| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1425 |
0-9 |
JJ |
denotes |
Mammalian |
| T1426 |
10-17 |
NNS |
denotes |
enzymes |
| T1427 |
50-54 |
VBP |
denotes |
form |
| T1428 |
18-28 |
JJ |
denotes |
homologous |
| T1429 |
29-31 |
IN |
denotes |
to |
| T1430 |
32-37 |
JJ |
denotes |
human |
| T1431 |
38-42 |
NN |
denotes |
CLN2 |
| T1432 |
43-44 |
-LRB- |
denotes |
[ |
| T1433 |
47-48 |
CD |
denotes |
4 |
| T1434 |
44-45 |
CD |
denotes |
2 |
| T1435 |
45-46 |
, |
denotes |
, |
| T1436 |
48-49 |
-RRB- |
denotes |
] |
| T1437 |
55-56 |
DT |
denotes |
a |
| T1438 |
57-66 |
NN |
denotes |
subfamily |
| T1439 |
67-69 |
IN |
denotes |
of |
| T1440 |
70-80 |
NNS |
denotes |
sedolisins |
| T1441 |
81-85 |
IN |
denotes |
with |
| T1442 |
86-92 |
RB |
denotes |
highly |
| T1443 |
93-102 |
VBN |
denotes |
conserved |
| T1444 |
103-112 |
NNS |
denotes |
sequences |
| T1445 |
113-114 |
-LRB- |
denotes |
( |
| T1446 |
114-120 |
NN |
denotes |
Figure |
| T1447 |
121-122 |
CD |
denotes |
1 |
| T1448 |
122-123 |
-RRB- |
denotes |
) |
| T1449 |
123-124 |
. |
denotes |
. |
| T1450 |
124-274 |
sentence |
denotes |
These enzymes are expressed with a prosegment consisting of 195 residues that is cleaved off during maturation, yielding the active catalytic domain. |
| T1451 |
125-130 |
DT |
denotes |
These |
| T1452 |
131-138 |
NNS |
denotes |
enzymes |
| T1453 |
143-152 |
VBN |
denotes |
expressed |
| T1454 |
139-142 |
VBP |
denotes |
are |
| T1455 |
153-157 |
IN |
denotes |
with |
| T1456 |
158-159 |
DT |
denotes |
a |
| T1457 |
160-170 |
NN |
denotes |
prosegment |
| T1458 |
171-181 |
VBG |
denotes |
consisting |
| T1459 |
182-184 |
IN |
denotes |
of |
| T1460 |
185-188 |
CD |
denotes |
195 |
| T1461 |
189-197 |
NNS |
denotes |
residues |
| T1462 |
198-202 |
WDT |
denotes |
that |
| T1463 |
206-213 |
VBN |
denotes |
cleaved |
| T1464 |
203-205 |
VBZ |
denotes |
is |
| T1465 |
214-217 |
RP |
denotes |
off |
| T1466 |
218-224 |
IN |
denotes |
during |
| T1467 |
225-235 |
NN |
denotes |
maturation |
| T1468 |
235-237 |
, |
denotes |
, |
| T1469 |
237-245 |
VBG |
denotes |
yielding |
| T1470 |
246-249 |
DT |
denotes |
the |
| T1471 |
267-273 |
NN |
denotes |
domain |
| T1472 |
250-256 |
JJ |
denotes |
active |
| T1473 |
257-266 |
JJ |
denotes |
catalytic |
| T1474 |
273-274 |
. |
denotes |
. |
| T1475 |
274-411 |
sentence |
denotes |
Complete sequences are available for CLN2 from six species in which it has been found so far (human, macaque, dog, mouse, rat, and cow). |
| T1476 |
275-283 |
JJ |
denotes |
Complete |
| T1477 |
284-293 |
NNS |
denotes |
sequences |
| T1478 |
294-297 |
VBP |
denotes |
are |
| T1479 |
298-307 |
JJ |
denotes |
available |
| T1480 |
308-311 |
IN |
denotes |
for |
| T1481 |
312-316 |
NN |
denotes |
CLN2 |
| T1482 |
317-321 |
IN |
denotes |
from |
| T1483 |
322-325 |
CD |
denotes |
six |
| T1484 |
326-333 |
NNS |
denotes |
species |
| T1485 |
334-336 |
IN |
denotes |
in |
| T1486 |
355-360 |
VBN |
denotes |
found |
| T1487 |
337-342 |
WDT |
denotes |
which |
| T1488 |
343-345 |
PRP |
denotes |
it |
| T1489 |
346-349 |
VBZ |
denotes |
has |
| T1490 |
350-354 |
VBN |
denotes |
been |
| T1491 |
361-363 |
RB |
denotes |
so |
| T1492 |
364-367 |
RB |
denotes |
far |
| T1493 |
368-369 |
-LRB- |
denotes |
( |
| T1494 |
369-374 |
JJ |
denotes |
human |
| T1495 |
