6318 T8090 T8096 punct ",",directed
R6319 T8183 T8182 agent by,detected
R6320 T8184 T8183 pobj immunohistochemistry,by
R6321 T8185 T8180 punct ",",protein
R6322 T8186 T8188 auxpass was,distributed
R6323 T8187 T8188 advmod consistently,distributed
R6324 T8188 T8188 ROOT distributed,distributed
R6325 T8091 T8092 advmod very,few
R6326 T8189 T8188 prep in,distributed
R6327 T8190 T8191 amod peri-hemorrhage,areas
R6328 T8191 T8189 pobj areas,in
R6329 T8092 T8093 amod few,studies
R6330 T8192 T8188 punct ",",distributed
R6331 T8193 T8194 det the,hippocampus
R6332 T8093 T8096 nsubjpass studies,directed
R6333 T8194 T8188 dep hippocampus,distributed
R6334 T8195 T8194 punct ",",hippocampus
R6335 T8196 T8194 conj cortex,hippocampus
R6336 T8197 T8196 punct ",",cortex
R6337 T8094 T8096 aux have,directed
R6338 T8198 T8199 amod thalamic,nuclei
R6339 T8199 T8196 conj nuclei,cortex
R6340 T8200 T8199 punct ",",nuclei
R6341 T8095 T8096 auxpass been,directed
R6342 T8201 T8199 cc and,nuclei
R6343 T8202 T8205 det some,tracts
R6344 T8096 T8096 ROOT directed,directed
R6345 T8203 T8205 amod white,tracts
R6346 T8204 T8205 compound matter,tracts
R6347 T8205 T8199 conj tracts,nuclei
R6348 T8097 T8098 aux to,investigate
R6349 T8206 T8188 punct .,distributed
R6350 T8207 T8208 det These,data
R6351 T8208 T8209 nsubj data,indicated
R6352 T8098 T8096 xcomp investigate,directed
R6353 T8209 T8209 ROOT indicated,indicated
R6354 T8210 T8217 mark that,related
R6355 T8211 T8212 amod increased,expression
R6356 T8212 T8217 nsubjpass expression,related
R6357 T8099 T8100 det the,role
R6358 T8213 T8212 prep of,expression
R6359 T8214 T8213 pobj TLR4,of
R6360 T8215 T8217 aux may,related
R6361 T8100 T8098 dobj role,investigate
R6362 T8216 T8217 auxpass be,related
R6363 T8217 T8209 ccomp related,indicated
R6364 T8101 T8100 cc and,role
R6365 T8218 T8217 prep to,related
R6366 T8102 T8103 det the,relationship
R6367 T8219 T8220 det the,triggering
R6368 T8220 T8218 pobj triggering,to
R6369 T8221 T8220 prep of,triggering
R6370 T8222 T8224 det the,responses
R6371 T8223 T8224 amod inflammatory,responses
R6372 T8224 T8221 pobj responses,of
R6373 T8225 T8224 prep in,responses
R6374 T8103 T8100 conj relationship,role
R6375 T8226 T8228 det the,tissue
R6376 T8227 T8228 compound brain,tissue
R6377 T8104 T8103 prep between,relationship
R6378 T8228 T8225 pobj tissue,in
R6379 T8229 T8217 prep after,related
R6380 T8230 T8229 pobj ICH,after
R6381 T8105 T8106 compound TLR4-mediated,NFκB
R6382 T8231 T8209 punct .,indicated
R6383 T8232 T8233 amod Recent,studies
R6384 T8233 T8234 nsubj studies,demonstrated
R6385 T8106 T8104 pobj NFκB,between
R6386 T8234 T8234 ROOT demonstrated,demonstrated
R6387 T8235 T8237 mark that,initiates
R6388 T8236 T8237 nsubj ICH,initiates
R6389 T8237 T8234 ccomp initiates,demonstrated
R6390 T8107 T8104 pobj signaling,between
R6391 T8238 T8239 amod inflammatory,responses
R6392 T8239 T8237 dobj responses,initiates
R6393 T8240 T8239 punct ",",responses
R6394 T8108 T8107 cc and,signaling
R6395 T8241 T8243 nsubjpass which,associated
R6396 T8242 T8243 auxpass are,associated
R6397 T8243 T8239 relcl associated,responses
R6398 T8109 T8107 conj ICH,signaling
R6399 T8244 T8243 prep with,associated
R6400 T8245 T8246 amod secondary,growth
R6401 T8246 T8244 pobj growth,with
R6402 T8110 T8096 punct .,directed
R6403 T8247 T8246 prep of,growth
R6404 T8248 T8247 pobj hemorrhage,of
R6405 T8111 T8117 prep In,established
R6406 T8249 T8248 cc and,hemorrhage
R6407 T8250 T8251 compound cell,death
R6408 T8251 T8248 conj death,hemorrhage
R6409 T8112 T8114 det the,study
R6410 T8113 T8114 amod present,study
R6411 T8114 T8111 pobj study,In
R6412 T8252 T8254 nmod [,]
R6413 T8253 T8254 nummod 18,]
R6414 T8115 T8117 punct ",",established
R6415 T8254 T8246 appos ],growth
R6416 T8255 T8234 punct .,demonstrated
R6417 T8116 T8117 nsubj we,established
R6418 T8256 T8259 nsubjpass It,believed
R6419 T8257 T8259 auxpass is,believed
R6420 T8258 T8259 advmod now,believed
R6421 T8117 T8117 ROOT established,established
R6422 T8259 T8259 ROOT believed,believed
R6423 T8260 T8263 mark that,activates
R6424 T8261 T8262 amod TLR4-mediated-NFκB,pathway
R6425 T8262 T8263 nsubj pathway,activates
R6426 T8263 T8259 ccomp activates,believed
R6427 T8264 T8263 cc and,activates
R6428 T8265 T8263 conj regulates,activates
R6429 T8118 T8120 det the,model
R6430 T8266 T8269 amod immunological,responses
R6431 T8267 T8266 cc and,immunological
R6432 T8268 T8266 conj inflammatory,immunological
R6433 T8269 T8265 dobj responses,regulates
R6434 T8119 T8120 compound rat,model
R6435 T8270 T8259 punct .,believed
R6436 T8271 T8272 aux To,investigate
R6437 T8120 T8117 dobj model,established
R6438 T8272 T8292 advcl investigate,evaluated
R6439 T8273 T8274 det the,mechanisms
R6440 T8274 T8272 dobj mechanisms,investigate
R6441 T8275 T8274 acl underlying,mechanisms
R6442 T8121 T8120 prep of,model
R6443 T8276 T8279 det the,responses
R6444 T8122 T8123 amod experimental,ICH
R6445 T8277 T8279 amod increased,responses
R6446 T8278 T8279 amod inflammatory,responses
R6447 T8279 T8275 dobj responses,underlying
R6448 T8280 T8279 prep in,responses
R6449 T8281 T8282 det the,brain
R6450 T8123 T8121 pobj ICH,of
R6451 T8282 T8280 pobj brain,in
R6452 T8283 T8292 mark after,evaluated
R6453 T8284 T8292 nsubj ICH,evaluated
R6454 T8124 T8117 cc and,established
R6455 T8285 T8292 punct ",",evaluated
R6456 T8286 T8292 prep in,evaluated
R6457 T8287 T8289 det the,study
R6458 T8125 T8117 conj detected,established
R6459 T8288 T8289 amod present,study
R6460 T8289 T8286 pobj study,in
R6461 T8290 T8292 punct ",",evaluated
R6462 T8126 T8128 det the,mRNA
R6463 T8291 T8292 nsubj we,evaluated
R6464 T8292 T8292 ROOT evaluated,evaluated
R6465 T8293 T8294 det the,activation
R6466 T8294 T8292 dobj activation,evaluated
R6467 T8127 T8128 nummod TLR4,mRNA
R6468 T8295 T8294 prep of,activation
R6469 T8296 T8297 compound TLR4-mediated,NFκB
R6470 T8128 T8125 dobj mRNA,detected
R6471 T8129 T8128 cc and,mRNA
R6472 T8297 T8295 pobj NFκB,of
R6473 T8298 T8294 acl signaling,activation
R6474 T8299 T8292 prep by,evaluated
R6475 T8300 T8299 pcomp detecting,by
R6476 T8301 T8302 det the,p-IκB
R6477 T8302 T8300 dobj p-IκB,detecting
R6478 T8130 T8128 conj protein,mRNA
R6479 T8303 T8302 cc and,p-IκB
R6480 T8304 T8305 det the,activity
R6481 T8305 T8302 conj activity,p-IκB
R6482 T8131 T8117 punct .,established
R6483 T8306 T8305 prep of,activity
R6484 T8307 T8306 pobj NFκB,of
R6485 T8132 T8133 poss Our,data
R6486 T8308 T8305 prep in,activity
R6487 T8309 T8310 amod hemorrhagic,brains
R6488 T8310 T8308 pobj brains,in
R6489 T8133 T8134 nsubj data,showed
R6490 T8311 T8292 punct .,evaluated
R6491 T8312 T8313 nsubj NFκB,is
R6492 T8134 T8134 ROOT showed,showed
R6493 T8313 T8313 ROOT is,is
R6494 T8314 T8317 det an,factor
R6495 T8315 T8317 amod important,factor
R6496 T8135 T8136 det that,transcription
R6497 T8316 T8317 compound transcription,factor
R6498 T8317 T8313 attr factor,is
R6499 T8136 T8134 dobj transcription,showed
R6500 T8318 T8317 amod downstream,factor
R6501 T8319 T8318 prep in,downstream
R6502 T8320 T8323 det the,pathway
R6503 T8321 T8323 amod TLR4-mediated,pathway
R6504 T8137 T8136 prep of,transcription
