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PMC:2800179 / 29490-38613 JSONTXT

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ICD10

Id Subject Object Predicate Lexical cue
T15083 5737-5752 http://purl.bioontology.org/ontology/ICD10/K50.9 denotes Crohn's disease
T15084 5979-5994 http://purl.bioontology.org/ontology/ICD10/K50.9 denotes Crohn's disease
T15085 6187-6202 http://purl.bioontology.org/ontology/ICD10/K50.9 denotes Crohn's disease
T15086 7963-7978 http://purl.bioontology.org/ontology/ICD10/K50.9 denotes Crohn's disease
T15087 5838-5856 http://purl.bioontology.org/ontology/ICD10/K51 denotes ulcerative colitis
T15088 5838-5856 http://purl.bioontology.org/ontology/ICD10/K51.9 denotes ulcerative colitis

GO-CC

Id Subject Object Predicate Lexical cue
T15089 232-237 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15090 2521-2526 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15091 2662-2667 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15092 2782-2787 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15093 3100-3105 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15094 3925-3930 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15095 4036-4041 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15096 4288-4293 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15097 4538-4543 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15098 4857-4862 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15099 5292-5297 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15100 5414-5419 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15101 5708-5713 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15102 5771-5776 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15103 6931-6936 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15104 7246-7251 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15105 8669-8674 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15106 8698-8702 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15107 4667-4675 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T15108 4667-4675 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T15109 4803-4811 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T15110 6554-6561 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus

GO-MF

Id Subject Object Predicate Lexical cue
T15080 2882-2885 http://purl.obolibrary.org/obo/GO_0004601 denotes MPO
T15081 4667-4675 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T15082 5023-5030 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-BP

Id Subject Object Predicate Lexical cue
T14987 11-23 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T14988 276-288 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14989 431-443 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14990 599-611 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14991 1719-1731 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14992 1849-1861 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14993 2099-2111 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14994 2224-2236 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14995 2299-2311 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14996 8127-8139 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T14997 174-190 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T14998 213-237 http://purl.obolibrary.org/obo/GO_0030154 denotes differentiate into cells
T14999 469-478 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15000 783-792 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15001 4150-4159 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15002 4513-4522 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15003 4733-4742 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15004 4940-4949 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15005 8834-8843 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T15006 658-678 http://purl.obolibrary.org/obo/GO_0045321 denotes leukocyte activation
T15007 3475-3495 http://purl.obolibrary.org/obo/GO_0045321 denotes leukocyte activation
T15008 764-792 http://purl.obolibrary.org/obo/GO_0050715 denotes stimulate cytokine secretion
T15009 774-792 http://purl.obolibrary.org/obo/GO_0050663 denotes cytokine secretion
T15010 4931-4949 http://purl.obolibrary.org/obo/GO_0050663 denotes cytokine secretion
T15011 877-886 http://purl.obolibrary.org/obo/GO_0051923 denotes sulphated
T15012 1169-1177 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15013 1281-1289 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15014 3545-3553 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15015 5561-5569 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15016 6013-6021 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15017 6756-6764 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15018 9026-9034 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T15019 1590-1599 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T15020 2365-2383 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T15021 2722-2740 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T15022 7108-7126 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T15023 8623-8641 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T15024 2413-2436 http://purl.obolibrary.org/obo/GO_0061516 denotes monocytes proliferation
T15025 2882-2885 http://purl.obolibrary.org/obo/GO_0004601 denotes MPO
T15026 2989-3016 http://purl.obolibrary.org/obo/GO_0042116 denotes activation into macrophages
T15027 3060-3077 http://purl.obolibrary.org/obo/GO_0032640 denotes production of TNF
T15028 3157-3174 http://purl.obolibrary.org/obo/GO_0032640 denotes production of TNF
T15029 7805-7821 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF-α production
T15030 3304-3323 http://purl.obolibrary.org/obo/GO_0042117 denotes monocyte activation
T15031 3715-3734 http://purl.obolibrary.org/obo/GO_0042117 denotes monocyte activation
T15032 5340-5359 http://purl.obolibrary.org/obo/GO_0042117 denotes activated monocytes
T15033 6038-6056 http://purl.obolibrary.org/obo/GO_0042117 denotes activate monocytes
T15034 3582-3590 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T15035 8493-8501 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T15036 4066-4081 http://purl.obolibrary.org/obo/GO_0032496 denotes response to LPS
T15037 4146-4159 http://purl.obolibrary.org/obo/GO_1990774 denotes TNF secretion
T15038 4509-4522 http://purl.obolibrary.org/obo/GO_1990774 denotes TNF secretion
T15039 4729-4742 http://purl.obolibrary.org/obo/GO_1990774 denotes TNF secretion
T15040 4173-4185 http://purl.obolibrary.org/obo/GO_0034612 denotes TNF response
T15041 6249-6258 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T15042 7891-7900 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T15043 6350-6366 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15044 6458-6474 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15045 7289-7305 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15046 7393-7409 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15047 8928-8944 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T15048 7013-7024 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T15049 7018-7024 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T15050 7433-7439 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T15051 7080-7096 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T15052 7180-7201 http://purl.obolibrary.org/obo/GO_0051726 denotes cell cycle regulation
T15053 7165-7184 http://purl.obolibrary.org/obo/GO_0001775 denotes activation and cell
T15054 7165-7190 http://purl.obolibrary.org/obo/GO_1901978 denotes activation and cell cycle
T15055 7165-7190 http://purl.obolibrary.org/obo/GO_1901989 denotes activation and cell cycle
T15056 7165-7190 http://purl.obolibrary.org/obo/GO_1901995 denotes activation and cell cycle
T15057 7165-7190 http://purl.obolibrary.org/obo/GO_1903452 denotes activation and cell cycle
T15058 7180-7190 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T15059 8698-8708 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T15060 7180-7201 http://purl.obolibrary.org/obo/GO_0051445 denotes cell cycle regulation
T15061 7180-7201 http://purl.obolibrary.org/obo/GO_1901976 denotes cell cycle regulation
T15062 7180-7201 http://purl.obolibrary.org/obo/GO_0010564 denotes cell cycle regulation
T15063 7180-7201 http://purl.obolibrary.org/obo/GO_0032465 denotes cell cycle regulation
T15064 7180-7201 http://purl.obolibrary.org/obo/GO_0045787 denotes cell cycle regulation
T15065 7180-7201 http://purl.obolibrary.org/obo/GO_0007346 denotes cell cycle regulation
T15066 7180-7201 http://purl.obolibrary.org/obo/GO_0045786 denotes cell cycle regulation
T15067 7180-7201 http://purl.obolibrary.org/obo/GO_0071156 denotes cell cycle regulation
T15068 7191-7201 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T15069 7805-7821 http://purl.obolibrary.org/obo/GO_0032680 denotes TNF-α production
T15070 8544-8570 http://purl.obolibrary.org/obo/GO_0061582 denotes intestinal epithelial cell
T15071 8544-8570 http://purl.obolibrary.org/obo/GO_0060574 denotes intestinal epithelial cell
T15072 8544-8570 http://purl.obolibrary.org/obo/GO_0060575 denotes intestinal epithelial cell
T15073 8544-8570 http://purl.obolibrary.org/obo/GO_0060576 denotes intestinal epithelial cell
T15074 8682-8690 http://purl.obolibrary.org/obo/GO_0051318 denotes G1 phase
T15075 8685-8708 http://purl.obolibrary.org/obo/GO_0098763 denotes phase of the cell cycle
T15076 8685-8708 http://purl.obolibrary.org/obo/GO_0022403 denotes phase of the cell cycle
T15077 8685-8708 http://purl.obolibrary.org/obo/GO_0044770 denotes phase of the cell cycle
T15078 8685-8708 http://purl.obolibrary.org/obo/GO_0098762 denotes phase of the cell cycle
T15079 8767-8787 http://purl.obolibrary.org/obo/GO_0070487 denotes monocyte aggregation

2_test

Id Subject Object Predicate Lexical cue
20072622-9136827-93233370 130-132 9136827 denotes 17
20072622-12167685-93233371 510-512 12167685 denotes 33
20072622-11581570-93233372 715-717 11581570 denotes 34
20072622-12213727-93233373 824-826 12213727 denotes 36
20072622-17034924-93233374 1161-1162 17034924 denotes 8
20072622-2570843-93233375 1271-1272 2570843 denotes 5
20072622-3943102-93233376 1340-1341 3943102 denotes 4
20072622-11675262-93233377 1345-1346 11675262 denotes 6
20072622-17034924-93233378 1349-1350 17034924 denotes 8
20072622-8849638-93233379 1651-1653 8849638 denotes 11
20072622-9178362-93233380 1657-1659 9178362 denotes 12
20072622-8741008-93233381 2113-2115 8741008 denotes 20
20072622-18287351-93233382 2582-2584 18287351 denotes 37
20072622-18304834-93233383 3811-3813 18304834 denotes 40
20072622-18252714-93233384 4864-4866 18252714 denotes 41
20072622-8819222-93233385 5754-5756 8819222 denotes 42
20072622-8819222-93233386 5858-5860 8819222 denotes 42
20072622-7680015-93233387 5996-5998 7680015 denotes 43
20072622-9438323-93233388 6002-6004 9438323 denotes 44
20072622-8527703-93233389 6260-6262 8527703 denotes 45
20072622-2966248-93233390 6266-6268 2966248 denotes 46
20072622-10712233-93233391 6432-6434 10712233 denotes 47
20072622-2460392-93233392 6938-6940 2460392 denotes 48
20072622-16410803-93233393 7128-7130 16410803 denotes 49
20072622-12571598-93233394 7253-7255 12571598 denotes 50
20072622-12612054-93233395 7525-7527 12612054 denotes 51
20072622-2460392-93233396 8582-8584 2460392 denotes 48

