PMC:2791889 / 6836-7111
Annnotations
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T3530","span":{"begin":35,"end":40},"obj":"P22301"},{"id":"T3531","span":{"begin":91,"end":96},"obj":"P22301"},{"id":"T3532","span":{"begin":163,"end":168},"obj":"P29459"},{"id":"T3533","span":{"begin":163,"end":168},"obj":"P29460"},{"id":"T3534","span":{"begin":188,"end":191},"obj":"P01730"},{"id":"T3535","span":{"begin":269,"end":274},"obj":"P29460"},{"id":"T3536","span":{"begin":269,"end":274},"obj":"P29459"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
bionlp-st-ge-2016-reference
{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T2891","span":{"begin":27,"end":31},"obj":"Negative_regulation"},{"id":"T2892","span":{"begin":35,"end":40},"obj":"Protein"},{"id":"T2893","span":{"begin":41,"end":49},"obj":"Gene_expression"},{"id":"T2894","span":{"begin":63,"end":71},"obj":"Positive_regulation"},{"id":"T2895","span":{"begin":77,"end":87},"obj":"Negative_regulation"},{"id":"T2896","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T2897","span":{"begin":97,"end":107},"obj":"Gene_expression"},{"id":"T2898","span":{"begin":163,"end":168},"obj":"Protein"},{"id":"T2899","span":{"begin":188,"end":191},"obj":"Protein"},{"id":"T2900","span":{"begin":269,"end":274},"obj":"Protein"}],"relations":[{"id":"R2157","pred":"themeOf","subj":"T2897","obj":"T2895"},{"id":"R2152","pred":"themeOf","subj":"T2891","obj":"T2894"},{"id":"R2153","pred":"themeOf","subj":"T2892","obj":"T2891"},{"id":"R2154","pred":"themeOf","subj":"T2892","obj":"T2893"},{"id":"R2155","pred":"causeOf","subj":"T2895","obj":"T2894"},{"id":"R2156","pred":"themeOf","subj":"T2896","obj":"T2897"}],"attributes":[{"id":"M30","pred":"Speculation","subj":"T2894","obj":"true"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
pmc-enju-pas
{"project":"pmc-enju-pas","denotations":[{"id":"T3139","span":{"begin":0,"end":2},"obj":"TO"},{"id":"T3140","span":{"begin":3,"end":14},"obj":"VB"},{"id":"T3141","span":{"begin":15,"end":22},"obj":"IN"},{"id":"T3142","span":{"begin":23,"end":26},"obj":"DT"},{"id":"T3143","span":{"begin":27,"end":31},"obj":"NN"},{"id":"T3144","span":{"begin":32,"end":34},"obj":"IN"},{"id":"T3145","span":{"begin":35,"end":40},"obj":"NN"},{"id":"T3146","span":{"begin":41,"end":49},"obj":"VB"},{"id":"T3147","span":{"begin":50,"end":52},"obj":"IN"},{"id":"T3148","span":{"begin":53,"end":56},"obj":"NN"},{"id":"T3149","span":{"begin":57,"end":62},"obj":"NN"},{"id":"T3150","span":{"begin":63,"end":71},"obj":"VB"},{"id":"T3151","span":{"begin":72,"end":76},"obj":"IN"},{"id":"T3152","span":{"begin":77,"end":87},"obj":"NN"},{"id":"T3153","span":{"begin":88,"end":90},"obj":"IN"},{"id":"T3154","span":{"begin":91,"end":96},"obj":"NN"},{"id":"T3155","span":{"begin":97,"end":107},"obj":"NN"},{"id":"T3156","span":{"begin":108,"end":110},"obj":"IN"},{"id":"T3157","span":{"begin":111,"end":114},"obj":"NN"},{"id":"T3158","span":{"begin":115,"end":118