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PMC:280685 / 148-1844 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T53 11-34 PR:000016585 denotes Tripeptidyl-peptidase I
T54 50-54 PR:000016585 denotes CLN2
T55 129-135 NCBITaxon:9606 denotes humans
T56 148-158 GO:0010467 denotes expression
T57 242-250 CL:0000540 denotes neuronal
T58 313-320 SO:0001026 denotes genomic
T59 342-349 NCBITaxon:species denotes species
T60 512-521 SO:0000855 denotes orthologs
T61 525-530 NCBITaxon:9606 denotes human
T62 531-535 PR:000016585 denotes CLN2
T63 543-550 SO:0001026 denotes genomic
T64 576-586 NCBITaxon:2759 denotes eukaryotic
T65 587-594 NCBITaxon:species denotes species
T66 668-675 SO:0001026 denotes genomes
T67 679-686 NCBITaxon:9539 denotes macaque
T68 688-693 NCBITaxon:10088 denotes mouse
T69 695-698 NCBITaxon:10114 denotes rat
T70 700-703 NCBITaxon:9615 denotes dog
T71 709-712 NCBITaxon:9913 denotes cow
T72 787-791 NCBITaxon:31032 denotes fugu
T73 796-801 NCBITaxon:7955 denotes zebra
T74 818-823 NCBITaxon:8342 denotes frogs
T75 825-843 NCBITaxon:8364 denotes Xenopus tropicalis
T76 875-880 NCBITaxon:9606 denotes human
T77 881-885 PR:000016585 denotes CLN2
T78 916-924 SO:0000857 denotes homology
T79 930-941 NCBITaxon:286 denotes Pseudomonas
T80 942-945 NCBITaxon:species denotes sp.
T81 973-977 PR:000016585 denotes CLN2
T82 1039-1048 NCBITaxon:1 denotes organisms
T83 1089-1100 UBERON:0000104 denotes life cycles
T84 1164-1175 SO:0100019 denotes active site
T85 1228-1232 PR:000016585 denotes CLN2
T86 1506-1516 CHEBI:35222 denotes inhibitors
T87 1520-1524 PR:000016585 denotes CLN2

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T88 1039-1048 NCBITaxon:1 denotes organisms
T97 11-22 CHEBI_SO_EXT:tripeptide denotes Tripeptidyl
T98 11-32 GO_EXT:0008240 denotes Tripeptidyl-peptidase
T99 11-34 PR_EXT:000016585 denotes Tripeptidyl-peptidase I
T100 50-54 PR_EXT:000016585 denotes CLN2
T101 97-103 CHEBI_SO_EXT:serine denotes serine
T102 97-123 GO_EXT:0004185 denotes serine-carboxyl peptidases
T103 104-112 CHEBI_EXT:carboxy_or_carboxylato_group denotes carboxyl
T104 129-135 NCBITaxon:9606 denotes humans
T105 148-158 GO:0010467 denotes expression
T106 167-173 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T107 184-189 GO_EXT:fatality_or_lethality denotes fatal
T108 232-241 UBERON_EXT:baby_or_infant denotes infantile
T109 242-250 CL:0000540 denotes neuronal
T110 282-289 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T111 313-320 SO_EXT:0001026 denotes genomic
T112 321-330 SO_EXT:biological_sequence denotes sequences
T113 342-349 NCBITaxon:species denotes species
T114 512-521 SO_EXT:0000855 denotes orthologs
T115 525-530 NCBITaxon:9606 denotes human
T116 531-535 PR_EXT:000016585 denotes CLN2
T117 543-550 SO_EXT:0001026 denotes genomic
T118 551-560 SO_EXT:biological_sequence denotes sequences
T119 576-586 NCBITaxon:2759 denotes eukaryotic
T120 587-594 NCBITaxon:species denotes species
T121 596-603 CHEBI_GO_SO_EXT:enzyme denotes Enzymes
T122 609-618 SO_EXT:biological_sequence denotes sequences
T123 668-675 SO_EXT:0001026 denotes genomes
T124 679-686 NCBITaxon:9539 denotes macaque
T125 688-693 NCBITaxon:10088 denotes mouse
T126 695-698 NCBITaxon:10114 denotes rat
T127 700-703 NCBITaxon:9615 denotes dog
T128 709-712 NCBITaxon:9913 denotes cow
T129 758-765 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T130 781-785 NCBITaxon_EXT:fish denotes fish
T131 787-791 NCBITaxon:31032 denotes fugu
T132 796-801 NCBITaxon:7955 denotes zebra
T133 818-823 NCBITaxon:8342 denotes frogs
T134 825-843 NCBITaxon:8364 denotes Xenopus tropicalis
T135 875-880 NCBITaxon:9606 denotes human
T136 881-885 PR_EXT:000016585 denotes CLN2
T137 916-924 SO:0000857 denotes homology
T138 930-941 NCBITaxon:286 denotes Pseudomonas
T139 942-945 NCBITaxon:species denotes sp.