376-383 |
NN |
denotes |
macaque |
| T1496 |
374-376 |
, |
denotes |
, |
| T1497 |
383-385 |
, |
denotes |
, |
| T1498 |
385-388 |
NN |
denotes |
dog |
| T1499 |
388-390 |
, |
denotes |
, |
| T1500 |
390-395 |
NN |
denotes |
mouse |
| T1501 |
395-397 |
, |
denotes |
, |
| T1502 |
397-400 |
NN |
denotes |
rat |
| T1503 |
400-402 |
, |
denotes |
, |
| T1504 |
402-405 |
CC |
denotes |
and |
| T1505 |
406-409 |
NN |
denotes |
cow |
| T1506 |
409-410 |
-RRB- |
denotes |
) |
| T1507 |
410-411 |
. |
denotes |
. |
| T1508 |
411-637 |
sentence |
denotes |
The full-length enzymes consist of 563 amino acids arranged in a single polypeptide chain containing both the prosegment and the catalytic domain, with the exception of mouse CLN2 that has a single deletion in the prosegment. |
| T1509 |
412-415 |
DT |
denotes |
The |
| T1510 |
428-435 |
NNS |
denotes |
enzymes |
| T1511 |
416-420 |
JJ |
denotes |
full |
| T1512 |
421-427 |
NN |
denotes |
length |
| T1513 |
420-421 |
HYPH |
denotes |
- |
| T1514 |
436-443 |
VBP |
denotes |
consist |
| T1515 |
444-446 |
IN |
denotes |
of |
| T1516 |
447-450 |
CD |
denotes |
563 |
| T1517 |
457-462 |
NNS |
denotes |
acids |
| T1518 |
451-456 |
NN |
denotes |
amino |
| T1519 |
463-471 |
VBN |
denotes |
arranged |
| T1520 |
472-474 |
IN |
denotes |
in |
| T1521 |
475-476 |
DT |
denotes |
a |
| T1522 |
496-501 |
NN |
denotes |
chain |
| T1523 |
477-483 |
JJ |
denotes |
single |
| T1524 |
484-495 |
NN |
denotes |
polypeptide |
| T1525 |
502-512 |
VBG |
denotes |
containing |
| T1526 |
513-517 |
CC |
denotes |
both |
| T1527 |
522-532 |
NN |
denotes |
prosegment |
| T1528 |
518-521 |
DT |
denotes |
the |
| T1529 |
533-536 |
CC |
denotes |
and |
| T1530 |
537-540 |
DT |
denotes |
the |
| T1531 |
541-550 |
JJ |
denotes |
catalytic |
| T1532 |
551-557 |
NN |
denotes |
domain |
| T1533 |
557-559 |
, |
denotes |
, |
| T1534 |
559-563 |
IN |
denotes |
with |
| T1535 |
564-567 |
DT |
denotes |
the |
| T1536 |
568-577 |
NN |
denotes |
exception |
| T1537 |
578-580 |
IN |
denotes |
of |
| T1538 |
581-586 |
NN |
denotes |
mouse |
| T1539 |
587-591 |
NN |
denotes |
CLN2 |
| T1540 |
592-596 |
WDT |
denotes |
that |
| T1541 |
597-600 |
VBZ |
denotes |
has |
| T1542 |
601-602 |
DT |
denotes |
a |
| T1543 |
610-618 |
NN |
denotes |
deletion |
| T1544 |
603-609 |
JJ |
denotes |
single |
| T1545 |
619-621 |
IN |
denotes |
in |
| T1546 |
622-625 |
DT |
denotes |
the |
| T1547 |
626-636 |
NN |
denotes |
prosegment |
| T1548 |
636-637 |
. |
denotes |
. |
| T1549 |
637-724 |
sentence |
denotes |
The overall sequence identity for these enzymes is 81%, whereas the similarity is 92%. |
| T1550 |
638-641 |
DT |
denotes |
The |
| T1551 |
659-667 |
NN |
denotes |
identity |
| T1552 |
642-649 |
JJ |
denotes |
overall |
| T1553 |
650-658 |
NN |
denotes |
sequence |
| T1554 |
686-688 |
VBZ |
denotes |
is |
| T1555 |
668-671 |
IN |
denotes |
for |
| T1556 |
672-677 |
DT |
denotes |
these |
| T1557 |
678-685 |
NNS |
denotes |
enzymes |
| T1558 |
689-691 |
CD |
denotes |
81 |
| T1559 |
691-692 |
NN |
denotes |
% |
| T1560 |
692-694 |
, |
denotes |
, |
| T1561 |
694-701 |
IN |
denotes |
whereas |
| T1562 |
717-719 |
VBZ |
denotes |
is |
| T1563 |
702-705 |
DT |
denotes |
the |
| T1564 |
706-716 |
NN |
denotes |
similarity |
| T1565 |
720-722 |
CD |
denotes |
92 |
| T1566 |