},"obj":"CC"},{"id":"T3159","span":{"begin":119,"end":123},"obj":"JJ"},{"id":"T3160","span":{"begin":124,"end":131},"obj":"NN"},{"id":"T3161","span":{"begin":132,"end":136},"obj":"NN"},{"id":"T3162","span":{"begin":137,"end":139},"obj":"CC"},{"id":"T3163","span":{"begin":140,"end":153},"obj":"RB"},{"id":"T3164","span":{"begin":154,"end":162},"obj":"VB"},{"id":"T3165","span":{"begin":163,"end":168},"obj":"NN"},{"id":"T3166","span":{"begin":168,"end":169},"obj":"-COMMA-"},{"id":"T3167","span":{"begin":170,"end":172},"obj":"PRP"},{"id":"T3168","span":{"begin":173,"end":181},"obj":"VB"},{"id":"T3169","span":{"begin":182,"end":187},"obj":"JJ"},{"id":"T3170","span":{"begin":188,"end":192},"obj":"JJ"},{"id":"T3171","span":{"begin":193,"end":200},"obj":"NN"},{"id":"T3172","span":{"begin":201,"end":205},"obj":"IN"},{"id":"T3173","span":{"begin":206,"end":216},"obj":"VB"},{"id":"T3174","span":{"begin":217,"end":222},"obj":"NN"},{"id":"T3175","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T3176","span":{"begin":226,"end":233},"obj":"NN"},{"id":"T3177","span":{"begin":234,"end":243},"obj":"VB"},{"id":"T3178","span":{"begin":244,"end":246},"obj":"IN"},{"id":"T3179","span":{"begin":247,"end":249},"obj":"NN"},{"id":"T3180","span":{"begin":250,"end":252},"obj":"IN"},{"id":"T3181","span":{"begin":253,"end":256},"obj":"DT"},{"id":"T3182","span":{"begin":257,"end":265},"obj":"NN"},{"id":"T3183","span":{"begin":266,"end":268},"obj":"IN"},{"id":"T3184","span":{"begin":269,"end":274},"obj":"NN"}],"relations":[{"id":"R2357","pred":"arg1Of","subj":"T3140","obj":"T3139"},{"id":"R2358","pred":"arg1Of","subj":"T3143","obj":"T3142"},{"id":"R2359","pred":"arg1Of","subj":"T3143","obj":"T3144"},{"id":"R2360","pred":"arg1Of","subj":"T3143","obj":"T3150"},{"id":"R2361","pred":"arg2Of","subj":"T3145","obj":"T3144"},{"id":"R2362","pred":"arg2Of","subj":"T3145","obj":"T3146"},{"id":"R2363","pred":"arg1Of","subj":"T3149","obj":"T3146"},{"id":"R2364","pred":"arg2Of","subj":"T3149","obj":"T3147"},{"id":"R2365","pred":"arg1Of","subj":"T3149","obj":"T3148"},{"id":"R2366","pred":"arg2Of","subj":"T3150","obj":"T3140"},{"id":"R2367","pred":"arg1Of","subj":"T3150","obj":"T3141"},{"id":"R2368","pred":"arg1Of","subj":"T3150","obj":"T3151"},{"id":"R2369","pred":"arg1Of","subj":"T3152","obj":"T3153"},{"id":"R2370","pred":"arg1Of","subj":"T3152","obj":"T3158"},{"id":"R2371","pred":"arg2Of","subj":"T3155","obj":"T3153"},{"id":"R2372","pred":"arg1Of","subj":"T3155","obj":"T3154"},{"id":"R2373","pred":"arg1Of","subj":"T3155","obj":"T3156"},{"id":"R2374","pred":"arg2Of","subj":"T3157","obj":"T3156"},{"id":"R2375","pred":"arg2Of","subj":"T3158","obj":"T3151"},{"id":"R2376","pred":"arg1Of","subj":"T3161","obj":"T3159"},{"id":"R2377","pred":"arg1Of","subj":"T3161","obj":"T3160"},{"id":"R2378","pred":"arg1Of","subj":"T3161","obj":"T3162"},{"id":"R2379","pred":"arg2Of","subj":"T3162","obj":"T3158"},{"id":"R2380","pred":"arg2Of","subj":"T3165