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T11641 11-23 NN denotes Inflammation
T11642 24-26 IN denotes of
T11643 27-30 DT denotes the
T11644 31-41 JJ denotes intestinal
T11645 42-47 NN denotes tract
T11646 48-50 VB denotes is
T11647 51-58 RB denotes usually
T11648 59-69 VB denotes associated
T11649 70-74 IN denotes with
T11650 75-87 NN denotes infiltration
T11651 88-91 CC denotes and
T11652 92-102 NN denotes activation
T11653 103-105 IN denotes of
T11654 106-116 JJ denotes intestinal
T11655 117-128 NN denotes macrophages
T11656 129-130 -LRB- denotes [
T11657 130-132 CD denotes 17
T11658 132-133 -RRB- denotes ]
T11659 135-140 DT denotes These
T11660 141-152 NN denotes macrophages
T11661 153-156 VB denotes are
T11662 157-161 JJ denotes able
T11663 162-164 TO denotes to
T11664 165-173 VB denotes initiate
T11665 174-180 JJ denotes immune
T11666 181-190 NN denotes responses
T11667 191-194 CC denotes and
T11668 195-198 MD denotes can
T11669 199-201 VB denotes be
T11670 202-209 VB denotes induced
T11671 210-212 TO denotes to
T11672 213-226 VB denotes differentiate
T11673 227-231 IN denotes into
T11674 232-237 NN denotes cells
T11675 238-242 IN denotes that
T11676 243-249 CC denotes either
T11677 250-260 NN denotes exacerbate
T11678 261-263 CC denotes or
T11679 264-271 VB denotes inhibit
T11680 272-275 DT denotes the
T11681 276-288 NN denotes inflammation
T11682 290-302 NN denotes Accumulation
T11683 303-305 IN denotes of
T11684 306-315 JJ denotes different
T11685 316-321 NN denotes types
T11686 322-324 IN denotes of
T11687 325-335 NN denotes leukocytes
T11688 335-336 -COMMA- denotes ,
T11689 337-346 VB denotes including
T11690 347-368 NN denotes monocytes/macrophages
T11691 368-369 -COMMA- denotes ,
T11692 370-381 NN denotes neutrophils
T11693 381-382 -COMMA- denotes ,
T11694 383-386 CC denotes and
T11695 387-398 NN denotes lymphocytes
T11696 399-401 IN denotes in
T11697 402-405 DT denotes the
T11698 406-416 JJ denotes intestinal
T11699 417-423 NN denotes mucosa
T11700 424-430 IN denotes during
T11701 431-443 NN denotes inflammation
T11702 443-444 -COMMA- denotes ,
T11703 445-447 VB denotes is
T11704 448-456 RB denotes normally
T11705 457-465 VB denotes followed
T11706 466-468 IN denotes by
T11707 469-478 NN denotes secretion
T11708 479-481 IN denotes of
T11709 482-498 JJ denotes pro-inflammatory
T11710 499-508 NN denotes cytokines
T11711 509-510 -LRB- denotes [
T11712 510-512 CD denotes 33
T11713 512-513 -RRB- denotes ]
T11714 515-522 JJ denotes Several
T11715 523-530 NN denotes stimuli
T11716 531-534 MD denotes can
T11717 535-541 VB denotes induce
T11718 542-547 DT denotes these
T11719 548-558 NN denotes leukocytes
T11720 559-561 TO denotes to
T11721 562-569 VB denotes produce
T11722 570-573 CC denotes and
T11723 574-581 JJ denotes secrete
T11724 582-591 NN denotes cytokines
T11725 592-598 IN denotes during
T11726 599-611 NN denotes inflammation
T11727 613-616 CD denotes One
T11728 617-619 IN denotes of
T11729 620-623 DT denotes the
T11730 624-628 RB denotes most
T11731 629-635 JJ denotes potent
T11732 636-639 CC denotes and
T11733 640-645 VB denotes known
T11734 646-653 NN denotes stimuli
T11735 654-657 IN denotes for
T11736 658-667 NN denotes leukocyte
T11737 668-678 NN denotes activation
T11738 679-681 VB denotes is
T11739 682-685 NN denotes LPS
T11740 686-690 IN denotes from
T11741 691-704 JJ denotes Gram-negative
T11742 705-713 NN denotes bacteria
T11743 714-715 -LRB- denotes [
T11744 715-717 CD denotes 34
T11745 717-718 -RRB- denotes ]
T11746 720-722 IN denotes In
T11747 723-731 NN denotes addition
T11748 731-732 -COMMA- denotes ,
T11749 733-738 JJ denotes other
T11750 739-746 NN denotes factors
T11751 747-750 VB denotes are
T11752 751-755 RB denotes also
T11753 756-760 JJ denotes able
T11754 761-763 TO denotes to
T11755 764-773 VB denotes stimulate
T11756 774-782 NN denotes cytokine
T11757 783-792 NN denotes secretion
T11758 793-797 IN denotes from
T11759 798-805 JJ denotes various
T11760 806-816 NN denotes leukocytes
T11761 817-818 -LRB- denotes [
T11762 818-820 CD denotes 35
T11763 820-821 -RRB- denotes ]
T11764 821-822 -COMMA- denotes ,
T11765 823-824 -LRB- denotes [
T11766 824-826 CD denotes 36
T11767 826-827 -RRB- denotes ]
T11768 829-832 CD denotes One
T11769 833-837 JJ denotes such
T11770 838-844 NN denotes factor
T11771 845-847 VB denotes is
T11772 848-851 NN denotes CGN
T11773 851-852 -COMMA- denotes ,
T11774 853-854 DT denotes a
T11775 855-859 JJ denotes high
T11776 860-869 JJ denotes molecular
T11777 870-876 NN denotes weight
T11778 877-886 VB denotes sulphated
T11779 887-901 NN denotes polysaccharide
T11780 902-903 -LRB- denotes (
T11781 903-904 SYM denotes >
T11782 904-907 CD denotes 200
T11783 908-911 NN denotes kDa
T11784 911-912 -RRB- denotes )
T11785 913-920 VB denotes derived
T11786 921-925 IN denotes from
T11787 926-929 JJ denotes red
T11788 930-935 NN denotes algae
T11789 936-937 -LRB- denotes (
T11790 937-949 NNP denotes Rhodophyceae
T11791 949-950 -RRB- denotes )
T11792 951-952 -LRB- denotes [
T11793 952-953 CD denotes 1
T11794 953-954 -RRB- denotes ]
T11795 954-955 -COMMA- denotes ,
T11796 956-957 -LRB- denotes [
T11797 957-958 CD denotes 2
T11798 958-959 -RRB- denotes ]
T11799 961-967 JJ denotes Native
T11800 968-971 NN denotes CGN
T11801 972-974 VB denotes is
T11802 975-981 RB denotes widely
T11803 982-986 VB denotes used
T11804 987-989 IN denotes as
T11805 990-991 DT denotes a
T11806 992-996 NN denotes food
T11807 997-1005 JJ denotes additive
T11808 1006-1007 -LRB- denotes (
T11809 1007-1008 NN denotes E
T11810 1009-1012 CD denotes 407
T11811 1012-1013 -RRB- denotes )
T11812 1014-1016 TO denotes to
T11813 1017-1024 VB denotes improve
T11814 1025-1032 NN denotes texture
T11815 1034-1036 PRP denotes It
T11816 1037-1039 VB denotes is
T11817 1040-1044 RB denotes also
T11818 1045-1049 VB denotes used
T11819 1050-1052 IN denotes in
T11820 1053-1062 NN denotes cosmetics
T11821 1063-1066 CC denotes and
T11822 1067-1082 NN denotes pharmaceuticals
T11823 1084-1092 IN denotes Although
T11824 1093-1099 JJ denotes native
T11825 1100-1104 NN denotes form
T11826 1105-1108 NN denotes CGN
T11827 1109-1110 -LRB- denotes (
T11828 1110-1117 CD denotes 200–800
T11829 1118-1121 NN denotes kDa
T11830 1121-1122 -RRB- denotes )
T11831 1123-1126 VB denotes has
T11832 1127-1131 VB denotes been
T11833 1132-1140 VB denotes declared
T11834 1141-1149 JJ denotes harmless
T11835 1150-1152 TO denotes to
T11836 1153-1159 NN denotes humans
T11837 1160-1161 -LRB- denotes [
T11838 1161-1162 CD denotes 8
T11839 1162-1163 -RRB- denotes ]
T11840 1163-1164 -COMMA- denotes ,
T11841 1165-1168 PRP-DOLLAR- denotes its
T11842 1169-1177 JJ denotes degraded
T11843 1178-1183 NN denotes forms
T11844 1184-1185 -LRB- denotes (
T11845 1185-1186 SYM denotes <
T11846 1186-1188 CD denotes 50
T11847 1189-1192 NN denotes kDa
T11848 1192-1193 -RRB- denotes )
T11849 1193-1194 -COMMA- denotes ,
T11850 1195-1199 RB denotes also
T11851 1200-1205 VB denotes known
T11852 1206-1208 IN denotes as
T11853 1209-1219 NN denotes poligeenan
T11854 1219-1220 -COMMA- denotes ,
T11855 1221-1224 VB denotes are
T11856 1225-1231 RB denotes widely
T11857 1232-1236 VB denotes used
T11858 1237-1239 TO denotes to
T11859 1240-1246 VB denotes induce
T11860 1247-1254 NN denotes colitis
T11861 1255-1257 IN denotes in
T11862 1258-1265 NN denotes rodents
T11863 1266-1267 -LRB- denotes [
T11864 1267-1268 CD denotes 3
T11865 1268-1269 -RRB- denotes ]
T11866 1269-1270 CD denotes –
T11867 1270-1271 -LRB- denotes [
T11868 1271-1272 CD denotes 5
T11869 1272-1273 -RRB- denotes ]
T11870 1275-1280 DT denotes These
T11871 1281-1289 VB denotes degraded
T11872 1290-1293 NN denotes CGN
T11873 1294-1297 MD denotes may
T11874 1298-1302 RB denotes also
T11875 1303-1307 VB denotes have
T11876 1308-1309 DT denotes a
T11877 1310-1318 JJ denotes possible
T11878 1319-1331 JJ denotes carcinogenic
T11879 1332-1338 NN denotes effect
T11880 1339-1340 -LRB- denotes [
T11881 1340-1341 CD denotes 4
T11882 1341-1342 -RRB- denotes ]
T11883 1342-1343 -COMMA- denotes ,
T11884 1344-1345 -LRB- denotes [
T11885 1345-1346 CD denotes 6
T11886 1346-1347 -RRB- denotes ]
T11887 1347-1348 -LRB- denotes –
T11888 1348-1349 CD denotes [
T11889 1349-1350 -RRB- denotes 8
T11890 1350-1351 -COLON- denotes ]
T11891 1351-1358 RB denotes ; howev
T11892 1358-1362 DT denotes er t
T11893 1362-1364 VB denotes hi
T11894 1364-1369 RB denotes s is
T11895 1369-1382 JJ denotes still controv
T11896 1390-1398 IN denotes Although
T11897 1399-1403 NN denotes acid
T11898 1404-1413 NN denotes treatment
T11899 1414-1416 IN denotes at
T11900 1417-1421 JJ denotes high
T11901 1422-1433 NN denotes temperature
T11902 1434-1435 -LRB- denotes (
T11903 1435-1439 NN denotes 80°C
T11904 1439-1440 -RRB- denotes )
T11905 1441-1443 VB denotes is
T11906 1444-1452 VB denotes required
T11907 1453-1456 IN denotes for
T11908 1457-1460 NN denotes CGN
T11909 1461-1471 NN denotes hydrolysis
T11910 1472-1474 FW denotes in
T11911 1475-1480 FW denotes vitro
T11912 1481-1483 TO denotes to
T11913 1484-1489 VB denotes lower
T11914 1490-1499 JJ denotes molecular
T11915 1500-1506 NN denotes weight
T11916 1507-1511 NN denotes dCGN
T11917 1511-1512 -COMMA- denotes ,
T11918 1513-1515 PRP denotes it
T11919 1516-1518 VB denotes is
T11920 1519-1527 JJ denotes probable
T11921 1528-1532 IN denotes that
T11922 1533-1537 DT denotes some
T11923 1538-1542 NN denotes dCGN
T11924 1543-1546 VB denotes are
T11925 1547-1555 VB denotes produced
T11926 1556-1558 IN denotes by
T11927 1559-1563 NN denotes acid
T11928 1564-1574 NN denotes hydrolysis
T11929 1575-1581 IN denotes during
T11930 1582-1589 JJ denotes gastric
T11931 1590-1599 NN denotes digestion
T11932 1600-1601 -LRB- denotes [
T11933 1601-1602 CD denotes 9
T11934 1602-1603 -RRB- denotes ]
T11935 1603-1604 -COMMA- denotes ,
T11936 1605-1606 -LRB- denotes [
T11937 1606-1608 CD denotes 10
T11938 1608-1609 -RRB- denotes ]
T11939 1610-1612 CC denotes or
T11940 1613-1624 NN denotes interaction
T11941 1625-1629 IN denotes with
T11942 1630-1640 JJ denotes intestinal
T11943 1641-1649 NN denotes bacteria
T11944 1650-1651 -LRB- denotes [
T11945 1651-1653 CD denotes 11
T11946 1653-1654 -RRB- denotes ]
T11947 1654-1655 -COMMA- denotes ,
T11948 1656-1657 -LRB- denotes [
T11949 1657-1659 CD denotes 12
T11950 1659-1660 -RRB- denotes ]
T11951 1662-1666 RB denotes Thus
T11952 1666-1667 -COMMA- denotes ,
T11953 1668-1681 VB denotes understanding
T11954 1682-1685 DT denotes the
T11955 1686-1696 NN denotes mechanisms
T11956 1697-1699 IN denotes of
T11957 1700-1712 JJ denotes dCGN-induced
T11958 1713-1718 NN denotes bowel
T11959 1719-1731 NN denotes inflammation
T11960 1732-1734 VB denotes is
T11961 1735-1737 IN denotes of
T11962 1738-1743 JJ denotes great
T11963 1744-1754 NN denotes importance
T11964 1756-1758 IN denotes In
T11965 1759-1763 DT denotes this
T11966 1764-1770 NN denotes report
T11967 1770-1771 -COMMA- denotes ,
T11968 1772-1774 PRP denotes we
T11969 1775-1779 VB denotes have
T11970 1780-1788 VB denotes analyzed
T11971 1789-1792 DT denotes the
T11972 1793-1797 NN denotes role
T11973 1798-1800 IN denotes of
T11974 1801-1806 JJ denotes human
T11975 1807-1816 NN denotes monocytes
T11976 1817-1818 -LRB- denotes (
T11977 1818-1821 NN denotes PBM
T11978 1822-1825 CC denotes and
T11979 1826-1831 NN denotes THP-1
T11980 1831-1832 -RRB- denotes )
T11981 1833-1835 IN denotes in
T11982 1836-1848 JJ denotes dCGN-induced
T11983 1849-1861 NN denotes inflammation
T11984 1863-1874 JJ denotes Preliminary
T11985 1875-1877 FW denotes in
T11986 1878-1882 FW denotes vivo
T11987 1883-1890 NN denotes studies
T11988 1891-1893 IN denotes in
T11989 1894-1898 NN denotes rats
T11990 1899-1906 VB denotes treated
T11991 1907-1911 IN denotes with
T11992 1912-1916 NN denotes dCGN
T11993 1917-1925 VB denotes revealed
T11994 1926-1937 JJ denotes significant
T11995 1938-1948 NN denotes shortening
T11996 1949-1951 IN denotes of
T11997 1952-1955 DT denotes the
T11998 1956-1961 JJ denotes large
T11999 1962-1971 NN denotes intestine
T12000 1972-1982 VB denotes associated
T12001 1983-1987 IN denotes with
T12002 1988-1990 DT denotes an
T12003 1991-2003 JJ denotes inflammatory
T12004 2004-2009 NN denotes state
T12005 2009-2010 -COMMA- denotes ,
T12006 2011-2015 FW denotes i.e.
T12007 2016-2022 JJ denotes strong
T12008 2023-2035 NN denotes infiltration
T12009 2036-2038 IN denotes of
T12010 2039-2050 NN denotes macrophages
T12011 2051-2053 TO denotes to
T12012 2054-2057 DT denotes the
T12013 2058-2068 JJ denotes intestinal
T12014 2069-2075 NN denotes mucosa
T12015 2076-2083 JJ denotes similar
T12016 2084-2086 TO denotes to
T12017 2087-2098 JJ denotes DSS-induced
T12018 2099-2111 NN denotes inflammation
T12019 2112-2113 -LRB- denotes [
T12020 2113-2115 CD denotes 20
T12021 2115-2116 -RRB- denotes ]
T12022 2118-2123 VB denotes Using
T12023 2124-2127 CD denotes two
T12024 2128-2137 NN denotes fractions
T12025 2138-2140 IN denotes of
T12026 2141-2145 NN denotes dCGN
T12027 2146-2147 -LRB- denotes (
T12028 2147-2149 CD denotes 10
T12029 2150-2153 CC denotes and
T12030 2154-2156 CD denotes 40
T12031 2157-2160 NN denotes kDa
T12032 2160-2161 -RRB- denotes )
T12033 2161-2162 -COMMA- denotes ,
T12034 2163-2165 PRP denotes we
T12035 2166-2174 VB denotes observed
T12036 2175-2176 DT denotes a
T12037 2177-2183 JJ denotes strong
T12038 2184-2195 NN denotes correlation
T12039 2196-2203 IN denotes between
T12040 2204-2207 DT denotes the
T12041 2208-2216 NN denotes severity
T12042 2217-2219 IN denotes of
T12043 2220-2223 DT denotes the
T12044 2224-2236 NN denotes inflammation
T12045 2237-2240 CC denotes and
T12046 2241-2244 DT denotes the
T12047 2245-2249 NN denotes dCGN
T12048 2250-2259 JJ denotes molecular
T12049 2260-2264 NN denotes size
T12050 2264-2265 -COMMA- denotes ,
T12051 2266-2270 RB denotes thus
T12052 2271-2281 VB denotes confirming
T12053 2282-2285 DT denotes the
T12054 2286-2290 NN denotes size
T12055 2291-2298 JJ denotes related
T12056 2299-2311 NN denotes inflammation
T12057 2312-2314 FW denotes in
T12058 2315-2319 FW denotes vivo
T12059 2321-2325 DT denotes This
T12060 2326-2336 NN denotes macrophage
T12061 2337-2349 NN denotes accumulation
T12062 2350-2353 VB denotes was
T12063 2354-2357 RB denotes not
T12064 2358-2361 JJ denotes due
T12065 2362-2364 TO denotes to
T12066 2365-2369 NN denotes cell
T12067 2370-2383 NN denotes proliferation
T12068 2384-2391 IN denotes because
T12069 2392-2396 NN denotes dCGN
T12070 2397-2406 VB denotes inhibited
T12071 2407-2412 NN denotes THP-1
T12072 2413-2422 NN denotes monocytes
T12073 2423-2436 NN denotes proliferation
T12074 2437-2439 FW denotes in
T12075 2440-2445 FW denotes vitro
T12076 2447-2452 DT denotes These
T12077 2453-2460 NN denotes results
T12078 2461-2464 VB denotes are
T12079 2465-2472 JJ denotes similar
T12080 2473-2475 TO denotes to
T12081 2476-2481 DT denotes those
T12082 2482-2490 VB denotes obtained
T12083 2491-2495 IN denotes with
T12084 2496-2501 JJ denotes human
T12085 2502-2509 JJ denotes colonic
T12086 2510-2520 JJ denotes epithelial
T12087 2521-2526 NN denotes cells
T12088 2527-2528 -LRB- denotes (
T12089 2528-2534 NN denotes NCM460
T12090 2535-2539 NN denotes cell
T12091 2540-2544 NN denotes line
T12092 2544-2545 -RRB- denotes )
T12093 2546-2553 VB denotes exposed
T12094 2554-2556 TO denotes to
T12095 2557-2563 JJ denotes native
T12096 2564-2567 NN denotes CGN
T12097 2568-2571 IN denotes for
T12098 2572-2575 CD denotes 1–8
T12099 2576-2580 NN denotes days
T12100 2581-2582 -LRB- denotes [
T12101 2582-2584 CD denotes 37
T12102 2584-2585 -RRB- denotes ]
T12103 2587-2591 RB denotes Thus
T12104 2591-2592 -COMMA- denotes ,
T12105 2593-2595 PRP denotes it
T12106 2596-2601 VB denotes seems
T12107 2602-2606 IN denotes that
T12108 2607-2611 NN denotes dCGN
T12109 2612-2619 VB denotes promote
T12110 2620-2630 NN denotes macrophage
T12111 2631-2643 NN denotes infiltration
T12112 2644-2646 IN denotes by
T12113 2647-2657 VB denotes recruiting
T12114 2658-2661 JJ denotes new
T12115 2662-2667 NN denotes cells
T12116 2668-2670 TO denotes to
T12117 2671-2674 DT denotes the
T12118 2675-2683 JJ denotes inflamed
T12119 2684-2694 JJ denotes intestinal
T12120 2695-2701 NN denotes mucosa
T12121 2702-2705 CC denotes and
T12122 2706-2709 RB denotes not
T12123 2710-2712 IN denotes by
T12124 2713-2721 VB denotes inducing
T12125 2722-2726 NN denotes cell
T12126 2727-2740 NN denotes proliferation
T12127 2742-2744 IN denotes In
T12128 2745-2753 NN denotes addition
T12129 2753-2754 -COMMA- denotes ,
T12130 2755-2759 RB denotes very
T12131 2760-2763 JJ denotes few
T12132 2764-2781 JJ denotes polymorphonuclear
T12133 2782-2787 NN denotes cells
T12134 2788-2792 VB denotes were
T12135 2793-2801 VB denotes detected
T12136 2802-2804 IN denotes in
T12137 2805-2808 DT denotes the
T12138 2809-2815 NN denotes mucosa
T12139 2816-2818 IN denotes at
T12140 2819-2822 DT denotes the
T12141 2823-2827 NN denotes time
T12142 2828-2833 NN denotes point
T12143 2834-2842 VB denotes analyzed
T12144 2843-2845 IN denotes as
T12145 2846-2858 VB denotes demonstrated
T12146 2859-2861 IN denotes by
T12147 2862-2863 DT denotes a
T12148 2864-2868 RB denotes very
T12149 2869-2872 JJ denotes low
T12150 2873-2878 NN denotes level
T12151 2879-2881 IN denotes of
T12152 2882-2885 NN denotes MPO
T12153 2886-2888 IN denotes in
T12154 2889-2892 DT denotes the
T12155 2893-2903 JJ denotes intestinal
T12156 2904-2910 NN denotes tissue
T12157 2912-2917 DT denotes These
T12158 2918-2925 NN denotes results
T12159 2926-2933 VB denotes suggest
T12160 2934-2938 IN denotes that
T12161 2939-2948 NN denotes monocytes
T12162 2949-2954 MD denotes might
T12163 2955-2962 VB denotes produce
T12164 2963-2972 NN denotes cytokines
T12165 2973-2983 VB denotes associated
T12166 2984-2988 IN denotes with
T12167 2989-2999 NN denotes activation
T12168 3000-3004 IN denotes into
T12169 3005-3016 NN denotes macrophages
T12170 3017-3019 IN denotes in
T12171 3020-3028 NN denotes response
T12172 3029-3031 TO denotes to
T12173 3032-3036 NN denotes dCGN
T12174 3038-3042 RB denotes Thus
T12175 3042-3043 -COMMA- denotes ,
T12176 3044-3046 PRP denotes we
T12177 3047-3055 VB denotes analyzed
T12178 3056-3059 DT denotes the
T12179 3060-3070 NN denotes production
T12180 3071-3073 IN denotes of
T12181 3074-3077 NN denotes TNF
T12182 3078-3080 IN denotes by
T12183 3081-3085 CC denotes both
T12184 3086-3089 NN denotes PBM
T12185 3090-3093 CC denotes and
T12186 3094-3099 NN denotes THP-1
T12187 3100-3105 NN denotes cells
T12188 3106-3108 IN denotes in
T12189 3109-3117 NN denotes response
T12190 3118-3120 TO denotes to
T12191 3121-3125 NN denotes dCGN
T12192 3127-3135 VB denotes Degraded
T12193 3136-3139 NN denotes CGN
T12194 3140-3147 VB denotes induced
T12195 3148-3149 DT denotes a
T12196 3150-3156 JJ denotes robust
T12197 3157-3167 NN denotes production
T12198 3168-3170 IN denotes of
T12199 3171-3174 NN denotes TNF
T12200 3175-3177 IN denotes by
T12201 3178-3187 NN denotes monocytes
T12202 3189-3192 DT denotes The
T12203 3193-3195 CD denotes 40
T12204 3196-3199 NN denotes kDa
T12205 3200-3204 NN denotes form
T12206 3205-3207 IN denotes of
T12207 3208-3212 NN denotes dCGN
T12208 3213-3216 VB denotes was
T12209 3217-3221 RB denotes more
T12210 3222-3228 JJ denotes potent
T12211 3229-3232 IN denotes for
T12212 3233-3241 NN denotes monocyte
T12213 3242-3253 NN denotes stimulation
T12214 3254-3258 IN denotes than
T12215 3259-3262 DT denotes the
T12216 3263-3265 CD denotes 10
T12217 3266-3269 NN denotes kDa
T12218 3270-3272 CC denotes or
T12219 3273-3276 DT denotes the
T12220 3277-3283 JJ denotes native
T12221 3284-3288 NN denotes ones
T12222 3290-3302 RB denotes Surprisingly
T12223 3302-3303 -COMMA- denotes ,
T12224 3304-3312 NN denotes monocyte
T12225 3313-3323 NN denotes activation
T12226 3324-3326 IN denotes by
T12227 3327-3331 NN denotes dCGN
T12228 3332-3334 TO denotes to
T12229 3335-3342 VB denotes produce
T12230 3343-3346 NN denotes TNF
T12231 3347-3350 VB denotes was
T12232 3351-3355 RB denotes much
T12233 3356-3364 JJ denotes stronger
T12234 3365-3369 IN denotes than
T12235 3370-3373 DT denotes the
T12236 3374-3384 NN denotes activation
T12237 3385-3392 VB denotes induced
T12238 3393-3395 IN denotes by
T12239 3396-3399 NN denotes LPS
T12240 3399-3400 -COMMA- denotes ,
T12241 3401-3403 DT denotes an
T12242 3404-3416 JJ denotes inflammatory
T12243 3417-3423 NN denotes factor
T12244 3424-3434 VB denotes considered
T12245 3435-3437 TO denotes to
T12246 3438-3440 VB denotes be
T12247 3441-3446 IN denotes among
T12248 3447-3450 DT denotes the
T12249 3451-3455 RB denotes most
T12250 3456-3462 JJ denotes potent
T12251 3463-3470 NN denotes stimuli
T12252 3471-3474 IN denotes for
T12253 3475-3484 NN denotes leukocyte
T12254 3485-3495 NN denotes activation
T12255 3497-3502 DT denotes These
T12256 3503-3510 NN denotes results
T12257 3511-3520 VB denotes underline
T12258 3521-3524 DT denotes the
T12259 3525-3529 NN denotes fact
T12260 3530-3534 IN denotes that
T12261 3535-3544 RB denotes partially
T12262 3545-3553 VB denotes degraded
T12263 3554-3559 NN denotes forms
T12264 3560-3562 IN denotes of
T12265 3563-3566 NN denotes CGN
T12266 3567-3571 VB denotes have
T12267 3572-3581 JJ denotes important
T12268 3582-3590 JJ denotes cellular
T12269 3591-3598 NN denotes effects
T12270 3600-3603 DT denotes The
T12271 3604-3610 NN denotes amount
T12272 3611-3613 IN denotes of
T12273 3614-3617 NN denotes TNF
T12274 3618-3626 VB denotes secreted
T12275 3627-3629 IN denotes by
T12276 3630-3633 NN denotes PBM
T12277 3634-3641 VB denotes induced
T12278 3642-3646 IN denotes with
T12279 3647-3650 NN denotes LPS
T12280 3651-3654 VB denotes was
T12281 3655-3659 RB denotes much
T12282 3660-3666 JJ denotes larger
T12283 3667-3671 IN denotes than
T12284 3672-3675 DT denotes the
T12285 3676-3679 CD denotes one
T12286 3680-3688 VB denotes secreted
T12287 3689-3691 IN denotes by
T12288 3692-3697 NN denotes THP-1
T12289 3698-3707 NN denotes monocytes
T12290 3709-3714 IN denotes Since
T12291 3715-3723 NN denotes monocyte
T12292 3724-3734 NN denotes activation
T12293 3735-3737 IN denotes by
T12294 3738-3741 NN denotes LPS
T12295 3742-3744 VB denotes is
T12296 3745-3755 VB denotes associated
T12297 3756-3760 IN denotes with
T12298 3761-3764 DT denotes the
T12299 3765-3773 NN denotes presence
T12300 3774-3776 IN denotes of
T12301 3777-3780 DT denotes the
T12302 3781-3785 NN denotes CD14
T12303 3786-3789 CC denotes and
T12304 3790-3794 NN denotes TLR4
T12305 3795-3804 NN denotes receptors
T12306 3805-3806 -LRB- denotes [
T12307 3806-3808 CD denotes 38
T12308 3808-3809 -RRB- denotes ]
T12309 3809-3810 CD denotes –
T12310 3810-3811 -LRB- denotes [
T12311 3811-3813 CD denotes 40
T12312 3813-3814 -RRB- denotes ]
T12313 3814-3815 -COMMA- denotes ,
T12314 3816-3819 DT denotes the
T12315 3820-3829 JJ denotes different
T12316 3830-3838 NN denotes response
T12317 3839-3847 VB denotes observed
T12318 3848-3853 MD denotes could
T12319 3854-3856 VB denotes be
T12320 3857-3860 JJ denotes due
T12321 3861-3863 TO denotes to
T12322 3864-3867 DT denotes the
T12323 3868-3877 JJ denotes different
T12324 3878-3888 NN denotes expression
T12325 3889-3891 IN denotes of
T12326 3892-3897 DT denotes these
T12327 3898-3907 NN denotes receptors
T12328 3908-3910 IN denotes in
T12329 3911-3914 NN denotes PBM
T12330 3915-3918 CC denotes and
T12331 3919-3924 NN denotes THP-1
T12332 3925-3930 NN denotes cells
T12333 3932-3936 NN denotes CD14
T12334 3937-3939 VB denotes is
T12335 3940-3943 RB denotes not
T12336 3944-3953 VB denotes expressed
T12337 3954-3956 IN denotes by
T12338 3957-3962 NN denotes THP-1
T12339 3963-3972 NN denotes monocytes
T12340 3972-3973 -COMMA- denotes ,
T12341 3974-3977 CC denotes but
T12342 3978-3980 PRP denotes it
T12343 3981-3983 VB denotes is
T12344 3984-3993 VB denotes expressed
T12345 3994-3996 IN denotes by
T12346 3997-4000 NN denotes PBM
T12347 4002-4006 DT denotes This
T12348 4007-4011 NN denotes fact
T12349 4012-4017 MD denotes could
T12350 4018-4025 VB denotes explain
T12351 4026-4029 WRB denotes why
T12352 4030-4035 NN denotes THP-1
T12353 4036-4041 NN denotes cells
T12354 4042-4050 VB denotes produced
T12355 4051-4052 DT denotes a
T12356 4053-4057 RB denotes much
T12357 4058-4065 JJ denotes smaller
T12358 4066-4074 NN denotes response
T12359 4075-4077 TO denotes to
T12360 4078-4081 NN denotes LPS
T12361 4082-4086 IN denotes than
T12362 4087-4090 NN denotes PBM
T12363 4091-4094 CC denotes and
T12364 4095-4099 RB denotes also
T12365 4100-4103 DT denotes the
T12366 4104-4114 NN denotes difference
T12367 4115-4117 IN denotes of
T12368 4118-4126 NN denotes kinetics
T12369 4127-4129 IN denotes in
T12370 4130-4133 DT denotes the
T12371 4134-4137 NN denotes LPS
T12372 4138-4145 VB denotes induced
T12373 4146-4149 NN denotes TNF
T12374 4150-4159 NN denotes secretion
T12375 4161-4164 DT denotes The
T12376 4165-4169 NN denotes peak
T12377 4170-4172 IN denotes of
T12378 4173-4176 NN denotes TNF
T12379 4177-4185 NN denotes response
T12380 4186-4189 VB denotes was
T12381 4190-4198 VB denotes observed
T12382 4199-4204 IN denotes after
T12383 4205-4206 CD denotes 8
T12384 4207-4208 NN denotes h
T12385 4209-4220 NN denotes stimulation
T12386 4221-4229 VB denotes followed
T12387 4230-4232 IN denotes by
T12388 4233-4234 DT denotes a
T12389 4235-4240 JJ denotes rapid
T12390 4241-4249 NN denotes decrease
T12391 4250-4252 TO denotes to
T12392 4253-4261 NN denotes baseline
T12393 4262-4264 IN denotes at
T12394 4265-4267 CD denotes 10
T12395 4268-4269 NN denotes h
T12396 4269-4270 -COMMA- denotes ,
T12397 4271-4278 IN denotes whereas
T12398 4279-4281 IN denotes on
T12399 4282-4287 NN denotes THP-1
T12400 4288-4293 NN denotes cells
T12401 4294-4297 DT denotes the
T12402 4298-4302 NN denotes peak
T12403 4303-4306 VB denotes was
T12404 4307-4310 RB denotes not
T12405 4311-4318 VB denotes reached
T12406 4319-4324 IN denotes until
T12407 4325-4330 IN denotes after
T12408 4331-4333 CD denotes 56
T12409 4334-4335 NN denotes h
T12410 4337-4345 RB denotes Moreover
T12411 4345-4346 -COMMA- denotes ,
T12412 4347-4350 DT denotes the
T12413 4351-4357 NN denotes amount
T12414 4358-4360 IN denotes of
T12415 4361-4364 NN denotes TNF
T12416 4365-4373 VB denotes secreted
T12417 4374-4376 IN denotes by
T12418 4377-4386 NN denotes monocytes
T12419 4387-4394 VB denotes induced
T12420 4395-4399 IN denotes with
T12421 4400-4404 NN denotes dCGN
T12422 4405-4408 VB denotes was
T12423 4409-4413 RB denotes much
T12424 4414-4420 JJ denotes larger
T12425 4421-4425 IN denotes than
T12426 4426-4429 DT denotes the
T12427 4430-4433 NN denotes one
T12428 4434-4441 VB denotes induced
T12429 4442-4444 IN denotes by
T12430 4445-4448 NN denotes LPS
T12431 4450-4452 IN denotes On
T12432 4453-4456 DT denotes the
T12433 4457-4462 JJ denotes other
T12434 4463-4467 NN denotes hand
T12435 4467-4468 -COMMA- denotes ,
T12436 4469-4472 NN denotes LPS
T12437 4473-4476 CC denotes and
T12438 4477-4481 NN denotes dCGN
T12439 4482-4491 VB denotes displayed
T12440 4492-4493 DT denotes a
T12441 4494-4498 RB denotes very
T12442 4499-4508 JJ denotes different
T12443 4509-4512 NN denotes TNF
T12444 4513-4522 NN denotes secretion
T12445 4523-4528 NN denotes curve
T12446 4529-4531 IN denotes in
T12447 4532-4537 NN denotes THP-1
T12448 4538-4543 NN denotes cells
T12449 4545-4550 DT denotes These
T12450 4551-4562 NN denotes differences
T12451 4563-4570 VB denotes suggest
T12452 4571-4575 IN denotes that
T12453 4576-4580 NN denotes dCGN
T12454 4581-4584 CC denotes and
T12455 4585-4588 NN denotes LPS
T12456 4589-4594 MD denotes could
T12457 4595-4598 VB denotes use
T12458 4599-4608 JJ denotes different
T12459 4609-4619 NN denotes activation
T12460 4620-4630 NN denotes mechanisms
T12461 4632-4634 PRP denotes It
T12462 4635-4637 VB denotes is
T12463 4638-4648 JJ denotes noteworthy
T12464 4649-4653 IN denotes that
T12465 4654-4666 VB denotes neutralizing
T12466 4667-4675 NN denotes antibody
T12467 4676-4678 TO denotes to
T12468 4679-4683 NN denotes CD14
T12469 4684-4688 RB denotes only
T12470 4689-4698 RB denotes partially
T12471 4699-4700 -LRB- denotes (
T12472 4700-4701 SYM denotes <
T12473 4701-4703 CD denotes 40
T12474 4703-4704 NN denotes %
T12475 4704-4705 -RRB- denotes )
T12476 4706-4715 VB denotes inhibited
T12477 4716-4728 JJ denotes dCGN-induced
T12478 4729-4732 NN denotes TNF
T12479 4733-4742 NN denotes secretion
T12480 4743-4744 -LRB- denotes (
T12481 4744-4747 RB denotes not
T12482 4748-4753 VB denotes shown
T12483 4753-4754 -RRB- denotes )
T12484 4756-4760 NN denotes TLR4
T12485 4761-4764 VB denotes has
T12486 4765-4769 VB denotes been
T12487 4770-4778 RB denotes recently
T12488 4779-4789 VB denotes identified
T12489 4790-4792 IN denotes as
T12490 4793-4794 DT denotes a
T12491 4795-4802 NN denotes surface
T12492 4803-4811 NN denotes membrane
T12493 4812-4820 NN denotes receptor
T12494 4821-4824 IN denotes for
T12495 4825-4828 NN denotes CGN
T12496 4829-4831 IN denotes in
T12497 4832-4837 JJ denotes human
T12498 4838-4845 JJ denotes colonic
T12499 4846-4856 JJ denotes epithelial
T12500 4857-4862 NN denotes cells
T12501 4863-4864 -LRB- denotes [
T12502 4864-4866 CD denotes 41
T12503 4866-4867 -RRB- denotes ]
T12504 4869-4873 RB denotes Thus
T12505 4873-4874 -COMMA- denotes ,
T12506 4875-4877 PRP denotes it
T12507 4878-4880 VB denotes is
T12508 4881-4889 JJ denotes possible
T12509 4890-4894 IN denotes that
T12510 4895-4899 NN denotes TLR4
T12511 4900-4902 VB denotes is
T12512 4903-4912 VB denotes activated
T12513 4913-4915 IN denotes by
T12514 4916-4920 NN denotes dCGN
T12515 4921-4923 TO denotes to
T12516 4924-4930 VB denotes induce
T12517 4931-4939 NN denotes cytokine
T12518 4940-4949 NN denotes secretion
T12519 4950-4952 IN denotes by
T12520 4953-4962 NN denotes monocytes
T12521 4964-4966 PRP denotes We
T12522 4967-4970 MD denotes can
T12523 4971-4975 RB denotes only
T12524 4976-4985 VB denotes speculate
T12525 4986-4990 IN denotes that
T12526 4991-4995 NN denotes TLR4
T12527 4996-4999 MD denotes may
T12528 5000-5004 VB denotes have
T12529 5005-5006 DT denotes a
T12530 5007-5013 JJ denotes higher
T12531 5014-5030 JJ denotes affinity-binding
T12532 5031-5035 NN denotes site
T12533 5036-5039 IN denotes for
T12534 5040-5044 NN denotes dCGN
T12535 5045-5049 IN denotes than
T12536 5050-5053 IN denotes for
T12537 5054-5057 NN denotes LPS
T12538 5057-5058 -COMMA- denotes ,
T12539 5059-5066 RB denotes however
T12540 5066-5067 -COMMA- denotes ,
T12541 5068-5072 DT denotes this
T12542 5073-5083 NN denotes hypothesis
T12543 5084-5091 VB denotes remains
T12544 5092-5094 TO denotes to
T12545 5095-5097 VB denotes be
T12546 5098-5104 VB denotes tested
T12547 5106-5113 DT denotes Another
T12548 5114-5123 NN denotes indicator
T12549 5124-5128 IN denotes that
T12550 5129-5133 NN denotes dCGN
T12551 5134-5143 VB denotes stimulate
T12552 5144-5153 NN denotes monocytes
T12553 5154-5161 VB denotes leading
T12554 5162-5164 TO denotes to
T12555 5165-5166 DT denotes a
T12556 5167-5171 RB denotes more
T12557 5172-5178 JJ denotes active
T12558 5179-5188 NN denotes phenotype
T12559 5189-5191 VB denotes is
T12560 5192-5195 DT denotes the
T12561 5196-5200 NN denotes fact
T12562 5201-5205 IN denotes that
T12563 5206-5213 NN denotes surface
T12564 5214-5224 NN denotes expression
T12565 5225-5227 IN denotes of
T12566 5228-5231 DT denotes the
T12567 5232-5240 NN denotes adhesion
T12568 5241-5249 NN denotes molecule
T12569 5250-5256 NN denotes ICAM-1
T12570 5257-5260 VB denotes was
T12571 5261-5269 VB denotes enhanced
T12572 5270-5272 IN denotes in
T12573 5273-5277 CC denotes both
T12574 5278-5281 NN denotes PBM
T12575 5282-5285 CC denotes and
T12576 5286-5291 NN denotes THP-1
T12577 5292-5297 NN denotes cells
T12578 5299-5302 DT denotes The
T12579 5303-5307 IN denotes over
T12580 5308-5318 NN denotes expression
T12581 5319-5321 IN denotes of
T12582 5322-5328 NN denotes ICAM-1
T12583 5329-5335 VB denotes caused
T12584 5336-5339 DT denotes the
T12585 5340-5349 VB denotes activated
T12586 5350-5359 NN denotes monocytes
T12587 5360-5362 TO denotes to
T12588 5363-5367 VB denotes form
T12589 5368-5372 NN denotes cell
T12590 5373-5383 NN denotes aggregates
T12591 5384-5388 WDT denotes that
T12592 5389-5393 VB denotes were
T12593 5394-5398 RB denotes more
T12594 5399-5407 JJ denotes abundant
T12595 5408-5413 IN denotes among
T12596 5414-5419 NN denotes cells
T12597 5420-5427 VB denotes treated
T12598 5428-5432 IN denotes with
T12599 5433-5436 DT denotes the
T12600 5437-5439 CD denotes 40
T12601 5440-5443 NN denotes kDa
T12602 5444-5448 NN denotes dCGN
T12603 5450-5454 DT denotes This
T12604 5455-5465 VB denotes correlates
T12605 5466-5470 IN denotes with
T12606 5471-5474 DT denotes the
T12607 5475-5481 JJ denotes higher
T12608 5482-5492 NN denotes expression
T12609 5493-5495 IN denotes of
T12610 5496-5502 NN denotes ICAM-1
T12611 5503-5510 VB denotes induced
T12612 5511-5513 IN denotes by
T12613 5514-5517 DT denotes the
T12614 5518-5520 CD denotes 40
T12615 5521-5524 NN denotes kDa
T12616 5525-5529 NN denotes dCGN
T12617 5529-5530 -COMMA- denotes ,
T12618 5531-5541 VB denotes suggesting
T12619 5542-5546 IN denotes that
T12620 5547-5550 DT denotes the
T12621 5551-5560 RB denotes partially
T12622 5561-5569 VB denotes degraded
T12623 5570-5573 NN denotes CGN
T12624 5574-5576 VB denotes is
T12625 5577-5581 RB denotes more
T12626 5582-5594 RB denotes biologically
T12627 5595-5601 JJ denotes active
T12628 5603-5605 IN denotes In
T12629 5606-5614 NN denotes addition
T12630 5614-5615 -COMMA- denotes ,
T12631 5616-5619 DT denotes the
T12632 5620-5624 NN denotes cell
T12633 5625-5635 NN denotes aggregates
T12634 5636-5639 VB denotes are
T12635 5640-5651 JJ denotes reminiscent
T12636 5652-5654 IN denotes of
T12637 5655-5663 NN denotes monocyte
T12638 5664-5674 NN denotes aggregates
T12639 5674-5675 -COMMA- denotes ,
T12640 5676-5681 WDT denotes which
T12641 5682-5686 VB denotes form
T12642 5687-5701 JJ denotes multinucleated
T12643 5702-5707 JJ denotes giant
T12644 5708-5713 NN denotes cells
T12645 5714-5715 -LRB- denotes (
T12646 5715-5718 NN denotes MGC
T12647 5718-5719 -RRB- denotes )
T12648 5720-5722 IN denotes in
T12649 5723-5731 NN denotes patients
T12650 5732-5736 IN denotes with
T12651 5737-5742 NN denotes Crohn
T12652 5742-5744 POS denotes 's
T12653 5745-5752 NN denotes disease
T12654 5753-5754 -LRB- denotes [
T12655 5754-5756 CD denotes 42
T12656 5756-5757 -RRB- denotes ]
T12657 5759-5764 DT denotes These
T12658 5765-5770 JJ denotes giant
T12659 5771-5776 NN denotes cells
T12660 5777-5781 VB denotes were
T12661 5782-5785 RB denotes not
T12662 5786-5794 VB denotes observed
T12663 5795-5797 IN denotes in
T12664 5798-5805 JJ denotes healthy
T12665 5806-5817 NN denotes individuals
T12666 5818-5820 CC denotes or
T12667 5821-5823 IN denotes in
T12668 5824-5832 NN denotes patients
T12669 5833-5837 IN denotes with
T12670 5838-5848 JJ denotes ulcerative
T12671 5849-5856 NN denotes colitis
T12672 5857-5858 -LRB- denotes [
T12673 5858-5860 CD denotes 42
T12674 5860-5861 -RRB- denotes ]
T12675 5863-5871 RB denotes Moreover
T12676 5871-5872 -COMMA- denotes ,
T12677 5873-5882 VB denotes increased
T12678 5883-5893 NN denotes expression
T12679 5894-5900 NN denotes levels
T12680 5901-5903 IN denotes of
T12681 5904-5910 NN denotes ICAM-1
T12682 5911-5914 CC denotes and
T12683 5915-5920 NN denotes LFA-3
T12684 5921-5922 -LRB- denotes (
T12685 5922-5926 NN denotes CD58
T12686 5926-5927 -RRB- denotes )
T12687 5928-5932 VB denotes were
T12688 5933-5937 RB denotes also
T12689 5938-5946 VB denotes detected
T12690 5947-5949 IN denotes in
T12691 5950-5959 NN denotes monocytes
T12692 5960-5964 IN denotes from
T12693 5965-5973 NN denotes patients
T12694 5974-5978 IN denotes with
T12695 5979-5984 NN denotes Crohn
T12696 5984-5986 POS denotes 's
T12697 5987-5994 NN denotes disease
T12698 5995-5996 -LRB- denotes [
T12699 5996-5998 CD denotes 43
T12700 5998-5999 -RRB- denotes ]
T12701 5999-6000 -COMMA- denotes ,
T12702 6001-6002 -LRB- denotes [
T12703 6002-6004 CD denotes 44
T12704 6004-6005 -RRB- denotes ]
T12705 6007-6011 RB denotes Thus
T12706 6011-6012 -COMMA- denotes ,
T12707 6013-6021 VB denotes degraded
T12708 6022-6025 NN denotes CGN
T12709 6026-6033 RB denotes clearly
T12710 6034-6037 MD denotes can
T12711 6038-6046 VB denotes activate
T12712 6047-6056 NN denotes monocytes
T12713 6057-6059 TO denotes to
T12714 6060-6067 VB denotes express
T12715 6068-6070 DT denotes an
T12716 6071-6080 VB denotes increased
T12717 6081-6087 NN denotes number
T12718 6088-6090 IN denotes of
T12719 6091-6097 NN denotes ICAM-1
T12720 6098-6106 NN denotes adhesion
T12721 6107-6116 NN denotes molecules
T12722 6116-6117 -COMMA- denotes ,
T12723 6118-6127 RB denotes therefore
T12724 6128-6133 VB denotes being
T12725 6134-6141 JJ denotes capable
T12726 6142-6144 IN denotes of
T12727 6145-6153 VB denotes creating
T12728 6154-6157 DT denotes the
T12729 6158-6168 NN denotes conditions
T12730 6169-6183 JJ denotes characteristic
T12731 6184-6186 IN denotes of
T12732 6187-6192 NN denotes Crohn
T12733 6192-6194 POS denotes 's
T12734 6195-6202 NN denotes disease
T12735 6203-6217 NN denotes symptomatology
T12736 6217-6218 -COMMA- denotes ,
T12737 6219-6223 FW denotes i.e.
T12738 6224-6227 NN denotes PBM
T12739 6228-6240 NN denotes accumulation
T12740 6241-6244 CC denotes and
T12741 6245-6248 NN denotes MGC
T12742 6249-6258 NN denotes formation
T12743 6259-6260 -LRB- denotes [
T12744 6260-6262 CD denotes 45
T12745 6262-6263 -RRB- denotes ]
T12746 6263-6264 -COMMA- denotes ,
T12747 6265-6266 -LRB- denotes [
T12748 6266-6268 CD denotes 46
T12749 6268-6269 -RRB- denotes ]
T12750 6271-6274 DT denotes The
T12751 6275-6280 NN denotes NF-κB
T12752 6281-6288 NN denotes pathway
T12753 6289-6298 VB denotes regulates
T12754 6299-6304 NN denotes genes
T12755 6305-6316 JJ denotes responsible
T12756 6317-6320 IN denotes for
T12757 6321-6327 NN denotes ICAM-1
T12758 6328-6331 CC denotes and
T12759 6332-6337 NN denotes TNF-α
T12760 6338-6348 NN denotes expression
T12761 6350-6355 NN denotes NF-κB
T12762 6356-6366 NN denotes activation
T12763 6367-6369 VB denotes is
T12764 6370-6380 VB denotes associated
T12765 6381-6385 IN denotes with
T12766 6386-6389 DT denotes the
T12767 6390-6401 NN denotes degradation
T12768 6402-6404 IN denotes of
T12769 6405-6408 DT denotes the
T12770 6409-6418 NN denotes inhibitor
T12771 6419-6426 NN denotes protein
T12772 6427-6430 NN denotes IκB
T12773 6431-6432 -LRB- denotes [
T12774 6432-6434 CD denotes 47
T12775 6434-6435 -RRB- denotes ]
T12776 6437-6443 RB denotes Indeed
T12777 6443-6444 -COMMA- denotes ,
T12778 6445-6449 NN denotes dCGN
T12779 6450-6457 VB denotes induced
T12780 6458-6463 NN denotes NF-κB
T12781 6464-6474 NN denotes activation
T12782 6475-6477 IN denotes as
T12783 6478-6483 VB denotes shown
T12784 6484-6486 IN denotes by
T12785 6487-6498 NN denotes degradation
T12786 6499-6501 IN denotes of
T12787 6502-6506 NN denotes IκBα
T12788 6506-6507 -COMMA- denotes ,
T12789 6508-6521 NN denotes translocation
T12790 6522-6524 IN denotes of
T12791 6525-6528 NN denotes p65
T12792 6529-6532 CC denotes and
T12793 6533-6536 NN denotes p50
T12794 6537-6546 NN denotes sub-units
T12795 6547-6549 TO denotes to
T12796 6550-6553 DT denotes the
T12797 6554-6561 NN denotes nucleus
T12798 6562-6565 CC denotes and
T12799 6566-6568 IN denotes by
T12800 6569-6579 NN denotes activation
T12801 6580-6582 IN denotes of
T12802 6583-6585 DT denotes an
T12803 6586-6602 JJ denotes NF-κB-responsive
T12804 6603-6613 NN denotes luciferase
T12805 6614-6622 NN denotes reporter
T12806 6623-6630 NN denotes plasmid
T12807 6632-6637 RB denotes Again
T12808 6637-6638 -COMMA- denotes ,
T12809 6639-6640 DT denotes a
T12810 6641-6649 JJ denotes stronger
T12811 6650-6660 NN denotes activation
T12812 6661-6663 IN denotes of
T12813 6664-6669 NN denotes NF-κB
T12814 6670-6673 VB denotes was
T12815 6674-6681 VB denotes induced