722-723 |
NN |
denotes |
% |
| T1567 |
723-724 |
. |
denotes |
. |
| T1568 |
724-924 |
sentence |
denotes |
A pairwise comparison of the human and mouse enzymes yields 88% identity and 94% similarity, considerably higher than the median 78.5% identity reported for all identified mouse-human orthologs [13]. |
| T1569 |
725-726 |
DT |
denotes |
A |
| T1570 |
736-746 |
NN |
denotes |
comparison |
| T1571 |
727-735 |
JJ |
denotes |
pairwise |
| T1572 |
778-784 |
VBZ |
denotes |
yields |
| T1573 |
747-749 |
IN |
denotes |
of |
| T1574 |
750-753 |
DT |
denotes |
the |
| T1575 |
770-777 |
NNS |
denotes |
enzymes |
| T1576 |
754-759 |
JJ |
denotes |
human |
| T1577 |
760-763 |
CC |
denotes |
and |
| T1578 |
764-769 |
NN |
denotes |
mouse |
| T1579 |
785-787 |
CD |
denotes |
88 |
| T1580 |
787-788 |
NN |
denotes |
% |
| T5977 |
1020-1029 |
JJ |
denotes |
mammalian |
| T5978 |
1040-1047 |
NN |
denotes |
enzymes |
| T5979 |
1030-1034 |
NN |
denotes |
CLN2 |
| T5980 |
1035-1039 |
JJ |
denotes |
like |
| T5981 |
1034-1035 |
HYPH |
denotes |
- |
| T5982 |
1047-1048 |
. |
denotes |
. |
| T5983 |
1049-1054 |
DT |
denotes |
These |
| T5984 |
1055-1064 |
NNS |
denotes |
sequences |
| T5985 |
1049-1126 |
sentence |
denotes |
These sequences correspond to the complete enzymes, including the prosegment. |
| T5986 |
1065-1075 |
VBP |
denotes |
correspond |
| T5987 |
1076-1078 |
IN |
denotes |
to |
| T5988 |
1079-1082 |
DT |
denotes |
the |
| T5989 |
1092-1099 |
NNS |
denotes |
enzymes |
| T5990 |
1083-1091 |
JJ |
denotes |
complete |
| T5991 |
1099-1101 |
, |
denotes |
, |
| T5992 |
1101-1110 |
VBG |
denotes |
including |
| T5993 |
1111-1114 |
DT |
denotes |
the |
| T5994 |
1115-1125 |
NN |
denotes |
prosegment |
| T5995 |
1125-1126 |
. |
denotes |
. |
| T5996 |
1126-1438 |
sentence |
denotes |
Residues forming the active site are shown in yellow on red background, other conserved residues identified as important for the stability of the enzyme are marked with yellow background, residues identical in at least 5 of the structures are green, and residues similar in their character are shown in magenta. |
| T5997 |
1127-1135 |
NNS |
denotes |
Residues |
| T5998 |
1164-1169 |
VBN |
denotes |
shown |
| T5999 |
1136-1143 |
VBG |
denotes |
forming |
| T6000 |
1144-1147 |
DT |
denotes |
the |
| T6001 |
1155-1159 |
NN |
denotes |
site |
| T6002 |
1148-1154 |
JJ |
denotes |
active |
| T6003 |
1160-1163 |
VBP |
denotes |
are |
| T6004 |
1170-1172 |
IN |
denotes |
in |
| T6005 |
1173-1179 |
NN |
denotes |
yellow |
| T6006 |
1180-1182 |
IN |
denotes |
on |
| T6007 |
1183-1186 |
JJ |
denotes |
red |
| T6008 |
1187-1197 |
NN |
denotes |
background |
| T6009 |
1197-1199 |
, |
denotes |
, |
| T6010 |
1199-1204 |
JJ |
denotes |
other |
| T6011 |
1215-1223 |
NNS |
denotes |
residues |
| T6012 |
1205-1214 |
VBN |
denotes |
conserved |
| T6013 |
1284-1290 |
VBN |
denotes |
marked |
| T6014 |
1224-1234 |
VBN |
denotes |
identified |
| T6015 |
1235-1237 |
IN |
denotes |
as |
| T6016 |
1238-1247 |
JJ |
denotes |
important |
| T6017 |
1248-1251 |
IN |
denotes |
for |
| T6018 |
1252-1255 |
DT |
denotes |
the |
| T6019 |
1256-1265 |
NN |
denotes |
stability |
| T6020 |
1266-1268 |
IN |
denotes |
of |
| T6021 |
1269-1272 |
DT |
denotes |
the |
| T6022 |
1273-1279 |
NN |
denotes |
enzyme |
| T6023 |
1280-1283 |
VBP |