","obj":"T3162"},{"id":"R2381","pred":"arg1Of","subj":"T3165","obj":"T3163"},{"id":"R2382","pred":"arg2Of","subj":"T3165","obj":"T3164"},{"id":"R2383","pred":"arg1Of","subj":"T3167","obj":"T3140"},{"id":"R2384","pred":"arg1Of","subj":"T3167","obj":"T3168"},{"id":"R2385","pred":"modOf","subj":"T3168","obj":"T3139"},{"id":"R2386","pred":"arg1Of","subj":"T3168","obj":"T3166"},{"id":"R2387","pred":"arg2Of","subj":"T3171","obj":"T3168"},{"id":"R2388","pred":"arg1Of","subj":"T3171","obj":"T3169"},{"id":"R2389","pred":"arg1Of","subj":"T3171","obj":"T3170"},{"id":"R2390","pred":"arg1Of","subj":"T3171","obj":"T3172"},{"id":"R2391","pred":"arg2Of","subj":"T3174","obj":"T3172"},{"id":"R2392","pred":"arg1Of","subj":"T3174","obj":"T3173"},{"id":"R2393","pred":"arg1Of","subj":"T3174","obj":"T3175"},{"id":"R2394","pred":"arg2Of","subj":"T3174","obj":"T3177"},{"id":"R2395","pred":"arg2Of","subj":"T3176","obj":"T3175"},{"id":"R2396","pred":"arg1Of","subj":"T3177","obj":"T3180"},{"id":"R2397","pred":"arg1Of","subj":"T3179","obj":"T3177"},{"id":"R2398","pred":"arg2Of","subj":"T3179","obj":"T3178"},{"id":"R2399","pred":"arg2Of","subj":"T3182","obj":"T3180"},{"id":"R2400","pred":"arg1Of","subj":"T3182","obj":"T3181"},{"id":"R2401","pred":"arg1Of","subj":"T3182","obj":"T3183"},{"id":"R2402","pred":"arg2Of","subj":"T3184","obj":"T3183"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
bionlp-st-ge-2016-spacy-parsed
{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T3749","span":{"begin":0,"end":2},"obj":"TO"},{"id":"T3750","span":{"begin":3,"end":14},"obj":"VB"},{"id":"T3751","span":{"begin":15,"end":22},"obj":"IN"},{"id":"T3752","span":{"begin":23,"end":26},"obj":"DT"},{"id":"T3753","span":{"begin":27,"end":31},"obj":"NN"},{"id":"T3754","span":{"begin":32,"end":34},"obj":"IN"},{"id":"T3755","span":{"begin":35,"end":40},"obj":"NN"},{"id":"T3756","span":{"begin":41,"end":49},"obj":"VBN"},{"id":"T3757","span":{"begin":50,"end":52},"obj":"IN"},{"id":"T3758","span":{"begin":53,"end":56},"obj":"JJ"},{"id":"T3759","span":{"begin":57,"end":62},"obj":"NNS"},{"id":"T3760","span":{"begin":63,"end":71},"obj":"VBD"},{"id":"T3761","span":{"begin":72,"end":76},"obj":"IN"},{"id":"T3762","span":{"begin":77,"end":87},"obj":"NN"},{"id":"T3763","span":{"begin":88,"end":90},"obj":"IN"},{"id":"T3764","span":{"begin":91,"end":96},"obj":"JJ"},{"id":"T3765","span":{"begin":97,"end":107},"obj":"NN"},{"id":"T3766","span":{"begin":108,"end":110},"obj":"IN"},{"id":"T3767","span":{"begin":111,"end":114},"obj":"NNP"},{"id":"T3768","span":{"begin":115,"end":118},"obj":"CC"},{"id":"T3769","span":{"begin":119,"end":123},"obj":"JJ"},{"id":"T3770","span":{"begin":124,"end":131},"obj":"NN"},{"id":"T3771","span":{"begin":132,"end":136},"obj":"NN"},{"id":"T3772","span":{"begin":137,"end":139},"obj":"CC"},{"id":"T3773","span":{"begin":140,"end":153},"obj":"RB"},{"id":"T3774","span":{"begin":154,"end":162},"obj":"VBN"},{"id":"T3775","span":{"begin":163,"end":168},"obj":"NN"},{"id":"T3776","span":{"begin":168,"end":169},"obj":","},{"id":"T3777","span":{"begin":170,"end":172},"obj":"PRP"},{"id":"T3778","span":{"begin":173,"end":181},"obj":"VBD"},{"id":"T3779","span":{"begin":182,"end":187},"obj":"JJ"},{"id":"T3780","span":{"begin":188,"end":191},"obj":"NNP"},{"id":"T3781","span":{"begin":191,"end":192},"obj":"CD"},{"id":"T3782","span":{"begin":193,"end":194},"obj":"NNP"},{"id":"T3783","span":{"begin":195,"end":200},"obj":"NNS"},{"id":"T3784","span":{"begin":201,"end":205},"obj":"IN"},{"id":"T3785","span":{"begin":206,"end":216},"obj":"VBG"},{"id":"T3786","span":{"begin":217,"end":222},"obj":"NNS"},{"id":"T3787","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T3788","span":{"begin":226,"end":233},"obj":"NN"},{"id":"T3789","span":{"begin":234,"end":243},"obj":"VBN"},{"id":"T3790","span":{"begin":244,"end":246},"obj":"IN"},{"id":"T3791","span":{"begin":247,"end":249},"obj":"NNP"},{"id":"T3792","span":{"begin":250,"end":252},"obj":"IN"},{"id":"T3793","span":{"begin":253,"end":256},"obj":"DT"},{"id":"T3794","span":{"begin":257,"end":265},"obj":"NN"},{"id":"T3795","span":{"begin":266,"end":268},"obj":"IN"},{"id":"T3796","span":{"begin":269,"end":274},"obj":"NN"},{"id":"T3797","span":{"begin":274,"end":275},"obj":"."}],"relations":[{"id":"R2901","pred":"aux","subj":"T3749","obj":"T3750"},{"id":"R2902","pred":"advcl","subj":"T3750","obj":"T3778"},{"id":"R2903","pred":"mark","subj":"T3751","obj":"T3760"},{"id":"R2904","pred":"det","subj":"T3752","obj":"T3753"},{"id":"R2905","pred":"nsubj","subj":"T3753","obj":"T3760"},{"id":"R2906","pred":"prep","subj":"T3754","obj":"T3753"},{"id":"R2907","pred":"pobj","subj":"T3755","obj":"T3754"},{"id":"R2908","pred":"acl","subj":"T3756","obj":"T3755"},{"id":"R2909","pred":"agent","subj":"T3757","obj":"T3756"},{"id":"R2910","pred":"amod","subj":"T3758","obj":"T3759"},{"id":"R2911","pred":"pobj","subj":"T3759","obj":"T3757"},{"id":"R2912","pred":"ccomp","subj":"T3760","obj":"T3750"},{"id":"R2913","pred":"prep","subj":"T3761","obj":"T3760"},{"id":"R2914","pred":"pobj","subj":"T3762","obj":"T3761"},{"id":"R2915","pred":"prep","subj":"T3763","obj":"T3762"},{"id":"R2916","pred":"compound","subj":"T3764","obj":"T3765"},{"id":"R2917","pred":"pobj","subj":"T3765","obj":"T3763"},{"id":"R2918","pred":"prep","subj":"T3766","obj":"T3765"},{"id":"R2919","pred":"pobj","subj":"T3767","obj":"T3766"},{"id":"R2920","pred":"cc","subj":"T3768","obj":"T3767"},{"id":"R2921","pred":"amod","subj":"T3769","obj":"T3770"},{"id":"R2922","pred":"compound","subj":"T3770","obj":"T3771"},{"id":"R2923","pred":"conj","subj":"T3771","obj":"T3765"},{"id":"R2924","pred":"cc","subj":"T3772","obj":"T3760"},{"id":"R2925","pred":"advmod","subj":"T3773","obj":"T3774"},{"id":"R2926","pred":"conj","subj":"T3774","obj":"T3760"},{"id":"R2927","pred":"dobj","subj":"T3775","obj":"T3774"},{"id":"R2928","pred":"punct","subj":"T3776","obj":"T3778"},{