R6505 T8322 T8323 amod signaling,pathway
R6506 T8323 T8319 pobj pathway,in
R6507 T8138 T8137 pobj TLR4,of
R6508 T8324 T8313 punct .,is
R6509 T8325 T8328 nsubj Activation,stimulates
R6510 T8326 T8325 prep of,Activation
R6511 T8139 T8141 advmod as,as
R6512 T8327 T8328 nummod TLR4,stimulates
R6513 T8328 T8328 ROOT stimulates,stimulates
R6514 T8329 T8330 compound IκBα,phosphorylation
R6515 T8330 T8328 dobj phosphorylation,stimulates
R6516 T8140 T8141 advmod well,as
R6517 T8331 T8330 cc and,phosphorylation
R6518 T8332 T8330 conj degradation,phosphorylation
R6519 T8333 T8330 punct ",",phosphorylation
R6520 T8141 T8136 cc as,transcription
R6521 T8334 T8328 advcl resulting,stimulates
R6522 T8335 T8334 prep in,resulting
R6523 T8336 T8337 amod nuclear,translocation
R6524 T8337 T8335 pobj translocation,in
R6525 T8338 T8337 prep of,translocation
R6526 T8339 T8338 pobj NFκB,of
R6527 T8340 T8339 punct ",",NFκB
R6528 T8142 T8143 det the,expression
R6529 T8341 T8342 nsubj which,initiates
R6530 T8342 T8339 relcl initiates,NFκB
R6531 T8343 T8342 dobj transcription,initiates
R6532 T8143 T8136 conj expression,transcription
R6533 T8344 T8343 prep of,transcription
R6534 T8345 T8344 pobj genes,of
R6535 T8346 T8345 acl associated,genes
R6536 T8144 T8143 prep of,expression
R6537 T8347 T8346 prep with,associated
R6538 T8348 T8350 amod innate,responses
R6539 T8145 T8146 nummod TLR4,protein
R6540 T8146 T8144 pobj protein,of
R6541 T8147 T8150 mark after,elevated
R6542 T8148 T8150 nsubj ICH,elevated
R6543 T8349 T8350 amod immune,responses
R6544 T8350 T8347 pobj responses,with
R6545 T8149 T8150 advmod significantly,elevated
R6546 T8351 T8350 cc and,responses
R6547 T8352 T8353 compound inflammation,[
R6548 T8353 T8350 conj [,responses
R6549 T8150 T8136 acl elevated,transcription
R6550 T8354 T8353 nummod 5,[
R6551 T8355 T8356 punct ",",6
R6552 T8151 T8150 prep in,elevated
R6553 T8356 T8357 nummod 6,]
R6554 T8357 T8353 appos ],[
R6555 T8358 T8328 punct .,stimulates
R6556 T8152 T8153 compound brain,tissue
R6557 T8359 T8360 nsubj We,observed
R6558 T8360 T8360 ROOT observed,observed
R6559 T8361 T8375 mark that,increased
R6560 T8362 T8363 det the,levels
R6561 T8153 T8151 pobj tissue,in
R6562 T8363 T8375 nsubjpass levels,increased
R6563 T8364 T8363 prep of,levels
R6564 T8365 T8364 pobj phosphorylation,of
R6565 T8154 T8134 punct .,showed
R6566 T8366 T8365 prep of,phosphorylation
R6567 T8367 T8366 pobj IκB,of
R6568 T8368 T8365 cc and,phosphorylation
R6569 T8446 T8447 amod microbial,components
R6570 T8369 T8370 det the,activity
R6571 T8370 T8365 conj activity,phosphorylation
R6572 T8371 T8370 prep of,activity
R6573 T8372 T8371 pobj NFκB,of
R6574 T8373 T8375 auxpass were,increased
R6575 T8374 T8375 advmod significantly,increased
R6576 T8375 T8360 ccomp increased,observed
R6577 T8447 T8445 pobj components,of
R6578 T8448 T8456 nsubj [,recognize
R6579 T8376 T8375 prep in,increased
R6580 T8377 T8378 compound brain,tissue
R6581 T8378 T8376 pobj tissue,in
R6582 T8449 T8448 nummod 19,[
R6583 T8379 T8375 prep after,increased
R6584 T8380 T8379 pobj ICH,after
R6585 T8381 T8360 punct .,observed
R6586 T8450 T8448 punct ",",[
R6587 T8382 T8384 det The,profile
R6588 T8383 T8384 amod temporal,profile
R6589 T8451 T8452 nummod 20,]
R6590 T8384 T8395 nsubj profile,was
R6591 T8385 T8384 prep of,profile
R6592 T8386 T8387 det the,expression
R6593 T8452 T8448 appos ],[
R6594 T8453 T8452 cc and,]
R6595 T8454 T8456 aux can,recognize
R6596 T8387 T8385 pobj expression,of
R6597 T8455 T8456 advmod also,recognize
R6598 T8388 T8387 prep of,expression
R6599 T8389 T8388 pobj p-IκB,of
R6600 T8390 T8387 cc and,expression
R6601 T8391 T8392 det the,activation
R6602 T8392 T8395 nsubj activation,was
R6603 T8456 T8456 ROOT recognize,recognize
R6604 T8393 T8392 prep of,activation
R6605 T8394 T8393 pobj NFκB,of
R6606 T8395 T8395 ROOT was,was
R6607 T8396 T8395 acomp similar,was
R6608 T8457 T8458 amod endogenous,molecules
R6609 T8397 T8396 prep to,similar
R6610 T8398 T8397 pobj that,to
R6611 T8399 T8398 prep of,that
R6612 T8458 T8456 dobj molecules,recognize
R6613 T8400 T8401 det the,expression
R6614 T8401 T8399 pobj expression,of
R6615 T8402 T8401 prep of,expression
R6616 T8459 T8460 amod such,as
R6617 T8403 T8402 pobj TLR4,of
R6618 T8404 T8395 punct .,was
R6619 T8405 T8406 poss Our,data
R6620 T8460 T8458 prep as,molecules
R6621 T8406 T8407 nsubj data,suggest
R6622 T8407 T8407 ROOT suggest,suggest
R6623 T8408 T8410 mark that,stimulates
R6624 T8409 T8410 nsubj ICH,stimulates
R6625 T8410 T8407 ccomp stimulates,suggest
R6626 T8411 T8410 dobj activation,stimulates
R6627 T8412 T8411 prep of,activation
R6628 T8461 T8463 det the,products
R6629 T8413 T8417 det the,pathway
R6630 T8414 T8415 nummod TLR4/NF,κB
R6631 T8415 T8417 nmod κB,pathway
R6632 T8462 T8463 compound degradation,products
R6633 T8416 T8417 amod signaling,pathway
R6634 T8417 T8412 pobj pathway,of
R6635 T8418 T8417 punct ",",pathway
R6636 T8419 T8420 nsubj which,is
R6637 T8463 T8460 pobj products,as
R6638 T8420 T8417 relcl is,pathway
R6639 T8421 T8420 acomp consistent,is
R6640 T8422 T8421 prep with,consistent
R6641 T8464 T8463 prep of,products
R6642 T8423 T8424 amod previous,reports
R6643 T8424 T8422 pobj reports,with
R6644 T8425 T8430 mark that,regulated
R6645 T8426 T8430 nsubjpass activation,regulated
R6646 T8465 T8464 pobj macromolecules,of
R6647 T8427 T8426 prep of,activation
R6648 T8428 T8427 pobj NFκB,of
R6649 T8429 T8430 auxpass is,regulated
R6650 T8466 T8463 punct ",",products
R6651 T8430 T8424 acl regulated,reports
R6652 T8431 T8430 prep through,regulated
R6653 T8432 T8435 det the,pathway
R6654 T8467 T8463 conj products,products
R6655 T8433 T8435 amod TLR4-mediated,pathway
R6656 T8434 T8435 amod signaling,pathway
R6657 T8435 T8431 pobj pathway,through
R6658 T8468 T8463 prep of,products
R6659 T8436 T8407 punct .,suggest
R6660 T8437 T8438 nsubj TLR4,plays
R6661 T8469 T8470 amod proteolytic,cascades
R6662 T8438 T8438 ROOT plays,plays
R6663 T8439 T8441 det an,role
R6664 T8440 T8441 amod important,role
R6665 T8441 T8438 dobj role,plays
R6666 T8470 T8468 pobj cascades,of
R6667 T8442 T8441 prep in,role
R6668 T8443 T8444 det the,recognition
R6669 T8444 T8442 pobj recognition,in
R6670 T8471 T8470 punct ",",cascades
R6671 T8445 T8444 prep of,recognition
R6672 T8472 T8473 amod intracellular,components
R6673 T8473 T8463 conj components,products
R6674 T8474 T8473 prep of,components
R6675 T8543 T8544 compound blood,cells
R6676 T8475 T8476 amod ruptured,cells
R6677 T8544 T8542 pobj cells,from
R6678 T8545 T8544 cc and,cells
R6679 T8476 T8474 pobj cells,of
R6680 T8546 T8544 conj constituents,cells
R6681 T8547 T8544 prep of,cells
R6682 T8548 T8549 compound plasma,server
R6683 T8477 T8473 punct ",",components
R6684 T8549 T8547 pobj server,of
R6685 T8550 T8541 prep as,came
R6686 T8551 T8553 amod endogenous,ligands
R6687 T8478 T8473 cc and,components
R6688 T8552 T8553 nummod TLR4,ligands
R6689 T8553 T8550 pobj ligands,as
R6690 T8554 T8541 punct ",",came
R6691 T8479 T8473 conj products,components
R6692 T8555 T8532 conj activate,speculated
R6693 T8556 T8557 compound TLR4-mediated,NFκB
R6694 T8557 T8558 nsubj NFκB,signaling
R6695 T8480 T8479 prep of,products