denotes |
are |
| T6024 |
1291-1295 |
IN |
denotes |
with |
| T6025 |
1296-1302 |
JJ |
denotes |
yellow |
| T6026 |
1303-1313 |
NN |
denotes |
background |
| T6027 |
1313-1315 |
, |
denotes |
, |
| T6028 |
1315-1323 |
NNS |
denotes |
residues |
| T6029 |
1366-1369 |
VBP |
denotes |
are |
| T6030 |
1324-1333 |
JJ |
denotes |
identical |
| T6031 |
1334-1336 |
IN |
denotes |
in |
| T6032 |
1337-1339 |
RB |
denotes |
at |
| T6033 |
1346-1347 |
CD |
denotes |
5 |
| T6034 |
1340-1345 |
RBS |
denotes |
least |
| T6035 |
1348-1350 |
IN |
denotes |
of |
| T6036 |
1351-1354 |
DT |
denotes |
the |
| T6037 |
1355-1365 |
NNS |
denotes |
structures |
| T6038 |
1370-1375 |
JJ |
denotes |
green |
| T6039 |
1375-1377 |
, |
denotes |
, |
| T6040 |
1377-1380 |
CC |
denotes |
and |
| T6041 |
1381-1389 |
NNS |
denotes |
residues |
| T6042 |
1421-1426 |
VBN |
denotes |
shown |
| T6043 |
1390-1397 |
JJ |
denotes |
similar |
| T6044 |
1398-1400 |
IN |
denotes |
in |
| T6045 |
1401-1406 |
PRP$ |
denotes |
their |
| T6046 |
1407-1416 |
NN |
denotes |
character |
| T6047 |
1417-1420 |
VBP |
denotes |
are |
| T6048 |
1427-1429 |
IN |
denotes |
in |
| T6049 |
1430-1437 |
NN |
denotes |
magenta |
| T6050 |
1437-1438 |
. |
denotes |
. |
| T6051 |
1438-1547 |
sentence |
denotes |
The maturation cleavage point generating the N terminus of the active enzyme is marked with black triangles. |
| T6052 |
1439-1442 |
DT |
denotes |
The |
| T6053 |
1463-1468 |
NN |
denotes |
point |
| T6054 |
1443-1453 |
NN |
denotes |
maturation |
| T6055 |
1454-1462 |
NN |
denotes |
cleavage |
| T6056 |
1519-1525 |
VBN |
denotes |
marked |
| T6057 |
1469-1479 |
VBG |
denotes |
generating |
| T6058 |
1480-1483 |
DT |
denotes |
the |
| T6059 |
1486-1494 |
NN |
denotes |
terminus |
| T6060 |
1484-1485 |
NN |
denotes |
N |
| T6061 |
1495-1497 |
IN |
denotes |
of |
| T6062 |
1498-1501 |
DT |
denotes |
the |
| T6063 |
1509-1515 |
NN |
denotes |
enzyme |
| T6064 |
1502-1508 |
JJ |
denotes |
active |
| T6065 |
1516-1518 |
VBZ |
denotes |
is |
| T6066 |
1526-1530 |
IN |
denotes |
with |
| T6067 |
1531-1536 |
JJ |
denotes |
black |
| T6068 |
1537-1546 |
NNS |
denotes |
triangles |
| T6069 |
1546-1547 |
. |
denotes |
. |
| T1581 |
789-797 |
NN |
denotes |
identity |
| T1582 |
798-801 |
CC |
denotes |
and |
| T1583 |
802-804 |
CD |
denotes |
94 |
| T1584 |
804-805 |
NN |
denotes |
% |
| T1585 |
806-816 |
NN |
denotes |
similarity |
| T1586 |
816-818 |
, |
denotes |
, |
| T1587 |
818-830 |
RB |
denotes |
considerably |
| T1588 |
831-837 |
JJR |
denotes |
higher |
| T1589 |
838-842 |
IN |
denotes |
than |
| T1590 |
843-846 |
DT |
denotes |
the |
| T1591 |
860-868 |
NN |
denotes |
identity |
| T1592 |
847-853 |
JJ |
denotes |
median |
| T1593 |
854-858 |
CD |
denotes |
78.5 |
| T1594 |
858-859 |
NN |
denotes |
% |
| T1595 |
869-877 |
VBN |
denotes |
reported |
| T1596 |
878-881 |
IN |
denotes |
for |
| T1597 |
882-885 |
DT |
denotes |
all |
| T1598 |
909-918 |
NNS |
denotes |
orthologs |
| T1599 |
886-896 |
VBN |
denotes |
identified |
| T1600 |
897-902 |
NN |
denotes |
mouse |
| T1601 |
903-908 |
JJ |
denotes |
human |
| T1602 |
902-903 |
HYPH |
denotes |
- |
| T1603 |
919-920 |
-LRB- |
denotes |
[ |
| T1604 |
920-922 |
CD |
denotes |
13 |
| T1605 |
922-923 |
-RRB- |
denotes |
] |
| T1606 |
923-924 |
. |
denotes |
. |
| T1607 |
924-986 |
