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2. RUNX1 and RUNX3 expression in Foxp3+ T reg cells and in human CD4+, CD127−, CD25high cells. (A) Real-time PCR analysis of CD4+, CD127−, and CD25high T reg cells and CD4+, CD127+, and CD25neg T cells isolated from human peripheral blood showed an increased expression of IL-10, TGF-β, FOXP3, and RUNX3 mRNA in CD25+ compared with CD25− cells. Bars show the mean ± SE of three independent experiments. (B) Human tonsil sections were analyzed by confocal microscopy. Tissue sections were stained for FOXP3, RUNX1, RUNX3, and DAPI or isotype controls. HEK cells RUNX1-transfected or not transfected served as additional control for RUNX1 staining. Data shown are representative from one of the three tissue samples with similar results. Bars, 5 µm. Statistical differences were verified by the paired Student's t test. *, P \u003c 0.05; **, P \u003c 0.01.\n\n"}

{"project":"UBERON-AE","denotations":[{"id":"T29664","span":{"begin":241,"end":246},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T29665","span":{"begin":421,"end":427},"obj":"http://purl.obolibrary.org/obo/UBERON_0002372"},{"id":"T29666","span":{"begin":707,"end":713},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Figure 2. RUNX1 and RUNX3 expression in Foxp3+ T reg cells and in human CD4+, CD127−, CD25high cells. (A) Real-time PCR analysis of CD4+, CD127−, and CD25high T reg cells and CD4+, CD127+, and CD25neg T cells isolated from human peripheral blood showed an increased expression of IL-10, TGF-β, FOXP3, and RUNX3 mRNA in CD25+ compared with CD25− cells. Bars show the mean ± SE of three independent experiments. (B) Human tonsil sections were analyzed by confocal microscopy. Tissue sections were stained for FOXP3, RUNX1, RUNX3, and DAPI or isotype controls. HEK cells RUNX1-transfected or not transfected served as additional control for RUNX1 staining. Data shown are representative from one of the three tissue samples with similar results. Bars, 5 µm. Statistical differences were verified by the paired Student's t test. *, P \u003c 0.05; **, P \u003c 0.01.\n\n"}

{"project":"GO-MF","denotations":[{"id":"T30108","span":{"begin":281,"end":286},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"Figure 2. RUNX1 and RUNX3 expression in Foxp3+ T reg cells and in human CD4+, CD127−, CD25high cells. (A) Real-time PCR analysis of CD4+, CD127−, and CD25high T reg cells and CD4+, CD127+, and CD25neg T cells isolated from human peripheral blood showed an increased expression of IL-10, TGF-β, FOXP3, and RUNX3 mRNA in CD25+ compared with CD25− cells. Bars show the mean ± SE of three independent experiments. (B) Human tonsil sections were analyzed by confocal microscopy. Tissue sections were stained for FOXP3, RUNX1, RUNX3, and DAPI or isotype controls. HEK cells RUNX1-transfected or not transfected served as additional control for RUNX1 staining. Data shown are representative from one of the three tissue samples with similar results. Bars, 5 µm. Statistical differences were verified by the paired Student's t test. *, P \u003c 0.05; **, P \u003c 0.01.\n\n"}

{"project":"GO-CC","denotations":[{"id":"T30109","span":{"begin":54,"end":59},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T30110","span":{"begin":96,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T30111","span":{"begin":166,"end":171},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T30112","span":{"begin":204,"end":209},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T30113","span":{"begin":346,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T30114","span":{"begin":563,"end":568},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Figure 2. RUNX1 and RUNX3 expression in Foxp3+ T reg cells and in human CD4+, CD127−, CD25high cells. (A) Real-time PCR analysis of CD4+, CD127−, and CD25high T reg cells and CD4+, CD127+, and CD25neg T cells isolated from human peripheral blood showed an increased expression of IL-10, TGF-β, FOXP3, and RUNX3 mRNA in CD25+ compared with CD25− cells. Bars show the mean ± SE of three independent experiments. (B) Human tonsil sections were analyzed by confocal microscopy. Tissue sections were stained for FOXP3, RUNX1, RUNX3, and DAPI or isotype controls. HEK cells RUNX1-transfected or not transfected served as additional control for RUNX1 staining. Data shown are representative from one of the three tissue samples with similar results. Bars, 5 µm. Statistical differences were verified by the paired Student's t test. *, P \u003c 0.05; **, P \u003c 0.01.\n\n"}

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