R6696 T8558 T8555 ccomp signaling,activate
R6697 T8559 T8558 punct ",",signaling
R6698 T8481 T8480 pobj genes,of
R6699 T8560 T8555 cc and,activate
R6700 T8561 T8555 conj initiate,activate
R6701 T8562 T8564 det the,responses
R6702 T8482 T8484 nsubjpass that,activated
R6703 T8563 T8564 amod inflammatory,responses
R6704 T8564 T8561 dobj responses,initiate
R6705 T8565 T8564 prep in,responses
R6706 T8483 T8484 auxpass are,activated
R6707 T8566 T8567 compound IHC,brain
R6708 T8567 T8565 pobj brain,in
R6709 T8568 T8532 punct .,speculated
R6710 T8484 T8463 relcl activated,products
R6711 T8569 T8583 advmod However,determined
R6712 T8570 T8583 punct ",",determined
R6713 T8485 T8484 agent by,activated
R6714 T8571 T8574 det the,ligands
R6715 T8572 T8574 amod specific,ligands
R6716 T8573 T8574 compound endogenous,ligands
R6717 T8574 T8583 nsubjpass ligands,determined
R6718 T8486 T8485 pobj inflammation,by
R6719 T8575 T8574 prep for,ligands
R6720 T8576 T8575 pobj TLR4,for
R6721 T8577 T8576 prep in,TLR4
R6722 T8487 T8456 punct .,recognize
R6723 T8488 T8498 prep For,enzymes
R6724 T8489 T8488 pobj instance,For
R6725 T8578 T8579 amod hemorrhagic,brain
R6726 T8579 T8577 pobj brain,in
R6727 T8580 T8583 aux have,determined
R6728 T8581 T8583 neg not,determined
R6729 T8582 T8583 auxpass been,determined
R6730 T8490 T8498 punct ",",enzymes
R6731 T8583 T8583 ROOT determined,determined
R6732 T8584 T8583 cc and,determined
R6733 T8585 T8583 conj need,determined
R6734 T8491 T8498 nsubj HSP70,enzymes
R6735 T8586 T8588 aux to,identified
R6736 T8587 T8588 auxpass be,identified
R6737 T8588 T8585 xcomp identified,need
R6738 T8492 T8491 punct ",",HSP70
R6739 T8589 T8588 prep through,identified
R6740 T8590 T8591 amod further,research
R6741 T8591 T8589 pobj research,through
R6742 T8592 T8583 punct .,determined
R6743 T8493 T8491 conj HSP32,HSP70
R6744 T8593 T8599 prep In,demonstrated
R6745 T8594 T8593 pobj conclusion,In
R6746 T8595 T8599 punct ",",demonstrated
R6747 T8494 T8493 punct ",",HSP32
R6748 T8596 T8598 det the,study
R6749 T8597 T8598 amod present,study
R6750 T8495 T8493 conj HSP27,HSP32
R6751 T8598 T8599 nsubj study,demonstrated
R6752 T8599 T8599 ROOT demonstrated,demonstrated
R6753 T8600 T8602 det the,profile
R6754 T8601 T8602 amod temporal,profile
R6755 T8496 T8495 punct ",",HSP27
R6756 T8602 T8599 dobj profile,demonstrated
R6757 T8603 T8602 prep of,profile
R6758 T8604 T8605 det the,activation
R6759 T8497 T8495 cc and,HSP27
R6760 T8605 T8603 pobj activation,of
R6761 T8606 T8605 prep of,activation
R6762 T8498 T8498 ROOT enzymes,enzymes
R6763 T8607 T8608 compound TLR4-mediated,NFκB
R6764 T8608 T8606 pobj NFκB,of
R6765 T8609 T8602 acl signaling,profile
R6766 T8610 T8609 prep in,signaling
R6767 T8499 T8498 acl involved,enzymes
R6768 T8611 T8612 compound brain,tissue
R6769 T8612 T8610 pobj tissue,in
R6770 T8500 T8499 prep in,involved
R6771 T8501 T8502 amod oxidative,stress
R6772 T8613 T8612 prep in,tissue
R6773 T8502 T8500 pobj stress,in
R6774 T8614 T8616 det a,model
R6775 T8615 T8616 compound rat,model
R6776 T8616 T8613 pobj model,in
R6777 T8617 T8616 prep of,model
R6778 T8618 T8619 amod experimental,ICH
R6779 T8619 T8617 pobj ICH,of
R6780 T8503 T8504 auxpass are,found
R6781 T8620 T8619 punct ",",ICH
R6782 T8621 T8622 nsubj which,suggests
R6783 T8504 T8498 conj found,enzymes
R6784 T8622 T8602 relcl suggests,profile
R6785 T8623 T8627 mark that,participates
R6786 T8624 T8625 compound TLR4-mediated,NFκB
R6787 T8625 T8627 nsubj NFκB,participates
R6788 T8505 T8507 aux to,upregulated
R6789 T8626 T8625 acl signaling,NFκB
R6790 T8627 T8622 ccomp participates,suggests
R6791 T8506 T8507 auxpass be,upregulated
R6792 T8628 T8627 prep in,participates
R6793 T8629 T8630 det the,pathogenesis
R6794 T8630 T8628 pobj pathogenesis,in
R6795 T8631 T8630 prep of,pathogenesis
R6796 T8507 T8504 xcomp upregulated,found
R6797 T8632 T8631 pobj ICH,of
R6798 T8633 T8632 punct ",",ICH
R6799 T8634 T8636 nsubj which,be
R6800 T8508 T8507 prep in,upregulated
R6801 T8635 T8636 aux may,be
R6802 T8636 T8630 relcl be,pathogenesis
R6803 T8637 T8639 det a,target
R6804 T8509 T8510 det the,brain
R6805 T8638 T8639 amod therapeutic,target
R6806 T8639 T8636 attr target,be
R6807 T8510 T8508 pobj brain,in
R6808 T8511 T8507 prep after,upregulated
R6809 T8640 T8639 prep for,target
R6810 T8512 T8511 pobj ICH,after
R6811 T8641 T8642 det the,prevention
R6812 T8642 T8640 pobj prevention,for
R6813 T8643 T8642 prep of,prevention
R6814 T8513 T8512 punct ",",ICH
R6815 T8644 T8646 amod ICH-induced,damage
R6816 T8645 T8646 compound brain,damage
R6817 T8646 T8643 pobj damage,of
R6818 T8514 T8517 nsubjpass which,produced
R6819 T8647 T8599 punct .,demonstrated
R6820 T8515 T8517 aux may,produced
R6821 T8516 T8517 auxpass be,produced
R6822 T8517 T8512 relcl produced,ICH
R6823 T8518 T8517 agent by,produced
R6824 T8519 T8521 amod injured,cells
R6825 T8520 T8521 amod neuronal,cells
R6826 T8521 T8518 pobj cells,by
R6827 T8522 T8521 cc or,cells
R6828 T8523 T8524 compound blood,cells
R6829 T8524 T8521 conj cells,cells
R6830 T8525 T8527 nmod [,]
R6831 T8526 T8527 nummod 21,]
R6832 T8527 T8521 appos ],cells
R6833 T8528 T8498 punct .,enzymes
R6834 T8529 T8532 nsubjpass It,speculated
R6835 T8530 T8532 aux may,speculated
R6836 T8531 T8532 auxpass be,speculated
R6837 T8532 T8532 ROOT speculated,speculated
R6838 T8533 T8541 mark that,came
R6839 T8534 T8535 det these,molecules
R6840 T8535 T8541 nsubj molecules,came
R6841 T8536 T8535 acl produced,molecules
R6842 T8537 T8536 prep in,produced
R6843 T8538 T8539 amod damaged,brain
R6844 T8539 T8537 pobj brain,in
R6845 T8540 T8536 cc or,produced
R6848 T8541 T8532 ccomp came,speculated
R6850 T8542 T8541 prep from,came
R2171 T2660 T2663 nummod 75,saline
R3930 T5083 T5083 ROOT 3.2,3.2
R3931 T5084 T5083 punct .,3.2
R3932 T5085 T5089 nsubj Expression,Increased
R3933 T5086 T5085 prep of,Expression
R3934 T5087 T5088 nummod TLR4,Protein
R3935 T5088 T5086 pobj Protein,of
R3936 T5089 T5089 ROOT Increased,Increased
R3937 T5090 T5089 prep in,Increased
R3938 T5091 T5092 compound Brain,Tissue
R3939 T5092 T5090 pobj Tissue,in
R3940 T5093 T5096 mark after,investigate
R3941 T5094 T5096 nsubj ICH,investigate
R3942 T5095 T5096 aux To,investigate
R3943 T5096 T5089 advcl investigate,Increased
R3944 T5097 T5099 det the,TLR4
R3945 T5098 T5099 amod increased,TLR4
R3946 T5099 T5096 dobj TLR4,investigate
R3947 T5100 T5096 prep at,investigate
R3948 T5101 T5103 det the,level
R3949 T5102 T5103 compound protein,level
R3950 T5103 T5100 pobj level,at
R3951 T5104 T5096 punct ",",investigate
R3952 T5105 T5106 det the,expression
R3953 T5106 T5096 dobj expression,investigate
R3954 T5107 T5106 prep of,expression
R3955 T5108 T5109 nummod TLR4,protein
R3956 T5109 T5107 pobj protein,of
R3957 T5110 T5111 auxpass was,measured
R3958 T5111 T5096 conj measured,investigate
R3959 T5112 T5111 prep in,measured
R3960 T5113 T5114 compound brain,tissue
R3961 T5114 T5112 pobj tissue,in
R3962 T5115 T5111 agent by,measured
R3963 T5116 T5117 det the,method
R3964 T5117 T5115 pobj method,by
R3965 T5118 T5117 prep of,method
R3966 T5119 T5120 amod Western,Blots
R3967 T5120 T5118 pobj Blots,of
R3968 T5121 T5111 advcl using,measured
