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PMC:2791889 JSONTXT

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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T340 0-14 P22301 denotes Interleukin-10
T341 71-76 Q14765 denotes STAT4
T342 168-171 P01730 denotes CD4
T343 191-205 P22301 denotes interleukin-10
T344 207-212 P22301 denotes IL-10
T345 218-230 P01579 denotes interferon-γ
T346 232-237 P01579 denotes IFN-γ
T347 327-332 P22301 denotes IL-10
T348 411-416 P22301 denotes IL-10
T349 493-497 P27361 denotes ERK1
T350 502-506 P28482 denotes ERK2
T351 540-545 P29459 denotes IL-12
T352 540-545 P29460 denotes IL-12
T353 554-559 Q14765 denotes STAT4
T354 633-638 P22301 denotes IL-10
T355 678-683 P29459 denotes IL-12
T356 678-683 P29460 denotes IL-12
T357 772-777 P22301 denotes IL-10
T358 915-919 P27361 denotes ERK1
T359 924-928 P28482 denotes ERK2
T360 972-977 P22301 denotes IL-10
T361 1002-1007 P22301 denotes IL-10
T362 1040-1045 O75444 denotes c-maf
T363 1042-1045 O75444 denotes maf
T364 1221-1226 P22301 denotes IL-10
T1134 1253-1267 P22301 denotes Interleukin-10
T1135 1269-1274 P22301 denotes IL-10
T1136 1410-1415 P22301 denotes IL-10
T1137 1687-1692 P22301 denotes IL-10
T1138 2244-2247 P01730 denotes CD4
T1139 2253-2256 P10966 denotes CD8
T1140 2253-2256 P01732 denotes CD8
T1141 2282-2285 P01730 denotes CD4
T1142 2313-2325 P01579 denotes interferon-γ
T1143 2327-2332 P01579 denotes IFN-γ
T1144 2338-2343 P22301 denotes IL-10
T1145 2423-2428 P29460 denotes IL-12
T1146 2423-2428 P29459 denotes IL-12
T1147 2581-2586 P01579 denotes IFN-γ
T1148 2591-2596 P22301 denotes IL-10
T1149 2720-2725 P22301 denotes IL-10
T1150 3038-3046 Q04864 denotes relative
T1151 3058-3063 P22301 denotes IL-10
T1152 3068-3073 P01579 denotes IFN-γ
T1153 3491-3539 P40763 denotes signal transducer and activator of transcription
T1154 3491-3539 P42226 denotes signal transducer and activator of transcription
T1155 3491-3539 Q14765 denotes signal transducer and activator of transcription
T1156 3585-3590 P01579 denotes IFN-γ
T1157 3627-3632 Q9UL17 denotes T-bet
T1158 3639-3644 P29460 denotes IL-12
T1159 3639-3644 P29459 denotes IL-12
T1160 3653-3658 Q14765 denotes STAT4
T1161 3772-3777 P01579 denotes IFN-γ
T1162 3894-3898 P05112 denotes IL-4
T1163 3900-3904 P05113 denotes IL-5
T1164 3910-3915 P35225 denotes IL-13
T1165 3926-3930 P05112 denotes IL-4
T1166 3932-3937 P42226 denotes STAT6
T1167 4066-4070 P05231 denotes IL-6
T1168 4072-4077 P01137 denotes TGF-β
T1169 4087-4092 P40763 denotes STAT3
T1170 4142-4147 P51449 denotes RORγt
T1171 4449-4481 P28482 denotes mitogen-activated protein kinase
T1172 4449-4481 P27361 denotes mitogen-activated protein kinase
T1173 4536-4541 P01579 denotes IFN-γ
T1174 4549-4554 P29459 denotes IL-12
T1175 4549-4554 P29460 denotes IL-12
T1176 4615-4619 P27361 denotes ERK1
T1177 4624-4628 P28482 denotes ERK2
T1178 4665-4669 P05112 denotes IL-4
T1179 5004-5009 P22301 denotes IL-10
T1180 5188-5193 P22301 denotes IL-10
T1181 5352-5357 P22301 denotes IL-10
T1182 5389-5392 P01730 denotes CD4
T1183 5411-5416 P29459 denotes IL-12
T1184 5411-5416 P29460 denotes IL-12
T1185 5425-5430 Q14765 denotes STAT4
T1186 5499-5503 P27361 denotes ERK1
T1187 5508-5512 P28482 denotes ERK2
T1188 5572-5576 P27361 denotes ERK1
T1189 5581-5585 P28482 denotes ERK2
T1190 5621-5626 P22301 denotes IL-10
T1191 5708-5713 P22301 denotes IL-10
T3507 5900-5905 P29459 denotes IL-12
T3508 5900-5905 P29460 denotes IL-12
T3509 5978-5983 P22301 denotes IL-10
T3510 6038-6043 P01579 denotes IFN-γ
T3511 6048-6053 P22301 denotes IL-10
T3512 6105-6108 P01730 denotes CD4
T3513 6168-6177 E2RVI8 denotes ovalbumin
T3514 6195-6198 E2RVI8 denotes OVA
T3515 6281-6286 P01579 denotes IFN-γ
T3516 6360-6365 P22301 denotes IL-10
T3517 6516-6520 P05112 denotes IL-4
T3518 6525-6530 P22301 denotes IL-10
T3519 6581-6584 P01730 denotes CD4
T3520 6641-6644 P04234 denotes CD3
T3521 6641-6644 P07766 denotes CD3
T3522 6641-6644 P20963 denotes CD3
T3523 6641-6644 P09693 denotes CD3
T3524 6654-6658 P10747 denotes CD28
T3525 6689-6694 P29460 denotes IL-12
T3526 6689-6694 P29459 denotes IL-12
T3527 6707-6712 P01579 denotes IFN-γ
T3528 6767-6772 P22301 denotes IL-10
T3529 6817-6821 P05112 denotes IL-4
T3530 6871-6876 P22301 denotes IL-10
T3531 6927-6932 P22301 denotes IL-10
T3532 6999-7004 P29459 denotes IL-12
T3533 6999-7004 P29460 denotes IL-12
T3534 7024-7027 P01730 denotes CD4
T3535 7105-7110 P29460 denotes IL-12
T3536 7105-7110 P29459 denotes IL-12
T3537 7137-7142 P29460 denotes IL-12
T3538 7137-7142 P29459 denotes IL-12
T3539 7194-7199 P01579 denotes IFN-γ
T3540 7234-7239 P22301 denotes IL-10
T3541 7268-7273 P29459 denotes IL-12
T3542 7268-7273 P29460 denotes IL-12
T3543 7322-7327 P22301 denotes IL-10
T3544 7440-7445 P29459 denotes IL-12
T3545 7440-7445 P29460 denotes IL-12
T3546 7478-7483 P22301 denotes IL-10
T3547 7530-7535 P22301 denotes IL-10
T3548 7629-7634 P22301 denotes IL-10
T3549 7649-7654 P29459 denotes IL-12
T3550 7649-7654 P29460 denotes IL-12
T3551 7735-7740 P22301 denotes IL-10
T3552 7745-7750 P01579 denotes IFN-γ
T3553 7786-7790 P60568 denotes IL-2
T3554 7828-7833 P29460 denotes IL-12
T3555 7828-7833 P29459 denotes IL-12
T3556 7863-7866 P01730 denotes CD4
T3557 7950-7955 P22301 denotes IL-10
T3558 7992-7997 P22301 denotes IL-10
T3559 8052-8056 P60568 denotes IL-2
T3560 8064-8067 P01730 denotes CD4
T3561 8203-8208 P29460 denotes IL-12
T3562 8203-8208 P29459 denotes IL-12
T3563 8227-8232 P22301 denotes IL-10
T3564 8414-8419 P01137 denotes TGF-β
T3565 8431-8436 P22301 denotes IL-10
T3566 8440-8443 P01730 denotes CD4
T3567 8611-8616 P01137 denotes TGF-β
T3568 8634-8639 P22301 denotes IL-10
T3569 8712-8717 P22301 denotes IL-10
T3570 8771-8776 P29459 denotes IL-12
T3571 8771-8776 P29460 denotes IL-12
T3572 8850-8854 P60568 denotes IL-2
T3573 8858-8863 P01137 denotes TGF-β
T5603 8907-8912 P22301 denotes IL-10
T5604 8953-8958 Q14765 denotes STAT4
T5605 8970-8975 P42226 denotes STAT6
T5606 8977-8982 P01579 denotes IFN-γ
T5607 8987-8991 P05112 denotes IL-4
T5608 9090-9095 P22301 denotes IL-10
T5609 9125-9130 Q14765 denotes STAT4
T5610 9175-9180 P29459 denotes IL-12
T5611 9175-9180 P29460 denotes IL-12
T5612 9210-9213 P01730 denotes CD4
T5613 9244-9249 Q14765 denotes STAT4
T5614 9305-9310 P29459 denotes IL-12
T5615 9305-9310 P29460 denotes IL-12
T5616 9315-9318 E2RVI8 denotes OVA
T5617 9327-9332 P22301 denotes IL-10
T5618 9417-9422 P29460 denotes IL-12
T5619 9417-9422 P29459 denotes IL-12
T5620 9486-9491 Q14765 denotes STAT4
T5621 9528-9533 P01579 denotes IFN-γ
T5622 9640-9644 P05112 denotes IL-4
T5623 9654-9659 P22301 denotes IL-10
T5624 9689-9694 Q14765 denotes STAT4
T5625 9710-9715 P22301 denotes IL-10
T5626 9749-9754 P22301 denotes IL-10
T5627 9788-9792 P05112 denotes IL-4
T5628 9872-9877 P22301 denotes IL-10
T5629 9932-9936 P05112 denotes IL-4
T5630 9950-9955 P42226 denotes STAT6
T5631 10032-10037 P42226 denotes STAT6
T5632 10076-10081 P22301 denotes IL-10
T5633 10121-10126 P29459 denotes IL-12
T5634 10121-10126 P29460 denotes IL-12
T5635 10131-10134 E2RVI8 denotes OVA
T5636 10180-10185 P42226 denotes STAT6
T5637 10239-10244 P22301 denotes IL-10
T5638 10249-10254 P01579 denotes IFN-γ
T5639 10371-10376 P42226 denotes STAT6
T5640 10392-10396 P05112 denotes IL-4
T5641 10401-10406 P22301 denotes IL-10
T5642 10444-10448 P05112 denotes IL-4
T5643 10522-10527 Q14765 denotes STAT4
T5644 10539-10544 P22301 denotes IL-10
T5645 10549-10553 P05112 denotes IL-4
T5646 10686-10691 P22301 denotes IL-10
T5647 10728-10733 P42226 denotes STAT6
T5648 10746-10751 Q14765 denotes STAT4
T5649 10824-10829 Q14765 denotes STAT4
T5650 10859-10864 P22301 denotes IL-10
T5651 10896-10901 P01579 denotes IFN-γ
T5652 10981-10986 P01579 denotes IFN-γ
T5653 11003-11006 P01730 denotes CD4
T5654 11035-11040 P29459 denotes IL-12
T5655 11035-11040 P29460 denotes IL-12
T5656 11065-11068 E2RVI8 denotes OVA
T5657 11087-11092 P22301 denotes IL-10
T5658 11130-11135 P29459 denotes IL-12
T5659 11130-11135 P29460 denotes IL-12
T5660 11170-11175 P01579 denotes IFN-γ
T5661 11220-11225 P22301 denotes IL-10
T5662 11257-11262 P01579 denotes IFN-γ
T5663 11282-11287 P01579 denotes IFN-γ
T5664 11329-11333 P05112 denotes IL-4
T5665 11405-11409 P05112 denotes IL-4
T5666 11452-11457 P22301 denotes IL-10
T5667 11490-11494 P05112 denotes IL-4
T5668 11511-11514 P01730 denotes CD4
T5669 11529-11534 P29459 denotes IL-12
T5670 11529-11534 P29460 denotes IL-12
T5671 11598-11603 P42226 denotes STAT6
T5672 11617-11621 P05112 denotes IL-4
T5673 11689-11694 P22301 denotes IL-10
T5674 11763-11768 P22301 denotes IL-10
T5675 11812-11817 P22301 denotes IL-10
T5676 11945-11950 Q14765 denotes STAT4
T5677 11984-11989 P22301 denotes IL-10
T5678 12018-12023 P42226 denotes STAT6
T7274 12063-12068 Q14765 denotes STAT4
T7275 12112-12117 P22301 denotes IL-10
T7276 12175-12180 P22301 denotes IL-10
T7277 12323-12326 E2RVI8 denotes OVA
T7278 12487-12490 E2RVI8 denotes OVA
T7279 12544-12549 P22301 denotes IL-10
T7280 12554-12559 P01579 denotes IFN-γ
T7281 12590-12595 P22301 denotes IL-10
T7282 12696-12699 E2RVI8 denotes OVA
T7283 12756-12761 Q14765 denotes STAT4
T7284 12766-12771 P42226 denotes STAT6
T7285 12812-12817 P22301 denotes IL-10
T7286 12854-12859 Q14765 denotes STAT4
T7287 12864-12869 P42226 denotes STAT6
T7288 12946-12949 E2RVI8 denotes OVA
T7289 13005-13010 P22301 denotes IL-10
T7290 13015-13020 P01579 denotes IFN-γ
T7291 13089-13094 Q14765 denotes STAT4
T7292 13237-13242 P42226 denotes STAT6
T7293 13260-13265 P22301 denotes IL-10
T7294 13362-13367 P42226 denotes STAT6
T8313 13408-13413 P22301 denotes IL-10
T8314 13471-13476 P29460 denotes IL-12
T8315 13471-13476 P29459 denotes IL-12
T8316 13566-13571 P29459 denotes IL-12
T8317 13566-13571 P29460 denotes IL-12
T8318 13580-13585 Q14765 denotes STAT4
T8319 13616-13621 P22301 denotes IL-10
T8320 13646-13649 P01730 denotes CD4
T8321 13757-13762 P29460 denotes IL-12
T8322 13757-13762 P29459 denotes IL-12
T8323 13813-13818 P29459 denotes IL-12
T8324 13813-13818 P29460 denotes IL-12
T8325 13848-13853 P22301 denotes IL-10
T8326 13949-13954 P22301 denotes IL-10
T8327 14051-14056 P29459 denotes IL-12
T8328 14051-14056 P29460 denotes IL-12
T8329 14087-14092 P22301 denotes IL-10
T8330 14180-14185 P29460 denotes IL-12
T8331 14180-14185 P29459 denotes IL-12
T8332 14190-14195 P22301 denotes IL-10
T8333 14236-14241 P22301 denotes IL-10
T8334 14354-14359 P29459 denotes IL-12
T8335 14354-14359 P29460 denotes IL-12
T8336 14447-14452 P22301 denotes IL-10
T8337 14518-14523 P22301 denotes IL-10
T8338 14563-14566 P01730 denotes CD4
T8339 14627-14632 P29459 denotes IL-12
T8340 14627-14632 P29460 denotes IL-12
T8341 14772-14777 P29460 denotes IL-12
T8342 14772-14777 P29459 denotes IL-12
T8343 14838-14843 P22301 denotes IL-10
T8344 14883-14888 P29459 denotes IL-12
T8345 14883-14888 P29460 denotes IL-12
T8346 14919-14924 P22301 denotes IL-10
T8347 14959-14962 E2RVI8 denotes OVA
T8348 15027-15032 P29460 denotes IL-12
T8349 15027-15032 P29459 denotes IL-12
T8350 15111-15116 P29460 denotes IL-12
T8351 15111-15116 P29459 denotes IL-12
T8352 15156-15161 P22301 denotes IL-10
T8353 15180-15183 P01730 denotes CD4
T8354 15237-15242 P29460 denotes IL-12
T8355 15237-15242 P29459 denotes IL-12
T8356 15309-15314 P01579 denotes IFN-γ
T8357 15326-15331 P22301 denotes IL-10
T8358 15370-15375 P22301 denotes IL-10
T8359 15408-15413 P29459 denotes IL-12
T8360 15408-15413 P29460 denotes IL-12
T8361 15492-15497 P29460 denotes IL-12
T8362 15492-15497 P29459 denotes IL-12
T8363 15543-15548 P22301 denotes IL-10
T9834 15575-15580 P22301 denotes IL-10
T9835 15614-15618 P27361 denotes ERK1
T9836 15623-15627 P28482 denotes ERK2
T9837 15679-15684 P22301 denotes IL-10
T9838 15818-15823 P29459 denotes IL-12
T9839 15818-15823 P29460 denotes IL-12
T9840 15895-15899 P27361 denotes ERK1
T9841 15904-15908 P28482 denotes ERK2
T9842 15977-15980 P01730 denotes CD4
T9843 16071-16074 P01730 denotes CD4
T9844 16192-16196 P27361 denotes ERK1
T9845 16201-16205 P28482 denotes ERK2
T9846 16364-16368 P27361 denotes ERK1
T9847 16373-16377 P28482 denotes ERK2
T9848 16408-16413 P29459 denotes IL-12
T9849 16408-16413 P29460 denotes IL-12
T9850 16532-16536 P27361 denotes ERK1
T9851 16541-16545 P28482 denotes ERK2
T9852 16591-16596 P22301 denotes IL-10
T9853 16866-16869 P20963 denotes CD3
T9854 16866-16869 P09693 denotes CD3
T9855 16866-16869 P04234 denotes CD3
T9856 16866-16869 P07766 denotes CD3
T9857 16895-16900 P29460 denotes IL-12
T9858 16895-16900 P29459 denotes IL-12
T9859 16972-16977 P29460 denotes IL-12
T9860 16972-16977 P29459 denotes IL-12
T9861 17028-17033 P22301 denotes IL-10
T9862 17038-17043 P01579 denotes IFN-γ
T9863 17143-17148 P22301 denotes IL-10
T9864 17170-17173 P09693 denotes CD3
T9865 17170-17173 P07766 denotes CD3
T9866 17170-17173 P04234 denotes CD3
T9867 17170-17173 P20963 denotes CD3
T9868 17264-17268 Q02750 denotes MEK1
T9869 17274-17278 P36507 denotes MEK2
T9870 17303-17307 P27361 denotes ERK1
T9871 17312-17316 P28482 denotes ERK2
T9872 17412-17416 Q02750 denotes MEK1
T9873 17421-17425 P36507 denotes MEK2
T9874 17484-17488 Q02750 denotes MEK1
T9875 17493-17497 P36507 denotes MEK2
T9876 17591-17596 P22301 denotes IL-10
T9877 17746-17749 Q16539 denotes p38
T9878 17746-17749 O15264 denotes p38
T9879 17746-17749 Q15759 denotes p38
T9880 17746-17749 P53778 denotes p38
T9881 17783-17788 P49841 denotes GSK3β
T9882 17842-17847 P22301 denotes IL-10
T9883 17915-17920 P22301 denotes IL-10
T9884 17982-17987 P29459 denotes IL-12
T9885 17982-17987 P29460 denotes IL-12
T9886 17997-18001 P27361 denotes ERK1
T9887 18006-18010 P28482 denotes ERK2
T9888 18052-18055 O15264 denotes p38
T9889 18052-18055 Q16539 denotes p38
T9890 18052-18055 P53778 denotes p38
T9891 18052-18055 Q15759 denotes p38
T9892 18063-18068 P49841 denotes GSK3β
T11200 18080-18085 P22301 denotes IL-10
T11201 18133-18137 P27361 denotes ERK1
T11202 18142-18146 P28482 denotes ERK2
T11203 18177-18182 P22301 denotes IL-10
T11204 18238-18242 P27361 denotes ERK1
T11205 18247-18251 P28482 denotes ERK2
T11206 18304-18307 P04234 denotes CD3
T11207 18304-18307 P07766 denotes CD3
T11208 18304-18307 P09693 denotes CD3
T11209 18304-18307 P20963 denotes CD3
T11210 18317-18321 P10747 denotes CD28
T11211 18492-18496 P27361 denotes ERK1
T11212 18501-18505 P28482 denotes ERK2
T11213 18563-18568 P22301 denotes IL-10
T11214 18606-18611 P22301 denotes IL-10
T11215 18776-18779 O15264 denotes p38
T11216 18776-18779 Q15759 denotes p38
T11217 18776-18779 P53778 denotes p38
T11218 18776-18779 Q16539 denotes p38
T11219 18842-18847 P22301 denotes IL-10
T11220 18897-18901 P27361 denotes ERK1
T11221 18906-18910 P28482 denotes ERK2
T11222 18984-18989 P22301 denotes IL-10
T12464 19031-19036 O75444 denotes c-maf
T12465 19033-19036 O75444 denotes maf
T12466 19064-19069 P22301 denotes IL-10
T12467 19178-19183 P22301 denotes IL-10
T12468 19222-19225 P01730 denotes CD4
T12469 19260-19263 E2RVI8 denotes OVA
T12470 19295-19300 P29460 denotes IL-12
T12471 19295-19300 P29459 denotes IL-12
T12472 19438-19441 P05112 denotes Il4
T12473 19496-19501 P29460 denotes IL-12
T12474 19496-19501 P29459 denotes IL-12
T12475 19568-19573 P29459 denotes IL-12
T12476 19568-19573 P29460 denotes IL-12
T12477 19647-19652 P29460 denotes IL-12
T12478 19647-19652 P29459 denotes IL-12
T12479 19740-19744 P22301 denotes Il10
T12480 19809-19812 P05112 denotes Il4
T12481 19905-19908 P05112 denotes Il4
T12482 19958-19963 P29459 denotes IL-12
T12483 19958-19963 P29460 denotes IL-12
T12484 19994-19999 P22301 denotes IL-10
T12485 20083-20088 P29460 denotes IL-12
T12486 20083-20088 P29459 denotes IL-12
T12487 20114-20118 P22301 denotes Il10
T12488 20254-20257 P01730 denotes CD4
T12489 20355-20360 Q9UL17 denotes T-bet
T12490 20401-20406 P29459 denotes IL-12
T12491 20401-20406 P29460 denotes IL-12
T12492 20449-20455 P23771 denotes GATA-3
T12493 20661-20666 P29460 denotes IL-12
T12494 20661-20666 P29459 denotes IL-12
T12495 20751-20756 O75444 denotes c-maf
T12496 20753-20756 O75444 denotes maf
T12497 20911-20916 P29460 denotes IL-12
T12498 20911-20916 P29459 denotes IL-12
T12499 20950-20955 O75444 denotes c-Maf
T12500 20952-20955 O75444 denotes Maf
T12501 21017-21022 P29459 denotes IL-12
T12502 21017-21022 P29460 denotes IL-12
T12503 21038-21043 O75444 denotes c-maf
T12504 21040-21043 O75444 denotes maf
T12505 21064-21069 Q14765 denotes STAT4
T12506 21128-21134 Q16552 denotes IL-17a
T12507 21146-21151 P22301 denotes IL-10
T12508 21170-21175 Q9UL17 denotes T-bet
T12509 21180-21186 P23771 denotes GATA-3
T12510 21337-21342 O75444 denotes c-maf
T12511 21339-21342 O75444 denotes maf
T12512 21407-21412 O75444 denotes c-Maf
T12513 21409-21412 O75444 denotes Maf
T12514 21443-21448 P22301 denotes IL-10
T12515 21532-21566 Q02548 denotes cell-specific transcription factor
T12516 21633-21637 P22301 denotes Il10
T12517 21650-21655 O75444 denotes c-maf
T12518 21652-21655 O75444 denotes maf
T12519 21726-21730 Q02750 denotes MEK1
T12520 21735-21739 P36507 denotes MEK2
T12521 21770-21775 Q9UL17 denotes T-bet
T12522 21780-21785 P51449 denotes RORγt
T15746 21842-21847 P22301 denotes IL-10
T15747 22039-22044 P22301 denotes IL-10
T15748 22184-22189 P22301 denotes IL-10
T15749 22355-22360 P22301 denotes IL-10
T15750 22447-22451 P27361 denotes ERK1
T15751 22456-22460 P28482 denotes ERK2
T15752 22481-22486 P29459 denotes IL-12
T15753 22481-22486 P29460 denotes IL-12
T15754 22524-22529 P22301 denotes IL-10
T15755 22549-22553 P27361 denotes ERK1
T15756 22558-22562 P28482 denotes ERK2
T15757 22626-22631 P22301 denotes IL-10
T15758 22723-22728 P22301 denotes IL-10
T15759 23107-23112 P22301 denotes IL-10
T15760 23397-23402 P22301 denotes IL-10
T15761 23433-23438 P22301 denotes IL-10
T15762 23473-23476 P01730 denotes CD4
T15763 23702-23707 P22301 denotes IL-10
T15764 23721-23726 Q9BZS1 denotes Foxp3
T15765 23753-23758 P22301 denotes IL-10
T15766 23763-23768 P01579 denotes IFN-γ
T15767 23879-23884 Q9BZS1 denotes Foxp3
T15768 23939-23944 P22301 denotes IL-10
T15769 24063-24066 P01730 denotes CD4
T15770 24086-24091 P22301 denotes IL-10
T15771 24325-24328 P01730 denotes CD4
T15772 24374-24379 P29460 denotes IL-12
T15773 24374-24379 P29459 denotes IL-12
T15774 24479-24484 P01579 denotes IFN-γ
T15775 24489-24494 P22301 denotes IL-10
T15776 24507-24511 P60568 denotes IL-2
T15777 24635-24639 P60568 denotes IL-2
T15778 24672-24677 P22301 denotes IL-10
T15779 24893-24898 P22301 denotes IL-10
T15780 24972-24975 E2RVI8 denotes OVA
T15781 25031-25036 P22301 denotes IL-10
T15782 25100-25105 Q14765 denotes STAT4
T15783 25369-25374 P29460 denotes IL-12
T15784 25369-25374 P29459 denotes IL-12
T15785 25395-25400 P22301 denotes IL-10
T15786 25544-25549 P22301 denotes IL-10
T15787 25556-25561 P29460 denotes IL-12
T15788 25556-25561 P29459 denotes IL-12
T15789 25580-25585 P22301 denotes IL-10
T15790 25643-25648 P29460 denotes IL-12
T15791 25643-25648 P29459 denotes IL-12
T15792 25668-25673 P01579 denotes IFN-γ
T15793 25754-25759 P01579 denotes IFN-γ
T15794 25773-25778 P22301 denotes IL-10
T15795 25906-25909 P01730 denotes CD4
T15796 25968-25973 P22301 denotes IL-10
T15797 26024-26029 P22301 denotes IL-10
T15798 26117-26122 P29460 denotes IL-12
T15799 26117-26122 P29459 denotes IL-12
T15800 26171-26176 P29459 denotes IL-12
T15801 26171-26176 P29460 denotes IL-12
T15802 26250-26255 P29460 denotes IL-12
T15803 26250-26255 P29459 denotes IL-12
T15804 26290-26295 P22301 denotes IL-10
T15805 26346-26350 P27361 denotes ERK1
T15806 26355-26359 P28482 denotes ERK2
T15807 26400-26405 P01579 denotes IFN-γ
T15808 26464-26469 P29459 denotes IL-12
T15809 26464-26469 P29460 denotes IL-12
T15810 26566-26571 P29460 denotes IL-12
T15811 26566-26571 P29459 denotes IL-12
T15812 26685-26690 P01579 denotes IFN-γ
T15813 26701-26706 P22301 denotes IL-10
T15814 26741-26746 P29459 denotes IL-12
T15815 26741-26746 P29460 denotes IL-12
T15816 26777-26782 P22301 denotes IL-10
T15817 26810-26815 P22301 denotes IL-10
T15818 27106-27111 P22301 denotes IL-10
T15819 27221-27226 P22301 denotes IL-10
T15820 27348-27352 P05112 denotes IL-4
T15821 27445-27449 P27361 denotes ERK1
T15822 27454-27458 P28482 denotes ERK2
T15823 27492-27497 P22301 denotes IL-10
T15824 27666-27671 P22301 denotes IL-10
T15825 27827-27831 P27361 denotes ERK1
T15826 27836-27840 P28482 denotes ERK2
T15827 27872-27877 P22301 denotes IL-10
T15828 28027-28032 P22301 denotes IL-10
T15829 28155-28160 P22301 denotes IL-10
T15830 28275-28280 P22301 denotes IL-10
T15831 28374-28379 Q9UL17 denotes T-bet
T15832 28396-28401 P01579 denotes IFN-γ
T15833 28486-28491 P29459 denotes IL-12
T15834 28486-28491 P29460 denotes IL-12
T15835 28519-28524 P22301 denotes IL-10
T15836 28529-28534 P01579 denotes IFN-γ
T15837 28590-28595 P22301 denotes IL-10
T15838 28625-28630 P29459 denotes IL-12
T15839 28625-28630 P29460 denotes IL-12
T15840 28634-28638 P05112 denotes IL-4
T15841 28650-28655 P22301 denotes IL-10
T15842 28677-28683 P23771 denotes GATA-3
T15843 28728-28733 P22301 denotes IL-10
T15844 28780-28785 P22301 denotes IL-10
T15845 28894-28899 P29460 denotes IL-12
T15846 28894-28899 P29459 denotes IL-12
T15847 28925-28931 P23771 denotes Gata-3
T15848 29002-29007 P22301 denotes IL-10
T15849 29067-29072 O75444 denotes c-maf
T15850 29069-29072 O75444 denotes maf
T15851 29168-29173 P29459 denotes IL-12
T15852 29168-29173 P29460 denotes IL-12
T15853 29206-29211 O75444 denotes c-maf
T15854 29208-29211 O75444 denotes maf
T15855 29236-29241 P22301 denotes IL-10
T15856 29287-29292 P22301 denotes IL-10
T15857 29389-29394 O75444 denotes c-Maf
T15858 29391-29394 O75444 denotes Maf
T15859 29454-29459 P22301 denotes IL-10
T15860 29559-29562 P01730 denotes CD4
T15861 29680-29685 P22301 denotes IL-10
T15862 29687-29691 P27361 denotes ERK1
T15863 29696-29700 P28482 denotes ERK2
T15864 29728-29733 P22301 denotes IL-10
T15865 29808-29813 P22301 denotes IL-10
T15866 29865-29870 P22301 denotes IL-10
T15867 29955-29960 P29460 denotes IL-12
T15868 29955-29960 P29459 denotes IL-12
T15869 30156-30161 P22301 denotes IL-10
T15870 30364-30369 P22301 denotes IL-10
T18696 30650-30653 E2RVI8 denotes OVA
T18697 30698-30702 P05112 denotes IL-4
T18698 30705-30710 P01579 denotes IFN-γ
T18699 30713-30718 Q14765 denotes STAT4
T18700 30725-30730 P42226 denotes STAT6
T18701 31477-31486 E2RVI8 denotes ovalbumin
T18702 31496-31499 E2RVI8 denotes OVA
T18703 31542-31551 E2RVI8 denotes ovalbumin
T18704 31568-31571 E2RVI8 denotes OVA
T18705 31687-31690 P53778 denotes p38
T18706 31687-31690 Q15759 denotes p38
T18707 31687-31690 Q16539 denotes p38
T18708 31687-31690 O15264 denotes p38
T18709 31716-31721 P49841 denotes GSK3β
T19439 31818-31821 P01730 denotes CD4
T19440 31927-31930 P01730 denotes CD4
T19441 31940-31943 P01730 denotes CD4
T19442 31961-31964 P01730 denotes CD4
T19443 32148-32151 P01730 denotes CD4
T19444 32282-32287 P20702 denotes CD11c
T19445 32346-32349 P01730 denotes CD4
T19446 32544-32547 E2RVI8 denotes OVA
T19447 32555-32560 P29460 denotes IL-12
T19448 32555-32560 P29459 denotes IL-12
T19449 32603-32606 P01730 denotes CD4
T19450 32666-32669 P07766 denotes CD3
T19451 32666-32669 P04234 denotes CD3
T19452 32666-32669 P09693 denotes CD3
T19453 32666-32669 P20963 denotes CD3
T19454 32679-32683 P10747 denotes CD28
T19455 33203-33206 Q16539 denotes p38
T19456 33203-33206 P53778 denotes p38
T19457 33203-33206 Q15759 denotes p38
T19458 33203-33206 O15264 denotes p38
T19459 33228-33233 P49841 denotes GSK3β
T20055 33480-33483 P04234 denotes CD3
T20056 33480-33483 P20963 denotes CD3
T20057 33480-33483 P09693 denotes CD3
T20058 33480-33483 P07766 denotes CD3
T20059 33503-33507 P10747 denotes CD28
T20060 33842-33846 P05112 denotes IL-4
T20061 33848-33853 P22301 denotes IL-10
T20062 33859-33864 P01579 denotes IFN-γ
T20402 34180-34183 E2RVI8 denotes OVA
T20403 34362-34365 E2RVI8 denotes OVA
T20404 34584-34587 P01730 denotes CD4
T20405 34610-34615 P01579 denotes IFN-γ
T20406 34620-34625 P22301 denotes IL-10
T20725 34797-34800 P04234 denotes CD3
T20726 34797-34800 P09693 denotes CD3
T20727 34797-34800 P07766 denotes CD3
T20728 34797-34800 P20963 denotes CD3
T20729 34821-34825 P10747 denotes CD28
T20924 35269-35272 P01730 denotes CD4

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T96 0-14 Protein denotes Interleukin-10
T97 15-25 Gene_expression denotes Production
T98 39-47 Positive_regulation denotes Requires
T99 39-47 Positive_regulation denotes Requires
T100 48-62 Protein denotes Interleukin-12
T1029 2569-2580 Gene_expression denotes coproducing
T1030 2581-2586 Protein denotes IFN-γ
T1031 2591-2596 Protein denotes IL-10
T1032 2720-2725 Protein denotes IL-10
T1033 2726-2736 Gene_expression denotes production
T1034 3058-3063 Protein denotes IL-10
T1035 3068-3073 Protein denotes IFN-γ
T1036 3074-3082 Gene_expression denotes produced
T1037 3074-3082 Gene_expression denotes produced
T1038 3491-3548 Protein denotes signal transducer and activator of transcription (STAT)1
T1039 3548-3558 Positive_regulation denotes activation
T1040 3560-3567 Positive_regulation denotes induced
T1041 3560-3567 Positive_regulation denotes induced
T1042 3571-3581 Protein denotes type I IFN
T1043 3585-3590 Protein denotes IFN-γ
T1044 3617-3625 Protein denotes T-box 21
T1045 3627-3632 Protein denotes T-bet
T1046 3639-3644 Protein denotes IL-12
T1047 3653-3658 Protein denotes STAT4
T1048 3692-3697 Protein denotes IL-18
T1049 3698-3705 Positive_regulation denotes induced
T1050 3706-3710 Protein denotes IRAK
T1051 3746-3751 Positive_regulation denotes drive
T1052 3761-3768 Gene_expression denotes amounts
T1053 3772-3777 Protein denotes IFN-γ
T1054 3880-3890 Gene_expression denotes expression
T1055 3880-3890 Gene_expression denotes expression
T1056 3880-3890 Gene_expression denotes expression
T1057 3894-3898 Protein denotes IL-4
T1058 3900-3904 Protein denotes IL-5
T1059 3910-3915 Protein denotes IL-13
T1060 3917-3925 Positive_regulation denotes requires
T1061 3917-3925 Positive_regulation denotes requires
T1062 3917-3925 Positive_regulation denotes requires
T1063 3917-3925 Positive_regulation denotes requires
T1064 3917-3925 Positive_regulation denotes requires
T1065 3917-3925 Positive_regulation denotes requires
T1066 3917-3925 Positive_regulation denotes requires
T1067 3917-3925 Positive_regulation denotes requires
T1068 3917-3925 Positive_regulation denotes requires
T1069 3926-3930 Protein denotes IL-4
T1070 3932-3937 Protein denotes STAT6
T1071 3968-3997 Protein denotes GATA binding protein (GATA)-3
T1072 4066-4070 Protein denotes IL-6
T1073 4072-4077 Protein denotes TGF-β
T1074 4087-4092 Protein denotes STAT3
T1075 4093-4102 Positive_regulation denotes dependent
T1076 4103-4113 Gene_expression denotes expression
T1077 4142-4147 Protein denotes RORγt
T1078 4506-4512 Positive_regulation denotes result
T1079 4526-4535 Gene_expression denotes producing
T1080 4536-4541 Protein denotes IFN-γ
T1081 4549-4554 Protein denotes IL-12
T1082 4555-4566 Regulation denotes independent true
T1083 4615-4619 Protein denotes ERK1
T1084 4624-4628 Protein denotes ERK2
T1085 4629-4639 Positive_regulation denotes activation
T1086 4629-4639 Positive_regulation denotes activation
T1087 4641-4646 Positive_regulation denotes favor
T1088 4641-4646 Positive_regulation denotes favor
T1089 4665-4669 Protein denotes IL-4
T1090 4670-4679 Localization denotes secretion
T1091 5004-5009 Protein denotes IL-10
T1092 5010-5018 Gene_expression denotes produced
T1093 5050-5077 Regulation denotes act as a feedback regulator true
T1094 5188-5193 Protein denotes IL-10
T1095 5194-5204 Gene_expression denotes production
T1096 5243-5250 Positive_regulation denotes induced
T1097 5352-5357 Protein denotes IL-10
T1098 5358-5367 Gene_expression denotes producing
T1099 5389-5392 Protein denotes CD4
T1100 5411-5416 Protein denotes IL-12
T1101 5425-5430 Protein denotes STAT4
T1102 5499-5503 Protein denotes ERK1
T1103 5508-5512 Protein denotes ERK2
T1104 5513-5528 Phosphorylation denotes phosphorylation
T1105 5513-5528 Phosphorylation denotes phosphorylation
T1106 5558-5568 Positive_regulation denotes activation
T1107 5558-5568 Positive_regulation denotes activation
T1108 5572-5576 Protein denotes ERK1
T1109 5581-5585 Protein denotes ERK2
T1110 5591-5602 Positive_regulation denotes requirement
T1111 5591-5602 Positive_regulation denotes requirement
T1112 5607-5617 Gene_expression denotes production
T1113 5621-5626 Protein denotes IL-10
T1114 5708-5713 Protein denotes IL-10
T1115 5714-5723 Positive_regulation denotes induction
T2869 6195-6198 Protein denotes OVA
T2870 6252-6256 Positive_regulation denotes rise
T2871 6252-6256 Positive_regulation denotes rise
T2872 6270-6280 Gene_expression denotes expressing true
T2873 6270-6280 Gene_expression denotes expressing
T2874 6281-6286 Protein denotes IFN-γ
T2875 6360-6365 Protein denotes IL-10
T2876 6501-6510 Gene_expression denotes expressed
T2877 6501-6510 Gene_expression denotes expressed
T2878 6516-6520 Protein denotes IL-4
T2879 6525-6530 Protein denotes IL-10
T2880 6581-6584 Protein denotes CD4
T2881 6641-6644 Protein denotes CD3
T2882 6654-6658 Protein denotes CD28
T2883 6689-6694 Protein denotes IL-12
T2884 6695-6703 Positive_regulation denotes resulted
T2885 6695-6703 Positive_regulation denotes resulted
T2886 6707-6712 Protein denotes IFN-γ
T2887 6713-6722 Gene_expression denotes producing
T2888 6756-6766 Gene_expression denotes coproduced
T2889 6767-6772 Protein denotes IL-10
T2890 6817-6821 Protein denotes IL-4
T2891 6863-6867 Negative_regulation denotes lack
T2892 6871-6876 Protein denotes IL-10
T2893 6877-6885 Gene_expression denotes produced
T2894 6899-6907 Positive_regulation denotes resulted true
T2895 6913-6923 Negative_regulation denotes inhibition
T2896 6927-6932 Protein denotes IL-10
T2897 6933-6943 Gene_expression denotes production
T2898 6999-7004 Protein denotes IL-12
T2899 7024-7027 Protein denotes CD4
T2900 7105-7110 Protein denotes IL-12
T2901 7137-7142 Protein denotes IL-12
T2902 7186-7193 Positive_regulation denotes induced
T2903 7186-7193 Positive_regulation denotes induced
T2904 7194-7199 Protein denotes IFN-γ
T2905 7200-7210 Gene_expression denotes expression
T2906 7234-7239 Protein denotes IL-10
T2907 7240-7250 Gene_expression denotes expression
T2908 7268-7273 Protein denotes IL-12
T2909 7303-7309 Positive_regulation denotes induce true true
T2910 7322-7327 Protein denotes IL-10
T2911 7328-7338 Gene_expression denotes production
T2912 7440-7445 Protein denotes IL-12
T2913 7478-7483 Protein denotes IL-10
T2914 7484-7493 Gene_expression denotes producing
T2915 7516-7524 Gene_expression denotes produced
T2916 7525-7529 Positive_regulation denotes more
T2917 7530-7535 Protein denotes IL-10
T2918 7619-7628 Gene_expression denotes producing
T2919 7629-7634 Protein denotes IL-10
T2920 7635-7643 Positive_regulation denotes required
T2921 7649-7654 Protein denotes IL-12
T2922 7710-7717 Gene_expression denotes produce
T2923 7710-7717 Gene_expression denotes produce
T2924 7735-7740 Protein denotes IL-10
T2925 7745-7750 Protein denotes IFN-γ
T2926 7755-7759 Negative_regulation denotes lost
T2927 7778-7785 Gene_expression denotes produce
T2928 7786-7790 Protein denotes IL-2
T2929 7828-7833 Protein denotes IL-12
T2930 7863-7866 Protein denotes CD4
T2931 7950-7955 Protein denotes IL-10
T2932 7956-7966 Gene_expression denotes production
T2933 7992-7997 Protein denotes IL-10
T2934 7998-8007 Gene_expression denotes producing
T2935 8044-8051 Negative_regulation denotes limited
T2936 8052-8056 Protein denotes IL-2
T2937 8064-8067 Protein denotes CD4
T2938 8090-8121 Protein denotes recombination-activating gene 1
T2939 8123-8127 Protein denotes Rag1
T2940 8129-8138 Negative_regulation denotes deficient
T2941 8203-8208 Protein denotes IL-12
T2942 8215-8223 Positive_regulation denotes resulted
T2943 8227-8232 Protein denotes IL-10
T2944 8233-8243 Gene_expression denotes expression
T2945 8295-8304 Positive_regulation denotes dependent true
T2946 8414-8419 Protein denotes TGF-β
T2947 8424-8430 Positive_regulation denotes induce true
T2948 8431-8436 Protein denotes IL-10
T2949 8440-8443 Protein denotes CD4
T2950 8593-8607 Negative_regulation denotes neutralization
T2951 8611-8616 Protein denotes TGF-β
T2952 8624-8633 Positive_regulation denotes increased
T2953 8634-8639 Protein denotes IL-10
T2954 8640-8650 Gene_expression denotes production
T2955 8712-8717 Protein denotes IL-10
T2956 8718-8727 Gene_expression denotes producing
T2957 8743-8751 Positive_regulation denotes depended true
T2958 8743-8751 Positive_regulation denotes depended
T2959 8743-8751 Positive_regulation denotes depended true
T2960 8771-8776 Protein denotes IL-12
T2961 8850-8854 Protein denotes IL-2
T2962 8858-8863 Protein denotes TGF-β
T4887 8907-8912 Protein denotes IL-10
T4888 8913-8923 Gene_expression denotes Production
T4889 8940-8949 Positive_regulation denotes Dependent true
T4890 8953-8958 Protein denotes STAT4
T4891 8970-8975 Protein denotes STAT6
T4892 8977-8982 Protein denotes IFN-γ
T4893 8987-8991 Protein denotes IL-4
T4894 9080-9089 Gene_expression denotes producing
T4895 9090-9095 Protein denotes IL-10
T4896 9117-9121 Regulation denotes role true
T4897 9125-9130 Protein denotes STAT4
T4898 9162-9171 Positive_regulation denotes activated
T4899 9175-9180 Protein denotes IL-12
T4900 9210-9213 Protein denotes CD4
T4901 9231-9240 Negative_regulation denotes deficient
T4902 9244-9249 Protein denotes STAT4
T4903 9305-9310 Protein denotes IL-12
T4904 9315-9318 Protein denotes OVA
T4905 9327-9332 Protein denotes IL-10
T4906 9333-9342 Gene_expression denotes producing
T4907 9417-9422 Protein denotes IL-12
T4908 9475-9482 Negative_regulation denotes absence
T4909 9486-9491 Protein denotes STAT4
T4910 9517-9527 Gene_expression denotes expressing
T4911 9528-9533 Protein denotes IFN-γ
T4912 9551-9561 Negative_regulation denotes diminished
T4913 9593-9601 Positive_regulation denotes increase
T4914 9593-9601 Positive_regulation denotes increase
T4915 9629-9639 Gene_expression denotes expressing true
T4916 9629-9639 Gene_expression denotes expressing
T4917 9640-9644 Protein denotes IL-4
T4918 9654-9659 Protein denotes IL-10
T4919 9689-9694 Protein denotes STAT4
T4920 9695-9706 Positive_regulation denotes contributes true
T4921 9710-9715 Protein denotes IL-10
T4922 9716-9726 Gene_expression denotes expression
T4923 9749-9754 Protein denotes IL-10
T4924 9755-9765 Gene_expression denotes expression
T4925 9788-9792 Protein denotes IL-4
T4926 9872-9877 Protein denotes IL-10
T4927 9878-9887 Gene_expression denotes producing
T4928 9932-9936 Protein denotes IL-4
T4929 9950-9955 Protein denotes STAT6
T4930 9956-9966 Positive_regulation denotes activation
T4931 10021-10028 Negative_regulation denotes absence
T4932 10032-10037 Protein denotes STAT6
T4933 10076-10081 Protein denotes IL-10
T4934 10082-10091 Gene_expression denotes producing
T4935 10102-10120 Positive_regulation denotes in the presence of
T4936 10102-10120 Positive_regulation denotes in the presence of
T4937 10121-10126 Protein denotes IL-12
T4938 10131-10134 Protein denotes OVA
T4939 10180-10185 Protein denotes STAT6
T4940 10186-10195 Negative_regulation denotes deficient
T4941 10225-10233 Gene_expression denotes produced
T4942 10225-10233 Gene_expression denotes produced
T4943 10239-10244 Protein denotes IL-10
T4944 10249-10254 Protein denotes IFN-γ
T4945 10363-10367 Negative_regulation denotes lack
T4946 10371-10376 Protein denotes STAT6
T4947 10377-10386 Negative_regulation denotes abrogated
T4948 10377-10386 Negative_regulation denotes abrogated
T4949 10392-10396 Protein denotes IL-4
T4950 10401-10406 Protein denotes IL-10
T4951 10407-10417 Gene_expression denotes production
T4952 10407-10417 Gene_expression denotes production
T4953 10444-10448 Protein denotes IL-4
T4954 10522-10527 Protein denotes STAT4
T4955 10539-10544 Protein denotes IL-10
T4956 10549-10553 Protein denotes IL-4
T4957 10554-10564 Gene_expression denotes production
T4958 10554-10564 Gene_expression denotes production
T4959 10594-10603 Positive_regulation denotes increased
T4960 10594-10603 Positive_regulation denotes increased
T4961 10686-10691 Protein denotes IL-10
T4962 10692-10702 Gene_expression denotes expression
T4981 11096-11103 Positive_regulation denotes induced
T4982 11130-11135 Protein denotes IL-12
T4983 11144-11152 Regulation denotes affected true
T4984 11159-11166 Negative_regulation denotes absence
T4985 11170-11175 Protein denotes IFN-γ
T4986 11206-11216 Gene_expression denotes expression
T4987 11220-11225 Protein denotes IL-10
T4988 11242-11253 Regulation denotes independent true
T4989 11257-11262 Protein denotes IFN-γ
T4990 11271-11278 Negative_regulation denotes absence
T4991 11282-11287 Protein denotes IFN-γ
T4992 11304-11312 Positive_regulation denotes increase
T4993 11320-11328 Localization denotes secreted
T4994 11329-11333 Protein denotes IL-4
T4995 11397-11401 Regulation denotes role true
T4996 11405-11409 Protein denotes IL-4
T4997 11442-11451 Gene_expression denotes producing
T4998 11452-11457 Protein denotes IL-10
T4999 11490-11494 Protein denotes IL-4
T5000 11495-11504 Negative_regulation denotes deficient
T5001 11511-11514 Protein denotes CD4
T5002 11529-11534 Protein denotes IL-12
T5003 11587-11594 Negative_regulation denotes absence
T5004 11598-11603 Protein denotes STAT6
T5005 11617-11621 Protein denotes IL-4
T5006 11622-11632 Negative_regulation denotes deficiency
T5007 11679-11688 Gene_expression denotes producing
T5008 11689-11694 Protein denotes IL-10
T5009 11753-11762 Gene_expression denotes producing
T5010 11763-11768 Protein denotes IL-10
T5011 11812-11817 Protein denotes IL-10
T5012 11818-11828 Gene_expression denotes production
T5013 11945-11950 Protein denotes STAT4
T5014 11971-11980 Positive_regulation denotes induction
T5015 11971-11980 Positive_regulation denotes induction
T5016 11984-11989 Protein denotes IL-10
T5017 11990-12000 Gene_expression denotes production
T5018 12018-12023 Protein denotes STAT6
T7000 12487-12490 Protein denotes OVA
T7001 12536-12543 Positive_regulation denotes induced
T7002 12536-12543 Positive_regulation denotes induced
T7003 12544-12549 Protein denotes IL-10
T7004 12554-12559 Protein denotes IFN-γ
T7005 12560-12570 Gene_expression denotes production
T7006 12560-12570 Gene_expression denotes production
T7007 12590-12595 Protein denotes IL-10
T7008 12596-12606 Gene_expression denotes production
T7009 12611-12619 Positive_regulation denotes enhanced
T7010 12696-12699 Protein denotes OVA
T7011 12756-12761 Protein denotes STAT4
T7012 12766-12771 Protein denotes STAT6
T7013 12812-12817 Protein denotes IL-10
T7014 12818-12827 Gene_expression denotes producing
T7015 12854-12859 Protein denotes STAT4
T7016 12864-12869 Protein denotes STAT6
T7017 12870-12879 Negative_regulation denotes deficient
T7018 12870-12879 Negative_regulation denotes deficient
T7019 12946-12949 Protein denotes OVA
T7020 12986-12996 Gene_expression denotes expression
T7021 12986-12996 Gene_expression denotes expression
T7022 13005-13010 Protein denotes IL-10
T7023 13015-13020 Protein denotes IFN-γ
T7024 13034-13041 Negative_regulation denotes reduced
T7025 13034-13041 Negative_regulation denotes reduced
T7026 13050-13070 Negative_regulation denotes completely abrogated true
T7027 13050-13070 Negative_regulation denotes completely abrogated true
T7028 13089-13094 Protein denotes STAT4
T7029 13237-13242 Protein denotes STAT6
T7030 13250-13256 Regulation denotes effect true
T7031 13260-13265 Protein denotes IL-10
T7032 13266-13276 Gene_expression denotes production
T7033 13362-13367 Protein denotes STAT6
T7034 13368-13377 Negative_regulation denotes deficient
T7861 13414-13424 Gene_expression denotes Production
T7862 13428-13438 Positive_regulation denotes Maintained
T7863 13471-13476 Protein denotes IL-12
T7864 13566-13571 Protein denotes IL-12
T7865 13580-13585 Protein denotes STAT4
T7866 13603-13612 Positive_regulation denotes induction
T7867 13616-13621 Protein denotes IL-10
T7868 13646-13649 Protein denotes CD4
T7869 13757-13762 Protein denotes IL-12
T7870 13813-13818 Protein denotes IL-12
T7871 13833-13839 Positive_regulation denotes induce
T7872 13848-13853 Protein denotes IL-10
T7873 13854-13864 Gene_expression denotes production
T7874 13949-13954 Protein denotes IL-10
T7875 13955-13964 Gene_expression denotes producing
T7876 14051-14056 Protein denotes IL-12
T7877 14057-14065 Positive_regulation denotes resulted
T7878 14073-14083 Gene_expression denotes production
T7879 14087-14092 Protein denotes IL-10
T7880 14171-14175 Positive_regulation denotes need
T7881 14180-14185 Protein denotes IL-12
T7882 14190-14195 Protein denotes IL-10
T7883 14196-14205 Positive_regulation denotes induction
T7884 14236-14241 Protein denotes IL-10
T7885 14242-14251 Positive_regulation denotes induction
T7886 14279-14288 Negative_regulation denotes abrogated
T7887 14294-14302 Protein denotes IL-12p40
T7888 14303-14312 Negative_regulation denotes deficient
T7889 14354-14359 Protein denotes IL-12
T7890 14363-14372 Positive_regulation denotes essential
T7891 14433-14443 Gene_expression denotes production
T7892 14447-14452 Protein denotes IL-10
T7893 14518-14523 Protein denotes IL-10
T7894 14524-14533 Gene_expression denotes producing
T7895 14563-14566 Protein denotes CD4
T7896 14627-14632 Protein denotes IL-12
T7897 14772-14777 Protein denotes IL-12
T7898 14801-14808 Positive_regulation denotes induced
T7899 14830-14837 Gene_expression denotes produce
T7900 14838-14843 Protein denotes IL-10
T7901 14883-14888 Protein denotes IL-12
T7902 14889-14893 Negative_regulation denotes lost
T7903 14911-14918 Gene_expression denotes express
T7904 14919-14924 Protein denotes IL-10
T7905 14959-14962 Protein denotes OVA
T7906 14979-14990 Negative_regulation denotes compensated
T7907 15015-15023 Positive_regulation denotes addition
T7908 15027-15032 Protein denotes IL-12
T7909 15111-15116 Protein denotes IL-12
T7910 15125-15134 Positive_regulation denotes cooperate true
T7911 15143-15152 Gene_expression denotes induction
T7912 15156-15161 Protein denotes IL-10
T7913 15180-15183 Protein denotes CD4
T7914 15237-15242 Protein denotes IL-12
T7915 15284-15292 Gene_expression denotes produced
T7916 15284-15292 Gene_expression denotes produced true
T7917 15309-15314 Protein denotes IFN-γ
T7918 15326-15331 Protein denotes IL-10
T7919 15351-15358 Positive_regulation denotes induced
T7920 15362-15369 Gene_expression denotes produce
T7921 15370-15375 Protein denotes IL-10
T7922 15408-15413 Protein denotes IL-12
T7923 15492-15497 Protein denotes IL-12
T7924 15530-15539 Positive_regulation denotes induction
T7925 15543-15548 Protein denotes IL-10
T7926 15549-15559 Gene_expression denotes production
T9274 15605-15613 Positive_regulation denotes Requires
T9275 15605-15613 Positive_regulation denotes Requires
T9276 15614-15618 Protein denotes ERK1
T9277 15623-15627 Protein denotes ERK2
T9278 15628-15638 Positive_regulation denotes Activation
T9279 15628-15638 Positive_regulation denotes Activation
T9280 15664-15675 Positive_regulation denotes maintenance
T9281 15679-15684 Protein denotes IL-10
T9282 15685-15694 Gene_expression denotes induction
T9283 15708-15716 Positive_regulation denotes required
T9284 15806-15814 Positive_regulation denotes addition
T9285 15818-15823 Protein denotes IL-12
T9286 15878-15885 Positive_regulation denotes induced
T9287 15878-15885 Positive_regulation denotes induced
T9288 15895-15899 Protein denotes ERK1
T9289 15904-15908 Protein denotes ERK2
T9290 15909-15919 Positive_regulation denotes activation
T9291 15909-15919 Positive_regulation denotes activation
T9292 15930-15937 Positive_regulation denotes induced
T9293 15930-15937 Positive_regulation denotes induced
T9294 15977-15980 Protein denotes CD4
T9295 16071-16074 Protein denotes CD4
T9296 16192-16196 Protein denotes ERK1
T9297 16201-16205 Protein denotes ERK2
T9298 16206-16216 Positive_regulation denotes activation
T9299 16206-16216 Positive_regulation denotes activation
T9300 16341-16349 Positive_regulation denotes enhanced
T9301 16341-16349 Positive_regulation denotes enhanced
T9302 16354-16363 Positive_regulation denotes prolonged
T9303 16354-16363 Positive_regulation denotes prolonged
T9304 16364-16368 Protein denotes ERK1
T9305 16373-16377 Protein denotes ERK2
T9306 16378-16388 Positive_regulation denotes activation
T9307 16378-16388 Positive_regulation denotes activation
T9308 16408-16413 Protein denotes IL-12
T9309 16532-16536 Protein denotes ERK1
T9310 16541-16545 Protein denotes ERK2
T9311 16546-16556 Positive_regulation denotes activation
T9312 16546-16556 Positive_regulation denotes activation
T9313 16561-16569 Positive_regulation denotes required true
T9314 16561-16569 Positive_regulation denotes required true
T9315 16578-16587 Positive_regulation denotes induction
T9316 16591-16596 Protein denotes IL-10
T9317 16866-16869 Protein denotes CD3
T9318 16895-16900 Protein denotes IL-12
T9319 16972-16977 Protein denotes IL-12
T9320 17013-17022 Gene_expression denotes producing
T9321 17013-17022 Gene_expression denotes producing
T9322 17028-17033 Protein denotes IL-10
T9323 17038-17043 Protein denotes IFN-γ
T9324 17115-17124 Negative_regulation denotes abrogated
T9325 17129-17139 Gene_expression denotes production
T9326 17143-17148 Protein denotes IL-10
T9327 17170-17173 Protein denotes CD3
T9328 17201-17209 Negative_regulation denotes inhibits
T9329 17201-17209 Negative_regulation denotes inhibits
T9330 17201-17209 Negative_regulation denotes inhibits
T9331 17201-17209 Negative_regulation denotes inhibits
T9332 17201-17209 Negative_regulation denotes inhibits
T9333 17214-17218 Protein denotes MEK5
T9334 17219-17228 Positive_regulation denotes catalyzed
T9335 17229-17239 Positive_regulation denotes activation
T9336 17243-17247 Protein denotes ERK5
T9337 17264-17268 Protein denotes MEK1
T9338 17274-17278 Protein denotes MEK2
T9339 17279-17288 Positive_regulation denotes catalyzed
T9340 17279-17288 Positive_regulation denotes catalyzed
T9341 17279-17288 Positive_regulation denotes catalyzed
T9342 17279-17288 Positive_regulation denotes catalyzed
T9343 17289-17299 Positive_regulation denotes activation
T9344 17289-17299 Positive_regulation denotes activation
T9345 17303-17307 Protein denotes ERK1
T9346 17312-17316 Protein denotes ERK2
T9347 17412-17416 Protein denotes MEK1
T9348 17421-17425 Protein denotes MEK2
T9349 17426-17435 Negative_regulation denotes inhibitor
T9350 17426-17435 Negative_regulation denotes inhibitor
T9351 17475-17483 Negative_regulation denotes inhibits true
T9352 17475-17483 Negative_regulation denotes inhibits
T9353 17475-17483 Negative_regulation denotes inhibits
T9354 17484-17488 Protein denotes MEK1
T9355 17493-17497 Protein denotes MEK2
T9356 17506-17510 Protein denotes MEK5
T9357 17577-17587 Negative_regulation denotes inhibition
T9358 17591-17596 Protein denotes IL-10
T9359 17597-17607 Gene_expression denotes production
T9360 17746-17754 Protein denotes p38 MAPK
T9361 17755-17764 Negative_regulation denotes inhibitor
T9362 17783-17788 Protein denotes GSK3β
T9363 17789-17798 Negative_regulation denotes inhibitor
T9364 17832-17838 Regulation denotes effect true
T9365 17832-17838 Regulation denotes effect true
T9366 17842-17847 Protein denotes IL-10
T9367 17848-17858 Gene_expression denotes production
T9368 17915-17920 Protein denotes IL-10
T9369 17921-17931 Gene_expression denotes production
T9370 17945-17959 Positive_regulation denotes in response to
T9371 17982-17987 Protein denotes IL-12
T9372 17988-17996 Positive_regulation denotes requires true true
T9373 17988-17996 Positive_regulation denotes requires true true
T9374 17997-18001 Protein denotes ERK1
T9375 18006-18010 Protein denotes ERK2
T9376 18034-18044 Positive_regulation denotes activation
T9377 18034-18044 Positive_regulation denotes activation
T9378 18052-18055 Protein denotes p38
T9379 18063-18068 Protein denotes GSK3β
T10973 18080-18085 Protein denotes IL-10
T10974 18086-18096 Gene_expression denotes Production
T10975 18124-18132 Positive_regulation denotes Requires
T10976 18124-18132 Positive_regulation denotes Requires
T10977 18133-18137 Protein denotes ERK1
T10978 18142-18146 Protein denotes ERK2
T10979 18147-18157 Positive_regulation denotes Activation
T10980 18147-18157 Positive_regulation denotes Activation
T10981 18177-18182 Protein denotes IL-10
T10982 18183-18193 Gene_expression denotes production
T10983 18225-18234 Positive_regulation denotes dependent true
T10984 18225-18234 Positive_regulation denotes dependent true
T10985 18238-18242 Protein denotes ERK1
T10986 18247-18251 Protein denotes ERK2
T10987 18252-18262 Positive_regulation denotes activation
T10988 18252-18262 Positive_regulation denotes activation
T10989 18304-18307 Protein denotes CD3
T10990 18317-18321 Protein denotes CD28
T10991 18451-18454 Protein denotes MEK
T10992 18455-18464 Negative_regulation denotes inhibitor
T10993 18492-18496 Protein denotes ERK1
T10994 18501-18505 Protein denotes ERK2
T10995 18506-18516 Positive_regulation denotes activation
T10996 18506-18516 Positive_regulation denotes activation
T10997 18537-18545 Positive_regulation denotes required
T10998 18537-18545 Positive_regulation denotes required
T10999 18550-18559 Gene_expression denotes induction
T11000 18563-18568 Protein denotes IL-10
T11001 18606-18611 Protein denotes IL-10
T11002 18612-18622 Gene_expression denotes production
T11003 18663-18672 Negative_regulation denotes inhibited
T11004 18696-18699 Protein denotes MEK
T11005 18700-18709 Negative_regulation denotes inhibitor
T11006 18762-18772 Negative_regulation denotes inhibitors
T11007 18762-18772 Negative_regulation denotes inhibitors
T11008 18776-18784 Protein denotes p38 MAPK
T11009 18791-18797 Protein denotes GSK-3β
T11010 18798-18808 Positive_regulation denotes activation
T11011 18798-18808 Positive_regulation denotes activation
T11012 18817-18823 Regulation denotes affect true
T11013 18817-18823 Regulation denotes affect true
T11014 18828-18838 Gene_expression denotes expression
T11015 18842-18847 Protein denotes IL-10
T11016 18897-18901 Protein denotes ERK1
T11017 18906-18910 Protein denotes ERK2
T11018 18951-18962 Positive_regulation denotes requirement
T11019 18971-18980 Positive_regulation denotes induction
T11020 18984-18989 Protein denotes IL-10
T11021 18990-19000 Gene_expression denotes production
T11841 19064-19069 Protein denotes IL-10
T11842 19070-19080 Gene_expression denotes Production
T11843 19167-19177 Regulation denotes regulating
T11844 19178-19183 Protein denotes IL-10
T11845 19184-19194 Gene_expression denotes production
T11846 19222-19225 Protein denotes CD4
T11847 19260-19263 Protein denotes OVA
T11848 19295-19300 Protein denotes IL-12
T11849 19409-19417 Positive_regulation denotes resulted
T11850 19421-19434 Transcription denotes transcription
T11851 19438-19441 Protein denotes Il4
T11852 19455-19464 Negative_regulation denotes abrogated
T11853 19496-19501 Protein denotes IL-12
T11854 19531-19544 Transcription denotes transcription
T11855 19548-19552 Protein denotes Ifnγ
T11856 19557-19564 Positive_regulation denotes induced
T11857 19568-19573 Protein denotes IL-12
T11858 19632-19643 Positive_regulation denotes this effect
T11859 19647-19652 Protein denotes IL-12
T11860 19666-19677 Positive_regulation denotes upregulated
T11861 19740-19744 Protein denotes Il10
T11862 19745-19758 Transcription denotes transcription
T11863 19809-19812 Protein denotes Il4
T11864 19813-19823 Gene_expression denotes expression
T11865 19858-19867 Negative_regulation denotes abrogated
T11866 19858-19867 Negative_regulation denotes abrogated
T11867 19905-19908 Protein denotes Il4
T11868 19909-19919 Gene_expression denotes expression
T11869 19958-19963 Protein denotes IL-12
T11870 19975-19981 Regulation denotes effect true
T11871 19985-19993 Positive_regulation denotes increase
T11872 19994-19999 Protein denotes IL-10
T11873 20000-20015 Transcription denotes mRNA expression
T11874 20083-20088 Protein denotes IL-12
T11875 20089-20096 Positive_regulation denotes induced
T11876 20089-20096 Positive_regulation denotes induced
T11877 20114-20118 Protein denotes Il10
T11878 20119-20132 Transcription denotes transcription
T11879 20144-20148 Protein denotes Ifnγ
T11880 20149-20159 Gene_expression denotes expression
T11881 20254-20257 Protein denotes CD4
T11882 20323-20330 Transcription denotes express true
T11883 20347-20353 Protein denotes Tbx-21
T11884 20355-20360 Protein denotes T-bet
T11885 20401-20406 Protein denotes IL-12
T11886 20449-20455 Protein denotes GATA-3
T11887 20456-20471 Transcription denotes mRNA expression
T11888 20598-20611 Negative_regulation denotes downregulated
T11889 20661-20666 Protein denotes IL-12
T11890 20730-20733 Positive_regulation denotes led
T11891 20737-20747 Gene_expression denotes expression
T11892 20751-20756 Protein denotes c-maf
T11893 20842-20851 Negative_regulation denotes abrogated
T11894 20911-20916 Protein denotes IL-12
T11895 20917-20926 Positive_regulation denotes sustained
T11896 20936-20946 Transcription denotes expression
T11897 20950-20955 Protein denotes c-Maf
T11898 21017-21022 Protein denotes IL-12
T11899 21023-21034 Positive_regulation denotes maintenance
T11900 21038-21043 Protein denotes c-maf
T11901 21044-21054 Gene_expression denotes expression
T11902 21055-21063 Positive_regulation denotes required
T11903 21064-21069 Protein denotes STAT4
T11904 21070-21080 Positive_regulation denotes activation
T11905 21118-21127 Transcription denotes expressed
T11906 21118-21127 Transcription denotes expressed
T11907 21128-21134 Protein denotes IL-17a
T11908 21146-21151 Protein denotes IL-10
T11909 21170-21175 Protein denotes T-bet
T11910 21180-21186 Protein denotes GATA-3
T11911 21187-21191 Transcription denotes mRNA
T11912 21187-21191 Transcription denotes mRNA
T11913 21197-21209 Negative_regulation denotes undetectable
T11914 21197-21209 Negative_regulation denotes undetectable
T11915 21244-21250 Protein denotes ROR-γt
T11916 21255-21259 Positive_regulation denotes high
T11917 21311-21320 Gene_expression denotes expressed
T11918 21337-21342 Protein denotes c-maf
T11919 21407-21412 Protein denotes c-Maf
T11920 21426-21435 Gene_expression denotes expressed
T11921 21443-21448 Protein denotes IL-10
T11922 21449-21459 Gene_expression denotes expressing
T11923 21633-21637 Protein denotes Il10
T11924 21638-21648 Gene_expression denotes expression
T11925 21650-21655 Protein denotes c-maf
T11926 21656-21666 Gene_expression denotes expression
T11927 21671-21680 Negative_regulation denotes inhibited
T11928 21671-21680 Negative_regulation denotes inhibited
T11929 21671-21680 Negative_regulation denotes inhibited
T11930 21671-21680 Negative_regulation denotes inhibited
T11931 21726-21730 Protein denotes MEK1
T11932 21735-21739 Protein denotes MEK2
T11933 21740-21749 Negative_regulation denotes inhibitor
T11934 21740-21749 Negative_regulation denotes inhibitor
T11942 21808-21816 Regulation denotes affected true
T13969 22481-22486 Protein denotes IL-12
T13970 22487-22494 Positive_regulation denotes induced
T13971 22495-22501 Protein denotes STAT-4
T13972 22502-22512 Positive_regulation denotes activation
T13973 22516-22523 Gene_expression denotes produce
T13974 22524-22529 Protein denotes IL-10
T13975 22549-22553 Protein denotes ERK1
T13976 22558-22562 Protein denotes ERK2
T13977 22563-22573 Positive_regulation denotes activation
T13978 22563-22573 Positive_regulation denotes activation
T13979 22595-22603 Positive_regulation denotes required
T13980 22595-22603 Positive_regulation denotes required
T13981 22612-22622 Gene_expression denotes production
T13982 22626-22631 Protein denotes IL-10
T13983 22723-22728 Protein denotes IL-10
T13984 22729-22770 Regulation denotes provides a highly regulated feedback loop
T13985 23107-23112 Protein denotes IL-10
T13986 23362-23369 Positive_regulation denotes induced
T13987 23373-23380 Gene_expression denotes express
T13988 23397-23402 Protein denotes IL-10
T13989 23433-23438 Protein denotes IL-10
T13990 23439-23448 Gene_expression denotes producing
T13991 23473-23476 Protein denotes CD4
T13992 23702-23707 Protein denotes IL-10
T13993 23721-23726 Protein denotes Foxp3
T13994 23743-23752 Gene_expression denotes coproduce
T13995 23743-23752 Gene_expression denotes coproduce
T13996 23753-23758 Protein denotes IL-10
T13997 23763-23768 Protein denotes IFN-γ
T13998 23879-23884 Protein denotes Foxp3
T13999 23939-23944 Protein denotes IL-10
T14000 23945-23955 Gene_expression denotes production
T14001 24063-24066 Protein denotes CD4
T14002 24076-24085 Gene_expression denotes producing
T14003 24086-24091 Protein denotes IL-10
T14004 24325-24328 Protein denotes CD4
T14005 24374-24379 Protein denotes IL-12
T14006 24451-24461 Gene_expression denotes expressing
T14007 24451-24461 Gene_expression denotes expressing
T14008 24479-24484 Protein denotes IFN-γ
T14009 24489-24494 Protein denotes IL-10
T14010 24496-24500 Negative_regulation denotes lose
T14011 24507-24511 Protein denotes IL-2
T14012 24512-24522 Gene_expression denotes expression
T14013 24627-24631 Negative_regulation denotes loss
T14014 24635-24639 Protein denotes IL-2
T14015 24658-24668 Gene_expression denotes production
T14016 24672-24677 Protein denotes IL-10
T14017 24893-24898 Protein denotes IL-10
T14018 24972-24975 Protein denotes OVA
T14019 25018-25027 Positive_regulation denotes induction
T14020 25031-25036 Protein denotes IL-10
T14021 25089-25096 Negative_regulation denotes reduced
T14022 25100-25105 Protein denotes STAT4
T14023 25106-25115 Negative_regulation denotes deficient
T14024 25353-25364 Positive_regulation denotes requirement
T14025 25369-25374 Protein denotes IL-12
T14026 25382-25391 Positive_regulation denotes induction
T14027 25395-25400 Protein denotes IL-10
T14028 25534-25543 Gene_expression denotes producing
T14029 25544-25549 Protein denotes IL-10
T14030 25556-25561 Protein denotes IL-12
T14031 25580-25585 Protein denotes IL-10
T14032 25586-25596 Gene_expression denotes production
T14033 25610-25617 Positive_regulation denotes induced
T14034 25643-25648 Protein denotes IL-12
T14035 25653-25664 Regulation denotes independent true
T14036 25668-25673 Protein denotes IFN-γ
T14037 25754-25759 Protein denotes IFN-γ
T14038 25763-25772 Positive_regulation denotes mediating true
T14039 25773-25778 Protein denotes IL-10
T14040 25779-25791 Positive_regulation denotes reactivation
T14041 25906-25909 Protein denotes CD4
T14042 25960-25967 Gene_expression denotes express true
T14043 25968-25973 Protein denotes IL-10
T14044 26005-26012 Positive_regulation denotes induced
T14045 26016-26023 Gene_expression denotes produce
T14046 26024-26029 Protein denotes IL-10
T14047 26117-26122 Protein denotes IL-12
T14048 26141-26150 Positive_regulation denotes dependent
T14049 26158-26167 Positive_regulation denotes induction
T14050 26171-26176 Protein denotes IL-12
T14051 26250-26255 Protein denotes IL-12
T14052 26256-26264 Positive_regulation denotes resulted
T14053 26290-26295 Protein denotes IL-10
T14054 26296-26306 Gene_expression denotes production
T14055 26346-26350 Protein denotes ERK1
T14056 26355-26359 Protein denotes ERK2
T14057 26360-26370 Positive_regulation denotes activation
T14058 26360-26370 Positive_regulation denotes activation
T14059 26376-26385 Positive_regulation denotes increased
T14060 26386-26396 Gene_expression denotes expression
T14061 26400-26405 Protein denotes IFN-γ
T14062 26447-26453 Positive_regulation denotes induce
T14063 26454-26463 Positive_regulation denotes increased
T14064 26464-26469 Protein denotes IL-12
T14065 26470-26480 Gene_expression denotes production
T14066 26555-26565 Positive_regulation denotes upregulate true
T14067 26566-26571 Protein denotes IL-12
T14068 26572-26582 Gene_expression denotes production
T14069 26669-26680 Positive_regulation denotes requirement
T14070 26685-26690 Protein denotes IFN-γ
T14071 26694-26700 Positive_regulation denotes induce
T14072 26701-26706 Protein denotes IL-10
T14073 26725-26737 Positive_regulation denotes upregulation
T14074 26741-26746 Protein denotes IL-12
T14075 26769-26776 Positive_regulation denotes induced
T14076 26777-26782 Protein denotes IL-10
T14077 26810-26815 Protein denotes IL-10
T14078 26838-26847 Regulation denotes regulated
T14079 27053-27058 Protein denotes OX-40
T14080 27086-27105 Negative_regulation denotes negatively regulate
T14081 27106-27111 Protein denotes IL-10
T14082 27112-27122 Gene_expression denotes production
T14083 27177-27181 Protein denotes ICOS
T14084 27214-27220 Positive_regulation denotes induce true
T14085 27221-27226 Protein denotes IL-10
T14086 27318-27322 Protein denotes ICOS
T14087 27338-27347 Regulation denotes regulates
T14088 27348-27352 Protein denotes IL-4
T14089 27353-27363 Gene_expression denotes production
T14090 27445-27449 Protein denotes ERK1
T14091 27454-27458 Protein denotes ERK2
T14092 27459-27469 Positive_regulation denotes activation
T14093 27459-27469 Positive_regulation denotes activation
T14094 27478-27488 Regulation denotes regulation
T14095 27478-27488 Regulation denotes regulation
T14096 27492-27497 Protein denotes IL-10
T14097 27498-27508 Gene_expression denotes production
T14098 27666-27671 Protein denotes IL-10
T14099 27730-27738 Gene_expression denotes produced
T14100 27752-27761 Regulation denotes regulated
T14101 27818-27822 Regulation denotes role
T14102 27818-27822 Regulation denotes role
T14103 27827-27831 Protein denotes ERK1
T14104 27836-27840 Protein denotes ERK2
T14105 27841-27851 Positive_regulation denotes activation
T14106 27841-27851 Positive_regulation denotes activation
T14107 27859-27868 Positive_regulation denotes induction
T14108 27872-27877 Protein denotes IL-10
T14109 27878-27888 Gene_expression denotes production
T14110 28013-28023 Regulation denotes regulation
T14111 28027-28032 Protein denotes IL-10
T14115 28284-28292 Gene_expression denotes produced
T14116 28329-28339 Gene_expression denotes expression
T14117 28360-28370 Gene_expression denotes expression
T14118 28374-28379 Protein denotes T-bet
T14119 28396-28401 Protein denotes IFN-γ
T14120 28402-28412 Gene_expression denotes production
T14121 28486-28491 Protein denotes IL-12
T14122 28506-28514 Positive_regulation denotes required
T14123 28506-28514 Positive_regulation denotes required
T14124 28519-28524 Protein denotes IL-10
T14125 28529-28534 Protein denotes IFN-γ
T14126 28535-28545 Gene_expression denotes expression
T14127 28535-28545 Gene_expression denotes expression
T14128 28575-28586 Positive_regulation denotes maintenance
T14129 28590-28595 Protein denotes IL-10
T14130 28596-28606 Gene_expression denotes expression
T14131 28610-28621 Positive_regulation denotes conditional
T14132 28610-28621 Positive_regulation denotes conditional
T14133 28625-28630 Protein denotes IL-12
T14134 28634-28638 Protein denotes IL-4
T14135 28650-28655 Protein denotes IL-10
T14136 28677-28683 Protein denotes GATA-3
T14137 28728-28733 Protein denotes IL-10
T14138 28780-28785 Protein denotes IL-10
T14139 28786-28794 Gene_expression denotes produced
T14140 28894-28899 Protein denotes IL-12
T14141 28912-28924 Negative_regulation denotes downregulate
T14142 28925-28931 Protein denotes Gata-3
T14143 28932-28942 Gene_expression denotes expression
T14144 28995-29001 Positive_regulation denotes induce true
T14145 29002-29007 Protein denotes IL-10
T14146 29008-29018 Gene_expression denotes expression
T14147 29053-29063 Gene_expression denotes Expression
T14148 29067-29072 Protein denotes c-maf
T14149 29085-29095 Negative_regulation denotes diminished
T14150 29154-29164 Positive_regulation denotes maintained
T14151 29168-29173 Protein denotes IL-12
T14152 29206-29211 Protein denotes c-maf
T14153 29212-29222 Gene_expression denotes expression
T14154 29236-29241 Protein denotes IL-10
T14155 29242-29251 Gene_expression denotes producing
T14156 29287-29292 Protein denotes IL-10
T14157 29297-29306 Positive_regulation denotes dependent
T14158 29297-29306 Positive_regulation denotes dependent
T14159 29310-29313 Protein denotes ERK
T14160 29314-29324 Positive_regulation denotes activation
T14161 29355-29365 Gene_expression denotes expression
T14162 29389-29394 Protein denotes c-Maf
T14163 29419-29428 Positive_regulation denotes essential
T14164 29454-29459 Protein denotes IL-10
T14165 29460-29470 Gene_expression denotes expression
T14166 29559-29562 Protein denotes CD4
T14167 29664-29671 Positive_regulation denotes induced
T14168 29675-29679 Gene_expression denotes make
T14169 29680-29685 Protein denotes IL-10
T14170 29687-29691 Protein denotes ERK1
T14171 29696-29700 Protein denotes ERK2
T14172 29701-29711 Positive_regulation denotes activation
T14173 29701-29711 Positive_regulation denotes activation
T14174 29715-29723 Positive_regulation denotes required
T14175 29715-29723 Positive_regulation denotes required
T14176 29728-29733 Protein denotes IL-10
T14177 29734-29744 Gene_expression denotes production
T14178 29794-29804 Gene_expression denotes expression
T14179 29808-29813 Protein denotes IL-10
T14180 29865-29870 Protein denotes IL-10
T14181 29871-29881 Gene_expression denotes expression
T14182 29885-29892 Positive_regulation denotes induced
T14183 29902-29911 Positive_regulation denotes amplified
T14184 29916-29925 Regulation denotes regulated
T14185 29955-29960 Protein denotes IL-12
T14186 30129-30137 Regulation denotes regulate
T14187 30142-30152 Gene_expression denotes production
T14188 30156-30161 Protein denotes IL-10
T14189 30350-30360 Regulation denotes regulation
T14190 30364-30369 Protein denotes IL-10
T14191 30370-30380 Gene_expression denotes production
T18672 30650-30653 Protein denotes OVA
T18673 30691-30695 Protein denotes Rag1
T18674 30698-30702 Protein denotes IL-4
T18675 30705-30710 Protein denotes IFN-γ
T18676 30713-30718 Protein denotes STAT4
T18677 30725-30730 Protein denotes STAT6
T18678 30731-30740 Negative_regulation denotes deficient
T18679 30731-30740 Negative_regulation denotes deficient
T18680 30731-30740 Negative_regulation denotes deficient
T18681 30731-30740 Negative_regulation denotes deficient
T18682 30731-30740 Negative_regulation denotes deficient
T18683 31477-31486 Protein denotes ovalbumin
T18684 31496-31499 Protein denotes OVA
T18685 31542-31551 Protein denotes ovalbumin
T18686 31660-31663 Protein denotes MEK
T18687 31664-31674 Negative_regulation denotes inhibitors
T18688 31687-31690 Protein denotes p38
T18689 31691-31700 Negative_regulation denotes inhibitor
T18690 31716-31721 Protein denotes GSK3β
T18691 31722-31731 Negative_regulation denotes inhibitor
T19122 32666-32669 Protein denotes CD3
T19123 32679-32683 Protein denotes CD28
T19124 33176-33179 Protein denotes MEK
T19125 33180-33190 Negative_regulation denotes inhibitors
T19126 33203-33206 Protein denotes p38
T19127 33207-33216 Negative_regulation denotes inhibitor
T19128 33228-33233 Protein denotes GSK3β
T19129 33234-33243 Negative_regulation denotes inhibitor
T20235 34095-34099 Protein denotes STAT
T20236 34100-34109 Negative_regulation denotes deficient
T20237 34180-34183 Protein denotes OVA
T20238 34362-34365 Protein denotes OVA
T20239 34565-34571 Protein denotes KJ1-26
T20240 34584-34587 Protein denotes CD4
T20241 34610-34615 Protein denotes IFN-γ
T20242 34620-34625 Protein denotes IL-10
T19934 33480-33483 Protein denotes CD3
T19935 33503-33507 Protein denotes CD28
T19936 33842-33846 Protein denotes IL-4
T19937 33848-33853 Protein denotes IL-10
T19938 33859-33864 Protein denotes IFN-γ
T20865 35269-35272 Protein denotes CD4
T20866 35496-35499 Protein denotes ERK
T20867 35504-35509 Protein denotes actin
T11839 19031-19036 Protein denotes c-maf
T11840 19037-19047 Gene_expression denotes Expression
T11935 21770-21775 Protein denotes T-bet
T11936 21780-21785 Protein denotes RORγt
T11937 21786-21796 Gene_expression denotes expression
T11938 21786-21796 Gene_expression denotes expression
T11939 21808-21816 Regulation denotes affected true
T11940 21808-21816 Regulation denotes affected true
T11941 21808-21816 Regulation denotes affected true
T2860 5900-5905 Protein denotes IL-12
T2861 5968-5977 Gene_expression denotes Producing
T2862 5978-5983 Protein denotes IL-10
T2863 6026-6037 Gene_expression denotes coproducing
T2864 6026-6037 Gene_expression denotes coproducing
T2865 6038-6043 Protein denotes IFN-γ
T2866 6048-6053 Protein denotes IL-10
T2867 6105-6108 Protein denotes CD4
T2868 6168-6177 Protein denotes ovalbumin
T1014 1256-1267 Protein denotes erleukin-10
T1015 1269-1274 Protein denotes IL-10
T1016 1410-1415 Protein denotes IL-10
T1017 1687-1692 Protein denotes IL-10
T1018 1696-1705 Gene_expression denotes expressed
T1019 2244-2247 Protein denotes CD4
T1020 2253-2256 Protein denotes CD8
T1021 2282-2285 Protein denotes CD4
T1022 2300-2307 Gene_expression denotes produce
T1023 2300-2307 Gene_expression denotes produce
T1024 2313-2325 Protein denotes interferon-γ
T1025 2327-2332 Protein denotes IFN-γ
T1026 2338-2343 Protein denotes IL-10
T1027 2423-2428 Protein denotes IL-12
T1028 2569-2580 Gene_expression denotes coproducing
T4963 10716-10724 Positive_regulation denotes depended true
T4964 10728-10733 Protein denotes STAT6
T4965 10746-10751 Protein denotes STAT4
T4966 10811-10820 Negative_regulation denotes inability
T4967 10824-10829 Protein denotes STAT4
T4968 10830-10839 Negative_regulation denotes deficient
T4969 10851-10858 Gene_expression denotes produce
T4970 10859-10864 Protein denotes IL-10
T4971 10874-10877 Positive_regulation denotes due true
T4972 10885-10892 Negative_regulation denotes absence
T4973 10896-10901 Protein denotes IFN-γ
T4974 10981-10986 Protein denotes IFN-γ
T4975 10987-10996 Negative_regulation denotes deficient
T4976 11003-11006 Protein denotes CD4
T4977 11035-11040 Protein denotes IL-12
T4978 11065-11068 Protein denotes OVA
T4979 11074-11083 Localization denotes secretion
T4980 11087-11092 Protein denotes IL-10
T20624 34797-34800 Protein denotes CD3
T20625 34821-34825 Protein denotes CD28
T20626 35193-35202 Protein denotes ubiquitin
T20627 35206-35210 Protein denotes HPRT
T20628 35211-35222 Transcription denotes mRNA levels
T20629 35211-35222 Transcription denotes mRNA levels
T13953 21842-21847 Protein denotes IL-10
T13954 21848-21858 Gene_expression denotes expression
T13955 22039-22044 Protein denotes IL-10
T13956 22045-22055 Gene_expression denotes expression
T13957 22184-22189 Protein denotes IL-10
T13958 22197-22205 Gene_expression denotes produced
T13959 22219-22233 Positive_regulation denotes in response to true
T13960 22347-22354 Gene_expression denotes produce
T13961 22355-22360 Protein denotes IL-10
T13962 22412-22420 Positive_regulation denotes required
T13963 22412-22420 Positive_regulation denotes required
T13964 22412-22420 Positive_regulation denotes required
T13965 22447-22451 Protein denotes ERK1
T13966 22456-22460 Protein denotes ERK2
T13967 22461-22476 Phosphorylation denotes phosphorylation
T13968 22461-22476 Phosphorylation denotes phosphorylation
T14112 28128-28135 Protein denotes histone
T14113 28155-28160 Protein denotes IL-10
T14114 28275-28280 Protein denotes IL-10
T9270 15575-15580 Protein denotes IL-10
T9271 15581-15591 Gene_expression denotes Production
T9272 15605-15613 Positive_regulation denotes Requires
T9273 15605-15613 Positive_regulation denotes Requires
T101 63-70 Positive_regulation denotes Induced
T102 71-76 Protein denotes STAT4
T103 102-105 Protein denotes ERK
T104 117-127 Positive_regulation denotes Activation
T105 168-171 Protein denotes CD4
T106 181-190 Gene_expression denotes producing
T107 181-190 Gene_expression denotes producing
T108 191-205 Protein denotes interleukin-10
T109 207-212 Protein denotes IL-10
T110 218-230 Protein denotes interferon-γ
T111 232-237 Protein denotes IFN-γ
T112 327-332 Protein denotes IL-10
T113 333-342 Gene_expression denotes producing
T114 411-416 Protein denotes IL-10
T115 417-426 Gene_expression denotes producing
T116 493-497 Protein denotes ERK1
T117 502-506 Protein denotes ERK2
T118 519-534 Phosphorylation denotes phosphorylation
T119 519-534 Phosphorylation denotes phosphorylation
T120 540-545 Protein denotes IL-12
T121 546-553 Positive_regulation denotes induced
T122 554-559 Protein denotes STAT4
T123 581-591 Positive_regulation denotes activation
T124 624-632 Positive_regulation denotes enhanced
T125 633-638 Protein denotes IL-10
T126 639-649 Gene_expression denotes production
T127 678-683 Protein denotes IL-12
T128 724-732 Positive_regulation denotes required
T129 772-777 Protein denotes IL-10
T130 778-787 Gene_expression denotes producing
T131 901-911 Positive_regulation denotes activation
T132 901-911 Positive_regulation denotes activation
T133 915-919 Protein denotes ERK1
T134 924-928 Protein denotes ERK2
T135 942-953 Positive_regulation denotes requirement
T136 942-953 Positive_regulation denotes requirement
T137 958-968 Gene_expression denotes production
T138 972-977 Protein denotes IL-10
T139 1002-1007 Protein denotes IL-10
T140 1008-1018 Gene_expression denotes expression
T141 1040-1045 Protein denotes c-maf
T142 1046-1056 Gene_expression denotes expression
T143 1221-1226 Protein denotes IL-10
T144 1227-1237 Gene_expression denotes production
T6993 12063-12068 Protein denotes STAT4
T6994 12112-12117 Protein denotes IL-10
T6995 12118-12127 Gene_expression denotes Producing
T6996 12164-12174 Regulation denotes regulating
T6997 12175-12180 Protein denotes IL-10
T6998 12181-12191 Gene_expression denotes production
T6999 12323-12326 Protein denotes OVA
T19107 31818-31821 Protein denotes CD4
T19108 31927-31930 Protein denotes CD4
T19109 31931-31936 Protein denotes CD62L
T19110 31940-31943 Protein denotes CD4
T19111 31944-31949 Protein denotes CD62L
T19112 31951-31955 Protein denotes CD25
T19113 31961-31964 Protein denotes CD4
T19114 31965-31969 Protein denotes CD44
T19115 31971-31975 Protein denotes CD25
T19116 32148-32151 Protein denotes CD4
T19117 32282-32287 Protein denotes CD11c
T19118 32346-32349 Protein denotes CD4
T19119 32544-32547 Protein denotes OVA
T19120 32555-32560 Protein denotes IL-12
T19121 32603-32606 Protein denotes CD4
T7860 13408-13413 Protein denotes IL-10
R62 T96 T97 themeOf Interleukin-10,Production
R63 T97 T98 themeOf Production,Requires
R64 T97 T99 themeOf Production,Requires
R65 T100 T101 causeOf Interleukin-12,Induced
R587 T101 T98 causeOf Induced,Requires
R588 T102 T101 themeOf STAT4,Induced
R589 T103 T104 themeOf ERK,Activation
R590 T104 T99 causeOf Activation,Requires
R591 T108 T106 themeOf interleukin-10,producing
R592 T109 T108 equivalentTo IL-10,interleukin-10
R593 T110 T107 themeOf interferon-γ,producing
R594 T111 T110 equivalentTo IFN-γ,interferon-γ
R595 T112 T113 themeOf IL-10,producing
R596 T114 T115 themeOf IL-10,producing
R597 T116 T119 themeOf ERK1,phosphorylation
R598 T117 T118 themeOf ERK2,phosphorylation
R599 T120 T121 causeOf IL-12,induced
R600 T122 T123 themeOf STAT4,activation
R601 T123 T121 themeOf activation,induced
R602 T125 T126 themeOf IL-10,production
R603 T126 T124 themeOf production,enhanced
R604 T129 T130 themeOf IL-10,producing
R605 T130 T128 themeOf producing,required
R606 T131 T136 causeOf activation,requirement
R607 T132 T135 causeOf activation,requirement
R608 T133 T132 themeOf ERK1,activation
R609 T134 T131 themeOf ERK2,activation
R610 T137 T135 themeOf production,requirement
R611 T137 T136 themeOf production,requirement
R612 T138 T137 themeOf IL-10,production
R613 T139 T140 themeOf IL-10,expression
R614 T141 T142 themeOf c-maf,expression
R615 T143 T144 themeOf IL-10,production
R742 T1024 T1023 themeOf interferon-γ,produce
R744 T1026 T1022 themeOf IL-10,produce
R745 T1030 T1029 themeOf IFN-γ,coproducing
R746 T1031 T1028 themeOf IL-10,coproducing
R747 T1032 T1033 themeOf IL-10,production
R758 T1050 T1049 themeOf IRAK,induced
R759 T1052 T1051 themeOf amounts,drive
R760 T1053 T1052 themeOf IFN-γ,amounts
R761 T1057 T1056 themeOf IL-4,expression
R762 T1057 T1066 themeOf IL-4,requires
R763 T1057 T1063 themeOf IL-4,requires
R764 T1057 T1061 themeOf IL-4,requires
R765 T1058 T1055 themeOf IL-5,expression
R766 T1058 T1062 themeOf IL-5,requires
R767 T1058 T1060 themeOf IL-5,requires
R768 T1058 T1064 themeOf IL-5,requires
R769 T1059 T1054 themeOf IL-13,expression
R770 T1059 T1068 themeOf IL-13,requires
R771 T1059 T1065 themeOf IL-13,requires
R772 T1059 T1067 themeOf IL-13,requires
R773 T1069 T1066 causeOf IL-4,requires
R774 T1069 T1062 causeOf IL-4,requires
R775 T1069 T1068 causeOf IL-4,requires
R776 T1070 T1063 causeOf STAT6,requires
R777 T1070 T1060 causeOf STAT6,requires
R778 T1070 T1065 causeOf STAT6,requires
R779 T1071 T1061 causeOf GATA binding protein (GATA)-3,requires
R780 T1071 T1064 causeOf GATA binding protein (GATA)-3,requires
R781 T1071 T1067 causeOf GATA binding protein (GATA)-3,requires
R782 T1074 T1075 causeOf STAT3,dependent
R783 T1076 T1075 themeOf expression,dependent
R784 T1077 T1076 themeOf RORγt,expression
R785 T1079 T1078 themeOf producing,result
R786 T1079 T1082 themeOf producing,independent
R787 T1080 T1079 themeOf IFN-γ,producing
R788 T1081 T1082 causeOf IL-12,independent
R789 T1083 T1086 themeOf ERK1,activation
R790 T1084 T1085 themeOf ERK2,activation
R791 T1085 T1088 causeOf activation,favor
R792 T1086 T1087 causeOf activation,favor
R793 T1089 T1090 themeOf IL-4,secretion
R794 T1090 T1087 themeOf secretion,favor
R795 T1090 T1088 themeOf secretion,favor
R796 T1091 T1092 themeOf IL-10,produced
R797 T1091 T1093 causeOf IL-10,act as a feedback regulator
R798 T1092 T1093 themeOf produced,act as a feedback regulator
R799 T1094 T1095 themeOf IL-10,production
R800 T1095 T1096 themeOf production,induced
R801 T1097 T1098 themeOf IL-10,producing
R802 T1102 T1105 themeOf ERK1,phosphorylation
R803 T1103 T1104 themeOf ERK2,phosphorylation
R804 T1106 T1111 causeOf activation,requirement
R805 T1107 T1110 causeOf activation,requirement
R806 T1108 T1107 themeOf ERK1,activation
R807 T1109 T1106 themeOf ERK2,activation
R808 T1112 T1110 themeOf production,requirement
R809 T1112 T1111 themeOf production,requirement
R810 T1113 T1112 themeOf IL-10,production
R811 T1114 T1115 themeOf IL-10,induction
R2157 T2897 T2895 themeOf production,inhibition
R2158 T2901 T2902 causeOf IL-12,induced
R2159 T2901 T2903 causeOf IL-12,induced
R2160 T2904 T2905 themeOf IFN-γ,expression
R2161 T2905 T2902 themeOf expression,induced
R2162 T2906 T2907 themeOf IL-10,expression
R2163 T2907 T2903 themeOf expression,induced
R2164 T2908 T2909 causeOf IL-12,induce
R2165 T2910 T2911 themeOf IL-10,production
R2166 T2911 T2909 themeOf production,induce
R2167 T2913 T2914 themeOf IL-10,producing
R2168 T2915 T2916 themeOf produced,more
R2169 T2917 T2915 themeOf IL-10,produced
R2170 T2918 T2920 themeOf producing,required
R2171 T2919 T2918 themeOf IL-10,producing
R2172 T2921 T2920 causeOf IL-12,required
R2173 T2924 T2922 themeOf IL-10,produce
R2174 T2925 T2923 themeOf IFN-γ,produce
R2175 T2927 T2926 themeOf produce,lost
R3686 T4887 T4888 themeOf IL-10,Production
R3687 T4888 T4889 themeOf Production,Dependent
R3688 T4894 T4896 themeOf producing,role
R3689 T4895 T4894 themeOf IL-10,producing
R3695 T4908 T4912 causeOf absence,diminished
R3696 T4908 T4913 causeOf absence,increase
R3697 T4908 T4914 causeOf absence,increase
R3698 T4909 T4908 themeOf STAT4,absence
R3699 T4910 T4912 themeOf expressing,diminished
R3700 T4911 T4910 themeOf IFN-γ,expressing
R3701 T4915 T4914 themeOf expressing,increase
R3702 T4916 T4913 themeOf expressing,increase
R3703 T4917 T4916 themeOf IL-4,expressing
R3704 T4918 T4915 themeOf IL-10,expressing
R3705 T4919 T4920 causeOf STAT4,contributes
R3706 T4921 T4922 themeOf IL-10,expression
R3707 T4922 T4920 themeOf expression,contributes
R3708 T4923 T4924 themeOf IL-10,expression
R3709 T4926 T4927 themeOf IL-10,producing
R3710 T4929 T4930 themeOf STAT6,activation
R3711 T4932 T4931 themeOf STAT6,absence
R3712 T4933 T4934 themeOf IL-10,producing
R3713 T4934 T4935 themeOf producing,in the presence of
R3714 T4934 T4936 themeOf producing,in the presence of
R3715 T4937 T4935 causeOf IL-12,in the presence of
R3716 T4938 T4936 causeOf OVA,in the presence of
R3717 T4939 T4940 themeOf STAT6,deficient
R3718 T4943 T4941 themeOf IL-10,produced
R3719 T4944 T4942 themeOf IFN-γ,produced
R3720 T4945 T4948 causeOf lack,abrogated
R3721 T4945 T4947 causeOf lack,abrogated
R3722 T4946 T4945 themeOf STAT6,lack
R3723 T4949 T4951 themeOf IL-4,production
R3724 T4950 T4952 themeOf IL-10,production
R3725 T4951 T4948 themeOf production,abrogated
R3726 T4952 T4947 themeOf production,abrogated
R3727 T4955 T4958 themeOf IL-10,production
R3728 T4956 T4957 themeOf IL-4,production
R3729 T4957 T4960 themeOf production,increased
R3730 T4958 T4959 themeOf production,increased
R3731 T4961 T4962 themeOf IL-10,expression
R3732 T4962 T4963 themeOf expression,depended
R3736 T4969 T4966 themeOf produce,inability
R3740 T4974 T4975 themeOf IFN-γ,deficient
R3741 T4979 T4981 themeOf secretion,induced
R3742 T4980 T4979 themeOf IL-10,secretion
R3743 T4982 T4983 themeOf IL-12,affected
R3744 T4984 T4983 causeOf absence,affected
R3745 T4985 T4984 themeOf IFN-γ,absence
R3746 T4986 T4988 themeOf expression,independent
R3747 T4987 T4986 themeOf IL-10,expression
R3748 T4989 T4988 causeOf IFN-γ,independent
R3749 T4990 T4992 causeOf absence,increase
R3750 T4991 T4990 themeOf IFN-γ,absence
R3751 T4993 T4992 themeOf secreted,increase
R3752 T4994 T4993 themeOf IL-4,secreted
R3753 T4996 T4995 causeOf IL-4,role
R3754 T4997 T4995 themeOf producing,role
R3755 T4998 T4997 themeOf IL-10,producing
R3756 T4999 T5000 themeOf IL-4,deficient
R3757 T5004 T5003 themeOf STAT6,absence
R3758 T5005 T5006 themeOf IL-4,deficiency
R3759 T5008 T5007 themeOf IL-10,producing
R3760 T5010 T5009 themeOf IL-10,producing
R3761 T5011 T5012 themeOf IL-10,production
R3762 T5013 T5015 causeOf STAT4,induction
R3763 T5016 T5017 themeOf IL-10,production
R3764 T5017 T5015 themeOf production,induction
R3765 T5017 T5014 themeOf production,induction
R3766 T5018 T5014 causeOf STAT6,induction
R5300 T6994 T6995 themeOf IL-10,Producing
R5977 T7878 T7877 themeOf production,resulted
R5978 T7879 T7878 themeOf IL-10,production
R5979 T7881 T7880 causeOf IL-12,need
R5980 T7882 T7883 themeOf IL-10,induction
R5981 T7883 T7880 themeOf induction,need
R5982 T7884 T7885 themeOf IL-10,induction
R5983 T7885 T7886 themeOf induction,abrogated
R5984 T7887 T7888 themeOf IL-12p40,deficient
R5985 T7888 T7886 causeOf deficient,abrogated
R5986 T7889 T7890 causeOf IL-12,essential
R5987 T7891 T7890 themeOf production,essential
R5988 T7892 T7891 themeOf IL-10,production
R5989 T7893 T7894 themeOf IL-10,producing
R5990 T7899 T7898 themeOf produce,induced
R5991 T7900 T7899 themeOf IL-10,produce
R5992 T7901 T7898 causeOf IL-12,induced
R5993 T7902 T7906 themeOf lost,compensated
R5994 T7903 T7902 themeOf express,lost
R5995 T7904 T7903 themeOf IL-10,express
R5996 T7905 T7902 causeOf OVA,lost
R5997 T7908 T7906 causeOf IL-12,compensated
R5998 T7908 T7907 themeOf IL-12,addition
R5999 T7911 T7910 themeOf induction,cooperate
R6000 T7912 T7911 themeOf IL-10,induction
R6001 T7917 T7915 themeOf IFN-γ,produced
R6002 T7918 T7916 themeOf IL-10,produced
R6003 T7920 T7919 themeOf produce,induced
R6004 T7921 T7920 themeOf IL-10,produce
R6005 T7922 T7919 causeOf IL-12,induced
R6006 T7923 T7924 causeOf IL-12,induction
R6007 T7925 T7926 themeOf IL-10,production
R6008 T7926 T7924 themeOf production,induction
R7085 T9277 T9279 themeOf ERK2,Activation
R7089 T9279 T9272 causeOf Activation,Requires
R7090 T9280 T9283 themeOf maintenance,required
R7091 T9281 T9282 themeOf IL-10,induction
R7092 T9282 T9280 themeOf induction,maintenance
R7093 T9285 T9284 themeOf IL-12,addition
R7094 T9288 T9290 themeOf ERK1,activation
R7095 T9289 T9291 themeOf ERK2,activation
R7096 T9290 T9287 themeOf activation,induced
R7097 T9290 T9292 themeOf activation,induced
R7098 T9291 T9286 themeOf activation,induced
R7099 T9291 T9293 themeOf activation,induced
R7100 T9296 T9299 themeOf ERK1,activation
R7101 T9297 T9298 themeOf ERK2,activation
R7102 T9304 T9307 themeOf ERK1,activation
R7103 T9305 T9306 themeOf ERK2,activation
R7104 T9306 T9300 themeOf activation,enhanced
R7105 T9306 T9302 themeOf activation,prolonged
R7106 T9307 T9301 themeOf activation,enhanced
R7107 T9307 T9303 themeOf activation,prolonged
R7108 T9308 T9301 causeOf IL-12,enhanced
R7109 T9308 T9300 causeOf IL-12,enhanced
R7110 T9309 T9312 themeOf ERK1,activation
R7111 T9310 T9311 themeOf ERK2,activation
R7112 T9311 T9314 causeOf activation,required
R7113 T9312 T9313 causeOf activation,required
R7114 T9315 T9313 themeOf induction,required
R7115 T9315 T9314 themeOf induction,required
R7116 T9316 T9315 themeOf IL-10,induction
R7117 T9322 T9321 themeOf IL-10,producing
R7118 T9323 T9320 themeOf IFN-γ,producing
R7119 T9325 T9324 themeOf production,abrogated
R7120 T9326 T9325 themeOf IL-10,production
R7121 T9333 T9334 causeOf MEK5,catalyzed
R7122 T9334 T9328 themeOf catalyzed,inhibits
R7123 T9335 T9334 themeOf activation,catalyzed
R7124 T9336 T9335 themeOf ERK5,activation
R7125 T9337 T9342 causeOf MEK1,catalyzed
R7126 T9337 T9340 causeOf MEK1,catalyzed
R7127 T9338 T9339 causeOf MEK2,catalyzed
R7128 T9338 T9341 causeOf MEK2,catalyzed
R7129 T9339 T9332 themeOf catalyzed,inhibits
R7130 T9340 T9331 themeOf catalyzed,inhibits
R7131 T9341 T9330 themeOf catalyzed,inhibits
R7132 T9342 T9329 themeOf catalyzed,inhibits
R7133 T9343 T9342 themeOf activation,catalyzed
R7134 T9343 T9339 themeOf activation,catalyzed
R7135 T9344 T9340 themeOf activation,catalyzed
R7136 T9344 T9341 themeOf activation,catalyzed
R7137 T9345 T9343 themeOf ERK1,activation
R7138 T9346 T9344 themeOf ERK2,activation
R7139 T9347 T9349 themeOf MEK1,inhibitor
R7140 T9348 T9350 themeOf MEK2,inhibitor
R7141 T9354 T9353 themeOf MEK1,inhibits
R7142 T9355 T9352 themeOf MEK2,inhibits
R7143 T9356 T9351 themeOf MEK5,inhibits
R7144 T9358 T9359 themeOf IL-10,production
R7145 T9359 T9357 themeOf production,inhibition
R7146 T9360 T9361 themeOf p38 MAPK,inhibitor
R7147 T9361 T9364 causeOf inhibitor,effect
R7148 T9362 T9363 themeOf GSK3β,inhibitor
R7149 T9363 T9365 causeOf inhibitor,effect
R7150 T9366 T9367 themeOf IL-10,production
R7151 T9367 T9364 themeOf production,effect
R7152 T9367 T9365 themeOf production,effect
R7153 T9368 T9369 themeOf IL-10,production
R7154 T9369 T9370 themeOf production,in response to
R7155 T9370 T9372 themeOf in response to,requires
R7156 T9370 T9373 themeOf in response to,requires
R7157 T9371 T9370 causeOf IL-12,in response to
R7158 T9376 T9275 themeOf activation,Requires
R7159 T9376 T9272 themeOf activation,Requires
R7160 T9376 T9372 causeOf activation,requires
R7161 T9377 T9273 themeOf activation,Requires
R7162 T9377 T9373 causeOf activation,requires
R7163 T9377 T9274 themeOf activation,Requires
R7164 T9378 T9376 themeOf p38,activation
R7165 T9379 T9377 themeOf GSK3β,activation
R8447 T10973 T10974 themeOf IL-10,Production
R8448 T10974 T10975 themeOf Production,Requires
R8449 T10974 T10976 themeOf Production,Requires
R8450 T10977 T10979 themeOf ERK1,Activation
R8451 T10978 T10980 themeOf ERK2,Activation
R8452 T10979 T10975 causeOf Activation,Requires
R8453 T10980 T10976 causeOf Activation,Requires
R8454 T10981 T10982 themeOf IL-10,production
R8455 T10982 T10983 themeOf production,dependent
R8456 T10982 T10984 themeOf production,dependent
R8457 T10985 T10987 themeOf ERK1,activation
R8458 T10986 T10988 themeOf ERK2,activation
R8459 T10987 T10984 causeOf activation,dependent
R8460 T10988 T10983 causeOf activation,dependent
R8461 T10991 T10992 themeOf MEK,inhibitor
R8462 T10993 T10996 themeOf ERK1,activation
R8463 T10994 T10995 themeOf ERK2,activation
R8464 T10995 T10997 causeOf activation,required
R8465 T10996 T10998 causeOf activation,required
R8466 T10999 T10998 themeOf induction,required
R8467 T10999 T10997 themeOf induction,required
R8468 T11000 T10999 themeOf IL-10,induction
R8469 T11001 T11002 themeOf IL-10,production
R8470 T11002 T11003 themeOf production,inhibited
R8471 T11004 T11005 themeOf MEK,inhibitor
R8472 T11005 T11003 causeOf inhibitor,inhibited
R8473 T11006 T11013 causeOf inhibitors,affect
R8474 T11007 T11012 causeOf inhibitors,affect
R8475 T11008 T11011 themeOf p38 MAPK,activation
R8476 T11009 T11010 themeOf GSK-3β,activation
R8477 T11010 T11006 themeOf activation,inhibitors
R8478 T11011 T11007 themeOf activation,inhibitors
R8479 T11014 T11012 themeOf expression,affect
R8480 T11014 T11013 themeOf expression,affect
R8481 T11015 T11014 themeOf IL-10,expression
R8482 T11019 T11018 themeOf induction,requirement
R8483 T11020 T11021 themeOf IL-10,production
R8484 T11021 T11019 themeOf production,induction
R9145 T11854 T11858 themeOf transcription,this effect
R9147 T11857 T11856 causeOf IL-12,induced
R9148 T11858 T11860 themeOf this effect,upregulated
R9149 T11859 T11858 causeOf IL-12,this effect
R9150 T11861 T11862 themeOf Il10,transcription
R9151 T11862 T11866 themeOf transcription,abrogated
R9152 T11863 T11864 themeOf Il4,expression
R9153 T11867 T11868 themeOf Il4,expression
R9154 T11868 T11865 themeOf expression,abrogated
R9155 T11869 T11870 causeOf IL-12,effect
R9156 T11871 T11870 themeOf increase,effect
R9157 T11872 T11873 themeOf IL-10,mRNA expression
R9158 T11873 T11871 themeOf mRNA expression,increase
R9159 T11874 T11875 causeOf IL-12,induced
R9160 T11874 T11876 causeOf IL-12,induced
R9161 T11877 T11878 themeOf Il10,transcription
R9162 T11878 T11875 themeOf transcription,induced
R9163 T11879 T11880 themeOf Ifnγ,expression
R9164 T11880 T11876 themeOf expression,induced
R9165 T11883 T11882 themeOf Tbx-21,express
R9166 T11884 T11883 equivalentTo T-bet,Tbx-21
R9167 T11886 T11887 themeOf GATA-3,mRNA expression
R9168 T11887 T11888 themeOf mRNA expression,downregulated
R9169 T11889 T11888 causeOf IL-12,downregulated
R9170 T11891 T11890 themeOf expression,led
R9171 T11891 T11893 themeOf expression,abrogated
R9172 T11892 T11891 themeOf c-maf,expression
R9173 T11894 T11895 causeOf IL-12,sustained
R9174 T11896 T11895 themeOf expression,sustained
R9175 T11897 T11896 themeOf c-Maf,expression
R9176 T11898 T11899 causeOf IL-12,maintenance
R9177 T11900 T11901 themeOf c-maf,expression
R9178 T11901 T11899 themeOf expression,maintenance
R9179 T11901 T11902 causeOf expression,required
R9180 T11903 T11904 themeOf STAT4,activation
R9181 T11904 T11902 themeOf activation,required
R9182 T11907 T11905 themeOf IL-17a,expressed
R9183 T11908 T11906 themeOf IL-10,expressed
R9184 T11909 T11912 themeOf T-bet,mRNA
R9185 T11910 T11911 themeOf GATA-3,mRNA
R9186 T11911 T11913 themeOf mRNA,undetectable
R9187 T11912 T11914 themeOf mRNA,undetectable
R9188 T11915 T11916 themeOf ROR-γt,high
R9189 T11918 T11917 themeOf c-maf,expressed
R9190 T11919 T11920 themeOf c-Maf,expressed
R9191 T11921 T11922 themeOf IL-10,expressing
R9192 T11923 T11924 themeOf Il10,expression
R9193 T11924 T11930 themeOf expression,inhibited
R9194 T11924 T11929 themeOf expression,inhibited
R9195 T11925 T11926 themeOf c-maf,expression
R9196 T11926 T11928 themeOf expression,inhibited
R9197 T11926 T11927 themeOf expression,inhibited
R9198 T11931 T11933 themeOf MEK1,inhibitor
R9199 T11932 T11934 themeOf MEK2,inhibitor
R9200 T11933 T11930 causeOf inhibitor,inhibited
R9201 T11933 T11928 causeOf inhibitor,inhibited
R9202 T11933 T11940 causeOf inhibitor,affected
R9203 T11933 T11941 causeOf inhibitor,affected
R9204 T11934 T11929 causeOf inhibitor,inhibited
R9205 T11934 T11927 causeOf inhibitor,inhibited
R9206 T11934 T11939 causeOf inhibitor,affected
R9207 T11934 T11942 causeOf inhibitor,affected
R9208 T11935 T11937 themeOf T-bet,expression
R9209 T11936 T11938 themeOf RORγt,expression
R9210 T11937 T11940 themeOf expression,affected
R9211 T11937 T11939 themeOf expression,affected
R9212 T11938 T11941 themeOf expression,affected
R9213 T11938 T11942 themeOf expression,affected
R10839 T13965 T13968 themeOf ERK1,phosphorylation
R10840 T13966 T13967 themeOf ERK2,phosphorylation
R10841 T13967 T13964 causeOf phosphorylation,required
R10843 T13969 T13970 causeOf IL-12,induced
R10844 T13971 T13972 themeOf STAT-4,activation
R10845 T13972 T13963 causeOf activation,required
R10846 T13972 T13970 themeOf activation,induced
R10848 T13973 T13964 themeOf produce,required
R10849 T13973 T13963 themeOf produce,required
R10850 T13974 T13973 themeOf IL-10,produce