T140 973-977 PR_EXT:000016585 denotes CLN2
T141 993-1002 SO_EXT:biological_conservation_process_or_quality denotes conserved
T149 1429-1442 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T150 1463-1470 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T151 1506-1516 CHEBI_EXT:35222 denotes inhibitors
T152 1520-1524 PR_EXT:000016585 denotes CLN2
T142 1089-1100 UBERON:0000104 denotes life cycles
T143 1164-1175 SO_EXT:0100019 denotes active site
T144 1202-1211 SO_EXT:biological_conservation_process_or_quality denotes conserved
T145 1228-1232 PR_EXT:000016585 denotes CLN2
T146 1233-1240 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T147 1282-1294 GO_EXT:0008240 denotes tripeptidase
T148 1336-1343 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding

craft-sa-dev

Id Subject Object Predicate Lexical cue
T181 0-10 sentence denotes Background
T182 0-10 NN denotes Background
T183 10-125 sentence denotes Tripeptidyl-peptidase I, also known as CLN2, is a member of the family of sedolisins (serine-carboxyl peptidases).
T184 11-22 NN denotes Tripeptidyl
T185 23-32 NN denotes peptidase
T186 22-23 HYPH denotes -
T187 56-58 VBZ denotes is
T188 33-34 CD denotes I
T189 34-36 , denotes ,
T190 36-40 RB denotes also
T191 41-46 VBN denotes known
T192 47-49 IN denotes as
T193 50-54 NN denotes CLN2
T194 54-56 , denotes ,
T195 59-60 DT denotes a
T196 61-67 NN denotes member
T197 68-70 IN denotes of
T198 71-74 DT denotes the
T199 75-81 NN denotes family
T200 82-84 IN denotes of
T201 85-95 NNS denotes sedolisins
T202 96-97 -LRB- denotes (
T203 97-103 NN denotes serine
T204 104-112 NN denotes carboxyl
T205 103-104 HYPH denotes -
T206 113-123 NNS denotes peptidases
T207 123-124 -RRB- denotes )
T208 124-125 . denotes .
T209 125-273 sentence denotes In humans, defects in expression of this enzyme lead to a fatal neurodegenerative disease, classical late-infantile neuronal ceroid lipofuscinosis.
T210 126-128 IN denotes In
T211 174-178 VBP denotes lead
T212 129-135 NNS denotes humans
T213 135-137 , denotes ,
T214 137-144 VBZ denotes defects
T215 145-147 IN denotes in
T216 148-158 NN denotes expression
T217 159-161 IN denotes of
T218 162-166 DT denotes this
T219 167-173 NN denotes enzyme
T220 179-181 IN denotes to
T221 182-183 DT denotes a
T222 208-215 NN denotes disease
T223 184-189 JJ denotes fatal
T224 190-207 JJ denotes neurodegenerative
T225 215-217 , denotes ,
T226 217-226 JJ denotes classical
T227 258-272 NN denotes lipofuscinosis
T228 227-231 JJ denotes late
T229 232-241 JJ denotes infantile
T230 231-232 HYPH denotes -
T231 242-250 JJ denotes neuronal
T232 251-257 JJ denotes ceroid
T233 272-273 . denotes .
T234 273-469 sentence denotes Similar enzymes have been found in the genomic sequences of several species, but neither systematic analyses of their distribution nor modeling of their structures have been previously attempted.