R3969 T5122 T5123 amod specific,antibodies
R3970 T5123 T5121 dobj antibodies,using
R3971 T5124 T5121 prep for,using
R3972 T5125 T5124 pobj TLR4,for
R3973 T5126 T5089 punct .,Increased
R1271 T1632 T1631 pobj TLR4,of
R1272 T1633 T1630 cc and,distribution
R1273 T1634 T1636 det the,profile
R1274 T1635 T1636 amod temporal,profile
R1275 T1636 T1630 conj profile,distribution
R1276 T1637 T1636 prep of,profile
R1277 T1638 T1639 det the,activation
R1278 T1639 T1637 pobj activation,of
R1279 T1640 T1639 prep of,activation
R1280 T1641 T1642 amod TLR4-mediated,signaling
R1281 T1642 T1640 pobj signaling,of
R1282 T1643 T1639 prep in,activation
R1283 T1644 T1646 compound rat,tissue
R1284 T1645 T1646 compound brain,tissue
R1285 T1646 T1643 pobj tissue,in
R1286 T1647 T1630 prep after,distribution
R1287 T1648 T1647 pobj ICH,after
R1288 T1649 T1625 punct .,provided
R3255 T4181 T4181 ROOT 2.6,2.6
R3256 T4182 T4181 punct .,2.6
R3257 T4183 T4186 compound Electrophoretic,Assay
R3258 T4184 T4185 compound Mobility,Shift
R3259 T4185 T4186 compound Shift,Assay
R3260 T4186 T4193 nsubjpass Assay,isolated
R3261 T4187 T4188 punct (,EMSA
R3262 T4188 T4186 appos EMSA,Assay
R3263 T4189 T4188 punct ),EMSA
R3264 T4190 T4191 compound Nuclear,proteins
R3265 T4191 T4192 nsubj proteins,were
R3266 T4192 T4193 auxpass were,isolated
R3267 T4193 T4193 ROOT isolated,isolated
R3268 T4194 T4193 prep from,isolated
R3269 T4195 T4196 compound brain,tissue
R3270 T4196 T4194 pobj tissue,from
R3271 T4197 T4193 punct .,isolated
R3272 T4198 T4206 advmod Briefly,extract
R3273 T4199 T4206 punct ",",extract
R3274 T4200 T4206 prep after,extract
R3275 T4201 T4200 pobj removal,after
R3276 T4202 T4201 prep of,removal
R3277 T4203 T4202 pobj supernatant,of
R5879 T7679 T7681 compound brain,damage
R5938 T7807 T7811 nsubj factor-kappa-B,is
R5940 T7808 T7807 punct (,factor-kappa-B
R5942 T7809 T7807 appos NFκB,factor-kappa-B
R5943 T7810 T7807 punct ),factor-kappa-B
R5945 T7811 T7836 ccomp is,plays
R5946 T7812 T7816 det an,factor
R5947 T7813 T7816 amod important,factor
R5949 T7814 T7815 amod nuclear,transcription
R5950 T7815 T7816 compound transcription,factor
R5951 T7816 T7811 attr factor,is
R5953 T7817 T7816 punct ",",factor
R5954 T7818 T7819 nsubj which,initiates
R5963 T7824 T7823 prep with,associated
R3046 T3900 T3901 amod secondary,antibodies
R3047 T3901 T3898 pobj antibodies,with
R3048 T3902 T3901 punct (,antibodies
R3049 T3903 T3904 compound Golden,Bridge
R3050 T3904 T3901 appos Bridge,antibodies
R3051 T3905 T3904 punct ",",Bridge
R3052 T3906 T3904 appos PV-6001,Bridge
R3053 T3907 T3904 punct ),Bridge
R3054 T3908 T3884 punct .,incubated
R3055 T3909 T3910 det The,signals
R3056 T3910 T3912 nsubjpass signals,detected
R3057 T3911 T3912 auxpass were,detected
R3058 T3912 T3912 ROOT detected,detected
R3059 T3913 T3912 prep with,detected
R3060 T3914 T3916 det the,system
R3061 T3915 T3916 compound ECL,system
R3062 T3916 T3913 pobj system,with
R3063 T3917 T3916 punct (,system
R3064 T3918 T3919 compound Amersham,Pharmacia
R3065 T3919 T3916 appos Pharmacia,system

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T119 14-18 Protein denotes TLR4
T120 28-32 Protein denotes NFκB
T121 0-10 Positive_regulation denotes Activation
T6498 18150-18154 Protein denotes NFκB
T6497 18136-18140 Protein denotes TLR4
T6496 18049-18053 Protein denotes NFκB
T6495 18035-18039 Protein denotes TLR4
T6494 17844-17848 Protein denotes TLR4
T6493 17729-17733 Protein denotes NFκB
T6492 17715-17719 Protein denotes TLR4
T6491 17692-17696 Protein denotes TLR4
T6490 17446-17457 Positive_regulation denotes upregulated
T6489 17446-17457 Positive_regulation denotes upregulated
T6488 17446-17457 Positive_regulation denotes upregulated
T6487 17382-17387 Protein denotes HSP27
T6486 17375-17380 Protein denotes HSP32
T6485 17368-17373 Protein denotes HSP70
T6484 17135-17144 Binding denotes recognize
T6483 17041-17045 Protein denotes TLR4
T6482 16859-16869 Positive_regulation denotes stimulates
T6481 16859-16869 Positive_regulation denotes stimulates
T6480 16986-16995 Regulation denotes regulated
T6479 16964-16974 Positive_regulation denotes activation
T6478 16870-16880 Positive_regulation denotes activation
T6477 16870-16880 Positive_regulation denotes activation
T6476 17008-17012 Protein denotes TLR4
T6475 16978-16982 Protein denotes NFκB
T6474 16893-16897 Protein denotes NFκB
T6473 16888-16892 Protein denotes TLR4
T6472 16855-16858 Protein denotes ICH
T6471 16813-16823 Gene_expression denotes expression
T6470 16767-16777 Positive_regulation denotes activation
T6469 16767-16777 Positive_regulation denotes activation
T6468 16739-16749 Gene_expression denotes expression
T6467 16827-16831 Protein denotes TLR4
T6466 16781-16785 Protein denotes NFκB
T6465 16753-16758 Protein denotes p-IκB
T6464 16674-16683 Positive_regulation denotes increased
T6463 16607-16622 Phosphorylation denotes phosphorylation
T6462 16650-16654 Protein denotes NFκB
T6461 16626-16629 Protein denotes IκB
T6460 16379-16389 Positive_regulation denotes stimulates
T6459 16379-16389 Positive_regulation denotes stimulates
T6458 16449-16462 Localization denotes translocation
T6457 16441-16448 Entity denotes nuclear
T6456 16415-16426 Protein_catabolism denotes degradation
T6455 16395-16410 Phosphorylation denotes phosphorylation
T6454 16360-16370 Positive_regulation denotes Activation
T6453 16466-16470 Protein denotes NFκB
T6452 16390-16394 Protein denotes IκBα
T6451 16374-16378 Protein denotes TLR4
T6450 16327-16331 Protein denotes TLR4
T6449 16267-16271 Protein denotes NFκB
T6448 16199-16208 Gene_expression denotes detecting
T6447 16199-16208 Gene_expression denotes detecting
T6446 16239-16243 Protein denotes NFκB
T6445 16213-16218 Protein denotes p-IκB
T6444 16181-16185 Protein denotes NFκB
T6443 16167-16171 Protein denotes TLR4
T6442 15933-15937 Protein denotes NFκB
T6441 15919-15923 Protein denotes TLR4
T6440 15623-15632 Positive_regulation denotes increased
T6439 15633-15643 Gene_expression denotes expression
T6438 15647-15651 Protein denotes TLR4
T6437 15487-15498 Localization denotes distributed
T6436 15422-15434 Protein denotes TLR4 protein
T6435 15276-15284 Positive_regulation denotes elevated
T6434 15276-15284 Positive_regulation denotes elevated
T6433 15225-15235 Gene_expression denotes expression
T6432 15188-15201 Transcription denotes transcription
T6431 15239-15243 Protein denotes TLR4
T6430 15205-15209 Protein denotes TLR4
T6429 15131-15139 Gene_expression denotes detected
T6428 15144-15153 Protein denotes TLR4 mRNA
T6427 14778-14788 Positive_regulation denotes activation
T6426 15051-15054 Protein denotes ICH
T6425 15032-15036 Protein denotes NFκB
T6424 15018-15022 Protein denotes TLR4
T6423 14839-14857 Protein denotes glutamate receptor
T6422 14792-14796 Protein denotes NFκB
T6421 14523-14527 Protein denotes TLR4
T6420 14332-14361 Protein denotes signal transduction molecules
T6419 14187-14196 Positive_regulation denotes activated
T6418 14179-14183 Protein denotes NFκB
T6417 13967-13977 Negative_regulation denotes Inhibition
T6416 13981-13985 Protein denotes NFκB
T6415 13836-13846 Positive_regulation denotes Activation
T6414 13850-13854 Protein denotes NFκB
