PMC:2791889 / 3461-3852
Annnotations
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1153 | 30-78 | P40763 | denotes | signal transducer and activator of transcription |
T1154 | 30-78 | P42226 | denotes | signal transducer and activator of transcription |
T1155 | 30-78 | Q14765 | denotes | signal transducer and activator of transcription |
T1156 | 124-129 | P01579 | denotes | IFN-γ |
T1157 | 166-171 | Q9UL17 | denotes | T-bet |
T1158 | 178-183 | P29460 | denotes | IL-12 |
T1159 | 178-183 | P29459 | denotes | IL-12 |
T1160 | 192-197 | Q14765 | denotes | STAT4 |
T1161 | 311-316 | P01579 | denotes | IFN-γ |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1038 | 30-87 | Protein | denotes | signal transducer and activator of transcription (STAT)1 |
T1039 | 87-97 | Positive_regulation | denotes | activation |
T1040 | 99-106 | Positive_regulation | denotes | induced |
T1041 | 99-106 | Positive_regulation | denotes | induced |
T1042 | 110-120 | Protein | denotes | type I IFN |
T1043 | 124-129 | Protein | denotes | IFN-γ |
T1044 | 156-164 | Protein | denotes | T-box 21 |
T1045 | 166-171 | Protein | denotes | T-bet |
T1046 | 178-183 | Protein | denotes | IL-12 |
T1047 | 192-197 | Protein | denotes | STAT4 |
T1048 | 231-236 | Protein | denotes | IL-18 |
T1049 | 237-244 | Positive_regulation | denotes | induced |
T1050 | 245-249 | Protein | denotes | IRAK |
T1051 | 285-290 | Positive_regulation | denotes | drive |
T1052 | 300-307 | Gene_expression | denotes | amounts |
T1053 | 311-316 | Protein | denotes | IFN-γ |
R758 | T1050 | T1049 | themeOf | IRAK,induced |
R759 | T1052 | T1051 | themeOf | amounts,drive |
R760 | T1053 | T1052 | themeOf | IFN-γ,amounts |
R750 | T1038 | T1039 | themeOf | signal transducer and activator of transcription (STAT)1 ,activation |
R751 | T1039 | T1041 | themeOf | activation,induced |
R752 | T1039 | T1040 | themeOf | activation,induced |
R753 | T1039 | T1051 | causeOf | activation,drive |
R754 | T1042 | T1041 | causeOf | type I IFN,induced |
R755 | T1043 | T1040 | causeOf | IFN-γ,induced |
R756 | T1045 | T1044 | equivalentTo | T-bet,T-box 21 |
R757 | T1048 | T1049 | causeOf | IL-18,induced |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
19646904-10898785-46582679 | 385-389 | 10898785 | denotes | 2000 |
T57018 | 385-389 | 10898785 | denotes | 2000 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1676 | 0-3 | CD | denotes | Th1 |
T1677 | 4-8 | NN | denotes | cell |
T1678 | 9-20 | NN | denotes | development |
T1679 | 21-29 | VBZ | denotes | requires |
T1680 | 30-36 | NN | denotes | signal |
T1681 | 37-47 | NN | denotes | transducer |
T1682 | 48-51 | CC | denotes | and |
T1683 | 52-61 | NN | denotes | activator |
T1684 | 62-64 | IN | denotes | of |
T1685 | 65-78 | NN | denotes | transcription |
T1686 | 79-80 | -LRB- | denotes | ( |
T1687 | 80-84 | NNP | denotes | STAT |
T1688 | 84-85 | -RRB- | denotes | ) |
T1689 | 85-86 | CD | denotes | 1 |
T1690 | 87-97 | NN | denotes | activation |
T1691 | 97-98 | , | denotes | , |
T1692 | 99-106 | VBN | denotes | induced |
T1693 | 107-109 | IN | denotes | by |
T1694 | 110-114 | NN | denotes | type |
T1695 | 115-116 | PRP | denotes | I |
T1696 | 117-120 | VBP | denotes | IFN |
T1697 | 121-123 | CC | denotes | or |
T1698 | 124-129 | VBP | denotes | IFN-γ |
T1699 | 129-130 | , | denotes | , |
T1700 | 131-134 | DT | denotes | the |