T235 274-281 JJ denotes Similar
T236 282-289 NNS denotes enzymes
T237 300-305 VBN denotes found
T238 290-294 VBP denotes have
T239 295-299 VBN denotes been
T240 306-308 IN denotes in
T241 309-312 DT denotes the
T242 321-330 NNS denotes sequences
T243 313-320 JJ denotes genomic
T244 331-333 IN denotes of
T245 334-341 JJ denotes several
T246 342-349 NNS denotes species
T247 349-351 , denotes ,
T248 351-354 CC denotes but
T249 355-362 CC denotes neither
T250 374-382 NNS denotes analyses
T251 363-373 JJ denotes systematic
T252 459-468 VBN denotes attempted
T253 383-385 IN denotes of
T254 386-391 PRP$ denotes their
T255 392-404 NN denotes distribution
T256 405-408 CC denotes nor
T257 409-417 NN denotes modeling
T258 418-420 IN denotes of
T259 421-426 PRP$ denotes their
T260 427-437 NNS denotes structures
T261 438-442 VBP denotes have
T262 443-447 VBN denotes been
T263 448-458 RB denotes previously
T264 468-469 . denotes .
T265 469-478 sentence denotes Results
T266 471-478 NNS denotes Results
T267 478-595 sentence denotes We have analyzed the presence of orthologs of human CLN2 in the genomic sequences of a number of eukaryotic species.
T268 479-481 PRP denotes We
T269 487-495 VBN denotes analyzed
T270 482-486 VBP denotes have
T271 496-499 DT denotes the
T272 500-508 NN denotes presence
T273 509-511 IN denotes of
T274 512-521 NNS denotes orthologs
T275 522-524 IN denotes of
T276 525-530 JJ denotes human
T277 531-535 NN denotes CLN2
T278 536-538 IN denotes in
T279 539-542 DT denotes the
T280 551-560 NNS denotes sequences
T281 543-550 JJ denotes genomic
T282 561-563 IN denotes of
T283 564-565 DT denotes a
T284 566-572 NN denotes number
T285 573-575 IN denotes of
T286 576-586 JJ denotes eukaryotic
T287 587-594 NNS denotes species
T288 594-595 . denotes .
T289 595-713 sentence denotes Enzymes with sequences sharing over 80% identity have been found in the genomes of macaque, mouse, rat, dog, and cow.
T290 596-603 NNS denotes Enzymes
T291 655-660 VBN denotes found
T292 604-608 IN denotes with
T293 609-618 NNS denotes sequences
T294 619-626 VBG denotes sharing
T295 627-631 IN denotes over
T296 632-634 CD denotes 80
T297 634-635 NN denotes %
T298 636-644 NN denotes identity
T299 645-649 VBP denotes have
T300 650-654 VBN denotes been
T301 661-663 IN denotes in
T302 664-667 DT denotes the
T303 668-675 NNS denotes genomes
T304 676-678 IN denotes of
T305 679-686 NN denotes macaque
T306 686-688 , denotes ,
T307 688-693 NN denotes mouse
T308 693-695 , denotes ,
T309 695-698 NN denotes rat
T310 698-700 , denotes ,
T311 700-703 NN denotes dog
T312 703-705 , denotes ,
T313 705-708 CC denotes and
T314 709-712 NN denotes cow
T315 712-713 . denotes .
T316 713-845 sentence denotes Closely related, although clearly distinct, enzymes are present in fish (fugu and zebra), as well as in frogs (Xenopus tropicalis).
T317 714-721 RB denotes Closely
T318 722-729 VBN denotes related
T319 758-765 NNS denotes enzymes
T320 729-731 , denotes ,
T321 748-756 JJ denotes distinct
T322 731-739 IN denotes although
T323 740-747 RB denotes clearly
T324 756-758 , denotes ,
T325 766-769 VBP denotes are
T326 770-777 JJ denotes present
T327 778-780 IN denotes in
T328 781-785 NN denotes fish
T329 786-787 -LRB- denotes (
T330 787-791 NN denotes fugu
T331 792-795 CC denotes and
T332 796-801 NN denotes zebra
T333 801-802 -RRB- denotes )
T334 802-804 , denotes ,
T335 804-806 RB denotes as
T336 812-814 IN denotes as
T337 807-811 RB denotes well
T338 815-817 IN denotes in
T339 818-823 NNS denotes frogs
T340 824-825 -LRB- denotes (
T341 825-832 NNP denotes Xenopus
T342 833-843 NNP denotes tropicalis
T343 843-844 -RRB- denotes )
T344 844-845 . denotes .