R10851 T13975 T13977 themeOf ERK1,activation
R10852 T13976 T13978 themeOf ERK2,activation
R10853 T13977 T13980 causeOf activation,required
R10854 T13978 T13979 causeOf activation,required
R10855 T13981 T13980 themeOf production,required
R10856 T13981 T13979 themeOf production,required
R10857 T13981 T13984 themeOf production,provides a highly regulated feedback loop
R10858 T13982 T13981 themeOf IL-10,production
R10859 T13983 T13984 causeOf IL-10,provides a highly regulated feedback loop
R10860 T13987 T13986 themeOf express,induced
R10861 T13988 T13987 themeOf IL-10,express
R10862 T13989 T13990 themeOf IL-10,producing
R10863 T13996 T13994 themeOf IL-10,coproduce
R10864 T13997 T13995 themeOf IFN-γ,coproduce
R10865 T13999 T14000 themeOf IL-10,production
R10866 T14003 T14002 themeOf IL-10,producing
R10867 T14008 T14006 themeOf IFN-γ,expressing
R10868 T14009 T14007 themeOf IL-10,expressing
R10870 T14012 T14010 themeOf expression,lose
R10876 T14023 T14021 causeOf deficient,reduced
R10877 T14025 T14024 causeOf IL-12,requirement
R10878 T14026 T14024 themeOf induction,requirement
R10879 T14027 T14026 themeOf IL-10,induction
R10880 T14029 T14028 themeOf IL-10,producing
R10881 T14031 T14032 themeOf IL-10,production
R10882 T14032 T14033 themeOf production,induced
R10883 T14033 T14035 themeOf induced,independent
R10884 T14034 T14033 causeOf IL-12,induced
R10885 T14036 T14035 causeOf IFN-γ,independent
R10886 T14037 T14038 causeOf IFN-γ,mediating
R10887 T14039 T14040 themeOf IL-10,reactivation
R10888 T14040 T14038 themeOf reactivation,mediating
R10889 T14043 T14042 themeOf IL-10,express
R10890 T14044 T14048 themeOf induced,dependent
R10891 T14045 T14044 themeOf produce,induced
R10892 T14046 T14045 themeOf IL-10,produce
R10893 T14049 T14048 causeOf induction,dependent
R10894 T14050 T14049 themeOf IL-12,induction
R10895 T14051 T14052 causeOf IL-12,resulted
R10896 T14053 T14054 themeOf IL-10,production
R10897 T14054 T14052 themeOf production,resulted
R10898 T14055 T14058 themeOf ERK1,activation
R10899 T14056 T14057 themeOf ERK2,activation
R10900 T14059 T14062 causeOf increased,induce
R10901 T14060 T14059 themeOf expression,increased
R10902 T14061 T14060 themeOf IFN-γ,expression
R10903 T14063 T14062 themeOf increased,induce
R10904 T14064 T14065 themeOf IL-12,production
R10905 T14065 T14063 themeOf production,increased
R10906 T14067 T14068 themeOf IL-12,production
R10907 T14068 T14066 themeOf production,upregulate
R10908 T14070 T14069 causeOf IFN-γ,requirement
R10909 T14071 T14069 themeOf induce,requirement
R10910 T14072 T14071 themeOf IL-10,induce
R10911 T14073 T14075 causeOf upregulation,induced
R10912 T14074 T14073 themeOf IL-12,upregulation
R10913 T14076 T14075 themeOf IL-10,induced
R10914 T14077 T14078 themeOf IL-10,regulated
R10915 T14081 T14082 themeOf IL-10,production
R10916 T14082 T14080 themeOf production,negatively regulate
R10917 T14085 T14084 themeOf IL-10,induce
R10918 T14088 T14089 themeOf IL-4,production
R10919 T14089 T14087 themeOf production,regulates
R10920 T14090 T14093 themeOf ERK1,activation
R10921 T14090 T14095 causeOf ERK1,regulation
R10922 T14091 T14092 themeOf ERK2,activation
R10923 T14091 T14094 causeOf ERK2,regulation
R10924 T14096 T14097 themeOf IL-10,production
R10925 T14097 T14095 themeOf production,regulation
R10926 T14097 T14094 themeOf production,regulation
R10927 T14098 T14099 themeOf IL-10,produced
R10928 T14099 T14100 themeOf produced,regulated
R10938 T14114 T14115 themeOf IL-10,produced
R10939 T14114 T14116 themeOf IL-10,expression
R10940 T14118 T14117 themeOf T-bet,expression
R10941 T14119 T14120 themeOf IFN-γ,production
R10942 T14124 T14126 themeOf IL-10,expression
R10943 T14125 T14127 themeOf IFN-γ,expression
R10944 T14126 T14122 themeOf expression,required
R10945 T14127 T14123 themeOf expression,required
R10946 T14128 T14132 themeOf maintenance,conditional
R10947 T14128 T14131 themeOf maintenance,conditional
R10948 T14129 T14130 themeOf IL-10,expression
R10949 T14130 T14128 themeOf expression,maintenance
R10950 T14133 T14132 causeOf IL-12,conditional
R10951 T14134 T14131 causeOf IL-4,conditional
R10952 T14138 T14139 themeOf IL-10,produced
R10953 T14140 T14141 causeOf IL-12,downregulate
R10954 T14142 T14143 themeOf Gata-3,expression
R10955 T14143 T14141 themeOf expression,downregulate
R10956 T14145 T14146 themeOf IL-10,expression
R10957 T14146 T14144 themeOf expression,induce
R10958 T14147 T14149 themeOf Expression,diminished
R10959 T14147 T14150 themeOf Expression,maintained
R10960 T14148 T14147 themeOf c-maf,Expression
R10961 T14151 T14150 causeOf IL-12,maintained
R10962 T14152 T14153 themeOf c-maf,expression
R10963 T14152 T14161 themeOf c-maf,expression
R10964 T14153 T14158 themeOf expression,dependent
R10965 T14154 T14155 themeOf IL-10,producing
R10966 T14156 T14157 themeOf IL-10,dependent
R10967 T14159 T14160 themeOf ERK,activation
R10968 T14160 T14158 causeOf activation,dependent
R10969 T14160 T14157 causeOf activation,dependent
R10970 T14162 T14163 causeOf c-Maf,essential
R10971 T14164 T14165 themeOf IL-10,expression
R10972 T14165 T14163 themeOf expression,essential
R10973 T14168 T14167 themeOf make,induced
R10974 T14169 T14168 themeOf IL-10,make
R10975 T14170 T14173 themeOf ERK1,activation
R10976 T14170 T14175 causeOf ERK1,required
R10977 T14171 T14172 themeOf ERK2,activation
R10978 T14171 T14174 causeOf ERK2,required
R10979 T14176 T14177 themeOf IL-10,production
R10980 T14177 T14175 themeOf production,required
R10981 T14177 T14174 themeOf production,required
R10982 T14179 T14178 themeOf IL-10,expression
R10983 T14180 T14181 themeOf IL-10,expression
R10984 T14181 T14182 themeOf expression,induced
R10985 T14181 T14183 themeOf expression,amplified
R10986 T14181 T14184 themeOf expression,regulated
R10987 T14185 T14183 causeOf IL-12,amplified
R10988 T14185 T14184 causeOf IL-12,regulated
R10989 T14187 T14186 themeOf production,regulate
R10990 T14188 T14187 themeOf IL-10,production
R10991 T14190 T14191 themeOf IL-10,production
R10992 T14191 T14189 themeOf production,regulation
R14799 T18673 T18681 themeOf Rag1,deficient
R14800 T18674 T18679 themeOf IL-4,deficient
R14801 T18675 T18678 themeOf IFN-γ,deficient
R14802 T18676 T18682 themeOf STAT4,deficient
R14803 T18677 T18680 themeOf STAT6,deficient
R14804 T18684 T18683 equivalentTo OVA,ovalbumin
R14805 T18686 T18687 themeOf MEK,inhibitors
R14806 T18688 T18689 themeOf p38,inhibitor
R14807 T18690 T18691 themeOf GSK3β,inhibitor
R16012 T20235 T20236 themeOf STAT,deficient
R9138 T11844 T11845 themeOf IL-10,production
R9140 T11849 T11852 themeOf resulted,abrogated
R9141 T11850 T11849 themeOf transcription,resulted
R9142 T11851 T11850 themeOf Il4,transcription
R9143 T11853 T11852 causeOf IL-12,abrogated
R9146 T11855 T11854 themeOf Ifnγ,transcription
R9136 T11839 T11840 themeOf c-maf,Expression
R9137 T11841 T11842 themeOf IL-10,Production
R9139 T11845 T11843 themeOf production,regulating
R9144 T11854 T11856 themeOf transcription,induced
R2140 T2872 T2870 themeOf expressing,rise
R2141 T2873 T2871 themeOf expressing,rise
R2142 T2874 T2873 themeOf IFN-γ,expressing
R2143 T2875 T2872 themeOf IL-10,expressing
R2144 T2878 T2877 themeOf IL-4,expressed
R2145 T2879 T2876 themeOf IL-10,expressed
R2146 T2883 T2885 causeOf IL-12,resulted
R2147 T2883 T2884 causeOf IL-12,resulted
R2148 T2886 T2887 themeOf IFN-γ,producing
R2149 T2887 T2885 themeOf producing,resulted
R2150 T2888 T2884 themeOf coproduced,resulted
R2151 T2889 T2888 themeOf IL-10,coproduced
R2152 T2891 T2894 themeOf lack,resulted
R2153 T2892 T2891 themeOf IL-10,lack
R2154 T2892 T2893 themeOf IL-10,produced
R2155 T2895 T2894 causeOf inhibition,resulted
R2156 T2896 T2897 themeOf IL-10,production
R2136 T2862 T2861 themeOf IL-10,Producing
R2137 T2865 T2864 themeOf IFN-γ,coproducing
R2138 T2866 T2863 themeOf IL-10,coproducing
R2139 T2869 T2868 equivalentTo OVA,ovalbumin
R2176 T2928 T2927 themeOf IL-2,produce
R2177 T2931 T2932 themeOf IL-10,production
R2178 T2933 T2934 themeOf IL-10,producing
R2179 T2936 T2935 themeOf IL-2,limited
R2180 T2938 T2940 themeOf recombination-activating gene 1,deficient
R2181 T2939 T2938 equivalentTo Rag1,recombination-activating gene 1
R2182 T2941 T2942 causeOf IL-12,resulted
R2183 T2943 T2944 themeOf IL-10,expression
R2184 T2944 T2942 themeOf expression,resulted
R2185 T2944 T2945 themeOf expression,dependent
R2186 T2946 T2947 causeOf TGF-β,induce
R2187 T2948 T2947 themeOf IL-10,induce
R2188 T2950 T2952 causeOf neutralization,increased
R2189 T2951 T2950 themeOf TGF-β,neutralization
R2190 T2953 T2954 themeOf IL-10,production
R2191 T2954 T2952 themeOf production,increased
R2192 T2955 T2956 themeOf IL-10,producing
R2193 T2956 T2958 themeOf producing,depended
R2194 T2956 T2957 themeOf producing,depended
R2195 T2956 T2959 themeOf producing,depended
R2196 T2960 T2958 causeOf IL-12,depended
R2197 T2961 T2957 causeOf IL-2,depended
R2198 T2962 T2959 causeOf TGF-β,depended
R740 T1015 T1014 equivalentTo IL-10,erleukin-10
R741 T1017 T1018 themeOf IL-10,expressed
R743 T1025 T1024 equivalentTo IFN-γ,interferon-γ
R748 T1034 T1037 themeOf IL-10,produced
R749 T1035 T1036 themeOf IFN-γ,produced
R750 T1038 T1039 themeOf signal transducer and activator of transcription (STAT)1 ,activation
R751 T1039 T1041 themeOf activation,induced
R752 T1039 T1040 themeOf activation,induced
R753 T1039 T1051 causeOf activation,drive
R754 T1042 T1041 causeOf type I IFN,induced
R755 T1043 T1040 causeOf IFN-γ,induced
R756 T1045 T1044 equivalentTo T-bet,T-box 21
R757 T1048 T1049 causeOf IL-18,induced
R3690 T4897 T4896 causeOf STAT4,role
R3691 T4897 T4898 themeOf STAT4,activated
R3692 T4899 T4898 causeOf IL-12,activated
R3693 T4902 T4901 themeOf STAT4,deficient
R3694 T4905 T4906 themeOf IL-10,producing
R3733 T4966 T4971 themeOf inability,due
R3734 T4967 T4968 themeOf STAT4,deficient
R3735 T4968 T4966 causeOf deficient,inability
R3737 T4970 T4969 themeOf IL-10,produce
R3738 T4972 T4971 causeOf absence,due
R3739 T4973 T4972 themeOf IFN-γ,absence
R16339 T20626 T20628 themeOf ubiquitin,mRNA levels
R16340 T20627 T20629 themeOf HPRT,mRNA levels
R10842 T13968 T13962 causeOf phosphorylation,required
R10847 T13973 T13962 themeOf produce,required
R10929 T14103 T14105 themeOf ERK1,activation
R10930 T14104 T14106 themeOf ERK2,activation
R10931 T14105 T14102 causeOf activation,role
R10932 T14106 T14101 causeOf activation,role
R10933 T14107 T14102 themeOf induction,role
R10934 T14107 T14101 themeOf induction,role
R10935 T14108 T14109 themeOf IL-10,production
R10936 T14109 T14107 themeOf production,induction
R10937 T14111 T14110 themeOf IL-10,regulation
R10834 T13953 T13954 themeOf IL-10,expression
R10835 T13955 T13956 themeOf IL-10,expression
R10836 T13957 T13958 themeOf IL-10,produced
R10837 T13958 T13959 themeOf produced,in response to
R10838 T13961 T13960 themeOf IL-10,produce
R10869 T14011 T14012 themeOf IL-2,expression
R10871 T14014 T14013 themeOf IL-2,loss
R10872 T14016 T14015 themeOf IL-10,production
R10873 T14019 T14021 themeOf induction,reduced
R10874 T14020 T14019 themeOf IL-10,induction
R10875 T14022 T14023 themeOf STAT4,deficient
R7083 T9270 T9271 themeOf IL-10,Production
R7084 T9276 T9278 themeOf ERK1,Activation
R7086 T9278 T9274 causeOf Activation,Requires
R7087 T9278 T9275 causeOf Activation,Requires
R7088 T9279 T9273 causeOf Activation,Requires
R5301 T6997 T6998 themeOf IL-10,production
R5302 T6998 T6996 themeOf production,regulating
R5303 T7003 T7006 themeOf IL-10,production
R5304 T7004 T7005 themeOf IFN-γ,production
R5305 T7005 T7002 themeOf production,induced
R5306 T7006 T7001 themeOf production,induced
R5307 T7007 T7008 themeOf IL-10,production
R5308 T7008 T7009 themeOf production,enhanced
R5309 T7010 T7009 causeOf OVA,enhanced
R5310 T7013 T7014 themeOf IL-10,producing
R5311 T7015 T7017 themeOf STAT4,deficient
R5312 T7016 T7018 themeOf STAT6,deficient
R5313 T7020 T7024 themeOf expression,reduced
R5314 T7020 T7027 themeOf expression,completely abrogated
R5315 T7021 T7025 themeOf expression,reduced
R5316 T7021 T7026 themeOf expression,completely abrogated
R5317 T7022 T7021 themeOf IL-10,expression
R5318 T7023 T7020 themeOf IFN-γ,expression
R5319 T7031 T7032 themeOf IL-10,production
R5320 T7032 T7030 themeOf production,effect
R5321 T7033 T7034 themeOf STAT6,deficient
R15105 T19124 T19125 themeOf MEK,inhibitors
R15106 T19126 T19127 themeOf p38,inhibitor
R15107 T19128 T19129 themeOf GSK3β,inhibitor
R5969 T7860 T7861 themeOf IL-10,Production
R5970 T7861 T7862 themeOf Production,Maintained
R5971 T7863 T7862 causeOf IL-12,Maintained
R5972 T7867 T7866 themeOf IL-10,induction
R5973 T7870 T7871 causeOf IL-12,induce
R5974 T7872 T7873 themeOf IL-10,production
R5975 T7873 T7871 themeOf production,induce
R5976 T7874 T7875 themeOf IL-10,producing

2_test

Id Subject Object Predicate Lexical cue
19646904-11244051-46582664 1403-1407 11244051 denotes 2001
19646904-11244051-46582665 1561-1565 11244051 denotes 2004
19646904-15286781-46582665 1561-1565 15286781 denotes 2004
19646904-17041596-46582666 1680-1684 17041596 denotes 2001
19646904-17030951-46582666 1680-1684 17030951 denotes 2001
19646904-11244051-46582666 1680-1684 11244051 denotes 2001
19646904-11244051-46582667 1778-1782 11244051 denotes 2001
19646904-17283207-46582668 1944-1948 17283207 denotes 1998
19646904-7910138-46582668 1944-1948 7910138 denotes 1998
19646904-8419468-46582668 1944-1948 8419468 denotes 1998
19646904-8676077-46582668 1944-1948 8676077 denotes 1998
19646904-17283209-46582668 1944-1948 17283209 denotes 1998
19646904-9469440-46582668 1944-1948 9469440 denotes 1998
19646904-17525751-46582669 2005-2009 17525751 denotes 2007
19646904-17296790-46582669 2005-2009 17296790 denotes 2007
19646904-11244051-46582670 2111-2115 11244051 denotes 2006
19646904-15286781-46582670 2111-2115 15286781 denotes 2006
19646904-16903904-46582670 2111-2115 16903904 denotes 2006
19646904-17994022-46582671 2222-2226 17994022 denotes 2007
19646904-17994023-46582671 2222-2226 17994023 denotes 2007
19646904-17994024-46582671 2222-2226 17994024 denotes 2007
19646904-17994025-46582671 2222-2226 17994025 denotes 2007
19646904-17304625-46582672 2533-2537 17304625 denotes 1996
19646904-8676077-46582672 2533-2537 8676077 denotes 1996
19646904-8617936-46582672 2533-2537 8617936 denotes 1996
19646904-8609396-46582672 2533-2537 8609396 denotes 1996
19646904-8757617-46582672 2533-2537 8757617 denotes 1996
19646904-10479527-46582673 2713-2717 10479527 denotes 1999
19646904-11911827-46582674 2848-2852 11911827 denotes 2006
19646904-16751369-46582674 2848-2852 16751369 denotes 2006
19646904-17283207-46582675 2897-2901 17283207 denotes 2007
19646904-17283207-46582676 3027-3031 17283207 denotes 2007
19646904-17283209-46582676 3027-3031 17283209 denotes 2007
19646904-11244051-46582677 3221-3225 11244051 denotes 2007
19646904-17296790-46582677 3221-3225 17296790 denotes 2007
19646904-10898785-46582678 3454-3458 10898785 denotes 2007
19646904-18053739-46582678 3454-3458 18053739 denotes 2007
19646904-17433650-46582678 3454-3458 17433650 denotes 2007
19646904-10898785-46582679 3846-3850 10898785 denotes 2000
19646904-10898785-46582680 4020-4024 10898785 denotes 2000
19646904-18053739-46582681 4195-4199 18053739 denotes 2007
19646904-17433650-46582681 4195-4199 17433650 denotes 2007
19646904-7595230-46582682 4764-4768 7595230 denotes 2005
19646904-7595228-46582682 4764-4768 7595228 denotes 2005
19646904-12594266-46582682 4764-4768 12594266 denotes 2005
19646904-16172258-46582682 4764-4768 16172258 denotes 2005
19646904-10898785-46582683 4997-5001 10898785 denotes 2007
19646904-17433650-46582683 4997-5001 17433650 denotes 2007
19646904-7595230-46582684 6345-6349 7595230 denotes 1995
19646904-7595228-46582684 6345-6349 7595228 denotes 1995
19646904-14557415-46582685 8491-8495 14557415 denotes 2000
19646904-10880840-46582685 8491-8495 10880840 denotes 2000
19646904-10837066-46582686 9197-9201 10837066 denotes 2000
19646904-9846495-46582687 9266-9270 9846495 denotes 1998
19646904-10898785-46582688 10010-10014 10898785 denotes 2000
19646904-10837066-46582688 10010-10014 10837066 denotes 2000
19646904-16751369-46582689 10937-10941 16751369 denotes 2006
19646904-12594266-46582690 16053-16057 12594266 denotes 2003
19646904-17850214-46582691 17350-17354 17850214 denotes 2001
19646904-11478941-46582691 17350-17354 11478941 denotes 2001
19646904-17850214-46582692 17544-17548 17850214 denotes 2001
19646904-11478941-46582692 17544-17548 11478941 denotes 2001
19646904-17850214-46582693 17822-17826 17850214 denotes 2007
19646904-16517715-46582694 18410-18414 16517715 denotes 2006
19646904-19114668-46582694 18410-18414 19114668 denotes 2006
19646904-16473830-46582694 18410-18414 16473830 denotes 2006
19646904-8674125-46582695 20807-20811 8674125 denotes 1996
19646904-18053739-46582696 21288-21292 18053739 denotes 2007
19646904-19098919-46582697 21400-21404 19098919 denotes 2009
19646904-8674125-46582698 21601-21605 8674125 denotes 1996
19646904-17296790-46582699 22374-22378 17296790 denotes 2007
19646904-17283207-46582700 23002-23006 17283207 denotes 2006
19646904-17041596-46582700 23002-23006 17041596 denotes 2006
19646904-17030951-46582700 23002-23006 17030951 denotes 2006
19646904-10479527-46582701 23548-23552 10479527 denotes 1999
19646904-17283207-46582702 23787-23791 17283207 denotes 2007
19646904-17283209-46582703 23914-23918 17283209 denotes 2007
19646904-12466842-46582704 24292-24296 12466842 denotes 2006
19646904-16533885-46582704 24292-24296 16533885 denotes 2006
19646904-15032595-46582705 24597-24601 15032595 denotes 2004
19646904-11085755-46582706 24871-24875 11085755 denotes 2000
19646904-11911827-46582707 25181-25185 11911827 denotes 2002
19646904-11911827-46582708 25727-25731 11911827 denotes 2002
19646904-16751369-46582709 25880-25884 16751369 denotes 2006
19646904-16751369-46582710 26658-26662 16751369 denotes 2006
19646904-17304625-46582711 26924-26928 17304625 denotes 2005
19646904-15699140-46582711 26924-26928 15699140 denotes 2005
19646904-16275760-46582712 27136-27140 16275760 denotes 2005
19646904-17200410-46582713 27261-27265 17200410 denotes 2002
19646904-12207353-46582713 27261-27265 12207353 denotes 2002
19646904-15771580-46582714 27401-27405 15771580 denotes 2005
19646904-16670284-46582715 27977-27981 16670284 denotes 1999
19646904-10601019-46582715 27977-27981 10601019 denotes 1999
19646904-17304625-46582716 28107-28111 17304625 denotes 2005
19646904-15699140-46582716 28107-28111 15699140 denotes 2005
19646904-17304625-46582717 28243-28247 17304625 denotes 2007
19646904-17304625-46582718 28699-28703 17304625 denotes 2007
19646904-17304625-46582719 28847-28851 17304625 denotes 2006
19646904-16517715-46582719 28847-28851 16517715 denotes 2006
19646904-15749884-46582720 29499-29503 15749884 denotes 2005
19646904-2125367-46582721 30857-30861 2125367 denotes 2006
19646904-9846495-46582721 30857-30861 9846495 denotes 2006
19646904-16517715-46582721 30857-30861 16517715 denotes 2006
19646904-7595228-46582722 31426-31430 7595228 denotes 2006
19646904-16517715-46582722 31426-31430 16517715 denotes 2006
19646904-19114668-46582722 31426-31430 19114668 denotes 2006
19646904-16473830-46582722 31426-31430 16473830 denotes 2006
19646904-16517715-46582723 32071-32075 16517715 denotes 2009
19646904-19114668-46582723 32071-32075 19114668 denotes 2009
19646904-7595228-46582724 32257-32261 7595228 denotes 1995
19646904-7595228-46582725 32418-32422 7595228 denotes 1995
19646904-7595228-46582726 32825-32829 7595228 denotes 2006
19646904-16517715-46582726 32825-32829 16517715 denotes 2006
19646904-16473830-46582727 32909-32913 16473830 denotes 2006
19646904-7595228-46582728 33051-33055 7595228 denotes 2006
19646904-16517715-46582728 33051-33055 16517715 denotes 2006
19646904-16473830-46582728 33051-33055 16473830 denotes 2006
19646904-19114668-46582729 33134-33138 19114668 denotes 2009
19646904-16517715-46582730 33904-33908 16517715 denotes 2006
19646904-11085755-46582731 34070-34074 11085755 denotes 2000
19646904-16517715-46582732 35041-35045 16517715 denotes 2006
19646904-15485931-46582733 35560-35564 15485931 denotes 2004
T8805 1403-1407 11244051 denotes 2001
T65716 1561-1565 11244051 denotes 2004
T87249 1561-1565 15286781 denotes 2004
T52634 1680-1684 17041596 denotes 2001
T52687 1680-1684 17030951 denotes 2001
T23420 1680-1684 11244051 denotes 2001
T48009 1778-1782 11244051 denotes 2001
T34540 1944-1948 17283207 denotes 1998
T71986 1944-1948 7910138 denotes 1998
T78014 1944-1948 8419468 denotes 1998
T17579 1944-1948 8676077 denotes 1998
T81146 1944-1948 17283209 denotes 1998
T30548 1944-1948 9469440 denotes 1998
T26826 2005-2009 17525751 denotes 2007
T58519 2005-2009 17296790 denotes 2007
T81384 2111-2115 11244051 denotes 2006
T8730 2111-2115 15286781 denotes 2006
T97146 2111-2115 16903904 denotes 2006
T13686 2222-2226 17994022 denotes 2007
T94039 2222-2226 17994023 denotes 2007
T21079 2222-2226 17994024 denotes 2007
T4832 2222-2226 17994025 denotes 2007
T77435 2533-2537 17304625 denotes 1996
T59010 2533-2537 8676077 denotes 1996
T48224 2533-2537 8617936 denotes 1996
T87849 2533-2537 8609396 denotes 1996
T64123 2533-2537 8757617 denotes 1996
T8665 2713-2717 10479527 denotes 1999
T29385 2848-2852 11911827 denotes 2006
T57787 2848-2852 16751369 denotes 2006
T24022 2897-2901 17283207 denotes 2007
T2190 3027-3031 17283207 denotes 2007
T98080 3027-3031 17283209 denotes 2007
T63733 3221-3225 11244051 denotes 2007
T6560 3221-3225 17296790 denotes 2007
T37364 3454-3458 10898785 denotes 2007
T46015 3454-3458 18053739 denotes 2007
T48300 3454-3458 17433650 denotes 2007
T57018 3846-3850 10898785 denotes 2000
T82500 4020-4024 10898785 denotes 2000
T38820 4195-4199 18053739 denotes 2007
T90712 4195-4199 17433650 denotes 2007
T93907 4764-4768 7595230 denotes 2005
T87974 4764-4768 7595228 denotes 2005
T12507 4764-4768 12594266 denotes 2005
T81044 4764-4768 16172258 denotes 2005
T36969 4997-5001 10898785 denotes 2007
T64928 4997-5001 17433650 denotes 2007
T10777 6345-6349 7595230 denotes 1995
T18378 6345-6349 7595228 denotes 1995
T24066 8491-8495 14557415 denotes 2000
T49812 8491-8495 10880840 denotes 2000
T87692 9197-9201 10837066 denotes 2000
T54011 9266-9270 9846495 denotes 1998
T26062 10010-10014 10898785 denotes 2000
T38873 10010-10014 10837066 denotes 2000
T55638 10937-10941 16751369 denotes 2006
T89706 16053-16057 12594266 denotes 2003
T48317 17350-17354 17850214 denotes 2001
T94732 17350-17354 11478941 denotes 2001
T46911 17544-17548 17850214 denotes 2001
T53244 17544-17548 11478941 denotes 2001
T51427 17822-17826 17850214 denotes 2007
T40702 18410-18414 16517715 denotes 2006
T58715 18410-18414 19114668 denotes 2006
T81132 18410-18414 16473830 denotes 2006
T73147 20807-20811 8674125 denotes 1996
T82640 21288-21292 18053739 denotes 2007
T91884 21400-21404 19098919 denotes 2009
T85699 21601-21605 8674125 denotes 1996
T3209 22374-22378 17296790 denotes 2007
T91638 23002-23006 17283207 denotes 2006
T33515 23002-23006 17041596 denotes 2006
T20405 23002-23006 17030951 denotes 2006
T84879 23548-23552 10479527 denotes 1999
T90788 23787-23791 17283207 denotes 2007
T57941 23914-23918 17283209 denotes 2007
T90913 24292-24296 12466842 denotes 2006
T94758 24292-24296 16533885 denotes 2006
T4941 24597-24601 15032595 denotes 2004
T2613 24871-24875 11085755 denotes 2000
T65037 25181-25185 11911827 denotes 2002
T25294 25727-25731 11911827 denotes 2002
T75772 25880-25884 16751369 denotes 2006
T20765 26658-26662 16751369 denotes 2006
T99068 26924-26928 17304625 denotes 2005
T27807 26924-26928 15699140 denotes 2005
T50302 27136-27140 16275760 denotes 2005
T74942 27261-27265 17200410 denotes 2002
T1640 27261-27265 12207353 denotes 2002
T77280 27401-27405 15771580 denotes 2005
T28558 27977-27981 16670284 denotes 1999
T20759 27977-27981 10601019 denotes 1999
T94747 28107-28111 17304625 denotes 2005
T87182 28107-28111 15699140 denotes 2005
T61911 28243-28247 17304625 denotes 2007
T95963 28699-28703 17304625 denotes 2007
T20298 28847-28851 17304625 denotes 2006
T65739 28847-28851 16517715 denotes 2006
T20515 29499-29503 15749884 denotes 2005
T31648 30857-30861 2125367 denotes 2006
T44291 30857-30861 9846495 denotes 2006
T43212 30857-30861 16517715 denotes 2006
T65029 31426-31430 7595228 denotes 2006
T80322 31426-31430 16517715 denotes 2006
T12248 31426-31430 19114668 denotes 2006
T50653 31426-31430 16473830 denotes 2006
T12886 32071-32075 16517715 denotes 2009
T76331 32071-32075 19114668 denotes 2009
T56198 32257-32261 7595228 denotes 1995
T90247 32418-32422 7595228 denotes 1995
T23895 32825-32829 7595228 denotes 2006
T17847 32825-32829 16517715 denotes 2006
T7800 32909-32913 16473830 denotes 2006
T26722 33051-33055 7595228 denotes 2006
T21930 33051-33055 16517715 denotes 2006
T91220 33051-33055 16473830 denotes 2006
T52976 33134-33138 19114668 denotes 2009
T17082 33904-33908 16517715 denotes 2006
T80560 34070-34074 11085755 denotes 2000
T94515 35041-35045 16517715 denotes 2006
T47248 35560-35564 15485931 denotes 2004

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T154 0-14 NN denotes Interleukin-10
T155 15-25 NN denotes Production
T156 26-28 IN denotes by
T157 29-32 NN denotes Th1
T158 33-38 NN denotes Cells
T159 39-47 VB denotes Requires
T160 48-70 JJ denotes Interleukin-12-Induced
T161 71-76 NN denotes STAT4
T162 77-90 NN denotes Transcription
T163 91-97 NN denotes Factor
T164 98-101 CC denotes and
T165 102-105 NN denotes ERK
T166 106-109 NN denotes MAP
T167 110-116 NN denotes Kinase
T168 117-127 NN denotes Activation
T169 128-130 IN denotes by
T170 131-135 JJ denotes High
T171 136-143 NN denotes Antigen
T172 144-148 NN denotes Dose
T173 160-167 NNP denotes Summary
T174 168-172 JJ denotes CD4+
T175 173-180 NN denotes T cells
T176 181-190 VB denotes producing
T177 191-205 NN denotes interleukin-10
T178 206-207 -LRB- denotes (
T179 207-212 NN denotes IL-10
T180 212-213 -RRB- denotes )
T181 214-217 CC denotes and
T182 218-230 NN denotes interferon-γ
T183 231-232 -LRB- denotes (
T184 232-237 NN denotes IFN-γ
T185 237-238 -RRB- denotes )
T186 239-242 VB denotes are
T187 243-251 VB denotes reported
T188 252-254 IN denotes in
T189 255-262 JJ denotes chronic
T190 263-273 NN denotes infections
T191 275-282 RB denotes However
T192 282-283 -COMMA- denotes ,
T193 284-287 DT denotes the
T194 288-295 NN denotes signals
T195 296-300 WDT denotes that
T196 301-307 VB denotes direct
T197 308-311 DT denotes the
T198 312-323 NN denotes development
T199 324-326 IN denotes of
T200 327-342 JJ denotes IL-10-producing
T201 343-344 NN denotes T
T202 345-351 NN denotes helper
T203 352-353 CD denotes 1
T204 354-355 -LRB- denotes (
T205 355-358 NN denotes Th1
T206 358-359 -RRB- denotes )
T207 360-365 NN denotes cells
T208 366-369 VB denotes are
T209 370-379 JJ denotes undefined
T210 381-383 PRP denotes We
T211 384-390 VB denotes showed
T212 391-395 IN denotes that
T213 396-407 NN denotes development
T214 408-410 IN denotes of
T215 411-426 JJ denotes IL-10-producing
T216 427-430 NN denotes Th1
T217 431-436 NN denotes cells
T218 437-445 VB denotes required
T219 446-450 JJ denotes high
T220 451-457 NN denotes T cell
T221 458-466 NN denotes receptor
T222 467-468 -LRB- denotes (
T223 468-471 NN denotes TCR
T224 471-472 -RRB- denotes )
T225 473-481 NN denotes ligation
T226 481-482 -COMMA- denotes ,
T227 483-492 JJ denotes sustained
T228 493-497 NN denotes ERK1
T229 498-501 CC denotes and
T230 502-506 NN denotes ERK2
T231 507-510 NN denotes MAP
T232 511-518 NN denotes kinases
T233 519-534 NN denotes phosphorylation
T234 534-535 -COMMA- denotes ,
T235 536-539 CC denotes and
T236 540-553 JJ denotes IL-12-induced
T237 554-559 NN denotes STAT4
T238 560-573 NN denotes transcription
T239 574-580 NN denotes factor
T240 581-591 NN denotes activation
T241 593-601 VB denotes Repeated
T242 602-605 NN denotes TCR
T243 606-616 NN denotes triggering
T244 617-620 VB denotes led
T245 621-623 TO denotes to
T246 624-632 VB denotes enhanced
T247 633-638 NN denotes IL-10
T248 639-649 NN denotes production
T249 650-652 IN denotes by
T250 653-656 NN denotes Th1
T251 657-662 NN denotes cells
T252 662-663 -COMMA- denotes ,
T253 664-667 CC denotes and
T254 668-677 JJ denotes continued
T255 678-683 NN denotes IL-12
T256 684-690 NN denotes action
T257 691-694 CC denotes and
T258 695-704 JJ denotes high-dose
T259 705-708 NN denotes TCR
T260 709-718 NN denotes signaling
T261 719-723 VB denotes were
T262 724-732 VB denotes required
T263 733-736 IN denotes for
T264 737-740 DT denotes the
T265 741-752 NN denotes development
T266 753-756 CC denotes and
T267 757-768 NN denotes maintenance
T268 769-771 IN denotes of
T269 772-787 JJ denotes IL-10-producing
T270 788-791 NN denotes Th1
T271 792-797 NN denotes cells
T272 799-807 IN denotes Although
T273 808-811 NN denotes Th1
T274 811-812 -COMMA- denotes ,
T275 813-816 NN denotes Th2
T276 816-817 -COMMA- denotes ,
T277 818-821 CC denotes and
T278 822-826 NN denotes Th17
T279 827-832 NN denotes cells
T280 833-840 VB denotes require
T281 841-844 DT denotes the
T282 845-855 NN denotes activation
T283 856-858 IN denotes of
T284 859-867 JJ denotes distinct
T285 868-873 NN denotes STATs
T286 874-877 IN denotes for
T287 878-883 PRP-DOLLAR- denotes their
T288 884-899 NN denotes differentiation
T289 899-900 -COMMA- denotes ,
T290 901-911 NN denotes activation
T291 912-914 IN denotes of
T292 915-919 NN denotes ERK1
T293 920-923 CC denotes and
T294 924-928 NN denotes ERK2
T295 929-934 NN denotes was a
T296 935-941 JJ denotes common
T297 942-953 NN denotes requirement
T298 954-957 IN denotes for
T299 958-968 NN denotes production
T300 969-971 IN denotes of
T301 972-977 NN denotes IL-10
T302 978-980 IN denotes by
T303 981-984 DT denotes all
T304 985-987 NN denotes Th
T305 988-992 NN denotes cell
T306 993-1000 NN denotes subsets
T307 1002-1007 NN denotes IL-10
T308 1008-1018 NN denotes expression
T309 1019-1023 RB denotes also
T310 1024-1034 VB denotes correlated
T311 1035-1039 IN denotes with
T312 1040-1045 NN denotes c-maf
T313 1046-1056 NN denotes expression
T314 1058-1065 IN denotes Despite
T315 1066-1072 VB denotes having
T316 1073-1081 JJ denotes distinct
T317 1082-1091 NN denotes functions
T318 1092-1094 IN denotes in
T319 1095-1105 NN denotes protection
T320 1106-1113 IN denotes against
T321 1114-1123 NN denotes pathogens
T322 1123-1124 -COMMA- denotes ,
T323 1125-1128 DT denotes all
T324 1129-1131 NN denotes Th
T325 1132-1137 NN denotes cells
T326 1138-1143 VB denotes share
T327 1144-1147 DT denotes the
T328 1148-1157 JJ denotes important
T329 1158-1162 NN denotes task
T330 1163-1165 IN denotes of
T331 1166-1177 VB denotes controlling
T332 1178-1191 JJ denotes overexuberant
T333 1192-1198 JJ denotes immune
T334 1199-1208 NN denotes responses
T335 1209-1211 IN denotes by
T336 1212-1217 NN denotes means
T337 1218-1220 IN denotes of
T338 1221-1226 NN denotes IL-10
T339 1227-1237 NN denotes production
T2978 5900-5905 NN denotes IL-12
T2979 5906-5909 CC denotes and
T2980 5910-5914 JJ denotes High
T2981 5915-5920 NN denotes Doses
T2982 5921-5923 IN denotes of
T2983 5924-5931 NN denotes Antigen
T2984 5932-5938 VB denotes Induce
T2985 5939-5942 DT denotes the
T2986 5943-5954 NN denotes Development
T2987 5955-5957 IN denotes of
T2988 5958-5961 NN denotes Th1
T2989 5962-5967 NN denotes Cells
T2990 5968-5977 VB denotes Producing
T2991 5978-5983 NN denotes IL-10
T2992 5984-5986 TO denotes To
T2993 5987-5992 VB denotes study
T2994 5993-5996 DT denotes the
T2995 5997-6012 NN denotes differentiation
T2996 6013-6015 IN denotes of
T2997 6016-6019 NN denotes Th1
T2998 6020-6025 NN denotes cells
T2999 6026-6037 VB denotes coproducing
T3000 6038-6043 NN denotes IFN-γ
T3001 6044-6047 CC denotes and
T3002 6048-6053 NN denotes IL-10
T3003 6053-6054 -COMMA- denotes ,
T3004 6055-6057 PRP denotes we
T3005 6058-6066 VB denotes cultured
T3006 6067-6075 VB denotes purified
T3007 6076-6090 JJ denotes TCR-transgenic
T3008 6091-6098 NN denotes DO11.10
T3009 6099-6104 JJ denotes naive
T3010 6105-6109 JJ denotes CD4+
T3011 6110-6117 NN denotes T cells
T3012 6118-6122 IN denotes with
T3013 6123-6131 VB denotes purified
T3014 6132-6135 NN denotes DCs
T3015 6136-6138 IN denotes as
T3016 6139-6143 NN denotes APCs
T3017 6144-6147 CC denotes and
T3018 6148-6158 VB denotes increasing
T3019 6159-6164 NN denotes doses
T3020 6165-6167 IN denotes of
T3021 6168-6177 NN denotes ovalbumin
T3022 6178-6185 NN denotes peptide
T3023 6186-6193 CD denotes 323-339
T3024 6194-6195 -LRB- denotes (
T3025 6195-6198 NN denotes OVA
T3026 6198-6199 -RRB- denotes )
T3027 6201-6208 NN denotes Culture
T3028 6209-6213 IN denotes with
T3029 6214-6218 JJ denotes high
T3030 6219-6224 NN denotes doses
T3031 6225-6227 IN denotes of
T3032 6228-6235 NN denotes antigen
T3033 6236-6239 IN denotes for
T3034 6240-6241 CD denotes 7
T3035 6242-6246 NN denotes days
T3036 6247-6251 VB denotes gave
T3037 6252-6256 NN denotes rise
T3038 6257-6259 TO denotes to
T3039 6260-6263 NN denotes Th1
T3040 6264-6269 NN denotes cells
T3041 6270-6280 VB denotes expressing
T3042 6281-6286 NN denotes IFN-γ
T3043 6287-6291 IN denotes upon
T3044 6292-6305 NN denotes restimulation
T3045 6306-6307 -LRB- denotes (
T3046 6307-6315 JJ denotes Constant
T3047 6316-6322 NN denotes et al.
T3048 6322-6323 -COMMA- denotes ,
T3049 6324-6328 CD denotes 1995
T3050 6328-6329 -COLON- denotes ;
T3051 6330-6336 NNP denotes Hosken
T3052 6337-6343 FW denotes et al.
T3053 6343-6344 -COMMA- denotes ,
T3054 6345-6349 CD denotes 1995
T3055 6349-6350 -RRB- denotes )
T3056 6350-6351 -COMMA- denotes ,
T3057 6352-6355 CC denotes but
T3058 6356-6359 RB denotes not
T3059 6360-6365 NN denotes IL-10
T3060 6366-6367 -LRB- denotes (
T3061 6367-6377 NN denotes Figure S1A
T3062 6378-6387 JJ denotes available
T3063 6388-6394 NN denotes online
T3064 6394-6395 -RRB- denotes )
T3065 6397-6404 NN denotes Culture
T3066 6405-6409 IN denotes with
T3067 6410-6413 JJ denotes low
T3068 6414-6421 NN denotes antigen
T3069 6422-6427 NN denotes doses
T3070 6428-6433 IN denotes under
T3071 6434-6437 DT denotes the
T3072 6438-6442 JJ denotes same
T3073 6443-6453 NN denotes conditions
T3074 6454-6457 VB denotes led
T3075 6458-6460 TO denotes to
T3076 6461-6464 DT denotes the
T3077 6465-6480 NN denotes differentiation
T3078 6481-6483 IN denotes of
T3079 6484-6487 NN denotes Th2
T3080 6488-6493 NN denotes cells
T3081 6493-6494 -COMMA- denotes ,
T3082 6495-6500 WDT denotes which
T3083 6501-6510 VB denotes expressed
T3084 6511-6515 CC denotes both
T3085 6516-6520 NN denotes IL-4
T3086 6521-6524 CC denotes and
T3087 6525-6530 NN denotes IL-10
T3088 6531-6535 IN denotes upon
T3089 6536-6549 NN denotes restimulation
T3090 6550-6551 -LRB- denotes (
T3091 6551-6561 NN denotes Figure S1A
T3092 6561-6562 -RRB- denotes )
T3093 6564-6571 NN denotes Culture
T3094 6572-6574 IN denotes of
T3095 6575-6580 JJ denotes naive
T3096 6581-6585 JJ denotes CD4+
T3097 6586-6593 NN denotes T cells
T3098 6594-6596 IN denotes in
T3099 6597-6599 DT denotes an
T3100 6600-6608 JJ denotes APC-free
T3101 6609-6615 NN denotes system
T3102 6616-6618 IN denotes by
T3103 6619-6630 NN denotes stimulation
T3104 6631-6635 IN denotes with
T3105 6636-6644 JJ denotes anti-CD3
T3106 6645-6648 CC denotes and
T3107 6649-6658 JJ denotes anti-CD28
T3108 6659-6669 NN denotes antibodies
T3109 6670-6672 IN denotes in
T3110 6673-6676 DT denotes the
T3111 6677-6685 NN denotes presence
T3112 6686-6688 IN denotes of
T3113 6689-6694 NN denotes IL-12
T3114 6695-6703 VB denotes resulted
T3115 6704-6706 IN denotes in
T3116 6707-6722 JJ denotes IFN-γ-producing
T3117 6723-6726 NN denotes Th1
T3118 6727-6732 NN denotes cells
T3119 6732-6733 -COMMA- denotes ,
T3120 6734-6735 DT denotes a
T3121 6736-6746 NN denotes proportion
T3122 6747-6749 IN denotes of
T3123 6750-6755 WDT denotes which
T3124 6756-6766 VB denotes coproduced
T3125 6767-6772 NN denotes IL-10
T3126 6772-6773 -COMMA- denotes ,
T3127 6774-6776 IN denotes as
T3128 6777-6780 VB denotes did
T3129 6781-6784 NN denotes Th2
T3130 6785-6790 NN denotes cells
T3131 6791-6800 VB denotes resulting
T3132 6801-6805 IN denotes from
T3133 6806-6813 NN denotes culture
T3134 6814-6816 IN denotes in
T3135 6817-6821 NN denotes IL-4
T3136 6822-6823 -LRB- denotes (
T3137 6823-6833 NN denotes Figure S1B
T3138 6833-6834 -RRB- denotes )
T3139 6836-6838 TO denotes To
T3140 6839-6850 VB denotes investigate
T3141 6851-6858 IN denotes whether
T3142 6859-6862 DT denotes the
T3143 6863-6867 NN denotes lack
T3144 6868-6870 IN denotes of
T3145 6871-6876 NN denotes IL-10
T3146 6877-6885 VB denotes produced
T3147 6886-6888 IN denotes by
T3148 6889-6892 NN denotes Th1
T3149 6893-6898 NN denotes cells
T3150 6899-6907 VB denotes resulted
T3151 6908-6912 IN denotes from
T3152 6913-6923 NN denotes inhibition
T3153 6924-6926 IN denotes of
T3154 6927-6932 NN denotes IL-10
T3155 6933-6943 NN denotes production
T3156 6944-6946 IN denotes by
T3157 6947-6950 NN denotes DCs
T3158 6951-6954 CC denotes and
T3159 6955-6959 JJ denotes high
T3160 6960-6967 NN denotes antigen
T3161 6968-6972 NN denotes dose
T3162 6973-6975 CC denotes or
T3163 6976-6989 RB denotes alternatively
T3164 6990-6998 VB denotes required
T3165 6999-7004 NN denotes IL-12
T3166 7004-7005 -COMMA- denotes ,
T3167 7006-7008 PRP denotes we
T3168 7009-7017 VB denotes cultured
T3169 7018-7023 JJ denotes naive
T3170 7024-7028 JJ denotes CD4+
T3171 7029-7036 NN denotes T cells
T3172 7037-7041 IN denotes with
T3173 7042-7052 VB denotes increasing
T3174 7053-7058 NN denotes doses
T3175 7059-7061 IN denotes of
T3176 7062-7069 NN denotes antigen
T3177 7070-7079 VB denotes presented
T3178 7080-7082 IN denotes by
T3179 7083-7085 NN denotes DC
T3180 7086-7088 IN denotes in
T3181 7089-7092 DT denotes the
T3182 7093-7101 NN denotes presence
T3183 7102-7104 IN denotes of
T3184 7105-7110 NN denotes IL-12
T3185 7112-7114 IN denotes At
T3186 7115-7118 JJ denotes low
T3187 7119-7124 NN denotes doses
T3188 7125-7127 IN denotes of
T3189 7128-7135 NN denotes antigen
T3190 7135-7136 -COMMA- denotes ,
T3191 7137-7142 NN denotes IL-12
T3192 7143-7152 VB denotes abrogated
T3193 7153-7156 DT denotes the
T3194 7157-7168 NN denotes development
T3195 7169-7171 IN denotes of
T3196 7172-7175 NN denotes Th2
T3197 7176-7181 NN denotes cells
T3198 7182-7185 CC denotes and
T3199 7186-7193 VB denotes induced
T3200 7194-7199 NN denotes IFN-γ
T3201 7200-7210 NN denotes expression
T3202 7211-7214 CC denotes but
T3203 7215-7219 RB denotes only
T3204 7220-7223 JJ denotes low
T3205 7224-7230 NN denotes levels
T3206 7231-7233 IN denotes of
T3207 7234-7239 NN denotes IL-10
T3208 7240-7250 NN denotes expression
T3209 7250-7251 -COMMA- denotes ,
T3210 7252-7262 VB denotes suggesting
T3211 7263-7267 IN denotes that
T3212 7268-7273 NN denotes IL-12
T3213 7274-7277 FW denotes per
T3214 7278-7280 FW denotes se
T3215 7281-7284 VB denotes was
T3216 7285-7288 RB denotes not
T3217 7289-7299 JJ denotes sufficient
T3218 7300-7302 TO denotes to
T3219 7303-7309 VB denotes induce
T3220 7310-7321 JJ denotes significant
T3221 7322-7327 NN denotes IL-10
T3222 7328-7338 NN denotes production
T3223 7339-7341 IN denotes in
T3224 7342-7345 NN denotes Th1
T3225 7346-7351 NN denotes cells
T3226 7352-7353 -LRB- denotes (
T3227 7353-7362 NN denotes Figure 1A
T3228 7362-7363 -RRB- denotes )
T3229 7365-7375 RB denotes Strikingly
T3230 7375-7376 -COMMA- denotes ,
T3231 7377-7379 IN denotes as
T3232 7380-7383 DT denotes the
T3233 7384-7391 NN denotes antigen
T3234 7392-7396 NN denotes dose
T3235 7397-7400 VB denotes was
T3236 7401-7410 VB denotes increased
T3237 7410-7411 -COMMA- denotes ,
T3238 7412-7415 NN denotes Th1
T3239 7416-7427 NN denotes populations
T3240 7428-7434 VB denotes driven
T3241 7435-7439 IN denotes with
T3242 7440-7445 NN denotes IL-12
T3243 7446-7449 RB denotes now
T3244 7450-7459 VB denotes contained
T3245 7460-7466 JJ denotes higher
T3246 7467-7474 NN denotes numbers
T3247 7475-7477 IN denotes of
T3248 7478-7493 JJ denotes IL-10-producing
T3249 7494-7499 NN denotes cells
T3250 7500-7501 -LRB- denotes (
T3251 7501-7510 NN denotes Figure 1A
T3252 7510-7511 -RRB- denotes )
T3253 7512-7515 CC denotes and
T3254 7516-7524 VB denotes produced
T3255 7525-7529 JJ denotes more
T3256 7530-7535 NN denotes IL-10
T3257 7536-7543 NN denotes protein
T3258 7544-7548 IN denotes upon
T3259 7549-7562 NN denotes restimulation
T3260 7563-7564 -LRB- denotes (
T3261 7564-7571 NN denotes Figures
T3262 7572-7574 NN denotes 1A
T3263 7575-7578 CC denotes and
T3264 7579-7581 NN denotes 1B
T3265 7581-7582 -RRB- denotes )
T3266 7584-7588 RB denotes Thus
T3267 7588-7589 -COMMA- denotes ,
T3268 7590-7593 DT denotes the
T3269 7594-7605 NN denotes development
T3270 7606-7608 IN denotes of
T3271 7609-7612 NN denotes Th1
T3272 7613-7618 NN denotes cells
T3273 7619-7628 VB denotes producing
T3274 7629-7634 NN denotes IL-10
T3275 7635-7643 VB denotes required
T3276 7644-7648 CC denotes both
T3277 7649-7654 NN denotes IL-12
T3278 7655-7658 CC denotes and
T3279 7659-7663 JJ denotes high
T3280 7664-7669 NN denotes doses
T3281 7670-7672 IN denotes of
T3282 7673-7680 NN denotes antigen
T3283 7682-7685 NN denotes Th1
T3284 7686-7691 NN denotes cells
T3285 7692-7706 VB denotes differentiated
T3286 7707-7709 TO denotes to
T3287 7710-7717 VB denotes produce
T3288 7718-7723 JJ denotes large
T3289 7724-7731 NN denotes amounts
T3290 7732-7734 IN denotes of
T3291 7735-7740 NN denotes IL-10
T3292 7741-7744 CC denotes and
T3293 7745-7750 NN denotes IFN-γ
T3294 7751-7754 CC denotes and
T3295 7755-7759 VB denotes lost
T3296 7760-7774 NN denotes their capacity
T3297 7775-7777 TO denotes to
T3298 7778-7785 VB denotes produce
T3299 7786-7790 NN denotes IL-2
T3300 7791-7792 -LRB- denotes (
T3301 7792-7801 NN denotes Figure 1B
T3302 7801-7802 -RRB- denotes )
T3303 7804-7811 IN denotes Because
T3304 7812-7815 DT denotes the
T3305 7816-7824 NN denotes presence
T3306 7825-7827 IN denotes of
T3307 7828-7833 NN denotes IL-12
T3308 7834-7841 VB denotes reduced
T3309 7842-7845 DT denotes the
T3310 7846-7859 NN denotes proliferation
T3311 7860-7862 IN denotes of
T3312 7863-7867 JJ denotes CD4+
T3313 7868-7875 NN denotes T cells
T3314 7876-7878 IN denotes at
T3315 7879-7883 CC denotes both
T3316 7884-7888 JJ denotes high
T3317 7889-7896 NN denotes and low
T3318 7897-7904 NN denotes antigen
T3319 7905-7910 NN denotes doses
T3320 7911-7912 -LRB- denotes (
T3321 7912-7917 JJ denotes Table
T3322 7918-7920 NN denotes S1
T3323 7920-7921 -RRB- denotes )
T3324 7921-7922 -COMMA- denotes ,
T3325 7923-7926 CC denotes and
T3326 7927-7931 RB denotes only
T3327 7932-7935 DT denotes the
T3328 7936-7942 JJ denotes former
T3329 7943-7949 VB denotes showed
T3330 7950-7955 NN denotes IL-10
T3331 7956-7966 NN denotes production
T3332 7966-7967 -COMMA- denotes ,
T3333 7968-7971 DT denotes the
T3334 7972-7983 NN denotes development
T3335 7984-7986 IN denotes of
T3336 7987-7991 JJ denotes high
T3337 7992-8007 JJ denotes IL-10-producing
T3338 8008-8016 NN denotes cells is
T3339 8017-8021 RB denotes most
T3340 8022-8028 RB denotes likely
T3341 8029-8032 RB denotes not
T3342 8033-8040 JJ denotes related
T3343 8041-8043 TO denotes to
T3344 8044-8051 JJ denotes limited
T3345 8052-8056 NN denotes IL-2
T3346 8058-8063 JJ denotes Naive
T3347 8064-8068 JJ denotes CD4+
T3348 8069-8076 NN denotes T cells
T3349 8077-8081 IN denotes from
T3350 8082-8114 JJ denotes DO11.10/recombination-activating
T3351 8115-8119 NN denotes gene
T3352 8120-8121 CD denotes 1
T3353 8122-8123 -LRB- denotes (
T3354 8123-8127 NN denotes Rag1
T3355 8127-8128 -RRB- denotes )
T3356 8128-8138 JJ denotes -deficient
T3357 8139-8146 NN denotes animals
T3358 8146-8147 -COMMA- denotes ,
T3359 8148-8156 VB denotes cultured
T3360 8157-8161 IN denotes with
T3361 8162-8166 JJ denotes high
T3362 8167-8172 NN denotes doses
T3363 8173-8175 IN denotes of
T3364 8176-8183 NN denotes antigen
T3365 8184-8186 IN denotes in
T3366 8187-8190 DT denotes the
T3367 8191-8199 NN denotes presence
T3368 8200-8202 IN denotes of
T3369 8203-8208 NN denotes IL-12
T3370 8208-8209 -COMMA- denotes ,
T3371 8210-8214 RB denotes also
T3372 8215-8223 VB denotes resulted
T3373 8224-8226 IN denotes in
T3374 8227-8232 NN denotes IL-10
T3375 8233-8243 NN denotes expression
T3376 8244-8246 IN denotes by
T3377 8247-8250 NN denotes Th1
T3378 8251-8256 NN denotes cells
T3379 8256-8257 -COMMA- denotes ,
T3380 8258-8265 VB denotes showing
T3381 8266-8270 IN denotes that
T3382 8271-8275 DT denotes this
T3383 8276-8286 NN denotes expression
T3384 8287-8290 VB denotes was
T3385 8291-8294 RB denotes not
T3386 8295-8304 JJ denotes dependent
T3387 8305-8307 IN denotes on
T3388 8308-8311 DT denotes the
T3389 8312-8320 NN denotes presence
T3390 8321-8323 IN denotes of
T3391 8324-8332 NN denotes effector
T3392 8333-8335 CC denotes or
T3393 8336-8342 NN denotes memory
T3394 8343-8350 NN denotes T cells
T3395 8351-8353 CC denotes or
T3396 8354-8358 NN denotes Treg
T3397 8359-8364 NN denotes cells
T3398 8365-8366 -LRB- denotes (
T3399 8366-8375 NN denotes Figure S2
T3400 8375-8376 -RRB- denotes )
T3401 8378-8386 IN denotes Although
T3402 8387-8389 PRP denotes it
T3403 8390-8393 VB denotes has
T3404 8394-8398 VB denotes been
T3405 8399-8408 VB denotes suggested
T3406 8409-8413 IN denotes that
T3407 8414-8419 NN denotes TGF-β
T3408 8420-8423 MD denotes can
T3409 8424-8430 VB denotes induce
T3410 8431-8436 NN denotes IL-10
T3411 8437-8439 IN denotes in
T3412 8440-8444 JJ denotes CD4+
T3413 8445-8452 NN denotes T cells
T3414 8453-8454 -LRB- denotes (
T3415 8454-8460 NNP denotes Kitani
T3416 8461-8467 NNP denotes et al.
T3417 8467-8468 -COMMA- denotes ,
T3418 8469-8473 CD denotes 2003
T3419 8473-8474 -COLON- denotes ;
T3420 8475-8482 NNP denotes Schiott
T3421 8483-8489 FW denotes et al.
T3422 8489-8490 -COMMA- denotes ,
T3423 8491-8495 CD denotes 2000
T3424 8495-8496 -RRB- denotes )
T3425 8496-8497 -COMMA- denotes ,
T3426 8498-8500 PRP denotes we
T3427 8501-8506 VB denotes found
T3428 8507-8511 IN denotes that
T3429 8512-8514 IN denotes in
T3430 8515-8525 VB denotes developing
T3431 8526-8529 NN denotes Th1
T3432 8530-8533 CC denotes and
T3433 8534-8537 NN denotes Th2
T3434 8538-8543 NN denotes cells
T3435 8544-8548 DT denotes this
T3436 8549-8552 VB denotes was
T3437 8553-8556 RB denotes not
T3438 8557-8560 DT denotes the
T3439 8561-8565 NN denotes case
T3440 8566-8567 -LRB- denotes (
T3441 8567-8571 NN denotes data
T3442 8572-8575 RB denotes not
T3443 8576-8581 VB denotes shown
T3444 8581-8582 -RRB- denotes )
T3445 8584-8586 IN denotes In
T3446 8587-8591 NN denotes fact
T3447 8591-8592 -COMMA- denotes ,
T3448 8593-8607 NN denotes neutralization
T3449 8608-8610 IN denotes of
T3450 8611-8616 NN denotes TGF-β
T3451 8617-8620 VB denotes led
T3452 8621-8623 TO denotes to
T3453 8624-8633 VB denotes increased
T3454 8634-8639 NN denotes IL-10
T3455 8640-8650 NN denotes production
T3456 8651-8653 IN denotes by
T3457 8654-8658 DT denotes both
T3458 8659-8665 NN denotes T cell
T3459 8666-8673 NN denotes subsets
T3460 8674-8675 -LRB- denotes (
T3461 8675-8684 NN denotes Figure S3
T3462 8684-8685 -RRB- denotes )
T3463 8687-8691 RB denotes Thus
T3464 8691-8692 -COMMA- denotes ,
T3465 8693-8696 DT denotes the
T3466 8697-8708 NN denotes development
T3467 8709-8711 IN denotes of
T3468 8712-8727 JJ denotes IL-10-producing
T3469 8728-8731 NN denotes Th1
T3470 8732-8737 NN denotes cells
T3471 8738-8742 RB denotes only
T3472 8743-8751 VB denotes depended
T3473 8752-8754 IN denotes on
T3474 8755-8758 DT denotes the
T3475 8759-8767 NN denotes presence
T3476 8768-8770 IN denotes of
T3477 8771-8776 NN denotes IL-12
T3478 8777-8785 RB denotes together
T3479 8786-8790 IN denotes with
T3480 8791-8795 JJ denotes high
T3481 8796-8803 NN denotes antigen
T3482 8804-8808 NN denotes dose
T3483 8809-8812 CC denotes and
T3484 8813-8816 RB denotes not
T3485 8817-8819 IN denotes on
T3486 8820-8825 JJ denotes other
T3487 8826-8833 JJ denotes soluble
T3488 8834-8841 NN denotes factors
T3489 8842-8846 JJ denotes such
T3490 8847-8849 IN denotes as
T3491 8850-8854 NN denotes IL-2
T3492 8855-8857 CC denotes or
T3493 8858-8863 NN denotes TGF-β
T3494 8864-8866 CC denotes or
T3495 8867-8869 IN denotes on
T3496 8870-8873 DT denotes the
T3497 8874-8882 NN denotes presence
T3498 8883-8885 IN denotes of
T3499 8886-8891 JJ denotes other
T3500 8892-8898 NN denotes T cell
T3501 8899-8904 NN denotes types
T5036 8907-8912 NN denotes IL-10
T5037 8913-8923 NN denotes Production
T5038 8924-8926 IN denotes by
T5039 8927-8930 NN denotes Th1
T5040 8931-8936 NN denotes Cells
T5041 8937-8939 VB denotes Is
T5042 8940-8949 JJ denotes Dependent
T5043 8950-8952 IN denotes on
T5044 8953-8958 NN denotes STAT4
T5045 8959-8962 CC denotes but
T5046 8963-8966 RB denotes Not
T5047 8967-8969 IN denotes on
T5048 8970-8975 NN denotes STAT6
T5049 8975-8976 -COMMA- denotes ,
T5050 8977-8982 NN denotes IFN-γ
T5051 8982-8983 -COMMA- denotes ,
T5052 8984-8986 CC denotes or
T5053 8987-8991 NN denotes IL-4
T5054 8992-9001 NN denotes Signaling
T5055 9002-9004 TO denotes To
T5056 9005-9012 RB denotes further
T5057 9013-9022 VB denotes elucidate
T5058 9023-9026 DT denotes the
T5059 9027-9037 NN denotes mechanisms
T5060 9038-9046 VB denotes required
T5061 9047-9050 IN denotes for
T5062 9051-9054 DT denotes the
T5063 9055-9066 NN denotes development
T5064 9067-9069 IN denotes of
T5065 9070-9073 NN denotes Th1
T5066 9074-9079 NN denotes cells
T5067 9080-9089 VB denotes producing
T5068 9090-9095 NN denotes IL-10
T5069 9095-9096 -COMMA- denotes ,
T5070 9097-9099 PRP denotes we
T5071 9100-9112 VB denotes investigated
T5072 9113-9116 DT denotes the
T5073 9117-9121 NN denotes role
T5074 9122-9124 IN denotes of
T5075 9125-9130 NN denotes STAT4
T5076 9130-9131 -COMMA- denotes ,
T5077 9132-9135 CD denotes one
T5078 9136-9138 IN denotes of
T5079 9139-9142 DT denotes the
T5080 9143-9152 NN denotes signaling
T5081 9153-9161 NN denotes pathways
T5082 9162-9171 VB denotes activated
T5083 9172-9174 IN denotes by
T5084 9175-9180 NN denotes IL-12
T5085 9181-9182 -LRB- denotes (
T5086 9182-9188 NNP denotes Murphy
T5087 9189-9195 NNP denotes et al.
T5088 9195-9196 -COMMA- denotes ,
T5089 9197-9201 CD denotes 2000
T5090 9201-9202 -RRB- denotes )
T5091 9204-9209 JJ denotes Naive
T5092 9210-9214 JJ denotes CD4+
T5093 9215-9222 NN denotes D011.10
T5094 9223-9230 NN denotes T cells
T5095 9231-9240 JJ denotes deficient
T5096 9241-9243 IN denotes in
T5097 9244-9249 NN denotes STAT4
T5098 9250-9251 -LRB- denotes (
T5099 9251-9257 NNP denotes Ouyang
T5100 9258-9264 NNP denotes et al.
T5101 9264-9265 -COMMA- denotes ,
T5102 9266-9270 CD denotes 1998
T5103 9270-9271 -RRB- denotes )
T5104 9272-9276 VB denotes were
T5105 9277-9285 VB denotes cultured
T5106 9286-9288 IN denotes in
T5107 9289-9292 DT denotes the
T5108 9293-9301 NN denotes presence
T5109 9302-9304 IN denotes of
T5110 9305-9310 NN denotes IL-12
T5111 9311-9314 CC denotes and
T5112 9315-9318 NN denotes OVA
T5113 9320-9325 RB denotes Again
T5114 9325-9326 -COMMA- denotes ,
T5115 9327-9342 JJ denotes IL-10-producing
T5116 9343-9346 NN denotes Th1
T5117 9347-9352 NN denotes cells
T5118 9353-9357 VB denotes were
T5119 9358-9372 VB denotes differentiated
T5120 9373-9375 IN denotes at
T5121 9376-9379 DT denotes the
T5122 9380-9384 JJ denotes high
T5123 9385-9392 NN denotes antigen
T5124 9393-9397 NN denotes dose
T5125 9398-9400 IN denotes in
T5126 9401-9404 DT denotes the
T5127 9405-9413 NN denotes presence
T5128 9414-9416 IN denotes of
T5129 9417-9422 NN denotes IL-12
T5130 9423-9425 IN denotes in
T5131 9426-9433 NN denotes DO11.10
T5132 9434-9441 NN denotes T cells
T5133 9442-9443 -LRB- denotes (
T5134 9443-9452 NN denotes Figure 2A
T5135 9452-9453 -RRB- denotes )
T5136 9455-9457 IN denotes In
T5137 9458-9466 NN denotes contrast
T5138 9466-9467 -COMMA- denotes ,
T5139 9468-9470 IN denotes in
T5140 9471-9474 DT denotes the
T5141 9475-9482 NN denotes absence
T5142 9483-9485 IN denotes of
T5143 9486-9491 NN denotes STAT4
T5144 9491-9492 -COMMA- denotes ,
T5145 9493-9496 DT denotes the
T5146 9497-9507 NN denotes percentage
T5147 9508-9510 IN denotes of
T5148 9511-9516 NN denotes cells
T5149 9517-9527 VB denotes expressing
T5150 9528-9533 NN denotes IFN-γ
T5151 9534-9537 VB denotes was
T5152 9538-9550 RB denotes dramatically
T5153 9551-9561 VB denotes diminished
T5154 9562-9564 IN denotes as
T5155 9565-9573 VB denotes expected
T5156 9574-9577 CC denotes and
T5157 9578-9586 VB denotes resulted
T5158 9587-9589 IN denotes in
T5159 9590-9592 DT denotes an
T5160 9593-9601 NN denotes increase
T5161 9602-9604 IN denotes in
T5162 9605-9608 DT denotes the
T5163 9609-9619 NN denotes percentage
T5164 9620-9622 IN denotes of
T5165 9623-9628 NN denotes cells
T5166 9629-9639 VB denotes expressing
T5167 9640-9644 NN denotes IL-4
T5168 9644-9645 -COMMA- denotes ,
T5169 9646-9649 CC denotes but
T5170 9650-9653 RB denotes not
T5171 9654-9659 NN denotes IL-10
T5172 9660-9661 -LRB- denotes (
T5173 9661-9670 NN denotes Figure 2A
T5174 9670-9671 -RRB- denotes )
T5175 9671-9672 -COMMA- denotes ,
T5176 9673-9683 VB denotes suggesting
T5177 9684-9688 IN denotes that
T5178 9689-9694 NN denotes STAT4
T5179 9695-9706 VB denotes contributes
T5180 9707-9709 TO denotes to
T5181 9710-9715 NN denotes IL-10
T5182 9716-9726 NN denotes expression
T5183 9727-9729 IN denotes by
T5184 9730-9733 NN denotes Th1
T5185 9734-9739 NN denotes cells
T5186 9741-9748 IN denotes Because
T5187 9749-9754 NN denotes IL-10
T5188 9755-9765 NN denotes expression
T5189 9766-9768 VB denotes is
T5190 9769-9779 VB denotes associated
T5191 9780-9784 IN denotes with
T5192 9785-9787 DT denotes an
T5193 9788-9800 JJ denotes IL-4-induced
T5194 9801-9804 NN denotes Th2
T5195 9805-9809 NN denotes cell
T5196 9810-9819 NN denotes phenotype
T5197 9819-9820 -COMMA- denotes ,
T5198 9821-9823 PRP denotes we
T5199 9824-9836 VB denotes investigated
T5200 9837-9844 IN denotes whether
T5201 9845-9848 DT denotes the
T5202 9849-9864 NN denotes differentiation
T5203 9865-9867 IN denotes of
T5204 9868-9871 DT denotes the
T5205 9872-9887 JJ denotes IL-10-producing
T5206 9888-9891 NN denotes Th1
T5207 9892-9897 NN denotes cells
T5208 9898-9906 VB denotes depended
T5209 9907-9909 IN denotes on
T5210 9910-9919 NN denotes signaling
T5211 9920-9927 IN denotes through
T5212 9928-9931 DT denotes the
T5213 9932-9936 NN denotes IL-4
T5214 9937-9945 NN denotes receptor
T5215 9946-9949 IN denotes via
T5216 9950-9955 NN denotes STAT6
T5217 9956-9966 NN denotes activation
T5218 9967-9968 -LRB- denotes (
T5219 9968-9976 NNP denotes Glimcher
T5220 9977-9980 CC denotes and
T5221 9981-9987 NNP denotes Murphy
T5222 9987-9988 -COMMA- denotes ,
T5223 9989-9993 CD denotes 2000
T5224 9993-9994 -COLON- denotes ;
T5225 9995-10001 NNP denotes Murphy
T5226 10002-10008 FW denotes et al.
T5227 10008-10009 -COMMA- denotes ,
T5228 10010-10014 CD denotes 2000
T5229 10014-10015 -RRB- denotes )
T5230 10017-10020 DT denotes The
T5231 10021-10028 NN denotes absence
T5232 10029-10031 IN denotes of
T5233 10032-10037 NN denotes STAT6
T5234 10038-10041 VB denotes did
T5235 10042-10045 RB denotes not
T5236 10046-10052 VB denotes impair
T5237 10053-10056 DT denotes the
T5238 10057-10072 NN denotes differentiation
T5239 10073-10075 IN denotes of
T5240 10076-10091 JJ denotes IL-10-producing
T5241 10092-10095 NN denotes Th1
T5242 10096-10101 NN denotes cells
T5243 10102-10104 IN denotes in
T5244 10105-10108 DT denotes the
T5245 10109-10117 NN denotes presence
T5246 10118-10120 IN denotes of
T5247 10121-10126 NN denotes IL-12
T5248 10127-10130 CC denotes and
T5249 10131-10134 NN denotes OVA
T5250 10135-10136 -LRB- denotes (
T5251 10136-10145 NN denotes Figure 2A
T5252 10145-10146 -RRB- denotes )
T5253 10148-10150 IN denotes In
T5254 10151-10155 NN denotes fact
T5255 10155-10156 -COMMA- denotes ,
T5256 10157-10158 DT denotes a
T5257 10159-10165 JJ denotes higher
T5258 10166-10176 NN denotes percentage
T5259 10177-10179 IN denotes of
T5260 10180-10195 JJ denotes STAT6-deficient
T5261 10196-10201 NN denotes cells
T5262 10202-10210 VB denotes compared
T5263 10211-10215 IN denotes with
T5264 10216-10218 JJ denotes WT
T5265 10219-10224 NN denotes cells
T5266 10225-10233 VB denotes produced
T5267 10234-10238 CC denotes both
T5268 10239-10244 NN denotes IL-10
T5269 10245-10248 CC denotes and
T5270 10249-10254 NN denotes IFN-γ
T5271 10255-10256 -LRB- denotes (
T5272 10256-10265 NN denotes Figure 2A
T5273 10265-10266 -RRB- denotes )
T5274 10266-10267 -COMMA- denotes ,
T5275 10268-10273 WDT denotes which
T5276 10274-10277 MD denotes may
T5277 10278-10280 VB denotes be
T5278 10281-10284 DT denotes the
T5279 10285-10291 NN denotes result
T5280 10292-10294 IN denotes of
T5281 10295-10298 DT denotes the
T5282 10299-10303 NN denotes loss
T5283 10304-10306 IN denotes of
T5284 10307-10310 NN denotes Th2
T5285 10311-10315 NN denotes cell
T5286 10316-10323 NN denotes control
T5287 10324-10328 IN denotes over
T5288 10329-10330 DT denotes a
T5289 10331-10334 NN denotes Th1
T5290 10335-10339 NN denotes cell
T5291 10340-10348 NN denotes response
T5292 10350-10352 IN denotes As
T5293 10353-10361 VB denotes expected
T5294 10361-10362 -COMMA- denotes ,
T5295 10363-10367 NN denotes lack
T5296 10368-10370 IN denotes of
T5297 10371-10376 NN denotes STAT6
T5298 10377-10386 VB denotes abrogated
T5299 10387-10391 CC denotes both
T5300 10392-10396 NN denotes IL-4
T5301 10397-10400 CC denotes and
T5302 10401-10406 NN denotes IL-10
T5303 10407-10417 NN denotes production
T5304 10418-10420 IN denotes by
T5305 10421-10428 NN denotes T cells
T5306 10429-10438 VB denotes developed
T5307 10439-10443 IN denotes with
T5308 10444-10448 NN denotes IL-4
T5309 10449-10451 CC denotes or
T5310 10452-10456 IN denotes with
T5311 10457-10460 JJ denotes low
T5312 10461-10468 NN denotes antigen
T5313 10469-10473 NN denotes dose
T5314 10474-10475 -LRB- denotes (
T5315 10475-10482 NN denotes Figures
T5316 10483-10485 NN denotes 2B
T5317 10486-10489 CC denotes and
T5318 10490-10492 NN denotes 2C
T5319 10492-10493 -RRB- denotes )
T5320 10495-10502 RB denotes However
T5321 10502-10503 -COMMA- denotes ,
T5322 10504-10506 IN denotes in
T5323 10507-10510 DT denotes the
T5324 10511-10518 NN denotes absence
T5325 10519-10521 IN denotes of
T5326 10522-10527 NN denotes STAT4
T5327 10528-10537 NN denotes signaling
T5328 10537-10538 -COMMA- denotes ,
T5329 10539-10544 NN denotes IL-10
T5330 10545-10548 CC denotes and
T5331 10549-10553 NN denotes IL-4
T5332 10554-10564 NN denotes production
T5333 10565-10567 IN denotes by
T5334 10568-10571 NN denotes Th2
T5335 10572-10577 NN denotes cells
T5336 10578-10581 VB denotes was
T5337 10582-10584 IN denotes if
T5338 10585-10593 NN denotes anything
T5339 10594-10603 VB denotes increased
T5340 10604-10605 -LRB- denotes (
T5341 10605-10612 NN denotes Figures
T5342 10613-10615 NN denotes 2B
T5343 10616-10619 CC denotes and
T5344 10620-10622 NN denotes 2C
T5345 10622-10623 -RRB- denotes )
T5346 10625-10629 RB denotes Thus
T5347 10629-10630 -COMMA- denotes ,
T5348 10631-10633 IN denotes in
T5349 10634-10642 NN denotes contrast
T5350 10643-10645 TO denotes to
T5351 10646-10650 WP denotes what
T5352 10651-10654 VB denotes was
T5353 10655-10663 VB denotes observed
T5354 10664-10669 IN denotes under
T5355 10670-10673 NN denotes Th1
T5356 10674-10684 NN denotes conditions
T5357 10684-10685 -COMMA- denotes ,
T5358 10686-10691 NN denotes IL-10
T5359 10692-10702 NN denotes expression
T5360 10703-10705 IN denotes by
T5361 10706-10709 NN denotes Th2
T5362 10710-10715 NN denotes cells
T5363 10716-10724 VB denotes depended
T5364 10725-10727 IN denotes on
T5365 10728-10733 NN denotes STAT6
T5366 10733-10734 -COMMA- denotes ,
T5367 10735-10738 CC denotes but
T5368 10739-10742 RB denotes not
T5369 10743-10745 IN denotes on
T5370 10746-10751 NN denotes STAT4
T5371 10751-10752 -COMMA- denotes ,
T5372 10753-10762 NN denotes signaling
T5373 10763-10764 -LRB- denotes (
T5374 10764-10771 NN denotes Figures
T5375 10772-10774 NN denotes 2B
T5376 10775-10778 CC denotes and
T5377 10779-10781 NN denotes 2C
T5378 10781-10782 -RRB- denotes )
T5379 10784-10786 TO denotes To
T5380 10787-10798 VB denotes investigate
T5381 10799-10806 IN denotes whether
T5382 10807-10810 DT denotes the
T5383 10811-10820 NN denotes inability
T5384 10821-10823 IN denotes of
T5385 10824-10839 JJ denotes STAT4-deficient
T5386 10840-10847 NN denotes T cells
T5387 10848-10850 TO denotes to
T5388 10851-10858 VB denotes produce
T5389 10859-10864 NN denotes IL-10
T5390 10865-10870 MD denotes might
T5391 10871-10873 VB denotes be
T5392 10874-10877 JJ denotes due
T5393 10878-10880 TO denotes to
T5394 10881-10884 DT denotes the
T5395 10885-10892 NN denotes absence
T5396 10893-10895 IN denotes of
T5397 10896-10901 NN denotes IFN-γ
T5398 10901-10902 -COMMA- denotes ,
T5399 10903-10905 IN denotes as
T5400 10906-10915 VB denotes suggested
T5401 10916-10922 IN denotes before
T5402 10923-10924 -LRB- denotes (
T5403 10924-10928 NNP denotes Shaw
T5404 10929-10935 NNP denotes et al.
T5405 10935-10936 -COMMA- denotes ,
T5406 10937-10941 CD denotes 2006
T5407 10941-10942 -RRB- denotes )
T5408 10942-10943 -COMMA- denotes ,
T5409 10944-10946 PRP denotes we
T5410 10947-10961 VB denotes differentiated
T5411 10962-10969 NN denotes DO11.10
T5412 10970-10972 CC denotes or
T5413 10973-10980 NN denotes DO11.10
T5414 10981-10996 JJ denotes IFN-γ-deficient
T5415 10997-11002 JJ denotes naive
T5416 11003-11007 JJ denotes CD4+
T5417 11008-11015 NN denotes T cells
T5418 11016-11018 IN denotes in
T5419 11019-11022 DT denotes the
T5420 11023-11031 NN denotes presence
T5421 11032-11034 IN denotes of
T5422 11035-11040 NN denotes IL-12
T5423 11041-11044 CC denotes and
T5424 11045-11055 VB denotes increasing
T5425 11056-11061 NN denotes doses
T5426 11062-11064 IN denotes of
T5427 11065-11068 NN denotes OVA
T5428 11070-11073 DT denotes The
T5429 11074-11083 NN denotes secretion
T5430 11084-11086 IN denotes of
T5431 11087-11092 NN denotes IL-10
T5432 11093-11095 IN denotes as
T5433 11096-11103 VB denotes induced
T5434 11104-11106 IN denotes by
T5435 11107-11111 JJ denotes high
T5436 11112-11119 NN denotes antigen
T5437 11120-11124 NN denotes dose
T5438 11124-11125 -COMMA- denotes ,
T5439 11126-11129 CC denotes and
T5440 11130-11135 NN denotes IL-12
T5441 11136-11139 VB denotes was
T5442 11140-11143 RB denotes not
T5443 11144-11152 VB denotes affected
T5444 11153-11155 IN denotes by
T5445 11156-11158 DT denotes an
T5446 11159-11166 NN denotes absence
T5447 11167-11169 IN denotes of
T5448 11170-11175 NN denotes IFN-γ
T5449 11176-11177 -LRB- denotes (
T5450 11177-11186 NN denotes Figure 2D
T5451 11186-11187 -RRB- denotes )
T5452 11187-11188 -COMMA- denotes ,
T5453 11189-11196 VB denotes showing
T5454 11197-11201 IN denotes that
T5455 11202-11205 DT denotes the
T5456 11206-11216 NN denotes expression
T5457 11217-11225 NN denotes of IL-10
T5458 11226-11228 IN denotes by
T5459 11229-11232 NN denotes Th1
T5460 11233-11238 NN denotes cells
T5461 11239-11241 VB denotes is
T5462 11242-11253 JJ denotes independent
T5463 11254-11256 IN denotes of
T5464 11257-11262 NN denotes IFN-γ
T5465 11264-11266 IN denotes In
T5466 11267-11270 DT denotes the
T5467 11271-11278 NN denotes absence
T5468 11279-11281 IN denotes of
T5469 11282-11287 NN denotes IFN-γ
T5470 11287-11288 -COMMA- denotes ,
T5471 11289-11291 PRP denotes we
T5472 11292-11300 VB denotes observed
T5473 11301-11303 DT denotes an
T5474 11304-11312 NN denotes increase
T5475 11313-11315 IN denotes in
T5476 11316-11319 DT denotes the
T5477 11320-11328 VB denotes secreted
T5478 11329-11333 NN denotes IL-4
T5479 11334-11336 IN denotes as
T5480 11337-11345 VB denotes expected
T5481 11346-11347 -LRB- denotes (
T5482 11347-11351 NN denotes data
T5483 11352-11355 RB denotes not
T5484 11356-11361 VB denotes shown
T5485 11361-11362 -RRB- denotes )
T5486 11364-11366 PRP denotes We
T5487 11367-11371 RB denotes also
T5488 11372-11378 VB denotes tested
T5489 11379-11382 IN denotes for
T5490 11383-11386 DT denotes any
T5491 11387-11396 JJ denotes potential
T5492 11397-11401 NN denotes role
T5493 11402-11404 IN denotes of
T5494 11405-11409 NN denotes IL-4
T5495 11410-11412 IN denotes in
T5496 11413-11416 DT denotes the
T5497 11417-11428 NN denotes development
T5498 11429-11431 IN denotes of
T5499 11432-11435 NN denotes Th1
T5500 11436-11441 NN denotes cells
T5501 11442-11451 VB denotes producing
T5502 11452-11457 NN denotes IL-10
T5503 11458-11460 IN denotes by
T5504 11461-11470 VB denotes culturing
T5505 11471-11478 NN denotes DO11.10
T5506 11479-11481 CC denotes or
T5507 11482-11489 NN denotes DO11.10
T5508 11490-11504 JJ denotes IL-4-deficient
T5509 11505-11510 JJ denotes naive
T5510 11511-11515 JJ denotes CD4+
T5511 11516-11523 NN denotes T cells
T5512 11524-11528 IN denotes with
T5513 11529-11534 NN denotes IL-12
T5514 11535-11538 CC denotes and
T5515 11539-11549 VB denotes increasing
T5516 11550-11555 NN denotes doses
T5517 11556-11558 IN denotes of
T5518 11559-11566 NN denotes antigen
T5519 11568-11570 IN denotes As
T5520 11571-11579 VB denotes observed
T5521 11580-11582 IN denotes in
T5522 11583-11586 DT denotes the
T5523 11587-11594 NN denotes absence
T5524 11595-11597 IN denotes of
T5525 11598-11603 NN denotes STAT6
T5526 11604-11605 -LRB- denotes (
T5527 11605-11614 NN denotes Figure 2A
T5528 11614-11615 -RRB- denotes )
T5529 11615-11616 -COMMA- denotes ,
T5530 11617-11621 NN denotes IL-4
T5531 11622-11632 NN denotes deficiency
T5532 11633-11636 VB denotes had
T5533 11637-11639 DT denotes no
T5534 11640-11646 NN denotes effect
T5535 11647-11649 IN denotes on
T5536 11650-11653 DT denotes the
T5537 11654-11665 NN denotes development
T5538 11666-11668 IN denotes of
T5539 11669-11672 NN denotes Th1
T5540 11673-11678 NN denotes cells
T5541 11679-11688 VB denotes producing
T5542 11689-11694 NN denotes IL-10
T5543 11695-11696 -LRB- denotes (
T5544 11696-11705 NN denotes Figure 2E
T5545 11705-11706 -RRB- denotes )
T5546 11706-11707 -COMMA- denotes ,
T5547 11708-11711 CC denotes but
T5548 11712-11723 VB denotes compromised
T5549 11724-11727 DT denotes the
T5550 11728-11739 NN denotes development
T5551 11740-11742 IN denotes of
T5552 11743-11746 NN denotes Th2
T5553 11747-11752 NN denotes cells
T5554 11753-11762 VB denotes producing
T5555 11763-11768 NN denotes IL-10
T5556 11769-11770 -LRB- denotes (
T5557 11770-11779 NN denotes Figure 2F
T5558 11779-11780 -RRB- denotes )
T5559 11782-11786 RB denotes Thus
T5560 11786-11787 -COMMA- denotes ,
T5561 11788-11791 PRP-DOLLAR- denotes our
T5562 11792-11796 NN denotes data
T5563 11797-11806 VB denotes suggested
T5564 11807-11811 IN denotes that
T5565 11812-11817 NN denotes IL-10
T5566 11818-11828 NN denotes production
T5567 11829-11831 IN denotes by
T5568 11832-11835 NN denotes Th1
T5569 11836-11838 CC denotes or
T5570 11839-11842 NN denotes Th2
T5571 11843-11848 NN denotes cells
T5572 11849-11852 VB denotes was
T5573 11853-11862 JJ denotes dependent
T5574 11863-11865 IN denotes on
T5575 11866-11869 DT denotes the
T5576 11870-11878 JJ denotes specific
T5577 11879-11888 NN denotes signaling
T5578 11889-11897 NN denotes pathways
T5579 11898-11906 VB denotes required
T5580 11907-11910 IN denotes for
T5581 11911-11916 PRP-DOLLAR- denotes their
T5582 11917-11932 NN denotes differentiation
T5583 11932-11933 -COMMA- denotes ,
T5584 11934-11939 VB denotes given
T5585 11940-11944 IN denotes that
T5586 11945-11950 NN denotes STAT4
T5587 11951-11953 VB denotes is
T5588 11954-11962 VB denotes required
T5589 11963-11966 IN denotes for
T5590 11967-11970 DT denotes the
T5591 11971-11980 NN denotes induction
T5592 11981-11983 IN denotes of
T5593 11984-11989 NN denotes IL-10
T5594 11990-12000 NN denotes production
T5595 12001-12003 IN denotes by
T5596 12004-12007 NN denotes Th1
T5597 12008-12013 NN denotes cells
T5598 12014-12017 CC denotes and
T5599 12018-12023 NN denotes STAT6
T5600 12024-12027 IN denotes for
T5601 12028-12031 NN denotes Th2
T5602 12032-12037 NN denotes cells
T7042 12040-12044 JJ denotes High
T7043 12045-12052 NN denotes Antigen
T7044 12053-12058 NN denotes Doses
T7045 12059-12062 CC denotes and
T7046 12063-12068 NN denotes STAT4
T7047 12069-12072 VB denotes Are
T7048 12073-12081 VB denotes Required
T7049 12082-12085 IN denotes for
T7050 12086-12089 DT denotes the
T7051 12090-12092 NNP denotes In
T7052 12093-12097 NNP denotes Vivo
T7053 12098-12108 NNP denotes Generation
T7054 12109-12111 IN denotes of
T7055 12112-12127 JJ denotes IL-10-Producing
T7056 12128-12131 NN denotes Th1
T7057 12132-12137 NN denotes Cells
T7058 12138-12140 TO denotes To
T7059 12141-12148 VB denotes address
T7060 12149-12152 DT denotes the
T7061 12153-12163 NN denotes mechanisms
T7062 12164-12174 VB denotes regulating
T7063 12175-12180 NN denotes IL-10
T7064 12181-12191 NN denotes production
T7065 12192-12194 IN denotes by
T7066 12195-12198 NN denotes Th1
T7067 12199-12204 NN denotes cells
T7068 12205-12212 FW denotes in vivo
T7069 12212-12213 -COMMA- denotes ,
T7070 12214-12216 PRP denotes we
T7071 12217-12228 VB denotes transferred
T7072 12229-12236 NN denotes DO11.10
T7073 12237-12242 NN denotes cells
T7074 12243-12247 IN denotes into
T7075 12248-12254 NN denotes BALB/c
T7076 12255-12264 NN denotes recipient
T7077 12265-12269 NN denotes mice
T7078 12270-12273 CC denotes and
T7079 12274-12283 VB denotes immunized
T7080 12284-12287 DT denotes the
T7081 12288-12298 NN denotes recipients
T7082 12299-12303 IN denotes with
T7083 12304-12308 RB denotes very
T7084 12309-12313 JJ denotes high
T7085 12314-12319 NN denotes doses
T7086 12320-12322 IN denotes of
T7087 12323-12334 NN denotes OVA-protein
T7088 12335-12339 IN denotes with
T7089 12340-12342 CC denotes or
T7090 12343-12350 IN denotes without
T7091 12351-12356 VB denotes added
T7092 12357-12374 NN denotes lipopolysacharide
T7093 12375-12376 -LRB- denotes (
T7094 12376-12379 NN denotes LPS
T7095 12379-12380 -RRB- denotes )
T7096 12382-12389 NN denotes T cells
T7097 12390-12394 VB denotes were
T7098 12395-12404 VB denotes recovered
T7099 12405-12409 IN denotes from
T7100 12410-12413 DT denotes the
T7101 12414-12422 JJ denotes inguinal
T7102 12423-12428 NN denotes lymph
T7103 12429-12434 NN denotes nodes
T7104 12435-12436 CD denotes 3
T7105 12437-12441 NN denotes days
T7106 12442-12447 IN denotes after
T7107 12448-12455 NN denotes priming
T7108 12456-12459 CC denotes and
T7109 12460-12472 VB denotes restimulated
T7110 12473-12481 FW denotes in vitro
T7111 12482-12486 IN denotes with
T7112 12487-12490 NN denotes OVA
T7113 12491-12498 NN denotes peptide
T7114 12499-12502 IN denotes for
T7115 12503-12505 CD denotes 48
T7116 12506-12508 NN denotes hr
T7117 12510-12514 DT denotes This
T7118 12515-12522 FW denotes in vivo
T7119 12523-12535 NN denotes immunization
T7120 12536-12543 VB denotes induced
T7121 12544-12549 NN denotes IL-10
T7122 12550-12553 CC denotes and
T7123 12554-12559 NN denotes IFN-γ
T7124 12560-12570 NN denotes production
T7125 12570-12571 -COMMA- denotes ,
T7126 12572-12575 CC denotes and
T7127 12576-12579 DT denotes the
T7128 12580-12586 NN denotes amount
T7129 12587-12589 IN denotes of
T7130 12590-12595 NN denotes IL-10
T7131 12596-12606 NN denotes production
T7132 12607-12610 VB denotes was
T7133 12611-12619 VB denotes enhanced
T7134 12620-12622 IN denotes by
T7135 12623-12631 NN denotes addition
T7136 12632-12634 IN denotes of
T7137 12635-12638 NN denotes LPS
T7138 12639-12641 IN denotes in
T7139 12642-12645 DT denotes the
T7140 12646-12658 NN denotes immunization
T7141 12659-12660 -LRB- denotes (
T7142 12660-12669 NN denotes Figure 3A
T7143 12669-12670 -RRB- denotes )
T7144 12671-12674 CC denotes and
T7145 12675-12679 IN denotes with
T7146 12680-12686 JJ denotes higher
T7147 12687-12692 NN denotes doses
T7148 12693-12695 IN denotes of
T7149 12696-12699 NN denotes OVA
T7150 12700-12701 -LRB- denotes (
T7151 12701-12702 CD denotes 3
T7152 12703-12705 NN denotes μM
T7153 12706-12712 IN denotes versus
T7154 12713-12714 CD denotes 1
T7155 12715-12717 NN denotes μM
T7156 12717-12718 -COMMA- denotes ,
T7157 12719-12723 NN denotes data
T7158 12724-12727 RB denotes not
T7159 12728-12733 VB denotes shown
T7160 12733-12734 -RRB- denotes )
T7161 12736-12738 TO denotes To
T7162 12739-12743 VB denotes test
T7163 12744-12747 DT denotes the
T7164 12748-12752 NN denotes role
T7165 12753-12755 IN denotes of
T7166 12756-12761 NN denotes STAT4
T7167 12762-12765 CC denotes and
T7168 12766-12771 NN denotes STAT6
T7169 12772-12781 NN denotes signaling
T7170 12782-12784 IN denotes in
T7171 12785-12788 DT denotes the
T7172 12789-12796 FW denotes in vivo
T7173 12797-12808 NN denotes development
T7174 12809-12811 IN denotes of
T7175 12812-12827 JJ denotes IL-10-producing
T7176 12828-12831 NN denotes Th1
T7177 12832-12837 NN denotes cells
T7178 12837-12838 -COMMA- denotes ,
T7179 12839-12841 PRP denotes we
T7180 12842-12853 VB denotes transferred
T7181 12854-12860 NN denotes STAT4-
T7182 12861-12863 CC denotes or
T7183 12864-12879 JJ denotes STAT6-deficient
T7184 12880-12882 CC denotes or
T7185 12883-12885 JJ denotes WT
T7186 12886-12893 NN denotes DO11.10
T7187 12894-12899 NN denotes cells
T7188 12900-12904 IN denotes into
T7189 12905-12914 JJ denotes recipient
T7190 12915-12921 NN denotes BALB/c
T7191 12922-12926 NN denotes mice
T7192 12927-12930 CC denotes and
T7193 12931-12940 VB denotes immunized
T7194 12941-12945 IN denotes with
T7195 12946-12957 NN denotes OVA-protein
T7196 12958-12962 CC denotes plus
T7197 12963-12966 NN denotes LPS
T7198 12967-12969 IN denotes as
T7199 12970-12976 RB denotes before
T7200 12978-12980 FW denotes In
T7201 12981-12985 FW denotes vivo
T7202 12986-12996 NN denotes expression
T7203 12997-12999 IN denotes of
T7204 13000-13004 CC denotes both
T7205 13005-13010 NN denotes IL-10
T7206 13011-13014 CC denotes and
T7207 13015-13020 NN denotes IFN-γ
T7208 13021-13024 VB denotes was
T7209 13025-13033 RB denotes markedly
T7210 13034-13041 VB denotes reduced
T7211 13042-13045 CC denotes but
T7212 13046-13049 RB denotes not
T7213 13050-13060 RB denotes completely
T7214 13061-13070 VB denotes abrogated
T7215 13071-13073 IN denotes in
T7216 13074-13077 DT denotes the
T7217 13078-13085 NN denotes absence
T7218 13086-13088 IN denotes of
T7219 13089-13094 NN denotes STAT4
T7220 13095-13104 NN denotes signaling
T7221 13105-13106 -LRB- denotes (
T7222 13106-13113 NN denotes Figures
T7223 13114-13116 NN denotes 3B
T7224 13117-13120 CC denotes and
T7225 13121-13123 NN denotes 3C
T7226 13123-13124 -RRB- denotes )
T7227 13124-13125 -COMMA- denotes ,
T7228 13126-13136 VB denotes suggesting
T7229 13137-13140 DT denotes the
T7230 13141-13150 NN denotes existence
T7231 13151-13153 IN denotes of
T7232 13154-13166 JJ denotes compensatory
T7233 13167-13177 NN denotes mechanisms
T7234 13178-13182 WDT denotes that
T7235 13183-13187 VB denotes were
T7236 13188-13194 JJ denotes absent
T7237 13195-13197 IN denotes in
T7238 13198-13201 DT denotes the
T7239 13202-13210 FW denotes in vitro
T7240 13211-13217 NN denotes system
T7241 13219-13228 VB denotes Signaling
T7242 13229-13236 IN denotes through
T7243 13237-13242 NN denotes STAT6
T7244 13243-13246 VB denotes had
T7245 13247-13249 DT denotes no
T7246 13250-13256 NN denotes effect
T7247 13257-13259 IN denotes on
T7248 13260-13265 NN denotes IL-10
T7249 13266-13276 NN denotes production
T7250 13277-13279 IN denotes by
T7251 13280-13283 NN denotes Th1
T7252 13284-13289 NN denotes cells
T7253 13290-13292 IN denotes as
T7254 13293-13298 VB denotes shown
T7255 13299-13301 IN denotes by
T7256 13302-13315 JJ denotes intracellular
T7257 13316-13324 NN denotes cytokine
T7258 13325-13333 NN denotes staining
T7259 13334-13335 -LRB- denotes (
T7260 13335-13338 NN denotes ICS
T7261 13338-13339 -RRB- denotes )
T7262 13340-13343 CC denotes and
T7263 13344-13346 IN denotes by
T7264 13347-13358 NN denotes immunoassay
T7265 13359-13361 IN denotes in
T7266 13362-13377 JJ denotes STAT6-deficient
T7267 13378-13385 NN denotes T cells
T7268 13386-13387 -LRB- denotes (
T7269 13387-13394 NN denotes Figures
T7270 13395-13397 NN denotes 3B
T7271 13398-13401 CC denotes and
T7272 13402-13404 NN denotes 3C
T7273 13404-13405 -RRB- denotes )
T7938 13408-13413 NN denotes IL-10
T7939 13414-13424 NN denotes Production
T7940 13425-13427 VB denotes Is
T7941 13428-13438 VB denotes Maintained
T7942 13439-13441 IN denotes by
T7943 13442-13446 JJ denotes High
T7944 13447-13450 NN denotes TCR
T7945 13451-13457 NN denotes Signal
T7946 13458-13466 NN denotes Strength
T7947 13467-13470 CC denotes and
T7948 13471-13476 NN denotes IL-12
T7949 13477-13479 PRP denotes We
T7950 13480-13484 RB denotes next
T7951 13485-13497 VB denotes investigated
T7952 13498-13505 IN denotes whether
T7953 13506-13514 VB denotes repeated
T7954 13515-13521 JJ denotes strong
T7955 13522-13525 NN denotes TCR
T7956 13526-13536 NN denotes activation
T7957 13537-13539 VB denotes is
T7958 13540-13541 DT denotes a
T7959 13542-13554 JJ denotes compensatory
T7960 13555-13561 NN denotes signal
T7961 13562-13565 IN denotes for
T7962 13566-13579 JJ denotes IL-12-induced
T7963 13580-13585 NN denotes STAT4
T7964 13586-13595 NN denotes signaling
T7965 13596-13598 IN denotes in
T7966 13599-13602 DT denotes the
T7967 13603-13612 NN denotes induction
T7968 13613-13615 IN denotes of
T7969 13616-13621 NN denotes IL-10
T7970 13622-13624 IN denotes in
T7971 13625-13628 NN denotes Th1
T7972 13629-13634 NN denotes cells
T7973 13636-13639 IN denotes For
T7974 13640-13644 DT denotes this
T7975 13644-13645 -COMMA- denotes ,
T7976 13646-13650 JJ denotes CD4+
T7977 13651-13658 NN denotes T cells
T7978 13659-13663 VB denotes were
T7979 13664-13678 VB denotes differentiated
T7980 13679-13682 IN denotes for
T7981 13683-13684 CD denotes 2
T7982 13685-13696 JJ denotes consecutive
T7983 13697-13702 NN denotes weeks
T7984 13703-13707 IN denotes with
T7985 13708-13712 JJ denotes high
T7986 13713-13720 NN denotes antigen
T7987 13721-13726 NN denotes doses
T7988 13727-13729 IN denotes in
T7989 13730-13733 DT denotes the
T7990 13734-13742 NN denotes presence
T7991 13743-13745 CC denotes or
T7992 13746-13753 NN denotes absence
T7993 13754-13756 IN denotes of
T7994 13757-13762 NN denotes IL-12
T7995 13763-13773 IN denotes throughout
T7996 13774-13775 -LRB- denotes (
T7997 13775-13782 NN denotes Figures
T7998 13783-13788 NN denotes 4A–4D
T7999 13788-13789 -RRB- denotes )
T8000 13791-13795 JJ denotes High
T8001 13796-13803 NN denotes antigen
T8002 13804-13808 NN denotes dose
T8003 13809-13812 CC denotes and
T8004 13813-13818 NN denotes IL-12
T8005 13819-13829 VB denotes cooperated
T8006 13830-13832 TO denotes to
T8007 13833-13839 VB denotes induce
T8008 13840-13847 JJ denotes maximal
T8009 13848-13853 NN denotes IL-10
T8010 13854-13864 NN denotes production
T8011 13865-13866 -LRB- denotes (
T8012 13866-13873 NN denotes Figures
T8013 13874-13876 NN denotes 4A
T8014 13877-13880 CC denotes and
T8015 13881-13883 NN denotes 4B
T8016 13883-13884 -RRB- denotes )
T8017 13884-13885 -COMMA- denotes ,
T8018 13886-13891 VB denotes given
T8019 13892-13896 IN denotes that
T8020 13897-13901 DT denotes this
T8021 13902-13913 NN denotes combination
T8022 13914-13922 VB denotes resulted
T8023 13923-13925 IN denotes in
T8024 13926-13929 DT denotes the
T8025 13930-13937 JJ denotes highest
T8026 13938-13945 NN denotes numbers
T8027 13946-13948 IN denotes of
T8028 13949-13964 JJ denotes IL-10-producing
T8029 13965-13968 NN denotes Th1
T8030 13969-13974 NN denotes cells
T8031 13976-13984 VB denotes Repeated
T8032 13985-13989 JJ denotes high
T8033 13990-13997 NN denotes antigen
T8034 13998-14002 NN denotes dose
T8035 14003-14014 NN denotes stimulation
T8036 14015-14017 IN denotes in
T8037 14018-14021 DT denotes the
T8038 14022-14029 NN denotes absence
T8039 14030-14032 IN denotes of
T8040 14033-14044 RB denotes exogenously
T8041 14045-14050 VB denotes added
T8042 14051-14056 NN denotes IL-12
T8043 14057-14065 VB denotes resulted
T8044 14066-14068 IN denotes in
T8045 14069-14072 DT denotes the
T8046 14073-14083 NN denotes production
T8047 14084-14086 IN denotes of
T8048 14087-14092 NN denotes IL-10
T8049 14093-14095 IN denotes by
T8050 14096-14099 NN denotes Th1
T8051 14100-14105 NN denotes cells
T8052 14105-14106 -COMMA- denotes ,
T8053 14107-14117 VB denotes suggesting
T8054 14118-14122 IN denotes that
T8055 14123-14131 VB denotes repeated
T8056 14132-14138 JJ denotes strong
T8057 14139-14142 NN denotes TCR
T8058 14143-14153 NN denotes triggering
T8059 14154-14157 MD denotes may
T8060 14158-14166 VB denotes overcome
T8061 14167-14170 DT denotes the
T8062 14171-14175 NN denotes need
T8063 14176-14179 IN denotes for
T8064 14180-14185 NN denotes IL-12
T8065 14186-14189 IN denotes for
T8066 14190-14195 NN denotes IL-10
T8067 14196-14205 NN denotes induction
T8068 14206-14207 -LRB- denotes (
T8069 14207-14214 NN denotes Figures
T8070 14215-14217 NN denotes 4C
T8071 14218-14221 CC denotes and
T8072 14222-14224 NN denotes 4D
T8073 14224-14225 -RRB- denotes )
T8074 14227-14234 RB denotes However
T8075 14234-14235 -COMMA- denotes ,
T8076 14236-14241 NN denotes IL-10
T8077 14242-14251 NN denotes induction
T8078 14252-14257 IN denotes under
T8079 14258-14263 DT denotes these
T8080 14264-14274 NN denotes conditions
T8081 14275-14278 VB denotes was
T8082 14279-14288 VB denotes abrogated
T8083 14289-14293 WRB denotes when
T8084 14294-14312 JJ denotes IL-12p40-deficient
T8085 14313-14316 NN denotes DCs
T8086 14317-14321 VB denotes were
T8087 14322-14326 VB denotes used
T8088 14327-14329 IN denotes as
T8089 14330-14334 NN denotes APCs
T8090 14335-14336 -LRB- denotes (
T8091 14336-14345 NN denotes Figure 4E
T8092 14345-14346 -RRB- denotes )
T8093 14348-14352 RB denotes Thus
T8094 14352-14353 -COMMA- denotes ,
T8095 14354-14359 NN denotes IL-12
T8096 14360-14362 VB denotes is
T8097 14363-14372 JJ denotes essential
T8098 14373-14379 IN denotes during
T8099 14380-14384 CC denotes both
T8100 14385-14392 JJ denotes primary
T8101 14393-14396 CC denotes and
T8102 14397-14406 JJ denotes secondary
T8103 14407-14416 JJ denotes antigenic
T8104 14417-14428 NN denotes stimulation
T8105 14429-14432 IN denotes for
T8106 14433-14443 NN denotes production
T8107 14444-14446 IN denotes of
T8108 14447-14452 NN denotes IL-10
T8109 14453-14455 IN denotes by
T8110 14456-14459 NN denotes Th1
T8111 14460-14465 NN denotes cells
T8112 14467-14469 TO denotes To
T8113 14470-14479 VB denotes determine
T8114 14480-14483 DT denotes the
T8115 14484-14496 NN denotes requirements
T8116 14497-14500 IN denotes for
T8117 14501-14510 NN denotes stability
T8118 14511-14513 IN denotes of
T8119 14514-14517 DT denotes the
T8120 14518-14533 JJ denotes IL-10-producing
T8121 14534-14537 NN denotes Th1
T8122 14538-14543 NN denotes cells
T8123 14543-14544 -COMMA- denotes ,
T8124 14545-14547 PRP denotes we
T8125 14548-14562 VB denotes differentiated
T8126 14563-14567 JJ denotes CD4+
T8127 14568-14575 NN denotes T cells
T8128 14576-14579 IN denotes for
T8129 14580-14581 CD denotes 1
T8130 14582-14586 NN denotes week
T8131 14587-14591 IN denotes with
T8132 14592-14596 JJ denotes high
T8133 14597-14604 NN denotes antigen
T8134 14605-14610 NN denotes doses
T8135 14611-14615 IN denotes with
T8136 14616-14618 CC denotes or
T8137 14619-14626 IN denotes without
T8138 14627-14632 NN denotes IL-12
T8139 14633-14634 -LRB- denotes (
T8140 14634-14641 NN denotes Figures
T8141 14642-14644 NN denotes 4A
T8142 14645-14648 CC denotes and
T8143 14649-14651 NN denotes 4C
T8144 14651-14652 -RRB- denotes )
T8145 14652-14653 -COMMA- denotes ,
T8146 14654-14660 VB denotes washed
T8147 14661-14665 PRP denotes them
T8148 14665-14666 -COMMA- denotes ,
T8149 14667-14670 CC denotes and
T8150 14671-14675 RB denotes then
T8151 14676-14688 VB denotes restimulated
T8152 14689-14693 PRP denotes them
T8153 14694-14697 IN denotes for
T8154 14698-14700 DT denotes an
T8155 14701-14711 JJ denotes additional
T8156 14712-14716 NN denotes week
T8157 14717-14721 IN denotes with
T8158 14722-14723 DT denotes a
T8159 14724-14727 JJ denotes low
T8160 14728-14735 NN denotes antigen
T8161 14736-14740 NN denotes dose
T8162 14740-14741 -COMMA- denotes ,
T8163 14742-14744 IN denotes in
T8164 14745-14748 DT denotes the
T8165 14749-14756 NN denotes absence
T8166 14757-14759 CC denotes or
T8167 14760-14768 NN denotes presence
T8168 14769-14771 IN denotes of
T8169 14772-14777 NN denotes IL-12
T8170 14778-14779 -LRB- denotes (
T8171 14779-14788 NN denotes Figure 4F
T8172 14788-14789 -RRB- denotes )
T8173 14791-14794 NN denotes Th1
T8174 14795-14800 NN denotes cells
T8175 14801-14808 VB denotes induced
T8176 14809-14811 IN denotes in
T8177 14812-14815 DT denotes the
T8178 14816-14821 JJ denotes first
T8179 14822-14826 NN denotes week
T8180 14827-14829 TO denotes to
T8181 14830-14837 VB denotes produce
T8182 14838-14843 NN denotes IL-10
T8183 14844-14846 IN denotes by
T8184 14847-14854 NN denotes culture
T8185 14855-14859 IN denotes with
T8186 14860-14864 JJ denotes high
T8187 14865-14872 NN denotes antigen
T8188 14873-14878 NN denotes doses
T8189 14879-14882 CC denotes and
T8190 14883-14888 NN denotes IL-12
T8191 14889-14893 VB denotes lost
T8192 14894-14899 PRP-DOLLAR- denotes their
T8193 14900-14907 NN denotes ability
T8194 14908-14910 TO denotes to
T8195 14911-14918 VB denotes express
T8196 14919-14924 NN denotes IL-10
T8197 14925-14929 WRB denotes when
T8198 14930-14940 VB denotes recultured
T8199 14941-14945 IN denotes with
T8200 14946-14949 JJ denotes low
T8201 14950-14955 NN denotes doses
T8202 14956-14958 IN denotes of
T8203 14959-14962 NN denotes OVA
T8204 14962-14963 -COMMA- denotes ,
T8205 14964-14969 WDT denotes which
T8206 14970-14975 MD denotes could
T8207 14976-14978 VB denotes be
T8208 14979-14990 VB denotes compensated
T8209 14991-14994 IN denotes for
T8210 14994-14995 -COMMA- denotes ,
T8211 14996-14998 TO denotes to
T8212 14999-15003 DT denotes some
T8213 15004-15010 NN denotes extent
T8214 15010-15011 -COMMA- denotes ,
T8215 15012-15014 IN denotes by
T8216 15015-15023 NN denotes addition
T8217 15024-15026 IN denotes of
T8218 15027-15032 NN denotes IL-12
T8219 15033-15035 TO denotes to
T8220 15036-15039 DT denotes the
T8221 15040-15049 JJ denotes secondary
T8222 15050-15058 NN denotes cultures
T8223 15059-15060 -LRB- denotes (
T8224 15060-15069 NN denotes Figure 4F
T8225 15069-15070 -RRB- denotes )
T8226 15070-15071 -COMMA- denotes ,
T8227 15072-15077 RB denotes again
T8228 15078-15088 VB denotes suggesting
T8229 15089-15093 IN denotes that
T8230 15094-15101 NN denotes antigen
T8231 15102-15106 NN denotes dose
T8232 15107-15110 CC denotes and
T8233 15111-15116 NN denotes IL-12
T8234 15117-15124 NN denotes signals
T8235 15125-15134 VB denotes cooperate
T8236 15135-15138 IN denotes for
T8237 15139-15142 DT denotes the
T8238 15143-15152 NN denotes induction
T8239 15153-15155 IN denotes of
T8240 15156-15161 NN denotes IL-10
T8241 15163-15170 RB denotes Finally
T8242 15170-15171 -COMMA- denotes ,
T8243 15172-15179 NN denotes DO11.10
T8244 15180-15184 JJ denotes CD4+
T8245 15185-15190 NN denotes cells
T8246 15191-15195 WDT denotes that
T8247 15196-15200 VB denotes were
T8248 15201-15208 VB denotes exposed
T8249 15209-15211 TO denotes to
T8250 15212-15215 JJ denotes low
T8251 15216-15221 NN denotes doses
T8252 15222-15224 IN denotes of
T8253 15225-15232 NN denotes antigen
T8254 15233-15236 CC denotes and
T8255 15237-15242 NN denotes IL-12
T8256 15243-15249 IN denotes during
T8257 15250-15253 DT denotes the
T8258 15254-15261 JJ denotes primary
T8259 15262-15277 NN denotes differentiation
T8260 15278-15283 NN denotes phase
T8261 15284-15292 VB denotes produced
T8262 15293-15297 JJ denotes high
T8263 15298-15305 NN denotes amounts
T8264 15306-15308 IN denotes of
T8265 15309-15314 NN denotes IFN-γ
T8266 15315-15318 CC denotes but
T8267 15319-15325 JJ denotes little
T8268 15326-15331 NN denotes IL-10
T8269 15331-15332 -COMMA- denotes ,
T8270 15333-15336 CC denotes but
T8271 15337-15341 PRP denotes they
T8272 15342-15347 MD denotes could
T8273 15348-15350 VB denotes be
T8274 15351-15358 VB denotes induced
T8275 15359-15361 TO denotes to
T8276 15362-15369 VB denotes produce
T8277 15370-15375 NN denotes IL-10
T8278 15376-15380 WRB denotes when
T8279 15381-15385 CC denotes both
T8280 15386-15390 JJ denotes high
T8281 15391-15398 NN denotes antigen
T8282 15399-15403 NN denotes dose
T8283 15404-15407 CC denotes and
T8284 15408-15413 NN denotes IL-12
T8285 15414-15418 VB denotes were
T8286 15419-15426 JJ denotes present
T8287 15427-15433 IN denotes during
T8288 15434-15437 DT denotes the
T8289 15438-15444 NN denotes recall
T8290 15445-15450 NN denotes phase
T8291 15451-15452 -LRB- denotes (
T8292 15452-15461 NN denotes Figure S4
T8293 15461-15462 -RRB- denotes )
T8294 15464-15468 RB denotes Thus
T8295 15468-15469 -COMMA- denotes ,
T8296 15470-15474 JJ denotes high
T8297 15475-15482 NN denotes antigen
T8298 15483-15487 NN denotes dose
T8299 15488-15491 CC denotes and
T8300 15492-15497 NN denotes IL-12
T8301 15498-15501 VB denotes are
T8302 15502-15510 VB denotes required
T8303 15511-15514 IN denotes for
T8304 15515-15525 VB denotes sustaining
T8305 15526-15529 DT denotes the
T8306 15530-15539 NN denotes induction
T8307 15540-15542 IN denotes of
T8308 15543-15548 NN denotes IL-10
T8309 15549-15559 NN denotes production
T8310 15560-15562 IN denotes by
T8311 15563-15566 NN denotes Th1
T8312 15567-15572 NN denotes cells
T9392 15575-15580 NN denotes IL-10
T9393 15581-15591 NN denotes Production
T9394 15592-15594 IN denotes by
T9395 15595-15598 NN denotes Th1
T9396 15599-15604 NN denotes Cells
T9397 15605-15613 VB denotes Requires
T9398 15614-15618 NN denotes ERK1
T9399 15619-15622 CC denotes and
T9400 15623-15627 NN denotes ERK2
T9401 15628-15638 NN denotes Activation
T9402 15639-15642 PRP-DOLLAR- denotes Our
T9403 15643-15647 NN denotes data
T9404 15648-15654 VB denotes showed
T9405 15655-15659 IN denotes that
T9406 15660-15663 DT denotes the
T9407 15664-15675 NN denotes maintenance
T9408 15676-15678 IN denotes of
T9409 15679-15684 NN denotes IL-10
T9410 15685-15694 NN denotes induction
T9411 15695-15697 IN denotes in
T9412 15698-15701 NN denotes Th1
T9413 15702-15707 NN denotes cells
T9414 15708-15716 VB denotes required
T9415 15717-15728 NN denotes stimulation
T9416 15729-15733 IN denotes with
T9417 15734-15738 JJ denotes high
T9418 15739-15746 NN denotes antigen
T9419 15747-15751 NN denotes dose
T9420 15751-15752 -COMMA- denotes ,
T9421 15753-15758 WDT denotes which
T9422 15759-15761 TO denotes to
T9423 15762-15766 DT denotes some
T9424 15767-15773 NN denotes extent
T9425 15774-15779 MD denotes could
T9426 15780-15782 VB denotes be
T9427 15783-15794 VB denotes compensated
T9428 15795-15798 IN denotes for
T9429 15799-15801 IN denotes by
T9430 15802-15805 DT denotes the
T9431 15806-15814 NN denotes addition
T9432 15815-15817 IN denotes of
T9433 15818-15823 NN denotes IL-12
T9434 15825-15834 VB denotes Signaling
T9435 15835-15842 IN denotes through
T9436 15843-15846 DT denotes the
T9437 15847-15850 NN denotes TCR
T9438 15851-15855 IN denotes with
T9439 15856-15860 JJ denotes high
T9440 15861-15866 NN denotes doses
T9441 15867-15869 IN denotes of
T9442 15870-15877 NN denotes antigen
T9443 15878-15885 VB denotes induced
T9444 15886-15894 JJ denotes stronger
T9445 15895-15899 NN denotes ERK1
T9446 15900-15903 CC denotes and
T9447 15904-15908 NN denotes ERK2
T9448 15909-15919 NN denotes activation
T9449 15920-15924 IN denotes than
T9450 15925-15929 DT denotes that
T9451 15930-15937 VB denotes induced
T9452 15938-15940 IN denotes by
T9453 15941-15944 JJ denotes low
T9454 15945-15952 NN denotes antigen
T9455 15953-15957 NN denotes dose
T9456 15957-15958 -COMMA- denotes ,
T9457 15959-15962 RB denotes not
T9458 15963-15967 RB denotes only
T9459 15968-15970 IN denotes in
T9460 15971-15976 JJ denotes naive
T9461 15977-15981 JJ denotes CD4+
T9462 15982-15989 NN denotes T cells
T9463 15990-15991 -LRB- denotes (
T9464 15991-15995 NN denotes data
T9465 15996-15999 RB denotes not
T9466 16000-16005 VB denotes shown
T9467 16005-16006 -RRB- denotes )
T9468 16007-16009 IN denotes as
T9469 16010-16020 RB denotes previously
T9470 16021-16033 VB denotes demonstrated
T9471 16034-16035 -LRB- denotes (
T9472 16035-16044 NNP denotes Jorritsma
T9473 16045-16051 NNP denotes et al.
