PMC:2791889 / 18477-18748 JSONTXT

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    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T11211","span":{"begin":15,"end":19},"obj":"P27361"},{"id":"T11212","span":{"begin":24,"end":28},"obj":"P28482"},{"id":"T11213","span":{"begin":86,"end":91},"obj":"P22301"},{"id":"T11214","span":{"begin":129,"end":134},"obj":"P22301"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    bionlp-st-ge-2016-reference

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    pmc-enju-pas

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showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    bionlp-st-ge-2016-spacy-parsed

    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showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T11413","span":{"begin":129,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0032653"},{"id":"T11417","span":{"begin":129,"end":145},"obj":"http://purl.obolibrary.org/obo/GO_0032613"},{"id":"T11421","span":{"begin":15,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T11424","span":{"begin":24,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T11428","span":{"begin":15,"end":39},"obj":"http://purl.obolibrary.org/obo/GO_0070374"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    GO-MF

    {"project":"GO-MF","denotations":[{"id":"T11437","span":{"begin":86,"end":91},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T11438","span":{"begin":129,"end":134},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T11443","span":{"begin":15,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T11446","span":{"begin":24,"end":28},"obj":"http://purl.obolibrary.org/obo/GO_0004707"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T11452","span":{"begin":167,"end":172},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    sentences

    {"project":"sentences","denotations":[{"id":"T11024","span":{"begin":0,"end":271},"obj":"Sentence"},{"id":"T95","span":{"begin":0,"end":271},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    events-check-again

    {"project":"events-check-again","denotations":[{"id":"T11572","span":{"begin":15,"end":19},"obj":"Protein"},{"id":"T11573","span":{"begin":24,"end":28},"obj":"Protein"},{"id":"T11574","span":{"begin":29,"end":39},"obj":"Positive_regulation"},{"id":"T11575","span":{"begin":29,"end":39},"obj":"Positive_regulation"},{"id":"T11576","span":{"begin":60,"end":68},"obj":"Positive_regulation"},{"id":"T11577","span":{"begin":60,"end":68},"obj":"Positive_regulation"},{"id":"T11578","span":{"begin":73,"end":82},"obj":"Gene_expression"},{"id":"T11579","span":{"begin":86,"end":91},"obj":"Protein"},{"id":"T11580","span":{"begin":129,"end":134},"obj":"Protein"},{"id":"T11581","span":{"begin":135,"end":145},"obj":"Gene_expression"},{"id":"T11582","span":{"begin":186,"end":195},"obj":"Negative_regulation"},{"id":"T11583","span":{"begin":219,"end":222},"obj":"Protein"},{"id":"T11584","span":{"begin":223,"end":232},"obj":"Negative_regulation"}],"relations":[{"id":"R8939","pred":"themeOf","subj":"T11572","obj":"T11575"},{"id":"R8940","pred":"themeOf","subj":"T11573","obj":"T11574"},{"id":"R8941","pred":"causeOf","subj":"T11574","obj":"T11576"},{"id":"R8942","pred":"causeOf","subj":"T11575","obj":"T11577"},{"id":"R8943","pred":"themeOf","subj":"T11578","obj":"T11577"},{"id":"R8944","pred":"themeOf","subj":"T11578","obj":"T11576"},{"id":"R8945","pred":"themeOf","subj":"T11579","obj":"T11578"},{"id":"R8946","pred":"themeOf","subj":"T11580","obj":"T11581"},{"id":"R8947","pred":"themeOf","subj":"T11581","obj":"T11582"},{"id":"R8948","pred":"themeOf","subj":"T11583","obj":"T11584"},{"id":"R8949","pred":"causeOf","subj":"T11584","obj":"T11582"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    bionlp-st-ge-2016-reference-tees

    {"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T11615","span":{"begin":15,"end":19},"obj":"Protein"},{"id":"T11616","span":{"begin":24,"end":28},"obj":"Protein"},{"id":"T11617","span":{"begin":86,"end":91},"obj":"Protein"},{"id":"T11618","span":{"begin":219,"end":222},"obj":"Protein"},{"id":"T11619","span":{"begin":29,"end":39},"obj":"Positive_regulation"},{"id":"T11620","span":{"begin":29,"end":39},"obj":"Positive_regulation"},{"id":"T11621","span":{"begin":73,"end":82},"obj":"Positive_regulation"},{"id":"T11622","span":{"begin":223,"end":232},"obj":"Negative_regulation"},{"id":"T11623","span":{"begin":60,"end":68},"obj":"Positive_regulation"},{"id":"T11624","span":{"begin":60,"end":68},"obj":"Positive_regulation"}],"relations":[{"id":"R8968","pred":"themeOf","subj":"T11615","obj":"T11619"},{"id":"R8969","pred":"themeOf","subj":"T11616","obj":"T11620"},{"id":"R8970","pred":"themeOf","subj":"T11617","obj":"T11621"},{"id":"R8971","pred":"themeOf","subj":"T11618","obj":"T11622"},{"id":"R8972","pred":"causeOf","subj":"T11619","obj":"T11623"},{"id":"R8973","pred":"causeOf","subj":"T11620","obj":"T11624"},{"id":"R8974","pred":"themeOf","subj":"T11621","obj":"T11623"},{"id":"R8975","pred":"themeOf","subj":"T11621","obj":"T11624"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}

    test2

    {"project":"test2","denotations":[{"id":"T10949","span":{"begin":15,"end":19},"obj":"Protein"},{"id":"T10950","span":{"begin":24,"end":28},"obj":"Protein"},{"id":"T10951","span":{"begin":29,"end":39},"obj":"Positive_regulation"},{"id":"T10952","span":{"begin":60,"end":68},"obj":"Positive_regulation"},{"id":"T10953","span":{"begin":73,"end":82},"obj":"Positive_regulation"},{"id":"T10954","span":{"begin":86,"end":91},"obj":"Protein"},{"id":"T10955","span":{"begin":129,"end":134},"obj":"Protein"},{"id":"T10956","span":{"begin":135,"end":145},"obj":"Gene_expression"},{"id":"T10957","span":{"begin":186,"end":195},"obj":"Negative_regulation"},{"id":"T10958","span":{"begin":219,"end":222},"obj":"Protein"},{"id":"T10959","span":{"begin":223,"end":232},"obj":"Negative_regulation"}],"relations":[{"id":"R8431","pred":"themeOf","subj":"T10949","obj":"T10951"},{"id":"R8432","pred":"themeOf","subj":"T10950","obj":"T10951"},{"id":"R8433","pred":"causeOf","subj":"T10951","obj":"T10952"},{"id":"R8434","pred":"themeOf","subj":"T10953","obj":"T10952"},{"id":"R8435","pred":"themeOf","subj":"T10954","obj":"T10953"},{"id":"R8436","pred":"themeOf","subj":"T10955","obj":"T10956"},{"id":"R8437","pred":"themeOf","subj":"T10956","obj":"T10957"},{"id":"R8438","pred":"themeOf","subj":"T10958","obj":"T10959"},{"id":"R8439","pred":"causeOf","subj":"T10959","obj":"T10957"}],"attributes":[{"id":"M206","pred":"Negation","subj":"T10958","obj":"true"},{"id":"M205","pred":"Negation","subj":"T10956","obj":"true"}],"text":"We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B)."}