"id":"R2929","pred":"nsubj","subj":"T3777","obj":"T3778"},{"id":"R2930","pred":"ROOT","subj":"T3778","obj":"T3778"},{"id":"R2931","pred":"amod","subj":"T3779","obj":"T3783"},{"id":"R2932","pred":"compound","subj":"T3780","obj":"T3783"},{"id":"R2933","pred":"nummod","subj":"T3781","obj":"T3783"},{"id":"R2934","pred":"compound","subj":"T3782","obj":"T3783"},{"id":"R2935","pred":"dobj","subj":"T3783","obj":"T3778"},{"id":"R2936","pred":"prep","subj":"T3784","obj":"T3778"},{"id":"R2937","pred":"amod","subj":"T3785","obj":"T3786"},{"id":"R2938","pred":"pobj","subj":"T3786","obj":"T3784"},{"id":"R2939","pred":"prep","subj":"T3787","obj":"T3786"},{"id":"R2940","pred":"pobj","subj":"T3788","obj":"T3787"},{"id":"R2941","pred":"acl","subj":"T3789","obj":"T3788"},{"id":"R2942","pred":"agent","subj":"T3790","obj":"T3789"},{"id":"R2943","pred":"pobj","subj":"T3791","obj":"T3790"},{"id":"R2944","pred":"prep","subj":"T3792","obj":"T3789"},{"id":"R2945","pred":"det","subj":"T3793","obj":"T3794"},{"id":"R2946","pred":"pobj","subj":"T3794","obj":"T3792"},{"id":"R2947","pred":"prep","subj":"T3795","obj":"T3794"},{"id":"R2948","pred":"pobj","subj":"T3796","obj":"T3795"},{"id":"R2949","pred":"punct","subj":"T3797","obj":"T3778"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T4168","span":{"begin":91,"end":107},"obj":"http://purl.obolibrary.org/obo/GO_0032653"},{"id":"T4172","span":{"begin":91,"end":107},"obj":"http://purl.obolibrary.org/obo/GO_0032613"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T4180","span":{"begin":163,"end":168},"obj":"http://purl.obolibrary.org/obo/GO_0005143"},{"id":"T4181","span":{"begin":269,"end":274},"obj":"http://purl.obolibrary.org/obo/GO_0005143"},{"id":"T4194","span":{"begin":35,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T4195","span":{"begin":91,"end":96},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T4221","span":{"begin":57,"end":62},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4222","span":{"begin":195,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
sentences
{"project":"sentences","denotations":[{"id":"T2968","span":{"begin":0,"end":275},"obj":"Sentence"},{"id":"T36","span":{"begin":0,"end":275},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
events-check-again
{"project":"events-check-again","denotations":[{"id":"T4479","span":{"begin":27,"end":31},"obj":"Negative_regulation"},{"id":"T4480","span":{"begin":35,"end":40},"obj":"Protein"},{"id":"T4481","span":{"begin":41,"end":49},"obj":"Gene_expression"},{"id":"T4482","span":{"begin":63,"end":71},"obj":"Positive_regulation"},{"id":"T4483","span":{"begin":77,"end":87},"obj":"Negative_regulation"},{"id":"T4484","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T4485","span":{"begin":97,"end":107},"obj":"Gene_expression"},{"id":"T4486","span":{"begin":163,"end":168},"obj":"Protein"},{"id":"T4487","span":{"begin":188,"end":191},"obj":"Protein"},{"id":"T4488","span":{"begin":269