T345 845-945 sentence denotes A three-dimensional model of human CLN2 was built based mainly on the homology with Pseudomonas sp.
T346 846-847 DT denotes A
T347 866-871 NN denotes model
T348 848-853 CD denotes three
T349 854-865 JJ denotes dimensional
T350 853-854 HYPH denotes -
T351 890-895 VBN denotes built
T352 872-874 IN denotes of
T353 875-880 JJ denotes human
T354 881-885 NN denotes CLN2
T355 886-889 VBD denotes was
T356 896-901 VBN denotes based
T357 902-908 RB denotes mainly
T358 909-911 IN denotes on
T359 912-915 DT denotes the
T360 916-924 NN denotes homology
T361 925-929 IN denotes with
T362 930-941 NNP denotes Pseudomonas
T363 942-944 NNP denotes sp
T364 944-945 . denotes .
T365 945-960 sentence denotes 101 sedolisin.
T366 946-949 CD denotes 101
T367 950-959 NN denotes sedolisin
T368 959-960 . denotes .
T369 960-972 sentence denotes Conclusion
T370 962-972 NN denotes Conclusion
T371 972-1101 sentence denotes CLN2 is very highly conserved and widely distributed among higher organisms and may play an important role in their life cycles.
T372 973-977 NN denotes CLN2
T373 993-1002 VBN denotes conserved
T374 978-980 VBZ denotes is
T375 981-985 RB denotes very
T376 986-992 RB denotes highly
T377 1003-1006 CC denotes and
T378 1007-1013 RB denotes widely
T379 1014-1025 VBN denotes distributed
T380 1026-1031 IN denotes among
T381 1032-1038 JJR denotes higher
T382 1039-1048 NNS denotes organisms
T383 1049-1052 CC denotes and
T384 1053-1056 MD denotes may
T385 1057-1061 VB denotes play
T386 1062-1064 DT denotes an
T387 1075-1079 NN denotes role
T388 1065-1074 JJ denotes important
T389 1080-1082 IN denotes in
T390 1083-1088 PRP$ denotes their
T391 1094-1100 NNS denotes cycles
T392 1089-1093 NN denotes life
T393 1100-1101 . denotes .
T394 1101-1241 sentence denotes The model presented here indicates a very open and accessible active site that is almost completely conserved among all known CLN2 enzymes.
T395 1102-1105 DT denotes The
T396 1106-1111 NN denotes model
T397 1127-1136 VBZ denotes indicates
T398 1112-1121 VBN denotes presented
T399 1122-1126 RB denotes here
T400 1137-1138 DT denotes a
T401 1171-1175 NN denotes site
T402 1139-1143 RB denotes very
T403 1144-1148 JJ denotes open
T404 1149-1152 CC denotes and
T405 1153-1163 JJ denotes accessible
T406 1164-1170 JJ denotes active
T407 1176-1180 WDT denotes that
T408 1202-1211 VBN denotes conserved
T409 1181-1183 VBZ denotes is
T410 1184-1190 RB denotes almost
T411 1191-1201 RB denotes completely
T412 1212-1217 IN denotes among
T413 1218-1221 DT denotes all
T414 1233-1240 NNS denotes enzymes
T415 1222-1227 VBN denotes known
T416 1228-1232 NN denotes CLN2
T417 1240-1241 . denotes .
T418 1241-1367 sentence denotes This result is somehow surprising for a tripeptidase where the presence of a more constrained binding pocket was anticipated.
T419 1242-1246 DT denotes This
T420 1247-1253 NN denotes result
T421 1254-1256 VBZ denotes is
T422 1257-1264 RB denotes somehow
T423 1265-1275 JJ denotes surprising
T424 1276-1279 IN denotes for
T425 1280-1281 DT denotes a
T426 1282-1294 NN denotes tripeptidase
T427 1295-1300 WRB denotes where
T428 1355-1366 VBN denotes anticipated
T429 1301-1304 DT denotes the
T430 1305-1313 NN denotes presence
T431 1314-1316 IN denotes of
T432 1317-1318 DT denotes a
T433 1344-1350 NN denotes pocket
T434 1319-1323 RBR denotes more
T435 1324-1335 JJ denotes constrained
T436 1336-1343 NN denotes binding
T437 1351-1354 VBD denotes was
T438 1366-1367 . denotes .