sentence |
denotes |
Thus, mammalian CLN2 appears to be a highly conserved enzyme. |
| T1608 |
925-929 |
RB |
denotes |
Thus |
| T1609 |
946-953 |
VBZ |
denotes |
appears |
| T1610 |
929-931 |
, |
denotes |
, |
| T1611 |
931-940 |
JJ |
denotes |
mammalian |
| T1612 |
941-945 |
NN |
denotes |
CLN2 |
| T1613 |
954-956 |
TO |
denotes |
to |
| T1614 |
957-959 |
VB |
denotes |
be |
| T1615 |
960-961 |
DT |
denotes |
a |
| T1616 |
979-985 |
NN |
denotes |
enzyme |
| T1617 |
962-968 |
RB |
denotes |
highly |
| T1618 |
969-978 |
VBN |
denotes |
conserved |
| T1619 |
985-986 |
. |
denotes |
. |
| T1620 |
986-987 |
sentence |
denotes |
|
| R746 |
T1425 |
T1426 |
amod |
Mammalian,enzymes |
| R747 |
T1426 |
T1427 |
nsubj |
enzymes,form |
| R748 |
T1428 |
T1426 |
amod |
homologous,enzymes |
| R749 |
T1429 |
T1428 |
prep |
to,homologous |
| R750 |
T1430 |
T1431 |
amod |
human,CLN2 |
| R751 |
T1431 |
T1429 |
pobj |
CLN2,to |
| R752 |
T1432 |
T1433 |
punct |
[,4 |
| R753 |
T1433 |
T1426 |
parataxis |
4,enzymes |
| R756 |
T1436 |
T1433 |
punct |
],4 |
| R757 |
T1437 |
T1438 |
det |
a,subfamily |
| R758 |
T1438 |
T1427 |
dobj |
subfamily,form |
| R759 |
T1439 |
T1438 |
prep |
of,subfamily |
| R760 |
T1440 |
T1439 |
pobj |
sedolisins,of |
| R761 |
T1441 |
T1440 |
prep |
with,sedolisins |
| R762 |
T1442 |
T1443 |
advmod |
highly,conserved |
| R763 |
T1443 |
T1444 |
amod |
conserved,sequences |
| R764 |
T1444 |
T1441 |
pobj |
sequences,with |
| R765 |
T1445 |
T1446 |
punct |
(,Figure |
| R766 |
T1446 |
T1427 |
parataxis |
Figure,form |
| R767 |
T1447 |
T1446 |
nummod |
1,Figure |
| R768 |
T1448 |
T1446 |
punct |
),Figure |
| R769 |
T1449 |
T1427 |
punct |
.,form |
| R770 |
T1451 |
T1452 |
det |
These,enzymes |
| R771 |
T1452 |
T1453 |
nsubjpass |
enzymes,expressed |
| R772 |
T1454 |
T1453 |
auxpass |
are,expressed |
| R773 |
T1455 |
T1453 |
prep |
with,expressed |
| R774 |
T1456 |
T1457 |
det |
a,prosegment |
| R775 |
T1457 |
T1455 |
pobj |
prosegment,with |
| R776 |
T1458 |
T1457 |
acl |
consisting,prosegment |
| R777 |
T1459 |
T1458 |
prep |
of,consisting |
| R778 |
T1460 |
T1461 |
nummod |
195,residues |
| R779 |
T1461 |
T1459 |
pobj |
residues,of |
| R780 |
T1462 |
T1463 |
dep |
that,cleaved |
| R781 |
T1463 |
T1457 |
relcl |
cleaved,prosegment |
| R783 |
T1465 |
T1463 |
prt |
off,cleaved |
| R784 |
T1466 |
T1463 |
prep |
during,cleaved |
| R785 |
T1467 |
T1466 |
pobj |
maturation,during |
| R786 |
T1468 |
T1463 |
punct |
", ",cleaved |
| R787 |
T1469 |
T1463 |
advcl |
yielding,cleaved |
| R788 |
T1470 |
T1471 |
det |
the,domain |
| R789 |
T1471 |
T1469 |
dobj |
domain,yielding |
| R792 |
T1474 |
T1453 |
punct |
.,expressed |
| R793 |
T1476 |
T1477 |
amod |
Complete,sequences |
| R794 |
T1477 |
T1478 |
nsubj |
sequences,are |
| R795 |
T1479 |
T1478 |
acomp |
available,are |
| R796 |
T1480 |
T1478 |
prep |
for,are |
| R797 |
T1481 |
T1480 |
pobj |
CLN2,for |
| R798 |
T1482 |
T1478 |
prep |
from,are |
| R799 |
T1483 |
T1484 |
nummod |
six,species |
| R800 |
T1484 |
T1482 |
pobj |
species,from |
| R801 |
T1485 |
T1486 |
prep |
in,found |
| R802 |
T1486 |
T1484 |
relcl |
found,species |
| R807 |
T1491 |
T1492 |
advmod |
so,far |
| R808 |
T1492 |
T1486 |
advmod |
far,found |
| R809 |
T1493 |
T1484 |
punct |
(,species |
| R810 |
T1494 |
T1495 |
amod |
human,macaque |
| R811 |
T1495 |
