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PMC:2806624 / 2043-2625 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1391 0-1 DT denotes A
T1392 2-13 JJ denotes spontaneous
T1393 14-22 NN denotes mutation
T1394 23-25 IN denotes of
T1395 26-29 DT denotes the
T1396 30-49 NN denotes X-linked Foxp3 gene
T1397 50-64 NN denotes in scurfy mice
T1398 65-71 VB denotes causes
T1399 72-74 DT denotes an
T1400 75-90 JJ denotes autoimmune-like
T1401 91-98 NN denotes disease
T1402 98-99 -COMMA- denotes ,
T1403 100-107 IN denotes whereas
T1404 108-111 DT denotes the
T1405 112-120 NN denotes mutation
T1406 121-123 IN denotes in
T1407 124-130 NN denotes humans
T1408 131-136 VB denotes leads
T1409 137-139 TO denotes to
T1410 140-159 NN denotes immunodysregulation
T1411 159-160 -COMMA- denotes ,
T1412 161-179 NN denotes polyendocrinopathy
T1413 179-180 -COMMA- denotes ,
T1414 181-192 NN denotes enteropathy
T1415 192-193 -COMMA- denotes ,
T1416 194-197 CC denotes and
T1417 198-206 JJ denotes X-linked
T1418 207-215 NN denotes syndrome
T1419 216-220 WDT denotes that
T1420 221-223 VB denotes is
T1421 224-228 RB denotes also
T1422 229-230 DT denotes a
T1423 231-237 JJ denotes severe
T1424 238-248 JJ denotes multiorgan
T1425 249-259 JJ denotes autoimmune
T1426 260-267 NN denotes disease
T1427 268-272 IN denotes with
T1428 273-282 NN denotes hyper-IgE
T1429 283-284 -LRB- denotes (
T1430 284-291 NNP denotes Ziegler
T1431 291-292 -COMMA- denotes ,
T1432 293-297 CD denotes 2006
T1433 297-298 -RRB- denotes )
T1434 298-308 IN denotes . Although
T1435 309-312 DT denotes the
T1436 313-322 JJ denotes essential
T1437 323-327 NN denotes role
T1438 328-330 IN denotes of
T1439 331-336 NN denotes Foxp3
T1440 337-339 IN denotes in
T1441 340-347 JJ denotes central
T1442 348-351 CC denotes and
T1443 352-362 JJ denotes peripheral
T1444 363-372 NN denotes tolerance
T1445 373-376 VB denotes has
T1446 377-381 VB denotes been
T1447 382-393 RB denotes extensively
T1448 394-401 VB denotes studied
T1449 401-402 -COMMA- denotes ,
T1450 403-406 PRP-DOLLAR- denotes its
T1451 407-417 NN denotes regulation
T1452 417-418 -COMMA- denotes ,
T1453 419-430 NN denotes cooperation
T1454 431-435 IN denotes with
T1455 436-441 JJ denotes other
T1456 442-455 NN denotes transcription
T1457 456-463 NN denotes factors
T1458 463-464 -COMMA- denotes ,
T1459 465-468 CC denotes and
T1460 469-472 WRB denotes how
T1461 473-475 PRP denotes it
T1462 476-485 VB denotes functions
T1463 486-488 IN denotes in
T1464 489-498 JJ denotes inducible
T1465 499-500 NN denotes T
T1466 501-504 NN denotes reg
T1467 505-506 -LRB- denotes (
T1468 506-508 NN denotes iT
T1469 509-512 NN denotes reg
T1470 512-513 -RRB- denotes )
T1471 514-519 NN denotes cells
T1472 520-522 TO denotes to
T1473 523-531 VB denotes suppress
T1474 532-539 JJ denotes various
T1475 540-546 NN denotes target
T1476 547-552 NN denotes genes
T1477 553-555 VB denotes is
T1478 556-562 RB denotes mostly
T1479 563-566 RB denotes not
T1480 567-570 RB denotes yet
T1481 571-581 VB denotes understood
R973 T1393 T1391 arg1Of mutation,A
R974 T1393 T1392 arg1Of mutation,spontaneous
R975 T1393 T1394 arg1Of mutation,of
R976 T1393 T1398 arg1Of mutation,causes
R977 T1397 T1394 arg2Of in scurfy mice,of
R978 T1397 T1395 arg1Of in scurfy mice,the