T6413 13679-13689 Positive_regulation denotes activation
T6412 13760-13763 Protein denotes ICH
T6411 13674-13678 Protein denotes NFκB
T6410 13613-13617 Protein denotes NFκB
T6409 13430-13443 Transcription denotes transcription
T6408 13362-13366 Protein denotes NFκB
T6407 13338-13360 Protein denotes nuclear factor-kappa-B
T6406 13130-13145 Protein denotes immunoglobulins
T5661 11962-11971 Positive_regulation denotes increased
T5660 12006-12011 Protein denotes p-IκB
T5659 11948-11952 Protein denotes NFκB
T5385 11112-11116 Protein denotes TLR4
T5384 10995-10999 Protein denotes TLR4
T5383 10892-10904 Transcription denotes distribution
T5382 10926-10930 Protein denotes TLR4
T5381 10908-10920 Protein denotes TLR4 protein
T5380 10830-10842 Transcription denotes Distribution
T5379 10846-10850 Protein denotes TLR4
T4532 10017-10026 Localization denotes decreased
T4531 9922-9931 Positive_regulation denotes increased
T4530 9888-9897 Protein denotes TLR4 mRNA
T4529 9809-9818 Positive_regulation denotes increased
T4528 9790-9799 Protein denotes TLR4 mRNA
T4527 9706-9715 Protein denotes TLR4 mRNA
T4526 9647-9656 Protein denotes TLR4 mRNA
T4525 9611-9620 Positive_regulation denotes Increased
T4524 9601-9610 Protein denotes TLR4 mRNA
T4949 10788-10795 Positive_regulation denotes profile
T4948 10727-10738 Positive_regulation denotes observation
T4947 10819-10822 Protein denotes ICH
T4946 10803-10812 Protein denotes TLR4 mRNA
T4945 10742-10754 Protein denotes TLR4 protein
T4944 10629-10638 Negative_regulation denotes decreased
T4943 10534-10543 Positive_regulation denotes increased
T4942 10501-10511 Gene_expression denotes expression
T4941 10515-10519 Protein denotes TLR4
T4940 10457-10467 Gene_expression denotes detectable
T4939 10440-10452 Protein denotes TLR4 protein
T4938 10278-10288 Gene_expression denotes expression
T4937 10237-10246 Positive_regulation denotes increased
T4936 10395-10399 Protein denotes TLR4
T4935 10292-10304 Protein denotes TLR4 protein
T4934 10247-10251 Protein denotes TLR4
T4933 10182-10191 Positive_regulation denotes Increased
T4932 10155-10165 Gene_expression denotes Expression
T4931 10169-10181 Protein denotes TLR4 Protein
T3741 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3740 8245-8255 Protein denotes anti-GAPDH
T3739 8072-8082 Protein denotes peroxidase
T2803 7297-7302 Positive_regulation denotes ratio
T2802 7253-7262 Positive_regulation denotes abundance
T2801 7319-7331 Protein denotes β-actin mRNA
T2800 7306-7315 Protein denotes TLR4 mRNA
T2799 7266-7275 Protein denotes TLR4 mRNA
T2798 6875-6882 Protein denotes β-actin
T2797 6777-6784 Protein denotes GenBank
T2796 6742-6749 Protein denotes β-actin
T2795 6733-6737 Protein denotes TLR4
T2794 6635-6642 Protein denotes β-actin
T2793 6594-6612 Protein denotes Taq DNA polymerase
T2792 6382-6402 Protein denotes RT-PCR (promega Inc)
T2791 5821-5830 Transcription denotes Detection
T2790 5834-5843 Protein denotes TLR4 mRNA
T923 3474-3478 Protein denotes TLR4
T922 3423-3427 Protein denotes TLR4
T921 3235-3248 Transcription denotes transcription
T920 3284-3288 Protein denotes TLR4
T919 3252-3261 Protein denotes TLR4 gene
T918 3168-3172 Protein denotes TLR4
T917 2944-2948 Protein denotes TLR4
T916 2567-2580 Localization denotes trans-locates
T915 2590-2597 Entity denotes nucleus
T914 2562-2566 Protein denotes NFκB
T913 2454-2461 Positive_regulation denotes induces
T912 2454-2461 Positive_regulation denotes induces
T911 2485-2494 Negative_regulation denotes inhibitor
T910 2485-2494 Negative_regulation denotes inhibitor
T909 2485-2494 Negative_regulation denotes inhibitor
T908 2485-2494 Negative_regulation denotes inhibitor
T907 2466-2481 Phosphorylation denotes phosphorylation
T906 2466-2481 Phosphorylation denotes phosphorylation
T905 2435-2445 Positive_regulation denotes activation
T904 2549-2553 Protein denotes NFκB
T903 2537-2547 Protein denotes NF-kappa-B
T902 2528-2531 Protein denotes IκB
T901 2507-2510 Protein denotes IκB
T900 2498-2505 Protein denotes kappa-B
T899 2449-2453 Protein denotes TLR4
T898 2157-2179 Protein denotes transmembrane proteins
T142 1256-1260 Protein denotes NFκB
T141 1242-1246 Protein denotes TLR4
T140 1139-1148 Positive_regulation denotes increased
T139 1129-1133 Protein denotes NFκB
T138 1102-1108 Protein denotes p-IκBα
T137 1004-1013 Negative_regulation denotes decreased
T136 921-930 Positive_regulation denotes increased
T135 885-894 Protein denotes TLR4 mRNA
T134 744-752 Positive_regulation denotes examined
T133 744-752 Positive_regulation denotes examined
T132 663-678 Phosphorylation denotes phosphorylation
T131 734-738 Protein denotes NFκB
T130 636-645 Protein denotes TLR4 mRNA
T129 523-533 Gene_expression denotes expression
T128 578-582 Protein denotes NFκB
T127 564-568 Protein denotes TLR4
T126 537-541 Protein denotes TLR4
T125 402-406 Protein denotes NFκB
T124 388-392 Protein denotes TLR4
T123 246-250 Protein denotes NFκB
T122 222-244 Protein denotes nuclear factor kappa-B
T5633 11262-11272 Positive_regulation denotes Activation
T5632 11281-11300 Protein denotes Mediated NF-Kappa-B
T5631 11276-11280 Protein denotes TLR4
T4031 9300-9304 Protein denotes NFκB
T4030 9271-9274 Protein denotes P50
T4029 9263-9266 Protein denotes P65
T4028 9044-9051 Binding denotes binding
T4027 9175-9221 Protein denotes double-stranded NFκB consensus oligonucleotide
T4026 9039-9043 Protein denotes NFκB
T5638 11416-11426 Protein denotes NF-kappa-B
T5637 11407-11410 Protein denotes IκB
T5636 11383-11386 Protein denotes IκB
T5635 11374-11381 Protein denotes kappa-B
T5634 11325-11329 Protein denotes TLR4
T5658 11780-11789 Positive_regulation denotes increased
T5657 11774-11779 Protein denotes p-IκB
T5656 11648-11657 Negative_regulation denotes inhibitor
T5655 11693-11697 Protein denotes NFκB
T5654 11609-11613 Protein denotes NFκB
T5653 11595-11599 Protein denotes TLR4
T5652 11441-11458 Protein denotes NFκB translocates
T5651 11330-11337 Positive_regulation denotes induces
T5650 11330-11337 Positive_regulation denotes induces
T5649 11395-11406 Positive_regulation denotes dissociates
T5648 11395-11406 Positive_regulation denotes dissociates
T5647 11395-11406 Positive_regulation denotes dissociates
T5646 11361-11370 Negative_regulation denotes inhibitor
T5645 11361-11370 Negative_regulation denotes inhibitor
T5644 11361-11370 Negative_regulation denotes inhibitor
T5643 11361-11370 Negative_regulation denotes inhibitor
T5642 11342-11357 Phosphorylation denotes phosphorylation
T5641 11342-11357 Phosphorylation denotes phosphorylation
T5640 11311-11321 Positive_regulation denotes Activation
T5639 11428-11432 Protein denotes NFκB
T3538 7566-7576 Protein denotes peroxidase
T3537 7559-7565 Protein denotes avidin
T3536 7387-7391 Protein denotes TLR4
T2253 4836-4843 Positive_regulation denotes induced
T2252 4828-4831 Protein denotes ICH
T1775 4431-4439 Protein denotes paraffin
R21 T132 T134 themeOf phosphorylation,examined
R17 T120 T121 themeOf NFκB,Activation
R18 T126 T129 themeOf TLR4,expression
R19 T130 T132 themeOf TLR4 mRNA,phosphorylation
R20 T130 T133 themeOf TLR4 mRNA,examined
R549 T900 T906 themeOf kappa-B,phosphorylation
R550 T900 T908 themeOf kappa-B,inhibitor