,"end":274},"obj":"Protein"}],"relations":[{"id":"R3459","pred":"themeOf","subj":"T4479","obj":"T4482"},{"id":"R3461","pred":"themeOf","subj":"T4480","obj":"T4479"},{"id":"R3462","pred":"themeOf","subj":"T4480","obj":"T4481"},{"id":"R3463","pred":"causeOf","subj":"T4483","obj":"T4482"},{"id":"R3464","pred":"themeOf","subj":"T4484","obj":"T4485"},{"id":"R3465","pred":"themeOf","subj":"T4485","obj":"T4483"}],"attributes":[{"id":"M54","pred":"Speculation","subj":"T4482","obj":"true"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
bionlp-st-ge-2016-reference-tees
{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T4575","span":{"begin":35,"end":40},"obj":"Protein"},{"id":"T4576","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T4577","span":{"begin":188,"end":192},"obj":"Protein"},{"id":"T4578","span":{"begin":269,"end":274},"obj":"Protein"},{"id":"T4579","span":{"begin":27,"end":31},"obj":"Negative_regulation"},{"id":"T4580","span":{"begin":41,"end":49},"obj":"Gene_expression"},{"id":"T4581","span":{"begin":63,"end":71},"obj":"Positive_regulation"},{"id":"T4582","span":{"begin":97,"end":107},"obj":"Gene_expression"},{"id":"T4583","span":{"begin":27,"end":31},"obj":"Negative_regulation"},{"id":"T4584","span":{"begin":77,"end":87},"obj":"Negative_regulation"}],"relations":[{"id":"R3487","pred":"themeOf","subj":"T4575","obj":"T4579"},{"id":"R3488","pred":"themeOf","subj":"T4575","obj":"T4580"},{"id":"R3489","pred":"themeOf","subj":"T4576","obj":"T4582"},{"id":"R3491","pred":"themeOf","subj":"T4579","obj":"T4581"},{"id":"R3492","pred":"themeOf","subj":"T4580","obj":"T4583"},{"id":"R3494","pred":"themeOf","subj":"T4582","obj":"T4584"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}
test2
{"project":"test2","denotations":[{"id":"T2790","span":{"begin":27,"end":31},"obj":"Negative_regulation"},{"id":"T2791","span":{"begin":35,"end":40},"obj":"Protein"},{"id":"T2792","span":{"begin":41,"end":49},"obj":"Gene_expression"},{"id":"T2793","span":{"begin":63,"end":71},"obj":"Positive_regulation"},{"id":"T2794","span":{"begin":77,"end":87},"obj":"Negative_regulation"},{"id":"T2795","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T2796","span":{"begin":97,"end":107},"obj":"Gene_expression"},{"id":"T2797","span":{"begin":154,"end":162},"obj":"Positive_regulation"},{"id":"T2798","span":{"begin":163,"end":168},"obj":"Protein"},{"id":"T2799","span":{"begin":188,"end":191},"obj":"Protein"},{"id":"T2800","span":{"begin":269,"end":274},"obj":"Protein"}],"relations":[{"id":"R2094","pred":"causeOf","subj":"T2790","obj":"T2793"},{"id":"R2095","pred":"themeOf","subj":"T2791","obj":"T2792"},{"id":"R2096","pred":"themeOf","subj":"T2792","obj":"T2790"},{"id":"R2097","pred":"themeOf","subj":"T2795","obj":"T2796"},{"id":"R2098","pred":"themeOf","subj":"T2796","obj":"T2794"},{"id":"R2099","pred":"themeOf","subj":"T2798","obj":"T2797"}],"text":"To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12."}