T9474 16051-16052 -COMMA- denotes ,
T9475 16053-16057 CD denotes 2003
T9476 16057-16058 -RRB- denotes )
T9477 16059-16062 CC denotes but
T9478 16063-16067 RB denotes also
T9479 16068-16070 IN denotes in
T9480 16071-16075 JJ denotes CD4+
T9481 16076-16083 NN denotes T cells
T9482 16084-16096 VB denotes restimulated
T9483 16097-16101 IN denotes with
T9484 16102-16105 DT denotes the
T9485 16106-16110 JJ denotes same
T9486 16111-16115 JJ denotes high
T9487 16116-16119 CC denotes and
T9488 16120-16123 JJ denotes low
T9489 16124-16131 NN denotes antigen
T9490 16132-16137 NN denotes doses
T9491 16138-16139 -LRB- denotes (
T9492 16139-16148 NN denotes Figure 5A
T9493 16148-16149 -RRB- denotes )
T9494 16151-16159 IN denotes Although
T9495 16160-16163 DT denotes the
T9496 16164-16172 JJ denotes apparent
T9497 16173-16177 NN denotes peak
T9498 16178-16181 CC denotes and
T9499 16182-16188 NN denotes amount
T9500 16189-16191 IN denotes of
T9501 16192-16196 NN denotes ERK1
T9502 16197-16200 CC denotes and
T9503 16201-16205 NN denotes ERK2
T9504 16206-16216 NN denotes activation
T9505 16217-16223 VB denotes varied
T9506 16224-16232 RB denotes slightly
T9507 16233-16240 IN denotes between
T9508 16241-16252 NN denotes experiments
T9509 16252-16253 -COMMA- denotes ,
T9510 16254-16255 DT denotes a
T9511 16256-16266 JJ denotes consistent
T9512 16267-16274 NN denotes finding
T9513 16275-16278 VB denotes was
T9514 16279-16283 IN denotes that
T9515 16284-16288 JJ denotes high
T9516 16289-16296 NN denotes antigen
T9517 16297-16301 NN denotes dose
T9518 16302-16316 VB denotes differentiated
T9519 16317-16320 NN denotes Th1
T9520 16321-16326 NN denotes cells
T9521 16327-16333 RB denotes always
T9522 16334-16340 VB denotes showed
T9523 16341-16349 VB denotes enhanced
T9524 16350-16353 CC denotes and
T9525 16354-16363 JJ denotes prolonged
T9526 16364-16368 NN denotes ERK1
T9527 16369-16372 CC denotes and
T9528 16373-16377 NN denotes ERK2
T9529 16378-16388 NN denotes activation
T9530 16389-16391 IN denotes in
T9531 16392-16395 DT denotes the
T9532 16396-16404 NN denotes presence
T9533 16405-16407 IN denotes of
T9534 16408-16413 NN denotes IL-12
T9535 16413-16414 -COMMA- denotes ,
T9536 16415-16425 RB denotes regardless
T9537 16426-16428 IN denotes of
T9538 16429-16436 IN denotes whether
T9539 16437-16441 PRP denotes they
T9540 16442-16446 VB denotes were
T9541 16447-16459 VB denotes restimulated
T9542 16460-16464 IN denotes with
T9543 16465-16469 JJ denotes high
T9544 16470-16472 CC denotes or
T9545 16473-16476 JJ denotes low
T9546 16477-16484 NN denotes antigen
T9547 16485-16489 NN denotes dose
T9548 16490-16491 -LRB- denotes (
T9549 16491-16500 NN denotes Figure 5B
T9550 16500-16501 -RRB- denotes )
T9551 16503-16505 PRP denotes We
T9552 16506-16510 RB denotes then
T9553 16511-16523 VB denotes investigated
T9554 16524-16531 IN denotes whether
T9555 16532-16536 NN denotes ERK1
T9556 16537-16540 CC denotes and
T9557 16541-16545 NN denotes ERK2
T9558 16546-16556 NN denotes activation
T9559 16557-16560 VB denotes was
T9560 16561-16569 VB denotes required
T9561 16570-16573 IN denotes for
T9562 16574-16577 DT denotes the
T9563 16578-16587 NN denotes induction
T9564 16588-16590 IN denotes of
T9565 16591-16596 NN denotes IL-10
T9566 16597-16599 IN denotes in
T9567 16600-16603 NN denotes Th1
T9568 16604-16609 NN denotes cells
T9569 16610-16612 IN denotes by
T9570 16613-16618 VB denotes using
T9571 16619-16624 NN denotes U0126
T9572 16625-16626 -LRB- denotes (
T9573 16626-16635 NN denotes Figure 5C
T9574 16635-16636 -RRB- denotes )
T9575 16636-16637 -COMMA- denotes ,
T9576 16638-16639 DT denotes a
T9577 16640-16648 NN denotes compound
T9578 16649-16653 WDT denotes that
T9579 16654-16660 VB denotes blocks
T9580 16661-16671 JJ denotes downstream
T9581 16672-16675 NN denotes ERK
T9582 16676-16686 NN denotes activation
T9583 16688-16690 TO denotes To
T9584 16691-16697 VB denotes ensure
T9585 16698-16702 IN denotes that
T9586 16703-16707 RB denotes only
T9587 16708-16714 NN denotes T cell
T9588 16715-16724 NN denotes signaling
T9589 16725-16728 VB denotes was
T9590 16729-16734 VB denotes being
T9591 16735-16743 VB denotes affected
T9592 16744-16746 IN denotes by
T9593 16747-16752 NN denotes U0126
T9594 16752-16753 -COMMA- denotes ,
T9595 16754-16756 PRP denotes we
T9596 16757-16761 VB denotes used
T9597 16762-16764 DT denotes an
T9598 16765-16773 JJ denotes APC-free
T9599 16774-16780 NN denotes system
T9600 16781-16783 IN denotes in
T9601 16784-16789 WDT denotes which
T9602 16790-16793 DT denotes the
T9603 16794-16801 NN denotes T cells
T9604 16802-16806 VB denotes were
T9605 16807-16821 VB denotes differentiated
T9606 16822-16824 IN denotes in
T9607 16825-16828 DT denotes the
T9608 16829-16837 NN denotes presence
T9609 16838-16840 IN denotes of
T9610 16841-16851 VB denotes increasing
T9611 16852-16857 NN denotes doses
T9612 16858-16860 IN denotes of
T9613 16861-16869 NN denotes anti-CD3
T9614 16870-16873 CC denotes and
T9615 16874-16875 DT denotes a
T9616 16876-16884 JJ denotes constant
T9617 16885-16891 NN denotes amount
T9618 16892-16894 IN denotes of
T9619 16895-16900 NN denotes IL-12
T9620 16902-16904 IN denotes As
T9621 16905-16907 IN denotes in
T9622 16908-16911 DT denotes the
T9623 16912-16922 JJ denotes APC-driven
T9624 16923-16931 NN denotes cultures
T9625 16931-16932 -COMMA- denotes ,
T9626 16933-16941 JJ denotes stronger
T9627 16942-16945 NN denotes TCR
T9628 16946-16957 NN denotes stimulation
T9629 16958-16966 RB denotes together
T9630 16967-16971 IN denotes with
T9631 16972-16977 NN denotes IL-12
T9632 16978-16981 VB denotes led
T9633 16982-16984 TO denotes to
T9634 16985-16991 JJ denotes higher
T9635 16992-17003 NN denotes percentages
T9636 17004-17006 IN denotes of
T9637 17007-17012 NN denotes cells
T9638 17013-17022 VB denotes producing
T9639 17023-17027 CC denotes both
T9640 17028-17033 NN denotes IL-10
T9641 17034-17037 CC denotes and
T9642 17038-17043 NN denotes IFN-γ
T9643 17044-17049 IN denotes after
T9644 17050-17051 CD denotes 1
T9645 17052-17056 NN denotes week
T9646 17057-17059 IN denotes of
T9647 17060-17067 NN denotes culture
T9648 17068-17069 -LRB- denotes (
T9649 17069-17078 NN denotes Figure 5C
T9650 17078-17079 -RRB- denotes )
T9651 17081-17089 NN denotes Addition
T9652 17090-17092 IN denotes of
T9653 17093-17098 NN denotes U0126
T9654 17099-17101 TO denotes to
T9655 17102-17105 DT denotes the
T9656 17106-17114 NN denotes cultures
T9657 17115-17124 VB denotes abrogated
T9658 17125-17128 DT denotes the
T9659 17129-17139 NN denotes production
T9660 17140-17142 IN denotes of
T9661 17143-17148 NN denotes IL-10
T9662 17149-17151 IN denotes at
T9663 17152-17155 DT denotes all
T9664 17156-17161 NN denotes doses
T9665 17162-17164 IN denotes of
T9666 17165-17173 NN denotes anti-CD3
T9667 17174-17175 -LRB- denotes (
T9668 17175-17184 NN denotes Figure 5C
T9669 17184-17185 -RRB- denotes )
T9670 17187-17194 IN denotes Because
T9671 17195-17200 NN denotes U0126
T9672 17201-17209 VB denotes inhibits
T9673 17210-17213 DT denotes the
T9674 17214-17228 JJ denotes MEK5-catalyzed
T9675 17229-17239 NN denotes activation
T9676 17240-17242 IN denotes of
T9677 17243-17247 NN denotes ERK5
T9678 17247-17248 -COMMA- denotes ,
T9679 17249-17251 RB denotes as
T9680 17252-17256 RB denotes well
T9681 17257-17259 IN denotes as
T9682 17260-17263 DT denotes the
T9683 17264-17269 NN denotes MEK1-
T9684 17270-17273 CC denotes and
T9685 17274-17288 JJ denotes MEK2-catalyzed
T9686 17289-17299 NN denotes activation
T9687 17300-17302 IN denotes of
T9688 17303-17307 NN denotes ERK1
T9689 17308-17311 CC denotes and
T9690 17312-17316 NN denotes ERK2
T9691 17317-17318 -LRB- denotes (
T9692 17318-17322 NNP denotes Bain
T9693 17323-17329 NNP denotes et al.
T9694 17329-17330 -COMMA- denotes ,
T9695 17331-17335 CD denotes 2007
T9696 17335-17336 -COLON- denotes ;
T9697 17337-17341 NNP denotes Mody
T9698 17342-17348 NNP denotes et al.
T9699 17348-17349 -COMMA- denotes ,
T9700 17350-17354 CD denotes 2001
T9701 17354-17355 -RRB- denotes )
T9702 17355-17356 -COMMA- denotes ,
T9703 17357-17359 PRP denotes we
T9704 17360-17364 RB denotes also
T9705 17365-17369 VB denotes used
T9706 17370-17373 DT denotes the
T9707 17374-17378 RB denotes more
T9708 17379-17387 JJ denotes specific
T9709 17387-17388 -COMMA- denotes ,
T9710 17389-17401 RB denotes structurally
T9711 17402-17411 JJ denotes unrelated
T9712 17412-17416 NN denotes MEK1
T9713 17417-17420 CC denotes and
T9714 17421-17425 NN denotes MEK2
T9715 17426-17435 NN denotes inhibitor
T9716 17436-17444 NN denotes PD184352
T9717 17445-17447 IN denotes at
T9718 17448-17462 NN denotes concentrations
T9719 17463-17465 IN denotes in
T9720 17466-17471 WDT denotes which
T9721 17472-17474 PRP denotes it
T9722 17475-17483 VB denotes inhibits
T9723 17484-17488 NN denotes MEK1
T9724 17489-17492 CC denotes and
T9725 17493-17497 NN denotes MEK2
T9726 17498-17501 CC denotes but
T9727 17502-17505 RB denotes not
T9728 17506-17510 NN denotes MEK5
T9729 17511-17512 -LRB- denotes (
T9730 17512-17516 NNP denotes Bain
T9731 17517-17523 NNP denotes et al.
T9732 17523-17524 -COMMA- denotes ,
T9733 17525-17529 CD denotes 2007
T9734 17529-17530 -COLON- denotes ;
T9735 17531-17535 NNP denotes Mody
T9736 17536-17542 NNP denotes et al.
T9737 17542-17543 -COMMA- denotes ,
T9738 17544-17548 CD denotes 2001
T9739 17548-17549 -RRB- denotes )
T9740 17551-17559 NN denotes PD184352
T9741 17560-17566 VB denotes caused
T9742 17567-17568 DT denotes a
T9743 17569-17576 JJ denotes similar
T9744 17577-17587 NN denotes inhibition
T9745 17588-17590 IN denotes of
T9746 17591-17596 NN denotes IL-10
T9747 17597-17607 NN denotes production
T9748 17608-17610 IN denotes by
T9749 17611-17614 NN denotes Th1
T9750 17615-17620 NN denotes cells
T9751 17621-17623 IN denotes in
T9752 17624-17625 DT denotes a
T9753 17626-17640 JJ denotes dose-dependent
T9754 17641-17648 NN denotes fashion
T9755 17649-17650 -LRB- denotes (
T9756 17650-17659 NN denotes Figure 5D
T9757 17660-17663 CC denotes and
T9758 17664-17674 NN denotes Figure S5A
T9759 17674-17675 -RRB- denotes )
T9760 17677-17681 IN denotes Upon
T9761 17682-17690 NN denotes addition
T9762 17691-17693 IN denotes of
T9763 17694-17704 NN denotes inhibitors
T9764 17705-17707 TO denotes to
T9765 17708-17723 NN denotes other signaling
T9766 17724-17732 NN denotes pathways
T9767 17732-17733 -COMMA- denotes ,
T9768 17734-17743 VB denotes including
T9769 17744-17745 DT denotes a
T9770 17746-17749 NN denotes p38
T9771 17750-17754 NN denotes MAPK
T9772 17755-17764 NN denotes inhibitor
T9773 17764-17765 -COMMA- denotes ,
T9774 17766-17774 NN denotes SB203580
T9775 17774-17775 -COMMA- denotes ,
T9776 17776-17778 CC denotes or
T9777 17779-17782 DT denotes the
T9778 17783-17788 NN denotes GSK3β
T9779 17789-17798 NN denotes inhibitor
T9780 17798-17799 -COMMA- denotes ,
T9781 17800-17807 NN denotes CT99021
T9782 17808-17809 -LRB- denotes (
T9783 17809-17813 NNP denotes Bain
T9784 17814-17820 NNP denotes et al.
T9785 17820-17821 -COMMA- denotes ,
T9786 17822-17826 CD denotes 2007
T9787 17826-17827 -RRB- denotes )
T9788 17827-17828 -COMMA- denotes ,
T9789 17829-17831 DT denotes no
T9790 17832-17838 NN denotes effect
T9791 17839-17841 IN denotes on
T9792 17842-17847 NN denotes IL-10
T9793 17848-17858 NN denotes production
T9794 17859-17862 VB denotes was
T9795 17863-17871 VB denotes observed
T9796 17872-17873 -LRB- denotes (
T9797 17873-17883 NN denotes Figure S5B
T9798 17883-17884 -RRB- denotes )
T9799 17886-17889 PRP-DOLLAR- denotes Our
T9800 17890-17894 NN denotes data
T9801 17895-17899 RB denotes thus
T9802 17900-17909 VB denotes suggested
T9803 17910-17914 IN denotes that
T9804 17915-17920 NN denotes IL-10
T9805 17921-17931 NN denotes production
T9806 17932-17934 IN denotes by
T9807 17935-17938 NN denotes Th1
T9808 17939-17944 NN denotes cells
T9809 17945-17947 IN denotes in
T9810 17948-17956 NN denotes response
T9811 17957-17959 TO denotes to
T9812 17960-17964 JJ denotes high
T9813 17965-17972 NN denotes antigen
T9814 17973-17977 NN denotes dose
T9815 17978-17981 CC denotes and
T9816 17982-17987 NN denotes IL-12
T9817 17988-17996 VB denotes requires
T9818 17997-18001 NN denotes ERK1
T9819 18002-18005 CC denotes and
T9820 18006-18010 NN denotes ERK2
T9821 18011-18020 NN denotes signaling
T9822 18020-18021 -COMMA- denotes ,
T9823 18022-18025 CC denotes but
T9824 18026-18029 RB denotes not
T9825 18030-18033 DT denotes the
T9826 18034-18044 NN denotes activation
T9827 18045-18047 IN denotes of
T9828 18048-18051 DT denotes the
T9829 18052-18055 NN denotes p38
T9830 18056-18058 CC denotes or
T9831 18059-18062 DT denotes the
T9832 18063-18068 NN denotes GSK3β
T9833 18069-18077 NN denotes pathways
T11027 18080-18085 NN denotes IL-10
T11028 18086-18096 NN denotes Production
T11029 18097-18099 IN denotes by
T11030 18100-18103 NN denotes Th2
T11031 18104-18107 CC denotes and
T11032 18108-18112 NN denotes Th17
T11033 18113-18118 NN denotes Cells
T11034 18119-18123 RB denotes Also
T11035 18124-18132 VB denotes Requires
T11036 18133-18137 NN denotes ERK1
T11037 18138-18141 CC denotes and
T11038 18142-18146 NN denotes ERK2
T11039 18147-18157 NN denotes Activation
T11040 18158-18160 TO denotes To
T11041 18161-18168 VB denotes address
T11042 18169-18176 IN denotes whether
T11043 18177-18182 NN denotes IL-10
T11044 18183-18193 NN denotes production
T11045 18194-18196 IN denotes by
T11046 18197-18200 NN denotes Th2
T11047 18201-18204 CC denotes and
T11048 18205-18209 NN denotes Th17
T11049 18210-18215 NN denotes cells
T11050 18216-18219 VB denotes was
T11051 18220-18224 RB denotes also
T11052 18225-18234 JJ denotes dependent
T11053 18235-18237 IN denotes on
T11054 18238-18242 NN denotes ERK1
T11055 18243-18246 CC denotes and
T11056 18247-18251 NN denotes ERK2
T11057 18252-18262 NN denotes activation
T11058 18262-18263 -COMMA- denotes ,
T11059 18264-18266 PRP denotes we
T11060 18267-18281 VB denotes differentiated
T11061 18282-18287 DT denotes these
T11062 18288-18293 NN denotes cells
T11063 18294-18298 IN denotes with
T11064 18299-18307 JJ denotes anti-CD3
T11065 18308-18311 CC denotes and
T11066 18312-18321 JJ denotes anti-CD28
T11067 18322-18324 IN denotes in
T11068 18325-18328 DT denotes the
T11069 18329-18336 NN denotes absence
T11070 18337-18339 IN denotes of
T11071 18340-18344 NN denotes APCs
T11072 18345-18346 -LRB- denotes (
T11073 18346-18355 NN denotes Shoemaker
T11074 18356-18362 NNP denotes et al.
T11075 18362-18363 -COMMA- denotes ,
T11076 18364-18368 CD denotes 2006
T11077 18368-18369 -COLON- denotes ;
T11078 18370-18378 NNP denotes Veldhoen
T11079 18379-18385 FW denotes et al.
T11080 18385-18386 -COMMA- denotes ,
T11081 18387-18391 CD denotes 2009
T11082 18391-18392 -COLON- denotes ;
T11083 18393-18401 NNP denotes Veldhoen
T11084 18402-18408 FW denotes et al.
T11085 18408-18409 -COMMA- denotes ,
T11086 18410-18414 CD denotes 2006
T11087 18414-18415 -RRB- denotes )
T11088 18415-18416 -COMMA- denotes ,
T11089 18417-18419 IN denotes in
T11090 18420-18423 DT denotes the
T11091 18424-18432 NN denotes presence
T11092 18433-18435 CC denotes or
T11093 18436-18443 NN denotes absence
T11094 18444-18446 IN denotes of
T11095 18447-18450 DT denotes the
T11096 18451-18454 NN denotes MEK
T11097 18455-18464 NN denotes inhibitor
T11098 18465-18466 -LRB- denotes (
T11099 18466-18474 NN denotes PD184352
T11100 18474-18475 -RRB- denotes )
T11101 18477-18479 PRP denotes We
T11102 18480-18486 VB denotes showed
T11103 18487-18491 IN denotes that
T11104 18492-18496 NN denotes ERK1
T11105 18497-18500 CC denotes and
T11106 18501-18505 NN denotes ERK2
T11107 18506-18516 NN denotes activation
T11108 18517-18519 VB denotes is
T11109 18520-18521 DT denotes a
T11110 18522-18528 JJ denotes common
T11111 18529-18536 NN denotes pathway
T11112 18537-18545 VB denotes required
T11113 18546-18549 IN denotes for
T11114 18550-18559 NN denotes induction
T11115 18560-18562 IN denotes of
T11116 18563-18568 NN denotes IL-10
T11117 18569-18571 IN denotes in
T11118 18572-18581 JJ denotes different
T11119 18582-18584 NN denotes Th
T11120 18585-18589 NN denotes cell
T11121 18590-18597 NN denotes subsets
T11122 18598-18605 IN denotes because
T11123 18606-18611 NN denotes IL-10
T11124 18612-18622 NN denotes production
T11125 18623-18625 IN denotes by
T11126 18626-18630 CC denotes both
T11127 18631-18634 NN denotes Th2
T11128 18635-18638 CC denotes and
T11129 18639-18643 NN denotes Th17
T11130 18644-18649 NN denotes cells
T11131 18650-18653 VB denotes was
T11132 18654-18662 RB denotes markedly
T11133 18663-18672 VB denotes inhibited
T11134 18673-18675 IN denotes in
T11135 18676-18679 DT denotes the
T11136 18680-18688 NN denotes presence
T11137 18689-18691 IN denotes of
T11138 18692-18695 DT denotes the
T11139 18696-18699 NN denotes MEK
T11140 18700-18709 NN denotes inhibitor
T11141 18710-18711 -LRB- denotes (
T11142 18711-18719 NN denotes PD184352
T11143 18719-18720 -RRB- denotes )
T11144 18721-18722 -LRB- denotes (
T11145 18722-18731 NN denotes Figure 5D
T11146 18732-18735 CC denotes and
T11147 18736-18746 NN denotes Figure S5B
T11148 18746-18747 -RRB- denotes )
T11149 18749-18751 IN denotes In
T11150 18752-18760 NN denotes contrast
T11151 18760-18761 -COMMA- denotes ,
T11152 18762-18772 NN denotes inhibitors
T11153 18773-18775 IN denotes of
T11154 18776-18779 NN denotes p38
T11155 18780-18784 NN denotes MAPK
T11156 18785-18787 CC denotes or
T11157 18788-18790 IN denotes of
T11158 18791-18797 NN denotes GSK-3β
T11159 18798-18808 NN denotes activation
T11160 18809-18812 VB denotes did
T11161 18813-18816 RB denotes not
T11162 18817-18823 VB denotes affect
T11163 18824-18827 DT denotes the
T11164 18828-18838 NN denotes expression
T11165 18839-18841 IN denotes of
T11166 18842-18847 NN denotes IL-10
T11167 18848-18850 IN denotes by
T11168 18851-18856 DT denotes these
T11169 18857-18864 NN denotes subsets
T11170 18865-18866 -LRB- denotes (
T11171 18866-18876 NN denotes Figure S5B
T11172 18876-18877 -RRB- denotes )
T11173 18879-18889 NN denotes Activation
T11174 18890-18892 IN denotes of
T11175 18893-18896 DT denotes the
T11176 18897-18901 NN denotes ERK1
T11177 18902-18905 CC denotes and
T11178 18906-18910 NN denotes ERK2
T11179 18911-18920 NN denotes signaling
T11180 18921-18928 NN denotes pathway
T11181 18929-18931 VB denotes is
T11182 18932-18941 RB denotes therefore
T11183 18942-18943 DT denotes a
T11184 18944-18950 JJ denotes common
T11185 18951-18962 NN denotes requirement
T11186 18963-18966 IN denotes for
T11187 18967-18970 DT denotes the
T11188 18971-18980 NN denotes induction
T11189 18981-18983 IN denotes of
T11190 18984-18989 NN denotes IL-10
T11191 18990-19000 NN denotes production
T11192 19001-19003 IN denotes by
T11193 19004-19007 NN denotes Th1
T11194 19007-19008 -COMMA- denotes ,
T11195 19009-19012 NN denotes Th2
T11196 19012-19013 -COMMA- denotes ,
T11197 19014-19017 CC denotes and
T11198 19018-19022 NN denotes Th17
T11199 19023-19028 NN denotes cells
T11958 19031-19036 NN denotes c-maf
T11959 19037-19047 NN denotes Expression
T11960 19048-19058 VB denotes Correlates
T11961 19059-19063 IN denotes with
T11962 19064-19069 NN denotes IL-10
T11963 19070-19080 NN denotes Production
T11964 19081-19083 IN denotes in
T11965 19084-19087 NN denotes Th1
T11966 19087-19088 -COMMA- denotes ,
T11967 19089-19092 NN denotes Th2
T11968 19092-19093 -COMMA- denotes ,
T11969 19094-19097 CC denotes and
T11970 19098-19102 NN denotes Th17
T11971 19103-19108 NN denotes Cells
T11972 19109-19111 TO denotes To
T11973 19112-19123 VB denotes investigate
T11974 19124-19131 RB denotes further
T11975 19132-19135 DT denotes the
T11976 19136-19146 JJ denotes downstream
T11977 19147-19154 NN denotes factors
T11978 19155-19163 VB denotes involved
T11979 19164-19166 IN denotes in
T11980 19167-19177 VB denotes regulating
T11981 19178-19183 NN denotes IL-10
T11982 19184-19194 NN denotes production
T11983 19194-19195 -COMMA- denotes ,
T11984 19196-19198 PRP denotes we
T11985 19199-19213 VB denotes differentiated
T11986 19214-19221 NN denotes DO11.10
T11987 19222-19226 JJ denotes CD4+
T11988 19227-19234 NN denotes T cells
T11989 19235-19239 IN denotes with
T11990 19240-19250 VB denotes increasing
T11991 19251-19256 NN denotes doses
T11992 19257-19259 IN denotes of
T11993 19260-19263 NN denotes OVA
T11994 19263-19264 -COMMA- denotes ,
T11995 19265-19267 IN denotes in
T11996 19268-19271 DT denotes the
T11997 19272-19280 NN denotes presence
T11998 19281-19283 CC denotes or
T11999 19284-19291 NN denotes absence
T12000 19292-19294 IN denotes of
T12001 19295-19300 NN denotes IL-12
T12002 19300-19301 -COMMA- denotes ,
T12003 19302-19305 CC denotes and
T12004 19306-19316 VB denotes quantified
T12005 19317-19320 DT denotes the
T12006 19321-19331 NN denotes expression
T12007 19332-19334 IN denotes of
T12008 19335-19344 NN denotes cytokines
T12009 19345-19348 CC denotes and
T12010 19349-19362 NN denotes transcription
T12011 19363-19370 NN denotes factors
T12012 19371-19373 IN denotes by
T12013 19374-19383 JJ denotes real-time
T12014 19384-19390 NN denotes RT-PCR
T12015 19392-19400 JJ denotes Low-dose
T12016 19401-19408 NN denotes antigen
T12017 19409-19417 VB denotes resulted
T12018 19418-19420 IN denotes in
T12019 19421-19434 NN denotes transcription
T12020 19435-19437 IN denotes of
T12021 19438-19441 NN denotes Il4
T12022 19442-19445 CC denotes and
T12023 19446-19450 DT denotes this
T12024 19451-19454 VB denotes was
T12025 19455-19464 VB denotes abrogated
T12026 19465-19467 IN denotes by
T12027 19468-19472 CC denotes both
T12028 19473-19477 JJ denotes high
T12029 19478-19485 NN denotes antigen
T12030 19486-19491 NN denotes doses
T12031 19492-19495 CC denotes and
T12032 19496-19501 NN denotes IL-12
T12033 19502-19503 -LRB- denotes (
T12034 19503-19512 NN denotes Figure 6A
T12035 19512-19513 -RRB- denotes )
T12036 19515-19516 DT denotes A
T12037 19517-19520 JJ denotes low
T12038 19521-19527 NN denotes amount
T12039 19528-19530 IN denotes of
T12040 19531-19544 NN denotes transcription
T12041 19545-19547 IN denotes of
T12042 19548-19552 NN denotes Ifnγ
T12043 19553-19556 VB denotes was
T12044 19557-19564 VB denotes induced
T12045 19565-19567 IN denotes by
T12046 19568-19573 NN denotes IL-12
T12047 19574-19578 WRB denotes when
T12048 19579-19584 NN denotes cells
T12049 19585-19589 VB denotes were
T12050 19590-19604 VB denotes differentiated
T12051 19605-19609 IN denotes with
T12052 19610-19613 JJ denotes low
T12053 19614-19621 NN denotes antigen
T12054 19622-19626 NN denotes dose
T12055 19626-19627 -COMMA- denotes ,
T12056 19628-19631 CC denotes but
T12057 19632-19636 DT denotes this
T12058 19637-19643 NN denotes effect
T12059 19644-19646 IN denotes of
T12060 19647-19652 NN denotes IL-12
T12061 19653-19656 VB denotes was
T12062 19657-19665 RB denotes markedly
T12063 19666-19677 VB denotes upregulated
T12064 19678-19682 IN denotes with
T12065 19683-19693 VB denotes increasing
T12066 19694-19699 NN denotes doses
T12067 19700-19702 IN denotes of
T12068 19703-19710 NN denotes antigen
T12069 19711-19712 -LRB- denotes (
T12070 19712-19721 NN denotes Figure 6A
T12071 19721-19722 -RRB- denotes )
T12072 19724-19725 DT denotes A
T12073 19726-19729 JJ denotes low
T12074 19730-19736 NN denotes amount
T12075 19737-19739 IN denotes of
T12076 19740-19744 NN denotes Il10
T12077 19745-19758 NN denotes transcription
T12078 19759-19762 VB denotes was
T12079 19763-19771 VB denotes observed
T12080 19772-19774 IN denotes at
T12081 19775-19778 JJ denotes low
T12082 19779-19784 NN denotes doses
T12083 19785-19787 IN denotes of
T12084 19788-19795 NN denotes antigen
T12085 19796-19808 VB denotes accompanying
T12086 19809-19812 NN denotes Il4
T12087 19813-19823 NN denotes expression
T12088 19824-19825 -LRB- denotes (
T12089 19825-19828 NN denotes Th2
T12090 19829-19833 NN denotes cell
T12091 19834-19842 NN denotes response
T12092 19842-19843 -RRB- denotes )
T12093 19843-19844 -COMMA- denotes ,
T12094 19845-19848 CC denotes and
T12095 19849-19853 DT denotes this
T12096 19854-19857 VB denotes was
T12097 19858-19867 VB denotes abrogated
T12098 19868-19870 IN denotes by
T12099 19871-19880 VB denotes increased
T12100 19881-19886 NN denotes doses
T12101 19887-19889 IN denotes of
T12102 19890-19897 NN denotes antigen
T12103 19898-19900 IN denotes as
T12104 19901-19904 VB denotes was
T12105 19905-19908 NN denotes Il4
T12106 19909-19919 NN denotes expression
T12107 19920-19921 -LRB- denotes (
T12108 19921-19930 NN denotes Figure 6A
T12109 19930-19931 -RRB- denotes )
T12110 19933-19935 IN denotes At
T12111 19936-19939 JJ denotes low
T12112 19940-19945 NN denotes doses
T12113 19946-19948 IN denotes of
T12114 19949-19956 NN denotes antigen
T12115 19956-19957 -COMMA- denotes ,
T12116 19958-19963 NN denotes IL-12
T12117 19964-19967 VB denotes had
T12118 19968-19974 JJ denotes little
T12119 19975-19981 NN denotes effect
T12120 19982-19984 TO denotes to
T12121 19985-19993 VB denotes increase
T12122 19994-19999 NN denotes IL-10
T12123 20000-20004 NN denotes mRNA
T12124 20005-20015 NN denotes expression
T12125 20016-20017 -LRB- denotes (
T12126 20017-20026 NN denotes Figure 6A
T12127 20026-20027 -RRB- denotes )
T12128 20028-20030 IN denotes in
T12129 20031-20038 VB denotes keeping
T12130 20039-20043 IN denotes with
T12131 20044-20047 DT denotes the
T12132 20048-20055 NN denotes protein
T12133 20056-20060 NN denotes data
T12134 20061-20062 -LRB- denotes (
T12135 20062-20071 NN denotes Figure 1A
T12136 20071-20072 -RRB- denotes )
T12137 20074-20081 RB denotes However
T12138 20081-20082 -COMMA- denotes ,
T12139 20083-20088 NN denotes IL-12
T12140 20089-20096 VB denotes induced
T12141 20097-20098 DT denotes a
T12142 20099-20103 JJ denotes high
T12143 20104-20110 NN denotes amount
T12144 20111-20113 IN denotes of
T12145 20114-20118 NN denotes Il10
T12146 20119-20132 NN denotes transcription
T12147 20133-20135 RB denotes as
T12148 20136-20140 RB denotes well
T12149 20141-20143 IN denotes as
T12150 20144-20148 NN denotes Ifnγ
T12151 20149-20159 NN denotes expression
T12152 20160-20164 IN denotes with
T12153 20165-20174 VB denotes increased
T12154 20175-20182 NN denotes antigen
T12155 20183-20188 NN denotes doses
T12156 20189-20190 -LRB- denotes (
T12157 20190-20199 NN denotes Figure 6A
T12158 20199-20200 -RRB- denotes )
T12159 20200-20201 -COMMA- denotes ,
T12160 20202-20207 RB denotes again
T12161 20208-20210 IN denotes in
T12162 20211-20218 VB denotes keeping
T12163 20219-20223 IN denotes with
T12164 20224-20227 DT denotes the
T12165 20228-20235 NN denotes protein
T12166 20236-20240 NN denotes data
T12167 20241-20242 -LRB- denotes (
T12168 20242-20251 NN denotes Figure 1A
T12169 20251-20252 -RRB- denotes )
T12170 20254-20258 JJ denotes CD4+
T12171 20259-20266 NN denotes T cells
T12172 20267-20281 VB denotes differentiated
T12173 20282-20286 IN denotes with
T12174 20287-20297 VB denotes increasing
T12175 20298-20303 NN denotes doses
T12176 20304-20306 IN denotes of
T12177 20307-20314 NN denotes antigen
T12178 20315-20318 VB denotes did
T12179 20319-20322 RB denotes not
T12180 20323-20330 VB denotes express
T12181 20331-20335 JJ denotes high
T12182 20336-20343 NN denotes amounts
T12183 20344-20346 IN denotes of
T12184 20347-20353 NN denotes Tbx-21
T12185 20354-20355 -LRB- denotes (
T12186 20355-20360 NN denotes T-bet
T12187 20360-20361 -RRB- denotes )
T12188 20362-20366 NN denotes mRNA
T12189 20366-20367 -COMMA- denotes ,
T12190 20368-20374 IN denotes unless
T12191 20375-20379 PRP denotes they
T12192 20380-20384 VB denotes were
T12193 20385-20395 VB denotes cocultured
T12194 20396-20400 IN denotes with
T12195 20401-20406 NN denotes IL-12
T12196 20407-20408 -LRB- denotes (
T12197 20408-20417 NN denotes Figure 6B
T12198 20417-20418 -RRB- denotes )
T12199 20420-20422 IN denotes In
T12200 20423-20431 NN denotes contrast
T12201 20431-20432 -COMMA- denotes ,
T12202 20433-20437 JJ denotes high
T12203 20438-20445 NN denotes amounts
T12204 20446-20448 IN denotes of
T12205 20449-20455 NN denotes GATA-3
T12206 20456-20460 NN denotes mRNA
T12207 20461-20471 NN denotes expression
T12208 20472-20476 VB denotes were
T12209 20477-20481 RB denotes only
T12210 20482-20490 VB denotes observed
T12211 20491-20496 IN denotes under
T12212 20497-20500 NN denotes Th2
T12213 20501-20505 NN denotes cell
T12214 20506-20521 NN denotes differentiation
T12215 20522-20532 NN denotes conditions
T12216 20533-20534 -LRB- denotes (
T12217 20534-20542 JJ denotes low-dose
T12218 20543-20550 NN denotes antigen
T12219 20550-20551 -RRB- denotes )
T12220 20552-20553 -LRB- denotes (
T12221 20553-20562 NN denotes Figure 6B
T12222 20562-20563 -RRB- denotes )
T12223 20563-20564 -COMMA- denotes ,
T12224 20565-20568 CC denotes and
T12225 20569-20573 DT denotes this
T12226 20574-20584 NN denotes expression
T12227 20585-20588 VB denotes was
T12228 20589-20597 RB denotes markedly
T12229 20598-20611 VB denotes downregulated
T12230 20612-20614 IN denotes by
T12231 20615-20619 CC denotes both
T12232 20620-20630 VB denotes increasing
T12233 20631-20638 NN denotes antigen
T12234 20639-20643 NN denotes dose
T12235 20644-20647 CC denotes and
T12236 20648-20657 NN denotes coculture
T12237 20658-20660 IN denotes in
T12238 20661-20666 NN denotes IL-12
T12239 20667-20668 -LRB- denotes (
T12240 20668-20677 NN denotes Figure 6B
T12241 20677-20678 -RRB- denotes )
T12242 20680-20695 NN denotes Differentiation
T12243 20696-20698 IN denotes of
T12244 20699-20706 NN denotes T cells
T12245 20707-20712 IN denotes under
T12246 20713-20716 JJ denotes low
T12247 20717-20724 NN denotes antigen
T12248 20725-20729 NN denotes dose
T12249 20730-20733 VB denotes led
T12250 20734-20736 TO denotes to
T12251 20737-20747 NN denotes expression
T12252 20748-20750 IN denotes of
T12253 20751-20756 NN denotes c-maf
T12254 20756-20757 -COMMA- denotes ,
T12255 20758-20760 IN denotes in
T12256 20761-20768 VB denotes keeping
T12257 20769-20773 IN denotes with
T12258 20774-20777 DT denotes the
T12259 20778-20781 NN denotes Th2
T12260 20782-20786 NN denotes cell
T12261 20787-20794 NN denotes profile
T12262 20795-20796 -LRB- denotes (
T12263 20796-20798 NNP denotes Ho
T12264 20799-20805 NNP denotes et al.
T12265 20805-20806 -COMMA- denotes ,
T12266 20807-20811 CD denotes 1996
T12267 20811-20812 -RRB- denotes )
T12268 20812-20813 -COMMA- denotes ,
T12269 20814-20819 WDT denotes which
T12270 20820-20823 VB denotes was
T12271 20824-20830 RB denotes almost
T12272 20831-20841 RB denotes completely
T12273 20842-20851 VB denotes abrogated
T12274 20852-20854 IN denotes by
T12275 20855-20865 VB denotes increasing
T12276 20866-20871 NN denotes doses
T12277 20872-20874 IN denotes of
T12278 20875-20882 NN denotes antigen
T12279 20883-20884 -LRB- denotes (
T12280 20884-20893 NN denotes Figure 6B
T12281 20893-20894 -RRB- denotes )
T12282 20896-20909 RB denotes Interestingly
T12283 20909-20910 -COMMA- denotes ,
T12284 20911-20916 NN denotes IL-12
T12285 20917-20926 VB denotes sustained
T12286 20927-20930 DT denotes the
T12287 20931-20935 JJ denotes high
T12288 20936-20946 NN denotes expression
T12289 20947-20949 IN denotes of
T12290 20950-20955 NN denotes c-Maf
T12291 20956-20960 NN denotes mRNA
T12292 20961-20965 RB denotes even
T12293 20966-20968 IN denotes at
T12294 20969-20972 DT denotes the
T12295 20973-20980 JJ denotes highest
T12296 20981-20988 NN denotes antigen
T12297 20989-20993 NN denotes dose
T12298 20994-20995 -LRB- denotes (
T12299 20995-21004 NN denotes Figure 6B
T12300 21004-21005 -RRB- denotes )
T12301 21007-21015 RB denotes Moreover
T12302 21015-21016 -COMMA- denotes ,
T12303 21017-21022 NN denotes IL-12
T12304 21023-21034 NN denotes maintenance
T12305 21035-21037 IN denotes of
T12306 21038-21043 NN denotes c-maf
T12307 21044-21054 NN denotes expression
T12308 21055-21063 VB denotes required
T12309 21064-21069 NN denotes STAT4
T12310 21070-21080 NN denotes activation
T12311 21081-21082 -LRB- denotes (
T12312 21082-21086 NN denotes data
T12313 21087-21090 RB denotes not
T12314 21091-21096 VB denotes shown
T12315 21096-21097 -RRB- denotes )
T12316 21099-21101 IN denotes In
T12317 21102-21106 NN denotes Th17
T12318 21107-21112 NN denotes cells
T12319 21113-21117 WDT denotes that
T12320 21118-21127 VB denotes expressed
T12321 21128-21134 NN denotes IL-17a
T12322 21135-21137 RB denotes as
T12323 21138-21142 RB denotes well
T12324 21143-21145 IN denotes as
T12325 21146-21151 NN denotes IL-10
T12326 21152-21156 NN denotes mRNA
T12327 21157-21158 -LRB- denotes (
T12328 21158-21167 NN denotes Figure 6C
T12329 21167-21168 -RRB- denotes )
T12330 21168-21169 -COMMA- denotes ,
T12331 21170-21175 NN denotes T-bet
T12332 21176-21179 CC denotes and
T12333 21180-21186 NN denotes GATA-3
T12334 21187-21191 NN denotes mRNA
T12335 21192-21196 VB denotes were
T12336 21197-21209 JJ denotes undetectable
T12337 21210-21211 -LRB- denotes (
T12338 21211-21215 NN denotes data
T12339 21216-21219 RB denotes not
T12340 21220-21225 VB denotes shown
T12341 21225-21226 -RRB- denotes )
T12342 21226-21227 -COMMA- denotes ,
T12343 21228-21235 IN denotes whereas
T12344 21236-21240 DT denotes that
T12345 21241-21243 IN denotes of
T12346 21244-21250 NN denotes ROR-γt
T12347 21251-21254 VB denotes was
T12348 21255-21259 JJ denotes high
T12349 21260-21261 -LRB- denotes (
T12350 21261-21270 NN denotes Figure 6C
T12351 21270-21271 -RRB- denotes )
T12352 21272-21273 -LRB- denotes (
T12353 21273-21279 NNP denotes Ivanov
T12354 21280-21286 NNP denotes et al.
T12355 21286-21287 -COMMA- denotes ,
T12356 21288-21292 CD denotes 2007
T12357 21292-21293 -RRB- denotes )
T12358 21295-21299 NN denotes Th17
T12359 21300-21305 NN denotes cells
T12360 21306-21310 RB denotes also
T12361 21311-21320 VB denotes expressed
T12362 21321-21325 JJ denotes high
T12363 21326-21333 NN denotes amounts
T12364 21334-21336 IN denotes of
T12365 21337-21342 NN denotes c-maf
T12366 21343-21344 -LRB- denotes (
T12367 21344-21353 NN denotes Figure 6C
T12368 21353-21354 -RRB- denotes )
T12369 21354-21355 -COMMA- denotes ,
T12370 21356-21366 VB denotes confirming
T12371 21367-21368 DT denotes a
T12372 21369-21375 JJ denotes recent
T12373 21376-21382 NN denotes report
T12374 21383-21384 -LRB- denotes (
T12375 21384-21391 NNP denotes Bauquet
T12376 21392-21398 NNP denotes et al.
T12377 21398-21399 -COMMA- denotes ,
T12378 21400-21404 CD denotes 2009
T12379 21404-21405 -RRB- denotes )
T12380 21405-21410 NN denotes . c-M
T12381 21410-21412 VB denotes af
T12382 21413-21422 RB denotes is theref
T12383 21422-21431 VB denotes ore expre
T12384 21431-21433 IN denotes ss
T12385 21433-21436 DT denotes ed
T12386 21436-21452 JJ denotes in all IL-10-exp
T12387 21452-21458 NN denotes ressin
T12388 21458-21469 NN denotes g T cell po
T12389 21469-21475 VB denotes pulati
T12390 21475-21476 -LRB- denotes o
T12391 21476-21483 NN denotes ns test
T12392 21483-21485 NN denotes ed
T12393 21486-21489 CC denotes (Fi
T12394 21489-21491 NN denotes gu
T12395 21491-21492 -RRB- denotes r
T12396 21492-21495 CC denotes es
T12397 21495-21498 MD denotes 6B
T12398 21498-21501 RB denotes and
T12399 21502-21504 VB denotes 6C
T12400 21504-21508 RB denotes ) an
T12401 21508-21509 DT denotes d
T12402 21510-21513 NN denotes may
T12403 21514-21527 JJ denotes not be just a
T12404 21528-21541 NN denotes Th2 cell-spec
T12405 21541-21547 NN denotes ific t
T12406 21547-21549 IN denotes ra
T12407 21549-21559 RB denotes nscription
T12408 21560-21567 VB denotes factor
T12409 21567-21568 -LRB- denotes a
T12410 21568-21570 NNP denotes s
T12411 21570-21576 NNP denotes origin
T12412 21576-21577 -COMMA- denotes a
T12413 21577-21581 CD denotes lly
T12414 21581-21582 -RRB- denotes t
T12415 21608-21610 PRP denotes We
T12416 21611-21617 VB denotes showed
T12417 21618-21622 RB denotes also
T12418 21623-21627 IN denotes that
T12419 21628-21632 IN denotes like
T12420 21633-21637 NN denotes Il10
T12421 21638-21648 NN denotes expression
T12422 21648-21649 -COMMA- denotes ,
T12423 21650-21655 NN denotes c-maf
T12424 21656-21666 NN denotes expression
T12425 21667-21670 VB denotes was
T12426 21671-21680 VB denotes inhibited
T12427 21681-21683 IN denotes in
T12428 21684-21687 NN denotes Th1
T12429 21688-21691 CC denotes and
T12430 21692-21696 NN denotes Th17
T12431 21697-21702 NN denotes cells
T12432 21703-21705 IN denotes in
T12433 21706-21709 DT denotes the
T12434 21710-21718 NN denotes presence
T12435 21719-21721 IN denotes of
T12436 21722-21725 DT denotes the
T12437 21726-21730 NN denotes MEK1
T12438 21731-21734 CC denotes and
T12439 21735-21739 NN denotes MEK2
T12440 21740-21749 NN denotes inhibitor
T12441 21750-21751 -LRB- denotes (
T12442 21751-21759 NN denotes PD184352
T12443 21759-21760 -RRB- denotes )
T12444 21760-21761 -COMMA- denotes ,
T12445 21762-21769 IN denotes whereas
T12446 21770-21775 NN denotes T-bet
T12447 21776-21779 CC denotes and
T12448 21780-21785 NN denotes RORγt
T12449 21786-21796 NN denotes expression
T12450 21797-21800 VB denotes was
T12451 21801-21807 RB denotes hardly
T12452 21808-21816 VB denotes affected
T12453 21817-21818 -LRB- denotes (
T12454 21818-21827 NN denotes Figure 6D
T12455 21827-21828 -RRB- denotes )
T14233 21842-21847 NN denotes IL-10
T14234 21848-21858 NN denotes expression
T14235 21859-21861 IN denotes by
T14236 21862-21867 NN denotes cells
T14237 21868-21870 IN denotes of
T14238 21871-21874 DT denotes the
T14239 21875-21881 JJ denotes innate
T14240 21882-21885 CC denotes and
T14241 21886-21894 JJ denotes adaptive
T14242 21895-21901 JJ denotes immune
T14243 21902-21909 NN denotes systems
T14244 21910-21918 VB denotes reflects
T14245 21919-21922 DT denotes the
T14246 21923-21933 NN denotes importance
T14247 21934-21936 IN denotes of
T14248 21937-21941 DT denotes this
T14249 21942-21950 NN denotes cytokine
T14250 21951-21953 IN denotes in
T14251 21954-21957 DT denotes the
T14252 21958-21963 JJ denotes tight
T14253 21964-21974 NN denotes regulation
T14254 21975-21977 IN denotes of
T14255 21978-21981 DT denotes the
T14256 21982-21988 JJ denotes immune
T14257 21989-21997 NN denotes response
T14258 21997-21998 -COMMA- denotes ,
T14259 21999-22001 TO denotes to
T14260 22002-22010 VB denotes minimize
T14261 22011-22020 NN denotes pathology
T14262 22021-22027 IN denotes during
T14263 22028-22037 NN denotes infection
T14264 22039-22044 NN denotes IL-10
T14265 22045-22055 NN denotes expression
T14266 22056-22058 IN denotes by
T14267 22059-22062 NN denotes Th1
T14268 22063-22068 NN denotes cells
T14269 22069-22072 VB denotes has
T14270 22073-22077 VB denotes been
T14271 22078-22086 VB denotes reported
T14272 22087-22089 TO denotes to
T14273 22090-22098 VB denotes regulate
T14274 22099-22102 DT denotes the
T14275 22103-22109 JJ denotes immune
T14276 22110-22118 NN denotes response
T14277 22119-22121 IN denotes in
T14278 22122-22135 NN denotes leishmaniasis
T14279 22136-22139 CC denotes and
T14280 22140-22153 NN denotes toxoplasmosis
T14281 22155-22162 RB denotes However
T14282 22162-22163 -COMMA- denotes ,
T14283 22164-22166 IN denotes in
T14284 22167-22171 JJ denotes many
T14285 22172-22182 NN denotes situations
T14286 22182-22183 -COMMA- denotes ,
T14287 22184-22189 NN denotes IL-10
T14288 22190-22192 VB denotes is
T14289 22193-22196 RB denotes not
T14290 22197-22205 VB denotes produced
T14291 22206-22208 IN denotes by
T14292 22209-22212 NN denotes Th1
T14293 22213-22218 NN denotes cells
T14294 22219-22221 IN denotes in
T14295 22222-22230 NN denotes response
T14296 22231-22233 TO denotes to
T14297 22234-22243 JJ denotes antigenic
T14298 22244-22255 NN denotes stimulation
T14299 22257-22260 PRP-DOLLAR- denotes Our
T14300 22261-22265 NN denotes goal
T14301 22266-22269 VB denotes was
T14302 22270-22272 TO denotes to
T14303 22273-22280 VB denotes address
T14304 22281-22284 DT denotes the
T14305 22285-22294 JJ denotes molecular
T14306 22295-22302 NN denotes signals
T14307 22303-22307 WDT denotes that
T14308 22308-22317 VB denotes determine
T14309 22318-22325 IN denotes whether
T14310 22326-22329 NN denotes Th1
T14311 22330-22335 NN denotes cells
T14312 22336-22343 VB denotes develop
T14313 22344-22346 TO denotes to
T14314 22347-22354 VB denotes produce
T14315 22355-22360 NN denotes IL-10
T14316 22361-22362 -LRB- denotes (
T14317 22362-22372 NNP denotes Trinchieri
T14318 22372-22373 -COMMA- denotes ,
T14319 22374-22378 CD denotes 2007
T14320 22378-22379 -RRB- denotes )
T14321 22381-22385 RB denotes Here
T14322 22385-22386 -COMMA- denotes ,
T14323 22387-22389 PRP denotes we
T14324 22390-22396 VB denotes showed
T14325 22397-22401 IN denotes that
T14326 22402-22405 NN denotes Th1
T14327 22406-22411 NN denotes cells
T14328 22412-22420 VB denotes required
T14329 22421-22446 JJ denotes high-antigen-dose-induced
T14330 22447-22451 NN denotes ERK1
T14331 22452-22455 CC denotes and
T14332 22456-22460 NN denotes ERK2
T14333 22461-22476 NN denotes phosphorylation
T14334 22477-22480 CC denotes and
T14335 22481-22494 JJ denotes IL-12-induced
T14336 22495-22501 NN denotes STAT-4
T14337 22502-22512 NN denotes activation
T14338 22513-22515 TO denotes to
T14339 22516-22523 VB denotes produce
T14340 22524-22529 NN denotes IL-10
T14341 22531-22534 PRP-DOLLAR- denotes Our
T14342 22535-22543 NN denotes findings
T14343 22544-22548 IN denotes that
T14344 22549-22553 NN denotes ERK1
T14345 22554-22557 CC denotes and
T14346 22558-22562 NN denotes ERK2
T14347 22563-22573 NN denotes activation
T14348 22574-22577 VB denotes was
T14349 22578-22579 DT denotes a
T14350 22580-22586 JJ denotes common
T14351 22587-22594 NN denotes pathway
T14352 22595-22603 VB denotes required
T14353 22604-22607 IN denotes for
T14354 22608-22611 DT denotes the
T14355 22612-22622 NN denotes production
T14356 22623-22625 IN denotes of
T14357 22626-22631 NN denotes IL-10
T14358 22632-22634 IN denotes by
T14359 22635-22638 NN denotes Th1
T14360 22638-22639 -COMMA- denotes ,
T14361 22640-22643 NN denotes Th2
T14362 22643-22644 -COMMA- denotes ,
T14363 22645-22648 CC denotes and
T14364 22649-22653 NN denotes Th17
T14365 22654-22658 NN denotes cell
T14366 22659-22666 NN denotes subsets
T14367 22666-22667 -COMMA- denotes ,
T14368 22668-22673 WDT denotes which
T14369 22674-22687 VB denotes differentiate
T14370 22688-22693 IN denotes along
T14371 22694-22702 JJ denotes distinct
T14372 22703-22711 NN denotes pathways
T14373 22711-22712 -COMMA- denotes ,
T14374 22713-22717 JJ denotes such
T14375 22718-22722 IN denotes that
T14376 22723-22728 NN denotes IL-10
T14377 22729-22737 VB denotes provides
T14378 22738-22739 DT denotes a
T14379 22740-22746 RB denotes highly
T14380 22747-22756 VB denotes regulated
T14381 22757-22765 NN denotes feedback
T14382 22766-22770 NN denotes loop
T14383 22771-22773 TO denotes to
T14384 22774-22779 VB denotes avoid
T14385 22780-22783 DT denotes the
T14386 22784-22792 NN denotes extremes
T14387 22793-22795 IN denotes of
T14388 22796-22805 JJ denotes excessive
T14389 22806-22818 NN denotes inflammation
T14390 22819-22821 CC denotes or
T14391 22822-22829 JJ denotes chronic
T14392 22830-22840 NN denotes infections
T14393 22841-22844 CC denotes and
T14394 22845-22849 RB denotes also
T14395 22850-22855 VB denotes allow
T14396 22856-22857 DT denotes a
T14397 22858-22868 JJ denotes protective
T14398 22869-22877 NN denotes response
T14399 22878-22880 TO denotes to
T14400 22881-22888 JJ denotes diverse
T14401 22889-22898 NN denotes pathogens
T14402 22900-22902 IN denotes In
T14403 22903-22910 JJ denotes certain
T14404 22911-22916 JJ denotes viral
T14405 22917-22919 CC denotes or
T14406 22920-22929 JJ denotes parasitic
T14407 22930-22940 NN denotes infections
T14408 22941-22942 -LRB- denotes (
T14409 22942-22950 NNP denotes Anderson
T14410 22951-22957 NNP denotes et al.
T14411 22957-22958 -COMMA- denotes ,
T14412 22959-22963 CD denotes 2007
T14413 22963-22964 -COLON- denotes ;
T14414 22965-22971 NNP denotes Brooks
T14415 22972-22978 FW denotes et al.
T14416 22978-22979 -COMMA- denotes ,
T14417 22980-22984 CD denotes 2006
T14418 22984-22985 -COLON- denotes ;
T14419 22986-22993 FW denotes Ejrnaes
T14420 22994-23000 FW denotes et al.
T14421 23000-23001 -COMMA- denotes ,
T14422 23002-23006 CD denotes 2006
T14423 23006-23007 -RRB- denotes )
T14424 23007-23008 -COMMA- denotes ,
T14425 23009-23013 JJ denotes high
T14426 23014-23021 NN denotes amounts
T14427 23022-23024 IN denotes of
T14428 23025-23036 NN denotes stimulation
T14429 23037-23040 MD denotes may
T14430 23041-23045 VB denotes lead
T14431 23046-23048 TO denotes to
T14432 23049-23052 DT denotes the
T14433 23053-23060 JJ denotes chronic
T14434 23061-23071 JJ denotes nonhealing
T14435 23072-23081 NN denotes infection
T14436 23082-23087 VB denotes shown
T14437 23088-23090 TO denotes to
T14438 23091-23093 VB denotes be
T14439 23094-23103 VB denotes regulated
T14440 23104-23106 IN denotes by
T14441 23107-23112 NN denotes IL-10
T14442 23114-23120 IN denotes During
T14443 23121-23124 DT denotes the
T14444 23125-23131 NN denotes course
T14445 23132-23134 IN denotes of
T14446 23135-23144 NN denotes infection
T14447 23144-23145 -COMMA- denotes ,
T14448 23146-23151 IN denotes after
T14449 23152-23159 JJ denotes initial
T14450 23160-23170 NN denotes triggering
T14451 23171-23175 IN denotes with
T14452 23176-23183 NN denotes antigen
T14453 23183-23184 -COMMA- denotes ,
T14454 23185-23192 NN denotes T cells
T14455 23193-23200 VB denotes migrate
T14456 23201-23203 TO denotes to
T14457 23204-23207 DT denotes the
T14458 23208-23214 NN denotes tissue
T14459 23215-23227 VB denotes encountering
T14460 23228-23232 JJ denotes high
T14461 23233-23238 NN denotes doses
T14462 23239-23241 IN denotes of
T14463 23242-23249 NN denotes antigen
T14464 23250-23253 CC denotes and
T14465 23254-23261 NN denotes factors
T14466 23262-23270 VB denotes produced
T14467 23271-23273 IN denotes by
T14468 23274-23277 DT denotes the
T14469 23278-23284 JJ denotes innate
T14470 23285-23291 JJ denotes immune
T14471 23292-23300 NN denotes response
T14472 23302-23307 IN denotes Under
T14473 23308-23313 DT denotes these
T14474 23314-23324 NN denotes conditions
T14475 23324-23325 -COMMA- denotes ,
T14476 23326-23328 PRP denotes we
T14477 23329-23338 VB denotes speculate
T14478 23339-23343 IN denotes that
T14479 23344-23347 NN denotes Th1
T14480 23348-23353 NN denotes cells
T14481 23354-23358 MD denotes will
T14482 23359-23361 VB denotes be
T14483 23362-23369 VB denotes induced
T14484 23370-23372 TO denotes to
T14485 23373-23380 VB denotes express
T14486 23381-23385 JJ denotes high
T14487 23386-23393 NN denotes amounts
T14488 23394-23396 IN denotes of
T14489 23397-23402 NN denotes IL-10
T14490 23402-23403 -COMMA- denotes ,
T14491 23404-23406 IN denotes in
T14492 23407-23414 VB denotes keeping
T14493 23415-23419 IN denotes with
T14494 23420-23427 NN denotes reports
T14495 23428-23432 IN denotes that
T14496 23433-23448 JJ denotes IL-10-producing
T14497 23449-23452 NN denotes Th1
T14498 23453-23458 NN denotes cells
T14499 23459-23463 VB denotes were
T14500 23464-23469 VB denotes found
T14501 23470-23472 IN denotes in
T14502 23473-23477 JJ denotes CD4+
T14503 23478-23484 NN denotes clones
T14504 23485-23493 VB denotes isolated
T14505 23494-23498 IN denotes from
T14506 23499-23502 NN denotes BAL
T14507 23503-23506 CC denotes but
T14508 23507-23510 RB denotes not
T14509 23511-23516 NN denotes blood
T14510 23517-23519 IN denotes of
T14511 23520-23522 NN denotes TB
T14512 23523-23531 NN denotes patients
T14513 23532-23533 -LRB- denotes (
T14514 23533-23539 NNP denotes Gerosa
T14515 23540-23546 NNP denotes et al.
T14516 23546-23547 -COMMA- denotes ,
T14517 23548-23552 CD denotes 1999
T14518 23552-23553 -RRB- denotes )
T14519 23555-23564 RB denotes Similarly
T14520 23564-23565 -COMMA- denotes ,
T14521 23566-23569 DT denotes the
T14522 23570-23576 JJ denotes immune
T14523 23577-23585 NN denotes response
T14524 23586-23588 TO denotes to
T14525 23589-23590 DT denotes a
T14526 23591-23599 JJ denotes clinical
T14527 23600-23607 NN denotes isolate
T14528 23608-23610 IN denotes of
T14529 23611-23613 NNP denotes L.
T14530 23614-23619 JJ denotes major
T14531 23619-23620 -COMMA- denotes ,
T14532 23621-23626 WDT denotes which
T14533 23627-23635 VB denotes produces
T14534 23636-23643 RB denotes heavily
T14535 23644-23652 JJ denotes infected
T14536 23653-23663 JJ denotes nonhealing
T14537 23664-23671 NN denotes lesions
T14538 23671-23672 -COMMA- denotes ,
T14539 23673-23676 VB denotes was
T14540 23677-23682 VB denotes found
T14541 23683-23685 TO denotes to
T14542 23686-23688 VB denotes be
T14543 23689-23698 VB denotes regulated
T14544 23699-23701 IN denotes by
T14545 23702-23707 NN denotes IL-10
T14546 23708-23715 VB denotes derived
T14547 23716-23720 IN denotes from
T14548 23721-23727 NN denotes Foxp3−
T14549 23728-23731 NN denotes Th1
T14550 23732-23737 NN denotes cells
T14551 23738-23742 WDT denotes that
T14552 23743-23752 VB denotes coproduce
T14553 23753-23758 NN denotes IL-10
T14554 23759-23762 CC denotes and
T14555 23763-23768 NN denotes IFN-γ
T14556 23769-23770 -LRB- denotes (
T14557 23770-23778 NNP denotes Anderson
T14558 23779-23785 NNP denotes et al.
T14559 23785-23786 -COMMA- denotes ,
T14560 23787-23791 CD denotes 2007
T14561 23791-23792 -RRB- denotes )
T14562 23792-23793 -COMMA- denotes ,
T14563 23794-23797 CC denotes and
T14564 23798-23801 DT denotes the
T14565 23802-23808 JJ denotes immune
T14566 23809-23817 NN denotes response
T14567 23818-23824 IN denotes during
T14568 23825-23827 FW denotes T.
T14569 23828-23834 FW denotes gondii
T14570 23835-23844 NN denotes infection
T14571 23845-23848 VB denotes was
T14572 23849-23854 VB denotes found
T14573 23855-23859 RB denotes also
T14574 23860-23862 TO denotes to
T14575 23863-23865 VB denotes be
T14576 23866-23875 VB denotes regulated
T14577 23876-23878 IN denotes by
T14578 23879-23885 NN denotes Foxp3−
T14579 23886-23889 NN denotes Th1
T14580 23890-23895 NN denotes cells
T14581 23896-23897 -LRB- denotes (
T14582 23897-23905 JJ denotes Jankovic
T14583 23906-23912 NN denotes et al.
T14584 23912-23913 -COMMA- denotes ,
T14585 23914-23918 CD denotes 2007
T14586 23918-23919 -RRB- denotes )
T14587 23921-23923 PRP denotes It
T14588 23924-23926 VB denotes is
T14589 23927-23933 JJ denotes likely
T14590 23934-23938 IN denotes that
T14591 23939-23944 NN denotes IL-10
T14592 23945-23955 NN denotes production
T14593 23956-23958 IN denotes by
T14594 23959-23962 NN denotes Th1
T14595 23963-23968 NN denotes cells
T14596 23969-23971 VB denotes is
T14597 23972-23978 VB denotes evoked
T14598 23979-23984 IN denotes under
T14599 23985-23995 NN denotes conditions
T14600 23996-23998 IN denotes of
T14601 23999-24003 JJ denotes high
T14602 24004-24016 NN denotes inflammation
T14603 24017-24020 CC denotes and
T14604 24021-24030 JJ denotes antigenic
T14605 24031-24042 NN denotes stimulation
T14606 24042-24043 -COMMA- denotes ,
T14607 24044-24051 IN denotes whereas
T14608 24052-24062 JJ denotes regulatory
T14609 24063-24067 JJ denotes CD4+
T14610 24068-24075 NN denotes T cells
T14611 24076-24085 VB denotes producing
T14612 24086-24091 NN denotes IL-10
T14613 24092-24095 MD denotes may
T14614 24096-24103 VB denotes operate
T14615 24104-24106 TO denotes to
T14616 24107-24115 VB denotes regulate
T14617 24116-24119 DT denotes the
T14618 24120-24126 JJ denotes immune
T14619 24127-24135 NN denotes response
T14620 24136-24141 IN denotes under
T14621 24142-24152 NN denotes conditions
T14622 24153-24155 IN denotes in
T14623 24156-24161 WDT denotes which
T14624 24162-24165 DT denotes the
T14625 24166-24174 NN denotes pathogen
T14626 24175-24177 VB denotes is
T14627 24178-24188 RB denotes clinically
T14628 24189-24199 VB denotes controlled
T14629 24199-24200 -COMMA- denotes ,
T14630 24201-24205 JJ denotes such
T14631 24206-24208 IN denotes as
T14632 24209-24211 IN denotes in
T14633 24212-24221 NN denotes infection
T14634 24222-24226 IN denotes with
T14635 24227-24229 FW denotes L.
T14636 24230-24235 JJ denotes major
T14637 24236-24237 -LRB- denotes (
T14638 24237-24245 NN denotes Friedlin
T14639 24246-24252 NN denotes strain
T14640 24252-24253 -RRB- denotes )
T14641 24254-24255 -LRB- denotes (
T14642 24255-24262 NNP denotes Belkaid
T14643 24263-24269 NNP denotes et al.
T14644 24269-24270 -COMMA- denotes ,
T14645 24271-24275 CD denotes 2002
T14646 24275-24276 -COLON- denotes ;
T14647 24277-24283 NNP denotes Suffia
T14648 24284-24290 FW denotes et al.
T14649 24290-24291 -COMMA- denotes ,
T14650 24292-24296 CD denotes 2006
T14651 24296-24297 -RRB- denotes )
T14652 24299-24301 PRP denotes We
T14653 24302-24305 RB denotes now
T14654 24306-24310 RB denotes also
T14655 24311-24319 VB denotes reported
T14656 24320-24324 IN denotes that
T14657 24325-24329 JJ denotes CD4+
T14658 24330-24337 NN denotes T cells
T14659 24338-24346 VB denotes cultured
T14660 24347-24351 IN denotes with
T14661 24352-24356 JJ denotes high
T14662 24357-24364 NN denotes antigen
T14663 24365-24369 NN denotes dose
T14664 24370-24373 CC denotes and
T14665 24374-24379 NN denotes IL-12
T14666 24380-24393 VB denotes differentiate
T14667 24394-24398 IN denotes into
T14668 24399-24408 JJ denotes canonical
T14669 24409-24412 NN denotes Th1
T14670 24413-24421 NN denotes effector
T14671 24422-24427 NN denotes cells
T14672 24427-24428 -COMMA- denotes ,
T14673 24429-24434 WDT denotes which
T14674 24434-24435 -COMMA- denotes ,
T14675 24436-24438 IN denotes in
T14676 24439-24447 NN denotes addition
T14677 24448-24450 TO denotes to
T14678 24451-24461 VB denotes expressing
T14679 24462-24467 JJ denotes large
T14680 24468-24475 NN denotes amounts
T14681 24476-24478 IN denotes of
T14682 24479-24484 NN denotes IFN-γ
T14683 24485-24488 CC denotes and
T14684 24489-24494 NN denotes IL-10
T14685 24494-24495 -COMMA- denotes ,
T14686 24496-24500 VB denotes lose
T14687 24501-24506 PRP-DOLLAR- denotes their
T14688 24507-24511 NN denotes IL-2
T14689 24512-24522 NN denotes expression
T14690 24523-24525 IN denotes as
T14691 24526-24535 VB denotes described
T14692 24536-24542 RB denotes before
T14693 24543-24545 IN denotes in
T14694 24546-24553 JJ denotes certain
T14695 24554-24561 JJ denotes chronic
T14696 24562-24571 NN denotes infection
T14697 24572-24578 NN denotes models
T14698 24579-24580 -LRB- denotes (
T14699 24580-24588 NNP denotes Sallusto
T14700 24589-24595 NNP denotes et al.
T14701 24595-24596 -COMMA- denotes ,
T14702 24597-24601 CD denotes 2004
T14703 24601-24602 -RRB- denotes )
T14704 24604-24607 PRP-DOLLAR- denotes Our
T14705 24608-24621 NN denotes demonstration
T14706 24622-24626 IN denotes that
T14707 24627-24631 NN denotes loss
T14708 24632-24634 IN denotes of
T14709 24635-24639 NN denotes IL-2
T14710 24640-24642 VB denotes is
T14711 24643-24654 VB denotes accompanied
T14712 24655-24657 IN denotes by
T14713 24658-24668 NN denotes production
T14714 24669-24671 IN denotes of
T14715 24672-24677 NN denotes IL-10
T14716 24678-24684 VB denotes offers
T14717 24685-24694 JJ denotes potential
T14718 24695-24705 JJ denotes additional
T14719 24706-24716 NN denotes mechanisms
T14720 24717-24724 WRB denotes whereby
T14721 24725-24733 NN denotes effector
T14722 24734-24740 NN denotes T cell
T14723 24741-24750 NN denotes responses
T14724 24751-24754 MD denotes may
T14725 24755-24757 VB denotes be
T14726 24758-24766 VB denotes dampened
T14727 24767-24773 IN denotes during
T14728 24774-24781 JJ denotes chronic
T14729 24782-24789 NN denotes disease
T14730 24791-24796 VB denotes Using
T14731 24797-24799 DT denotes an
T14732 24800-24807 FW denotes in vivo
T14733 24808-24816 NN denotes transfer
T14734 24817-24822 NN denotes model
T14735 24823-24825 IN denotes of
T14736 24826-24833 NN denotes DO11.10
T14737 24834-24837 NN denotes TCR
T14738 24838-24848 JJ denotes transgenic
T14739 24849-24854 NN denotes cells
T14740 24855-24856 -LRB- denotes (
T14741 24856-24862 NNP denotes Castro
T14742 24863-24869 FW denotes et al.
T14743 24869-24870 -COMMA- denotes ,
T14744 24871-24875 CD denotes 2000
T14745 24875-24876 -RRB- denotes )
T14746 24876-24877 -COMMA- denotes ,
T14747 24878-24880 PRP denotes we
T14748 24881-24887 VB denotes showed
T14749 24888-24892 IN denotes that
T14750 24893-24908 JJ denotes IL-10-producing
T14751 24909-24912 NN denotes Th1
T14752 24913-24918 NN denotes cells
T14753 24919-24923 VB denotes were
T14754 24924-24938 VB denotes differentiated
T14755 24939-24941 IN denotes in
T14756 24942-24945 DT denotes the
T14757 24946-24954 NN denotes presence
T14758 24955-24957 IN denotes of
T14759 24958-24962 JJ denotes high
T14760 24963-24968 NN denotes doses
T14761 24969-24971 IN denotes of
T14762 24972-24975 NN denotes OVA
T14763 24976-24983 NN denotes protein
T14764 24984-24987 CC denotes and
T14765 24988-24991 NN denotes LPS
T14766 24993-24995 PRP denotes We
T14767 24996-25002 VB denotes showed
T14768 25003-25007 RB denotes here
T14769 25008-25012 IN denotes that
T14770 25013-25017 DT denotes this
T14771 25018-25027 NN denotes induction
T14772 25028-25030 IN denotes of
T14773 25031-25036 NN denotes IL-10
T14774 25037-25043 NN denotes in Th1
T14775 25044-25049 NN denotes cells
T14776 25050-25057 FW denotes in vivo
T14777 25058-25061 VB denotes was
T14778 25062-25070 RB denotes markedly
T14779 25070-25071 -COMMA- denotes ,
T14780 25072-25075 CC denotes but
T14781 25076-25079 RB denotes not
T14782 25080-25087 RB denotes totally
T14783 25087-25088 -COMMA- denotes ,
T14784 25089-25096 VB denotes reduced
T14785 25097-25099 IN denotes in
T14786 25100-25115 JJ denotes STAT4-deficient
T14787 25116-25123 NN denotes T cells
T14788 25124-25126 IN denotes as
T14789 25127-25135 VB denotes observed
T14790 25136-25142 IN denotes during
T14791 25143-25145 FW denotes T.
T14792 25146-25152 NN denotes gondii
T14793 25153-25162 NN denotes infection
T14794 25163-25164 -LRB- denotes (
T14795 25164-25172 NNP denotes Jankovic
T14796 25173-25179 NNP denotes et al.
T14797 25179-25180 -COMMA- denotes ,
T14798 25181-25185 CD denotes 2002
T14799 25185-25186 -RRB- denotes )
T14800 25188-25189 DT denotes A
T14801 25190-25194 JJ denotes high
T14802 25195-25204 JJ denotes antigenic
T14803 25205-25215 NN denotes activation
T14804 25216-25222 IN denotes during
T14805 25223-25225 FW denotes T.
T14806 25226-25232 FW denotes gondii
T14807 25233-25242 NN denotes infection
T14808 25243-25245 CC denotes or
T14809 25246-25250 JJ denotes high
T14810 25251-25258 NN denotes antigen
T14811 25259-25264 NN denotes doses
T14812 25265-25274 VB denotes delivered
T14813 25275-25277 IN denotes in
T14814 25278-25281 DT denotes the
T14815 25282-25290 NN denotes presence
T14816 25291-25293 IN denotes of
T14817 25294-25297 NN denotes LPS
T14818 25297-25298 -COMMA- denotes ,
T14819 25299-25301 IN denotes as
T14820 25302-25306 VB denotes seen
T14821 25307-25309 IN denotes in
T14822 25310-25313 PRP-DOLLAR- denotes our
T14823 25314-25320 NN denotes system
T14824 25320-25321 -COMMA- denotes ,
T14825 25322-25325 MD denotes may
T14826 25326-25336 VB denotes compensate
T14827 25337-25340 IN denotes for
T14828 25341-25343 DT denotes an
T14829 25344-25352 JJ denotes absolute
T14830 25353-25364 NN denotes requirement
T14831 25365-25368 IN denotes for
T14832 25369-25374 NN denotes IL-12
T14833 25375-25377 IN denotes in
T14834 25378-25381 DT denotes the
T14835 25382-25391 NN denotes induction
T14836 25392-25394 IN denotes of
T14837 25395-25400 NN denotes IL-10
T14838 25401-25403 IN denotes by
T14839 25404-25407 NN denotes Th1
T14840 25408-25413 NN denotes cells
T14841 25415-25417 IN denotes In
T14842 25418-25421 PRP-DOLLAR- denotes our
T14843 25422-25430 FW denotes in vitro
T14844 25431-25437 NN denotes system
T14845 25437-25438 -COMMA- denotes ,
T14846 25439-25447 VB denotes repeated
T14847 25448-25459 NN denotes stimulation
T14848 25460-25462 IN denotes of
T14849 25463-25466 NN denotes Th1
T14850 25467-25472 NN denotes cells
T14851 25473-25477 IN denotes with
T14852 25478-25482 JJ denotes high
T14853 25483-25490 NN denotes antigen
T14854 25491-25496 NN denotes doses
T14855 25497-25504 VB denotes allowed
T14856 25505-25508 DT denotes the
T14857 25509-25520 NN denotes development
T14858 25521-25523 IN denotes of
T14859 25524-25527 NN denotes Th1
T14860 25528-25533 NN denotes cells
T14861 25534-25543 VB denotes producing
T14862 25544-25549 NN denotes IL-10
T14863 25550-25552 IN denotes in
T14864 25553-25555 DT denotes an
T14865 25556-25571 JJ denotes IL-12-dependent
T14866 25572-25578 NN denotes manner
T14867 25580-25585 NN denotes IL-10
T14868 25586-25596 NN denotes production
T14869 25597-25599 IN denotes by
T14870 25600-25603 NN denotes Th1
T14871 25604-25609 NN denotes cells
T14872 25610-25617 VB denotes induced
T14873 25618-25620 IN denotes by
T14874 25621-25625 JJ denotes high
T14875 25626-25633 NN denotes antigen
T14876 25634-25638 NN denotes dose
T14877 25639-25642 CC denotes and
T14878 25643-25648 NN denotes IL-12
T14879 25649-25652 VB denotes was
T14880 25653-25664 JJ denotes independent
T14881 25665-25667 IN denotes of
T14882 25668-25673 NN denotes IFN-γ
T14883 25673-25674 -COMMA- denotes ,
T14884 25675-25677 IN denotes in
T14885 25678-25685 VB denotes keeping
T14886 25686-25690 IN denotes with
T14887 25691-25699 JJ denotes previous
T14888 25700-25708 NN denotes findings
T14889 25709-25710 -LRB- denotes (
T14890 25710-25718 NNP denotes Jankovic
T14891 25719-25725 NNP denotes et al.
T14892 25725-25726 -COMMA- denotes ,
T14893 25727-25731 CD denotes 2002
T14894 25731-25732 -RRB- denotes )
T14895 25734-25741 RB denotes However
T14896 25741-25742 -COMMA- denotes ,
T14897 25743-25744 DT denotes a
T14898 25745-25749 NN denotes role
T14899 25750-25753 IN denotes for
T14900 25754-25759 NN denotes IFN-γ
T14901 25760-25762 IN denotes in
T14902 25763-25772 VB denotes mediating
T14903 25773-25778 NN denotes IL-10
T14904 25779-25791 NN denotes reactivation
T14905 25792-25794 IN denotes by
T14906 25795-25798 NN denotes Th1
T14907 25799-25804 NN denotes cells
T14908 25805-25811 IN denotes during
T14909 25812-25821 JJ denotes secondary
T14910 25822-25831 NN denotes infection
T14911 25832-25836 IN denotes with
T14912 25837-25839 NNP denotes T.
T14913 25840-25846 NN denotes gondii
T14914 25847-25850 VB denotes has
T14915 25851-25855 VB denotes been
T14916 25856-25865 VB denotes suggested
T14917 25866-25867 -LRB- denotes (
T14918 25867-25871 NNP denotes Shaw
T14919 25872-25878 NNP denotes et al.
T14920 25878-25879 -COMMA- denotes ,
T14921 25880-25884 CD denotes 2006
T14922 25884-25885 -RRB- denotes )
T14923 25887-25889 PRP denotes We
T14924 25890-25894 VB denotes have
T14925 25895-25900 VB denotes found
T14926 25901-25905 IN denotes that
T14927 25906-25910 JJ denotes CD4+
T14928 25911-25918 NN denotes T cells
T14929 25919-25926 VB denotes exposed
T14930 25927-25929 TO denotes to
T14931 25930-25931 DT denotes a
T14932 25932-25936 JJ denotes high
T14933 25937-25941 NN denotes dose
T14934 25942-25944 IN denotes of
T14935 25945-25952 NN denotes antigen
T14936 25953-25955 VB denotes do
T14937 25956-25959 RB denotes not
T14938 25960-25967 VB denotes express
T14939 25968-25973 NN denotes IL-10
T14940 25974-25978 IN denotes upon
T14941 25979-25992 NN denotes restimulation
T14942 25992-25993 -COMMA- denotes ,
T14943 25994-25997 CC denotes but
T14944 25998-26001 MD denotes can
T14945 26002-26004 VB denotes be
T14946 26005-26012 VB denotes induced
T14947 26013-26015 TO denotes to
T14948 26016-26023 VB denotes produce
T14949 26024-26029 NN denotes IL-10
T14950 26030-26034 IN denotes upon
T14951 26035-26046 NN denotes re-exposure
T14952 26047-26049 TO denotes to
T14953 26050-26051 DT denotes a
T14954 26052-26056 JJ denotes high
T14955 26057-26061 NN denotes dose
T14956 26062-26064 IN denotes of
T14957 26065-26072 NN denotes antigen
T14958 26073-26075 IN denotes in
T14959 26076-26079 DT denotes the
T14960 26080-26086 NN denotes recall
T14961 26087-26092 NN denotes phase
T14962 26093-26095 IN denotes in
T14963 26096-26099 DT denotes the
T14964 26100-26107 NN denotes absence
T14965 26108-26110 IN denotes of
T14966 26111-26116 VB denotes added
T14967 26117-26122 NN denotes IL-12
T14968 26124-26131 RB denotes However
T14969 26131-26132 -COMMA- denotes ,
T14970 26133-26137 DT denotes this
T14971 26138-26140 VB denotes is
T14972 26141-26150 JJ denotes dependent
T14973 26151-26153 IN denotes on
T14974 26154-26157 DT denotes the
T14975 26158-26167 NN denotes induction
T14976 26168-26170 IN denotes of
T14977 26171-26176 NN denotes IL-12
T14978 26177-26179 IN denotes by
T14979 26180-26198 JJ denotes antigen-presenting
T14980 26199-26202 NN denotes DCs
T14981 26204-26207 DT denotes The
T14982 26208-26219 NN denotes combination
T14983 26220-26222 IN denotes of
T14984 26223-26227 CC denotes both
T14985 26228-26232 JJ denotes high
T14986 26233-26240 NN denotes antigen
T14987 26241-26245 NN denotes dose
T14988 26246-26249 CC denotes and
T14989 26250-26255 NN denotes IL-12
T14990 26256-26264 VB denotes resulted
T14991 26265-26267 IN denotes in
T14992 26268-26271 DT denotes the
T14993 26272-26279 JJ denotes highest
T14994 26280-26286 NN denotes levels
T14995 26287-26289 IN denotes of
T14996 26290-26295 NN denotes IL-10
T14997 26296-26306 NN denotes production
T14998 26307-26310 CC denotes and
T14999 26311-26321 VB denotes correlated
T15000 26322-26326 IN denotes with
T15001 26327-26330 DT denotes the
T15002 26331-26335 JJ denotes high
T15003 26336-26342 NN denotes levels
T15004 26343-26345 IN denotes of
T15005 26346-26350 NN denotes ERK1
T15006 26351-26354 CC denotes and
T15007 26355-26359 NN denotes ERK2
T15008 26360-26370 NN denotes activation
T15009 26372-26375 DT denotes The
T15010 26376-26385 VB denotes increased
T15011 26386-26396 NN denotes expression
T15012 26397-26399 IN denotes of
T15013 26400-26405 NN denotes IFN-γ
T15014 26406-26414 VB denotes observed
T15015 26415-26421 IN denotes during
T15016 26422-26425 DT denotes the
T15017 26426-26435 JJ denotes secondary
T15018 26436-26441 NN denotes phase
T15019 26442-26446 MD denotes will
T15020 26447-26453 VB denotes induce
T15021 26454-26463 VB denotes increased
T15022 26464-26469 NN denotes IL-12
T15023 26470-26480 NN denotes production
T15024 26481-26483 IN denotes by
T15025 26484-26487 NN denotes DCs
T15026 26488-26491 CC denotes and
T15027 26492-26500 VB denotes suggests
T15028 26501-26505 IN denotes that
T15029 26506-26514 VB denotes repeated
T15030 26515-26525 JJ denotes high-level
T15031 26526-26529 NN denotes TCR
T15032 26530-26540 NN denotes activation
T15033 26541-26546 VB denotes feeds
T15034 26547-26551 RB denotes back
T15035 26552-26554 TO denotes to
T15036 26555-26565 VB denotes upregulate
T15037 26566-26571 NN denotes IL-12
T15038 26572-26582 NN denotes production
T15039 26583-26585 IN denotes by
T15040 26586-26588 NN denotes DC
T15041 26590-26592 PRP denotes It
T15042 26593-26595 VB denotes is
T15043 26596-26600 RB denotes thus
T15044 26601-26607 JJ denotes likely
T15045 26608-26612 IN denotes that
T15046 26613-26615 IN denotes in
T15047 26616-26618 FW denotes T.
T15048 26619-26625 FW denotes gondii
T15049 26626-26635 NN denotes infection
T15050 26636-26643 FW denotes in vivo
T15051 26644-26645 -LRB- denotes (
T15052 26645-26649 NNP denotes Shaw
T15053 26650-26656 NNP denotes et al.
T15054 26656-26657 -COMMA- denotes ,
T15055 26658-26662 CD denotes 2006
T15056 26662-26663 -RRB- denotes )
T15057 26663-26664 -COMMA- denotes ,
T15058 26665-26668 DT denotes the
T15059 26669-26680 NN denotes requirement
T15060 26681-26684 IN denotes for
T15061 26685-26690 NN denotes IFN-γ
T15062 26691-26693 TO denotes to
T15063 26694-26700 VB denotes induce
T15064 26701-26706 NN denotes IL-10
T15065 26706-26707 -COMMA- denotes ,
T15066 26708-26711 VB denotes was
T15067 26712-26715 IN denotes for
T15068 26716-26724 NN denotes feedback
T15069 26725-26737 NN denotes upregulation
T15070 26738-26740 IN denotes of
T15071 26741-26746 NN denotes IL-12
T15072 26747-26749 IN denotes by
T15073 26750-26753 NN denotes DCs
T15074 26753-26754 -COMMA- denotes ,
T15075 26755-26760 WDT denotes which
T15076 26761-26763 IN denotes in
T15077 26764-26768 NN denotes turn
T15078 26769-26776 VB denotes induced
T15079 26777-26782 NN denotes IL-10
T15080 26783-26785 IN denotes in
T15081 26786-26789 DT denotes the
T15082 26790-26793 NN denotes Th1
T15083 26794-26799 NN denotes cells
T15084 26801-26809 IN denotes Although
T15085 26810-26815 NN denotes IL-10
T15086 26816-26819 MD denotes may
T15087 26820-26822 VB denotes be
T15088 26823-26837 RB denotes differentially
T15089 26838-26847 VB denotes regulated
T15090 26848-26850 IN denotes in
T15091 26851-26854 NN denotes Th1
T15092 26855-26858 CC denotes and
T15093 26859-26862 NN denotes Th2
T15094 26863-26868 NN denotes cells
T15095 26869-26871 IN denotes as
T15096 26872-26875 VB denotes has
T15097 26876-26880 VB denotes been
T15098 26881-26889 VB denotes reported
T15099 26890-26891 -LRB- denotes (
T15100 26891-26896 NNP denotes Chang
T15101 26897-26903 NNP denotes et al.
T15102 26903-26904 -COMMA- denotes ,
T15103 26905-26909 CD denotes 2007
T15104 26909-26910 -COLON- denotes ;
T15105 26911-26915 NNP denotes Wang
T15106 26916-26922 FW denotes et al.
T15107 26922-26923 -COMMA- denotes ,
T15108 26924-26928 CD denotes 2005
T15109 26928-26929 -RRB- denotes )
T15110 26929-26930 -COMMA- denotes ,
T15111 26931-26935 DT denotes some
T15112 26936-26943 NN denotes studies
T15113 26944-26951 VB denotes suggest
T15114 26952-26955 DT denotes the
T15115 26956-26965 NN denotes existence
T15116 26966-26968 IN denotes of
T15117 26969-26975 JJ denotes common
T15118 26976-26984 NN denotes pathways
T15119 26984-26985 -COMMA- denotes ,
T15120 26986-26989 CC denotes but
T15121 26990-26993 DT denotes the
T15122 26994-27003 JJ denotes molecular
T15123 27004-27009 NN denotes basis
T15124 27010-27013 IN denotes for
T15125 27014-27019 DT denotes these
T15126 27020-27022 VB denotes is
T15127 27023-27025 RB denotes as
T15128 27026-27029 RB denotes yet
T15129 27030-27037 JJ denotes unclear
T15130 27039-27052 JJ denotes Costimulatory
T15131 27053-27058 NN denotes OX-40
T15132 27059-27066 NN denotes signals
T15133 27067-27071 VB denotes have
T15134 27072-27076 VB denotes been
T15135 27077-27082 VB denotes shown
T15136 27083-27085 TO denotes to
T15137 27086-27096 RB denotes negatively
T15138 27097-27105 VB denotes regulate
T15139 27106-27111 NN denotes IL-10
T15140 27112-27122 NN denotes production
T15141 27123-27124 -LRB- denotes (
T15142 27124-27127 NNP denotes Ito
T15143 27128-27134 NNP denotes et al.
T15144 27134-27135 -COMMA- denotes ,
T15145 27136-27140 CD denotes 2005
T15146 27140-27141 -RRB- denotes )
T15147 27142-27146 CC denotes both
T15148 27147-27149 IN denotes in
T15149 27150-27153 NN denotes Th1
T15150 27154-27157 CC denotes and
T15151 27158-27161 NN denotes Th2
T15152 27162-27167 NN denotes cells
T15153 27167-27168 -COMMA- denotes ,
T15154 27169-27176 IN denotes whereas
T15155 27177-27181 NN denotes ICOS
T15156 27182-27191 NN denotes signaling
T15157 27192-27195 VB denotes has
T15158 27196-27200 VB denotes been
T15159 27201-27210 VB denotes suggested
T15160 27211-27213 TO denotes to
T15161 27214-27220 VB denotes induce
T15162 27221-27226 NN denotes IL-10
T15163 27227-27228 -LRB- denotes (
T15164 27228-27231 NNP denotes Ito
T15165 27232-27238 NNP denotes et al.
T15166 27238-27239 -COMMA- denotes ,
T15167 27240-27244 CD denotes 2007
T15168 27244-27245 -COLON- denotes ;
T15169 27246-27252 NNP denotes Witsch
T15170 27253-27259 NNP denotes et al.
T15171 27259-27260 -COMMA- denotes ,
T15172 27261-27265 CD denotes 2002
T15173 27265-27266 -RRB- denotes )
T15174 27267-27269 IN denotes in
T15175 27270-27274 CC denotes both
T15176 27275-27278 NN denotes Th1
T15177 27279-27282 CC denotes and
T15178 27283-27286 NN denotes Th2
T15179 27287-27292 NN denotes cells
T15180 27294-27301 RB denotes However
T15181 27301-27302 -COMMA- denotes ,
T15182 27303-27305 IN denotes in
T15183 27306-27310 DT denotes some
T15184 27311-27316 NN denotes cases
T15185 27316-27317 -COMMA- denotes ,
T15186 27318-27322 NN denotes ICOS
T15187 27323-27332 NN denotes signaling
T15188 27333-27337 RB denotes also
T15189 27338-27347 VB denotes regulates
T15190 27348-27352 NN denotes IL-4
T15191 27353-27363 NN denotes production
T15192 27364-27367 CC denotes and
T15193 27368-27371 NN denotes Th2
T15194 27372-27381 NN denotes responses
T15195 27382-27383 -LRB- denotes (
T15196 27383-27392 NNP denotes Greenwald
T15197 27393-27399 NNP denotes et al.
T15198 27399-27400 -COMMA- denotes ,
T15199 27401-27405 CD denotes 2005
T15200 27405-27406 -RRB- denotes )
T15201 27408-27410 PRP denotes We
T15202 27411-27414 RB denotes now
T15203 27415-27422 VB denotes provide
T15204 27423-27424 DT denotes a
T15205 27425-27431 JJ denotes common
T15206 27432-27441 NN denotes mechanism
T15207 27442-27444 IN denotes of
T15208 27445-27449 NN denotes ERK1
T15209 27450-27453 CC denotes and
T15210 27454-27458 NN denotes ERK2
T15211 27459-27469 NN denotes activation
T15212 27470-27473 IN denotes for
T15213 27474-27477 DT denotes the
T15214 27478-27488 NN denotes regulation
T15215 27489-27491 IN denotes of
T15216 27492-27497 NN denotes IL-10
T15217 27498-27508 NN denotes production
T15218 27509-27511 IN denotes in
T15219 27512-27515 NN denotes Th1
T15220 27515-27516 -COMMA- denotes ,
T15221 27517-27520 NN denotes Th2
T15222 27520-27521 -COMMA- denotes ,
T15223 27522-27525 CC denotes and
T15224 27526-27530 NN denotes Th17
T15225 27531-27536 NN denotes cells
T15226 27536-27537 -COMMA- denotes ,
T15227 27538-27546 IN denotes although
T15228 27547-27551 DT denotes each
T15229 27552-27558 NN denotes subset
T15230 27559-27573 VB denotes differentiates
T15231 27574-27579 IN denotes along
T15232 27580-27581 DT denotes a
T15233 27582-27590 JJ denotes distinct
T15234 27591-27594 CC denotes and
T15235 27595-27610 JJ denotes subset-specific
T15236 27611-27626 JJ denotes transcriptional
T15237 27627-27634 NN denotes pathway
T15238 27636-27640 DT denotes This
T15239 27641-27651 VB denotes reinforces
T15240 27652-27655 DT denotes the
T15241 27656-27660 NN denotes fact
T15242 27661-27665 IN denotes that
T15243 27666-27671 NN denotes IL-10
T15244 27672-27674 VB denotes is
T15245 27675-27678 RB denotes not
T15246 27679-27680 DT denotes a
T15247 27681-27683 NN denotes Th
T15248 27684-27704 JJ denotes cell-subset-specific
T15249 27705-27713 NN denotes cytokine
T15250 27713-27714 -COMMA- denotes ,
T15251 27715-27718 CC denotes but
T15252 27719-27726 RB denotes instead
T15253 27727-27729 VB denotes is
T15254 27730-27738 VB denotes produced
T15255 27739-27741 IN denotes in
T15256 27742-27743 DT denotes a
T15257 27744-27751 RB denotes tightly
T15258 27752-27761 VB denotes regulated
T15259 27762-27769 NN denotes fashion
T15260 27770-27776 IN denotes during
T15261 27777-27781 DT denotes each
T15262 27782-27797 NN denotes differentiation
T15263 27798-27805 NN denotes pathway
T15264 27807-27809 IN denotes Of
T15265 27810-27814 NN denotes note
T15266 27814-27815 -COMMA- denotes ,
T15267 27816-27817 DT denotes a
T15268 27818-27822 NN denotes role
T15269 27823-27826 IN denotes for
T15270 27827-27831 NN denotes ERK1
T15271 27832-27835 CC denotes and
T15272 27836-27840 NN denotes ERK2
T15273 27841-27851 NN denotes activation
T15274 27852-27854 IN denotes in
T15275 27855-27858 DT denotes the
T15276 27859-27868 NN denotes induction
T15277 27869-27871 IN denotes of
T15278 27872-27877 NN denotes IL-10
T15279 27878-27888 NN denotes production
T15280 27889-27892 VB denotes has
T15281 27893-27900 RB denotes already
T15282 27901-27905 VB denotes been
T15283 27906-27915 VB denotes described
T15284 27916-27919 IN denotes for
T15285 27920-27931 NN denotes macrophages
T15286 27932-27935 CC denotes and
T15287 27936-27938 NN denotes DC
T15288 27939-27940 -LRB- denotes (
T15289 27940-27947 NNP denotes Agrawal
T15290 27948-27954 NNP denotes et al.
T15291 27954-27955 -COMMA- denotes ,
T15292 27956-27960 CD denotes 2006
T15293 27960-27961 -COLON- denotes ;
T15294 27962-27968 NNP denotes Hacker
T15295 27969-27975 FW denotes et al.
T15296 27975-27976 -COMMA- denotes ,
T15297 27977-27981 CD denotes 1999
T15298 27981-27982 -RRB- denotes )
T15299 27984-27996 JJ denotes Differential
T15300 27997-28012 JJ denotes transcriptional
T15301 28013-28023 NN denotes regulation
T15302 28024-28026 IN denotes of
T15303 28027-28032 NN denotes IL-10
T15304 28033-28035 IN denotes in
T15305 28036-28039 NN denotes Th1
T15306 28040-28043 CC denotes and
T15307 28044-28047 NN denotes Th2
T15308 28048-28053 NN denotes cells
T15309 28054-28057 VB denotes has
T15310 28058-28062 VB denotes been
T15311 28063-28072 VB denotes suggested
T15312 28073-28074 -LRB- denotes (
T15313 28074-28079 NNP denotes Chang
T15314 28080-28086 NNP denotes et al.
T15315 28086-28087 -COMMA- denotes ,
T15316 28088-28092 CD denotes 2007
T15317 28092-28093 -COLON- denotes ;
T15318 28094-28098 NNP denotes Wang
T15319 28099-28105 FW denotes et al.
T15320 28105-28106 -COMMA- denotes ,
T15321 28107-28111 CD denotes 2005
T15322 28111-28112 -RRB- denotes )
T15323 28112-28113 -COMMA- denotes ,
T15324 28114-28117 CC denotes and
T15325 28118-28127 JJ denotes extensive
T15326 28128-28135 NN denotes histone
T15327 28136-28147 NN denotes acetylation
T15328 28148-28150 IN denotes of
T15329 28151-28154 DT denotes the
T15330 28155-28160 NN denotes IL-10
T15331 28161-28165 NN denotes gene
T15332 28166-28168 VB denotes is
T15333 28169-28179 JJ denotes detectable
T15334 28180-28182 IN denotes in
T15335 28183-28188 RB denotes fully
T15336 28189-28198 VB denotes polarized
T15337 28199-28202 NN denotes Th2
T15338 28203-28208 NN denotes cells
T15339 28208-28209 -COMMA- denotes ,
T15340 28210-28213 CC denotes but
T15341 28214-28217 RB denotes not
T15342 28218-28221 NN denotes Th1
T15343 28222-28227 NN denotes cells
T15344 28228-28229 -LRB- denotes (
T15345 28229-28234 NNP denotes Chang
T15346 28235-28241 NNP denotes et al.
T15347 28241-28242 -COMMA- denotes ,
T15348 28243-28247 CD denotes 2007
T15349 28247-28248 -RRB- denotes )
T15350 28250-28252 PRP denotes We
T15351 28253-28260 VB denotes provide
T15352 28261-28269 NN denotes evidence
T15353 28270-28274 IN denotes that
T15354 28275-28280 NN denotes IL-10
T15355 28281-28283 VB denotes is
T15356 28284-28292 VB denotes produced
T15357 28293-28295 IN denotes in
T15358 28296-28305 JJ denotes canonical
T15359 28306-28309 NN denotes Th1
T15360 28310-28315 NN denotes cells
T15361 28316-28319 CC denotes and
T15362 28320-28324 IN denotes that
T15363 28325-28328 PRP-DOLLAR- denotes its
T15364 28329-28339 NN denotes expression
T15365 28340-28350 VB denotes correlates
T15366 28351-28355 IN denotes with
T15367 28356-28359 DT denotes the
T15368 28360-28370 NN denotes expression
T15369 28371-28373 IN denotes of
T15370 28374-28379 NN denotes T-bet
T15371 28380-28383 CC denotes and
T15372 28384-28387 DT denotes the
T15373 28388-28395 JJ denotes highest
T15374 28396-28401 NN denotes IFN-γ
T15375 28402-28412 NN denotes production
T15376 28412-28413 -COMMA- denotes ,
T15377 28414-28416 IN denotes in
T15378 28417-28424 VB denotes keeping
T15379 28425-28429 IN denotes with
T15380 28430-28433 PRP-DOLLAR- denotes our
T15381 28434-28446 NN denotes observations
T15382 28447-28451 IN denotes that
T15383 28452-28461 JJ denotes high-dose
T15384 28462-28469 NN denotes antigen
T15385 28470-28481 NN denotes stimulation
T15386 28482-28485 CC denotes and
T15387 28486-28491 NN denotes IL-12
T15388 28492-28501 NN denotes signaling
T15389 28502-28505 VB denotes are
T15390 28506-28514 VB denotes required
T15391 28515-28518 IN denotes for
T15392 28519-28524 NN denotes IL-10
T15393 28525-28528 CC denotes and
T15394 28529-28534 NN denotes IFN-γ
T15395 28535-28545 NN denotes expression
T15396 28547-28549 PRP denotes It
T15397 28550-28553 VB denotes has
T15398 28554-28558 RB denotes also
T15399 28559-28563 VB denotes been
T15400 28564-28569 VB denotes shown
T15401 28570-28574 IN denotes that
T15402 28575-28586 NN denotes maintenance
T15403 28587-28589 IN denotes of
T15404 28590-28595 NN denotes IL-10
T15405 28596-28606 NN denotes expression
T15406 28607-28609 VB denotes is
T15407 28610-28621 JJ denotes conditional
T15408 28622-28624 IN denotes on
T15409 28625-28630 NN denotes IL-12
T15410 28631-28633 CC denotes or
T15411 28634-28638 NN denotes IL-4
T15412 28639-28645 IN denotes unless
T15413 28646-28649 DT denotes the
T15414 28650-28655 NN denotes IL-10
T15415 28656-28660 NN denotes gene
T15416 28661-28663 VB denotes is
T15417 28664-28673 VB denotes imprinted
T15418 28674-28676 IN denotes by
T15419 28677-28683 NN denotes GATA-3
T15420 28684-28685 -LRB- denotes (
T15421 28685-28690 NNP denotes Chang
T15422 28691-28697 NNP denotes et al.
T15423 28697-28698 -COMMA- denotes ,
T15424 28699-28703 CD denotes 2007
T15425 28703-28704 -RRB- denotes )
T15426 28704-28705 -COMMA- denotes ,
T15427 28706-28711 WDT denotes which
T15428 28712-28715 MD denotes can
T15429 28716-28723 VB denotes remodel
T15430 28724-28727 DT denotes the
T15431 28728-28733 NN denotes IL-10
T15432 28734-28739 NN denotes locus
T15433 28739-28740 -COMMA- denotes ,
T15434 28741-28745 RB denotes thus
T15435 28746-28756 VB denotes explaining
T15436 28757-28760 DT denotes the
T15437 28761-28768 JJ denotes highest
T15438 28769-28776 NN denotes amounts
T15439 28777-28779 IN denotes of
T15440 28780-28785 NN denotes IL-10
T15441 28786-28794 VB denotes produced
T15442 28795-28797 IN denotes by
T15443 28798-28801 NN denotes Th2
T15444 28802-28807 NN denotes cells
T15445 28808-28809 -LRB- denotes (
T15446 28809-28814 NNP denotes Chang
T15447 28815-28821 NNP denotes et al.
T15448 28821-28822 -COMMA- denotes ,
T15449 28823-28827 CD denotes 2007
T15450 28827-28828 -COLON- denotes ;
T15451 28829-28838 NNP denotes Shoemaker
T15452 28839-28845 FW denotes et al.
T15453 28845-28846 -COMMA- denotes ,
T15454 28847-28851 CD denotes 2006
T15455 28851-28852 -RRB- denotes )
T15456 28854-28856 PRP denotes We
T15457 28857-28861 VB denotes show
T15458 28862-28866 RB denotes here
T15459 28867-28871 IN denotes that
T15460 28872-28876 JJ denotes high
T15461 28877-28884 NN denotes antigen
T15462 28885-28889 NN denotes dose
T15463 28890-28893 CC denotes and
T15464 28894-28899 NN denotes IL-12
T15465 28900-28911 RB denotes drastically
T15466 28912-28924 VB denotes downregulate
T15467 28925-28931 NN denotes Gata-3
T15468 28932-28942 NN denotes expression
T15469 28942-28943 -COMMA- denotes ,
T15470 28944-28954 VB denotes suggesting
T15471 28955-28959 IN denotes that
T15472 28960-28970 JJ denotes additional
T15473 28971-28978 NN denotes factors
T15474 28979-28982 VB denotes are
T15475 28983-28985 IN denotes in
T15476 28986-28991 NN denotes place
T15477 28992-28994 TO denotes to
T15478 28995-29001 VB denotes induce
T15479 29002-29007 NN denotes IL-10
T15480 29008-29018 NN denotes expression
T15481 29019-29021 IN denotes in
T15482 29022-29025 NN denotes Th1
T15483 29026-29031 NN denotes cells
T15484 29031-29032 -COMMA- denotes ,
T15485 29033-29039 IN denotes albeit
T15486 29040-29051 RB denotes transiently
T15487 29053-29063 NN denotes Expression
T15488 29064-29066 IN denotes of
T15489 29067-29072 NN denotes c-maf
T15490 29073-29076 VB denotes was
T15491 29077-29084 RB denotes greatly
T15492 29085-29095 VB denotes diminished
T15493 29096-29098 IN denotes by
T15494 29099-29103 JJ denotes high
T15495 29104-29111 NN denotes antigen
T15496 29112-29117 NN denotes doses
T15497 29118-29120 IN denotes in
T15498 29121-29128 NN denotes T cells
T15499 29129-29132 CC denotes and
T15500 29133-29136 RB denotes yet
T15501 29137-29140 VB denotes was
T15502 29141-29153 RB denotes unexpectedly
T15503 29154-29164 VB denotes maintained
T15504 29165-29167 IN denotes by
T15505 29168-29173 NN denotes IL-12
T15506 29174-29177 CC denotes and
T15507 29178-29185 JJ denotes present
T15508 29186-29188 IN denotes in
T15509 29189-29193 NN denotes Th17
T15510 29194-29199 NN denotes cells
T15511 29201-29205 DT denotes That
T15512 29206-29211 NN denotes c-maf
T15513 29212-29222 NN denotes expression
T15514 29223-29225 VB denotes is
T15515 29226-29232 JJ denotes common
T15516 29233-29235 TO denotes to
T15517 29236-29251 JJ denotes IL-10-producing
T15518 29252-29255 NN denotes Th1
T15519 29255-29256 -COMMA- denotes ,
T15520 29257-29260 NN denotes Th2
T15521 29260-29261 -COMMA- denotes ,
T15522 29262-29265 CC denotes and
T15523 29266-29270 NN denotes Th17
T15524 29271-29276 NN denotes cells
T15525 29277-29280 CC denotes and
T15526 29280-29281 -COMMA- denotes ,
T15527 29282-29286 IN denotes like
T15528 29287-29292 NN denotes IL-10
T15529 29292-29293 -COMMA- denotes ,
T15530 29294-29296 VB denotes is
T15531 29297-29306 JJ denotes dependent
T15532 29307-29309 IN denotes on
T15533 29310-29313 NN denotes ERK
T15534 29314-29324 NN denotes activation
T15535 29325-29327 IN denotes in
T15536 29328-29331 NN denotes Th1
T15537 29332-29335 CC denotes and
T15538 29336-29340 NN denotes Th17
T15539 29341-29346 NN denotes cells
T15540 29347-29350 IN denotes for
T15541 29351-29354 PRP-DOLLAR- denotes its
T15542 29355-29365 NN denotes expression
T15543 29366-29368 VB denotes is
T15544 29369-29371 IN denotes of
T15545 29372-29380 NN denotes interest
T15546 29381-29388 IN denotes because
T15547 29389-29394 NN denotes c-Maf
T15548 29395-29398 VB denotes has
T15549 29399-29403 VB denotes been
T15550 29404-29409 VB denotes shown
T15551 29410-29412 TO denotes to
T15552 29413-29415 VB denotes be
T15553 29416-29418 DT denotes an
T15554 29419-29428 JJ denotes essential
T15555 29429-29442 NN denotes transcription
T15556 29443-29449 NN denotes factor
T15557 29450-29453 IN denotes for
T15558 29454-29459 NN denotes IL-10
T15559 29460-29470 NN denotes expression
T15560 29471-29473 IN denotes in
T15561 29474-29485 NN denotes macrophages
T15562 29486-29487 -LRB- denotes (
T15563 29487-29490 NNP denotes Cao
T15564 29491-29497 NNP denotes et al.