T12816 6682-6684 IN denotes by
T12817 6685-6688 DT denotes the
T12818 6689-6691 CD denotes 40
T12819 6692-6695 NN denotes kDa
T12820 6696-6700 NN denotes dCGN
T12821 6701-6709 VB denotes compared
T12822 6710-6712 TO denotes to
T12823 6713-6715 CD denotes 10
T12824 6716-6719 NN denotes kDa
T12825 6720-6724 NN denotes dCGN
T12826 6724-6725 -COMMA- denotes ,
T12827 6726-6736 VB denotes suggesting
T12828 6737-6741 IN denotes that
T12829 6742-6745 DT denotes the
T12830 6746-6755 RB denotes partially
T12831 6756-6764 VB denotes degraded
T12832 6765-6768 NN denotes CGN
T12833 6769-6771 VB denotes is
T12834 6772-6776 RB denotes more
T12835 6777-6789 RB denotes biologically
T12836 6790-6796 JJ denotes active
T12837 6798-6801 PRP-DOLLAR- denotes Our
T12838 6802-6806 NN denotes data
T12839 6807-6810 VB denotes are
T12840 6811-6813 IN denotes in
T12841 6814-6823 NN denotes agreement
T12842 6824-6828 IN denotes with
T12843 6829-6830 DT denotes a
T12844 6831-6839 JJ denotes previous
T12845 6840-6845 NN denotes study
T12846 6846-6853 VB denotes showing
T12847 6854-6858 IN denotes that
T12848 6859-6865 JJ denotes native
T12849 6866-6869 NN denotes CGN
T12850 6870-6874 RB denotes also
T12851 6875-6882 VB denotes induced
T12852 6883-6893 NN denotes activation
T12853 6894-6896 IN denotes of
T12854 6897-6902 NN denotes NF-κB
T12855 6903-6905 IN denotes in
T12856 6906-6911 JJ denotes human
T12857 6912-6919 JJ denotes colonic
T12858 6920-6930 JJ denotes epithelial
T12859 6931-6936 NN denotes cells
T12860 6937-6938 -LRB- denotes [
T12861 6938-6940 CD denotes 48
T12862 6940-6941 -RRB- denotes ]
T12863 6943-6948 NN denotes NF-κB
T12864 6949-6956 NN denotes pathway
T12865 6957-6959 VB denotes is
T12866 6960-6965 RB denotes often
T12867 6966-6976 VB denotes associated
T12868 6977-6979 TO denotes to
T12869 6980-6987 VB denotes promote
T12870 6988-6992 NN denotes cell
T12871 6993-7001 NN denotes survival
T12872 7002-7005 CC denotes and
T12873 7006-7012 NN denotes cancer
T12874 7013-7017 NN denotes cell
T12875 7018-7024 NN denotes growth
T12876 7024-7025 -COMMA- denotes ,
T12877 7026-7033 RB denotes however
T12878 7034-7036 PRP denotes it
T12879 7037-7040 VB denotes has
T12880 7041-7045 VB denotes been
T12881 7046-7055 RB denotes sometimes
T12882 7056-7064 VB denotes reported
T12883 7065-7067 TO denotes to
T12884 7068-7074 VB denotes behave
T12885 7075-7077 IN denotes as
T12886 7078-7079 DT denotes a
T12887 7080-7085 NN denotes tumor
T12888 7086-7096 NN denotes suppressor
T12889 7096-7097 -COMMA- denotes ,
T12890 7098-7107 VB denotes arresting
T12891 7108-7112 NN denotes cell
T12892 7113-7126 NN denotes proliferation
T12893 7127-7128 -LRB- denotes [
T12894 7128-7130 CD denotes 49
T12895 7130-7131 -RRB- denotes ]
T12896 7133-7137 JJ denotes Such
T12897 7138-7150 NN denotes relationship
T12898 7151-7158 IN denotes between
T12899 7159-7164 NN denotes NF-kB
T12900 7165-7175 NN denotes activation
T12901 7176-7179 CC denotes and
T12902 7180-7184 NN denotes cell
T12903 7185-7190 NN denotes cycle
T12904 7191-7201 NN denotes regulation
T12905 7202-7205 VB denotes has
T12906 7206-7210 VB denotes been
T12907 7211-7219 VB denotes reported
T12908 7220-7222 IN denotes in
T12909 7223-7229 JJ denotes normal
T12910 7230-7235 JJ denotes human
T12911 7236-7245 JJ denotes epidermal
T12912 7246-7251 NN denotes cells
T12913 7252-7253 -LRB- denotes [
T12914 7253-7255 CD denotes 50
T12915 7255-7256 -RRB- denotes ]
T12916 7258-7264 RB denotes Indeed
T12917 7264-7265 -COMMA- denotes ,
T12918 7266-7268 PRP denotes it
T12919 7269-7272 VB denotes has
T12920 7273-7277 VB denotes been
T12921 7278-7283 VB denotes shown
T12922 7284-7288 IN denotes that
T12923 7289-7294 NN denotes NF-κB
T12924 7295-7305 NN denotes activation
T12925 7306-7316 VB denotes suppressed
T12926 7317-7321 NN denotes cdk4
T12927 7322-7332 NN denotes expression
T12928 7332-7333 -COMMA- denotes ,
T12929 7334-7339 WDT denotes which
T12930 7340-7342 VB denotes is
T12931 7343-7352 JJ denotes necessary
T12932 7353-7356 IN denotes for
T12933 7357-7360 DT denotes the
T12934 7361-7371 NN denotes transition
T12935 7372-7374 TO denotes to
T12936 7375-7376 NN denotes S
T12937 7377-7382 NN denotes phase
T12938 7384-7391 RB denotes Finally
T12939 7391-7392 -COMMA- denotes ,
T12940 7393-7398 NN denotes NF-κB
T12941 7399-7409 NN denotes activation
T12942 7410-7413 VB denotes was
T12943 7414-7422 VB denotes reported
T12944 7423-7425 TO denotes to
T12945 7426-7432 VB denotes induce
T12946 7433-7439 NN denotes growth
T12947 7440-7446 NN denotes arrest
T12948 7447-7449 IN denotes in
T12949 7450-7456 JJ denotes normal
T12950 7457-7462 JJ denotes human
T12951 7463-7476 NN denotes keratinocytes
T12952 7477-7479 IN denotes by
T12953 7480-7481 DT denotes a
T12954 7482-7491 NN denotes mechanims
T12955 7492-7501 VB denotes involving
T12956 7502-7505 DT denotes the
T12957 7506-7509 NN denotes cdk
T12958 7510-7519 NN denotes inhibitor
T12959 7520-7523 NN denotes p21
T12960 7524-7525 -LRB- denotes [
T12961 7525-7527 CD denotes 51
T12962 7527-7528 -RRB- denotes ]
T12963 7530-7533 DT denotes The
T12964 7534-7541 NN denotes effects
T12965 7542-7544 IN denotes of
T12966 7545-7549 NN denotes dCGN
T12967 7550-7552 IN denotes on
T12968 7553-7556 NN denotes p21
T12969 7557-7560 CC denotes and
T12970 7561-7565 NN denotes cdk4
T12971 7566-7576 NN denotes expression
T12972 7577-7583 VB denotes remain
T12973 7584-7586 TO denotes to
T12974 7587-7589 VB denotes be
T12975 7590-7597 VB denotes studied
T12976 7599-7601 IN denotes In
T12977 7602-7607 DT denotes these
T12978 7608-7615 NN denotes studies
T12979 7615-7616 -COMMA- denotes ,
T12980 7617-7619 PRP denotes we
T12981 7620-7624 VB denotes have
T12982 7625-7637 VB denotes demonstrated
T12983 7638-7639 DT denotes a
T12984 7640-7646 JJ denotes direct
T12985 7647-7653 NN denotes action
T12986 7654-7656 IN denotes of
T12987 7657-7661 NN denotes dCGN
T12988 7662-7664 IN denotes on
T12989 7665-7674 NN denotes monocytes
T12990 7676-7685 NN denotes Monocytes
T12991 7686-7693 VB denotes exposed
T12992 7694-7696 TO denotes to
T12993 7697-7701 NN denotes dCGN
T12994 7702-7710 VB denotes acquired
T12995 7711-7713 DT denotes an
T12996 7714-7726 JJ denotes inflammatory
T12997 7727-7736 NN denotes phenotype
T12998 7737-7741 WDT denotes that
T12999 7742-7750 VB denotes included
T13000 7751-7757 JJ denotes higher
T13001 7758-7768 NN denotes expression
T13002 7769-7771 IN denotes of
T13003 7772-7775 DT denotes the
T13004 7776-7784 NN denotes adhesion
T13005 7785-7793 NN denotes molecule
T13006 7794-7800 NN denotes ICAM-1
T13007 7801-7804 CC denotes and
T13008 7805-7810 NN denotes TNF-α
T13009 7811-7821 NN denotes production
T13010 7821-7822 -COMMA- denotes ,
T13011 7823-7826 IN denotes via
T13012 7827-7830 DT denotes the
T13013 7831-7836 NN denotes NF-κB
T13014 7837-7844 NN denotes pathway
T13015 7846-7850 DT denotes This
T13016 7851-7857 JJ denotes higher
T13017 7858-7868 NN denotes expression
T13018 7869-7871 IN denotes of
T13019 7872-7878 NN denotes ICAM-1
T13020 7879-7887 VB denotes resulted
T13021 7888-7890 IN denotes in
T13022 7891-7900 NN denotes formation
T13023 7901-7903 IN denotes of
T13024 7904-7908 NN denotes cell
T13025 7909-7919 NN denotes aggregates
T13026 7920-7927 JJ denotes similar
T13027 7928-7930 TO denotes to
T13028 7931-7936 DT denotes those
T13029 7937-7945 VB denotes observed
T13030 7946-7948 IN denotes in
T13031 7949-7957 NN denotes patients
T13032 7958-7962 IN denotes with
T13033 7963-7968 NN denotes Crohn
T13034 7968-7970 POS denotes 's
T13035 7971-7978 NN denotes disease
T13036 7980-7982 PRP denotes We
T13037 7983-7990 VB denotes presume
T13038 7991-7995 IN denotes that
T13039 7996-7999 DT denotes the
T13040 8000-8012 JJ denotes differential
T13041 8013-8020 NN denotes effects
T13042 8021-8023 IN denotes of
T13043 8024-8026 CD denotes 10
T13044 8027-8030 CC denotes and
T13045 8031-8033 CD denotes 40
T13046 8034-8037 NN denotes kDa
T13047 8038-8042 NN denotes dCGN
T13048 8043-8045 TO denotes to
T13049 8046-8052 VB denotes induce
T13050 8053-8058 DT denotes these
T13051 8059-8066 NN denotes effects
T13052 8067-8069 IN denotes on
T13053 8070-8079 NN denotes monocytes
T13054 8080-8083 VB denotes are
T13055 8084-8091 RB denotes tightly
T13056 8092-8098 VB denotes linked
T13057 8099-8101 TO denotes to
T13058 8102-8107 PRP-DOLLAR- denotes their
T13059 8108-8116 NN denotes capacity
T13060 8117-8119 TO denotes to
T13061 8120-8126 VB denotes induce
T13062 8127-8139 NN denotes inflammation
T13063 8140-8142 FW denotes in
T13064 8143-8147 FW denotes vivo
T13065 8149-8156 RB denotes However
T13066 8156-8157 -COMMA- denotes ,
T13067 8158-8160 FW denotes in
T13068 8161-8165 FW denotes vivo
T13069 8165-8166 -COMMA- denotes ,
T13070 8167-8178 NN denotes macrophages
T13071 8179-8181 VB denotes do
T13072 8182-8185 RB denotes not
T13073 8186-8190 VB denotes come
T13074 8191-8193 IN denotes in
T13075 8194-8200 JJ denotes direct
T13076 8201-8208 NN denotes contact
T13077 8209-8213 IN denotes with
T13078 8214-8217 DT denotes the
T13079 8218-8228 JJ denotes intestinal
T13080 8229-8234 NN denotes lumen
T13081 8235-8238 CC denotes and
T13082 8239-8242 VB denotes are
T13083 8243-8252 VB denotes separated
T13084 8253-8255 IN denotes by
T13085 8256-8259 DT denotes the
T13086 8260-8270 JJ denotes epithelial
T13087 8271-8278 NN denotes barrier
T13088 8280-8283 DT denotes The
T13089 8284-8287 NN denotes way
T13090 8288-8290 IN denotes by
T13091 8291-8296 WDT denotes which
T13092 8297-8301 NN denotes dCGN
T13093 8302-8305 MD denotes may
T13094 8306-8311 VB denotes leave
T13095 8312-8315 DT denotes the
T13096 8316-8326 JJ denotes intestinal
T13097 8327-8332 NN denotes lumen
T13098 8333-8336 CC denotes and
T13099 8337-8342 VB denotes cross
T13100 8343-8346 DT denotes the
T13101 8347-8357 JJ denotes epithelial
T13102 8358-8365 NN denotes barrier
T13103 8366-8368 TO denotes to
T13104 8369-8374 VB denotes reach
T13105 8375-8378 DT denotes the
T13106 8379-8390 NN denotes macrophages
T13107 8391-8393 VB denotes is
T13108 8394-8396 DT denotes an
T13109 8397-8407 JJ denotes intriguing
T13110 8408-8412 JJ denotes open
T13111 8413-8421 NN denotes question
T13112 8423-8426 CD denotes One
T13113 8427-8435 JJ denotes possible
T13114 8436-8447 NN denotes explanation
T13115 8448-8455 VB denotes resides
T13116 8456-8458 IN denotes in
T13117 8459-8462 DT denotes the
T13118 8463-8472 NN denotes potential
T13119 8473-8475 IN denotes of
T13120 8476-8480 NN denotes dCGN
T13121 8481-8483 TO denotes to
T13122 8484-8492 VB denotes “induce”
T13123 8493-8501 JJ denotes cellular
T13124 8502-8505 CC denotes and
T13125 8506-8518 JJ denotes paracellular
T13126 8519-8528 JJ denotes injurious
T13127 8529-8536 NN denotes effects
T13128 8537-8539 IN denotes at
T13129 8540-8543 DT denotes the
T13130 8544-8554 JJ denotes intestinal
T13131 8555-8565 JJ denotes epithelial
T13132 8566-8570 NN denotes cell
T13133 8571-8580 NN denotes monolayer
T13134 8581-8582 -LRB- denotes [
T13135 8582-8584 CD denotes 48
T13136 8584-8585 -RRB- denotes ]
T13137 8587-8589 IN denotes In
T13138 8590-8600 NN denotes conclusion
T13139 8600-8601 -COMMA- denotes ,
T13140 8602-8606 NN denotes dCGN
T13141 8607-8616 VB denotes inhibited
T13142 8617-8622 NN denotes THP-1
T13143 8623-8627 NN denotes cell
T13144 8628-8641 NN denotes proliferation
T13145 8642-8644 FW denotes in
T13146 8645-8650 FW denotes vitro
T13147 8650-8651 -COMMA- denotes ,
T13148 8652-8664 VB denotes accumulating
T13149 8665-8668 DT denotes the
T13150 8669-8674 NN denotes cells
T13151 8675-8677 IN denotes in
T13152 8678-8681 DT denotes the
T13153 8682-8684 NN denotes G1
T13154 8685-8690 NN denotes phase
T13155 8691-8693 IN denotes of
T13156 8694-8697 DT denotes the
T13157 8698-8702 NN denotes cell
T13158 8703-8708 NN denotes cycle
T13159 8708-8709 -COMMA- denotes ,
T13160 8710-8719 VB denotes increased
T13161 8720-8726 NN denotes ICAM-1
T13162 8727-8737 NN denotes expression
T13163 8737-8738 -COMMA- denotes ,
T13164 8739-8749 VB denotes stimulated
T13165 8750-8766 JJ denotes ICAM-1-dependent
T13166 8767-8775 NN denotes monocyte
T13167 8776-8787 NN denotes aggregation
T13168 8788-8790 FW denotes in
T13169 8791-8796 FW denotes vitro
T13170 8796-8797 -COMMA- denotes ,
T13171 8798-8801 CC denotes and
T13172 8802-8812 VB denotes stimulated
T13173 8813-8818 NN denotes TNF-α
T13174 8819-8829 NN denotes expression
T13175 8830-8833 CC denotes and
T13176 8834-8843 NN denotes secretion
T13177 8845-8850 DT denotes These
T13178 8851-8860 NN denotes responses
T13179 8861-8865 VB denotes were
T13180 8866-8870 RB denotes more
T13181 8871-8881 JJ denotes pronounced
T13182 8882-8891 VB denotes following
T13183 8892-8894 CD denotes 40
T13184 8895-8898 NN denotes kDa
T13185 8899-8903 NN denotes dCGN
T13186 8903-8904 -COMMA- denotes ,
T13187 8905-8908 CC denotes and
T13188 8909-8913 VB denotes were
T13189 8914-8917 DT denotes all
T13190 8918-8924 VB denotes linked
T13191 8925-8927 TO denotes to
T13192 8928-8933 NN denotes NF-κB
T13193 8934-8944 NN denotes activation
T13194 8946-8951 DT denotes These
T13195 8952-8959 NN denotes results
T13196 8960-8967 VB denotes suggest
T13197 8968-8972 IN denotes that
T13198 8972-8973 -COMMA- denotes ,
T13199 8974-8982 IN denotes although
T13200 8983-8986 NN denotes CGN
T13201 8987-8989 VB denotes is
T13202 8990-8996 RB denotes widely
T13203 8997-9001 VB denotes used
T13204 9002-9004 IN denotes as
T13205 9005-9006 DT denotes a
T13206 9007-9011 NN denotes food
T13207 9012-9020 JJ denotes additive
T13208 9020-9021 -COMMA- denotes ,
T13209 9022-9025 PRP-DOLLAR- denotes its
T13210 9026-9034 JJ denotes degraded
T13211 9035-9040 NN denotes forms
T13212 9041-9045 VB denotes have
T13213 9046-9048 DT denotes an
T13214 9049-9058 JJ denotes important
T13215 9059-9065 NN denotes effect
T13216 9066-9068 IN denotes on
T13217 9069-9078 NN denotes monocytes
T13218 9079-9093 JJ denotes characteristic
T13219 9094-9096 IN denotes of
T13220 9097-9099 DT denotes an
T13221 9100-9112 JJ denotes inflammatory
T13222 9113-9122 NN denotes phenotype
R9790 T11641 T11642 arg1Of Inflammation,of
R9791 T11641 T11646 arg1Of Inflammation,is
R9792 T11641 T11648 arg2Of Inflammation,associated
R9793 T11645 T11642 arg2Of tract,of
R9794 T11645 T11643 arg1Of tract,the
R9795 T11645 T11644 arg1Of tract,intestinal
R9796 T11648 T11646 arg2Of associated,is
R9797 T11648 T11647 arg1Of associated,usually
R9798 T11648 T11649 arg1Of associated,with
R9799 T11648 T11656 arg1Of associated,[
R9800 T11650 T11651 arg1Of infiltration,and
R9801 T11651 T11649 arg2Of and,with
R9802 T11651 T11653 arg1Of and,of
R9803 T11652 T11651 arg2Of activation,and
R9804 T11655 T11653 arg2Of macrophages,of
R9805 T11655 T11654 arg1Of macrophages,intestinal
R9806 T11657 T11656 arg2Of 17,[
R9807 T11658 T11656 arg3Of ],[
R9808 T11660 T11659 arg1Of macrophages,These
R9809 T11660 T11661 arg1Of macrophages,are
R9810 T11660 T11662 arg1Of macrophages,able
R9811 T11660 T11664 arg1Of macrophages,initiate
R9812 T11660 T11668 arg1Of macrophages,can
R9813 T11660 T11669 arg1Of macrophages,be
R9814 T11660 T11670 arg2Of macrophages,induced
R9815 T11660 T11672 arg1Of macrophages,differentiate
R9816 T11660 T11679 arg1Of macrophages,inhibit
R9817 T11661 T11667 arg1Of are,and
R9818 T11662 T11661 arg2Of able,are
R9819 T11664 T11662 arg2Of initiate,able
R9820 T11664 T11663 arg1Of initiate,to
R9821 T11666 T11664 arg2Of responses,initiate
R9822 T11666 T11665 arg1Of responses,immune
R9823 T11670 T11667 arg2Of induced,and
R9824 T11670 T11668 arg2Of induced,can
R9825 T11670 T11669 arg2Of induced,be
R9826 T11672 T11673 arg1Of differentiate,into
R9827 T11672 T11678 arg1Of differentiate,or
R9828 T11677 T11673 arg2Of exacerbate,into
R9829 T11677 T11674 arg1Of exacerbate,cells
R9830 T11677 T11675 arg1Of exacerbate,that
R9831 T11677 T11676 arg1Of exacerbate,either
R9832 T11678 T11670 arg3Of or,induced
R9833 T11678 T11671 arg1Of or,to
R9834 T11679 T11678 arg2Of inhibit,or
R9835 T11681 T11679 arg2Of inflammation,inhibit
R9836 T11681 T11680 arg1Of inflammation,the
R9837 T11682 T11683 arg1Of Accumulation,of
R9838 T11682 T11703 arg1Of Accumulation,is
R9839 T11682 T11705 arg2Of Accumulation,followed
R9840 T11685 T11683 arg2Of types,of
R9841 T11685 T11684 arg1Of types,different
R9842 T11685 T11686 arg1Of types,of
R9843 T11685 T11688 arg1Of types,","
R9844 T11685 T11689 arg1Of types,including
R9845 T11687 T11686 arg2Of leukocytes,of
R9846 T11690 T11691 arg1Of monocytes/macrophages,","
R9847 T11691 T11694 arg1Of ",",and
R9848 T11692 T11691 arg2Of neutrophils,","
R9849 T11694 T11689 arg2Of and,including
R9850 T11694 T11693 arg1Of and,","
R9851 T11694 T11696 arg1Of and,in
R9852 T11694 T11700 arg1Of and,during
R9853 T11695 T11694 arg2Of lymphocytes,and
R9854 T11699 T11696 arg2Of mucosa,in
R9855 T11699 T11697 arg1Of mucosa,the
R9856 T11699 T11698 arg1Of mucosa,intestinal
R9857 T11701 T11700 arg2Of inflammation,during
R9858 T11705 T11702 arg1Of followed,","
R9859 T11705 T11703 arg2Of followed,is
R9860 T11705 T11704 arg1Of followed,normally
R9861 T11707 T11705 arg1Of secretion,followed
R9862 T11707 T11706 arg2Of secretion,by
R9863 T11707 T11708 arg1Of secretion,of
R9864 T11710 T11708 arg2Of cytokines,of
R9865 T11710 T11709 arg1Of cytokines,pro-inflammatory
R9866 T11710 T11711 arg1Of cytokines,[
R9867 T11712 T11711 arg2Of 33,[
R9868 T11713 T11711 arg3Of ],[
R9869 T11715 T11714 arg1Of stimuli,Several
R9870 T11715 T11716 arg1Of stimuli,can
R9871 T11715 T11717 arg1Of stimuli,induce
R9872 T11717 T11716 arg2Of induce,can
R9873 T11719 T11717 arg2Of leukocytes,induce
R9874 T11719 T11718 arg1Of leukocytes,these
R9875 T11719 T11721 arg1Of leukocytes,produce
R9876 T11721 T11717 arg3Of produce,induce
R9877 T11721 T11720 arg1Of produce,to
R9878 T11721 T11725 arg1Of produce,during
R9879 T11724 T11721 arg2Of cytokines,produce
R9880 T11724 T11722 arg1Of cytokines,and
R9881 T11724 T11723 arg1Of cytokines,secrete
R9882 T11726 T11725 arg2Of inflammation,during
R9883 T11727 T11728 arg1Of One,of
R9884 T11727 T11735 arg1Of One,for
R9885 T11727 T11738 arg1Of One,is
R9886 T11731 T11732 arg1Of potent,and
R9887 T11732 T11730 arg1Of and,most
R9888 T11733 T11732 arg2Of known,and
R9889 T11734 T11728 arg2Of stimuli,of
R9890 T11734 T11729 arg1Of stimuli,the
R9891 T11734 T11731 arg1Of stimuli,potent
R9892 T11734 T11733 arg1Of stimuli,known
R9893 T11737 T11735 arg2Of activation,for
R9894 T11737 T11736 arg1Of activation,leukocyte
R9895 T11738 T11743 arg1Of is,[
R9896 T11739 T11738 arg2Of LPS,is
R9897 T11739 T11740 arg1Of LPS,from
R9898 T11742 T11740 arg2Of bacteria,from
R9899 T11742 T11741 arg1Of bacteria,Gram-negative
R9900 T11744 T11743 arg2Of 34,[
R9901 T11745 T11743 arg3Of ],[
R9902 T11747 T11746 arg2Of addition,In
R9903 T11750 T11749 arg1Of factors,other
R9904 T11750 T11751 arg1Of factors,are
R9905 T11750 T11753 arg1Of factors,able
R9906 T11750 T11755 arg1Of factors,stimulate
R9907 T11751 T11746 arg1Of are,In
R9908 T11751 T11748 arg1Of are,","
R9909 T11751 T11752 arg1Of are,also
R9910 T11751 T11764 arg1Of are,","
R9911 T11751 T11765 arg1Of are,[
R9912 T11753 T11751 arg2Of able,are
R9913 T11755 T11753 arg2Of stimulate,able
R9914 T11755 T11754 arg1Of stimulate,to
R9915 T11757 T11755 arg2Of secretion,stimulate
R9916 T11757 T11756 arg1Of secretion,cytokine
R9917 T11757 T11758 arg1Of secretion,from
R9918 T11760 T11758 arg2Of leukocytes,from
R9919 T11760 T11759 arg1Of leukocytes,various
R9920 T11760 T11761 arg1Of leukocytes,[
R9921 T11762 T11761 arg2Of 35,[
R9922 T11763 T11761 arg3Of ],[
R9923 T11766 T11765 arg2Of 36,[
R9924 T11767 T11765 arg3Of ],[
R9925 T11770 T11768 arg1Of factor,One
R9926 T11770 T11769 arg1Of factor,such
R9927 T11770 T11771 arg1Of factor,is
R9928 T11771 T11789 arg1Of is,(
R9929 T11771 T11792 arg1Of is,[
R9930 T11771 T11795 arg1Of is,","
R9931 T11771 T11796 arg1Of is,[
R9932 T11772 T11771 arg2Of CGN,is
R9933 T11772 T11773 arg1Of CGN,","
R9934 T11777 T11773 arg2Of weight,","
R9935 T11777 T11774 arg1Of weight,a
R9936 T11777 T11775 arg1Of weight,high
R9937 T11777 T11776 arg1Of weight,molecular
R9938 T11777 T11778 arg2Of weight,sulphated
R9939 T11777 T11785 arg2Of weight,derived
R9940 T11779 T11778 arg3Of polysaccharide,sulphated
R9941 T11779 T11780 arg1Of polysaccharide,(
R9942 T11782 T11781 arg1Of 200,>
R9943 T11783 T11780 arg2Of kDa,(
R9944 T11783 T11782 arg1Of kDa,200
R9945 T11784 T11780 arg3Of ),(
R9946 T11785 T11786 arg1Of derived,from
R9947 T11788 T11786 arg2Of algae,from
R9948 T11788 T11787 arg1Of algae,red
R9949 T11790 T11789 arg2Of Rhodophyceae,(
R9950 T11791 T11789 arg3Of ),(
R9951 T11793 T11792 arg2Of 1,[
R9952 T11794 T11792 arg3Of ],[
R9953 T11797 T11796 arg2Of 2,[
R9954 T11798 T11796 arg3Of ],[
R9955 T11800 T11799 arg1Of CGN,Native
R9956 T11800 T11801 arg1Of CGN,is
R9957 T11800 T11803 arg2Of CGN,used
R9958 T11803 T11801 arg2Of used,is
R9959 T11803 T11802 arg1Of used,widely
R9960 T11803 T11804 arg1Of used,as
R9961 T11803 T11812 modOf used,to
R9962 T11809 T11804 arg2Of E,as
R9963 T11809 T11805 arg1Of E,a
R9964 T11809 T11806 arg1Of E,food
R9965 T11809 T11807 arg1Of E,additive
R9966 T11809 T11808 arg2Of E,(
R9967 T11809 T11810 arg1Of E,407
R9968 T11811 T11808 arg3Of ),(
R9969 T11813 T11812 arg1Of improve,to
R9970 T11814 T11813 arg2Of texture,improve
R9971 T11815 T11816 arg1Of It,is
R9972 T11815 T11818 arg2Of It,used
R9973 T11818 T11816 arg2Of used,is
R9974 T11818 T11817 arg1Of used,also
R9975 T11818 T11819 arg1Of used,in
R9976 T11820 T11821 arg1Of cosmetics,and
R9977 T11821 T11819 arg2Of and,in
R9978 T11822 T11821 arg2Of pharmaceuticals,and
R9979 T11826 T11824 arg1Of CGN,native
R9980 T11826 T11825 arg1Of CGN,form
R9981 T11826 T11827 arg1Of CGN,(
R9982 T11826 T11831 arg1Of CGN,has
R9983 T11826 T11832 arg1Of CGN,been
R9984 T11826 T11833 arg2Of CGN,declared
R9985 T11826 T11834 arg1Of CGN,harmless
R9986 T11829 T11827 arg2Of kDa,(
R9987 T11829 T11828 arg1Of kDa,200–800
R9988 T11830 T11827 arg3Of ),(
R9989 T11833 T11823 arg2Of declared,Although
R9990 T11833 T11831 arg2Of declared,has
R9991 T11833 T11832 arg2Of declared,been
R9992 T11834 T11833 arg3Of harmless,declared
R9993 T11834 T11835 arg1Of harmless,to
R9994 T11836 T11835 arg2Of humans,to
R9995 T11836 T11837 arg1Of humans,[
R9996 T11838 T11837 arg2Of 8,[
R9997 T11839 T11837 arg3Of ],[
R9998 T11843 T11841 arg1Of forms,its
R9999 T11843 T11842 arg1Of forms,degraded
R10000 T11843 T11844 arg1Of forms,(
R10001 T11843 T11849 arg1Of forms,","
R10002 T11843 T11851 arg2Of forms,known
R10003 T11843 T11855 arg1Of forms,are
R10004 T11843 T11857 arg2Of forms,used
R10005 T11843 T11859 arg1Of forms,induce
R10006 T11846 T11845 arg1Of 50,<
R10007 T11847 T11844 arg2Of kDa,(
R10008 T11847 T11846 arg1Of kDa,50
R10009 T11848 T11844 arg3Of ),(
R10010 T11851 T11850 arg1Of known,also
R10011 T11851 T11852 arg1Of known,as
R10012 T11853 T11852 arg2Of poligeenan,as
R10013 T11857 T11823 arg1Of used,Although
R10014 T11857 T11840 arg1Of used,","
R10015 T11857 T11854 arg1Of used,","
R10016 T11857 T11855 arg2Of used,are
R10017 T11857 T11856 arg1Of used,widely
R10018 T11859 T11857 arg3Of induce,used
R10019 T11859 T11858 arg1Of induce,to
R10020 T11860 T11859 arg2Of colitis,induce
R10021 T11860 T11861 arg1Of colitis,in
R10022 T11862 T11861 arg2Of rodents,in
R10023 T11862 T11863 arg1Of rodents,[
R10024 T11862 T11866 arg1Of rodents,–
R10025 T11862 T11867 arg1Of rodents,[
R10026 T11864 T11863 arg2Of 3,[
R10027 T11865 T11863 arg3Of ],[
R10028 T11868 T11867 arg2Of 5,[
R10029 T11869 T11867 arg3Of ],[
R10030 T11872 T11870 arg1Of CGN,These
R10031 T11872 T11871 arg2Of CGN,degraded
R10032 T11872 T11873 arg1Of CGN,may
R10033 T11872 T11875 arg1Of CGN,have
R10034 T11875 T11873 arg2Of have,may
R10035 T11875 T11874 arg1Of have,also
R10036 T11875 T11883 arg1Of have,","
R10037 T11875 T11884 arg1Of have,[
R10038 T11875 T11887 arg1Of have,–
R10039 T11875 T11890 arg1Of have,]
R10040 T11879 T11875 arg2Of effect,have
R10041 T11879 T11876 arg1Of effect,a
R10042 T11879 T11877 arg1Of effect,possible
R10043 T11879 T11878 arg1Of effect,carcinogenic
R10044 T11879 T11880 arg1Of effect,[
R10045 T11881 T11880 arg2Of 4,[
R10046 T11882 T11880 arg3Of ],[
R10047 T11885 T11884 arg2Of 6,[
R10048 T11886 T11884 arg3Of ],[
R10049 T11888 T11887 arg2Of [,–
R10050 T11889 T11887 arg3Of 8,–
R10051 T11892 T11893 arg1Of er t,hi
R10052 T11892 T11895 arg1Of er t,still controv
R10053 T11893 T11890 arg2Of hi,]
R10054 T11893 T11891 arg1Of hi,; howev
R10055 T11893 T11894 arg1Of hi,s is
R10056 T11895 T11893 arg2Of still controv,hi
R10057 T11898 T11897 arg1Of treatment,acid
R10058 T11898 T11899 arg1Of treatment,at
R10059 T11898 T11905 arg1Of treatment,is
R10060 T11898 T11906 arg2Of treatment,required
R10061 T11901 T11899 arg2Of temperature,at
R10062 T11901 T11900 arg1Of temperature,high
R10063 T11901 T11902 arg1Of temperature,(
R10064 T11903 T11902 arg2Of 80°C,(
R10065 T11904 T11902 arg3Of ),(
R10066 T11906 T11896 arg2Of required,Although
R10067 T11906 T11905 arg2Of required,is
R10068 T11906 T11907 arg1Of required,for
R10069 T11906 T11911 arg1Of required,vitro
R10070 T11906 T11912 modOf required,to
R10071 T11909 T11907 arg2Of hydrolysis,for
R10072 T11909 T11908 arg1Of hydrolysis,CGN
R10073 T11911 T11910 arg1Of vitro,in
R10074 T11913 T11912 arg1Of lower,to
R10075 T11916 T11913 arg2Of dCGN,lower
R10076 T11916 T11914 arg1Of dCGN,molecular
R10077 T11916 T11915 arg1Of dCGN,weight
R10078 T11919 T11896 arg1Of is,Although
R10079 T11919 T11917 arg1Of is,","
R10080 T11919 T11935 arg1Of is,","
R10081 T11919 T11947 arg1Of is,","
R10082 T11919 T11948 arg1Of is,[
R10083 T11920 T11919 arg2Of probable,is
R10084 T11923 T11922 arg1Of dCGN,some
R10085 T11923 T11924 arg1Of dCGN,are
R10086 T11923 T11925 arg2Of dCGN,produced
R10087 T11925 T11920 arg2Of produced,probable
R10088 T11925 T11921 arg1Of produced,that
R10089 T11925 T11924 arg2Of produced,are
R10090 T11925 T11929 arg1Of produced,during
R10091 T11928 T11925 arg1Of hydrolysis,produced
R10092 T11928 T11926 arg2Of hydrolysis,by
R10093 T11928 T11927 arg1Of hydrolysis,acid
R10094 T11931 T11929 arg2Of digestion,during
R10095 T11931 T11930 arg1Of digestion,gastric
R10096 T11931 T11932 arg1Of digestion,[
R10097 T11933 T11932 arg2Of 9,[
R10098 T11934 T11932 arg3Of ],[
R10099 T11937 T11936 arg2Of 10,[
R10100 T11937 T11939 arg1Of 10,or
R10101 T11938 T11936 arg3Of ],[
R10102 T11939 T11918 arg1Of or,it
R10103 T11939 T11919 arg1Of or,is
R10104 T11939 T11920 arg1Of or,probable
R10105 T11940 T11939 arg2Of interaction,or
R10106 T11940 T11941 arg1Of interaction,with
R10107 T11943 T11941 arg2Of bacteria,with
R10108 T11943 T11942 arg1Of bacteria,intestinal
R10109 T11943 T11944 arg1Of bacteria,[
R10110 T11945 T11944 arg2Of 11,[
R10111 T11946 T11944 arg3Of ],[
R10112 T11949 T11948 arg2Of 12,[
R10113 T11950 T11948 arg3Of ],[
R10114 T11953 T11960 arg1Of understanding,is
R10115 T11953 T11961 arg1Of understanding,of
R10116 T11955 T11953 arg2Of mechanisms,understanding
R10117 T11955 T11954 arg1Of mechanisms,the
R10118 T11955 T11956 arg1Of mechanisms,of
R10119 T11959 T11956 arg2Of inflammation,of
R10120 T11959 T11957 arg1Of inflammation,dCGN-induced
R10121 T11959 T11958 arg1Of inflammation,bowel
R10122 T11960 T11951 arg1Of is,Thus
R10123 T11960 T11952 arg1Of is,","
R10124 T11961 T11960 arg2Of of,is
R10125 T11963 T11961 arg2Of importance,of
R10126 T11963 T11962 arg1Of importance,great
R10127 T11966 T11964 arg2Of report,In
R10128 T11966 T11965 arg1Of report,this
R10129 T11968 T11969 arg1Of we,have
R10130 T11968 T11970 arg1Of we,analyzed
R10131 T11970 T11964 arg1Of analyzed,In
R10132 T11970 T11967 arg1Of analyzed,","
R10133 T11970 T11969 arg2Of analyzed,have
R10134 T11972 T11970 arg2Of role,analyzed
R10135 T11972 T11971 arg1Of role,the
R10136 T11972 T11973 arg1Of role,of
R10137 T11972 T11981 arg1Of role,in
R10138 T11975 T11973 arg2Of monocytes,of
R10139 T11975 T11974 arg1Of monocytes,human
R10140 T11975 T11976 arg1Of monocytes,(
R10141 T11977 T11978 arg1Of PBM,and
R10142 T11978 T11976 arg2Of and,(
R10143 T11979 T11978 arg2Of THP-1,and
R10144 T11980 T11976 arg3Of ),(
R10145 T11983 T11981 arg2Of inflammation,in
R10146 T11983 T11982 arg1Of inflammation,dCGN-induced
R10147 T11986 T11985 arg1Of vivo,in
R10148 T11987 T11984 arg1Of studies,Preliminary
R10149 T11987 T11986 arg1Of studies,vivo
R10150 T11987 T11988 arg1Of studies,in
R10151 T11987 T11993 arg1Of studies,revealed
R10152 T11989 T11988 arg2Of rats,in
R10153 T11989 T11990 arg2Of rats,treated
R10154 T11990 T11991 arg1Of treated,with
R10155 T11992 T11991 arg2Of dCGN,with
R10156 T11993 T12019 arg1Of revealed,[
R10157 T11995 T11993 arg2Of shortening,revealed
R10158 T11995 T11994 arg1Of shortening,significant
R10159 T11995 T11996 arg1Of shortening,of
R10160 T11995 T12015 arg1Of shortening,similar
R10161 T11999 T11996 arg2Of intestine,of
R10162 T11999 T11997 arg1Of intestine,the
R10163 T11999 T11998 arg1Of intestine,large
R10164 T11999 T12000 arg2Of intestine,associated
R10165 T11999 T12005 arg1Of intestine,","
R10166 T12000 T12001 arg1Of associated,with
R10167 T12004 T12001 arg2Of state,with
R10168 T12004 T12002 arg1Of state,an
R10169 T12004 T12003 arg1Of state,inflammatory
R10170 T12007 T12006 arg1Of strong,i.e.
R10171 T12008 T12005 arg2Of infiltration,","
R10172 T12008 T12007 arg1Of infiltration,strong
R10173 T12008 T12009 arg1Of infiltration,of
R10174 T12008 T12011 arg1Of infiltration,to
R10175 T12010 T12009 arg2Of macrophages,of
R10176 T12014 T12011 arg2Of mucosa,to
R10177 T12014 T12012 arg1Of mucosa,the
R10178 T12014 T12013 arg1Of mucosa,intestinal
R10179 T12015 T12016 arg1Of similar,to
R10180 T12018 T12016 arg2Of inflammation,to
R10181 T12018 T12017 arg1Of inflammation,DSS-induced
R10182 T12020 T12019 arg2Of 20,[
R10183 T12021 T12019 arg3Of ],[
R10184 T12024 T12022 arg2Of fractions,Using
R10185 T12024 T12023 arg1Of fractions,two
R10186 T12024 T12025 arg1Of fractions,of
R10187 T12026 T12025 arg2Of dCGN,of
R10188 T12026 T12027 arg1Of dCGN,(
R10189 T12028 T12029 arg1Of 10,and
R10190 T12030 T12029 arg2Of 40,and
R10191 T12031 T12027 arg2Of kDa,(
R10192 T12031 T12028 arg1Of kDa,10
R10193 T12031 T12030 arg1Of kDa,40
R10194 T12032 T12027 arg3Of ),(
R10195 T12034 T12022 arg1Of we,Using
R10196 T12034 T12035 arg1Of we,observed
R10197 T12034 T12052 arg1Of we,confirming
R10198 T12035 T12022 modOf observed,Using
R10199 T12035 T12033 arg1Of observed,","
R10200 T12035 T12050 arg1Of observed,","
R10201 T12035 T12052 modOf observed,confirming
R10202 T12038 T12035 arg2Of correlation,observed
R10203 T12038 T12036 arg1Of correlation,a
R10204 T12038 T12037 arg1Of correlation,strong
R10205 T12038 T12039 arg1Of correlation,between
R10206 T12041 T12039 arg2Of severity,between
R10207 T12041 T12040 arg1Of severity,the
R10208 T12041 T12042 arg1Of severity,of
R10209 T12044 T12043 arg1Of inflammation,the
R10210 T12044 T12045 arg1Of inflammation,and
R10211 T12045 T12042 arg2Of and,of
R10212 T12049 T12045 arg2Of size,and
R10213 T12049 T12046 arg1Of size,the
R10214 T12049 T12047 arg1Of size,dCGN
R10215 T12049 T12048 arg1Of size,molecular
R10216 T12052 T12051 arg1Of confirming,thus
R10217 T12056 T12052 arg2Of inflammation,confirming
R10218 T12056 T12053 arg1Of inflammation,the
R10219 T12056 T12054 arg1Of inflammation,size
R10220 T12056 T12055 arg1Of inflammation,related
R10221 T12056 T12058 arg1Of inflammation,vivo
R10222 T12058 T12057 arg1Of vivo,in
R10223 T12061 T12059 arg1Of accumulation,This
R10224 T12061 T12060 arg1Of accumulation,macrophage
R10225 T12061 T12062 arg1Of accumulation,was
R10226 T12061 T12064 arg1Of accumulation,due
R10227 T12062 T12063 arg1Of was,not
R10228 T12062 T12068 arg1Of was,because
R10229 T12064 T12062 arg2Of due,was
R10230 T12064 T12065 arg1Of due,to
R10231 T12067 T12065 arg2Of proliferation,to
R10232 T12067 T12066 arg1Of proliferation,cell
R10233 T12069 T12070 arg1Of dCGN,inhibited
R10234 T12070 T12068 arg2Of inhibited,because
R10235 T12070 T12075 arg1Of inhibited,vitro
R10236 T12073 T12070 arg2Of proliferation,inhibited
R10237 T12073 T12071 arg1Of proliferation,THP-1
R10238 T12073 T12072 arg1Of proliferation,monocytes
R10239 T12075 T12074 arg1Of vitro,in
R10240 T12077 T12076 arg1Of results,These
R10241 T12077 T12078 arg1Of results,are
R10242 T12077 T12079 arg1Of results,similar
R10243 T12079 T12078 arg2Of similar,are
R10244 T12079 T12080 arg1Of similar,to
R10245 T12081 T12080 arg2Of those,to
R10246 T12081 T12082 arg2Of those,obtained
R10247 T12082 T12083 arg1Of obtained,with
R10248 T12087 T12083 arg2Of cells,with
R10249 T12087 T12084 arg1Of cells,human
R10250 T12087 T12085 arg1Of cells,colonic
R10251 T12087 T12086 arg1Of cells,epithelial
R10252 T12087 T12088 arg1Of cells,(
R10253 T12087 T12093 arg2Of cells,exposed
R10254 T12091 T12088 arg2Of line,(
R10255 T12091 T12089 arg1Of line,NCM460
R10256 T12091 T12090 arg1Of line,cell
R10257 T12092 T12088 arg3Of ),(
R10258 T12093 T12094 arg1Of exposed,to
R10259 T12093 T12097 arg1Of exposed,for
R10260 T12096 T12094 arg2Of CGN,to
R10261 T12096 T12095 arg1Of CGN,native
R10262 T12099 T12097 arg2Of days,for
R10263 T12099 T12098 arg1Of days,1–8
R10264 T12099 T12100 arg1Of days,[
R10265 T12101 T12100 arg2Of 37,[
R10266 T12102 T12100 arg3Of ],[
R10267 T12105 T12106 arg1Of it,seems
R10268 T12106 T12103 arg1Of seems,Thus
R10269 T12106 T12104 arg1Of seems,","
R10270 T12108 T12109 arg1Of dCGN,promote
R10271 T12108 T12113 arg1Of dCGN,recruiting
R10272 T12109 T12106 arg2Of promote,seems
R10273 T12109 T12107 arg1Of promote,that
R10274 T12109 T12112 arg1Of promote,by
R10275 T12109 T12123 arg1Of promote,by
R10276 T12111 T12109 arg2Of infiltration,promote
R10277 T12111 T12110 arg1Of infiltration,macrophage
R10278 T12112 T12121 arg1Of by,and
R10279 T12113 T12112 arg2Of recruiting,by
R10280 T12115 T12113 arg2Of cells,recruiting
R10281 T12115 T12114 arg1Of cells,new
R10282 T12115 T12116 arg1Of cells,to
R10283 T12120 T12116 arg2Of mucosa,to
R10284 T12120 T12117 arg1Of mucosa,the
R10285 T12120 T12118 arg1Of mucosa,inflamed
R10286 T12120 T12119 arg1Of mucosa,intestinal
R10287 T12123 T12121 arg2Of by,and
R10288 T12123 T12122 arg1Of by,not
R10289 T12124 T12123 arg2Of inducing,by
R10290 T12126 T12124 arg2Of proliferation,inducing
R10291 T12126 T12125 arg1Of proliferation,cell
R10292 T12128 T12127 arg2Of addition,In
R10293 T12131 T12130 arg1Of few,very
R10294 T12133 T12131 arg1Of cells,few
R10295 T12133 T12132 arg1Of cells,polymorphonuclear
R10296 T12133 T12134 arg1Of cells,were
R10297 T12133 T12135 arg2Of cells,detected
R10298 T12135 T12127 arg1Of detected,In
R10299 T12135 T12129 arg1Of detected,","
R10300 T12135 T12134 arg2Of detected,were
R10301 T12135 T12136 arg1Of detected,in
R10302 T12135 T12139 arg1Of detected,at
R10303 T12138 T12136 arg2Of mucosa,in
R10304 T12138 T12137 arg1Of mucosa,the
R10305 T12142 T12139 arg2Of point,at
R10306 T12142 T12140 arg1Of point,the
R10307 T12142 T12141 arg1Of point,time
R10308 T12142 T12143 arg2Of point,analyzed
R10309 T12143 T12144 arg1Of analyzed,as
R10310 T12145 T12144 arg2Of demonstrated,as
R10311 T12149 T12148 arg1Of low,very
R10312 T12150 T12145 arg1Of level,demonstrated
R10313 T12150 T12146 arg2Of level,by
R10314 T12150 T12147 arg1Of level,a
R10315 T12150 T12149 arg1Of level,low
R10316 T12150 T12151 arg1Of level,of
R10317 T12150 T12153 arg1Of level,in
R10318 T12152 T12151 arg2Of MPO,of
R10319 T12156 T12153 arg2Of tissue,in
R10320 T12156 T12154 arg1Of tissue,the
R10321 T12156 T12155 arg1Of tissue,intestinal
R10322 T12158 T12157 arg1Of results,These
R10323 T12158 T12159 arg1Of results,suggest
R10324 T12161 T12162 arg1Of monocytes,might
R10325 T12161 T12163 arg1Of monocytes,produce
R10326 T12163 T12159 arg2Of produce,suggest
R10327 T12163 T12160 arg1Of produce,that
R10328 T12163 T12162 arg2Of produce,might
R10329 T12164 T12163 arg2Of cytokines,produce
R10330 T12164 T12165 arg2Of cytokines,associated
R10331 T12165 T12166 arg1Of associated,with
R10332 T12167 T12166 arg2Of activation,with
R10333 T12167 T12168 arg1Of activation,into
R10334 T12169 T12168 arg2Of macrophages,into
R10335 T12169 T12170 arg1Of macrophages,in
R10336 T12171 T12170 arg2Of response,in
R10337 T12171 T12172 arg1Of response,to
R10338 T12173 T12172 arg2Of dCGN,to
R10339 T12176 T12177 arg1Of we,analyzed
R10340 T12177 T12174 arg1Of analyzed,Thus
R10341 T12177 T12175 arg1Of analyzed,","
R10342 T12177 T12188 arg1Of analyzed,in
R10343 T12179 T12177 arg2Of production,analyzed
R10344 T12179 T12178 arg1Of production,the
R10345 T12179 T12180 arg1Of production,of
R10346 T12179 T12182 arg1Of production,by
R10347 T12181 T12180 arg2Of TNF,of
R10348 T12184 T12185 arg1Of PBM,and
R10349 T12185 T12182 arg2Of and,by
R10350 T12185 T12183 arg1Of and,both
R10351 T12187 T12185 arg2Of cells,and
R10352 T12187 T12186 arg1Of cells,THP-1
R10353 T12188 T12190 arg1Of in,to
R10354 T12189 T12188 arg2Of response,in
R10355 T12191 T12188 arg3Of dCGN,in
R10356 T12193 T12192 arg2Of CGN,Degraded
R10357 T12193 T12194 arg1Of CGN,induced
R10358 T12197 T12194 arg2Of production,induced
R10359 T12197 T12195 arg1Of production,a
R10360 T12197 T12196 arg1Of production,robust
R10361 T12197 T12198 arg1Of production,of
R10362 T12197 T12200 arg1Of production,by
R10363 T12199 T12198 arg2Of TNF,of
R10364 T12201 T12200 arg2Of monocytes,by
R10365 T12203 T12204 arg1Of 40,kDa
R10366 T12205 T12202 arg1Of form,The
R10367 T12205 T12203 arg1Of form,40
R10368 T12205 T12206 arg1Of form,of
R10369 T12205 T12208 arg1Of form,was
R10370 T12205 T12210 arg1Of form,potent
R10371 T12207 T12206 arg2Of dCGN,of
R10372 T12210 T12208 arg2Of potent,was
R10373 T12210 T12209 arg1Of potent,more
R10374 T12210 T12211 arg1Of potent,for
R10375 T12210 T12214 arg1Of potent,than
R10376 T12213 T12211 arg2Of stimulation,for
R10377 T12213 T12212 arg1Of stimulation,monocyte
R10378 T12217 T12215 arg1Of kDa,the
R10379 T12217 T12216 arg1Of kDa,10
R10380 T12217 T12218 arg1Of kDa,or
R10381 T12218 T12214 arg2Of or,than
R10382 T12221 T12218 arg2Of ones,or
R10383 T12221 T12219 arg1Of ones,the
R10384 T12221 T12220 arg1Of ones,native
R10385 T12225 T12224 arg1Of activation,monocyte
R10386 T12225 T12226 arg1Of activation,by
R10387 T12225 T12231 arg1Of activation,was
R10388 T12225 T12233 arg1Of activation,stronger
R10389 T12227 T12226 arg2Of dCGN,by
R10390 T12227 T12228 modOf dCGN,to
R10391 T12229 T12228 arg1Of produce,to
R10392 T12230 T12229 arg2Of TNF,produce
R10393 T12231 T12222 arg1Of was,Surprisingly
R10394 T12231 T12223 arg1Of was,","
R10395 T12233 T12231 arg2Of stronger,was
R10396 T12233 T12232 arg1Of stronger,much
R10397 T12233 T12234 arg1Of stronger,than
R10398 T12236 T12234 arg2Of activation,than
R10399 T12236 T12235 arg1Of activation,the
R10400 T12236 T12237 arg2Of activation,induced
R10401 T12239 T12237 arg1Of LPS,induced
R10402 T12239 T12238 arg2Of LPS,by
R10403 T12239 T12240 arg1Of LPS,","
R10404 T12243 T12240 arg2Of factor,","
R10405 T12243 T12241 arg1Of factor,an
R10406 T12243 T12242 arg1Of factor,inflammatory
R10407 T12243 T12244 arg2Of factor,considered
R10408 T12243 T12246 arg1Of factor,be
R10409 T12243 T12247 arg1Of factor,among
R10410 T12246 T12244 arg3Of be,considered
R10411 T12246 T12245 arg1Of be,to
R10412 T12247 T12246 arg2Of among,be
R10413 T12250 T12249 arg1Of potent,most
R10414 T12251 T12247 arg2Of stimuli,among
R10415 T12251 T12248 arg1Of stimuli,the
R10416 T12251 T12250 arg1Of stimuli,potent
R10417 T12251 T12252 arg1Of stimuli,for
R10418 T12254 T12252 arg2Of activation,for
R10419 T12254 T12253 arg1Of activation,leukocyte
R10420 T12256 T12255 arg1Of results,These
R10421 T12256 T12257 arg1Of results,underline
R10422 T12259 T12257 arg2Of fact,underline
R10423 T12259 T12258 arg1Of fact,the
R10424 T12263 T12261 arg1Of forms,partially
R10425 T12263 T12262 arg2Of forms,degraded
R10426 T12263 T12264 arg1Of forms,of
R10427 T12263 T12266 arg1Of forms,have
R10428 T12265 T12264 arg2Of CGN,of
R10429 T12266 T12259 arg2Of have,fact
R10430 T12266 T12260 arg1Of have,that
R10431 T12269 T12266 arg2Of effects,have
R10432 T12269 T12267 arg1Of effects,important
R10433 T12269 T12268 arg1Of effects,cellular
R10434 T12271 T12270 arg1Of amount,The
R10435 T12271 T12272 arg1Of amount,of
R10436 T12271 T12280 arg1Of amount,was
R10437 T12271 T12282 arg1Of amount,larger