T1484 |
appos |
macaque,species |
| R813 |
T1497 |
T1495 |
punct |
", ",macaque |
| R814 |
T1498 |
T1495 |
conj |
dog,macaque |
| R815 |
T1499 |
T1498 |
punct |
", ",dog |
| R816 |
T1500 |
T1498 |
conj |
mouse,dog |
| R817 |
T1501 |
T1500 |
punct |
", ",mouse |
| R818 |
T1502 |
T1500 |
conj |
rat,mouse |
| R819 |
T1503 |
T1502 |
punct |
", ",rat |
| R820 |
T1504 |
T1502 |
cc |
and,rat |
| R821 |
T1505 |
T1502 |
conj |
cow,rat |
| R822 |
T1506 |
T1478 |
punct |
),are |
| R823 |
T1507 |
T1478 |
punct |
.,are |
| R824 |
T1509 |
T1510 |
det |
The,enzymes |
| R825 |
T1510 |
T1514 |
nsubj |
enzymes,consist |
| R827 |
T1512 |
T1510 |
compound |
length,enzymes |
| R828 |
T1513 |
T1512 |
punct |
-,length |
| R829 |
T1515 |
T1514 |
prep |
of,consist |
| R830 |
T1516 |
T1517 |
nummod |
563,acids |
| R831 |
T1517 |
T1515 |
pobj |
acids,of |
| R833 |
T1519 |
T1517 |
acl |
arranged,acids |
| R834 |
T1520 |
T1519 |
prep |
in,arranged |
| R835 |
T1521 |
T1522 |
det |
a,chain |
| R836 |
T1522 |
T1520 |
pobj |
chain,in |
| R839 |
T1525 |
T1522 |
acl |
containing,chain |
| R840 |
T1526 |
T1527 |
preconj |
both,prosegment |
| R841 |
T1527 |
T1525 |
dobj |
prosegment,containing |
| R843 |
T1529 |
T1527 |
cc |
and,prosegment |
| R844 |
T1530 |
T1531 |
det |
the,catalytic |
| R845 |
T1531 |
T1532 |
nmod |
catalytic,domain |
| R846 |
T1532 |
T1527 |
conj |
domain,prosegment |
| R847 |
T1533 |
T1522 |
punct |
", ",chain |
| R848 |
T1534 |
T1522 |
prep |
with,chain |
| R849 |
T1535 |
T1536 |
det |
the,exception |
| R850 |
T1536 |
T1534 |
pobj |
exception,with |
| R851 |
T1537 |
T1536 |
prep |
of,exception |
| R852 |
T1538 |
T1539 |
compound |
mouse,CLN2 |
| R853 |
T1539 |
T1537 |
pobj |
CLN2,of |
| R854 |
T1540 |
T1541 |
dep |
that,has |
| R855 |
T1541 |
T1539 |
relcl |
has,CLN2 |
| R856 |
T1542 |
T1543 |
det |
a,deletion |
| R857 |
T1543 |
T1541 |
dobj |
deletion,has |
| R859 |
T1545 |
T1541 |
prep |
in,has |
| R860 |
T1546 |
T1547 |
det |
the,prosegment |
| R861 |
T1547 |
T1545 |
pobj |
prosegment,in |
| R862 |
T1548 |
T1514 |
punct |
.,consist |
| R884 |
T1574 |
T1575 |
det |
the,enzymes |
| R885 |
T1575 |
T1573 |
pobj |
enzymes,of |
| R889 |
T1579 |
T1580 |
nummod |
88,% |
| R890 |
T1580 |
T1581 |
compound |
%,identity |
| R891 |
T1581 |
T1572 |
dobj |
identity,yields |
| R892 |
T1582 |
T1581 |
cc |
and,identity |
| R893 |
T1583 |
T1584 |
nummod |
94,% |
| R894 |
T1584 |
T1585 |
compound |
%,similarity |
| R895 |
T1585 |
T1581 |
conj |
similarity,identity |
| R896 |
T1586 |
T1581 |
punct |
", ",identity |
| R897 |
T1587 |
T1588 |
advmod |
considerably,higher |
| R898 |
T1588 |
T1581 |
amod |
higher,identity |
| R899 |
T1589 |
T1588 |
prep |
than,higher |
| R900 |
T1590 |
T1591 |
det |
the,identity |
| R901 |
T1591 |
T1589 |
pobj |
identity,than |
| R905 |
T1595 |
T1591 |
acl |
reported,identity |
| R906 |
T1596 |
T1595 |
prep |
for,reported |
| R907 |
T1597 |
T1598 |
det |
all,orthologs |
| R908 |
T1598 |
T1596 |
pobj |
orthologs,for |
| R911 |
T1601 |
T1598 |
amod |
human,orthologs |
| R912 |
T1602 |
T1601 |
punct |
-,human |
| R913 |
T1603 |
T1604 |
punct |
[,13 |
| R914 |
T1604 |
T1572 |
parataxis |
13,yields |
| R915 |
T1605 |
T1604 |
punct |
],13 |
| R916 |
T1606 |
T1572 |
punct |
.,yields |
| R917 |
T1608 |
T1609 |
advmod |
Thus,appears |
| R918 |
T1610 |
T1609 |
punct |
", ",appears |