R979 T1397 T1396 arg1Of in scurfy mice,X-linked Foxp3 gene
R980 T1398 T1403 arg1Of causes,whereas
R981 T1401 T1398 arg2Of disease,causes
R982 T1401 T1399 arg1Of disease,an
R983 T1401 T1400 arg1Of disease,autoimmune-like
R984 T1403 T1402 arg1Of whereas,","
R985 T1403 T1434 arg1Of whereas,". Although"
R986 T1405 T1404 arg1Of mutation,the
R987 T1405 T1406 arg1Of mutation,in
R988 T1405 T1408 arg1Of mutation,leads
R989 T1407 T1406 arg2Of humans,in
R990 T1408 T1403 arg2Of leads,whereas
R991 T1408 T1409 arg1Of leads,to
R992 T1410 T1411 arg1Of immunodysregulation,","
R993 T1411 T1413 arg1Of ",",","
R994 T1412 T1411 arg2Of polyendocrinopathy,","
R995 T1413 T1416 arg1Of ",",and
R996 T1414 T1413 arg2Of enteropathy,","
R997 T1416 T1409 arg2Of and,to
R998 T1416 T1415 arg1Of and,","
R999 T1418 T1416 arg2Of syndrome,and
R1000 T1418 T1417 arg1Of syndrome,X-linked
R1001 T1418 T1419 arg1Of syndrome,that
R1002 T1418 T1420 arg1Of syndrome,is
R1003 T1420 T1421 arg1Of is,also
R1004 T1420 T1429 arg1Of is,(
R1005 T1426 T1420 arg2Of disease,is
R1006 T1426 T1422 arg1Of disease,a
R1007 T1426 T1423 arg1Of disease,severe
R1008 T1426 T1424 arg1Of disease,multiorgan
R1009 T1426 T1425 arg1Of disease,autoimmune
R1010 T1426 T1427 arg1Of disease,with
R1011 T1428 T1427 arg2Of hyper-IgE,with
R1012 T1430 T1429 arg2Of Ziegler,(
R1013 T1430 T1431 arg1Of Ziegler,","
R1014 T1430 T1432 arg1Of Ziegler,2006
R1015 T1433 T1429 arg3Of ),(
R1016 T1437 T1435 arg1Of role,the
R1017 T1437 T1436 arg1Of role,essential
R1018 T1437 T1438 arg1Of role,of
R1019 T1437 T1440 arg1Of role,in
R1020 T1437 T1445 arg1Of role,has
R1021 T1437 T1446 arg1Of role,been
R1022 T1437 T1448 arg2Of role,studied
R1023 T1439 T1438 arg2Of Foxp3,of
R1024 T1441 T1442 arg1Of central,and
R1025 T1443 T1442 arg2Of peripheral,and
R1026 T1444 T1440 arg2Of tolerance,in
R1027 T1444 T1441 arg1Of tolerance,central
R1028 T1444 T1443 arg1Of tolerance,peripheral
R1029 T1448 T1445 arg2Of studied,has
R1030 T1448 T1446 arg2Of studied,been
R1031 T1448 T1447 arg1Of studied,extensively
R1032 T1448 T1449 arg1Of studied,","
R1033 T1449 T1434 arg2Of ",",". Although"
R1034 T1451 T1450 arg1Of regulation,its
R1035 T1451 T1452 arg1Of regulation,","
R1036 T1451 T1459 arg1Of regulation,and
R1037 T1453 T1452 arg2Of cooperation,","
R1038 T1453 T1454 arg1Of cooperation,with
R1039 T1457 T1454 arg2Of factors,with
R1040 T1457 T1455 arg1Of factors,other
R1041 T1457 T1456 arg1Of factors,transcription
R1042 T1459 T1458 arg1Of and,","
R1043 T1459 T1477 arg1Of and,is
R1044 T1459 T1481 arg2Of and,understood
R1045 T1460 T1459 arg2Of how,and
R1046 T1461 T1462 arg1Of it,functions
R1047 T1462 T1460 arg1Of functions,how
R1048 T1462 T1463 arg1Of functions,in
R1049 T1468 T1467 arg2Of iT,(
R1050 T1468 T1469 arg1Of iT,reg
R1051 T1470 T1467 arg3Of ),(
R1052 T1471 T1463 arg2Of cells,in
R1053 T1471 T1464 arg1Of cells,inducible
R1054 T1471 T1465 arg1Of cells,T
R1055 T1471 T1466 arg1Of cells,reg
R1056 T1471 T1467 arg1Of cells,(
R1057 T1471 T1472 modOf cells,to
R1058 T1473 T1472 arg1Of suppress,to
R1059 T1476 T1473 arg2Of genes,suppress
R1060 T1476 T1474 arg1Of genes,various
R1061 T1476 T1475 arg1Of genes,target
R1062 T1481 T1449 arg2Of understood,","
R1063 T1481 T1477 arg2Of understood,is
R1064 T1481 T1478 arg1Of understood,mostly
R1065 T1481 T1479 arg1Of understood,not
R1066 T1481 T1480 arg1Of understood,yet