R10438 T12273 T12272 arg2Of TNF,of
R10439 T12273 T12274 arg2Of TNF,secreted
R10440 T12276 T12274 arg1Of PBM,secreted
R10441 T12276 T12275 arg2Of PBM,by
R10442 T12276 T12277 arg2Of PBM,induced
R10443 T12277 T12278 arg1Of induced,with
R10444 T12279 T12278 arg2Of LPS,with
R10445 T12282 T12280 arg2Of larger,was
R10446 T12282 T12281 arg1Of larger,much
R10447 T12282 T12283 arg1Of larger,than
R10448 T12285 T12283 arg2Of one,than
R10449 T12285 T12284 arg1Of one,the
R10450 T12285 T12286 arg2Of one,secreted
R10451 T12289 T12286 arg1Of monocytes,secreted
R10452 T12289 T12287 arg2Of monocytes,by
R10453 T12289 T12288 arg1Of monocytes,THP-1
R10454 T12292 T12291 arg1Of activation,monocyte
R10455 T12292 T12293 arg1Of activation,by
R10456 T12292 T12295 arg1Of activation,is
R10457 T12292 T12296 arg2Of activation,associated
R10458 T12294 T12293 arg2Of LPS,by
R10459 T12296 T12290 arg2Of associated,Since
R10460 T12296 T12295 arg2Of associated,is
R10461 T12296 T12297 arg1Of associated,with
R10462 T12299 T12297 arg2Of presence,with
R10463 T12299 T12298 arg1Of presence,the
R10464 T12299 T12300 arg1Of presence,of
R10465 T12302 T12303 arg1Of CD14,and
R10466 T12304 T12303 arg2Of TLR4,and
R10467 T12307 T12306 arg2Of 38,[
R10468 T12308 T12306 arg3Of ],[
R10469 T12309 T12300 arg2Of –,of
R10470 T12309 T12301 arg1Of –,the
R10471 T12309 T12302 arg1Of –,CD14
R10472 T12309 T12304 arg1Of –,TLR4
R10473 T12309 T12305 arg1Of –,receptors
R10474 T12309 T12306 arg1Of –,[
R10475 T12309 T12310 arg1Of –,[
R10476 T12311 T12310 arg2Of 40,[
R10477 T12312 T12310 arg3Of ],[
R10478 T12316 T12314 arg1Of response,the
R10479 T12316 T12315 arg1Of response,different
R10480 T12316 T12317 arg2Of response,observed
R10481 T12316 T12318 arg1Of response,could
R10482 T12316 T12319 arg1Of response,be
R10483 T12316 T12321 arg1Of response,to
R10484 T12319 T12290 arg1Of be,Since
R10485 T12319 T12313 arg1Of be,","
R10486 T12319 T12318 arg2Of be,could
R10487 T12321 T12319 arg2Of to,be
R10488 T12321 T12320 arg1Of to,due
R10489 T12324 T12321 arg2Of expression,to
R10490 T12324 T12322 arg1Of expression,the
R10491 T12324 T12323 arg1Of expression,different
R10492 T12324 T12325 arg1Of expression,of
R10493 T12324 T12328 arg1Of expression,in
R10494 T12327 T12325 arg2Of receptors,of
R10495 T12327 T12326 arg1Of receptors,these
R10496 T12329 T12330 arg1Of PBM,and
R10497 T12330 T12328 arg2Of and,in
R10498 T12332 T12330 arg2Of cells,and
R10499 T12332 T12331 arg1Of cells,THP-1
R10500 T12333 T12334 arg1Of CD14,is
R10501 T12333 T12336 arg2Of CD14,expressed
R10502 T12336 T12334 arg2Of expressed,is
R10503 T12336 T12335 arg1Of expressed,not
R10504 T12336 T12341 arg1Of expressed,but
R10505 T12339 T12336 arg1Of monocytes,expressed
R10506 T12339 T12337 arg2Of monocytes,by
R10507 T12339 T12338 arg1Of monocytes,THP-1
R10508 T12341 T12340 arg1Of but,","
R10509 T12342 T12343 arg1Of it,is
R10510 T12342 T12344 arg2Of it,expressed
R10511 T12344 T12341 arg2Of expressed,but
R10512 T12344 T12343 arg2Of expressed,is
R10513 T12346 T12344 arg1Of PBM,expressed
R10514 T12346 T12345 arg2Of PBM,by
R10515 T12348 T12347 arg1Of fact,This
R10516 T12348 T12349 arg1Of fact,could
R10517 T12348 T12350 arg1Of fact,explain
R10518 T12350 T12349 arg2Of explain,could
R10519 T12351 T12350 arg2Of why,explain
R10520 T12353 T12352 arg1Of cells,THP-1
R10521 T12353 T12354 arg1Of cells,produced
R10522 T12354 T12351 arg1Of produced,why
R10523 T12354 T12369 arg1Of produced,in
R10524 T12357 T12356 arg1Of smaller,much
R10525 T12358 T12355 arg1Of response,a
R10526 T12358 T12357 arg1Of response,smaller
R10527 T12358 T12359 arg1Of response,to
R10528 T12358 T12361 arg1Of response,than
R10529 T12358 T12363 arg1Of response,and
R10530 T12360 T12359 arg2Of LPS,to
R10531 T12362 T12361 arg2Of PBM,than
R10532 T12363 T12354 arg2Of and,produced
R10533 T12366 T12363 arg2Of difference,and
R10534 T12366 T12364 arg1Of difference,also
R10535 T12366 T12365 arg1Of difference,the
R10536 T12366 T12367 arg1Of difference,of
R10537 T12368 T12367 arg2Of kinetics,of
R10538 T12371 T12370 arg1Of LPS,the
R10539 T12371 T12372 arg1Of LPS,induced
R10540 T12372 T12369 arg2Of induced,in
R10541 T12374 T12372 arg2Of secretion,induced
R10542 T12374 T12373 arg1Of secretion,TNF
R10543 T12376 T12375 arg1Of peak,The
R10544 T12376 T12377 arg1Of peak,of
R10545 T12376 T12380 arg1Of peak,was
R10546 T12376 T12381 arg2Of peak,observed
R10547 T12379 T12377 arg2Of response,of
R10548 T12379 T12378 arg1Of response,TNF
R10549 T12381 T12380 arg2Of observed,was
R10550 T12381 T12382 arg1Of observed,after
R10551 T12381 T12397 arg1Of observed,whereas
R10552 T12385 T12382 arg2Of stimulation,after
R10553 T12385 T12383 arg1Of stimulation,8
R10554 T12385 T12384 arg1Of stimulation,h
R10555 T12385 T12386 arg2Of stimulation,followed
R10556 T12390 T12386 arg1Of decrease,followed
R10557 T12390 T12387 arg2Of decrease,by
R10558 T12390 T12388 arg1Of decrease,a
R10559 T12390 T12389 arg1Of decrease,rapid
R10560 T12390 T12391 arg1Of decrease,to
R10561 T12390 T12393 arg1Of decrease,at
R10562 T12392 T12391 arg2Of baseline,to
R10563 T12395 T12393 arg2Of h,at
R10564 T12395 T12394 arg1Of h,10
R10565 T12397 T12396 arg1Of whereas,","
R10566 T12400 T12398 arg2Of cells,on
R10567 T12400 T12399 arg1Of cells,THP-1
R10568 T12402 T12401 arg1Of peak,the
R10569 T12402 T12403 arg1Of peak,was
R10570 T12402 T12405 arg2Of peak,reached
R10571 T12405 T12397 arg2Of reached,whereas
R10572 T12405 T12398 arg1Of reached,on
R10573 T12405 T12403 arg2Of reached,was
R10574 T12405 T12404 arg1Of reached,not
R10575 T12405 T12407 arg1Of reached,after
R10576 T12407 T12406 arg1Of after,until
R10577 T12409 T12407 arg2Of h,after
R10578 T12409 T12408 arg1Of h,56
R10579 T12413 T12412 arg1Of amount,the
R10580 T12413 T12414 arg1Of amount,of
R10581 T12413 T12422 arg1Of amount,was
R10582 T12413 T12424 arg1Of amount,larger
R10583 T12415 T12414 arg2Of TNF,of
R10584 T12415 T12416 arg2Of TNF,secreted
R10585 T12418 T12416 arg1Of monocytes,secreted
R10586 T12418 T12417 arg2Of monocytes,by
R10587 T12418 T12419 arg2Of monocytes,induced
R10588 T12419 T12420 arg1Of induced,with
R10589 T12421 T12420 arg2Of dCGN,with
R10590 T12422 T12410 arg1Of was,Moreover
R10591 T12422 T12411 arg1Of was,","
R10592 T12424 T12422 arg2Of larger,was
R10593 T12424 T12423 arg1Of larger,much
R10594 T12424 T12425 arg1Of larger,than
R10595 T12427 T12425 arg2Of one,than
R10596 T12427 T12426 arg1Of one,the
R10597 T12427 T12428 arg2Of one,induced
R10598 T12430 T12428 arg1Of LPS,induced
R10599 T12430 T12429 arg2Of LPS,by
R10600 T12434 T12431 arg2Of hand,On
R10601 T12434 T12432 arg1Of hand,the
R10602 T12434 T12433 arg1Of hand,other
R10603 T12436 T12437 arg1Of LPS,and
R10604 T12437 T12439 arg1Of and,displayed
R10605 T12438 T12437 arg2Of dCGN,and
R10606 T12439 T12431 arg1Of displayed,On
R10607 T12439 T12435 arg1Of displayed,","
R10608 T12442 T12441 arg1Of different,very
R10609 T12445 T12439 arg2Of curve,displayed
R10610 T12445 T12440 arg1Of curve,a
R10611 T12445 T12442 arg1Of curve,different
R10612 T12445 T12443 arg1Of curve,TNF
R10613 T12445 T12444 arg1Of curve,secretion
R10614 T12445 T12446 arg1Of curve,in
R10615 T12448 T12446 arg2Of cells,in
R10616 T12448 T12447 arg1Of cells,THP-1
R10617 T12450 T12449 arg1Of differences,These
R10618 T12450 T12451 arg1Of differences,suggest
R10619 T12453 T12454 arg1Of dCGN,and
R10620 T12454 T12456 arg1Of and,could
R10621 T12454 T12457 arg1Of and,use
R10622 T12455 T12454 arg2Of LPS,and
R10623 T12457 T12451 arg2Of use,suggest
R10624 T12457 T12452 arg1Of use,that
R10625 T12457 T12456 arg2Of use,could
R10626 T12460 T12457 arg2Of mechanisms,use
R10627 T12460 T12458 arg1Of mechanisms,different
R10628 T12460 T12459 arg1Of mechanisms,activation
R10629 T12463 T12462 arg2Of noteworthy,is
R10630 T12465 T12467 arg1Of neutralizing,to
R10631 T12465 T12470 arg1Of neutralizing,partially
R10632 T12465 T12476 arg1Of neutralizing,inhibited
R10633 T12466 T12465 arg2Of antibody,neutralizing
R10634 T12468 T12467 arg2Of CD14,to
R10635 T12470 T12469 arg1Of partially,only
R10636 T12470 T12471 arg1Of partially,(
R10637 T12473 T12472 arg1Of 40,<
R10638 T12474 T12471 arg2Of %,(
R10639 T12474 T12473 arg1Of %,40
R10640 T12475 T12471 arg3Of ),(
R10641 T12476 T12461 arg1Of inhibited,It
R10642 T12476 T12462 arg1Of inhibited,is
R10643 T12476 T12463 arg1Of inhibited,noteworthy
R10644 T12476 T12464 arg1Of inhibited,that
R10645 T12479 T12476 arg2Of secretion,inhibited
R10646 T12479 T12477 arg1Of secretion,dCGN-induced
R10647 T12479 T12478 arg1Of secretion,TNF
R10648 T12479 T12480 arg1Of secretion,(
R10649 T12482 T12480 arg2Of shown,(
R10650 T12482 T12481 arg1Of shown,not
R10651 T12483 T12480 arg3Of ),(
R10652 T12484 T12485 arg1Of TLR4,has
R10653 T12484 T12486 arg1Of TLR4,been
R10654 T12484 T12488 arg2Of TLR4,identified
R10655 T12488 T12485 arg2Of identified,has
R10656 T12488 T12486 arg2Of identified,been
R10657 T12488 T12487 arg1Of identified,recently
R10658 T12488 T12489 arg1Of identified,as
R10659 T12493 T12489 arg2Of receptor,as
R10660 T12493 T12490 arg1Of receptor,a
R10661 T12493 T12491 arg1Of receptor,surface
R10662 T12493 T12492 arg1Of receptor,membrane
R10663 T12493 T12494 arg1Of receptor,for
R10664 T12493 T12496 arg1Of receptor,in
R10665 T12495 T12494 arg2Of CGN,for
R10666 T12500 T12496 arg2Of cells,in
R10667 T12500 T12497 arg1Of cells,human
R10668 T12500 T12498 arg1Of cells,colonic
R10669 T12500 T12499 arg1Of cells,epithelial
R10670 T12500 T12501 arg1Of cells,[
R10671 T12502 T12501 arg2Of 41,[
R10672 T12503 T12501 arg3Of ],[
R10673 T12507 T12504 arg1Of is,Thus
R10674 T12507 T12505 arg1Of is,","
R10675 T12508 T12507 arg2Of possible,is
R10676 T12510 T12511 arg1Of TLR4,is
R10677 T12510 T12512 arg2Of TLR4,activated
R10678 T12512 T12506 arg1Of activated,it
R10679 T12512 T12507 arg1Of activated,is
R10680 T12512 T12508 arg1Of activated,possible
R10681 T12512 T12509 arg1Of activated,that
R10682 T12512 T12511 arg2Of activated,is
R10683 T12512 T12515 modOf activated,to
R10684 T12514 T12512 arg1Of dCGN,activated
R10685 T12514 T12513 arg2Of dCGN,by
R10686 T12516 T12515 arg1Of induce,to
R10687 T12518 T12516 arg2Of secretion,induce
R10688 T12518 T12517 arg1Of secretion,cytokine
R10689 T12518 T12519 arg1Of secretion,by
R10690 T12520 T12519 arg2Of monocytes,by
R10691 T12521 T12522 arg1Of We,can
R10692 T12521 T12524 arg1Of We,speculate
R10693 T12524 T12522 arg2Of speculate,can
R10694 T12524 T12523 arg1Of speculate,only
R10695 T12524 T12538 arg1Of speculate,","
R10696 T12526 T12527 arg1Of TLR4,may
R10697 T12526 T12528 arg1Of TLR4,have
R10698 T12528 T12524 arg2Of have,speculate
R10699 T12528 T12525 arg1Of have,that
R10700 T12528 T12527 arg2Of have,may
R10701 T12532 T12528 arg2Of site,have
R10702 T12532 T12529 arg1Of site,a
R10703 T12532 T12530 arg1Of site,higher
R10704 T12532 T12531 arg1Of site,affinity-binding
R10705 T12532 T12533 arg1Of site,for
R10706 T12532 T12535 arg1Of site,than
R10707 T12534 T12533 arg2Of dCGN,for
R10708 T12536 T12535 arg2Of for,than
R10709 T12537 T12536 arg2Of LPS,for
R10710 T12542 T12541 arg1Of hypothesis,this
R10711 T12542 T12543 arg1Of hypothesis,remains
R10712 T12542 T12545 arg1Of hypothesis,be
R10713 T12542 T12546 arg2Of hypothesis,tested
R10714 T12543 T12538 arg2Of remains,","
R10715 T12543 T12539 arg1Of remains,however
R10716 T12543 T12540 arg1Of remains,","
R10717 T12546 T12543 arg2Of tested,remains
R10718 T12546 T12544 arg1Of tested,to
R10719 T12546 T12545 arg2Of tested,be
R10720 T12548 T12547 arg1Of indicator,Another
R10721 T12548 T12559 arg1Of indicator,is
R10722 T12550 T12551 arg1Of dCGN,stimulate
R10723 T12551 T12548 arg2Of stimulate,indicator
R10724 T12551 T12549 arg1Of stimulate,that
R10725 T12552 T12551 arg2Of monocytes,stimulate
R10726 T12552 T12553 arg1Of monocytes,leading
R10727 T12553 T12554 arg1Of leading,to
R10728 T12557 T12556 arg1Of active,more
R10729 T12558 T12554 arg2Of phenotype,to
R10730 T12558 T12555 arg1Of phenotype,a
R10731 T12558 T12557 arg1Of phenotype,active
R10732 T12561 T12559 arg2Of fact,is
R10733 T12561 T12560 arg1Of fact,the
R10734 T12564 T12563 arg1Of expression,surface
R10735 T12564 T12565 arg1Of expression,of
R10736 T12564 T12570 arg1Of expression,was
R10737 T12564 T12571 arg2Of expression,enhanced
R10738 T12569 T12565 arg2Of ICAM-1,of
R10739 T12569 T12566 arg1Of ICAM-1,the
R10740 T12569 T12567 arg1Of ICAM-1,adhesion
R10741 T12569 T12568 arg1Of ICAM-1,molecule
R10742 T12571 T12561 arg2Of enhanced,fact
R10743 T12571 T12562 arg1Of enhanced,that
R10744 T12571 T12570 arg2Of enhanced,was
R10745 T12571 T12572 arg1Of enhanced,in
R10746 T12574 T12575 arg1Of PBM,and
R10747 T12575 T12572 arg2Of and,in
R10748 T12575 T12573 arg1Of and,both
R10749 T12577 T12575 arg2Of cells,and
R10750 T12577 T12576 arg1Of cells,THP-1
R10751 T12580 T12578 arg1Of expression,The
R10752 T12580 T12579 arg1Of expression,over
R10753 T12580 T12581 arg1Of expression,of
R10754 T12580 T12583 arg1Of expression,caused
R10755 T12582 T12581 arg2Of ICAM-1,of
R10756 T12586 T12583 arg2Of monocytes,caused
R10757 T12586 T12584 arg1Of monocytes,the
R10758 T12586 T12585 arg2Of monocytes,activated
R10759 T12586 T12588 arg1Of monocytes,form
R10760 T12588 T12583 arg3Of form,caused
R10761 T12588 T12587 arg1Of form,to
R10762 T12590 T12588 arg2Of aggregates,form
R10763 T12590 T12589 arg1Of aggregates,cell
R10764 T12590 T12591 arg1Of aggregates,that
R10765 T12590 T12592 arg1Of aggregates,were
R10766 T12590 T12594 arg1Of aggregates,abundant
R10767 T12592 T12595 arg1Of were,among
R10768 T12594 T12592 arg2Of abundant,were
R10769 T12594 T12593 arg1Of abundant,more
R10770 T12596 T12595 arg2Of cells,among
R10771 T12596 T12597 arg2Of cells,treated
R10772 T12597 T12598 arg1Of treated,with
R10773 T12602 T12598 arg2Of dCGN,with
R10774 T12602 T12599 arg1Of dCGN,the
R10775 T12602 T12600 arg1Of dCGN,40
R10776 T12602 T12601 arg1Of dCGN,kDa
R10777 T12603 T12604 arg1Of This,correlates
R10778 T12604 T12605 arg1Of correlates,with
R10779 T12608 T12605 arg2Of expression,with
R10780 T12608 T12606 arg1Of expression,the
R10781 T12608 T12607 arg1Of expression,higher
R10782 T12608 T12609 arg1Of expression,of
R10783 T12610 T12609 arg2Of ICAM-1,of
R10784 T12610 T12611 arg2Of ICAM-1,induced
R10785 T12611 T12617 arg1Of induced,","
R10786 T12611 T12618 modOf induced,suggesting
R10787 T12616 T12611 arg1Of dCGN,induced
R10788 T12616 T12612 arg2Of dCGN,by
R10789 T12616 T12613 arg1Of dCGN,the
R10790 T12616 T12614 arg1Of dCGN,40
R10791 T12616 T12615 arg1Of dCGN,kDa
R10792 T12623 T12620 arg1Of CGN,the
R10793 T12623 T12621 arg1Of CGN,partially
R10794 T12623 T12622 arg2Of CGN,degraded
R10795 T12623 T12624 arg1Of CGN,is
R10796 T12623 T12627 arg1Of CGN,active
R10797 T12624 T12618 arg2Of is,suggesting
R10798 T12624 T12619 arg1Of is,that
R10799 T12626 T12625 arg1Of biologically,more
R10800 T12627 T12624 arg2Of active,is
R10801 T12627 T12626 arg1Of active,biologically
R10802 T12629 T12628 arg2Of addition,In
R10803 T12633 T12631 arg1Of aggregates,the
R10804 T12633 T12632 arg1Of aggregates,cell
R10805 T12633 T12634 arg1Of aggregates,are
R10806 T12633 T12635 arg1Of aggregates,reminiscent
R10807 T12634 T12628 arg1Of are,In
R10808 T12634 T12630 arg1Of are,","
R10809 T12635 T12634 arg2Of reminiscent,are
R10810 T12635 T12636 arg1Of reminiscent,of
R10811 T12638 T12636 arg2Of aggregates,of
R10812 T12638 T12637 arg1Of aggregates,monocyte
R10813 T12638 T12639 arg1Of aggregates,","
R10814 T12638 T12640 arg1Of aggregates,which
R10815 T12638 T12641 arg1Of aggregates,form
R10816 T12644 T12641 arg2Of cells,form
R10817 T12644 T12642 arg1Of cells,multinucleated
R10818 T12644 T12643 arg1Of cells,giant
R10819 T12644 T12645 arg1Of cells,(
R10820 T12644 T12648 arg1Of cells,in
R10821 T12646 T12645 arg2Of MGC,(
R10822 T12647 T12645 arg3Of ),(
R10823 T12649 T12648 arg2Of patients,in
R10824 T12649 T12650 arg1Of patients,with
R10825 T12652 T12650 arg2Of 's,with
R10826 T12652 T12651 arg1Of 's,Crohn
R10827 T12652 T12653 arg1Of 's,disease
R10828 T12652 T12654 arg1Of 's,[
R10829 T12655 T12654 arg2Of 42,[
R10830 T12656 T12654 arg3Of ],[
R10831 T12659 T12657 arg1Of cells,These
R10832 T12659 T12658 arg1Of cells,giant
R10833 T12659 T12660 arg1Of cells,were
R10834 T12659 T12662 arg2Of cells,observed
R10835 T12662 T12660 arg2Of observed,were
R10836 T12662 T12661 arg1Of observed,not
R10837 T12662 T12663 arg1Of observed,in
R10838 T12662 T12667 arg1Of observed,in
R10839 T12663 T12666 arg1Of in,or
R10840 T12665 T12663 arg2Of individuals,in
R10841 T12665 T12664 arg1Of individuals,healthy
R10842 T12667 T12666 arg2Of in,or
R10843 T12668 T12667 arg2Of patients,in
R10844 T12668 T12669 arg1Of patients,with
R10845 T12671 T12669 arg2Of colitis,with
R10846 T12671 T12670 arg1Of colitis,ulcerative
R10847 T12671 T12672 arg1Of colitis,[
R10848 T12673 T12672 arg2Of 42,[
R10849 T12674 T12672 arg3Of ],[
R10850 T12679 T12677 arg2Of levels,increased
R10851 T12679 T12678 arg1Of levels,expression
R10852 T12679 T12680 arg1Of levels,of
R10853 T12679 T12687 arg1Of levels,were
R10854 T12679 T12689 arg2Of levels,detected
R10855 T12681 T12682 arg1Of ICAM-1,and
R10856 T12682 T12680 arg2Of and,of
R10857 T12682 T12684 arg1Of and,(
R10858 T12683 T12682 arg2Of LFA-3,and
R10859 T12685 T12684 arg2Of CD58,(
R10860 T12686 T12684 arg3Of ),(
R10861 T12689 T12675 arg1Of detected,Moreover
R10862 T12689 T12676 arg1Of detected,","
R10863 T12689 T12687 arg2Of detected,were
R10864 T12689 T12688 arg1Of detected,also
R10865 T12689 T12690 arg1Of detected,in
R10866 T12689 T12698 arg1Of detected,[
R10867 T12689 T12701 arg1Of detected,","
R10868 T12689 T12702 arg1Of detected,[
R10869 T12691 T12690 arg2Of monocytes,in
R10870 T12691 T12692 arg1Of monocytes,from
R10871 T12693 T12692 arg2Of patients,from
R10872 T12693 T12694 arg1Of patients,with
R10873 T12696 T12694 arg2Of 's,with
R10874 T12696 T12695 arg1Of 's,Crohn
R10875 T12696 T12697 arg1Of 's,disease
R10876 T12699 T12698 arg2Of 43,[
R10877 T12700 T12698 arg3Of ],[
R10878 T12703 T12702 arg2Of 44,[
R10879 T12704 T12702 arg3Of ],[
R10880 T12708 T12707 arg2Of CGN,degraded
R10881 T12708 T12710 arg1Of CGN,can
R10882 T12708 T12711 arg1Of CGN,activate
R10883 T12711 T12705 arg1Of activate,Thus
R10884 T12711 T12706 arg1Of activate,","
R10885 T12711 T12709 arg1Of activate,clearly
R10886 T12711 T12710 arg2Of activate,can
R10887 T12711 T12746 arg1Of activate,","
R10888 T12711 T12747 arg1Of activate,[
R10889 T12712 T12711 arg2Of monocytes,activate
R10890 T12712 T12713 modOf monocytes,to
R10891 T12712 T12736 arg1Of monocytes,","
R10892 T12714 T12713 arg1Of express,to
R10893 T12714 T12722 arg1Of express,","
R10894 T12717 T12714 arg2Of number,express
R10895 T12717 T12715 arg1Of number,an
R10896 T12717 T12716 arg2Of number,increased
R10897 T12717 T12718 arg1Of number,of
R10898 T12721 T12718 arg2Of molecules,of
R10899 T12721 T12719 arg1Of molecules,ICAM-1
R10900 T12721 T12720 arg1Of molecules,adhesion
R10901 T12724 T12714 arg3Of being,express
R10902 T12724 T12723 arg1Of being,therefore
R10903 T12725 T12724 arg2Of capable,being
R10904 T12725 T12726 arg1Of capable,of
R10905 T12725 T12731 arg1Of capable,of
R10906 T12727 T12726 arg2Of creating,of
R10907 T12729 T12727 arg2Of conditions,creating
R10908 T12729 T12728 arg1Of conditions,the
R10909 T12729 T12730 arg1Of conditions,characteristic
R10910 T12733 T12731 arg2Of 's,of
R10911 T12733 T12732 arg1Of 's,Crohn
R10912 T12733 T12734 arg1Of 's,disease
R10913 T12733 T12735 arg1Of 's,symptomatology
R10914 T12739 T12737 arg1Of accumulation,i.e.
R10915 T12739 T12738 arg1Of accumulation,PBM
R10916 T12739 T12740 arg1Of accumulation,and
R10917 T12740 T12736 arg2Of and,","
R10918 T12742 T12740 arg2Of formation,and
R10919 T12742 T12741 arg1Of formation,MGC
R10920 T12742 T12743 arg1Of formation,[
R10921 T12744 T12743 arg2Of 45,[
R10922 T12745 T12743 arg3Of ],[
R10923 T12748 T12747 arg2Of 46,[
R10924 T12749 T12747 arg3Of ],[
R10925 T12752 T12750 arg1Of pathway,The
R10926 T12752 T12751 arg1Of pathway,NF-κB
R10927 T12752 T12753 arg1Of pathway,regulates
R10928 T12754 T12753 arg2Of genes,regulates
R10929 T12754 T12755 arg1Of genes,responsible
R10930 T12755 T12756 arg1Of responsible,for
R10931 T12757 T12758 arg1Of ICAM-1,and
R10932 T12758 T12756 arg2Of and,for
R10933 T12760 T12758 arg2Of expression,and
R10934 T12760 T12759 arg1Of expression,TNF-α
R10935 T12762 T12761 arg1Of activation,NF-κB
R10936 T12762 T12763 arg1Of activation,is
R10937 T12762 T12764 arg2Of activation,associated
R10938 T12764 T12763 arg2Of associated,is
R10939 T12764 T12765 arg1Of associated,with
R10940 T12767 T12765 arg2Of degradation,with
R10941 T12767 T12766 arg1Of degradation,the
R10942 T12767 T12768 arg1Of degradation,of
R10943 T12772 T12768 arg2Of IκB,of
R10944 T12772 T12769 arg1Of IκB,the
R10945 T12772 T12770 arg1Of IκB,inhibitor
R10946 T12772 T12771 arg1Of IκB,protein
R10947 T12772 T12773 arg1Of IκB,[
R10948 T12774 T12773 arg2Of 47,[
R10949 T12775 T12773 arg3Of ],[
R10950 T12778 T12779 arg1Of dCGN,induced
R10951 T12779 T12776 arg1Of induced,Indeed
R10952 T12779 T12777 arg1Of induced,","
R10953 T12779 T12782 arg1Of induced,as
R10954 T12781 T12779 arg2Of activation,induced
R10955 T12781 T12780 arg1Of activation,NF-κB
R10956 T12783 T12782 arg2Of shown,as
R10957 T12785 T12783 arg1Of degradation,shown
R10958 T12785 T12784 arg2Of degradation,by
R10959 T12785 T12786 arg1Of degradation,of
R10960 T12785 T12799 arg1Of degradation,by
R10961 T12786 T12798 arg1Of of,and
R10962 T12787 T12788 arg1Of IκBα,","
R10963 T12788 T12786 arg2Of ",",of
R10964 T12789 T12788 arg2Of translocation,","
R10965 T12789 T12790 arg1Of translocation,of
R10966 T12789 T12795 arg1Of translocation,to
R10967 T12791 T12792 arg1Of p65,and
R10968 T12793 T12792 arg2Of p50,and
R10969 T12794 T12790 arg2Of sub-units,of
R10970 T12794 T12791 arg1Of sub-units,p65
R10971 T12794 T12793 arg1Of sub-units,p50
R10972 T12797 T12795 arg2Of nucleus,to
R10973 T12797 T12796 arg1Of nucleus,the
R10974 T12799 T12798 arg2Of by,and
R10975 T12800 T12799 arg2Of activation,by
R10976 T12800 T12801 arg1Of activation,of
R10977 T12806 T12801 arg2Of plasmid,of
R10978 T12806 T12802 arg1Of plasmid,an
R10979 T12806 T12803 arg1Of plasmid,NF-κB-responsive
R10980 T12806 T12804 arg1Of plasmid,luciferase
R10981 T12806 T12805 arg1Of plasmid,reporter
R10982 T12811 T12809 arg1Of activation,a
R10983 T12811 T12810 arg1Of activation,stronger
R10984 T12811 T12812 arg1Of activation,of
R10985 T12811 T12814 arg1Of activation,was
R10986 T12811 T12815 arg2Of activation,induced
R10987 T12813 T12812 arg2Of NF-κB,of
R10988 T12815 T12807 arg1Of induced,Again
R10989 T12815 T12808 arg1Of induced,","
R10990 T12815 T12814 arg2Of induced,was
R10991 T12815 T12821 arg1Of induced,compared
R10992 T12815 T12826 arg1Of induced,","
R10993 T12820 T12815 arg1Of dCGN,induced
R10994 T12820 T12816 arg2Of dCGN,by
R10995 T12820 T12817 arg1Of dCGN,the
R10996 T12820 T12818 arg1Of dCGN,40
R10997 T12820 T12819 arg1Of dCGN,kDa
R10998 T12822 T12821 arg2Of to,compared
R10999 T12825 T12822 arg2Of dCGN,to
R11000 T12825 T12823 arg1Of dCGN,10
R11001 T12825 T12824 arg1Of dCGN,kDa
R11002 T12827 T12815 arg3Of suggesting,induced
R11003 T12832 T12829 arg1Of CGN,the
R11004 T12832 T12830 arg1Of CGN,partially
R11005 T12832 T12831 arg2Of CGN,degraded
R11006 T12832 T12833 arg1Of CGN,is
R11007 T12832 T12836 arg1Of CGN,active
R11008 T12833 T12827 arg2Of is,suggesting
R11009 T12833 T12828 arg1Of is,that
R11010 T12835 T12834 arg1Of biologically,more
R11011 T12836 T12833 arg2Of active,is
R11012 T12836 T12835 arg1Of active,biologically
R11013 T12838 T12837 arg1Of data,Our
R11014 T12838 T12839 arg1Of data,are
R11015 T12838 T12840 arg1Of data,in
R11016 T12840 T12839 arg2Of in,are
R11017 T12841 T12840 arg2Of agreement,in
R11018 T12841 T12842 arg1Of agreement,with
R11019 T12845 T12842 arg2Of study,with
R11020 T12845 T12843 arg1Of study,a
R11021 T12845 T12844 arg1Of study,previous
R11022 T12845 T12846 arg1Of study,showing
R11023 T12849 T12848 arg1Of CGN,native
R11024 T12849 T12851 arg1Of CGN,induced
R11025 T12851 T12846 arg2Of induced,showing
R11026 T12851 T12847 arg1Of induced,that
R11027 T12851 T12850 arg1Of induced,also
R11028 T12851 T12855 arg1Of induced,in
R11029 T12852 T12851 arg2Of activation,induced
R11030 T12852 T12853 arg1Of activation,of
R11031 T12854 T12853 arg2Of NF-κB,of
R11032 T12859 T12855 arg2Of cells,in
R11033 T12859 T12856 arg1Of cells,human
R11034 T12859 T12857 arg1Of cells,colonic
R11035 T12859 T12858 arg1Of cells,epithelial
R11036 T12859 T12860 arg1Of cells,[
R11037 T12861 T12860 arg2Of 48,[
R11038 T12862 T12860 arg3Of ],[
R11039 T12864 T12863 arg1Of pathway,NF-κB
R11040 T12864 T12865 arg1Of pathway,is
R11041 T12864 T12867 arg2Of pathway,associated
R11042 T12867 T12865 arg2Of associated,is
R11043 T12867 T12866 arg1Of associated,often
R11044 T12867 T12868 modOf associated,to
R11045 T12867 T12876 arg1Of associated,","
R11046 T12869 T12868 arg1Of promote,to
R11047 T12871 T12870 arg1Of survival,cell
R11048 T12871 T12872 arg1Of survival,and
R11049 T12872 T12869 arg2Of and,promote
R11050 T12875 T12872 arg2Of growth,and
R11051 T12875 T12873 arg1Of growth,cancer
R11052 T12875 T12874 arg1Of growth,cell
R11053 T12878 T12879 arg1Of it,has
R11054 T12878 T12880 arg1Of it,been
R11055 T12878 T12882 arg2Of it,reported
R11056 T12878 T12884 arg1Of it,behave
R11057 T12878 T12890 arg1Of it,arresting
R11058 T12882 T12876 arg2Of reported,","
R11059 T12882 T12877 arg1Of reported,however
R11060 T12882 T12879 arg2Of reported,has
R11061 T12882 T12880 arg2Of reported,been
R11062 T12882 T12881 arg1Of reported,sometimes
R11063 T12884 T12882 arg3Of behave,reported
R11064 T12884 T12883 arg1Of behave,to
R11065 T12884 T12885 arg1Of behave,as
R11066 T12884 T12889 arg1Of behave,","
R11067 T12884 T12890 modOf behave,arresting
R11068 T12888 T12885 arg2Of suppressor,as
R11069 T12888 T12886 arg1Of suppressor,a
R11070 T12888 T12887 arg1Of suppressor,tumor
R11071 T12892 T12890 arg2Of proliferation,arresting
R11072 T12892 T12891 arg1Of proliferation,cell
R11073 T12892 T12893 arg1Of proliferation,[
R11074 T12894 T12893 arg2Of 49,[
R11075 T12895 T12893 arg3Of ],[
R11076 T12897 T12896 arg1Of relationship,Such
R11077 T12897 T12898 arg1Of relationship,between
R11078 T12897 T12905 arg1Of relationship,has
R11079 T12897 T12906 arg1Of relationship,been
R11080 T12897 T12907 arg2Of relationship,reported
R11081 T12900 T12899 arg1Of activation,NF-kB
R11082 T12900 T12901 arg1Of activation,and
R11083 T12901 T12898 arg2Of and,between
R11084 T12904 T12901 arg2Of regulation,and
R11085 T12904 T12902 arg1Of regulation,cell
R11086 T12904 T12903 arg1Of regulation,cycle
R11087 T12907 T12905 arg2Of reported,has
R11088 T12907 T12906 arg2Of reported,been
R11089 T12907 T12908 arg1Of reported,in
R11090 T12912 T12908 arg2Of cells,in
R11091 T12912 T12909 arg1Of cells,normal
R11092 T12912 T12910 arg1Of cells,human
R11093 T12912 T12911 arg1Of cells,epidermal
R11094 T12912 T12913 arg1Of cells,[
R11095 T12914 T12913 arg2Of 50,[
R11096 T12915 T12913 arg3Of ],[
R11097 T12918 T12919 arg1Of it,has
R11098 T12918 T12920 arg1Of it,been
R11099 T12918 T12921 arg2Of it,shown
R11100 T12921 T12916 arg1Of shown,Indeed
R11101 T12921 T12917 arg1Of shown,","
R11102 T12921 T12919 arg2Of shown,has
R11103 T12921 T12920 arg2Of shown,been
R11104 T12924 T12923 arg1Of activation,NF-κB
R11105 T12924 T12925 arg1Of activation,suppressed
R11106 T12925 T12921 arg3Of suppressed,shown
R11107 T12925 T12922 arg1Of suppressed,that
R11108 T12927 T12925 arg2Of expression,suppressed
R11109 T12927 T12926 arg1Of expression,cdk4
R11110 T12927 T12928 arg1Of expression,","
R11111 T12927 T12929 arg1Of expression,which
R11112 T12927 T12930 arg1Of expression,is
R11113 T12927 T12931 arg1Of expression,necessary
R11114 T12931 T12930 arg2Of necessary,is
R11115 T12931 T12932 arg1Of necessary,for
R11116 T12934 T12932 arg2Of transition,for
R11117 T12934 T12933 arg1Of transition,the
R11118 T12934 T12935 arg1Of transition,to
R11119 T12937 T12935 arg2Of phase,to
R11120 T12937 T12936 arg1Of phase,S
R11121 T12941 T12940 arg1Of activation,NF-κB
R11122 T12941 T12942 arg1Of activation,was
R11123 T12941 T12943 arg2Of activation,reported
R11124 T12941 T12945 arg1Of activation,induce
R11125 T12943 T12938 arg1Of reported,Finally
R11126 T12943 T12939 arg1Of reported,","
R11127 T12943 T12942 arg2Of reported,was
R11128 T12945 T12943 arg3Of induce,reported
R11129 T12945 T12944 arg1Of induce,to
R11130 T12947 T12945 arg2Of arrest,induce
R11131 T12947 T12946 arg1Of arrest,growth
R11132 T12947 T12948 arg1Of arrest,in
R11133 T12947 T12952 arg1Of arrest,by
R11134 T12951 T12948 arg2Of keratinocytes,in
R11135 T12951 T12949 arg1Of keratinocytes,normal
R11136 T12951 T12950 arg1Of keratinocytes,human
R11137 T12954 T12952 arg2Of mechanims,by
R11138 T12954 T12953 arg1Of mechanims,a
R11139 T12954 T12955 arg1Of mechanims,involving
R11140 T12955 T12960 arg1Of involving,[
R11141 T12959 T12955 arg2Of p21,involving
R11142 T12959 T12956 arg1Of p21,the
R11143 T12959 T12957 arg1Of p21,cdk
R11144 T12959 T12958 arg1Of p21,inhibitor
R11145 T12961 T12960 arg2Of 51,[
R11146 T12962 T12960 arg3Of ],[
R11147 T12964 T12963 arg1Of effects,The
R11148 T12964 T12965 arg1Of effects,of
R11149 T12964 T12967 arg1Of effects,on
R11150 T12964 T12972 arg1Of effects,remain
R11151 T12964 T12974 arg1Of effects,be
R11152 T12964 T12975 arg2Of effects,studied
R11153 T12966 T12965 arg2Of dCGN,of
R11154 T12968 T12969 arg1Of p21,and
R11155 T12970 T12969 arg2Of cdk4,and
R11156 T12971 T12967 arg2Of expression,on
R11157 T12971 T12968 arg1Of expression,p21
R11158 T12971 T12970 arg1Of expression,cdk4
R11159 T12975 T12972 arg2Of studied,remain
R11160 T12975 T12973 arg1Of studied,to
R11161 T12975 T12974 arg2Of studied,be
R11162 T12978 T12976 arg2Of studies,In
R11163 T12978 T12977 arg1Of studies,these
R11164 T12980 T12981 arg1Of we,have
R11165 T12980 T12982 arg1Of we,demonstrated
R11166 T12982 T12976 arg1Of demonstrated,In
R11167 T12982 T12979 arg1Of demonstrated,","
R11168 T12982 T12981 arg2Of demonstrated,have
R11169 T12985 T12982 arg2Of action,demonstrated
R11170 T12985 T12983 arg1Of action,a
R11171 T12985 T12984 arg1Of action,direct
R11172 T12985 T12986 arg1Of action,of
R11173 T12985 T12988 arg1Of action,on
R11174 T12987 T12986 arg2Of dCGN,of
R11175 T12989 T12988 arg2Of monocytes,on
R11176 T12990 T12991 arg2Of Monocytes,exposed
R11177 T12990 T12994 arg1Of Monocytes,acquired
R11178 T12991 T12992 arg1Of exposed,to
R11179 T12993 T12992 arg2Of dCGN,to
R11180 T12997 T12994 arg2Of phenotype,acquired
R11181 T12997 T12995 arg1Of phenotype,an
R11182 T12997 T12996 arg1Of phenotype,inflammatory
R11183 T12997 T12998 arg1Of phenotype,that
R11184 T12997 T12999 arg1Of phenotype,included
R11185 T13001 T13000 arg1Of expression,higher
R11186 T13001 T13002 arg1Of expression,of
R11187 T13001 T13007 arg1Of expression,and
R11188 T13006 T13002 arg2Of ICAM-1,of
R11189 T13006 T13003 arg1Of ICAM-1,the
R11190 T13006 T13004 arg1Of ICAM-1,adhesion
R11191 T13006 T13005 arg1Of ICAM-1,molecule
R11192 T13007 T12999 arg2Of and,included
R11193 T13007 T13010 arg1Of and,","
R11194 T13007 T13011 arg1Of and,via
R11195 T13009 T13007 arg2Of production,and
R11196 T13009 T13008 arg1Of production,TNF-α
R11197 T13014 T13011 arg2Of pathway,via
R11198 T13014 T13012 arg1Of pathway,the
R11199 T13014 T13013 arg1Of pathway,NF-κB
R11200 T13017 T13015 arg1Of expression,This
R11201 T13017 T13016 arg1Of expression,higher
R11202 T13017 T13018 arg1Of expression,of
R11203 T13017 T13020 arg1Of expression,resulted
R11204 T13019 T13018 arg2Of ICAM-1,of
R11205 T13020 T13021 arg1Of resulted,in
R11206 T13022 T13021 arg2Of formation,in
R11207 T13022 T13023 arg1Of formation,of
R11208 T13025 T13023 arg2Of aggregates,of
R11209 T13025 T13024 arg1Of aggregates,cell
R11210 T13025 T13026 arg1Of aggregates,similar
R11211 T13026 T13027 arg1Of similar,to
R11212 T13028 T13027 arg2Of those,to
R11213 T13028 T13029 arg2Of those,observed
R11214 T13029 T13030 arg1Of observed,in
R11215 T13031 T13030 arg2Of patients,in
R11216 T13031 T13032 arg1Of patients,with
R11217 T13034 T13032 arg2Of 's,with
R11218 T13034 T13033 arg1Of 's,Crohn
R11219 T13034 T13035 arg1Of 's,disease
R11220 T13036 T13037 arg1Of We,presume
R11221 T13041 T13039 arg1Of effects,the
R11222 T13041 T13040 arg1Of effects,differential
R11223 T13041 T13042 arg1Of effects,of
R11224 T13041 T13048 modOf effects,to
R11225 T13041 T13049 arg1Of effects,induce
R11226 T13041 T13054 arg1Of effects,are
R11227 T13041 T13056 arg2Of effects,linked
R11228 T13043 T13044 arg1Of 10,and
R11229 T13045 T13044 arg2Of 40,and
R11230 T13047 T13042 arg2Of dCGN,of
R11231 T13047 T13043 arg1Of dCGN,10
R11232 T13047 T13045 arg1Of dCGN,40
R11233 T13047 T13046 arg1Of dCGN,kDa
R11234 T13049 T13048 arg1Of induce,to
R11235 T13051 T13049 arg2Of effects,induce
R11236 T13051 T13050 arg1Of effects,these
R11237 T13051 T13052 arg1Of effects,on
R11238 T13053 T13052 arg2Of monocytes,on
R11239 T13056 T13037 arg2Of linked,presume
R11240 T13056 T13038 arg1Of linked,that
R11241 T13056 T13054 arg2Of linked,are
R11242 T13056 T13055 arg1Of linked,tightly
R11243 T13056 T13057 arg1Of linked,to
R11244 T13059 T13057 arg2Of capacity,to
R11245 T13059 T13058 arg1Of capacity,their
R11246 T13059 T13060 modOf capacity,to
R11247 T13061 T13060 arg1Of induce,to
R11248 T13062 T13061 arg2Of inflammation,induce
R11249 T13062 T13064 arg1Of inflammation,vivo
R11250 T13064 T13063 arg1Of vivo,in
R11251 T13068 T13067 arg1Of vivo,in
R11252 T13070 T13071 arg1Of macrophages,do
R11253 T13070 T13073 arg1Of macrophages,come
R11254 T13070 T13082 arg1Of macrophages,are
R11255 T13070 T13083 arg2Of macrophages,separated
R11256 T13073 T13071 arg2Of come,do
R11257 T13073 T13072 arg1Of come,not
R11258 T13073 T13074 arg1Of come,in
R11259 T13073 T13081 arg1Of come,and
R11260 T13076 T13074 arg2Of contact,in
R11261 T13076 T13075 arg1Of contact,direct
R11262 T13076 T13077 arg1Of contact,with
R11263 T13080 T13077 arg2Of lumen,with
R11264 T13080 T13078 arg1Of lumen,the
R11265 T13080 T13079 arg1Of lumen,intestinal
R11266 T13081 T13065 arg1Of and,However
R11267 T13081 T13066 arg1Of and,","
R11268 T13081 T13068 arg1Of and,vivo
R11269 T13081 T13069 arg1Of and,","
R11270 T13083 T13081 arg2Of separated,and
R11271 T13083 T13082 arg2Of separated,are
R11272 T13087 T13083 arg1Of barrier,separated
R11273 T13087 T13084 arg2Of barrier,by
R11274 T13087 T13085 arg1Of barrier,the
R11275 T13087 T13086 arg1Of barrier,epithelial
R11276 T13089 T13088 arg1Of way,The
R11277 T13089 T13090 arg2Of way,by
R11278 T13089 T13091 arg1Of way,which
R11279 T13089 T13107 arg1Of way,is
R11280 T13092 T13093 arg1Of dCGN,may
R11281 T13092 T13094 arg1Of dCGN,leave
R11282 T13092 T13099 arg1Of dCGN,cross
R11283 T13094 T13098 arg1Of leave,and
R11284 T13097 T13094 arg2Of lumen,leave
R11285 T13097 T13095 arg1Of lumen,the
R11286 T13097 T13096 arg1Of lumen,intestinal
R11287 T13098 T13090 arg1Of and,by
R11288 T13098 T13093 arg2Of and,may
R11289 T13098 T13103 modOf and,to
R11290 T13099 T13098 arg2Of cross,and
R11291 T13102 T13099 arg2Of barrier,cross
R11292 T13102 T13100 arg1Of barrier,the
R11293 T13102 T13101 arg1Of barrier,epithelial
R11294 T13104 T13103 arg1Of reach,to
R11295 T13106 T13104 arg2Of macrophages,reach
R11296 T13106 T13105 arg1Of macrophages,the
R11297 T13111 T13107 arg2Of question,is
R11298 T13111 T13108 arg1Of question,an
R11299 T13111 T13109 arg1Of question,intriguing
R11300 T13111 T13110 arg1Of question,open
R11301 T13114 T13112 arg1Of explanation,One
R11302 T13114 T13113 arg1Of explanation,possible
R11303 T13114 T13115 arg1Of explanation,resides
R11304 T13115 T13116 arg1Of resides,in
R11305 T13118 T13116 arg2Of potential,in
R11306 T13118 T13117 arg1Of potential,the
R11307 T13118 T13119 arg1Of potential,of
R11308 T13120 T13119 arg2Of dCGN,of
R11309 T13122 T13115 arg2Of “induce”,resides
R11310 T13122 T13121 arg1Of “induce”,to
R11311 T13122 T13128 arg1Of “induce”,at
R11312 T13122 T13134 arg1Of “induce”,[
R11313 T13123 T13124 arg1Of cellular,and
R11314 T13126 T13124 arg2Of injurious,and
R11315 T13126 T13125 arg1Of injurious,paracellular
R11316 T13127 T13122 arg2Of effects,“induce”
R11317 T13127 T13123 arg1Of effects,cellular
R11318 T13127 T13126 arg1Of effects,injurious
R11319 T13133 T13128 arg2Of monolayer,at
R11320 T13133 T13129 arg1Of monolayer,the
R11321 T13133 T13130 arg1Of monolayer,intestinal
R11322 T13133 T13131 arg1Of monolayer,epithelial
R11323 T13133 T13132 arg1Of monolayer,cell
R11324 T13135 T13134 arg2Of 48,[
R11325 T13136 T13134 arg3Of ],[
R11326 T13138 T13137 arg2Of conclusion,In
R11327 T13140 T13141 arg1Of dCGN,inhibited
R11328 T13140 T13148 arg1Of dCGN,accumulating
R11329 T13140 T13160 arg1Of dCGN,increased
R11330 T13140 T13164 arg1Of dCGN,stimulated
R11331 T13140 T13172 arg1Of dCGN,stimulated
R11332 T13141 T13146 arg1Of inhibited,vitro
R11333 T13141 T13147 arg1Of inhibited,","
R11334 T13141 T13148 modOf inhibited,accumulating
R11335 T13141 T13159 arg1Of inhibited,","
R11336 T13144 T13141 arg2Of proliferation,inhibited
R11337 T13144 T13142 arg1Of proliferation,THP-1
R11338 T13144 T13143 arg1Of proliferation,cell
R11339 T13146 T13145 arg1Of vitro,in
R11340 T13150 T13148 arg2Of cells,accumulating
R11341 T13150 T13149 arg1Of cells,the
R11342 T13150 T13151 arg1Of cells,in
R11343 T13154 T13151 arg2Of phase,in
R11344 T13154 T13152 arg1Of phase,the
R11345 T13154 T13153 arg1Of phase,G1
R11346 T13154 T13155 arg1Of phase,of
R11347 T13158 T13155 arg2Of cycle,of
R11348 T13158 T13156 arg1Of cycle,the
R11349 T13158 T13157 arg1Of cycle,cell
R11350 T13159 T13163 arg1Of ",",","
R11351 T13160 T13159 arg2Of increased,","
R11352 T13162 T13160 arg2Of expression,increased
R11353 T13162 T13161 arg1Of expression,ICAM-1
R11354 T13163 T13171 arg1Of ",",and
R11355 T13164 T13163 arg2Of stimulated,","
R11356 T13164 T13169 arg1Of stimulated,vitro
R11357 T13167 T13164 arg2Of aggregation,stimulated
R11358 T13167 T13165 arg1Of aggregation,ICAM-1-dependent
R11359 T13167 T13166 arg1Of aggregation,monocyte
R11360 T13169 T13168 arg1Of vitro,in
R11361 T13171 T13137 arg1Of and,In
R11362 T13171 T13139 arg1Of and,","
R11363 T13171 T13170 arg1Of and,","
R11364 T13172 T13171 arg2Of stimulated,and
R11365 T13174 T13175 arg1Of expression,and
R11366 T13175 T13172 arg2Of and,stimulated
R11367 T13175 T13173 arg1Of and,TNF-α
R11368 T13176 T13175 arg2Of secretion,and
R11369 T13178 T13177 arg1Of responses,These
R11370 T13178 T13179 arg1Of responses,were
R11371 T13178 T13181 arg1Of responses,pronounced
R11372 T13178 T13188 arg1Of responses,were
R11373 T13178 T13190 arg2Of responses,linked
R11374 T13179 T13182 arg1Of were,following
R11375 T13179 T13187 arg1Of were,and
R11376 T13181 T13179 arg2Of pronounced,were
R11377 T13181 T13180 arg1Of pronounced,more
R11378 T13185 T13182 arg2Of dCGN,following
R11379 T13185 T13183 arg1Of dCGN,40
R11380 T13185 T13184 arg1Of dCGN,kDa
R11381 T13187 T13186 arg1Of and,","
R11382 T13190 T13187 arg2Of linked,and
R11383 T13190 T13188 arg2Of linked,were
R11384 T13190 T13189 arg1Of linked,all
R11385 T13190 T13191 arg1Of linked,to
R11386 T13193 T13191 arg2Of activation,to
R11387 T13193 T13192 arg1Of activation,NF-κB
R11388 T13195 T13194 arg1Of results,These
R11389 T13195 T13196 arg1Of results,suggest
R11390 T13200 T13201 arg1Of CGN,is
R11391 T13200 T13203 arg2Of CGN,used
R11392 T13203 T13199 arg2Of used,although
R11393 T13203 T13201 arg2Of used,is
R11394 T13203 T13202 arg1Of used,widely
R11395 T13203 T13204 arg1Of used,as
R11396 T13206 T13204 arg2Of food,as
R11397 T13206 T13205 arg1Of food,a
R11398 T13206 T13207 arg1Of food,additive
R11399 T13211 T13209 arg1Of forms,its
R11400 T13211 T13210 arg1Of forms,degraded
R11401 T13211 T13212 arg1Of forms,have
R11402 T13212 T13196 arg2Of have,suggest
R11403 T13212 T13197 arg1Of have,that
R11404 T13212 T13198 arg1Of have,","
R11405 T13212 T13199 arg1Of have,although
R11406 T13212 T13208 arg1Of have,","
R11407 T13215 T13212 arg2Of effect,have
R11408 T13215 T13213 arg1Of effect,an
R11409 T13215 T13214 arg1Of effect,important
R11410 T13215 T13216 arg1Of effect,on
R11411 T13217 T13216 arg2Of monocytes,on
R11412 T13217 T13218 arg1Of monocytes,characteristic
R11413 T13218 T13219 arg1Of characteristic,of
R11414 T13222 T13219 arg2Of phenotype,of
R11415 T13222 T13220 arg1Of phenotype,an
R11416 T13222 T13221 arg1Of phenotype,inflammatory