| R919 |
T1611 |
T1612 |
amod |
mammalian,CLN2 |
| R920 |
T1612 |
T1609 |
nsubj |
CLN2,appears |
| R921 |
T1613 |
T1614 |
aux |
to,be |
| R922 |
T1614 |
T1609 |
xcomp |
be,appears |
| R923 |
T1615 |
T1616 |
det |
a,enzyme |
| R924 |
T1616 |
T1614 |
attr |
enzyme,be |
| R927 |
T1619 |
T1609 |
punct |
.,appears |
| R4237 |
T5977 |
T5978 |
amod |
mammalian,enzymes |
| R4239 |
T5979 |
T5980 |
npadvmod |
CLN2,like |
| R4240 |
T5980 |
T5978 |
amod |
like,enzymes |
| R4241 |
T5981 |
T5980 |
punct |
-,like |
| R4243 |
T5983 |
T5984 |
det |
These,sequences |
| R4244 |
T5984 |
T5986 |
nsubj |
sequences,correspond |
| R4245 |
T5987 |
T5986 |
prep |
to,correspond |
| R4246 |
T5988 |
T5989 |
det |
the,enzymes |
| R4247 |
T5989 |
T5987 |
pobj |
enzymes,to |
| R4248 |
T5990 |
T5989 |
amod |
complete,enzymes |
| R4249 |
T5991 |
T5989 |
punct |
", ",enzymes |
| R4250 |
T5992 |
T5989 |
prep |
including,enzymes |
| R4251 |
T5993 |
T5994 |
det |
the,prosegment |
| R4252 |
T5994 |
T5992 |
pobj |
prosegment,including |
| R4253 |
T5995 |
T5986 |
punct |
.,correspond |
| R4254 |
T5997 |
T5998 |
nsubjpass |
Residues,shown |
| R4255 |
T5999 |
T5997 |
acl |
forming,Residues |
| R4256 |
T6000 |
T6001 |
det |
the,site |
| R4257 |
T6001 |
T5999 |
dobj |
site,forming |
| R4258 |
T6002 |
T6001 |
amod |
active,site |
| R4259 |
T6003 |
T5998 |
auxpass |
are,shown |
| R4260 |
T6004 |
T5998 |
prep |
in,shown |
| R4261 |
T6005 |
T6004 |
pobj |
yellow,in |
| R4262 |
T6006 |
T5998 |
prep |
on,shown |
| R4263 |
T6007 |
T6008 |
amod |
red,background |
| R4264 |
T6008 |
T6006 |
pobj |
background,on |
| R4265 |
T6009 |
T5998 |
punct |
", ",shown |
| R4266 |
T6010 |
T6011 |
amod |
other,residues |
| R4267 |
T6011 |
T6013 |
nsubjpass |
residues,marked |
| R4268 |
T6012 |
T6011 |
amod |
conserved,residues |
| R4269 |
T6013 |
T5998 |
conj |
marked,shown |
| R4270 |
T6014 |
T6011 |
acl |
identified,residues |
| R4271 |
T6015 |
T6014 |
prep |
as,identified |
| R4272 |
T6016 |
T6015 |
amod |
important,as |
| R4273 |
T6017 |
T6016 |
prep |
for,important |
| R4274 |
T6018 |
T6019 |
det |
the,stability |
| R4275 |
T6019 |
T6017 |
pobj |
stability,for |
| R4276 |
T6020 |
T6019 |
prep |
of,stability |
| R4277 |
T6021 |
T6022 |
det |
the,enzyme |
| R4278 |
T6022 |
T6020 |
pobj |
enzyme,of |
| R4279 |
T6023 |
T6013 |
auxpass |
are,marked |
| R4280 |
T6024 |
T6013 |
prep |
with,marked |
| R4281 |
T6025 |
T6026 |
amod |
yellow,background |
| R4282 |
T6026 |
T6024 |
pobj |
background,with |
| R4283 |
T6027 |
T6013 |
punct |
", ",marked |
| R4284 |
T6028 |
T6029 |
nsubj |
residues,are |
| R4285 |
T6029 |
T6013 |
conj |
are,marked |
| R4286 |
T6030 |
T6028 |
relcl |
identical,residues |
| R4287 |
T6031 |
T6030 |
prep |
in,identical |
| R4288 |
T6032 |
T6033 |
quantmod |
at,5 |
| R4289 |
T6033 |
T6031 |
pobj |
5,in |
| R4290 |
T6034 |
T6032 |
advmod |
least,at |
| R4291 |
T6035 |
T6033 |
prep |
of,5 |
| R4292 |
T6036 |
T6037 |
det |
the,structures |
| R4293 |
T6037 |
T6035 |
pobj |
structures,of |
| R4294 |
T6038 |
T6029 |
acomp |
green,are |
| R4295 |
T6039 |
T6029 |
punct |
", ",are |
| R4296 |
T6040 |
T6029 |
cc |
and,are |
| R4297 |
T6041 |
T6042 |
nsubjpass |
residues,shown |
| R4298 |
T6042 |
T6029 |
conj |
shown,are |
| R4299 |
T6043 |
T6041 |
amod |
similar,residues |
| R4300 |
T6044 |
T6043 |
prep |
in,similar |