T15565 29497-29498 -COMMA- denotes ,
T15566 29499-29503 CD denotes 2005
T15567 29503-29504 -RRB- denotes )
T15568 29506-29508 IN denotes In
T15569 29509-29516 NN denotes summary
T15570 29516-29517 -COMMA- denotes ,
T15571 29518-29520 PRP denotes we
T15572 29521-29525 VB denotes show
T15573 29526-29530 IN denotes that
T15574 29531-29539 IN denotes although
T15575 29540-29543 NN denotes Th1
T15576 29543-29544 -COMMA- denotes ,
T15577 29545-29548 NN denotes Th2
T15578 29548-29549 -COMMA- denotes ,
T15579 29550-29553 CC denotes and
T15580 29554-29558 NN denotes Th17
T15581 29559-29563 JJ denotes CD4+
T15582 29564-29570 NN denotes T cell
T15583 29571-29578 NN denotes subsets
T15584 29579-29592 VB denotes differentiate
T15585 29593-29598 IN denotes along
T15586 29599-29607 JJ denotes distinct
T15587 29608-29617 NN denotes signaling
T15588 29618-29621 CC denotes and
T15589 29622-29637 JJ denotes transcriptional
T15590 29638-29646 NN denotes pathways
T15591 29646-29647 -COMMA- denotes ,
T15592 29648-29652 PRP denotes they
T15593 29653-29656 MD denotes can
T15594 29657-29660 DT denotes all
T15595 29661-29663 VB denotes be
T15596 29664-29671 VB denotes induced
T15597 29672-29674 TO denotes to
T15598 29675-29679 VB denotes make
T15599 29680-29685 NN denotes IL-10
T15600 29687-29691 NN denotes ERK1
T15601 29692-29695 CC denotes and
T15602 29696-29700 NN denotes ERK2
T15603 29701-29711 NN denotes activation
T15604 29712-29714 VB denotes is
T15605 29715-29723 VB denotes required
T15606 29724-29727 IN denotes for
T15607 29728-29733 NN denotes IL-10
T15608 29734-29744 NN denotes production
T15609 29745-29747 IN denotes by
T15610 29748-29751 PDT denotes all
T15611 29752-29757 DT denotes these
T15612 29758-29760 NN denotes Th
T15613 29761-29765 NN denotes cell
T15614 29766-29773 NN denotes subsets
T15615 29775-29779 IN denotes With
T15616 29780-29786 NN denotes regard
T15617 29787-29789 TO denotes to
T15618 29790-29793 DT denotes the
T15619 29794-29804 NN denotes expression
T15620 29805-29807 IN denotes of
T15621 29808-29813 NN denotes IL-10
T15622 29814-29816 IN denotes by
T15623 29817-29820 NN denotes Th1
T15624 29821-29826 NN denotes cells
T15625 29826-29827 -COMMA- denotes ,
T15626 29828-29831 PRP-DOLLAR- denotes our
T15627 29832-29836 NN denotes data
T15628 29837-29844 VB denotes provide
T15629 29845-29846 DT denotes a
T15630 29847-29856 NN denotes mechanism
T15631 29857-29860 IN denotes for
T15632 29861-29864 WRB denotes how
T15633 29865-29870 NN denotes IL-10
T15634 29871-29881 NN denotes expression
T15635 29882-29884 VB denotes is
T15636 29885-29892 VB denotes induced
T15637 29893-29896 CC denotes and
T15638 29897-29901 RB denotes then
T15639 29902-29911 VB denotes amplified
T15640 29912-29915 CC denotes and
T15641 29916-29925 VB denotes regulated
T15642 29926-29928 IN denotes by
T15643 29929-29932 DT denotes the
T15644 29933-29939 NN denotes levels
T15645 29940-29942 IN denotes of
T15646 29943-29950 NN denotes antigen
T15647 29951-29954 CC denotes and
T15648 29955-29960 NN denotes IL-12
T15649 29961-29972 VB denotes encountered
T15650 29973-29975 IN denotes in
T15651 29976-29979 DT denotes the
T15652 29980-29991 NN denotes environment
T15653 29993-29997 DT denotes This
T15654 29998-30006 VB denotes provides
T15655 30007-30008 DT denotes a
T15656 30009-30018 NN denotes mechanism
T15657 30019-30026 WRB denotes whereby
T15658 30027-30028 DT denotes a
T15659 30029-30032 NN denotes Th1
T15660 30033-30037 NN denotes cell
T15661 30038-30046 VB denotes responds
T15662 30047-30049 TO denotes to
T15663 30050-30059 JJ denotes extrinsic
T15664 30060-30067 NN denotes signals
T15665 30067-30068 -COMMA- denotes ,
T15666 30069-30079 VB denotes reflecting
T15667 30080-30089 VB denotes increased
T15668 30090-30102 NN denotes inflammation
T15669 30103-30105 IN denotes in
T15670 30106-30109 DT denotes the
T15671 30110-30116 NN denotes tissue
T15672 30116-30117 -COMMA- denotes ,
T15673 30118-30120 TO denotes to
T15674 30121-30128 RB denotes tightly
T15675 30129-30137 VB denotes regulate
T15676 30138-30141 DT denotes the
T15677 30142-30152 NN denotes production
T15678 30153-30155 IN denotes of
T15679 30156-30161 NN denotes IL-10
T15680 30162-30164 RB denotes so
T15681 30165-30167 IN denotes as
T15682 30168-30170 TO denotes to
T15683 30171-30176 VB denotes allow
T15684 30177-30178 DT denotes a
T15685 30179-30189 JJ denotes protective
T15686 30190-30198 NN denotes response
T15687 30199-30201 TO denotes to
T15688 30202-30211 VB denotes eradicate
T15689 30212-30213 DT denotes a
T15690 30214-30222 NN denotes pathogen
T15691 30223-30227 IN denotes with
T15692 30228-30235 JJ denotes minimal
T15693 30236-30242 NN denotes damage
T15694 30243-30245 TO denotes to
T15695 30246-30249 DT denotes the
T15696 30250-30254 NN denotes host
T15697 30255-30258 CC denotes and
T15698 30259-30263 RB denotes also
T15699 30264-30271 VB denotes prevent
T15700 30272-30279 JJ denotes chronic
T15701 30280-30289 NN denotes infection
T15702 30291-30299 RB denotes Moreover
T15703 30299-30300 -COMMA- denotes ,
T15704 30301-30304 PRP-DOLLAR- denotes our
T15705 30305-30313 NN denotes findings
T15706 30314-30318 VB denotes have
T15707 30319-30328 JJ denotes important
T15708 30329-30341 NN denotes implications
T15709 30342-30345 IN denotes for
T15710 30346-30349 DT denotes the
T15711 30350-30360 NN denotes regulation
T15712 30361-30363 IN denotes of
T15713 30364-30369 NN denotes IL-10
T15714 30370-30380 NN denotes production
T15715 30381-30387 IN denotes during
T15716 30388-30390 DT denotes an
T15717 30391-30403 JJ denotes inflammatory
T15718 30404-30407 NN denotes Th1
T15719 30408-30416 NN denotes response
T15720 30417-30419 IN denotes in
T15721 30420-30429 NN denotes infection
T15722 30430-30433 CC denotes and
T15723 30434-30437 MD denotes may
T15724 30438-30440 VB denotes be
T15725 30441-30443 IN denotes of
T15726 30444-30453 NN denotes relevance
T15727 30454-30457 IN denotes for
T15728 30458-30461 DT denotes the
T15729 30462-30468 NN denotes design
T15730 30469-30471 IN denotes of
T15731 30472-30480 NN denotes vaccines
T15732 30481-30484 CC denotes and
T15733 30485-30488 IN denotes for
T15734 30489-30499 NN denotes strategies
T15735 30500-30502 IN denotes in
T15736 30503-30516 NN denotes immunotherapy
T15737 30517-30519 IN denotes in
T15738 30520-30530 JJ denotes infectious
T15739 30531-30539 NN denotes diseases
T19140 31805-31814 NN denotes Isolation
T19141 31815-31817 IN denotes of
T19142 31818-31822 JJ denotes CD4+
T19143 31823-31824 NN denotes T
T19144 31825-31830 NN denotes Cells
T19145 31831-31834 CC denotes and
T19146 31835-31837 IN denotes of
T19147 31838-31845 JJ denotes Splenic
T19148 31846-31848 NN denotes DC
T19149 31849-31852 CC denotes and
T19150 31853-31857 NNP denotes Cell
T19151 31858-31865 NN denotes Culture
T19152 31866-31869 IN denotes for
T19153 31870-31871 NN denotes T
T19154 31872-31876 NN denotes Cell
T19155 31877-31886 NN denotes Phenotype
T19156 31887-31902 NN denotes Differentiation
T19157 31903-31904 NN denotes T
T19158 31905-31910 NN denotes cells
T19159 31911-31915 VB denotes were
T19160 31916-31922 VB denotes sorted
T19161 31923-31926 IN denotes for
T19162 31927-31938 NN denotes CD4+CD62Lhi
T19163 31938-31939 -COMMA- denotes ,
T19164 31940-31956 NN denotes CD4+CD62LhiCD25−
T19165 31956-31957 -COMMA- denotes ,
T19166 31958-31960 CC denotes or
T19167 31961-31976 NN denotes CD4+CD44loCD25−
T19168 31977-31979 TO denotes to
T19169 31980-31981 SYM denotes >
T19170 31981-31983 CD denotes 98
T19171 31983-31984 NN denotes %
T19172 31985-31987 IN denotes on
T19173 31988-31989 DT denotes a
T19174 31990-31995 NNP denotes Moflo
T19175 31996-32005 NN denotes cytometer
T19176 32006-32007 -LRB- denotes (
T19177 32007-32017 NN denotes Cytomation
T19178 32017-32018 -RRB- denotes )
T19179 32019-32021 IN denotes as
T19180 32022-32028 IN denotes before
T19181 32029-32030 -LRB- denotes (
T19182 32030-32039 NNP denotes Shoemaker
T19183 32040-32046 NNP denotes et al.
T19184 32046-32047 -COMMA- denotes ,
T19185 32048-32052 CD denotes 2006
T19186 32052-32053 -COLON- denotes ;
T19187 32054-32062 NNP denotes Veldhoen
T19188 32063-32069 FW denotes et al.
T19189 32069-32070 -COMMA- denotes ,
T19190 32071-32075 CD denotes 2009
T19191 32075-32076 -RRB- denotes )
T19192 32078-32080 IN denotes In
T19193 32081-32085 JJ denotes most
T19194 32086-32091 NN denotes cases
T19195 32091-32092 -COMMA- denotes ,
T19196 32093-32104 NN denotes experiments
T19197 32105-32109 VB denotes were
T19198 32110-32120 VB denotes reproduced
T19199 32121-32125 IN denotes with
T19200 32126-32130 DT denotes each
T19201 32131-32135 NN denotes type
T19202 32136-32138 IN denotes of
T19203 32139-32147 VB denotes purified
T19204 32148-32152 JJ denotes CD4+
T19205 32153-32159 NN denotes T cell
T19206 32160-32170 NN denotes population
T19207 32171-32175 IN denotes with
T19208 32176-32183 JJ denotes similar
T19209 32184-32191 NN denotes results
T19210 32192-32200 VB denotes obtained
T19211 32202-32209 JJ denotes Splenic
T19212 32210-32213 NN denotes DCs
T19213 32214-32218 VB denotes were
T19214 32219-32227 VB denotes prepared
T19215 32228-32230 IN denotes as
T19216 32231-32240 VB denotes described
T19217 32241-32242 -LRB- denotes (
T19218 32242-32248 NNP denotes Hosken
T19219 32249-32255 NNP denotes et al.
T19220 32255-32256 -COMMA- denotes ,
T19221 32257-32261 CD denotes 1995
T19222 32261-32262 -RRB- denotes )
T19223 32262-32263 -COMMA- denotes ,
T19224 32264-32267 CC denotes and
T19225 32268-32272 NN denotes sort
T19226 32273-32281 VB denotes purified
T19227 32282-32288 JJ denotes CD11c+
T19228 32289-32294 NN denotes cells
T19229 32295-32299 VB denotes were
T19230 32300-32305 VB denotes added
T19231 32306-32308 TO denotes to
T19232 32309-32312 DT denotes the
T19233 32313-32319 NN denotes T cell
T19234 32320-32327 NN denotes culture
T19235 32329-32337 VB denotes Purified
T19236 32338-32345 NN denotes DO11.10
T19237 32346-32350 JJ denotes CD4+
T19238 32351-32358 NN denotes T cells
T19239 32359-32360 -LRB- denotes (
T19240 32360-32361 CD denotes 1
T19241 32362-32363 IN denotes ×
T19242 32364-32367 CD denotes 105
T19243 32368-32376 NN denotes cells/ml
T19244 32376-32377 -RRB- denotes )
T19245 32378-32382 VB denotes were
T19246 32383-32391 VB denotes cultured
T19247 32392-32394 IN denotes as
T19248 32395-32401 IN denotes before
T19249 32402-32403 -LRB- denotes (
T19250 32403-32409 NNP denotes Hosken
T19251 32410-32416 NNP denotes et al.
T19252 32416-32417 -COMMA- denotes ,
T19253 32418-32422 CD denotes 1995
T19254 32422-32423 -RRB- denotes )
T19255 32423-32424 -COMMA- denotes ,
T19256 32425-32427 IN denotes in
T19257 32428-32429 DT denotes a
T19258 32430-32435 JJ denotes total
T19259 32436-32442 NN denotes volume
T19260 32443-32445 IN denotes of
T19261 32446-32447 CD denotes 1
T19262 32448-32450 NN denotes ml
T19263 32451-32456 NN denotes cRPMI
T19264 32457-32463 NN denotes medium
T19265 32464-32466 IN denotes in
T19266 32467-32468 DT denotes a
T19267 32469-32476 JJ denotes 48-well
T19268 32477-32482 NN denotes plate
T19269 32482-32483 -COMMA- denotes ,
T19270 32484-32488 IN denotes with
T19271 32489-32496 JJ denotes splenic
T19272 32497-32500 NN denotes DCs
T19273 32501-32502 -LRB- denotes (
T19274 32502-32503 CD denotes 2
T19275 32504-32505 CC denotes ×
T19276 32506-32509 CD denotes 104
T19277 32510-32518 NN denotes cells/ml
T19278 32518-32519 -RRB- denotes )
T19279 32519-32520 -COMMA- denotes ,
T19280 32521-32524 CC denotes and
T19281 32525-32532 VB denotes varying
T19282 32533-32540 NN denotes amounts
T19283 32541-32543 IN denotes of
T19284 32544-32547 NN denotes OVA
T19285 32548-32551 CC denotes and
T19286 32552-32554 IN denotes of
T19287 32555-32560 NN denotes IL-12
T19288 32562-32577 JJ denotes APC-independent
T19289 32578-32593 NN denotes differentiation
T19290 32594-32596 IN denotes of
T19291 32597-32602 JJ denotes naive
T19292 32603-32607 JJ denotes CD4+
T19293 32608-32615 NN denotes T cells
T19294 32616-32620 IN denotes into
T19295 32621-32624 NN denotes Th1
T19296 32625-32628 CC denotes and
T19297 32629-32632 NN denotes Th2
T19298 32633-32638 NN denotes cells
T19299 32639-32643 VB denotes used
T19300 32644-32655 NN denotes stimulation
T19301 32656-32660 IN denotes with
T19302 32661-32669 JJ denotes anti-CD3
T19303 32670-32673 CC denotes and
T19304 32674-32683 JJ denotes anti-CD28
T19305 32684-32687 CC denotes and
T19306 32688-32699 JJ denotes appropriate
T19307 32700-32708 NN denotes cytokine
T19308 32709-32719 NN denotes conditions
T19309 32719-32720 -COMMA- denotes ,
T19310 32721-32724 CC denotes and
T19311 32725-32732 NN denotes control
T19312 32733-32736 NN denotes Th1
T19313 32737-32740 CC denotes and
T19314 32741-32744 NN denotes Th2
T19315 32745-32750 NN denotes cells
T19316 32751-32755 VB denotes were
T19317 32756-32764 VB denotes cultured
T19318 32765-32767 IN denotes as
T19319 32768-32777 VB denotes described
T19320 32778-32784 IN denotes before
T19321 32785-32786 -LRB- denotes (
T19322 32786-32792 NNP denotes Hosken
T19323 32793-32799 NNP denotes et al.
T19324 32799-32800 -COMMA- denotes ,
T19325 32801-32805 CD denotes 1995
T19326 32805-32806 -COLON- denotes ;
T19327 32807-32816 NNP denotes Shoemaker
T19328 32817-32823 FW denotes et al.
T19329 32823-32824 -COMMA- denotes ,
T19330 32825-32829 CD denotes 2006
T19331 32829-32830 -RRB- denotes )
T19332 32832-32839 NN denotes Culture
T19333 32840-32850 NN denotes conditions
T19334 32851-32854 IN denotes for
T19335 32855-32859 NN denotes Th17
T19336 32860-32865 NN denotes cells
T19337 32866-32870 VB denotes were
T19338 32871-32873 IN denotes as
T19339 32874-32883 VB denotes described
T19340 32884-32890 IN denotes before
T19341 32891-32892 -LRB- denotes (
T19342 32892-32900 NNP denotes Veldhoen
T19343 32901-32907 NNP denotes et al.
T19344 32907-32908 -COMMA- denotes ,
T19345 32909-32913 CD denotes 2006
T19346 32913-32914 -RRB- denotes )
T19347 32916-32927 RB denotes Importantly
T19348 32927-32928 -COMMA- denotes ,
T19349 32929-32932 NN denotes Th1
T19350 32933-32936 CC denotes and
T19351 32937-32940 NN denotes Th2
T19352 32941-32946 NN denotes cells
T19353 32947-32952 MD denotes could
T19354 32953-32955 VB denotes be
T19355 32956-32970 VB denotes differentiated
T19356 32971-32973 IN denotes in
T19357 32974-32979 NN denotes cRPMI
T19358 32980-32982 CC denotes or
T19359 32983-32987 NN denotes IMDM
T19360 32988-32989 -LRB- denotes (
T19361 32989-32995 NNP denotes Hosken
T19362 32996-33002 NNP denotes et al.
T19363 33002-33003 -COMMA- denotes ,
T19364 33004-33008 CD denotes 1995
T19365 33008-33009 -COLON- denotes ;
T19366 33010-33019 NNP denotes Shoemaker
T19367 33020-33026 FW denotes et al.
T19368 33026-33027 -COMMA- denotes ,
T19369 33028-33032 CD denotes 2006
T19370 33032-33033 -COLON- denotes ;
T19371 33034-33042 NNP denotes Veldhoen
T19372 33043-33049 FW denotes et al.
T19373 33049-33050 -COMMA- denotes ,
T19374 33051-33055 CD denotes 2006
T19375 33055-33056 -RRB- denotes )
T19376 33056-33057 -COMMA- denotes ,
T19377 33058-33061 CC denotes but
T19378 33062-33066 NN denotes Th17
T19379 33067-33072 NN denotes cells
T19380 33073-33077 VB denotes were
T19381 33078-33082 RB denotes only
T19382 33083-33097 VB denotes differentiated
T19383 33098-33107 RB denotes optimally
T19384 33108-33110 IN denotes in
T19385 33111-33115 NNP denotes IMDM
T19386 33116-33117 -LRB- denotes (
T19387 33117-33125 NNP denotes Veldhoen
T19388 33126-33132 NNP denotes et al.
T19389 33132-33133 -COMMA- denotes ,
T19390 33134-33138 CD denotes 2009
T19391 33138-33139 -RRB- denotes )
T19392 33141-33145 WRB denotes When
T19393 33146-33155 VB denotes indicated
T19394 33155-33156 -COMMA- denotes ,
T19395 33157-33162 NN denotes U0126
T19396 33163-33165 CC denotes or
T19397 33166-33174 NN denotes PD184352
T19398 33175-33176 -LRB- denotes (
T19399 33176-33179 NN denotes MEK
T19400 33180-33190 NN denotes inhibitors
T19401 33190-33191 -RRB- denotes )
T19402 33191-33192 -COMMA- denotes ,
T19403 33193-33201 NN denotes SB203580
T19404 33202-33203 -LRB- denotes (
T19405 33203-33206 NN denotes p38
T19406 33207-33216 NN denotes inhibitor
T19407 33216-33217 -RRB- denotes )
T19408 33217-33218 -COMMA- denotes ,
T19409 33219-33226 NN denotes CT99021
T19410 33227-33228 -LRB- denotes (
T19411 33228-33233 NN denotes GSK3β
T19412 33234-33243 NN denotes inhibitor
T19413 33243-33244 -RRB- denotes )
T19414 33244-33245 -COMMA- denotes ,
T19415 33246-33248 CC denotes or
T19416 33249-33250 DT denotes a
T19417 33251-33258 JJ denotes similar
T19418 33259-33265 NN denotes amount
T19419 33266-33268 IN denotes of
T19420 33269-33273 NN denotes DMSO
T19421 33274-33278 VB denotes were
T19422 33279-33286 JJ denotes present
T19423 33287-33289 IN denotes in
T19424 33290-33293 DT denotes the
T19425 33294-33301 NN denotes culture
T19426 33303-33307 JJ denotes More
T19427 33308-33315 NN denotes details
T19428 33316-33318 IN denotes of
T19429 33319-33327 JJ denotes specific
T19430 33328-33335 NN denotes culture
T19431 33336-33346 NN denotes conditions
T19432 33347-33350 VB denotes are
T19433 33351-33359 VB denotes provided
T19434 33360-33362 IN denotes in
T19435 33363-33370 NN denotes Figures
T19436 33371-33373 NN denotes S6
T19437 33374-33377 CC denotes and
T19438 33378-33380 NN denotes S7
T19943 33383-33391 NN denotes Cytokine
T19944 33392-33401 NN denotes Detection
T19945 33402-33404 IN denotes by
T19946 33405-33408 NN denotes ICS
T19947 33409-33412 CC denotes and
T19948 33413-33418 NN denotes ELISA
T19949 33419-33421 IN denotes At
T19950 33422-33425 NN denotes day
T19951 33426-33427 CD denotes 5
T19952 33428-33430 CC denotes or
T19953 33431-33432 CD denotes 7
T19954 33432-33433 -COMMA- denotes ,
T19955 33434-33439 NN denotes cells
T19956 33440-33444 VB denotes were
T19957 33445-33457 VB denotes restimulated
T19958 33458-33462 IN denotes with
T19959 33463-33474 VB denotes immobilized
T19960 33475-33483 NN denotes anti-CD3
T19961 33484-33485 -LRB- denotes (
T19962 33485-33486 CD denotes 2
T19963 33487-33492 NN denotes μg/ml
T19964 33492-33493 -RRB- denotes )
T19965 33494-33497 CC denotes and
T19966 33498-33507 JJ denotes anti-CD28
T19967 33508-33509 -LRB- denotes (
T19968 33509-33510 CD denotes 2
T19969 33511-33516 NN denotes μg/ml
T19970 33516-33517 -RRB- denotes )
T19971 33518-33519 -LRB- denotes (
T19972 33519-33520 CD denotes 4
T19973 33521-33523 NN denotes hr
T19974 33524-33528 IN denotes with
T19975 33529-33539 NNP denotes BrefeldinA
T19976 33540-33541 -LRB- denotes [
T19977 33541-33543 CD denotes 10
T19978 33544-33549 NN denotes μg/ml
T19979 33549-33550 -RRB- denotes ]
T19980 33551-33553 IN denotes in
T19981 33554-33557 DT denotes the
T19982 33558-33562 JJ denotes last
T19983 33563-33564 CD denotes 2
T19984 33565-33567 NN denotes hr
T19985 33567-33568 -RRB- denotes )
T19986 33569-33571 CC denotes or
T19987 33572-33576 IN denotes with
T19988 33577-33581 NN denotes PdBU
T19989 33582-33585 CC denotes and
T19990 33586-33595 NN denotes Ionomycin
T19991 33596-33597 -LRB- denotes (
T19992 33597-33598 CD denotes 5
T19993 33599-33601 NN denotes hr
T19994 33602-33606 IN denotes with
T19995 33607-33617 NNP denotes BrefeldinA
T19996 33618-33619 -LRB- denotes [
T19997 33619-33620 CD denotes 1
T19998 33621-33626 NN denotes μg/ml
T19999 33626-33627 -RRB- denotes ]
T20000 33627-33628 -RRB- denotes )
T20001 33630-33635 IN denotes After
T20002 33636-33639 NNP denotes ICS
T20003 33640-33644 NNP denotes FACS
T20004 33644-33645 -COMMA- denotes ,
T20005 33646-33650 NN denotes data
T20006 33651-33655 VB denotes were
T20007 33656-33665 VB denotes collected
T20008 33666-33668 IN denotes on
T20009 33669-33670 DT denotes a
T20010 33671-33682 NNP denotes FACSCalibur
T20011 33683-33684 -LRB- denotes (
T20012 33684-33690 NNP denotes Becton
T20013 33691-33700 NNP denotes Dickinson
T20014 33700-33701 -RRB- denotes )
T20015 33702-33705 CC denotes and
T20016 33706-33714 VB denotes analyzed
T20017 33715-33719 IN denotes with
T20018 33720-33726 NNP denotes FlowJo
T20019 33727-33728 -LRB- denotes (
T20020 33728-33732 NNP denotes Tree
T20021 33733-33737 NNP denotes Star
T20022 33737-33738 -RRB- denotes )
T20023 33740-33743 IN denotes For
T20024 33744-33749 NN denotes ELISA
T20025 33749-33750 -COMMA- denotes ,
T20026 33751-33756 NN denotes cells
T20027 33757-33761 VB denotes were
T20028 33762-33771 RB denotes similarly
T20029 33772-33784 VB denotes restimulated
T20030 33785-33788 IN denotes for
T20031 33789-33791 CD denotes 48
T20032 33792-33794 NN denotes hr
T20033 33795-33798 CC denotes and
T20034 33799-33810 NN denotes supernatant
T20035 33811-33814 VB denotes was
T20036 33815-33824 VB denotes collected
T20037 33825-33828 CC denotes and
T20038 33829-33837 VB denotes analyzed
T20039 33838-33841 IN denotes for
T20040 33842-33846 NN denotes IL-4
T20041 33846-33847 -COMMA- denotes ,
T20042 33848-33853 NN denotes IL-10
T20043 33853-33854 -COMMA- denotes ,
T20044 33855-33858 CC denotes and
T20045 33859-33864 NN denotes IFN-γ
T20046 33865-33867 IN denotes as
T20047 33868-33877 VB denotes described
T20048 33878-33884 IN denotes before
T20049 33885-33886 -LRB- denotes (
T20050 33886-33895 NNP denotes Shoemaker
T20051 33896-33902 NNP denotes et al.
T20052 33902-33903 -COMMA- denotes ,
T20053 33904-33908 CD denotes 2006
T20054 33908-33909 -RRB- denotes )
T20251 33912-33914 IN denotes In
T20252 33915-33919 NNP denotes Vivo
T20253 33920-33927 NN denotes Studies
T20254 33928-33934 NN denotes BALB/c
T20255 33935-33939 NN denotes mice
T20256 33940-33944 VB denotes were
T20257 33945-33953 VB denotes injected
T20258 33954-33967 RB denotes intravenously
T20259 33968-33969 -LRB- denotes (
T20260 33969-33973 RB denotes i.v.
T20261 33973-33974 -RRB- denotes )
T20262 33975-33979 IN denotes with
T20263 33980-33981 DT denotes a
T20264 33982-33985 JJ denotes red
T20265 33986-33991 NN denotes blood
T20266 33992-34005 JJ denotes cell-depleted
T20267 34006-34017 JJ denotes single-cell
T20268 34018-34024 NN denotes spleen
T20269 34025-34035 NN denotes suspension
T20270 34036-34037 -LRB- denotes (
T20271 34037-34040 CD denotes 2.5
T20272 34041-34042 CC denotes ×
T20273 34043-34046 CD denotes 107
T20274 34047-34052 NN denotes cells
T20275 34052-34053 -RRB- denotes )
T20276 34054-34055 -LRB- denotes (
T20277 34055-34061 NNP denotes Castro
T20278 34062-34068 NNP denotes et al.
T20279 34068-34069 -COMMA- denotes ,
T20280 34070-34074 CD denotes 2000
T20281 34074-34075 -RRB- denotes )
T20282 34076-34080 IN denotes from
T20283 34081-34088 NN denotes DO11.10
T20284 34089-34091 NN denotes WT
T20285 34092-34094 CC denotes or
T20286 34095-34109 JJ denotes STAT-deficient
T20287 34110-34114 NN denotes mice
T20288 34116-34121 IN denotes After
T20289 34122-34124 CD denotes 48
T20290 34125-34127 NN denotes hr
T20291 34127-34128 -COMMA- denotes ,
T20292 34129-34133 PRP denotes they
T20293 34134-34138 VB denotes were
T20294 34139-34147 VB denotes injected
T20295 34148-34162 RB denotes subcutaneously
T20296 34163-34167 IN denotes with
T20297 34168-34171 NN denotes PBS
T20298 34172-34174 CC denotes or
T20299 34175-34179 IN denotes with
T20300 34180-34183 NN denotes OVA
T20301 34184-34191 NN denotes protein
T20302 34192-34193 -LRB- denotes (
T20303 34193-34194 CD denotes 5
T20304 34195-34197 NN denotes mg
T20305 34197-34198 -RRB- denotes )
T20306 34199-34203 CC denotes plus
T20307 34204-34207 NN denotes LPS
T20308 34208-34209 -LRB- denotes (
T20309 34209-34210 CD denotes 5
T20310 34211-34213 NN denotes μg
T20311 34213-34214 -RRB- denotes )
T20312 34216-34219 DT denotes The
T20313 34220-34228 JJ denotes inguinal
T20314 34229-34234 NN denotes lymph
T20315 34235-34240 NN denotes nodes
T20316 34241-34245 VB denotes were
T20317 34246-34253 VB denotes removed
T20318 34254-34256 CD denotes 48
T20319 34257-34259 NN denotes hr
T20320 34260-34265 RB denotes later
T20321 34267-34268 DT denotes A
T20322 34269-34280 JJ denotes single-cell
T20323 34281-34291 NN denotes suspension
T20324 34292-34293 -LRB- denotes (
T20325 34293-34294 CD denotes 1
T20326 34295-34296 NN denotes ×
T20327 34297-34300 CD denotes 106
T20328 34301-34306 NN denotes cells
T20329 34306-34307 -RRB- denotes )
T20330 34308-34311 VB denotes was
T20331 34312-34324 VB denotes restimulated
T20332 34325-34328 IN denotes for
T20333 34329-34331 CD denotes 24
T20334 34332-34334 CC denotes or
T20335 34335-34337 CD denotes 48
T20336 34338-34340 NN denotes hr
T20337 34341-34345 IN denotes with
T20338 34346-34347 CD denotes 1
T20339 34348-34350 NN denotes μM
T20340 34351-34353 CC denotes or
T20341 34354-34355 CD denotes 3
T20342 34356-34358 NN denotes μM
T20343 34359-34361 IN denotes of
T20344 34362-34365 NN denotes OVA
T20345 34366-34369 CC denotes and
T20346 34370-34374 IN denotes with
T20347 34375-34385 NNP denotes BrefeldinA
T20348 34386-34389 IN denotes for
T20349 34390-34393 DT denotes the
T20350 34394-34398 JJ denotes last
T20351 34399-34400 CD denotes 6
T20352 34401-34403 NN denotes hr
T20353 34405-34409 NN denotes Half
T20354 34410-34412 IN denotes of
T20355 34413-34416 DT denotes the
T20356 34417-34428 NN denotes supernatant
T20357 34429-34432 VB denotes was
T20358 34433-34440 VB denotes removed
T20359 34441-34447 IN denotes before
T20360 34448-34451 DT denotes the
T20361 34452-34460 NN denotes addition
T20362 34461-34463 IN denotes of
T20363 34464-34474 NNP denotes BrefeldinA
T20364 34475-34478 IN denotes for
T20365 34479-34482 NN denotes use
T20366 34483-34485 IN denotes in
T20367 34486-34488 DT denotes an
T20368 34489-34494 NN denotes ELISA
T20369 34495-34500 NN denotes assay
T20370 34502-34505 DT denotes The
T20371 34506-34511 NN denotes cells
T20372 34512-34516 VB denotes were
T20373 34517-34522 VB denotes fixed
T20374 34523-34526 CC denotes and
T20375 34527-34534 VB denotes stained
T20376 34535-34537 IN denotes as
T20377 34538-34544 RB denotes before
T20378 34546-34551 DT denotes Those
T20379 34552-34560 JJ denotes positive
T20380 34561-34564 IN denotes for
T20381 34565-34575 NN denotes KJ1-26-Bio
T20382 34576-34579 CC denotes and
T20383 34580-34583 IN denotes for
T20384 34584-34593 NN denotes CD4-PerCP
T20385 34594-34598 VB denotes were
T20386 34599-34604 VB denotes gated
T20387 34604-34605 -COMMA- denotes ,
T20388 34606-34609 CC denotes and
T20389 34610-34615 NN denotes IFN-γ
T20390 34616-34619 CC denotes and
T20391 34620-34625 NN denotes IL-10
T20392 34626-34634 NN denotes staining
T20393 34635-34638 VB denotes was
T20394 34639-34647 VB denotes examined
T20395 34648-34651 IN denotes for
T20396 34652-34656 DT denotes this
T20397 34657-34667 NN denotes population
T20398 34668-34671 CC denotes and
T20399 34672-34680 VB denotes analyzed
T20400 34681-34683 IN denotes as
T20401 34684-34690 RB denotes before
T20634 34693-34702 JJ denotes Real-Time
T20635 34703-34715 JJ denotes Quantitative
T20636 34716-34722 NN denotes RT-PCR
T20637 34723-34728 NN denotes Cells
T20638 34729-34733 VB denotes were
T20639 34734-34743 VB denotes harvested
T20640 34744-34747 CC denotes and
T20641 34748-34760 VB denotes restimulated
T20642 34761-34763 IN denotes in
T20643 34764-34767 DT denotes the
T20644 34768-34776 NN denotes presence
T20645 34777-34779 IN denotes of
T20646 34780-34791 VB denotes immobilized
T20647 34792-34800 NN denotes anti-CD3
T20648 34801-34802 -LRB- denotes (
T20649 34802-34803 CD denotes 2
T20650 34804-34809 NN denotes μg/ml
T20651 34809-34810 -RRB- denotes )
T20652 34811-34815 CC denotes plus
T20653 34816-34825 NN denotes anti-CD28
T20654 34826-34827 -LRB- denotes (
T20655 34827-34828 CD denotes 2
T20656 34829-34834 NN denotes μg/ml
T20657 34834-34835 -RRB- denotes )
T20658 34836-34839 IN denotes for
T20659 34840-34841 CD denotes 3
T20660 34842-34844 NN denotes hr
T20661 34845-34847 CC denotes or
T20662 34848-34859 RB denotes immediately
T20663 34860-34865 VB denotes lysed
T20664 34867-34870 NN denotes RNA
T20665 34871-34874 VB denotes was
T20666 34875-34884 VB denotes extracted
T20667 34885-34888 CC denotes and
T20668 34889-34908 JJ denotes reverse-transcribed
T20669 34909-34912 CC denotes and
T20670 34913-34917 NN denotes cDNA
T20671 34918-34921 VB denotes was
T20672 34922-34930 VB denotes analyzed
T20673 34931-34934 IN denotes for
T20674 34935-34938 DT denotes the
T20675 34939-34949 NN denotes expression
T20676 34950-34952 IN denotes of
T20677 34953-34962 NN denotes cytokines
T20678 34963-34966 CC denotes and
T20679 34967-34980 NN denotes transcription
T20680 34981-34988 NN denotes factors
T20681 34989-34991 IN denotes by
T20682 34992-35001 JJ denotes real-time
T20683 35002-35005 NN denotes PCR
T20684 35006-35011 NN denotes assay
T20685 35012-35014 IN denotes as
T20686 35015-35021 IN denotes before
T20687 35022-35023 -LRB- denotes (
T20688 35023-35032 NNP denotes Shoemaker
T20689 35033-35039 NNP denotes et al.
T20690 35039-35040 -COMMA- denotes ,
T20691 35041-35045 CD denotes 2006
T20692 35045-35046 -RRB- denotes )
T20693 35048-35054 NN denotes Target
T20694 35055-35059 NN denotes gene
T20695 35060-35064 NN denotes mRNA
T20696 35065-35075 NN denotes expression
T20697 35076-35079 VB denotes was
T20698 35080-35090 VB denotes quantified
T20699 35091-35097 CC denotes either
T20700 35098-35102 IN denotes with
T20701 35103-35107 NN denotes SYBR
T20702 35108-35113 NNP denotes Green
T20703 35114-35115 -LRB- denotes (
T20704 35115-35122 NNP denotes Applied
T20705 35123-35133 NNP denotes Biosystems
T20706 35133-35134 -RRB- denotes )
T20707 35135-35137 CC denotes or
T20708 35138-35142 IN denotes with
T20709 35143-35149 NNP denotes Master
T20710 35150-35153 NNP denotes Mix
T20711 35154-35155 -LRB- denotes (
T20712 35155-35162 NNP denotes Applied
T20713 35163-35173 NNP denotes Biosystems
T20714 35173-35174 -RRB- denotes )
T20715 35175-35178 CC denotes and
T20716 35179-35189 VB denotes normalized
T20717 35190-35192 TO denotes to
T20718 35193-35202 NN denotes ubiquitin
T20719 35203-35205 CC denotes or
T20720 35206-35210 NN denotes HPRT
T20721 35211-35215 NN denotes mRNA
T20722 35216-35222 NN denotes levels
T20723 35222-35223 -COMMA- denotes ,
T20724 35224-35236 RB denotes respectively
T20871 35239-35253 NN denotes Immunoblotting
T20872 35254-35268 VB denotes Differentiated
T20873 35269-35273 JJ denotes CD4+
T20874 35274-35281 NN denotes T cells
T20875 35282-35286 VB denotes were
T20876 35287-35293 VB denotes rested
T20877 35294-35297 IN denotes for
T20878 35298-35299 CD denotes 5
T20879 35300-35302 NN denotes hr
T20880 35303-35305 IN denotes in
T20881 35306-35307 CD denotes 1
T20882 35307-35308 NN denotes %
T20883 35309-35323 JJ denotes FCS-containing
T20884 35324-35330 NN denotes medium
T20885 35331-35334 CC denotes and
T20886 35335-35347 VB denotes restimulated
T20887 35348-35350 IN denotes as
T20888 35351-35360 VB denotes described
T20889 35361-35364 IN denotes for
T20890 35365-35373 JJ denotes specific
T20891 35374-35385 NN denotes experiments
T20892 35387-35391 NN denotes Cell
T20893 35392-35399 NN denotes lysates
T20894 35400-35404 VB denotes were
T20895 35405-35413 VB denotes prepared
T20896 35413-35414 -COMMA- denotes ,
T20897 35415-35420 JJ denotes equal
T20898 35421-35428 NN denotes amounts
T20899 35429-35431 IN denotes of
T20900 35432-35439 NN denotes protein
T20901 35440-35444 VB denotes were
T20902 35445-35454 VB denotes separated
T20903 35455-35457 IN denotes by
T20904 35458-35466 NN denotes SDS-PAGE
T20905 35466-35467 -COMMA- denotes ,
T20906 35468-35471 CC denotes and
T20907 35472-35486 VB denotes phosphorylated
T20908 35487-35489 CC denotes or
T20909 35490-35495 JJ denotes total
T20910 35496-35499 NN denotes ERK
T20911 35500-35503 CC denotes and
T20912 35504-35509 NN denotes actin
T20913 35510-35514 VB denotes were
T20914 35515-35523 VB denotes detected
T20915 35524-35526 IN denotes as
T20916 35527-35536 VB denotes described
T20917 35537-35543 IN denotes before
T20918 35544-35545 -LRB- denotes (
T20919 35545-35551 NNP denotes Beinke
T20920 35552-35558 NNP denotes et al.
T20921 35558-35559 -COMMA- denotes ,
T20922 35560-35564 CD denotes 2004
T20923 35564-35565 -RRB- denotes )
R66 T155 T154 arg1Of Production,Interleukin-10
R67 T155 T156 arg1Of Production,by
R68 T155 T159 arg1Of Production,Requires
R69 T158 T156 arg2Of Cells,by
R70 T158 T157 arg1Of Cells,Th1
R71 T163 T160 arg1Of Factor,Interleukin-12-Induced
R72 T163 T161 arg1Of Factor,STAT4
R73 T163 T162 arg1Of Factor,Transcription
R74 T163 T164 arg1Of Factor,and
R75 T164 T159 arg2Of and,Requires
R76 T164 T169 arg1Of and,by
R77 T168 T164 arg2Of Activation,and
R78 T168 T165 arg1Of Activation,ERK
R79 T168 T166 arg1Of Activation,MAP
R80 T168 T167 arg1Of Activation,Kinase
R81 T172 T169 arg2Of Dose,by
R82 T172 T170 arg1Of Dose,High
R83 T172 T171 arg1Of Dose,Antigen
R84 T175 T174 arg1Of T cells,CD4+
R85 T175 T176 arg1Of T cells,producing
R86 T175 T186 arg1Of T cells,are
R87 T175 T187 arg2Of T cells,reported
R88 T177 T178 arg1Of interleukin-10,(
R89 T177 T181 arg1Of interleukin-10,and
R90 T179 T178 arg2Of IL-10,(
R91 T180 T178 arg3Of ),(
R92 T181 T176 arg2Of and,producing
R93 T182 T181 arg2Of interferon-γ,and
R94 T182 T183 arg1Of interferon-γ,(
R95 T184 T183 arg2Of IFN-γ,(
R96 T185 T183 arg3Of ),(
R97 T187 T186 arg2Of reported,are
R98 T187 T188 arg1Of reported,in
R99 T190 T188 arg2Of infections,in
R100 T190 T189 arg1Of infections,chronic
R101 T194 T193 arg1Of signals,the
R102 T194 T195 arg1Of signals,that
R103 T194 T196 arg1Of signals,direct
R104 T194 T208 arg1Of signals,are
R105 T194 T209 arg1Of signals,undefined
R106 T198 T196 arg2Of development,direct
R107 T198 T197 arg1Of development,the
R108 T198 T199 arg1Of development,of
R109 T205 T204 arg2Of Th1,(
R110 T206 T204 arg3Of ),(
R111 T207 T199 arg2Of cells,of
R112 T207 T200 arg1Of cells,IL-10-producing
R113 T207 T201 arg1Of cells,T
R114 T207 T202 arg1Of cells,helper
R115 T207 T203 arg1Of cells,1
R116 T207 T204 arg1Of cells,(
R117 T208 T191 arg1Of are,However
R118 T208 T192 arg1Of are,","
R119 T209 T208 arg2Of undefined,are
R120 T210 T211 arg1Of We,showed
R121 T213 T214 arg1Of development,of
R122 T213 T218 arg1Of development,required
R123 T217 T214 arg2Of cells,of
R124 T217 T215 arg1Of cells,IL-10-producing
R125 T217 T216 arg1Of cells,Th1
R126 T218 T211 arg2Of required,showed
R127 T218 T212 arg1Of required,that
R128 T221 T219 arg1Of receptor,high
R129 T221 T220 arg1Of receptor,T cell
R130 T221 T222 arg1Of receptor,(
R131 T223 T222 arg2Of TCR,(
R132 T224 T222 arg3Of ),(
R133 T225 T221 arg1Of ligation,receptor
R134 T225 T226 arg1Of ligation,","
R135 T226 T229 arg1Of ",",and
R136 T228 T226 arg2Of ERK1,","
R137 T228 T227 arg1Of ERK1,sustained
R138 T229 T235 arg1Of and,and
R139 T233 T229 arg2Of phosphorylation,and
R140 T233 T230 arg1Of phosphorylation,ERK2
R141 T233 T231 arg1Of phosphorylation,MAP
R142 T233 T232 arg1Of phosphorylation,kinases
R143 T235 T218 arg2Of and,required
R144 T235 T234 arg1Of and,","
R145 T240 T235 arg2Of activation,and
R146 T240 T236 arg1Of activation,IL-12-induced
R147 T240 T237 arg1Of activation,STAT4
R148 T240 T238 arg1Of activation,transcription
R149 T240 T239 arg1Of activation,factor
R150 T243 T241 arg2Of triggering,Repeated
R151 T243 T242 arg1Of triggering,TCR
R152 T243 T244 arg1Of triggering,led
R153 T244 T245 arg1Of led,to
R154 T244 T253 arg1Of led,and
R155 T248 T245 arg2Of production,to
R156 T248 T246 arg2Of production,enhanced
R157 T248 T247 arg1Of production,IL-10
R158 T248 T249 arg1Of production,by
R159 T251 T249 arg2Of cells,by
R160 T251 T250 arg1Of cells,Th1
R161 T253 T252 arg1Of and,","
R162 T256 T254 arg1Of action,continued
R163 T256 T255 arg1Of action,IL-12
R164 T256 T257 arg1Of action,and
R165 T257 T261 arg1Of and,were
R166 T257 T262 arg2Of and,required
R167 T260 T257 arg2Of signaling,and
R168 T260 T258 arg1Of signaling,high-dose
R169 T260 T259 arg1Of signaling,TCR
R170 T262 T253 arg2Of required,and
R171 T262 T261 arg2Of required,were
R172 T262 T263 arg1Of required,for
R173 T265 T266 arg1Of development,and
R174 T266 T263 arg2Of and,for
R175 T266 T264 arg1Of and,the
R176 T266 T268 arg1Of and,of
R177 T267 T266 arg2Of maintenance,and
R178 T271 T268 arg2Of cells,of
R179 T271 T269 arg1Of cells,IL-10-producing
R180 T271 T270 arg1Of cells,Th1
R181 T273 T274 arg1Of Th1,","
R182 T274 T277 arg1Of ",",and
R183 T275 T274 arg2Of Th2,","
R184 T277 T276 arg1Of and,","
R185 T278 T277 arg2Of Th17,and
R186 T279 T273 arg1Of cells,Th1
R187 T279 T275 arg1Of cells,Th2
R188 T279 T278 arg1Of cells,Th17
R189 T279 T280 arg1Of cells,require
R190 T280 T272 arg2Of require,Although
R191 T282 T280 arg2Of activation,require
R192 T282 T281 arg1Of activation,the
R193 T282 T283 arg1Of activation,of
R194 T282 T286 arg1Of activation,for
R195 T285 T283 arg2Of STATs,of
R196 T285 T284 arg1Of STATs,distinct
R197 T288 T286 arg2Of differentiation,for
R198 T288 T287 arg1Of differentiation,their
R199 T288 T289 arg1Of differentiation,","
R200 T290 T291 arg1Of activation,of
R201 T290 T293 arg1Of activation,and
R202 T292 T291 arg2Of ERK1,of
R203 T293 T289 arg2Of and,","
R204 T293 T298 arg1Of and,for
R205 T297 T293 arg2Of requirement,and
R206 T297 T294 arg1Of requirement,ERK2
R207 T297 T295 arg1Of requirement,was a
R208 T297 T296 arg1Of requirement,common
R209 T299 T298 arg2Of production,for
R210 T299 T300 arg1Of production,of
R211 T299 T302 arg1Of production,by
R212 T301 T300 arg2Of IL-10,of
R213 T306 T302 arg2Of subsets,by
R214 T306 T303 arg1Of subsets,all
R215 T306 T304 arg1Of subsets,Th
R216 T306 T305 arg1Of subsets,cell
R217 T308 T307 arg1Of expression,IL-10
R218 T308 T310 arg1Of expression,correlated
R219 T310 T309 arg1Of correlated,also
R220 T310 T311 arg1Of correlated,with
R221 T313 T311 arg2Of expression,with
R222 T313 T312 arg1Of expression,c-maf
R223 T315 T314 arg2Of having,Despite
R224 T315 T318 arg1Of having,in
R225 T317 T315 arg2Of functions,having
R226 T317 T316 arg1Of functions,distinct
R227 T319 T318 arg2Of protection,in
R228 T319 T320 arg1Of protection,against
R229 T321 T320 arg2Of pathogens,against
R230 T325 T315 arg1Of cells,having
R231 T325 T323 arg1Of cells,all
R232 T325 T324 arg1Of cells,Th
R233 T325 T326 arg1Of cells,share
R234 T326 T314 arg1Of share,Despite
R235 T326 T322 arg1Of share,","
R236 T329 T326 arg2Of task,share
R237 T329 T327 arg1Of task,the
R238 T329 T328 arg1Of task,important
R239 T329 T330 arg1Of task,of
R240 T331 T330 arg2Of controlling,of
R241 T331 T335 arg1Of controlling,by
R242 T334 T331 arg2Of responses,controlling
R243 T334 T332 arg1Of responses,overexuberant
R244 T334 T333 arg1Of responses,immune
R245 T336 T335 arg2Of means,by
R246 T336 T337 arg1Of means,of
R247 T339 T337 arg2Of production,of
R248 T339 T338 arg1Of production,IL-10
R2199 T2978 T2979 arg1Of IL-12,and
R2200 T2979 T2984 arg1Of and,Induce
R2201 T2981 T2979 arg2Of Doses,and
R2202 T2981 T2980 arg1Of Doses,High
R2203 T2981 T2982 arg1Of Doses,of
R2204 T2983 T2982 arg2Of Antigen,of
R2205 T2986 T2984 arg2Of Development,Induce
R2206 T2986 T2985 arg1Of Development,the
R2207 T2986 T2987 arg1Of Development,of
R2208 T2989 T2987 arg2Of Cells,of
R2209 T2989 T2988 arg1Of Cells,Th1
R2210 T2989 T2990 arg1Of Cells,Producing
R2211 T2991 T2990 arg2Of IL-10,Producing
R2212 T2993 T2992 arg1Of study,To
R2213 T2995 T2993 arg2Of differentiation,study
R2214 T2995 T2994 arg1Of differentiation,the
R2215 T2995 T2996 arg1Of differentiation,of
R2216 T2998 T2996 arg2Of cells,of
R2217 T2998 T2997 arg1Of cells,Th1
R2218 T2998 T2999 arg1Of cells,coproducing
R2219 T3000 T3001 arg1Of IFN-γ,and
R2220 T3001 T2999 arg2Of and,coproducing
R2221 T3002 T3001 arg2Of IL-10,and
R2222 T3004 T2993 arg1Of we,study
R2223 T3004 T3005 arg1Of we,cultured
R2224 T3005 T2992 modOf cultured,To
R2225 T3005 T3003 arg1Of cultured,","
R2226 T3005 T3012 arg1Of cultured,with
R2227 T3009 T3007 arg1Of naive,TCR-transgenic
R2228 T3009 T3008 arg1Of naive,DO11.10
R2229 T3011 T3005 arg2Of T cells,cultured
R2230 T3011 T3006 arg2Of T cells,purified
R2231 T3011 T3009 arg1Of T cells,naive
R2232 T3011 T3010 arg1Of T cells,CD4+
R2233 T3014 T3012 arg2Of DCs,with
R2234 T3014 T3013 arg2Of DCs,purified
R2235 T3014 T3015 arg1Of DCs,as
R2236 T3016 T3017 arg1Of APCs,and
R2237 T3017 T3015 arg2Of and,as
R2238 T3019 T3017 arg2Of doses,and
R2239 T3019 T3018 arg1Of doses,increasing
R2240 T3019 T3020 arg1Of doses,of
R2241 T3022 T3020 arg2Of peptide,of
R2242 T3022 T3021 arg1Of peptide,ovalbumin
R2243 T3022 T3023 arg1Of peptide,323-339
R2244 T3022 T3024 arg1Of peptide,(
R2245 T3025 T3024 arg2Of OVA,(
R2246 T3026 T3024 arg3Of ),(
R2247 T3027 T3028 arg1Of Culture,with
R2248 T3027 T3033 arg1Of Culture,for
R2249 T3027 T3036 arg1Of Culture,gave
R2250 T3030 T3028 arg2Of doses,with
R2251 T3030 T3029 arg1Of doses,high
R2252 T3030 T3031 arg1Of doses,of
R2253 T3032 T3031 arg2Of antigen,of
R2254 T3035 T3033 arg2Of days,for
R2255 T3035 T3034 arg1Of days,7
R2256 T3037 T3036 arg3Of rise,gave
R2257 T3040 T3039 arg1Of cells,Th1
R2258 T3040 T3041 arg1Of cells,expressing
R2259 T3040 T3045 arg1Of cells,(
R2260 T3040 T3057 arg1Of cells,but
R2261 T3041 T3043 arg1Of expressing,upon
R2262 T3042 T3041 arg2Of IFN-γ,expressing
R2263 T3044 T3043 arg2Of restimulation,upon
R2264 T3047 T3045 arg2Of et al.,(
R2265 T3047 T3046 arg1Of et al.,Constant
R2266 T3047 T3048 arg1Of et al.,","
R2267 T3047 T3050 arg1Of et al.,;
R2268 T3049 T3048 arg2Of 1995,","
R2269 T3051 T3050 arg2Of Hosken,;
R2270 T3051 T3052 arg1Of Hosken,et al.
R2271 T3051 T3053 arg1Of Hosken,","
R2272 T3054 T3053 arg2Of 1995,","
R2273 T3055 T3045 arg3Of ),(
R2274 T3057 T3036 arg2Of but,gave
R2275 T3057 T3038 arg2Of but,to
R2276 T3057 T3056 arg1Of but,","
R2277 T3059 T3057 arg2Of IL-10,but
R2278 T3059 T3058 arg1Of IL-10,not
R2279 T3059 T3060 arg1Of IL-10,(
R2280 T3063 T3060 arg2Of online,(
R2281 T3063 T3061 arg1Of online,Figure S1A
R2282 T3063 T3062 arg1Of online,available
R2283 T3064 T3060 arg3Of ),(
R2284 T3065 T3066 arg1Of Culture,with
R2285 T3065 T3074 arg1Of Culture,led
R2286 T3069 T3066 arg2Of doses,with
R2287 T3069 T3067 arg1Of doses,low
R2288 T3069 T3068 arg1Of doses,antigen
R2289 T3069 T3070 arg1Of doses,under
R2290 T3073 T3070 arg2Of conditions,under
R2291 T3073 T3071 arg1Of conditions,the
R2292 T3073 T3072 arg1Of conditions,same
R2293 T3074 T3075 arg1Of led,to
R2294 T3077 T3075 arg2Of differentiation,to
R2295 T3077 T3076 arg1Of differentiation,the
R2296 T3077 T3078 arg1Of differentiation,of
R2297 T3080 T3078 arg2Of cells,of
R2298 T3080 T3079 arg1Of cells,Th2
R2299 T3080 T3081 arg1Of cells,","
R2300 T3080 T3082 arg1Of cells,which
R2301 T3080 T3083 arg1Of cells,expressed
R2302 T3083 T3088 arg1Of expressed,upon
R2303 T3085 T3086 arg1Of IL-4,and
R2304 T3086 T3083 arg2Of and,expressed
R2305 T3086 T3084 arg1Of and,both
R2306 T3087 T3086 arg2Of IL-10,and
R2307 T3089 T3088 arg2Of restimulation,upon
R2308 T3089 T3090 arg1Of restimulation,(
R2309 T3091 T3090 arg2Of Figure S1A,(
R2310 T3092 T3090 arg3Of ),(
R2311 T3093 T3094 arg1Of Culture,of
R2312 T3093 T3098 arg1Of Culture,in
R2313 T3093 T3114 arg1Of Culture,resulted
R2314 T3097 T3094 arg2Of T cells,of
R2315 T3097 T3095 arg1Of T cells,naive
R2316 T3097 T3096 arg1Of T cells,CD4+
R2317 T3101 T3098 arg2Of system,in
R2318 T3101 T3099 arg1Of system,an
R2319 T3101 T3100 arg1Of system,APC-free
R2320 T3101 T3102 arg1Of system,by
R2321 T3103 T3102 arg2Of stimulation,by
R2322 T3103 T3104 arg1Of stimulation,with
R2323 T3105 T3106 arg1Of anti-CD3,and
R2324 T3107 T3106 arg2Of anti-CD28,and
R2325 T3108 T3104 arg2Of antibodies,with
R2326 T3108 T3105 arg1Of antibodies,anti-CD3
R2327 T3108 T3107 arg1Of antibodies,anti-CD28
R2328 T3108 T3109 arg1Of antibodies,in
R2329 T3111 T3109 arg2Of presence,in
R2330 T3111 T3110 arg1Of presence,the
R2331 T3111 T3112 arg1Of presence,of
R2332 T3113 T3112 arg2Of IL-12,of
R2333 T3114 T3115 arg1Of resulted,in
R2334 T3118 T3115 arg2Of cells,in
R2335 T3118 T3116 arg1Of cells,IFN-γ-producing
R2336 T3118 T3117 arg1Of cells,Th1
R2337 T3118 T3122 arg2Of cells,of
R2338 T3118 T3123 arg1Of cells,which
R2339 T3121 T3120 arg1Of proportion,a
R2340 T3121 T3122 arg1Of proportion,of
R2341 T3121 T3124 arg1Of proportion,coproduced
R2342 T3124 T3119 arg1Of coproduced,","
R2343 T3124 T3126 arg1Of coproduced,","
R2344 T3124 T3127 arg1Of coproduced,as
R2345 T3125 T3124 arg2Of IL-10,coproduced
R2346 T3128 T3127 arg2Of did,as
R2347 T3130 T3128 arg1Of cells,did
R2348 T3130 T3129 arg1Of cells,Th2
R2349 T3130 T3131 arg1Of cells,resulting
R2350 T3131 T3132 arg1Of resulting,from
R2351 T3131 T3134 arg1Of resulting,in
R2352 T3133 T3132 arg2Of culture,from
R2353 T3135 T3134 arg2Of IL-4,in
R2354 T3135 T3136 arg1Of IL-4,(
R2355 T3137 T3136 arg2Of Figure S1B,(
R2356 T3138 T3136 arg3Of ),(
R2357 T3140 T3139 arg1Of investigate,To
R2358 T3143 T3142 arg1Of lack,the
R2359 T3143 T3144 arg1Of lack,of
R2360 T3143 T3150 arg1Of lack,resulted
R2361 T3145 T3144 arg2Of IL-10,of
R2362 T3145 T3146 arg2Of IL-10,produced
R2363 T3149 T3146 arg1Of cells,produced
R2364 T3149 T3147 arg2Of cells,by
R2365 T3149 T3148 arg1Of cells,Th1
R2366 T3150 T3140 arg2Of resulted,investigate
R2367 T3150 T3141 arg1Of resulted,whether
R2368 T3150 T3151 arg1Of resulted,from
R2369 T3152 T3153 arg1Of inhibition,of
R2370 T3152 T3158 arg1Of inhibition,and
R2371 T3155 T3153 arg2Of production,of
R2372 T3155 T3154 arg1Of production,IL-10
R2373 T3155 T3156 arg1Of production,by
R2374 T3157 T3156 arg2Of DCs,by
R2375 T3158 T3151 arg2Of and,from
R2376 T3161 T3159 arg1Of dose,high
R2377 T3161 T3160 arg1Of dose,antigen
R2378 T3161 T3162 arg1Of dose,or
R2379 T3162 T3158 arg2Of or,and
R2380 T3165 T3162 arg2Of IL-12,or
R2381 T3165 T3163 arg1Of IL-12,alternatively
R2382 T3165 T3164 arg2Of IL-12,required
R2383 T3167 T3140 arg1Of we,investigate
R2384 T3167 T3168 arg1Of we,cultured
R2385 T3168 T3139 modOf cultured,To
R2386 T3168 T3166 arg1Of cultured,","
R2387 T3171 T3168 arg2Of T cells,cultured
R2388 T3171 T3169 arg1Of T cells,naive
R2389 T3171 T3170 arg1Of T cells,CD4+
R2390 T3171 T3172 arg1Of T cells,with
R2391 T3174 T3172 arg2Of doses,with
R2392 T3174 T3173 arg1Of doses,increasing
R2393 T3174 T3175 arg1Of doses,of
R2394 T3174 T3177 arg2Of doses,presented
R2395 T3176 T3175 arg2Of antigen,of
R2396 T3177 T3180 arg1Of presented,in
R2397 T3179 T3177 arg1Of DC,presented
R2398 T3179 T3178 arg2Of DC,by
R2399 T3182 T3180 arg2Of presence,in
R2400 T3182 T3181 arg1Of presence,the
R2401 T3182 T3183 arg1Of presence,of
R2402 T3184 T3183 arg2Of IL-12,of
R2403 T3187 T3185 arg2Of doses,At
R2404 T3187 T3186 arg1Of doses,low
R2405 T3187 T3188 arg1Of doses,of
R2406 T3189 T3188 arg2Of antigen,of
R2407 T3191 T3192 arg1Of IL-12,abrogated
R2408 T3191 T3199 arg1Of IL-12,induced
R2409 T3192 T3198 arg1Of abrogated,and
R2410 T3194 T3192 arg2Of development,abrogated
R2411 T3194 T3193 arg1Of development,the
R2412 T3194 T3195 arg1Of development,of
R2413 T3197 T3195 arg2Of cells,of
R2414 T3197 T3196 arg1Of cells,Th2
R2415 T3198 T3185 arg1Of and,At
R2416 T3198 T3190 arg1Of and,","
R2417 T3199 T3198 arg2Of induced,and
R2418 T3199 T3209 arg1Of induced,","
R2419 T3199 T3210 modOf induced,suggesting
R2420 T3201 T3200 arg1Of expression,IFN-γ
R2421 T3201 T3202 arg1Of expression,but
R2422 T3202 T3199 arg2Of but,induced
R2423 T3202 T3206 arg1Of but,of
R2424 T3205 T3202 arg2Of levels,but
R2425 T3205 T3203 arg1Of levels,only
R2426 T3205 T3204 arg1Of levels,low
R2427 T3208 T3206 arg2Of expression,of
R2428 T3208 T3207 arg1Of expression,IL-10
R2429 T3212 T3214 arg1Of IL-12,se
R2430 T3212 T3215 arg1Of IL-12,was
R2431 T3212 T3217 arg1Of IL-12,sufficient
R2432 T3214 T3213 arg1Of se,per
R2433 T3215 T3210 arg2Of was,suggesting
R2434 T3215 T3211 arg1Of was,that
R2435 T3215 T3216 arg1Of was,not
R2436 T3215 T3218 modOf was,to
R2437 T3217 T3215 arg2Of sufficient,was
R2438 T3219 T3218 arg1Of induce,to
R2439 T3219 T3223 arg1Of induce,in
R2440 T3222 T3219 arg2Of production,induce
R2441 T3222 T3220 arg1Of production,significant
R2442 T3222 T3221 arg1Of production,IL-10
R2443 T3225 T3223 arg2Of cells,in
R2444 T3225 T3224 arg1Of cells,Th1
R2445 T3225 T3226 arg1Of cells,(
R2446 T3227 T3226 arg2Of Figure 1A,(
R2447 T3228 T3226 arg3Of ),(
R2448 T3234 T3232 arg1Of dose,the
R2449 T3234 T3233 arg1Of dose,antigen
R2450 T3234 T3235 arg1Of dose,was
R2451 T3234 T3236 arg2Of dose,increased
R2452 T3236 T3231 arg2Of increased,as
R2453 T3236 T3235 arg2Of increased,was
R2454 T3239 T3238 arg1Of populations,Th1
R2455 T3239 T3240 arg2Of populations,driven
R2456 T3239 T3244 arg1Of populations,contained
R2457 T3239 T3254 arg1Of populations,produced
R2458 T3240 T3241 arg1Of driven,with
R2459 T3242 T3241 arg2Of IL-12,with
R2460 T3244 T3253 arg1Of contained,and
R2461 T3246 T3244 arg2Of numbers,contained
R2462 T3246 T3245 arg1Of numbers,higher
R2463 T3246 T3247 arg1Of numbers,of
R2464 T3249 T3247 arg2Of cells,of
R2465 T3249 T3248 arg1Of cells,IL-10-producing
R2466 T3249 T3250 arg1Of cells,(
R2467 T3251 T3250 arg2Of Figure 1A,(
R2468 T3252 T3250 arg3Of ),(
R2469 T3253 T3229 arg1Of and,Strikingly
R2470 T3253 T3230 arg1Of and,","
R2471 T3253 T3231 arg1Of and,as
R2472 T3253 T3237 arg1Of and,","
R2473 T3253 T3243 arg1Of and,now
R2474 T3254 T3253 arg2Of produced,and
R2475 T3254 T3258 arg1Of produced,upon
R2476 T3257 T3254 arg2Of protein,produced
R2477 T3257 T3255 arg1Of protein,more
R2478 T3257 T3256 arg1Of protein,IL-10
R2479 T3259 T3258 arg2Of restimulation,upon
R2480 T3259 T3260 arg1Of restimulation,(
R2481 T3262 T3263 arg1Of 1A,and
R2482 T3263 T3260 arg2Of and,(
R2483 T3263 T3261 arg1Of and,Figures
R2484 T3264 T3263 arg2Of 1B,and
R2485 T3265 T3260 arg3Of ),(
R2486 T3269 T3268 arg1Of development,the
R2487 T3269 T3270 arg1Of development,of
R2488 T3269 T3275 arg1Of development,required
R2489 T3272 T3270 arg2Of cells,of
R2490 T3272 T3271 arg1Of cells,Th1
R2491 T3272 T3273 arg1Of cells,producing
R2492 T3274 T3273 arg2Of IL-10,producing
R2493 T3275 T3266 arg1Of required,Thus
R2494 T3275 T3267 arg1Of required,","
R2495 T3277 T3278 arg1Of IL-12,and
R2496 T3278 T3275 arg2Of and,required
R2497 T3278 T3276 arg1Of and,both
R2498 T3280 T3278 arg2Of doses,and
R2499 T3280 T3279 arg1Of doses,high
R2500 T3280 T3281 arg1Of doses,of
R2501 T3282 T3281 arg2Of antigen,of
R2502 T3284 T3283 arg1Of cells,Th1
R2503 T3284 T3285 arg2Of cells,differentiated
R2504 T3285 T3286 modOf differentiated,to
R2505 T3287 T3294 arg1Of produce,and
R2506 T3289 T3287 arg2Of amounts,produce
R2507 T3289 T3288 arg1Of amounts,large
R2508 T3289 T3290 arg1Of amounts,of
R2509 T3291 T3292 arg1Of IL-10,and
R2510 T3292 T3290 arg2Of and,of
R2511 T3293 T3292 arg2Of IFN-γ,and
R2512 T3294 T3286 arg1Of and,to
R2513 T3295 T3294 arg2Of lost,and
R2514 T3296 T3295 arg2Of their capacity,lost
R2515 T3296 T3297 modOf their capacity,to
R2516 T3298 T3297 arg1Of produce,to
R2517 T3299 T3298 arg2Of IL-2,produce
R2518 T3299 T3300 arg1Of IL-2,(
R2519 T3301 T3300 arg2Of Figure 1B,(
R2520 T3302 T3300 arg3Of ),(
R2521 T3305 T3304 arg1Of presence,the
R2522 T3305 T3306 arg1Of presence,of
R2523 T3305 T3308 arg1Of presence,reduced
R2524 T3307 T3306 arg2Of IL-12,of
R2525 T3308 T3314 arg1Of reduced,at
R2526 T3308 T3325 arg1Of reduced,and
R2527 T3310 T3308 arg2Of proliferation,reduced
R2528 T3310 T3309 arg1Of proliferation,the
R2529 T3310 T3311 arg1Of proliferation,of
R2530 T3313 T3311 arg2Of T cells,of
R2531 T3313 T3312 arg1Of T cells,CD4+
R2532 T3319 T3314 arg2Of doses,at
R2533 T3319 T3315 arg1Of doses,both
R2534 T3319 T3316 arg1Of doses,high
R2535 T3319 T3317 arg1Of doses,and low
R2536 T3319 T3318 arg1Of doses,antigen
R2537 T3319 T3320 arg1Of doses,(
R2538 T3322 T3320 arg2Of S1,(
R2539 T3322 T3321 arg1Of S1,Table
R2540 T3323 T3320 arg3Of ),(
R2541 T3325 T3303 arg2Of and,Because
R2542 T3325 T3324 arg1Of and,","
R2543 T3328 T3326 arg1Of former,only
R2544 T3328 T3327 arg1Of former,the
R2545 T3328 T3329 arg1Of former,showed
R2546 T3329 T3325 arg2Of showed,and
R2547 T3331 T3329 arg2Of production,showed
R2548 T3331 T3330 arg1Of production,IL-10
R2549 T3331 T3332 arg1Of production,","
R2550 T3334 T3332 arg2Of development,","
R2551 T3334 T3333 arg1Of development,the
R2552 T3334 T3335 arg1Of development,of
R2553 T3338 T3335 arg2Of cells is,of
R2554 T3338 T3336 arg1Of cells is,high
R2555 T3338 T3337 arg1Of cells is,IL-10-producing
R2556 T3338 T3342 arg1Of cells is,related
R2557 T3340 T3339 arg1Of likely,most
R2558 T3342 T3340 arg1Of related,likely
R2559 T3342 T3341 arg1Of related,not
R2560 T3342 T3343 arg1Of related,to
R2561 T3345 T3343 arg2Of IL-2,to
R2562 T3345 T3344 arg1Of IL-2,limited
R2563 T3348 T3346 arg1Of T cells,Naive
R2564 T3348 T3347 arg1Of T cells,CD4+
R2565 T3348 T3349 arg1Of T cells,from
R2566 T3348 T3358 arg1Of T cells,","
R2567 T3348 T3359 arg2Of T cells,cultured
R2568 T3348 T3372 arg1Of T cells,resulted
R2569 T3354 T3353 arg2Of Rag1,(
R2570 T3355 T3353 arg3Of ),(
R2571 T3357 T3349 arg2Of animals,from
R2572 T3357 T3350 arg1Of animals,DO11.10/recombination-activating
R2573 T3357 T3351 arg1Of animals,gene
R2574 T3357 T3352 arg1Of animals,1
R2575 T3357 T3353 arg1Of animals,(
R2576 T3357 T3356 arg1Of animals,-deficient
R2577 T3359 T3360 arg1Of cultured,with
R2578 T3362 T3360 arg2Of doses,with
R2579 T3362 T3361 arg1Of doses,high
R2580 T3362 T3363 arg1Of doses,of
R2581 T3362 T3365 arg1Of doses,in
R2582 T3364 T3363 arg2Of antigen,of
R2583 T3367 T3365 arg2Of presence,in
R2584 T3367 T3366 arg1Of presence,the
R2585 T3367 T3368 arg1Of presence,of
R2586 T3369 T3368 arg2Of IL-12,of
R2587 T3372 T3370 arg1Of resulted,","
R2588 T3372 T3371 arg1Of resulted,also
R2589 T3372 T3373 arg1Of resulted,in
R2590 T3372 T3379 arg1Of resulted,","
R2591 T3372 T3380 modOf resulted,showing
R2592 T3375 T3373 arg2Of expression,in
R2593 T3375 T3374 arg1Of expression,IL-10
R2594 T3375 T3376 arg1Of expression,by
R2595 T3378 T3376 arg2Of cells,by
R2596 T3378 T3377 arg1Of cells,Th1
R2597 T3383 T3382 arg1Of expression,this
R2598 T3383 T3384 arg1Of expression,was
R2599 T3383 T3386 arg1Of expression,dependent
R2600 T3384 T3380 arg2Of was,showing
R2601 T3384 T3381 arg1Of was,that
R2602 T3384 T3385 arg1Of was,not
R2603 T3386 T3384 arg2Of dependent,was
R2604 T3386 T3387 arg1Of dependent,on
R2605 T3389 T3387 arg2Of presence,on
R2606 T3389 T3388 arg1Of presence,the
R2607 T3389 T3390 arg1Of presence,of
R2608 T3391 T3392 arg1Of effector,or
R2609 T3393 T3392 arg2Of memory,or
R2610 T3394 T3391 arg1Of T cells,effector
R2611 T3394 T3393 arg1Of T cells,memory
R2612 T3394 T3395 arg1Of T cells,or
R2613 T3395 T3390 arg2Of or,of
R2614 T3397 T3395 arg2Of cells,or
R2615 T3397 T3396 arg1Of cells,Treg
R2616 T3397 T3398 arg1Of cells,(
R2617 T3399 T3398 arg2Of Figure S2,(
R2618 T3400 T3398 arg3Of ),(
R2619 T3402 T3403 arg1Of it,has
R2620 T3402 T3404 arg1Of it,been
R2621 T3402 T3405 arg2Of it,suggested
R2622 T3405 T3401 arg2Of suggested,Although
R2623 T3405 T3403 arg2Of suggested,has
R2624 T3405 T3404 arg2Of suggested,been
R2625 T3407 T3408 arg1Of TGF-β,can
R2626 T3407 T3409 arg1Of TGF-β,induce
R2627 T3409 T3405 arg3Of induce,suggested
R2628 T3409 T3406 arg1Of induce,that
R2629 T3409 T3408 arg2Of induce,can
R2630 T3410 T3409 arg2Of IL-10,induce
R2631 T3410 T3411 arg1Of IL-10,in
R2632 T3413 T3411 arg2Of T cells,in
R2633 T3413 T3412 arg1Of T cells,CD4+
R2634 T3413 T3414 arg1Of T cells,(
R2635 T3416 T3415 arg1Of et al.,Kitani
R2636 T3416 T3417 arg1Of et al.,","
R2637 T3416 T3419 arg1Of et al.,;
R2638 T3418 T3417 arg2Of 2003,","
R2639 T3419 T3414 arg2Of ;,(
R2640 T3420 T3419 arg2Of Schiott,;
R2641 T3420 T3421 arg1Of Schiott,et al.
R2642 T3420 T3422 arg1Of Schiott,","
R2643 T3423 T3422 arg2Of 2000,","
R2644 T3424 T3414 arg3Of ),(
R2645 T3426 T3427 arg1Of we,found
R2646 T3427 T3401 arg1Of found,Although
R2647 T3427 T3425 arg1Of found,","
R2648 T3431 T3432 arg1Of Th1,and
R2649 T3433 T3432 arg2Of Th2,and
R2650 T3434 T3429 arg2Of cells,in
R2651 T3434 T3430 arg1Of cells,developing
R2652 T3434 T3431 arg1Of cells,Th1
R2653 T3434 T3433 arg1Of cells,Th2
R2654 T3435 T3436 arg1Of this,was
R2655 T3436 T3427 arg2Of was,found
R2656 T3436 T3428 arg1Of was,that
R2657 T3436 T3429 arg1Of was,in
R2658 T3436 T3437 arg1Of was,not
R2659 T3439 T3436 arg2Of case,was
R2660 T3439 T3438 arg1Of case,the
R2661 T3439 T3440 arg1Of case,(
R2662 T3441 T3440 arg2Of data,(
R2663 T3441 T3443 arg2Of data,shown
R2664 T3443 T3442 arg1Of shown,not
R2665 T3444 T3440 arg3Of ),(
R2666 T3446 T3445 arg2Of fact,In
R2667 T3448 T3449 arg1Of neutralization,of
R2668 T3448 T3451 arg1Of neutralization,led
R2669 T3450 T3449 arg2Of TGF-β,of
R2670 T3451 T3445 arg1Of led,In
R2671 T3451 T3447 arg1Of led,","
R2672 T3451 T3452 arg1Of led,to
R2673 T3455 T3452 arg2Of production,to
R2674 T3455 T3453 arg2Of production,increased
R2675 T3455 T3454 arg1Of production,IL-10
R2676 T3455 T3456 arg1Of production,by
R2677 T3459 T3456 arg2Of subsets,by
R2678 T3459 T3457 arg1Of subsets,both
R2679 T3459 T3458 arg1Of subsets,T cell
R2680 T3459 T3460 arg1Of subsets,(
R2681 T3461 T3460 arg2Of Figure S3,(
R2682 T3462 T3460 arg3Of ),(
R2683 T3466 T3465 arg1Of development,the
R2684 T3466 T3467 arg1Of development,of
R2685 T3466 T3472 arg1Of development,depended
R2686 T3470 T3467 arg2Of cells,of
R2687 T3470 T3468 arg1Of cells,IL-10-producing
R2688 T3470 T3469 arg1Of cells,Th1
R2689 T3472 T3463 arg1Of depended,Thus
R2690 T3472 T3464 arg1Of depended,","
R2691 T3472 T3471 arg1Of depended,only
R2692 T3472 T3473 arg1Of depended,on
R2693 T3472 T3485 arg1Of depended,on
R2694 T3472 T3495 arg1Of depended,on
R2695 T3473 T3483 arg1Of on,and
R2696 T3475 T3473 arg2Of presence,on
R2697 T3475 T3474 arg1Of presence,the
R2698 T3475 T3476 arg1Of presence,of
R2699 T3475 T3478 arg1Of presence,together
R2700 T3477 T3476 arg2Of IL-12,of
R2701 T3478 T3479 arg1Of together,with
R2702 T3482 T3479 arg2Of dose,with
R2703 T3482 T3480 arg1Of dose,high
R2704 T3482 T3481 arg1Of dose,antigen
R2705 T3485 T3494 arg1Of on,or
R2706 T3488 T3485 arg2Of factors,on
R2707 T3488 T3486 arg1Of factors,other
R2708 T3488 T3487 arg1Of factors,soluble
R2709 T3488 T3490 arg1Of factors,as
R2710 T3490 T3489 arg1Of as,such
R2711 T3491 T3492 arg1Of IL-2,or
R2712 T3492 T3490 arg2Of or,as
R2713 T3493 T3492 arg2Of TGF-β,or
R2714 T3494 T3483 arg2Of or,and
R2715 T3494 T3484 arg1Of or,not
R2716 T3495 T3494 arg2Of on,or
R2717 T3497 T3495 arg2Of presence,on
R2718 T3497 T3496 arg1Of presence,the
R2719 T3497 T3498 arg1Of presence,of
R2720 T3501 T3498 arg2Of types,of
R2721 T3501 T3499 arg1Of types,other
R2722 T3501 T3500 arg1Of types,T cell
R3773 T5042 T5041 arg2Of Dependent,Is
R3774 T5042 T5043 arg1Of Dependent,on
R3775 T5042 T5047 arg1Of Dependent,on
R3776 T5043 T5045 arg1Of on,but
R3777 T5044 T5043 arg2Of STAT4,on
R3778 T5047 T5045 arg2Of on,but
R3779 T5047 T5046 arg1Of on,Not
R3780 T5048 T5049 arg1Of STAT6,","
R3781 T5049 T5052 arg1Of ",",or
R3782 T5050 T5049 arg2Of IFN-γ,","
R3783 T5052 T5047 arg2Of or,on
R3784 T5052 T5051 arg1Of or,","
R3785 T5054 T5052 arg2Of Signaling,or
R3786 T5054 T5053 arg1Of Signaling,IL-4
R3787 T5057 T5055 arg1Of elucidate,To
R3788 T5057 T5056 arg1Of elucidate,further
R3789 T5059 T5057 arg2Of mechanisms,elucidate
R3790 T5059 T5058 arg1Of mechanisms,the
R3791 T5059 T5060 arg2Of mechanisms,required
R3792 T5060 T5061 arg1Of required,for
R3793 T5063 T5061 arg2Of development,for
R3794 T5063 T5062 arg1Of development,the
R3795 T5063 T5064 arg1Of development,of
R3796 T5066 T5064 arg2Of cells,of
R3797 T5066 T5065 arg1Of cells,Th1
R3798 T5066 T5067 arg1Of cells,producing
R3799 T5068 T5067 arg2Of IL-10,producing
R3800 T5070 T5057 arg1Of we,elucidate
R3801 T5070 T5071 arg1Of we,investigated
R3802 T5071 T5055 modOf investigated,To
R3803 T5071 T5069 arg1Of investigated,","
R3804 T5073 T5071 arg2Of role,investigated
R3805 T5073 T5072 arg1Of role,the
R3806 T5073 T5074 arg1Of role,of
R3807 T5073 T5082 arg2Of role,activated
R3808 T5075 T5074 arg2Of STAT4,of
R3809 T5075 T5076 arg1Of STAT4,","
R3810 T5077 T5076 arg2Of one,","
R3811 T5077 T5078 arg1Of one,of
R3812 T5081 T5078 arg2Of pathways,of
R3813 T5081 T5079 arg1Of pathways,the
R3814 T5081 T5080 arg1Of pathways,signaling
R3815 T5084 T5082 arg1Of IL-12,activated
R3816 T5084 T5083 arg2Of IL-12,by
R3817 T5084 T5085 arg1Of IL-12,(
R3818 T5087 T5085 arg2Of et al.,(
R3819 T5087 T5086 arg1Of et al.,Murphy
R3820 T5087 T5088 arg1Of et al.,","
R3821 T5089 T5088 arg2Of 2000,","
R3822 T5090 T5085 arg3Of ),(
R3823 T5094 T5091 arg1Of T cells,Naive
R3824 T5094 T5092 arg1Of T cells,CD4+
R3825 T5094 T5093 arg1Of T cells,D011.10
R3826 T5094 T5095 arg1Of T cells,deficient
R3827 T5094 T5098 arg1Of T cells,(
R3828 T5094 T5104 arg1Of T cells,were
R3829 T5094 T5105 arg2Of T cells,cultured
R3830 T5095 T5096 arg1Of deficient,in
R3831 T5097 T5096 arg2Of STAT4,in
R3832 T5100 T5098 arg2Of et al.,(
R3833 T5100 T5099 arg1Of et al.,Ouyang
R3834 T5100 T5101 arg1Of et al.,","
R3835 T5102 T5101 arg2Of 1998,","
R3836 T5103 T5098 arg3Of ),(
R3837 T5105 T5104 arg2Of cultured,were
R3838 T5105 T5106 arg1Of cultured,in
R3839 T5108 T5106 arg2Of presence,in
R3840 T5108 T5107 arg1Of presence,the
R3841 T5108 T5109 arg1Of presence,of
R3842 T5110 T5111 arg1Of IL-12,and
R3843 T5111 T5109 arg2Of and,of
R3844 T5112 T5111 arg2Of OVA,and
R3845 T5117 T5115 arg1Of cells,IL-10-producing
R3846 T5117 T5116 arg1Of cells,Th1
R3847 T5117 T5118 arg1Of cells,were
R3848 T5117 T5119 arg2Of cells,differentiated
R3849 T5119 T5113 arg1Of differentiated,Again
R3850 T5119 T5114 arg1Of differentiated,","
R3851 T5119 T5118 arg2Of differentiated,were
R3852 T5119 T5120 arg1Of differentiated,at
R3853 T5119 T5125 arg1Of differentiated,in
R3854 T5124 T5120 arg2Of dose,at
R3855 T5124 T5121 arg1Of dose,the
R3856 T5124 T5122 arg1Of dose,high
R3857 T5124 T5123 arg1Of dose,antigen
R3858 T5127 T5125 arg2Of presence,in
R3859 T5127 T5126 arg1Of presence,the
R3860 T5127 T5128 arg1Of presence,of
R3861 T5127 T5130 arg1Of presence,in
R3862 T5129 T5128 arg2Of IL-12,of
R3863 T5132 T5130 arg2Of T cells,in
R3864 T5132 T5131 arg1Of T cells,DO11.10
R3865 T5132 T5133 arg1Of T cells,(
R3866 T5134 T5133 arg2Of Figure 2A,(
R3867 T5135 T5133 arg3Of ),(
R3868 T5137 T5136 arg2Of contrast,In
R3869 T5139 T5140 arg1Of in,the
R3870 T5139 T5142 arg1Of in,of
R3871 T5141 T5139 arg2Of absence,in
R3872 T5143 T5139 arg3Of STAT4,in
R3873 T5146 T5145 arg1Of percentage,the
R3874 T5146 T5147 arg1Of percentage,of
R3875 T5146 T5151 arg1Of percentage,was
R3876 T5146 T5153 arg2Of percentage,diminished
R3877 T5148 T5147 arg2Of cells,of
R3878 T5148 T5149 arg1Of cells,expressing
R3879 T5150 T5149 arg2Of IFN-γ,expressing
R3880 T5153 T5136 arg1Of diminished,In
R3881 T5153 T5138 arg1Of diminished,","
R3882 T5153 T5139 arg1Of diminished,in
R3883 T5153 T5144 arg1Of diminished,","
R3884 T5153 T5151 arg2Of diminished,was
R3885 T5153 T5152 arg1Of diminished,dramatically
R3886 T5153 T5154 arg1Of diminished,as
R3887 T5155 T5156 arg1Of expected,and
R3888 T5156 T5154 arg2Of and,as
R3889 T5156 T5175 arg1Of and,","
R3890 T5156 T5176 modOf and,suggesting
R3891 T5157 T5156 arg2Of resulted,and
R3892 T5157 T5158 arg1Of resulted,in
R3893 T5160 T5159 arg1Of increase,an
R3894 T5160 T5161 arg1Of increase,in
R3895 T5160 T5169 arg1Of increase,but
R3896 T5163 T5161 arg2Of percentage,in
R3897 T5163 T5162 arg1Of percentage,the
R3898 T5163 T5164 arg1Of percentage,of
R3899 T5165 T5164 arg2Of cells,of
R3900 T5165 T5166 arg1Of cells,expressing
R3901 T5167 T5166 arg2Of IL-4,expressing
R3902 T5169 T5158 arg2Of but,in
R3903 T5169 T5168 arg1Of but,","
R3904 T5169 T5170 arg1Of but,not
R3905 T5171 T5169 arg2Of IL-10,but
R3906 T5171 T5172 arg1Of IL-10,(
R3907 T5173 T5172 arg2Of Figure 2A,(
R3908 T5174 T5172 arg3Of ),(
R3909 T5178 T5179 arg1Of STAT4,contributes
R3910 T5179 T5176 arg2Of contributes,suggesting
R3911 T5179 T5177 arg1Of contributes,that
R3912 T5179 T5180 arg1Of contributes,to
R3913 T5182 T5180 arg2Of expression,to
R3914 T5182 T5181 arg1Of expression,IL-10
R3915 T5182 T5183 arg1Of expression,by
R3916 T5185 T5183 arg2Of cells,by
R3917 T5185 T5184 arg1Of cells,Th1
R3918 T5188 T5187 arg1Of expression,IL-10
R3919 T5188 T5189 arg1Of expression,is
R3920 T5188 T5190 arg2Of expression,associated
R3921 T5190 T5186 arg2Of associated,Because
R3922 T5190 T5189 arg2Of associated,is
R3923 T5190 T5191 arg1Of associated,with
R3924 T5196 T5191 arg2Of phenotype,with
R3925 T5196 T5192 arg1Of phenotype,an
R3926 T5196 T5193 arg1Of phenotype,IL-4-induced
R3927 T5196 T5194 arg1Of phenotype,Th2
R3928 T5196 T5195 arg1Of phenotype,cell
R3929 T5198 T5199 arg1Of we,investigated
R3930 T5199 T5186 arg1Of investigated,Because
R3931 T5199 T5197 arg1Of investigated,","
R3932 T5202 T5201 arg1Of differentiation,the
R3933 T5202 T5203 arg1Of differentiation,of
R3934 T5202 T5208 arg1Of differentiation,depended
R3935 T5207 T5203 arg2Of cells,of
R3936 T5207 T5204 arg1Of cells,the
R3937 T5207 T5205 arg1Of cells,IL-10-producing
R3938 T5207 T5206 arg1Of cells,Th1
R3939 T5208 T5199 arg2Of depended,investigated
R3940 T5208 T5200 arg1Of depended,whether
R3941 T5208 T5209 arg1Of depended,on
R3942 T5208 T5211 arg1Of depended,through
R3943 T5208 T5215 arg1Of depended,via
R3944 T5208 T5218 arg1Of depended,(
R3945 T5210 T5209 arg2Of signaling,on
R3946 T5214 T5211 arg2Of receptor,through
R3947 T5214 T5212 arg1Of receptor,the
R3948 T5214 T5213 arg1Of receptor,IL-4
R3949 T5217 T5215 arg2Of activation,via
R3950 T5217 T5216 arg1Of activation,STAT6
R3951 T5219 T5220 arg1Of Glimcher,and
R3952 T5220 T5218 arg2Of and,(
R3953 T5220 T5222 arg1Of and,","
R3954 T5220 T5224 arg1Of and,;
R3955 T5221 T5220 arg2Of Murphy,and
R3956 T5223 T5222 arg2Of 2000,","
R3957 T5225 T5224 arg2Of Murphy,;
R3958 T5225 T5226 arg1Of Murphy,et al.