R551 T901 T907 themeOf IκB,phosphorylation
R552 T901 T909 themeOf IκB,inhibitor
R553 T905 T912 causeOf activation,induces
R554 T905 T913 causeOf activation,induces
R555 T906 T910 themeOf phosphorylation,inhibitor
R556 T906 T912 themeOf phosphorylation,induces
R557 T907 T911 themeOf phosphorylation,inhibitor
R558 T907 T913 themeOf phosphorylation,induces
R559 T914 T916 themeOf NFκB,trans-locates
R560 T915 T916 locationOf nucleus,trans-locates
R561 T919 T921 themeOf TLR4 gene,transcription
R2184 T2790 T2791 themeOf TLR4 mRNA,Detection
R2185 T2799 T2802 themeOf TLR4 mRNA,abundance
R2186 T2800 T2803 themeOf TLR4 mRNA,ratio
R2187 T2801 T2803 causeOf β-actin mRNA,ratio
R3108 T4026 T4028 themeOf NFκB,binding
R3510 T4524 T4525 themeOf TLR4 mRNA,Increased
R3511 T4528 T4529 themeOf TLR4 mRNA,increased
R3512 T4530 T4531 themeOf TLR4 mRNA,increased
R3513 T4530 T4532 themeOf TLR4 mRNA,decreased
R3793 T4931 T4932 themeOf TLR4 Protein,Expression
R3794 T4932 T4933 themeOf Expression,Increased
R3795 T4934 T4937 themeOf TLR4,increased
R3796 T4935 T4938 themeOf TLR4 protein,expression
R3797 T4939 T4940 themeOf TLR4 protein,detectable
R3798 T4941 T4942 themeOf TLR4,expression
R3799 T4942 T4943 themeOf expression,increased
R3800 T4942 T4944 themeOf expression,decreased
R3801 T4945 T4948 themeOf TLR4 protein,observation
R3802 T4946 T4949 themeOf TLR4 mRNA,profile
R3803 T4947 T4949 causeOf ICH,profile
R4107 T5381 T5383 themeOf TLR4 protein,distribution
R4260 T5632 T5633 themeOf Mediated NF-Kappa-B,Activation
R4261 T5634 T5640 themeOf TLR4,Activation
R4262 T5635 T5641 themeOf kappa-B,phosphorylation
R4263 T5635 T5643 themeOf kappa-B,inhibitor
R4264 T5636 T5642 themeOf IκB,phosphorylation
R4265 T5636 T5644 themeOf IκB,inhibitor
R4266 T5637 T5647 themeOf IκB,dissociates
R4267 T5638 T5647 causeOf NF-kappa-B,dissociates
R4268 T5638 T5648 causeOf NF-kappa-B,dissociates
R4269 T5638 T5649 causeOf NF-kappa-B,dissociates
R4270 T5640 T5650 causeOf Activation,induces
R4271 T5640 T5651 causeOf Activation,induces
R4272 T5641 T5645 themeOf phosphorylation,inhibitor
R4273 T5641 T5648 themeOf phosphorylation,dissociates
R4274 T5641 T5650 themeOf phosphorylation,induces
R4275 T5642 T5646 themeOf phosphorylation,inhibitor
R4276 T5642 T5649 themeOf phosphorylation,dissociates
R4277 T5642 T5651 themeOf phosphorylation,induces
R4278 T5655 T5656 themeOf NFκB,inhibitor
R4279 T5657 T5658 themeOf p-IκB,increased
R4280 T5659 T5661 themeOf NFκB,increased
R4675 T6408 T6409 themeOf NFκB,transcription
R4676 T6411 T6413 themeOf NFκB,activation
R4677 T6414 T6415 themeOf NFκB,Activation
R4678 T6416 T6417 themeOf NFκB,Inhibition
R4679 T6418 T6419 themeOf NFκB,activated
R4680 T6422 T6427 themeOf NFκB,activation
R4681 T6428 T6429 themeOf TLR4 mRNA,detected
R4682 T6430 T6432 themeOf TLR4,transcription
R4683 T6431 T6433 themeOf TLR4,expression
R4684 T6432 T6434 themeOf transcription,elevated
R4685 T6433 T6435 themeOf expression,elevated
R4686 T6436 T6437 themeOf TLR4 protein,distributed
R4687 T6438 T6439 themeOf TLR4,expression
R4688 T6439 T6440 themeOf expression,increased
R4689 T6445 T6447 themeOf p-IκB,detecting
R4690 T6446 T6448 themeOf NFκB,detecting
R4691 T6451 T6454 themeOf TLR4,Activation
R4692 T6452 T6455 themeOf IκBα,phosphorylation
R4693 T6452 T6456 themeOf IκBα,degradation
R4694 T6453 T6458 themeOf NFκB,translocation
R4695 T6454 T6459 causeOf Activation,stimulates
R4696 T6454 T6460 causeOf Activation,stimulates
R4697 T6455 T6459 themeOf phosphorylation,stimulates
R4698 T6456 T6460 themeOf degradation,stimulates
R4699 T6457 T6458 locationOf nuclear,translocation
R4700 T6461 T6463 themeOf IκB,phosphorylation
R4701 T6463 T6464 themeOf phosphorylation,increased
R4702 T6465 T6468 themeOf p-IκB,expression
R4703 T6466 T6469 themeOf NFκB,activation
R4704 T6467 T6471 themeOf TLR4,expression
R4705 T6468 T6470 themeOf expression,activation
R4706 T6472 T6481 causeOf ICH,stimulates
R4707 T6472 T6482 causeOf ICH,stimulates
R4708 T6473 T6477 themeOf TLR4,activation
R4709 T6474 T6478 themeOf NFκB,activation
R4710 T6475 T6479 themeOf NFκB,activation
R4711 T6477 T6481 themeOf activation,stimulates
R4712 T6478 T6482 themeOf activation,stimulates
R4713 T6479 T6480 themeOf activation,regulated
R4714 T6483 T6484 themeOf TLR4,recognize
R4715 T6485 T6488 themeOf HSP70,upregulated
R4716 T6486 T6489 themeOf HSP32,upregulated
R4717 T6487 T6490 themeOf HSP27,upregulated
R22 T135 T136 themeOf TLR4 mRNA,increased
R23 T135 T137 themeOf TLR4 mRNA,decreased
R24 T138 T140 themeOf p-IκBα,increased
R548 T899 T905 themeOf TLR4,activation
R1762 T2252 T2253 themeOf ICH,induced
R4106 T5379 T5380 themeOf TLR4,Distribution

testone

Id Subject Object Predicate Lexical cue
T13 14-18 Protein denotes TLR4
T6097 17495-17503 Gene_expression denotes produced
T6096 16986-16995 Regulation denotes regulated
T6095 16813-16823 Gene_expression denotes expression
T6094 16739-16749 Gene_expression denotes expression
T6093 16674-16683 Positive_regulation denotes increased
T6092 16449-16462 Localization denotes translocation
T6091 16415-16426 Protein_catabolism denotes degradation
T6090 16395-16410 Phosphorylation denotes phosphorylation
T6089 16360-16370 Positive_regulation denotes Activation
T6088 15633-15643 Gene_expression denotes expression
T6087 15623-15632 Positive_regulation denotes increased
T6086 15276-15284 Positive_regulation denotes elevated
T6085 15225-15235 Gene_expression denotes expression
T6084 15188-15201 Transcription denotes transcription
T6083 14553-14563 Binding denotes recognized
T6082 14133-14141 Gene_expression denotes produced
T6081 12859-12868 Gene_expression denotes producing
T6080 18136-18140 Protein denotes TLR4
T6079 18035-18039 Protein denotes TLR4
T6078 17844-17848 Protein denotes TLR4
T6077 17715-17719 Protein denotes TLR4
T6076 17692-17696 Protein denotes TLR4
T6075 17382-17387 Protein denotes HSP27
T6074 17375-17380 Protein denotes HSP32
T6073 17368-17373 Protein denotes HSP70
T6072 17041-17045 Protein denotes TLR4
T6071 17008-17012 Protein denotes TLR4
T6070 16888-16892 Protein denotes TLR4
T6069 16827-16831 Protein denotes TLR4
T6068 16390-16394 Protein denotes IκBα
T6067 16374-16378 Protein denotes TLR4
T6066 16327-16331 Protein denotes TLR4
T6065 16167-16171 Protein denotes TLR4
T6064 15919-15923 Protein denotes TLR4
T6063 15647-15651 Protein denotes TLR4
T6062 15422-15426 Protein denotes TLR4
T6061 15239-15243 Protein denotes TLR4
T6060 15205-15209 Protein denotes TLR4
T6059 15144-15148 Protein denotes TLR4
T6058 15018-15022 Protein denotes TLR4
T6057 14523-14527 Protein denotes TLR4
T5598 11962-11971 Positive_regulation denotes increased
T5597 11780-11789 Positive_regulation denotes increased
T5596 11468-11475 Entity denotes nucleus
T5595 11311-11321 Positive_regulation denotes Activation
T5594 11595-11599 Protein denotes TLR4
T5593 11325-11329 Protein denotes TLR4
T5592 11276-11280 Protein denotes TLR4
T5346 11112-11116 Protein denotes TLR4
T5345 10995-10999 Protein denotes TLR4
T5344 10926-10930 Protein denotes TLR4
T5343 10908-10912 Protein denotes TLR4
T5342 10846-10850 Protein denotes TLR4
T4871 10629-10638 Negative_regulation denotes decreased
T4870 10534-10543 Positive_regulation denotes increased