T439 1367-1525 sentence denotes This structural model should be useful in the search for the physiological substrates of these enzymes and in the design of more specific inhibitors of CLN2.
T440 1368-1372 DT denotes This
T441 1384-1389 NN denotes model
T442 1373-1383 JJ denotes structural
T443 1397-1399 VB denotes be
T444 1390-1396 MD denotes should
T445 1400-1406 JJ denotes useful
T446 1407-1409 IN denotes in
T447 1410-1413 DT denotes the
T448 1414-1420 NN denotes search
T449 1421-1424 IN denotes for
T450 1425-1428 DT denotes the
T451 1443-1453 NNS denotes substrates
T452 1429-1442 JJ denotes physiological
T453 1454-1456 IN denotes of
T454 1457-1462 DT denotes these
T455 1463-1470 NNS denotes enzymes
T456 1471-1474 CC denotes and
T457 1475-1477 IN denotes in
T458 1478-1481 DT denotes the
T459 1482-1488 NN denotes design
T460 1489-1491 IN denotes of
T461 1492-1496 JJR denotes more
T462 1506-1516 NNS denotes inhibitors
T463 1497-1505 JJ denotes specific
T464 1517-1519 IN denotes of
T465 1520-1524 NN denotes CLN2
T466 1524-1525 . denotes .
R25 T184 T185 compound Tripeptidyl,peptidase
R26 T185 T187 nsubj peptidase,is
R28 T188 T185 nummod I,peptidase
R29 T189 T185 punct ", ",peptidase
R30 T190 T191 advmod also,known
R31 T191 T185 acl known,peptidase
R32 T192 T191 prep as,known
R33 T193 T192 pobj CLN2,as
R34 T194 T187 punct ", ",is
R35 T195 T196 det a,member
R36 T196 T187 attr member,is
R37 T197 T196 prep of,member
R38 T198 T199 det the,family
R39 T199 T197 pobj family,of
R40 T200 T199 prep of,family
R41 T201 T200 pobj sedolisins,of
R42 T202 T201 punct (,sedolisins
R43 T203 T204 compound serine,carboxyl
R44 T204 T206 compound carboxyl,peptidases
R46 T206 T201 appos peptidases,sedolisins
R47 T207 T187 punct ),is
R48 T208 T187 punct .,is
R49 T210 T211 prep In,lead
R50 T212 T210 pobj humans,In
R51 T213 T211 punct ", ",lead
R52 T214 T211 nsubj defects,lead
R53 T215 T214 prep in,defects
R54 T216 T215 pobj expression,in
R55 T217 T216 prep of,expression
R56 T218 T219 det this,enzyme
R57 T219 T217 pobj enzyme,of
R58 T220 T211 prep to,lead
R59 T221 T222 det a,disease
R60 T222 T220 pobj disease,to
R63 T225 T222 punct ", ",disease
R64 T226 T227 amod classical,lipofuscinosis
R65 T227 T222 appos lipofuscinosis,disease
R67 T229 T227 amod infantile,lipofuscinosis
R68 T230 T229 punct -,infantile
R71 T233 T211 punct .,lead
R72 T235 T236 amod Similar,enzymes
R73 T236 T237 nsubjpass enzymes,found
R74 T238 T237 aux have,found
R75 T239 T237 auxpass been,found
R76 T240 T237 prep in,found
R77 T241 T242 det the,sequences
R78 T242 T240 pobj sequences,in
R80 T244 T242 prep of,sequences
R81 T245 T246 amod several,species
R82 T246 T244 pobj species,of
R83 T247 T237 punct ", ",found
R84 T248 T237 cc but,found
R85 T249 T250 preconj neither,analyses
R86 T250 T252 nsubjpass analyses,attempted
R88 T252 T237 conj attempted,found
R100 T264 T252 punct .,attempted
R101 T268 T269 nsubj We,analyzed
R102 T270 T269 aux have,analyzed
R103 T271 T272 det the,presence
R104 T272 T269 dobj presence,analyzed
R105 T273 T272 prep of,presence
R106 T274 T273 pobj orthologs,of
R107 T275 T274 prep of,orthologs
R108 T276 T277 amod human,CLN2
R109 T277 T275 pobj CLN2,of