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T13228 3978-3980 Anaphor denotes it
T13229 3932-3936 Antecedent denotes CD14
T13230 7772-7793 Anaphor denotes the adhesion molecule
T13231 7794-7800 Antecedent denotes ICAM-1
T13232 8053-8066 Anaphor denotes these effects
T13233 7851-7857 Antecedent denotes higher
T13223 3676-3679 Anaphor denotes one
T13224 3614-3617 Antecedent denotes TNF
T13225 3892-3907 Anaphor denotes these receptors
T13226 3781-3785 Antecedent denotes CD14
T13227 3790-3804 Antecedent denotes TLR4 receptors
R11419 T13225 T13227 boundBy these receptors,TLR4 receptors
R11420 T13228 T13229 boundBy it,CD14
R11421 T13230 T13231 boundBy the adhesion molecule,ICAM-1
R11422 T13232 T13233 boundBy these effects,higher
R11417 T13223 T13224 boundBy one,TNF
R11418 T13225 T13226 boundBy these receptors,CD14

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T13274 11-23 NNP denotes Inflammation
T13275 24-26 IN denotes of
T13276 27-30 DT denotes the
T13277 31-41 JJ denotes intestinal
T13278 42-47 NN denotes tract
T13279 48-50 VBZ denotes is
T13280 51-58 RB denotes usually
T13281 59-69 VBN denotes associated
T13282 70-74 IN denotes with
T13283 75-87 NN denotes infiltration
T13284 88-91 CC denotes and
T13285 92-102 NN denotes activation
T13286 103-105 IN denotes of
T13287 106-116 JJ denotes intestinal
T13288 117-128 NNS denotes macrophages
T13289 129-130 NNP denotes [
T13290 130-132 CD denotes 17
T13291 132-133 NNP denotes ]
T13292 133-134 . denotes .
T13293 135-140 DT denotes These
T13294 141-152 NNS denotes macrophages
T13295 153-156 VBP denotes are
T13296 157-161 JJ denotes able
T13297 162-164 TO denotes to
T13298 165-173 VB denotes initiate
T13299 174-180 JJ denotes immune
T13300 181-190 NNS denotes responses
T13301 191-194 CC denotes and
T13302 195-198 MD denotes can
T13303 199-201 VB denotes be
T13304 202-209 VBN denotes induced
T13305 210-212 TO denotes to
T13306 213-226 VB denotes differentiate
T13307 227-231 IN denotes into
T13308 232-237 NNS denotes cells
T13309 238-242 WDT denotes that
T13310 243-249 CC denotes either
T13311 250-260 VBP denotes exacerbate
T13312 261-263 CC denotes or
T13313 264-271 VBP denotes inhibit
T13314 272-275 DT denotes the
T13315 276-288 NN denotes inflammation
T13316 288-289 . denotes .
T13317 290-302 NNP denotes Accumulation
T13318 303-305 IN denotes of
T13319 306-315 JJ denotes different
T13320 316-321 NNS denotes types
T13321 322-324 IN denotes of
T13322 325-335 NNS denotes leukocytes
T13323 335-336 , denotes ,
T13324 337-346 VBG denotes including
T13325 347-368 NNS denotes monocytes/macrophages
T13326 368-369 , denotes ,
T13327 370-381 NNS denotes neutrophils
T13328 381-382 , denotes ,
T13329 383-386 CC denotes and
T13330 387-398 NNS denotes lymphocytes
T13331 399-401 IN denotes in
T13332 402-405 DT denotes the
T13333 406-416 JJ denotes intestinal
T13334 417-423 NN denotes mucosa
T13335 424-430 IN denotes during
T13336 431-443 NN denotes inflammation
T13337 443-444 , denotes ,
T13338 445-447 VBZ denotes is
T13339 448-456 RB denotes normally
T13340 457-465 VBN denotes followed
T13341 466-468 IN denotes by
T13342 469-478 NN denotes secretion
T13343 479-481 IN denotes of
T13344 482-498 JJ denotes pro-inflammatory
T13345 499-508 NNS denotes cytokines
T13346 509-510 NNP denotes [
T13347 510-512 CD denotes 33
T13348 512-513 NNP denotes ]
T13349 513-514 . denotes .
T13350 515-522 JJ denotes Several
T13351 523-530 NNS denotes stimuli
T13352 531-534 MD denotes can
T13353 535-541 VB denotes induce
T13354 542-547 DT denotes these
T13355 548-558 NNS denotes leukocytes
T13356 559-561 TO denotes to
T13357 562-569 VB denotes produce
T13358 570-573 CC denotes and
T13359 574-581 VB denotes secrete
T13360 582-591 NNS denotes cytokines
T13361 592-598 IN denotes during
T13362 599-611 NN denotes inflammation
T13363 611-612 . denotes .
T13364 613-616 CD denotes One
T13365 617-619 IN denotes of
T13366 620-623 DT denotes the
T13367 624-628 RBS denotes most
T13368 629-635 JJ denotes potent
T13369 636-639 CC denotes and
T13370 640-645 JJ denotes known
T13371 646-653 NNS denotes stimuli
T13372 654-657 IN denotes for
T13373 658-667 NN denotes leukocyte
T13374 668-678 NN denotes activation
T13375 679-681 VBZ denotes is
T13376 682-685 NNP denotes LPS
T13377 686-690 IN denotes from
T13378 691-704 JJ denotes Gram-negative
T13379 705-713 NNS denotes bacteria
T13380 714-715 NNP denotes [
T13381 715-717 CD denotes 34
T13382 717-718 NNP denotes ]
T13383 718-719 . denotes .
T13384 720-722 IN denotes In
T13385 723-731 NN denotes addition
T13386 731-732 , denotes ,
T13387 733-738 JJ denotes other
T13388 739-746 NNS denotes factors
T13389 747-750 VBP denotes are
T13390 751-755 RB denotes also
T13391 756-760 JJ denotes able
T13392 761-763 TO denotes to
T13393 764-773 VB denotes stimulate
T13394 774-782 JJ denotes cytokine
T13395 783-792 NN denotes secretion
T13396 793-797 IN denotes from
T13397 798-805 JJ denotes various
T13398 806-816 NNS denotes leukocytes
T13399 817-818 NNP denotes [
T13400 818-820 CD denotes 35
T13401 820-821 NNP denotes ]
T13402 821-822 , denotes ,
T13403 823-824 NNP denotes [
T13404 824-826 CD denotes 36
T13405 826-827 NNP denotes ]
T13406 827-828 . denotes .
T13407 829-832 CD denotes One
T13408 833-837 JJ denotes such
T13409 838-844 NN denotes factor
T13410 845-847 VBZ denotes is
T13411 848-851 NNP denotes CGN
T13412 851-852 , denotes ,
T13413 853-854 DT denotes a
T13414 855-859 JJ denotes high
T13415 860-869 JJ denotes molecular
T13416 870-876 NN denotes weight
T13417 877-886 VBN denotes sulphated
T13418 887-901 NN denotes polysaccharide
T13419 902-903 -LRB- denotes (
T13420 903-904 FW denotes >
T13421 904-907 CD denotes 200
T13422 908-911 NNP denotes kDa
T13423 911-912 -RRB- denotes )
T13424 913-920 VBN denotes derived
T13425 921-925 IN denotes from
T13426 926-929 JJ denotes red
T13427 930-935 NN denotes algae
T13428 936-937 -LRB- denotes (
T13429 937-949 NNP denotes Rhodophyceae
T13430 949-950 -RRB- denotes )
T13431 951-952 NNP denotes [
T13432 952-953 CD denotes 1
T13433 953-954 NNP denotes ]
T13434 954-955 , denotes ,
T13435 956-957 NNP denotes [
T13436 957-958 CD denotes 2
T13437 958-959 NNP denotes ]
T13438 959-960 . denotes .
T13439 961-967 JJ denotes Native
T13440 968-971 NNP denotes CGN
T13441 972-974 VBZ denotes is
T13442 975-981 RB denotes widely
T13443 982-986 VBN denotes used
T13444 987-989 IN denotes as
T13445 990-991 DT denotes a
T13446 992-996 NN denotes food
T13447 997-1005 JJ denotes additive
T13448 1006-1007 -LRB- denotes (
T13449 1007-1008 NNP denotes E
T13450 1009-1012 CD denotes 407
T13451 1012-1013 -RRB- denotes )
T13452 1014-1016 TO denotes to
T13453 1017-1024 VB denotes improve
T13454 1025-1032 NN denotes texture
T13455 1032-1033 . denotes .
T13456 1034-1036 PRP denotes It
T13457 1037-1039 VBZ denotes is
T13458 1040-1044 RB denotes also
T13459 1045-1049 VBN denotes used
T13460 1050-1052 IN denotes in
T13461 1053-1062 NNS denotes cosmetics
T13462 1063-1066 CC denotes and
T13463 1067-1082 NNS denotes pharmaceuticals
T13464 1082-1083 . denotes .
T13465 1084-1092 IN denotes Although
T13466 1093-1099 JJ denotes native
T13467 1100-1104 NN denotes form
T13468 1105-1108 NNP denotes CGN
T13469 1109-1110 -LRB- denotes (
T13470 1110-1113 CD denotes 200
T13471 1114-1117 CD denotes 800
T13472 1118-1121 NNP denotes kDa
T13473 1121-1122 -RRB- denotes )
T13474 1123-1126 VBZ denotes has
T13475 1127-1131 VBN denotes been
T13476 1132-1140 VBN denotes declared
T13477 1141-1149 JJ denotes harmless
T13478 1150-1152 TO denotes to
T13479 1153-1159 NNS denotes humans
T13480 1160-1161 VBP denotes [
T13481 1161-1162 CD denotes 8
T13482 1162-1163 NNP denotes ]
T13483 1163-1164 , denotes ,
T13484 1165-1168 PRP$ denotes its
T13485 1169-1177 JJ denotes degraded
T13486 1178-1183 NNS denotes forms
T13487 1184-1185 -LRB- denotes (
T13488 1185-1186 CD denotes <
T13489 1186-1188 CD denotes 50
T13490 1189-1192 NN denotes kDa
T13491 1192-1193 -RRB- denotes )
T13492 1193-1194 , denotes ,
T13493 1195-1199 RB denotes also
T13494 1200-1205 VBN denotes known
T13495 1206-1208 IN denotes as
T13496 1209-1219 NN denotes poligeenan
T13497 1219-1220 , denotes ,
T13498 1221-1224 VBP denotes are
T13499 1225-1231 RB denotes widely
T13500 1232-1236 VBN denotes used
T13501 1237-1239 TO denotes to
T13502 1240-1246 VB denotes induce
T13503 1247-1254 NN denotes colitis
T13504 1255-1257 IN denotes in
T13505 1258-1265 NNS denotes rodents
T13506 1266-1267 VBP denotes [
T13507 1267-1268 CD denotes 3
T13508 1268-1269 JJ denotes ]
T13509 1270-1271 NN denotes [
T13510 1271-1272 CD denotes 5
T13511 1272-1273 NNP denotes ]
T13512 1273-1274 . denotes .
T13513 1275-1280 DT denotes These
T13514 1281-1289 JJ denotes degraded
T13515 1290-1293 NNP denotes CGN
T13516 1294-1297 MD denotes may
T13517 1298-1302 RB denotes also
T13518 1303-1307 VB denotes have
T13519 1308-1309 DT denotes a
T13520 1310-1318 JJ denotes possible
T13521 1319-1331 JJ denotes carcinogenic
T13522 1332-1338 NN denotes effect
T13523 1339-1340 NN denotes [
T13524 1340-1341 CD denotes 4
T13525 1341-1342 NNP denotes ]
T13526 1342-1343 , denotes ,
T13527 1344-1345 NNP denotes [
T13528 1345-1346 CD denotes 6
T13529 1346-1347 NNP denotes ]
T13530 1348-1349 NN denotes [
T13531 1349-1350 CD denotes 8
T13532 1350-1351 NNP denotes ]
T13533 1351-1352 : denotes ;
T13534 1353-1360 RB denotes however
T13535 1361-1365 DT denotes this
T13536 1366-1368 VBZ denotes is
T13537 1369-1374 RB denotes still
T13538 1375-1388 JJ denotes controversial
T13539 1388-1389 . denotes .
T13540 1390-1398 IN denotes Although
T13541 1399-1403 NN denotes acid
T13542 1404-1413 NN denotes treatment
T13543 1414-1416 IN denotes at
T13544 1417-1421 JJ denotes high
T13545 1422-1433 NN denotes temperature
T13546 1434-1435 -LRB- denotes (
T13547 1435-1437 CD denotes 80
T13548 1437-1438 CD denotes °
T13549 1438-1439 NNP denotes C
T13550 1439-1440 -RRB- denotes )
T13551 1441-1443 VBZ denotes is
T13552 1444-1452 VBN denotes required
T13553 1453-1456 IN denotes for
T13554 1457-1460 NNP denotes CGN
T13555 1461-1471 NN denotes hydrolysis
T13556 1472-1474 IN denotes in
T13557 1475-1480 NN denotes vitro
T13558 1481-1483 TO denotes to
T13559 1484-1489 JJR denotes lower
T13560 1490-1499 JJ denotes molecular
T13561 1500-1506 NN denotes weight
T13562 1507-1511 NNP denotes dCGN
T13563 1511-1512 , denotes ,
T13564 1513-1515 PRP denotes it
T13565 1516-1518 VBZ denotes is
T13566 1519-1527 JJ denotes probable
T13567 1528-1532 IN denotes that
T13568 1533-1537 DT denotes some
T13569 1538-1542 NNP denotes dCGN
T13570 1543-1546 VBP denotes are
T13571 1547-1555 VBN denotes produced
T13572 1556-1558 IN denotes by
T13573 1559-1563 NN denotes acid
T13574 1564-1574 NN denotes hydrolysis
T13575 1575-1581 IN denotes during
T13576 1582-1589 JJ denotes gastric
T13577 1590-1599 NN denotes digestion
T13578 1600-1601 NN denotes [
T13579 1601-1602 CD denotes 9
T13580 1602-1603 NNP denotes ]
T13581 1603-1604 , denotes ,
T13582 1605-1606 NNP denotes [
T13583 1606-1608 CD denotes 10
T13584 1608-1609 NNP denotes ]
T13585 1610-1612 CC denotes or
T13586 1613-1624 NN denotes interaction
T13587 1625-1629 IN denotes with
T13588 1630-1640 JJ denotes intestinal
T13589 1641-1649 NNS denotes bacteria
T13590 1650-1651 NNP denotes [
T13591 1651-1653 CD denotes 11
T13592 1653-1654 NNP denotes ]
T13593 1654-1655 , denotes ,
T13594 1656-1657 NNP denotes [
T13595 1657-1659 CD denotes 12
T13596 1659-1660 NNP denotes ]
T13597 1660-1661 . denotes .
T13598 1662-1666 RB denotes Thus
T13599 1666-1667 , denotes ,
T13600 1668-1681 VBG denotes understanding
T13601 1682-1685 DT denotes the
T13602 1686-1696 NNS denotes mechanisms
T13603 1697-1699 IN denotes of
T13604 1700-1712 JJ denotes dCGN-induced
T13605 1713-1718 NN denotes bowel
T13606 1719-1731 NN denotes inflammation
T13607 1732-1734 VBZ denotes is
T13608 1735-1737 IN denotes of
T13609 1738-1743 JJ denotes great
T13610 1744-1754 NN denotes importance
T13611 1754-1755 . denotes .
T13612 1756-1758 IN denotes In
T13613 1759-1763 DT denotes this
T13614 1764-1770 NN denotes report
T13615 1770-1771 , denotes ,
T13616 1772-1774 PRP denotes we
T13617 1775-1779 VBP denotes have
T13618 1780-1788 VBN denotes analyzed
T13619 1789-1792 DT denotes the
T13620 1793-1797 NN denotes role
T13621 1798-1800 IN denotes of
T13622 1801-1806 JJ denotes human
T13623 1807-1816 NNS denotes monocytes
T13624 1817-1818 -LRB- denotes (
T13625 1818-1821 NNP denotes PBM
T13626 1822-1825 CC denotes and
T13627 1826-1831 NNP denotes THP-1
T13628 1831-1832 -RRB- denotes )
T13629 1833-1835 IN denotes in
T13630 1836-1848 JJ denotes dCGN-induced
T13631 1849-1861 NN denotes inflammation
T13632 1861-1862 . denotes .
T13633 1863-1874 JJ denotes Preliminary
T13634 1875-1877 IN denotes in
T13635 1878-1882 NN denotes vivo
T13636 1883-1890 NNS denotes studies
T13637 1891-1893 IN denotes in
T13638 1894-1898 NNS denotes rats
T13639 1899-1906 VBN denotes treated
T13640 1907-1911 IN denotes with
T13641 1912-1916 NNP denotes dCGN
T13642 1917-1925 VBD denotes revealed
T13643 1926-1937 JJ denotes significant
T13644 1938-1948 VBG denotes shortening
T13645 1949-1951 IN denotes of
T13646 1952-1955 DT denotes the
T13647 1956-1961 JJ denotes large
T13648 1962-1971 JJ denotes intestine
T13649 1972-1982 VBN denotes associated
T13650 1983-1987 IN denotes with
T13651 1988-1990 DT denotes an
T13652 1991-2003 JJ denotes inflammatory
T13653 2004-2009 NN denotes state
T13654 2009-2010 , denotes ,
T13655 2011-2015 FW denotes i.e.
T13656 2016-2022 JJ denotes strong
T13657 2023-2035 NN denotes infiltration
T13658 2036-2038 IN denotes of
T13659 2039-2050 NNS denotes macrophages
T13660 2051-2053 TO denotes to
T13661 2054-2057 DT denotes the
T13662 2058-2068 JJ denotes intestinal
T13663 2069-2075 NN denotes mucosa
T13664 2076-2083 JJ denotes similar
T13665 2084-2086 TO denotes to
T13666 2087-2098 JJ denotes DSS-induced
T13667 2099-2111 NN denotes inflammation
T13668 2112-2113 NNP denotes [
T13669 2113-2115 CD denotes 20
T13670 2115-2116 NNP denotes ]
T13671 2116-2117 . denotes .
T13672 2118-2123 VBG denotes Using
T13673 2124-2127 CD denotes two
T13674 2128-2137 NNS denotes fractions
T13675 2138-2140 IN denotes of
T13676 2141-2145 NNP denotes dCGN
T13677 2146-2147 -LRB- denotes (
T13678 2147-2149 CD denotes 10
T13679 2150-2153 CC denotes and
T13680 2154-2156 CD denotes 40
T13681 2157-2160 NN denotes kDa
T13682 2160-2161 -RRB- denotes )
T13683 2161-2162 , denotes ,
T13684 2163-2165 PRP denotes we
T13685 2166-2174 VBD denotes observed
T13686 2175-2176 DT denotes a
T13687 2177-2183 JJ denotes strong
T13688 2184-2195 NN denotes correlation
T13689 2196-2203 IN denotes between
T13690 2204-2207 DT denotes the
T13691 2208-2216 NN denotes severity
T13692 2217-2219 IN denotes of
T13693 2220-2223 DT denotes the
T13694 2224-2236 NN denotes inflammation
T13695 2237-2240 CC denotes and
T13696 2241-2244 DT denotes the
T13697 2245-2249 NNP denotes dCGN
T13698 2250-2259 JJ denotes molecular
T13699 2260-2264 NN denotes size
T13700 2264-2265 , denotes ,
T13701 2266-2270 RB denotes thus
T13702 2271-2281 VBG denotes confirming
T13703 2282-2285 DT denotes the
T13704 2286-2290 NN denotes size
T13705 2291-2298 VBN denotes related
T13706 2299-2311 NN denotes inflammation
T13707 2312-2314 IN denotes in
T13708 2315-2319 NN denotes vivo
T13709 2319-2320 . denotes .
T13710 2321-2325 DT denotes This
T13711 2326-2336 NN denotes macrophage
T13712 2337-2349 NN denotes accumulation
T13713 2350-2353 VBD denotes was
T13714 2354-2357 RB denotes not
T13715 2358-2361 JJ denotes due
T13716 2362-2364 TO denotes to
T13717 2365-2369 NN denotes cell
T13718 2370-2383 NN denotes proliferation
T13719 2384-2391 IN denotes because
T13720 2392-2396 NNP denotes dCGN
T13721 2397-2406 VBD denotes inhibited
T13722 2407-2412 CD denotes THP-1
T13723 2413-2422 NNS denotes monocytes
T13724 2423-2436 NN denotes proliferation
T13725 2437-2439 IN denotes in
T13726 2440-2445 NN denotes vitro
T13727 2445-2446 . denotes .
T13728 2447-2452 DT denotes These
T13729 2453-2460 NNS denotes results
T13730 2461-2464 VBP denotes are
T13731 2465-2472 JJ denotes similar
T13732 2473-2475 TO denotes to
T13733 2476-2481 DT denotes those
T13734 2482-2490 VBN denotes obtained
T13735 2491-2495 IN denotes with
T13736 2496-2501 JJ denotes human
T13737 2502-2509 JJ denotes colonic
T13738 2510-2520 JJ denotes epithelial
T13739 2521-2526 NNS denotes cells
T13740 2527-2528 -LRB- denotes (
T13741 2528-2534 CD denotes NCM460
T13742 2535-2539 NN denotes cell
T13743 2540-2544 NN denotes line
T13744 2544-2545 -RRB- denotes )
T13745 2546-2553 VBN denotes exposed
T13746 2554-2556 TO denotes to
T13747 2557-2563 JJ denotes native
T13748 2564-2567 NNP denotes CGN
T13749 2568-2571 IN denotes for
T13750 2572-2573 CD denotes 1
T13751 2574-2575 CD denotes 8
T13752 2576-2580 NNS denotes days
T13753 2581-2582 NNP denotes [
T13754 2582-2584 CD denotes 37
T13755 2584-2585 NNP denotes ]
T13756 2585-2586 . denotes .
T13757 2587-2591 RB denotes Thus
T13758 2591-2592 , denotes ,
T13759 2593-2595 PRP denotes it
T13760 2596-2601 VBZ denotes seems
T13761 2602-2606 IN denotes that
T13762 2607-2611 NNP denotes dCGN
T13763 2612-2619 VB denotes promote
T13764 2620-2630 NN denotes macrophage
T13765 2631-2643 NN denotes infiltration
T13766 2644-2646 IN denotes by
T13767 2647-2657 VBG denotes recruiting
T13768 2658-2661 JJ denotes new
T13769 2662-2667 NNS denotes cells
T13770 2668-2670 TO denotes to
T13771 2671-2674 DT denotes the
T13772 2675-2683 JJ denotes inflamed
T13773 2684-2694 JJ denotes intestinal
T13774 2695-2701 NN denotes mucosa
T13775 2702-2705 CC denotes and
T13776 2706-2709 RB denotes not
T13777 2710-2712 IN denotes by
T13778 2713-2721 VBG denotes inducing
T13779 2722-2726 NN denotes cell
T13780 2727-2740 NN denotes proliferation
T13781 2740-2741 . denotes .
T13782 2742-2744 IN denotes In
T13783 2745-2753 NN denotes addition
T13784 2753-2754 , denotes ,
T13785 2755-2759 RB denotes very
T13786 2760-2763 JJ denotes few
T13787 2764-2781 NN denotes polymorphonuclear
T13788 2782-2787 NNS denotes cells
T13789 2788-2792 VBD denotes were
T13790 2793-2801 VBN denotes detected
T13791 2802-2804 IN denotes in
T13792 2805-2808 DT denotes the
T13793 2809-2815 NN denotes mucosa
T13794 2816-2818 IN denotes at
T13795 2819-2822 DT denotes the
T13796 2823-2827 NN denotes time
T13797 2828-2833 NN denotes point
T13798 2834-2842 VBD denotes analyzed
T13799 2843-2845 IN denotes as
T13800 2846-2858 VBN denotes demonstrated
T13801 2859-2861 IN denotes by
T13802 2862-2863 DT denotes a
T13803 2864-2868 RB denotes very
T13804 2869-2872 JJ denotes low
T13805 2873-2878 NN denotes level
T13806 2879-2881 IN denotes of
T13807 2882-2885 NNP denotes MPO
T13808 2886-2888 IN denotes in
T13809 2889-2892 DT denotes the
T13810 2893-2903 JJ denotes intestinal
T13811 2904-2910 NN denotes tissue
T13812 2910-2911 . denotes .
T13813 2912-2917 DT denotes These
T13814 2918-2925 NNS denotes results
T13815 2926-2933 VBP denotes suggest
T13816 2934-2938 IN denotes that
T13817 2939-2948 NNS denotes monocytes
T13818 2949-2954 MD denotes might
T13819 2955-2962 VB denotes produce
T13820 2963-2972 NNS denotes cytokines
T13821 2973-2983 VBN denotes associated
T13822 2984-2988 IN denotes with
T13823 2989-2999 NN denotes activation
T13824 3000-3004 IN denotes into
T13825 3005-3016 NNS denotes macrophages
T13826 3017-3019 IN denotes in
T13827 3020-3028 NN denotes response
T13828 3029-3031 TO denotes to
T13829 3032-3036 NNP denotes dCGN
T13830 3036-3037 . denotes .
T13831 3038-3042 RB denotes Thus
T13832 3042-3043 , denotes ,
T13833 3044-3046 PRP denotes we
T13834 3047-3055 VBD denotes analyzed
T13835 3056-3059 DT denotes the
T13836 3060-3070 NN denotes production
T13837 3071-3073 IN denotes of
T13838 3074-3077 NNP denotes TNF
T13839 3078-3080 IN denotes by
T13840 3081-3085 DT denotes both
T13841 3086-3089 NNP denotes PBM
T13842 3090-3093 CC denotes and
T13843 3094-3099 NNP denotes THP-1
T13844 3100-3105 NNS denotes cells
T13845 3106-3108 IN denotes in
T13846 3109-3117 NN denotes response
T13847 3118-3120 TO denotes to
T13848 3121-3125 NNP denotes dCGN
T13849 3125-3126 . denotes .
T13850 3127-3135 JJ denotes Degraded
T13851 3136-3139 NNP denotes CGN
T13852 3140-3147 VBD denotes induced
T13853 3148-3149 DT denotes a
T13854 3150-3156 JJ denotes robust
T13855 3157-3167 NN denotes production
T13856 3168-3170 IN denotes of
T13857 3171-3174 NNP denotes TNF
T13858 3175-3177 IN denotes by
T13859 3178-3187 NNS denotes monocytes
T13860 3187-3188 . denotes .
T13861 3189-3192 DT denotes The
T13862 3193-3195 CD denotes 40
T13863 3196-3199 NNP denotes kDa
T13864 3200-3204 NN denotes form
T13865 3205-3207 IN denotes of
T13866 3208-3212 NNP denotes dCGN
T13867 3213-3216 VBD denotes was
T13868 3217-3221 RBR denotes more
T13869 3222-3228 JJ denotes potent
T13870 3229-3232 IN denotes for
T13871 3233-3241 NN denotes monocyte
T13872 3242-3253 NN denotes stimulation
T13873 3254-3258 IN denotes than
T13874 3259-3262 DT denotes the
T13875 3263-3265 CD denotes 10
T13876 3266-3269 NN denotes kDa
T13877 3270-3272 CC denotes or
T13878 3273-3276 DT denotes the
T13879 3277-3283 JJ denotes native
T13880 3284-3288 NNS denotes ones
T13881 3288-3289 . denotes .
T13882 3290-3302 RB denotes Surprisingly
T13883 3302-3303 , denotes ,
T13884 3304-3312 NN denotes monocyte
T13885 3313-3323 NN denotes activation
T13886 3324-3326 IN denotes by
T13887 3327-3331 NNP denotes dCGN
T13888 3332-3334 TO denotes to
T13889 3335-3342 VB denotes produce
T13890 3343-3346 NNP denotes TNF
T13891 3347-3350 VBD denotes was
T13892 3351-3355 JJ denotes much
T13893 3356-3364 JJR denotes stronger
T13894 3365-3369 IN denotes than
T13895 3370-3373 DT denotes the
T13896 3374-3384 NN denotes activation
T13897 3385-3392 VBN denotes induced
T13898 3393-3395 IN denotes by
T13899 3396-3399 NNP denotes LPS
T13900 3399-3400 , denotes ,
T13901 3401-3403 DT denotes an
T13902 3404-3416 JJ denotes inflammatory
T13903 3417-3423 NN denotes factor
T13904 3424-3434 VBN denotes considered
T13905 3435-3437 TO denotes to
T13906 3438-3440 VB denotes be
T13907 3441-3446 IN denotes among
T13908 3447-3450 DT denotes the
T13909 3451-3455 RBS denotes most
T13910 3456-3462 JJ denotes potent
T13911 3463-3470 NNS denotes stimuli
T13912 3471-3474 IN denotes for
T13913 3475-3484 NN denotes leukocyte
T13914 3485-3495 NN denotes activation
T13915 3495-3496 . denotes .
T13916 3497-3502 DT denotes These
T13917 3503-3510 NNS denotes results
T13918 3511-3520 VBP denotes underline
T13919 3521-3524 DT denotes the
T13920 3525-3529 NN denotes fact
T13921 3530-3534 IN denotes that
T13922 3535-3544 RB denotes partially
T13923 3545-3553 JJ denotes degraded
T13924 3554-3559 NNS denotes forms
T13925 3560-3562 IN denotes of
T13926 3563-3566 NNP denotes CGN
T13927 3567-3571 VBP denotes have
T13928 3572-3581 JJ denotes important
T13929 3582-3590 JJ denotes cellular
T13930 3591-3598 NNS denotes effects
T13931 3598-3599 . denotes .
T13932 3600-3603 DT denotes The
T13933 3604-3610 NN denotes amount
T13934 3611-3613 IN denotes of
T13935 3614-3617 NNP denotes TNF
T13936 3618-3626 VBN denotes secreted
T13937 3627-3629 IN denotes by
T13938 3630-3633 NNP denotes PBM
T13939 3634-3641 VBD denotes induced
T13940 3642-3646 IN denotes with
T13941 3647-3650 NNP denotes LPS
T13942 3651-3654 VBD denotes was
T13943 3655-3659 RB denotes much
T13944 3660-3666 JJR denotes larger
T13945 3667-3671 IN denotes than
T13946 3672-3675 DT denotes the
T13947 3676-3679 CD denotes one
T13948 3680-3688 VBN denotes secreted
T13949 3689-3691 IN denotes by
T13950 3692-3697 CD denotes THP-1
T13951 3698-3707 NNS denotes monocytes
T13952 3707-3708 . denotes .
T13953 3709-3714 IN denotes Since
T13954 3715-3723 NN denotes monocyte
T13955 3724-3734 NN denotes activation
T13956 3735-3737 IN denotes by
T13957 3738-3741 NNP denotes LPS
T13958 3742-3744 VBZ denotes is
T13959 3745-3755 VBN denotes associated
T13960 3756-3760 IN denotes with
T13961 3761-3764 DT denotes the
T13962 3765-3773 NN denotes presence
T13963 3774-3776 IN denotes of
T13964 3777-3780 DT denotes the
T13965 3781-3785 NNP denotes CD14
T13966 3786-3789 CC denotes and
T13967 3790-3794 NNP denotes TLR4
T13968 3795-3804 NNS denotes receptors
T13969 3805-3806 NNP denotes [
T13970 3806-3808 CD denotes 38
T13971 3808-3809 NNP denotes ]
T13972 3810-3811 NNP denotes [
T13973 3811-3813 CD denotes 40
T13974 3813-3814 NNP denotes ]
T13975 3814-3815 , denotes ,
T13976 3816-3819 DT denotes the
T13977 3820-3829 JJ denotes different
T13978 3830-3838 NN denotes response
T13979 3839-3847 VBD denotes observed
T13980 3848-3853 MD denotes could
T13981 3854-3856 VB denotes be
T13982 3857-3860 JJ denotes due
T13983 3861-3863 TO denotes to
T13984 3864-3867 DT denotes the
T13985 3868-3877 JJ denotes different
T13986 3878-3888 NN denotes expression
T13987 3889-3891 IN denotes of
T13988 3892-3897 DT denotes these
T13989 3898-3907 NNS denotes receptors
T13990 3908-3910 IN denotes in
T13991 3911-3914 NNP denotes PBM
T13992 3915-3918 CC denotes and
T13993 3919-3924 NNP denotes THP-1
T13994 3925-3930 NNS denotes cells
T13995 3930-3931 . denotes .
T13996 3932-3936 CD denotes CD14
T13997 3937-3939 VBZ denotes is
T13998 3940-3943 RB denotes not
T13999 3944-3953 VBN denotes expressed
T14000 3954-3956 IN denotes by
T14001 3957-3962 CD denotes THP-1
T14002 3963-3972 NNS denotes monocytes
T14003 3972-3973 , denotes ,
T14004 3974-3977 CC denotes but
T14005 3978-3980 PRP denotes it
T14006 3981-3983 VBZ denotes is
T14007 3984-3993 VBN denotes expressed
T14008 3994-3996 IN denotes by
T14009 3997-4000 NNP denotes PBM
T14010 4000-4001 . denotes .
T14011 4002-4006 DT denotes This
T14012 4007-4011 NN denotes fact
T14013 4012-4017 MD denotes could
T14014 4018-4025 VB denotes explain
T14015 4026-4029 WRB denotes why
T14016 4030-4035 JJ denotes THP-1
T14017 4036-4041 NNS denotes cells
T14018 4042-4050 VBD denotes produced
T14019 4051-4052 DT denotes a
T14020 4053-4057 RB denotes much
T14021 4058-4065 JJR denotes smaller
T14022 4066-4074 NN denotes response
T14023 4075-4077 TO denotes to
T14024 4078-4081 NNP denotes LPS
T14025 4082-4086 IN denotes than
T14026 4087-4090 NNP denotes PBM
T14027 4091-4094 CC denotes and
T14028 4095-4099 RB denotes also
T14029 4100-4103 DT denotes the
T14030 4104-4114 NN denotes difference
T14031 4115-4117 IN denotes of
T14032 4118-4126 NNS denotes kinetics
T14033 4127-4129 IN denotes in
T14034 4130-4133 DT denotes the
T14035 4134-4137 NNP denotes LPS
T14036 4138-4145 VBD denotes induced
T14037 4146-4149 NNP denotes TNF
T14038 4150-4159 NN denotes secretion
T14039 4159-4160 . denotes .
T14040 4161-4164 DT denotes The
T14041 4165-4169 NN denotes peak
T14042 4170-4172 IN denotes of
T14043 4173-4176 NNP denotes TNF
T14044 4177-4185 NN denotes response
T14045 4186-4189 VBD denotes was
T14046 4190-4198 VBN denotes observed
T14047 4199-4204 IN denotes after
T14048 4205-4206 CD denotes 8
T14049 4207-4208 NN denotes h
T14050 4209-4220 NN denotes stimulation
T14051 4221-4229 VBN denotes followed
T14052 4230-4232 IN denotes by
T14053 4233-4234 DT denotes a
T14054 4235-4240 JJ denotes rapid
T14055 4241-4249 NN denotes decrease
T14056 4250-4252 TO denotes to
T14057 4253-4261 NN denotes baseline
T14058 4262-4264 IN denotes at
T14059 4265-4267 CD denotes 10
T14060 4268-4269 NN denotes h
T14061 4269-4270 , denotes ,
T14062 4271-4278 IN denotes whereas
T14063 4279-4281 IN denotes on
T14064 4282-4287 CD denotes THP-1
T14065 4288-4293 NNS denotes cells
T14066 4294-4297 DT denotes the
T14067 4298-4302 NN denotes peak
T14068 4303-4306 VBD denotes was
T14069 4307-4310 RB denotes not
T14070 4311-4318 VBN denotes reached
T14071 4319-4324 IN denotes until
T14072 4325-4330 IN denotes after
T14073 4331-4333 CD denotes 56
T14074 4334-4336 NN denotes h.
T14075 4337-4345 RB denotes Moreover
T14076 4345-4346 , denotes ,
T14077 4347-4350 DT denotes the
T14078 4351-4357 NN denotes amount
T14079 4358-4360 IN denotes of
T14080 4361-4364 NNP denotes TNF
T14081 4365-4373 VBN denotes secreted
T14082 4374-4376 IN denotes by
T14083 4377-4386 NNS denotes monocytes
T14084 4387-4394 VBN denotes induced
T14085 4395-4399 IN denotes with
T14086 4400-4404 NNP denotes dCGN
T14087 4405-4408 VBD denotes was
T14088 4409-4413 RB denotes much
T14089 4414-4420 JJR denotes larger
T14090 4421-4425 IN denotes than
T14091 4426-4429 DT denotes the
T14092 4430-4433 CD denotes one
T14093 4434-4441 VBN denotes induced
T14094 4442-4444 IN denotes by
T14095 4445-4448 NNP denotes LPS
T14096 4448-4449 . denotes .
T14097 4450-4452 IN denotes On
T14098 4453-4456 DT denotes the
T14099 4457-4462 JJ denotes other
T14100 4463-4467 NN denotes hand
T14101 4467-4468 , denotes ,
T14102 4469-4472 NNP denotes LPS
T14103 4473-4476 CC denotes and
T14104 4477-4481 NNP denotes dCGN
T14105 4482-4491 VBD denotes displayed
T14106 4492-4493 DT denotes a
T14107 4494-4498 RB denotes very
T14108 4499-4508 JJ denotes different
T14109 4509-4512 NNP denotes TNF
T14110 4513-4522 NN denotes secretion
T14111 4523-4528 NN denotes curve
T14112 4529-4531 IN denotes in
T14113 4532-4537 CD denotes THP-1
T14114 4538-4543 NNS denotes cells
T14115 4543-4544 . denotes .
T14116 4545-4550 DT denotes These
T14117 4551-4562 NNS denotes differences
T14118 4563-4570 VBP denotes suggest
T14119 4571-4575 IN denotes that
T14120 4576-4580 NNP denotes dCGN
T14121 4581-4584 CC denotes and
T14122 4585-4588 NNP denotes LPS
T14123 4589-4594 MD denotes could
T14124 4595-4598 VB denotes use
T14125 4599-4608 JJ denotes different
T14126 4609-4619 NN denotes activation
T14127 4620-4630 NNS denotes mechanisms
T14128 4630-4631 . denotes .
T14129 4632-4634 PRP denotes It
T14130 4635-4637 VBZ denotes is
T14131 4638-4648 JJ denotes noteworthy
T14132 4649-4653 IN denotes that
T14133 4654-4666 VBG denotes neutralizing
T14134 4667-4675 NN denotes antibody
T14135 4676-4678 TO denotes to
T14136 4679-4683 CD denotes CD14
T14137 4684-4688 RB denotes only
T14138 4689-4698 RB denotes partially
T14139 4699-4700 -LRB- denotes (
T14140 4700-4701 FW denotes <
T14141 4701-4703 CD denotes 40
T14142 4703-4704 NN denotes %
T14143 4704-4705 -RRB- denotes )
T14144 4706-4715 VBD denotes inhibited
T14145 4716-4728 JJ denotes dCGN-induced
T14146 4729-4732 NNP denotes TNF
T14147 4733-4742 NN denotes secretion
T14148 4743-4744 -LRB- denotes (
T14149 4744-4747 RB denotes not
T14150 4748-4753 VBN denotes shown
T14151 4753-4754 -RRB- denotes )
T14152 4754-4755 . denotes .
T14153 4756-4760 CD denotes TLR4
T14154 4761-4764 VBZ denotes has
T14155 4765-4769 VBN denotes been
T14156 4770-4778 RB denotes recently
T14157 4779-4789 VBN denotes identified
T14158 4790-4792 IN denotes as
T14159 4793-4794 DT denotes a
T14160 4795-4802 NN denotes surface
T14161 4803-4811 NN denotes membrane
T14162 4812-4820 NN denotes receptor
T14163 4821-4824 IN denotes for
T14164 4825-4828 NNP denotes CGN
T14165 4829-4831 IN denotes in
T14166 4832-4837 JJ denotes human
T14167 4838-4845 JJ denotes colonic
T14168 4846-4856 JJ denotes epithelial
T14169 4857-4862 NNS denotes cells
T14170 4863-4864 NNP denotes [
T14171 4864-4866 CD denotes 41
T14172 4866-4867 NNP denotes ]
T14173 4867-4868 . denotes .
T14174 4869-4873 RB denotes Thus
T14175 4873-4874 , denotes ,
T14176 4875-4877 PRP denotes it
T14177 4878-4880 VBZ denotes is
T14178 4881-4889 JJ denotes possible
T14179 4890-4894 IN denotes that
T14180 4895-4899 CD denotes TLR4
T14181 4900-4902 VBZ denotes is
T14182 4903-4912 VBN denotes activated
T14183 4913-4915 IN denotes by
T14184 4916-4920 NNP denotes dCGN
T14185 4921-4923 TO denotes to
T14186 4924-4930 VB denotes induce
T14187 4931-4939 JJ denotes cytokine
T14188 4940-4949 NN denotes secretion
T14189 4950-4952 IN denotes by
T14190 4953-4962 NNS denotes monocytes
T14191 4962-4963 . denotes .
T14192 4964-4966 PRP denotes We
T14193 4967-4970 MD denotes can
T14194 4971-4975 RB denotes only
T14195 4976-4985 VB denotes speculate
T14196 4986-4990 IN denotes that
T14197 4991-4995 CD denotes TLR4
T14198 4996-4999 MD denotes may
T14199 5000-5004 VB denotes have
T14200 5005-5006 DT denotes a
T14201 5007-5013 JJR denotes higher
T14202 5014-5030 JJ denotes affinity-binding
T14203 5031-5035 NN denotes site
T14204 5036-5039 IN denotes for
T14205 5040-5044 NNP denotes dCGN
T14206 5045-5049 IN denotes than
T14207 5050-5053 IN denotes for
T14208 5054-5057 NNP denotes LPS
T14209 5057-5058 , denotes ,
T14210 5059-5066 RB denotes however
T14211 5066-5067 , denotes ,
T14212 5068-5072 DT denotes this
T14213 5073-5083 NN denotes hypothesis
T14214 5084-5091 VBZ denotes remains
T14215 5092-5094 TO denotes to
T14216 5095-5097 VB denotes be
T14217 5098-5104 VBN denotes tested
T14218 5104-5105 . denotes .
T14219 5106-5113 DT denotes Another
T14220 5114-5123 NN denotes indicator
T14221 5124-5128 IN denotes that
T14222 5129-5133 NNP denotes dCGN
T14223 5134-5143 VBP denotes stimulate
T14224 5144-5153 NNS denotes monocytes
T14225 5154-5161 VBG denotes leading
T14226 5162-5164 TO denotes to
T14227 5165-5166 DT denotes a
T14228 5167-5171 RBR denotes more
T14229 5172-5178 JJ denotes active
T14230 5179-5188 NN denotes phenotype
T14231 5189-5191 VBZ denotes is
T14232 5192-5195 DT denotes the
T14233 5196-5200 NN denotes fact
T14234 5201-5205 IN denotes that
T14235 5206-5213 NN denotes surface
T14236 5214-5224 NN denotes expression
T14237 5225-5227 IN denotes of
T14238 5228-5231 DT denotes the
T14239 5232-5240 NN denotes adhesion
T14240 5241-5249 NN denotes molecule
T14241 5250-5256 NN denotes ICAM-1
T14242 5257-5260 VBD denotes was
T14243 5261-5269 VBN denotes enhanced
T14244 5270-5272 IN denotes in
T14245 5273-5277 DT denotes both
T14246 5278-5281 NNP denotes PBM
T14247 5282-5285 CC denotes and
T14248 5286-5291 NNP denotes THP-1
T14249 5292-5297 NNS denotes cells
T14250 5297-5298 . denotes .
T14251 5299-5302 DT denotes The
T14252 5303-5307 IN denotes over
T14253 5308-5318 NN denotes expression
T14254 5319-5321 IN denotes of
T14255 5322-5328 NN denotes ICAM-1
T14256 5329-5335 VBD denotes caused
T14257 5336-5339 DT denotes the
T14258 5340-5349 VBN denotes activated
T14259 5350-5359 NNS denotes monocytes
T14260 5360-5362 TO denotes to
T14261 5363-5367 VB denotes form
T14262 5368-5372 NN denotes cell
T14263 5373-5383 NNS denotes aggregates
T14264 5384-5388 WDT denotes that
T14265 5389-5393 VBD denotes were
T14266 5394-5398 JJR denotes more
T14267 5399-5407 JJ denotes abundant
T14268 5408-5413 IN denotes among
T14269 5414-5419 NNS denotes cells
T14270 5420-5427 VBN denotes treated
T14271 5428-5432 IN denotes with
T14272 5433-5436 DT denotes the
T14273 5437-5439 CD denotes 40
T14274 5440-5443 NNP denotes kDa
T14275 5444-5448 NNP denotes dCGN
T14276 5448-5449 . denotes .
T14277 5450-5454 DT denotes This
T14278 5455-5465 VBZ denotes correlates
T14279 5466-5470 IN denotes with
T14280 5471-5474 DT denotes the
T14281 5475-5481 JJR denotes higher
T14282 5482-5492 NN denotes expression
T14283 5493-5495 IN denotes of
T14284 5496-5502 NN denotes ICAM-1
T14285 5503-5510 VBN denotes induced
T14286 5511-5513 IN denotes by
T14287 5514-5517 DT denotes the
T14288 5518-5520 CD denotes 40
T14289 5521-5524 NNP denotes kDa
T14290 5525-5529 NNP denotes dCGN
T14291 5529-5530 , denotes ,
T14292 5531-5541 VBG denotes suggesting
T14293 5542-5546 IN denotes that
T14294 5547-5550 DT denotes the
T14295 5551-5560 RB denotes partially
T14296 5561-5569 JJ denotes degraded
T14297 5570-5573 NNP denotes CGN
T14298 5574-5576 VBZ denotes is
T14299 5577-5581 RBR denotes more
T14300 5582-5594 RB denotes biologically
T14301 5595-5601 JJ denotes active
T14302 5601-5602 . denotes .
T14303 5603-5605 IN denotes In
T14304 5606-5614 NN denotes addition
T14305 5614-5615 , denotes ,
T14306 5616-5619 DT denotes the
T14307 5620-5624 NN denotes cell
T14308 5625-5635 NNS denotes aggregates
T14309 5636-5639 VBP denotes are
T14310 5640-5651 JJ denotes reminiscent
T14311 5652-5654 IN denotes of
T14312 5655-5663 NN denotes monocyte
T14313 5664-5674 NNS denotes aggregates
T14314 5674-5675 , denotes ,
T14315 5676-5681 WDT denotes which
T14316 5682-5686 VBP denotes form
T14317 5687-5701 JJ denotes multinucleated
T14318 5702-5707 JJ denotes giant
T14319 5708-5713 NNS denotes cells
T14320 5714-5715 -LRB- denotes (
T14321 5715-5718 NNP denotes MGC
T14322 5718-5719 -RRB- denotes )
T14323 5720-5722 IN denotes in
T14324 5723-5731 NNS denotes patients
T14325 5732-5736 IN denotes with
T14326 5737-5742 NNP denotes Crohn
T14327 5742-5744 POS denotes 's
T14328 5745-5752 NN denotes disease
T14329 5753-5754 NNP denotes [
T14330 5754-5756 CD denotes 42
T14331 5756-5757 NNP denotes ]
T14332 5757-5758 . denotes .
T14333 5759-5764 DT denotes These
T14334 5765-5770 JJ denotes giant
T14335 5771-5776 NNS denotes cells
T14336 5777-5781 VBD denotes were
T14337 5782-5785 RB denotes not
T14338 5786-5794 VBN denotes observed
T14339 5795-5797 IN denotes in
T14340 5798-5805 JJ denotes healthy
T14341 5806-5817 NNS denotes individuals
T14342 5818-5820 CC denotes or
T14343 5821-5823 IN denotes in
T14344 5824-5832 NNS denotes patients
T14345 5833-5837 IN denotes with
T14346 5838-5848 JJ denotes ulcerative
T14347 5849-5856 NNS denotes colitis
T14348 5857-5858 NNP denotes [
T14349 5858-5860 CD denotes 42
T14350 5860-5861 NNP denotes ]
T14351 5861-5862 . denotes .
T14352 5863-5871 RB denotes Moreover
T14353 5871-5872 , denotes ,
T14354 5873-5882 VBD denotes increased
T14355 5883-5893 NN denotes expression
T14356 5894-5900 NNS denotes levels
T14357 5901-5903 IN denotes of
T14358 5904-5910 NNP denotes ICAM-1
T14359 5911-5914 CC denotes and
T14360 5915-5920 NNP denotes LFA-3
T14361 5921-5922 -LRB- denotes (
T14362 5922-5926 NNP denotes CD58
T14363 5926-5927 -RRB- denotes )
T14364 5928-5932 VBD denotes were
T14365 5933-5937 RB denotes also
T14366 5938-5946 VBN denotes detected
T14367 5947-5949 IN denotes in
T14368 5950-5959 NNS denotes monocytes
T14369 5960-5964 IN denotes from
T14370 5965-5973 NNS denotes patients
T14371 5974-5978 IN denotes with
T14372 5979-5984 NNP denotes Crohn
T14373 5984-5986 POS denotes 's
T14374 5987-5994 NN denotes disease
T14375 5995-5996 NNP denotes [
T14376 5996-5998 CD denotes 43
T14377 5998-5999 NNP denotes ]
T14378 5999-6000 , denotes ,
T14379 6001-6002 NNP denotes [
T14380 6002-6004 CD denotes 44
T14381 6004-6005 NNP denotes ]
T14382 6005-6006 . denotes .
T14383 6007-6011 RB denotes Thus
T14384 6011-6012 , denotes ,
T14385 6013-6021 JJ denotes degraded
T14386 6022-6025 NNP denotes CGN
T14387 6026-6033 RB denotes clearly
T14388 6034-6037 MD denotes can
T14389 6038-6046 VB denotes activate
T14390 6047-6056 NNS denotes monocytes
T14391 6057-6059 TO denotes to
T14392 6060-6067 VB denotes express
T14393 6068-6070 DT denotes an
T14394 6071-6080 VBN denotes increased
T14395 6081-6087 NN denotes number
T14396 6088-6090 IN denotes of
T14397 6091-6097 NN denotes ICAM-1
T14398 6098-6106 NN denotes adhesion
T14399 6107-6116 NNS denotes molecules
T14400 6116-6117 , denotes ,
T14401 6118-6127 RB denotes therefore
T14402 6128-6133 VBG denotes being
T14403 6134-6141 JJ denotes capable
T14404 6142-6144 IN denotes of
T14405 6145-6153 VBG denotes creating
T14406 6154-6157 DT denotes the
T14407 6158-6168 NNS denotes conditions
T14408 6169-6183 NN denotes characteristic
T14409 6184-6186 IN denotes of
T14410 6187-6192 NNP denotes Crohn
T14411 6192-6194 POS denotes 's
T14412 6195-6202 NN denotes disease
T14413 6203-6217 NN denotes symptomatology
T14414 6217-6218 , denotes ,
T14415 6219-6223 FW denotes i.e.
T14416 6224-6227 FW denotes PBM
T14417 6228-6240 NN denotes accumulation
T14418 6241-6244 CC denotes and
T14419 6245-6248 NNP denotes MGC
T14420 6249-6258 NN denotes formation
T14421 6259-6260 NNP denotes [
T14422 6260-6262 CD denotes 45
T14423 6262-6263 NNP denotes ]
T14424 6263-6264 , denotes ,
T14425 6265-6266 NNP denotes [
T14426 6266-6268 CD denotes 46
T14427 6268-6269 NNP denotes ]
T14428 6269-6270 . denotes .
T14429 6271-6274 DT denotes The
T14430 6275-6280 JJ denotes NF-κB
T14431 6281-6288 NN denotes pathway
T14432 6289-6298 VBZ denotes regulates
T14433 6299-6304 NNS denotes genes
T14434 6305-6316 JJ denotes responsible
T14435 6317-6320 IN denotes for
T14436 6321-6327 NNP denotes ICAM-1
T14437 6328-6331 CC denotes and
T14438 6332-6337 NNP denotes TNF-α
T14439 6338-6348 NN denotes expression
T14440 6348-6349 . denotes .
T14441 6350-6355 JJ denotes NF-κB
T14442 6356-6366 NN denotes activation
T14443 6367-6369 VBZ denotes is
T14444 6370-6380 VBN denotes associated
T14445 6381-6385 IN denotes with
T14446 6386-6389 DT denotes the
T14447 6390-6401 NN denotes degradation
T14448 6402-6404 IN denotes of
T14449 6405-6408 DT denotes the
T14450 6409-6418 NN denotes inhibitor