R3959 T5225 T5227 arg1Of Murphy,","
R3960 T5228 T5227 arg2Of 2000,","
R3961 T5229 T5218 arg3Of ),(
R3962 T5231 T5230 arg1Of absence,The
R3963 T5231 T5232 arg1Of absence,of
R3964 T5231 T5234 arg1Of absence,did
R3965 T5231 T5236 arg1Of absence,impair
R3966 T5233 T5232 arg2Of STAT6,of
R3967 T5236 T5234 arg2Of impair,did
R3968 T5236 T5235 arg1Of impair,not
R3969 T5238 T5236 arg2Of differentiation,impair
R3970 T5238 T5237 arg1Of differentiation,the
R3971 T5238 T5239 arg1Of differentiation,of
R3972 T5238 T5243 arg1Of differentiation,in
R3973 T5242 T5239 arg2Of cells,of
R3974 T5242 T5240 arg1Of cells,IL-10-producing
R3975 T5242 T5241 arg1Of cells,Th1
R3976 T5245 T5243 arg2Of presence,in
R3977 T5245 T5244 arg1Of presence,the
R3978 T5245 T5246 arg1Of presence,of
R3979 T5247 T5248 arg1Of IL-12,and
R3980 T5248 T5246 arg2Of and,of
R3981 T5248 T5250 arg1Of and,(
R3982 T5249 T5248 arg2Of OVA,and
R3983 T5251 T5250 arg2Of Figure 2A,(
R3984 T5252 T5250 arg3Of ),(
R3985 T5254 T5253 arg2Of fact,In
R3986 T5258 T5256 arg1Of percentage,a
R3987 T5258 T5257 arg1Of percentage,higher
R3988 T5258 T5259 arg1Of percentage,of
R3989 T5258 T5266 arg1Of percentage,produced
R3990 T5261 T5259 arg2Of cells,of
R3991 T5261 T5260 arg1Of cells,STAT6-deficient
R3992 T5261 T5262 arg1Of cells,compared
R3993 T5263 T5262 arg2Of with,compared
R3994 T5265 T5263 arg2Of cells,with
R3995 T5265 T5264 arg1Of cells,WT
R3996 T5266 T5253 arg1Of produced,In
R3997 T5266 T5255 arg1Of produced,","
R3998 T5268 T5269 arg1Of IL-10,and
R3999 T5269 T5266 arg2Of and,produced
R4000 T5269 T5267 arg1Of and,both
R4001 T5269 T5271 arg1Of and,(
R4002 T5269 T5274 arg1Of and,","
R4003 T5269 T5275 arg1Of and,which
R4004 T5269 T5276 arg1Of and,may
R4005 T5269 T5277 arg1Of and,be
R4006 T5270 T5269 arg2Of IFN-γ,and
R4007 T5272 T5271 arg2Of Figure 2A,(
R4008 T5273 T5271 arg3Of ),(
R4009 T5277 T5276 arg2Of be,may
R4010 T5279 T5277 arg2Of result,be
R4011 T5279 T5278 arg1Of result,the
R4012 T5279 T5280 arg1Of result,of
R4013 T5282 T5280 arg2Of loss,of
R4014 T5282 T5281 arg1Of loss,the
R4015 T5282 T5283 arg1Of loss,of
R4016 T5282 T5287 arg1Of loss,over
R4017 T5286 T5283 arg2Of control,of
R4018 T5286 T5284 arg1Of control,Th2
R4019 T5286 T5285 arg1Of control,cell
R4020 T5291 T5287 arg2Of response,over
R4021 T5291 T5288 arg1Of response,a
R4022 T5291 T5289 arg1Of response,Th1
R4023 T5291 T5290 arg1Of response,cell
R4024 T5293 T5292 arg2Of expected,As
R4025 T5295 T5296 arg1Of lack,of
R4026 T5295 T5298 arg1Of lack,abrogated
R4027 T5297 T5296 arg2Of STAT6,of
R4028 T5298 T5292 arg1Of abrogated,As
R4029 T5298 T5294 arg1Of abrogated,","
R4030 T5300 T5301 arg1Of IL-4,and
R4031 T5301 T5298 arg2Of and,abrogated
R4032 T5301 T5299 arg1Of and,both
R4033 T5301 T5304 arg1Of and,by
R4034 T5303 T5301 arg2Of production,and
R4035 T5303 T5302 arg1Of production,IL-10
R4036 T5305 T5304 arg2Of T cells,by
R4037 T5305 T5306 arg2Of T cells,developed
R4038 T5306 T5307 arg1Of developed,with
R4039 T5306 T5310 arg1Of developed,with
R4040 T5307 T5309 arg1Of with,or
R4041 T5308 T5307 arg2Of IL-4,with
R4042 T5310 T5309 arg2Of with,or
R4043 T5313 T5310 arg2Of dose,with
R4044 T5313 T5311 arg1Of dose,low
R4045 T5313 T5312 arg1Of dose,antigen
R4046 T5313 T5314 arg1Of dose,(
R4047 T5316 T5317 arg1Of 2B,and
R4048 T5317 T5314 arg2Of and,(
R4049 T5317 T5315 arg1Of and,Figures
R4050 T5318 T5317 arg2Of 2C,and
R4051 T5319 T5314 arg3Of ),(
R4052 T5322 T5323 arg1Of in,the
R4053 T5322 T5325 arg1Of in,of
R4054 T5324 T5322 arg2Of absence,in
R4055 T5327 T5322 arg3Of signaling,in
R4056 T5327 T5326 arg1Of signaling,STAT4
R4057 T5329 T5330 arg1Of IL-10,and
R4058 T5330 T5333 arg1Of and,by
R4059 T5330 T5336 arg1Of and,was
R4060 T5332 T5330 arg2Of production,and
R4061 T5332 T5331 arg1Of production,IL-4
R4062 T5335 T5333 arg2Of cells,by
R4063 T5335 T5334 arg1Of cells,Th2
R4064 T5336 T5320 arg1Of was,However
R4065 T5336 T5321 arg1Of was,","
R4066 T5336 T5322 arg1Of was,in
R4067 T5336 T5328 arg1Of was,","
R4068 T5338 T5339 arg1Of anything,increased
R4069 T5339 T5336 arg2Of increased,was
R4070 T5339 T5337 arg1Of increased,if
R4071 T5339 T5340 arg1Of increased,(
R4072 T5342 T5343 arg1Of 2B,and
R4073 T5343 T5340 arg2Of and,(
R4074 T5343 T5341 arg1Of and,Figures
R4075 T5344 T5343 arg2Of 2C,and
R4076 T5345 T5340 arg3Of ),(
R4077 T5349 T5348 arg2Of contrast,in
R4078 T5349 T5350 arg1Of contrast,to
R4079 T5351 T5350 arg2Of what,to
R4080 T5351 T5352 arg1Of what,was
R4081 T5351 T5353 arg2Of what,observed
R4082 T5353 T5352 arg2Of observed,was
R4083 T5353 T5354 arg1Of observed,under
R4084 T5356 T5354 arg2Of conditions,under
R4085 T5356 T5355 arg1Of conditions,Th1
R4086 T5359 T5358 arg1Of expression,IL-10
R4087 T5359 T5360 arg1Of expression,by
R4088 T5359 T5363 arg1Of expression,depended
R4089 T5362 T5360 arg2Of cells,by
R4090 T5362 T5361 arg1Of cells,Th2
R4091 T5363 T5346 arg1Of depended,Thus
R4092 T5363 T5347 arg1Of depended,","
R4093 T5363 T5348 arg1Of depended,in
R4094 T5363 T5357 arg1Of depended,","
R4095 T5363 T5364 arg1Of depended,on
R4096 T5363 T5369 arg1Of depended,on
R4097 T5364 T5367 arg1Of on,but
R4098 T5365 T5364 arg2Of STAT6,on
R4099 T5367 T5366 arg1Of but,","
R4100 T5369 T5367 arg2Of on,but
R4101 T5369 T5368 arg1Of on,not
R4102 T5370 T5371 arg1Of STAT4,","
R4103 T5371 T5369 arg2Of ",",on
R4104 T5371 T5373 arg1Of ",",(
R4105 T5372 T5371 arg2Of signaling,","
R4106 T5375 T5376 arg1Of 2B,and
R4107 T5376 T5373 arg2Of and,(
R4108 T5376 T5374 arg1Of and,Figures
R4109 T5377 T5376 arg2Of 2C,and
R4110 T5378 T5373 arg3Of ),(
R4111 T5380 T5379 arg1Of investigate,To
R4112 T5383 T5382 arg1Of inability,the
R4113 T5383 T5384 arg1Of inability,of
R4114 T5383 T5387 modOf inability,to
R4115 T5383 T5390 arg1Of inability,might
R4116 T5383 T5391 arg1Of inability,be
R4117 T5383 T5393 arg1Of inability,to
R4118 T5386 T5384 arg2Of T cells,of
R4119 T5386 T5385 arg1Of T cells,STAT4-deficient
R4120 T5388 T5387 arg1Of produce,to
R4121 T5389 T5388 arg2Of IL-10,produce
R4122 T5391 T5380 arg2Of be,investigate
R4123 T5391 T5381 arg1Of be,whether
R4124 T5391 T5390 arg2Of be,might
R4125 T5391 T5398 arg1Of be,","
R4126 T5391 T5399 arg1Of be,as
R4127 T5393 T5391 arg2Of to,be
R4128 T5393 T5392 arg1Of to,due
R4129 T5395 T5393 arg2Of absence,to
R4130 T5395 T5394 arg1Of absence,the
R4131 T5395 T5396 arg1Of absence,of
R4132 T5397 T5396 arg2Of IFN-γ,of
R4133 T5400 T5399 arg2Of suggested,as
R4134 T5400 T5401 arg1Of suggested,before
R4135 T5401 T5402 arg1Of before,(
R4136 T5404 T5402 arg2Of et al.,(
R4137 T5404 T5403 arg1Of et al.,Shaw
R4138 T5404 T5405 arg1Of et al.,","
R4139 T5406 T5405 arg2Of 2006,","
R4140 T5407 T5402 arg3Of ),(
R4141 T5409 T5410 arg1Of we,differentiated
R4142 T5410 T5401 arg2Of differentiated,before
R4143 T5410 T5408 arg1Of differentiated,","
R4144 T5410 T5418 arg1Of differentiated,in
R4145 T5415 T5411 arg1Of naive,DO11.10
R4146 T5415 T5412 arg1Of naive,or
R4147 T5415 T5413 arg1Of naive,DO11.10
R4148 T5415 T5414 arg1Of naive,IFN-γ-deficient
R4149 T5417 T5410 arg2Of T cells,differentiated
R4150 T5417 T5415 arg1Of T cells,naive
R4151 T5417 T5416 arg1Of T cells,CD4+
R4152 T5420 T5418 arg2Of presence,in
R4153 T5420 T5419 arg1Of presence,the
R4154 T5420 T5421 arg1Of presence,of
R4155 T5422 T5423 arg1Of IL-12,and
R4156 T5423 T5421 arg2Of and,of
R4157 T5425 T5423 arg2Of doses,and
R4158 T5425 T5424 arg1Of doses,increasing
R4159 T5425 T5426 arg1Of doses,of
R4160 T5427 T5426 arg2Of OVA,of
R4161 T5429 T5430 arg1Of secretion,of
R4162 T5429 T5432 arg1Of secretion,as
R4163 T5429 T5439 arg1Of secretion,and
R4164 T5431 T5430 arg2Of IL-10,of
R4165 T5433 T5432 arg2Of induced,as
R4166 T5437 T5433 arg1Of dose,induced
R4167 T5437 T5434 arg2Of dose,by
R4168 T5437 T5435 arg1Of dose,high
R4169 T5437 T5436 arg1Of dose,antigen
R4170 T5439 T5428 arg1Of and,The
R4171 T5439 T5438 arg1Of and,","
R4172 T5439 T5441 arg1Of and,was
R4173 T5439 T5443 arg2Of and,affected
R4174 T5440 T5439 arg2Of IL-12,and
R4175 T5443 T5441 arg2Of affected,was
R4176 T5443 T5442 arg1Of affected,not
R4177 T5443 T5452 arg1Of affected,","
R4178 T5443 T5453 modOf affected,showing
R4179 T5446 T5443 arg1Of absence,affected
R4180 T5446 T5444 arg2Of absence,by
R4181 T5446 T5445 arg1Of absence,an
R4182 T5446 T5447 arg1Of absence,of
R4183 T5448 T5447 arg2Of IFN-γ,of
R4184 T5448 T5449 arg1Of IFN-γ,(
R4185 T5450 T5449 arg2Of Figure 2D,(
R4186 T5451 T5449 arg3Of ),(
R4187 T5457 T5455 arg1Of of IL-10,the
R4188 T5457 T5456 arg1Of of IL-10,expression
R4189 T5457 T5458 arg1Of of IL-10,by
R4190 T5457 T5461 arg1Of of IL-10,is
R4191 T5457 T5462 arg1Of of IL-10,independent
R4192 T5460 T5458 arg2Of cells,by
R4193 T5460 T5459 arg1Of cells,Th1
R4194 T5461 T5453 arg2Of is,showing
R4195 T5461 T5454 arg1Of is,that
R4196 T5462 T5461 arg2Of independent,is
R4197 T5462 T5463 arg1Of independent,of
R4198 T5464 T5463 arg2Of IFN-γ,of
R4199 T5465 T5466 arg1Of In,the
R4200 T5465 T5468 arg1Of In,of
R4201 T5467 T5465 arg2Of absence,In
R4202 T5469 T5465 arg3Of IFN-γ,In
R4203 T5471 T5472 arg1Of we,observed
R4204 T5472 T5465 arg1Of observed,In
R4205 T5472 T5470 arg1Of observed,","
R4206 T5472 T5479 arg1Of observed,as
R4207 T5474 T5472 arg2Of increase,observed
R4208 T5474 T5473 arg1Of increase,an
R4209 T5474 T5475 arg1Of increase,in
R4210 T5478 T5475 arg2Of IL-4,in
R4211 T5478 T5476 arg1Of IL-4,the
R4212 T5478 T5477 arg2Of IL-4,secreted
R4213 T5480 T5479 arg2Of expected,as
R4214 T5480 T5481 arg1Of expected,(
R4215 T5482 T5481 arg2Of data,(
R4216 T5482 T5484 arg2Of data,shown
R4217 T5484 T5483 arg1Of shown,not
R4218 T5485 T5481 arg3Of ),(
R4219 T5486 T5488 arg1Of We,tested
R4220 T5488 T5487 arg1Of tested,also
R4221 T5488 T5489 arg1Of tested,for
R4222 T5492 T5489 arg2Of role,for
R4223 T5492 T5490 arg1Of role,any
R4224 T5492 T5491 arg1Of role,potential
R4225 T5492 T5493 arg1Of role,of
R4226 T5492 T5495 arg1Of role,in
R4227 T5494 T5493 arg2Of IL-4,of
R4228 T5497 T5495 arg2Of development,in
R4229 T5497 T5496 arg1Of development,the
R4230 T5497 T5498 arg1Of development,of
R4231 T5500 T5498 arg2Of cells,of
R4232 T5500 T5499 arg1Of cells,Th1
R4233 T5500 T5501 arg1Of cells,producing
R4234 T5501 T5503 arg1Of producing,by
R4235 T5502 T5501 arg2Of IL-10,producing
R4236 T5504 T5503 arg2Of culturing,by
R4237 T5505 T5506 arg1Of DO11.10,or
R4238 T5506 T5504 arg2Of or,culturing
R4239 T5511 T5506 arg2Of T cells,or
R4240 T5511 T5507 arg1Of T cells,DO11.10
R4241 T5511 T5508 arg1Of T cells,IL-4-deficient
R4242 T5511 T5509 arg1Of T cells,naive
R4243 T5511 T5510 arg1Of T cells,CD4+
R4244 T5511 T5512 arg1Of T cells,with
R4245 T5513 T5514 arg1Of IL-12,and
R4246 T5514 T5512 arg2Of and,with
R4247 T5516 T5514 arg2Of doses,and
R4248 T5516 T5515 arg1Of doses,increasing
R4249 T5516 T5517 arg1Of doses,of
R4250 T5518 T5517 arg2Of antigen,of
R4251 T5520 T5519 arg2Of observed,As
R4252 T5520 T5521 arg1Of observed,in
R4253 T5523 T5521 arg2Of absence,in
R4254 T5523 T5522 arg1Of absence,the
R4255 T5523 T5524 arg1Of absence,of
R4256 T5525 T5524 arg2Of STAT6,of
R4257 T5525 T5526 arg1Of STAT6,(
R4258 T5527 T5526 arg2Of Figure 2A,(
R4259 T5528 T5526 arg3Of ),(
R4260 T5531 T5530 arg1Of deficiency,IL-4
R4261 T5531 T5532 arg1Of deficiency,had
R4262 T5531 T5548 arg1Of deficiency,compromised
R4263 T5532 T5535 arg1Of had,on
R4264 T5532 T5547 arg1Of had,but
R4265 T5534 T5532 arg2Of effect,had
R4266 T5534 T5533 arg1Of effect,no
R4267 T5537 T5535 arg2Of development,on
R4268 T5537 T5536 arg1Of development,the
R4269 T5537 T5538 arg1Of development,of
R4270 T5540 T5538 arg2Of cells,of
R4271 T5540 T5539 arg1Of cells,Th1
R4272 T5540 T5541 arg1Of cells,producing
R4273 T5542 T5541 arg2Of IL-10,producing
R4274 T5542 T5543 arg1Of IL-10,(
R4275 T5544 T5543 arg2Of Figure 2E,(
R4276 T5545 T5543 arg3Of ),(
R4277 T5547 T5519 arg1Of but,As
R4278 T5547 T5529 arg1Of but,","
R4279 T5547 T5546 arg1Of but,","
R4280 T5548 T5547 arg2Of compromised,but
R4281 T5550 T5548 arg2Of development,compromised
R4282 T5550 T5549 arg1Of development,the
R4283 T5550 T5551 arg1Of development,of
R4284 T5553 T5551 arg2Of cells,of
R4285 T5553 T5552 arg1Of cells,Th2
R4286 T5553 T5554 arg1Of cells,producing
R4287 T5555 T5554 arg2Of IL-10,producing
R4288 T5555 T5556 arg1Of IL-10,(
R4289 T5557 T5556 arg2Of Figure 2F,(
R4290 T5558 T5556 arg3Of ),(
R4291 T5562 T5561 arg1Of data,our
R4292 T5562 T5563 arg1Of data,suggested
R4293 T5563 T5559 arg1Of suggested,Thus
R4294 T5563 T5560 arg1Of suggested,","
R4295 T5566 T5565 arg1Of production,IL-10
R4296 T5566 T5567 arg1Of production,by
R4297 T5566 T5572 arg1Of production,was
R4298 T5566 T5573 arg1Of production,dependent
R4299 T5568 T5569 arg1Of Th1,or
R4300 T5570 T5569 arg2Of Th2,or
R4301 T5571 T5567 arg2Of cells,by
R4302 T5571 T5568 arg1Of cells,Th1
R4303 T5571 T5570 arg1Of cells,Th2
R4304 T5572 T5563 arg2Of was,suggested
R4305 T5572 T5564 arg1Of was,that
R4306 T5572 T5583 arg1Of was,","
R4307 T5572 T5584 arg1Of was,given
R4308 T5573 T5572 arg2Of dependent,was
R4309 T5573 T5574 arg1Of dependent,on
R4310 T5578 T5574 arg2Of pathways,on
R4311 T5578 T5575 arg1Of pathways,the
R4312 T5578 T5576 arg1Of pathways,specific
R4313 T5578 T5577 arg1Of pathways,signaling
R4314 T5578 T5579 arg2Of pathways,required
R4315 T5579 T5580 arg1Of required,for
R4316 T5582 T5580 arg2Of differentiation,for
R4317 T5582 T5581 arg1Of differentiation,their
R4318 T5586 T5587 arg1Of STAT4,is
R4319 T5586 T5588 arg2Of STAT4,required
R4320 T5588 T5584 arg2Of required,given
R4321 T5588 T5585 arg1Of required,that
R4322 T5588 T5587 arg2Of required,is
R4323 T5588 T5589 arg1Of required,for
R4324 T5591 T5589 arg2Of induction,for
R4325 T5591 T5590 arg1Of induction,the
R4326 T5591 T5592 arg1Of induction,of
R4327 T5594 T5593 arg1Of production,IL-10
R4328 T5594 T5595 arg1Of production,by
R4329 T5594 T5598 arg1Of production,and
R4330 T5597 T5595 arg2Of cells,by
R4331 T5597 T5596 arg1Of cells,Th1
R4332 T5598 T5592 arg2Of and,of
R4333 T5599 T5598 arg2Of STAT6,and
R4334 T5599 T5600 arg1Of STAT6,for
R4335 T5602 T5600 arg2Of cells,for
R4336 T5602 T5601 arg1Of cells,Th2
R5322 T7044 T7042 arg1Of Doses,High
R5323 T7044 T7043 arg1Of Doses,Antigen
R5324 T7044 T7045 arg1Of Doses,and
R5325 T7045 T7047 arg1Of and,Are
R5326 T7045 T7048 arg2Of and,Required
R5327 T7046 T7045 arg2Of STAT4,and
R5328 T7048 T7047 arg2Of Required,Are
R5329 T7048 T7049 arg1Of Required,for
R5330 T7053 T7049 arg2Of Generation,for
R5331 T7053 T7050 arg1Of Generation,the
R5332 T7053 T7051 arg1Of Generation,In
R5333 T7053 T7052 arg1Of Generation,Vivo
R5334 T7053 T7054 arg1Of Generation,of
R5335 T7057 T7054 arg2Of Cells,of
R5336 T7057 T7055 arg1Of Cells,IL-10-Producing
R5337 T7057 T7056 arg1Of Cells,Th1
R5338 T7059 T7058 arg1Of address,To
R5339 T7061 T7059 arg2Of mechanisms,address
R5340 T7061 T7060 arg1Of mechanisms,the
R5341 T7061 T7062 arg1Of mechanisms,regulating
R5342 T7064 T7062 arg2Of production,regulating
R5343 T7064 T7063 arg1Of production,IL-10
R5344 T7064 T7065 arg1Of production,by
R5345 T7067 T7065 arg2Of cells,by
R5346 T7067 T7066 arg1Of cells,Th1
R5347 T7067 T7068 arg1Of cells,in vivo
R5348 T7070 T7059 arg1Of we,address
R5349 T7070 T7071 arg1Of we,transferred
R5350 T7070 T7079 arg1Of we,immunized
R5351 T7071 T7074 arg1Of transferred,into
R5352 T7071 T7078 arg1Of transferred,and
R5353 T7073 T7071 arg2Of cells,transferred
R5354 T7073 T7072 arg1Of cells,DO11.10
R5355 T7077 T7074 arg2Of mice,into
R5356 T7077 T7075 arg1Of mice,BALB/c
R5357 T7077 T7076 arg1Of mice,recipient
R5358 T7078 T7058 modOf and,To
R5359 T7078 T7069 arg1Of and,","
R5360 T7079 T7078 arg2Of immunized,and
R5361 T7079 T7082 arg1Of immunized,with
R5362 T7079 T7088 arg1Of immunized,with
R5363 T7079 T7090 arg1Of immunized,without
R5364 T7081 T7079 arg2Of recipients,immunized
R5365 T7081 T7080 arg1Of recipients,the
R5366 T7084 T7083 arg1Of high,very
R5367 T7085 T7082 arg2Of doses,with
R5368 T7085 T7084 arg1Of doses,high
R5369 T7085 T7086 arg1Of doses,of
R5370 T7087 T7086 arg2Of OVA-protein,of
R5371 T7088 T7089 arg1Of with,or
R5372 T7090 T7089 arg2Of without,or
R5373 T7092 T7088 arg2Of lipopolysacharide,with
R5374 T7092 T7090 arg2Of lipopolysacharide,without
R5375 T7092 T7091 arg2Of lipopolysacharide,added
R5376 T7092 T7093 arg1Of lipopolysacharide,(
R5377 T7094 T7093 arg2Of LPS,(
R5378 T7095 T7093 arg3Of ),(
R5379 T7096 T7097 arg1Of T cells,were
R5380 T7096 T7098 arg2Of T cells,recovered
R5381 T7096 T7109 arg1Of T cells,restimulated
R5382 T7098 T7097 arg2Of recovered,were
R5383 T7098 T7099 arg1Of recovered,from
R5384 T7098 T7106 arg1Of recovered,after
R5385 T7098 T7108 arg1Of recovered,and
R5386 T7103 T7099 arg2Of nodes,from
R5387 T7103 T7100 arg1Of nodes,the
R5388 T7103 T7101 arg1Of nodes,inguinal
R5389 T7103 T7102 arg1Of nodes,lymph
R5390 T7105 T7104 arg1Of days,3
R5391 T7106 T7105 arg1Of after,days
R5392 T7107 T7106 arg2Of priming,after
R5393 T7109 T7108 arg2Of restimulated,and
R5394 T7109 T7111 arg1Of restimulated,with
R5395 T7110 T7109 arg2Of in vitro,restimulated
R5396 T7113 T7111 arg2Of peptide,with
R5397 T7113 T7112 arg1Of peptide,OVA
R5398 T7113 T7114 arg1Of peptide,for
R5399 T7116 T7114 arg2Of hr,for
R5400 T7116 T7115 arg1Of hr,48
R5401 T7119 T7117 arg1Of immunization,This
R5402 T7119 T7118 arg1Of immunization,in vivo
R5403 T7119 T7120 arg1Of immunization,induced
R5404 T7120 T7126 arg1Of induced,and
R5405 T7121 T7122 arg1Of IL-10,and
R5406 T7123 T7122 arg2Of IFN-γ,and
R5407 T7124 T7120 arg2Of production,induced
R5408 T7124 T7121 arg1Of production,IL-10
R5409 T7124 T7123 arg1Of production,IFN-γ
R5410 T7126 T7125 arg1Of and,","
R5411 T7128 T7127 arg1Of amount,the
R5412 T7128 T7129 arg1Of amount,of
R5413 T7128 T7132 arg1Of amount,was
R5414 T7128 T7133 arg2Of amount,enhanced
R5415 T7131 T7129 arg2Of production,of
R5416 T7131 T7130 arg1Of production,IL-10
R5417 T7133 T7126 arg2Of enhanced,and
R5418 T7133 T7132 arg2Of enhanced,was
R5419 T7135 T7133 arg1Of addition,enhanced
R5420 T7135 T7134 arg2Of addition,by
R5421 T7135 T7136 arg1Of addition,of
R5422 T7135 T7138 arg1Of addition,in
R5423 T7135 T7145 arg1Of addition,with
R5424 T7137 T7136 arg2Of LPS,of
R5425 T7138 T7144 arg1Of in,and
R5426 T7140 T7138 arg2Of immunization,in
R5427 T7140 T7139 arg1Of immunization,the
R5428 T7140 T7141 arg1Of immunization,(
R5429 T7142 T7141 arg2Of Figure 3A,(
R5430 T7143 T7141 arg3Of ),(
R5431 T7145 T7144 arg2Of with,and
R5432 T7147 T7145 arg2Of doses,with
R5433 T7147 T7146 arg1Of doses,higher
R5434 T7147 T7148 arg1Of doses,of
R5435 T7147 T7150 arg1Of doses,(
R5436 T7149 T7148 arg2Of OVA,of
R5437 T7152 T7150 arg2Of μM,(
R5438 T7152 T7151 arg1Of μM,3
R5439 T7152 T7153 arg1Of μM,versus
R5440 T7155 T7153 arg2Of μM,versus
R5441 T7155 T7154 arg1Of μM,1
R5442 T7155 T7156 arg1Of μM,","
R5443 T7157 T7156 arg2Of data,","
R5444 T7157 T7159 arg2Of data,shown
R5445 T7159 T7158 arg1Of shown,not
R5446 T7160 T7150 arg3Of ),(
R5447 T7162 T7161 arg1Of test,To
R5448 T7164 T7162 arg2Of role,test
R5449 T7164 T7163 arg1Of role,the
R5450 T7164 T7165 arg1Of role,of
R5451 T7164 T7170 arg1Of role,in
R5452 T7166 T7167 arg1Of STAT4,and
R5453 T7168 T7167 arg2Of STAT6,and
R5454 T7169 T7165 arg2Of signaling,of
R5455 T7169 T7166 arg1Of signaling,STAT4
R5456 T7169 T7168 arg1Of signaling,STAT6
R5457 T7173 T7170 arg2Of development,in
R5458 T7173 T7171 arg1Of development,the
R5459 T7173 T7172 arg1Of development,in vivo
R5460 T7173 T7174 arg1Of development,of
R5461 T7177 T7174 arg2Of cells,of
R5462 T7177 T7175 arg1Of cells,IL-10-producing
R5463 T7177 T7176 arg1Of cells,Th1
R5464 T7179 T7162 arg1Of we,test
R5465 T7179 T7180 arg1Of we,transferred
R5466 T7180 T7161 modOf transferred,To
R5467 T7180 T7178 arg1Of transferred,","
R5468 T7181 T7182 arg1Of STAT4-,or
R5469 T7182 T7180 arg2Of or,transferred
R5470 T7183 T7184 arg1Of STAT6-deficient,or
R5471 T7185 T7184 arg2Of WT,or
R5472 T7187 T7182 arg2Of cells,or
R5473 T7187 T7183 arg1Of cells,STAT6-deficient
R5474 T7187 T7185 arg1Of cells,WT
R5475 T7187 T7186 arg1Of cells,DO11.10
R5476 T7187 T7188 arg1Of cells,into
R5477 T7187 T7193 arg2Of cells,immunized
R5478 T7188 T7192 arg1Of into,and
R5479 T7191 T7188 arg2Of mice,into
R5480 T7191 T7189 arg1Of mice,recipient
R5481 T7191 T7190 arg1Of mice,BALB/c
R5482 T7193 T7192 arg2Of immunized,and
R5483 T7193 T7194 arg1Of immunized,with
R5484 T7194 T7199 arg1Of with,before
R5485 T7195 T7196 arg1Of OVA-protein,plus
R5486 T7196 T7194 arg2Of plus,with
R5487 T7197 T7196 arg2Of LPS,plus
R5488 T7199 T7198 arg1Of before,as
R5489 T7201 T7200 arg1Of vivo,In
R5490 T7202 T7201 arg1Of expression,vivo
R5491 T7202 T7203 arg1Of expression,of
R5492 T7202 T7208 arg1Of expression,was
R5493 T7202 T7210 arg2Of expression,reduced
R5494 T7202 T7214 arg2Of expression,abrogated
R5495 T7205 T7206 arg1Of IL-10,and
R5496 T7206 T7203 arg2Of and,of
R5497 T7206 T7204 arg1Of and,both
R5498 T7207 T7206 arg2Of IFN-γ,and
R5499 T7210 T7211 arg1Of reduced,but
R5500 T7211 T7208 arg2Of but,was
R5501 T7211 T7209 arg1Of but,markedly
R5502 T7213 T7212 arg1Of completely,not
R5503 T7214 T7211 arg2Of abrogated,but
R5504 T7214 T7213 arg1Of abrogated,completely
R5505 T7214 T7215 arg1Of abrogated,in
R5506 T7214 T7227 arg1Of abrogated,","
R5507 T7214 T7228 modOf abrogated,suggesting
R5508 T7217 T7215 arg2Of absence,in
R5509 T7217 T7216 arg1Of absence,the
R5510 T7217 T7218 arg1Of absence,of
R5511 T7220 T7218 arg2Of signaling,of
R5512 T7220 T7219 arg1Of signaling,STAT4
R5513 T7220 T7221 arg1Of signaling,(
R5514 T7223 T7224 arg1Of 3B,and
R5515 T7224 T7221 arg2Of and,(
R5516 T7224 T7222 arg1Of and,Figures
R5517 T7225 T7224 arg2Of 3C,and
R5518 T7226 T7221 arg3Of ),(
R5519 T7230 T7228 arg2Of existence,suggesting
R5520 T7230 T7229 arg1Of existence,the
R5521 T7230 T7231 arg1Of existence,of
R5522 T7233 T7231 arg2Of mechanisms,of
R5523 T7233 T7232 arg1Of mechanisms,compensatory
R5524 T7233 T7234 arg1Of mechanisms,that
R5525 T7233 T7235 arg1Of mechanisms,were
R5526 T7233 T7236 arg1Of mechanisms,absent
R5527 T7236 T7235 arg2Of absent,were
R5528 T7236 T7237 arg1Of absent,in
R5529 T7240 T7237 arg2Of system,in
R5530 T7240 T7238 arg1Of system,the
R5531 T7240 T7239 arg1Of system,in vitro
R5532 T7241 T7242 arg1Of Signaling,through
R5533 T7241 T7244 arg1Of Signaling,had
R5534 T7243 T7242 arg2Of STAT6,through
R5535 T7244 T7247 arg1Of had,on
R5536 T7244 T7263 arg1Of had,by
R5537 T7246 T7244 arg2Of effect,had
R5538 T7246 T7245 arg1Of effect,no
R5539 T7247 T7262 arg1Of on,and
R5540 T7249 T7247 arg2Of production,on
R5541 T7249 T7248 arg1Of production,IL-10
R5542 T7249 T7250 arg1Of production,by
R5543 T7249 T7253 arg1Of production,as
R5544 T7252 T7250 arg2Of cells,by
R5545 T7252 T7251 arg1Of cells,Th1
R5546 T7254 T7253 arg2Of shown,as
R5547 T7258 T7254 arg1Of staining,shown
R5548 T7258 T7255 arg2Of staining,by
R5549 T7258 T7256 arg1Of staining,intracellular
R5550 T7258 T7257 arg1Of staining,cytokine
R5551 T7258 T7259 arg1Of staining,(
R5552 T7260 T7259 arg2Of ICS,(
R5553 T7261 T7259 arg3Of ),(
R5554 T7263 T7262 arg2Of by,and
R5555 T7264 T7263 arg2Of immunoassay,by
R5556 T7264 T7265 arg1Of immunoassay,in
R5557 T7267 T7265 arg2Of T cells,in
R5558 T7267 T7266 arg1Of T cells,STAT6-deficient
R5559 T7267 T7268 arg1Of T cells,(
R5560 T7270 T7271 arg1Of 3B,and
R5561 T7271 T7268 arg2Of and,(
R5562 T7271 T7269 arg1Of and,Figures
R5563 T7272 T7271 arg2Of 3C,and
R5564 T7273 T7268 arg3Of ),(
R6009 T7939 T7938 arg1Of Production,IL-10
R6010 T7939 T7940 arg1Of Production,Is
R6011 T7939 T7941 arg2Of Production,Maintained
R6012 T7941 T7940 arg2Of Maintained,Is
R6013 T7946 T7947 arg1Of Strength,and
R6014 T7947 T7941 arg1Of and,Maintained
R6015 T7947 T7942 arg2Of and,by
R6016 T7947 T7943 arg1Of and,High
R6017 T7947 T7944 arg1Of and,TCR
R6018 T7947 T7945 arg1Of and,Signal
R6019 T7948 T7947 arg2Of IL-12,and
R6020 T7949 T7951 arg1Of We,investigated
R6021 T7951 T7950 arg1Of investigated,next
R6022 T7956 T7953 arg2Of activation,repeated
R6023 T7956 T7954 arg1Of activation,strong
R6024 T7956 T7955 arg1Of activation,TCR
R6025 T7956 T7957 arg1Of activation,is
R6026 T7957 T7951 arg2Of is,investigated
R6027 T7957 T7952 arg1Of is,whether
R6028 T7960 T7957 arg2Of signal,is
R6029 T7960 T7958 arg1Of signal,a
R6030 T7960 T7959 arg1Of signal,compensatory
R6031 T7960 T7961 arg1Of signal,for
R6032 T7964 T7961 arg2Of signaling,for
R6033 T7964 T7962 arg1Of signaling,IL-12-induced
R6034 T7964 T7963 arg1Of signaling,STAT4
R6035 T7964 T7965 arg1Of signaling,in
R6036 T7967 T7965 arg2Of induction,in
R6037 T7967 T7966 arg1Of induction,the
R6038 T7967 T7968 arg1Of induction,of
R6039 T7967 T7970 arg1Of induction,in
R6040 T7969 T7968 arg2Of IL-10,of
R6041 T7972 T7970 arg2Of cells,in
R6042 T7972 T7971 arg1Of cells,Th1
R6043 T7974 T7973 arg2Of this,For
R6044 T7977 T7976 arg1Of T cells,CD4+
R6045 T7977 T7978 arg1Of T cells,were
R6046 T7977 T7979 arg2Of T cells,differentiated
R6047 T7979 T7973 arg1Of differentiated,For
R6048 T7979 T7975 arg1Of differentiated,","
R6049 T7979 T7978 arg2Of differentiated,were
R6050 T7979 T7980 arg1Of differentiated,for
R6051 T7979 T7984 arg1Of differentiated,with
R6052 T7979 T7988 arg1Of differentiated,in
R6053 T7983 T7980 arg2Of weeks,for
R6054 T7983 T7981 arg1Of weeks,2
R6055 T7983 T7982 arg1Of weeks,consecutive
R6056 T7987 T7984 arg2Of doses,with
R6057 T7987 T7985 arg1Of doses,high
R6058 T7987 T7986 arg1Of doses,antigen
R6059 T7990 T7991 arg1Of presence,or
R6060 T7991 T7988 arg2Of or,in
R6061 T7991 T7989 arg1Of or,the
R6062 T7991 T7993 arg1Of or,of
R6063 T7991 T7995 arg1Of or,throughout
R6064 T7992 T7991 arg2Of absence,or
R6065 T7994 T7993 arg2Of IL-12,of
R6066 T7995 T7996 arg1Of throughout,(
R6067 T7998 T7996 arg2Of 4A–4D,(
R6068 T7998 T7997 arg1Of 4A–4D,Figures
R6069 T7999 T7996 arg3Of ),(
R6070 T8002 T8003 arg1Of dose,and
R6071 T8003 T8000 arg1Of and,High
R6072 T8003 T8001 arg1Of and,antigen
R6073 T8003 T8005 arg1Of and,cooperated
R6074 T8004 T8003 arg2Of IL-12,and
R6075 T8005 T8017 arg1Of cooperated,","
R6076 T8005 T8018 arg1Of cooperated,given
R6077 T8007 T8005 arg2Of induce,cooperated
R6078 T8007 T8006 arg1Of induce,to
R6079 T8010 T8007 arg2Of production,induce
R6080 T8010 T8008 arg1Of production,maximal
R6081 T8010 T8009 arg1Of production,IL-10
R6082 T8010 T8011 arg1Of production,(
R6083 T8013 T8014 arg1Of 4A,and
R6084 T8014 T8011 arg2Of and,(
R6085 T8014 T8012 arg1Of and,Figures
R6086 T8015 T8014 arg2Of 4B,and
R6087 T8016 T8011 arg3Of ),(
R6088 T8021 T8020 arg1Of combination,this
R6089 T8021 T8022 arg1Of combination,resulted
R6090 T8022 T8018 arg2Of resulted,given
R6091 T8022 T8019 arg1Of resulted,that
R6092 T8022 T8023 arg1Of resulted,in
R6093 T8026 T8023 arg2Of numbers,in
R6094 T8026 T8024 arg1Of numbers,the
R6095 T8026 T8025 arg1Of numbers,highest
R6096 T8026 T8027 arg1Of numbers,of
R6097 T8030 T8027 arg2Of cells,of
R6098 T8030 T8028 arg1Of cells,IL-10-producing
R6099 T8030 T8029 arg1Of cells,Th1
R6100 T8035 T8031 arg2Of stimulation,Repeated
R6101 T8035 T8032 arg1Of stimulation,high
R6102 T8035 T8033 arg1Of stimulation,antigen
R6103 T8035 T8034 arg1Of stimulation,dose
R6104 T8035 T8036 arg1Of stimulation,in
R6105 T8035 T8043 arg1Of stimulation,resulted
R6106 T8038 T8036 arg2Of absence,in
R6107 T8038 T8037 arg1Of absence,the
R6108 T8038 T8039 arg1Of absence,of
R6109 T8041 T8040 arg1Of added,exogenously
R6110 T8042 T8039 arg2Of IL-12,of
R6111 T8042 T8041 arg1Of IL-12,added
R6112 T8043 T8044 arg1Of resulted,in
R6113 T8043 T8052 arg1Of resulted,","
R6114 T8043 T8053 modOf resulted,suggesting
R6115 T8046 T8044 arg2Of production,in
R6116 T8046 T8045 arg1Of production,the
R6117 T8046 T8047 arg1Of production,of
R6118 T8046 T8049 arg1Of production,by
R6119 T8048 T8047 arg2Of IL-10,of
R6120 T8051 T8049 arg2Of cells,by
R6121 T8051 T8050 arg1Of cells,Th1
R6122 T8058 T8055 arg2Of triggering,repeated
R6123 T8058 T8056 arg1Of triggering,strong
R6124 T8058 T8057 arg1Of triggering,TCR
R6125 T8058 T8059 arg1Of triggering,may
R6126 T8058 T8060 arg1Of triggering,overcome
R6127 T8060 T8053 arg2Of overcome,suggesting
R6128 T8060 T8054 arg1Of overcome,that
R6129 T8060 T8059 arg2Of overcome,may
R6130 T8062 T8060 arg2Of need,overcome
R6131 T8062 T8061 arg1Of need,the
R6132 T8062 T8063 arg1Of need,for
R6133 T8064 T8063 arg2Of IL-12,for
R6134 T8064 T8065 arg1Of IL-12,for
R6135 T8067 T8065 arg2Of induction,for
R6136 T8067 T8066 arg1Of induction,IL-10
R6137 T8067 T8068 arg1Of induction,(
R6138 T8070 T8071 arg1Of 4C,and
R6139 T8071 T8068 arg2Of and,(
R6140 T8071 T8069 arg1Of and,Figures
R6141 T8072 T8071 arg2Of 4D,and
R6142 T8073 T8068 arg3Of ),(
R6143 T8077 T8076 arg1Of induction,IL-10
R6144 T8077 T8078 arg1Of induction,under
R6145 T8077 T8081 arg1Of induction,was
R6146 T8077 T8082 arg2Of induction,abrogated
R6147 T8080 T8078 arg2Of conditions,under
R6148 T8080 T8079 arg1Of conditions,these
R6149 T8082 T8074 arg1Of abrogated,However
R6150 T8082 T8075 arg1Of abrogated,","
R6151 T8082 T8081 arg2Of abrogated,was
R6152 T8082 T8083 arg1Of abrogated,when
R6153 T8085 T8084 arg1Of DCs,IL-12p40-deficient
R6154 T8085 T8086 arg1Of DCs,were
R6155 T8085 T8087 arg2Of DCs,used
R6156 T8087 T8083 arg2Of used,when
R6157 T8087 T8086 arg2Of used,were
R6158 T8087 T8088 arg1Of used,as
R6159 T8089 T8088 arg2Of APCs,as
R6160 T8089 T8090 arg1Of APCs,(
R6161 T8091 T8090 arg2Of Figure 4E,(
R6162 T8092 T8090 arg3Of ),(
R6163 T8095 T8096 arg1Of IL-12,is
R6164 T8095 T8097 arg1Of IL-12,essential
R6165 T8096 T8093 arg1Of is,Thus
R6166 T8096 T8094 arg1Of is,","
R6167 T8097 T8096 arg2Of essential,is
R6168 T8097 T8098 arg1Of essential,during
R6169 T8100 T8101 arg1Of primary,and
R6170 T8101 T8099 arg1Of and,both
R6171 T8102 T8101 arg2Of secondary,and
R6172 T8104 T8098 arg2Of stimulation,during
R6173 T8104 T8100 arg1Of stimulation,primary
R6174 T8104 T8102 arg1Of stimulation,secondary
R6175 T8104 T8103 arg1Of stimulation,antigenic
R6176 T8104 T8105 arg1Of stimulation,for
R6177 T8106 T8105 arg2Of production,for
R6178 T8106 T8107 arg1Of production,of
R6179 T8106 T8109 arg1Of production,by
R6180 T8108 T8107 arg2Of IL-10,of
R6181 T8111 T8109 arg2Of cells,by
R6182 T8111 T8110 arg1Of cells,Th1
R6183 T8113 T8112 arg1Of determine,To
R6184 T8115 T8113 arg2Of requirements,determine
R6185 T8115 T8114 arg1Of requirements,the
R6186 T8115 T8116 arg1Of requirements,for
R6187 T8117 T8116 arg2Of stability,for
R6188 T8117 T8118 arg1Of stability,of
R6189 T8122 T8118 arg2Of cells,of
R6190 T8122 T8119 arg1Of cells,the
R6191 T8122 T8120 arg1Of cells,IL-10-producing
R6192 T8122 T8121 arg1Of cells,Th1
R6193 T8124 T8113 arg1Of we,determine
R6194 T8124 T8125 arg1Of we,differentiated
R6195 T8124 T8146 arg1Of we,washed
R6196 T8124 T8151 arg1Of we,restimulated
R6197 T8125 T8128 arg1Of differentiated,for
R6198 T8125 T8131 arg1Of differentiated,with
R6199 T8125 T8145 arg1Of differentiated,","
R6200 T8127 T8125 arg2Of T cells,differentiated
R6201 T8127 T8126 arg1Of T cells,CD4+
R6202 T8130 T8128 arg2Of week,for
R6203 T8130 T8129 arg1Of week,1
R6204 T8134 T8131 arg2Of doses,with
R6205 T8134 T8132 arg1Of doses,high
R6206 T8134 T8133 arg1Of doses,antigen
R6207 T8134 T8135 arg1Of doses,with
R6208 T8134 T8137 arg1Of doses,without
R6209 T8135 T8136 arg1Of with,or
R6210 T8137 T8136 arg2Of without,or
R6211 T8138 T8135 arg2Of IL-12,with
R6212 T8138 T8137 arg2Of IL-12,without
R6213 T8138 T8139 arg1Of IL-12,(
R6214 T8141 T8142 arg1Of 4A,and
R6215 T8142 T8139 arg2Of and,(
R6216 T8142 T8140 arg1Of and,Figures
R6217 T8143 T8142 arg2Of 4C,and
R6218 T8144 T8139 arg3Of ),(
R6219 T8145 T8149 arg1Of ",",and
R6220 T8146 T8145 arg2Of washed,","
R6221 T8147 T8146 arg2Of them,washed
R6222 T8149 T8112 modOf and,To
R6223 T8149 T8123 arg1Of and,","
R6224 T8149 T8148 arg1Of and,","
R6225 T8151 T8149 arg2Of restimulated,and
R6226 T8151 T8150 arg1Of restimulated,then
R6227 T8151 T8153 arg1Of restimulated,for
R6228 T8151 T8157 arg1Of restimulated,with
R6229 T8151 T8162 arg1Of restimulated,","
R6230 T8151 T8163 arg1Of restimulated,in
R6231 T8152 T8151 arg2Of them,restimulated
R6232 T8156 T8153 arg2Of week,for
R6233 T8156 T8154 arg1Of week,an
R6234 T8156 T8155 arg1Of week,additional
R6235 T8161 T8157 arg2Of dose,with
R6236 T8161 T8158 arg1Of dose,a
R6237 T8161 T8159 arg1Of dose,low
R6238 T8161 T8160 arg1Of dose,antigen
R6239 T8165 T8166 arg1Of absence,or
R6240 T8166 T8163 arg2Of or,in
R6241 T8166 T8164 arg1Of or,the
R6242 T8166 T8168 arg1Of or,of
R6243 T8167 T8166 arg2Of presence,or
R6244 T8169 T8168 arg2Of IL-12,of
R6245 T8169 T8170 arg1Of IL-12,(
R6246 T8171 T8170 arg2Of Figure 4F,(
R6247 T8172 T8170 arg3Of ),(
R6248 T8174 T8173 arg1Of cells,Th1
R6249 T8174 T8175 arg2Of cells,induced
R6250 T8174 T8191 arg1Of cells,lost
R6251 T8175 T8176 arg1Of induced,in
R6252 T8175 T8180 modOf induced,to
R6253 T8179 T8176 arg2Of week,in
R6254 T8179 T8177 arg1Of week,the
R6255 T8179 T8178 arg1Of week,first
R6256 T8181 T8180 arg1Of produce,to
R6257 T8181 T8183 arg1Of produce,by
R6258 T8182 T8181 arg2Of IL-10,produce
R6259 T8184 T8183 arg2Of culture,by
R6260 T8184 T8185 arg1Of culture,with
R6261 T8188 T8186 arg1Of doses,high
R6262 T8188 T8187 arg1Of doses,antigen
R6263 T8188 T8189 arg1Of doses,and
R6264 T8189 T8185 arg2Of and,with
R6265 T8190 T8189 arg2Of IL-12,and
R6266 T8193 T8191 arg2Of ability,lost
R6267 T8193 T8192 arg1Of ability,their
R6268 T8193 T8194 modOf ability,to
R6269 T8193 T8204 arg1Of ability,","
R6270 T8193 T8205 arg1Of ability,which
R6271 T8193 T8206 arg1Of ability,could
R6272 T8193 T8207 arg1Of ability,be
R6273 T8193 T8208 arg2Of ability,compensated
R6274 T8195 T8194 arg1Of express,to
R6275 T8195 T8197 arg1Of express,when
R6276 T8196 T8195 arg2Of IL-10,express
R6277 T8198 T8197 arg2Of recultured,when
R6278 T8198 T8199 arg1Of recultured,with
R6279 T8201 T8199 arg2Of doses,with
R6280 T8201 T8200 arg1Of doses,low
R6281 T8201 T8202 arg1Of doses,of
R6282 T8203 T8202 arg2Of OVA,of
R6283 T8208 T8206 arg2Of compensated,could
R6284 T8208 T8207 arg2Of compensated,be
R6285 T8208 T8209 arg1Of compensated,for
R6286 T8208 T8211 arg1Of compensated,to
R6287 T8208 T8214 arg1Of compensated,","
R6288 T8208 T8215 arg1Of compensated,by
R6289 T8208 T8226 arg1Of compensated,","
R6290 T8208 T8228 modOf compensated,suggesting
R6291 T8209 T8210 arg1Of for,","
R6292 T8211 T8210 arg2Of to,","
R6293 T8213 T8211 arg2Of extent,to
R6294 T8213 T8212 arg1Of extent,some
R6295 T8216 T8215 arg2Of addition,by
R6296 T8216 T8217 arg1Of addition,of
R6297 T8216 T8219 arg1Of addition,to
R6298 T8218 T8217 arg2Of IL-12,of
R6299 T8222 T8219 arg2Of cultures,to
R6300 T8222 T8220 arg1Of cultures,the
R6301 T8222 T8221 arg1Of cultures,secondary
R6302 T8222 T8223 arg1Of cultures,(
R6303 T8224 T8223 arg2Of Figure 4F,(
R6304 T8225 T8223 arg3Of ),(
R6305 T8228 T8227 arg1Of suggesting,again
R6306 T8231 T8232 arg1Of dose,and
R6307 T8233 T8232 arg2Of IL-12,and
R6308 T8234 T8230 arg1Of signals,antigen
R6309 T8234 T8231 arg1Of signals,dose
R6310 T8234 T8233 arg1Of signals,IL-12
R6311 T8234 T8235 arg1Of signals,cooperate
R6312 T8235 T8228 arg2Of cooperate,suggesting
R6313 T8235 T8229 arg1Of cooperate,that
R6314 T8235 T8236 arg1Of cooperate,for
R6315 T8238 T8236 arg2Of induction,for
R6316 T8238 T8237 arg1Of induction,the
R6317 T8238 T8239 arg1Of induction,of
R6318 T8240 T8239 arg2Of IL-10,of
R6319 T8245 T8243 arg1Of cells,DO11.10
R6320 T8245 T8244 arg1Of cells,CD4+
R6321 T8245 T8246 arg1Of cells,that
R6322 T8245 T8247 arg1Of cells,were
R6323 T8245 T8248 arg2Of cells,exposed
R6324 T8245 T8261 arg1Of cells,produced
R6325 T8248 T8247 arg2Of exposed,were
R6326 T8248 T8249 arg1Of exposed,to
R6327 T8248 T8256 arg1Of exposed,during
R6328 T8251 T8249 arg2Of doses,to
R6329 T8251 T8250 arg1Of doses,low
R6330 T8251 T8252 arg1Of doses,of
R6331 T8253 T8254 arg1Of antigen,and
R6332 T8254 T8252 arg2Of and,of
R6333 T8255 T8254 arg2Of IL-12,and
R6334 T8260 T8256 arg2Of phase,during
R6335 T8260 T8257 arg1Of phase,the
R6336 T8260 T8258 arg1Of phase,primary
R6337 T8260 T8259 arg1Of phase,differentiation
R6338 T8261 T8270 arg1Of produced,but
R6339 T8263 T8261 arg2Of amounts,produced
R6340 T8263 T8262 arg1Of amounts,high
R6341 T8263 T8264 arg1Of amounts,of
R6342 T8265 T8266 arg1Of IFN-γ,but
R6343 T8267 T8266 arg2Of little,but
R6344 T8268 T8264 arg2Of IL-10,of
R6345 T8268 T8265 arg1Of IL-10,IFN-γ
R6346 T8268 T8267 arg1Of IL-10,little
R6347 T8270 T8241 arg1Of but,Finally
R6348 T8270 T8242 arg1Of but,","
R6349 T8270 T8269 arg1Of but,","
R6350 T8271 T8272 arg1Of they,could
R6351 T8271 T8273 arg1Of they,be
R6352 T8271 T8274 arg2Of they,induced
R6353 T8271 T8276 arg1Of they,produce
R6354 T8274 T8270 arg2Of induced,but
R6355 T8274 T8272 arg2Of induced,could
R6356 T8274 T8273 arg2Of induced,be
R6357 T8276 T8274 arg3Of produce,induced
R6358 T8276 T8275 arg1Of produce,to
R6359 T8276 T8278 arg1Of produce,when
R6360 T8277 T8276 arg2Of IL-10,produce
R6361 T8282 T8280 arg1Of dose,high
R6362 T8282 T8281 arg1Of dose,antigen
R6363 T8282 T8283 arg1Of dose,and
R6364 T8283 T8279 arg1Of and,both
R6365 T8283 T8285 arg1Of and,were
R6366 T8283 T8286 arg1Of and,present
R6367 T8284 T8283 arg2Of IL-12,and
R6368 T8285 T8278 arg2Of were,when
R6369 T8286 T8285 arg2Of present,were
R6370 T8286 T8287 arg1Of present,during
R6371 T8290 T8287 arg2Of phase,during
R6372 T8290 T8288 arg1Of phase,the
R6373 T8290 T8289 arg1Of phase,recall
R6374 T8290 T8291 arg1Of phase,(
R6375 T8292 T8291 arg2Of Figure S4,(
R6376 T8293 T8291 arg3Of ),(
R6377 T8298 T8299 arg1Of dose,and
R6378 T8299 T8296 arg1Of and,high
R6379 T8299 T8297 arg1Of and,antigen
R6380 T8299 T8301 arg1Of and,are
R6381 T8299 T8302 arg2Of and,required
R6382 T8300 T8299 arg2Of IL-12,and
R6383 T8302 T8294 arg1Of required,Thus
R6384 T8302 T8295 arg1Of required,","
R6385 T8302 T8301 arg2Of required,are
R6386 T8302 T8303 arg1Of required,for
R6387 T8304 T8303 arg2Of sustaining,for
R6388 T8306 T8304 arg2Of induction,sustaining
R6389 T8306 T8305 arg1Of induction,the
R6390 T8306 T8307 arg1Of induction,of
R6391 T8306 T8310 arg1Of induction,by
R6392 T8309 T8307 arg2Of production,of
R6393 T8309 T8308 arg1Of production,IL-10
R6394 T8312 T8310 arg2Of cells,by
R6395 T8312 T8311 arg1Of cells,Th1
R7166 T9393 T9392 arg1Of Production,IL-10
R7167 T9393 T9394 arg1Of Production,by
R7168 T9393 T9397 arg1Of Production,Requires
R7169 T9396 T9394 arg2Of Cells,by
R7170 T9396 T9395 arg1Of Cells,Th1
R7171 T9398 T9399 arg1Of ERK1,and
R7172 T9400 T9399 arg2Of ERK2,and
R7173 T9401 T9397 arg2Of Activation,Requires
R7174 T9401 T9398 arg1Of Activation,ERK1
R7175 T9401 T9400 arg1Of Activation,ERK2
R7176 T9403 T9402 arg1Of data,Our
R7177 T9403 T9404 arg1Of data,showed
R7178 T9407 T9406 arg1Of maintenance,the
R7179 T9407 T9408 arg1Of maintenance,of
R7180 T9407 T9411 arg1Of maintenance,in
R7181 T9407 T9414 arg1Of maintenance,required
R7182 T9410 T9408 arg2Of induction,of
R7183 T9410 T9409 arg1Of induction,IL-10
R7184 T9413 T9411 arg2Of cells,in
R7185 T9413 T9412 arg1Of cells,Th1
R7186 T9414 T9404 arg2Of required,showed
R7187 T9414 T9405 arg1Of required,that
R7188 T9415 T9414 arg2Of stimulation,required
R7189 T9415 T9416 arg1Of stimulation,with
R7190 T9419 T9416 arg2Of dose,with
R7191 T9419 T9417 arg1Of dose,high
R7192 T9419 T9418 arg1Of dose,antigen
R7193 T9419 T9420 arg1Of dose,","
R7194 T9419 T9421 arg1Of dose,which
R7195 T9419 T9425 arg1Of dose,could
R7196 T9419 T9426 arg1Of dose,be
R7197 T9419 T9427 arg2Of dose,compensated
R7198 T9424 T9422 arg2Of extent,to
R7199 T9424 T9423 arg1Of extent,some
R7200 T9427 T9422 arg1Of compensated,to
R7201 T9427 T9425 arg2Of compensated,could
R7202 T9427 T9426 arg2Of compensated,be
R7203 T9427 T9428 arg1Of compensated,for
R7204 T9427 T9429 arg1Of compensated,by
R7205 T9431 T9429 arg2Of addition,by
R7206 T9431 T9430 arg1Of addition,the
R7207 T9431 T9432 arg1Of addition,of
R7208 T9433 T9432 arg2Of IL-12,of
R7209 T9434 T9435 arg1Of Signaling,through
R7210 T9434 T9443 arg1Of Signaling,induced
R7211 T9437 T9435 arg2Of TCR,through
R7212 T9437 T9436 arg1Of TCR,the
R7213 T9437 T9438 arg1Of TCR,with
R7214 T9440 T9438 arg2Of doses,with
R7215 T9440 T9439 arg1Of doses,high
R7216 T9440 T9441 arg1Of doses,of
R7217 T9442 T9441 arg2Of antigen,of
R7218 T9443 T9459 arg1Of induced,in
R7219 T9443 T9468 arg1Of induced,as
R7220 T9443 T9479 arg1Of induced,in
R7221 T9445 T9444 arg1Of ERK1,stronger
R7222 T9445 T9446 arg1Of ERK1,and
R7223 T9446 T9443 arg2Of and,induced
R7224 T9446 T9449 arg1Of and,than
R7225 T9448 T9446 arg2Of activation,and
R7226 T9448 T9447 arg1Of activation,ERK2
R7227 T9450 T9449 arg2Of that,than
R7228 T9450 T9451 arg2Of that,induced
R7229 T9455 T9451 arg1Of dose,induced
R7230 T9455 T9452 arg2Of dose,by
R7231 T9455 T9453 arg1Of dose,low
R7232 T9455 T9454 arg1Of dose,antigen
R7233 T9458 T9456 arg1Of only,","
R7234 T9458 T9457 arg1Of only,not
R7235 T9459 T9458 arg1Of in,only
R7236 T9462 T9459 arg2Of T cells,in
R7237 T9462 T9460 arg1Of T cells,naive
R7238 T9462 T9461 arg1Of T cells,CD4+
R7239 T9462 T9463 arg1Of T cells,(
R7240 T9464 T9463 arg2Of data,(
R7241 T9464 T9466 arg2Of data,shown
R7242 T9466 T9465 arg1Of shown,not
R7243 T9467 T9463 arg3Of ),(
R7244 T9468 T9477 arg1Of as,but
R7245 T9470 T9469 arg1Of demonstrated,previously
R7246 T9473 T9468 arg2Of et al.,as
R7247 T9473 T9470 arg1Of et al.,demonstrated
R7248 T9473 T9471 arg2Of et al.,(
R7249 T9473 T9472 arg1Of et al.,Jorritsma
R7250 T9473 T9474 arg1Of et al.,","
R7251 T9475 T9474 arg2Of 2003,","
R7252 T9476 T9471 arg3Of ),(
R7253 T9477 T9478 arg1Of but,also
R7254 T9479 T9477 arg2Of in,but
R7255 T9481 T9479 arg2Of T cells,in
R7256 T9481 T9480 arg1Of T cells,CD4+
R7257 T9481 T9482 arg2Of T cells,restimulated
R7258 T9482 T9483 arg1Of restimulated,with
R7259 T9486 T9487 arg1Of high,and
R7260 T9488 T9487 arg2Of low,and
R7261 T9490 T9483 arg2Of doses,with
R7262 T9490 T9484 arg1Of doses,the
R7263 T9490 T9485 arg1Of doses,same
R7264 T9490 T9486 arg1Of doses,high
R7265 T9490 T9488 arg1Of doses,low
R7266 T9490 T9489 arg1Of doses,antigen
R7267 T9490 T9491 arg1Of doses,(
R7268 T9492 T9491 arg2Of Figure 5A,(
R7269 T9493 T9491 arg3Of ),(
R7270 T9497 T9498 arg1Of peak,and
R7271 T9498 T9495 arg1Of and,the
R7272 T9498 T9496 arg1Of and,apparent
R7273 T9498 T9500 arg1Of and,of
R7274 T9498 T9505 arg1Of and,varied
R7275 T9499 T9498 arg2Of amount,and
R7276 T9501 T9502 arg1Of ERK1,and
R7277 T9503 T9502 arg2Of ERK2,and
R7278 T9504 T9500 arg2Of activation,of
R7279 T9504 T9501 arg1Of activation,ERK1
R7280 T9504 T9503 arg1Of activation,ERK2
R7281 T9505 T9494 arg2Of varied,Although
R7282 T9505 T9506 arg1Of varied,slightly
R7283 T9505 T9507 arg1Of varied,between
R7284 T9508 T9507 arg2Of experiments,between
R7285 T9512 T9510 arg1Of finding,a
R7286 T9512 T9511 arg1Of finding,consistent
R7287 T9512 T9513 arg1Of finding,was
R7288 T9513 T9494 arg1Of was,Although
R7289 T9513 T9509 arg1Of was,","
R7290 T9517 T9515 arg1Of dose,high
R7291 T9517 T9516 arg1Of dose,antigen
R7292 T9517 T9518 arg1Of dose,differentiated
R7293 T9518 T9513 arg2Of differentiated,was
R7294 T9518 T9514 arg1Of differentiated,that
R7295 T9519 T9522 modOf Th1,showed
R7296 T9519 T9537 arg1Of Th1,of
R7297 T9520 T9522 arg1Of cells,showed
R7298 T9522 T9521 arg1Of showed,always
R7299 T9522 T9535 arg1Of showed,","
R7300 T9522 T9536 arg1Of showed,regardless
R7301 T9523 T9524 arg1Of enhanced,and
R7302 T9525 T9524 arg2Of prolonged,and
R7303 T9526 T9523 arg1Of ERK1,enhanced
R7304 T9526 T9525 arg1Of ERK1,prolonged
R7305 T9526 T9527 arg1Of ERK1,and
R7306 T9527 T9522 arg2Of and,showed
R7307 T9527 T9530 arg1Of and,in
R7308 T9529 T9527 arg2Of activation,and
R7309 T9529 T9528 arg1Of activation,ERK2
R7310 T9532 T9530 arg2Of presence,in
R7311 T9532 T9531 arg1Of presence,the
R7312 T9532 T9533 arg1Of presence,of
R7313 T9534 T9533 arg2Of IL-12,of
R7314 T9539 T9540 arg1Of they,were
R7315 T9539 T9541 arg2Of they,restimulated
R7316 T9541 T9537 arg2Of restimulated,of
R7317 T9541 T9538 arg1Of restimulated,whether
R7318 T9541 T9540 arg2Of restimulated,were
R7319 T9541 T9542 arg1Of restimulated,with
R7320 T9543 T9542 arg2Of high,with
R7321 T9547 T9518 arg2Of dose,differentiated
R7322 T9547 T9519 arg1Of dose,Th1
R7323 T9547 T9544 arg1Of dose,or
R7324 T9547 T9545 arg1Of dose,low
R7325 T9547 T9546 arg1Of dose,antigen
R7326 T9547 T9548 arg1Of dose,(
R7327 T9549 T9548 arg2Of Figure 5B,(
R7328 T9550 T9548 arg3Of ),(
R7329 T9551 T9553 arg1Of We,investigated
R7330 T9553 T9552 arg1Of investigated,then
R7331 T9555 T9556 arg1Of ERK1,and
R7332 T9557 T9556 arg2Of ERK2,and
R7333 T9558 T9555 arg1Of activation,ERK1
R7334 T9558 T9557 arg1Of activation,ERK2
R7335 T9558 T9559 arg1Of activation,was
R7336 T9558 T9560 arg2Of activation,required
R7337 T9558 T9570 arg1Of activation,using
R7338 T9560 T9553 arg2Of required,investigated
R7339 T9560 T9554 arg1Of required,whether
R7340 T9560 T9559 arg2Of required,was
R7341 T9560 T9561 arg1Of required,for
R7342 T9560 T9569 arg1Of required,by
R7343 T9563 T9561 arg2Of induction,for
R7344 T9563 T9562 arg1Of induction,the
R7345 T9563 T9564 arg1Of induction,of
R7346 T9563 T9566 arg1Of induction,in
R7347 T9565 T9564 arg2Of IL-10,of
R7348 T9568 T9566 arg2Of cells,in
R7349 T9568 T9567 arg1Of cells,Th1
R7350 T9570 T9569 arg2Of using,by
R7351 T9571 T9570 arg2Of U0126,using
R7352 T9571 T9572 arg1Of U0126,(
R7353 T9571 T9575 arg1Of U0126,","
R7354 T9573 T9572 arg2Of Figure 5C,(
R7355 T9574 T9572 arg3Of ),(
R7356 T9577 T9575 arg2Of compound,","
R7357 T9577 T9576 arg1Of compound,a
R7358 T9577 T9578 arg1Of compound,that
R7359 T9577 T9579 arg1Of compound,blocks
R7360 T9582 T9579 arg2Of activation,blocks
R7361 T9582 T9580 arg1Of activation,downstream
R7362 T9582 T9581 arg1Of activation,ERK
R7363 T9584 T9583 arg1Of ensure,To
R7364 T9588 T9586 arg1Of signaling,only
R7365 T9588 T9587 arg1Of signaling,T cell
R7366 T9588 T9589 arg1Of signaling,was
R7367 T9588 T9590 arg1Of signaling,being
R7368 T9588 T9591 arg2Of signaling,affected
R7369 T9591 T9584 arg2Of affected,ensure
R7370 T9591 T9585 arg1Of affected,that
R7371 T9591 T9589 arg2Of affected,was
R7372 T9591 T9590 arg2Of affected,being
R7373 T9593 T9591 arg1Of U0126,affected
R7374 T9593 T9592 arg2Of U0126,by
R7375 T9595 T9584 arg1Of we,ensure
R7376 T9595 T9596 arg1Of we,used
R7377 T9596 T9583 modOf used,To
R7378 T9596 T9594 arg1Of used,","
R7379 T9599 T9596 arg2Of system,used
R7380 T9599 T9597 arg1Of system,an
R7381 T9599 T9598 arg1Of system,APC-free
R7382 T9599 T9600 arg2Of system,in
R7383 T9599 T9601 arg1Of system,which
R7384 T9603 T9602 arg1Of T cells,the
R7385 T9603 T9604 arg1Of T cells,were
R7386 T9603 T9605 arg2Of T cells,differentiated
R7387 T9605 T9600 arg1Of differentiated,in
R7388 T9605 T9604 arg2Of differentiated,were
R7389 T9605 T9606 arg1Of differentiated,in
R7390 T9608 T9607 arg1Of presence,the
R7391 T9608 T9609 arg1Of presence,of
R7392 T9608 T9614 arg1Of presence,and
R7393 T9611 T9609 arg2Of doses,of
R7394 T9611 T9610 arg1Of doses,increasing
R7395 T9611 T9612 arg1Of doses,of
R7396 T9613 T9612 arg2Of anti-CD3,of
R7397 T9614 T9606 arg2Of and,in
R7398 T9617 T9614 arg2Of amount,and
R7399 T9617 T9615 arg1Of amount,a
R7400 T9617 T9616 arg1Of amount,constant
R7401 T9617 T9618 arg1Of amount,of
R7402 T9619 T9618 arg2Of IL-12,of
R7403 T9621 T9620 arg1Of in,As
R7404 T9624 T9621 arg2Of cultures,in
R7405 T9624 T9622 arg1Of cultures,the
R7406 T9624 T9623 arg1Of cultures,APC-driven
R7407 T9628 T9626 arg1Of stimulation,stronger
R7408 T9628 T9627 arg1Of stimulation,TCR
R7409 T9628 T9629 arg1Of stimulation,together
R7410 T9628 T9632 arg1Of stimulation,led
R7411 T9629 T9630 arg1Of together,with
R7412 T9631 T9630 arg2Of IL-12,with
R7413 T9632 T9621 arg1Of led,in
R7414 T9632 T9625 arg1Of led,","
R7415 T9632 T9633 arg1Of led,to
R7416 T9635 T9633 arg2Of percentages,to
R7417 T9635 T9634 arg1Of percentages,higher
R7418 T9635 T9636 arg1Of percentages,of
R7419 T9637 T9636 arg2Of cells,of
R7420 T9637 T9638 arg1Of cells,producing
R7421 T9638 T9643 arg1Of producing,after
R7422 T9640 T9641 arg1Of IL-10,and
R7423 T9641 T9638 arg2Of and,producing
R7424 T9641 T9639 arg1Of and,both
R7425 T9642 T9641 arg2Of IFN-γ,and
R7426 T9645 T9643 arg2Of week,after
R7427 T9645 T9644 arg1Of week,1
R7428 T9645 T9646 arg1Of week,of
R7429 T9647 T9646 arg2Of culture,of
R7430 T9647 T9648 arg1Of culture,(
R7431 T9649 T9648 arg2Of Figure 5C,(
R7432 T9650 T9648 arg3Of ),(
R7433 T9651 T9652 arg1Of Addition,of
R7434 T9651 T9654 arg1Of Addition,to
R7435 T9651 T9657 arg1Of Addition,abrogated
R7436 T9653 T9652 arg2Of U0126,of
R7437 T9656 T9654 arg2Of cultures,to
R7438 T9656 T9655 arg1Of cultures,the
R7439 T9659 T9657 arg2Of production,abrogated
R7440 T9659 T9658 arg1Of production,the
R7441 T9659 T9660 arg1Of production,of
R7442 T9659 T9662 arg1Of production,at
R7443 T9661 T9660 arg2Of IL-10,of
R7444 T9664 T9662 arg2Of doses,at
R7445 T9664 T9663 arg1Of doses,all
R7446 T9664 T9665 arg1Of doses,of
R7447 T9666 T9665 arg2Of anti-CD3,of
R7448 T9666 T9667 arg1Of anti-CD3,(
R7449 T9668 T9667 arg2Of Figure 5C,(
R7450 T9669 T9667 arg3Of ),(
R7451 T9671 T9672 arg1Of U0126,inhibits
R7452 T9672 T9670 arg2Of inhibits,Because
R7453 T9675 T9673 arg1Of activation,the
R7454 T9675 T9674 arg1Of activation,MEK5-catalyzed
R7455 T9675 T9676 arg1Of activation,of
R7456 T9675 T9681 arg1Of activation,as
R7457 T9677 T9676 arg2Of ERK5,of
R7458 T9681 T9672 arg2Of as,inhibits
R7459 T9681 T9678 arg1Of as,","
R7460 T9681 T9679 arg1Of as,as
R7461 T9681 T9680 arg1Of as,well
R7462 T9683 T9684 arg1Of MEK1-,and
R7463 T9684 T9681 arg2Of and,as
R7464 T9684 T9682 arg1Of and,the
R7465 T9686 T9684 arg2Of activation,and
R7466 T9686 T9685 arg1Of activation,MEK2-catalyzed
R7467 T9686 T9687 arg1Of activation,of
R7468 T9688 T9689 arg1Of ERK1,and
R7469 T9689 T9687 arg2Of and,of
R7470 T9689 T9691 arg1Of and,(
R7471 T9690 T9689 arg2Of ERK2,and
R7472 T9693 T9692 arg1Of et al.,Bain
R7473 T9693 T9694 arg1Of et al.,","
R7474 T9693 T9696 arg1Of et al.,;
R7475 T9695 T9694 arg2Of 2007,","
R7476 T9696 T9691 arg2Of ;,(
R7477 T9698 T9696 arg2Of et al.,;
R7478 T9698 T9697 arg1Of et al.,Mody
R7479 T9698 T9699 arg1Of et al.,","
R7480 T9700 T9699 arg2Of 2001,","
R7481 T9701 T9691 arg3Of ),(
R7482 T9703 T9705 arg1Of we,used
R7483 T9705 T9670 arg1Of used,Because
R7484 T9705 T9702 arg1Of used,","
R7485 T9705 T9704 arg1Of used,also
R7486 T9705 T9717 arg1Of used,at
R7487 T9708 T9707 arg1Of specific,more
R7488 T9708 T9709 arg1Of specific,","
R7489 T9711 T9709 arg2Of unrelated,","
R7490 T9711 T9710 arg1Of unrelated,structurally
R7491 T9712 T9713 arg1Of MEK1,and
R7492 T9713 T9705 arg2Of and,used
R7493 T9713 T9706 arg1Of and,the
R7494 T9713 T9708 arg1Of and,specific
R7495 T9713 T9711 arg1Of and,unrelated
R7496 T9716 T9713 arg2Of PD184352,and
R7497 T9716 T9714 arg1Of PD184352,MEK2
R7498 T9716 T9715 arg1Of PD184352,inhibitor
R7499 T9718 T9717 arg2Of concentrations,at
R7500 T9718 T9719 arg2Of concentrations,in
R7501 T9718 T9720 arg1Of concentrations,which
R7502 T9721 T9722 arg1Of it,inhibits
R7503 T9722 T9719 arg1Of inhibits,in
R7504 T9723 T9724 arg1Of MEK1,and
R7505 T9724 T9726 arg1Of and,but
R7506 T9725 T9724 arg2Of MEK2,and
R7507 T9726 T9722 arg2Of but,inhibits
R7508 T9726 T9727 arg1Of but,not
R7509 T9728 T9726 arg2Of MEK5,but
R7510 T9728 T9729 arg1Of MEK5,(
R7511 T9731 T9730 arg1Of et al.,Bain
R7512 T9731 T9732 arg1Of et al.,","
R7513 T9731 T9734 arg1Of et al.,;
R7514 T9733 T9732 arg2Of 2007,","
R7515 T9734 T9729 arg2Of ;,(
R7516 T9736 T9734 arg2Of et al.,;
R7517 T9736 T9735 arg1Of et al.,Mody
R7518 T9736 T9737 arg1Of et al.,","
R7519 T9738 T9737 arg2Of 2001,","
R7520 T9739 T9729 arg3Of ),(
R7521 T9740 T9741 arg1Of PD184352,caused
R7522 T9741 T9751 arg1Of caused,in
R7523 T9744 T9741 arg2Of inhibition,caused
R7524 T9744 T9742 arg1Of inhibition,a
R7525 T9744 T9743 arg1Of inhibition,similar
R7526 T9744 T9745 arg1Of inhibition,of
R7527 T9744 T9748 arg1Of inhibition,by
R7528 T9747 T9745 arg2Of production,of
R7529 T9747 T9746 arg1Of production,IL-10
R7530 T9750 T9748 arg2Of cells,by
R7531 T9750 T9749 arg1Of cells,Th1
R7532 T9754 T9751 arg2Of fashion,in
R7533 T9754 T9752 arg1Of fashion,a
R7534 T9754 T9753 arg1Of fashion,dose-dependent
R7535 T9754 T9755 arg1Of fashion,(
R7536 T9756 T9757 arg1Of Figure 5D,and
R7537 T9757 T9755 arg2Of and,(
R7538 T9758 T9757 arg2Of Figure S5A,and
R7539 T9759 T9755 arg3Of ),(
R7540 T9761 T9760 arg2Of addition,Upon
R7541 T9761 T9762 arg1Of addition,of
R7542 T9761 T9764 arg1Of addition,to
R7543 T9763 T9762 arg2Of inhibitors,of
R7544 T9766 T9764 arg2Of pathways,to
R7545 T9766 T9765 arg1Of pathways,other signaling
R7546 T9766 T9767 arg1Of pathways,","
R7547 T9766 T9768 arg1Of pathways,including
R7548 T9772 T9769 arg1Of inhibitor,a
R7549 T9772 T9770 arg1Of inhibitor,p38
R7550 T9772 T9771 arg1Of inhibitor,MAPK
R7551 T9772 T9773 arg1Of inhibitor,","
R7552 T9772 T9776 arg1Of inhibitor,or
R7553 T9774 T9773 arg2Of SB203580,","
R7554 T9776 T9768 arg2Of or,including
R7555 T9776 T9775 arg1Of or,","
R7556 T9779 T9776 arg2Of inhibitor,or
R7557 T9779 T9777 arg1Of inhibitor,the
R7558 T9779 T9778 arg1Of inhibitor,GSK3β
R7559 T9779 T9780 arg1Of inhibitor,","
R7560 T9781 T9780 arg2Of CT99021,","
R7561 T9781 T9782 arg1Of CT99021,(
R7562 T9784 T9782 arg2Of et al.,(
R7563 T9784 T9783 arg1Of et al.,Bain
R7564 T9784 T9785 arg1Of et al.,","
R7565 T9786 T9785 arg2Of 2007,","
R7566 T9787 T9782 arg3Of ),(
R7567 T9790 T9789 arg1Of effect,no
R7568 T9790 T9791 arg1Of effect,on
R7569 T9790 T9794 arg1Of effect,was
R7570 T9790 T9795 arg2Of effect,observed
R7571 T9793 T9791 arg2Of production,on
R7572 T9793 T9792 arg1Of production,IL-10
R7573 T9795 T9760 arg1Of observed,Upon
R7574 T9795 T9788 arg1Of observed,","
R7575 T9795 T9794 arg2Of observed,was
R7576 T9795 T9796 arg1Of observed,(
R7577 T9797 T9796 arg2Of Figure S5B,(
R7578 T9798 T9796 arg3Of ),(
R7579 T9800 T9799 arg1Of data,Our
R7580 T9800 T9802 arg1Of data,suggested
R7581 T9802 T9801 arg1Of suggested,thus
R7582 T9805 T9804 arg1Of production,IL-10
R7583 T9805 T9806 arg1Of production,by
R7584 T9805 T9817 arg1Of production,requires
R7585 T9808 T9806 arg2Of cells,by
R7586 T9808 T9807 arg1Of cells,Th1
R7587 T9808 T9809 arg1Of cells,in
R7588 T9810 T9809 arg2Of response,in
R7589 T9810 T9811 arg1Of response,to
R7590 T9814 T9812 arg1Of dose,high
R7591 T9814 T9813 arg1Of dose,antigen
R7592 T9814 T9815 arg1Of dose,and
R7593 T9815 T9811 arg2Of and,to
R7594 T9816 T9815 arg2Of IL-12,and
R7595 T9817 T9802 arg2Of requires,suggested
R7596 T9817 T9803 arg1Of requires,that
R7597 T9818 T9819 arg1Of ERK1,and
R7598 T9819 T9823 arg1Of and,but
R7599 T9821 T9819 arg2Of signaling,and
R7600 T9821 T9820 arg1Of signaling,ERK2
R7601 T9823 T9817 arg2Of but,requires
R7602 T9823 T9822 arg1Of but,","
R7603 T9823 T9824 arg1Of but,not
R7604 T9826 T9823 arg2Of activation,but
R7605 T9826 T9825 arg1Of activation,the
R7606 T9826 T9827 arg1Of activation,of
R7607 T9829 T9828 arg1Of p38,the
R7608 T9829 T9830 arg1Of p38,or
R7609 T9830 T9827 arg2Of or,of
R7610 T9833 T9830 arg2Of pathways,or
R7611 T9833 T9831 arg1Of pathways,the
R7612 T9833 T9832 arg1Of pathways,GSK3β
R8485 T11028 T11027 arg1Of Production,IL-10
R8486 T11028 T11029 arg1Of Production,by
R8487 T11028 T11035 arg1Of Production,Requires
R8488 T11030 T11031 arg1Of Th2,and
R8489 T11032 T11031 arg2Of Th17,and
R8490 T11033 T11029 arg2Of Cells,by
R8491 T11033 T11030 arg1Of Cells,Th2
R8492 T11033 T11032 arg1Of Cells,Th17
R8493 T11035 T11034 arg1Of Requires,Also
R8494 T11036 T11037 arg1Of ERK1,and
R8495 T11038 T11037 arg2Of ERK2,and
R8496 T11039 T11035 arg2Of Activation,Requires
R8497 T11039 T11036 arg1Of Activation,ERK1
R8498 T11039 T11038 arg1Of Activation,ERK2
R8499 T11041 T11040 arg1Of address,To
R8500 T11041 T11042 arg1Of address,whether
R8501 T11044 T11043 arg1Of production,IL-10
R8502 T11044 T11045 arg1Of production,by
R8503 T11044 T11050 arg1Of production,was
R8504 T11044 T11052 arg1Of production,dependent
R8505 T11046 T11047 arg1Of Th2,and
R8506 T11048 T11047 arg2Of Th17,and
R8507 T11049 T11045 arg2Of cells,by
R8508 T11049 T11046 arg1Of cells,Th2
R8509 T11049 T11048 arg1Of cells,Th17
R8510 T11050 T11042 arg2Of was,whether
R8511 T11050 T11051 arg1Of was,also
R8512 T11050 T11055 arg1Of was,and
R8513 T11052 T11050 arg2Of dependent,was
R8514 T11052 T11053 arg1Of dependent,on
R8515 T11054 T11053 arg2Of ERK1,on
R8516 T11056 T11041 arg2Of ERK2,address
R8517 T11057 T11041 arg1Of activation,address
R8518 T11057 T11058 arg1Of activation,","
R8519 T11057 T11060 arg1Of activation,differentiated
R8520 T11059 T11058 arg2Of we,","
R8521 T11060 T11040 modOf differentiated,To
R8522 T11060 T11063 arg1Of differentiated,with
R8523 T11060 T11067 arg1Of differentiated,in
R8524 T11060 T11088 arg1Of differentiated,","
R8525 T11060 T11089 arg1Of differentiated,in
R8526 T11062 T11060 arg2Of cells,differentiated
R8527 T11062 T11061 arg1Of cells,these
R8528 T11064 T11065 arg1Of anti-CD3,and
R8529 T11065 T11063 arg2Of and,with
R8530 T11066 T11065 arg2Of anti-CD28,and
R8531 T11069 T11067 arg2Of absence,in
R8532 T11069 T11068 arg1Of absence,the
R8533 T11069 T11070 arg1Of absence,of
R8534 T11071 T11070 arg2Of APCs,of
R8535 T11071 T11072 arg1Of APCs,(
R8536 T11074 T11073 arg1Of et al.,Shoemaker
R8537 T11074 T11075 arg1Of et al.,","
R8538 T11074 T11077 arg1Of et al.,;
R8539 T11076 T11075 arg2Of 2006,","
R8540 T11077 T11082 arg1Of ;,;
R8541 T11078 T11077 arg2Of Veldhoen,;
R8542 T11078 T11079 arg1Of Veldhoen,et al.
R8543 T11078 T11080 arg1Of Veldhoen,","
R8544 T11081 T11080 arg2Of 2009,","
R8545 T11082 T11072 arg2Of ;,(
R8546 T11083 T11082 arg2Of Veldhoen,;
R8547 T11083 T11084 arg1Of Veldhoen,et al.
R8548 T11083 T11085 arg1Of Veldhoen,","
R8549 T11086 T11085 arg2Of 2006,","
R8550 T11087 T11072 arg3Of ),(
R8551 T11091 T11092 arg1Of presence,or
R8552 T11092 T11089 arg2Of or,in
R8553 T11092 T11090 arg1Of or,the
R8554 T11092 T11094 arg1Of or,of
R8555 T11093 T11092 arg2Of absence,or
R8556 T11097 T11094 arg2Of inhibitor,of
R8557 T11097 T11095 arg1Of inhibitor,the
R8558 T11097 T11096 arg1Of inhibitor,MEK
R8559 T11097 T11098 arg1Of inhibitor,(
R8560 T11099 T11098 arg2Of PD184352,(
R8561 T11100 T11098 arg3Of ),(
R8562 T11101 T11102 arg1Of We,showed
R8563 T11104 T11105 arg1Of ERK1,and
R8564 T11105 T11108 arg1Of and,is
R8565 T11107 T11105 arg2Of activation,and
R8566 T11107 T11106 arg1Of activation,ERK2
R8567 T11108 T11102 arg2Of is,showed
R8568 T11108 T11103 arg1Of is,that
R8569 T11111 T11108 arg2Of pathway,is
R8570 T11111 T11109 arg1Of pathway,a
R8571 T11111 T11110 arg1Of pathway,common
R8572 T11111 T11112 arg2Of pathway,required
R8573 T11112 T11113 arg1Of required,for
R8574 T11112 T11122 arg1Of required,because
R8575 T11114 T11113 arg2Of induction,for
R8576 T11114 T11115 arg1Of induction,of
R8577 T11114 T11117 arg1Of induction,in
R8578 T11116 T11115 arg2Of IL-10,of
R8579 T11121 T11117 arg2Of subsets,in
R8580 T11121 T11118 arg1Of subsets,different
R8581 T11121 T11119 arg1Of subsets,Th
R8582 T11121 T11120 arg1Of subsets,cell
R8583 T11124 T11123 arg1Of production,IL-10
R8584 T11124 T11125 arg1Of production,by
R8585 T11124 T11131 arg1Of production,was
R8586 T11124 T11133 arg2Of production,inhibited
R8587 T11127 T11128 arg1Of Th2,and
R8588 T11128 T11126 arg1Of and,both
R8589 T11129 T11128 arg2Of Th17,and
R8590 T11130 T11125 arg2Of cells,by
R8591 T11130 T11127 arg1Of cells,Th2
R8592 T11130 T11129 arg1Of cells,Th17
R8593 T11133 T11122 arg2Of inhibited,because
R8594 T11133 T11131 arg2Of inhibited,was
R8595 T11133 T11132 arg1Of inhibited,markedly
R8596 T11133 T11134 arg1Of inhibited,in
R8597 T11136 T11134 arg2Of presence,in
R8598 T11136 T11135 arg1Of presence,the
R8599 T11136 T11137 arg1Of presence,of
R8600 T11140 T11137 arg2Of inhibitor,of
R8601 T11140 T11138 arg1Of inhibitor,the
R8602 T11140 T11139 arg1Of inhibitor,MEK
R8603 T11140 T11141 arg1Of inhibitor,(
R8604 T11140 T11144 arg1Of inhibitor,(
R8605 T11142 T11141 arg2Of PD184352,(
R8606 T11143 T11141 arg3Of ),(
R8607 T11145 T11146 arg1Of Figure 5D,and
R8608 T11146 T11144 arg2Of and,(
R8609 T11147 T11146 arg2Of Figure S5B,and
R8610 T11148 T11144 arg3Of ),(
R8611 T11150 T11149 arg2Of contrast,In
R8612 T11152 T11153 arg1Of inhibitors,of
R8613 T11152 T11157 arg1Of inhibitors,of
R8614 T11152 T11160 arg1Of inhibitors,did
R8615 T11152 T11162 arg1Of inhibitors,affect
R8616 T11153 T11156 arg1Of of,or
R8617 T11155 T11153 arg2Of MAPK,of
R8618 T11155 T11154 arg1Of MAPK,p38
R8619 T11157 T11156 arg2Of of,or
R8620 T11159 T11157 arg2Of activation,of
R8621 T11159 T11158 arg1Of activation,GSK-3β
R8622 T11162 T11149 arg1Of affect,In
R8623 T11162 T11151 arg1Of affect,","
R8624 T11162 T11160 arg2Of affect,did
R8625 T11162 T11161 arg1Of affect,not
R8626 T11164 T11162 arg2Of expression,affect
R8627 T11164 T11163 arg1Of expression,the
R8628 T11164 T11165 arg1Of expression,of
R8629 T11164 T11167 arg1Of expression,by
R8630 T11164 T11170 arg1Of expression,(
R8631 T11166 T11165 arg2Of IL-10,of
R8632 T11169 T11167 arg2Of subsets,by
R8633 T11169 T11168 arg1Of subsets,these
R8634 T11171 T11170 arg2Of Figure S5B,(
R8635 T11172 T11170 arg3Of ),(
R8636 T11173 T11174 arg1Of Activation,of
R8637 T11173 T11181 arg1Of Activation,is
R8638 T11176 T11177 arg1Of ERK1,and
R8639 T11178 T11177 arg2Of ERK2,and
R8640 T11180 T11174 arg2Of pathway,of
R8641 T11180 T11175 arg1Of pathway,the
R8642 T11180 T11176 arg1Of pathway,ERK1
R8643 T11180 T11178 arg1Of pathway,ERK2
R8644 T11180 T11179 arg1Of pathway,signaling
R8645 T11181 T11182 arg1Of is,therefore
R8646 T11185 T11181 arg2Of requirement,is
R8647 T11185 T11183 arg1Of requirement,a
R8648 T11185 T11184 arg1Of requirement,common
R8649 T11185 T11186 arg1Of requirement,for
R8650 T11188 T11186 arg2Of induction,for
R8651 T11188 T11187 arg1Of induction,the
R8652 T11188 T11189 arg1Of induction,of
R8653 T11188 T11192 arg1Of induction,by
R8654 T11191 T11189 arg2Of production,of
R8655 T11191 T11190 arg1Of production,IL-10
R8656 T11193 T11194 arg1Of Th1,","
R8657 T11194 T11197 arg1Of ",",and
R8658 T11195 T11194 arg2Of Th2,","
R8659 T11197 T11196 arg1Of and,","
R8660 T11198 T11197 arg2Of Th17,and
R8661 T11199 T11192 arg2Of cells,by
R8662 T11199 T11193 arg1Of cells,Th1
R8663 T11199 T11195 arg1Of cells,Th2
R8664 T11199 T11198 arg1Of cells,Th17
R9214 T11959 T11958 arg1Of Expression,c-maf
R9215 T11959 T11960 arg1Of Expression,Correlates
R9216 T11960 T11961 arg1Of Correlates,with
R9217 T11963 T11961 arg2Of Production,with
R9218 T11963 T11962 arg1Of Production,IL-10
R9219 T11963 T11964 arg1Of Production,in
R9220 T11965 T11966 arg1Of Th1,","
R9221 T11966 T11969 arg1Of ",",and
R9222 T11967 T11966 arg2Of Th2,","
R9223 T11969 T11968 arg1Of and,","
R9224 T11970 T11969 arg2Of Th17,and
R9225 T11971 T11964 arg2Of Cells,in
R9226 T11971 T11965 arg1Of Cells,Th1
R9227 T11971 T11967 arg1Of Cells,Th2
R9228 T11971 T11970 arg1Of Cells,Th17
R9229 T11973 T11972 arg1Of investigate,To
R9230 T11973 T11974 arg1Of investigate,further
R9231 T11977 T11973 arg2Of factors,investigate
R9232 T11977 T11975 arg1Of factors,the
R9233 T11977 T11976 arg1Of factors,downstream
R9234 T11977 T11978 arg2Of factors,involved
R9235 T11978 T11979 arg1Of involved,in
R9236 T11980 T11979 arg2Of regulating,in
R9237 T11982 T11980 arg2Of production,regulating
R9238 T11982 T11981 arg1Of production,IL-10
R9239 T11984 T11985 arg1Of we,differentiated
R9240 T11984 T12004 arg1Of we,quantified
R9241 T11985 T11994 arg1Of differentiated,","
R9242 T11985 T11995 arg1Of differentiated,in
R9243 T11985 T12003 arg1Of differentiated,and
R9244 T11988 T11985 arg2Of T cells,differentiated
R9245 T11988 T11986 arg1Of T cells,DO11.10
R9246 T11988 T11987 arg1Of T cells,CD4+
R9247 T11988 T11989 arg1Of T cells,with
R9248 T11991 T11989 arg2Of doses,with
R9249 T11991 T11990 arg1Of doses,increasing
R9250 T11991 T11992 arg1Of doses,of
R9251 T11993 T11992 arg2Of OVA,of
R9252 T11997 T11998 arg1Of presence,or
R9253 T11998 T11995 arg2Of or,in
R9254 T11998 T11996 arg1Of or,the
R9255 T11998 T12000 arg1Of or,of
R9256 T11999 T11998 arg2Of absence,or
R9257 T12001 T12000 arg2Of IL-12,of
R9258 T12003 T11972 modOf and,To
R9259 T12003 T11983 arg1Of and,","
R9260 T12003 T12002 arg1Of and,","
R9261 T12004 T12003 arg2Of quantified,and
R9262 T12004 T12012 arg1Of quantified,by
R9263 T12006 T12004 arg2Of expression,quantified
R9264 T12006 T12005 arg1Of expression,the
R9265 T12006 T12007 arg1Of expression,of
R9266 T12008 T12009 arg1Of cytokines,and
R9267 T12009 T12007 arg2Of and,of
R9268 T12011 T12009 arg2Of factors,and
R9269 T12011 T12010 arg1Of factors,transcription
R9270 T12014 T12012 arg2Of RT-PCR,by
R9271 T12014 T12013 arg1Of RT-PCR,real-time
R9272 T12016 T12015 arg1Of antigen,Low-dose
R9273 T12016 T12017 arg1Of antigen,resulted
R9274 T12017 T12018 arg1Of resulted,in
R9275 T12017 T12022 arg1Of resulted,and
R9276 T12019 T12018 arg2Of transcription,in
R9277 T12019 T12020 arg1Of transcription,of
R9278 T12021 T12020 arg2Of Il4,of
R9279 T12023 T12024 arg1Of this,was
R9280 T12023 T12025 arg2Of this,abrogated
R9281 T12025 T12022 arg2Of abrogated,and
R9282 T12025 T12024 arg2Of abrogated,was
R9283 T12030 T12028 arg1Of doses,high
R9284 T12030 T12029 arg1Of doses,antigen
R9285 T12030 T12031 arg1Of doses,and
R9286 T12031 T12025 arg1Of and,abrogated
R9287 T12031 T12026 arg2Of and,by
R9288 T12031 T12027 arg1Of and,both
R9289 T12032 T12031 arg2Of IL-12,and
R9290 T12032 T12033 arg1Of IL-12,(
R9291 T12034 T12033 arg2Of Figure 6A,(
R9292 T12035 T12033 arg3Of ),(
R9293 T12038 T12036 arg1Of amount,A
R9294 T12038 T12037 arg1Of amount,low
R9295 T12038 T12039 arg1Of amount,of
R9296 T12038 T12043 arg1Of amount,was
R9297 T12038 T12044 arg2Of amount,induced
R9298 T12040 T12039 arg2Of transcription,of
R9299 T12040 T12041 arg1Of transcription,of
R9300 T12042 T12041 arg2Of Ifnγ,of
R9301 T12044 T12043 arg2Of induced,was
R9302 T12044 T12045 arg1Of induced,by
R9303 T12044 T12047 arg1Of induced,when
R9304 T12044 T12056 arg1Of induced,but
R9305 T12046 T12045 arg2Of IL-12,by
R9306 T12048 T12049 arg1Of cells,were
R9307 T12048 T12050 arg2Of cells,differentiated
R9308 T12050 T12047 arg2Of differentiated,when
R9309 T12050 T12049 arg2Of differentiated,were
R9310 T12050 T12051 arg1Of differentiated,with
R9311 T12054 T12051 arg2Of dose,with
R9312 T12054 T12052 arg1Of dose,low
R9313 T12054 T12053 arg1Of dose,antigen
R9314 T12056 T12055 arg1Of but,","
R9315 T12058 T12057 arg1Of effect,this
R9316 T12058 T12059 arg1Of effect,of
R9317 T12058 T12061 arg1Of effect,was
R9318 T12058 T12063 arg2Of effect,upregulated
R9319 T12060 T12059 arg2Of IL-12,of
R9320 T12063 T12056 arg2Of upregulated,but
R9321 T12063 T12061 arg2Of upregulated,was
R9322 T12063 T12062 arg1Of upregulated,markedly
R9323 T12063 T12064 arg1Of upregulated,with
R9324 T12066 T12064 arg2Of doses,with
R9325 T12066 T12065 arg1Of doses,increasing
R9326 T12066 T12067 arg1Of doses,of
R9327 T12068 T12067 arg2Of antigen,of
R9328 T12068 T12069 arg1Of antigen,(
R9329 T12070 T12069 arg2Of Figure 6A,(
R9330 T12071 T12069 arg3Of ),(
R9331 T12074 T12072 arg1Of amount,A
R9332 T12074 T12073 arg1Of amount,low
R9333 T12074 T12075 arg1Of amount,of
R9334 T12074 T12078 arg1Of amount,was
R9335 T12074 T12079 arg2Of amount,observed
R9336 T12077 T12075 arg2Of transcription,of
R9337 T12077 T12076 arg1Of transcription,Il10
R9338 T12079 T12078 arg2Of observed,was
R9339 T12079 T12080 arg1Of observed,at
R9340 T12079 T12094 arg1Of observed,and
R9341 T12082 T12080 arg2Of doses,at
R9342 T12082 T12081 arg1Of doses,low
R9343 T12082 T12083 arg1Of doses,of
R9344 T12087 T12083 arg2Of expression,of
R9345 T12087 T12084 arg1Of expression,antigen
R9346 T12087 T12085 arg1Of expression,accompanying
R9347 T12087 T12086 arg1Of expression,Il4
R9348 T12087 T12088 arg1Of expression,(
R9349 T12091 T12088 arg2Of response,(
R9350 T12091 T12089 arg1Of response,Th2
R9351 T12091 T12090 arg1Of response,cell
R9352 T12092 T12088 arg3Of ),(
R9353 T12094 T12093 arg1Of and,","
R9354 T12095 T12096 arg1Of this,was
R9355 T12095 T12097 arg2Of this,abrogated
R9356 T12097 T12094 arg2Of abrogated,and
R9357 T12097 T12096 arg2Of abrogated,was
R9358 T12097 T12103 arg1Of abrogated,as
R9359 T12100 T12097 arg1Of doses,abrogated
R9360 T12100 T12098 arg2Of doses,by
R9361 T12100 T12099 arg2Of doses,increased
R9362 T12100 T12101 arg1Of doses,of
R9363 T12102 T12101 arg2Of antigen,of
R9364 T12104 T12103 arg2Of was,as
R9365 T12106 T12104 arg1Of expression,was
R9366 T12106 T12105 arg1Of expression,Il4
R9367 T12106 T12107 arg1Of expression,(
R9368 T12108 T12107 arg2Of Figure 6A,(
R9369 T12109 T12107 arg3Of ),(
R9370 T12112 T12110 arg2Of doses,At
R9371 T12112 T12111 arg1Of doses,low
R9372 T12112 T12113 arg1Of doses,of
R9373 T12114 T12113 arg2Of antigen,of
R9374 T12116 T12117 arg1Of IL-12,had
R9375 T12117 T12110 arg1Of had,At
R9376 T12117 T12115 arg1Of had,","
R9377 T12117 T12120 modOf had,to
R9378 T12119 T12117 arg2Of effect,had
R9379 T12119 T12118 arg1Of effect,little
R9380 T12121 T12120 arg1Of increase,to
R9381 T12124 T12121 arg2Of expression,increase
R9382 T12124 T12122 arg1Of expression,IL-10
R9383 T12124 T12123 arg1Of expression,mRNA
R9384 T12124 T12125 arg1Of expression,(
R9385 T12124 T12128 arg1Of expression,in
R9386 T12126 T12125 arg2Of Figure 6A,(
R9387 T12127 T12125 arg3Of ),(
R9388 T12129 T12128 arg2Of keeping,in
R9389 T12129 T12130 arg1Of keeping,with
R9390 T12133 T12130 arg2Of data,with
R9391 T12133 T12131 arg1Of data,the
R9392 T12133 T12132 arg1Of data,protein
R9393 T12133 T12134 arg1Of data,(
R9394 T12135 T12134 arg2Of Figure 1A,(
R9395 T12136 T12134 arg3Of ),(
R9396 T12139 T12140 arg1Of IL-12,induced
R9397 T12140 T12137 arg1Of induced,However
R9398 T12140 T12138 arg1Of induced,","
R9399 T12140 T12159 arg1Of induced,","
R9400 T12140 T12161 arg1Of induced,in
R9401 T12143 T12141 arg1Of amount,a
R9402 T12143 T12142 arg1Of amount,high
R9403 T12143 T12144 arg1Of amount,of
R9404 T12143 T12149 arg1Of amount,as
R9405 T12146 T12144 arg2Of transcription,of
R9406 T12146 T12145 arg1Of transcription,Il10
R9407 T12149 T12140 arg2Of as,induced
R9408 T12149 T12147 arg1Of as,as
R9409 T12149 T12148 arg1Of as,well
R9410 T12151 T12149 arg2Of expression,as
R9411 T12151 T12150 arg1Of expression,Ifnγ
R9412 T12151 T12152 arg1Of expression,with
R9413 T12155 T12152 arg2Of doses,with
R9414 T12155 T12153 arg2Of doses,increased
R9415 T12155 T12154 arg1Of doses,antigen
R9416 T12155 T12156 arg1Of doses,(
R9417 T12157 T12156 arg2Of Figure 6A,(
R9418 T12158 T12156 arg3Of ),(
R9419 T12161 T12160 arg1Of in,again
R9420 T12162 T12161 arg2Of keeping,in
R9421 T12162 T12163 arg1Of keeping,with
R9422 T12166 T12163 arg2Of data,with
R9423 T12166 T12164 arg1Of data,the
R9424 T12166 T12165 arg1Of data,protein
R9425 T12166 T12167 arg1Of data,(
R9426 T12168 T12167 arg2Of Figure 1A,(
R9427 T12169 T12167 arg3Of ),(
R9428 T12171 T12170 arg1Of T cells,CD4+
R9429 T12171 T12172 arg2Of T cells,differentiated
R9430 T12171 T12178 arg1Of T cells,did
R9431 T12171 T12180 arg1Of T cells,express
R9432 T12172 T12173 arg1Of differentiated,with
R9433 T12175 T12173 arg2Of doses,with
R9434 T12175 T12174 arg1Of doses,increasing
R9435 T12175 T12176 arg1Of doses,of
R9436 T12177 T12176 arg2Of antigen,of
R9437 T12180 T12178 arg2Of express,did
R9438 T12180 T12179 arg1Of express,not
R9439 T12180 T12189 arg1Of express,","
R9440 T12180 T12190 arg1Of express,unless
R9441 T12182 T12180 arg2Of amounts,express
R9442 T12182 T12181 arg1Of amounts,high
R9443 T12182 T12183 arg1Of amounts,of
R9444 T12186 T12185 arg2Of T-bet,(
R9445 T12187 T12185 arg3Of ),(
R9446 T12188 T12183 arg2Of mRNA,of
R9447 T12188 T12184 arg1Of mRNA,Tbx-21
R9448 T12188 T12185 arg1Of mRNA,(
R9449 T12191 T12192 arg1Of they,were
R9450 T12191 T12193 arg2Of they,cocultured
R9451 T12193 T12190 arg2Of cocultured,unless
R9452 T12193 T12192 arg2Of cocultured,were
R9453 T12193 T12194 arg1Of cocultured,with
R9454 T12195 T12194 arg2Of IL-12,with
R9455 T12195 T12196 arg1Of IL-12,(
R9456 T12197 T12196 arg2Of Figure 6B,(
R9457 T12198 T12196 arg3Of ),(
R9458 T12200 T12199 arg2Of contrast,In
R9459 T12203 T12202 arg1Of amounts,high
R9460 T12203 T12204 arg1Of amounts,of
R9461 T12203 T12208 arg1Of amounts,were
R9462 T12203 T12210 arg2Of amounts,observed
R9463 T12207 T12204 arg2Of expression,of
R9464 T12207 T12205 arg1Of expression,GATA-3
R9465 T12207 T12206 arg1Of expression,mRNA
R9466 T12210 T12208 arg2Of observed,were
R9467 T12210 T12209 arg1Of observed,only
R9468 T12210 T12211 arg1Of observed,under
R9469 T12210 T12224 arg1Of observed,and
R9470 T12215 T12211 arg2Of conditions,under
R9471 T12215 T12212 arg1Of conditions,Th2
R9472 T12215 T12213 arg1Of conditions,cell
R9473 T12215 T12214 arg1Of conditions,differentiation
R9474 T12215 T12216 arg1Of conditions,(
R9475 T12215 T12220 arg1Of conditions,(
R9476 T12218 T12216 arg2Of antigen,(
R9477 T12218 T12217 arg1Of antigen,low-dose
R9478 T12219 T12216 arg3Of ),(
R9479 T12221 T12220 arg2Of Figure 6B,(
R9480 T12222 T12220 arg3Of ),(
R9481 T12224 T12199 arg1Of and,In
R9482 T12224 T12201 arg1Of and,","
R9483 T12224 T12223 arg1Of and,","
R9484 T12226 T12225 arg1Of expression,this
R9485 T12226 T12227 arg1Of expression,was
R9486 T12226 T12229 arg2Of expression,downregulated
R9487 T12229 T12224 arg2Of downregulated,and
R9488 T12229 T12227 arg2Of downregulated,was
R9489 T12229 T12228 arg1Of downregulated,markedly
R9490 T12234 T12232 arg1Of dose,increasing
R9491 T12234 T12233 arg1Of dose,antigen
R9492 T12234 T12235 arg1Of dose,and
R9493 T12235 T12229 arg1Of and,downregulated
R9494 T12235 T12230 arg2Of and,by
R9495 T12235 T12231 arg1Of and,both
R9496 T12235 T12237 arg1Of and,in
R9497 T12236 T12235 arg2Of coculture,and
R9498 T12238 T12237 arg2Of IL-12,in
R9499 T12238 T12239 arg1Of IL-12,(
R9500 T12240 T12239 arg2Of Figure 6B,(
R9501 T12241 T12239 arg3Of ),(
R9502 T12242 T12243 arg1Of Differentiation,of
R9503 T12242 T12245 arg1Of Differentiation,under
R9504 T12242 T12249 arg1Of Differentiation,led
R9505 T12244 T12243 arg2Of T cells,of
R9506 T12248 T12245 arg2Of dose,under
R9507 T12248 T12246 arg1Of dose,low
R9508 T12248 T12247 arg1Of dose,antigen
R9509 T12249 T12250 arg1Of led,to
R9510 T12249 T12254 arg1Of led,","
R9511 T12249 T12255 arg1Of led,in
R9512 T12251 T12250 arg2Of expression,to
R9513 T12251 T12252 arg1Of expression,of
R9514 T12253 T12252 arg2Of c-maf,of
R9515 T12256 T12255 arg2Of keeping,in
R9516 T12256 T12257 arg1Of keeping,with
R9517 T12261 T12257 arg2Of profile,with
R9518 T12261 T12258 arg1Of profile,the
R9519 T12261 T12259 arg1Of profile,Th2
R9520 T12261 T12260 arg1Of profile,cell
R9521 T12261 T12262 arg1Of profile,(
R9522 T12261 T12268 arg1Of profile,","
R9523 T12261 T12269 arg1Of profile,which
R9524 T12261 T12270 arg1Of profile,was
R9525 T12261 T12273 arg2Of profile,abrogated
R9526 T12264 T12262 arg2Of et al.,(
R9527 T12264 T12263 arg1Of et al.,Ho
R9528 T12264 T12265 arg1Of et al.,","
R9529 T12266 T12265 arg2Of 1996,","
R9530 T12267 T12262 arg3Of ),(
R9531 T12272 T12271 arg1Of completely,almost
R9532 T12273 T12270 arg2Of abrogated,was
R9533 T12273 T12272 arg1Of abrogated,completely
R9534 T12276 T12273 arg1Of doses,abrogated
R9535 T12276 T12274 arg2Of doses,by
R9536 T12276 T12275 arg1Of doses,increasing
R9537 T12276 T12277 arg1Of doses,of
R9538 T12278 T12277 arg2Of antigen,of
R9539 T12278 T12279 arg1Of antigen,(
R9540 T12280 T12279 arg2Of Figure 6B,(
R9541 T12281 T12279 arg3Of ),(
R9542 T12284 T12285 arg1Of IL-12,sustained
R9543 T12285 T12282 arg1Of sustained,Interestingly
R9544 T12285 T12283 arg1Of sustained,","
R9545 T12285 T12293 arg1Of sustained,at
R9546 T12288 T12285 arg2Of expression,sustained
R9547 T12288 T12286 arg1Of expression,the
R9548 T12288 T12287 arg1Of expression,high
R9549 T12288 T12289 arg1Of expression,of
R9550 T12291 T12289 arg2Of mRNA,of
R9551 T12291 T12290 arg1Of mRNA,c-Maf
R9552 T12293 T12292 arg1Of at,even
R9553 T12297 T12293 arg2Of dose,at
R9554 T12297 T12294 arg1Of dose,the
R9555 T12297 T12295 arg1Of dose,highest
R9556 T12297 T12296 arg1Of dose,antigen
R9557 T12297 T12298 arg1Of dose,(
R9558 T12299 T12298 arg2Of Figure 6B,(
R9559 T12300 T12298 arg3Of ),(
R9560 T12304 T12303 arg1Of maintenance,IL-12
R9561 T12304 T12305 arg1Of maintenance,of
R9562 T12304 T12308 arg1Of maintenance,required
R9563 T12307 T12305 arg2Of expression,of
R9564 T12307 T12306 arg1Of expression,c-maf
R9565 T12308 T12301 arg1Of required,Moreover
R9566 T12308 T12302 arg1Of required,","
R9567 T12310 T12308 arg2Of activation,required
R9568 T12310 T12309 arg1Of activation,STAT4
R9569 T12310 T12311 arg1Of activation,(
R9570 T12312 T12311 arg2Of data,(
R9571 T12312 T12314 arg2Of data,shown
R9572 T12314 T12313 arg1Of shown,not
R9573 T12315 T12311 arg3Of ),(
R9574 T12318 T12316 arg2Of cells,In
R9575 T12318 T12317 arg1Of cells,Th17
R9576 T12319 T12320 arg1Of that,expressed
R9577 T12319 T12335 arg1Of that,were
R9578 T12319 T12336 arg1Of that,undetectable
R9579 T12320 T12316 arg1Of expressed,In
R9580 T12321 T12324 arg1Of IL-17a,as
R9581 T12324 T12320 arg2Of as,expressed
R9582 T12324 T12322 arg1Of as,as
R9583 T12324 T12323 arg1Of as,well
R9584 T12326 T12325 arg1Of mRNA,IL-10
R9585 T12326 T12327 arg1Of mRNA,(
R9586 T12326 T12330 arg1Of mRNA,","
R9587 T12328 T12327 arg2Of Figure 6C,(
R9588 T12329 T12327 arg3Of ),(
R9589 T12330 T12332 arg1Of ",",and
R9590 T12331 T12330 arg2Of T-bet,","
R9591 T12332 T12324 arg2Of and,as
R9592 T12334 T12332 arg2Of mRNA,and
R9593 T12334 T12333 arg1Of mRNA,GATA-3
R9594 T12335 T12342 arg1Of were,","
R9595 T12335 T12343 arg1Of were,whereas
R9596 T12335 T12352 arg1Of were,(
R9597 T12336 T12335 arg2Of undetectable,were
R9598 T12336 T12337 arg1Of undetectable,(
R9599 T12338 T12337 arg2Of data,(
R9600 T12338 T12340 arg2Of data,shown
R9601 T12340 T12339 arg1Of shown,not
R9602 T12341 T12337 arg3Of ),(
R9603 T12344 T12345 arg1Of that,of
R9604 T12344 T12347 arg1Of that,was
R9605 T12344 T12348 arg1Of that,high
R9606 T12346 T12345 arg2Of ROR-γt,of
R9607 T12347 T12343 arg2Of was,whereas
R9608 T12348 T12347 arg2Of high,was
R9609 T12348 T12349 arg1Of high,(
R9610 T12350 T12349 arg2Of Figure 6C,(
R9611 T12351 T12349 arg3Of ),(
R9612 T12354 T12352 arg2Of et al.,(
R9613 T12354 T12353 arg1Of et al.,Ivanov
R9614 T12354 T12355 arg1Of et al.,","
R9615 T12356 T12355 arg2Of 2007,","
R9616 T12357 T12352 arg3Of ),(
R9617 T12359 T12358 arg1Of cells,Th17
R9618 T12359 T12361 arg1Of cells,expressed
R9619 T12359 T12370 arg1Of cells,confirming
R9620 T12361 T12360 arg1Of expressed,also
R9621 T12361 T12369 arg1Of expressed,","
R9622 T12361 T12370 modOf expressed,confirming
R9623 T12363 T12361 arg2Of amounts,expressed
R9624 T12363 T12362 arg1Of amounts,high
R9625 T12363 T12364 arg1Of amounts,of
R9626 T12365 T12364 arg2Of c-maf,of
R9627 T12365 T12366 arg1Of c-maf,(
R9628 T12367 T12366 arg2Of Figure 6C,(
R9629 T12368 T12366 arg3Of ),(
R9630 T12370 T12373 arg1Of confirming,report
R9631 T12373 T12371 arg1Of report,a
R9632 T12373 T12372 arg1Of report,recent
R9633 T12373 T12374 arg1Of report,(
R9634 T12376 T12374 arg2Of et al.,(
R9635 T12376 T12375 arg1Of et al.,Bauquet
R9636 T12376 T12377 arg1Of et al.,","
R9637 T12378 T12377 arg2Of 2009,","
R9638 T12379 T12374 arg3Of ),(
R9639 T12380 T12381 arg1Of . c-M,af
R9640 T12380 T12383 arg2Of . c-M,ore expre
R9641 T12380 T12397 arg1Of . c-M,6B
R9642 T12380 T12399 arg1Of . c-M,6C
R9643 T12383 T12381 arg2Of ore expre,af
R9644 T12383 T12382 arg1Of ore expre,is theref
R9645 T12383 T12384 arg1Of ore expre,ss
R9646 T12383 T12396 arg1Of ore expre,es
R9647 T12388 T12384 arg2Of g T cell po,ss
R9648 T12388 T12385 arg1Of g T cell po,ed
R9649 T12388 T12386 arg1Of g T cell po,in all IL-10-exp
R9650 T12388 T12387 arg1Of g T cell po,ressin
R9651 T12388 T12389 arg2Of g T cell po,pulati
R9652 T12388 T12390 arg1Of g T cell po,o
R9653 T12392 T12393 arg1Of ed,(Fi
R9654 T12393 T12390 arg2Of (Fi,o
R9655 T12393 T12391 arg1Of (Fi,ns test
R9656 T12394 T12393 arg2Of gu,(Fi
R9657 T12395 T12390 arg3Of r,o
R9658 T12396 T12370 arg2Of es ,confirming
R9659 T12396 T12409 arg1Of es ,a
R9660 T12399 T12396 arg2Of 6C,es
R9661 T12399 T12397 arg2Of 6C,6B
R9662 T12399 T12398 arg1Of 6C,and
R9663 T12405 T12399 arg2Of ific t,6C
R9664 T12405 T12400 arg1Of ific t,) an
R9665 T12405 T12401 arg1Of ific t,d
R9666 T12405 T12402 arg1Of ific t,may
R9667 T12405 T12403 arg1Of ific t,not be just a
R9668 T12405 T12404 arg1Of ific t,Th2 cell-spec
R9669 T12405 T12406 arg1Of ific t,ra
R9670 T12408 T12406 arg2Of factor ,ra
R9671 T12408 T12407 arg1Of factor ,nscription
R9672 T12411 T12409 arg2Of origin,a
R9673 T12411 T12410 arg1Of origin,s
R9674 T12411 T12412 arg1Of origin,a
R9675 T12413 T12412 arg2Of lly ,a
R9676 T12414 T12409 arg3Of t,a
R9677 T12415 T12416 arg1Of We,showed
R9678 T12416 T12417 arg1Of showed,also
R9679 T12421 T12419 arg2Of expression,like
R9680 T12421 T12420 arg1Of expression,Il10
R9681 T12424 T12423 arg1Of expression,c-maf
R9682 T12424 T12425 arg1Of expression,was
R9683 T12424 T12426 arg2Of expression,inhibited
R9684 T12426 T12416 arg2Of inhibited,showed
R9685 T12426 T12418 arg1Of inhibited,that
R9686 T12426 T12419 arg1Of inhibited,like
R9687 T12426 T12422 arg1Of inhibited,","
R9688 T12426 T12425 arg2Of inhibited,was
R9689 T12426 T12427 arg1Of inhibited,in
R9690 T12426 T12432 arg1Of inhibited,in
R9691 T12426 T12444 arg1Of inhibited,","
R9692 T12426 T12445 arg1Of inhibited,whereas
R9693 T12428 T12429 arg1Of Th1,and
R9694 T12430 T12429 arg2Of Th17,and
R9695 T12431 T12427 arg2Of cells,in
R9696 T12431 T12428 arg1Of cells,Th1
R9697 T12431 T12430 arg1Of cells,Th17
R9698 T12434 T12432 arg2Of presence,in
R9699 T12434 T12433 arg1Of presence,the
R9700 T12434 T12435 arg1Of presence,of
R9701 T12437 T12438 arg1Of MEK1,and
R9702 T12439 T12438 arg2Of MEK2,and
R9703 T12440 T12435 arg2Of inhibitor,of
R9704 T12440 T12436 arg1Of inhibitor,the
R9705 T12440 T12437 arg1Of inhibitor,MEK1
R9706 T12440 T12439 arg1Of inhibitor,MEK2
R9707 T12440 T12441 arg1Of inhibitor,(
R9708 T12442 T12441 arg2Of PD184352,(
R9709 T12443 T12441 arg3Of ),(
R9710 T12446 T12447 arg1Of T-bet,and
R9711 T12448 T12447 arg2Of RORγt,and
R9712 T12449 T12446 arg1Of expression,T-bet
R9713 T12449 T12448 arg1Of expression,RORγt
R9714 T12449 T12450 arg1Of expression,was
R9715 T12449 T12452 arg2Of expression,affected
R9716 T12452 T12445 arg2Of affected,whereas
R9717 T12452 T12450 arg2Of affected,was
R9718 T12452 T12451 arg1Of affected,hardly
R9719 T12452 T12453 arg1Of affected,(
R9720 T12454 T12453 arg2Of Figure 6D,(
R9721 T12455 T12453 arg3Of ),(
R10993 T14234 T14233 arg1Of expression,IL-10
R10994 T14234 T14235 arg1Of expression,by
R10995 T14234 T14244 arg1Of expression,reflects
R10996 T14236 T14235 arg2Of cells,by
R10997 T14236 T14237 arg1Of cells,of
R10998 T14239 T14240 arg1Of innate,and
R10999 T14241 T14240 arg2Of adaptive,and
R11000 T14243 T14237 arg2Of systems,of
R11001 T14243 T14238 arg1Of systems,the
R11002 T14243 T14239 arg1Of systems,innate
R11003 T14243 T14241 arg1Of systems,adaptive
R11004 T14243 T14242 arg1Of systems,immune
R11005 T14244 T14258 arg1Of reflects,","
R11006 T14244 T14259 modOf reflects,to
R11007 T14246 T14244 arg2Of importance,reflects
R11008 T14246 T14245 arg1Of importance,the
R11009 T14246 T14247 arg1Of importance,of
R11010 T14249 T14247 arg2Of cytokine,of
R11011 T14249 T14248 arg1Of cytokine,this
R11012 T14249 T14250 arg1Of cytokine,in
R11013 T14253 T14250 arg2Of regulation,in
R11014 T14253 T14251 arg1Of regulation,the
R11015 T14253 T14252 arg1Of regulation,tight
R11016 T14253 T14254 arg1Of regulation,of
R11017 T14257 T14254 arg2Of response,of
R11018 T14257 T14255 arg1Of response,the
R11019 T14257 T14256 arg1Of response,immune
R11020 T14260 T14259 arg1Of minimize,to
R11021 T14260 T14262 arg1Of minimize,during
R11022 T14261 T14260 arg2Of pathology,minimize
R11023 T14263 T14262 arg2Of infection,during
R11024 T14265 T14264 arg1Of expression,IL-10
R11025 T14265 T14266 arg1Of expression,by
R11026 T14265 T14269 arg1Of expression,has
R11027 T14265 T14270 arg1Of expression,been
R11028 T14265 T14271 arg2Of expression,reported
R11029 T14265 T14273 arg1Of expression,regulate
R11030 T14268 T14266 arg2Of cells,by
R11031 T14268 T14267 arg1Of cells,Th1
R11032 T14271 T14269 arg2Of reported,has
R11033 T14271 T14270 arg2Of reported,been
R11034 T14273 T14271 arg3Of regulate,reported
R11035 T14273 T14272 arg1Of regulate,to
R11036 T14276 T14273 arg2Of response,regulate
R11037 T14276 T14274 arg1Of response,the
R11038 T14276 T14275 arg1Of response,immune
R11039 T14276 T14277 arg1Of response,in
R11040 T14278 T14279 arg1Of leishmaniasis,and
R11041 T14279 T14277 arg2Of and,in
R11042 T14280 T14279 arg2Of toxoplasmosis,and
R11043 T14285 T14283 arg2Of situations,in
R11044 T14285 T14284 arg1Of situations,many
R11045 T14287 T14288 arg1Of IL-10,is
R11046 T14287 T14290 arg2Of IL-10,produced
R11047 T14290 T14281 arg1Of produced,However
R11048 T14290 T14282 arg1Of produced,","
R11049 T14290 T14283 arg1Of produced,in
R11050 T14290 T14286 arg1Of produced,","
R11051 T14290 T14288 arg2Of produced,is
R11052 T14290 T14289 arg1Of produced,not
R11053 T14290 T14294 arg1Of produced,in
R11054 T14293 T14290 arg1Of cells,produced
R11055 T14293 T14291 arg2Of cells,by
R11056 T14293 T14292 arg1Of cells,Th1
R11057 T14295 T14294 arg2Of response,in
R11058 T14295 T14296 arg1Of response,to
R11059 T14298 T14296 arg2Of stimulation,to
R11060 T14298 T14297 arg1Of stimulation,antigenic
R11061 T14300 T14299 arg1Of goal,Our
R11062 T14300 T14301 arg1Of goal,was
R11063 T14303 T14301 arg2Of address,was
R11064 T14303 T14302 arg1Of address,to
R11065 T14306 T14303 arg2Of signals,address
R11066 T14306 T14304 arg1Of signals,the
R11067 T14306 T14305 arg1Of signals,molecular
R11068 T14306 T14307 arg1Of signals,that
R11069 T14306 T14308 arg1Of signals,determine
R11070 T14311 T14310 arg1Of cells,Th1
R11071 T14311 T14312 arg1Of cells,develop
R11072 T14311 T14314 arg1Of cells,produce
R11073 T14312 T14308 arg2Of develop,determine
R11074 T14312 T14309 arg1Of develop,whether
R11075 T14312 T14313 modOf develop,to
R11076 T14312 T14316 arg1Of develop,(
R11077 T14314 T14313 arg1Of produce,to
R11078 T14315 T14314 arg2Of IL-10,produce
R11079 T14317 T14316 arg2Of Trinchieri,(
R11080 T14317 T14318 arg1Of Trinchieri,","
R11081 T14317 T14319 arg1Of Trinchieri,2007
R11082 T14320 T14316 arg3Of ),(
R11083 T14323 T14324 arg1Of we,showed
R11084 T14324 T14321 arg1Of showed,Here
R11085 T14324 T14322 arg1Of showed,","
R11086 T14327 T14326 arg1Of cells,Th1
R11087 T14327 T14328 arg1Of cells,required
R11088 T14328 T14324 arg2Of required,showed
R11089 T14328 T14325 arg1Of required,that
R11090 T14330 T14329 arg1Of ERK1,high-antigen-dose-induced
R11091 T14330 T14331 arg1Of ERK1,and
R11092 T14331 T14334 arg1Of and,and
R11093 T14333 T14331 arg2Of phosphorylation,and
R11094 T14333 T14332 arg1Of phosphorylation,ERK2
R11095 T14334 T14328 arg2Of and,required
R11096 T14337 T14334 arg2Of activation,and
R11097 T14337 T14335 arg1Of activation,IL-12-induced
R11098 T14337 T14336 arg1Of activation,STAT-4
R11099 T14337 T14338 modOf activation,to
R11100 T14339 T14338 arg1Of produce,to
R11101 T14340 T14339 arg2Of IL-10,produce
R11102 T14342 T14341 arg1Of findings,Our
R11103 T14342 T14352 arg2Of findings,required
R11104 T14342 T14373 arg1Of findings,","
R11105 T14342 T14374 arg1Of findings,such
R11106 T14344 T14345 arg1Of ERK1,and
R11107 T14345 T14348 arg1Of and,was
R11108 T14347 T14345 arg2Of activation,and
R11109 T14347 T14346 arg1Of activation,ERK2
R11110 T14348 T14342 arg2Of was,findings
R11111 T14348 T14343 arg1Of was,that
R11112 T14351 T14348 arg2Of pathway,was
R11113 T14351 T14349 arg1Of pathway,a
R11114 T14351 T14350 arg1Of pathway,common
R11115 T14352 T14353 arg1Of required,for
R11116 T14355 T14353 arg2Of production,for
R11117 T14355 T14354 arg1Of production,the
R11118 T14355 T14356 arg1Of production,of
R11119 T14357 T14356 arg2Of IL-10,of
R11120 T14357 T14358 arg1Of IL-10,by
R11121 T14359 T14360 arg1Of Th1,","
R11122 T14360 T14363 arg1Of ",",and
R11123 T14361 T14360 arg2Of Th2,","
R11124 T14363 T14362 arg1Of and,","
R11125 T14364 T14363 arg2Of Th17,and
R11126 T14366 T14358 arg2Of subsets,by
R11127 T14366 T14359 arg1Of subsets,Th1
R11128 T14366 T14361 arg1Of subsets,Th2
R11129 T14366 T14364 arg1Of subsets,Th17
R11130 T14366 T14365 arg1Of subsets,cell
R11131 T14366 T14367 arg1Of subsets,","
R11132 T14366 T14368 arg1Of subsets,which
R11133 T14366 T14369 arg1Of subsets,differentiate
R11134 T14369 T14370 arg1Of differentiate,along
R11135 T14372 T14370 arg2Of pathways,along
R11136 T14372 T14371 arg1Of pathways,distinct
R11137 T14376 T14377 arg1Of IL-10,provides
R11138 T14376 T14384 arg1Of IL-10,avoid
R11139 T14376 T14395 arg1Of IL-10,allow
R11140 T14377 T14383 modOf provides,to
R11141 T14377 T14393 arg1Of provides,and
R11142 T14380 T14379 arg1Of regulated,highly
R11143 T14382 T14377 arg2Of loop,provides
R11144 T14382 T14378 arg1Of loop,a
R11145 T14382 T14380 arg1Of loop,regulated
R11146 T14382 T14381 arg1Of loop,feedback
R11147 T14384 T14383 arg1Of avoid,to
R11148 T14386 T14384 arg2Of extremes,avoid
R11149 T14386 T14385 arg1Of extremes,the
R11150 T14386 T14387 arg1Of extremes,of
R11151 T14389 T14388 arg1Of inflammation,excessive
R11152 T14389 T14390 arg1Of inflammation,or
R11153 T14390 T14387 arg2Of or,of
R11154 T14392 T14390 arg2Of infections,or
R11155 T14392 T14391 arg1Of infections,chronic
R11156 T14393 T14374 arg2Of and,such
R11157 T14393 T14375 arg1Of and,that
R11158 T14395 T14393 arg2Of allow,and
R11159 T14395 T14394 arg1Of allow,also
R11160 T14398 T14395 arg2Of response,allow
R11161 T14398 T14396 arg1Of response,a
R11162 T14398 T14397 arg1Of response,protective
R11163 T14398 T14399 arg1Of response,to
R11164 T14401 T14399 arg2Of pathogens,to
R11165 T14401 T14400 arg1Of pathogens,diverse
R11166 T14404 T14405 arg1Of viral,or
R11167 T14406 T14405 arg2Of parasitic,or
R11168 T14407 T14402 arg2Of infections,In
R11169 T14407 T14403 arg1Of infections,certain
R11170 T14407 T14404 arg1Of infections,viral
R11171 T14407 T14406 arg1Of infections,parasitic
R11172 T14407 T14408 arg1Of infections,(
R11173 T14410 T14409 arg1Of et al.,Anderson
R11174 T14410 T14411 arg1Of et al.,","
R11175 T14410 T14413 arg1Of et al.,;
R11176 T14412 T14411 arg2Of 2007,","
R11177 T14413 T14418 arg1Of ;,;
R11178 T14414 T14413 arg2Of Brooks,;
R11179 T14414 T14415 arg1Of Brooks,et al.
R11180 T14414 T14416 arg1Of Brooks,","
R11181 T14417 T14416 arg2Of 2006,","
R11182 T14418 T14408 arg2Of ;,(
R11183 T14420 T14418 arg2Of et al.,;
R11184 T14420 T14419 arg1Of et al.,Ejrnaes
R11185 T14420 T14421 arg1Of et al.,","
R11186 T14422 T14421 arg2Of 2006,","
R11187 T14423 T14408 arg3Of ),(
R11188 T14426 T14425 arg1Of amounts,high
R11189 T14426 T14427 arg1Of amounts,of
R11190 T14426 T14429 arg1Of amounts,may
R11191 T14426 T14430 arg1Of amounts,lead
R11192 T14428 T14427 arg2Of stimulation,of
R11193 T14430 T14402 arg1Of lead,In
R11194 T14430 T14424 arg1Of lead,","
R11195 T14430 T14429 arg2Of lead,may
R11196 T14430 T14431 arg1Of lead,to
R11197 T14434 T14433 arg1Of nonhealing,chronic
R11198 T14435 T14431 arg2Of infection,to
R11199 T14435 T14432 arg1Of infection,the
R11200 T14435 T14434 arg1Of infection,nonhealing
R11201 T14435 T14436 arg2Of infection,shown
R11202 T14435 T14438 arg1Of infection,be
R11203 T14435 T14439 arg2Of infection,regulated
R11204 T14439 T14436 arg3Of regulated,shown
R11205 T14439 T14437 arg1Of regulated,to
R11206 T14439 T14438 arg2Of regulated,be
R11207 T14441 T14439 arg1Of IL-10,regulated
R11208 T14441 T14440 arg2Of IL-10,by
R11209 T14444 T14442 arg2Of course,During
R11210 T14444 T14443 arg1Of course,the
R11211 T14444 T14445 arg1Of course,of
R11212 T14446 T14445 arg2Of infection,of
R11213 T14450 T14448 arg2Of triggering,after
R11214 T14450 T14449 arg1Of triggering,initial
R11215 T14450 T14451 arg1Of triggering,with
R11216 T14452 T14451 arg2Of antigen,with
R11217 T14454 T14455 arg1Of T cells,migrate
R11218 T14455 T14442 arg1Of migrate,During
R11219 T14455 T14447 arg1Of migrate,","
R11220 T14455 T14448 arg1Of migrate,after
R11221 T14455 T14453 arg1Of migrate,","
R11222 T14455 T14456 arg1Of migrate,to
R11223 T14458 T14456 arg2Of tissue,to
R11224 T14458 T14457 arg1Of tissue,the
R11225 T14458 T14459 arg1Of tissue,encountering
R11226 T14461 T14460 arg1Of doses,high
R11227 T14461 T14462 arg1Of doses,of
R11228 T14461 T14464 arg1Of doses,and
R11229 T14463 T14462 arg2Of antigen,of
R11230 T14464 T14459 arg2Of and,encountering
R11231 T14465 T14464 arg2Of factors,and
R11232 T14465 T14466 arg2Of factors,produced
R11233 T14471 T14466 arg1Of response,produced
R11234 T14471 T14467 arg2Of response,by
R11235 T14471 T14468 arg1Of response,the
R11236 T14471 T14469 arg1Of response,innate
R11237 T14471 T14470 arg1Of response,immune
R11238 T14474 T14472 arg2Of conditions,Under
R11239 T14474 T14473 arg1Of conditions,these
R11240 T14476 T14477 arg1Of we,speculate
R11241 T14477 T14472 arg1Of speculate,Under
R11242 T14477 T14475 arg1Of speculate,","
R11243 T14480 T14479 arg1Of cells,Th1
R11244 T14480 T14481 arg1Of cells,will
R11245 T14480 T14482 arg1Of cells,be
R11246 T14480 T14483 arg2Of cells,induced
R11247 T14480 T14485 arg1Of cells,express
R11248 T14483 T14477 arg2Of induced,speculate
R11249 T14483 T14478 arg1Of induced,that
R11250 T14483 T14481 arg2Of induced,will
R11251 T14483 T14482 arg2Of induced,be
R11252 T14485 T14483 arg3Of express,induced
R11253 T14485 T14484 arg1Of express,to
R11254 T14485 T14490 arg1Of express,","
R11255 T14485 T14491 arg1Of express,in
R11256 T14487 T14485 arg2Of amounts,express
R11257 T14487 T14486 arg1Of amounts,high
R11258 T14487 T14488 arg1Of amounts,of
R11259 T14489 T14488 arg2Of IL-10,of
R11260 T14492 T14491 arg2Of keeping,in
R11261 T14492 T14493 arg1Of keeping,with
R11262 T14494 T14507 arg1Of reports,but
R11263 T14498 T14496 arg1Of cells,IL-10-producing
R11264 T14498 T14497 arg1Of cells,Th1
R11265 T14498 T14499 arg1Of cells,were
R11266 T14498 T14500 arg2Of cells,found
R11267 T14500 T14494 arg2Of found,reports
R11268 T14500 T14495 arg1Of found,that
R11269 T14500 T14499 arg2Of found,were
R11270 T14500 T14501 arg1Of found,in
R11271 T14503 T14501 arg2Of clones,in
R11272 T14503 T14502 arg1Of clones,CD4+
R11273 T14503 T14504 arg2Of clones,isolated
R11274 T14504 T14505 arg1Of isolated,from
R11275 T14506 T14505 arg2Of BAL,from
R11276 T14507 T14493 arg2Of but,with
R11277 T14507 T14508 arg1Of but,not
R11278 T14509 T14507 arg2Of blood,but
R11279 T14509 T14510 arg1Of blood,of
R11280 T14509 T14513 arg1Of blood,(
R11281 T14512 T14510 arg2Of patients,of
R11282 T14512 T14511 arg1Of patients,TB
R11283 T14515 T14513 arg2Of et al.,(
R11284 T14515 T14514 arg1Of et al.,Gerosa
R11285 T14515 T14516 arg1Of et al.,","
R11286 T14517 T14516 arg2Of 1999,","
R11287 T14518 T14513 arg3Of ),(
R11288 T14523 T14521 arg1Of response,the
R11289 T14523 T14522 arg1Of response,immune
R11290 T14523 T14524 arg1Of response,to
R11291 T14523 T14531 arg1Of response,","
R11292 T14523 T14532 arg1Of response,which
R11293 T14523 T14533 arg1Of response,produces
R11294 T14523 T14539 arg1Of response,was
R11295 T14523 T14540 arg2Of response,found
R11296 T14523 T14542 arg1Of response,be
R11297 T14523 T14543 arg2Of response,regulated
R11298 T14527 T14524 arg2Of isolate,to
R11299 T14527 T14525 arg1Of isolate,a
R11300 T14527 T14526 arg1Of isolate,clinical
R11301 T14527 T14528 arg1Of isolate,of
R11302 T14529 T14528 arg2Of L.,of
R11303 T14529 T14530 arg1Of L.,major
R11304 T14535 T14534 arg1Of infected,heavily
R11305 T14537 T14533 arg2Of lesions,produces
R11306 T14537 T14535 arg1Of lesions,infected
R11307 T14537 T14536 arg1Of lesions,nonhealing
R11308 T14540 T14538 arg1Of found,","
R11309 T14540 T14539 arg2Of found,was
R11310 T14540 T14563 arg1Of found,and
R11311 T14543 T14540 arg3Of regulated,found
R11312 T14543 T14541 arg1Of regulated,to
R11313 T14543 T14542 arg2Of regulated,be
R11314 T14545 T14543 arg1Of IL-10,regulated
R11315 T14545 T14544 arg2Of IL-10,by
R11316 T14545 T14546 arg2Of IL-10,derived
R11317 T14546 T14547 arg1Of derived,from
R11318 T14550 T14547 arg2Of cells,from
R11319 T14550 T14548 arg1Of cells,Foxp3−
R11320 T14550 T14549 arg1Of cells,Th1
R11321 T14550 T14551 arg1Of cells,that
R11322 T14550 T14552 arg1Of cells,coproduce
R11323 T14553 T14554 arg1Of IL-10,and
R11324 T14554 T14552 arg2Of and,coproduce
R11325 T14554 T14556 arg1Of and,(
R11326 T14555 T14554 arg2Of IFN-γ,and
R11327 T14558 T14556 arg2Of et al.,(
R11328 T14558 T14557 arg1Of et al.,Anderson
R11329 T14558 T14559 arg1Of et al.,","
R11330 T14560 T14559 arg2Of 2007,","
R11331 T14561 T14556 arg3Of ),(
R11332 T14563 T14519 arg1Of and,Similarly
R11333 T14563 T14520 arg1Of and,","
R11334 T14563 T14562 arg1Of and,","
R11335 T14566 T14564 arg1Of response,the
R11336 T14566 T14565 arg1Of response,immune
R11337 T14566 T14567 arg1Of response,during
R11338 T14566 T14571 arg1Of response,was
R11339 T14566 T14572 arg2Of response,found
R11340 T14566 T14575 arg1Of response,be
R11341 T14566 T14576 arg2Of response,regulated
R11342 T14570 T14567 arg2Of infection,during
R11343 T14570 T14568 arg1Of infection,T.