R110 T278 T269 prep in,analyzed
R111 T279 T280 det the,sequences
R112 T280 T278 pobj sequences,in
R114 T282 T280 prep of,sequences
R115 T283 T284 det a,number
R116 T284 T282 pobj number,of
R117 T285 T284 prep of,number
R118 T286 T287 amod eukaryotic,species
R119 T287 T285 pobj species,of
R120 T288 T269 punct .,analyzed
R121 T290 T291 nsubjpass Enzymes,found
R122 T292 T290 prep with,Enzymes
R123 T293 T292 pobj sequences,with
R124 T294 T293 acl sharing,sequences
R125 T295 T296 quantmod over,80
R126 T296 T297 nummod 80,%
R127 T297 T298 compound %,identity
R128 T298 T294 dobj identity,sharing
R129 T299 T291 aux have,found
R130 T300 T291 auxpass been,found
R131 T301 T291 prep in,found
R132 T302 T303 det the,genomes
R133 T303 T301 pobj genomes,in
R134 T304 T303 prep of,genomes
R135 T305 T304 pobj macaque,of
R136 T306 T305 punct ", ",macaque
R137 T307 T305 conj mouse,macaque
R138 T308 T307 punct ", ",mouse
R139 T309 T307 conj rat,mouse
R140 T310 T309 punct ", ",rat
R141 T311 T309 conj dog,rat
R142 T312 T311 punct ", ",dog
R143 T313 T311 cc and,dog
R144 T314 T311 conj cow,dog
R145 T315 T291 punct .,found
R146 T317 T318 advmod Closely,related
R147 T318 T319 amod related,enzymes
R148 T319 T325 nsubj enzymes,are
R150 T321 T318 parataxis distinct,related
R151 T322 T321 mark although,distinct
R152 T323 T321 advmod clearly,distinct
R154 T326 T325 acomp present,are
R155 T327 T325 prep in,are
R156 T328 T327 pobj fish,in
R157 T329 T328 punct (,fish
R158 T330 T328 appos fugu,fish
R159 T331 T330 cc and,fugu
R160 T332 T330 conj zebra,fugu
R161 T333 T327 punct ),in
R162 T334 T327 punct ", ",in
R163 T335 T336 advmod as,as
R164 T336 T327 cc as,in
R166 T338 T327 conj in,in
R167 T339 T338 pobj frogs,in
R168 T340 T339 punct (,frogs
R169 T341 T342 compound Xenopus,tropicalis
R170 T342 T339 appos tropicalis,frogs
R171 T343 T325 punct ),are
R172 T344 T325 punct .,are
R173 T346 T347 det A,model
R174 T347 T351 nsubjpass model,built
R176 T349 T347 amod dimensional,model
R177 T350 T349 punct -,dimensional
R178 T352 T347 prep of,model
R179 T353 T354 amod human,CLN2
R180 T354 T352 pobj CLN2,of
R181 T355 T351 auxpass was,built
R182 T356 T351 prep based,built
R183 T357 T358 advmod mainly,on
R184 T358 T356 prep on,based
R185 T359 T360 det the,homology
R186 T360 T358 pobj homology,on
R187 T361 T360 prep with,homology
R188 T362 T363 compound Pseudomonas,sp
R189 T363 T361 pobj sp,with
R190 T364 T351 punct .,built
R191 T366 T367 nummod 101,sedolisin
R192 T368 T367 punct .,sedolisin
R193 T372 T373 nsubj CLN2,conserved
R194 T374 T373 aux is,conserved
R195 T375 T376 advmod very,highly
R196 T376 T373 advmod highly,conserved
R197 T377 T373 cc and,conserved
R198 T378 T379 advmod widely,distributed
R199 T379 T373 conj distributed,conserved
R200 T380 T373 prep among,conserved
R201 T381 T382 amod higher,organisms
R202 T382 T380 pobj organisms,among
R203 T383 T373 cc and,conserved
R204 T384 T385 aux may,play
R205 T385 T373 conj play,conserved
R206 T386 T387 det an,role
R207 T387 T385 dobj role,play
R209 T389 T385 prep in,play
R210 T390 T391 poss their,cycles
R211 T391 T389 pobj cycles,in
R213 T393 T373 punct .,conserved
R214 T395 T396 det The,model