T14451 6419-6426 NN denotes protein
T14452 6427-6430 NNP denotes IκB
T14453 6431-6432 NNP denotes [
T14454 6432-6434 CD denotes 47
T14455 6434-6435 NNP denotes ]
T14456 6435-6436 . denotes .
T14457 6437-6443 RB denotes Indeed
T14458 6443-6444 , denotes ,
T14459 6445-6449 NNP denotes dCGN
T14460 6450-6457 VBD denotes induced
T14461 6458-6463 NNP denotes NF-κB
T14462 6464-6474 NN denotes activation
T14463 6475-6477 IN denotes as
T14464 6478-6483 VBN denotes shown
T14465 6484-6486 IN denotes by
T14466 6487-6498 NN denotes degradation
T14467 6499-6501 IN denotes of
T14468 6502-6506 NNP denotes IκBα
T14469 6506-6507 , denotes ,
T14470 6508-6521 NN denotes translocation
T14471 6522-6524 IN denotes of
T14472 6525-6528 CD denotes p65
T14473 6529-6532 CC denotes and
T14474 6533-6536 CD denotes p50
T14475 6537-6546 NNS denotes sub-units
T14476 6547-6549 TO denotes to
T14477 6550-6553 DT denotes the
T14478 6554-6561 NN denotes nucleus
T14479 6562-6565 CC denotes and
T14480 6566-6568 IN denotes by
T14481 6569-6579 NN denotes activation
T14482 6580-6582 IN denotes of
T14483 6583-6585 DT denotes an
T14484 6586-6602 JJ denotes NF-κB-responsive
T14485 6603-6613 NN denotes luciferase
T14486 6614-6622 NN denotes reporter
T14487 6623-6630 NN denotes plasmid
T14488 6630-6631 . denotes .
T14489 6632-6637 RB denotes Again
T14490 6637-6638 , denotes ,
T14491 6639-6640 DT denotes a
T14492 6641-6649 JJR denotes stronger
T14493 6650-6660 NN denotes activation
T14494 6661-6663 IN denotes of
T14495 6664-6669 NN denotes NF-κB
T14496 6670-6673 VBD denotes was
T14497 6674-6681 VBN denotes induced
T14498 6682-6684 IN denotes by
T14499 6685-6688 DT denotes the
T14500 6689-6691 CD denotes 40
T14501 6692-6695 NNP denotes kDa
T14502 6696-6700 NNP denotes dCGN
T14503 6701-6709 VBD denotes compared
T14504 6710-6712 TO denotes to
T14505 6713-6715 CD denotes 10
T14506 6716-6719 NNP denotes kDa
T14507 6720-6724 NNP denotes dCGN
T14508 6724-6725 , denotes ,
T14509 6726-6736 VBG denotes suggesting
T14510 6737-6741 IN denotes that
T14511 6742-6745 DT denotes the
T14512 6746-6755 RB denotes partially
T14513 6756-6764 JJ denotes degraded
T14514 6765-6768 NNP denotes CGN
T14515 6769-6771 VBZ denotes is
T14516 6772-6776 RBR denotes more
T14517 6777-6789 RB denotes biologically
T14518 6790-6796 JJ denotes active
T14519 6796-6797 . denotes .
T14520 6798-6801 PRP$ denotes Our
T14521 6802-6806 NNS denotes data
T14522 6807-6810 VBP denotes are
T14523 6811-6813 IN denotes in
T14524 6814-6823 NN denotes agreement
T14525 6824-6828 IN denotes with
T14526 6829-6830 DT denotes a
T14527 6831-6839 JJ denotes previous
T14528 6840-6845 NN denotes study
T14529 6846-6853 VBG denotes showing
T14530 6854-6858 IN denotes that
T14531 6859-6865 JJ denotes native
T14532 6866-6869 NNP denotes CGN
T14533 6870-6874 RB denotes also
T14534 6875-6882 VBD denotes induced
T14535 6883-6893 NN denotes activation
T14536 6894-6896 IN denotes of
T14537 6897-6902 NN denotes NF-κB
T14538 6903-6905 IN denotes in
T14539 6906-6911 JJ denotes human
T14540 6912-6919 JJ denotes colonic
T14541 6920-6930 JJ denotes epithelial
T14542 6931-6936 NNS denotes cells
T14543 6937-6938 NNP denotes [
T14544 6938-6940 CD denotes 48
T14545 6940-6941 NNP denotes ]
T14546 6941-6942 . denotes .
T14547 6943-6948 JJ denotes NF-κB
T14548 6949-6956 NN denotes pathway
T14549 6957-6959 VBZ denotes is
T14550 6960-6965 RB denotes often
T14551 6966-6976 VBN denotes associated
T14552 6977-6979 TO denotes to
T14553 6980-6987 VB denotes promote
T14554 6988-6992 NN denotes cell
T14555 6993-7001 NN denotes survival
T14556 7002-7005 CC denotes and
T14557 7006-7012 NN denotes cancer
T14558 7013-7017 NN denotes cell
T14559 7018-7024 NN denotes growth
T14560 7024-7025 , denotes ,
T14561 7026-7033 RB denotes however
T14562 7034-7036 PRP denotes it
T14563 7037-7040 VBZ denotes has
T14564 7041-7045 VBN denotes been
T14565 7046-7055 RB denotes sometimes
T14566 7056-7064 VBN denotes reported
T14567 7065-7067 TO denotes to
T14568 7068-7074 VB denotes behave
T14569 7075-7077 IN denotes as
T14570 7078-7079 DT denotes a
T14571 7080-7085 NN denotes tumor
T14572 7086-7096 NN denotes suppressor
T14573 7096-7097 , denotes ,
T14574 7098-7107 VBG denotes arresting
T14575 7108-7112 NN denotes cell
T14576 7113-7126 NN denotes proliferation
T14577 7127-7128 NNP denotes [
T14578 7128-7130 CD denotes 49
T14579 7130-7131 NNP denotes ]
T14580 7131-7132 . denotes .
T14581 7133-7137 JJ denotes Such
T14582 7138-7150 NN denotes relationship
T14583 7151-7158 IN denotes between
T14584 7159-7164 NNP denotes NF-kB
T14585 7165-7175 NN denotes activation
T14586 7176-7179 CC denotes and
T14587 7180-7184 NN denotes cell
T14588 7185-7190 NN denotes cycle
T14589 7191-7201 NN denotes regulation
T14590 7202-7205 VBZ denotes has
T14591 7206-7210 VBN denotes been
T14592 7211-7219 VBN denotes reported
T14593 7220-7222 IN denotes in
T14594 7223-7229 JJ denotes normal
T14595 7230-7235 JJ denotes human
T14596 7236-7245 JJ denotes epidermal
T14597 7246-7251 NNS denotes cells
T14598 7252-7253 NNP denotes [
T14599 7253-7255 CD denotes 50
T14600 7255-7256 NNP denotes ]
T14601 7256-7257 . denotes .
T14602 7258-7264 RB denotes Indeed
T14603 7264-7265 , denotes ,
T14604 7266-7268 PRP denotes it
T14605 7269-7272 VBZ denotes has
T14606 7273-7277 VBN denotes been
T14607 7278-7283 VBN denotes shown
T14608 7284-7288 IN denotes that
T14609 7289-7294 JJ denotes NF-κB
T14610 7295-7305 NN denotes activation
T14611 7306-7316 VBN denotes suppressed
T14612 7317-7321 CD denotes cdk4
T14613 7322-7332 NN denotes expression
T14614 7332-7333 , denotes ,
T14615 7334-7339 WDT denotes which
T14616 7340-7342 VBZ denotes is
T14617 7343-7352 JJ denotes necessary
T14618 7353-7356 IN denotes for
T14619 7357-7360 DT denotes the
T14620 7361-7371 NN denotes transition
T14621 7372-7374 TO denotes to
T14622 7375-7376 NNP denotes S
T14623 7377-7382 NN denotes phase
T14624 7382-7383 . denotes .
T14625 7384-7391 RB denotes Finally
T14626 7391-7392 , denotes ,
T14627 7393-7398 JJ denotes NF-κB
T14628 7399-7409 NN denotes activation
T14629 7410-7413 VBD denotes was
T14630 7414-7422 VBN denotes reported
T14631 7423-7425 TO denotes to
T14632 7426-7432 VB denotes induce
T14633 7433-7439 NN denotes growth
T14634 7440-7446 NN denotes arrest
T14635 7447-7449 IN denotes in
T14636 7450-7456 JJ denotes normal
T14637 7457-7462 JJ denotes human
T14638 7463-7476 NNS denotes keratinocytes
T14639 7477-7479 IN denotes by
T14640 7480-7481 DT denotes a
T14641 7482-7491 NNS denotes mechanims
T14642 7492-7501 VBG denotes involving
T14643 7502-7505 DT denotes the
T14644 7506-7509 NN denotes cdk
T14645 7510-7519 NN denotes inhibitor
T14646 7520-7523 CD denotes p21
T14647 7524-7525 NNP denotes [
T14648 7525-7527 CD denotes 51
T14649 7527-7528 NNP denotes ]
T14650 7528-7529 . denotes .
T14651 7530-7533 DT denotes The
T14652 7534-7541 NNS denotes effects
T14653 7542-7544 IN denotes of
T14654 7545-7549 NNP denotes dCGN
T14655 7550-7552 IN denotes on
T14656 7553-7556 CD denotes p21
T14657 7557-7560 CC denotes and
T14658 7561-7565 CD denotes cdk4
T14659 7566-7576 NN denotes expression
T14660 7577-7583 VBP denotes remain
T14661 7584-7586 TO denotes to
T14662 7587-7589 VB denotes be
T14663 7590-7597 VBN denotes studied
T14664 7597-7598 . denotes .
T14665 7599-7601 IN denotes In
T14666 7602-7607 DT denotes these
T14667 7608-7615 NNS denotes studies
T14668 7615-7616 , denotes ,
T14669 7617-7619 PRP denotes we
T14670 7620-7624 VBP denotes have
T14671 7625-7637 VBN denotes demonstrated
T14672 7638-7639 DT denotes a
T14673 7640-7646 JJ denotes direct
T14674 7647-7653 NN denotes action
T14675 7654-7656 IN denotes of
T14676 7657-7661 NNP denotes dCGN
T14677 7662-7664 IN denotes on
T14678 7665-7674 NNS denotes monocytes
T14679 7674-7675 . denotes .
T14680 7676-7685 NNS denotes Monocytes
T14681 7686-7693 VBN denotes exposed
T14682 7694-7696 TO denotes to
T14683 7697-7701 NNP denotes dCGN
T14684 7702-7710 VBD denotes acquired
T14685 7711-7713 DT denotes an
T14686 7714-7726 JJ denotes inflammatory
T14687 7727-7736 NN denotes phenotype
T14688 7737-7741 WDT denotes that
T14689 7742-7750 VBD denotes included
T14690 7751-7757 JJR denotes higher
T14691 7758-7768 NN denotes expression
T14692 7769-7771 IN denotes of
T14693 7772-7775 DT denotes the
T14694 7776-7784 NN denotes adhesion
T14695 7785-7793 NN denotes molecule
T14696 7794-7800 NN denotes ICAM-1
T14697 7801-7804 CC denotes and
T14698 7805-7810 JJ denotes TNF-α
T14699 7811-7821 NN denotes production
T14700 7821-7822 , denotes ,
T14701 7823-7826 IN denotes via
T14702 7827-7830 DT denotes the
T14703 7831-7836 NNP denotes NF-κB
T14704 7837-7844 NN denotes pathway
T14705 7844-7845 . denotes .
T14706 7846-7850 DT denotes This
T14707 7851-7857 JJR denotes higher
T14708 7858-7868 NN denotes expression
T14709 7869-7871 IN denotes of
T14710 7872-7878 NNP denotes ICAM-1
T14711 7879-7887 VBD denotes resulted
T14712 7888-7890 IN denotes in
T14713 7891-7900 NN denotes formation
T14714 7901-7903 IN denotes of
T14715 7904-7908 NN denotes cell
T14716 7909-7919 NNS denotes aggregates
T14717 7920-7927 JJ denotes similar
T14718 7928-7930 TO denotes to
T14719 7931-7936 DT denotes those
T14720 7937-7945 VBN denotes observed
T14721 7946-7948 IN denotes in
T14722 7949-7957 NNS denotes patients
T14723 7958-7962 IN denotes with
T14724 7963-7968 NNP denotes Crohn
T14725 7968-7970 POS denotes 's
T14726 7971-7978 NN denotes disease
T14727 7978-7979 . denotes .
T14728 7980-7982 PRP denotes We
T14729 7983-7990 VBP denotes presume
T14730 7991-7995 IN denotes that
T14731 7996-7999 DT denotes the
T14732 8000-8012 JJ denotes differential
T14733 8013-8020 NNS denotes effects
T14734 8021-8023 IN denotes of
T14735 8024-8026 CD denotes 10
T14736 8027-8030 CC denotes and
T14737 8031-8033 CD denotes 40
T14738 8034-8037 NNP denotes kDa
T14739 8038-8042 NNP denotes dCGN
T14740 8043-8045 TO denotes to
T14741 8046-8052 VB denotes induce
T14742 8053-8058 DT denotes these
T14743 8059-8066 NNS denotes effects
T14744 8067-8069 IN denotes on
T14745 8070-8079 NNS denotes monocytes
T14746 8080-8083 VBP denotes are
T14747 8084-8091 RB denotes tightly
T14748 8092-8098 VBN denotes linked
T14749 8099-8101 TO denotes to
T14750 8102-8107 PRP$ denotes their
T14751 8108-8116 NN denotes capacity
T14752 8117-8119 TO denotes to
T14753 8120-8126 VB denotes induce
T14754 8127-8139 NN denotes inflammation
T14755 8140-8142 IN denotes in
T14756 8143-8147 NN denotes vivo
T14757 8147-8148 . denotes .
T14758 8149-8156 RB denotes However
T14759 8156-8157 , denotes ,
T14760 8158-8160 IN denotes in
T14761 8161-8165 NN denotes vivo
T14762 8165-8166 , denotes ,
T14763 8167-8178 NNS denotes macrophages
T14764 8179-8181 VBP denotes do
T14765 8182-8185 RB denotes not
T14766 8186-8190 VBN denotes come
T14767 8191-8193 IN denotes in
T14768 8194-8200 JJ denotes direct
T14769 8201-8208 NN denotes contact
T14770 8209-8213 IN denotes with
T14771 8214-8217 DT denotes the
T14772 8218-8228 JJ denotes intestinal
T14773 8229-8234 NNS denotes lumen
T14774 8235-8238 CC denotes and
T14775 8239-8242 VBP denotes are
T14776 8243-8252 VBN denotes separated
T14777 8253-8255 IN denotes by
T14778 8256-8259 DT denotes the
T14779 8260-8270 JJ denotes epithelial
T14780 8271-8278 NN denotes barrier
T14781 8278-8279 . denotes .
T14782 8280-8283 DT denotes The
T14783 8284-8287 NN denotes way
T14784 8288-8290 IN denotes by
T14785 8291-8296 WDT denotes which
T14786 8297-8301 NNP denotes dCGN
T14787 8302-8305 MD denotes may
T14788 8306-8311 VB denotes leave
T14789 8312-8315 DT denotes the
T14790 8316-8326 JJ denotes intestinal
T14791 8327-8332 NNS denotes lumen
T14792 8333-8336 CC denotes and
T14793 8337-8342 VB denotes cross
T14794 8343-8346 DT denotes the
T14795 8347-8357 JJ denotes epithelial
T14796 8358-8365 NN denotes barrier
T14797 8366-8368 TO denotes to
T14798 8369-8374 VB denotes reach
T14799 8375-8378 DT denotes the
T14800 8379-8390 NNS denotes macrophages
T14801 8391-8393 VBZ denotes is
T14802 8394-8396 DT denotes an
T14803 8397-8407 JJ denotes intriguing
T14804 8408-8412 JJ denotes open
T14805 8413-8421 NN denotes question
T14806 8421-8422 . denotes .
T14807 8423-8426 CD denotes One
T14808 8427-8435 JJ denotes possible
T14809 8436-8447 NN denotes explanation
T14810 8448-8455 VBZ denotes resides
T14811 8456-8458 IN denotes in
T14812 8459-8462 DT denotes the
T14813 8463-8472 NN denotes potential
T14814 8473-8475 IN denotes of
T14815 8476-8480 NNP denotes dCGN
T14816 8481-8483 TO denotes to
T14817 8485-8491 VB denotes induce
T14818 8493-8501 JJ denotes cellular
T14819 8502-8505 CC denotes and
T14820 8506-8518 JJ denotes paracellular
T14821 8519-8528 JJ denotes injurious
T14822 8529-8536 NNS denotes effects
T14823 8537-8539 IN denotes at
T14824 8540-8543 DT denotes the
T14825 8544-8554 JJ denotes intestinal
T14826 8555-8565 JJ denotes epithelial
T14827 8566-8570 NN denotes cell
T14828 8571-8580 NN denotes monolayer
T14829 8581-8582 NNP denotes [
T14830 8582-8584 CD denotes 48
T14831 8584-8585 NNP denotes ]
T14832 8585-8586 . denotes .
T14833 8587-8589 IN denotes In
T14834 8590-8600 NN denotes conclusion
T14835 8600-8601 , denotes ,
T14836 8602-8606 NNP denotes dCGN
T14837 8607-8616 VBD denotes inhibited
T14838 8617-8622 CD denotes THP-1
T14839 8623-8627 NN denotes cell
T14840 8628-8641 NN denotes proliferation
T14841 8642-8644 IN denotes in
T14842 8645-8650 NN denotes vitro
T14843 8650-8651 , denotes ,
T14844 8652-8664 VBG denotes accumulating
T14845 8665-8668 DT denotes the
T14846 8669-8674 NNS denotes cells
T14847 8675-8677 IN denotes in
T14848 8678-8681 DT denotes the
T14849 8682-8684 NNP denotes G1
T14850 8685-8690 NN denotes phase
T14851 8691-8693 IN denotes of
T14852 8694-8697 DT denotes the
T14853 8698-8702 NN denotes cell
T14854 8703-8708 NN denotes cycle
T14855 8708-8709 , denotes ,
T14856 8710-8719 VBD denotes increased
T14857 8720-8726 NNP denotes ICAM-1
T14858 8727-8737 NN denotes expression
T14859 8737-8738 , denotes ,
T14860 8739-8749 VBN denotes stimulated
T14861 8750-8766 JJ denotes ICAM-1-dependent
T14862 8767-8775 NN denotes monocyte
T14863 8776-8787 NN denotes aggregation
T14864 8788-8790 IN denotes in
T14865 8791-8796 NN denotes vitro
T14866 8796-8797 , denotes ,
T14867 8798-8801 CC denotes and
T14868 8802-8812 VBD denotes stimulated
T14869 8813-8818 NNP denotes TNF-α
T14870 8819-8829 NN denotes expression
T14871 8830-8833 CC denotes and
T14872 8834-8843 NN denotes secretion
T14873 8843-8844 . denotes .
T14874 8845-8850 DT denotes These
T14875 8851-8860 NNS denotes responses
T14876 8861-8865 VBD denotes were
T14877 8866-8870 RBR denotes more
T14878 8871-8881 JJ denotes pronounced
T14879 8882-8891 VBG denotes following
T14880 8892-8894 CD denotes 40
T14881 8895-8898 NNP denotes kDa
T14882 8899-8903 NNP denotes dCGN
T14883 8903-8904 , denotes ,
T14884 8905-8908 CC denotes and
T14885 8909-8913 VBD denotes were
T14886 8914-8917 DT denotes all
T14887 8918-8924 VBN denotes linked
T14888 8925-8927 TO denotes to
T14889 8928-8933 NNP denotes NF-κB
T14890 8934-8944 NN denotes activation
T14891 8944-8945 . denotes .
T14892 8946-8951 DT denotes These
T14893 8952-8959 NNS denotes results
T14894 8960-8967 VBP denotes suggest
T14895 8968-8972 IN denotes that
T14896 8972-8973 , denotes ,
T14897 8974-8982 IN denotes although
T14898 8983-8986 NNP denotes CGN
T14899 8987-8989 VBZ denotes is
T14900 8990-8996 RB denotes widely
T14901 8997-9001 VBN denotes used
T14902 9002-9004 IN denotes as
T14903 9005-9006 DT denotes a
T14904 9007-9011 NN denotes food
T14905 9012-9020 JJ denotes additive
T14906 9020-9021 , denotes ,
T14907 9022-9025 PRP$ denotes its
T14908 9026-9034 JJ denotes degraded
T14909 9035-9040 NNS denotes forms
T14910 9041-9045 VBP denotes have
T14911 9046-9048 DT denotes an
T14912 9049-9058 JJ denotes important
T14913 9059-9065 NN denotes effect
T14914 9066-9068 IN denotes on
T14915 9069-9078 NNS denotes monocytes
T14916 9079-9093 JJ denotes characteristic
T14917 9094-9096 IN denotes of
T14918 9097-9099 DT denotes an
T14919 9100-9112 JJ denotes inflammatory
T14920 9113-9122 NN denotes phenotype
T14921 9122-9123 . denotes .
R11440 T13291 T13283 appos ],infiltration
R11441 T13292 T13281 punct .,associated
R11442 T13293 T13294 det These,macrophages
R11443 T13294 T13295 nsubj macrophages,are
R11444 T13295 T13295 ROOT are,are
R11445 T13296 T13295 acomp able,are
R11446 T13297 T13298 aux to,initiate
R11447 T13298 T13296 xcomp initiate,able
R11448 T13299 T13300 amod immune,responses
R11449 T13300 T13298 dobj responses,initiate
R11450 T13301 T13298 cc and,initiate
R11451 T13302 T13304 aux can,induced
R11452 T13303 T13304 auxpass be,induced
R11453 T13304 T13295 conj induced,are
R11454 T13305 T13306 aux to,differentiate
R11455 T13306 T13304 advcl differentiate,induced
R11456 T13307 T13306 prep into,differentiate
R11457 T13308 T13307 pobj cells,into
R11458 T13309 T13311 nsubj that,exacerbate
R11459 T13310 T13311 preconj either,exacerbate
R11460 T13311 T13308 relcl exacerbate,cells
R11461 T13312 T13311 cc or,exacerbate
R11462 T13313 T13311 conj inhibit,exacerbate
R11463 T13314 T13315 det the,inflammation
R11482 T13333 T13334 amod intestinal,mucosa
R11483 T13334 T13331 pobj mucosa,in
R11484 T13335 T13340 prep during,followed
R11485 T13336 T13335 pobj inflammation,during
R11502 T13353 T13353 ROOT induce,induce
R11503 T13354 T13355 det these,leukocytes
R11504 T13355 T13353 dobj leukocytes,induce
R11505 T13356 T13357 aux to,produce
R11506 T13357 T13353 xcomp produce,induce
R11507 T13358 T13357 cc and,produce
R11508 T13359 T13357 conj secrete,produce
R11509 T13360 T13359 dobj cytokines,secrete
R11510 T13361 T13359 prep during,secrete
R11511 T13362 T13361 pobj inflammation,during
R11512 T13363 T13353 punct .,induce
R11513 T13364 T13375 nsubj One,is
R11514 T13365 T13364 prep of,One
R11515 T13366 T13371 det the,stimuli
R11516 T13367 T13368 advmod most,potent
R11517 T13368 T13371 amod potent,stimuli
R11518 T13369 T13368 cc and,potent
R11519 T13370 T13368 conj known,potent
R11520 T13371 T13365 pobj stimuli,of
R11521 T13372 T13371 prep for,stimuli
R11522 T13373 T13374 compound leukocyte,activation
R11523 T13374 T13372 pobj activation,for
R11524 T13375 T13375 ROOT is,is
R11525 T13376 T13375 attr LPS,is
R11526 T13377 T13376 prep from,LPS
R11527 T13378 T13379 amod Gram-negative,bacteria
R11528 T13379 T13377 pobj bacteria,from
R11529 T13380 T13382 nmod [,]
R11530 T13381 T13382 nummod 34,]
R11531 T13382 T13379 appos ],bacteria
R11532 T13383 T13375 punct .,is
R11533 T13384 T13389 prep In,are
R11534 T13385 T13384 pobj addition,In
R11535 T13386 T13389 punct ",",are
R11536 T13387 T13388 amod other,factors
R11537 T13388 T13389 nsubj factors,are
R11538 T13389 T13389 ROOT are,are
R11539 T13390 T13389 advmod also,are
R11540 T13391 T13389 acomp able,are
R11541 T13392 T13393 aux to,stimulate
R11542 T13393 T13391 xcomp stimulate,able
R11543 T13394 T13395 amod cytokine,secretion
R11544 T13395 T13393 dobj secretion,stimulate
R11545 T13396 T13393 prep from,stimulate
R11546 T13397 T13398 amod various,leukocytes
R11547 T13398 T13396 pobj leukocytes,from
R11548 T13399 T13401 nmod [,]
R11549 T13400 T13401 nummod 35,]
R11550 T13401 T13393 dobj ],stimulate
R11551 T13402 T13401 punct ",",]
R11552 T13403 T13405 compound [,]
R11553 T13404 T13405 nummod 36,]
R11554 T13405 T13401 appos ],]
R11555 T13406 T13389 punct .,are
R11556 T13407 T13409 nummod One,factor
R11557 T13408 T13409 amod such,factor
R11558 T13409 T13410 nsubj factor,is
R11559 T13410 T13410 ROOT is,is
R11560 T13411 T13410 attr CGN,is
R11561 T13412 T13411 punct ",",CGN
R11562 T13413 T13416 det a,weight
R11563 T13414 T13416 amod high,weight
R11564 T13415 T13416 amod molecular,weight
R11565 T13416 T13411 appos weight,CGN
R11566 T13417 T13418 amod sulphated,polysaccharide
R11567 T13418 T13411 appos polysaccharide,CGN
R11568 T13419 T13420 punct (,>
R11569 T13420 T13411 appos >,CGN
R11570 T13421 T13422 nummod 200,kDa
R11571 T13422 T13420 appos kDa,>
R11572 T13423 T13420 punct ),>
R11573 T13424 T13411 acl derived,CGN
R11574 T13425 T13424 prep from,derived
R11575 T13426 T13427 amod red,algae
R11576 T13427 T13425 pobj algae,from
R11577 T13428 T13427 punct (,algae
R11578 T13429 T13427 appos Rhodophyceae,algae
R11579 T13430 T13427 punct ),algae
R11580 T13431 T13433 nmod [,]
R11581 T13432 T13433 nummod 1,]
R11582 T13433 T13411 conj ],CGN
R11583 T13434 T13433 punct ",",]
R11584 T13435 T13437 nmod [,]
R11585 T13436 T13437 nummod 2,]
R11586 T13437 T13433 conj ],]
R11587 T13438 T13410 punct .,is
R11588 T13439 T13440 amod Native,CGN
R11589 T13440 T13443 nsubjpass CGN,used
R11590 T13441 T13443 auxpass is,used
R11591 T13442 T13443 advmod widely,used
R11592 T13443 T13443 ROOT used,used
R11593 T13444 T13443 prep as,used
R11594 T13445 T13447 det a,additive
R11595 T13446 T13447 compound food,additive
R11596 T13447 T13444 pobj additive,as
R11597 T13448 T13449 punct (,E
R11598 T13449 T13447 appos E,additive
R11599 T13450 T13449 nummod 407,E
R11600 T13451 T13447 punct ),additive
R11601 T13452 T13453 aux to,improve
R11602 T13453 T13443 xcomp improve,used
R11603 T13454 T13453 dobj texture,improve
R11604 T13455 T13443 punct .,used
R11605 T13456 T13459 nsubjpass It,used
R11606 T13457 T13459 auxpass is,used
R11607 T13458 T13459 advmod also,used
R11608 T13459 T13459 ROOT used,used
R11609 T13460 T13459 prep in,used
R11610 T13461 T13460 pobj cosmetics,in
R11611 T13462 T13461 cc and,cosmetics
R11612 T13463 T13461 conj pharmaceuticals,cosmetics
R11613 T13464 T13459 punct .,used
R11614 T13465 T13476 mark Although,declared
R11615 T13466 T13467 amod native,form
R11616 T13467 T13468 compound form,CGN
R11617 T13468 T13476 nsubjpass CGN,declared
R11618 T13469 T13468 punct (,CGN
R11619 T13470 T13468 npadvmod 200,CGN
R11620 T13471 T13472 nummod 800,kDa
R11621 T13472 T13468 appos kDa,CGN
R11622 T13473 T13472 punct ),kDa
R11623 T13474 T13476 aux has,declared
R11624 T13475 T13476 auxpass been,declared
R11625 T13476 T13500 advcl declared,used
R11626 T13477 T13476 oprd harmless,declared
R11627 T13478 T13477 prep to,harmless
R11628 T13479 T13478 pobj humans,to
R11629 T13480 T13482 nmod [,]
R11630 T13481 T13482 nummod 8,]
R11631 T13482 T13500 nsubjpass ],used
R11632 T13483 T13482 punct ",",]
R11633 T13484 T13486 poss its,forms
R11634 T13485 T13486 amod degraded,forms
R11635 T13486 T13482 conj forms,]
R11636 T13487 T13486 punct (,forms
R11637 T13488 T13486 appos <,forms
R11638 T13489 T13490 nummod 50,kDa
R11639 T13490 T13488 prep kDa,<
R11640 T13491 T13486 punct ),forms
R11641 T13492 T13482 punct ",",]
R11642 T13493 T13494 advmod also,known
R11643 T13494 T13482 acl known,]
R11644 T13495 T13494 prep as,known
R11645 T13496 T13495 pobj poligeenan,as
R11646 T13497 T13500 punct ",",used
R11647 T13498 T13500 auxpass are,used
R11648 T13499 T13500 advmod widely,used
R11649 T13500 T13500 ROOT used,used
R11650 T13501 T13502 aux to,induce
R11651 T13502 T13500 xcomp induce,used
R11652 T13503 T13502 dobj colitis,induce
R11653 T13504 T13502 prep in,induce
R11654 T13505 T13504 pobj rodents,in
R11655 T13506 T13502 conj [,induce
R11656 T13507 T13508 nummod 3,]
R11657 T13508 T13506 dobj ],[
R11658 T13509 T13508 appos [,]
R11659 T13510 T13509 nummod 5,[
R11660 T13511 T13509 appos ],[
R11661 T13512 T13500 punct .,used
R11662 T13513 T13515 det These,CGN
R11663 T13514 T13515 amod degraded,CGN
R11664 T13515 T13518 nsubj CGN,have
R11665 T13516 T13518 aux may,have
R11666 T13517 T13518 advmod also,have
R11667 T13518 T13536 ccomp have,is
R11668 T13519 T13525 det a,]
R11669 T13520 T13525 amod possible,]
R11670 T13521 T13522 amod carcinogenic,effect
R11671 T13522 T13525 nmod effect,]
R11672 T13523 T13525 nmod [,]
R11673 T13524 T13523 nummod 4,[
R11674 T13525 T13518 dobj ],have
R11675 T13526 T13525 punct ",",]
R11676 T13527 T13525 conj [,]
R11677 T13528 T13529 nummod 6,]
R11678 T13529 T13532 nmod ],]
R11679 T13530 T13532 nmod [,]
R11680 T13531 T13532 nummod 8,]
R11681 T13532 T13525 conj ],]
R11682 T13533 T13536 punct ;,is
R11683 T13534 T13536 advmod however,is
R11684 T13535 T13536 nsubj this,is
R11685 T13536 T13536 ROOT is,is
R11686 T13537 T13536 advmod still,is
R11687 T13538 T13536 acomp controversial,is
R11688 T13539 T13536 punct .,is
R11689 T13540 T13552 mark Although,required
R11690 T13541 T13542 compound acid,treatment
R11691 T13542 T13552 nsubjpass treatment,required
R11693 T13543 T13542 prep at,treatment
R11694 T13544 T13545 amod high,temperature
R11695 T13545 T13543 pobj temperature,at
R11696 T13619 T13620 det the,role
R11697 T13546 T13545 punct (,temperature
R11698 T13620 T13618 dobj role,analyzed
R11699 T13547 T13549 nummod 80,C
R11700 T13548 T13549 nummod °,C
R11701 T13549 T13542 npadvmod C,treatment
R11702 T13621 T13620 prep of,role
R11703 T13550 T13542 punct ),treatment
R11704 T13622 T13623 amod human,monocytes
R11705 T13551 T13552 auxpass is,required
R11706 T13552 T13565 advcl required,is
R11707 T13623 T13621 pobj monocytes,of
R11708 T13624 T13623 punct (,monocytes
R11709 T13553 T13552 prep for,required
R11710 T13625 T13623 appos PBM,monocytes
R11711 T13626 T13625 cc and,PBM
R11712 T13554 T13555 compound CGN,hydrolysis
R11713 T13627 T13625 conj THP-1,PBM
R11714 T13555 T13553 pobj hydrolysis,for
R11715 T13628 T13623 punct ),monocytes
R11716 T13629 T13620 prep in,role
R11717 T13630 T13631 amod dCGN-induced,inflammation
R11718 T13631 T13629 pobj inflammation,in
R11719 T13556 T13552 prep in,required
R11720 T13632 T13618 punct .,analyzed
R11721 T13633 T13642 nsubj Preliminary,revealed
R11722 T13634 T13633 prep in,Preliminary
R11723 T13635 T13636 compound vivo,studies
R11724 T13557 T13556 pobj vitro,in
R11725 T13636 T13634 pobj studies,in
R11726 T13558 T13562 prep to,dCGN
R11727 T13637 T13636 prep in,studies
R11728 T13559 T13561 amod lower,weight
R11729 T13560 T13561 amod molecular,weight
R11730 T13561 T13558 pobj weight,to
R11731 T13638 T13637 pobj rats,in
R11732 T13562 T13565 intj dCGN,is
R11733 T13563 T13565 punct ",",is
R11734 T13639 T13638 acl treated,rats
R11735 T13564 T13565 nsubj it,is
R11736 T13640 T13639 prep with,treated
R11737 T13565 T13565 ROOT is,is
R11738 T13566 T13565 acomp probable,is
R11739 T13641 T13640 pobj dCGN,with
R11740 T13567 T13571 mark that,produced
R11741 T13642 T13642 ROOT revealed,revealed
R11742 T13568 T13569 det some,dCGN
R11743 T13569 T13571 nsubjpass dCGN,produced
R11744 T13643 T13644 amod significant,shortening
R11745 T13570 T13571 auxpass are,produced
R11746 T13644 T13642 dobj shortening,revealed
R11747 T13571 T13565 ccomp produced,is
R11748 T13645 T13644 prep of,shortening
R11749 T13572 T13571 prep by,produced
R11750 T13573 T13574 compound acid,hydrolysis
R11751 T13646 T13648 det the,intestine
R11752 T13574 T13572 pobj hydrolysis,by
R11753 T13647 T13648 amod large,intestine
R11754 T13575 T13571 prep during,produced
R11755 T13576 T13577 amod gastric,digestion
R11756 T13648 T13645 pobj intestine,of
R11757 T13577 T13575 pobj digestion,during
R11758 T13649 T13648 acl associated,intestine
R11759 T13578 T13580 nmod [,]
R11760 T13579 T13580 nummod 9,]
R11761 T13650 T13649 prep with,associated
R11762 T13580 T13577 nmod ],digestion
R11763 T13651 T13653 det an,state
R11764 T13581 T13580 punct ",",]
R11765 T13582 T13580 appos [,]
R11766 T13652 T13653 amod inflammatory,state
R11767 T13653 T13650 pobj state,with
R11768 T13654 T13648 punct ",",intestine
R11769 T13583 T13584 nummod 10,]
R11770 T13655 T13656 advmod i.e.,strong
R11771 T13656 T13657 amod strong,infiltration
R11772 T13657 T13645 pobj infiltration,of
R11773 T13584 T13580 conj ],]
R11774 T13658 T13657 prep of,infiltration
R11775 T13659 T13658 pobj macrophages,of
R11776 T13660 T13642 prep to,revealed
R11777 T13585 T13584 cc or,]
R11778 T13661 T13663 det the,mucosa
R11779 T13662 T13663 amod intestinal,mucosa
R11780 T13663 T13660 pobj mucosa,to
R11781 T13586 T13584 conj interaction,]
R11782 T13664 T13660 amod similar,to
R11783 T13665 T13664 prep to,similar
R11784 T13666 T13667 amod DSS-induced,inflammation
R11785 T13587 T13586 prep with,interaction
R11786 T13667 T13665 pobj inflammation,to
R11787 T13668 T13660 pobj [,to
R11788 T13669 T13670 nummod 20,]
R11789 T13588 T13589 amod intestinal,bacteria
R11790 T13670 T13668 dobj ],[
R11791 T13671 T13642 punct .,revealed
R11792 T13589 T13587 pobj bacteria,with
R11793 T13672 T13685 advcl Using,observed
R11794 T13673 T13674 nummod two,fractions
R11795 T13674 T13672 dobj fractions,Using
R11796 T13590 T13592 compound [,]
R11797 T13675 T13674 prep of,fractions
R11798 T13676 T13675 pobj dCGN,of
R11799 T13677 T13676 punct (,dCGN
R11800 T13591 T13592 compound 11,]
R11801 T13678 T13676 nummod 10,dCGN
R11802 T13679 T13676 cc and,dCGN
R11803 T13592 T13589 appos ],bacteria
R11804 T13680 T13681 nummod 40,kDa
R11805 T13681 T13676 conj kDa,dCGN
R11806 T13682 T13681 punct ),kDa
R11807 T13593 T13592 punct ",",]
R11808 T13683 T13685 punct ",",observed
R11809 T13594 T13596 nmod [,]
R11810 T13684 T13685 nsubj we,observed
R11811 T13595 T13596 nummod 12,]
R11812 T13685 T13685 ROOT observed,observed
R11813 T13596 T13592 conj ],]
R11814 T13686 T13688 det a,correlation
R11815 T13687 T13688 amod strong,correlation
R11816 T13688 T13685 dobj correlation,observed
R11817 T13689 T13688 prep between,correlation
R11818 T13690 T13691 det the,severity
R11819 T13691 T13689 pobj severity,between
R11820 T13597 T13565 punct .,is
R11821 T13692 T13691 prep of,severity
R11822 T13693 T13694 det the,inflammation
R11823 T13598 T13607 advmod Thus,is
R11824 T13694 T13692 pobj inflammation,of
R11825 T13695 T13694 cc and,inflammation
R11826 T13696 T13699 det the,size
R11827 T13599 T13607 punct ",",is
R11828 T13697 T13699 nmod dCGN,size
R11829 T13698 T13699 amod molecular,size
R11830 T13699 T13694 conj size,inflammation
R11831 T13600 T13607 csubj understanding,is
R11832 T13700 T13685 punct ",",observed
R11833 T13701 T13702 advmod thus,confirming
R11834 T13601 T13602 det the,mechanisms
R11835 T13702 T13685 advcl confirming,observed
R11836 T13703 T13704 det the,size
R11837 T13704 T13706 nmod size,inflammation
R11838 T13602 T13600 dobj mechanisms,understanding
R11839 T13705 T13706 amod related,inflammation
R11840 T13706 T13702 dobj inflammation,confirming
R11841 T13603 T13602 prep of,mechanisms
R11842 T13707 T13706 prep in,inflammation
R11843 T13604 T13606 amod dCGN-induced,inflammation
R11844 T13708 T13707 pobj vivo,in
R11845 T13709 T13685 punct .,observed
R11846 T13710 T13712 det This,accumulation
R11847 T13605 T13606 compound bowel,inflammation
R11848 T13711 T13712 compound macrophage,accumulation
R11849 T13712 T13713 nsubj accumulation,was
R11850 T13713 T13713 ROOT was,was
R11851 T13606 T13603 pobj inflammation,of
R11852 T13714 T13713 neg not,was
R11853 T13607 T13607 ROOT is,is
R11854 T13608 T13607 prep of,is
R11855 T13609 T13610 amod great,importance
R11856 T13610 T13608 pobj importance,of
R11857 T13715 T13718 amod due,proliferation
R11858 T13716 T13717 aux to,cell
R11859 T13611 T13607 punct .,is
R11860 T13717 T13718 compound cell,proliferation
R11861 T13718 T13713 attr proliferation,was
R11862 T13612 T13618 prep In,analyzed
R11863 T13719 T13721 mark because,inhibited
R11864 T13720 T13721 nsubj dCGN,inhibited
R11865 T13613 T13614 det this,report
R11866 T13721 T13713 advcl inhibited,was
R11867 T13722 T13723 nummod THP-1,monocytes
R11868 T13723 T13724 compound monocytes,proliferation
R11869 T13724 T13721 dobj proliferation,inhibited
R11870 T13725 T13721 prep in,inhibited
R11871 T13614 T13612 pobj report,In
R11872 T13726 T13725 pobj vitro,in
R11873 T13727 T13713 punct .,was
R11874 T13728 T13729 det These,results
R11875 T13729 T13730 nsubj results,are
R11876 T13615 T13618 punct ",",analyzed
R11877 T13730 T13730 ROOT are,are
R11878 T13731 T13730 acomp similar,are
R11879 T13616 T13618 nsubj we,analyzed
R11880 T13732 T13731 prep to,similar
R11881 T13733 T13732 pobj those,to
R11882 T13617 T13618 aux have,analyzed
R11883 T13734 T13733 acl obtained,those
R11884 T13735 T13734 prep with,obtained
R11885 T13736 T13739 amod human,cells
R11886 T13812 T13790 punct .,detected
R11887 T13737 T13739 amod colonic,cells
R11888 T13738 T13739 amod epithelial,cells
R11889 T13739 T13735 pobj cells,with
R11890 T13813 T13814 det These,results
R11891 T13740 T13739 punct (,cells
R11892 T13741 T13743 nummod NCM460,line
R11893 T13742 T13743 compound cell,line
R11894 T13814 T13815 nsubj results,suggest
R11895 T13743 T13739 appos line,cells
R11896 T13744 T13739 punct ),cells
R11897 T13815 T13815 ROOT suggest,suggest
R11898 T13745 T13733 acl exposed,those
R11899 T13746 T13747 aux to,native
R11900 T13747 T13745 xcomp native,exposed
R11901 T13816 T13819 mark that,produce
R11902 T13748 T13747 dobj CGN,native
R11903 T13749 T13747 prep for,native
R11904 T13817 T13819 nsubj monocytes,produce
R11905 T13750 T13749 pobj 1,for
R11906 T13751 T13752 nummod 8,days
R11907 T13752 T13755 npadvmod days,]
R11908 T13818 T13819 aux might,produce
R11909 T13753 T13755 nmod [,]
R11910 T13754 T13755 nummod 37,]
R11911 T13819 T13815 ccomp produce,suggest
R11912 T13755 T13730 npadvmod ],are
R11913 T13756 T13730 punct .,are
R11914 T13757 T13760 advmod Thus,seems
R11915 T13820 T13819 dobj cytokines,produce
R11916 T13758 T13760 punct ",",seems
R11917 T13759 T13760 nsubj it,seems
R11918 T13760 T13760 ROOT seems,seems
R11919 T13761 T13763 mark that,promote
R11920 T13762 T13763 nsubj dCGN,promote
R11921 T13821 T13820 acl associated,cytokines
R11922 T13763 T13760 ccomp promote,seems
R11923 T13764 T13765 compound macrophage,infiltration
R11924 T13822 T13821 prep with,associated
R11925 T13765 T13763 dobj infiltration,promote
R11926 T13766 T13765 prep by,infiltration
R11927 T13767 T13766 pcomp recruiting,by
R11928 T13768 T13769 amod new,cells
R11929 T13823 T13822 pobj activation,with
R11930 T13769 T13767 dobj cells,recruiting
R11931 T13770 T13767 prep to,recruiting
R11932 T13771 T13774 det the,mucosa
R11933 T13824 T13823 prep into,activation
R11934 T13772 T13774 amod inflamed,mucosa
R11935 T13773 T13774 amod intestinal,mucosa
R11936 T13825 T13824 pobj macrophages,into
R11937 T13774 T13770 pobj mucosa,to
R11938 T13775 T13774 cc and,mucosa
R11939 T13826 T13821 prep in,associated
R11940 T13827 T13826 pobj response,in
R11941 T13776 T13766 neg not,by
R11942 T13777 T13763 prep by,promote
R11943 T13778 T13777 pcomp inducing,by
R11944 T13828 T13827 prep to,response
R11945 T13779 T13780 compound cell,proliferation
R11946 T13780 T13778 dobj proliferation,inducing
R11947 T13829 T13828 pobj dCGN,to
R11948 T13781 T13760 punct .,seems
R11949 T13782 T13790 prep In,detected
R11950 T13783 T13782 pobj addition,In
R11951 T13830 T13815 punct .,suggest
R11952 T13784 T13790 punct ",",detected
R11953 T13831 T13834 advmod Thus,analyzed
R11954 T13832 T13834 punct ",",analyzed
R11956 T13833 T13834 nsubj we,analyzed
R11958 T13834 T13834 ROOT analyzed,analyzed
R11959 T13787 T13788 compound polymorphonuclear,cells
R11960 T13835 T13836 det the,production
R11961 T13788 T13790 nsubjpass cells,detected
R11962 T13789 T13790 auxpass were,detected
R11963 T13836 T13834 dobj production,analyzed
R11964 T13790 T13790 ROOT detected,detected
R11965 T13791 T13790 prep in,detected
R11966 T13792 T13793 det the,mucosa
R11967 T13837 T13836 prep of,production
R11968 T13793 T13791 pobj mucosa,in
R11969 T13794 T13790 prep at,detected
R11970 T13795 T13797 det the,point
R11971 T13796 T13797 compound time,point
R11972 T13797 T13794 pobj point,at
R11973 T13838 T13837 pobj TNF,of
R11974 T13798 T13790 conj analyzed,detected
R11975 T13799 T13800 mark as,demonstrated
R11976 T13800 T13798 advcl demonstrated,analyzed
R11977 T13839 T13836 prep by,production
R11978 T13801 T13800 agent by,demonstrated
R11979 T13802 T13805 det a,level
R11980 T13840 T13841 preconj both,PBM
R11981 T13803 T13804 advmod very,low
R11982 T13804 T13805 amod low,level
R11983 T13841 T13844 nmod PBM,cells
R11984 T13805 T13801 pobj level,by
R11985 T13842 T13841 cc and,PBM
R11986 T13806 T13805 prep of,level
R11987 T13807 T13806 pobj MPO,of
R11988 T13843 T13841 conj THP-1,PBM
R11989 T13808 T13800 prep in,demonstrated
R11990 T13809 T13811 det the,tissue
R11991 T13810 T13811 amod intestinal,tissue
R11992 T13844 T13839 pobj cells,by
R11993 T13811 T13808 pobj tissue,in
R11994 T13845 T13834 prep in,analyzed
R11995 T13846 T13845 pobj response,in
R11996 T13847 T13846 prep to,response
R11997 T13909 T13910 advmod most,potent
R11998 T13848 T13847 pobj dCGN,to
R11999 T13910 T13911 amod potent,stimuli
R12000 T13911 T13907 pobj stimuli,among
R12001 T13912 T13911 prep for,stimuli
R12002 T13849 T13834 punct .,analyzed
R12003 T13913 T13914 compound leukocyte,activation
R12004 T13914 T13912 pobj activation,for
R12005 T13915 T13891 punct .,was
R12006 T13850 T13851 amod Degraded,CGN
R12007 T13916 T13917 det These,results
R12008 T13917 T13918 nsubj results,underline
R12009 T13918 T13918 ROOT underline,underline
R12010 T13851 T13852 nsubj CGN,induced
R12011 T13919 T13920 det the,fact
R12012 T13920 T13918 dobj fact,underline
R12013 T13852 T13852 ROOT induced,induced
R12014 T13921 T13927 mark that,have
R12015 T13922 T13924 det partially,forms
R12016 T13923 T13924 amod degraded,forms
R12017 T13853 T13855 det a,production
R12018 T13924 T13927 nsubj forms,have
R12019 T13925 T13924 prep of,forms
R12020 T13926 T13925 pobj CGN,of
R12021 T13854 T13855 amod robust,production
R12022 T13927 T13920 acl have,fact
R12023 T13928 T13930 amod important,effects
R12024 T13929 T13930 amod cellular,effects
R12025 T13855 T13852 dobj production,induced
R12026 T13930 T13927 dobj effects,have
R12027 T13931 T13918 punct .,underline
R12028 T13856 T13855 prep of,production
R12029 T13932 T13933 det The,amount
R12030 T13933 T13939 nsubj amount,induced
R12031 T13934 T13933 prep of,amount
R12032 T13857 T13856 pobj TNF,of
R12033 T13935 T13934 pobj TNF,of
R12034 T13936 T13933 acl secreted,amount
R12035 T13858 T13855 prep by,production
R12036 T13937 T13936 agent by,secreted
R12037 T13938 T13937 pobj PBM,by
R12038 T13859 T13858 pobj monocytes,by
R12039 T13939 T13939 ROOT induced,induced
R12040 T13940 T13939 prep with,induced
R12041 T13941 T13940 pobj LPS,with
R12042 T13860 T13852 punct .,induced
R12043 T13942 T13939 conj was,induced
R12044 T13943 T13944 advmod much,larger
R12045 T13944 T13942 acomp larger,was
R12046 T13861 T13864 det The,form
R12047 T13945 T13944 prep than,larger
R12048 T13946 T13947 det the,one
R12049 T13947 T13945 pobj one,than
R12050 T13862 T13864 nummod 40,form
R12051 T13948 T13947 acl secreted,one
R12052 T13949 T13948 agent by,secreted
R12053 T13863 T13864 compound kDa,form
R12054 T13950 T13951 nummod THP-1,monocytes
R12055 T13951 T13949 pobj monocytes,by
R12056 T13952 T13939 punct .,induced
R12057 T13864 T13867 nsubj form,was
R12058 T13953 T13959 prep Since,associated
R12059 T13954 T13955 compound monocyte,activation
R12060 T13955 T13953 pobj activation,Since
R12061 T13865 T13864 prep of,form
R12062 T13956 T13955 prep by,activation
R12063 T13957 T13956 pobj LPS,by
R12064 T13866 T13865 pobj dCGN,of
R12065 T13958 T13959 auxpass is,associated
R12066 T13959 T13959 ROOT associated,associated
R12067 T13960 T13959 prep with,associated
R12068 T13867 T13867 ROOT was,was
R12069 T13961 T13962 det the,presence
R12070 T13962 T13960 pobj presence,with
R12071 T13868 T13869 advmod more,potent
R12072 T13963 T13962 prep of,presence
R12073 T13964 T13965 det the,CD14
R12074 T13965 T13968 nmod CD14,receptors
R12075 T13869 T13867 acomp potent,was
R12076 T13966 T13965 cc and,CD14
R12077 T13967 T13965 conj TLR4,CD14
R12078 T13968 T13963 pobj receptors,of
R12079 T13870 T13869 prep for,potent
R12080 T13969 T13971 nmod [,]
R12081 T13970 T13971 nummod 38,]
R12082 T13871 T13872 compound monocyte,stimulation
R12083 T13971 T13968 appos ],receptors
R12084 T13972 T13974 nmod [,]
R12085 T13973 T13974 nummod 40,]
R12086 T13872 T13870 pobj stimulation,for
R12087 T13974 T13971 appos ],]
R12088 T13975 T13979 punct ",",observed
R12089 T13873 T13869 prep than,potent
R12090 T13976 T13978 det the,response
R12091 T13977 T13978 amod different,response
R12092 T13978 T13979 nsubj response,observed
R12093 T13979 T13981 parataxis observed,be
R12094 T13874 T13876 det the,kDa
R12095 T13980 T13981 aux could,be
R12096 T13981 T13959 advcl be,associated
R12097 T13982 T13981 acomp due,be
R12098 T13875 T13876 nummod 10,kDa
R12099 T13983 T13982 pcomp to,due
R12100 T13984 T13986 det the,expression
R12101 T13985 T13986 amod different,expression
R12102 T13876 T13873 pobj kDa,than
R12103 T13986 T13983 pobj expression,to
R12104 T13987 T13986 prep of,expression
R12105 T13877 T13876 cc or,kDa
R12106 T13988 T13989 det these,receptors
R12107 T13989 T13987 pobj receptors,of
R12108 T13990 T13986 prep in,expression
R12109 T13878 T13880 det the,ones