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T2035 403-406 Anaphor denotes its
T2036 331-336 Antecedent denotes Foxp3
R1615 T2035 T2036 boundBy its,Foxp3

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T2212 0-1 DT denotes A
T2213 2-13 JJ denotes spontaneous
T2214 14-22 NN denotes mutation
T2215 23-25 IN denotes of
T2216 26-29 DT denotes the
T2217 30-49 JJ denotes X-linked Foxp3 gene
T2218 50-64 NN denotes in scurfy mice
T2219 65-71 VBZ denotes causes
T2220 72-74 DT denotes an
T2221 75-90 JJ denotes autoimmune-like
T2222 91-98 NN denotes disease
T2223 98-99 , denotes ,
T2224 100-107 IN denotes whereas
T2225 108-111 DT denotes the
T2226 112-120 NN denotes mutation
T2227 121-123 IN denotes in
T2228 124-130 NNS denotes humans
T2229 131-136 VBZ denotes leads
T2230 137-139 TO denotes to
T2231 140-159 NN denotes immunodysregulation
T2232 159-160 , denotes ,
T2233 161-179 NN denotes polyendocrinopathy
T2234 179-180 , denotes ,
T2235 181-192 NN denotes enteropathy
T2236 192-193 , denotes ,
T2237 194-197 CC denotes and
T2238 198-206 JJ denotes X-linked
T2239 207-215 NN denotes syndrome
T2240 216-220 WDT denotes that
T2241 221-223 VBZ denotes is
T2242 224-228 RB denotes also
T2243 229-230 DT denotes a
T2244 231-237 JJ denotes severe
T2245 238-248 JJ denotes multiorgan
T2246 249-259 JJ denotes autoimmune
T2247 260-267 NN denotes disease
T2248 268-272 IN denotes with
T2249 273-282 NNP denotes hyper-IgE
T2250 283-284 -LRB- denotes (
T2251 284-291 NNP denotes Ziegler
T2252 291-292 , denotes ,
T2253 293-297 CD denotes 2006
T2254 297-298 -RRB- denotes )
T2255 298-299 . denotes .
T2256 300-308 IN denotes Although
T2257 309-312 DT denotes the
T2258 313-322 JJ denotes essential
T2259 323-327 NN denotes role
T2260 328-330 IN denotes of
T2261 331-336 NNP denotes Foxp3
T2262 337-339 IN denotes in
T2263 340-347 JJ denotes central
T2264 348-351 CC denotes and
T2265 352-362 JJ denotes peripheral
T2266 363-372 NN denotes tolerance
T2267 373-376 VBZ denotes has
T2268 377-381 VBN denotes been
T2269 382-393 RB denotes extensively
T2270 394-401 VBN denotes studied
T2271 401-402 , denotes ,
T2272 403-406 PRP$ denotes its
T2273 407-417 NN denotes regulation
T2274 417-418 , denotes ,
T2275 419-430 NN denotes cooperation
T2276 431-435 IN denotes with
T2277 436-441 JJ denotes other
T2278 442-455 NN denotes transcription
T2279 456-463 NNS denotes factors
T2280 463-464 , denotes ,
T2281 465-468 CC denotes and
T2282 469-472 WRB denotes how
T2283 473-475 PRP denotes it
T2284 476-485 NNS denotes functions
T2285 486-488 IN denotes in
T2286 489-498 JJ denotes inducible
T2287 499-500 NNP denotes T
T2288 501-504 NN denotes reg
T2289 505-506 -LRB- denotes (
T2290 506-508 NNP denotes iT
T2291 509-512 NN denotes reg
T2292 512-513 -RRB- denotes )
T2293 514-519 NNS denotes cells
T2294 520-522 TO denotes to
T2295 523-531 VB denotes suppress
T2296 532-539 JJ denotes various
T2297 540-546 NN denotes target
T2298 547-552 NNS denotes genes
T2299 553-555 VBZ denotes is
T2300 556-562 RB denotes mostly
T2301 563-566 RB denotes not
T2302 567-570 RB denotes yet
T2303 571-581 VBN denotes understood
T2304 581-582 . denotes .
R1683 T2246 T2247 amod autoimmune,disease
R1685 T2247 T2241 attr disease,is
R1689 T2248 T2247 prep with,disease
R1693 T2249 T2248 pobj hyper-IgE,with
R1696 T2250 T2251 punct (,Ziegler
R1700 T2251 T2249 appos Ziegler,hyper-IgE