R11344 T14570 T14569 arg1Of infection,gondii
R11345 T14572 T14563 arg2Of found,and
R11346 T14572 T14571 arg2Of found,was
R11347 T14576 T14572 arg3Of regulated,found
R11348 T14576 T14573 arg1Of regulated,also
R11349 T14576 T14574 arg1Of regulated,to
R11350 T14576 T14575 arg2Of regulated,be
R11351 T14580 T14576 arg1Of cells,regulated
R11352 T14580 T14577 arg2Of cells,by
R11353 T14580 T14578 arg1Of cells,Foxp3−
R11354 T14580 T14579 arg1Of cells,Th1
R11355 T14580 T14581 arg1Of cells,(
R11356 T14583 T14581 arg2Of et al.,(
R11357 T14583 T14582 arg1Of et al.,Jankovic
R11358 T14583 T14584 arg1Of et al.,","
R11359 T14585 T14584 arg2Of 2007,","
R11360 T14586 T14581 arg3Of ),(
R11361 T14587 T14588 arg1Of It,is
R11362 T14587 T14589 arg1Of It,likely
R11363 T14588 T14607 arg1Of is,whereas
R11364 T14589 T14588 arg2Of likely,is
R11365 T14592 T14591 arg1Of production,IL-10
R11366 T14592 T14593 arg1Of production,by
R11367 T14592 T14596 arg1Of production,is
R11368 T14592 T14597 arg2Of production,evoked
R11369 T14595 T14593 arg2Of cells,by
R11370 T14595 T14594 arg1Of cells,Th1
R11371 T14597 T14589 arg2Of evoked,likely
R11372 T14597 T14590 arg1Of evoked,that
R11373 T14597 T14596 arg2Of evoked,is
R11374 T14597 T14598 arg1Of evoked,under
R11375 T14599 T14598 arg2Of conditions,under
R11376 T14599 T14600 arg1Of conditions,of
R11377 T14602 T14601 arg1Of inflammation,high
R11378 T14602 T14603 arg1Of inflammation,and
R11379 T14603 T14600 arg2Of and,of
R11380 T14605 T14603 arg2Of stimulation,and
R11381 T14605 T14604 arg1Of stimulation,antigenic
R11382 T14607 T14606 arg1Of whereas,","
R11383 T14610 T14608 arg1Of T cells,regulatory
R11384 T14610 T14609 arg1Of T cells,CD4+
R11385 T14610 T14611 arg1Of T cells,producing
R11386 T14610 T14613 arg1Of T cells,may
R11387 T14610 T14614 arg1Of T cells,operate
R11388 T14610 T14616 arg1Of T cells,regulate
R11389 T14612 T14611 arg2Of IL-10,producing
R11390 T14614 T14607 arg2Of operate,whereas
R11391 T14614 T14613 arg2Of operate,may
R11392 T14614 T14615 modOf operate,to
R11393 T14616 T14615 arg1Of regulate,to
R11394 T14619 T14616 arg2Of response,regulate
R11395 T14619 T14617 arg1Of response,the
R11396 T14619 T14618 arg1Of response,immune
R11397 T14619 T14620 arg1Of response,under
R11398 T14621 T14620 arg2Of conditions,under
R11399 T14621 T14622 arg2Of conditions,in
R11400 T14621 T14623 arg1Of conditions,which
R11401 T14621 T14629 arg1Of conditions,","
R11402 T14621 T14634 arg1Of conditions,with
R11403 T14621 T14641 arg1Of conditions,(
R11404 T14625 T14624 arg1Of pathogen,the
R11405 T14625 T14626 arg1Of pathogen,is
R11406 T14625 T14628 arg2Of pathogen,controlled
R11407 T14628 T14622 arg1Of controlled,in
R11408 T14628 T14626 arg2Of controlled,is
R11409 T14628 T14627 arg1Of controlled,clinically
R11410 T14630 T14632 arg1Of such,in
R11411 T14632 T14631 arg1Of in,as
R11412 T14633 T14632 arg2Of infection,in
R11413 T14634 T14630 arg1Of with,such
R11414 T14636 T14634 arg2Of major,with
R11415 T14636 T14635 arg1Of major,L.
R11416 T14636 T14637 arg1Of major,(
R11417 T14639 T14637 arg2Of strain,(
R11418 T14639 T14638 arg1Of strain,Friedlin
R11419 T14640 T14637 arg3Of ),(
R11420 T14643 T14642 arg1Of et al.,Belkaid
R11421 T14643 T14644 arg1Of et al.,","
R11422 T14643 T14646 arg1Of et al.,;
R11423 T14645 T14644 arg2Of 2002,","
R11424 T14646 T14641 arg2Of ;,(
R11425 T14647 T14646 arg2Of Suffia,;
R11426 T14647 T14648 arg1Of Suffia,et al.
R11427 T14647 T14649 arg1Of Suffia,","
R11428 T14650 T14649 arg2Of 2006,","
R11429 T14651 T14641 arg3Of ),(
R11430 T14652 T14655 arg1Of We,reported
R11431 T14655 T14653 arg1Of reported,now
R11432 T14655 T14654 arg1Of reported,also
R11433 T14658 T14657 arg1Of T cells,CD4+
R11434 T14658 T14659 arg2Of T cells,cultured
R11435 T14658 T14666 arg1Of T cells,differentiate
R11436 T14659 T14660 arg1Of cultured,with
R11437 T14663 T14661 arg1Of dose,high
R11438 T14663 T14662 arg1Of dose,antigen
R11439 T14663 T14664 arg1Of dose,and
R11440 T14664 T14660 arg2Of and,with
R11441 T14665 T14664 arg2Of IL-12,and
R11442 T14666 T14655 arg2Of differentiate,reported
R11443 T14666 T14656 arg1Of differentiate,that
R11444 T14666 T14667 arg1Of differentiate,into
R11445 T14671 T14667 arg2Of cells,into
R11446 T14671 T14668 arg1Of cells,canonical
R11447 T14671 T14669 arg1Of cells,Th1
R11448 T14671 T14670 arg1Of cells,effector
R11449 T14671 T14672 arg1Of cells,","
R11450 T14671 T14673 arg1Of cells,which
R11451 T14671 T14686 arg1Of cells,lose
R11452 T14676 T14675 arg2Of addition,in
R11453 T14676 T14677 arg1Of addition,to
R11454 T14678 T14677 arg2Of expressing,to
R11455 T14680 T14678 arg2Of amounts,expressing
R11456 T14680 T14679 arg1Of amounts,large
R11457 T14680 T14681 arg1Of amounts,of
R11458 T14682 T14683 arg1Of IFN-γ,and
R11459 T14683 T14681 arg2Of and,of
R11460 T14684 T14683 arg2Of IL-10,and
R11461 T14686 T14674 arg1Of lose,","
R11462 T14686 T14675 arg1Of lose,in
R11463 T14686 T14685 arg1Of lose,","
R11464 T14686 T14690 arg1Of lose,as
R11465 T14689 T14686 arg2Of expression,lose
R11466 T14689 T14687 arg1Of expression,their
R11467 T14689 T14688 arg1Of expression,IL-2
R11468 T14691 T14690 arg2Of described,as
R11469 T14691 T14692 arg1Of described,before
R11470 T14691 T14693 arg1Of described,in
R11471 T14697 T14693 arg2Of models,in
R11472 T14697 T14694 arg1Of models,certain
R11473 T14697 T14695 arg1Of models,chronic
R11474 T14697 T14696 arg1Of models,infection
R11475 T14697 T14698 arg1Of models,(
R11476 T14700 T14698 arg2Of et al.,(
R11477 T14700 T14699 arg1Of et al.,Sallusto
R11478 T14700 T14701 arg1Of et al.,","
R11479 T14702 T14701 arg2Of 2004,","
R11480 T14703 T14698 arg3Of ),(
R11481 T14705 T14704 arg1Of demonstration,Our
R11482 T14705 T14716 arg1Of demonstration,offers
R11483 T14707 T14708 arg1Of loss,of
R11484 T14707 T14710 arg1Of loss,is
R11485 T14707 T14711 arg2Of loss,accompanied
R11486 T14709 T14708 arg2Of IL-2,of
R11487 T14711 T14705 arg2Of accompanied,demonstration
R11488 T14711 T14706 arg1Of accompanied,that
R11489 T14711 T14710 arg2Of accompanied,is
R11490 T14713 T14711 arg1Of production,accompanied
R11491 T14713 T14712 arg2Of production,by
R11492 T14713 T14714 arg1Of production,of
R11493 T14715 T14714 arg2Of IL-10,of
R11494 T14719 T14716 arg2Of mechanisms,offers
R11495 T14719 T14717 arg1Of mechanisms,potential
R11496 T14719 T14718 arg1Of mechanisms,additional
R11497 T14719 T14720 arg1Of mechanisms,whereby
R11498 T14723 T14721 arg1Of responses,effector
R11499 T14723 T14722 arg1Of responses,T cell
R11500 T14723 T14724 arg1Of responses,may
R11501 T14723 T14725 arg1Of responses,be
R11502 T14723 T14726 arg2Of responses,dampened
R11503 T14726 T14720 arg2Of dampened,whereby
R11504 T14726 T14724 arg2Of dampened,may
R11505 T14726 T14725 arg2Of dampened,be
R11506 T14726 T14727 arg1Of dampened,during
R11507 T14729 T14727 arg2Of disease,during
R11508 T14729 T14728 arg1Of disease,chronic
R11509 T14734 T14730 arg2Of model,Using
R11510 T14734 T14731 arg1Of model,an
R11511 T14734 T14732 arg1Of model,in vivo
R11512 T14734 T14733 arg1Of model,transfer
R11513 T14734 T14735 arg1Of model,of
R11514 T14739 T14735 arg2Of cells,of
R11515 T14739 T14736 arg1Of cells,DO11.10
R11516 T14739 T14737 arg1Of cells,TCR
R11517 T14739 T14738 arg1Of cells,transgenic
R11518 T14739 T14740 arg1Of cells,(
R11519 T14741 T14740 arg2Of Castro,(
R11520 T14741 T14742 arg1Of Castro,et al.
R11521 T14741 T14743 arg1Of Castro,","
R11522 T14744 T14743 arg2Of 2000,","
R11523 T14745 T14740 arg3Of ),(
R11524 T14747 T14730 arg1Of we,Using
R11525 T14747 T14748 arg1Of we,showed
R11526 T14748 T14730 modOf showed,Using
R11527 T14748 T14746 arg1Of showed,","
R11528 T14752 T14750 arg1Of cells,IL-10-producing
R11529 T14752 T14751 arg1Of cells,Th1
R11530 T14752 T14753 arg1Of cells,were
R11531 T14752 T14754 arg2Of cells,differentiated
R11532 T14754 T14748 arg2Of differentiated,showed
R11533 T14754 T14749 arg1Of differentiated,that
R11534 T14754 T14753 arg2Of differentiated,were
R11535 T14754 T14755 arg1Of differentiated,in
R11536 T14757 T14755 arg2Of presence,in
R11537 T14757 T14756 arg1Of presence,the
R11538 T14757 T14758 arg1Of presence,of
R11539 T14760 T14758 arg2Of doses,of
R11540 T14760 T14759 arg1Of doses,high
R11541 T14760 T14761 arg1Of doses,of
R11542 T14763 T14764 arg1Of protein,and
R11543 T14764 T14761 arg2Of and,of
R11544 T14764 T14762 arg1Of and,OVA
R11545 T14765 T14764 arg2Of LPS,and
R11546 T14766 T14767 arg1Of We,showed
R11547 T14767 T14768 arg1Of showed,here
R11548 T14771 T14770 arg1Of induction,this
R11549 T14771 T14772 arg1Of induction,of
R11550 T14771 T14776 arg1Of induction,in vivo
R11551 T14771 T14777 arg1Of induction,was
R11552 T14771 T14784 arg2Of induction,reduced
R11553 T14775 T14772 arg2Of cells,of
R11554 T14775 T14773 arg1Of cells,IL-10
R11555 T14775 T14774 arg1Of cells,in Th1
R11556 T14778 T14780 arg1Of markedly,but
R11557 T14780 T14779 arg1Of but,","
R11558 T14780 T14781 arg1Of but,not
R11559 T14782 T14780 arg2Of totally,but
R11560 T14784 T14767 arg2Of reduced,showed
R11561 T14784 T14769 arg1Of reduced,that
R11562 T14784 T14777 arg2Of reduced,was
R11563 T14784 T14778 arg1Of reduced,markedly
R11564 T14784 T14782 arg1Of reduced,totally
R11565 T14784 T14783 arg1Of reduced,","
R11566 T14784 T14785 arg1Of reduced,in
R11567 T14784 T14794 arg1Of reduced,(
R11568 T14787 T14785 arg2Of T cells,in
R11569 T14787 T14786 arg1Of T cells,STAT4-deficient
R11570 T14788 T14784 arg3Of as,reduced
R11571 T14789 T14788 arg2Of observed,as
R11572 T14789 T14790 arg1Of observed,during
R11573 T14793 T14790 arg2Of infection,during
R11574 T14793 T14791 arg1Of infection,T.
R11575 T14793 T14792 arg1Of infection,gondii
R11576 T14796 T14794 arg2Of et al.,(
R11577 T14796 T14795 arg1Of et al.,Jankovic
R11578 T14796 T14797 arg1Of et al.,","
R11579 T14798 T14797 arg2Of 2002,","
R11580 T14799 T14794 arg3Of ),(
R11581 T14803 T14800 arg1Of activation,A
R11582 T14803 T14801 arg1Of activation,high
R11583 T14803 T14802 arg1Of activation,antigenic
R11584 T14803 T14804 arg1Of activation,during
R11585 T14803 T14825 arg1Of activation,may
R11586 T14803 T14826 arg1Of activation,compensate
R11587 T14807 T14805 arg1Of infection,T.
R11588 T14807 T14806 arg1Of infection,gondii
R11589 T14807 T14808 arg1Of infection,or
R11590 T14808 T14804 arg2Of or,during
R11591 T14808 T14812 arg2Of or,delivered
R11592 T14811 T14808 arg2Of doses,or
R11593 T14811 T14809 arg1Of doses,high
R11594 T14811 T14810 arg1Of doses,antigen
R11595 T14812 T14813 arg1Of delivered,in
R11596 T14812 T14818 arg1Of delivered,","
R11597 T14812 T14819 arg1Of delivered,as
R11598 T14815 T14813 arg2Of presence,in
R11599 T14815 T14814 arg1Of presence,the
R11600 T14815 T14816 arg1Of presence,of
R11601 T14817 T14816 arg2Of LPS,of
R11602 T14820 T14819 arg2Of seen,as
R11603 T14820 T14821 arg1Of seen,in
R11604 T14823 T14821 arg2Of system,in
R11605 T14823 T14822 arg1Of system,our
R11606 T14826 T14824 arg1Of compensate,","
R11607 T14826 T14825 arg2Of compensate,may
R11608 T14826 T14827 arg1Of compensate,for
R11609 T14830 T14827 arg2Of requirement,for
R11610 T14830 T14828 arg1Of requirement,an
R11611 T14830 T14829 arg1Of requirement,absolute
R11612 T14830 T14831 arg1Of requirement,for
R11613 T14832 T14831 arg2Of IL-12,for
R11614 T14832 T14833 arg1Of IL-12,in
R11615 T14835 T14833 arg2Of induction,in
R11616 T14835 T14834 arg1Of induction,the
R11617 T14835 T14836 arg1Of induction,of
R11618 T14835 T14838 arg1Of induction,by
R11619 T14837 T14836 arg2Of IL-10,of
R11620 T14840 T14838 arg2Of cells,by
R11621 T14840 T14839 arg1Of cells,Th1
R11622 T14844 T14841 arg2Of system,In
R11623 T14844 T14842 arg1Of system,our
R11624 T14844 T14843 arg1Of system,in vitro
R11625 T14847 T14846 arg2Of stimulation,repeated
R11626 T14847 T14848 arg1Of stimulation,of
R11627 T14847 T14851 arg1Of stimulation,with
R11628 T14847 T14855 arg1Of stimulation,allowed
R11629 T14850 T14848 arg2Of cells,of
R11630 T14850 T14849 arg1Of cells,Th1
R11631 T14854 T14851 arg2Of doses,with
R11632 T14854 T14852 arg1Of doses,high
R11633 T14854 T14853 arg1Of doses,antigen
R11634 T14855 T14841 arg1Of allowed,In
R11635 T14855 T14845 arg1Of allowed,","
R11636 T14857 T14855 arg2Of development,allowed
R11637 T14857 T14856 arg1Of development,the
R11638 T14857 T14858 arg1Of development,of
R11639 T14860 T14858 arg2Of cells,of
R11640 T14860 T14859 arg1Of cells,Th1
R11641 T14860 T14861 arg1Of cells,producing
R11642 T14861 T14863 arg1Of producing,in
R11643 T14862 T14861 arg2Of IL-10,producing
R11644 T14866 T14863 arg2Of manner,in
R11645 T14866 T14864 arg1Of manner,an
R11646 T14866 T14865 arg1Of manner,IL-12-dependent
R11647 T14868 T14867 arg1Of production,IL-10
R11648 T14868 T14869 arg1Of production,by
R11649 T14868 T14879 arg1Of production,was
R11650 T14868 T14880 arg1Of production,independent
R11651 T14871 T14869 arg2Of cells,by
R11652 T14871 T14870 arg1Of cells,Th1
R11653 T14871 T14872 arg2Of cells,induced
R11654 T14876 T14874 arg1Of dose,high
R11655 T14876 T14875 arg1Of dose,antigen
R11656 T14876 T14877 arg1Of dose,and
R11657 T14877 T14872 arg1Of and,induced
R11658 T14877 T14873 arg2Of and,by
R11659 T14878 T14877 arg2Of IL-12,and
R11660 T14879 T14883 arg1Of was,","
R11661 T14879 T14884 arg1Of was,in
R11662 T14880 T14879 arg2Of independent,was
R11663 T14880 T14881 arg1Of independent,of
R11664 T14882 T14881 arg2Of IFN-γ,of
R11665 T14885 T14884 arg2Of keeping,in
R11666 T14885 T14886 arg1Of keeping,with
R11667 T14888 T14886 arg2Of findings,with
R11668 T14888 T14887 arg1Of findings,previous
R11669 T14888 T14889 arg1Of findings,(
R11670 T14891 T14889 arg2Of et al.,(
R11671 T14891 T14890 arg1Of et al.,Jankovic
R11672 T14891 T14892 arg1Of et al.,","
R11673 T14893 T14892 arg2Of 2002,","
R11674 T14894 T14889 arg3Of ),(
R11675 T14898 T14897 arg1Of role,a
R11676 T14898 T14899 arg1Of role,for
R11677 T14898 T14901 arg1Of role,in
R11678 T14898 T14914 arg1Of role,has
R11679 T14898 T14915 arg1Of role,been
R11680 T14898 T14916 arg2Of role,suggested
R11681 T14900 T14899 arg2Of IFN-γ,for
R11682 T14902 T14901 arg2Of mediating,in
R11683 T14902 T14908 arg1Of mediating,during
R11684 T14904 T14902 arg2Of reactivation,mediating
R11685 T14904 T14903 arg1Of reactivation,IL-10
R11686 T14904 T14905 arg1Of reactivation,by
R11687 T14907 T14905 arg2Of cells,by
R11688 T14907 T14906 arg1Of cells,Th1
R11689 T14910 T14908 arg2Of infection,during
R11690 T14910 T14909 arg1Of infection,secondary
R11691 T14910 T14911 arg1Of infection,with
R11692 T14913 T14911 arg2Of gondii,with
R11693 T14913 T14912 arg1Of gondii,T.
R11694 T14916 T14895 arg1Of suggested,However
R11695 T14916 T14896 arg1Of suggested,","
R11696 T14916 T14914 arg2Of suggested,has
R11697 T14916 T14915 arg2Of suggested,been
R11698 T14916 T14917 arg1Of suggested,(
R11699 T14919 T14917 arg2Of et al.,(
R11700 T14919 T14918 arg1Of et al.,Shaw
R11701 T14919 T14920 arg1Of et al.,","
R11702 T14921 T14920 arg2Of 2006,","
R11703 T14922 T14917 arg3Of ),(
R11704 T14923 T14924 arg1Of We,have
R11705 T14923 T14925 arg1Of We,found
R11706 T14925 T14924 arg2Of found,have
R11707 T14928 T14927 arg1Of T cells,CD4+
R11708 T14928 T14929 arg2Of T cells,exposed
R11709 T14928 T14936 arg1Of T cells,do
R11710 T14928 T14938 arg1Of T cells,express
R11711 T14928 T14944 arg1Of T cells,can
R11712 T14928 T14945 arg1Of T cells,be
R11713 T14928 T14946 arg2Of T cells,induced
R11714 T14928 T14948 arg1Of T cells,produce
R11715 T14929 T14930 arg1Of exposed,to
R11716 T14933 T14930 arg2Of dose,to
R11717 T14933 T14931 arg1Of dose,a
R11718 T14933 T14932 arg1Of dose,high
R11719 T14933 T14934 arg1Of dose,of
R11720 T14935 T14934 arg2Of antigen,of
R11721 T14938 T14936 arg2Of express,do
R11722 T14938 T14937 arg1Of express,not
R11723 T14938 T14940 arg1Of express,upon
R11724 T14938 T14943 arg1Of express,but
R11725 T14939 T14938 arg2Of IL-10,express
R11726 T14941 T14940 arg2Of restimulation,upon
R11727 T14943 T14925 arg2Of but,found
R11728 T14943 T14926 arg1Of but,that
R11729 T14943 T14942 arg1Of but,","
R11730 T14946 T14943 arg2Of induced,but
R11731 T14946 T14944 arg2Of induced,can
R11732 T14946 T14945 arg2Of induced,be
R11733 T14948 T14946 arg3Of produce,induced
R11734 T14948 T14947 arg1Of produce,to
R11735 T14948 T14950 arg1Of produce,upon
R11736 T14948 T14952 arg1Of produce,to
R11737 T14948 T14958 arg1Of produce,in
R11738 T14948 T14962 arg1Of produce,in
R11739 T14949 T14948 arg2Of IL-10,produce
R11740 T14951 T14950 arg2Of re-exposure,upon
R11741 T14955 T14952 arg2Of dose,to
R11742 T14955 T14953 arg1Of dose,a
R11743 T14955 T14954 arg1Of dose,high
R11744 T14955 T14956 arg1Of dose,of
R11745 T14957 T14956 arg2Of antigen,of
R11746 T14961 T14958 arg2Of phase,in
R11747 T14961 T14959 arg1Of phase,the
R11748 T14961 T14960 arg1Of phase,recall
R11749 T14962 T14963 arg1Of in,the
R11750 T14962 T14965 arg1Of in,of
R11751 T14964 T14962 arg2Of absence,in
R11752 T14967 T14962 arg3Of IL-12,in
R11753 T14967 T14966 arg2Of IL-12,added
R11754 T14970 T14971 arg1Of this,is
R11755 T14970 T14972 arg1Of this,dependent
R11756 T14971 T14968 arg1Of is,However
R11757 T14971 T14969 arg1Of is,","
R11758 T14972 T14971 arg2Of dependent,is
R11759 T14972 T14973 arg1Of dependent,on
R11760 T14975 T14973 arg2Of induction,on
R11761 T14975 T14974 arg1Of induction,the
R11762 T14975 T14976 arg1Of induction,of
R11763 T14975 T14978 arg1Of induction,by
R11764 T14977 T14976 arg2Of IL-12,of
R11765 T14980 T14978 arg2Of DCs,by
R11766 T14980 T14979 arg1Of DCs,antigen-presenting
R11767 T14982 T14981 arg1Of combination,The
R11768 T14982 T14983 arg1Of combination,of
R11769 T14982 T14990 arg1Of combination,resulted
R11770 T14982 T14999 arg1Of combination,correlated
R11771 T14987 T14985 arg1Of dose,high
R11772 T14987 T14986 arg1Of dose,antigen
R11773 T14987 T14988 arg1Of dose,and
R11774 T14988 T14983 arg2Of and,of
R11775 T14988 T14984 arg1Of and,both
R11776 T14989 T14988 arg2Of IL-12,and
R11777 T14990 T14991 arg1Of resulted,in
R11778 T14990 T14998 arg1Of resulted,and
R11779 T14994 T14991 arg2Of levels,in
R11780 T14994 T14992 arg1Of levels,the
R11781 T14994 T14993 arg1Of levels,highest
R11782 T14994 T14995 arg1Of levels,of
R11783 T14997 T14995 arg2Of production,of
R11784 T14997 T14996 arg1Of production,IL-10
R11785 T14999 T14998 arg2Of correlated,and
R11786 T14999 T15000 arg1Of correlated,with
R11787 T15003 T15000 arg2Of levels,with
R11788 T15003 T15001 arg1Of levels,the
R11789 T15003 T15002 arg1Of levels,high
R11790 T15003 T15004 arg1Of levels,of
R11791 T15005 T15006 arg1Of ERK1,and
R11792 T15007 T15006 arg2Of ERK2,and
R11793 T15008 T15004 arg2Of activation,of
R11794 T15008 T15005 arg1Of activation,ERK1
R11795 T15008 T15007 arg1Of activation,ERK2
R11796 T15011 T15009 arg1Of expression,The
R11797 T15011 T15010 arg2Of expression,increased
R11798 T15011 T15012 arg1Of expression,of
R11799 T15011 T15019 arg1Of expression,will
R11800 T15011 T15020 arg1Of expression,induce
R11801 T15011 T15027 arg1Of expression,suggests
R11802 T15013 T15012 arg2Of IFN-γ,of
R11803 T15013 T15014 arg2Of IFN-γ,observed
R11804 T15014 T15015 arg1Of observed,during
R11805 T15018 T15015 arg2Of phase,during
R11806 T15018 T15016 arg1Of phase,the
R11807 T15018 T15017 arg1Of phase,secondary
R11808 T15020 T15019 arg2Of induce,will
R11809 T15020 T15026 arg1Of induce,and
R11810 T15023 T15020 arg2Of production,induce
R11811 T15023 T15021 arg2Of production,increased
R11812 T15023 T15022 arg1Of production,IL-12
R11813 T15023 T15024 arg1Of production,by
R11814 T15025 T15024 arg2Of DCs,by
R11815 T15027 T15026 arg2Of suggests,and
R11816 T15032 T15029 arg2Of activation,repeated
R11817 T15032 T15030 arg1Of activation,high-level
R11818 T15032 T15031 arg1Of activation,TCR
R11819 T15032 T15033 arg1Of activation,feeds
R11820 T15032 T15036 arg1Of activation,upregulate
R11821 T15033 T15027 arg2Of feeds,suggests
R11822 T15033 T15028 arg1Of feeds,that
R11823 T15033 T15034 arg1Of feeds,back
R11824 T15033 T15035 modOf feeds,to
R11825 T15036 T15035 arg1Of upregulate,to
R11826 T15038 T15036 arg2Of production,upregulate
R11827 T15038 T15037 arg1Of production,IL-12
R11828 T15038 T15039 arg1Of production,by
R11829 T15040 T15039 arg2Of DC,by
R11830 T15044 T15042 arg2Of likely,is
R11831 T15044 T15043 arg1Of likely,thus
R11832 T15049 T15046 arg2Of infection,in
R11833 T15049 T15047 arg1Of infection,T.
R11834 T15049 T15048 arg1Of infection,gondii
R11835 T15049 T15050 arg1Of infection,in vivo
R11836 T15049 T15051 arg1Of infection,(
R11837 T15053 T15051 arg2Of et al.,(
R11838 T15053 T15052 arg1Of et al.,Shaw
R11839 T15053 T15054 arg1Of et al.,","
R11840 T15055 T15054 arg2Of 2006,","
R11841 T15056 T15051 arg3Of ),(
R11842 T15059 T15058 arg1Of requirement,the
R11843 T15059 T15060 arg1Of requirement,for
R11844 T15059 T15066 arg1Of requirement,was
R11845 T15059 T15067 arg1Of requirement,for
R11846 T15061 T15060 arg2Of IFN-γ,for
R11847 T15061 T15063 arg1Of IFN-γ,induce
R11848 T15063 T15060 arg3Of induce,for
R11849 T15063 T15062 arg1Of induce,to
R11850 T15064 T15063 arg2Of IL-10,induce
R11851 T15066 T15041 arg1Of was,It
R11852 T15066 T15042 arg1Of was,is
R11853 T15066 T15044 arg1Of was,likely
R11854 T15066 T15045 arg1Of was,that
R11855 T15066 T15046 arg1Of was,in
R11856 T15066 T15057 arg1Of was,","
R11857 T15066 T15065 arg1Of was,","
R11858 T15067 T15066 arg2Of for,was
R11859 T15069 T15067 arg2Of upregulation,for
R11860 T15069 T15068 arg1Of upregulation,feedback
R11861 T15069 T15070 arg1Of upregulation,of
R11862 T15071 T15070 arg2Of IL-12,of
R11863 T15071 T15072 arg1Of IL-12,by
R11864 T15073 T15072 arg2Of DCs,by
R11865 T15073 T15074 arg1Of DCs,","
R11866 T15073 T15075 arg1Of DCs,which
R11867 T15073 T15078 arg1Of DCs,induced
R11868 T15077 T15076 arg2Of turn,in
R11869 T15078 T15076 arg1Of induced,in
R11870 T15078 T15080 arg1Of induced,in
R11871 T15079 T15078 arg2Of IL-10,induced
R11872 T15083 T15080 arg2Of cells,in
R11873 T15083 T15081 arg1Of cells,the
R11874 T15083 T15082 arg1Of cells,Th1
R11875 T15085 T15086 arg1Of IL-10,may
R11876 T15085 T15087 arg1Of IL-10,be
R11877 T15085 T15089 arg2Of IL-10,regulated
R11878 T15089 T15084 arg2Of regulated,Although
R11879 T15089 T15086 arg2Of regulated,may
R11880 T15089 T15087 arg2Of regulated,be
R11881 T15089 T15088 arg1Of regulated,differentially
R11882 T15089 T15090 arg1Of regulated,in
R11883 T15089 T15095 arg1Of regulated,as
R11884 T15089 T15099 arg1Of regulated,(
R11885 T15091 T15092 arg1Of Th1,and
R11886 T15093 T15092 arg2Of Th2,and
R11887 T15094 T15090 arg2Of cells,in
R11888 T15094 T15091 arg1Of cells,Th1
R11889 T15094 T15093 arg1Of cells,Th2
R11890 T15098 T15095 arg2Of reported,as
R11891 T15098 T15096 arg2Of reported,has
R11892 T15098 T15097 arg2Of reported,been
R11893 T15101 T15100 arg1Of et al.,Chang
R11894 T15101 T15102 arg1Of et al.,","
R11895 T15101 T15104 arg1Of et al.,;
R11896 T15103 T15102 arg2Of 2007,","
R11897 T15104 T15099 arg2Of ;,(
R11898 T15105 T15104 arg2Of Wang,;
R11899 T15105 T15106 arg1Of Wang,et al.
R11900 T15105 T15107 arg1Of Wang,","
R11901 T15108 T15107 arg2Of 2005,","
R11902 T15109 T15099 arg3Of ),(
R11903 T15112 T15111 arg1Of studies,some
R11904 T15112 T15113 arg1Of studies,suggest
R11905 T15113 T15120 arg1Of suggest,but
R11906 T15115 T15113 arg2Of existence,suggest
R11907 T15115 T15114 arg1Of existence,the
R11908 T15115 T15116 arg1Of existence,of
R11909 T15118 T15116 arg2Of pathways,of
R11910 T15118 T15117 arg1Of pathways,common
R11911 T15120 T15084 arg1Of but,Although
R11912 T15120 T15110 arg1Of but,","
R11913 T15120 T15119 arg1Of but,","
R11914 T15123 T15121 arg1Of basis,the
R11915 T15123 T15122 arg1Of basis,molecular
R11916 T15123 T15124 arg1Of basis,for
R11917 T15123 T15126 arg1Of basis,is
R11918 T15123 T15129 arg1Of basis,unclear
R11919 T15125 T15124 arg2Of these,for
R11920 T15126 T15120 arg2Of is,but
R11921 T15126 T15128 arg1Of is,yet
R11922 T15128 T15127 arg1Of yet,as
R11923 T15129 T15126 arg2Of unclear,is
R11924 T15132 T15130 arg1Of signals,Costimulatory
R11925 T15132 T15131 arg1Of signals,OX-40
R11926 T15132 T15133 arg1Of signals,have
R11927 T15132 T15134 arg1Of signals,been
R11928 T15132 T15135 arg2Of signals,shown
R11929 T15132 T15138 arg1Of signals,regulate
R11930 T15135 T15133 arg2Of shown,have
R11931 T15135 T15134 arg2Of shown,been
R11932 T15138 T15135 arg3Of regulate,shown
R11933 T15138 T15136 arg1Of regulate,to
R11934 T15138 T15137 arg1Of regulate,negatively
R11935 T15138 T15148 arg1Of regulate,in
R11936 T15138 T15153 arg1Of regulate,","
R11937 T15138 T15154 arg1Of regulate,whereas
R11938 T15140 T15138 arg2Of production,regulate
R11939 T15140 T15139 arg1Of production,IL-10
R11940 T15140 T15141 arg1Of production,(
R11941 T15143 T15141 arg2Of et al.,(
R11942 T15143 T15142 arg1Of et al.,Ito
R11943 T15143 T15144 arg1Of et al.,","
R11944 T15145 T15144 arg2Of 2005,","
R11945 T15146 T15141 arg3Of ),(
R11946 T15148 T15147 arg1Of in,both
R11947 T15149 T15150 arg1Of Th1,and
R11948 T15151 T15150 arg2Of Th2,and
R11949 T15152 T15148 arg2Of cells,in
R11950 T15152 T15149 arg1Of cells,Th1
R11951 T15152 T15151 arg1Of cells,Th2
R11952 T15156 T15155 arg1Of signaling,ICOS
R11953 T15156 T15157 arg1Of signaling,has
R11954 T15156 T15158 arg1Of signaling,been
R11955 T15156 T15159 arg2Of signaling,suggested
R11956 T15156 T15161 arg1Of signaling,induce
R11957 T15159 T15154 arg2Of suggested,whereas
R11958 T15159 T15157 arg2Of suggested,has
R11959 T15159 T15158 arg2Of suggested,been
R11960 T15161 T15159 arg3Of induce,suggested
R11961 T15161 T15160 arg1Of induce,to
R11962 T15161 T15174 arg1Of induce,in
R11963 T15162 T15161 arg2Of IL-10,induce
R11964 T15162 T15163 arg1Of IL-10,(
R11965 T15165 T15164 arg1Of et al.,Ito
R11966 T15165 T15166 arg1Of et al.,","
R11967 T15165 T15168 arg1Of et al.,;
R11968 T15167 T15166 arg2Of 2007,","
R11969 T15168 T15163 arg2Of ;,(
R11970 T15170 T15168 arg2Of et al.,;
R11971 T15170 T15169 arg1Of et al.,Witsch
R11972 T15170 T15171 arg1Of et al.,","
R11973 T15172 T15171 arg2Of 2002,","
R11974 T15173 T15163 arg3Of ),(
R11975 T15176 T15177 arg1Of Th1,and
R11976 T15177 T15175 arg1Of and,both
R11977 T15178 T15177 arg2Of Th2,and
R11978 T15179 T15174 arg2Of cells,in
R11979 T15179 T15176 arg1Of cells,Th1
R11980 T15179 T15178 arg1Of cells,Th2
R11981 T15184 T15182 arg2Of cases,in
R11982 T15184 T15183 arg1Of cases,some
R11983 T15187 T15186 arg1Of signaling,ICOS
R11984 T15187 T15189 arg1Of signaling,regulates
R11985 T15189 T15180 arg1Of regulates,However
R11986 T15189 T15181 arg1Of regulates,","
R11987 T15189 T15182 arg1Of regulates,in
R11988 T15189 T15185 arg1Of regulates,","
R11989 T15189 T15188 arg1Of regulates,also
R11990 T15191 T15192 arg1Of production,and
R11991 T15193 T15192 arg2Of Th2,and
R11992 T15194 T15189 arg2Of responses,regulates
R11993 T15194 T15190 arg1Of responses,IL-4
R11994 T15194 T15191 arg1Of responses,production
R11995 T15194 T15193 arg1Of responses,Th2
R11996 T15194 T15195 arg1Of responses,(
R11997 T15197 T15195 arg2Of et al.,(
R11998 T15197 T15196 arg1Of et al.,Greenwald
R11999 T15197 T15198 arg1Of et al.,","
R12000 T15199 T15198 arg2Of 2005,","
R12001 T15200 T15195 arg3Of ),(
R12002 T15201 T15203 arg1Of We,provide
R12003 T15203 T15202 arg1Of provide,now
R12004 T15203 T15226 arg1Of provide,","
R12005 T15203 T15227 arg1Of provide,although
R12006 T15206 T15203 arg2Of mechanism,provide
R12007 T15206 T15204 arg1Of mechanism,a
R12008 T15206 T15205 arg1Of mechanism,common
R12009 T15206 T15207 arg1Of mechanism,of
R12010 T15206 T15212 arg1Of mechanism,for
R12011 T15208 T15209 arg1Of ERK1,and
R12012 T15210 T15209 arg2Of ERK2,and
R12013 T15211 T15207 arg2Of activation,of
R12014 T15211 T15208 arg1Of activation,ERK1
R12015 T15211 T15210 arg1Of activation,ERK2
R12016 T15214 T15212 arg2Of regulation,for
R12017 T15214 T15213 arg1Of regulation,the
R12018 T15214 T15215 arg1Of regulation,of
R12019 T15217 T15215 arg2Of production,of
R12020 T15217 T15216 arg1Of production,IL-10
R12021 T15217 T15218 arg1Of production,in
R12022 T15219 T15220 arg1Of Th1,","
R12023 T15220 T15223 arg1Of ",",and
R12024 T15221 T15220 arg2Of Th2,","
R12025 T15223 T15222 arg1Of and,","
R12026 T15224 T15223 arg2Of Th17,and
R12027 T15225 T15218 arg2Of cells,in
R12028 T15225 T15219 arg1Of cells,Th1
R12029 T15225 T15221 arg1Of cells,Th2
R12030 T15225 T15224 arg1Of cells,Th17
R12031 T15229 T15228 arg1Of subset,each
R12032 T15229 T15230 arg1Of subset,differentiates
R12033 T15230 T15227 arg2Of differentiates,although
R12034 T15230 T15231 arg1Of differentiates,along
R12035 T15233 T15234 arg1Of distinct,and
R12036 T15235 T15234 arg2Of subset-specific,and
R12037 T15237 T15231 arg2Of pathway,along
R12038 T15237 T15232 arg1Of pathway,a
R12039 T15237 T15233 arg1Of pathway,distinct
R12040 T15237 T15235 arg1Of pathway,subset-specific
R12041 T15237 T15236 arg1Of pathway,transcriptional
R12042 T15238 T15239 arg1Of This,reinforces
R12043 T15241 T15239 arg2Of fact,reinforces
R12044 T15241 T15240 arg1Of fact,the
R12045 T15243 T15244 arg1Of IL-10,is
R12046 T15243 T15253 arg1Of IL-10,is
R12047 T15243 T15254 arg2Of IL-10,produced
R12048 T15244 T15245 arg1Of is,not
R12049 T15244 T15251 arg1Of is,but
R12050 T15249 T15244 arg2Of cytokine,is
R12051 T15249 T15246 arg1Of cytokine,a
R12052 T15249 T15247 arg1Of cytokine,Th
R12053 T15249 T15248 arg1Of cytokine,cell-subset-specific
R12054 T15251 T15241 arg2Of but,fact
R12055 T15251 T15242 arg1Of but,that
R12056 T15251 T15250 arg1Of but,","
R12057 T15254 T15251 arg2Of produced,but
R12058 T15254 T15252 arg1Of produced,instead
R12059 T15254 T15253 arg2Of produced,is
R12060 T15254 T15255 arg1Of produced,in
R12061 T15254 T15260 arg1Of produced,during
R12062 T15258 T15257 arg1Of regulated,tightly
R12063 T15259 T15255 arg2Of fashion,in
R12064 T15259 T15256 arg1Of fashion,a
R12065 T15259 T15258 arg1Of fashion,regulated
R12066 T15263 T15260 arg2Of pathway,during
R12067 T15263 T15261 arg1Of pathway,each
R12068 T15263 T15262 arg1Of pathway,differentiation
R12069 T15265 T15264 arg2Of note,Of
R12070 T15268 T15267 arg1Of role,a
R12071 T15268 T15269 arg1Of role,for
R12072 T15268 T15274 arg1Of role,in
R12073 T15268 T15280 arg1Of role,has
R12074 T15268 T15282 arg1Of role,been
R12075 T15268 T15283 arg2Of role,described
R12076 T15270 T15271 arg1Of ERK1,and
R12077 T15272 T15271 arg2Of ERK2,and
R12078 T15273 T15269 arg2Of activation,for
R12079 T15273 T15270 arg1Of activation,ERK1
R12080 T15273 T15272 arg1Of activation,ERK2
R12081 T15276 T15274 arg2Of induction,in
R12082 T15276 T15275 arg1Of induction,the
R12083 T15276 T15277 arg1Of induction,of
R12084 T15279 T15277 arg2Of production,of
R12085 T15279 T15278 arg1Of production,IL-10
R12086 T15283 T15264 arg1Of described,Of
R12087 T15283 T15266 arg1Of described,","
R12088 T15283 T15280 arg2Of described,has
R12089 T15283 T15281 arg1Of described,already
R12090 T15283 T15282 arg2Of described,been
R12091 T15283 T15284 arg1Of described,for
R12092 T15285 T15286 arg1Of macrophages,and
R12093 T15286 T15284 arg2Of and,for
R12094 T15286 T15288 arg1Of and,(
R12095 T15287 T15286 arg2Of DC,and
R12096 T15290 T15289 arg1Of et al.,Agrawal
R12097 T15290 T15291 arg1Of et al.,","
R12098 T15290 T15293 arg1Of et al.,;
R12099 T15292 T15291 arg2Of 2006,","
R12100 T15293 T15288 arg2Of ;,(
R12101 T15294 T15293 arg2Of Hacker,;
R12102 T15294 T15295 arg1Of Hacker,et al.
R12103 T15294 T15296 arg1Of Hacker,","
R12104 T15297 T15296 arg2Of 1999,","
R12105 T15298 T15288 arg3Of ),(
R12106 T15301 T15299 arg1Of regulation,Differential
R12107 T15301 T15300 arg1Of regulation,transcriptional
R12108 T15301 T15302 arg1Of regulation,of
R12109 T15301 T15304 arg1Of regulation,in
R12110 T15301 T15309 arg1Of regulation,has
R12111 T15301 T15310 arg1Of regulation,been
R12112 T15301 T15311 arg2Of regulation,suggested
R12113 T15303 T15302 arg2Of IL-10,of
R12114 T15305 T15306 arg1Of Th1,and
R12115 T15307 T15306 arg2Of Th2,and
R12116 T15308 T15304 arg2Of cells,in
R12117 T15308 T15305 arg1Of cells,Th1
R12118 T15308 T15307 arg1Of cells,Th2
R12119 T15311 T15309 arg2Of suggested,has
R12120 T15311 T15310 arg2Of suggested,been
R12121 T15311 T15312 arg1Of suggested,(
R12122 T15311 T15324 arg1Of suggested,and
R12123 T15314 T15313 arg1Of et al.,Chang
R12124 T15314 T15315 arg1Of et al.,","
R12125 T15314 T15317 arg1Of et al.,;
R12126 T15316 T15315 arg2Of 2007,","
R12127 T15317 T15312 arg2Of ;,(
R12128 T15318 T15317 arg2Of Wang,;
R12129 T15318 T15319 arg1Of Wang,et al.
R12130 T15318 T15320 arg1Of Wang,","
R12131 T15321 T15320 arg2Of 2005,","
R12132 T15322 T15312 arg3Of ),(
R12133 T15324 T15323 arg1Of and,","
R12134 T15327 T15325 arg1Of acetylation,extensive
R12135 T15327 T15326 arg1Of acetylation,histone
R12136 T15327 T15328 arg1Of acetylation,of
R12137 T15327 T15332 arg1Of acetylation,is
R12138 T15327 T15333 arg1Of acetylation,detectable
R12139 T15331 T15328 arg2Of gene,of
R12140 T15331 T15329 arg1Of gene,the
R12141 T15331 T15330 arg1Of gene,IL-10
R12142 T15332 T15324 arg2Of is,and
R12143 T15333 T15332 arg2Of detectable,is
R12144 T15333 T15334 arg1Of detectable,in
R12145 T15336 T15335 arg1Of polarized,fully
R12146 T15338 T15336 arg1Of cells,polarized
R12147 T15338 T15337 arg1Of cells,Th2
R12148 T15338 T15340 arg1Of cells,but
R12149 T15340 T15334 arg2Of but,in
R12150 T15340 T15339 arg1Of but,","
R12151 T15340 T15341 arg1Of but,not
R12152 T15343 T15340 arg2Of cells,but
R12153 T15343 T15342 arg1Of cells,Th1
R12154 T15343 T15344 arg1Of cells,(
R12155 T15346 T15344 arg2Of et al.,(
R12156 T15346 T15345 arg1Of et al.,Chang
R12157 T15346 T15347 arg1Of et al.,","
R12158 T15348 T15347 arg2Of 2007,","
R12159 T15349 T15344 arg3Of ),(
R12160 T15350 T15351 arg1Of We,provide
R12161 T15352 T15351 arg2Of evidence,provide
R12162 T15354 T15355 arg1Of IL-10,is
R12163 T15354 T15356 arg2Of IL-10,produced
R12164 T15356 T15353 arg1Of produced,that
R12165 T15356 T15355 arg2Of produced,is
R12166 T15356 T15357 arg1Of produced,in
R12167 T15356 T15361 arg1Of produced,and
R12168 T15360 T15357 arg2Of cells,in
R12169 T15360 T15358 arg1Of cells,canonical
R12170 T15360 T15359 arg1Of cells,Th1
R12171 T15361 T15352 arg2Of and,evidence
R12172 T15362 T15361 arg2Of that,and
R12173 T15364 T15363 arg1Of expression,its
R12174 T15364 T15365 arg1Of expression,correlates
R12175 T15365 T15362 arg2Of correlates,that
R12176 T15365 T15366 arg1Of correlates,with
R12177 T15365 T15376 arg1Of correlates,","
R12178 T15365 T15377 arg1Of correlates,in
R12179 T15368 T15367 arg1Of expression,the
R12180 T15368 T15369 arg1Of expression,of
R12181 T15368 T15371 arg1Of expression,and
R12182 T15370 T15369 arg2Of T-bet,of
R12183 T15371 T15366 arg2Of and,with
R12184 T15375 T15371 arg2Of production,and
R12185 T15375 T15372 arg1Of production,the
R12186 T15375 T15373 arg1Of production,highest
R12187 T15375 T15374 arg1Of production,IFN-γ
R12188 T15378 T15377 arg2Of keeping,in
R12189 T15378 T15379 arg1Of keeping,with
R12190 T15381 T15379 arg2Of observations,with
R12191 T15381 T15380 arg1Of observations,our
R12192 T15385 T15383 arg1Of stimulation,high-dose
R12193 T15385 T15384 arg1Of stimulation,antigen
R12194 T15385 T15386 arg1Of stimulation,and
R12195 T15386 T15389 arg1Of and,are
R12196 T15386 T15390 arg2Of and,required
R12197 T15388 T15386 arg2Of signaling,and
R12198 T15388 T15387 arg1Of signaling,IL-12
R12199 T15390 T15381 arg2Of required,observations
R12200 T15390 T15382 arg1Of required,that
R12201 T15390 T15389 arg2Of required,are
R12202 T15390 T15391 arg1Of required,for
R12203 T15392 T15393 arg1Of IL-10,and
R12204 T15394 T15393 arg2Of IFN-γ,and
R12205 T15395 T15391 arg2Of expression,for
R12206 T15395 T15392 arg1Of expression,IL-10
R12207 T15395 T15394 arg1Of expression,IFN-γ
R12208 T15396 T15397 arg1Of It,has
R12209 T15396 T15399 arg1Of It,been
R12210 T15396 T15400 arg2Of It,shown
R12211 T15400 T15397 arg2Of shown,has
R12212 T15400 T15398 arg1Of shown,also
R12213 T15400 T15399 arg2Of shown,been
R12214 T15402 T15403 arg1Of maintenance,of
R12215 T15402 T15406 arg1Of maintenance,is
R12216 T15402 T15407 arg1Of maintenance,conditional
R12217 T15405 T15403 arg2Of expression,of
R12218 T15405 T15404 arg1Of expression,IL-10
R12219 T15406 T15400 arg3Of is,shown
R12220 T15406 T15401 arg1Of is,that
R12221 T15406 T15412 arg1Of is,unless
R12222 T15407 T15406 arg2Of conditional,is
R12223 T15407 T15408 arg1Of conditional,on
R12224 T15409 T15410 arg1Of IL-12,or
R12225 T15410 T15408 arg2Of or,on
R12226 T15411 T15410 arg2Of IL-4,or
R12227 T15415 T15413 arg1Of gene,the
R12228 T15415 T15414 arg1Of gene,IL-10
R12229 T15415 T15416 arg1Of gene,is
R12230 T15415 T15417 arg2Of gene,imprinted
R12231 T15417 T15412 arg2Of imprinted,unless
R12232 T15417 T15416 arg2Of imprinted,is
R12233 T15419 T15417 arg1Of GATA-3,imprinted
R12234 T15419 T15418 arg2Of GATA-3,by
R12235 T15419 T15420 arg1Of GATA-3,(
R12236 T15419 T15426 arg1Of GATA-3,","
R12237 T15419 T15427 arg1Of GATA-3,which
R12238 T15419 T15428 arg1Of GATA-3,can
R12239 T15419 T15429 arg1Of GATA-3,remodel
R12240 T15422 T15420 arg2Of et al.,(
R12241 T15422 T15421 arg1Of et al.,Chang
R12242 T15422 T15423 arg1Of et al.,","
R12243 T15424 T15423 arg2Of 2007,","
R12244 T15425 T15420 arg3Of ),(
R12245 T15429 T15428 arg2Of remodel,can
R12246 T15429 T15433 arg1Of remodel,","
R12247 T15429 T15435 modOf remodel,explaining
R12248 T15432 T15429 arg2Of locus,remodel
R12249 T15432 T15430 arg1Of locus,the
R12250 T15432 T15431 arg1Of locus,IL-10
R12251 T15435 T15434 arg1Of explaining,thus
R12252 T15438 T15435 arg2Of amounts,explaining
R12253 T15438 T15436 arg1Of amounts,the
R12254 T15438 T15437 arg1Of amounts,highest
R12255 T15438 T15439 arg1Of amounts,of
R12256 T15438 T15441 arg2Of amounts,produced
R12257 T15440 T15439 arg2Of IL-10,of
R12258 T15444 T15441 arg1Of cells,produced
R12259 T15444 T15442 arg2Of cells,by
R12260 T15444 T15443 arg1Of cells,Th2
R12261 T15444 T15445 arg1Of cells,(
R12262 T15447 T15446 arg1Of et al.,Chang
R12263 T15447 T15448 arg1Of et al.,","
R12264 T15447 T15450 arg1Of et al.,;
R12265 T15449 T15448 arg2Of 2007,","
R12266 T15450 T15445 arg2Of ;,(
R12267 T15451 T15450 arg2Of Shoemaker,;
R12268 T15451 T15452 arg1Of Shoemaker,et al.
R12269 T15451 T15453 arg1Of Shoemaker,","
R12270 T15454 T15453 arg2Of 2006,","
R12271 T15455 T15445 arg3Of ),(
R12272 T15456 T15457 arg1Of We,show
R12273 T15457 T15458 arg1Of show,here
R12274 T15462 T15463 arg1Of dose,and
R12275 T15463 T15460 arg1Of and,high
R12276 T15463 T15461 arg1Of and,antigen
R12277 T15463 T15466 arg1Of and,downregulate
R12278 T15464 T15463 arg2Of IL-12,and
R12279 T15466 T15457 arg2Of downregulate,show
R12280 T15466 T15459 arg1Of downregulate,that
R12281 T15466 T15465 arg1Of downregulate,drastically
R12282 T15466 T15469 arg1Of downregulate,","
R12283 T15466 T15470 modOf downregulate,suggesting
R12284 T15468 T15466 arg2Of expression,downregulate
R12285 T15468 T15467 arg1Of expression,Gata-3
R12286 T15473 T15472 arg1Of factors,additional
R12287 T15473 T15474 arg1Of factors,are
R12288 T15473 T15475 arg1Of factors,in
R12289 T15474 T15470 arg2Of are,suggesting
R12290 T15474 T15471 arg1Of are,that
R12291 T15474 T15484 arg1Of are,","
R12292 T15474 T15486 arg1Of are,transiently
R12293 T15475 T15474 arg2Of in,are
R12294 T15476 T15475 arg2Of place,in
R12295 T15476 T15477 modOf place,to
R12296 T15478 T15477 arg1Of induce,to
R12297 T15480 T15478 arg2Of expression,induce
R12298 T15480 T15479 arg1Of expression,IL-10
R12299 T15480 T15481 arg1Of expression,in
R12300 T15483 T15481 arg2Of cells,in
R12301 T15483 T15482 arg1Of cells,Th1
R12302 T15486 T15485 arg1Of transiently,albeit
R12303 T15487 T15488 arg1Of Expression,of
R12304 T15487 T15490 arg1Of Expression,was
R12305 T15487 T15492 arg2Of Expression,diminished
R12306 T15487 T15501 arg1Of Expression,was
R12307 T15487 T15503 arg2Of Expression,maintained
R12308 T15487 T15507 arg1Of Expression,present
R12309 T15489 T15488 arg2Of c-maf,of
R12310 T15492 T15490 arg2Of diminished,was
R12311 T15492 T15491 arg1Of diminished,greatly
R12312 T15492 T15499 arg1Of diminished,and
R12313 T15496 T15492 arg1Of doses,diminished
R12314 T15496 T15493 arg2Of doses,by
R12315 T15496 T15494 arg1Of doses,high
R12316 T15496 T15495 arg1Of doses,antigen
R12317 T15496 T15497 arg1Of doses,in
R12318 T15498 T15497 arg2Of T cells,in
R12319 T15503 T15506 arg1Of maintained,and
R12320 T15505 T15503 arg1Of IL-12,maintained
R12321 T15505 T15504 arg2Of IL-12,by
R12322 T15506 T15499 arg2Of and,and
R12323 T15506 T15500 arg1Of and,yet
R12324 T15506 T15501 arg2Of and,was
R12325 T15506 T15502 arg1Of and,unexpectedly
R12326 T15507 T15506 arg2Of present,and
R12327 T15507 T15508 arg1Of present,in
R12328 T15510 T15508 arg2Of cells,in
R12329 T15510 T15509 arg1Of cells,Th17
R12330 T15513 T15512 arg1Of expression,c-maf
R12331 T15513 T15514 arg1Of expression,is
R12332 T15513 T15515 arg1Of expression,common
R12333 T15513 T15530 arg1Of expression,is
R12334 T15513 T15531 arg1Of expression,dependent
R12335 T15514 T15525 arg1Of is,and
R12336 T15514 T15526 arg1Of is,","
R12337 T15515 T15514 arg2Of common,is
R12338 T15515 T15516 arg1Of common,to
R12339 T15518 T15519 arg1Of Th1,","
R12340 T15519 T15522 arg1Of ",",and
R12341 T15520 T15519 arg2Of Th2,","
R12342 T15522 T15521 arg1Of and,","
R12343 T15523 T15522 arg2Of Th17,and
R12344 T15524 T15516 arg2Of cells,to
R12345 T15524 T15517 arg1Of cells,IL-10-producing
R12346 T15524 T15518 arg1Of cells,Th1
R12347 T15524 T15520 arg1Of cells,Th2
R12348 T15524 T15523 arg1Of cells,Th17
R12349 T15526 T15511 arg1Of ",",That
R12350 T15526 T15543 arg1Of ",",is
R12351 T15526 T15544 arg1Of ",",of
R12352 T15528 T15527 arg2Of IL-10,like
R12353 T15530 T15526 arg2Of is,","
R12354 T15530 T15527 arg1Of is,like
R12355 T15530 T15529 arg1Of is,","
R12356 T15531 T15530 arg2Of dependent,is
R12357 T15531 T15532 arg1Of dependent,on
R12358 T15534 T15532 arg2Of activation,on
R12359 T15534 T15533 arg1Of activation,ERK
R12360 T15534 T15535 arg1Of activation,in
R12361 T15534 T15540 arg1Of activation,for
R12362 T15536 T15537 arg1Of Th1,and
R12363 T15538 T15537 arg2Of Th17,and
R12364 T15539 T15535 arg2Of cells,in
R12365 T15539 T15536 arg1Of cells,Th1
R12366 T15539 T15538 arg1Of cells,Th17
R12367 T15542 T15540 arg2Of expression,for
R12368 T15542 T15541 arg1Of expression,its
R12369 T15543 T15546 arg1Of is,because
R12370 T15544 T15543 arg2Of of,is
R12371 T15545 T15544 arg2Of interest,of
R12372 T15547 T15548 arg1Of c-Maf,has
R12373 T15547 T15549 arg1Of c-Maf,been
R12374 T15547 T15550 arg2Of c-Maf,shown
R12375 T15547 T15552 arg1Of c-Maf,be
R12376 T15550 T15546 arg2Of shown,because
R12377 T15550 T15548 arg2Of shown,has
R12378 T15550 T15549 arg2Of shown,been
R12379 T15552 T15550 arg3Of be,shown
R12380 T15552 T15551 arg1Of be,to
R12381 T15556 T15552 arg2Of factor,be
R12382 T15556 T15553 arg1Of factor,an
R12383 T15556 T15554 arg1Of factor,essential
R12384 T15556 T15555 arg1Of factor,transcription
R12385 T15556 T15557 arg1Of factor,for
R12386 T15559 T15557 arg2Of expression,for
R12387 T15559 T15558 arg1Of expression,IL-10
R12388 T15559 T15560 arg1Of expression,in
R12389 T15561 T15560 arg2Of macrophages,in
R12390 T15561 T15562 arg1Of macrophages,(
R12391 T15564 T15562 arg2Of et al.,(
R12392 T15564 T15563 arg1Of et al.,Cao
R12393 T15564 T15565 arg1Of et al.,","
R12394 T15566 T15565 arg2Of 2005,","
R12395 T15567 T15562 arg3Of ),(
R12396 T15569 T15568 arg2Of summary,In
R12397 T15571 T15572 arg1Of we,show
R12398 T15572 T15568 arg1Of show,In
R12399 T15572 T15570 arg1Of show,","
R12400 T15575 T15576 arg1Of Th1,","
R12401 T15576 T15579 arg1Of ",",and
R12402 T15577 T15576 arg2Of Th2,","
R12403 T15579 T15578 arg1Of and,","
R12404 T15580 T15579 arg2Of Th17,and
R12405 T15583 T15575 arg1Of subsets,Th1
R12406 T15583 T15577 arg1Of subsets,Th2
R12407 T15583 T15580 arg1Of subsets,Th17
R12408 T15583 T15581 arg1Of subsets,CD4+
R12409 T15583 T15582 arg1Of subsets,T cell
R12410 T15583 T15584 arg1Of subsets,differentiate
R12411 T15584 T15574 arg2Of differentiate,although
R12412 T15584 T15585 arg1Of differentiate,along
R12413 T15587 T15586 arg1Of signaling,distinct
R12414 T15587 T15588 arg1Of signaling,and
R12415 T15588 T15585 arg2Of and,along
R12416 T15590 T15588 arg2Of pathways,and
R12417 T15590 T15589 arg1Of pathways,transcriptional
R12418 T15592 T15593 arg1Of they,can
R12419 T15592 T15595 arg1Of they,be
R12420 T15592 T15596 arg2Of they,induced
R12421 T15596 T15572 arg2Of induced,show
R12422 T15596 T15573 arg1Of induced,that
R12423 T15596 T15574 arg1Of induced,although
R12424 T15596 T15591 arg1Of induced,","
R12425 T15596 T15593 arg2Of induced,can
R12426 T15596 T15594 arg1Of induced,all
R12427 T15596 T15595 arg2Of induced,be
R12428 T15596 T15597 modOf induced,to
R12429 T15598 T15597 arg1Of make,to
R12430 T15599 T15598 arg2Of IL-10,make
R12431 T15600 T15601 arg1Of ERK1,and
R12432 T15601 T15604 arg1Of and,is
R12433 T15601 T15605 arg2Of and,required
R12434 T15603 T15601 arg2Of activation,and
R12435 T15603 T15602 arg1Of activation,ERK2
R12436 T15605 T15604 arg2Of required,is
R12437 T15605 T15606 arg1Of required,for
R12438 T15605 T15609 arg1Of required,by
R12439 T15608 T15606 arg2Of production,for
R12440 T15608 T15607 arg1Of production,IL-10
R12441 T15614 T15609 arg2Of subsets,by
R12442 T15614 T15610 arg1Of subsets,all
R12443 T15614 T15611 arg1Of subsets,these
R12444 T15614 T15612 arg1Of subsets,Th
R12445 T15614 T15613 arg1Of subsets,cell
R12446 T15615 T15617 arg1Of With,to
R12447 T15616 T15615 arg2Of regard,With
R12448 T15619 T15615 arg3Of expression,With
R12449 T15619 T15618 arg1Of expression,the
R12450 T15619 T15620 arg1Of expression,of
R12451 T15619 T15622 arg1Of expression,by
R12452 T15621 T15620 arg2Of IL-10,of
R12453 T15624 T15622 arg2Of cells,by
R12454 T15624 T15623 arg1Of cells,Th1
R12455 T15627 T15626 arg1Of data,our
R12456 T15627 T15628 arg1Of data,provide
R12457 T15628 T15615 arg1Of provide,With
R12458 T15628 T15625 arg1Of provide,","
R12459 T15630 T15628 arg2Of mechanism,provide
R12460 T15630 T15629 arg1Of mechanism,a
R12461 T15630 T15631 arg1Of mechanism,for
R12462 T15632 T15631 arg2Of how,for
R12463 T15634 T15633 arg1Of expression,IL-10
R12464 T15634 T15635 arg1Of expression,is
R12465 T15634 T15636 arg2Of expression,induced
R12466 T15634 T15639 arg2Of expression,amplified
R12467 T15634 T15641 arg2Of expression,regulated
R12468 T15636 T15637 arg1Of induced,and
R12469 T15637 T15632 arg1Of and,how
R12470 T15637 T15635 arg2Of and,is
R12471 T15639 T15640 arg1Of amplified,and
R12472 T15640 T15637 arg2Of and,and
R12473 T15640 T15638 arg1Of and,then
R12474 T15641 T15640 arg2Of regulated,and
R12475 T15644 T15639 arg1Of levels,amplified
R12476 T15644 T15641 arg1Of levels,regulated
R12477 T15644 T15642 arg2Of levels,by
R12478 T15644 T15643 arg1Of levels,the
R12479 T15644 T15645 arg1Of levels,of
R12480 T15646 T15647 arg1Of antigen,and
R12481 T15647 T15645 arg2Of and,of
R12482 T15647 T15649 arg2Of and,encountered
R12483 T15648 T15647 arg2Of IL-12,and
R12484 T15649 T15650 arg1Of encountered,in
R12485 T15652 T15650 arg2Of environment,in
R12486 T15652 T15651 arg1Of environment,the
R12487 T15653 T15654 arg1Of This,provides
R12488 T15656 T15654 arg2Of mechanism,provides
R12489 T15656 T15655 arg1Of mechanism,a
R12490 T15656 T15657 arg1Of mechanism,whereby
R12491 T15660 T15658 arg1Of cell,a
R12492 T15660 T15659 arg1Of cell,Th1
R12493 T15660 T15661 arg1Of cell,responds
R12494 T15660 T15699 arg1Of cell,prevent
R12495 T15661 T15662 arg1Of responds,to
R12496 T15661 T15665 arg1Of responds,","
R12497 T15661 T15666 modOf responds,reflecting
R12498 T15661 T15672 arg1Of responds,","
R12499 T15661 T15673 modOf responds,to
R12500 T15661 T15682 modOf responds,to
R12501 T15661 T15697 arg1Of responds,and
R12502 T15664 T15662 arg2Of signals,to
R12503 T15664 T15663 arg1Of signals,extrinsic
R12504 T15668 T15666 arg2Of inflammation,reflecting
R12505 T15668 T15667 arg2Of inflammation,increased
R12506 T15668 T15669 arg1Of inflammation,in
R12507 T15671 T15669 arg2Of tissue,in
R12508 T15671 T15670 arg1Of tissue,the
R12509 T15675 T15673 arg1Of regulate,to
R12510 T15675 T15674 arg1Of regulate,tightly
R12511 T15675 T15680 arg1Of regulate,so
R12512 T15675 T15681 arg1Of regulate,as
R12513 T15677 T15675 arg2Of production,regulate
R12514 T15677 T15676 arg1Of production,the
R12515 T15677 T15678 arg1Of production,of
R12516 T15679 T15678 arg2Of IL-10,of
R12517 T15683 T15681 arg2Of allow,as
R12518 T15683 T15682 arg1Of allow,to
R12519 T15686 T15683 arg2Of response,allow
R12520 T15686 T15684 arg1Of response,a
R12521 T15686 T15685 arg1Of response,protective
R12522 T15686 T15688 arg1Of response,eradicate
R12523 T15688 T15683 arg3Of eradicate,allow
R12524 T15688 T15687 arg1Of eradicate,to
R12525 T15690 T15688 arg2Of pathogen,eradicate
R12526 T15690 T15689 arg1Of pathogen,a
R12527 T15690 T15691 arg1Of pathogen,with
R12528 T15693 T15691 arg2Of damage,with
R12529 T15693 T15692 arg1Of damage,minimal
R12530 T15693 T15694 arg1Of damage,to
R12531 T15696 T15694 arg2Of host,to
R12532 T15696 T15695 arg1Of host,the
R12533 T15697 T15657 arg2Of and,whereby
R12534 T15699 T15697 arg2Of prevent,and
R12535 T15699 T15698 arg1Of prevent,also
R12536 T15701 T15699 arg2Of infection,prevent
R12537 T15701 T15700 arg1Of infection,chronic
R12538 T15705 T15704 arg1Of findings,our
R12539 T15705 T15706 arg1Of findings,have
R12540 T15705 T15723 arg1Of findings,may
R12541 T15705 T15724 arg1Of findings,be
R12542 T15705 T15725 arg1Of findings,of
R12543 T15706 T15715 arg1Of have,during
R12544 T15706 T15722 arg1Of have,and
R12545 T15708 T15706 arg2Of implications,have
R12546 T15708 T15707 arg1Of implications,important
R12547 T15708 T15709 arg1Of implications,for
R12548 T15711 T15709 arg2Of regulation,for
R12549 T15711 T15710 arg1Of regulation,the
R12550 T15711 T15712 arg1Of regulation,of
R12551 T15714 T15712 arg2Of production,of
R12552 T15714 T15713 arg1Of production,IL-10
R12553 T15719 T15715 arg2Of response,during
R12554 T15719 T15716 arg1Of response,an
R12555 T15719 T15717 arg1Of response,inflammatory
R12556 T15719 T15718 arg1Of response,Th1
R12557 T15719 T15720 arg1Of response,in
R12558 T15721 T15720 arg2Of infection,in
R12559 T15722 T15702 arg1Of and,Moreover
R12560 T15722 T15703 arg1Of and,","
R12561 T15724 T15722 arg2Of be,and
R12562 T15724 T15723 arg2Of be,may
R12563 T15725 T15724 arg2Of of,be
R12564 T15726 T15725 arg2Of relevance,of
R12565 T15726 T15727 arg1Of relevance,for
R12566 T15726 T15733 arg1Of relevance,for
R12567 T15727 T15732 arg1Of for,and
R12568 T15729 T15727 arg2Of design,for
R12569 T15729 T15728 arg1Of design,the
R12570 T15729 T15730 arg1Of design,of
R12571 T15731 T15730 arg2Of vaccines,of
R12572 T15733 T15732 arg2Of for,and
R12573 T15734 T15733 arg2Of strategies,for
R12574 T15734 T15735 arg1Of strategies,in
R12575 T15736 T15735 arg2Of immunotherapy,in
R12576 T15736 T15737 arg1Of immunotherapy,in
R12577 T15739 T15737 arg2Of diseases,in
R12578 T15739 T15738 arg1Of diseases,infectious
R15108 T19140 T19141 arg1Of Isolation,of
R15109 T19140 T19146 arg1Of Isolation,of
R15110 T19140 T19152 arg1Of Isolation,for
R15111 T19141 T19145 arg1Of of,and
R15112 T19144 T19141 arg2Of Cells,of
R15113 T19144 T19142 arg1Of Cells,CD4+
R15114 T19144 T19143 arg1Of Cells,T
R15115 T19146 T19145 arg2Of of,and
R15116 T19148 T19147 arg1Of DC,Splenic
R15117 T19148 T19149 arg1Of DC,and
R15118 T19149 T19146 arg2Of and,of
R15119 T19151 T19149 arg2Of Culture,and
R15120 T19151 T19150 arg1Of Culture,Cell
R15121 T19156 T19152 arg2Of Differentiation,for
R15122 T19156 T19153 arg1Of Differentiation,T
R15123 T19156 T19154 arg1Of Differentiation,Cell
R15124 T19156 T19155 arg1Of Differentiation,Phenotype
R15125 T19158 T19157 arg1Of cells,T
R15126 T19158 T19159 arg1Of cells,were
R15127 T19158 T19160 arg2Of cells,sorted
R15128 T19160 T19159 arg2Of sorted,were
R15129 T19160 T19161 arg1Of sorted,for
R15130 T19160 T19172 arg1Of sorted,on
R15131 T19162 T19163 arg1Of CD4+CD62Lhi,","
R15132 T19163 T19166 arg1Of ",",or
R15133 T19164 T19163 arg2Of CD4+CD62LhiCD25−,","
R15134 T19166 T19161 arg2Of or,for
R15135 T19166 T19165 arg1Of or,","
R15136 T19166 T19168 arg1Of or,to
R15137 T19167 T19166 arg2Of CD4+CD44loCD25−,or
R15138 T19170 T19169 arg1Of 98,>
R15139 T19171 T19168 arg2Of %,to
R15140 T19171 T19170 arg1Of %,98
R15141 T19175 T19172 arg2Of cytometer,on
R15142 T19175 T19173 arg1Of cytometer,a
R15143 T19175 T19174 arg1Of cytometer,Moflo
R15144 T19175 T19176 arg1Of cytometer,(
R15145 T19175 T19179 arg1Of cytometer,as
R15146 T19177 T19176 arg2Of Cytomation,(
R15147 T19178 T19176 arg3Of ),(
R15148 T19179 T19180 arg1Of as,before
R15149 T19179 T19181 arg1Of as,(
R15150 T19183 T19182 arg1Of et al.,Shoemaker
R15151 T19183 T19184 arg1Of et al.,","
R15152 T19183 T19186 arg1Of et al.,;
R15153 T19185 T19184 arg2Of 2006,","
R15154 T19186 T19181 arg2Of ;,(
R15155 T19187 T19186 arg2Of Veldhoen,;
R15156 T19187 T19188 arg1Of Veldhoen,et al.
R15157 T19187 T19189 arg1Of Veldhoen,","
R15158 T19190 T19189 arg2Of 2009,","
R15159 T19191 T19181 arg3Of ),(
R15160 T19194 T19192 arg2Of cases,In
R15161 T19194 T19193 arg1Of cases,most
R15162 T19196 T19197 arg1Of experiments,were
R15163 T19196 T19198 arg2Of experiments,reproduced
R15164 T19198 T19192 arg1Of reproduced,In
R15165 T19198 T19195 arg1Of reproduced,","
R15166 T19198 T19197 arg2Of reproduced,were
R15167 T19198 T19199 arg1Of reproduced,with
R15168 T19201 T19199 arg2Of type,with
R15169 T19201 T19200 arg1Of type,each
R15170 T19201 T19202 arg1Of type,of
R15171 T19201 T19207 arg1Of type,with
R15172 T19206 T19202 arg2Of population,of
R15173 T19206 T19203 arg2Of population,purified
R15174 T19206 T19204 arg1Of population,CD4+
R15175 T19206 T19205 arg1Of population,T cell
R15176 T19209 T19207 arg2Of results,with
R15177 T19209 T19208 arg1Of results,similar
R15178 T19209 T19210 arg2Of results,obtained
R15179 T19212 T19211 arg1Of DCs,Splenic
R15180 T19212 T19213 arg1Of DCs,were
R15181 T19212 T19214 arg2Of DCs,prepared
R15182 T19214 T19213 arg2Of prepared,were
R15183 T19214 T19215 arg1Of prepared,as
R15184 T19214 T19217 arg1Of prepared,(
R15185 T19214 T19224 arg1Of prepared,and
R15186 T19216 T19215 arg2Of described,as
R15187 T19219 T19217 arg2Of et al.,(
R15188 T19219 T19218 arg1Of et al.,Hosken
R15189 T19219 T19220 arg1Of et al.,","
R15190 T19221 T19220 arg2Of 1995,","
R15191 T19222 T19217 arg3Of ),(
R15192 T19224 T19223 arg1Of and,","
R15193 T19228 T19225 arg1Of cells,sort
R15194 T19228 T19226 arg2Of cells,purified
R15195 T19228 T19227 arg1Of cells,CD11c+
R15196 T19228 T19229 arg1Of cells,were
R15197 T19228 T19230 arg2Of cells,added
R15198 T19230 T19224 arg2Of added,and
R15199 T19230 T19229 arg2Of added,were
R15200 T19230 T19231 arg1Of added,to
R15201 T19234 T19231 arg2Of culture,to
R15202 T19234 T19232 arg1Of culture,the
R15203 T19234 T19233 arg1Of culture,T cell
R15204 T19238 T19235 arg2Of T cells,Purified
R15205 T19238 T19236 arg1Of T cells,DO11.10
R15206 T19238 T19237 arg1Of T cells,CD4+
R15207 T19238 T19239 arg1Of T cells,(
R15208 T19238 T19245 arg1Of T cells,were
R15209 T19238 T19246 arg2Of T cells,cultured
R15210 T19240 T19239 arg2Of 1,(
R15211 T19240 T19241 arg1Of 1,×
R15212 T19243 T19241 arg2Of cells/ml,×
R15213 T19243 T19242 arg1Of cells/ml,105
R15214 T19244 T19239 arg3Of ),(
R15215 T19246 T19245 arg2Of cultured,were
R15216 T19246 T19247 arg1Of cultured,as
R15217 T19246 T19255 arg1Of cultured,","
R15218 T19246 T19256 arg1Of cultured,in
R15219 T19246 T19269 arg1Of cultured,","
R15220 T19246 T19270 arg1Of cultured,with
R15221 T19247 T19248 arg1Of as,before
R15222 T19247 T19249 arg1Of as,(
R15223 T19251 T19249 arg2Of et al.,(
R15224 T19251 T19250 arg1Of et al.,Hosken
R15225 T19251 T19252 arg1Of et al.,","
R15226 T19253 T19252 arg2Of 1995,","
R15227 T19254 T19249 arg3Of ),(
R15228 T19259 T19256 arg2Of volume,in
R15229 T19259 T19257 arg1Of volume,a
R15230 T19259 T19258 arg1Of volume,total
R15231 T19259 T19260 arg1Of volume,of
R15232 T19259 T19265 arg1Of volume,in
R15233 T19264 T19260 arg2Of medium,of
R15234 T19264 T19261 arg1Of medium,1
R15235 T19264 T19262 arg1Of medium,ml
R15236 T19264 T19263 arg1Of medium,cRPMI
R15237 T19268 T19265 arg2Of plate,in
R15238 T19268 T19266 arg1Of plate,a
R15239 T19268 T19267 arg1Of plate,48-well
R15240 T19272 T19271 arg1Of DCs,splenic
R15241 T19272 T19273 arg1Of DCs,(
R15242 T19272 T19280 arg1Of DCs,and
R15243 T19274 T19275 arg1Of 2,×
R15244 T19276 T19275 arg2Of 104,×
R15245 T19277 T19273 arg2Of cells/ml,(
R15246 T19277 T19274 arg1Of cells/ml,2
R15247 T19277 T19276 arg1Of cells/ml,104
R15248 T19278 T19273 arg3Of ),(
R15249 T19280 T19270 arg2Of and,with
R15250 T19280 T19279 arg1Of and,","
R15251 T19282 T19280 arg2Of amounts,and
R15252 T19282 T19281 arg1Of amounts,varying
R15253 T19282 T19283 arg1Of amounts,of
R15254 T19282 T19286 arg1Of amounts,of
R15255 T19283 T19285 arg1Of of,and
R15256 T19284 T19283 arg2Of OVA,of
R15257 T19286 T19285 arg2Of of,and
R15258 T19287 T19286 arg2Of IL-12,of
R15259 T19289 T19288 arg1Of differentiation,APC-independent
R15260 T19289 T19290 arg1Of differentiation,of
R15261 T19289 T19294 arg1Of differentiation,into
R15262 T19289 T19299 arg1Of differentiation,used
R15263 T19293 T19290 arg2Of T cells,of
R15264 T19293 T19291 arg1Of T cells,naive
R15265 T19293 T19292 arg1Of T cells,CD4+
R15266 T19295 T19296 arg1Of Th1,and
R15267 T19297 T19296 arg2Of Th2,and
R15268 T19298 T19294 arg2Of cells,into
R15269 T19298 T19295 arg1Of cells,Th1
R15270 T19298 T19297 arg1Of cells,Th2
R15271 T19299 T19310 arg1Of used,and
R15272 T19300 T19299 arg2Of stimulation,used
R15273 T19300 T19301 arg1Of stimulation,with
R15274 T19302 T19303 arg1Of anti-CD3,and
R15275 T19303 T19301 arg2Of and,with
R15276 T19304 T19305 arg1Of anti-CD28,and
R15277 T19306 T19305 arg2Of appropriate,and
R15278 T19308 T19303 arg2Of conditions,and
R15279 T19308 T19304 arg1Of conditions,anti-CD28
R15280 T19308 T19306 arg1Of conditions,appropriate
R15281 T19308 T19307 arg1Of conditions,cytokine
R15282 T19310 T19309 arg1Of and,","
R15283 T19312 T19313 arg1Of Th1,and
R15284 T19314 T19313 arg2Of Th2,and
R15285 T19315 T19311 arg1Of cells,control
R15286 T19315 T19312 arg1Of cells,Th1
R15287 T19315 T19314 arg1Of cells,Th2
R15288 T19315 T19316 arg1Of cells,were
R15289 T19315 T19317 arg2Of cells,cultured
R15290 T19317 T19310 arg2Of cultured,and
R15291 T19317 T19316 arg2Of cultured,were
R15292 T19317 T19318 arg1Of cultured,as
R15293 T19319 T19318 arg2Of described,as
R15294 T19319 T19320 arg1Of described,before
R15295 T19323 T19322 arg1Of et al.,Hosken
R15296 T19323 T19324 arg1Of et al.,","
R15297 T19323 T19326 arg1Of et al.,;
R15298 T19325 T19324 arg2Of 1995,","
R15299 T19326 T19320 arg2Of ;,before
R15300 T19326 T19321 arg2Of ;,(
R15301 T19327 T19326 arg2Of Shoemaker,;
R15302 T19327 T19328 arg1Of Shoemaker,et al.
R15303 T19327 T19329 arg1Of Shoemaker,","
R15304 T19330 T19329 arg2Of 2006,","
R15305 T19331 T19321 arg3Of ),(
R15306 T19333 T19332 arg1Of conditions,Culture
R15307 T19333 T19334 arg1Of conditions,for
R15308 T19333 T19337 arg1Of conditions,were
R15309 T19336 T19334 arg2Of cells,for
R15310 T19336 T19335 arg1Of cells,Th17
R15311 T19337 T19338 arg1Of were,as
R15312 T19339 T19338 arg2Of described,as
R15313 T19339 T19340 arg1Of described,before
R15314 T19343 T19340 arg2Of et al.,before
R15315 T19343 T19341 arg2Of et al.,(
R15316 T19343 T19342 arg1Of et al.,Veldhoen
R15317 T19343 T19344 arg1Of et al.,","
R15318 T19345 T19344 arg2Of 2006,","
R15319 T19346 T19341 arg3Of ),(
R15320 T19349 T19350 arg1Of Th1,and
R15321 T19351 T19350 arg2Of Th2,and
R15322 T19352 T19349 arg1Of cells,Th1
R15323 T19352 T19351 arg1Of cells,Th2
R15324 T19352 T19353 arg1Of cells,could
R15325 T19352 T19354 arg1Of cells,be
R15326 T19352 T19355 arg2Of cells,differentiated
R15327 T19355 T19353 arg2Of differentiated,could
R15328 T19355 T19354 arg2Of differentiated,be
R15329 T19355 T19356 arg1Of differentiated,in
R15330 T19355 T19360 arg1Of differentiated,(
R15331 T19355 T19377 arg1Of differentiated,but
R15332 T19357 T19358 arg1Of cRPMI,or
R15333 T19358 T19356 arg2Of or,in
R15334 T19359 T19358 arg2Of IMDM,or
R15335 T19362 T19361 arg1Of et al.,Hosken
R15336 T19362 T19363 arg1Of et al.,","
R15337 T19362 T19365 arg1Of et al.,;
R15338 T19364 T19363 arg2Of 1995,","
R15339 T19365 T19370 arg1Of ;,;
R15340 T19366 T19365 arg2Of Shoemaker,;
R15341 T19366 T19367 arg1Of Shoemaker,et al.
R15342 T19366 T19368 arg1Of Shoemaker,","
R15343 T19369 T19368 arg2Of 2006,","
R15344 T19370 T19360 arg2Of ;,(
R15345 T19371 T19370 arg2Of Veldhoen,;
R15346 T19371 T19372 arg1Of Veldhoen,et al.
R15347 T19371 T19373 arg1Of Veldhoen,","
R15348 T19374 T19373 arg2Of 2006,","
R15349 T19375 T19360 arg3Of ),(
R15350 T19377 T19347 arg1Of but,Importantly
R15351 T19377 T19348 arg1Of but,","
R15352 T19377 T19376 arg1Of but,","
R15353 T19379 T19378 arg1Of cells,Th17
R15354 T19379 T19380 arg1Of cells,were
R15355 T19379 T19382 arg2Of cells,differentiated
R15356 T19382 T19377 arg2Of differentiated,but
R15357 T19382 T19380 arg2Of differentiated,were
R15358 T19382 T19381 arg1Of differentiated,only
R15359 T19382 T19383 arg1Of differentiated,optimally
R15360 T19382 T19384 arg1Of differentiated,in
R15361 T19385 T19384 arg2Of IMDM,in
R15362 T19385 T19386 arg1Of IMDM,(
R15363 T19388 T19386 arg2Of et al.,(
R15364 T19388 T19387 arg1Of et al.,Veldhoen
R15365 T19388 T19389 arg1Of et al.,","
R15366 T19390 T19389 arg2Of 2009,","
R15367 T19391 T19386 arg3Of ),(
R15368 T19395 T19396 arg1Of U0126,or
R15369 T19396 T19393 arg2Of or,indicated
R15370 T19396 T19394 arg1Of or,","
R15371 T19396 T19398 arg1Of or,(
R15372 T19396 T19402 arg1Of or,","
R15373 T19397 T19396 arg2Of PD184352,or
R15374 T19400 T19398 arg2Of inhibitors,(
R15375 T19400 T19399 arg1Of inhibitors,MEK
R15376 T19401 T19398 arg3Of ),(
R15377 T19402 T19408 arg1Of ",",","
R15378 T19403 T19402 arg2Of SB203580,","
R15379 T19403 T19404 arg1Of SB203580,(
R15380 T19406 T19404 arg2Of inhibitor,(
R15381 T19406 T19405 arg1Of inhibitor,p38
R15382 T19407 T19404 arg3Of ),(
R15383 T19408 T19415 arg1Of ",",or
R15384 T19409 T19408 arg2Of CT99021,","
R15385 T19409 T19410 arg1Of CT99021,(
R15386 T19412 T19410 arg2Of inhibitor,(
R15387 T19412 T19411 arg1Of inhibitor,GSK3β
R15388 T19413 T19410 arg3Of ),(
R15389 T19415 T19414 arg1Of or,","
R15390 T19415 T19421 arg1Of or,were
R15391 T19415 T19422 arg1Of or,present
R15392 T19418 T19415 arg2Of amount,or
R15393 T19418 T19416 arg1Of amount,a
R15394 T19418 T19417 arg1Of amount,similar
R15395 T19418 T19419 arg1Of amount,of
R15396 T19420 T19419 arg2Of DMSO,of
R15397 T19421 T19392 arg1Of were,When
R15398 T19422 T19421 arg2Of present,were
R15399 T19422 T19423 arg1Of present,in
R15400 T19425 T19423 arg2Of culture,in
R15401 T19425 T19424 arg1Of culture,the
R15402 T19427 T19426 arg1Of details,More
R15403 T19427 T19428 arg1Of details,of
R15404 T19427 T19432 arg1Of details,are
R15405 T19427 T19433 arg2Of details,provided
R15406 T19431 T19428 arg2Of conditions,of
R15407 T19431 T19429 arg1Of conditions,specific
R15408 T19431 T19430 arg1Of conditions,culture
R15409 T19433 T19432 arg2Of provided,are
R15410 T19433 T19434 arg1Of provided,in
R15411 T19436 T19437 arg1Of S6,and
R15412 T19437 T19434 arg2Of and,in
R15413 T19437 T19435 arg1Of and,Figures
R15414 T19438 T19437 arg2Of S7,and
R15770 T19944 T19943 arg1Of Detection,Cytokine
R15771 T19944 T19945 arg1Of Detection,by
R15772 T19946 T19947 arg1Of ICS,and
R15773 T19947 T19945 arg2Of and,by
R15774 T19948 T19947 arg2Of ELISA,and
R15775 T19951 T19952 arg1Of 5,or
R15776 T19952 T19949 arg2Of or,At
R15777 T19952 T19950 arg1Of or,day
R15778 T19953 T19952 arg2Of 7,or
R15779 T19955 T19956 arg1Of cells,were
R15780 T19955 T19957 arg2Of cells,restimulated
R15781 T19957 T19949 arg1Of restimulated,At
R15782 T19957 T19954 arg1Of restimulated,","
R15783 T19957 T19956 arg2Of restimulated,were
R15784 T19957 T19958 arg1Of restimulated,with
R15785 T19957 T19987 arg1Of restimulated,with
R15786 T19958 T19986 arg1Of with,or
R15787 T19960 T19959 arg2Of anti-CD3,immobilized
R15788 T19960 T19961 arg1Of anti-CD3,(
R15789 T19960 T19965 arg1Of anti-CD3,and
R15790 T19963 T19961 arg2Of μg/ml,(
R15791 T19963 T19962 arg1Of μg/ml,2
R15792 T19964 T19961 arg3Of ),(
R15793 T19965 T19958 arg2Of and,with
R15794 T19965 T19971 arg1Of and,(
R15795 T19966 T19965 arg2Of anti-CD28,and
R15796 T19966 T19967 arg1Of anti-CD28,(
R15797 T19969 T19967 arg2Of μg/ml,(
R15798 T19969 T19968 arg1Of μg/ml,2
R15799 T19970 T19967 arg3Of ),(
R15800 T19973 T19971 arg2Of hr,(
R15801 T19973 T19972 arg1Of hr,4
R15802 T19973 T19974 arg1Of hr,with
R15803 T19973 T19980 arg1Of hr,in
R15804 T19975 T19974 arg2Of BrefeldinA,with
R15805 T19975 T19976 arg1Of BrefeldinA,[
R15806 T19978 T19976 arg2Of μg/ml,[
R15807 T19978 T19977 arg1Of μg/ml,10
R15808 T19979 T19976 arg3Of ],[
R15809 T19984 T19980 arg2Of hr,in
R15810 T19984 T19981 arg1Of hr,the
R15811 T19984 T19982 arg1Of hr,last
R15812 T19984 T19983 arg1Of hr,2
R15813 T19985 T19971 arg3Of ),(
R15814 T19987 T19986 arg2Of with,or
R15815 T19988 T19989 arg1Of PdBU,and
R15816 T19989 T19987 arg2Of and,with
R15817 T19990 T19989 arg2Of Ionomycin,and
R15818 T19990 T19991 arg1Of Ionomycin,(
R15819 T19993 T19991 arg2Of hr,(
R15820 T19993 T19992 arg1Of hr,5
R15821 T19993 T19994 arg1Of hr,with
R15822 T19995 T19994 arg2Of BrefeldinA,with
R15823 T19995 T19996 arg1Of BrefeldinA,[
R15824 T19998 T19996 arg2Of μg/ml,[
R15825 T19998 T19997 arg1Of μg/ml,1
R15826 T19999 T19996 arg3Of ],[
R15827 T20000 T19991 arg3Of ),(
R15828 T20003 T20001 arg2Of FACS,After
R15829 T20003 T20002 arg1Of FACS,ICS
R15830 T20005 T20006 arg1Of data,were
R15831 T20005 T20007 arg2Of data,collected
R15832 T20005 T20016 arg2Of data,analyzed
R15833 T20007 T20008 arg1Of collected,on
R15834 T20007 T20015 arg1Of collected,and
R15835 T20010 T20008 arg2Of FACSCalibur,on
R15836 T20010 T20009 arg1Of FACSCalibur,a
R15837 T20010 T20011 arg1Of FACSCalibur,(
R15838 T20013 T20011 arg2Of Dickinson,(
R15839 T20013 T20012 arg1Of Dickinson,Becton
R15840 T20014 T20011 arg3Of ),(
R15841 T20015 T20001 arg1Of and,After
R15842 T20015 T20004 arg1Of and,","
R15843 T20015 T20006 arg2Of and,were
R15844 T20016 T20015 arg2Of analyzed,and
R15845 T20016 T20017 arg1Of analyzed,with
R15846 T20018 T20017 arg2Of FlowJo,with
R15847 T20018 T20019 arg1Of FlowJo,(
R15848 T20021 T20019 arg2Of Star,(
R15849 T20021 T20020 arg1Of Star,Tree
R15850 T20022 T20019 arg3Of ),(
R15851 T20024 T20023 arg2Of ELISA,For
R15852 T20026 T20027 arg1Of cells,were
R15853 T20026 T20029 arg2Of cells,restimulated
R15854 T20029 T20027 arg2Of restimulated,were
R15855 T20029 T20028 arg1Of restimulated,similarly
R15856 T20029 T20030 arg1Of restimulated,for
R15857 T20029 T20033 arg1Of restimulated,and
R15858 T20032 T20030 arg2Of hr,for
R15859 T20032 T20031 arg1Of hr,48
R15860 T20033 T20023 arg1Of and,For
R15861 T20033 T20025 arg1Of and,","
R15862 T20034 T20035 arg1Of supernatant,was
R15863 T20034 T20036 arg2Of supernatant,collected
R15864 T20034 T20038 arg2Of supernatant,analyzed
R15865 T20036 T20037 arg1Of collected,and
R15866 T20037 T20033 arg2Of and,and
R15867 T20037 T20035 arg2Of and,was
R15868 T20037 T20039 arg1Of and,for
R15869 T20038 T20037 arg2Of analyzed,and
R15870 T20040 T20041 arg1Of IL-4,","
R15871 T20041 T20044 arg1Of ",",and
R15872 T20042 T20041 arg2Of IL-10,","
R15873 T20044 T20039 arg2Of and,for
R15874 T20044 T20043 arg1Of and,","
R15875 T20044 T20046 arg1Of and,as
R15876 T20045 T20044 arg2Of IFN-γ,and
R15877 T20047 T20046 arg2Of described,as
R15878 T20047 T20048 arg1Of described,before
R15879 T20051 T20048 arg2Of et al.,before
R15880 T20051 T20049 arg2Of et al.,(
R15881 T20051 T20050 arg1Of et al.,Shoemaker
R15882 T20051 T20052 arg1Of et al.,","
R15883 T20053 T20052 arg2Of 2006,","
R15884 T20054 T20049 arg3Of ),(
R16013 T20253 T20251 arg2Of Studies,In
R16014 T20253 T20252 arg1Of Studies,Vivo
R16015 T20255 T20254 arg1Of mice,BALB/c
R16016 T20255 T20256 arg1Of mice,were
R16017 T20255 T20257 arg2Of mice,injected
R16018 T20257 T20256 arg2Of injected,were
R16019 T20257 T20258 arg1Of injected,intravenously
R16020 T20257 T20259 arg1Of injected,(
R16021 T20257 T20262 arg1Of injected,with
R16022 T20260 T20259 arg2Of i.v.,(
R16023 T20261 T20259 arg3Of ),(
R16024 T20269 T20262 arg2Of suspension,with
R16025 T20269 T20263 arg1Of suspension,a
R16026 T20269 T20264 arg1Of suspension,red
R16027 T20269 T20265 arg1Of suspension,blood
R16028 T20269 T20266 arg1Of suspension,cell-depleted
R16029 T20269 T20267 arg1Of suspension,single-cell
R16030 T20269 T20268 arg1Of suspension,spleen
R16031 T20269 T20270 arg1Of suspension,(
R16032 T20269 T20276 arg1Of suspension,(
R16033 T20269 T20282 arg1Of suspension,from
R16034 T20271 T20272 arg1Of 2.5,×
R16035 T20273 T20272 arg2Of 107,×
R16036 T20274 T20270 arg2Of cells,(
R16037 T20274 T20271 arg1Of cells,2.5
R16038 T20274 T20273 arg1Of cells,107
R16039 T20275 T20270 arg3Of ),(
R16040 T20278 T20276 arg2Of et al.,(
R16041 T20278 T20277 arg1Of et al.,Castro
R16042 T20278 T20279 arg1Of et al.,","
R16043 T20280 T20279 arg2Of 2000,","
R16044 T20281 T20276 arg3Of ),(
R16045 T20284 T20283 arg1Of WT,DO11.10
R16046 T20284 T20285 arg1Of WT,or
R16047 T20285 T20282 arg2Of or,from
R16048 T20287 T20285 arg2Of mice,or
R16049 T20287 T20286 arg1Of mice,STAT-deficient
R16050 T20290 T20288 arg2Of hr,After
R16051 T20290 T20289 arg1Of hr,48
R16052 T20292 T20293 arg1Of they,were
R16053 T20292 T20294 arg2Of they,injected
R16054 T20294 T20288 arg1Of injected,After
R16055 T20294 T20291 arg1Of injected,","
R16056 T20294 T20293 arg2Of injected,were
R16057 T20294 T20295 arg1Of injected,subcutaneously
R16058 T20294 T20296 arg1Of injected,with
R16059 T20294 T20299 arg1Of injected,with
R16060 T20296 T20298 arg1Of with,or
R16061 T20297 T20296 arg2Of PBS,with
R16062 T20299 T20298 arg2Of with,or
R16063 T20301 T20300 arg1Of protein,OVA
R16064 T20301 T20302 arg1Of protein,(
R16065 T20301 T20306 arg1Of protein,plus
R16066 T20304 T20302 arg2Of mg,(
R16067 T20304 T20303 arg1Of mg,5
R16068 T20305 T20302 arg3Of ),(
R16069 T20306 T20299 arg2Of plus,with
R16070 T20307 T20306 arg2Of LPS,plus
R16071 T20307 T20308 arg1Of LPS,(
R16072 T20310 T20308 arg2Of μg,(
R16073 T20310 T20309 arg1Of μg,5
R16074 T20311 T20308 arg3Of ),(
R16075 T20315 T20312 arg1Of nodes,The
R16076 T20315 T20313 arg1Of nodes,inguinal
R16077 T20315 T20314 arg1Of nodes,lymph
R16078 T20315 T20316 arg1Of nodes,were
R16079 T20315 T20317 arg2Of nodes,removed
R16080 T20317 T20316 arg2Of removed,were
R16081 T20317 T20319 arg1Of removed,hr
R16082 T20317 T20320 arg1Of removed,later
R16083 T20319 T20318 arg1Of hr,48
R16084 T20323 T20321 arg1Of suspension,A
R16085 T20323 T20322 arg1Of suspension,single-cell
R16086 T20323 T20324 arg1Of suspension,(
R16087 T20323 T20330 arg1Of suspension,was
R16088 T20323 T20331 arg2Of suspension,restimulated
R16089 T20328 T20324 arg2Of cells,(
R16090 T20328 T20325 arg1Of cells,1
R16091 T20328 T20326 arg1Of cells,×
R16092 T20328 T20327 arg1Of cells,106
R16093 T20329 T20324 arg3Of ),(
R16094 T20331 T20330 arg2Of restimulated,was
R16095 T20331 T20332 arg1Of restimulated,for
R16096 T20331 T20346 arg1Of restimulated,with
R16097 T20332 T20345 arg1Of for,and
R16098 T20333 T20334 arg1Of 24,or
R16099 T20335 T20334 arg2Of 48,or
R16100 T20336 T20332 arg2Of hr,for
R16101 T20336 T20333 arg1Of hr,24
R16102 T20336 T20335 arg1Of hr,48
R16103 T20336 T20337 arg1Of hr,with
R16104 T20339 T20338 arg1Of μM,1
R16105 T20339 T20340 arg1Of μM,or
R16106 T20340 T20337 arg2Of or,with
R16107 T20342 T20340 arg2Of μM,or
R16108 T20342 T20341 arg1Of μM,3
R16109 T20342 T20343 arg1Of μM,of
R16110 T20344 T20343 arg2Of OVA,of
R16111 T20346 T20345 arg2Of with,and
R16112 T20347 T20346 arg2Of BrefeldinA,with
R16113 T20347 T20348 arg1Of BrefeldinA,for
R16114 T20352 T20348 arg2Of hr,for
R16115 T20352 T20349 arg1Of hr,the
R16116 T20352 T20350 arg1Of hr,last
R16117 T20352 T20351 arg1Of hr,6
R16118 T20353 T20354 arg1Of Half,of
R16119 T20353 T20357 arg1Of Half,was
R16120 T20353 T20358 arg2Of Half,removed
R16121 T20356 T20354 arg2Of supernatant,of
R16122 T20356 T20355 arg1Of supernatant,the
R16123 T20358 T20357 arg2Of removed,was
R16124 T20358 T20359 arg1Of removed,before
R16125 T20358 T20364 arg1Of removed,for
R16126 T20361 T20359 arg2Of addition,before
R16127 T20361 T20360 arg1Of addition,the
R16128 T20361 T20362 arg1Of addition,of
R16129 T20363 T20362 arg2Of BrefeldinA,of
R16130 T20365 T20364 arg2Of use,for
R16131 T20365 T20366 arg1Of use,in
R16132 T20369 T20366 arg2Of assay,in
R16133 T20369 T20367 arg1Of assay,an
R16134 T20369 T20368 arg1Of assay,ELISA
R16135 T20371 T20370 arg1Of cells,The
R16136 T20371 T20372 arg1Of cells,were
R16137 T20371 T20373 arg2Of cells,fixed
R16138 T20371 T20375 arg2Of cells,stained
R16139 T20373 T20374 arg1Of fixed,and
R16140 T20374 T20372 arg2Of and,were
R16141 T20375 T20374 arg2Of stained,and
R16142 T20375 T20376 arg1Of stained,as
R16143 T20376 T20377 arg1Of as,before
R16144 T20379 T20378 arg1Of positive,Those
R16145 T20379 T20380 arg1Of positive,for
R16146 T20379 T20383 arg1Of positive,for
R16147 T20379 T20385 arg1Of positive,were
R16148 T20379 T20386 arg2Of positive,gated
R16149 T20380 T20382 arg1Of for,and
R16150 T20381 T20380 arg2Of KJ1-26-Bio,for
R16151 T20383 T20382 arg2Of for,and
R16152 T20384 T20383 arg2Of CD4-PerCP,for
R16153 T20386 T20385 arg2Of gated,were
R16154 T20386 T20388 arg1Of gated,and
R16155 T20388 T20387 arg1Of and,","
R16156 T20389 T20390 arg1Of IFN-γ,and
R16157 T20391 T20390 arg2Of IL-10,and
R16158 T20392 T20389 arg1Of staining,IFN-γ
R16159 T20392 T20391 arg1Of staining,IL-10
R16160 T20392 T20393 arg1Of staining,was
R16161 T20392 T20394 arg2Of staining,examined
R16162 T20392 T20399 arg2Of staining,analyzed
R16163 T20394 T20395 arg1Of examined,for
R16164 T20394 T20398 arg1Of examined,and
R16165 T20397 T20395 arg2Of population,for
R16166 T20397 T20396 arg1Of population,this
R16167 T20398 T20388 arg2Of and,and
R16168 T20398 T20393 arg2Of and,was
R16169 T20399 T20398 arg2Of analyzed,and
R16170 T20399 T20400 arg1Of analyzed,as
R16171 T20400 T20401 arg1Of as,before
R16341 T20636 T20634 arg1Of RT-PCR,Real-Time
R16342 T20636 T20635 arg1Of RT-PCR,Quantitative
R16343 T20637 T20638 arg1Of Cells,were
R16344 T20637 T20639 arg2Of Cells,harvested
R16345 T20637 T20641 arg2Of Cells,restimulated
R16346 T20637 T20663 arg2Of Cells,lysed
R16347 T20639 T20640 arg1Of harvested,and
R16348 T20640 T20638 arg2Of and,were
R16349 T20641 T20642 arg1Of restimulated,in
R16350 T20641 T20658 arg1Of restimulated,for
R16351 T20641 T20661 arg1Of restimulated,or
R16352 T20642 T20643 arg1Of in,the
R16353 T20642 T20645 arg1Of in,of
R16354 T20644 T20642 arg2Of presence,in
R16355 T20647 T20646 arg2Of anti-CD3,immobilized
R16356 T20647 T20648 arg1Of anti-CD3,(
R16357 T20647 T20652 arg1Of anti-CD3,plus
R16358 T20650 T20648 arg2Of μg/ml,(
R16359 T20650 T20649 arg1Of μg/ml,2
R16360 T20651 T20648 arg3Of ),(
R16361 T20652 T20642 arg3Of plus,in
R16362 T20653 T20652 arg2Of anti-CD28,plus
R16363 T20653 T20654 arg1Of anti-CD28,(
R16364 T20656 T20654 arg2Of μg/ml,(
R16365 T20656 T20655 arg1Of μg/ml,2
R16366 T20657 T20654 arg3Of ),(
R16367 T20660 T20658 arg2Of hr,for
R16368 T20660 T20659 arg1Of hr,3
R16369 T20661 T20640 arg2Of or,and
R16370 T20663 T20661 arg2Of lysed,or
R16371 T20663 T20662 arg1Of lysed,immediately
R16372 T20664 T20665 arg1Of RNA,was
R16373 T20664 T20666 arg2Of RNA,extracted
R16374 T20666 T20665 arg2Of extracted,was
R16375 T20666 T20667 arg1Of extracted,and
R16376 T20668 T20669 arg1Of reverse-transcribed,and
R16377 T20669 T20671 arg1Of and,was
R16378 T20669 T20672 arg2Of and,analyzed
R16379 T20670 T20669 arg2Of cDNA,and
R16380 T20672 T20667 arg2Of analyzed,and
R16381 T20672 T20671 arg2Of analyzed,was
R16382 T20672 T20673 arg1Of analyzed,for
R16383 T20675 T20673 arg2Of expression,for
R16384 T20675 T20674 arg1Of expression,the
R16385 T20675 T20676 arg1Of expression,of
R16386 T20677 T20678 arg1Of cytokines,and
R16387 T20678 T20676 arg2Of and,of
R16388 T20678 T20681 arg1Of and,by
R16389 T20680 T20678 arg2Of factors,and
R16390 T20680 T20679 arg1Of factors,transcription
R16391 T20684 T20681 arg2Of assay,by
R16392 T20684 T20682 arg1Of assay,real-time
R16393 T20684 T20683 arg1Of assay,PCR
R16394 T20684 T20685 arg1Of assay,as
R16395 T20685 T20686 arg1Of as,before
R16396 T20685 T20687 arg1Of as,(
R16397 T20689 T20687 arg2Of et al.,(
R16398 T20689 T20688 arg1Of et al.,Shoemaker
R16399 T20689 T20690 arg1Of et al.,","
R16400 T20691 T20690 arg2Of 2006,","
R16401 T20692 T20687 arg3Of ),(
R16402 T20696 T20693 arg1Of expression,Target
R16403 T20696 T20694 arg1Of expression,gene
R16404 T20696 T20695 arg1Of expression,mRNA
R16405 T20696 T20697 arg1Of expression,was
R16406 T20696 T20698 arg2Of expression,quantified
R16407 T20696 T20716 arg1Of expression,normalized
R16408 T20698 T20697 arg2Of quantified,was
R16409 T20698 T20700 arg1Of quantified,with
R16410 T20698 T20708 arg1Of quantified,with
R16411 T20698 T20715 arg1Of quantified,and
R16412 T20700 T20699 arg1Of with,either
R16413 T20700 T20707 arg1Of with,or
R16414 T20702 T20700 arg2Of Green,with
R16415 T20702 T20701 arg1Of Green,SYBR
R16416 T20702 T20703 arg1Of Green,(
R16417 T20705 T20703 arg2Of Biosystems,(
R16418 T20705 T20704 arg1Of Biosystems,Applied
R16419 T20706 T20703 arg3Of ),(
R16420 T20708 T20707 arg2Of with,or
R16421 T20710 T20708 arg2Of Mix,with
R16422 T20710 T20709 arg1Of Mix,Master
R16423 T20710 T20711 arg1Of Mix,(
R16424 T20713 T20711 arg2Of Biosystems,(
R16425 T20713 T20712 arg1Of Biosystems,Applied
R16426 T20714 T20711 arg3Of ),(
R16427 T20716 T20715 arg2Of normalized,and
R16428 T20716 T20717 arg1Of normalized,to
R16429 T20716 T20723 arg1Of normalized,","
R16430 T20716 T20724 arg1Of normalized,respectively
R16431 T20718 T20719 arg1Of ubiquitin,or
R16432 T20720 T20719 arg2Of HPRT,or
R16433 T20722 T20717 arg2Of levels,to
R16434 T20722 T20718 arg1Of levels,ubiquitin
R16435 T20722 T20720 arg1Of levels,HPRT
R16436 T20722 T20721 arg1Of levels,mRNA
R16542 T20874 T20872 arg2Of T cells,Differentiated
R16543 T20874 T20873 arg1Of T cells,CD4+
R16544 T20874 T20875 arg1Of T cells,were
R16545 T20874 T20876 arg2Of T cells,rested
R16546 T20874 T20886 arg1Of T cells,restimulated
R16547 T20876 T20875 arg2Of rested,were
R16548 T20876 T20877 arg1Of rested,for
R16549 T20876 T20885 arg1Of rested,and
R16550 T20879 T20877 arg2Of hr,for
R16551 T20879 T20878 arg1Of hr,5
R16552 T20879 T20880 arg1Of hr,in
R16553 T20881 T20882 arg1Of 1,%
R16554 T20884 T20880 arg2Of medium,in
R16555 T20884 T20881 arg1Of medium,1
R16556 T20884 T20883 arg1Of medium,FCS-containing
R16557 T20886 T20885 arg2Of restimulated,and
R16558 T20886 T20887 arg1Of restimulated,as
R16559 T20888 T20887 arg2Of described,as
R16560 T20888 T20889 arg1Of described,for
R16561 T20891 T20889 arg2Of experiments,for
R16562 T20891 T20890 arg1Of experiments,specific
R16563 T20893 T20892 arg1Of lysates,Cell
R16564 T20893 T20894 arg1Of lysates,were
R16565 T20893 T20895 arg2Of lysates,prepared
R16566 T20895 T20894 arg2Of prepared,were
R16567 T20898 T20897 arg1Of amounts,equal
R16568 T20898 T20899 arg1Of amounts,of
R16569 T20898 T20901 arg1Of amounts,were
R16570 T20898 T20902 arg2Of amounts,separated
R16571 T20900 T20899 arg2Of protein,of
R16572 T20902 T20901 arg2Of separated,were
R16573 T20902 T20906 arg1Of separated,and
R16574 T20904 T20902 arg1Of SDS-PAGE,separated
R16575 T20904 T20903 arg2Of SDS-PAGE,by
R16576 T20906 T20894 modOf and,were
R16577 T20906 T20896 arg1Of and,","
R16578 T20906 T20905 arg1Of and,","
R16579 T20907 T20908 arg1Of phosphorylated,or
R16580 T20909 T20908 arg2Of total,or
R16581 T20910 T20911 arg1Of ERK,and
R16582 T20911 T20907 arg1Of and,phosphorylated
R16583 T20911 T20909 arg1Of and,total
R16584 T20911 T20913 arg1Of and,were
R16585 T20911 T20914 arg2Of and,detected
R16586 T20912 T20911 arg2Of actin,and
R16587 T20914 T20906 arg2Of detected,and
R16588 T20914 T20913 arg2Of detected,were
R16589 T20914 T20915 arg1Of detected,as
R16590 T20916 T20915 arg2Of described,as
R16591 T20916 T20917 arg1Of described,before
R16592 T20920 T20917 arg2Of et al.,before
R16593 T20920 T20918 arg2Of et al.,(
R16594 T20920 T20919 arg1Of et al.,Beinke
R16595 T20920 T20921 arg1Of et al.,","
R16596 T20922 T20921 arg2Of 2004,","
R16597 T20923 T20918 arg3Of ),(
R3767 T5037 T5036 arg1Of Production,IL-10
R3768 T5037 T5038 arg1Of Production,by
R3769 T5037 T5041 arg1Of Production,Is
R3770 T5037 T5042 arg1Of Production,Dependent
R3771 T5040 T5038 arg2Of Cells,by
R3772 T5040 T5039 arg1Of Cells,Th1

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T15740 26133-26137 Anaphor denotes this
T15741 26005-26012 Antecedent denotes induced
T15742 28325-28328 Anaphor denotes its
T15743 28275-28280 Antecedent denotes IL-10
T15744 29351-29354 Anaphor denotes its
T15745 29206-29211 Antecedent denotes c-maf
T3502 8271-8286 Anaphor denotes this expression
T3503 8233-8243 Antecedent denotes expression
T3504 8820-8841 Anaphor denotes other soluble factors
T3505 8850-8854 Antecedent denotes IL-2
T3506 8858-8863 Antecedent denotes TGF-β
T12456 19446-19450 Anaphor denotes this
T12457 19409-19417 Antecedent denotes resulted
T12458 19849-19853 Anaphor denotes this
T12459 19745-19758 Antecedent denotes transcription
T12460 20569-20584 Anaphor denotes this expression
T12461 20456-20471 Antecedent denotes mRNA expression
T12462 20814-20819 Anaphor denotes which
T12463 20737-20747 Antecedent denotes expression
R12579 T15740 T15741 boundBy this,induced
R12580 T15742 T15743 boundBy its,IL-10
R12581 T15744 T15745 boundBy its,c-maf
R2723 T3502 T3503 boundBy this expression,expression
R2724 T3504 T3505 boundBy other soluble factors,IL-2
R2725 T3504 T3506 boundBy other soluble factors,TGF-β
R9722 T12456 T12457 boundBy this,resulted
R9723 T12458 T12459 boundBy this,transcription
R9724 T12460 T12461 boundBy this expression,mRNA expression
R9725 T12462 T12463 boundBy which,expression

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T365 0-14 NNP denotes Interleukin-10
T366 15-25 NNP denotes Production
T367 26-28 IN denotes by
T368 29-32 NNP denotes Th1
T369 33-38 NNP denotes Cells
T370 39-47 VBZ denotes Requires
T371 48-70 JJ denotes Interleukin-12-Induced
T372 71-76 NNP denotes STAT4
T373 77-90 NNP denotes Transcription
T374 91-97 NNP denotes Factor
T375 98-101 CC denotes and
T376 102-105 NNP denotes ERK
T377 106-109 NNP denotes MAP
T378 110-116 NNP denotes Kinase
T379 117-127 NNP denotes Activation
T380 128-130 IN denotes by
T381 131-135 NNP denotes High
T382 136-143 NNP denotes Antigen
T383 144-148 NNP denotes Dose
T384 160-167 NNP denotes Summary
T385 168-171 NNP denotes CD4
T386 171-172 VBD denotes +
T387 173-174 NNP denotes T
T388 175-180 NNS denotes cells
T389 181-190 VBG denotes producing
T390 191-205 JJ denotes interleukin-10
T391 206-207 -LRB- denotes (
T392 207-212 NNP denotes IL-10
T393 212-213 -RRB- denotes )
T394 214-217 CC denotes and
T395 218-230 JJ denotes interferon-γ
T396 231-232 -LRB- denotes (
T397 232-237 JJ denotes IFN-γ
T398 237-238 -RRB- denotes )
T399 239-242 VBP denotes are
T400 243-251 VBN denotes reported
T401 252-254 IN denotes in
T402 255-262 JJ denotes chronic
T403 263-273 NNS denotes infections
T404 273-274 . denotes .
T405 275-282 RB denotes However
T406 282-283 , denotes ,
T407 284-287 DT denotes the
T408 288-295 NNS denotes signals
T409 296-300 WDT denotes that
T410 301-307 VBP denotes direct
T411 308-311 DT denotes the
T412 312-323 NN denotes development
T413 324-326 IN denotes of
T414 327-342 JJ denotes IL-10-producing
T415 343-344 NNP denotes T
T416 345-351 NN denotes helper
T417 352-353 CD denotes 1
T418 354-355 -LRB- denotes (
T419 355-358 NN denotes Th1
T420 358-359 -RRB- denotes )
T421 360-365 NNS denotes cells
T422 366-369 VBP denotes are
T423 370-379 JJ denotes undefined
T424 379-380 . denotes .