T1701 | 135-148 | NN | denotes | transcription |
T1702 | 149-155 | NN | denotes | factor |
T1703 | 156-161 | NN | denotes | T-box |
T1704 | 162-164 | CD | denotes | 21 |
T1705 | 165-166 | -LRB- | denotes | ( |
T1706 | 166-171 | NN | denotes | T-bet |
T1707 | 171-172 | -RRB- | denotes | ) |
T1708 | 172-173 | , | denotes | , |
T1709 | 174-177 | CC | denotes | and |
T1710 | 178-191 | JJ | denotes | IL-12-induced |
T1711 | 192-197 | CD | denotes | STAT4 |
T1712 | 198-207 | VBG | denotes | signaling |
T1713 | 207-208 | , | denotes | , |
T1714 | 209-214 | WDT | denotes | which |
T1715 | 215-218 | MD | denotes | can |
T1716 | 219-225 | NN | denotes | couple |
T1717 | 226-230 | IN | denotes | with |
T1718 | 231-244 | JJ | denotes | IL-18-induced |
T1719 | 245-249 | NNP | denotes | IRAK |
T1720 | 250-253 | CC | denotes | and |
T1721 | 254-259 | NNP | denotes | NF-κB |
T1722 | 260-273 | NN | denotes | transcription |
T1723 | 274-281 | NNS | denotes | factors |
T1724 | 282-284 | TO | denotes | to |
T1725 | 285-290 | VB | denotes | drive |
T1726 | 291-294 | DT | denotes | the |
T1727 | 295-299 | JJ | denotes | high |
T1728 | 300-307 | NNS | denotes | amounts |
T1729 | 308-310 | IN | denotes | of |
T1730 | 311-316 | JJ | denotes | IFN-γ |
T1731 | 317-325 | VBN | denotes | required |
T1732 | 326-328 | TO | denotes | to |
T1733 | 329-338 | VB | denotes | eradicate |
T1734 | 339-352 | JJ | denotes | intracellular |
T1735 | 353-362 | NNS | denotes | pathogens |
T1736 | 363-364 | -LRB- | denotes | ( |
T1737 | 364-372 | NNP | denotes | Glimcher |
T1738 | 373-376 | CC | denotes | and |
T1739 | 377-383 | NNP | denotes | Murphy |
T1740 | 383-384 | , | denotes | , |
T1741 | 385-389 | CD | denotes | 2000 |
T1742 | 389-390 | -RRB- | denotes | ) |
T1743 | 390-391 | . | denotes | . |
R1296 | T1676 | T1678 | nummod | Th1,development |
R1297 | T1677 | T1678 | compound | cell,development |
R1298 | T1678 | T1679 | nsubj | development,requires |
R1299 | T1679 | T1679 | ROOT | requires,requires |
R1300 | T1680 | T1681 | compound | signal,transducer |
R1301 | T1681 | T1679 | dobj | transducer,requires |
R1302 | T1682 | T1681 | cc | and,transducer |
R1303 | T1683 | T1681 | conj | activator,transducer |
R1304 | T1684 | T1683 | prep | of,activator |
R1305 | T1685 | T1684 | pobj | transcription,of |
R1306 | T1686 | T1685 | punct | (,transcription |
R1307 | T1687 | T1685 | appos | STAT,transcription |
R1308 | T1688 | T1685 | punct | ),transcription |
R1309 | T1689 | T1690 | nummod | 1,activation |
R1310 | T1690 | T1683 | conj | activation,activator |
R1311 | T1691 | T1690 | punct | ",",activation |
R1312 | T1692 | T1690 | acl | induced,activation |
R1313 | T1693 | T1692 | agent | by,induced |
R1314 | T1694 | T1693 | pobj | type,by |
R1315 | T1695 | T1696 | nsubj | I,IFN |
R1316 | T1696 | T1694 | relcl | IFN,type |
R1317 | T1697 | T1696 | cc | or,IFN |
R1318 | T1698 | T1696 | conj | IFN-γ,IFN |
R1319 | T1699 | T1712 | punct | ",",signaling |
R1320 | T1700 | T1702 | det | the,factor |
R1321 | T1701 | T1702 | compound | transcription,factor |
R1322 | T1702 | T1712 | nsubj | factor,signaling |
R1323 | T1703 | T1702 | appos | T-box,factor |
R1324 | T1704 | T1703 | nummod | 21,T-box |
R1325 | T1705 | T1706 | punct | (,T-bet |
R1326 | T1706 | T1703 | appos | T-bet,T-box |
R1327 | T1707 | T1706 | punct | ),T-bet |