R1704 T2252 T2251 punct ",",Ziegler
R1711 T2253 T2251 npadvmod 2006,Ziegler
R1716 T2254 T2251 punct ),Ziegler
R1721 T2255 T2219 punct .,causes
R1723 T2212 T2214 det A,mutation
R1724 T2256 T2270 mark Although,studied
R1725 T2213 T2214 amod spontaneous,mutation
R1726 T2214 T2219 nsubj mutation,causes
R1727 T2215 T2214 prep of,mutation
R1728 T2257 T2259 det the,role
R1729 T2216 T2218 det the,in scurfy mice
R1730 T2217 T2218 amod X-linked Foxp3 gene,in scurfy mice
R1731 T2218 T2215 pobj in scurfy mice,of
R1732 T2258 T2259 amod essential,role
R1733 T2219 T2219 ROOT causes,causes
R1734 T2220 T2222 det an,disease
R1735 T2221 T2222 amod autoimmune-like,disease
R1736 T2259 T2270 nsubjpass role,studied
R1737 T2222 T2219 dobj disease,causes
R1738 T2223 T2219 punct ",",causes
R1739 T2224 T2229 mark whereas,leads
R1740 T2225 T2226 det the,mutation
R1741 T2226 T2229 nsubj mutation,leads
R1742 T2227 T2226 prep in,mutation
R1743 T2228 T2227 pobj humans,in
R1744 T2260 T2259 prep of,role
R1745 T2229 T2219 advcl leads,causes
R1746 T2230 T2229 prep to,leads
R1747 T2231 T2230 pobj immunodysregulation,to
R1748 T2261 T2260 pobj Foxp3,of
R1749 T2232 T2231 punct ",",immunodysregulation
R1750 T2233 T2231 conj polyendocrinopathy,immunodysregulation
R1751 T2234 T2233 punct ",",polyendocrinopathy
R1752 T2262 T2259 prep in,role
R1753 T2235 T2233 conj enteropathy,polyendocrinopathy
R1754 T2236 T2235 punct ",",enteropathy
R1755 T2237 T2235 cc and,enteropathy
R1756 T2238 T2239 compound X-linked,syndrome
R1757 T2239 T2235 conj syndrome,enteropathy
R1758 T2240 T2241 nsubj that,is
R1759 T2263 T2266 amod central,tolerance
R1760 T2241 T2239 relcl is,syndrome
R1761 T2242 T2241 advmod also,is
R1762 T2243 T2247 det a,disease
R1763 T2264 T2263 cc and,central
R1764 T2244 T2247 amod severe,disease
R1765 T2265 T2263 conj peripheral,central
R1766 T2245 T2247 amod multiorgan,disease
R1767 T2266 T2262 pobj tolerance,in
R1768 T2267 T2270 aux has,studied
R1769 T2268 T2270 auxpass been,studied
R1770 T2269 T2270 advmod extensively,studied
R1771 T2270 T2295 advcl studied,suppress
R1774 T2271 T2295 punct ",",suppress
R1777 T2272 T2273 poss its,regulation
R1781 T2273 T2295 nsubj regulation,suppress
R1784 T2274 T2273 punct ",",regulation
R1787 T2275 T2273 conj cooperation,regulation
R1788 T2276 T2275 prep with,cooperation
R1789 T2277 T2279 amod other,factors
R1792 T2278 T2279 compound transcription,factors
R1795 T2279 T2276 pobj factors,with
R1799 T2280 T2275 punct ",",cooperation
R1803 T2281 T2275 cc and,cooperation
R1810 T2282 T2284 advmod how,functions
R1814 T2283 T2284 nsubj it,functions
R1818 T2284 T2275 conj functions,cooperation
R1823 T2285 T2284 prep in,functions
R1827 T2286 T2288 amod inducible,reg
R1830 T2287 T2288 compound T,reg
R1834 T2288 T2285 pobj reg,in
R1837 T2289 T2291 punct (,reg
R1842 T2290 T2291 compound iT,reg
R1843 T2291 T2288 appos reg,reg
R1844 T2292 T2291 punct ),reg
R1847 T2293 T2284 conj cells,functions
R1849 T2294 T2295 aux to,suppress
R1852 T2295 T2295 ROOT suppress,suppress
R1860 T2296 T2298 amod various,genes
R1867 T2297 T2298 compound target,genes
R1870 T2298 T2295 dobj genes,suppress
R1874 T2299 T2303 auxpass is,understood
R1878 T2300 T2303 advmod mostly,understood
R1882 T2301 T2303 neg not,understood
R1885 T2302 T2303 advmod yet,understood
R1889 T2303 T2295 advcl understood,suppress
R1893 T2304 T2295 punct .,suppress