T425 381-383 PRP denotes We
T426 384-390 VBD denotes showed
T427 391-395 IN denotes that
T428 396-407 NN denotes development
T429 408-410 IN denotes of
T430 411-426 JJ denotes IL-10-producing
T431 427-430 JJ denotes Th1
T432 431-436 NNS denotes cells
T433 437-445 VBN denotes required
T434 446-450 JJ denotes high
T435 451-452 NNP denotes T
T436 453-457 NN denotes cell
T437 458-466 NN denotes receptor
T438 467-468 -LRB- denotes (
T439 468-471 NNP denotes TCR
T440 471-472 -RRB- denotes )
T441 473-481 NN denotes ligation
T442 481-482 , denotes ,
T443 483-492 VBD denotes sustained
T444 493-497 CD denotes ERK1
T445 498-501 CC denotes and
T446 502-506 CD denotes ERK2
T447 507-510 NNP denotes MAP
T448 511-518 NNS denotes kinases
T449 519-534 NN denotes phosphorylation
T450 534-535 , denotes ,
T451 536-539 CC denotes and
T452 540-553 JJ denotes IL-12-induced
T453 554-559 CD denotes STAT4
T454 560-573 NN denotes transcription
T455 574-580 NN denotes factor
T456 581-591 NN denotes activation
T457 591-592 . denotes .
T458 593-601 VBN denotes Repeated
T459 602-605 NNP denotes TCR
T460 606-616 VBG denotes triggering
T461 617-620 VBN denotes led
T462 621-623 TO denotes to
T463 624-632 JJ denotes enhanced
T464 633-638 NN denotes IL-10
T465 639-649 NN denotes production
T466 650-652 IN denotes by
T467 653-656 JJ denotes Th1
T468 657-662 NNS denotes cells
T469 662-663 , denotes ,
T470 664-667 CC denotes and
T471 668-677 VBD denotes continued
T472 678-683 JJ denotes IL-12
T473 684-690 NN denotes action
T474 691-694 CC denotes and
T475 695-704 JJ denotes high-dose
T476 705-708 NNP denotes TCR
T477 709-718 VBG denotes signaling
T478 719-723 VBD denotes were
T479 724-732 VBN denotes required
T480 733-736 IN denotes for
T481 737-740 DT denotes the
T482 741-752 NN denotes development
T483 753-756 CC denotes and
T484 757-768 NN denotes maintenance
T485 769-771 IN denotes of
T486 772-787 JJ denotes IL-10-producing
T487 788-791 JJ denotes Th1
T488 792-797 NNS denotes cells
T489 797-798 . denotes .
T490 799-807 IN denotes Although
T491 808-811 NNP denotes Th1
T492 811-812 , denotes ,
T493 813-816 NNP denotes Th2
T494 816-817 , denotes ,
T495 818-821 CC denotes and
T496 822-826 NNP denotes Th17
T497 827-832 NNS denotes cells
T498 833-840 VBP denotes require
T499 841-844 DT denotes the
T500 845-855 NN denotes activation
T501 856-858 IN denotes of
T502 859-867 JJ denotes distinct
T503 868-873 NNS denotes STATs
T504 874-877 IN denotes for
T505 878-883 PRP$ denotes their
T506 884-899 NN denotes differentiation
T507 899-900 , denotes ,
T508 901-911 NN denotes activation
T509 912-914 IN denotes of
T510 915-919 CD denotes ERK1
T511 920-923 CC denotes and
T512 924-928 CD denotes ERK2
T513 929-932 VBD denotes was
T514 933-934 DT denotes a
T515 935-941 JJ denotes common
T516 942-953 NN denotes requirement
T517 954-957 IN denotes for
T518 958-968 NN denotes production
T519 969-971 IN denotes of
T520 972-977 NN denotes IL-10
T521 978-980 IN denotes by
T522 981-984 DT denotes all
T523 985-987 NNP denotes Th
T524 988-992 NN denotes cell
T525 993-1000 NNS denotes subsets
T526 1000-1001 . denotes .
T527 1002-1007 NN denotes IL-10
T528 1008-1018 NN denotes expression
T529 1019-1023 RB denotes also
T530 1024-1034 VBN denotes correlated
T531 1035-1039 IN denotes with
T532 1040-1045 JJ denotes c-maf
T533 1046-1056 NN denotes expression
T534 1056-1057 . denotes .
T535 1058-1065 IN denotes Despite
T536 1066-1072 VBG denotes having
T537 1073-1081 JJ denotes distinct
T538 1082-1091 NNS denotes functions
T539 1092-1094 IN denotes in
T540 1095-1105 NN denotes protection
T541 1106-1113 IN denotes against
T542 1114-1123 NNS denotes pathogens
T543 1123-1124 , denotes ,
T544 1125-1128 DT denotes all
T545 1129-1131 NNP denotes Th
T546 1132-1137 NNS denotes cells
T547 1138-1143 VBP denotes share
T548 1144-1147 DT denotes the
T549 1148-1157 JJ denotes important
T550 1158-1162 NN denotes task
T551 1163-1165 IN denotes of
T552 1166-1177 VBG denotes controlling
T553 1178-1191 JJ denotes overexuberant
T554 1192-1198 JJ denotes immune
T555 1199-1208 NNS denotes responses
T556 1209-1211 IN denotes by
T557 1212-1217 NNS denotes means
T558 1218-1220 IN denotes of
T559 1221-1226 JJ denotes IL-10
T560 1227-1237 NN denotes production
T561 1237-1238 . denotes .
T1192 1253-1267 NNP denotes Interleukin-10
T1193 1268-1269 -LRB- denotes (
T1194 1269-1274 NNP denotes IL-10
T1195 1274-1275 -RRB- denotes )
T1196 1276-1278 VBZ denotes is
T1197 1279-1280 DT denotes a
T1198 1281-1289 NN denotes cytokine
T1199 1290-1294 IN denotes with
T1200 1295-1300 JJ denotes broad
T1201 1301-1318 JJ denotes anti-inflammatory
T1202 1319-1329 NNS denotes properties
T1203 1330-1334 WDT denotes that
T1204 1335-1343 VBZ denotes inhibits
T1205 1344-1354 NN denotes macrophage
T1206 1355-1358 CC denotes and
T1207 1359-1368 JJ denotes dendritic
T1208 1369-1373 NN denotes cell
T1209 1374-1375 -LRB- denotes (
T1210 1375-1377 NNP denotes DC
T1211 1377-1378 -RRB- denotes )
T1212 1379-1387 NN denotes function
T1213 1388-1389 -LRB- denotes (
T1214 1389-1394 NNP denotes Moore
T1215 1395-1397 FW denotes et
T1216 1398-1401 FW denotes al.
T1217 1401-1402 , denotes ,
T1218 1403-1407 CD denotes 2001
T1219 1407-1408 -RRB- denotes )
T1220 1408-1409 . denotes .
T1221 1410-1415 JJ denotes IL-10
T1222 1416-1422 NNS denotes limits
T1223 1423-1426 DT denotes the
T1224 1427-1433 JJ denotes immune
T1225 1434-1437 CC denotes and
T1226 1438-1450 JJ denotes inflammatory
T1227 1451-1460 NNS denotes responses
T1228 1461-1463 TO denotes to
T1229 1464-1473 NNS denotes pathogens
T1230 1474-1477 CC denotes and
T1231 1478-1481 NN denotes gut
T1232 1482-1487 NNS denotes flora
T1233 1488-1491 CC denotes and
T1234 1492-1500 VBZ denotes prevents
T1235 1501-1507 NN denotes damage
T1236 1508-1510 TO denotes to
T1237 1511-1514 DT denotes the
T1238 1515-1519 NN denotes host
T1239 1520-1521 -LRB- denotes (
T1240 1521-1526 NNP denotes Moore
T1241 1527-1529 FW denotes et
T1242 1530-1533 FW denotes al.
T1243 1533-1534 , denotes ,
T1244 1535-1539 CD denotes 2001
T1245 1539-1540 : denotes ;
T1246 1541-1548 NNP denotes O'Garra
T1247 1549-1552 CC denotes and
T1248 1553-1559 NNP denotes Vieira
T1249 1559-1560 , denotes ,
T1250 1561-1565 CD denotes 2004
T1251 1565-1566 -RRB- denotes )
T1252 1566-1567 , denotes ,
T1253 1568-1571 CC denotes but
T1254 1572-1576 WRB denotes when
T1255 1577-1589 VBN denotes dysregulated
T1256 1590-1593 MD denotes may
T1257 1594-1600 VB denotes result
T1258 1601-1603 IN denotes in
T1259 1604-1611 JJ denotes chronic
T1260 1612-1621 NN denotes infection
T1261 1622-1623 -LRB- denotes (
T1262 1623-1629 NNP denotes Brooks
T1263 1630-1632 FW denotes et
T1264 1633-1636 FW denotes al.
T1265 1636-1637 , denotes ,
T1266 1638-1642 CD denotes 2006
T1267 1642-1643 : denotes ;
T1268 1644-1651 NNP denotes Ejrnaes
T1269 1652-1654 FW denotes et
T1270 1655-1658 FW denotes al.
T1271 1658-1659 , denotes ,
T1272 1660-1664 CD denotes 2006
T1273 1664-1665 : denotes ;
T1274 1666-1671 NNP denotes Moore
T1275 1672-1674 FW denotes et
T1276 1675-1678 FW denotes al.
T1277 1678-1679 , denotes ,
T1278 1680-1684 CD denotes 2001
T1279 1684-1685 -RRB- denotes )
T1280 1685-1686 . denotes .
T1281 1687-1692 NN denotes IL-10
T1282 1693-1695 VBZ denotes is
T1283 1696-1705 VBN denotes expressed
T1284 1706-1708 IN denotes by
T1285 1709-1710 NNP denotes T
T1286 1711-1717 NN denotes helper
T1287 1718-1719 CD denotes 2
T1288 1720-1721 -LRB- denotes (
T1289 1721-1724 NN denotes Th2
T1290 1724-1725 -RRB- denotes )
T1291 1726-1731 NNS denotes cells
T1292 1731-1732 , denotes ,
T1293 1733-1734 NNP denotes B
T1294 1735-1740 NNS denotes cells
T1295 1740-1741 , denotes ,
T1296 1742-1745 NNP denotes DCs
T1297 1745-1746 , denotes ,
T1298 1747-1750 CC denotes and
T1299 1751-1762 NNS denotes macrophages
T1300 1763-1764 -LRB- denotes (
T1301 1764-1769 NNP denotes Moore
T1302 1770-1772 FW denotes et
T1303 1773-1776 FW denotes al.
T1304 1776-1777 , denotes ,
T1305 1778-1782 CD denotes 2001
T1306 1782-1783 -RRB- denotes )
T1307 1783-1784 , denotes ,
T1308 1785-1788 CC denotes and
T1309 1789-1793 RB denotes also
T1310 1794-1796 IN denotes by
T1311 1797-1800 JJ denotes Th1
T1312 1801-1806 NNS denotes cells
T1313 1807-1808 -LRB- denotes (
T1314 1808-1816 NNP denotes Anderson
T1315 1817-1819 FW denotes et
T1316 1820-1823 FW denotes al.
T1317 1823-1824 , denotes ,
T1318 1825-1829 CD denotes 2007
T1319 1829-1830 : denotes ;
T1320 1831-1842 NNP denotes Assenmacher
T1321 1843-1845 FW denotes et
T1322 1846-1849 FW denotes al.
T1323 1849-1850 , denotes ,
T1324 1851-1855 CD denotes 1994
T1325 1855-1856 : denotes ;
T1326 1857-1860 NNP denotes Del
T1327 1861-1866 NNP denotes Prete
T1328 1867-1869 FW denotes et
T1329 1870-1873 FW denotes al.
T1330 1873-1874 , denotes ,
T1331 1875-1879 CD denotes 1993
T1332 1879-1880 : denotes ;
T1333 1881-1887 NNP denotes Gerosa
T1334 1888-1890 FW denotes et
T1335 1891-1894 FW denotes al.
T1336 1894-1895 , denotes ,
T1337 1896-1900 CD denotes 1996
T1338 1900-1901 : denotes ;
T1339 1902-1910 NNP denotes Jankovic
T1340 1911-1913 FW denotes et
T1341 1914-1917 FW denotes al.
T1342 1917-1918 , denotes ,
T1343 1919-1923 CD denotes 2007
T1344 1923-1924 : denotes ;
T1345 1925-1935 NNP denotes Pohl-Koppe
T1346 1936-1938 FW denotes et
T1347 1939-1942 FW denotes al.
T1348 1942-1943 , denotes ,
T1349 1944-1948 CD denotes 1998
T1350 1948-1949 -RRB- denotes )
T1351 1950-1953 CC denotes and
T1352 1954-1955 -LRB- denotes (
T1353 1955-1963 VBN denotes reviewed
T1354 1964-1966 IN denotes in
T1355 1967-1974 NNP denotes O'Garra
T1356 1975-1978 CC denotes and
T1357 1979-1985 NNP denotes Vieira
T1358 1985-1986 , denotes ,
T1359 1987-1991 CD denotes 2007
T1360 1991-1992 : denotes ;
T1361 1993-2003 NNP denotes Trinchieri
T1362 2003-2004 , denotes ,
T1363 2005-2009 CD denotes 2007
T1364 2009-2010 -RRB- denotes )
T1365 2010-2011 , denotes ,
T1366 2012-2019 JJ denotes certain
T1367 2020-2030 JJ denotes regulatory
T1368 2031-2032 -LRB- denotes (
T1369 2032-2036 NNP denotes Treg
T1370 2036-2037 -RRB- denotes )
T1371 2038-2039 NNP denotes T
T1372 2040-2045 NNS denotes cells
T1373 2046-2047 -LRB- denotes (
T1374 2047-2052 NNP denotes Moore
T1375 2053-2055 FW denotes et
T1376 2056-2059 FW denotes al.
T1377 2059-2060 , denotes ,
T1378 2061-2065 CD denotes 2001
T1379 2065-2066 : denotes ;
T1380 2067-2074 NNP denotes O'Garra
T1381 2075-2078 CC denotes and
T1382 2079-2085 NNP denotes Vieira
T1383 2085-2086 , denotes ,
T1384 2087-2091 CD denotes 2004
T1385 2091-2092 : denotes ;
T1386 2093-2102 NNP denotes Roncarolo
T1387 2103-2105 FW denotes et
T1388 2106-2109 FW denotes al.
T1389 2109-2110 , denotes ,
T1390 2111-2115 CD denotes 2006
T1391 2115-2116 -RRB- denotes )
T1392 2116-2117 , denotes ,
T1393 2118-2121 CC denotes and
T1394 2122-2126 NNP denotes Th17
T1395 2127-2132 NNS denotes cells
T1396 2133-2134 -LRB- denotes (
T1397 2134-2141 NNP denotes Awasthi
T1398 2142-2144 FW denotes et
T1399 2145-2148 FW denotes al.
T1400 2148-2149 , denotes ,
T1401 2150-2154 CD denotes 2007
T1402 2154-2155 : denotes ;
T1403 2156-2166 NNP denotes Fitzgerald
T1404 2167-2169 FW denotes et
T1405 2170-2173 FW denotes al.
T1406 2173-2174 , denotes ,
T1407 2175-2179 CD denotes 2007
T1408 2179-2180 : denotes ;
T1409 2181-2189 NNP denotes McGeachy
T1410 2190-2192 FW denotes et
T1411 2193-2196 FW denotes al.
T1412 2196-2197 , denotes ,
T1413 2198-2202 CD denotes 2007
T1414 2202-2203 : denotes ;
T1415 2204-2213 NNP denotes Stumhofer
T1416 2214-2216 FW denotes et
T1417 2217-2220 FW denotes al.
T1418 2220-2221 , denotes ,
T1419 2222-2226 CD denotes 2007
T1420 2226-2227 -RRB- denotes )
T1421 2227-2228 . denotes .
T1422 2229-2231 IN denotes In
T1423 2232-2237 NN denotes vitro
T1424 2238-2243 JJ denotes human
T1425 2244-2247 NNP denotes CD4
T1426 2247-2248 NN denotes +
T1427 2249-2252 CC denotes and
T1428 2253-2256 CD denotes CD8
T1429 2256-2257 CD denotes +
T1430 2258-2259 NNP denotes T
T1431 2260-2264 NN denotes cell
T1432 2265-2271 NNS denotes clones
T1433 2271-2272 , denotes ,
T1434 2273-2275 CC denotes or
T1435 2276-2281 NN denotes mouse
T1436 2282-2285 NNP denotes CD4
T1437 2285-2286 NNP denotes +
T1438 2287-2288 NNP denotes T
T1439 2289-2294 NNS denotes cells
T1440 2295-2299 WDT denotes that
T1441 2300-2307 VBP denotes produce
T1442 2308-2312 DT denotes both
T1443 2313-2325 JJ denotes interferon-γ
T1444 2326-2327 -LRB- denotes (
T1445 2327-2332 JJ denotes IFN-γ
T1446 2332-2333 -RRB- denotes )
T1447 2334-2337 CC denotes and
T1448 2338-2343 NNP denotes IL-10
T1449 2343-2344 , denotes ,
T1450 2345-2348 MD denotes can
T1451 2349-2351 VB denotes be
T1452 2352-2366 VBN denotes differentiated
T1453 2367-2369 IN denotes by
T1454 2370-2371 NNP denotes T
T1455 2372-2376 NN denotes cell
T1456 2377-2385 NN denotes receptor
T1457 2386-2387 -LRB- denotes (
T1458 2387-2390 NNP denotes TCR
T1459 2390-2391 -RRB- denotes )
T1460 2391-2392 : denotes -
T1461 2392-2403 NN denotes stimulation
T1462 2404-2406 IN denotes in
T1463 2407-2410 DT denotes the
T1464 2411-2419 NN denotes presence
T1465 2420-2422 IN denotes of
T1466 2423-2428 NN denotes IL-12
T1467 2429-2430 -LRB- denotes (
T1468 2430-2435 NNP denotes Chang
T1469 2436-2438 FW denotes et
T1470 2439-2442 FW denotes al.
T1471 2442-2443 , denotes ,
T1472 2444-2448 CD denotes 2007
T1473 2448-2449 : denotes ;
T1474 2450-2456 NNP denotes Gerosa
T1475 2457-2459 FW denotes et
T1476 2460-2463 FW denotes al.
T1477 2463-2464 , denotes ,
T1478 2465-2469 CD denotes 1996
T1479 2469-2470 : denotes ;
T1480 2471-2478 NNP denotes Jeannin
T1481 2479-2481 FW denotes et
T1482 2482-2485 FW denotes al.
T1483 2485-2486 , denotes ,
T1484 2487-2491 CD denotes 1996
T1485 2491-2492 : denotes ;
T1486 2493-2500 NNP denotes Meyaard
T1487 2501-2503 FW denotes et
T1488 2504-2507 FW denotes al.
T1489 2507-2508 , denotes ,
T1490 2509-2513 CD denotes 1996
T1491 2513-2514 : denotes ;
T1492 2515-2524 NNP denotes Windhagen
T1493 2525-2527 FW denotes et
T1494 2528-2531 FW denotes al.
T1495 2531-2532 , denotes ,
T1496 2533-2537 CD denotes 1996
T1497 2537-2538 -RRB- denotes )
T1498 2538-2539 . denotes .
T1499 2540-2551 RB denotes Furthermore
T1500 2551-2552 , denotes ,
T1501 2553-2556 JJ denotes Th1
T1502 2557-2561 NN denotes cell
T1503 2562-2568 NNS denotes clones
T1504 2569-2580 VBG denotes coproducing
T1505 2581-2586 NNP denotes IFN-γ
T1506 2587-2590 CC denotes and
T1507 2591-2596 NNP denotes IL-10
T1508 2597-2601 VBP denotes have
T1509 2602-2606 VBN denotes been
T1510 2607-2615 VBN denotes isolated
T1511 2616-2620 IN denotes from
T1512 2621-2636 JJ denotes bronchoalveolar
T1513 2637-2643 NN denotes lavage
T1514 2644-2645 -LRB- denotes (
T1515 2645-2648 NNP denotes BAL
T1516 2648-2649 -RRB- denotes )
T1517 2650-2652 IN denotes of
T1518 2653-2659 JJ denotes active
T1519 2660-2669 JJ denotes pulmonary
T1520 2670-2682 NN denotes tuberculosis
T1521 2683-2684 -LRB- denotes (
T1522 2684-2686 NN denotes TB
T1523 2686-2687 -RRB- denotes )
T1524 2688-2696 NNS denotes patients
T1525 2697-2698 -LRB- denotes (
T1526 2698-2704 NNP denotes Gerosa
T1527 2705-2707 FW denotes et
T1528 2708-2711 FW denotes al.
T1529 2711-2712 , denotes ,
T1530 2713-2717 CD denotes 1999
T1531 2717-2718 -RRB- denotes )
T1532 2718-2719 . denotes .
T1533 2720-2725 NN denotes IL-10
T1534 2726-2736 NN denotes production
T1535 2737-2739 IN denotes by
T1536 2740-2743 JJ denotes Th1
T1537 2744-2749 NNS denotes cells
T1538 2750-2753 VBD denotes was
T1539 2754-2758 RB denotes also
T1540 2759-2767 VBN denotes reported
T1541 2768-2770 IN denotes in
T1542 2771-2778 NNS denotes animals
T1543 2779-2787 VBN denotes infected
T1544 2788-2792 IN denotes with
T1545 2793-2803 NNP denotes Toxoplasma
T1546 2804-2810 NNS denotes gondii
T1547 2811-2812 -LRB- denotes (
T1548 2812-2820 JJ denotes Jankovic
T1549 2821-2823 FW denotes et
T1550 2824-2827 FW denotes al.
T1551 2827-2828 , denotes ,
T1552 2829-2833 CD denotes 2002
T1553 2833-2834 : denotes ;
T1554 2835-2839 NNP denotes Shaw
T1555 2840-2842 FW denotes et
T1556 2843-2846 FW denotes al.
T1557 2846-2847 , denotes ,
T1558 2848-2852 CD denotes 2006
T1559 2852-2853 -RRB- denotes )
T1560 2854-2856 CC denotes or
T1561 2857-2861 IN denotes with
T1562 2862-2872 NNP denotes Leishmania
T1563 2873-2878 JJ denotes major
T1564 2879-2880 -LRB- denotes (
T1565 2880-2888 NNP denotes Anderson
T1566 2889-2891 FW denotes et
T1567 2892-2895 FW denotes al.
T1568 2895-2896 , denotes ,
T1569 2897-2901 CD denotes 2007
T1570 2901-2902 -RRB- denotes )
T1571 2903-2906 CC denotes and
T1572 2907-2912 VBN denotes shown
T1573 2913-2915 TO denotes to
T1574 2916-2918 VB denotes be
T1575 2919-2927 VBN denotes required
T1576 2928-2931 IN denotes for
T1577 2932-2942 NN denotes regulation
T1578 2943-2945 IN denotes of
T1579 2946-2949 DT denotes the
T1580 2950-2956 JJ denotes immune
T1581 2957-2965 NN denotes response
T1582 2966-2968 IN denotes in
T1583 2969-2974 DT denotes these
T1584 2975-2985 NNS denotes infections
T1585 2986-2987 -LRB- denotes (
T1586 2987-2995 NNP denotes Anderson
T1587 2996-2998 FW denotes et
T1588 2999-3002 FW denotes al.
T1589 3002-3003 , denotes ,
T1590 3004-3008 CD denotes 2007
T1591 3008-3009 : denotes ;
T1592 3010-3018 NNP denotes Jankovic
T1593 3019-3021 FW denotes et
T1594 3022-3025 FW denotes al.
T1595 3025-3026 , denotes ,
T1596 3027-3031 CD denotes 2007
T1597 3031-3032 -RRB- denotes )
T1598 3032-3033 . denotes .
T1599 3034-3037 DT denotes The
T1600 3038-3046 JJ denotes relative
T1601 3047-3054 NNS denotes amounts
T1602 3055-3057 IN denotes of
T1603 3058-3063 NN denotes IL-10
T1604 3064-3067 CC denotes and
T1605 3068-3073 JJ denotes IFN-γ
T1606 3074-3082 VBN denotes produced
T1607 3083-3085 IN denotes by
T1608 3086-3089 JJ denotes Th1
T1609 3090-3095 NNS denotes cells
T1610 3096-3099 MD denotes may
T1611 3100-3109 VB denotes influence
T1612 3110-3113 DT denotes the
T1613 3114-3121 NN denotes balance
T1614 3122-3129 IN denotes between
T1615 3130-3139 NN denotes clearance
T1616 3140-3143 CC denotes and
T1617 3144-3154 JJ denotes persistent
T1618 3155-3164 NN denotes infection
T1619 3165-3169 IN denotes with
T1620 3170-3177 JJ denotes certain
T1621 3178-3187 NNS denotes pathogens
T1622 3188-3189 -LRB- denotes (
T1623 3189-3194 NNP denotes Moore
T1624 3195-3197 FW denotes et
T1625 3198-3201 FW denotes al.
T1626 3201-3202 , denotes ,
T1627 3203-3207 CD denotes 2001
T1628 3207-3208 : denotes ;
T1629 3209-3219 NNP denotes Trinchieri
T1630 3219-3220 , denotes ,
T1631 3221-3225 CD denotes 2007
T1632 3225-3226 -RRB- denotes )
T1633 3226-3227 , denotes ,
T1634 3228-3232 RB denotes thus
T1635 3233-3244 VBG denotes determining
T1636 3245-3252 IN denotes whether
T1637 3253-3260 NN denotes chronic
T1638 3261-3270 NN denotes infection
T1639 3271-3273 CC denotes or
T1640 3274-3289 NN denotes immunopathology
T1641 3290-3296 NNS denotes ensues
T1642 3296-3297 . denotes .
T1643 3298-3301 CD denotes Th1
T1644 3301-3302 , denotes ,
T1645 3303-3306 NNP denotes Th2
T1646 3306-3307 , denotes ,
T1647 3308-3311 CC denotes and
T1648 3312-3316 NNP denotes Th17
T1649 3317-3321 NN denotes cell
T1650 3322-3331 NNS denotes responses
T1651 3332-3345 VBP denotes differentiate
T1652 3346-3351 IN denotes along
T1653 3352-3360 JJ denotes distinct
T1654 3361-3370 VBG denotes signaling
T1655 3371-3379 NNS denotes pathways
T1656 3380-3381 -LRB- denotes (
T1657 3381-3389 NNP denotes Glimcher
T1658 3390-3393 CC denotes and
T1659 3394-3400 NNP denotes Murphy
T1660 3400-3401 , denotes ,
T1661 3402-3406 CD denotes 2000
T1662 3406-3407 : denotes ;
T1663 3408-3414 NNP denotes Ivanov
T1664 3415-3417 FW denotes et
T1665 3418-3421 FW denotes al.
T1666 3421-3422 , denotes ,
T1667 3423-3427 CD denotes 2007
T1668 3427-3428 : denotes ;
T1669 3429-3439 NNP denotes Stockinger
T1670 3440-3443 CC denotes and
T1671 3444-3452 NNP denotes Veldhoen
T1672 3452-3453 , denotes ,
T1673 3454-3458 CD denotes 2007
T1674 3458-3459 -RRB- denotes )
T1675 3459-3460 . denotes .
T1676 3461-3464 CD denotes Th1
T1677 3465-3469 NN denotes cell
T1678 3470-3481 NN denotes development
T1679 3482-3490 VBZ denotes requires
T1680 3491-3497 NN denotes signal
T1681 3498-3508 NN denotes transducer
T1682 3509-3512 CC denotes and
T1683 3513-3522 NN denotes activator
T1684 3523-3525 IN denotes of
T1685 3526-3539 NN denotes transcription
T1686 3540-3541 -LRB- denotes (
T1687 3541-3545 NNP denotes STAT
T1688 3545-3546 -RRB- denotes )
T1689 3546-3547 CD denotes 1
T1690 3548-3558 NN denotes activation
T1691 3558-3559 , denotes ,
T1692 3560-3567 VBN denotes induced
T1693 3568-3570 IN denotes by
T1694 3571-3575 NN denotes type
T1695 3576-3577 PRP denotes I
T1696 3578-3581 VBP denotes IFN
T1697 3582-3584 CC denotes or
T1698 3585-3590 VBP denotes IFN-γ
T1699 3590-3591 , denotes ,
T1700 3592-3595 DT denotes the
T1701 3596-3609 NN denotes transcription
T1702 3610-3616 NN denotes factor
T1703 3617-3622 NN denotes T-box
T1704 3623-3625 CD denotes 21
T1705 3626-3627 -LRB- denotes (
T1706 3627-3632 NN denotes T-bet
T1707 3632-3633 -RRB- denotes )
T1708 3633-3634 , denotes ,
T1709 3635-3638 CC denotes and
T1710 3639-3652 JJ denotes IL-12-induced
T1711 3653-3658 CD denotes STAT4
T1712 3659-3668 VBG denotes signaling
T1713 3668-3669 , denotes ,
T1714 3670-3675 WDT denotes which
T1715 3676-3679 MD denotes can
T1716 3680-3686 NN denotes couple
T1717 3687-3691 IN denotes with
T1718 3692-3705 JJ denotes IL-18-induced
T1719 3706-3710 NNP denotes IRAK
T1720 3711-3714 CC denotes and
T1721 3715-3720 NNP denotes NF-κB
T1722 3721-3734 NN denotes transcription
T1723 3735-3742 NNS denotes factors
T1724 3743-3745 TO denotes to
T1725 3746-3751 VB denotes drive
T1726 3752-3755 DT denotes the
T1727 3756-3760 JJ denotes high
T1728 3761-3768 NNS denotes amounts
T1729 3769-3771 IN denotes of
T1730 3772-3777 JJ denotes IFN-γ
T1731 3778-3786 VBN denotes required
T1732 3787-3789 TO denotes to
T1733 3790-3799 VB denotes eradicate
T1734 3800-3813 JJ denotes intracellular
T1735 3814-3823 NNS denotes pathogens
T1736 3824-3825 -LRB- denotes (
T1737 3825-3833 NNP denotes Glimcher
T1738 3834-3837 CC denotes and
T1739 3838-3844 NNP denotes Murphy
T1740 3844-3845 , denotes ,
T1741 3846-3850 CD denotes 2000
T1742 3850-3851 -RRB- denotes )
T1743 3851-3852 . denotes .
T1744 3853-3856 CD denotes Th2
T1745 3857-3861 NN denotes cell
T1746 3862-3873 NN denotes development
T1747 3873-3874 , denotes ,
T1748 3875-3879 IN denotes with
T1749 3880-3890 NN denotes expression
T1750 3891-3893 IN denotes of
T1751 3894-3898 NN denotes IL-4
T1752 3898-3899 , denotes ,
T1753 3900-3904 NN denotes IL-5
T1754 3904-3905 , denotes ,
T1755 3906-3909 CC denotes and
T1756 3910-3915 NNP denotes IL-13
T1757 3915-3916 , denotes ,
T1758 3917-3925 VBZ denotes requires
T1759 3926-3930 NN denotes IL-4
T1760 3930-3931 , denotes ,
T1761 3932-3937 NNP denotes STAT6
T1762 3937-3938 , denotes ,
T1763 3939-3942 CC denotes and
T1764 3943-3946 DT denotes the
T1765 3947-3960 NN denotes transcription
T1766 3961-3967 NN denotes factor
T1767 3968-3972 NNP denotes GATA
T1768 3973-3980 JJ denotes binding
T1769 3981-3988 NN denotes protein
T1770 3989-3990 -LRB- denotes (
T1771 3990-3994 NNP denotes GATA
T1772 3994-3995 -RRB- denotes )
T1773 3995-3997 JJ denotes -3
T1774 3998-3999 -LRB- denotes (
T1775 3999-4007 NNP denotes Glimcher
T1776 4008-4011 CC denotes and
T1777 4012-4018 NNP denotes Murphy
T1778 4018-4019 , denotes ,
T1779 4020-4024 CD denotes 2000
T1780 4024-4025 -RRB- denotes )
T1781 4025-4026 . denotes .
T1782 4027-4030 DT denotes The
T1783 4031-4042 NN denotes development
T1784 4043-4045 IN denotes of
T1785 4046-4050 NNP denotes Th17
T1786 4051-4056 NNS denotes cells
T1787 4057-4065 VBZ denotes requires
T1788 4066-4070 NNP denotes IL-6
T1789 4070-4071 , denotes ,
T1790 4072-4077 NNP denotes TGF-β
T1791 4077-4078 , denotes ,
T1792 4079-4082 CC denotes and
T1793 4083-4086 DT denotes the
T1794 4087-4102 JJ denotes STAT3-dependent
T1795 4103-4113 NN denotes expression
T1796 4114-4116 IN denotes of
T1797 4117-4120 DT denotes the
T1798 4121-4134 NN denotes transcription
T1799 4135-4141 NN denotes factor
T1800 4142-4147 NNP denotes RORγt
T1801 4148-4149 -LRB- denotes (
T1802 4149-4155 NNP denotes Ivanov
T1803 4156-4158 FW denotes et
T1804 4159-4162 FW denotes al.
T1805 4162-4163 , denotes ,
T1806 4164-4168 CD denotes 2007
T1807 4168-4169 : denotes ;
T1808 4170-4180 NNP denotes Stockinger
T1809 4181-4184 CC denotes and
T1810 4185-4193 NNP denotes Veldhoen
T1811 4193-4194 , denotes ,
T1812 4195-4199 CD denotes 2007
T1813 4199-4200 -RRB- denotes )
T1814 4200-4201 . denotes .
T1815 4202-4205 CD denotes Th1
T1816 4206-4209 CC denotes and
T1817 4210-4213 CD denotes Th2
T1818 4214-4218 NN denotes cell
T1819 4219-4228 NNS denotes responses
T1820 4229-4232 MD denotes can
T1821 4233-4237 RB denotes also
T1822 4238-4240 VB denotes be
T1823 4241-4248 VBN denotes induced
T1824 4249-4251 IN denotes by
T1825 4252-4259 VBG denotes varying
T1826 4260-4263 DT denotes the
T1827 4264-4268 NN denotes dose
T1828 4269-4271 IN denotes of
T1829 4272-4279 NN denotes antigen
T1830 4280-4289 VBN denotes presented
T1831 4290-4292 TO denotes to
T1832 4293-4296 DT denotes the
T1833 4297-4302 JJ denotes naive
T1834 4303-4304 NNP denotes T
T1835 4305-4309 NN denotes cell
T1836 4310-4312 IN denotes by
T1837 4313-4316 DT denotes the
T1838 4317-4335 JJ denotes antigen-presenting
T1839 4336-4340 NN denotes cell
T1840 4341-4342 -LRB- denotes (
T1841 4342-4345 NNP denotes APC
T1842 4345-4346 -RRB- denotes )
T1843 4346-4347 . denotes .
T1844 4348-4355 IN denotes Whereas
T1845 4356-4360 JJ denotes high
T1846 4361-4366 NNS denotes doses
T1847 4367-4369 IN denotes of
T1848 4370-4377 NN denotes antigen
T1849 4377-4378 , denotes ,
T1850 4379-4383 IN denotes with
T1851 4384-4393 VBN denotes sustained
T1852 4394-4397 NNP denotes TCR
T1853 4398-4407 VBG denotes signaling
T1854 4408-4411 CC denotes and
T1855 4412-4432 JJ denotes extracellular-signal
T1856 4433-4442 VBN denotes regulated
T1857 4443-4444 -LRB- denotes (
T1858 4444-4447 NNP denotes ERK
T1859 4447-4448 -RRB- denotes )
T1860 4449-4466 JJ denotes mitogen-activated
T1861 4467-4474 NN denotes protein
T1862 4475-4481 NN denotes kinase
T1863 4482-4483 -LRB- denotes (
T1864 4483-4487 NNP denotes MAPK
T1865 4487-4488 -RRB- denotes )
T1866 4489-4504 NN denotes phosphorylation
T1867 4504-4505 , denotes ,
T1868 4506-4512 NN denotes result
T1869 4513-4515 IN denotes in
T1870 4516-4519 JJ denotes Th1
T1871 4520-4525 NNS denotes cells
T1872 4526-4535 VBG denotes producing
T1873 4536-4541 JJ denotes IFN-γ
T1874 4542-4545 IN denotes via
T1875 4546-4548 DT denotes an
T1876 4549-4566 JJ denotes IL-12-independent
T1877 4567-4576 NN denotes mechanism
T1878 4576-4577 , denotes ,
T1879 4578-4581 JJ denotes low
T1880 4582-4587 NNS denotes doses
T1881 4588-4590 IN denotes of
T1882 4591-4598 NN denotes antigen
T1883 4598-4599 , denotes ,
T1884 4600-4604 IN denotes with
T1885 4605-4614 NN denotes transient
T1886 4615-4619 CD denotes ERK1
T1887 4620-4623 CC denotes and
T1888 4624-4628 CD denotes ERK2
T1889 4629-4639 NN denotes activation
T1890 4639-4640 , denotes ,
T1891 4641-4646 VBP denotes favor
T1892 4647-4650 JJ denotes Th2
T1893 4651-4660 NNS denotes responses
T1894 4661-4664 CC denotes and
T1895 4665-4669 NN denotes IL-4
T1896 4670-4679 NN denotes secretion
T1897 4680-4681 -LRB- denotes (
T1898 4681-4689 JJ denotes Constant
T1899 4690-4692 FW denotes et
T1900 4693-4696 FW denotes al.
T1901 4696-4697 , denotes ,
T1902 4698-4702 CD denotes 1995
T1903 4702-4703 : denotes ;
T1904 4704-4710 NNP denotes Hosken
T1905 4711-4713 FW denotes et
T1906 4714-4717 FW denotes al.
T1907 4717-4718 , denotes ,
T1908 4719-4723 CD denotes 1995
T1909 4723-4724 : denotes ;
T1910 4725-4734 NNP denotes Jorritsma
T1911 4735-4737 FW denotes et
T1912 4738-4741 FW denotes al.
T1913 4741-4742 , denotes ,
T1914 4743-4747 CD denotes 2003
T1915 4747-4748 : denotes ;
T1916 4749-4755 NNP denotes Yamane
T1917 4756-4758 FW denotes et
T1918 4759-4762 FW denotes al.
T1919 4762-4763 , denotes ,
T1920 4764-4768 CD denotes 2005
T1921 4768-4769 -RRB- denotes )
T1922 4769-4770 . denotes .
T1923 4771-4778 IN denotes Because
T1924 4779-4782 NNP denotes Th1
T1925 4783-4786 CC denotes and
T1926 4787-4790 NNP denotes Th2
T1927 4791-4796 NNS denotes cells
T1928 4797-4802 VBP denotes cross
T1929 4803-4811 VB denotes regulate
T1930 4812-4816 DT denotes each
T1931 4817-4822 JJ denotes other
T1932 4822-4824 POS denotes 's
T1933 4825-4836 NN denotes development
T1934 4837-4840 CC denotes and
T1935 4841-4849 NN denotes function
T1936 4850-4853 CC denotes and
T1937 4854-4857 MD denotes can
T1938 4858-4866 VB denotes suppress
T1939 4867-4871 NNP denotes Th17
T1940 4872-4876 NN denotes cell
T1941 4877-4886 NNS denotes responses
T1942 4886-4887 , denotes ,
T1943 4888-4891 CC denotes and
T1944 4892-4895 DT denotes all
T1945 4896-4909 NN denotes differentiate
T1946 4910-4915 IN denotes along
T1947 4916-4924 JJ denotes distinct
T1948 4925-4934 VBG denotes signaling
T1949 4935-4943 NNS denotes pathways
T1950 4944-4945 -LRB- denotes (
T1951 4945-4953 NNP denotes Glimcher
T1952 4954-4957 CC denotes and
T1953 4958-4964 NNP denotes Murphy
T1954 4964-4965 , denotes ,
T1955 4966-4970 CD denotes 2000
T1956 4970-4971 : denotes ;
T1957 4972-4982 NNP denotes Stockinger
T1958 4983-4986 CC denotes and
T1959 4987-4995 NNP denotes Veldhoen
T1960 4995-4996 , denotes ,
T1961 4997-5001 CD denotes 2007
T1962 5001-5002 -RRB- denotes )
T1963 5002-5003 , denotes ,
T1964 5004-5009 JJ denotes IL-10
T1965 5010-5018 VBN denotes produced
T1966 5019-5021 IN denotes by
T1967 5022-5025 DT denotes all
T1968 5026-5031 DT denotes these
T1969 5032-5034 NNP denotes Th
T1970 5035-5040 NNS denotes cells
T1971 5041-5044 MD denotes may
T1972 5045-5049 RB denotes thus
T1973 5050-5053 VB denotes act
T1974 5054-5056 IN denotes as
T1975 5057-5058 DT denotes a
T1976 5059-5067 NN denotes feedback
T1977 5068-5077 NN denotes regulator
T1978 5078-5080 TO denotes to
T1979 5081-5088 VB denotes control
T1980 5089-5092 DT denotes the
T1981 5093-5102 NN denotes pathology
T1982 5103-5113 VBN denotes associated
T1983 5114-5118 IN denotes with
T1984 5119-5121 DT denotes an
T1985 5122-5135 NN denotes overexuberant
T1986 5135-5136 , denotes ,
T1987 5137-5143 IN denotes albeit
T1988 5144-5155 JJ denotes efficacious
T1989 5155-5156 , denotes ,
T1990 5157-5169 JJ denotes inflammatory
T1991 5170-5178 NN denotes response
T1992 5178-5179 . denotes .
T1993 5180-5187 IN denotes Whether
T1994 5188-5193 JJ denotes IL-10
T1995 5194-5204 NN denotes production
T1996 5205-5207 IN denotes by
T1997 5208-5213 DT denotes these
T1998 5214-5223 JJ denotes different
T1999 5224-5226 NN denotes Th
T2000 5227-5231 NN denotes cell
T2001 5232-5239 NNS denotes subsets
T2002 5240-5242 VBZ denotes is
T2003 5243-5250 VBN denotes induced
T2004 5251-5253 IN denotes by
T2005 5254-5265 JJ denotes independent
T2006 5266-5272 CC denotes and/or
T2007 5273-5279 JJ denotes common
T2008 5280-5290 NNS denotes mechanisms
T2009 5291-5293 VBZ denotes is
T2010 5294-5301 JJ denotes unknown
T2011 5301-5302 . denotes .
T2012 5303-5307 RB denotes Here
T2013 5307-5308 , denotes ,
T2014 5309-5311 PRP denotes we
T2015 5312-5318 VBD denotes showed
T2016 5319-5323 IN denotes that
T2017 5324-5326 IN denotes in
T2018 5327-5332 NN denotes vitro
T2019 5333-5348 NN denotes differentiation
T2020 5349-5351 IN denotes of
T2021 5352-5367 JJ denotes IL-10-producing
T2022 5368-5371 JJ denotes Th1
T2023 5372-5377 NNS denotes cells
T2024 5378-5382 IN denotes from
T2025 5383-5388 JJ denotes naive
T2026 5389-5392 NNP denotes CD4
T2027 5392-5393 CD denotes +
T2028 5394-5395 NNP denotes T
T2029 5396-5401 NNS denotes cells
T2030 5402-5410 VBN denotes required
T2031 5411-5424 JJ denotes IL-12-induced
T2032 5425-5430 CD denotes STAT4
T2033 5431-5440 VBG denotes signaling
T2034 5440-5441 , denotes ,
T2035 5442-5448 JJ denotes strong
T2036 5449-5452 NNP denotes TCR
T2037 5453-5463 NN denotes activation
T2038 5464-5465 -LRB- denotes (
T2039 5465-5469 JJ denotes high
T2040 5470-5477 NN denotes antigen
T2041 5478-5482 NN denotes dose
T2042 5482-5483 -RRB- denotes )
T2043 5483-5484 , denotes ,
T2044 5485-5488 CC denotes and
T2045 5489-5498 VBD denotes sustained
T2046 5499-5503 CD denotes ERK1
T2047 5504-5507 CC denotes and
T2048 5508-5512 CD denotes ERK2
T2049 5513-5528 NN denotes phosphorylation
T2050 5528-5529 . denotes .
T2051 5530-5541 RB denotes Furthermore
T2052 5541-5542 , denotes ,
T2053 5543-5545 PRP denotes we
T2054 5546-5552 VBD denotes showed
T2055 5553-5557 IN denotes that
T2056 5558-5568 NN denotes activation
T2057 5569-5571 IN denotes of
T2058 5572-5576 CD denotes ERK1
T2059 5577-5580 CC denotes and
T2060 5581-5585 CD denotes ERK2
T2061 5586-5588 VBZ denotes is
T2062 5589-5590 DT denotes a
T2063 5591-5602 NN denotes requirement
T2064 5603-5606 IN denotes for
T2065 5607-5617 NN denotes production
T2066 5618-5620 IN denotes of
T2067 5621-5626 NN denotes IL-10
T2068 5627-5629 IN denotes by
T2069 5630-5633 NNP denotes Th1
T2070 5633-5634 , denotes ,
T2071 5635-5638 NNP denotes Th2
T2072 5638-5639 , denotes ,
T2073 5640-5643 CC denotes and
T2074 5644-5648 NNP denotes Th17
T2075 5649-5653 NN denotes cell
T2076 5654-5661 NNS denotes subsets
T2077 5661-5662 . denotes .
T2078 5663-5667 DT denotes This
T2079 5668-5674 JJ denotes common
T2080 5675-5678 CC denotes but
T2081 5679-5685 RB denotes highly
T2082 5686-5695 VBN denotes regulated
T2083 5696-5703 NN denotes pathway
T2084 5704-5707 IN denotes for
T2085 5708-5713 NNP denotes IL-10
T2086 5714-5723 NN denotes induction
T2087 5724-5727 CC denotes and
T2088 5728-5739 NN denotes maintenance
T2089 5740-5747 VBZ denotes ensures
T2090 5748-5751 PRP$ denotes its
T2091 5752-5760 NN denotes function
T2092 5761-5763 IN denotes as
T2093 5764-5765 DT denotes a
T2094 5766-5774 NN denotes feedback
T2095 5775-5779 NN denotes loop
T2096 5780-5782 TO denotes to
T2097 5783-5790 VB denotes control
T2098 5791-5797 NN denotes damage
T2099 5798-5800 TO denotes to
T2100 5801-5804 DT denotes the
T2101 5805-5809 NN denotes host
T2102 5810-5813 CC denotes and
T2103 5814-5818 RB denotes also
T2104 5819-5825 VBZ denotes allows
T2105 5826-5827 DT denotes a
T2106 5828-5838 JJ denotes protective
T2107 5839-5847 NN denotes response
T2108 5848-5850 TO denotes to
T2109 5851-5856 VB denotes ensue
T2110 5857-5859 IN denotes as
T2111 5860-5867 VBN denotes opposed
T2112 5868-5870 TO denotes to
T2113 5871-5878 JJ denotes chronic
T2114 5879-5888 NN denotes infection
T2115 5888-5889 . denotes .
T3574 5900-5905 NN denotes IL-12
T3575 5906-5909 CC denotes and
T3576 5910-5914 JJ denotes High
T3577 5915-5920 NNS denotes Doses
T3578 5921-5923 IN denotes of
T3579 5924-5931 NNP denotes Antigen
T3580 5932-5938 NNP denotes Induce
T3581 5939-5942 DT denotes the
T3582 5943-5954 NNP denotes Development
T3583 5955-5957 IN denotes of
T3584 5958-5961 NNP denotes Th1
T3585 5962-5967 NNP denotes Cells
T3586 5968-5977 NNP denotes Producing
T3587 5978-5983 NNP denotes IL-10
T3588 5984-5986 TO denotes To
T3589 5987-5992 VB denotes study
T3590 5993-5996 DT denotes the
T3591 5997-6012 NN denotes differentiation
T3592 6013-6015 IN denotes of
T3593 6016-6019 JJ denotes Th1
T3594 6020-6025 NNS denotes cells
T3595 6026-6037 VBG denotes coproducing
T3596 6038-6043 NNP denotes IFN-γ
T3597 6044-6047 CC denotes and
T3598 6048-6053 NNP denotes IL-10
T3599 6053-6054 , denotes ,
T3600 6055-6057 PRP denotes we
T3601 6058-6066 VBD denotes cultured
T3602 6067-6075 VBN denotes purified
T3603 6076-6090 JJ denotes TCR-transgenic
T3604 6091-6095 NNP denotes DO11
T3605 6095-6098 CD denotes .10
T3606 6099-6104 JJ denotes naive
T3607 6105-6108 NNP denotes CD4
T3608 6108-6109 CD denotes +
T3609 6110-6111 NNP denotes T
T3610 6112-6117 NNS denotes cells
T3611 6118-6122 IN denotes with
T3612 6123-6131 JJ denotes purified
T3613 6132-6135 NNS denotes DCs
T3614 6136-6138 IN denotes as
T3615 6139-6143 NNS denotes APCs
T3616 6144-6147 CC denotes and
T3617 6148-6158 VBG denotes increasing
T3618 6159-6164 NNS denotes doses
T3619 6165-6167 IN denotes of
T3620 6168-6177 NN denotes ovalbumin
T3621 6178-6185 NN denotes peptide
T3622 6186-6193 CD denotes 323-339
T3623 6194-6195 -LRB- denotes (
T3624 6195-6198 NNP denotes OVA
T3625 6198-6199 -RRB- denotes )
T3626 6199-6200 . denotes .
T3627 6201-6208 NNP denotes Culture
T3628 6209-6213 IN denotes with
T3629 6214-6218 JJ denotes high
T3630 6219-6224 NNS denotes doses
T3631 6225-6227 IN denotes of
T3632 6228-6235 NN denotes antigen
T3633 6236-6239 IN denotes for
T3634 6240-6241 CD denotes 7
T3635 6242-6246 NNS denotes days
T3636 6247-6251 VBD denotes gave
T3637 6252-6256 NN denotes rise
T3638 6257-6259 TO denotes to
T3639 6260-6263 CD denotes Th1
T3640 6264-6269 NNS denotes cells
T3641 6270-6280 VBG denotes expressing
T3642 6281-6286 JJ denotes IFN-γ
T3643 6287-6291 IN denotes upon
T3644 6292-6305 NN denotes restimulation
T3645 6306-6307 -LRB- denotes (
T3646 6307-6315 JJ denotes Constant
T3647 6316-6318 FW denotes et
T3648 6319-6322 FW denotes al.
T3649 6322-6323 , denotes ,
T3650 6324-6328 CD denotes 1995
T3651 6328-6329 : denotes ;
T3652 6330-6336 NNP denotes Hosken
T3653 6337-6339 FW denotes et
T3654 6340-6343 FW denotes al.
T3655 6343-6344 , denotes ,
T3656 6345-6349 CD denotes 1995
T3657 6349-6350 -RRB- denotes )
T3658 6350-6351 , denotes ,
T3659 6352-6355 CC denotes but
T3660 6356-6359 RB denotes not
T3661 6360-6365 NNP denotes IL-10
T3662 6366-6367 -LRB- denotes (
T3663 6367-6373 NNP denotes Figure
T3664 6374-6377 NNP denotes S1A
T3665 6378-6387 JJ denotes available
T3666 6388-6394 NN denotes online
T3667 6394-6395 -RRB- denotes )
T3668 6395-6396 . denotes .
T3669 6397-6404 NNP denotes Culture
T3670 6405-6409 IN denotes with
T3671 6410-6413 JJ denotes low
T3672 6414-6421 NN denotes antigen
T3673 6422-6427 NNS denotes doses
T3674 6428-6433 IN denotes under
T3675 6434-6437 DT denotes the
T3676 6438-6442 JJ denotes same
T3677 6443-6453 NNS denotes conditions
T3678 6454-6457 VBD denotes led
T3679 6458-6460 TO denotes to
T3680 6461-6464 DT denotes the
T3681 6465-6480 NN denotes differentiation
T3682 6481-6483 IN denotes of
T3683 6484-6487 JJ denotes Th2
T3684 6488-6493 NNS denotes cells
T3685 6493-6494 , denotes ,
T3686 6495-6500 WDT denotes which
T3687 6501-6510 VBD denotes expressed
T3688 6511-6515 DT denotes both
T3689 6516-6520 NN denotes IL-4
T3690 6521-6524 CC denotes and
T3691 6525-6530 NN denotes IL-10
T3692 6531-6535 IN denotes upon
T3693 6536-6549 NN denotes restimulation
T3694 6550-6551 -LRB- denotes (
T3695 6551-6557 NN denotes Figure
T3696 6558-6561 CD denotes S1A
T3697 6561-6562 -RRB- denotes )
T3698 6562-6563 . denotes .
T3699 6564-6571 NNP denotes Culture
T3700 6572-6574 IN denotes of
T3701 6575-6580 JJ denotes naive
T3702 6581-6584 NNP denotes CD4
T3703 6584-6585 CD denotes +
T3704 6586-6587 NNP denotes T
T3705 6588-6593 NNS denotes cells
T3706 6594-6596 IN denotes in
T3707 6597-6599 DT denotes an
T3708 6600-6608 JJ denotes APC-free
T3709 6609-6615 NN denotes system
T3710 6616-6618 IN denotes by
T3711 6619-6630 NN denotes stimulation
T3712 6631-6635 IN denotes with
T3713 6636-6644 JJ denotes anti-CD3
T3714 6645-6648 CC denotes and
T3715 6649-6658 JJ denotes anti-CD28
T3716 6659-6669 NNS denotes antibodies
T3717 6670-6672 IN denotes in
T3718 6673-6676 DT denotes the
T3719 6677-6685 NN denotes presence
T3720 6686-6688 IN denotes of
T3721 6689-6694 NN denotes IL-12
T3722 6695-6703 VBD denotes resulted
T3723 6704-6706 IN denotes in
T3724 6707-6722 JJ denotes IFN-γ-producing
T3725 6723-6726 JJ denotes Th1
T3726 6727-6732 NNS denotes cells
T3727 6732-6733 , denotes ,
T3728 6734-6735 DT denotes a
T3729 6736-6746 NN denotes proportion
T3730 6747-6749 IN denotes of
T3731 6750-6755 WDT denotes which
T3732 6756-6766 VBD denotes coproduced
T3733 6767-6772 NNP denotes IL-10
T3734 6772-6773 , denotes ,
T3735 6774-6776 IN denotes as
T3736 6777-6780 VBD denotes did
T3737 6781-6784 CD denotes Th2
T3738 6785-6790 NNS denotes cells
T3739 6791-6800 VBG denotes resulting
T3740 6801-6805 IN denotes from
T3741 6806-6813 NN denotes culture
T3742 6814-6816 IN denotes in
T3743 6817-6821 NN denotes IL-4
T3744 6822-6823 -LRB- denotes (
T3745 6823-6829 NN denotes Figure
T3746 6830-6833 CD denotes S1B
T3747 6833-6834 -RRB- denotes )
T3748 6834-6835 . denotes .
T3749 6836-6838 TO denotes To
T3750 6839-6850 VB denotes investigate
T3751 6851-6858 IN denotes whether
T3752 6859-6862 DT denotes the
T3753 6863-6867 NN denotes lack
T3754 6868-6870 IN denotes of
T3755 6871-6876 NN denotes IL-10
T3756 6877-6885 VBN denotes produced
T3757 6886-6888 IN denotes by
T3758 6889-6892 JJ denotes Th1
T3759 6893-6898 NNS denotes cells
T3760 6899-6907 VBD denotes resulted
T3761 6908-6912 IN denotes from
T3762 6913-6923 NN denotes inhibition
T3763 6924-6926 IN denotes of
T3764 6927-6932 JJ denotes IL-10
T3765 6933-6943 NN denotes production
T3766 6944-6946 IN denotes by
T3767 6947-6950 NNP denotes DCs
T3768 6951-6954 CC denotes and
T3769 6955-6959 JJ denotes high
T3770 6960-6967 NN denotes antigen
T3771 6968-6972 NN denotes dose
T3772 6973-6975 CC denotes or
T3773 6976-6989 RB denotes alternatively
T3774 6990-6998 VBN denotes required
T3775 6999-7004 NN denotes IL-12
T3776 7004-7005 , denotes ,
T3777 7006-7008 PRP denotes we
T3778 7009-7017 VBD denotes cultured
T3779 7018-7023 JJ denotes naive
T3780 7024-7027 NNP denotes CD4
T3781 7027-7028 CD denotes +
T3782 7029-7030 NNP denotes T
T3783 7031-7036 NNS denotes cells
T3784 7037-7041 IN denotes with
T3785 7042-7052 VBG denotes increasing
T3786 7053-7058 NNS denotes doses
T3787 7059-7061 IN denotes of
T3788 7062-7069 NN denotes antigen
T3789 7070-7079 VBN denotes presented
T3790 7080-7082 IN denotes by
T3791 7083-7085 NNP denotes DC
T3792 7086-7088 IN denotes in
T3793 7089-7092 DT denotes the
T3794 7093-7101 NN denotes presence
T3795 7102-7104 IN denotes of
T3796 7105-7110 NN denotes IL-12
T3797 7110-7111 . denotes .
T3798 7112-7114 IN denotes At
T3799 7115-7118 JJ denotes low
T3800 7119-7124 NNS denotes doses
T3801 7125-7127 IN denotes of
T3802 7128-7135 NN denotes antigen
T3803 7135-7136 , denotes ,
T3804 7137-7142 NN denotes IL-12
T3805 7143-7152 VBD denotes abrogated
T3806 7153-7156 DT denotes the
T3807 7157-7168 NN denotes development
T3808 7169-7171 IN denotes of
T3809 7172-7175 JJ denotes Th2
T3810 7176-7181 NNS denotes cells
T3811 7182-7185 CC denotes and
T3812 7186-7193 VBD denotes induced
T3813 7194-7199 JJ denotes IFN-γ
T3814 7200-7210 NN denotes expression
T3815 7211-7214 CC denotes but
T3816 7215-7219 RB denotes only
T3817 7220-7223 JJ denotes low
T3818 7224-7230 NNS denotes levels
T3819 7231-7233 IN denotes of
T3820 7234-7239 NN denotes IL-10
T3821 7240-7250 NN denotes expression
T3822 7250-7251 , denotes ,
T3823 7252-7262 VBG denotes suggesting
T3824 7263-7267 IN denotes that
T3825 7268-7273 NN denotes IL-12
T3826 7274-7277 IN denotes per
T3827 7278-7280 FW denotes se
T3828 7281-7284 VBD denotes was
T3829 7285-7288 RB denotes not
T3830 7289-7299 JJ denotes sufficient
T3831 7300-7302 TO denotes to
T3832 7303-7309 VB denotes induce
T3833 7310-7321 JJ denotes significant
T3834 7322-7327 NN denotes IL-10
T3835 7328-7338 NN denotes production
T3836 7339-7341 IN denotes in
T3837 7342-7345 JJ denotes Th1
T3838 7346-7351 NNS denotes cells
T3839 7352-7353 -LRB- denotes (
T3840 7353-7359 NN denotes Figure
T3841 7360-7362 CD denotes 1A
T3842 7362-7363 -RRB- denotes )
T3843 7363-7364 . denotes .
T3844 7365-7375 RB denotes Strikingly
T3845 7375-7376 , denotes ,
T3846 7377-7379 IN denotes as
T3847 7380-7383 DT denotes the
T3848 7384-7391 NN denotes antigen
T3849 7392-7396 NN denotes dose
T3850 7397-7400 VBD denotes was
T3851 7401-7410 VBN denotes increased
T3852 7410-7411 , denotes ,
T3853 7412-7415 JJ denotes Th1
T3854 7416-7427 NNS denotes populations
T3855 7428-7434 VBN denotes driven
T3856 7435-7439 IN denotes with
T3857 7440-7445 NNP denotes IL-12
T3858 7446-7449 RB denotes now
T3859 7450-7459 VBD denotes contained
T3860 7460-7466 JJR denotes higher
T3861 7467-7474 NNS denotes numbers
T3862 7475-7477 IN denotes of
T3863 7478-7493 JJ denotes IL-10-producing
T3864 7494-7499 NNS denotes cells
T3865 7500-7501 -LRB- denotes (
T3866 7501-7507 NN denotes Figure
T3867 7508-7510 CD denotes 1A
T3868 7510-7511 -RRB- denotes )
T3869 7512-7515 CC denotes and
T3870 7516-7524 VBD denotes produced
T3871 7525-7529 RBR denotes more
T3872 7530-7535 JJ denotes IL-10
T3873 7536-7543 NN denotes protein
T3874 7544-7548 IN denotes upon
T3875 7549-7562 NN denotes restimulation
T3876 7563-7564 -LRB- denotes (
T3877 7564-7571 NNS denotes Figures
T3878 7572-7574 NNP denotes 1A
T3879 7575-7578 CC denotes and
T3880 7579-7581 NNP denotes 1B
T3881 7581-7582 -RRB- denotes )
T3882 7582-7583 . denotes .
T3883 7584-7588 RB denotes Thus
T3884 7588-7589 , denotes ,
T3885 7590-7593 DT denotes the
T3886 7594-7605 NN denotes development
T3887 7606-7608 IN denotes of
T3888 7609-7612 JJ denotes Th1
T3889 7613-7618 NNS denotes cells
T3890 7619-7628 VBG denotes producing
T3891 7629-7634 NN denotes IL-10
T3892 7635-7643 VBN denotes required
T3893 7644-7648 DT denotes both
T3894 7649-7654 NN denotes IL-12
T3895 7655-7658 CC denotes and
T3896 7659-7663 JJ denotes high
T3897 7664-7669 NNS denotes doses
T3898 7670-7672 IN denotes of
T3899 7673-7680 NN denotes antigen
T3900 7680-7681 . denotes .
T3901 7682-7685 CD denotes Th1
T3902 7686-7691 NNS denotes cells
T3903 7692-7706 VBN denotes differentiated
T3904 7707-7709 TO denotes to
T3905 7710-7717 VB denotes produce
T3906 7718-7723 JJ denotes large
T3907 7724-7731 NNS denotes amounts
T3908 7732-7734 IN denotes of
T3909 7735-7740 NNP denotes IL-10
T3910 7741-7744 CC denotes and
T3911 7745-7750 NNP denotes IFN-γ
T3912 7751-7754 CC denotes and
T3913 7755-7759 VBD denotes lost
T3914 7760-7765 PRP$ denotes their
T3915 7766-7774 NN denotes capacity
T3916 7775-7777 TO denotes to
T3917 7778-7785 VB denotes produce
T3918 7786-7790 NNP denotes IL-2
T3919 7791-7792 -LRB- denotes (
T3920 7792-7798 NNP denotes Figure
T3921 7799-7801 NNP denotes 1B
T3922 7801-7802 -RRB- denotes )
T3923 7802-7803 . denotes .
T3924 7804-7811 IN denotes Because
T3925 7812-7815 DT denotes the
T3926 7816-7824 NN denotes presence
T3927 7825-7827 IN denotes of
T3928 7828-7833 NN denotes IL-12
T3929 7834-7841 VBD denotes reduced
T3930 7842-7845 DT denotes the
T3931 7846-7859 NN denotes proliferation
T3932 7860-7862 IN denotes of
T3933 7863-7866 CD denotes CD4
T3934 7866-7867 CD denotes +
T3935 7868-7869 NNP denotes T
T3936 7870-7875 NNS denotes cells
T3937 7876-7878 IN denotes at
T3938 7879-7883 DT denotes both
T3939 7884-7888 JJ denotes high
T3940 7889-7892 CC denotes and
T3941 7893-7896 JJ denotes low
T3942 7897-7904 NN denotes antigen
T3943 7905-7910 NNS denotes doses
T3944 7911-7912 -LRB- denotes (
T3945 7912-7917 NNP denotes Table
T3946 7918-7920 NNP denotes S1
T3947 7920-7921 -RRB- denotes )
T3948 7921-7922 , denotes ,
T3949 7923-7926 CC denotes and
T3950 7927-7931 RB denotes only
T3951 7932-7935 DT denotes the
T3952 7936-7942 JJ denotes former
T3953 7943-7949 VBD denotes showed
T3954 7950-7955 JJ denotes IL-10
T3955 7956-7966 NN denotes production
T3956 7966-7967 , denotes ,
T3957 7968-7971 DT denotes the
T3958 7972-7983 NN denotes development
T3959 7984-7986 IN denotes of
T3960 7987-7991 JJ denotes high
T3961 7992-8007 JJ denotes IL-10-producing
T3962 8008-8013 NNS denotes cells
T3963 8014-8016 VBZ denotes is
T3964 8017-8021 RBS denotes most
T3965 8022-8028 JJ denotes likely
T3966 8029-8032 RB denotes not
T3967 8033-8040 VBN denotes related
T3968 8041-8043 TO denotes to
T3969 8044-8051 JJ denotes limited
T3970 8052-8056 NN denotes IL-2
T3971 8056-8057 . denotes .
T3972 8058-8063 JJ denotes Naive
T3973 8064-8067 NNP denotes CD4
T3974 8067-8068 CD denotes +
T3975 8069-8070 NNP denotes T
T3976 8071-8076 NNS denotes cells
T3977 8077-8081 IN denotes from
T3978 8082-8086 NNP denotes DO11
T3979 8086-8089 CD denotes .10
T3980 8089-8090 CD denotes /
T3981 8090-8114 JJ denotes recombination-activating
T3982 8115-8119 NN denotes gene
T3983 8120-8121 CD denotes 1
T3984 8122-8123 -LRB- denotes (
T3985 8123-8127 NN denotes Rag1
T3986 8127-8128 -RRB- denotes )
T3987 8128-8129 : denotes -
T3988 8129-8138 NN denotes deficient
T3989 8139-8146 NNS denotes animals
T3990 8146-8147 , denotes ,
T3991 8148-8156 VBN denotes cultured
T3992 8157-8161 IN denotes with
T3993 8162-8166 JJ denotes high
T3994 8167-8172 NNS denotes doses
T3995 8173-8175 IN denotes of
T3996 8176-8183 NN denotes antigen
T3997 8184-8186 IN denotes in
T3998 8187-8190 DT denotes the
T3999 8191-8199 NN denotes presence
T4000 8200-8202 IN denotes of
T4001 8203-8208 NN denotes IL-12
T4002 8208-8209 , denotes ,
T4003 8210-8214 RB denotes also
T4004 8215-8223 VBD denotes resulted
T4005 8224-8226 IN denotes in
T4006 8227-8232 NNP denotes IL-10
T4007 8233-8243 NN denotes expression
T4008 8244-8246 IN denotes by
T4009 8247-8250 JJ denotes Th1
T4010 8251-8256 NNS denotes cells
T4011 8256-8257 , denotes ,
T4012 8258-8265 VBG denotes showing
T4013 8266-8270 IN denotes that
T4014 8271-8275 DT denotes this
T4015 8276-8286 NN denotes expression
T4016 8287-8290 VBD denotes was
T4017 8291-8294 RB denotes not
T4018 8295-8304 JJ denotes dependent
T4019 8305-8307 IN denotes on
T4020 8308-8311 DT denotes the
T4021 8312-8320 NN denotes presence
T4022 8321-8323 IN denotes of
T4023 8324-8332 NN denotes effector
T4024 8333-8335 CC denotes or
T4025 8336-8342 NN denotes memory
T4026 8343-8344 NNP denotes T
T4027 8345-8350 NNS denotes cells
T4028 8351-8353 CC denotes or
T4029 8354-8358 NNP denotes Treg
T4030 8359-8364 NNS denotes cells
T4031 8365-8366 -LRB- denotes (
T4032 8366-8372 NN denotes Figure
T4033 8373-8375 CD denotes S2
T4034 8375-8376 -RRB- denotes )
T4035 8376-8377 . denotes .
T4036 8378-8386 IN denotes Although
T4037 8387-8389 PRP denotes it
T4038 8390-8393 VBZ denotes has
T4039 8394-8398 VBN denotes been
T4040 8399-8408 VBN denotes suggested
T4041 8409-8413 IN denotes that
T4042 8414-8419 NNP denotes TGF-β
T4043 8420-8423 MD denotes can
T4044 8424-8430 VB denotes induce
T4045 8431-8436 NNP denotes IL-10
T4046 8437-8439 IN denotes in
T4047 8440-8443 NNP denotes CD4
T4048 8443-8444 NNP denotes +
T4049 8445-8446 NNP denotes T
T4050 8447-8452 NNS denotes cells
T4051 8453-8454 -LRB- denotes (
T4052 8454-8460 NNP denotes Kitani
T4053 8461-8463 FW denotes et
T4054 8464-8467 FW denotes al.
T4055 8467-8468 , denotes ,
T4056 8469-8473 CD denotes 2003
T4057 8473-8474 : denotes ;
T4058 8475-8482 NNP denotes Schiott
T4059 8483-8485 FW denotes et
T4060 8486-8489 FW denotes al.
T4061 8489-8490 , denotes ,
T4062 8491-8495 CD denotes 2000
T4063 8495-8496 -RRB- denotes )
T4064 8496-8497 , denotes ,
T4065 8498-8500 PRP denotes we
T4066 8501-8506 VBD denotes found
T4067 8507-8511 IN denotes that
T4068 8512-8514 IN denotes in
T4069 8515-8525 VBG denotes developing
T4070 8526-8529 NNP denotes Th1
T4071 8530-8533 CC denotes and
T4072 8534-8537 NNP denotes Th2
T4073 8538-8543 NNS denotes cells
T4074 8544-8548 DT denotes this
T4075 8549-8552 VBD denotes was
T4076 8553-8556 RB denotes not
T4077 8557-8560 DT denotes the
T4078 8561-8565 NN denotes case
T4079 8566-8567 -LRB- denotes (
T4080 8567-8571 NNS denotes data
T4081 8572-8575 RB denotes not
T4082 8576-8581 VBN denotes shown
T4083 8581-8582 -RRB- denotes )
T4084 8582-8583 . denotes .
T4085 8584-8586 IN denotes In
T4086 8587-8591 NN denotes fact
T4087 8591-8592 , denotes ,
T4088 8593-8607 NN denotes neutralization
T4089 8608-8610 IN denotes of
T4090 8611-8616 NNP denotes TGF-β
T4091 8617-8620 VBD denotes led
T4092 8621-8623 TO denotes to
T4093 8624-8633 VBN denotes increased
T4094 8634-8639 JJ denotes IL-10
T4095 8640-8650 NN denotes production
T4096 8651-8653 IN denotes by
T4097 8654-8658 DT denotes both
T4098 8659-8660 NNP denotes T
T4099 8661-8665 NN denotes cell
T4100 8666-8673 NNS denotes subsets
T4101 8674-8675 -LRB- denotes (
T4102 8675-8681 NN denotes Figure
T4103 8682-8684 CD denotes S3
T4104 8684-8685 -RRB- denotes )
T4105 8685-8686 . denotes .
T4106 8687-8691 RB denotes Thus
T4107 8691-8692 , denotes ,
T4108 8693-8696 DT denotes the
T4109 8697-8708 NN denotes development
T4110 8709-8711 IN denotes of
T4111 8712-8727 JJ denotes IL-10-producing
T4112 8728-8731 JJ denotes Th1
T4113 8732-8737 NNS denotes cells
T4114 8738-8742 RB denotes only
T4115 8743-8751 VBD denotes depended
T4116 8752-8754 IN denotes on
T4117 8755-8758 DT denotes the
T4118 8759-8767 NN denotes presence
T4119 8768-8770 IN denotes of
T4120 8771-8776 NN denotes IL-12
T4121 8777-8785 RB denotes together
T4122 8786-8790 IN denotes with
T4123 8791-8795 JJ denotes high
T4124 8796-8803 NN denotes antigen
T4125 8804-8808 NN denotes dose
T4126 8809-8812 CC denotes and
T4127 8813-8816 RB denotes not
T4128 8817-8819 IN denotes on
T4129 8820-8825 JJ denotes other
T4130 8826-8833 JJ denotes soluble
T4131 8834-8841 NNS denotes factors
T4132 8842-8846 JJ denotes such
T4133 8847-8849 IN denotes as
T4134 8850-8854 NN denotes IL-2
T4135 8855-8857 CC denotes or
T4136 8858-8863 NN denotes TGF-β
T4137 8864-8866 CC denotes or
T4138 8867-8869 IN denotes on
T4139 8870-8873 DT denotes the
T4140 8874-8882 NN denotes presence
T4141 8883-8885 IN denotes of
T4142 8886-8891 JJ denotes other
T4143 8892-8893 NNP denotes T
T4144 8894-8898 NN denotes cell
T4145 8899-8904 NNS denotes types
T4146 8904-8905 . denotes .
T5679 8907-8912 NNP denotes IL-10
T5680 8913-8923 NNP denotes Production
T5681 8924-8926 IN denotes by
T5682 8927-8930 NNP denotes Th1
T5683 8931-8936 NNP denotes Cells
T5684 8937-8939 VBZ denotes Is
T5685 8940-8949 JJ denotes Dependent
T5686 8950-8952 IN denotes on
T5687 8953-8958 CD denotes STAT4
T5688 8959-8962 CC denotes but
T5689 8963-8966 RB denotes Not
T5690 8967-8969 IN denotes on
T5691 8970-8975 NNP denotes STAT6
T5692 8975-8976 , denotes ,
T5693 8977-8982 NNP denotes IFN-γ
T5694 8982-8983 , denotes ,
T5695 8984-8986 CC denotes or
T5696 8987-8991 NN denotes IL-4
T5697 8992-9001 VBG denotes Signaling
T5698 9002-9004 TO denotes To
T5699 9005-9012 RBR denotes further
T5700 9013-9022 VB denotes elucidate
T5701 9023-9026 DT denotes the
T5702 9027-9037 NNS denotes mechanisms
T5703 9038-9046 VBN denotes required
T5704 9047-9050 IN denotes for
T5705 9051-9054 DT denotes the
T5706 9055-9066 NN denotes development
T5707 9067-9069 IN denotes of
T5708 9070-9073 JJ denotes Th1
T5709 9074-9079 NNS denotes cells
T5710 9080-9089 VBG denotes producing
T5711 9090-9095 NNP denotes IL-10
T5712 9095-9096 , denotes ,
T5713 9097-9099 PRP denotes we
T5714 9100-9112 VBD denotes investigated
T5715 9113-9116 DT denotes the
T5716 9117-9121 NN denotes role
T5717 9122-9124 IN denotes of
T5718 9125-9130 NNP denotes STAT4
T5719 9130-9131 , denotes ,
T5720 9132-9135 CD denotes one
T5721 9136-9138 IN denotes of
T5722 9139-9142 DT denotes the
T5723 9143-9152 VBG denotes signaling
T5724 9153-9161 NNS denotes pathways
T5725 9162-9171 VBN denotes activated
T5726 9172-9174 IN denotes by
T5727 9175-9180 NNP denotes IL-12
T5728 9181-9182 -LRB- denotes (
T5729 9182-9188 NNP denotes Murphy
T5730 9189-9191 FW denotes et
T5731 9192-9195 FW denotes al.
T5732 9195-9196 , denotes ,
T5733 9197-9201 CD denotes 2000
T5734 9201-9202 -RRB- denotes )
T5735 9202-9203 . denotes .
T5736 9204-9209 JJ denotes Naive
T5737 9210-9213 NNP denotes CD4
T5738 9213-9214 NNP denotes +
T5739 9215-9219 NNP denotes D011
T5740 9219-9222 CD denotes .10
T5741 9223-9224 NNP denotes T
T5742 9225-9230 NNS denotes cells
T5743 9231-9240 NN denotes deficient
T5744 9241-9243 IN denotes in
T5745 9244-9249 NNP denotes STAT4
T5746 9250-9251 -LRB- denotes (
T5747 9251-9257 NNP denotes Ouyang
T5748 9258-9260 FW denotes et
T5749 9261-9264 FW denotes al.
T5750 9264-9265 , denotes ,
T5751 9266-9270 CD denotes 1998
T5752 9270-9271 -RRB- denotes )
T5753 9272-9276 VBD denotes were
T5754 9277-9285 VBN denotes cultured
T5755 9286-9288 IN denotes in
T5756 9289-9292 DT denotes the
T5757 9293-9301 NN denotes presence
T5758 9302-9304 IN denotes of
T5759 9305-9310 NN denotes IL-12
T5760 9311-9314 CC denotes and
T5761 9315-9318 NNP denotes OVA
T5762 9318-9319 . denotes .
T5763 9320-9325 RB denotes Again
T5764 9325-9326 , denotes ,
T5765 9327-9342 JJ denotes IL-10-producing
T5766 9343-9346 JJ denotes Th1
T5767 9347-9352 NNS denotes cells
T5768 9353-9357 VBD denotes were
T5769 9358-9372 VBN denotes differentiated
T5770 9373-9375 IN denotes at
T5771 9376-9379 DT denotes the
T5772 9380-9384 JJ denotes high
T5773 9385-9392 NN denotes antigen
T5774 9393-9397 NN denotes dose
T5775 9398-9400 IN denotes in
T5776 9401-9404 DT denotes the
T5777 9405-9413 NN denotes presence
T5778 9414-9416 IN denotes of
T5779 9417-9422 NN denotes IL-12
T5780 9423-9425 IN denotes in
T5781 9426-9430 NNP denotes DO11
T5782 9430-9433 CD denotes .10
T5783 9434-9435 NNP denotes T
T5784 9436-9441 NNS denotes cells
T5785 9442-9443 -LRB- denotes (
T5786 9443-9449 NN denotes Figure
T5787 9450-9452 NN denotes 2A
T5788 9452-9453 -RRB- denotes )
T5789 9453-9454 . denotes .
T5790 9455-9457 IN denotes In
T5791 9458-9466 NN denotes contrast
T5792 9466-9467 , denotes ,
T5793 9468-9470 IN denotes in
T5794 9471-9474 DT denotes the
T5795 9475-9482 NN denotes absence
T5796 9483-9485 IN denotes of
T5797 9486-9491 NNP denotes STAT4
T5798 9491-9492 , denotes ,
T5799 9493-9496 DT denotes the
T5800 9497-9507 NN denotes percentage
T5801 9508-9510 IN denotes of
T5802 9511-9516 NNS denotes cells
T5803 9517-9527 VBG denotes expressing
T5804 9528-9533 NNP denotes IFN-γ
T5805 9534-9537 VBD denotes was
T5806 9538-9550 RB denotes dramatically
T5807 9551-9561 VBN denotes diminished
T5808 9562-9564 IN denotes as
T5809 9565-9573 VBN denotes expected
T5810 9574-9577 CC denotes and
T5811 9578-9586 VBN denotes resulted
T5812 9587-9589 IN denotes in
T5813 9590-9592 DT denotes an
T5814 9593-9601 NN denotes increase
T5815 9602-9604 IN denotes in
T5816 9605-9608 DT denotes the
T5817 9609-9619 NN denotes percentage
T5818 9620-9622 IN denotes of
T5819 9623-9628 NNS denotes cells
T5820 9629-9639 VBG denotes expressing
T5821 9640-9644 NN denotes IL-4
T5822 9644-9645 , denotes ,
T5823 9646-9649 CC denotes but
T5824 9650-9653 RB denotes not
T5825 9654-9659 NNP denotes IL-10
T5826 9660-9661 -LRB- denotes (
T5827 9661-9667 NNP denotes Figure
T5828 9668-9670 NNP denotes 2A
T5829 9670-9671 -RRB- denotes )
T5830 9671-9672 , denotes ,
T5831 9673-9683 VBG denotes suggesting
T5832 9684-9688 IN denotes that
T5833 9689-9694 CD denotes STAT4
T5834 9695-9706 VBZ denotes contributes
T5835 9707-9709 TO denotes to
T5836 9710-9715 NNP denotes IL-10
T5837 9716-9726 NN denotes expression
T5838 9727-9729 IN denotes by
T5839 9730-9733 JJ denotes Th1
T5840 9734-9739 NNS denotes cells
T5841 9739-9740 . denotes .
T5842 9741-9748 IN denotes Because
T5843 9749-9754 NNP denotes IL-10
T5844 9755-9765 NN denotes expression
T5845 9766-9768 VBZ denotes is
T5846 9769-9779 VBN denotes associated
T5847 9780-9784 IN denotes with
T5848 9785-9787 DT denotes an
T5849 9788-9800 JJ denotes IL-4-induced
T5850 9801-9804 NN denotes Th2
T5851 9805-9809 NN denotes cell
T5852 9810-9819 NN denotes phenotype
T5853 9819-9820 , denotes ,
T5854 9821-9823 PRP denotes we
T5855 9824-9836 VBD denotes investigated
T5856 9837-9844 IN denotes whether
T5857 9845-9848 DT denotes the
T5858 9849-9864 NN denotes differentiation
T5859 9865-9867 IN denotes of
T5860 9868-9871 DT denotes the
T5861 9872-9887 JJ denotes IL-10-producing
T5862 9888-9891 JJ denotes Th1
T5863 9892-9897 NNS denotes cells
T5864 9898-9906 VBD denotes depended
T5865 9907-9909 IN denotes on
T5866 9910-9919 VBG denotes signaling
T5867 9920-9927 IN denotes through
T5868 9928-9931 DT denotes the
T5869 9932-9936 NN denotes IL-4
T5870 9937-9945 NN denotes receptor
T5871 9946-9949 IN denotes via
T5872 9950-9955 NNP denotes STAT6
T5873 9956-9966 NN denotes activation
T5874 9967-9968 -LRB- denotes (
T5875 9968-9976 NNP denotes Glimcher
T5876 9977-9980 CC denotes and
T5877 9981-9987 NNP denotes Murphy
T5878 9987-9988 , denotes ,
T5879 9989-9993 CD denotes 2000
T5880 9993-9994 : denotes ;
T5881 9995-10001 NNP denotes Murphy
T5882 10002-10004 FW denotes et
T5883 10005-10008 FW denotes al.
T5884 10008-10009 , denotes ,
T5885 10010-10014 CD denotes 2000
T5886 10014-10015 -RRB- denotes )
T5887 10015-10016 . denotes .
T5888 10017-10020 DT denotes The
T5889 10021-10028 NN denotes absence
T5890 10029-10031 IN denotes of
T5891 10032-10037 NNP denotes STAT6
T5892 10038-10041 VBD denotes did
T5893 10042-10045 RB denotes not
T5894 10046-10052 VB denotes impair
T5895 10053-10056 DT denotes the
T5896 10057-10072 NN denotes differentiation
T5897 10073-10075 IN denotes of
T5898 10076-10091 JJ denotes IL-10-producing
T5899 10092-10095 JJ denotes Th1
T5900 10096-10101 NNS denotes cells
T5901 10102-10104 IN denotes in
T5902 10105-10108 DT denotes the
T5903 10109-10117 NN denotes presence
T5904 10118-10120 IN denotes of
T5905 10121-10126 NN denotes IL-12
T5906 10127-10130 CC denotes and
T5907 10131-10134 NNP denotes OVA
T5908 10135-10136 -LRB- denotes (
T5909 10136-10142 NNP denotes Figure
T5910 10143-10145 NNP denotes 2A
T5911 10145-10146 -RRB- denotes )
T5912 10146-10147 . denotes .
T5913 10148-10150 IN denotes In
T5914 10151-10155 NN denotes fact
T5915 10155-10156 , denotes ,
T5916 10157-10158 DT denotes a
T5917 10159-10165 JJR denotes higher
T5918 10166-10176 NN denotes percentage
T5919 10177-10179 IN denotes of
T5920 10180-10195 JJ denotes STAT6-deficient
T5921 10196-10201 NNS denotes cells
T5922 10202-10210 VBN denotes compared
T5923 10211-10215 IN denotes with
T5924 10216-10218 NNP denotes WT
T5925 10219-10224 NNS denotes cells
T5926 10225-10233 VBD denotes produced
T5927 10234-10238 DT denotes both
T5928 10239-10244 NNP denotes IL-10
T5929 10245-10248 CC denotes and
T5930 10249-10254 NNP denotes IFN-γ
T5931 10255-10256 -LRB- denotes (
T5932 10256-10262 NNP denotes Figure
T5933 10263-10265 NNP denotes 2A
T5934 10265-10266 -RRB- denotes )
T5935 10266-10267 , denotes ,
T5936 10268-10273 WDT denotes which
T5937 10274-10277 MD denotes may
T5938 10278-10280 VB denotes be
T5939 10281-10284 DT denotes the
T5940 10285-10291 NN denotes result
T5941 10292-10294 IN denotes of
T5942 10295-10298 DT denotes the
T5943 10299-10303 NN denotes loss
T5944 10304-10306 IN denotes of
T5945 10307-10310 NNP denotes Th2
T5946 10311-10315 NN denotes cell
T5947 10316-10323 NN denotes control
T5948 10324-10328 IN denotes over
T5949 10329-10330 DT denotes a
T5950 10331-10334 JJ denotes Th1
T5951 10335-10339 NN denotes cell
T5952 10340-10348 NN denotes response
T5953 10348-10349 . denotes .
T5954 10350-10352 IN denotes As
T5955 10353-10361 VBN denotes expected
T5956 10361-10362 , denotes ,
T5957 10363-10367 NN denotes lack
T5958 10368-10370 IN denotes of
T5959 10371-10376 NNP denotes STAT6
T5960 10377-10386 VBD denotes abrogated
T5961 10387-10391 DT denotes both
T5962 10392-10396 NN denotes IL-4
T5963 10397-10400 CC denotes and
T5964 10401-10406 NN denotes IL-10
T5965 10407-10417 NN denotes production
T5966 10418-10420 IN denotes by
T5967 10421-10422 NNP denotes T
T5968 10423-10428 NNS denotes cells
T5969 10429-10438 VBD denotes developed
T5970 10439-10443 IN denotes with
T5971 10444-10448 NN denotes IL-4
T5972 10449-10451 CC denotes or
T5973 10452-10456 IN denotes with
T5974 10457-10460 JJ denotes low
T5975 10461-10468 NN denotes antigen
T5976 10469-10473 NN denotes dose
T5977 10474-10475 -LRB- denotes (
T5978 10475-10482 NNS denotes Figures
T5979 10483-10485 NN denotes 2B
T5980 10486-10489 CC denotes and
T5981 10490-10492 NN denotes 2C
T5982 10492-10493 -RRB- denotes )
T5983 10493-10494 . denotes .
T5984 10495-10502 RB denotes However
T5985 10502-10503 , denotes ,
T5986 10504-10506 IN denotes in
T5987 10507-10510 DT denotes the
T5988 10511-10518 NN denotes absence
T5989 10519-10521 IN denotes of
T5990 10522-10527 CD denotes STAT4
T5991 10528-10537 VBG denotes signaling
T5992 10537-10538 , denotes ,
T5993 10539-10544 NNP denotes IL-10
T5994 10545-10548 CC denotes and
T5995 10549-10553 NN denotes IL-4
T5996 10554-10564 NN denotes production
T5997 10565-10567 IN denotes by
T5998 10568-10571 JJ denotes Th2
T5999 10572-10577 NNS denotes cells
T6000 10578-10581 VBD denotes was
T6001 10582-10584 IN denotes if
T6002 10585-10593 NN denotes anything
T6003 10594-10603 VBN denotes increased
T6004 10604-10605 -LRB- denotes (
T6005 10605-10612 NNS denotes Figures
T6006 10613-10615 NN denotes 2B
T6007 10616-10619 CC denotes and
T6008 10620-10622 NN denotes 2C
T6009 10622-10623 -RRB- denotes )
T6010 10623-10624 . denotes .
T6011 10625-10629 RB denotes Thus
T6012 10629-10630 , denotes ,
T6013 10631-10633 IN denotes in
T6014 10634-10642 NN denotes contrast
T6015 10643-10645 TO denotes to
T6016 10646-10650 WP denotes what
T6017 10651-10654 VBD denotes was
T6018 10655-10663 VBN denotes observed
T6019 10664-10669 IN denotes under
T6020 10670-10673 JJ denotes Th1
T6021 10674-10684 NNS denotes conditions
T6022 10684-10685 , denotes ,
T6023 10686-10691 JJ denotes IL-10
T6024 10692-10702 NN denotes expression
T6025 10703-10705 IN denotes by
T6026 10706-10709 JJ denotes Th2
T6027 10710-10715 NNS denotes cells
T6028 10716-10724 VBD denotes depended
T6029 10725-10727 IN denotes on
T6030 10728-10733 NNP denotes STAT6
T6031 10733-10734 , denotes ,
T6032 10735-10738 CC denotes but
T6033 10739-10742 RB denotes not
T6034 10743-10745 IN denotes on
T6035 10746-10751 NNP denotes STAT4
T6036 10751-10752 , denotes ,
T6037 10753-10762 VBG denotes signaling
T6038 10763-10764 -LRB- denotes (
T6039 10764-10771 NNS denotes Figures
T6040 10772-10774 NN denotes 2B
T6041 10775-10778 CC denotes and
T6042 10779-10781 NN denotes 2C
T6043 10781-10782 -RRB- denotes )
T6044 10782-10783 . denotes .
T6045 10784-10786 TO denotes To
T6046 10787-10798 VB denotes investigate
T6047 10799-10806 IN denotes whether
T6048 10807-10810 DT denotes the
T6049 10811-10820 NN denotes inability
T6050 10821-10823 IN denotes of
T6051 10824-10839 JJ denotes STAT4-deficient
T6052 10840-10841 NNP denotes T
T6053 10842-10847 NNS denotes cells
T6054 10848-10850 TO denotes to
T6055 10851-10858 VB denotes produce
T6056 10859-10864 NN denotes IL-10
T6057 10865-10870 MD denotes might
T6058 10871-10873 VB denotes be
T6059 10874-10877 JJ denotes due
T6060 10878-10880 TO denotes to
T6061 10881-10884 DT denotes the
T6062 10885-10892 NN denotes absence
T6063 10893-10895 IN denotes of
T6064 10896-10901 NNP denotes IFN-γ
T6065 10901-10902 , denotes ,
T6066 10903-10905 IN denotes as
T6067 10906-10915 VBN denotes suggested
T6068 10916-10922 IN denotes before
T6069 10923-10924 -LRB- denotes (
T6070 10924-10928 NNP denotes Shaw
T6071 10929-10931 FW denotes et
T6072 10932-10935 FW denotes al.
T6073 10935-10936 , denotes ,
T6074 10937-10941 CD denotes 2006
T6075 10941-10942 -RRB- denotes )
T6076 10942-10943 , denotes ,
T6077 10944-10946 PRP denotes we
T6078 10947-10961 VBD denotes differentiated
T6079 10962-10966 NNP denotes DO11
T6080 10966-10969 CD denotes .10
T6081 10970-10972 CC denotes or
T6082 10973-10977 CD denotes DO11
T6083 10977-10980 CD denotes .10
T6084 10981-10996 JJ denotes IFN-γ-deficient
T6085 10997-11002 JJ denotes naive
T6086 11003-11006 NNP denotes CD4
T6087 11006-11007 CD denotes +
T6088 11008-11009 NNP denotes T
T6089 11010-11015 NNS denotes cells
T6090 11016-11018 IN denotes in
T6091 11019-11022 DT denotes the
T6092 11023-11031 NN denotes presence
T6093 11032-11034 IN denotes of
T6094 11035-11040 NN denotes IL-12
T6095 11041-11044 CC denotes and
T6096 11045-11055 VBG denotes increasing
T6097 11056-11061 NNS denotes doses
T6098 11062-11064 IN denotes of
T6099 11065-11068 NNP denotes OVA
T6100 11068-11069 . denotes .
T6101 11070-11073 DT denotes The
T6102 11074-11083 NN denotes secretion
T6103 11084-11086 IN denotes of
T6104 11087-11092 NNP denotes IL-10
T6105 11093-11095 IN denotes as
T6106 11096-11103 VBN denotes induced
T6107 11104-11106 IN denotes by
T6108 11107-11111 JJ denotes high
T6109 11112-11119 NN denotes antigen
T6110 11120-11124 NN denotes dose
T6111 11124-11125 , denotes ,
T6112 11126-11129 CC denotes and
T6113 11130-11135 NNP denotes IL-12
T6114 11136-11139 VBD denotes was
T6115 11140-11143 RB denotes not
T6116 11144-11152 VBN denotes affected
T6117 11153-11155 IN denotes by
T6118 11156-11158 DT denotes an
T6119 11159-11166 NN denotes absence
T6120 11167-11169 IN denotes of
T6121 11170-11175 NNP denotes IFN-γ
T6122 11176-11177 -LRB- denotes (
T6123 11177-11183 NNP denotes Figure
T6124 11184-11186 NNP denotes 2D
T6125 11186-11187 -RRB- denotes )
T6126 11187-11188 , denotes ,
T6127 11189-11196 VBG denotes showing
T6128 11197-11201 IN denotes that
T6129 11202-11205 DT denotes the
T6130 11206-11216 NN denotes expression
T6131 11217-11219 IN denotes of
T6132 11220-11225 NN denotes IL-10
T6133 11226-11228 IN denotes by
T6134 11229-11232 JJ denotes Th1
T6135 11233-11238 NNS denotes cells
T6136 11239-11241 VBZ denotes is
T6137 11242-11253 JJ denotes independent
T6138 11254-11256 IN denotes of
T6139 11257-11262 NNP denotes IFN-γ
T6140 11262-11263 . denotes .
T6141 11264-11266 IN denotes In
T6142 11267-11270 DT denotes the
T6143 11271-11278 NN denotes absence
T6144 11279-11281 IN denotes of
T6145 11282-11287 NNP denotes IFN-γ
T6146 11287-11288 , denotes ,
T6147 11289-11291 PRP denotes we
T6148 11292-11300 VBD denotes observed
T6149 11301-11303 DT denotes an
T6150 11304-11312 NN denotes increase
T6151 11313-11315 IN denotes in
T6152 11316-11319 DT denotes the
T6153 11320-11328 JJ denotes secreted
T6154 11329-11333 NN denotes IL-4
T6155 11334-11336 IN denotes as
T6156 11337-11345 VBN denotes expected
T6157 11346-11347 -LRB- denotes (
T6158 11347-11351 NNS denotes data
T6159 11352-11355 RB denotes not
T6160 11356-11361 VBN denotes shown
T6161 11361-11362 -RRB- denotes )
T6162 11362-11363 . denotes .
T6163 11364-11366 PRP denotes We
T6164 11367-11371 RB denotes also
T6165 11372-11378 VBD denotes tested
T6166 11379-11382 IN denotes for
T6167 11383-11386 DT denotes any
T6168 11387-11396 JJ denotes potential
T6169 11397-11401 NN denotes role
T6170 11402-11404 IN denotes of
T6171 11405-11409 NN denotes IL-4
T6172 11410-11412 IN denotes in
T6173 11413-11416 DT denotes the
T6174 11417-11428 NN denotes development
T6175 11429-11431 IN denotes of
T6176 11432-11435 JJ denotes Th1
T6177 11436-11441 NNS denotes cells
T6178 11442-11451 VBG denotes producing
T6179 11452-11457 NN denotes IL-10
T6180 11458-11460 IN denotes by
T6181 11461-11470 VBG denotes culturing
T6182 11471-11475 NNP denotes DO11
T6183 11475-11478 CD denotes .10
T6184 11479-11481 CC denotes or
T6185 11482-11486 CD denotes DO11
T6186 11486-11489 CD denotes .10
T6187 11490-11504 JJ denotes IL-4-deficient
T6188 11505-11510 JJ denotes naive
T6189 11511-11514 NNP denotes CD4
T6190 11514-11515 CD denotes +
T6191 11516-11517 NNP denotes T
T6192 11518-11523 NNS denotes cells
T6193 11524-11528 IN denotes with
T6194 11529-11534 NN denotes IL-12
T6195 11535-11538 CC denotes and
T6196 11539-11549 VBG denotes increasing
T6197 11550-11555 NNS denotes doses
T6198 11556-11558 IN denotes of
T6199 11559-11566 NN denotes antigen
T6200 11566-11567 . denotes .
T6201 11568-11570 IN denotes As
T6202 11571-11579 VBN denotes observed
T6203 11580-11582 IN denotes in
T6204 11583-11586 DT denotes the
T6205 11587-11594 NN denotes absence
T6206 11595-11597 IN denotes of
T6207 11598-11603 NNP denotes STAT6
T6208 11604-11605 -LRB- denotes (
T6209 11605-11611 NNP denotes Figure
T6210 11612-11614 NNP denotes 2A
T6211 11614-11615 -RRB- denotes )
T6212 11615-11616 , denotes ,
T6213 11617-11621 NN denotes IL-4
T6214 11622-11632 NN denotes deficiency
T6215 11633-11636 VBD denotes had
T6216 11637-11639 DT denotes no
T6217 11640-11646 NN denotes effect
T6218 11647-11649 IN denotes on
T6219 11650-11653 DT denotes the
T6220 11654-11665 NN denotes development
T6221 11666-11668 IN denotes of
T6222 11669-11672 JJ denotes Th1
T6223 11673-11678 NNS denotes cells
T6224 11679-11688 VBG denotes producing
T6225 11689-11694 NNP denotes IL-10
T6226 11695-11696 -LRB- denotes (
T6227 11696-11702 NNP denotes Figure
T6228 11703-11705 NNP denotes 2E
T6229 11705-11706 -RRB- denotes )
T6230 11706-11707 , denotes ,
T6231 11708-11711 CC denotes but
T6232 11712-11723 VBD denotes compromised
T6233 11724-11727 DT denotes the
T6234 11728-11739 NN denotes development
T6235 11740-11742 IN denotes of
T6236 11743-11746 JJ denotes Th2
T6237 11747-11752 NNS denotes cells
T6238 11753-11762 VBG denotes producing
T6239 11763-11768 NNP denotes IL-10
T6240 11769-11770 -LRB- denotes (
T6241 11770-11776 NNP denotes Figure
T6242 11777-11779 NNP denotes 2F
T6243 11779-11780 -RRB- denotes )
T6244 11780-11781 . denotes .
T6245 11782-11786 RB denotes Thus
T6246 11786-11787 , denotes ,
T6247 11788-11791 PRP$ denotes our
T6248 11792-11796 NNS denotes data
T6249 11797-11806 VBD denotes suggested
T6250 11807-11811 IN denotes that
T6251 11812-11817 JJ denotes IL-10
T6252 11818-11828 NN denotes production
T6253 11829-11831 IN denotes by
T6254 11832-11835 CD denotes Th1
T6255 11836-11838 CC denotes or
T6256 11839-11842 CD denotes Th2
T6257 11843-11848 NNS denotes cells
T6258 11849-11852 VBD denotes was
T6259 11853-11862 JJ denotes dependent
T6260 11863-11865 IN denotes on
T6261 11866-11869 DT denotes the
T6262 11870-11878 JJ denotes specific
T6263 11879-11888 VBG denotes signaling
T6264 11889-11897 NNS denotes pathways
T6265 11898-11906 VBN denotes required
T6266 11907-11910 IN denotes for
T6267 11911-11916 PRP$ denotes their
T6268 11917-11932 NN denotes differentiation
T6269 11932-11933 , denotes ,
T6270 11934-11939 VBN denotes given
T6271 11940-11944 IN denotes that
T6272 11945-11950 NNP denotes STAT4
T6273 11951-11953 VBZ denotes is
T6274 11954-11962 VBN denotes required
T6275 11963-11966 IN denotes for
T6276 11967-11970 DT denotes the
T6277 11971-11980 NN denotes induction
T6278 11981-11983 IN denotes of
T6279 11984-11989 JJ denotes IL-10
T6280 11990-12000 NN denotes production
T6281 12001-12003 IN denotes by
T6282 12004-12007 JJ denotes Th1
T6283 12008-12013 NNS denotes cells
T6284 12014-12017 CC denotes and
T6285 12018-12023 NNP denotes STAT6
T6286 12024-12027 IN denotes for
T6287 12028-12031 NNP denotes Th2
T6288 12032-12037 NNS denotes cells
T6289 12037-12038 . denotes .
T7295 12040-12044 NNP denotes High
T7296 12045-12052 NNP denotes Antigen
T7297 12053-12058 NNPS denotes Doses
T7298 12059-12062 CC denotes and
T7299 12063-12068 NNP denotes STAT4
T7300 12069-12072 VBP denotes Are
T7301 12073-12081 VBN denotes Required
T7302 12082-12085 IN denotes for
T7303 12086-12089 DT denotes the
T7304 12090-12092 NNP denotes In
T7305 12093-12097 NNP denotes Vivo
T7306 12098-12108 NNP denotes Generation
T7307 12109-12111 IN denotes of
T7308 12112-12127 NNP denotes IL-10-Producing
T7309 12128-12131 NNP denotes Th1
T7310 12132-12137 NNP denotes Cells
T7311 12138-12140 TO denotes To
T7312 12141-12148 VB denotes address
T7313 12149-12152 DT denotes the
T7314 12153-12163 NNS denotes mechanisms
T7315 12164-12174 VBG denotes regulating
T7316 12175-12180 JJ denotes IL-10
T7317 12181-12191 NN denotes production
T7318 12192-12194 IN denotes by
T7319 12195-12198 JJ denotes Th1
T7320 12199-12204 NNS denotes cells
T7321 12205-12207 IN denotes in
T7322 12208-12212 NN denotes vivo
T7323 12212-12213 , denotes ,
T7324 12214-12216 PRP denotes we
T7325 12217-12228 VBD denotes transferred
T7326 12229-12233 NNP denotes DO11
T7327 12233-12236 CD denotes .10
T7328 12237-12242 NNS denotes cells
T7329 12243-12247 IN denotes into
T7330 12248-12254 NNP denotes BALB/c
T7331 12255-12264 JJ denotes recipient
T7332 12265-12269 NNS denotes mice
T7333 12270-12273 CC denotes and
T7334 12274-12283 VBD denotes immunized
T7335 12284-12287 DT denotes the
T7336 12288-12298 NNS denotes recipients
T7337 12299-12303 IN denotes with
T7338 12304-12308 RB denotes very
T7339 12309-12313 JJ denotes high
T7340 12314-12319 NNS denotes doses
T7341 12320-12322 IN denotes of
T7342 12323-12334 NN denotes OVA-protein
T7343 12335-12339 IN denotes with
T7344 12340-12342 CC denotes or
T7345 12343-12350 IN denotes without
T7346 12351-12356 VBN denotes added
T7347 12357-12374 NN denotes lipopolysacharide
T7348 12375-12376 -LRB- denotes (
T7349 12376-12379 NNP denotes LPS
T7350 12379-12380 -RRB- denotes )
T7351 12380-12381 . denotes .
T7352 12382-12383 NNP denotes T
T7353 12384-12389 NNS denotes cells
T7354 12390-12394 VBD denotes were
T7355 12395-12404 VBN denotes recovered
T7356 12405-12409 IN denotes from
T7357 12410-12413 DT denotes the
T7358 12414-12422 JJ denotes inguinal
T7359 12423-12428 NN denotes lymph
T7360 12429-12434 VBZ denotes nodes
T7361 12435-12436 CD denotes 3
T7362 12437-12441 NNS denotes days
T7363 12442-12447 IN denotes after
T7364 12448-12455 VBG denotes priming
T7365 12456-12459 CC denotes and
T7366 12460-12472 VBN denotes restimulated
T7367 12473-12475 IN denotes in
T7368 12476-12481 NN denotes vitro
T7369 12482-12486 IN denotes with
T7370 12487-12490 NNP denotes OVA
T7371 12491-12498 NN denotes peptide
T7372 12499-12502 IN denotes for
T7373 12503-12505 CD denotes 48
T7374 12506-12508 NN denotes hr
T7375 12508-12509 . denotes .
T7376 12510-12514 DT denotes This
T7377 12515-12517 IN denotes in
T7378 12518-12522 NN denotes vivo
T7379 12523-12535 NN denotes immunization
T7380 12536-12543 VBD denotes induced
T7381 12544-12549 NNP denotes IL-10
T7382 12550-12553 CC denotes and
T7383 12554-12559 JJ denotes IFN-γ
T7384 12560-12570 NN denotes production
T7385 12570-12571 , denotes ,
T7386 12572-12575 CC denotes and
T7387 12576-12579 DT denotes the
T7388 12580-12586 NN denotes amount
T7389 12587-12589 IN denotes of
T7390 12590-12595 JJ denotes IL-10
T7391 12596-12606 NN denotes production
T7392 12607-12610 VBD denotes was
T7393 12611-12619 VBN denotes enhanced
T7394 12620-12622 IN denotes by
T7395 12623-12631 NN denotes addition
T7396 12632-12634 IN denotes of
T7397 12635-12638 NNP denotes LPS
T7398 12639-12641 IN denotes in
T7399 12642-12645 DT denotes the
T7400 12646-12658 NN denotes immunization
T7401 12659-12660 -LRB- denotes (
T7402 12660-12666 NN denotes Figure
T7403 12667-12669 NN denotes 3A
T7404 12669-12670 -RRB- denotes )
T7405 12671-12674 CC denotes and
T7406 12675-12679 IN denotes with
T7407 12680-12686 JJR denotes higher
T7408 12687-12692 NNS denotes doses
T7409 12693-12695 IN denotes of
T7410 12696-12699 NNP denotes OVA
T7411 12700-12701 -LRB- denotes (
T7412 12701-12702 CD denotes 3
T7413 12703-12705 NNP denotes μM
T7414 12706-12712 CC denotes versus
T7415 12713-12714 CD denotes 1
T7416 12715-12717 NNP denotes μM
T7417 12717-12718 , denotes ,
T7418 12719-12723 NNS denotes data
T7419 12724-12727 RB denotes not
T7420 12728-12733 VBN denotes shown
T7421 12733-12734 -RRB- denotes )
T7422 12734-12735 . denotes .
T7423 12736-12738 TO denotes To
T7424 12739-12743 VB denotes test
T7425 12744-12747 DT denotes the
T7426 12748-12752 NN denotes role
T7427 12753-12755 IN denotes of
T7428 12756-12761 NNP denotes STAT4
T7429 12762-12765 CC denotes and
T7430 12766-12771 NNP denotes STAT6
T7431 12772-12781 VBG denotes signaling
T7432 12782-12784 IN denotes in
T7433 12785-12788 DT denotes the
T7434 12789-12791 IN denotes in
T7435 12792-12796 NN denotes vivo
T7436 12797-12808 NN denotes development
T7437 12809-12811 IN denotes of
T7438 12812-12827 JJ denotes IL-10-producing
T7439 12828-12831 JJ denotes Th1
T7440 12832-12837 NNS denotes cells
T7441 12837-12838 , denotes ,
T7442 12839-12841 PRP denotes we
T7443 12842-12853 VBD denotes transferred
T7444 12854-12859 NNP denotes STAT4
T7445 12859-12860 : denotes -
T7446 12861-12863 CC denotes or
T7447 12864-12879 JJ denotes STAT6-deficient
T7448 12880-12882 CC denotes or
T7449 12883-12885 NNP denotes WT
T7450 12886-12890 NNP denotes DO11
T7451 12890-12893 CD denotes .10
T7452 12894-12899 NNS denotes cells
T7453 12900-12904 IN denotes into
T7454 12905-12914 JJ denotes recipient
T7455 12915-12921 NNP denotes BALB/c
T7456 12922-12926 NNS denotes mice
T7457 12927-12930 CC denotes and
T7458 12931-12940 VBN denotes immunized
T7459 12941-12945 IN denotes with
T7460 12946-12957 JJ denotes OVA-protein
T7461 12958-12962 CC denotes plus
T7462 12963-12966 NNP denotes LPS
T7463 12967-12969 IN denotes as
T7464 12970-12976 RB denotes before
T7465 12976-12977 . denotes .
T7466 12978-12980 IN denotes In
T7467 12981-12985 NN denotes vivo
T7468 12986-12996 NN denotes expression
T7469 12997-12999 IN denotes of
T7470 13000-13004 DT denotes both
T7471 13005-13010 NNP denotes IL-10
T7472 13011-13014 CC denotes and
T7473 13015-13020 NNP denotes IFN-γ
T7474 13021-13024 VBD denotes was
T7475 13025-13033 RB denotes markedly
T7476 13034-13041 VBN denotes reduced
T7477 13042-13045 CC denotes but
T7478 13046-13049 RB denotes not
T7479 13050-13060 RB denotes completely
T7480 13061-13070 VBN denotes abrogated
T7481 13071-13073 IN denotes in
T7482 13074-13077 DT denotes the
T7483 13078-13085 NN denotes absence
T7484 13086-13088 IN denotes of
T7485 13089-13094 CD denotes STAT4
T7486 13095-13104 VBG denotes signaling
T7487 13105-13106 -LRB- denotes (
T7488 13106-13113 NNS denotes Figures
T7489 13114-13116 NNP denotes 3B
T7490 13117-13120 CC denotes and
T7491 13121-13123 NNP denotes 3C
T7492 13123-13124 -RRB- denotes )
T7493 13124-13125 , denotes ,
T7494 13126-13136 VBG denotes suggesting
T7495 13137-13140 DT denotes the
T7496 13141-13150 NN denotes existence
T7497 13151-13153 IN denotes of
T7498 13154-13166 JJ denotes compensatory
T7499 13167-13177 NNS denotes mechanisms
T7500 13178-13182 WDT denotes that
T7501 13183-13187 VBD denotes were
T7502 13188-13194 JJ denotes absent
T7503 13195-13197 IN denotes in
T7504 13198-13201 DT denotes the
T7505 13202-13204 IN denotes in
T7506 13205-13210 NN denotes vitro
T7507 13211-13217 NN denotes system
T7508 13217-13218 . denotes .
T7509 13219-13228 VBG denotes Signaling
T7510 13229-13236 IN denotes through
T7511 13237-13242 NNP denotes STAT6
T7512 13243-13246 VBD denotes had
T7513 13247-13249 DT denotes no
T7514 13250-13256 NN denotes effect
T7515 13257-13259 IN denotes on
T7516 13260-13265 NN denotes IL-10
T7517 13266-13276 NN denotes production
T7518 13277-13279 IN denotes by
T7519 13280-13283 JJ denotes Th1
T7520 13284-13289 NNS denotes cells
T7521 13290-13292 IN denotes as
T7522 13293-13298 VBN denotes shown
T7523 13299-13301 IN denotes by
T7524 13302-13315 JJ denotes intracellular
T7525 13316-13324 NN denotes cytokine
T7526 13325-13333 NN denotes staining
T7527 13334-13335 -LRB- denotes (
T7528 13335-13338 NNP denotes ICS
T7529 13338-13339 -RRB- denotes )
T7530 13340-13343 CC denotes and
T7531 13344-13346 IN denotes by
T7532 13347-13358 NN denotes immunoassay
T7533 13359-13361 IN denotes in
T7534 13362-13377 JJ denotes STAT6-deficient
T7535 13378-13379 NNP denotes T
T7536 13380-13385 NNS denotes cells
T7537 13386-13387 -LRB- denotes (
T7538 13387-13394 NNS denotes Figures
T7539 13395-13397 NNP denotes 3B
T7540 13398-13401 CC denotes and
T7541 13402-13404 NNP denotes 3C
T7542 13404-13405 -RRB- denotes )
T7543 13405-13406 . denotes .
T8364 13408-13413 NNP denotes IL-10
T8365 13414-13424 NNP denotes Production
T8366 13425-13427 VBZ denotes Is
T8367 13428-13438 VBN denotes Maintained
T8368 13439-13441 IN denotes by
T8369 13442-13446 NNP denotes High
T8370 13447-13450 NNP denotes TCR
T8371 13451-13457 NNP denotes Signal
T8372 13458-13466 NNP denotes Strength
T8373 13467-13470 CC denotes and
T8374 13471-13476 NNP denotes IL-12
T8375 13477-13479 PRP denotes We
T8376 13480-13484 JJ denotes next
T8377 13485-13497 VBD denotes investigated
T8378 13498-13505 IN denotes whether
T8379 13506-13514 VBN denotes repeated
T8380 13515-13521 JJ denotes strong
T8381 13522-13525 NNP denotes TCR
T8382 13526-13536 NN denotes activation
T8383 13537-13539 VBZ denotes is
T8384 13540-13541 DT denotes a
T8385 13542-13554 JJ denotes compensatory
T8386 13555-13561 NN denotes signal
T8387 13562-13565 IN denotes for
T8388 13566-13579 JJ denotes IL-12-induced
T8389 13580-13585 CD denotes STAT4
T8390 13586-13595 VBG denotes signaling
T8391 13596-13598 IN denotes in
T8392 13599-13602 DT denotes the
T8393 13603-13612 NN denotes induction
T8394 13613-13615 IN denotes of
T8395 13616-13621 NNP denotes IL-10
T8396 13622-13624 IN denotes in
T8397 13625-13628 NNP denotes Th1
T8398 13629-13634 NNS denotes cells
T8399 13634-13635 . denotes .
T8400 13636-13639 IN denotes For
T8401 13640-13644 DT denotes this
T8402 13644-13645 , denotes ,
T8403 13646-13649 NNP denotes CD4
T8404 13649-13650 NNP denotes +
T8405 13651-13652 NNP denotes T
T8406 13653-13658 NNS denotes cells
T8407 13659-13663 VBD denotes were
T8408 13664-13678 VBN denotes differentiated
T8409 13679-13682 IN denotes for
T8410 13683-13684 CD denotes 2
T8411 13685-13696 JJ denotes consecutive
T8412 13697-13702 NNS denotes weeks
T8413 13703-13707 IN denotes with
T8414 13708-13712 JJ denotes high
T8415 13713-13720 NN denotes antigen
T8416 13721-13726 NNS denotes doses
T8417 13727-13729 IN denotes in
T8418 13730-13733 DT denotes the
T8419 13734-13742 NN denotes presence
T8420 13743-13745 CC denotes or
T8421 13746-13753 NN denotes absence
T8422 13754-13756 IN denotes of
T8423 13757-13762 NN denotes IL-12
T8424 13763-13773 IN denotes throughout
T8425 13774-13775 -LRB- denotes (
T8426 13775-13782 NNS denotes Figures
T8427 13783-13785 VBP denotes 4A
T8428 13786-13788 VBN denotes 4D
T8429 13788-13789 -RRB- denotes )
T8430 13789-13790 . denotes .