R1328 | T1708 | T1703 | punct | ",",T-box |
R1329 | T1709 | T1703 | cc | and,T-box |
R1330 | T1710 | T1703 | conj | IL-12-induced,T-box |
R1331 | T1711 | T1712 | nummod | STAT4,signaling |
R1332 | T1712 | T1679 | ccomp | signaling,requires |
R1333 | T1713 | T1712 | punct | ",",signaling |
R1334 | T1714 | T1716 | nsubj | which,couple |
R1335 | T1715 | T1716 | aux | can,couple |
R1336 | T1716 | T1712 | relcl | couple,signaling |
R1337 | T1717 | T1716 | prep | with,couple |
R1338 | T1718 | T1719 | compound | IL-18-induced,IRAK |
R1339 | T1719 | T1717 | pobj | IRAK,with |
R1340 | T1720 | T1719 | cc | and,IRAK |
R1341 | T1721 | T1719 | conj | NF-κB,IRAK |
R1342 | T1722 | T1723 | compound | transcription,factors |
R1343 | T1723 | T1716 | dobj | factors,couple |
R1344 | T1724 | T1725 | aux | to,drive |
R1345 | T1725 | T1723 | relcl | drive,factors |
R1346 | T1726 | T1728 | det | the,amounts |
R1347 | T1727 | T1728 | amod | high,amounts |
R1348 | T1728 | T1725 | dobj | amounts,drive |
R1349 | T1729 | T1728 | prep | of,amounts |
R1350 | T1730 | T1731 | amod | IFN-γ,required |
R1351 | T1731 | T1728 | acl | required,amounts |
R1352 | T1732 | T1733 | aux | to,eradicate |
R1353 | T1733 | T1731 | xcomp | eradicate,required |
R1354 | T1734 | T1735 | amod | intracellular,pathogens |
R1355 | T1735 | T1733 | dobj | pathogens,eradicate |
R1356 | T1736 | T1737 | punct | (,Glimcher |
R1357 | T1737 | T1716 | npadvmod | Glimcher,couple |
R1358 | T1738 | T1737 | cc | and,Glimcher |
R1359 | T1739 | T1737 | conj | Murphy,Glimcher |
R1360 | T1740 | T1739 | punct | ",",Murphy |
R1361 | T1741 | T1737 | appos | 2000,Glimcher |
R1362 | T1742 | T1737 | punct | ),Glimcher |
R1363 | T1743 | T1712 | punct | .,signaling |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2168 | 65-78 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T2169 | 135-148 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T2170 | 260-273 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T2156 | 198-207 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T2162 | 4-20 | http://purl.obolibrary.org/obo/GO_0048468 | denotes | cell development |
T2164 | 9-20 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2205 | 178-183 | http://purl.obolibrary.org/obo/GO_0005143 | denotes | IL-12 |
T2208 | 231-236 | http://purl.obolibrary.org/obo/GO_0045515 | denotes | IL-18 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2231 | 4-8 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2244 | 339-352 | http://purl.obolibrary.org/obo/GO_0005622 | denotes | intracellular |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1124 | 0-391 | Sentence | denotes | Th1 cell development requires signal transducer and activator of transcription (STAT)1 activation, induced by type I IFN or IFN-γ, the transcription factor T-box 21 (T-bet), and IL-12-induced STAT4 signaling, which can couple with IL-18-induced IRAK and NF-κB transcription factors to drive the high amounts of IFN-γ required to eradicate intracellular pathogens (Glimcher and Murphy, 2000). |
T20 | 0-391 | Sentence | denotes | Th1 cell development requires signal transducer and activator of transcription (STAT)1 activation, induced by type I IFN or IFN-γ, the transcription factor T-box 21 (T-bet), and IL-12-induced STAT4 signaling, which can couple with IL-18-induced IRAK and NF-κB transcription factors to drive the high amounts of IFN-γ required to eradicate intracellular pathogens (Glimcher and Murphy, 2000). |