R12110 T13991 T13994 nmod PBM,cells
R12111 T13992 T13991 cc and,PBM
R12112 T13993 T13991 conj THP-1,PBM
R12113 T13879 T13880 amod native,ones
R12114 T13994 T13990 pobj cells,in
R12115 T13995 T13959 punct .,associated
R12116 T13996 T13999 nsubjpass CD14,expressed
R12117 T13880 T13876 conj ones,kDa
R12118 T13997 T13999 auxpass is,expressed
R12119 T13998 T13999 neg not,expressed
R12120 T13999 T13999 ROOT expressed,expressed
R12121 T14000 T13999 agent by,expressed
R12122 T14001 T14002 nummod THP-1,monocytes
R12123 T13881 T13867 punct .,was
R12124 T14002 T14000 pobj monocytes,by
R12125 T14003 T13999 punct ",",expressed
R12126 T13882 T13891 advmod Surprisingly,was
R12127 T13883 T13891 punct ",",was
R12128 T14004 T13999 cc but,expressed
R12129 T14005 T14007 nsubjpass it,expressed
R12130 T13884 T13885 compound monocyte,activation
R12131 T13885 T13891 nsubj activation,was
R12132 T13886 T13885 prep by,activation
R12133 T14006 T14007 auxpass is,expressed
R12134 T14007 T13999 conj expressed,expressed
R12135 T13887 T13886 pobj dCGN,by
R12136 T14008 T14007 agent by,expressed
R12137 T14009 T14008 pobj PBM,by
R12138 T13888 T13889 aux to,produce
R12139 T14010 T14007 punct .,expressed
R12140 T14011 T14012 det This,fact
R12141 T13889 T13885 acl produce,activation
R12142 T14012 T14014 nsubj fact,explain
R12143 T13890 T13889 dobj TNF,produce
R12144 T13891 T13891 ROOT was,was
R12145 T14013 T14014 aux could,explain
R12146 T13892 T13893 advmod much,stronger
R12147 T13893 T13891 acomp stronger,was
R12148 T14014 T14014 ROOT explain,explain
R12149 T14015 T14018 advmod why,produced
R12150 T13894 T13893 prep than,stronger
R12151 T14016 T14017 amod THP-1,cells
R12152 T14017 T14018 nsubj cells,produced
R12153 T14018 T14014 ccomp produced,explain
R12154 T13895 T13896 det the,activation
R12155 T14019 T14022 det a,response
R12156 T14020 T14021 advmod much,smaller
R12157 T14021 T14022 amod smaller,response
R12158 T13896 T13894 pobj activation,than
R12159 T14022 T14018 dobj response,produced
R12160 T14023 T14022 prep to,response
R12161 T14024 T14023 pobj LPS,to
R12162 T13897 T13896 acl induced,activation
R12163 T14025 T14022 prep than,response
R12164 T14026 T14025 pobj PBM,than
R12165 T13898 T13897 agent by,induced
R12166 T14027 T14018 cc and,produced
R12167 T14028 T14030 advmod also,difference
R12168 T14029 T14030 det the,difference
R12169 T13899 T13898 pobj LPS,by
R12170 T14030 T14036 nsubj difference,induced
R12171 T14031 T14030 prep of,difference
R12172 T14032 T14031 pobj kinetics,of
R12173 T14033 T14032 prep in,kinetics
R12174 T14034 T14035 det the,LPS
R12175 T14035 T14033 pobj LPS,in
R12176 T13900 T13899 punct ",",LPS
R12177 T14036 T14014 conj induced,explain
R12178 T14037 T14038 compound TNF,secretion
R12179 T14038 T14036 dobj secretion,induced
R12180 T13901 T13903 det an,factor
R12181 T14039 T14036 punct .,induced
R12182 T14040 T14041 det The,peak
R12183 T14041 T14046 nsubjpass peak,observed
R12184 T13902 T13903 amod inflammatory,factor
R12185 T13903 T13899 appos factor,LPS
R12186 T14042 T14041 prep of,peak
R12187 T13904 T13903 acl considered,factor
R12188 T14043 T14044 compound TNF,response
R12189 T14044 T14042 pobj response,of
R12190 T14045 T14046 auxpass was,observed
R12191 T13905 T13906 aux to,be
R12192 T14046 T14046 ROOT observed,observed
R12193 T14047 T14046 prep after,observed
R12194 T13906 T13904 xcomp be,considered
R12195 T14048 T14050 nummod 8,stimulation
R12196 T14049 T14050 compound h,stimulation
R12197 T14050 T14047 pobj stimulation,after
R12198 T13907 T13906 prep among,be
R12199 T14051 T14050 acl followed,stimulation
R12200 T13908 T13911 det the,stimuli
R12201 T14052 T14051 agent by,followed
R12202 T14053 T14055 det a,decrease
R12203 T14054 T14055 amod rapid,decrease
R12204 T14072 T14071 prep after,until
R12205 T14055 T14052 pobj decrease,by
R12206 T14056 T14055 prep to,decrease
R12207 T14057 T14056 pobj baseline,to
R12208 T14058 T14055 prep at,decrease
R12209 T14059 T14060 nummod 10,h
R12210 T14073 T14074 nummod 56,h.
R12211 T14060 T14058 pobj h,at
R12212 T14061 T14046 punct ",",observed
R12213 T14062 T14070 mark whereas,reached
R12214 T14074 T14072 pobj h.,after
R12215 T14063 T14070 prep on,reached
R12216 T14064 T14065 nummod THP-1,cells
R12217 T14065 T14063 pobj cells,on
R12218 T14075 T14087 advmod Moreover,was
R12219 T14066 T14067 det the,peak
R12220 T14067 T14070 nsubjpass peak,reached
R12221 T14068 T14070 auxpass was,reached
R12222 T14069 T14070 neg not,reached
R12223 T14070 T14046 advcl reached,observed
R12224 T14076 T14087 punct ",",was
R12225 T14071 T14070 prep until,reached
R12226 T14077 T14078 det the,amount
R12227 T14078 T14087 nsubj amount,was
R12228 T14079 T14078 prep of,amount
R12229 T14103 T14102 cc and,LPS
R12230 T14080 T14079 pobj TNF,of
R12231 T14104 T14102 conj dCGN,LPS
R12232 T14105 T14105 ROOT displayed,displayed
R12233 T14106 T14111 det a,curve
R12234 T14081 T14078 acl secreted,amount
R12235 T14107 T14108 advmod very,different
R12236 T14108 T14111 amod different,curve
R12237 T14109 T14111 compound TNF,curve
R12238 T14082 T14081 agent by,secreted
R12239 T14110 T14111 compound secretion,curve
R12240 T14111 T14105 dobj curve,displayed
R12241 T14083 T14082 pobj monocytes,by
R12242 T14112 T14111 prep in,curve
R12243 T14113 T14114 nummod THP-1,cells
R12244 T14114 T14112 pobj cells,in
R12245 T14084 T14083 acl induced,monocytes
R12246 T14115 T14105 punct .,displayed
R12247 T14116 T14117 det These,differences
R12248 T14085 T14084 prep with,induced
R12249 T14117 T14118 nsubj differences,suggest
R12250 T14118 T14118 ROOT suggest,suggest
R12251 T14119 T14124 mark that,use
R12252 T14086 T14085 pobj dCGN,with
R12253 T14120 T14124 nsubj dCGN,use
R12254 T14087 T14087 ROOT was,was
R12255 T14088 T14089 advmod much,larger
R12256 T14121 T14120 cc and,dCGN
R12257 T14122 T14120 conj LPS,dCGN
R12258 T14089 T14087 acomp larger,was
R12259 T14090 T14089 prep than,larger
R12260 T14123 T14124 aux could,use
R12261 T14091 T14092 det the,one
R12262 T14124 T14118 ccomp use,suggest
R12263 T14125 T14127 amod different,mechanisms
R12264 T14126 T14127 compound activation,mechanisms
R12265 T14092 T14090 pobj one,than
R12266 T14127 T14124 dobj mechanisms,use
R12267 T14128 T14118 punct .,suggest
R12268 T14129 T14130 nsubj It,is
R12269 T14093 T14092 acl induced,one
R12270 T14130 T14130 ROOT is,is
R12271 T14131 T14130 acomp noteworthy,is
R12272 T14132 T14144 mark that,inhibited
R12273 T14133 T14144 csubj neutralizing,inhibited
R12274 T14094 T14093 agent by,induced
R12275 T14134 T14133 dobj antibody,neutralizing
R12276 T14135 T14133 prep to,neutralizing
R12277 T14136 T14135 pobj CD14,to
R12278 T14137 T14138 advmod only,partially
R12279 T14095 T14094 pobj LPS,by
R12280 T14138 T14144 advmod partially,inhibited
R12281 T14139 T14142 punct (,%
R12282 T14140 T14142 nmod <,%
R12283 T14096 T14087 punct .,was
R12284 T14141 T14142 nummod 40,%
R12285 T14142 T14138 appos %,partially
R12286 T14143 T14138 punct ),partially
R12287 T14097 T14105 prep On,displayed
R12288 T14144 T14130 ccomp inhibited,is
R12289 T14145 T14147 amod dCGN-induced,secretion
R12290 T14146 T14147 compound TNF,secretion
R12291 T14098 T14100 det the,hand
R12292 T14147 T14144 dobj secretion,inhibited
R12293 T14148 T14150 punct (,shown
R12294 T14099 T14100 amod other,hand
R12295 T14149 T14150 neg not,shown
R12296 T14150 T14147 parataxis shown,secretion
R12297 T14151 T14150 punct ),shown
R12298 T14100 T14097 pobj hand,On
R12299 T14152 T14130 punct .,is
R12300 T14153 T14157 nsubjpass TLR4,identified
R12301 T14154 T14157 aux has,identified
R12302 T14101 T14105 punct ",",displayed
R12303 T14155 T14157 auxpass been,identified
R12304 T14156 T14157 advmod recently,identified
R12305 T14157 T14157 ROOT identified,identified
R12306 T14102 T14105 nsubj LPS,displayed
R12307 T14158 T14157 prep as,identified
R12308 T14169 T14165 pobj cells,in
R12309 T14159 T14162 det a,receptor
R12310 T14160 T14162 compound surface,receptor
R12311 T14161 T14162 compound membrane,receptor
R12312 T14162 T14158 pobj receptor,as
R12313 T14163 T14162 prep for,receptor
R12314 T14164 T14163 pobj CGN,for
R12315 T14170 T14172 nmod [,]
R12316 T14165 T14162 prep in,receptor
R12317 T14166 T14169 amod human,cells
R12318 T14167 T14169 amod colonic,cells
R12319 T14171 T14172 nummod 41,]
R12320 T14168 T14169 amod epithelial,cells
R12321 T14172 T14162 conj ],receptor
R12322 T14173 T14157 punct .,identified
R12323 T14174 T14177 advmod Thus,is
R12324 T14200 T14203 det a,site
R12325 T14175 T14177 punct ",",is
R12326 T14201 T14203 amod higher,site
R12327 T14202 T14203 amod affinity-binding,site
R12328 T14176 T14177 nsubj it,is
R12329 T14203 T14199 dobj site,have
R12330 T14204 T14203 prep for,site
R12331 T14177 T14177 ROOT is,is
R12332 T14178 T14177 acomp possible,is
R12334 T14179 T14182 mark that,activated
R12338 T14180 T14182 nsubjpass TLR4,activated
R12339 T14181 T14182 auxpass is,activated
R12341 T14182 T14177 ccomp activated,is
R12344 T14183 T14182 agent by,activated
R12346 T14213 T14214 nsubj hypothesis,remains
R12347 T14184 T14183 pobj dCGN,by
R12348 T14214 T14195 conj remains,speculate
R12349 T14215 T14217 aux to,tested
R12350 T14185 T14186 aux to,induce
R12351 T14216 T14217 auxpass be,tested
R12352 T14217 T14214 xcomp tested,remains
R12353 T14218 T14214 punct .,remains
R12354 T14186 T14182 advcl induce,activated
R12355 T14219 T14220 det Another,indicator
R12356 T14220 T14231 nsubj indicator,is
R12357 T14187 T14188 amod cytokine,secretion
R12358 T14221 T14223 mark that,stimulate
R12359 T14222 T14223 nsubj dCGN,stimulate
R12360 T14223 T14220 acl stimulate,indicator
R12361 T14188 T14186 dobj secretion,induce
R12362 T14224 T14223 dobj monocytes,stimulate
R12363 T14225 T14223 advcl leading,stimulate
R12364 T14189 T14186 prep by,induce
R12365 T14226 T14225 prep to,leading
R12366 T14227 T14230 det a,phenotype
R12367 T14190 T14189 pobj monocytes,by
R12368 T14228 T14229 advmod more,active
R12369 T14229 T14230 amod active,phenotype
R12370 T14230 T14226 pobj phenotype,to
R12371 T14191 T14177 punct .,is
R12372 T14231 T14231 ROOT is,is
R12373 T14232 T14233 det the,fact
R12374 T14233 T14231 attr fact,is
R12375 T14234 T14243 mark that,enhanced
R12376 T14235 T14236 compound surface,expression
R12377 T14236 T14243 nsubjpass expression,enhanced
R12378 T14192 T14195 nsubj We,speculate
R12379 T14237 T14236 prep of,expression
R12380 T14238 T14241 det the,ICAM-1
R12381 T14239 T14240 compound adhesion,molecule
R12382 T14193 T14195 aux can,speculate
R12383 T14240 T14241 compound molecule,ICAM-1
R12384 T14241 T14237 pobj ICAM-1,of
R12385 T14242 T14243 auxpass was,enhanced
R12386 T14194 T14195 advmod only,speculate
R12387 T14243 T14233 acl enhanced,fact
R12388 T14244 T14243 prep in,enhanced
R12389 T14245 T14246 preconj both,PBM
R12390 T14195 T14195 ROOT speculate,speculate
R12391 T14246 T14249 nmod PBM,cells
R12392 T14247 T14246 cc and,PBM
R12393 T14196 T14199 mark that,have
R12394 T14248 T14246 conj THP-1,PBM
R12395 T14249 T14244 pobj cells,in
R12396 T14250 T14231 punct .,is
R12397 T14197 T14199 nsubj TLR4,have
R12398 T14251 T14256 det The,caused
R12399 T14252 T14256 prep over,caused
R12400 T14253 T14252 pobj expression,over
R12401 T14198 T14199 aux may,have
R12402 T14254 T14253 prep of,expression
R12403 T14255 T14254 pobj ICAM-1,of
R12404 T14199 T14195 ccomp have,speculate
R12405 T14256 T14256 ROOT caused,caused
R12406 T14257 T14259 det the,monocytes
R12407 T14297 T14298 nsubj CGN,is
R12408 T14258 T14259 amod activated,monocytes
R12409 T14259 T14261 nsubj monocytes,form
R12410 T14260 T14261 aux to,form
R12411 T14261 T14256 ccomp form,caused
R12412 T14262 T14263 compound cell,aggregates
R12413 T14298 T14292 ccomp is,suggesting
R12414 T14263 T14261 dobj aggregates,form
R12415 T14264 T14265 nsubj that,were
R12416 T14265 T14263 relcl were,aggregates
R12417 T14299 T14300 advmod more,biologically
R12418 T14266 T14267 advmod more,abundant
R12419 T14267 T14265 acomp abundant,were
R12420 T14300 T14301 advmod biologically,active
R12421 T14268 T14265 prep among,were
R12422 T14269 T14268 pobj cells,among
R12423 T14270 T14269 acl treated,cells
R12424 T14271 T14270 prep with,treated
R12425 T14272 T14275 det the,dCGN
R12426 T14273 T14275 nummod 40,dCGN
R12427 T14274 T14275 compound kDa,dCGN
R12428 T14301 T14298 acomp active,is
R12429 T14275 T14271 pobj dCGN,with
R12430 T14276 T14256 punct .,caused
R12431 T14277 T14278 nsubj This,correlates
R12432 T14302 T14278 punct .,correlates
R12433 T14278 T14278 ROOT correlates,correlates
R12434 T14303 T14309 prep In,are
R12435 T14279 T14278 prep with,correlates
R12436 T14280 T14282 det the,expression
R12437 T14304 T14303 pobj addition,In
R12438 T14281 T14282 amod higher,expression
R12439 T14282 T14279 pobj expression,with
R12440 T14283 T14282 prep of,expression
R12441 T14305 T14309 punct ",",are
R12442 T14284 T14283 pobj ICAM-1,of
R12443 T14285 T14282 acl induced,expression
R12444 T14286 T14285 agent by,induced
R12445 T14306 T14308 det the,aggregates
R12446 T14287 T14290 det the,dCGN
R12447 T14288 T14290 nummod 40,dCGN
R12448 T14289 T14290 compound kDa,dCGN
R12449 T14307 T14308 compound cell,aggregates
R12450 T14290 T14286 pobj dCGN,by
R12451 T14291 T14278 punct ",",correlates
R12452 T14292 T14278 advcl suggesting,correlates
R12453 T14308 T14309 nsubj aggregates,are
R12454 T14293 T14298 mark that,is
R12455 T14294 T14297 det the,CGN
R12456 T14295 T14296 advmod partially,degraded
R12457 T14309 T14309 ROOT are,are
R12458 T14296 T14297 amod degraded,CGN
R12459 T14310 T14309 acomp reminiscent,are
R12460 T14311 T14310 prep of,reminiscent
R12461 T14312 T14313 compound monocyte,aggregates
R12462 T14313 T14311 pobj aggregates,of
R12463 T14394 T14395 amod increased,number
R12464 T14395 T14392 dobj number,express
R12465 T14314 T14313 punct ",",aggregates
R12466 T14396 T14395 prep of,number
R12467 T14397 T14399 compound ICAM-1,molecules
R12468 T14398 T14399 compound adhesion,molecules
R12469 T14315 T14316 nsubj which,form
R12470 T14399 T14396 pobj molecules,of
R12471 T14400 T14389 punct ",",activate
R12472 T14316 T14313 relcl form,aggregates
R12473 T14401 T14402 advmod therefore,being
R12474 T14317 T14318 compound multinucleated,giant
R12475 T14402 T14389 advcl being,activate
R12476 T14403 T14402 acomp capable,being
R12477 T14404 T14403 prep of,capable
R12478 T14318 T14319 amod giant,cells
R12479 T14405 T14404 pcomp creating,of
R12480 T14406 T14408 det the,characteristic
R12481 T14407 T14408 compound conditions,characteristic
R12482 T14319 T14316 dobj cells,form
R12483 T14408 T14405 dobj characteristic,creating
R12484 T14409 T14408 prep of,characteristic
R12485 T14320 T14321 punct (,MGC
R12486 T14410 T14413 poss Crohn,symptomatology
R12487 T14411 T14410 case 's,Crohn
R12488 T14321 T14319 appos MGC,cells
R12489 T14412 T14413 compound disease,symptomatology
R12490 T14413 T14409 pobj symptomatology,of
R12491 T14414 T14413 punct ",",symptomatology
R12492 T14415 T14417 advmod i.e.,accumulation
R12493 T14322 T14313 punct ),aggregates
R12494 T14416 T14417 nmod PBM,accumulation
R12495 T14417 T14413 appos accumulation,symptomatology
R12496 T14323 T14309 prep in,are
R12497 T14418 T14417 cc and,accumulation
R12498 T14419 T14420 compound MGC,formation
R12499 T14420 T14421 compound formation,[
R12500 T14324 T14323 pobj patients,in
R12501 T14421 T14417 conj [,accumulation
R12502 T14422 T14423 nummod 45,]
R12503 T14423 T14423 ROOT ],]
R12504 T14325 T14309 prep with,are
R12505 T14424 T14423 punct ",",]
R12506 T14425 T14427 nmod [,]
R12507 T14426 T14427 nummod 46,]
R12508 T14326 T14328 poss Crohn,disease
R12509 T14427 T14423 appos ],]
R12510 T14428 T14389 punct .,activate
R12511 T14429 T14431 det The,pathway
R12512 T14327 T14326 case 's,Crohn
R12513 T14430 T14431 amod NF-κB,pathway
R12514 T14431 T14432 nsubj pathway,regulates
R12515 T14432 T14432 ROOT regulates,regulates
R12516 T14328 T14325 pobj disease,with
R12517 T14433 T14432 dobj genes,regulates
R12518 T14329 T14328 appos [,disease
R12519 T14330 T14331 nummod 42,]
R12520 T14434 T14433 amod responsible,genes
R12521 T14435 T14434 prep for,responsible
R12522 T14436 T14435 pobj ICAM-1,for
R12523 T14437 T14436 cc and,ICAM-1
R12524 T14331 T14329 appos ],[
R12525 T14438 T14439 compound TNF-α,expression
R12526 T14439 T14436 conj expression,ICAM-1
R12527 T14440 T14432 punct .,regulates
R12528 T14441 T14442 amod NF-κB,activation
R12529 T14332 T14309 punct .,are
R12530 T14442 T14444 nsubjpass activation,associated
R12531 T14443 T14444 auxpass is,associated
R12532 T14333 T14335 det These,cells
R12533 T14444 T14444 ROOT associated,associated
R12534 T14445 T14444 prep with,associated
R12535 T14446 T14447 det the,degradation
R12536 T14334 T14335 amod giant,cells
R12537 T14447 T14445 pobj degradation,with
R12538 T14448 T14447 prep of,degradation
R12539 T14449 T14451 det the,protein
R12540 T14335 T14338 nsubjpass cells,observed
R12541 T14450 T14451 compound inhibitor,protein
R12542 T14451 T14448 pobj protein,of
R12543 T14452 T14453 compound IκB,[
R12544 T14336 T14338 auxpass were,observed
R12545 T14453 T14447 appos [,degradation
R12546 T14454 T14455 nummod 47,]
R12547 T14455 T14453 appos ],[
R12548 T14337 T14338 neg not,observed
R12549 T14456 T14444 punct .,associated
R12550 T14457 T14460 advmod Indeed,induced
R12551 T14458 T14460 punct ",",induced
R12552 T14338 T14338 ROOT observed,observed
R12553 T14459 T14460 nsubj dCGN,induced
R12554 T14460 T14460 ROOT induced,induced
R12555 T14461 T14462 compound NF-κB,activation
R12556 T14339 T14338 prep in,observed
R12557 T14462 T14460 dobj activation,induced
R12558 T14463 T14464 mark as,shown
R12559 T14464 T14460 advcl shown,induced
R12560 T14340 T14341 amod healthy,individuals
R12561 T14465 T14464 agent by,shown
R12562 T14466 T14465 pobj degradation,by
R12563 T14341 T14339 pobj individuals,in
R12564 T14467 T14466 prep of,degradation
R12565 T14468 T14467 pobj IκBα,of
R12566 T14469 T14468 punct ",",IκBα
R12567 T14342 T14339 cc or,in
R12568 T14470 T14468 appos translocation,IκBα
R12569 T14471 T14470 prep of,translocation
R12570 T14343 T14339 conj in,in
R12571 T14472 T14471 pobj p65,of
R12572 T14473 T14472 cc and,p65
R12573 T14474 T14472 conj p50,p65
R12574 T14475 T14471 pobj sub-units,of
R12575 T14476 T14460 prep to,induced
R12576 T14477 T14478 det the,nucleus
R12577 T14344 T14343 pobj patients,in
R12578 T14478 T14476 pobj nucleus,to
R12579 T14479 T14460 cc and,induced
R12580 T14345 T14344 prep with,patients
R12581 T14480 T14460 agent by,induced
R12582 T14481 T14480 pobj activation,by
R12583 T14346 T14347 amod ulcerative,colitis
R12584 T14347 T14345 pobj colitis,with
R12585 T14482 T14481 prep of,activation
R12586 T14483 T14487 det an,plasmid
R12587 T14484 T14487 amod NF-κB-responsive,plasmid
R12588 T14348 T14350 nmod [,]
R12589 T14485 T14487 compound luciferase,plasmid
R12590 T14486 T14487 compound reporter,plasmid
R12591 T14487 T14482 pobj plasmid,of
R12592 T14349 T14350 nummod 42,]
R12593 T14488 T14460 punct .,induced
R12594 T14489 T14497 advmod Again,induced
R12595 T14350 T14350 ROOT ],]
R12596 T14490 T14497 punct ",",induced
R12597 T14351 T14338 punct .,observed
R12598 T14352 T14366 advmod Moreover,detected
R12599 T14353 T14354 punct ",",increased
R12600 T14354 T14366 nsubjpass increased,detected
R12601 T14491 T14493 det a,activation
R12602 T14355 T14356 compound expression,levels
R12603 T14492 T14493 amod stronger,activation
R12604 T14493 T14497 nsubjpass activation,induced
R12605 T14494 T14493 prep of,activation
R12606 T14356 T14354 dobj levels,increased
R12607 T14495 T14494 pobj NF-κB,of
R12608 T14496 T14497 auxpass was,induced
R12609 T14357 T14356 prep of,levels
R12610 T14497 T14497 ROOT induced,induced
R12611 T14498 T14497 agent by,induced
R12612 T14499 T14502 det the,dCGN
R12613 T14358 T14357 pobj ICAM-1,of
R12614 T14500 T14502 nummod 40,dCGN
R12615 T14501 T14502 compound kDa,dCGN
R12616 T14359 T14358 cc and,ICAM-1
R12617 T14502 T14498 pobj dCGN,by
R12618 T14503 T14497 prep compared,induced
R12619 T14504 T14503 prep to,compared
R12620 T14360 T14358 conj LFA-3,ICAM-1
R12621 T14505 T14507 nummod 10,dCGN
R12622 T14506 T14507 compound kDa,dCGN
R12623 T14507 T14504 pobj dCGN,to
R12624 T14508 T14497 punct ",",induced
R12625 T14509 T14497 advcl suggesting,induced
R12626 T14510 T14515 mark that,is
R12627 T14361 T14362 punct (,CD58
R12628 T14511 T14514 det the,CGN
R12629 T14362 T14360 appos CD58,LFA-3
R12630 T14363 T14360 punct ),LFA-3
R12631 T14512 T14513 advmod partially,degraded
R12632 T14513 T14514 amod degraded,CGN
R12633 T14364 T14366 auxpass were,detected
R12634 T14514 T14515 nsubj CGN,is
R12635 T14515 T14509 ccomp is,suggesting
R12636 T14516 T14517 advmod more,biologically
R12637 T14365 T14366 advmod also,detected
R12638 T14517 T14518 advmod biologically,active
R12639 T14518 T14515 acomp active,is
R12640 T14366 T14366 ROOT detected,detected
R12641 T14519 T14497 punct .,induced
R12642 T14520 T14521 poss Our,data
R12643 T14521 T14522 nsubj data,are
R12644 T14522 T14522 ROOT are,are
R12645 T14367 T14366 prep in,detected
R12646 T14523 T14522 prep in,are
R12647 T14524 T14523 pobj agreement,in
R12648 T14368 T14367 pobj monocytes,in
R12649 T14525 T14524 prep with,agreement
R12650 T14526 T14528 det a,study
R12651 T14527 T14528 amod previous,study
R12652 T14369 T14366 prep from,detected
R12653 T14528 T14525 pobj study,with
R12654 T14529 T14528 acl showing,study
R12655 T14370 T14369 pobj patients,from
R12656 T14530 T14534 mark that,induced
R12657 T14531 T14532 amod native,CGN
R12658 T14532 T14534 nsubj CGN,induced
R12659 T14371 T14366 prep with,detected
R12660 T14533 T14534 advmod also,induced
R12661 T14534 T14529 ccomp induced,showing
R12662 T14535 T14534 dobj activation,induced
R12663 T14372 T14374 poss Crohn,disease
R12664 T14536 T14535 prep of,activation
R12665 T14537 T14536 pobj NF-κB,of
R12666 T14373 T14372 case 's,Crohn
R12667 T14538 T14535 prep in,activation
R12668 T14539 T14542 amod human,cells
R12669 T14540 T14542 amod colonic,cells
R12670 T14374 T14371 pobj disease,with
R12671 T14541 T14542 amod epithelial,cells
R12672 T14542 T14538 pobj cells,in
R12673 T14543 T14545 nmod [,]
R12674 T14544 T14545 nummod 48,]
R12675 T14545 T14534 dobj ],induced
R12676 T14546 T14522 punct .,are
R12677 T14547 T14548 amod NF-κB,pathway
R12678 T14375 T14377 nmod [,]
R12679 T14548 T14551 nsubjpass pathway,associated
R12680 T14549 T14551 auxpass is,associated
R12681 T14550 T14551 advmod often,associated
R12682 T14376 T14377 nummod 43,]
R12683 T14551 T14551 ROOT associated,associated
R12684 T14552 T14553 aux to,promote
R12685 T14553 T14551 xcomp promote,associated
R12686 T14377 T14374 appos ],disease
R12687 T14554 T14555 compound cell,survival
R12688 T14555 T14553 dobj survival,promote
R12689 T14378 T14377 punct ",",]
R12690 T14556 T14555 cc and,survival
R12691 T14557 T14558 compound cancer,cell
R12692 T14558 T14559 compound cell,growth
R12693 T14379 T14381 nmod [,]
R12694 T14559 T14555 conj growth,survival
R12695 T14560 T14566 punct ",",reported
R12696 T14561 T14566 advmod however,reported
R12697 T14380 T14381 nummod 44,]
R12698 T14562 T14566 nsubjpass it,reported
R12699 T14563 T14566 aux has,reported
R12700 T14381 T14377 appos ],]
R12701 T14564 T14566 auxpass been,reported
R12702 T14565 T14566 advmod sometimes,reported
R12703 T14566 T14551 conj reported,associated
R12704 T14382 T14366 punct .,detected
R12705 T14567 T14568 aux to,behave
R12706 T14568 T14566 xcomp behave,reported
R12707 T14383 T14389 advmod Thus,activate
R12708 T14384 T14389 punct ",",activate
R12709 T14569 T14568 prep as,behave
R12710 T14570 T14572 det a,suppressor
R12711 T14385 T14386 amod degraded,CGN
R12712 T14571 T14572 compound tumor,suppressor
R12713 T14572 T14569 pobj suppressor,as
R12714 T14386 T14389 nsubj CGN,activate
R12715 T14387 T14389 advmod clearly,activate
R12717 T14388 T14389 aux can,activate
R12720 T14389 T14389 ROOT activate,activate
R12726 T14390 T14389 dobj monocytes,activate
R12730 T14391 T14392 aux to,express
R12733 T14392 T14389 advcl express,activate
R12736 T14393 T14395 det an,number
R12737 T14685 T14687 det an,phenotype
R12740 T14686 T14687 amod inflammatory,phenotype
R12741 T14590 T14592 aux has,reported
R12742 T14591 T14592 auxpass been,reported
R12743 T14687 T14684 dobj phenotype,acquired
R12744 T14592 T14592 ROOT reported,reported
R12745 T14593 T14592 prep in,reported
R12746 T14688 T14689 nsubj that,included
R12747 T14689 T14687 relcl included,phenotype
R12748 T14594 T14597 amod normal,cells
R12749 T14595 T14597 amod human,cells
R12750 T14690 T14691 amod higher,expression
R12751 T14596 T14597 amod epidermal,cells
R12752 T14597 T14593 pobj cells,in
R12753 T14691 T14689 dobj expression,included
R12754 T14598 T14600 nmod [,]
R12755 T14599 T14600 nummod 50,]
R12756 T14600 T14592 npadvmod ],reported
R12757 T14692 T14691 prep of,expression
R12758 T14601 T14592 punct .,reported
R12759 T14602 T14607 advmod Indeed,shown
R12760 T14693 T14696 det the,ICAM-1
R12761 T14603 T14607 punct ",",shown
R12762 T14604 T14607 nsubjpass it,shown
R12763 T14605 T14607 aux has,shown
R12764 T14694 T14695 compound adhesion,molecule
R12765 T14606 T14607 auxpass been,shown
R12766 T14607 T14607 ROOT shown,shown
R12767 T14608 T14611 mark that,suppressed
R12768 T14695 T14696 compound molecule,ICAM-1
R12769 T14609 T14610 amod NF-κB,activation
R12770 T14610 T14611 nsubj activation,suppressed
R12771 T14611 T14607 ccomp suppressed,shown
R12772 T14696 T14699 nmod ICAM-1,production
R12773 T14612 T14613 nummod cdk4,expression
R12774 T14613 T14611 dobj expression,suppressed
R12775 T14614 T14613 punct ",",expression
R12776 T14615 T14616 nsubj which,is
R12777 T14616 T14613 relcl is,expression
R12778 T14617 T14616 acomp necessary,is
R12779 T14697 T14696 cc and,ICAM-1
R12780 T14618 T14616 prep for,is
R12781 T14619 T14620 det the,transition
R12782 T14620 T14618 pobj transition,for
R12783 T14698 T14699 amod TNF-α,production
R12784 T14621 T14620 prep to,transition
R12785 T14622 T14623 compound S,phase
R12786 T14623 T14621 pobj phase,to
R12787 T14699 T14692 pobj production,of
R12788 T14624 T14607 punct .,shown
R12789 T14625 T14630 advmod Finally,reported
R12790 T14700 T14684 punct ",",acquired
R12791 T14626 T14630 punct ",",reported
R12792 T14627 T14628 amod NF-κB,activation
R12793 T14628 T14630 nsubjpass activation,reported
R12794 T14701 T14684 prep via,acquired
R12795 T14629 T14630 auxpass was,reported
R12796 T14630 T14630 ROOT reported,reported
R12797 T14631 T14632 aux to,induce
R12798 T14702 T14704 det the,pathway
R12799 T14632 T14630 xcomp induce,reported
R12800 T14633 T14634 compound growth,arrest
R12801 T14703 T14704 compound NF-κB,pathway
R12802 T14634 T14632 dobj arrest,induce
R12803 T14635 T14632 prep in,induce
R12804 T14636 T14638 amod normal,keratinocytes
R12805 T14637 T14638 amod human,keratinocytes
R12806 T14704 T14701 pobj pathway,via
R12807 T14638 T14635 pobj keratinocytes,in
R12808 T14639 T14632 prep by,induce
R12809 T14705 T14684 punct .,acquired
R12810 T14640 T14641 det a,mechanims
R12811 T14641 T14639 pobj mechanims,by
R12812 T14642 T14641 acl involving,mechanims
R12813 T14706 T14708 det This,expression
R12814 T14707 T14708 amod higher,expression
R12815 T14643 T14645 det the,inhibitor
R12816 T14644 T14645 compound cdk,inhibitor
R12817 T14645 T14642 dobj inhibitor,involving
R12818 T14708 T14711 nsubj expression,resulted
R12819 T14646 T14649 nummod p21,]
R12820 T14647 T14649 nmod [,]
R12821 T14648 T14649 nummod 51,]
R12822 T14709 T14708 prep of,expression
R12823 T14649 T14645 appos ],inhibitor
R12824 T14650 T14630 punct .,reported
R12825 T14651 T14652 det The,effects
R12826 T14652 T14660 nsubj effects,remain
R12827 T14653 T14652 prep of,effects
R12828 T14710 T14709 pobj ICAM-1,of
R12829 T14654 T14653 pobj dCGN,of
R12830 T14655 T14652 prep on,effects
R12831 T14656 T14659 nummod p21,expression
R12832 T14711 T14711 ROOT resulted,resulted
R12833 T14657 T14656 cc and,p21
R12834 T14658 T14656 conj cdk4,p21
R12835 T14659 T14655 pobj expression,on
R12836 T14712 T14711 prep in,resulted
R12837 T14660 T14660 ROOT remain,remain
R12838 T14661 T14663 aux to,studied
R12839 T14713 T14712 pobj formation,in
R12840 T14662 T14663 auxpass be,studied
R12841 T14663 T14660 xcomp studied,remain
R12842 T14664 T14660 punct .,remain
R12843 T14714 T14713 prep of,formation
R12844 T14665 T14671 prep In,demonstrated
R12845 T14666 T14667 det these,studies
R12846 T14667 T14665 pobj studies,In
R12847 T14715 T14716 compound cell,aggregates
R12848 T14716 T14714 pobj aggregates,of
R12849 T14668 T14671 punct ",",demonstrated
R12850 T14717 T14716 amod similar,aggregates
R12851 T14669 T14671 nsubj we,demonstrated
R12852 T14670 T14671 aux have,demonstrated
R12853 T14671 T14671 ROOT demonstrated,demonstrated
R12854 T14718 T14717 prep to,similar
R12855 T14672 T14674 det a,action
R12856 T14673 T14674 amod direct,action
R12857 T14674 T14671 dobj action,demonstrated
R12858 T14719 T14718 pobj those,to
R12859 T14675 T14674 prep of,action
R12860 T14676 T14675 pobj dCGN,of
R12861 T14720 T14719 acl observed,those
R12862 T14721 T14720 prep in,observed
R12863 T14677 T14674 prep on,action
R12864 T14722 T14721 pobj patients,in
R12865 T14678 T14677 pobj monocytes,on
R12866 T14723 T14719 prep with,those
R12867 T14679 T14671 punct .,demonstrated
R12868 T14680 T14684 nsubj Monocytes,acquired
R12869 T14681 T14680 acl exposed,Monocytes
R12870 T14724 T14726 poss Crohn,disease
R12871 T14682 T14681 prep to,exposed
R12872 T14683 T14682 pobj dCGN,to
R12873 T14684 T14684 ROOT acquired,acquired
R12874 T14725 T14724 case 's,Crohn
R12875 T14726 T14723 pobj disease,with
R12876 T14727 T14711 punct .,resulted
R12877 T14728 T14729 nsubj We,presume
R12878 T14782 T14783 det The,way
R12879 T14729 T14729 ROOT presume,presume
R12880 T14783 T14801 nsubj way,is
R12881 T14784 T14788 prep by,leave
R12882 T14785 T14784 pobj which,by
R12883 T14730 T14741 mark that,induce
R12884 T14786 T14788 nsubj dCGN,leave
R12885 T14787 T14788 aux may,leave
R12886 T14731 T14733 det the,effects
R12887 T14788 T14783 relcl leave,way
R12888 T14789 T14791 det the,lumen
R12889 T14790 T14791 amod intestinal,lumen
R12890 T14732 T14733 compound differential,effects
R12891 T14791 T14788 dobj lumen,leave
R12892 T14792 T14788 cc and,leave
R12893 T14733 T14741 nsubj effects,induce
R12894 T14734 T14733 prep of,effects
R12895 T14793 T14788 conj cross,leave
R12896 T14735 T14739 nummod 10,dCGN
R12897 T14794 T14796 det the,barrier
R12898 T14795 T14796 amod epithelial,barrier
R12899 T14796 T14793 dobj barrier,cross
R12900 T14736 T14735 cc and,10
R12901 T14797 T14798 aux to,reach
R12902 T14798 T14793 advcl reach,cross
R12903 T14737 T14735 conj 40,10
R12904 T14799 T14800 det the,macrophages
R12905 T14800 T14798 dobj macrophages,reach
R12906 T14738 T14739 compound kDa,dCGN
R12907 T14801 T14801 ROOT is,is
R12908 T14802 T14805 det an,question
R12909 T14739 T14734 pobj dCGN,of
R12910 T14803 T14805 amod intriguing,question
R12911 T14804 T14805 amod open,question
R12912 T14740 T14741 aux to,induce
R12913 T14805 T14801 attr question,is
R12914 T14806 T14801 punct .,is
R12915 T14807 T14809 nummod One,explanation
R12916 T14741 T14729 ccomp induce,presume
R12917 T14808 T14809 amod possible,explanation
R12918 T14809 T14810 nsubj explanation,resides
R12919 T14810 T14810 ROOT resides,resides
R12920 T14742 T14743 det these,effects
R12921 T14811 T14810 prep in,resides
R12922 T14812 T14813 det the,potential
R12923 T14813 T14811 pobj potential,in
R12924 T14814 T14813 prep of,potential
R12925 T14815 T14814 pobj dCGN,of
R12926 T14816 T14817 aux to,induce
R12927 T14743 T14741 dobj effects,induce
R12928 T14817 T14810 advcl induce,resides
R12929 T14818 T14822 amod cellular,effects
R12930 T14819 T14818 cc and,cellular
R12931 T14744 T14741 prep on,induce
R12932 T14820 T14818 conj paracellular,cellular
R12933 T14821 T14822 amod injurious,effects
R12934 T14745 T14744 pobj monocytes,on
R12935 T14822 T14817 dobj effects,induce
R12936 T14823 T14817 prep at,induce
R12937 T14746 T14748 auxpass are,linked
R12938 T14824 T14828 det the,monolayer
R12939 T14825 T14827 amod intestinal,cell
R12940 T14747 T14748 advmod tightly,linked
R12941 T14826 T14827 amod epithelial,cell
R12942 T14748 T14729 conj linked,presume
R12943 T14827 T14828 compound cell,monolayer
R12944 T14828 T14823 pobj monolayer,at
R12945 T14829 T14828 appos [,monolayer
R12946 T14749 T14748 prep to,linked
R12947 T14830 T14831 nummod 48,]
R12948 T14831 T14828 appos ],monolayer
R12949 T14750 T14751 poss their,capacity
R12950 T14832 T14810 punct .,resides
R12951 T14833 T14837 prep In,inhibited
R12952 T14834 T14833 pobj conclusion,In
R12953 T14751 T14749 pobj capacity,to
R12954 T14835 T14837 punct ",",inhibited
R12955 T14836 T14837 nsubj dCGN,inhibited
R12956 T14837 T14837 ROOT inhibited,inhibited
R12957 T14752 T14753 aux to,induce
R12958 T14838 T14840 nummod THP-1,proliferation
R12959 T14839 T14840 compound cell,proliferation
R12960 T14840 T14837 dobj proliferation,inhibited
R12961 T14753 T14751 acl induce,capacity
R12962 T14841 T14837 prep in,inhibited
R12963 T14842 T14841 pobj vitro,in
R12964 T14843 T14837 punct ",",inhibited
R12965 T14754 T14753 dobj inflammation,induce
R12966 T14844 T14837 advcl accumulating,inhibited
R12967 T14845 T14846 det the,cells
R12968 T14846 T14844 dobj cells,accumulating
R12969 T14755 T14754 prep in,inflammation
R12970 T14847 T14846 prep in,cells
R12971 T14848 T14850 det the,phase
R12972 T14756 T14755 pobj vivo,in
R12973 T14849 T14850 compound G1,phase
R12974 T14850 T14847 pobj phase,in
R12975 T14851 T14850 prep of,phase
R12976 T14852 T14854 det the,cycle
R12977 T14853 T14854 compound cell,cycle
R12978 T14854 T14851 pobj cycle,of
R12979 T14757 T14729 punct .,presume
R12980 T14855 T14837 punct ",",inhibited
R12981 T14856 T14858 amod increased,expression
R12982 T14857 T14858 compound ICAM-1,expression
R12983 T14758 T14766 advmod However,come
R12984 T14858 T14837 dobj expression,inhibited
R12985 T14859 T14837 punct ",",inhibited
R12986 T14759 T14766 punct ",",come
R12987 T14860 T14837 conj stimulated,inhibited
R12988 T14861 T14863 amod ICAM-1-dependent,aggregation
R12989 T14862 T14863 compound monocyte,aggregation
R12990 T14760 T14766 prep in,come
R12991 T14863 T14860 dobj aggregation,stimulated
R12992 T14864 T14860 prep in,stimulated
R12993 T14761 T14760 pobj vivo,in
R12994 T14865 T14864 pobj vitro,in
R12995 T14866 T14860 punct ",",stimulated
R12996 T14867 T14860 cc and,stimulated
R12997 T14762 T14766 punct ",",come
R12998 T14868 T14860 conj stimulated,stimulated
R12999 T14869 T14870 compound TNF-α,expression
R13000 T14763 T14766 nsubj macrophages,come
R13001 T14870 T14868 dobj expression,stimulated
R13002 T14871 T14870 cc and,expression
R13003 T14872 T14870 conj secretion,expression
R13004 T14764 T14766 aux do,come
R13005 T14873 T14837 punct .,inhibited
R13006 T14874 T14875 det These,responses
R13007 T14875 T14876 nsubj responses,were
R13008 T14765 T14766 neg not,come
R13009 T14876 T14876 ROOT were,were
R13010 T14877 T14878 advmod more,pronounced
R13011 T14878 T14876 acomp pronounced,were
R13012 T14766 T14766 ROOT come,come
R13013 T14767 T14766 prep in,come
R13014 T14879 T14876 advcl following,were
R13015 T14768 T14769 amod direct,contact
R13016 T14880 T14882 nummod 40,dCGN
R13017 T14881 T14882 compound kDa,dCGN
R13018 T14769 T14767 pobj contact,in
R13019 T14882 T14879 dobj dCGN,following
R13020 T14883 T14876 punct ",",were
R13021 T14770 T14769 prep with,contact
R13022 T14884 T14876 cc and,were
R13023 T14771 T14773 det the,lumen
R13024 T14885 T14887 auxpass were,linked
R13025 T14886 T14887 dep all,linked
R13026 T14887 T14876 conj linked,were
R13027 T14888 T14887 prep to,linked
R13028 T14889 T14890 compound NF-κB,activation
R13029 T14772 T14773 amod intestinal,lumen
R13030 T14890 T14888 pobj activation,to
R13031 T14891 T14876 punct .,were
R13032 T14892 T14893 det These,results
R13033 T14773 T14770 pobj lumen,with
R13034 T14893 T14894 nsubj results,suggest
R13035 T14894 T14894 ROOT suggest,suggest
R13036 T14774 T14766 cc and,come
R13037 T14895 T14910 mark that,have
R13038 T14896 T14910 punct ",",have
R13039 T14897 T14901 mark although,used
R13040 T14775 T14776 auxpass are,separated
R13041 T14898 T14901 nsubjpass CGN,used
R13042 T14776 T14766 conj separated,come
R13043 T14899 T14901 auxpass is,used
R13044 T14777 T14776 agent by,separated
R13045 T14900 T14901 advmod widely,used
R13046 T14901 T14910 advcl used,have
R13047 T14902 T14901 prep as,used
R13048 T14778 T14780 det the,barrier
R13049 T14903 T14905 det a,additive
R13050 T14904 T14905 compound food,additive
R13051 T14779 T14780 amod epithelial,barrier
R13052 T14905 T14902 pobj additive,as
R13053 T14906 T14910 punct ",",have
R13054 T14907 T14909 poss its,forms
R13055 T14780 T14777 pobj barrier,by
R13056 T14908 T14909 amod degraded,forms
R13057 T14909 T14910 nsubj forms,have
R13058 T14781 T14766 punct .,come
R13059 T14910 T14894 ccomp have,suggest
R13060 T14911 T14913 det an,effect
R13062 T14912 T14913 amod important,effect
R13063 T14913 T14910 dobj effect,have
R13064 T14914 T14913 prep on,effect
R13065 T14915 T14914 pobj monocytes,on
R13066 T14916 T14915 amod characteristic,monocytes
R13067 T14917 T14916 prep of,characteristic
R13068 T14918 T14920 det an,phenotype
R13069 T14919 T14920 amod inflammatory,phenotype
R13070 T14920 T14917 pobj phenotype,of
R13071 T14921 T14894 punct .,suggest
R11432 T13283 T13282 pobj infiltration,with
R11433 T13284 T13283 cc and,infiltration
R11434 T13285 T13283 conj activation,infiltration
R11435 T13286 T13283 prep of,infiltration
R11436 T13287 T13288 amod intestinal,macrophages
R11437 T13288 T13286 pobj macrophages,of
R11438 T13289 T13291 nmod [,]
R11439 T13290 T13291 nummod 17,]
R11423 T13274 T13281 nsubjpass Inflammation,associated
R11424 T13275 T13274 prep of,Inflammation
R11425 T13276 T13278 det the,tract
R11426 T13277 T13278 amod intestinal,tract
R11427 T13278 T13275 pobj tract,of
R11428 T13279 T13281 auxpass is,associated
R11429 T13280 T13281 advmod usually,associated
R11430 T13281 T13281 ROOT associated,associated
R11431 T13282 T13281 prep with,associated
R11464 T13315 T13313 dobj inflammation,inhibit
R11465 T13316 T13304 punct .,induced
R11466 T13317 T13340 nsubj Accumulation,followed
R11467 T13318 T13317 prep of,Accumulation
R11468 T13319 T13320 amod different,types
R11469 T13320 T13318 pobj types,of
R11470 T13321 T13320 prep of,types
R11471 T13322 T13321 pobj leukocytes,of
R11472 T13323 T13322 punct ",",leukocytes
R11473 T13324 T13320 prep including,types
R11474 T13325 T13324 pobj monocytes/macrophages,including
R11475 T13326 T13325 punct ",",monocytes/macrophages
R11476 T13327 T13325 conj neutrophils,monocytes/macrophages
R11477 T13328 T13327 punct ",",neutrophils
R11478 T13329 T13327 cc and,neutrophils
R11479 T13330 T13327 conj lymphocytes,neutrophils
R11480 T13331 T13325 prep in,monocytes/macrophages
R11481 T13332 T13334 det the,mucosa
R11486 T13337 T13340 punct ",",followed
R11487 T13338 T13340 auxpass is,followed
R11488 T13339 T13340 advmod normally,followed
R11489 T13340 T13340 ROOT followed,followed
R11490 T13341 T13340 agent by,followed
R11491 T13342 T13341 pobj secretion,by
R11492 T13343 T13342 prep of,secretion
R11493 T13344 T13345 amod pro-inflammatory,cytokines
R11494 T13345 T13343 pobj cytokines,of
R11495 T13346 T13348 nmod [,]
R11496 T13347 T13348 nummod 33,]
R11497 T13348 T13342 appos ],secretion
R11498 T13349 T13340 punct .,followed
R11499 T13350 T13351 amod Several,stimuli
R11500 T13351 T13353 nsubj stimuli,induce
R11501 T13352 T13353 aux can,induce
R11692 T13618 T13618 ROOT analyzed,analyzed
R11955 T13785 T13786 advmod very,few
R11957 T13786 T13788 amod few,cells
R12333 T14205 T14204 pobj dCGN,for
R12335 T14206 T14203 prep than,site
R12336 T14207 T14206 prep for,than
R12337 T14208 T14207 pobj LPS,for
R12340 T14209 T14199 punct ",",have
R12342 T14210 T14199 advmod however,have
R12343 T14211 T14214 punct ",",remains
R12345 T14212 T14213 det this,hypothesis
R12716 T14573 T14566 punct ",",reported
R12718 T14574 T14566 advcl arresting,reported
R12719 T14575 T14576 compound cell,proliferation
R12721 T14576 T14574 dobj proliferation,arresting
R12722 T14577 T14579 nmod [,]
R12723 T14578 T14579 nummod 49,]
R12724 T14579 T14576 appos ],proliferation
R12725 T14580 T14566 punct .,reported
R12727 T14581 T14582 amod Such,relationship
R12728 T14582 T14592 nsubjpass relationship,reported
R12729 T14583 T14582 prep between,relationship
R12731 T14584 T14585 compound NF-kB,activation
R12732 T14585 T14583 pobj activation,between
R12734 T14586 T14585 cc and,activation
R12735 T14587 T14588 compound cell,cycle
R12738 T14588 T14585 conj cycle,activation
R12739 T14589 T14585 conj regulation,activation

