PMC:2792620 / 38631-39188 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2792620","sourcedb":"PMC","sourceid":"2792620","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2792620","text":"iNOS-2 Inhibitors\nSince the upregulation of iNOS-2 is harmful to neurons, its inhibition might have a neuroprotective effect. Although an unregulated level of NO can cause neuronal degeneration via apoptosis, a small amount of NO could inhibit apoptosis. Survival of serum deprived pheochromocytoma PC-12 cells was observed when treated with an NO donor. These results indicate that the cytoprotective effect of nipradilol in PC12 cell death was due to the caspase-3 inhibition mediated by NO-related S-nitrosylation and activation of protein kinase G.[109]","divisions":[{"label":"Title","span":{"begin":0,"end":17}}],"tracks":[{"project":"2_test","denotations":[{"id":"20040958-12359266-47224512","span":{"begin":553,"end":556},"obj":"12359266"},{"id":"T89481","span":{"begin":553,"end":556},"obj":"12359266"}],"attributes":[{"subj":"20040958-12359266-47224512","pred":"source","obj":"2_test"},{"subj":"T89481","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecd3","default":true}]}]}}