events-check-again
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2475 | 30-87 | Protein | denotes | signal transducer and activator of transcription (STAT)1 |
T2476 | 87-97 | Positive_regulation | denotes | activation |
T2477 | 99-106 | Positive_regulation | denotes | induced |
T2478 | 99-106 | Positive_regulation | denotes | induced |
T2479 | 110-120 | Protein | denotes | type I IFN |
T2480 | 124-129 | Protein | denotes | IFN-γ |
T2481 | 156-164 | Protein | denotes | T-box 21 |
T2482 | 166-171 | Protein | denotes | T-bet |
T2483 | 178-183 | Protein | denotes | IL-12 |
T2484 | 192-197 | Protein | denotes | STAT4 |
T2485 | 231-236 | Protein | denotes | IL-18 |
T2486 | 237-244 | Positive_regulation | denotes | induced |
T2487 | 245-249 | Protein | denotes | IRAK |
T2488 | 285-290 | Positive_regulation | denotes | drive |
T2489 | 300-307 | Gene_expression | denotes | amounts |
T2490 | 311-316 | Protein | denotes | IFN-γ |
R1880 | T2489 | T2488 | themeOf | amounts,drive |
R1881 | T2490 | T2489 | themeOf | IFN-γ,amounts |
R1905 | T2475 | T2476 | themeOf | signal transducer and activator of transcription (STAT)1 ,activation |
R1906 | T2476 | T2478 | themeOf | activation,induced |
R1907 | T2476 | T2477 | themeOf | activation,induced |
R1908 | T2476 | T2488 | causeOf | activation,drive |
R1910 | T2479 | T2478 | causeOf | type I IFN,induced |
R1911 | T2480 | T2477 | causeOf | IFN-γ,induced |
R1914 | T2482 | T2481 | equivalentTo | T-bet,T-box 21 |
R1916 | T2485 | T2486 | causeOf | IL-18,induced |
R1919 | T2487 | T2486 | themeOf | IRAK,induced |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2579 | 110-120 | Protein | denotes | type I IFN |
T2580 | 124-129 | Protein | denotes | IFN-γ |
T2581 | 192-197 | Protein | denotes | STAT4 |
T2582 | 231-236 | Protein | denotes | IL-18 |
T2583 | 245-249 | Protein | denotes | IRAK |
T2584 | 254-281 | Protein | denotes | NF-κB transcription factors |
T2585 | 311-316 | Protein | denotes | IFN-γ |
T2586 | 237-244 | Positive_regulation | denotes | induced |
R1949 | T2582 | T2586 | causeOf | IL-18,induced |
R1950 | T2583 | T2586 | themeOf | IRAK,induced |
test2
Id | Subject | Object | Predicate | Lexical cue | Negation |
---|---|---|---|---|---|
T949 | 30-86 | Protein | denotes | signal transducer and activator of transcription (STAT)1 | |
T950 | 99-106 | Positive_regulation | denotes | induced | |
T951 | 110-120 | Protein | denotes | type I IFN | |
T952 | 124-129 | Protein | denotes | IFN-γ | |
T953 | 156-164 | Protein | denotes | T-box 21 | |
T954 | 166-171 | Protein | denotes | T-bet | |
T955 | 178-183 | Protein | denotes | IL-12 | |
T956 | 184-191 | Positive_regulation | denotes | induced | |
T957 | 192-197 | Protein | denotes | STAT4 | |
T958 | 231-236 | Protein | denotes | IL-18 | true |
T959 | 237-244 | Positive_regulation | denotes | induced | |
T960 | 245-249 | Protein | denotes | IRAK | |
T961 | 311-316 | Protein | denotes | IFN-γ | |
R698 | T952 | T950 | causeOf | IFN-γ,induced | |
R699 | T954 | T953 | equivalentTo | T-bet,T-box 21 | |
R700 | T955 | T956 | causeOf | IL-12,induced | |
R701 | T956 | T950 | themeOf | induced,induced | |
R702 | T958 | T959 | causeOf | IL-18,induced | |
R703 | T960 | T959 | themeOf | IRAK,induced |