UBERON-AE

Id Subject Object Predicate Lexical cue
T11445 31-41 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11446 106-116 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11447 406-416 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11448 1630-1640 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11449 2058-2068 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11450 2684-2694 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11451 2893-2903 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11452 8218-8228 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11453 8316-8326 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T11454 1962-1971 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T11455 406-423 http://purl.obolibrary.org/obo/UBERON_0001242 denotes intestinal mucosa
T11456 2058-2075 http://purl.obolibrary.org/obo/UBERON_0001242 denotes intestinal mucosa
T11457 2684-2701 http://purl.obolibrary.org/obo/UBERON_0001242 denotes intestinal mucosa
T11458 417-423 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T11459 2069-2075 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T11460 2695-2701 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T11461 2809-2815 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T11462 1956-1971 http://purl.obolibrary.org/obo/UBERON_0000059 denotes large intestine
T11463 2502-2509 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T11464 4838-4845 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T11465 6912-6919 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonic
T11466 2904-2910 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T11467 8544-8565 http://purl.obolibrary.org/obo/UBERON_0001277 denotes intestinal epithelial

sentences

Id Subject Object Predicate Lexical cue
T11576 11-134 Sentence denotes Inflammation of the intestinal tract is usually associated with infiltration and activation of intestinal macrophages [17].
T11577 135-289 Sentence denotes These macrophages are able to initiate immune responses and can be induced to differentiate into cells that either exacerbate or inhibit the inflammation.
T11578 290-514 Sentence denotes Accumulation of different types of leukocytes, including monocytes/macrophages, neutrophils, and lymphocytes in the intestinal mucosa during inflammation, is normally followed by secretion of pro-inflammatory cytokines [33].
T11579 515-612 Sentence denotes Several stimuli can induce these leukocytes to produce and secrete cytokines during inflammation.
T11580 613-719 Sentence denotes One of the most potent and known stimuli for leukocyte activation is LPS from Gram-negative bacteria [34].
T11581 720-828 Sentence denotes In addition, other factors are also able to stimulate cytokine secretion from various leukocytes [35], [36].
T11582 829-960 Sentence denotes One such factor is CGN, a high molecular weight sulphated polysaccharide (>200 kDa) derived from red algae (Rhodophyceae) [1], [2].
T11583 961-1033 Sentence denotes Native CGN is widely used as a food additive (E 407) to improve texture.
T11584 1034-1083 Sentence denotes It is also used in cosmetics and pharmaceuticals.
T11585 1084-1274 Sentence denotes Although native form CGN (200–800 kDa) has been declared harmless to humans [8], its degraded forms (<50 kDa), also known as poligeenan, are widely used to induce colitis in rodents [3]–[5].
T11586 1275-1389 Sentence denotes These degraded CGN may also have a possible carcinogenic effect [4], [6]–[8]; however this is still controversial.
T11587 1390-1661 Sentence denotes Although acid treatment at high temperature (80°C) is required for CGN hydrolysis in vitro to lower molecular weight dCGN, it is probable that some dCGN are produced by acid hydrolysis during gastric digestion [9], [10] or interaction with intestinal bacteria [11], [12].
T11588 1662-1755 Sentence denotes Thus, understanding the mechanisms of dCGN-induced bowel inflammation is of great importance.
T11589 1756-1862 Sentence denotes In this report, we have analyzed the role of human monocytes (PBM and THP-1) in dCGN-induced inflammation.
T11590 1863-2117 Sentence denotes Preliminary in vivo studies in rats treated with dCGN revealed significant shortening of the large intestine associated with an inflammatory state, i.e. strong infiltration of macrophages to the intestinal mucosa similar to DSS-induced inflammation [20].
T11591 2118-2320 Sentence denotes Using two fractions of dCGN (10 and 40 kDa), we observed a strong correlation between the severity of the inflammation and the dCGN molecular size, thus confirming the size related inflammation in vivo.
T11592 2321-2446 Sentence denotes This macrophage accumulation was not due to cell proliferation because dCGN inhibited THP-1 monocytes proliferation in vitro.
T11593 2447-2586 Sentence denotes These results are similar to those obtained with human colonic epithelial cells (NCM460 cell line) exposed to native CGN for 1–8 days [37].
T11594 2587-2741 Sentence denotes Thus, it seems that dCGN promote macrophage infiltration by recruiting new cells to the inflamed intestinal mucosa and not by inducing cell proliferation.
T11595 2742-2911 Sentence denotes In addition, very few polymorphonuclear cells were detected in the mucosa at the time point analyzed as demonstrated by a very low level of MPO in the intestinal tissue.
T11596 2912-3037 Sentence denotes These results suggest that monocytes might produce cytokines associated with activation into macrophages in response to dCGN.
T11597 3038-3126 Sentence denotes Thus, we analyzed the production of TNF by both PBM and THP-1 cells in response to dCGN.
T11598 3127-3188 Sentence denotes Degraded CGN induced a robust production of TNF by monocytes.
T11599 3189-3289 Sentence denotes The 40 kDa form of dCGN was more potent for monocyte stimulation than the 10 kDa or the native ones.
T11600 3290-3496 Sentence denotes Surprisingly, monocyte activation by dCGN to produce TNF was much stronger than the activation induced by LPS, an inflammatory factor considered to be among the most potent stimuli for leukocyte activation.
T11601 3497-3599 Sentence denotes These results underline the fact that partially degraded forms of CGN have important cellular effects.
T11602 3600-3708 Sentence denotes The amount of TNF secreted by PBM induced with LPS was much larger than the one secreted by THP-1 monocytes.
T11603 3709-3931 Sentence denotes Since monocyte activation by LPS is associated with the presence of the CD14 and TLR4 receptors [38]–[40], the different response observed could be due to the different expression of these receptors in PBM and THP-1 cells.
T11604 3932-4001 Sentence denotes CD14 is not expressed by THP-1 monocytes, but it is expressed by PBM.
T11605 4002-4160 Sentence denotes This fact could explain why THP-1 cells produced a much smaller response to LPS than PBM and also the difference of kinetics in the LPS induced TNF secretion.
T11606 4161-4336 Sentence denotes The peak of TNF response was observed after 8 h stimulation followed by a rapid decrease to baseline at 10 h, whereas on THP-1 cells the peak was not reached until after 56 h.
T11607 4337-4449 Sentence denotes Moreover, the amount of TNF secreted by monocytes induced with dCGN was much larger than the one induced by LPS.
T11608 4450-4544 Sentence denotes On the other hand, LPS and dCGN displayed a very different TNF secretion curve in THP-1 cells.
T11609 4545-4631 Sentence denotes These differences suggest that dCGN and LPS could use different activation mechanisms.
T11610 4632-4755 Sentence denotes It is noteworthy that neutralizing antibody to CD14 only partially (<40%) inhibited dCGN-induced TNF secretion (not shown).
T11611 4756-4868 Sentence denotes TLR4 has been recently identified as a surface membrane receptor for CGN in human colonic epithelial cells [41].
T11612 4869-4963 Sentence denotes Thus, it is possible that TLR4 is activated by dCGN to induce cytokine secretion by monocytes.
T11613 4964-5105 Sentence denotes We can only speculate that TLR4 may have a higher affinity-binding site for dCGN than for LPS, however, this hypothesis remains to be tested.
T11614 5106-5298 Sentence denotes Another indicator that dCGN stimulate monocytes leading to a more active phenotype is the fact that surface expression of the adhesion molecule ICAM-1 was enhanced in both PBM and THP-1 cells.
T11615 5299-5449 Sentence denotes The over expression of ICAM-1 caused the activated monocytes to form cell aggregates that were more abundant among cells treated with the 40 kDa dCGN.
T11616 5450-5602 Sentence denotes This correlates with the higher expression of ICAM-1 induced by the 40 kDa dCGN, suggesting that the partially degraded CGN is more biologically active.
T11617 5603-5758 Sentence denotes In addition, the cell aggregates are reminiscent of monocyte aggregates, which form multinucleated giant cells (MGC) in patients with Crohn's disease [42].
T11618 5759-5862 Sentence denotes These giant cells were not observed in healthy individuals or in patients with ulcerative colitis [42].
T11619 5863-6006 Sentence denotes Moreover, increased expression levels of ICAM-1 and LFA-3 (CD58) were also detected in monocytes from patients with Crohn's disease [43], [44].
T11620 6007-6270 Sentence denotes Thus, degraded CGN clearly can activate monocytes to express an increased number of ICAM-1 adhesion molecules, therefore being capable of creating the conditions characteristic of Crohn's disease symptomatology, i.e. PBM accumulation and MGC formation [45], [46].
T11621 6271-6349 Sentence denotes The NF-κB pathway regulates genes responsible for ICAM-1 and TNF-α expression.
T11622 6350-6436 Sentence denotes NF-κB activation is associated with the degradation of the inhibitor protein IκB [47].
T11623 6437-6631 Sentence denotes Indeed, dCGN induced NF-κB activation as shown by degradation of IκBα, translocation of p65 and p50 sub-units to the nucleus and by activation of an NF-κB-responsive luciferase reporter plasmid.
T11624 6632-6797 Sentence denotes Again, a stronger activation of NF-κB was induced by the 40 kDa dCGN compared to 10 kDa dCGN, suggesting that the partially degraded CGN is more biologically active.
T11625 6798-6942 Sentence denotes Our data are in agreement with a previous study showing that native CGN also induced activation of NF-κB in human colonic epithelial cells [48].
T11626 6943-7132 Sentence denotes NF-κB pathway is often associated to promote cell survival and cancer cell growth, however it has been sometimes reported to behave as a tumor suppressor, arresting cell proliferation [49].
T11627 7133-7257 Sentence denotes Such relationship between NF-kB activation and cell cycle regulation has been reported in normal human epidermal cells [50].
T11628 7258-7383 Sentence denotes Indeed, it has been shown that NF-κB activation suppressed cdk4 expression, which is necessary for the transition to S phase.
T11629 7384-7529 Sentence denotes Finally, NF-κB activation was reported to induce growth arrest in normal human keratinocytes by a mechanims involving the cdk inhibitor p21 [51].
T11630 7530-7598 Sentence denotes The effects of dCGN on p21 and cdk4 expression remain to be studied.
T11631 7599-7675 Sentence denotes In these studies, we have demonstrated a direct action of dCGN on monocytes.
T11632 7676-7845 Sentence denotes Monocytes exposed to dCGN acquired an inflammatory phenotype that included higher expression of the adhesion molecule ICAM-1 and TNF-α production, via the NF-κB pathway.
T11633 7846-7979 Sentence denotes This higher expression of ICAM-1 resulted in formation of cell aggregates similar to those observed in patients with Crohn's disease.
T11634 7980-8148 Sentence denotes We presume that the differential effects of 10 and 40 kDa dCGN to induce these effects on monocytes are tightly linked to their capacity to induce inflammation in vivo.
T11635 8149-8279 Sentence denotes However, in vivo, macrophages do not come in direct contact with the intestinal lumen and are separated by the epithelial barrier.
T11636 8280-8422 Sentence denotes The way by which dCGN may leave the intestinal lumen and cross the epithelial barrier to reach the macrophages is an intriguing open question.
T11637 8423-8586 Sentence denotes One possible explanation resides in the potential of dCGN to “induce” cellular and paracellular injurious effects at the intestinal epithelial cell monolayer [48].
T11638 8587-8844 Sentence denotes In conclusion, dCGN inhibited THP-1 cell proliferation in vitro, accumulating the cells in the G1 phase of the cell cycle, increased ICAM-1 expression, stimulated ICAM-1-dependent monocyte aggregation in vitro, and stimulated TNF-α expression and secretion.
T11639 8845-8945 Sentence denotes These responses were more pronounced following 40 kDa dCGN, and were all linked to NF-κB activation.
T11640 8946-9123 Sentence denotes These results suggest that, although CGN is widely used as a food additive, its degraded forms have an important effect on monocytes characteristic of an inflammatory phenotype.
T262 0-10 Sentence denotes Discussion
T263 11-134 Sentence denotes Inflammation of the intestinal tract is usually associated with infiltration and activation of intestinal macrophages [17].
T264 135-289 Sentence denotes These macrophages are able to initiate immune responses and can be induced to differentiate into cells that either exacerbate or inhibit the inflammation.
T265 290-514 Sentence denotes Accumulation of different types of leukocytes, including monocytes/macrophages, neutrophils, and lymphocytes in the intestinal mucosa during inflammation, is normally followed by secretion of pro-inflammatory cytokines [33].
T266 515-612 Sentence denotes Several stimuli can induce these leukocytes to produce and secrete cytokines during inflammation.
T267 613-719 Sentence denotes One of the most potent and known stimuli for leukocyte activation is LPS from Gram-negative bacteria [34].
T268 720-828 Sentence denotes In addition, other factors are also able to stimulate cytokine secretion from various leukocytes [35], [36].
T269 829-960 Sentence denotes One such factor is CGN, a high molecular weight sulphated polysaccharide (>200 kDa) derived from red algae (Rhodophyceae) [1], [2].
T270 961-1033 Sentence denotes Native CGN is widely used as a food additive (E 407) to improve texture.
T271 1034-1083 Sentence denotes It is also used in cosmetics and pharmaceuticals.
T272 1084-1274 Sentence denotes Although native form CGN (200–800 kDa) has been declared harmless to humans [8], its degraded forms (<50 kDa), also known as poligeenan, are widely used to induce colitis in rodents [3]–[5].
T273 1275-1389 Sentence denotes These degraded CGN may also have a possible carcinogenic effect [4], [6]–[8]; however this is still controversial.
T274 1390-1661 Sentence denotes Although acid treatment at high temperature (80°C) is required for CGN hydrolysis in vitro to lower molecular weight dCGN, it is probable that some dCGN are produced by acid hydrolysis during gastric digestion [9], [10] or interaction with intestinal bacteria [11], [12].
T275 1662-1755 Sentence denotes Thus, understanding the mechanisms of dCGN-induced bowel inflammation is of great importance.
T276 1756-1862 Sentence denotes In this report, we have analyzed the role of human monocytes (PBM and THP-1) in dCGN-induced inflammation.
T277 1863-2117 Sentence denotes Preliminary in vivo studies in rats treated with dCGN revealed significant shortening of the large intestine associated with an inflammatory state, i.e. strong infiltration of macrophages to the intestinal mucosa similar to DSS-induced inflammation [20].
T278 2118-2320 Sentence denotes Using two fractions of dCGN (10 and 40 kDa), we observed a strong correlation between the severity of the inflammation and the dCGN molecular size, thus confirming the size related inflammation in vivo.
T279 2321-2446 Sentence denotes This macrophage accumulation was not due to cell proliferation because dCGN inhibited THP-1 monocytes proliferation in vitro.
T280 2447-2586 Sentence denotes These results are similar to those obtained with human colonic epithelial cells (NCM460 cell line) exposed to native CGN for 1–8 days [37].
T281 2587-2741 Sentence denotes Thus, it seems that dCGN promote macrophage infiltration by recruiting new cells to the inflamed intestinal mucosa and not by inducing cell proliferation.
T282 2742-2911 Sentence denotes In addition, very few polymorphonuclear cells were detected in the mucosa at the time point analyzed as demonstrated by a very low level of MPO in the intestinal tissue.
T283 2912-3037 Sentence denotes These results suggest that monocytes might produce cytokines associated with activation into macrophages in response to dCGN.
T284 3038-3126 Sentence denotes Thus, we analyzed the production of TNF by both PBM and THP-1 cells in response to dCGN.
T285 3127-3188 Sentence denotes Degraded CGN induced a robust production of TNF by monocytes.
T286 3189-3289 Sentence denotes The 40 kDa form of dCGN was more potent for monocyte stimulation than the 10 kDa or the native ones.
T287 3290-3496 Sentence denotes Surprisingly, monocyte activation by dCGN to produce TNF was much stronger than the activation induced by LPS, an inflammatory factor considered to be among the most potent stimuli for leukocyte activation.
T288 3497-3599 Sentence denotes These results underline the fact that partially degraded forms of CGN have important cellular effects.
T289 3600-3708 Sentence denotes The amount of TNF secreted by PBM induced with LPS was much larger than the one secreted by THP-1 monocytes.
T290 3709-3931 Sentence denotes Since monocyte activation by LPS is associated with the presence of the CD14 and TLR4 receptors [38]–[40], the different response observed could be due to the different expression of these receptors in PBM and THP-1 cells.
T291 3932-4001 Sentence denotes CD14 is not expressed by THP-1 monocytes, but it is expressed by PBM.
T292 4002-4160 Sentence denotes This fact could explain why THP-1 cells produced a much smaller response to LPS than PBM and also the difference of kinetics in the LPS induced TNF secretion.
T293 4161-4336 Sentence denotes The peak of TNF response was observed after 8 h stimulation followed by a rapid decrease to baseline at 10 h, whereas on THP-1 cells the peak was not reached until after 56 h.
T294 4337-4449 Sentence denotes Moreover, the amount of TNF secreted by monocytes induced with dCGN was much larger than the one induced by LPS.
T295 4450-4544 Sentence denotes On the other hand, LPS and dCGN displayed a very different TNF secretion curve in THP-1 cells.
T296 4545-4631 Sentence denotes These differences suggest that dCGN and LPS could use different activation mechanisms.
T297 4632-4755 Sentence denotes It is noteworthy that neutralizing antibody to CD14 only partially (<40%) inhibited dCGN-induced TNF secretion (not shown).
T298 4756-4868 Sentence denotes TLR4 has been recently identified as a surface membrane receptor for CGN in human colonic epithelial cells [41].
T299 4869-4963 Sentence denotes Thus, it is possible that TLR4 is activated by dCGN to induce cytokine secretion by monocytes.
T300 4964-5105 Sentence denotes We can only speculate that TLR4 may have a higher affinity-binding site for dCGN than for LPS, however, this hypothesis remains to be tested.
T301 5106-5298 Sentence denotes Another indicator that dCGN stimulate monocytes leading to a more active phenotype is the fact that surface expression of the adhesion molecule ICAM-1 was enhanced in both PBM and THP-1 cells.
T302 5299-5449 Sentence denotes The over expression of ICAM-1 caused the activated monocytes to form cell aggregates that were more abundant among cells treated with the 40 kDa dCGN.
T303 5450-5602 Sentence denotes This correlates with the higher expression of ICAM-1 induced by the 40 kDa dCGN, suggesting that the partially degraded CGN is more biologically active.
T304 5603-5758 Sentence denotes In addition, the cell aggregates are reminiscent of monocyte aggregates, which form multinucleated giant cells (MGC) in patients with Crohn's disease [42].
T305 5759-5862 Sentence denotes These giant cells were not observed in healthy individuals or in patients with ulcerative colitis [42].
T306 5863-6006 Sentence denotes Moreover, increased expression levels of ICAM-1 and LFA-3 (CD58) were also detected in monocytes from patients with Crohn's disease [43], [44].
T307 6007-6270 Sentence denotes Thus, degraded CGN clearly can activate monocytes to express an increased number of ICAM-1 adhesion molecules, therefore being capable of creating the conditions characteristic of Crohn's disease symptomatology, i.e. PBM accumulation and MGC formation [45], [46].
T308 6271-6349 Sentence denotes The NF-κB pathway regulates genes responsible for ICAM-1 and TNF-α expression.
T309 6350-6436 Sentence denotes NF-κB activation is associated with the degradation of the inhibitor protein IκB [47].
T310 6437-6631 Sentence denotes Indeed, dCGN induced NF-κB activation as shown by degradation of IκBα, translocation of p65 and p50 sub-units to the nucleus and by activation of an NF-κB-responsive luciferase reporter plasmid.
T311 6632-6797 Sentence denotes Again, a stronger activation of NF-κB was induced by the 40 kDa dCGN compared to 10 kDa dCGN, suggesting that the partially degraded CGN is more biologically active.
T312 6798-6942 Sentence denotes Our data are in agreement with a previous study showing that native CGN also induced activation of NF-κB in human colonic epithelial cells [48].
T313 6943-7132 Sentence denotes NF-κB pathway is often associated to promote cell survival and cancer cell growth, however it has been sometimes reported to behave as a tumor suppressor, arresting cell proliferation [49].
T314 7133-7257 Sentence denotes Such relationship between NF-kB activation and cell cycle regulation has been reported in normal human epidermal cells [50].
T315 7258-7383 Sentence denotes Indeed, it has been shown that NF-κB activation suppressed cdk4 expression, which is necessary for the transition to S phase.
T316 7384-7529 Sentence denotes Finally, NF-κB activation was reported to induce growth arrest in normal human keratinocytes by a mechanims involving the cdk inhibitor p21 [51].
T317 7530-7598 Sentence denotes The effects of dCGN on p21 and cdk4 expression remain to be studied.
T318 7599-7675 Sentence denotes In these studies, we have demonstrated a direct action of dCGN on monocytes.
T319 7676-7845 Sentence denotes Monocytes exposed to dCGN acquired an inflammatory phenotype that included higher expression of the adhesion molecule ICAM-1 and TNF-α production, via the NF-κB pathway.
T320 7846-7979 Sentence denotes This higher expression of ICAM-1 resulted in formation of cell aggregates similar to those observed in patients with Crohn's disease.
T321 7980-8148 Sentence denotes We presume that the differential effects of 10 and 40 kDa dCGN to induce these effects on monocytes are tightly linked to their capacity to induce inflammation in vivo.
T322 8149-8279 Sentence denotes However, in vivo, macrophages do not come in direct contact with the intestinal lumen and are separated by the epithelial barrier.
T323 8280-8422 Sentence denotes The way by which dCGN may leave the intestinal lumen and cross the epithelial barrier to reach the macrophages is an intriguing open question.
T324 8423-8586 Sentence denotes One possible explanation resides in the potential of dCGN to “induce” cellular and paracellular injurious effects at the intestinal epithelial cell monolayer [48].
T325 8587-8844 Sentence denotes In conclusion, dCGN inhibited THP-1 cell proliferation in vitro, accumulating the cells in the G1 phase of the cell cycle, increased ICAM-1 expression, stimulated ICAM-1-dependent monocyte aggregation in vitro, and stimulated TNF-α expression and secretion.
T326 8845-8945 Sentence denotes These responses were more pronounced following 40 kDa dCGN, and were all linked to NF-κB activation.
T327 8946-9123 Sentence denotes These results suggest that, although CGN is widely used as a food additive, its degraded forms have an important effect on monocytes characteristic of an inflammatory phenotype.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T15327 3060-3070 Gene_expression denotes production
T15328 3074-3077 Protein denotes TNF
T15329 3106-3120 Positive_regulation denotes in response to
T15330 3140-3147 Positive_regulation denotes induced
T15331 3157-3167 Gene_expression denotes production
T15332 3171-3174 Protein denotes TNF
T15333 3335-3342 Gene_expression denotes produce
T15334 3343-3346 Protein denotes TNF
T15335 3614-3617 Protein denotes TNF
T15336 3618-3626 Localization denotes secreted
T15337 3634-3641 Positive_regulation denotes induced
T15338 3680-3688 Localization denotes secreted
T15339 3765-3773 Localization denotes presence
T15340 3765-3773 Localization denotes presence
T15341 3781-3785 Protein denotes CD14
T15342 3790-3804 Protein denotes TLR4 receptors
T15343 3878-3888 Gene_expression denotes expression
T15344 3878-3888 Gene_expression denotes expression
T15345 3932-3936 Protein denotes CD14
T15346 3944-3953 Gene_expression denotes expressed true
T15347 3984-3993 Gene_expression denotes expressed
T15348 4138-4145 Positive_regulation denotes induced
T15349 4146-4149 Protein denotes TNF
T15350 4150-4159 Localization denotes secretion
T15351 4173-4176 Protein denotes TNF
T15352 4177-4185 Regulation denotes response
T15353 4241-4249 Negative_regulation denotes decrease
T15354 4361-4364 Protein denotes TNF
T15355 4365-4373 Localization denotes secreted
T15356 4387-4394 Positive_regulation denotes induced
T15357 4509-4512 Protein denotes TNF
T15358 4513-4522 Localization denotes secretion
T15359 4706-4715 Negative_regulation denotes inhibited
T15360 4721-4728 Positive_regulation denotes induced
T15361 4729-4732 Protein denotes TNF
T15362 4733-4742 Localization denotes secretion
T15363 4756-4760 Protein denotes TLR4
T15364 4812-4820 Protein denotes receptor
T15365 4895-4899 Protein denotes TLR4
T15366 4903-4912 Positive_regulation denotes activated
T15367 4991-4995 Protein denotes TLR4
T15368 5214-5224 Gene_expression denotes expression
T15369 5232-5249 Protein denotes adhesion molecule
T15370 5250-5256 Protein denotes ICAM-1
T15371 5261-5269 Positive_regulation denotes enhanced
T15372 5308-5318 Gene_expression denotes expression
T15373 5322-5328 Protein denotes ICAM-1
T15374 5482-5492 Gene_expression denotes expression
T15375 5496-5502 Protein denotes ICAM-1
T15376 5503-5510 Positive_regulation denotes induced
T15377 5873-5882 Positive_regulation denotes increased
T15378 5873-5882 Positive_regulation denotes increased
T15379 5883-5893 Gene_expression denotes expression
T15380 5883-5893 Gene_expression denotes expression
T15381 5904-5910 Protein denotes ICAM-1
T15382 5915-5920 Protein denotes LFA-3
T15383 5922-5926 Protein denotes CD58
T15384 6060-6067 Gene_expression denotes express
T15385 6071-6080 Positive_regulation denotes increased
T15386 6091-6097 Protein denotes ICAM-1
T15387 6098-6116 Protein denotes adhesion molecules
T15388 6289-6298 Regulation denotes regulates
T15389 6289-6298 Regulation denotes regulates
T15390 6305-6316 Regulation denotes responsible
T15391 6305-6316 Regulation denotes responsible
T15392 6321-6327 Protein denotes ICAM-1
T15393 6332-6337 Protein denotes TNF-α
T15394 6338-6348 Gene_expression denotes expression
T15395 6338-6348 Gene_expression denotes expression
T15396 6487-6498 Protein_catabolism denotes degradation
T15397 6502-6506 Protein denotes IκBα
T15398 6508-6521 Localization denotes translocation
T15399 6508-6521 Localization denotes translocation
T15400 6525-6528 Protein denotes p65
T15401 6533-6536 Protein denotes p50
T15402 6554-6561 Entity denotes nucleus
T15403 6569-6579 Positive_regulation denotes activation
T15404 6592-6602 Regulation denotes responsive
T15405 6603-6613 Protein denotes luciferase
T15406 7306-7316 Negative_regulation denotes suppressed
T15407 7317-7321 Protein denotes cdk4
T15408 7322-7332 Gene_expression denotes expression
T15409 7520-7523 Protein denotes p21
T15410 7534-7541 Regulation denotes effects true
T15411 7534-7541 Regulation denotes effects true
T15412 7553-7556 Protein denotes p21
T15413 7561-7565 Protein denotes cdk4
T15414 7566-7576 Gene_expression denotes expression
T15415 7566-7576 Gene_expression denotes expression
T15416 7751-7757 Positive_regulation denotes higher
T15417 7751-7757 Positive_regulation denotes higher
T15418 7758-7768 Gene_expression denotes expression
T15419 7794-7800 Protein denotes ICAM-1
T15420 7805-7810 Protein denotes TNF-α
T15421 7811-7821 Gene_expression denotes production
T15422 7851-7857 Positive_regulation denotes higher
T15423 7858-7868 Gene_expression denotes expression
T15424 7872-7878 Protein denotes ICAM-1
T15425 8046-8052 Positive_regulation denotes induce
T15426 8710-8719 Positive_regulation denotes increased
T15427 8720-8726 Protein denotes ICAM-1
T15428 8727-8737 Gene_expression denotes expression
T15429 8750-8756 Protein denotes ICAM-1
T15430 8802-8812 Positive_regulation denotes stimulated
T15431 8802-8812 Positive_regulation denotes stimulated
T15432 8813-8818 Protein denotes TNF-α
T15433 8819-8829 Gene_expression denotes expression
T15434 8834-8843 Localization denotes secretion
R13161 T15327 T15329 themeOf production,in response to
R13163 T15328 T15327 themeOf TNF,production
R13166 T15331 T15330 themeOf production,induced
R13169 T15332 T15331 themeOf TNF,production
R13171 T15334 T15333 themeOf TNF,produce
R13174 T15335 T15336 themeOf TNF,secreted
R13176 T15335 T15338 themeOf TNF,secreted
R13177 T15336 T15337 themeOf secreted,induced
R13184 T15341 T15339 themeOf CD14,presence
R13188 T15341 T15344 themeOf CD14,expression
R13190 T15342 T15340 themeOf TLR4 receptors,presence
R13194 T15342 T15343 themeOf TLR4 receptors,expression
R13195 T15345 T15346 themeOf CD14,expressed
R13198 T15345 T15347 themeOf CD14,expressed
R13202 T15349 T15350 themeOf TNF,secretion
R13207 T15350 T15348 themeOf secretion,induced
R13208 T15351 T15352 themeOf TNF,response
R13211 T15352 T15353 themeOf response,decrease
R13214 T15354 T15355 themeOf TNF,secreted
R13218 T15355 T15356 themeOf secreted,induced
R13221 T15357 T15358 themeOf TNF,secretion
R13224 T15360 T15359 themeOf induced,inhibited
R13227 T15361 T15362 themeOf TNF,secretion
R13232 T15362 T15360 themeOf secretion,induced
R13233 T15365 T15366 themeOf TLR4,activated
R13234 T15368 T15371 themeOf expression,enhanced
R13235 T15384 T15385 themeOf express,increased
R13236 T15370 T15368 themeOf ICAM-1,expression
R13237 T15386 T15384 themeOf ICAM-1,express
R13238 T15373 T15372 themeOf ICAM-1,expression
R13239 T15390 T15388 themeOf responsible,regulates
R13240 T15391 T15389 themeOf responsible,regulates
R13241 T15392 T15395 themeOf ICAM-1,expression
R13242 T15393 T15394 themeOf TNF-α,expression
R13243 T15394 T15391 themeOf expression,responsible
R13244 T15374 T15376 themeOf expression,induced
R13245 T15395 T15390 themeOf expression,responsible
R13246 T15397 T15396 themeOf IκBα,degradation
R13247 T15375 T15374 themeOf ICAM-1,expression
R13248 T15379 T15377 themeOf expression,increased
R13249 T15380 T15378 themeOf expression,increased
R13250 T15400 T15399 themeOf p65,translocation
R13251 T15381 T15380 themeOf ICAM-1,expression
R13252 T15401 T15398 themeOf p50,translocation
R13253 T15402 T15399 locationOf nucleus,translocation
R13254 T15402 T15398 locationOf nucleus,translocation
R13255 T15382 T15379 themeOf LFA-3,expression
R13256 T15404 T15403 themeOf responsive,activation
R13257 T15405 T15404 themeOf luciferase,responsive
R13258 T15383 T15382 equivalentTo CD58,LFA-3
R13260 T15407 T15408 themeOf cdk4,expression
R13262 T15408 T15406 themeOf expression,suppressed
R13263 T15412 T15415 themeOf p21,expression
R13264 T15413 T15414 themeOf cdk4,expression
R13266 T15414 T15410 themeOf expression,effects
R13267 T15415 T15411 themeOf expression,effects
R13269 T15418 T15417 themeOf expression,higher
R13270 T15419 T15418 themeOf ICAM-1,expression
R13272 T15420 T15421 themeOf TNF-α,production
R13273 T15421 T15416 themeOf production,higher
R13274 T15422 T15425 themeOf higher,induce
R13276 T15423 T15422 themeOf expression,higher
R13277 T15424 T15423 themeOf ICAM-1,expression
R13280 T15427 T15428 themeOf ICAM-1,expression
R13281 T15428 T15426 themeOf expression,increased
R13284 T15432 T15433 themeOf TNF-α,expression
R13285 T15432 T15434 themeOf TNF-α,secretion
R13286 T15433 T15431 themeOf expression,stimulated
R13287 T15434 T15430 themeOf secretion,stimulated

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T15435 1290-1293 Protein denotes CGN
T15436 1281-1289 Protein_catabolism denotes degraded
T15437 2882-2885 Protein denotes MPO
T15438 3074-3077 Protein denotes TNF
T15439 3060-3070 Gene_expression denotes production
T15440 3171-3174 Protein denotes TNF
T15441 3157-3167 Gene_expression denotes production
T15442 3140-3147 Positive_regulation denotes induced
T15443 3343-3346 Protein denotes TNF
T15444 3335-3342 Gene_expression denotes produce
T15445 3563-3566 Protein denotes CGN
T15446 3545-3553 Protein_catabolism denotes degraded
T15447 3614-3617 Protein denotes TNF
T15448 3618-3626 Localization denotes secreted
T15449 3634-3641 Positive_regulation denotes induced
T15450 3680-3688 Localization denotes secreted
T15451 3781-3785 Protein denotes CD14
T15452 3790-3804 Protein denotes TLR4 receptors
T15453 3932-3936 Protein denotes CD14
T15454 3944-3953 Gene_expression denotes expressed
T15455 4146-4149 Protein denotes TNF
T15456 4150-4159 Localization denotes secretion
T15457 4138-4145 Positive_regulation denotes induced
T15458 4173-4176 Protein denotes TNF
T15459 4361-4364 Protein denotes TNF
T15460 4365-4373 Localization denotes secreted
T15461 4434-4441 Positive_regulation denotes induced
T15462 4509-4512 Protein denotes TNF
T15463 4513-4522 Localization denotes secretion
T15464 4679-4683 Protein denotes CD14
T15465 4729-4732 Protein denotes TNF
T15466 4733-4742 Localization denotes secretion
T15467 4706-4715 Negative_regulation denotes inhibited
T15468 4756-4760 Protein denotes TLR4
T15469 4825-4828 Protein denotes CGN
T15470 4895-4899 Protein denotes TLR4
T15471 4940-4949 Localization denotes secretion
T15472 4903-4912 Positive_regulation denotes activated
T15473 4991-4995 Protein denotes TLR4
T15474 5250-5256 Protein denotes ICAM-1
T15475 5214-5224 Gene_expression denotes expression
T15476 5261-5269 Positive_regulation denotes enhanced
T15477 5322-5328 Protein denotes ICAM-1
T15478 5308-5318 Gene_expression denotes expression
T15479 5496-5502 Protein denotes ICAM-1
T15480 5482-5492 Gene_expression denotes expression
T15481 5503-5510 Positive_regulation denotes induced
T15482 5904-5910 Protein denotes ICAM-1
T15483 5915-5920 Protein denotes LFA-3
T15484 5922-5926 Protein denotes CD58
T15485 5873-5882 Positive_regulation denotes increased
T15486 5883-5893 Gene_expression denotes expression
T15487 5883-5893 Gene_expression denotes expression
T15488 5883-5893 Gene_expression denotes expression
T15489 5873-5882 Positive_regulation denotes increased
T15490 5873-5882 Positive_regulation denotes increased
T15491 5873-5882 Positive_regulation denotes increased
T15492 6022-6025 Protein denotes CGN
T15493 6013-6021 Protein_catabolism denotes degraded
T15494 6275-6280 Protein denotes NF-κB
T15495 6321-6327 Protein denotes ICAM-1
T15496 6332-6337 Protein denotes TNF-α
T15497 6338-6348 Gene_expression denotes expression
T15498 6338-6348 Gene_expression denotes expression
T15499 6305-6316 Regulation denotes responsible
T15500 6305-6316 Regulation denotes responsible
T15501 6350-6355 Protein denotes NF-κB
T15502 6409-6430 Protein denotes inhibitor protein IκB
T15503 6356-6366 Positive_regulation denotes activation
T15504 6390-6401 Protein_catabolism denotes degradation
T15505 6356-6366 Positive_regulation denotes activation
T15506 6458-6463 Protein denotes NF-κB
T15507 6502-6506 Protein denotes IκBα
T15508 6525-6528 Protein denotes p65
T15509 6533-6536 Protein denotes p50
T15510 6586-6588 Protein denotes NF
T15511 6589-6591 Protein denotes κB
T15512 6603-6613 Protein denotes luciferase
T15513 6464-6474 Positive_regulation denotes activation
T15514 6487-6498 Protein_catabolism denotes degradation
T15515 6554-6561 Entity denotes nucleus
T15516 6569-6579 Positive_regulation denotes activation
T15517 6450-6457 Positive_regulation denotes induced
T15518 6508-6521 Localization denotes translocation
T15519 6508-6521 Localization denotes translocation
T15520 6508-6521 Localization denotes translocation
T15521 6569-6579 Positive_regulation denotes activation
T15522 6569-6579 Positive_regulation denotes activation
T15523 6569-6579 Positive_regulation denotes activation
T15524 6664-6669 Protein denotes NF-κB
T15525 6650-6660 Positive_regulation denotes activation
T15526 6674-6681 Positive_regulation denotes induced
T15527 6897-6902 Protein denotes NF-κB
T15528 6883-6893 Positive_regulation denotes activation
T15529 6875-6882 Positive_regulation denotes induced
T15530 6943-6948 Protein denotes NF-κB
T15531 7159-7164 Protein denotes NF-kB
T15532 7289-7294 Protein denotes NF-κB
T15533 7317-7321 Protein denotes cdk4
T15534 7295-7305 Positive_regulation denotes activation
T15535 7306-7316 Negative_regulation denotes suppressed
T15536 7322-7332 Gene_expression denotes expression
T15537 7343-7352 Positive_regulation denotes necessary
T15538 7393-7398 Protein denotes NF-κB
T15539 7506-7509 Protein denotes cdk
T15540 7520-7523 Protein denotes p21
T15541 7399-7409 Positive_regulation denotes activation
T15542 7553-7556 Protein denotes p21
T15543 7561-7565 Protein denotes cdk4
T15544 7566-7576 Gene_expression denotes expression
T15545 7566-7576 Gene_expression denotes expression
T15546 7794-7800 Protein denotes ICAM-1
T15547 7805-7810 Protein denotes TNF-α
T15548 7831-7836 Protein denotes NF-κB
T15549 7758-7768 Gene_expression denotes expression
T15550 7811-7821 Gene_expression denotes production
T15551 7811-7821 Gene_expression denotes production
T15552 7872-7878 Protein denotes ICAM-1
T15553 7858-7868 Gene_expression denotes expression
T15554 8720-8726 Protein denotes ICAM-1
T15555 8750-8756 Protein denotes ICAM-1
T15556 8813-8818 Protein denotes TNF-α
T15557 8727-8737 Gene_expression denotes expression
T15558 8819-8829 Gene_expression denotes expression
T15559 8710-8719 Positive_regulation denotes increased
T15560 8802-8812 Positive_regulation denotes stimulated
T15561 8928-8933 Protein denotes NF-κB
T15562 8934-8944 Positive_regulation denotes activation
R13259 T15435 T15436 themeOf CGN,degraded
R13261 T15438 T15439 themeOf TNF,production
R13265 T15440 T15441 themeOf TNF,production
R13268 T15441 T15442 themeOf production,induced
R13271 T15443 T15444 themeOf TNF,produce
R13275 T15445 T15446 themeOf CGN,degraded
R13278 T15447 T15448 themeOf TNF,secreted
R13279 T15447 T15450 themeOf TNF,secreted
R13282 T15448 T15449 themeOf secreted,induced
R13283 T15453 T15454 themeOf CD14,expressed
R13288 T15455 T15456 themeOf TNF,secretion
R13289 T15456 T15457 themeOf secretion,induced
R13290 T15459 T15460 themeOf TNF,secreted
R13291 T15460 T15461 themeOf secreted,induced
R13292 T15462 T15463 themeOf TNF,secretion
R13293 T15465 T15466 themeOf TNF,secretion
R13294 T15492 T15493 themeOf CGN,degraded
R13295 T15466 T15467 themeOf secretion,inhibited
R13296 T15495 T15497 themeOf ICAM-1,expression
R13297 T15470 T15471 themeOf TLR4,secretion
R13298 T15496 T15498 themeOf TNF-α,expression
R13299 T15497 T15499 themeOf expression,responsible
R13300 T15498 T15500 themeOf expression,responsible
R13301 T15501 T15503 themeOf NF-κB,activation
R13302 T15502 T15504 themeOf inhibitor protein IκB,degradation
R13303 T15471 T15472 themeOf secretion,activated
R13304 T15504 T15505 themeOf degradation,activation
R13305 T15474 T15475 themeOf ICAM-1,expression
R13306 T15506 T15513 themeOf NF-κB,activation
R13307 T15507 T15514 themeOf IκBα,degradation
R13308 T15507 T15518 themeOf IκBα,translocation
R13309 T15508 T15519 themeOf p65,translocation
R13310 T15509 T15520 themeOf p50,translocation
R13311 T15475 T15476 themeOf expression,enhanced
R13312 T15512 T15516 themeOf luciferase,activation
R13313 T15513 T15517 themeOf activation,induced
R13314 T15477 T15478 themeOf ICAM-1,expression
R13315 T15515 T15518 locationOf nucleus,translocation
R13316 T15515 T15519 locationOf nucleus,translocation
R13317 T15515 T15520 locationOf nucleus,translocation
R13318 T15518 T15521 themeOf translocation,activation
R13319 T15479 T15480 themeOf ICAM-1,expression
R13320 T15519 T15522 themeOf translocation,activation
R13321 T15520 T15523 themeOf translocation,activation
R13322 T15480 T15481 themeOf expression,induced
R13323 T15524 T15525 themeOf NF-κB,activation
R13324 T15482 T15485 themeOf ICAM-1,increased
R13325 T15525 T15526 themeOf activation,induced
R13326 T15527 T15528 themeOf NF-κB,activation
R13327 T15528 T15529 themeOf activation,induced
R13328 T15482 T15486 themeOf ICAM-1,expression
R13329 T15483 T15487 themeOf LFA-3,expression
R13330 T15532 T15534 themeOf NF-κB,activation
R13331 T15533 T15536 themeOf cdk4,expression
R13332 T15534 T15535 themeOf activation,suppressed
R13333 T15484 T15488 themeOf CD58,expression
R13334 T15536 T15537 themeOf expression,necessary
R13335 T15486 T15489 themeOf expression,increased
R13336 T15538 T15541 themeOf NF-κB,activation
R13337 T15487 T15490 themeOf expression,increased
R13338 T15542 T15544 themeOf p21,expression
R13339 T15543 T15545 themeOf cdk4,expression
R13340 T15488 T15491 themeOf expression,increased
R13341 T15546 T15549 themeOf ICAM-1,expression
R13342 T15546 T15550 themeOf ICAM-1,production
R13343 T15547 T15551 themeOf TNF-α,production
R13344 T15552 T15553 themeOf ICAM-1,expression
R13345 T15554 T15557 themeOf ICAM-1,expression
R13346 T15556 T15558 themeOf TNF-α,expression
R13347 T15557 T15559 themeOf expression,increased
R13348 T15558 T15560 themeOf expression,stimulated
R13349 T15561 T15562 themeOf NF-κB,activation

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T11468 3060-3070 Gene_expression denotes production
T11469 3074-3077 Protein denotes TNF
T11470 3106-3120 Positive_regulation denotes in response to
T11471 3140-3147 Positive_regulation denotes induced
T11472 3157-3167 Gene_expression denotes production
T11473 3171-3174 Protein denotes TNF
T11474 3335-3342 Gene_expression denotes produce
T11475 3343-3346 Protein denotes TNF
T11476 3614-3617 Protein denotes TNF
T11477 3618-3626 Localization denotes secreted
T11478 3634-3641 Positive_regulation denotes induced
T11479 3680-3688 Localization denotes secreted
T11480 3765-3773 Localization denotes presence
T11481 3765-3773 Localization denotes presence
T11482 3781-3785 Protein denotes CD14
T11483 3790-3804 Protein denotes TLR4 receptors
T11484 3878-3888 Gene_expression denotes expression
T11485 3878-3888 Gene_expression denotes expression
T11486 3932-3936 Protein denotes CD14
T11487 3944-3953 Gene_expression denotes expressed true
T11488 3984-3993 Gene_expression denotes expressed
T11489 4138-4145 Positive_regulation denotes induced
T11490 4146-4149 Protein denotes TNF
T11491 4150-4159 Localization denotes secretion
T11492 4173-4176 Protein denotes TNF
T11493 4177-4185 Regulation denotes response
T11494 4241-4249 Negative_regulation denotes decrease
T11495 4361-4364 Protein denotes TNF
T11496 4365-4373 Localization denotes secreted
T11497 4387-4394 Positive_regulation denotes induced
T11498 4509-4512 Protein denotes TNF
T11499 4513-4522 Localization denotes secretion
T11500 4706-4715 Negative_regulation denotes inhibited
T11501 4721-4728 Positive_regulation denotes induced
T11502 4729-4732 Protein denotes TNF
T11503 4733-4742 Localization denotes secretion
T11504 4756-4760 Protein denotes TLR4
T11505 4812-4820 Protein denotes receptor
T11506 4895-4899 Protein denotes TLR4
T11507 4903-4912 Positive_regulation denotes activated
T11508 4991-4995 Protein denotes TLR4
T11509 5214-5224 Gene_expression denotes expression
T11510 5232-5249 Protein denotes adhesion molecule
T11511 5250-5256 Protein denotes ICAM-1
T11512 5261-5269 Positive_regulation denotes enhanced
T11513 5308-5318 Gene_expression denotes expression
T11514 5322-5328 Protein denotes ICAM-1
T11515 5482-5492 Gene_expression denotes expression
T11516 5496-5502 Protein denotes ICAM-1
T11517 5503-5510 Positive_regulation denotes induced
T11518 5873-5882 Positive_regulation denotes increased
T11519 5873-5882 Positive_regulation denotes increased
T11520 5883-5893 Gene_expression denotes expression
T11521 5883-5893 Gene_expression denotes expression
T11522 5904-5910 Protein denotes ICAM-1
T11523 5915-5920 Protein denotes LFA-3
T11524 5922-5926 Protein denotes CD58
T11525 6060-6067 Gene_expression denotes express
T11526 6071-6080 Positive_regulation denotes increased
T11527 6091-6097 Protein denotes ICAM-1
T11528 6098-6116 Protein denotes adhesion molecules
T11529 6289-6298 Regulation denotes regulates
T11530 6289-6298 Regulation denotes regulates
T11531 6305-6316 Regulation denotes responsible
T11532 6305-6316 Regulation denotes responsible
T11533 6321-6327 Protein denotes ICAM-1
T11534 6332-6337 Protein denotes TNF-α
T11535 6338-6348 Gene_expression denotes expression
T11536 6338-6348 Gene_expression denotes expression
T11537 6487-6498 Protein_catabolism denotes degradation
T11538 6502-6506 Protein denotes IκBα
T11539 6508-6521 Localization denotes translocation
T11540 6508-6521 Localization denotes translocation
T11541 6525-6528 Protein denotes p65
T11542 6533-6536 Protein denotes p50
T11543 6554-6561 Entity denotes nucleus
T11544 6569-6579 Positive_regulation denotes activation
T11545 6592-6602 Regulation denotes responsive
T11546 6603-6613 Protein denotes luciferase
T11547 7306-7316 Negative_regulation denotes suppressed
T11548 7317-7321 Protein denotes cdk4
T11549 7322-7332 Gene_expression denotes expression
T11550 7520-7523 Protein denotes p21
T11551 7534-7541 Regulation denotes effects true
T11552 7534-7541 Regulation denotes effects true
T11553 7553-7556 Protein denotes p21
T11554 7561-7565 Protein denotes cdk4
T11555 7566-7576 Gene_expression denotes expression
T11556 7566-7576 Gene_expression denotes expression
T11557 7751-7757 Positive_regulation denotes higher
T11558 7751-7757 Positive_regulation denotes higher
T11559 7758-7768 Gene_expression denotes expression
T11560 7794-7800 Protein denotes ICAM-1
T11561 7805-7810 Protein denotes TNF-α
T11562 7811-7821 Gene_expression denotes production
T11563 7851-7857 Positive_regulation denotes higher
T11564 7858-7868 Gene_expression denotes expression
T11565 7872-7878 Protein denotes ICAM-1
T11566 8046-8052 Positive_regulation denotes induce
T11567 8710-8719 Positive_regulation denotes increased
T11568 8720-8726 Protein denotes ICAM-1
T11569 8727-8737 Gene_expression denotes expression
T11570 8750-8756 Protein denotes ICAM-1
T11571 8802-8812 Positive_regulation denotes stimulated
T11572 8802-8812 Positive_regulation denotes stimulated
T11573 8813-8818 Protein denotes TNF-α
T11574 8819-8829 Gene_expression denotes expression
T11575 8834-8843 Localization denotes secretion
R9722 T11469 T11468 themeOf TNF,production
R9729 T11482 T11480 themeOf CD14,presence
R9730 T11482 T11485 themeOf CD14,expression
R9731 T11483 T11481 themeOf TLR4 receptors,presence
R9732 T11483 T11484 themeOf TLR4 receptors,expression
R9733 T11486 T11487 themeOf CD14,expressed
R9734 T11486 T11488 themeOf CD14,expressed
R9735 T11490 T11491 themeOf TNF,secretion
R9736 T11491 T11489 themeOf secretion,induced
R9737 T11492 T11493 themeOf TNF,response
R9738 T11493 T11494 themeOf response,decrease
R9739 T11495 T11496 themeOf TNF,secreted
R9740 T11496 T11497 themeOf secreted,induced
R9741 T11498 T11499 themeOf TNF,secretion
R9742 T11501 T11500 themeOf induced,inhibited
R9743 T11502 T11503 themeOf TNF,secretion
R9744 T11503 T11501 themeOf secretion,induced
R9745 T11506 T11507 themeOf TLR4,activated
R9746 T11509 T11512 themeOf expression,enhanced
R9747 T11511 T11509 themeOf ICAM-1,expression
R9748 T11514 T11513 themeOf ICAM-1,expression
R9749 T11515 T11517 themeOf expression,induced
R9750 T11516 T11515 themeOf ICAM-1,expression
R9751 T11520 T11518 themeOf expression,increased
R9752 T11521 T11519 themeOf expression,increased
R9753 T11522 T11521 themeOf ICAM-1,expression
R9754 T11523 T11520 themeOf LFA-3,expression
R9755 T11524 T11523 equivalentTo CD58,LFA-3
R9756 T11525 T11526 themeOf express,increased
R9757 T11527 T11525 themeOf ICAM-1,express
R9758 T11531 T11529 themeOf responsible,regulates
R9759 T11532 T11530 themeOf responsible,regulates
R9760 T11533 T11536 themeOf ICAM-1,expression
R9761 T11534 T11535 themeOf TNF-α,expression
R9762 T11535 T11532 themeOf expression,responsible
R9763 T11536 T11531 themeOf expression,responsible
R9764 T11538 T11537 themeOf IκBα,degradation
R9765 T11541 T11540 themeOf p65,translocation
R9766 T11542 T11539 themeOf p50,translocation
R9767 T11543 T11540 locationOf nucleus,translocation
R9768 T11543 T11539 locationOf nucleus,translocation
R9769 T11545 T11544 themeOf responsive,activation
R9770 T11546 T11545 themeOf luciferase,responsive
R9771 T11548 T11549 themeOf cdk4,expression
R9772 T11549 T11547 themeOf expression,suppressed
R9773 T11553 T11556 themeOf p21,expression
R9774 T11554 T11555 themeOf cdk4,expression
R9775 T11555 T11551 themeOf expression,effects
R9776 T11556 T11552 themeOf expression,effects
R9777 T11559 T11558 themeOf expression,higher
R9778 T11560 T11559 themeOf ICAM-1,expression
R9779 T11561 T11562 themeOf TNF-α,production
R9780 T11562 T11557 themeOf production,higher
R9781 T11563 T11566 themeOf higher,induce
R9782 T11564 T11563 themeOf expression,higher
R9783 T11565 T11564 themeOf ICAM-1,expression
R9784 T11568 T11569 themeOf ICAM-1,expression
R9785 T11569 T11567 themeOf expression,increased
R9786 T11573 T11574 themeOf TNF-α,expression
R9787 T11573 T11575 themeOf TNF-α,secretion
R9788 T11574 T11572 themeOf expression,stimulated
R9789 T11575 T11571 themeOf secretion,stimulated
R9721 T11468 T11470 themeOf production,in response to
R9723 T11472 T11471 themeOf production,induced
R9724 T11473 T11472 themeOf TNF,production
R9725 T11475 T11474 themeOf TNF,produce
R9726 T11476 T11477 themeOf TNF,secreted
R9727 T11476 T11479 themeOf TNF,secreted
R9728 T11477 T11478 themeOf secreted,induced

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T13234 157-161 P00519 denotes able
T13235 756-760 P00519 denotes able
T13236 3074-3077 P01375 denotes TNF
T13237 3171-3174 P01375 denotes TNF
T13238 3343-3346 P01375 denotes TNF
T13239 3614-3617 P01375 denotes TNF
T13240 3781-3785 P08571 denotes CD14
T13241 3790-3794 O00206 denotes TLR4
T13242 3932-3936 P08571 denotes CD14
T13243 4146-4149 P01375 denotes TNF
T13244 4173-4176 P01375 denotes TNF
T13245 4361-4364 P01375 denotes TNF
T13246 4509-4512 P01375 denotes TNF
T13247 4679-4683 P08571 denotes CD14
T13248 4729-4732 P01375 denotes TNF
T13249 4756-4760 O00206 denotes TLR4
T13250 4895-4899 O00206 denotes TLR4
T13251 4991-4995 O00206 denotes TLR4
T13252 5250-5256 P05362 denotes ICAM-1
T13253 5322-5328 P05362 denotes ICAM-1
T13254 5496-5502 P05362 denotes ICAM-1
T13255 5904-5910 P05362 denotes ICAM-1
T13256 5922-5926 P19256 denotes CD58
T13257 6091-6097 P05362 denotes ICAM-1
T13258 6321-6327 P05362 denotes ICAM-1
T13259 6332-6335 P01375 denotes TNF
T13260 6332-6337 P01375 denotes TNF-α
T13261 6502-6506 P25963 denotes IκBα
T13262 6525-6528 Q04206 denotes p65
T13263 6525-6528 P21579 denotes p65
T13264 6533-6536 P19838 denotes p50
T13265 6603-6613 P08659 denotes luciferase
T13266 7794-7800 P05362 denotes ICAM-1
T13267 7805-7808 P01375 denotes TNF
T13268 7805-7810 P01375 denotes TNF-α
T13269 7872-7878 P05362 denotes ICAM-1
T13270 8720-8726 P05362 denotes ICAM-1
T13271 8750-8756 P05362 denotes ICAM-1
T13272 8813-8816 P01375 denotes TNF
T13273 8813-8818 P01375 denotes TNF-α

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T11353 3060-3070 Gene_expression denotes production
T11354 3074-3077 Protein denotes TNF
T11355 3140-3147 Positive_regulation denotes induced
T11356 3157-3167 Gene_expression denotes production
T11357 3171-3174 Protein denotes TNF
T11358 3335-3342 Gene_expression denotes produce
T11359 3343-3346 Protein denotes TNF
T11360 3385-3392 Positive_regulation denotes induced
T11361 3614-3617 Protein denotes TNF
T11362 3618-3626 Localization denotes secreted
T11363 3634-3641 Positive_regulation denotes induced
T11364 3680-3688 Localization denotes secreted
T11365 3745-3755 Binding denotes associated true
T11366 3781-3785 Protein denotes CD14
T11367 3790-3804 Protein denotes TLR4 receptors
T11368 3932-3936 Protein denotes CD14
T11369 3944-3953 Gene_expression denotes expressed
T11370 3984-3993 Gene_expression denotes expressed
T11371 4138-4145 Positive_regulation denotes induced
T11372 4146-4149 Protein denotes TNF
T11373 4150-4159 Localization denotes secretion
T11374 4173-4176 Protein denotes TNF
T11375 4241-4249 Negative_regulation denotes decrease
T11376 4361-4364 Protein denotes TNF
T11377 4365-4373 Localization denotes secreted
T11378 4387-4394 Positive_regulation denotes induced
T11379 4434-4441 Positive_regulation denotes induced
T11380 4509-4512 Protein denotes TNF
T11381 4513-4522 Localization denotes secretion
T11382 4706-4715 Negative_regulation denotes inhibited
T11383 4721-4728 Positive_regulation denotes induced
T11384 4729-4732 Protein denotes TNF
T11385 4733-4742 Localization denotes secretion
T11386 4756-4760 Protein denotes TLR4
T11387 4812-4820 Protein denotes receptor
T11388 4895-4899 Protein denotes TLR4
T11389 4903-4912 Positive_regulation denotes activated
T11390 4940-4949 Localization denotes secretion
T11391 4991-4995 Protein denotes TLR4
T11392 5214-5224 Gene_expression denotes expression
T11393 5232-5249 Protein denotes adhesion molecule
T11394 5250-5256 Protein denotes ICAM-1
T11395 5261-5269 Positive_regulation denotes enhanced
T11396 5308-5318 Gene_expression denotes expression
T11397 5322-5328 Protein denotes ICAM-1
T11398 5482-5492 Gene_expression denotes expression
T11399 5496-5502 Protein denotes ICAM-1
T11400 5503-5510 Positive_regulation denotes induced
T11401 5873-5882 Positive_regulation denotes increased
T11402 5883-5893 Gene_expression denotes expression true
T11403 5904-5910 Protein denotes ICAM-1
T11404 5915-5920 Protein denotes LFA-3 true
T11405 5922-5926 Protein denotes CD58
T11406 6060-6067 Gene_expression denotes express
T11407 6071-6080 Positive_regulation denotes increased
T11408 6091-6097 Protein denotes ICAM-1
T11409 6098-6116 Protein denotes adhesion molecules
T11410 6289-6298 Regulation denotes regulates
T11411 6305-6316 Regulation denotes responsible
T11412 6321-6327 Protein denotes ICAM-1
T11413 6332-6337 Protein denotes TNF-α
T11414 6338-6348 Gene_expression denotes expression
T11415 6487-6498 Protein_catabolism denotes degradation
T11416 6502-6506 Protein denotes IκBα
T11417 6508-6521 Localization denotes translocation
T11418 6525-6528 Protein denotes p65
T11419 6533-6536 Protein denotes p50
T11420 6554-6561 Entity denotes nucleus
T11421 6569-6579 Positive_regulation denotes activation
T11422 6603-6613 Protein denotes luciferase
T11423 7306-7316 Negative_regulation denotes suppressed
T11424 7317-7321 Protein denotes cdk4
T11425 7322-7332 Gene_expression denotes expression
T11426 7520-7523 Protein denotes p21
T11427 7553-7556 Protein denotes p21
T11428 7561-7565 Protein denotes cdk4
T11429 7566-7576 Gene_expression denotes expression
T11430 7758-7768 Gene_expression denotes expression
T11431 7794-7800 Protein denotes ICAM-1
T11432 7805-7810 Protein denotes TNF-α
T11433 7811-7821 Gene_expression denotes production
T11434 7858-7868 Gene_expression denotes expression
T11435 7872-7878 Protein denotes ICAM-1
T11436 8710-8719 Positive_regulation denotes increased
T11437 8720-8726 Protein denotes ICAM-1
T11438 8727-8737 Gene_expression denotes expression
T11439 8739-8749 Positive_regulation denotes stimulated
T11440 8750-8756 Protein denotes ICAM-1
T11441 8802-8812 Positive_regulation denotes stimulated
T11442 8813-8818 Protein denotes TNF-α
T11443 8819-8829 Gene_expression denotes expression
T11444 8834-8843 Localization denotes secretion
R9663 T11354 T11353 themeOf TNF,production
R9664 T11356 T11355 themeOf production,induced
R9665 T11357 T11356 themeOf TNF,production
R9666 T11359 T11358 themeOf TNF,produce
R9667 T11361 T11362 themeOf TNF,secreted
R9668 T11361 T11364 themeOf TNF,secreted
R9669 T11362 T11363 themeOf secreted,induced
R9670 T11366 T11365 themeOf CD14,associated
R9671 T11367 T11365 themeOf TLR4 receptors,associated
R9672 T11368 T11370 themeOf CD14,expressed
R9673 T11368 T11369 themeOf CD14,expressed
R9674 T11372 T11373 themeOf TNF,secretion
R9675 T11373 T11371 themeOf secretion,induced
R9676 T11376 T11377 themeOf TNF,secreted
R9677 T11377 T11378 themeOf secreted,induced
R9678 T11377 T11379 themeOf secreted,induced
R9679 T11378 T11379 themeOf induced,induced
R9680 T11380 T11381 themeOf TNF,secretion
R9681 T11383 T11382 themeOf induced,inhibited
R9682 T11384 T11385 themeOf TNF,secretion
R9683 T11385 T11383 themeOf secretion,induced
R9684 T11388 T11390 themeOf TLR4,secretion
R9685 T11388 T11389 themeOf TLR4,activated
R9686 T11392 T11395 themeOf expression,enhanced
R9687 T11393 T11392 themeOf adhesion molecule,expression
R9688 T11394 T11392 themeOf ICAM-1,expression
R9689 T11397 T11396 themeOf ICAM-1,expression
R9690 T11398 T11400 themeOf expression,induced
R9691 T11399 T11398 themeOf ICAM-1,expression
R9692 T11402 T11401 themeOf expression,increased
R9693 T11403 T11402 themeOf ICAM-1,expression
R9694 T11404 T11402 themeOf LFA-3,expression
R9695 T11405 T11404 equivalentTo CD58,LFA-3
R9696 T11406 T11407 themeOf express,increased
R9697 T11408 T11409 themeOf ICAM-1,adhesion molecules
R9698 T11408 T11406 themeOf ICAM-1,express
R9699 T11408 T11407 themeOf ICAM-1,increased
R9700 T11409 T11407 themeOf adhesion molecules,increased
R9701 T11411 T11410 themeOf responsible,regulates
R9702 T11412 T11414 themeOf ICAM-1,expression
R9703 T11413 T11414 themeOf TNF-α,expression
R9704 T11414 T11411 themeOf expression,responsible
R9705 T11416 T11415 themeOf IκBα,degradation
R9706 T11418 T11417 themeOf p65,translocation
R9707 T11419 T11417 themeOf p50,translocation
R9708 T11420 T11417 locationOf nucleus,translocation
R9709 T11424 T11425 themeOf cdk4,expression
R9710 T11425 T11423 themeOf expression,suppressed
R9711 T11427 T11429 themeOf p21,expression
R9712 T11428 T11429 themeOf cdk4,expression
R9713 T11431 T11433 themeOf ICAM-1,production
R9714 T11432 T11433 themeOf TNF-α,production
R9715 T11435 T11434 themeOf ICAM-1,expression
R9716 T11437 T11438 themeOf ICAM-1,expression
R9717 T11438 T11436 themeOf expression,increased
R9718 T11442 T11443 themeOf TNF-α,expression
R9719 T11443 T11441 themeOf expression,stimulated
R9720 T11444 T11441 themeOf secretion,stimulated