R215 T396 T397 nsubj model,indicates
R216 T398 T396 acl presented,model
R217 T399 T398 advmod here,presented
R218 T400 T401 det a,site
R219 T401 T397 dobj site,indicates
R225 T407 T408 dep that,conserved
R226 T408 T401 relcl conserved,site
R230 T412 T408 prep among,conserved
R231 T413 T414 det all,enzymes
R232 T414 T412 pobj enzymes,among
R235 T417 T397 punct .,indicates
R236 T419 T420 det This,result
R237 T420 T421 nsubj result,is
R238 T422 T421 advmod somehow,is
R239 T423 T421 acomp surprising,is
R240 T424 T421 prep for,is
R241 T425 T426 det a,tripeptidase
R242 T426 T424 pobj tripeptidase,for
R243 T427 T428 advmod where,anticipated
R244 T428 T426 relcl anticipated,tripeptidase
R249 T433 T431 pobj pocket,of
R250 T434 T435 advmod more,constrained
R251 T435 T433 amod constrained,pocket
R252 T436 T433 compound binding,pocket
R254 T438 T421 punct .,is
R255 T440 T441 det This,model
R256 T441 T443 nsubj model,be
R258 T444 T443 aux should,be
R259 T445 T443 acomp useful,be
R260 T446 T443 prep in,be
R261 T447 T448 det the,search
R262 T448 T446 pobj search,in
R263 T449 T448 prep for,search
R264 T450 T451 det the,substrates
R265 T451 T449 pobj substrates,for
R267 T453 T451 prep of,substrates
R268 T454 T455 det these,enzymes
R269 T455 T453 pobj enzymes,of
R270 T456 T446 cc and,in
R271 T457 T446 conj in,in
R272 T458 T459 det the,design
R273 T459 T457 pobj design,in
R274 T460 T459 prep of,design
R275 T461 T462 amod more,inhibitors
R276 T462 T460 pobj inhibitors,of
R278 T464 T462 prep of,inhibitors
R279 T465 T464 pobj CLN2,of
R280 T466 T443 punct .,be
R70 T232 T227 amod ceroid,lipofuscinosis
R79 T243 T242 amod genomic,sequences
R87 T251 T250 amod systematic,analyses
R89 T253 T250 prep of,analyses
R90 T254 T255 poss their,distribution
R91 T255 T253 pobj distribution,of
R92 T256 T250 cc nor,analyses
R93 T257 T250 conj modeling,analyses
R94 T258 T257 prep of,modeling
R95 T259 T260 poss their,structures
R96 T260 T258 pobj structures,of
R97 T261 T252 aux have,attempted
R98 T262 T252 auxpass been,attempted
R99 T263 T252 advmod previously,attempted
R113 T281 T280 amod genomic,sequences
R149 T320 T321 punct ", ",distinct
R153 T324 T321 punct ", ",distinct
R165 T337 T336 advmod well,as
R175 T348 T349 advmod three,dimensional
R208 T388 T387 amod important,role
R212 T392 T391 compound life,cycles
R220 T402 T403 advmod very,open
R221 T403 T401 amod open,site
R222 T404 T403 cc and,open
R223 T405 T403 conj accessible,open
R224 T406 T401 amod active,site
R227 T409 T408 auxpass is,conserved
R228 T410 T411 advmod almost,completely
R229 T411 T408 advmod completely,conserved
R233 T415 T414 amod known,enzymes
R234 T416 T414 compound CLN2,enzymes
R245 T429 T430 det the,presence
R27 T186 T185 punct -,peptidase
R45 T205 T204 punct -,carboxyl
R61 T223 T222 amod fatal,disease
R62 T224 T222 amod neurodegenerative,disease
R66 T228 T229 amod late,infantile
R69 T231 T227 amod neuronal,lipofuscinosis
R246 T430 T428 nsubjpass presence,anticipated
R247 T431 T430 prep of,presence
R248 T432 T433 det a,pocket
R253 T437 T428 auxpass was,anticipated
R257 T442 T441 amod structural,model
R266 T452 T451 amod physiological,substrates
R277 T463 T462 amod specific,inhibitors