T4869 10501-10511 Gene_expression denotes expression
T4868 10278-10288 Gene_expression denotes expression
T4867 10237-10246 Positive_regulation denotes increased
T4866 10182-10191 Positive_regulation denotes Increased
T4865 10155-10165 Gene_expression denotes Expression
T4864 10803-10807 Protein denotes TLR4
T4863 10742-10746 Protein denotes TLR4
T4862 10515-10519 Protein denotes TLR4
T4861 10440-10444 Protein denotes TLR4
T4860 10395-10399 Protein denotes TLR4
T4859 10292-10296 Protein denotes TLR4
T4858 10247-10251 Protein denotes TLR4
T4857 10169-10173 Protein denotes TLR4
T4487 10017-10026 Negative_regulation denotes decreased
T4486 9922-9931 Positive_regulation denotes increased
T4485 9809-9818 Positive_regulation denotes increased
T4484 9611-9620 Positive_regulation denotes Increased
T4483 9888-9892 Protein denotes TLR4
T4482 9790-9794 Protein denotes TLR4
T4481 9706-9710 Protein denotes TLR4
T4480 9647-9651 Protein denotes TLR4
T4479 9601-9605 Protein denotes TLR4
T3995 9305-9312 Binding denotes binding
T3994 9271-9274 Protein denotes P50
T3993 9263-9266 Protein denotes P65
T3710 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3709 8250-8255 Protein denotes GAPDH
T3507 7559-7565 Protein denotes avidin
T3506 7387-7391 Protein denotes TLR4
T2229 4836-4843 Positive_regulation denotes induced
T2703 7280-7289 Gene_expression denotes expressed
T2702 7319-7326 Protein denotes β-actin
T2701 7306-7310 Protein denotes TLR4
T2700 7266-7270 Protein denotes TLR4
T2699 6875-6882 Protein denotes β-actin
T2698 6786-6790 Protein denotes TLR4
T2697 6742-6749 Protein denotes β-actin
T2696 6733-6737 Protein denotes TLR4
T2695 6635-6642 Protein denotes β-actin
T2694 6614-6633 Protein denotes The house keep gene
T2693 6594-6612 Protein denotes Taq DNA polymerase
T2692 6494-6498 Protein denotes TLR4
T2691 5834-5838 Protein denotes TLR4
T804 3235-3248 Transcription denotes transcription
T803 2435-2445 Positive_regulation denotes activation
T802 3474-3478 Protein denotes TLR4
T801 3423-3427 Protein denotes TLR4
T800 3284-3288 Protein denotes TLR4
T799 3252-3256 Protein denotes TLR4
T798 3168-3172 Protein denotes TLR4
T797 2944-2948 Protein denotes TLR4
T796 2449-2453 Protein denotes TLR4
T28 1139-1148 Positive_regulation denotes increased
T27 1004-1013 Negative_regulation denotes decreased
T26 921-930 Positive_regulation denotes increased
T25 523-533 Gene_expression denotes expression
T24 1242-1246 Protein denotes TLR4
T23 1104-1108 Protein denotes IκBα
T22 885-889 Protein denotes TLR4
T21 707-711 Protein denotes IκBα
T20 682-703 Protein denotes inhibitors of kappa B
T19 636-640 Protein denotes TLR4
T18 564-568 Protein denotes TLR4
T17 537-541 Protein denotes TLR4
T16 388-392 Protein denotes TLR4
T15 206-210 Protein denotes TLR4
T14 183-203 Protein denotes Toll-like receptor 4
R542 T796 T803 themeOf TLR4,activation
R543 T799 T804 themeOf TLR4,transcription
R2180 T2695 T2694 equivalentTo β-actin,The house keep gene
R2181 T2701 T2703 themeOf TLR4,expressed
R2886 T3710 T3709 equivalentTo glyceraldehyde-3-phosphate dehydrogenase,GAPDH
R3104 T3993 T3995 themeOf P65,binding
R3105 T3994 T3995 themeOf P50,binding
R3770 T4857 T4865 themeOf TLR4,Expression
R3771 T4858 T4867 themeOf TLR4,increased
R3772 T4859 T4868 themeOf TLR4,expression
R3773 T4862 T4869 themeOf TLR4,expression
R3774 T4865 T4866 themeOf Expression,Increased
R3775 T4868 T4867 themeOf expression,increased
R3776 T4869 T4870 themeOf expression,increased
R3777 T4869 T4871 themeOf expression,decreased
R4258 T5593 T5595 themeOf TLR4,Activation
R4608 T6057 T6083 themeOf TLR4,recognized
R4609 T6060 T6084 themeOf TLR4,transcription
R4610 T6061 T6085 themeOf TLR4,expression
R4611 T6063 T6088 themeOf TLR4,expression
R4612 T6067 T6089 themeOf TLR4,Activation
R4613 T6067 T6091 themeOf TLR4,degradation
R4614 T6067 T6092 themeOf TLR4,translocation
R4615 T6068 T6092 themeOf IκBα,translocation
R4616 T6068 T6091 themeOf IκBα,degradation
R4617 T6068 T6090 themeOf IκBα,phosphorylation
R4618 T6069 T6095 themeOf TLR4,expression
R4619 T6073 T6097 themeOf HSP70,produced
R4620 T6074 T6097 themeOf HSP32,produced
R4621 T6075 T6097 themeOf HSP27,produced
R4622 T6085 T6086 themeOf expression,elevated
R4623 T6088 T6087 themeOf expression,increased
R1 T15 T14 equivalentTo TLR4,Toll-like receptor 4
R2 T17 T25 themeOf TLR4,expression
R3 T21 T20 equivalentTo IκBα,inhibitors of kappa B

test3

Id Subject Object Predicate Lexical cue
T29 14-18 Protein denotes TLR4
T41 14-18 Protein denotes TLR4
T4000 9305-9312 Binding denotes binding
T6159 18136-18140 Protein denotes TLR4
T6158 18035-18039 Protein denotes TLR4
T6157 17844-17848 Protein denotes TLR4
T6156 17715-17719 Protein denotes TLR4
T6155 17692-17696 Protein denotes TLR4
T6154 17495-17503 Gene_expression denotes produced
T6153 17382-17387 Protein denotes HSP27
T6152 17375-17380 Protein denotes HSP32
T6151 17368-17373 Protein denotes HSP70
T6150 17041-17045 Protein denotes TLR4
T6149 17008-17012 Protein denotes TLR4
T6148 16888-16892 Protein denotes TLR4
T6147 16827-16831 Protein denotes TLR4
T6146 16813-16823 Gene_expression denotes expression
T6145 16607-16622 Phosphorylation denotes phosphorylation
T6144 16449-16462 Localization denotes translocation
T6143 16441-16448 Entity denotes nuclear
T6142 16428-16437 Positive_regulation denotes resulting
T6141 16415-16426 Protein_catabolism denotes degradation
T6140 16395-16410 Phosphorylation denotes phosphorylation
T6139 16390-16394 Protein denotes IκBα
T6138 16374-16378 Protein denotes TLR4
T6137 16360-16370 Positive_regulation denotes Activation
T6136 16327-16331 Protein denotes TLR4
T6135 16167-16171 Protein denotes TLR4
T6134 15919-15923 Protein denotes TLR4
T6133 15647-15651 Protein denotes TLR4
T6132 15633-15643 Gene_expression denotes expression
T6131 15623-15632 Positive_regulation denotes increased
T6130 15422-15426 Protein denotes TLR4
T6129 15239-15243 Protein denotes TLR4
T6128 15225-15235 Gene_expression denotes expression
T6127 15205-15209 Protein denotes TLR4
T6126 15188-15201 Transcription denotes transcription
T6125 15144-15148 Protein denotes TLR4
T6124 15131-15139 Gene_expression denotes detected
T6123 15018-15022 Protein denotes TLR4
T6122 14523-14527 Protein denotes TLR4
T6121 18136-18140 Protein denotes TLR4
T6120 18035-18039 Protein denotes TLR4
T6119 17844-17848 Protein denotes TLR4
T6118 17715-17719 Protein denotes TLR4
T6117 17692-17696 Protein denotes TLR4
T6116 17382-17387 Protein denotes HSP27
T6115 17375-17380 Protein denotes HSP32
T6114 17368-17373 Protein denotes HSP70
T6113 17041-17045 Protein denotes TLR4
T6112 17008-17012 Protein denotes TLR4
T6111 16888-16892 Protein denotes TLR4
T6110 16827-16831 Protein denotes TLR4
T6109 16390-16394 Protein denotes IκBα
T6108 16374-16378 Protein denotes TLR4
T6107 16327-16331 Protein denotes TLR4
T6106 16167-16171 Protein denotes TLR4
T6105 15919-15923 Protein denotes TLR4
T6104 15647-15651 Protein denotes TLR4
T6103 15422-15426 Protein denotes TLR4
T6102 15239-15243 Protein denotes TLR4
T6101 15205-15209 Protein denotes TLR4
T6100 15144-15148 Protein denotes TLR4
T6099 15018-15022 Protein denotes TLR4
