PMC:2792620 / 27403-29120
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2792620","sourcedb":"PMC","sourceid":"2792620","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2792620","text":"Travaprost\nTravaprost is a synthetic prostaglandin F 2a analogue. Its chemical name is isopropyl (Z)-7- [(1 R,2 R,3 R,5 S)-3,5-dihydroxy-2-[(1 E,3 R)-3-hydroxy-4-[(a,a,a-trifluoro- m -tolyl)oxy]-1- butenyl]cyclopentyl]-5-heptenoate. Following absorption into the eye, the free acid form of travaprost interacts with the endogenous FP prostanoid receptor, to enhance aqueous humor outflow and lower intraocular pressure (IOP). It differs from other PGAs, which exhibit partial agonist activity, in that it is a full agonist at the PGF2a receptor.[78]\nIn clinical studies, travaprost once daily produced reductions in IOP of between 7-8 mmHg, from a mean baseline IOP of 25-27 mmHg, an effect similar to that noted in the case of bimatoprost or latanoprost.[79] In controlled clinical trials, travaprost 0.004% once daily, used as monotherapy, produced greater IOP reduction than timolol 0.5% b.i.d and equal or greater reduction than latanoprost 0.005%.[80]\nTravaprost 0.004% was also shown to be an effective adjunctive agent, offering an additional 5 - 7 mmHg IOP reduction in patients inadequately controlled on timolol 0.5%. In trial, it was observed that travaprost monotherapy had better lowering than dorzolamide 2.0% timolol maleate 0.5% fixed combination.[81]\nTravaprost provides robust lowering of IOP with little diurnal fluctuation and results in low target pressures in a large percentage of the patients.[82] It is very stable compound, to be applied once daily in the evening. It does not require refrigeration and protection from sunlight.[83]\nMacular oedema, including cystoid macular oedema, is cited as a warning in the US product labeling for travaprost, as it is for other prostaglandin analogues.","divisions":[{"label":"Title","span":{"begin":0,"end":10}}],"tracks":[{"project":"2_test","denotations":[{"id":"20040958-11765147-47224491","span":{"begin":546,"end":548},"obj":"11765147"},{"id":"20040958-11589866-47224492","span":{"begin":756,"end":758},"obj":"11589866"},{"id":"20040958-17073898-47224493","span":{"begin":953,"end":955},"obj":"17073898"},{"id":"20040958-16968583-47224494","span":{"begin":1264,"end":1266},"obj":"16968583"},{"id":"20040958-14996520-47224495","span":{"begin":1418,"end":1420},"obj":"14996520"},{"id":"20040958-12083996-47224496","span":{"begin":1555,"end":1557},"obj":"12083996"},{"id":"T84745","span":{"begin":546,"end":548},"obj":"11765147"},{"id":"T79208","span":{"begin":756,"end":758},"obj":"11589866"},{"id":"T90413","span":{"begin":953,"end":955},"obj":"17073898"},{"id":"T4026","span":{"begin":1264,"end":1266},"obj":"16968583"},{"id":"T73653","span":{"begin":1418,"end":1420},"obj":"14996520"},{"id":"T70436","span":{"begin":1555,"end":1557},"obj":"12083996"}],"attributes":[{"subj":"20040958-11765147-47224491","pred":"source","obj":"2_test"},{"subj":"20040958-11589866-47224492","pred":"source","obj":"2_test"},{"subj":"20040958-17073898-47224493","pred":"source","obj":"2_test"},{"subj":"20040958-16968583-47224494","pred":"source","obj":"2_test"},{"subj":"20040958-14996520-47224495","pred":"source","obj":"2_test"},{"subj":"20040958-12083996-47224496","pred":"source","obj":"2_test"},{"subj":"T84745","pred":"source","obj":"2_test"},{"subj":"T79208","pred":"source","obj":"2_test"},{"subj":"T90413","pred":"source","obj":"2_test"},{"subj":"T4026","pred":"source","obj":"2_test"},{"subj":"T73653","pred":"source","obj":"2_test"},{"subj":"T70436","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecc8","default":true}]}]}}