| R4301 |
T6045 |
T6046 |
poss |
their,character |
| R4302 |
T6046 |
T6044 |
pobj |
character,in |
| R4303 |
T6047 |
T6042 |
auxpass |
are,shown |
| R4304 |
T6048 |
T6042 |
prep |
in,shown |
| R4305 |
T6049 |
T6048 |
pobj |
magenta,in |
| R4306 |
T6050 |
T6042 |
punct |
.,shown |
| R4307 |
T6052 |
T6053 |
det |
The,point |
| R4308 |
T6053 |
T6056 |
nsubjpass |
point,marked |
| R4309 |
T6054 |
T6053 |
compound |
maturation,point |
| R4310 |
T6055 |
T6053 |
compound |
cleavage,point |
| R4311 |
T6057 |
T6053 |
acl |
generating,point |
| R4312 |
T6058 |
T6059 |
det |
the,terminus |
| R4313 |
T6059 |
T6057 |
dobj |
terminus,generating |
| R4314 |
T6060 |
T6059 |
compound |
N,terminus |
| R4315 |
T6061 |
T6059 |
prep |
of,terminus |
| R4316 |
T6062 |
T6063 |
det |
the,enzyme |
| R4317 |
T6063 |
T6061 |
pobj |
enzyme,of |
| R4318 |
T6064 |
T6063 |
amod |
active,enzyme |
| R4319 |
T6065 |
T6056 |
auxpass |
is,marked |
| R4320 |
T6066 |
T6056 |
prep |
with,marked |
| R4321 |
T6067 |
T6068 |
amod |
black,triangles |
| R4322 |
T6068 |
T6066 |
pobj |
triangles,with |
| R4323 |
T6069 |
T6056 |
punct |
.,marked |
| R858 |
T1544 |
T1543 |
amod |
single,deletion |
| R865 |
T1552 |
T1551 |
amod |
overall,identity |
| R866 |
T1553 |
T1551 |
compound |
sequence,identity |
| R875 |
T1563 |
T1564 |
det |
the,similarity |
| R876 |
T1564 |
T1562 |
nsubj |
similarity,is |
| R882 |
T1571 |
T1570 |
amod |
pairwise,comparison |
| R886 |
T1576 |
T1575 |
amod |
human,enzymes |
| R887 |
T1577 |
T1576 |
cc |
and,human |
| R888 |
T1578 |
T1576 |
conj |
mouse,human |
| R902 |
T1592 |
T1591 |
amod |
median,identity |
| R903 |
T1593 |
T1594 |
nummod |
78.5,% |
| R904 |
T1594 |
T1591 |
compound |
%,identity |
| R909 |
T1599 |
T1598 |
amod |
identified,orthologs |
| R910 |
T1600 |
T1601 |
npadvmod |
mouse,human |
| R925 |
T1617 |
T1618 |
advmod |
highly,conserved |
| R926 |
T1618 |
T1616 |
amod |
conserved,enzyme |
| R863 |
T1550 |
T1551 |
det |
The,identity |
| R864 |
T1551 |
T1554 |
nsubj |
identity,is |
| R867 |
T1555 |
T1551 |
prep |
for,identity |
| R868 |
T1556 |
T1557 |
det |
these,enzymes |
| R869 |
T1557 |
T1555 |
pobj |
enzymes,for |
| R870 |
T1558 |
T1559 |
nummod |
81,% |
| R871 |
T1559 |
T1554 |
attr |
%,is |
| R872 |
T1560 |
T1554 |
punct |
", ",is |
| R873 |
T1561 |
T1562 |
mark |
whereas,is |
| R874 |
T1562 |
T1554 |
advcl |
is,is |
| R877 |
T1565 |
T1566 |
nummod |
92,% |
| R878 |
T1566 |
T1562 |
attr |
%,is |
| R879 |
T1567 |
T1554 |
punct |
.,is |
| R880 |
T1569 |
T1570 |
det |
A,comparison |
| R881 |
T1570 |
T1572 |
nsubj |
comparison,yields |
| R883 |
T1573 |
T1570 |
prep |
of,comparison |
| R754 |
T1434 |
T1433 |
nummod |
2,4 |
| R755 |
T1435 |
T1433 |
punct |
",",4 |
| R782 |
T1464 |
T1463 |
auxpass |
is,cleaved |
| R790 |
T1472 |
T1471 |
amod |
active,domain |
| R791 |
T1473 |
T1471 |
amod |
catalytic,domain |
| R803 |
T1487 |
T1485 |
pobj |
which,in |
| R804 |
T1488 |
T1486 |
nsubjpass |
it,found |
| R805 |
T1489 |
T1486 |
aux |
has,found |
| R806 |
T1490 |
T1486 |
auxpass |
been,found |
| R812 |
T1496 |
T1495 |
punct |
", ",macaque |
| R826 |
T1511 |
T1512 |
amod |
full,length |
| R832 |
T1518 |
T1517 |
compound |
amino,acids |
| R837 |
T1523 |
T1522 |
amod |
single,chain |
| R838 |
T1524 |
T1522 |
compound |
polypeptide,chain |
| R842 |
T1528 |
T1527 |
det |
the,prosegment |