UBERON-AE

Id Subject Object Predicate Lexical cue
T1193 340-347 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T1194 382-393 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively

GO-BP

Id Subject Object Predicate Lexical cue
T2970 442-455 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T2981 407-417 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

GO-CC

Id Subject Object Predicate Lexical cue
T3009 514-519 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T1279 0-582 Sentence denotes A spontaneous mutation of the X-linked Foxp3 gene in scurfy mice causes an autoimmune-like disease, whereas the mutation in humans leads to immunodysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome that is also a severe multiorgan autoimmune disease with hyper-IgE (Ziegler, 2006). Although the essential role of Foxp3 in central and peripheral tolerance has been extensively studied, its regulation, cooperation with other transcription factors, and how it functions in inducible T reg (iT reg) cells to suppress various target genes is mostly not yet understood.
T14 0-299 Sentence denotes A spontaneous mutation of the X-linked Foxp3 gene in scurfy mice causes an autoimmune-like disease, whereas the mutation in humans leads to immunodysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome that is also a severe multiorgan autoimmune disease with hyper-IgE (Ziegler, 2006).
T15 300-582 Sentence denotes Although the essential role of Foxp3 in central and peripheral tolerance has been extensively studied, its regulation, cooperation with other transcription factors, and how it functions in inducible T reg (iT reg) cells to suppress various target genes is mostly not yet understood.

events-check-again

Id Subject Object Predicate Lexical cue
T3212 39-44 Protein denotes Foxp3
T3213 331-336 Protein denotes Foxp3
T3214 407-417 Regulation denotes regulation
R2498 T3213 T3214 themeOf Foxp3,regulation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T3033 30-49 Protein denotes X-linked Foxp3 gene
T3034 331-336 Protein denotes Foxp3
T3035 499-504 Protein denotes T reg
T3036 506-512 Protein denotes iT reg
T3037 407-417 Regulation denotes regulation
T3038 489-498 Positive_regulation denotes inducible
T3039 489-498 Positive_regulation denotes inducible
R2445 T3034 T3037 themeOf Foxp3,regulation
R2446 T3035 T3038 themeOf T reg,inducible
R2448 T3036 T3039 themeOf iT reg,inducible

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T1202 39-44 Protein denotes Foxp3
T1203 331-336 Protein denotes Foxp3
T1204 407-417 Regulation denotes regulation
R831 T1203 T1204 themeOf Foxp3,regulation

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T2040 331-336 Q9BZS1 denotes Foxp3

test2

Id Subject Object Predicate Lexical cue
T1120 32-49 Protein denotes linked Foxp3 gene
T1121 323-327 Regulation denotes role
T1122 331-336 Protein denotes Foxp3