T6098 14523-14527 Protein denotes TLR4
T5606 11780-11789 Positive_regulation denotes increased
T5605 11595-11599 Protein denotes TLR4
T5604 11330-11337 Positive_regulation denotes induces
T5603 11325-11329 Protein denotes TLR4
T5602 11276-11280 Protein denotes TLR4
T5601 11595-11599 Protein denotes TLR4
T5600 11325-11329 Protein denotes TLR4
T5599 11276-11280 Protein denotes TLR4
T5356 11112-11116 Protein denotes TLR4
T5355 10995-10999 Protein denotes TLR4
T5354 10926-10930 Protein denotes TLR4
T5353 10908-10912 Protein denotes TLR4
T5352 10846-10850 Protein denotes TLR4
T5351 11112-11116 Protein denotes TLR4
T5350 10995-10999 Protein denotes TLR4
T5349 10926-10930 Protein denotes TLR4
T5348 10908-10912 Protein denotes TLR4
T5347 10846-10850 Protein denotes TLR4
T4894 10803-10807 Protein denotes TLR4
T4893 10788-10795 Binding denotes profile
T4892 10742-10746 Protein denotes TLR4
T4891 10534-10543 Positive_regulation denotes increased
T4890 10515-10519 Protein denotes TLR4
T4889 10501-10511 Gene_expression denotes expression
T4888 10440-10444 Protein denotes TLR4
T4887 10395-10399 Protein denotes TLR4
T4886 10292-10296 Protein denotes TLR4
T4885 10278-10288 Gene_expression denotes expression
T4884 10247-10251 Protein denotes TLR4
T4883 10237-10246 Positive_regulation denotes increased
T4882 10182-10191 Positive_regulation denotes Increased
T4881 10169-10173 Protein denotes TLR4
T4880 10155-10165 Gene_expression denotes Expression
T4879 10803-10807 Protein denotes TLR4
T4878 10742-10746 Protein denotes TLR4
T4877 10515-10519 Protein denotes TLR4
T4876 10440-10444 Protein denotes TLR4
T4875 10395-10399 Protein denotes TLR4
T4874 10292-10296 Protein denotes TLR4
T4873 10247-10251 Protein denotes TLR4
T4872 10169-10173 Protein denotes TLR4
T4500 10017-10026 Negative_regulation denotes decreased
T4499 9922-9931 Positive_regulation denotes increased
T4498 9888-9892 Protein denotes TLR4
T4497 9809-9818 Positive_regulation denotes increased
T4496 9790-9794 Protein denotes TLR4
T4495 9706-9710 Protein denotes TLR4
T4494 9647-9651 Protein denotes TLR4
T4493 9601-9605 Protein denotes TLR4
T4492 9888-9892 Protein denotes TLR4
T4491 9790-9794 Protein denotes TLR4
T4490 9706-9710 Protein denotes TLR4
T4489 9647-9651 Protein denotes TLR4
T4488 9601-9605 Protein denotes TLR4
T3999 9271-9274 Protein denotes P50
T3998 9263-9266 Protein denotes P65
T3997 9271-9274 Protein denotes P50
T3996 9263-9266 Protein denotes P65
T3714 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3713 8250-8255 Protein denotes GAPDH
T3712 8257-8297 Protein denotes glyceraldehyde-3-phosphate dehydrogenase
T3711 8250-8255 Protein denotes GAPDH
T3511 7559-7565 Protein denotes avidin
T3510 7387-7391 Protein denotes TLR4
T3509 7559-7565 Protein denotes avidin
T3508 7387-7391 Protein denotes TLR4
T2230 4836-4843 Positive_regulation denotes induced
T2728 7319-7326 Protein denotes β-actin
T2727 7306-7310 Protein denotes TLR4
T2725 7266-7270 Protein denotes TLR4
T2724 6875-6882 Protein denotes β-actin
T2723 6786-6790 Protein denotes TLR4
T2722 6742-6749 Protein denotes β-actin
T2721 6733-6737 Protein denotes TLR4
T2720 6635-6642 Protein denotes β-actin
T2719 6614-6633 Protein denotes The house keep gene
T2718 6594-6612 Protein denotes Taq DNA polymerase
T2717 6494-6498 Protein denotes TLR4
T2716 5834-5838 Protein denotes TLR4
T2715 7319-7326 Protein denotes β-actin
T2714 7306-7310 Protein denotes TLR4
T2713 7266-7270 Protein denotes TLR4
T2712 6875-6882 Protein denotes β-actin
T2711 6786-6790 Protein denotes TLR4
T2710 6742-6749 Protein denotes β-actin
T2709 6733-6737 Protein denotes TLR4
T2708 6635-6642 Protein denotes β-actin
T2707 6614-6633 Protein denotes The house keep gene
T2706 6594-6612 Protein denotes Taq DNA polymerase
T2705 6494-6498 Protein denotes TLR4
T2704 5834-5838 Protein denotes TLR4
T2726 7280-7289 Transcription denotes expressed
T821 3474-3478 Protein denotes TLR4
T820 3423-3427 Protein denotes TLR4
T819 3284-3288 Protein denotes TLR4
T818 3252-3256 Protein denotes TLR4
T817 3235-3248 Transcription denotes transcription
T816 3168-3172 Protein denotes TLR4
T815 2944-2948 Protein denotes TLR4
T814 2454-2461 Positive_regulation denotes induces
T813 2449-2453 Protein denotes TLR4
T812 1805-1812 Positive_regulation denotes induced
T811 3474-3478 Protein denotes TLR4
T810 3423-3427 Protein denotes TLR4
T809 3284-3288 Protein denotes TLR4
T808 3252-3256 Protein denotes TLR4
T807 3168-3172 Protein denotes TLR4
T806 2944-2948 Protein denotes TLR4
T805 2449-2453 Protein denotes TLR4
T40 1242-1246 Protein denotes TLR4
T39 1104-1108 Protein denotes IκBα
T38 885-889 Protein denotes TLR4
T37 707-711 Protein denotes IκBα
T36 682-703 Protein denotes inhibitors of kappa B
T35 636-640 Protein denotes TLR4
T34 564-568 Protein denotes TLR4
T33 537-541 Protein denotes TLR4
T32 388-392 Protein denotes TLR4
T31 206-210 Protein denotes TLR4
T30 183-203 Protein denotes Toll-like receptor 4
T55 1242-1246 Protein denotes TLR4
T54 1104-1108 Protein denotes IκBα
T53 1004-1013 Negative_regulation denotes decreased
T52 921-930 Positive_regulation denotes increased
T51 885-889 Protein denotes TLR4
T50 707-711 Protein denotes IκBα
T49 682-703 Protein denotes inhibitors of kappa B
T48 636-640 Protein denotes TLR4
T47 564-568 Protein denotes TLR4
T46 537-541 Protein denotes TLR4
T45 523-533 Gene_expression denotes expression
T44 388-392 Protein denotes TLR4
T43 206-210 Protein denotes TLR4
T42 183-203 Protein denotes Toll-like receptor 4
R4 T43 T42 equivalentTo TLR4,Toll-like receptor 4
R5 T46 T45 themeOf TLR4,expression
R6 T50 T49 equivalentTo IκBα,inhibitors of kappa B
R7 T51 T52 themeOf TLR4,increased
R8 T51 T53 themeOf TLR4,decreased
R544 T818 T817 themeOf TLR4,transcription
R2182 T2720 T2719 equivalentTo β-actin,The house keep gene
R2887 T3714 T3713 equivalentTo glyceraldehyde-3-phosphate dehydrogenase,GAPDH
R3106 T3998 T4000 themeOf P65,binding
R3107 T3999 T4000 themeOf P50,binding
R3504 T4496 T4497 themeOf TLR4,increased
R3505 T4498 T4499 themeOf TLR4,increased
R3506 T4498 T4500 themeOf TLR4,decreased
R3778 T4880 T4882 themeOf Expression,Increased
R3779 T4881 T4880 themeOf TLR4,Expression
R3780 T4884 T4883 themeOf TLR4,increased
R3781 T4885 T4883 themeOf expression,increased
R3782 T4886 T4885 themeOf TLR4,expression
R3783 T4889 T4891 themeOf expression,increased
R3784 T4890 T4889 themeOf TLR4,expression
R3785 T4894 T4893 themeOf TLR4,profile
R4624 T6125 T6124 themeOf TLR4,detected
R4625 T6127 T6126 themeOf TLR4,transcription
R4626 T6129 T6128 themeOf TLR4,expression
R4627 T6132 T6131 themeOf expression,increased
R4628 T6133 T6132 themeOf TLR4,expression
R4629 T6137 T6142 causeOf Activation,resulting
R4630 T6138 T6144 themeOf TLR4,translocation
R4631 T6139 T6144 themeOf IκBα,translocation
R4632 T6139 T6141 themeOf IκBα,degradation
R4633 T6139 T6140 themeOf IκBα,phosphorylation
R4634 T6140 T6137 themeOf phosphorylation,Activation
R4635 T6143 T6144 locationOf nuclear,translocation
R4636 T6144 T6142 themeOf translocation,resulting
R4637 T6147 T6146 themeOf TLR4,expression
R4638 T6151 T6154 themeOf HSP70,produced
R4639 T6152 T6154 themeOf HSP32,produced
R4640 T6153 T6154 themeOf HSP27,produced