T8431 13791-13795 NNP denotes High
T8432 13796-13803 NN denotes antigen
T8433 13804-13808 NN denotes dose
T8434 13809-13812 CC denotes and
T8435 13813-13818 NN denotes IL-12
T8436 13819-13829 VBD denotes cooperated
T8437 13830-13832 TO denotes to
T8438 13833-13839 VB denotes induce
T8439 13840-13847 JJ denotes maximal
T8440 13848-13853 NN denotes IL-10
T8441 13854-13864 NN denotes production
T8442 13865-13866 -LRB- denotes (
T8443 13866-13873 NNS denotes Figures
T8444 13874-13876 NN denotes 4A
T8445 13877-13880 CC denotes and
T8446 13881-13883 NN denotes 4B
T8447 13883-13884 -RRB- denotes )
T8448 13884-13885 , denotes ,
T8449 13886-13891 VBN denotes given
T8450 13892-13896 IN denotes that
T8451 13897-13901 DT denotes this
T8452 13902-13913 NN denotes combination
T8453 13914-13922 VBD denotes resulted
T8454 13923-13925 IN denotes in
T8455 13926-13929 DT denotes the
T8456 13930-13937 JJS denotes highest
T8457 13938-13945 NNS denotes numbers
T8458 13946-13948 IN denotes of
T8459 13949-13964 JJ denotes IL-10-producing
T8460 13965-13968 JJ denotes Th1
T8461 13969-13974 NNS denotes cells
T8462 13974-13975 . denotes .
T8463 13976-13984 VBN denotes Repeated
T8464 13985-13989 JJ denotes high
T8465 13990-13997 NN denotes antigen
T8466 13998-14002 NN denotes dose
T8467 14003-14014 NN denotes stimulation
T8468 14015-14017 IN denotes in
T8469 14018-14021 DT denotes the
T8470 14022-14029 NN denotes absence
T8471 14030-14032 IN denotes of
T8472 14033-14044 RB denotes exogenously
T8473 14045-14050 VBN denotes added
T8474 14051-14056 NN denotes IL-12
T8475 14057-14065 VBD denotes resulted
T8476 14066-14068 IN denotes in
T8477 14069-14072 DT denotes the
T8478 14073-14083 NN denotes production
T8479 14084-14086 IN denotes of
T8480 14087-14092 NN denotes IL-10
T8481 14093-14095 IN denotes by
T8482 14096-14099 JJ denotes Th1
T8483 14100-14105 NNS denotes cells
T8484 14105-14106 , denotes ,
T8485 14107-14117 VBG denotes suggesting
T8486 14118-14122 IN denotes that
T8487 14123-14131 VBN denotes repeated
T8488 14132-14138 JJ denotes strong
T8489 14139-14142 NNP denotes TCR
T8490 14143-14153 VBG denotes triggering
T8491 14154-14157 MD denotes may
T8492 14158-14166 VB denotes overcome
T8493 14167-14170 DT denotes the
T8494 14171-14175 NN denotes need
T8495 14176-14179 IN denotes for
T8496 14180-14185 NNP denotes IL-12
T8497 14186-14189 IN denotes for
T8498 14190-14195 NNP denotes IL-10
T8499 14196-14205 NN denotes induction
T8500 14206-14207 -LRB- denotes (
T8501 14207-14214 NNS denotes Figures
T8502 14215-14217 NNP denotes 4C
T8503 14218-14221 CC denotes and
T8504 14222-14224 NNP denotes 4D
T8505 14224-14225 -RRB- denotes )
T8506 14225-14226 . denotes .
T8507 14227-14234 RB denotes However
T8508 14234-14235 , denotes ,
T8509 14236-14241 JJ denotes IL-10
T8510 14242-14251 NN denotes induction
T8511 14252-14257 IN denotes under
T8512 14258-14263 DT denotes these
T8513 14264-14274 NNS denotes conditions
T8514 14275-14278 VBD denotes was
T8515 14279-14288 VBN denotes abrogated
T8516 14289-14293 WRB denotes when
T8517 14294-14312 JJ denotes IL-12p40-deficient
T8518 14313-14316 NNS denotes DCs
T8519 14317-14321 VBD denotes were
T8520 14322-14326 VBN denotes used
T8521 14327-14329 IN denotes as
T8522 14330-14334 NNS denotes APCs
T8523 14335-14336 -LRB- denotes (
T8524 14336-14342 NN denotes Figure
T8525 14343-14345 CD denotes 4E
T8526 14345-14346 -RRB- denotes )
T8527 14346-14347 . denotes .
T8528 14348-14352 RB denotes Thus
T8529 14352-14353 , denotes ,
T8530 14354-14359 NN denotes IL-12
T8531 14360-14362 VBZ denotes is
T8532 14363-14372 JJ denotes essential
T8533 14373-14379 IN denotes during
T8534 14380-14384 DT denotes both
T8535 14385-14392 JJ denotes primary
T8536 14393-14396 CC denotes and
T8537 14397-14406 JJ denotes secondary
T8538 14407-14416 JJ denotes antigenic
T8539 14417-14428 NN denotes stimulation
T8540 14429-14432 IN denotes for
T8541 14433-14443 NN denotes production
T8542 14444-14446 IN denotes of
T8543 14447-14452 NN denotes IL-10
T8544 14453-14455 IN denotes by
T8545 14456-14459 JJ denotes Th1
T8546 14460-14465 NNS denotes cells
T8547 14465-14466 . denotes .
T8548 14467-14469 TO denotes To
T8549 14470-14479 VB denotes determine
T8550 14480-14483 DT denotes the
T8551 14484-14496 NNS denotes requirements
T8552 14497-14500 IN denotes for
T8553 14501-14510 NN denotes stability
T8554 14511-14513 IN denotes of
T8555 14514-14517 DT denotes the
T8556 14518-14533 JJ denotes IL-10-producing
T8557 14534-14537 JJ denotes Th1
T8558 14538-14543 NNS denotes cells
T8559 14543-14544 , denotes ,
T8560 14545-14547 PRP denotes we
T8561 14548-14562 VBD denotes differentiated
T8562 14563-14566 NNP denotes CD4
T8563 14566-14567 NNP denotes +
T8564 14568-14569 NNP denotes T
T8565 14570-14575 NNS denotes cells
T8566 14576-14579 IN denotes for
T8567 14580-14581 CD denotes 1
T8568 14582-14586 NN denotes week
T8569 14587-14591 IN denotes with
T8570 14592-14596 JJ denotes high
T8571 14597-14604 NN denotes antigen
T8572 14605-14610 NNS denotes doses
T8573 14611-14615 IN denotes with
T8574 14616-14618 CC denotes or
T8575 14619-14626 IN denotes without
T8576 14627-14632 NNP denotes IL-12
T8577 14633-14634 -LRB- denotes (
T8578 14634-14641 NNS denotes Figures
T8579 14642-14644 NN denotes 4A
T8580 14645-14648 CC denotes and
T8581 14649-14651 NN denotes 4C
T8582 14651-14652 -RRB- denotes )
T8583 14652-14653 , denotes ,
T8584 14654-14660 VBD denotes washed
T8585 14661-14665 PRP denotes them
T8586 14665-14666 , denotes ,
T8587 14667-14670 CC denotes and
T8588 14671-14675 RB denotes then
T8589 14676-14688 VBD denotes restimulated
T8590 14689-14693 PRP denotes them
T8591 14694-14697 IN denotes for
T8592 14698-14700 DT denotes an
T8593 14701-14711 JJ denotes additional
T8594 14712-14716 NN denotes week
T8595 14717-14721 IN denotes with
T8596 14722-14723 DT denotes a
T8597 14724-14727 JJ denotes low
T8598 14728-14735 NN denotes antigen
T8599 14736-14740 NN denotes dose
T8600 14740-14741 , denotes ,
T8601 14742-14744 IN denotes in
T8602 14745-14748 DT denotes the
T8603 14749-14756 NN denotes absence
T8604 14757-14759 CC denotes or
T8605 14760-14768 NN denotes presence
T8606 14769-14771 IN denotes of
T8607 14772-14777 NNP denotes IL-12
T8608 14778-14779 -LRB- denotes (
T8609 14779-14785 NNP denotes Figure
T8610 14786-14788 NNP denotes 4F
T8611 14788-14789 -RRB- denotes )
T8612 14789-14790 . denotes .
T8613 14791-14794 CD denotes Th1
T8614 14795-14800 NNS denotes cells
T8615 14801-14808 VBD denotes induced
T8616 14809-14811 IN denotes in
T8617 14812-14815 DT denotes the
T8618 14816-14821 JJ denotes first
T8619 14822-14826 NN denotes week
T8620 14827-14829 TO denotes to
T8621 14830-14837 VB denotes produce
T8622 14838-14843 NN denotes IL-10
T8623 14844-14846 IN denotes by
T8624 14847-14854 NN denotes culture
T8625 14855-14859 IN denotes with
T8626 14860-14864 JJ denotes high
T8627 14865-14872 NN denotes antigen
T8628 14873-14878 NNS denotes doses
T8629 14879-14882 CC denotes and
T8630 14883-14888 NN denotes IL-12
T8631 14889-14893 VBD denotes lost
T8632 14894-14899 PRP$ denotes their
T8633 14900-14907 NN denotes ability
T8634 14908-14910 TO denotes to
T8635 14911-14918 VB denotes express
T8636 14919-14924 NN denotes IL-10
T8637 14925-14929 WRB denotes when
T8638 14930-14940 VBN denotes recultured
T8639 14941-14945 IN denotes with
T8640 14946-14949 JJ denotes low
T8641 14950-14955 NNS denotes doses
T8642 14956-14958 IN denotes of
T8643 14959-14962 NNP denotes OVA
T8644 14962-14963 , denotes ,
T8645 14964-14969 WDT denotes which
T8646 14970-14975 MD denotes could
T8647 14976-14978 VB denotes be
T8648 14979-14990 VBN denotes compensated
T8649 14991-14994 IN denotes for
T8650 14994-14995 , denotes ,
T8651 14996-14998 TO denotes to
T8652 14999-15003 DT denotes some
T8653 15004-15010 NN denotes extent
T8654 15010-15011 , denotes ,
T8655 15012-15014 IN denotes by
T8656 15015-15023 NN denotes addition
T8657 15024-15026 IN denotes of
T8658 15027-15032 NN denotes IL-12
T8659 15033-15035 TO denotes to
T8660 15036-15039 DT denotes the
T8661 15040-15049 JJ denotes secondary
T8662 15050-15058 NNS denotes cultures
T8663 15059-15060 -LRB- denotes (
T8664 15060-15066 NN denotes Figure
T8665 15067-15069 CD denotes 4F
T8666 15069-15070 -RRB- denotes )
T8667 15070-15071 , denotes ,
T8668 15072-15077 RB denotes again
T8669 15078-15088 VBG denotes suggesting
T8670 15089-15093 IN denotes that
T8671 15094-15101 NN denotes antigen
T8672 15102-15106 NN denotes dose
T8673 15107-15110 CC denotes and
T8674 15111-15116 NN denotes IL-12
T8675 15117-15124 NNS denotes signals
T8676 15125-15134 VBP denotes cooperate
T8677 15135-15138 IN denotes for
T8678 15139-15142 DT denotes the
T8679 15143-15152 NN denotes induction
T8680 15153-15155 IN denotes of
T8681 15156-15161 NN denotes IL-10
T8682 15161-15162 . denotes .
T8683 15163-15170 RB denotes Finally
T8684 15170-15171 , denotes ,
T8685 15172-15176 NNP denotes DO11
T8686 15176-15179 CD denotes .10
T8687 15180-15183 NNP denotes CD4
T8688 15183-15184 NN denotes +
T8689 15185-15190 NNS denotes cells
T8690 15191-15195 WDT denotes that
T8691 15196-15200 VBD denotes were
T8692 15201-15208 VBN denotes exposed
T8693 15209-15211 TO denotes to
T8694 15212-15215 JJ denotes low
T8695 15216-15221 NNS denotes doses
T8696 15222-15224 IN denotes of
T8697 15225-15232 NN denotes antigen
T8698 15233-15236 CC denotes and
T8699 15237-15242 NN denotes IL-12
T8700 15243-15249 IN denotes during
T8701 15250-15253 DT denotes the
T8702 15254-15261 JJ denotes primary
T8703 15262-15277 NN denotes differentiation
T8704 15278-15283 NN denotes phase
T8705 15284-15292 VBD denotes produced
T8706 15293-15297 JJ denotes high
T8707 15298-15305 NNS denotes amounts
T8708 15306-15308 IN denotes of
T8709 15309-15314 JJ denotes IFN-γ
T8710 15315-15318 CC denotes but
T8711 15319-15325 JJ denotes little
T8712 15326-15331 NN denotes IL-10
T8713 15331-15332 , denotes ,
T8714 15333-15336 CC denotes but
T8715 15337-15341 PRP denotes they
T8716 15342-15347 MD denotes could
T8717 15348-15350 VB denotes be
T8718 15351-15358 VBN denotes induced
T8719 15359-15361 TO denotes to
T8720 15362-15369 VB denotes produce
T8721 15370-15375 NN denotes IL-10
T8722 15376-15380 WRB denotes when
T8723 15381-15385 DT denotes both
T8724 15386-15390 JJ denotes high
T8725 15391-15398 NN denotes antigen
T8726 15399-15403 NN denotes dose
T8727 15404-15407 CC denotes and
T8728 15408-15413 NN denotes IL-12
T8729 15414-15418 VBD denotes were
T8730 15419-15426 JJ denotes present
T8731 15427-15433 IN denotes during
T8732 15434-15437 DT denotes the
T8733 15438-15444 NN denotes recall
T8734 15445-15450 NN denotes phase
T8735 15451-15452 -LRB- denotes (
T8736 15452-15458 NN denotes Figure
T8737 15459-15461 CD denotes S4
T8738 15461-15462 -RRB- denotes )
T8739 15462-15463 . denotes .
T8740 15464-15468 RB denotes Thus
T8741 15468-15469 , denotes ,
T8742 15470-15474 JJ denotes high
T8743 15475-15482 NN denotes antigen
T8744 15483-15487 NN denotes dose
T8745 15488-15491 CC denotes and
T8746 15492-15497 NN denotes IL-12
T8747 15498-15501 VBP denotes are
T8748 15502-15510 VBN denotes required
T8749 15511-15514 IN denotes for
T8750 15515-15525 VBG denotes sustaining
T8751 15526-15529 DT denotes the
T8752 15530-15539 NN denotes induction
T8753 15540-15542 IN denotes of
T8754 15543-15548 JJ denotes IL-10
T8755 15549-15559 NN denotes production
T8756 15560-15562 IN denotes by
T8757 15563-15566 JJ denotes Th1
T8758 15567-15572 NNS denotes cells
T8759 15572-15573 . denotes .
T9893 15575-15580 NNP denotes IL-10
T9894 15581-15591 NNP denotes Production
T9895 15592-15594 IN denotes by
T9896 15595-15598 NNP denotes Th1
T9897 15599-15604 NNP denotes Cells
T9898 15605-15613 VBZ denotes Requires
T9899 15614-15618 CD denotes ERK1
T9900 15619-15622 CC denotes and
T9901 15623-15627 CD denotes ERK2
T9902 15628-15638 NNP denotes Activation
T9903 15639-15642 PRP$ denotes Our
T9904 15643-15647 NNS denotes data
T9905 15648-15654 VBD denotes showed
T9906 15655-15659 IN denotes that
T9907 15660-15663 DT denotes the
T9908 15664-15675 NN denotes maintenance
T9909 15676-15678 IN denotes of
T9910 15679-15684 NNP denotes IL-10
T9911 15685-15694 NN denotes induction
T9912 15695-15697 IN denotes in
T9913 15698-15701 JJ denotes Th1
T9914 15702-15707 NNS denotes cells
T9915 15708-15716 VBN denotes required
T9916 15717-15728 NN denotes stimulation
T9917 15729-15733 IN denotes with
T9918 15734-15738 JJ denotes high
T9919 15739-15746 NN denotes antigen
T9920 15747-15751 NN denotes dose
T9921 15751-15752 , denotes ,
T9922 15753-15758 WDT denotes which
T9923 15759-15761 TO denotes to
T9924 15762-15766 DT denotes some
T9925 15767-15773 NN denotes extent
T9926 15774-15779 MD denotes could
T9927 15780-15782 VB denotes be
T9928 15783-15794 VBN denotes compensated
T9929 15795-15798 IN denotes for
T9930 15799-15801 IN denotes by
T9931 15802-15805 DT denotes the
T9932 15806-15814 NN denotes addition
T9933 15815-15817 IN denotes of
T9934 15818-15823 NN denotes IL-12
T9935 15823-15824 . denotes .
T9936 15825-15834 VBG denotes Signaling
T9937 15835-15842 IN denotes through
T9938 15843-15846 DT denotes the
T9939 15847-15850 NNP denotes TCR
T9940 15851-15855 IN denotes with
T9941 15856-15860 JJ denotes high
T9942 15861-15866 NNS denotes doses
T9943 15867-15869 IN denotes of
T9944 15870-15877 NN denotes antigen
T9945 15878-15885 VBD denotes induced
T9946 15886-15894 JJR denotes stronger
T9947 15895-15899 NNP denotes ERK1
T9948 15900-15903 CC denotes and
T9949 15904-15908 NNP denotes ERK2
T9950 15909-15919 NN denotes activation
T9951 15920-15924 IN denotes than
T9952 15925-15929 DT denotes that
T9953 15930-15937 VBN denotes induced
T9954 15938-15940 IN denotes by
T9955 15941-15944 JJ denotes low
T9956 15945-15952 NN denotes antigen
T9957 15953-15957 NN denotes dose
T9958 15957-15958 , denotes ,
T9959 15959-15962 RB denotes not
T9960 15963-15967 RB denotes only
T9961 15968-15970 IN denotes in
T9962 15971-15976 JJ denotes naive
T9963 15977-15980 NNP denotes CD4
T9964 15980-15981 CD denotes +
T9965 15982-15983 NNP denotes T
T9966 15984-15989 NNS denotes cells
T9967 15990-15991 -LRB- denotes (
T9968 15991-15995 NNS denotes data
T9969 15996-15999 RB denotes not
T9970 16000-16005 VBN denotes shown
T9971 16005-16006 -RRB- denotes )
T9972 16007-16009 IN denotes as
T9973 16010-16020 RB denotes previously
T9974 16021-16033 VBN denotes demonstrated
T9975 16034-16035 -LRB- denotes (
T9976 16035-16044 NNP denotes Jorritsma
T9977 16045-16047 FW denotes et
T9978 16048-16051 FW denotes al.
T9979 16051-16052 , denotes ,
T9980 16053-16057 CD denotes 2003
T9981 16057-16058 -RRB- denotes )
T9982 16059-16062 CC denotes but
T9983 16063-16067 RB denotes also
T9984 16068-16070 IN denotes in
T9985 16071-16074 CD denotes CD4
T9986 16074-16075 CD denotes +
T9987 16076-16077 NNP denotes T
T9988 16078-16083 NNS denotes cells
T9989 16084-16096 VBD denotes restimulated
T9990 16097-16101 IN denotes with
T9991 16102-16105 DT denotes the
T9992 16106-16110 JJ denotes same
T9993 16111-16115 JJ denotes high
T9994 16116-16119 CC denotes and
T9995 16120-16123 JJ denotes low
T9996 16124-16131 NN denotes antigen
T9997 16132-16137 NNS denotes doses
T9998 16138-16139 -LRB- denotes (
T9999 16139-16145 NN denotes Figure
T10000 16146-16148 NN denotes 5A
T10001 16148-16149 -RRB- denotes )
T10002 16149-16150 . denotes .
T10003 16151-16159 IN denotes Although
T10004 16160-16163 DT denotes the
T10005 16164-16172 JJ denotes apparent
T10006 16173-16177 NN denotes peak
T10007 16178-16181 CC denotes and
T10008 16182-16188 NN denotes amount
T10009 16189-16191 IN denotes of
T10010 16192-16196 CD denotes ERK1
T10011 16197-16200 CC denotes and
T10012 16201-16205 CD denotes ERK2
T10013 16206-16216 NN denotes activation
T10014 16217-16223 VBD denotes varied
T10015 16224-16232 RB denotes slightly
T10016 16233-16240 IN denotes between
T10017 16241-16252 NNS denotes experiments
T10018 16252-16253 , denotes ,
T10019 16254-16255 DT denotes a
T10020 16256-16266 JJ denotes consistent
T10021 16267-16274 NN denotes finding
T10022 16275-16278 VBD denotes was
T10023 16279-16283 DT denotes that
T10024 16284-16288 JJ denotes high
T10025 16289-16296 NN denotes antigen
T10026 16297-16301 NN denotes dose
T10027 16302-16316 VBD denotes differentiated
T10028 16317-16320 CD denotes Th1
T10029 16321-16326 NNS denotes cells
T10030 16327-16333 RB denotes always
T10031 16334-16340 VBD denotes showed
T10032 16341-16349 JJ denotes enhanced
T10033 16350-16353 CC denotes and
T10034 16354-16363 JJ denotes prolonged
T10035 16364-16368 CD denotes ERK1
T10036 16369-16372 CC denotes and
T10037 16373-16377 CD denotes ERK2
T10038 16378-16388 NN denotes activation
T10039 16389-16391 IN denotes in
T10040 16392-16395 DT denotes the
T10041 16396-16404 NN denotes presence
T10042 16405-16407 IN denotes of
T10043 16408-16413 NN denotes IL-12
T10044 16413-16414 , denotes ,
T10045 16415-16425 RB denotes regardless
T10046 16426-16428 IN denotes of
T10047 16429-16436 IN denotes whether
T10048 16437-16441 PRP denotes they
T10049 16442-16446 VBD denotes were
T10050 16447-16459 VBN denotes restimulated
T10051 16460-16464 IN denotes with
T10052 16465-16469 JJ denotes high
T10053 16470-16472 CC denotes or
T10054 16473-16476 JJ denotes low
T10055 16477-16484 NN denotes antigen
T10056 16485-16489 NN denotes dose
T10057 16490-16491 -LRB- denotes (
T10058 16491-16497 NN denotes Figure
T10059 16498-16500 NN denotes 5B
T10060 16500-16501 -RRB- denotes )
T10061 16501-16502 . denotes .
T10062 16503-16505 PRP denotes We
T10063 16506-16510 RB denotes then
T10064 16511-16523 VBD denotes investigated
T10065 16524-16531 IN denotes whether
T10066 16532-16536 NNP denotes ERK1
T10067 16537-16540 CC denotes and
T10068 16541-16545 NNP denotes ERK2
T10069 16546-16556 NN denotes activation
T10070 16557-16560 VBD denotes was
T10071 16561-16569 VBN denotes required
T10072 16570-16573 IN denotes for
T10073 16574-16577 DT denotes the
T10074 16578-16587 NN denotes induction
T10075 16588-16590 IN denotes of
T10076 16591-16596 NNP denotes IL-10
T10077 16597-16599 IN denotes in
T10078 16600-16603 NNP denotes Th1
T10079 16604-16609 NNS denotes cells
T10080 16610-16612 IN denotes by
T10081 16613-16618 VBG denotes using
T10082 16619-16624 NNP denotes U0126
T10083 16625-16626 -LRB- denotes (
T10084 16626-16632 NNP denotes Figure
T10085 16633-16635 NNP denotes 5C
T10086 16635-16636 -RRB- denotes )
T10087 16636-16637 , denotes ,
T10088 16638-16639 DT denotes a
T10089 16640-16648 NN denotes compound
T10090 16649-16653 WDT denotes that
T10091 16654-16660 VBZ denotes blocks
T10092 16661-16671 JJ denotes downstream
T10093 16672-16675 NNP denotes ERK
T10094 16676-16686 NN denotes activation
T10095 16686-16687 . denotes .
T10096 16688-16690 TO denotes To
T10097 16691-16697 VB denotes ensure
T10098 16698-16702 IN denotes that
T10099 16703-16707 RB denotes only
T10100 16708-16709 NNP denotes T
T10101 16710-16714 NN denotes cell
T10102 16715-16724 VBG denotes signaling
T10103 16725-16728 VBD denotes was
T10104 16729-16734 VBG denotes being
T10105 16735-16743 VBN denotes affected
T10106 16744-16746 IN denotes by
T10107 16747-16752 NNP denotes U0126
T10108 16752-16753 , denotes ,
T10109 16754-16756 PRP denotes we
T10110 16757-16761 VBD denotes used
T10111 16762-16764 DT denotes an
T10112 16765-16773 JJ denotes APC-free
T10113 16774-16780 NN denotes system
T10114 16781-16783 IN denotes in
T10115 16784-16789 WDT denotes which
T10116 16790-16793 DT denotes the
T10117 16794-16795 NNP denotes T
T10118 16796-16801 NNS denotes cells
T10119 16802-16806 VBD denotes were
T10120 16807-16821 VBN denotes differentiated
T10121 16822-16824 IN denotes in
T10122 16825-16828 DT denotes the
T10123 16829-16837 NN denotes presence
T10124 16838-16840 IN denotes of
T10125 16841-16851 VBG denotes increasing
T10126 16852-16857 NNS denotes doses
T10127 16858-16860 IN denotes of
T10128 16861-16869 JJ denotes anti-CD3
T10129 16870-16873 CC denotes and
T10130 16874-16875 DT denotes a
T10131 16876-16884 JJ denotes constant
T10132 16885-16891 NN denotes amount
T10133 16892-16894 IN denotes of
T10134 16895-16900 NN denotes IL-12
T10135 16900-16901 . denotes .
T10136 16902-16904 IN denotes As
T10137 16905-16907 IN denotes in
T10138 16908-16911 DT denotes the
T10139 16912-16922 JJ denotes APC-driven
T10140 16923-16931 NNS denotes cultures
T10141 16931-16932 , denotes ,
T10142 16933-16941 JJR denotes stronger
T10143 16942-16945 NNP denotes TCR
T10144 16946-16957 NN denotes stimulation
T10145 16958-16966 RB denotes together
T10146 16967-16971 IN denotes with
T10147 16972-16977 NNP denotes IL-12
T10148 16978-16981 VBD denotes led
T10149 16982-16984 TO denotes to
T10150 16985-16991 JJR denotes higher
T10151 16992-17003 NNS denotes percentages
T10152 17004-17006 IN denotes of
T10153 17007-17012 NNS denotes cells
T10154 17013-17022 VBG denotes producing
T10155 17023-17027 DT denotes both
T10156 17028-17033 NNP denotes IL-10
T10157 17034-17037 CC denotes and
T10158 17038-17043 NNP denotes IFN-γ
T10159 17044-17049 IN denotes after
T10160 17050-17051 CD denotes 1
T10161 17052-17056 NN denotes week
T10162 17057-17059 IN denotes of
T10163 17060-17067 NN denotes culture
T10164 17068-17069 -LRB- denotes (
T10165 17069-17075 NN denotes Figure
T10166 17076-17078 NN denotes 5C
T10167 17078-17079 -RRB- denotes )
T10168 17079-17080 . denotes .
T10169 17081-17089 NN denotes Addition
T10170 17090-17092 IN denotes of
T10171 17093-17098 CD denotes U0126
T10172 17099-17101 TO denotes to
T10173 17102-17105 DT denotes the
T10174 17106-17114 NNS denotes cultures
T10175 17115-17124 VBD denotes abrogated
T10176 17125-17128 DT denotes the
T10177 17129-17139 NN denotes production
T10178 17140-17142 IN denotes of
T10179 17143-17148 NN denotes IL-10
T10180 17149-17151 IN denotes at
T10181 17152-17155 DT denotes all
T10182 17156-17161 NNS denotes doses
T10183 17162-17164 IN denotes of
T10184 17165-17173 JJ denotes anti-CD3
T10185 17174-17175 -LRB- denotes (
T10186 17175-17181 NN denotes Figure
T10187 17182-17184 NN denotes 5C
T10188 17184-17185 -RRB- denotes )
T10189 17185-17186 . denotes .
T10190 17187-17194 IN denotes Because
T10191 17195-17200 NNP denotes U0126
T10192 17201-17209 VBZ denotes inhibits
T10193 17210-17213 DT denotes the
T10194 17214-17228 JJ denotes MEK5-catalyzed
T10195 17229-17239 NN denotes activation
T10196 17240-17242 IN denotes of
T10197 17243-17247 CD denotes ERK5
T10198 17247-17248 , denotes ,
T10199 17249-17251 RB denotes as
T10200 17252-17256 RB denotes well
T10201 17257-17259 IN denotes as
T10202 17260-17263 DT denotes the
T10203 17264-17268 NNP denotes MEK1
T10204 17268-17269 : denotes -
T10205 17270-17273 CC denotes and
T10206 17274-17288 JJ denotes MEK2-catalyzed
T10207 17289-17299 NN denotes activation
T10208 17300-17302 IN denotes of
T10209 17303-17307 CD denotes ERK1
T10210 17308-17311 CC denotes and
T10211 17312-17316 CD denotes ERK2
T10212 17317-17318 -LRB- denotes (
T10213 17318-17322 NNP denotes Bain
T10214 17323-17325 FW denotes et
T10215 17326-17329 FW denotes al.
T10216 17329-17330 , denotes ,
T10217 17331-17335 CD denotes 2007
T10218 17335-17336 : denotes ;
T10219 17337-17341 NNP denotes Mody
T10220 17342-17344 FW denotes et
T10221 17345-17348 FW denotes al.
T10222 17348-17349 , denotes ,
T10223 17350-17354 CD denotes 2001
T10224 17354-17355 -RRB- denotes )
T10225 17355-17356 , denotes ,
T10226 17357-17359 PRP denotes we
T10227 17360-17364 RB denotes also
T10228 17365-17369 VBD denotes used
T10229 17370-17373 DT denotes the
T10230 17374-17378 RBR denotes more
T10231 17379-17387 JJ denotes specific
T10232 17387-17388 , denotes ,
T10233 17389-17401 RB denotes structurally
T10234 17402-17411 JJ denotes unrelated
T10235 17412-17416 NNP denotes MEK1
T10236 17417-17420 CC denotes and
T10237 17421-17425 NNP denotes MEK2
T10238 17426-17435 NN denotes inhibitor
T10239 17436-17444 NNP denotes PD184352
T10240 17445-17447 IN denotes at
T10241 17448-17462 NNS denotes concentrations
T10242 17463-17465 IN denotes in
T10243 17466-17471 WDT denotes which
T10244 17472-17474 PRP denotes it
T10245 17475-17483 VBZ denotes inhibits
T10246 17484-17488 NNP denotes MEK1
T10247 17489-17492 CC denotes and
T10248 17493-17497 NNP denotes MEK2
T10249 17498-17501 CC denotes but
T10250 17502-17505 RB denotes not
T10251 17506-17510 NNP denotes MEK5
T10252 17511-17512 -LRB- denotes (
T10253 17512-17516 NNP denotes Bain
T10254 17517-17519 FW denotes et
T10255 17520-17523 FW denotes al.
T10256 17523-17524 , denotes ,
T10257 17525-17529 CD denotes 2007
T10258 17529-17530 : denotes ;
T10259 17531-17535 NNP denotes Mody
T10260 17536-17538 FW denotes et
T10261 17539-17542 FW denotes al.
T10262 17542-17543 , denotes ,
T10263 17544-17548 CD denotes 2001
T10264 17548-17549 -RRB- denotes )
T10265 17549-17550 . denotes .
T10266 17551-17559 CD denotes PD184352
T10267 17560-17566 VBD denotes caused
T10268 17567-17568 DT denotes a
T10269 17569-17576 JJ denotes similar
T10270 17577-17587 NN denotes inhibition
T10271 17588-17590 IN denotes of
T10272 17591-17596 JJ denotes IL-10
T10273 17597-17607 NN denotes production
T10274 17608-17610 IN denotes by
T10275 17611-17614 JJ denotes Th1
T10276 17615-17620 NNS denotes cells
T10277 17621-17623 IN denotes in
T10278 17624-17625 DT denotes a
T10279 17626-17640 JJ denotes dose-dependent
T10280 17641-17648 NN denotes fashion
T10281 17649-17650 -LRB- denotes (
T10282 17650-17656 NN denotes Figure
T10283 17657-17659 CD denotes 5D
T10284 17660-17663 CC denotes and
T10285 17664-17670 NNP denotes Figure
T10286 17671-17674 NNP denotes S5A
T10287 17674-17675 -RRB- denotes )
T10288 17675-17676 . denotes .
T10289 17677-17681 IN denotes Upon
T10290 17682-17690 NN denotes addition
T10291 17691-17693 IN denotes of
T10292 17694-17704 NNS denotes inhibitors
T10293 17705-17707 TO denotes to
T10294 17708-17713 JJ denotes other
T10295 17714-17723 VBG denotes signaling
T10296 17724-17732 NNS denotes pathways
T10297 17732-17733 , denotes ,
T10298 17734-17743 VBG denotes including
T10299 17744-17745 DT denotes a
T10300 17746-17749 JJ denotes p38
T10301 17750-17754 NNP denotes MAPK
T10302 17755-17764 NN denotes inhibitor
T10303 17764-17765 , denotes ,
T10304 17766-17774 NNP denotes SB203580
T10305 17774-17775 , denotes ,
T10306 17776-17778 CC denotes or
T10307 17779-17782 DT denotes the
T10308 17783-17788 NNP denotes GSK3β
T10309 17789-17798 NN denotes inhibitor
T10310 17798-17799 , denotes ,
T10311 17800-17807 NNP denotes CT99021
T10312 17808-17809 -LRB- denotes (
T10313 17809-17813 NNP denotes Bain
T10314 17814-17816 FW denotes et
T10315 17817-17820 FW denotes al.
T10316 17820-17821 , denotes ,
T10317 17822-17826 CD denotes 2007
T10318 17826-17827 -RRB- denotes )
T10319 17827-17828 , denotes ,
T10320 17829-17831 DT denotes no
T10321 17832-17838 NN denotes effect
T10322 17839-17841 IN denotes on
T10323 17842-17847 NN denotes IL-10
T10324 17848-17858 NN denotes production
T10325 17859-17862 VBD denotes was
T10326 17863-17871 VBN denotes observed
T10327 17872-17873 -LRB- denotes (
T10328 17873-17879 NN denotes Figure
T10329 17880-17883 CD denotes S5B
T10330 17883-17884 -RRB- denotes )
T10331 17884-17885 . denotes .
T10332 17886-17889 PRP$ denotes Our
T10333 17890-17894 NNS denotes data
T10334 17895-17899 RB denotes thus
T10335 17900-17909 VBD denotes suggested
T10336 17910-17914 IN denotes that
T10337 17915-17920 JJ denotes IL-10
T10338 17921-17931 NN denotes production
T10339 17932-17934 IN denotes by
T10340 17935-17938 JJ denotes Th1
T10341 17939-17944 NNS denotes cells
T10342 17945-17947 IN denotes in
T10343 17948-17956 NN denotes response
T10344 17957-17959 TO denotes to
T10345 17960-17964 JJ denotes high
T10346 17965-17972 NN denotes antigen
T10347 17973-17977 NN denotes dose
T10348 17978-17981 CC denotes and
T10349 17982-17987 NN denotes IL-12
T10350 17988-17996 VBZ denotes requires
T10351 17997-18001 CD denotes ERK1
T10352 18002-18005 CC denotes and
T10353 18006-18010 CD denotes ERK2
T10354 18011-18020 VBG denotes signaling
T10355 18020-18021 , denotes ,
T10356 18022-18025 CC denotes but
T10357 18026-18029 RB denotes not
T10358 18030-18033 DT denotes the
T10359 18034-18044 NN denotes activation
T10360 18045-18047 IN denotes of
T10361 18048-18051 DT denotes the
T10362 18052-18055 CD denotes p38
T10363 18056-18058 CC denotes or
T10364 18059-18062 DT denotes the
T10365 18063-18068 NNP denotes GSK3β
T10366 18069-18077 NNS denotes pathways
T10367 18077-18078 . denotes .
T11223 18080-18085 NNP denotes IL-10
T11224 18086-18096 NNP denotes Production
T11225 18097-18099 IN denotes by
T11226 18100-18103 NNP denotes Th2
T11227 18104-18107 CC denotes and
T11228 18108-18112 NNP denotes Th17
T11229 18113-18118 NNP denotes Cells
T11230 18119-18123 RB denotes Also
T11231 18124-18132 VBZ denotes Requires
T11232 18133-18137 CD denotes ERK1
T11233 18138-18141 CC denotes and
T11234 18142-18146 CD denotes ERK2
T11235 18147-18157 NNP denotes Activation
T11236 18158-18160 TO denotes To
T11237 18161-18168 VB denotes address
T11238 18169-18176 IN denotes whether
T11239 18177-18182 NN denotes IL-10
T11240 18183-18193 NN denotes production
T11241 18194-18196 IN denotes by
T11242 18197-18200 NNP denotes Th2
T11243 18201-18204 CC denotes and
T11244 18205-18209 NNP denotes Th17
T11245 18210-18215 NNS denotes cells
T11246 18216-18219 VBD denotes was
T11247 18220-18224 RB denotes also
T11248 18225-18234 JJ denotes dependent
T11249 18235-18237 IN denotes on
T11250 18238-18242 CD denotes ERK1
T11251 18243-18246 CC denotes and
T11252 18247-18251 CD denotes ERK2
T11253 18252-18262 NN denotes activation
T11254 18262-18263 , denotes ,
T11255 18264-18266 PRP denotes we
T11256 18267-18281 VBD denotes differentiated
T11257 18282-18287 DT denotes these
T11258 18288-18293 NNS denotes cells
T11259 18294-18298 IN denotes with
T11260 18299-18307 JJ denotes anti-CD3
T11261 18308-18311 CC denotes and
T11262 18312-18321 JJ denotes anti-CD28
T11263 18322-18324 IN denotes in
T11264 18325-18328 DT denotes the
T11265 18329-18336 NN denotes absence
T11266 18337-18339 IN denotes of
T11267 18340-18344 NNS denotes APCs
T11268 18345-18346 -LRB- denotes (
T11269 18346-18355 NN denotes Shoemaker
T11270 18356-18358 FW denotes et
T11271 18359-18362 FW denotes al.
T11272 18362-18363 , denotes ,
T11273 18364-18368 CD denotes 2006
T11274 18368-18369 : denotes ;
T11275 18370-18378 NNP denotes Veldhoen
T11276 18379-18381 FW denotes et
T11277 18382-18385 FW denotes al.
T11278 18385-18386 , denotes ,
T11279 18387-18391 CD denotes 2009
T11280 18391-18392 : denotes ;
T11281 18393-18401 NNP denotes Veldhoen
T11282 18402-18404 FW denotes et
T11283 18405-18408 FW denotes al.
T11284 18408-18409 , denotes ,
T11285 18410-18414 CD denotes 2006
T11286 18414-18415 -RRB- denotes )
T11287 18415-18416 , denotes ,
T11288 18417-18419 IN denotes in
T11289 18420-18423 DT denotes the
T11290 18424-18432 NN denotes presence
T11291 18433-18435 CC denotes or
T11292 18436-18443 NN denotes absence
T11293 18444-18446 IN denotes of
T11294 18447-18450 DT denotes the
T11295 18451-18454 NNP denotes MEK
T11296 18455-18464 NN denotes inhibitor
T11297 18465-18466 -LRB- denotes (
T11298 18466-18474 NNP denotes PD184352
T11299 18474-18475 -RRB- denotes )
T11300 18475-18476 . denotes .
T11301 18477-18479 PRP denotes We
T11302 18480-18486 VBD denotes showed
T11303 18487-18491 IN denotes that
T11304 18492-18496 CD denotes ERK1
T11305 18497-18500 CC denotes and
T11306 18501-18505 CD denotes ERK2
T11307 18506-18516 NN denotes activation
T11308 18517-18519 VBZ denotes is
T11309 18520-18521 DT denotes a
T11310 18522-18528 JJ denotes common
T11311 18529-18536 NN denotes pathway
T11312 18537-18545 VBN denotes required
T11313 18546-18549 IN denotes for
T11314 18550-18559 NN denotes induction
T11315 18560-18562 IN denotes of
T11316 18563-18568 NN denotes IL-10
T11317 18569-18571 IN denotes in
T11318 18572-18581 JJ denotes different
T11319 18582-18584 NN denotes Th
T11320 18585-18589 NN denotes cell
T11321 18590-18597 NNS denotes subsets
T11322 18598-18605 IN denotes because
T11323 18606-18611 JJ denotes IL-10
T11324 18612-18622 NN denotes production
T11325 18623-18625 IN denotes by
T11326 18626-18630 DT denotes both
T11327 18631-18634 NNP denotes Th2
T11328 18635-18638 CC denotes and
T11329 18639-18643 NNP denotes Th17
T11330 18644-18649 NNS denotes cells
T11331 18650-18653 VBD denotes was
T11332 18654-18662 RB denotes markedly
T11333 18663-18672 VBN denotes inhibited
T11334 18673-18675 IN denotes in
T11335 18676-18679 DT denotes the
T11336 18680-18688 NN denotes presence
T11337 18689-18691 IN denotes of
T11338 18692-18695 DT denotes the
T11339 18696-18699 NNP denotes MEK
T11340 18700-18709 NN denotes inhibitor
T11341 18710-18711 -LRB- denotes (
T11342 18711-18719 NNP denotes PD184352
T11343 18719-18720 -RRB- denotes )
T11344 18721-18722 -LRB- denotes (
T11345 18722-18728 NN denotes Figure
T11346 18729-18731 CD denotes 5D
T11347 18732-18735 CC denotes and
T11348 18736-18742 NNP denotes Figure
T11349 18743-18746 NNP denotes S5B
T11350 18746-18747 -RRB- denotes )
T11351 18747-18748 . denotes .
T11352 18749-18751 IN denotes In
T11353 18752-18760 NN denotes contrast
T11354 18760-18761 , denotes ,
T11355 18762-18772 NNS denotes inhibitors
T11356 18773-18775 IN denotes of
T11357 18776-18779 CD denotes p38
T11358 18780-18784 NNP denotes MAPK
T11359 18785-18787 CC denotes or
T11360 18788-18790 IN denotes of
T11361 18791-18797 JJ denotes GSK-3β
T11362 18798-18808 NN denotes activation
T11363 18809-18812 VBD denotes did
T11364 18813-18816 RB denotes not
T11365 18817-18823 VB denotes affect
T11366 18824-18827 DT denotes the
T11367 18828-18838 NN denotes expression
T11368 18839-18841 IN denotes of
T11369 18842-18847 NN denotes IL-10
T11370 18848-18850 IN denotes by
T11371 18851-18856 DT denotes these
T11372 18857-18864 NNS denotes subsets
T11373 18865-18866 -LRB- denotes (
T11374 18866-18872 NN denotes Figure
T11375 18873-18876 CD denotes S5B
T11376 18876-18877 -RRB- denotes )
T11377 18877-18878 . denotes .
T11378 18879-18889 NNP denotes Activation
T11379 18890-18892 IN denotes of
T11380 18893-18896 DT denotes the
T11381 18897-18901 NNP denotes ERK1
T11382 18902-18905 CC denotes and
T11383 18906-18910 NNP denotes ERK2
T11384 18911-18920 VBG denotes signaling
T11385 18921-18928 NN denotes pathway
T11386 18929-18931 VBZ denotes is
T11387 18932-18941 RB denotes therefore
T11388 18942-18943 DT denotes a
T11389 18944-18950 JJ denotes common
T11390 18951-18962 NN denotes requirement
T11391 18963-18966 IN denotes for
T11392 18967-18970 DT denotes the
T11393 18971-18980 NN denotes induction
T11394 18981-18983 IN denotes of
T11395 18984-18989 JJ denotes IL-10
T11396 18990-19000 NN denotes production
T11397 19001-19003 IN denotes by
T11398 19004-19007 NNP denotes Th1
T11399 19007-19008 , denotes ,
T11400 19009-19012 NNP denotes Th2
T11401 19012-19013 , denotes ,
T11402 19014-19017 CC denotes and
T11403 19018-19022 NNP denotes Th17
T11404 19023-19028 NNS denotes cells
T11405 19028-19029 . denotes .
T12523 19031-19036 JJ denotes c-maf
T12524 19037-19047 NNP denotes Expression
T12525 19048-19058 NNPS denotes Correlates
T12526 19059-19063 IN denotes with
T12527 19064-19069 NNP denotes IL-10
T12528 19070-19080 NNP denotes Production
T12529 19081-19083 IN denotes in
T12530 19084-19087 NNP denotes Th1
T12531 19087-19088 , denotes ,
T12532 19089-19092 NNP denotes Th2
T12533 19092-19093 , denotes ,
T12534 19094-19097 CC denotes and
T12535 19098-19102 NNP denotes Th17
T12536 19103-19108 NNP denotes Cells
T12537 19109-19111 TO denotes To
T12538 19112-19123 VB denotes investigate
T12539 19124-19131 RB denotes further
T12540 19132-19135 DT denotes the
T12541 19136-19146 JJ denotes downstream
T12542 19147-19154 NNS denotes factors
T12543 19155-19163 VBN denotes involved
T12544 19164-19166 IN denotes in
T12545 19167-19177 VBG denotes regulating
T12546 19178-19183 JJ denotes IL-10
T12547 19184-19194 NN denotes production
T12548 19194-19195 , denotes ,
T12549 19196-19198 PRP denotes we
T12550 19199-19213 VBD denotes differentiated
T12551 19214-19218 NNP denotes DO11
T12552 19218-19221 CD denotes .10
T12553 19222-19225 NNP denotes CD4
T12554 19225-19226 CD denotes +
T12555 19227-19228 NNP denotes T
T12556 19229-19234 NNS denotes cells
T12557 19235-19239 IN denotes with
T12558 19240-19250 VBG denotes increasing
T12559 19251-19256 NNS denotes doses
T12560 19257-19259 IN denotes of
T12561 19260-19263 NNP denotes OVA
T12562 19263-19264 , denotes ,
T12563 19265-19267 IN denotes in
T12564 19268-19271 DT denotes the
T12565 19272-19280 NN denotes presence
T12566 19281-19283 CC denotes or
T12567 19284-19291 NN denotes absence
T12568 19292-19294 IN denotes of
T12569 19295-19300 NN denotes IL-12
T12570 19300-19301 , denotes ,
T12571 19302-19305 CC denotes and
T12572 19306-19316 VBD denotes quantified
T12573 19317-19320 DT denotes the
T12574 19321-19331 NN denotes expression
T12575 19332-19334 IN denotes of
T12576 19335-19344 NNS denotes cytokines
T12577 19345-19348 CC denotes and
T12578 19349-19362 NN denotes transcription
T12579 19363-19370 NNS denotes factors
T12580 19371-19373 IN denotes by
T12581 19374-19383 JJ denotes real-time
T12582 19384-19390 NN denotes RT-PCR
T12583 19390-19391 . denotes .
T12584 19392-19400 JJ denotes Low-dose
T12585 19401-19408 NN denotes antigen
T12586 19409-19417 VBD denotes resulted
T12587 19418-19420 IN denotes in
T12588 19421-19434 NN denotes transcription
T12589 19435-19437 IN denotes of
T12590 19438-19441 NNP denotes Il4
T12591 19442-19445 CC denotes and
T12592 19446-19450 DT denotes this
T12593 19451-19454 VBD denotes was
T12594 19455-19464 VBN denotes abrogated
T12595 19465-19467 IN denotes by
T12596 19468-19472 DT denotes both
T12597 19473-19477 JJ denotes high
T12598 19478-19485 NN denotes antigen
T12599 19486-19491 NNS denotes doses
T12600 19492-19495 CC denotes and
T12601 19496-19501 NN denotes IL-12
T12602 19502-19503 -LRB- denotes (
T12603 19503-19509 NN denotes Figure
T12604 19510-19512 NN denotes 6A
T12605 19512-19513 -RRB- denotes )
T12606 19513-19514 . denotes .
T12607 19515-19516 DT denotes A
T12608 19517-19520 JJ denotes low
T12609 19521-19527 NN denotes amount
T12610 19528-19530 IN denotes of
T12611 19531-19544 NN denotes transcription
T12612 19545-19547 IN denotes of
T12613 19548-19552 NNP denotes Ifnγ
T12614 19553-19556 VBD denotes was
T12615 19557-19564 VBN denotes induced
T12616 19565-19567 IN denotes by
T12617 19568-19573 NN denotes IL-12
T12618 19574-19578 WRB denotes when
T12619 19579-19584 NNS denotes cells
T12620 19585-19589 VBD denotes were
T12621 19590-19604 VBN denotes differentiated
T12622 19605-19609 IN denotes with
T12623 19610-19613 JJ denotes low
T12624 19614-19621 NN denotes antigen
T12625 19622-19626 NN denotes dose
T12626 19626-19627 , denotes ,
T12627 19628-19631 CC denotes but
T12628 19632-19636 DT denotes this
T12629 19637-19643 NN denotes effect
T12630 19644-19646 IN denotes of
T12631 19647-19652 NN denotes IL-12
T12632 19653-19656 VBD denotes was
T12633 19657-19665 RB denotes markedly
T12634 19666-19677 VBN denotes upregulated
T12635 19678-19682 IN denotes with
T12636 19683-19693 VBG denotes increasing
T12637 19694-19699 NNS denotes doses
T12638 19700-19702 IN denotes of
T12639 19703-19710 NN denotes antigen
T12640 19711-19712 -LRB- denotes (
T12641 19712-19718 NN denotes Figure
T12642 19719-19721 NN denotes 6A
T12643 19721-19722 -RRB- denotes )
T12644 19722-19723 . denotes .
T12645 19724-19725 DT denotes A
T12646 19726-19729 JJ denotes low
T12647 19730-19736 NN denotes amount
T12648 19737-19739 IN denotes of
T12649 19740-19744 JJ denotes Il10
T12650 19745-19758 NN denotes transcription
T12651 19759-19762 VBD denotes was
T12652 19763-19771 VBN denotes observed
T12653 19772-19774 IN denotes at
T12654 19775-19778 JJ denotes low
T12655 19779-19784 NNS denotes doses
T12656 19785-19787 IN denotes of
T12657 19788-19795 NN denotes antigen
T12658 19796-19808 VBG denotes accompanying
T12659 19809-19812 JJ denotes Il4
T12660 19813-19823 NN denotes expression
T12661 19824-19825 -LRB- denotes (
T12662 19825-19828 JJ denotes Th2
T12663 19829-19833 NN denotes cell
T12664 19834-19842 NN denotes response
T12665 19842-19843 -RRB- denotes )
T12666 19843-19844 , denotes ,
T12667 19845-19848 CC denotes and
T12668 19849-19853 DT denotes this
T12669 19854-19857 VBD denotes was
T12670 19858-19867 VBN denotes abrogated
T12671 19868-19870 IN denotes by
T12672 19871-19880 VBN denotes increased
T12673 19881-19886 NNS denotes doses
T12674 19887-19889 IN denotes of
T12675 19890-19897 NN denotes antigen
T12676 19898-19900 IN denotes as
T12677 19901-19904 VBD denotes was
T12678 19905-19908 JJ denotes Il4
T12679 19909-19919 NN denotes expression
T12680 19920-19921 -LRB- denotes (
T12681 19921-19927 NN denotes Figure
T12682 19928-19930 NN denotes 6A
T12683 19930-19931 -RRB- denotes )
T12684 19931-19932 . denotes .
T12685 19933-19935 IN denotes At
T12686 19936-19939 JJ denotes low
T12687 19940-19945 NNS denotes doses
T12688 19946-19948 IN denotes of
T12689 19949-19956 NN denotes antigen
T12690 19956-19957 , denotes ,
T12691 19958-19963 NNP denotes IL-12
T12692 19964-19967 VBD denotes had
T12693 19968-19974 JJ denotes little
T12694 19975-19981 NN denotes effect
T12695 19982-19984 TO denotes to
T12696 19985-19993 VB denotes increase
T12697 19994-19999 NNP denotes IL-10
T12698 20000-20004 NNP denotes mRNA
T12699 20005-20015 NN denotes expression
T12700 20016-20017 -LRB- denotes (
T12701 20017-20023 NN denotes Figure
T12702 20024-20026 NN denotes 6A
T12703 20026-20027 -RRB- denotes )
T12704 20028-20030 IN denotes in
T12705 20031-20038 VBG denotes keeping
T12706 20039-20043 IN denotes with
T12707 20044-20047 DT denotes the
T12708 20048-20055 NN denotes protein
T12709 20056-20060 NNS denotes data
T12710 20061-20062 -LRB- denotes (
T12711 20062-20068 NN denotes Figure
T12712 20069-20071 CD denotes 1A
T12713 20071-20072 -RRB- denotes )
T12714 20072-20073 . denotes .
T12715 20074-20081 RB denotes However
T12716 20081-20082 , denotes ,
T12717 20083-20088 JJ denotes IL-12
T12718 20089-20096 VBD denotes induced
T12719 20097-20098 DT denotes a
T12720 20099-20103 JJ denotes high
T12721 20104-20110 NN denotes amount
T12722 20111-20113 IN denotes of
T12723 20114-20118 JJ denotes Il10
T12724 20119-20132 NN denotes transcription
T12725 20133-20135 RB denotes as
T12726 20136-20140 RB denotes well
T12727 20141-20143 IN denotes as
T12728 20144-20148 NNP denotes Ifnγ
T12729 20149-20159 NN denotes expression
T12730 20160-20164 IN denotes with
T12731 20165-20174 VBN denotes increased
T12732 20175-20182 NN denotes antigen
T12733 20183-20188 NNS denotes doses
T12734 20189-20190 -LRB- denotes (
T12735 20190-20196 NN denotes Figure
T12736 20197-20199 NN denotes 6A
T12737 20199-20200 -RRB- denotes )
T12738 20200-20201 , denotes ,
T12739 20202-20207 RB denotes again
T12740 20208-20210 IN denotes in
T12741 20211-20218 VBG denotes keeping
T12742 20219-20223 IN denotes with
T12743 20224-20227 DT denotes the
T12744 20228-20235 NN denotes protein
T12745 20236-20240 NNS denotes data
T12746 20241-20242 -LRB- denotes (
T12747 20242-20248 NN denotes Figure
T12748 20249-20251 CD denotes 1A
T12749 20251-20252 -RRB- denotes )
T12750 20252-20253 . denotes .
T12751 20254-20257 CD denotes CD4
T12752 20257-20258 CD denotes +
T12753 20259-20260 NNP denotes T
T12754 20261-20266 NNS denotes cells
T12755 20267-20281 VBN denotes differentiated
T12756 20282-20286 IN denotes with
T12757 20287-20297 VBG denotes increasing
T12758 20298-20303 NNS denotes doses
T12759 20304-20306 IN denotes of
T12760 20307-20314 NN denotes antigen
T12761 20315-20318 VBD denotes did
T12762 20319-20322 RB denotes not
T12763 20323-20330 VB denotes express
T12764 20331-20335 JJ denotes high
T12765 20336-20343 NNS denotes amounts
T12766 20344-20346 IN denotes of
T12767 20347-20353 NNP denotes Tbx-21
T12768 20354-20355 -LRB- denotes (
T12769 20355-20360 NNP denotes T-bet
T12770 20360-20361 -RRB- denotes )
T12771 20362-20366 NNP denotes mRNA
T12772 20366-20367 , denotes ,
T12773 20368-20374 IN denotes unless
T12774 20375-20379 PRP denotes they
T12775 20380-20384 VBD denotes were
T12776 20385-20395 VBN denotes cocultured
T12777 20396-20400 IN denotes with
T12778 20401-20406 NNP denotes IL-12
T12779 20407-20408 -LRB- denotes (
T12780 20408-20414 NNP denotes Figure
T12781 20415-20417 NNP denotes 6B
T12782 20417-20418 -RRB- denotes )
T12783 20418-20419 . denotes .
T12784 20420-20422 IN denotes In
T12785 20423-20431 NN denotes contrast
T12786 20431-20432 , denotes ,
T12787 20433-20437 JJ denotes high
T12788 20438-20445 NNS denotes amounts
T12789 20446-20448 IN denotes of
T12790 20449-20455 NNP denotes GATA-3
T12791 20456-20460 NNP denotes mRNA
T12792 20461-20471 NN denotes expression
T12793 20472-20476 VBD denotes were
T12794 20477-20481 RB denotes only
T12795 20482-20490 VBN denotes observed
T12796 20491-20496 IN denotes under
T12797 20497-20500 NNP denotes Th2
T12798 20501-20505 NN denotes cell
T12799 20506-20521 NN denotes differentiation
T12800 20522-20532 NNS denotes conditions
T12801 20533-20534 -LRB- denotes (
T12802 20534-20542 JJ denotes low-dose
T12803 20543-20550 NN denotes antigen
T12804 20550-20551 -RRB- denotes )
T12805 20552-20553 -LRB- denotes (
T12806 20553-20559 NN denotes Figure
T12807 20560-20562 NN denotes 6B
T12808 20562-20563 -RRB- denotes )
T12809 20563-20564 , denotes ,
T12810 20565-20568 CC denotes and
T12811 20569-20573 DT denotes this
T12812 20574-20584 NN denotes expression
T12813 20585-20588 VBD denotes was
T12814 20589-20597 RB denotes markedly
T12815 20598-20611 VBN denotes downregulated
T12816 20612-20614 IN denotes by
T12817 20615-20619 DT denotes both
T12818 20620-20630 VBG denotes increasing
T12819 20631-20638 NN denotes antigen
T12820 20639-20643 NN denotes dose
T12821 20644-20647 CC denotes and
T12822 20648-20657 NN denotes coculture
T12823 20658-20660 IN denotes in
T12824 20661-20666 NNP denotes IL-12
T12825 20667-20668 -LRB- denotes (
T12826 20668-20674 NNP denotes Figure
T12827 20675-20677 NNP denotes 6B
T12828 20677-20678 -RRB- denotes )
T12829 20678-20679 . denotes .
T12830 20680-20695 NNP denotes Differentiation
T12831 20696-20698 IN denotes of
T12832 20699-20700 NNP denotes T
T12833 20701-20706 NNS denotes cells
T12834 20707-20712 IN denotes under
T12835 20713-20716 JJ denotes low
T12836 20717-20724 NN denotes antigen
T12837 20725-20729 NN denotes dose
T12838 20730-20733 VBD denotes led
T12839 20734-20736 TO denotes to
T12840 20737-20747 NN denotes expression
T12841 20748-20750 IN denotes of
T12842 20751-20756 JJ denotes c-maf
T12843 20756-20757 , denotes ,
T12844 20758-20760 IN denotes in
T12845 20761-20768 VBG denotes keeping
T12846 20769-20773 IN denotes with
T12847 20774-20777 DT denotes the
T12848 20778-20781 NNP denotes Th2
T12849 20782-20786 NN denotes cell
T12850 20787-20794 NN denotes profile
T12851 20795-20796 -LRB- denotes (
T12852 20796-20798 NNP denotes Ho
T12853 20799-20801 FW denotes et
T12854 20802-20805 FW denotes al.
T12855 20805-20806 , denotes ,
T12856 20807-20811 CD denotes 1996
T12857 20811-20812 -RRB- denotes )
T12858 20812-20813 , denotes ,
T12859 20814-20819 WDT denotes which
T12860 20820-20823 VBD denotes was
T12861 20824-20830 RB denotes almost
T12862 20831-20841 RB denotes completely
T12863 20842-20851 VBN denotes abrogated
T12864 20852-20854 IN denotes by
T12865 20855-20865 VBG denotes increasing
T12866 20866-20871 NNS denotes doses
T12867 20872-20874 IN denotes of
T12868 20875-20882 NN denotes antigen
T12869 20883-20884 -LRB- denotes (
T12870 20884-20890 NN denotes Figure
T12871 20891-20893 NN denotes 6B
T12872 20893-20894 -RRB- denotes )
T12873 20894-20895 . denotes .
T12874 20896-20909 RB denotes Interestingly
T12875 20909-20910 , denotes ,
T12876 20911-20916 JJ denotes IL-12
T12877 20917-20926 VBD denotes sustained
T12878 20927-20930 DT denotes the
T12879 20931-20935 JJ denotes high
T12880 20936-20946 NN denotes expression
T12881 20947-20949 IN denotes of
T12882 20950-20955 NNP denotes c-Maf
T12883 20956-20960 NNP denotes mRNA
T12884 20961-20965 RB denotes even
T12885 20966-20968 IN denotes at
T12886 20969-20972 DT denotes the
T12887 20973-20980 JJS denotes highest
T12888 20981-20988 NN denotes antigen
T12889 20989-20993 NN denotes dose
T12890 20994-20995 -LRB- denotes (
T12891 20995-21001 NN denotes Figure
T12892 21002-21004 NN denotes 6B
T12893 21004-21005 -RRB- denotes )
T12894 21005-21006 . denotes .
T12895 21007-21015 RB denotes Moreover
T12896 21015-21016 , denotes ,
T12897 21017-21022 JJ denotes IL-12
T12898 21023-21034 NN denotes maintenance
T12899 21035-21037 IN denotes of
T12900 21038-21043 JJ denotes c-maf
T12901 21044-21054 NN denotes expression
T12902 21055-21063 VBN denotes required
T12903 21064-21069 CD denotes STAT4
T12904 21070-21080 NN denotes activation
T12905 21081-21082 -LRB- denotes (
T12906 21082-21086 NNS denotes data
T12907 21087-21090 RB denotes not
T12908 21091-21096 VBN denotes shown
T12909 21096-21097 -RRB- denotes )
T12910 21097-21098 . denotes .
T12911 21099-21101 IN denotes In
T12912 21102-21106 JJ denotes Th17
T12913 21107-21112 NNS denotes cells
T12914 21113-21117 WDT denotes that
T12915 21118-21127 VBD denotes expressed
T12916 21128-21134 NN denotes IL-17a
T12917 21135-21137 RB denotes as
T12918 21138-21142 RB denotes well
T12919 21143-21145 IN denotes as
T12920 21146-21151 NNP denotes IL-10
T12921 21152-21156 NNP denotes mRNA
T12922 21157-21158 -LRB- denotes (
T12923 21158-21164 NNP denotes Figure
T12924 21165-21167 NNP denotes 6C
T12925 21167-21168 -RRB- denotes )
T12926 21168-21169 , denotes ,
T12927 21170-21175 NNP denotes T-bet
T12928 21176-21179 CC denotes and
T12929 21180-21186 NNP denotes GATA-3
T12930 21187-21191 NNP denotes mRNA
T12931 21192-21196 VBD denotes were
T12932 21197-21209 JJ denotes undetectable
T12933 21210-21211 -LRB- denotes (
T12934 21211-21215 NNS denotes data
T12935 21216-21219 RB denotes not
T12936 21220-21225 VBN denotes shown
T12937 21225-21226 -RRB- denotes )
T12938 21226-21227 , denotes ,
T12939 21228-21235 IN denotes whereas
T12940 21236-21240 DT denotes that
T12941 21241-21243 IN denotes of
T12942 21244-21250 NN denotes ROR-γt
T12943 21251-21254 VBD denotes was
T12944 21255-21259 JJ denotes high
T12945 21260-21261 -LRB- denotes (
T12946 21261-21267 NN denotes Figure
T12947 21268-21270 NN denotes 6C
T12948 21270-21271 -RRB- denotes )
T12949 21272-21273 -LRB- denotes (
T12950 21273-21279 NNP denotes Ivanov
T12951 21280-21282 FW denotes et
T12952 21283-21286 FW denotes al.
T12953 21286-21287 , denotes ,
T12954 21288-21292 CD denotes 2007
T12955 21292-21293 -RRB- denotes )
T12956 21293-21294 . denotes .
T12957 21295-21299 CD denotes Th17
T12958 21300-21305 NNS denotes cells
T12959 21306-21310 RB denotes also
T12960 21311-21320 VBD denotes expressed
T12961 21321-21325 JJ denotes high
T12962 21326-21333 NNS denotes amounts
T12963 21334-21336 IN denotes of
T12964 21337-21342 JJ denotes c-maf
T12965 21343-21344 -LRB- denotes (
T12966 21344-21350 NN denotes Figure
T12967 21351-21353 NN denotes 6C
T12968 21353-21354 -RRB- denotes )
T12969 21354-21355 , denotes ,
T12970 21356-21366 VBG denotes confirming
T12971 21367-21368 DT denotes a
T12972 21369-21375 JJ denotes recent
T12973 21376-21382 NN denotes report
T12974 21383-21384 -LRB- denotes (
T12975 21384-21391 NNP denotes Bauquet
T12976 21392-21394 FW denotes et
T12977 21395-21398 FW denotes al.
T12978 21398-21399 , denotes ,
T12979 21400-21404 CD denotes 2009
T12980 21404-21405 -RRB- denotes )
T12981 21405-21406 . denotes .
T12982 21407-21412 NN denotes c-Maf
T12983 21413-21415 VBZ denotes is
T12984 21416-21425 RB denotes therefore
T12985 21426-21435 VBN denotes expressed
T12986 21436-21438 IN denotes in
T12987 21439-21442 DT denotes all
T12988 21443-21459 JJ denotes IL-10-expressing
T12989 21460-21461 NNP denotes T
T12990 21462-21466 NN denotes cell
T12991 21467-21478 NNS denotes populations
T12992 21479-21485 VBN denotes tested
T12993 21486-21487 -LRB- denotes (
T12994 21487-21494 NNS denotes Figures
T12995 21495-21497 NN denotes 6B
T12996 21498-21501 CC denotes and
T12997 21502-21504 NN denotes 6C
T12998 21504-21505 -RRB- denotes )
T12999 21506-21509 CC denotes and
T13000 21510-21513 MD denotes may
T13001 21514-21517 RB denotes not
T13002 21518-21520 VB denotes be
T13003 21521-21525 RB denotes just
T13004 21526-21527 DT denotes a
T13005 21528-21531 JJ denotes Th2
T13006 21532-21545 JJ denotes cell-specific
T13007 21546-21559 NN denotes transcription
T13008 21560-21566 NN denotes factor
T13009 21567-21569 IN denotes as
T13010 21570-21580 RB denotes originally
T13011 21581-21588 VBN denotes thought
T13012 21589-21590 -LRB- denotes (
T13013 21590-21592 NNP denotes Ho
T13014 21593-21595 FW denotes et
T13015 21596-21599 FW denotes al.
T13016 21599-21600 , denotes ,
T13017 21601-21605 CD denotes 1996
T13018 21605-21606 -RRB- denotes )
T13019 21606-21607 . denotes .
T13020 21608-21610 PRP denotes We
T13021 21611-21617 VBD denotes showed
T13022 21618-21622 RB denotes also
T13023 21623-21627 IN denotes that
T13024 21628-21632 IN denotes like
T13025 21633-21637 JJ denotes Il10
T13026 21638-21648 NN denotes expression
T13027 21648-21649 , denotes ,
T13028 21650-21655 JJ denotes c-maf
T13029 21656-21666 NN denotes expression
T13030 21667-21670 VBD denotes was
T13031 21671-21680 VBN denotes inhibited
T13032 21681-21683 IN denotes in
T13033 21684-21687 NNP denotes Th1
T13034 21688-21691 CC denotes and
T13035 21692-21696 NNP denotes Th17
T13036 21697-21702 NNS denotes cells
T13037 21703-21705 IN denotes in
T13038 21706-21709 DT denotes the
T13039 21710-21718 NN denotes presence
T13040 21719-21721 IN denotes of
T13041 21722-21725 DT denotes the
T13042 21726-21730 NNP denotes MEK1
T13043 21731-21734 CC denotes and
T13044 21735-21739 NNP denotes MEK2
T13045 21740-21749 NN denotes inhibitor
T13046 21750-21751 -LRB- denotes (
T13047 21751-21759 NNP denotes PD184352
T13048 21759-21760 -RRB- denotes )
T13049 21760-21761 , denotes ,
T13050 21762-21769 IN denotes whereas
T13051 21770-21775 NNP denotes T-bet
T13052 21776-21779 CC denotes and
T13053 21780-21785 NNP denotes RORγt
T13054 21786-21796 NN denotes expression
T13055 21797-21800 VBD denotes was
T13056 21801-21807 RB denotes hardly
T13057 21808-21816 JJ denotes affected
T13058 21817-21818 -LRB- denotes (
T13059 21818-21824 NNP denotes Figure
T13060 21825-21827 NNP denotes 6D
T13061 21827-21828 -RRB- denotes )
T13062 21828-21829 . denotes .
T15871 21842-21847 NN denotes IL-10
T15872 21848-21858 NN denotes expression
T15873 21859-21861 IN denotes by
T15874 21862-21867 NNS denotes cells
T15875 21868-21870 IN denotes of
T15876 21871-21874 DT denotes the
T15877 21875-21881 NN denotes innate
T15878 21882-21885 CC denotes and
T15879 21886-21894 JJ denotes adaptive
T15880 21895-21901 JJ denotes immune
T15881 21902-21909 NNS denotes systems
T15882 21910-21918 VBZ denotes reflects
T15883 21919-21922 DT denotes the
T15884 21923-21933 NN denotes importance
T15885 21934-21936 IN denotes of
T15886 21937-21941 DT denotes this
T15887 21942-21950 NN denotes cytokine
T15888 21951-21953 IN denotes in
T15889 21954-21957 DT denotes the
T15890 21958-21963 JJ denotes tight
T15891 21964-21974 NN denotes regulation
T15892 21975-21977 IN denotes of
T15893 21978-21981 DT denotes the
T15894 21982-21988 JJ denotes immune
T15895 21989-21997 NN denotes response
T15896 21997-21998 , denotes ,
T15897 21999-22001 TO denotes to
T15898 22002-22010 VB denotes minimize
T15899 22011-22020 NN denotes pathology
T15900 22021-22027 IN denotes during
T15901 22028-22037 NN denotes infection
T15902 22037-22038 . denotes .
T15903 22039-22044 NN denotes IL-10
T15904 22045-22055 NN denotes expression
T15905 22056-22058 IN denotes by
T15906 22059-22062 JJ denotes Th1
T15907 22063-22068 NNS denotes cells
T15908 22069-22072 VBZ denotes has
T15909 22073-22077 VBN denotes been
T15910 22078-22086 VBN denotes reported
T15911 22087-22089 TO denotes to
T15912 22090-22098 VB denotes regulate
T15913 22099-22102 DT denotes the
T15914 22103-22109 JJ denotes immune
T15915 22110-22118 NN denotes response
T15916 22119-22121 IN denotes in
T15917 22122-22135 NN denotes leishmaniasis
T15918 22136-22139 CC denotes and
T15919 22140-22153 NN denotes toxoplasmosis
T15920 22153-22154 . denotes .
T15921 22155-22162 RB denotes However
T15922 22162-22163 , denotes ,
T15923 22164-22166 IN denotes in
T15924 22167-22171 JJ denotes many
T15925 22172-22182 NNS denotes situations
T15926 22182-22183 , denotes ,
T15927 22184-22189 NN denotes IL-10
T15928 22190-22192 VBZ denotes is
T15929 22193-22196 RB denotes not
T15930 22197-22205 VBN denotes produced
T15931 22206-22208 IN denotes by
T15932 22209-22212 JJ denotes Th1
T15933 22213-22218 NNS denotes cells
T15934 22219-22221 IN denotes in
T15935 22222-22230 NN denotes response
T15936 22231-22233 TO denotes to
T15937 22234-22243 JJ denotes antigenic
T15938 22244-22255 NN denotes stimulation
T15939 22255-22256 . denotes .
T15940 22257-22260 PRP$ denotes Our
T15941 22261-22265 NN denotes goal
T15942 22266-22269 VBD denotes was
T15943 22270-22272 TO denotes to
T15944 22273-22280 VB denotes address
T15945 22281-22284 DT denotes the
T15946 22285-22294 JJ denotes molecular
T15947 22295-22302 NNS denotes signals
T15948 22303-22307 WDT denotes that
T15949 22308-22317 VBP denotes determine
T15950 22318-22325 IN denotes whether
T15951 22326-22329 JJ denotes Th1
T15952 22330-22335 NNS denotes cells
T15953 22336-22343 VBP denotes develop
T15954 22344-22346 TO denotes to
T15955 22347-22354 VB denotes produce
T15956 22355-22360 NNP denotes IL-10
T15957 22361-22362 -LRB- denotes (
T15958 22362-22372 NNP denotes Trinchieri
T15959 22372-22373 , denotes ,
T15960 22374-22378 CD denotes 2007
T15961 22378-22379 -RRB- denotes )
T15962 22379-22380 . denotes .
T15963 22381-22385 RB denotes Here
T15964 22385-22386 , denotes ,
T15965 22387-22389 PRP denotes we
T15966 22390-22396 VBD denotes showed
T15967 22397-22401 IN denotes that
T15968 22402-22405 JJ denotes Th1
T15969 22406-22411 NNS denotes cells
T15970 22412-22420 VBN denotes required
T15971 22421-22446 JJ denotes high-antigen-dose-induced
T15972 22447-22451 CD denotes ERK1
T15973 22452-22455 CC denotes and
T15974 22456-22460 CD denotes ERK2
T15975 22461-22476 NN denotes phosphorylation
T15976 22477-22480 CC denotes and
T15977 22481-22494 JJ denotes IL-12-induced
T15978 22495-22501 NN denotes STAT-4
T15979 22502-22512 NN denotes activation
T15980 22513-22515 TO denotes to
T15981 22516-22523 VB denotes produce
T15982 22524-22529 NNP denotes IL-10
T15983 22529-22530 . denotes .
T15984 22531-22534 PRP$ denotes Our
T15985 22535-22543 NNS denotes findings
T15986 22544-22548 IN denotes that
T15987 22549-22553 CD denotes ERK1
T15988 22554-22557 CC denotes and
T15989 22558-22562 CD denotes ERK2
T15990 22563-22573 NN denotes activation
T15991 22574-22577 VBD denotes was
T15992 22578-22579 DT denotes a
T15993 22580-22586 JJ denotes common
T15994 22587-22594 NN denotes pathway
T15995 22595-22603 VBN denotes required
T15996 22604-22607 IN denotes for
T15997 22608-22611 DT denotes the
T15998 22612-22622 NN denotes production
T15999 22623-22625 IN denotes of
T16000 22626-22631 NN denotes IL-10
T16001 22632-22634 IN denotes by
T16002 22635-22638 NNP denotes Th1
T16003 22638-22639 , denotes ,
T16004 22640-22643 NNP denotes Th2
T16005 22643-22644 , denotes ,
T16006 22645-22648 CC denotes and
T16007 22649-22653 NNP denotes Th17
T16008 22654-22658 NN denotes cell
T16009 22659-22666 NNS denotes subsets
T16010 22666-22667 , denotes ,
T16011 22668-22673 WDT denotes which
T16012 22674-22687 VBP denotes differentiate
T16013 22688-22693 IN denotes along
T16014 22694-22702 JJ denotes distinct
T16015 22703-22711 NNS denotes pathways
T16016 22711-22712 , denotes ,
T16017 22713-22717 JJ denotes such
T16018 22718-22722 IN denotes that
T16019 22723-22728 JJ denotes IL-10
T16020 22729-22737 VBZ denotes provides
T16021 22738-22739 DT denotes a
T16022 22740-22746 RB denotes highly
T16023 22747-22756 VBN denotes regulated
T16024 22757-22765 NN denotes feedback
T16025 22766-22770 NN denotes loop
T16026 22771-22773 TO denotes to
T16027 22774-22779 VB denotes avoid
T16028 22780-22783 DT denotes the
T16029 22784-22792 NNS denotes extremes
T16030 22793-22795 IN denotes of
T16031 22796-22805 JJ denotes excessive
T16032 22806-22818 NN denotes inflammation
T16033 22819-22821 CC denotes or
T16034 22822-22829 NN denotes chronic
T16035 22830-22840 NNS denotes infections
T16036 22841-22844 CC denotes and
T16037 22845-22849 RB denotes also
T16038 22850-22855 VB denotes allow
T16039 22856-22857 DT denotes a
T16040 22858-22868 JJ denotes protective
T16041 22869-22877 NN denotes response
T16042 22878-22880 TO denotes to
T16043 22881-22888 JJ denotes diverse
T16044 22889-22898 NNS denotes pathogens
T16045 22898-22899 . denotes .
T16046 22900-22902 IN denotes In
T16047 22903-22910 JJ denotes certain
T16048 22911-22916 JJ denotes viral
T16049 22917-22919 CC denotes or
T16050 22920-22929 JJ denotes parasitic
T16051 22930-22940 NNS denotes infections
T16052 22941-22942 -LRB- denotes (
T16053 22942-22950 NNP denotes Anderson
T16054 22951-22953 FW denotes et
T16055 22954-22957 FW denotes al.
T16056 22957-22958 , denotes ,
T16057 22959-22963 CD denotes 2007
T16058 22963-22964 : denotes ;
T16059 22965-22971 NNP denotes Brooks
T16060 22972-22974 FW denotes et
T16061 22975-22978 FW denotes al.
T16062 22978-22979 , denotes ,
T16063 22980-22984 CD denotes 2006
T16064 22984-22985 : denotes ;
T16065 22986-22993 NNP denotes Ejrnaes
T16066 22994-22996 FW denotes et
T16067 22997-23000 FW denotes al.
T16068 23000-23001 , denotes ,
T16069 23002-23006 CD denotes 2006
T16070 23006-23007 -RRB- denotes )
T16071 23007-23008 , denotes ,
T16072 23009-23013 JJ denotes high
T16073 23014-23021 NNS denotes amounts
T16074 23022-23024 IN denotes of
T16075 23025-23036 NN denotes stimulation
T16076 23037-23040 MD denotes may
T16077 23041-23045 VB denotes lead
T16078 23046-23048 TO denotes to
T16079 23049-23052 DT denotes the
T16080 23053-23060 JJ denotes chronic
T16081 23061-23071 JJ denotes nonhealing
T16082 23072-23081 NN denotes infection
T16083 23082-23087 VBN denotes shown
T16084 23088-23090 TO denotes to
T16085 23091-23093 VB denotes be
T16086 23094-23103 VBN denotes regulated
T16087 23104-23106 IN denotes by
T16088 23107-23112 NNP denotes IL-10
T16089 23112-23113 . denotes .
T16090 23114-23120 IN denotes During
T16091 23121-23124 DT denotes the
T16092 23125-23131 NN denotes course
T16093 23132-23134 IN denotes of
T16094 23135-23144 NN denotes infection
T16095 23144-23145 , denotes ,
T16096 23146-23151 IN denotes after
T16097 23152-23159 JJ denotes initial
T16098 23160-23170 VBG denotes triggering
T16099 23171-23175 IN denotes with
T16100 23176-23183 NN denotes antigen
T16101 23183-23184 , denotes ,
T16102 23185-23186 NNP denotes T
T16103 23187-23192 NNS denotes cells
T16104 23193-23200 VBP denotes migrate
T16105 23201-23203 TO denotes to
T16106 23204-23207 DT denotes the
T16107 23208-23214 NN denotes tissue
T16108 23215-23227 VBG denotes encountering
T16109 23228-23232 JJ denotes high
T16110 23233-23238 NNS denotes doses
T16111 23239-23241 IN denotes of
T16112 23242-23249 NN denotes antigen
T16113 23250-23253 CC denotes and
T16114 23254-23261 NNS denotes factors
T16115 23262-23270 VBN denotes produced
T16116 23271-23273 IN denotes by
T16117 23274-23277 DT denotes the
T16118 23278-23284 NN denotes innate
T16119 23285-23291 JJ denotes immune
T16120 23292-23300 NN denotes response
T16121 23300-23301 . denotes .
T16122 23302-23307 IN denotes Under
T16123 23308-23313 DT denotes these
T16124 23314-23324 NNS denotes conditions
T16125 23324-23325 , denotes ,
T16126 23326-23328 PRP denotes we
T16127 23329-23338 VBP denotes speculate
T16128 23339-23343 IN denotes that
T16129 23344-23347 JJ denotes Th1
T16130 23348-23353 NNS denotes cells
T16131 23354-23358 MD denotes will
T16132 23359-23361 VB denotes be
T16133 23362-23369 VBN denotes induced
T16134 23370-23372 TO denotes to
T16135 23373-23380 VB denotes express
T16136 23381-23385 JJ denotes high
T16137 23386-23393 NNS denotes amounts
T16138 23394-23396 IN denotes of
T16139 23397-23402 NNP denotes IL-10
T16140 23402-23403 , denotes ,
T16141 23404-23406 IN denotes in
T16142 23407-23414 VBG denotes keeping
T16143 23415-23419 IN denotes with
T16144 23420-23427 NNS denotes reports
T16145 23428-23432 IN denotes that
T16146 23433-23448 JJ denotes IL-10-producing
T16147 23449-23452 JJ denotes Th1
T16148 23453-23458 NNS denotes cells
T16149 23459-23463 VBD denotes were
T16150 23464-23469 VBN denotes found
T16151 23470-23472 IN denotes in
T16152 23473-23476 CD denotes CD4
T16153 23476-23477 CD denotes +
T16154 23478-23484 NNS denotes clones
T16155 23485-23493 VBN denotes isolated
T16156 23494-23498 IN denotes from
T16157 23499-23502 NNP denotes BAL
T16158 23503-23506 CC denotes but
T16159 23507-23510 RB denotes not
T16160 23511-23516 NN denotes blood
T16161 23517-23519 IN denotes of
T16162 23520-23522 NN denotes TB
T16163 23523-23531 NNS denotes patients
T16164 23532-23533 -LRB- denotes (
T16165 23533-23539 NNP denotes Gerosa
T16166 23540-23542 FW denotes et
T16167 23543-23546 FW denotes al.
T16168 23546-23547 , denotes ,
T16169 23548-23552 CD denotes 1999
T16170 23552-23553 -RRB- denotes )
T16171 23553-23554 . denotes .
T16172 23555-23564 RB denotes Similarly
T16173 23564-23565 , denotes ,
T16174 23566-23569 DT denotes the
T16175 23570-23576 JJ denotes immune
T16176 23577-23585 NN denotes response
T16177 23586-23588 TO denotes to
T16178 23589-23590 DT denotes a
T16179 23591-23599 JJ denotes clinical
T16180 23600-23607 VB denotes isolate
T16181 23608-23610 IN denotes of
T16182 23611-23613 NNP denotes L.
T16183 23614-23619 JJ denotes major
T16184 23619-23620 , denotes ,
T16185 23621-23626 WDT denotes which
T16186 23627-23635 VBZ denotes produces
T16187 23636-23643 RB denotes heavily
T16188 23644-23652 JJ denotes infected
T16189 23653-23663 JJ denotes nonhealing
T16190 23664-23671 NNS denotes lesions
T16191 23671-23672 , denotes ,
T16192 23673-23676 VBD denotes was
T16193 23677-23682 VBN denotes found
T16194 23683-23685 TO denotes to
T16195 23686-23688 VB denotes be
T16196 23689-23698 VBN denotes regulated
T16197 23699-23701 IN denotes by
T16198 23702-23707 JJ denotes IL-10
T16199 23708-23715 VBN denotes derived
T16200 23716-23720 IN denotes from
T16201 23721-23726 NNP denotes Foxp3
T16202 23726-23727 NNP denotes −
T16203 23728-23731 NNP denotes Th1
T16204 23732-23737 NNS denotes cells
T16205 23738-23742 WDT denotes that
T16206 23743-23752 VBP denotes coproduce
T16207 23753-23758 NNP denotes IL-10
T16208 23759-23762 CC denotes and
T16209 23763-23768 NNP denotes IFN-γ
T16210 23769-23770 -LRB- denotes (
T16211 23770-23778 NNP denotes Anderson
T16212 23779-23781 FW denotes et
T16213 23782-23785 FW denotes al.
T16214 23785-23786 , denotes ,
T16215 23787-23791 CD denotes 2007
T16216 23791-23792 -RRB- denotes )
T16217 23792-23793 , denotes ,
T16218 23794-23797 CC denotes and
T16219 23798-23801 DT denotes the
T16220 23802-23808 JJ denotes immune
T16221 23809-23817 NN denotes response
T16222 23818-23824 IN denotes during
T16223 23825-23827 NNP denotes T.
T16224 23828-23834 NNS denotes gondii
T16225 23835-23844 NN denotes infection
T16226 23845-23848 VBD denotes was
T16227 23849-23854 VBN denotes found
T16228 23855-23859 RB denotes also
T16229 23860-23862 TO denotes to
T16230 23863-23865 VB denotes be
T16231 23866-23875 VBN denotes regulated
T16232 23876-23878 IN denotes by
T16233 23879-23884 NNP denotes Foxp3
T16234 23884-23885 NNP denotes −
T16235 23886-23889 NNP denotes Th1
T16236 23890-23895 NNS denotes cells
T16237 23896-23897 -LRB- denotes (
T16238 23897-23905 JJ denotes Jankovic
T16239 23906-23908 FW denotes et
T16240 23909-23912 FW denotes al.
T16241 23912-23913 , denotes ,
T16242 23914-23918 CD denotes 2007
T16243 23918-23919 -RRB- denotes )
T16244 23919-23920 . denotes .
T16245 23921-23923 PRP denotes It
T16246 23924-23926 VBZ denotes is
T16247 23927-23933 JJ denotes likely
T16248 23934-23938 IN denotes that
T16249 23939-23944 JJ denotes IL-10
T16250 23945-23955 NN denotes production
T16251 23956-23958 IN denotes by
T16252 23959-23962 JJ denotes Th1
T16253 23963-23968 NNS denotes cells
T16254 23969-23971 VBZ denotes is
T16255 23972-23978 VBN denotes evoked
T16256 23979-23984 IN denotes under
T16257 23985-23995 NNS denotes conditions
T16258 23996-23998 IN denotes of
T16259 23999-24003 JJ denotes high
T16260 24004-24016 NN denotes inflammation
T16261 24017-24020 CC denotes and
T16262 24021-24030 JJ denotes antigenic
T16263 24031-24042 NN denotes stimulation
T16264 24042-24043 , denotes ,
T16265 24044-24051 IN denotes whereas
T16266 24052-24062 JJ denotes regulatory
T16267 24063-24066 NNP denotes CD4
T16268 24066-24067 CD denotes +
T16269 24068-24069 NNP denotes T
T16270 24070-24075 NNS denotes cells
T16271 24076-24085 VBG denotes producing
T16272 24086-24091 NN denotes IL-10
T16273 24092-24095 MD denotes may
T16274 24096-24103 VB denotes operate
T16275 24104-24106 TO denotes to
T16276 24107-24115 VB denotes regulate
T16277 24116-24119 DT denotes the
T16278 24120-24126 JJ denotes immune
T16279 24127-24135 NN denotes response
T16280 24136-24141 IN denotes under
T16281 24142-24152 NNS denotes conditions
T16282 24153-24155 IN denotes in
T16283 24156-24161 WDT denotes which
T16284 24162-24165 DT denotes the
T16285 24166-24174 NN denotes pathogen
T16286 24175-24177 VBZ denotes is
T16287 24178-24188 RB denotes clinically
T16288 24189-24199 VBN denotes controlled
T16289 24199-24200 , denotes ,
T16290 24201-24205 JJ denotes such
T16291 24206-24208 IN denotes as
T16292 24209-24211 IN denotes in
T16293 24212-24221 NN denotes infection
T16294 24222-24226 IN denotes with
T16295 24227-24229 NNP denotes L.
T16296 24230-24235 JJ denotes major
T16297 24236-24237 -LRB- denotes (
T16298 24237-24245 NNP denotes Friedlin
T16299 24246-24252 NN denotes strain
T16300 24252-24253 -RRB- denotes )
T16301 24254-24255 -LRB- denotes (
T16302 24255-24262 NNP denotes Belkaid
T16303 24263-24265 FW denotes et
T16304 24266-24269 FW denotes al.
T16305 24269-24270 , denotes ,
T16306 24271-24275 CD denotes 2002
T16307 24275-24276 : denotes ;
T16308 24277-24283 NNP denotes Suffia
T16309 24284-24286 FW denotes et
T16310 24287-24290 FW denotes al.
T16311 24290-24291 , denotes ,
T16312 24292-24296 CD denotes 2006
T16313 24296-24297 -RRB- denotes )
T16314 24297-24298 . denotes .
T16315 24299-24301 PRP denotes We
T16316 24302-24305 RB denotes now
T16317 24306-24310 RB denotes also
T16318 24311-24319 VBD denotes reported
T16319 24320-24324 IN denotes that
T16320 24325-24328 CD denotes CD4
T16321 24328-24329 CD denotes +
T16322 24330-24331 NNP denotes T
T16323 24332-24337 NNS denotes cells
T16324 24338-24346 VBD denotes cultured
T16325 24347-24351 IN denotes with
T16326 24352-24356 JJ denotes high
T16327 24357-24364 NN denotes antigen
T16328 24365-24369 NN denotes dose
T16329 24370-24373 CC denotes and
T16330 24374-24379 NN denotes IL-12
T16331 24380-24393 VBP denotes differentiate
T16332 24394-24398 IN denotes into
T16333 24399-24408 JJ denotes canonical
T16334 24409-24412 JJ denotes Th1
T16335 24413-24421 NN denotes effector
T16336 24422-24427 NNS denotes cells
T16337 24427-24428 , denotes ,
T16338 24429-24434 WDT denotes which
T16339 24434-24435 , denotes ,
T16340 24436-24438 IN denotes in
T16341 24439-24447 NN denotes addition
T16342 24448-24450 TO denotes to
T16343 24451-24461 VBG denotes expressing
T16344 24462-24467 JJ denotes large
T16345 24468-24475 NNS denotes amounts
T16346 24476-24478 IN denotes of
T16347 24479-24484 NNP denotes IFN-γ
T16348 24485-24488 CC denotes and
T16349 24489-24494 NNP denotes IL-10
T16350 24494-24495 , denotes ,
T16351 24496-24500 VBP denotes lose
T16352 24501-24506 PRP$ denotes their
T16353 24507-24511 NN denotes IL-2
T16354 24512-24522 NN denotes expression
T16355 24523-24525 IN denotes as
T16356 24526-24535 VBN denotes described
T16357 24536-24542 IN denotes before
T16358 24543-24545 IN denotes in
T16359 24546-24553 JJ denotes certain
T16360 24554-24561 JJ denotes chronic
T16361 24562-24571 NN denotes infection
T16362 24572-24578 NNS denotes models
T16363 24579-24580 -LRB- denotes (
T16364 24580-24588 NNP denotes Sallusto
T16365 24589-24591 FW denotes et
T16366 24592-24595 FW denotes al.
T16367 24595-24596 , denotes ,
T16368 24597-24601 CD denotes 2004
T16369 24601-24602 -RRB- denotes )
T16370 24602-24603 . denotes .
T16371 24604-24607 PRP$ denotes Our
T16372 24608-24621 NN denotes demonstration
T16373 24622-24626 IN denotes that
T16374 24627-24631 NN denotes loss
T16375 24632-24634 IN denotes of
T16376 24635-24639 NN denotes IL-2
T16377 24640-24642 VBZ denotes is
T16378 24643-24654 VBN denotes accompanied
T16379 24655-24657 IN denotes by
T16380 24658-24668 NN denotes production
T16381 24669-24671 IN denotes of
T16382 24672-24677 NNP denotes IL-10
T16383 24678-24684 VBZ denotes offers
T16384 24685-24694 JJ denotes potential
T16385 24695-24705 JJ denotes additional
T16386 24706-24716 NNS denotes mechanisms
T16387 24717-24724 WRB denotes whereby
T16388 24725-24733 NN denotes effector
T16389 24734-24735 NNP denotes T
T16390 24736-24740 NN denotes cell
T16391 24741-24750 NNS denotes responses
T16392 24751-24754 MD denotes may
T16393 24755-24757 VB denotes be
T16394 24758-24766 VBN denotes dampened
T16395 24767-24773 IN denotes during
T16396 24774-24781 JJ denotes chronic
T16397 24782-24789 NN denotes disease
T16398 24789-24790 . denotes .
T16399 24791-24796 VBG denotes Using
T16400 24797-24799 DT denotes an
T16401 24800-24802 IN denotes in
T16402 24803-24807 NN denotes vivo
T16403 24808-24816 NN denotes transfer
T16404 24817-24822 NN denotes model
T16405 24823-24825 IN denotes of
T16406 24826-24830 NNP denotes DO11
T16407 24830-24833 CD denotes .10
T16408 24834-24837 NNP denotes TCR
T16409 24838-24848 JJ denotes transgenic
T16410 24849-24854 NNS denotes cells
T16411 24855-24856 -LRB- denotes (
T16412 24856-24862 NNP denotes Castro
T16413 24863-24865 FW denotes et
T16414 24866-24869 FW denotes al.
T16415 24869-24870 , denotes ,
T16416 24871-24875 CD denotes 2000
T16417 24875-24876 -RRB- denotes )
T16418 24876-24877 , denotes ,
T16419 24878-24880 PRP denotes we
T16420 24881-24887 VBD denotes showed
T16421 24888-24892 IN denotes that
T16422 24893-24908 JJ denotes IL-10-producing
T16423 24909-24912 JJ denotes Th1
T16424 24913-24918 NNS denotes cells
T16425 24919-24923 VBD denotes were
T16426 24924-24938 VBN denotes differentiated
T16427 24939-24941 IN denotes in
T16428 24942-24945 DT denotes the
T16429 24946-24954 NN denotes presence
T16430 24955-24957 IN denotes of
T16431 24958-24962 JJ denotes high
T16432 24963-24968 NNS denotes doses
T16433 24969-24971 IN denotes of
T16434 24972-24975 NNP denotes OVA
T16435 24976-24983 NN denotes protein
T16436 24984-24987 CC denotes and
T16437 24988-24991 NNP denotes LPS
T16438 24991-24992 . denotes .
T16439 24993-24995 PRP denotes We
T16440 24996-25002 VBD denotes showed
T16441 25003-25007 RB denotes here
T16442 25008-25012 IN denotes that
T16443 25013-25017 DT denotes this
T16444 25018-25027 NN denotes induction
T16445 25028-25030 IN denotes of
T16446 25031-25036 NNP denotes IL-10
T16447 25037-25039 IN denotes in
T16448 25040-25043 NNP denotes Th1
T16449 25044-25049 NNS denotes cells
T16450 25050-25052 IN denotes in
T16451 25053-25057 NN denotes vivo
T16452 25058-25061 VBD denotes was
T16453 25062-25070 RB denotes markedly
T16454 25070-25071 , denotes ,
T16455 25072-25075 CC denotes but
T16456 25076-25079 RB denotes not
T16457 25080-25087 RB denotes totally
T16458 25087-25088 , denotes ,
T16459 25089-25096 VBN denotes reduced
T16460 25097-25099 IN denotes in
T16461 25100-25115 JJ denotes STAT4-deficient
T16462 25116-25117 NNP denotes T
T16463 25118-25123 NNS denotes cells
T16464 25124-25126 IN denotes as
T16465 25127-25135 VBN denotes observed
T16466 25136-25142 IN denotes during
T16467 25143-25145 NNP denotes T.
T16468 25146-25152 NNS denotes gondii
T16469 25153-25162 NN denotes infection
T16470 25163-25164 -LRB- denotes (
T16471 25164-25172 JJ denotes Jankovic
T16472 25173-25175 FW denotes et
T16473 25176-25179 FW denotes al.
T16474 25179-25180 , denotes ,
T16475 25181-25185 CD denotes 2002
T16476 25185-25186 -RRB- denotes )
T16477 25186-25187 . denotes .
T16478 25188-25189 DT denotes A
T16479 25190-25194 JJ denotes high
T16480 25195-25204 JJ denotes antigenic
T16481 25205-25215 NN denotes activation
T16482 25216-25222 IN denotes during
T16483 25223-25225 NNP denotes T.
T16484 25226-25232 NNP denotes gondii
T16485 25233-25242 NN denotes infection
T16486 25243-25245 CC denotes or
T16487 25246-25250 JJ denotes high
T16488 25251-25258 NN denotes antigen
T16489 25259-25264 NNS denotes doses
T16490 25265-25274 VBN denotes delivered
T16491 25275-25277 IN denotes in
T16492 25278-25281 DT denotes the
T16493 25282-25290 NN denotes presence
T16494 25291-25293 IN denotes of
T16495 25294-25297 NNP denotes LPS
T16496 25297-25298 , denotes ,
T16497 25299-25301 RB denotes as
T16498 25302-25306 VBN denotes seen
T16499 25307-25309 IN denotes in
T16500 25310-25313 PRP$ denotes our
T16501 25314-25320 NN denotes system
T16502 25320-25321 , denotes ,
T16503 25322-25325 MD denotes may
T16504 25326-25336 VB denotes compensate
T16505 25337-25340 IN denotes for
T16506 25341-25343 DT denotes an
T16507 25344-25352 JJ denotes absolute
T16508 25353-25364 NN denotes requirement
T16509 25365-25368 IN denotes for
T16510 25369-25374 NN denotes IL-12
T16511 25375-25377 IN denotes in
T16512 25378-25381 DT denotes the
T16513 25382-25391 NN denotes induction
T16514 25392-25394 IN denotes of
T16515 25395-25400 NN denotes IL-10
T16516 25401-25403 IN denotes by
T16517 25404-25407 JJ denotes Th1
T16518 25408-25413 NNS denotes cells
T16519 25413-25414 . denotes .
T16520 25415-25417 IN denotes In
T16521 25418-25421 PRP$ denotes our
T16522 25422-25424 IN denotes in
T16523 25425-25430 NN denotes vitro
T16524 25431-25437 NN denotes system
T16525 25437-25438 , denotes ,
T16526 25439-25447 VBN denotes repeated
T16527 25448-25459 NN denotes stimulation
T16528 25460-25462 IN denotes of
T16529 25463-25466 JJ denotes Th1
T16530 25467-25472 NNS denotes cells
T16531 25473-25477 IN denotes with
T16532 25478-25482 JJ denotes high
T16533 25483-25490 NN denotes antigen
T16534 25491-25496 NNS denotes doses
T16535 25497-25504 VBD denotes allowed
T16536 25505-25508 DT denotes the
T16537 25509-25520 NN denotes development
T16538 25521-25523 IN denotes of
T16539 25524-25527 JJ denotes Th1
T16540 25528-25533 NNS denotes cells
T16541 25534-25543 VBG denotes producing
T16542 25544-25549 NN denotes IL-10
T16543 25550-25552 IN denotes in
T16544 25553-25555 DT denotes an
T16545 25556-25571 JJ denotes IL-12-dependent
T16546 25572-25578 NN denotes manner
T16547 25578-25579 . denotes .
T16548 25580-25585 NN denotes IL-10
T16549 25586-25596 NN denotes production
T16550 25597-25599 IN denotes by
T16551 25600-25603 JJ denotes Th1
T16552 25604-25609 NNS denotes cells
T16553 25610-25617 VBN denotes induced
T16554 25618-25620 IN denotes by
T16555 25621-25625 JJ denotes high
T16556 25626-25633 NN denotes antigen
T16557 25634-25638 NN denotes dose
T16558 25639-25642 CC denotes and
T16559 25643-25648 NN denotes IL-12
T16560 25649-25652 VBD denotes was
T16561 25653-25664 JJ denotes independent
T16562 25665-25667 IN denotes of
T16563 25668-25673 NNP denotes IFN-γ
T16564 25673-25674 , denotes ,
T16565 25675-25677 IN denotes in
T16566 25678-25685 VBG denotes keeping
T16567 25686-25690 IN denotes with
T16568 25691-25699 JJ denotes previous
T16569 25700-25708 NNS denotes findings
T16570 25709-25710 -LRB- denotes (
T16571 25710-25718 JJ denotes Jankovic
T16572 25719-25721 FW denotes et
T16573 25722-25725 FW denotes al.
T16574 25725-25726 , denotes ,
T16575 25727-25731 CD denotes 2002
T16576 25731-25732 -RRB- denotes )
T16577 25732-25733 . denotes .
T16578 25734-25741 RB denotes However
T16579 25741-25742 , denotes ,
T16580 25743-25744 DT denotes a
T16581 25745-25749 NN denotes role
T16582 25750-25753 IN denotes for
T16583 25754-25759 NNP denotes IFN-γ
T16584 25760-25762 IN denotes in
T16585 25763-25772 VBG denotes mediating
T16586 25773-25778 NNP denotes IL-10
T16587 25779-25791 NN denotes reactivation
T16588 25792-25794 IN denotes by
T16589 25795-25798 JJ denotes Th1
T16590 25799-25804 NNS denotes cells
T16591 25805-25811 IN denotes during
T16592 25812-25821 JJ denotes secondary
T16593 25822-25831 NN denotes infection
T16594 25832-25836 IN denotes with
T16595 25837-25839 NNP denotes T.
T16596 25840-25846 NNP denotes gondii
T16597 25847-25850 VBZ denotes has
T16598 25851-25855 VBN denotes been
T16599 25856-25865 VBN denotes suggested
T16600 25866-25867 -LRB- denotes (
T16601 25867-25871 NNP denotes Shaw
T16602 25872-25874 FW denotes et
T16603 25875-25878 FW denotes al.
T16604 25878-25879 , denotes ,
T16605 25880-25884 CD denotes 2006
T16606 25884-25885 -RRB- denotes )
T16607 25885-25886 . denotes .
T16608 25887-25889 PRP denotes We
T16609 25890-25894 VBP denotes have
T16610 25895-25900 VBN denotes found
T16611 25901-25905 IN denotes that
T16612 25906-25909 CD denotes CD4
T16613 25909-25910 CD denotes +
T16614 25911-25912 NNP denotes T
T16615 25913-25918 NNS denotes cells
T16616 25919-25926 VBN denotes exposed
T16617 25927-25929 TO denotes to
T16618 25930-25931 DT denotes a
T16619 25932-25936 JJ denotes high
T16620 25937-25941 NN denotes dose
T16621 25942-25944 IN denotes of
T16622 25945-25952 NN denotes antigen
T16623 25953-25955 VBP denotes do
T16624 25956-25959 RB denotes not
T16625 25960-25967 VB denotes express
T16626 25968-25973 NNP denotes IL-10
T16627 25974-25978 IN denotes upon
T16628 25979-25992 NN denotes restimulation
T16629 25992-25993 , denotes ,
T16630 25994-25997 CC denotes but
T16631 25998-26001 MD denotes can
T16632 26002-26004 VB denotes be
T16633 26005-26012 VBN denotes induced
T16634 26013-26015 TO denotes to
T16635 26016-26023 VB denotes produce
T16636 26024-26029 NNP denotes IL-10
T16637 26030-26034 IN denotes upon
T16638 26035-26046 NN denotes re-exposure
T16639 26047-26049 TO denotes to
T16640 26050-26051 DT denotes a
T16641 26052-26056 JJ denotes high
T16642 26057-26061 NN denotes dose
T16643 26062-26064 IN denotes of
T16644 26065-26072 NN denotes antigen
T16645 26073-26075 IN denotes in
T16646 26076-26079 DT denotes the
T16647 26080-26086 NN denotes recall
T16648 26087-26092 NN denotes phase
T16649 26093-26095 IN denotes in
T16650 26096-26099 DT denotes the
T16651 26100-26107 NN denotes absence
T16652 26108-26110 IN denotes of
T16653 26111-26116 VBN denotes added
T16654 26117-26122 NN denotes IL-12
T16655 26122-26123 . denotes .
T16656 26124-26131 RB denotes However
T16657 26131-26132 , denotes ,
T16658 26133-26137 DT denotes this
T16659 26138-26140 VBZ denotes is
T16660 26141-26150 JJ denotes dependent
T16661 26151-26153 IN denotes on
T16662 26154-26157 DT denotes the
T16663 26158-26167 NN denotes induction
T16664 26168-26170 IN denotes of
T16665 26171-26176 NN denotes IL-12
T16666 26177-26179 IN denotes by
T16667 26180-26198 JJ denotes antigen-presenting
T16668 26199-26202 NNS denotes DCs
T16669 26202-26203 . denotes .
T16670 26204-26207 DT denotes The
T16671 26208-26219 NN denotes combination
T16672 26220-26222 IN denotes of
T16673 26223-26227 DT denotes both
T16674 26228-26232 JJ denotes high
T16675 26233-26240 NN denotes antigen
T16676 26241-26245 NN denotes dose
T16677 26246-26249 CC denotes and
T16678 26250-26255 NN denotes IL-12
T16679 26256-26264 VBD denotes resulted
T16680 26265-26267 IN denotes in
T16681 26268-26271 DT denotes the
T16682 26272-26279 JJS denotes highest
T16683 26280-26286 NNS denotes levels
T16684 26287-26289 IN denotes of
T16685 26290-26295 JJ denotes IL-10
T16686 26296-26306 NN denotes production
T16687 26307-26310 CC denotes and
T16688 26311-26321 VBN denotes correlated
T16689 26322-26326 IN denotes with
T16690 26327-26330 DT denotes the
T16691 26331-26335 JJ denotes high
T16692 26336-26342 NNS denotes levels
T16693 26343-26345 IN denotes of
T16694 26346-26350 CD denotes ERK1
T16695 26351-26354 CC denotes and
T16696 26355-26359 CD denotes ERK2
T16697 26360-26370 NN denotes activation
T16698 26370-26371 . denotes .
T16699 26372-26375 DT denotes The
T16700 26376-26385 VBN denotes increased
T16701 26386-26396 NN denotes expression
T16702 26397-26399 IN denotes of
T16703 26400-26405 JJ denotes IFN-γ
T16704 26406-26414 VBN denotes observed
T16705 26415-26421 IN denotes during
T16706 26422-26425 DT denotes the
T16707 26426-26435 JJ denotes secondary
T16708 26436-26441 NN denotes phase
T16709 26442-26446 MD denotes will
T16710 26447-26453 VB denotes induce
T16711 26454-26463 VBN denotes increased
T16712 26464-26469 JJ denotes IL-12
T16713 26470-26480 NN denotes production
T16714 26481-26483 IN denotes by
T16715 26484-26487 NNP denotes DCs
T16716 26488-26491 CC denotes and
T16717 26492-26500 VBZ denotes suggests
T16718 26501-26505 IN denotes that
T16719 26506-26514 VBN denotes repeated
T16720 26515-26525 JJ denotes high-level
T16721 26526-26529 NNP denotes TCR
T16722 26530-26540 NN denotes activation
T16723 26541-26546 VBZ denotes feeds
T16724 26547-26551 RB denotes back
T16725 26552-26554 TO denotes to
T16726 26555-26565 VB denotes upregulate
T16727 26566-26571 JJ denotes IL-12
T16728 26572-26582 NN denotes production
T16729 26583-26585 IN denotes by
T16730 26586-26588 NNP denotes DC
T16731 26588-26589 . denotes .
T16732 26590-26592 PRP denotes It
T16733 26593-26595 VBZ denotes is
T16734 26596-26600 RB denotes thus
T16735 26601-26607 JJ denotes likely
T16736 26608-26612 IN denotes that
T16737 26613-26615 IN denotes in
T16738 26616-26618 NNP denotes T.
T16739 26619-26625 NNS denotes gondii
T16740 26626-26635 NN denotes infection
T16741 26636-26638 IN denotes in
T16742 26639-26643 NN denotes vivo
T16743 26644-26645 -LRB- denotes (
T16744 26645-26649 NNP denotes Shaw
T16745 26650-26652 FW denotes et
T16746 26653-26656 FW denotes al.
T16747 26656-26657 , denotes ,
T16748 26658-26662 CD denotes 2006
T16749 26662-26663 -RRB- denotes )
T16750 26663-26664 , denotes ,
T16751 26665-26668 DT denotes the
T16752 26669-26680 NN denotes requirement
T16753 26681-26684 IN denotes for
T16754 26685-26690 NNP denotes IFN-γ
T16755 26691-26693 TO denotes to
T16756 26694-26700 VB denotes induce
T16757 26701-26706 NNP denotes IL-10
T16758 26706-26707 , denotes ,
T16759 26708-26711 VBD denotes was
T16760 26712-26715 IN denotes for
T16761 26716-26724 NN denotes feedback
T16762 26725-26737 NN denotes upregulation
T16763 26738-26740 IN denotes of
T16764 26741-26746 NN denotes IL-12
T16765 26747-26749 IN denotes by
T16766 26750-26753 NNP denotes DCs
T16767 26753-26754 , denotes ,
T16768 26755-26760 WDT denotes which
T16769 26761-26763 IN denotes in
T16770 26764-26768 NN denotes turn
T16771 26769-26776 VBD denotes induced
T16772 26777-26782 NNP denotes IL-10
T16773 26783-26785 IN denotes in
T16774 26786-26789 DT denotes the
T16775 26790-26793 JJ denotes Th1
T16776 26794-26799 NNS denotes cells
T16777 26799-26800 . denotes .
T16778 26801-26809 IN denotes Although
T16779 26810-26815 NNP denotes IL-10
T16780 26816-26819 MD denotes may
T16781 26820-26822 VB denotes be
T16782 26823-26837 RB denotes differentially
T16783 26838-26847 VBN denotes regulated
T16784 26848-26850 IN denotes in
T16785 26851-26854 NNP denotes Th1
T16786 26855-26858 CC denotes and
T16787 26859-26862 NNP denotes Th2
T16788 26863-26868 NNS denotes cells
T16789 26869-26871 IN denotes as
T16790 26872-26875 VBZ denotes has
T16791 26876-26880 VBN denotes been
T16792 26881-26889 VBN denotes reported
T16793 26890-26891 -LRB- denotes (
T16794 26891-26896 NNP denotes Chang
T16795 26897-26899 FW denotes et
T16796 26900-26903 FW denotes al.
T16797 26903-26904 , denotes ,
T16798 26905-26909 CD denotes 2007
T16799 26909-26910 : denotes ;
T16800 26911-26915 NNP denotes Wang
T16801 26916-26918 FW denotes et
T16802 26919-26922 FW denotes al.
T16803 26922-26923 , denotes ,
T16804 26924-26928 CD denotes 2005
T16805 26928-26929 -RRB- denotes )
T16806 26929-26930 , denotes ,
T16807 26931-26935 DT denotes some
T16808 26936-26943 NNS denotes studies
T16809 26944-26951 VBP denotes suggest
T16810 26952-26955 DT denotes the
T16811 26956-26965 NN denotes existence
T16812 26966-26968 IN denotes of
T16813 26969-26975 JJ denotes common
T16814 26976-26984 NNS denotes pathways
T16815 26984-26985 , denotes ,
T16816 26986-26989 CC denotes but
T16817 26990-26993 DT denotes the
T16818 26994-27003 JJ denotes molecular
T16819 27004-27009 NN denotes basis
T16820 27010-27013 IN denotes for
T16821 27014-27019 DT denotes these
T16822 27020-27022 VBZ denotes is
T16823 27023-27025 RB denotes as
T16824 27026-27029 RB denotes yet
T16825 27030-27037 JJ denotes unclear
T16826 27037-27038 . denotes .
T16827 27039-27052 NNP denotes Costimulatory
T16828 27053-27058 NNP denotes OX-40
T16829 27059-27066 NNS denotes signals
T16830 27067-27071 VBP denotes have
T16831 27072-27076 VBN denotes been
T16832 27077-27082 VBN denotes shown
T16833 27083-27085 TO denotes to
T16834 27086-27096 RB denotes negatively
T16835 27097-27105 VB denotes regulate
T16836 27106-27111 JJ denotes IL-10
T16837 27112-27122 NN denotes production
T16838 27123-27124 -LRB- denotes (
T16839 27124-27127 NNP denotes Ito
T16840 27128-27130 FW denotes et
T16841 27131-27134 FW denotes al.
T16842 27134-27135 , denotes ,
T16843 27136-27140 CD denotes 2005
T16844 27140-27141 -RRB- denotes )
T16845 27142-27146 DT denotes both
T16846 27147-27149 IN denotes in
T16847 27150-27153 NNP denotes Th1
T16848 27154-27157 CC denotes and
T16849 27158-27161 NNP denotes Th2
T16850 27162-27167 NNS denotes cells
T16851 27167-27168 , denotes ,
T16852 27169-27176 IN denotes whereas
T16853 27177-27181 NNP denotes ICOS
T16854 27182-27191 VBG denotes signaling
T16855 27192-27195 VBZ denotes has
T16856 27196-27200 VBN denotes been
T16857 27201-27210 VBN denotes suggested
T16858 27211-27213 TO denotes to
T16859 27214-27220 VB denotes induce
T16860 27221-27226 NNP denotes IL-10
T16861 27227-27228 -LRB- denotes (
T16862 27228-27231 NNP denotes Ito
T16863 27232-27234 FW denotes et
T16864 27235-27238 FW denotes al.
T16865 27238-27239 , denotes ,
T16866 27240-27244 CD denotes 2007
T16867 27244-27245 : denotes ;
T16868 27246-27252 NNP denotes Witsch
T16869 27253-27255 FW denotes et
T16870 27256-27259 FW denotes al.
T16871 27259-27260 , denotes ,
T16872 27261-27265 CD denotes 2002
T16873 27265-27266 -RRB- denotes )
T16874 27267-27269 IN denotes in
T16875 27270-27274 DT denotes both
T16876 27275-27278 CD denotes Th1
T16877 27279-27282 CC denotes and
T16878 27283-27286 CD denotes Th2
T16879 27287-27292 NNS denotes cells
T16880 27292-27293 . denotes .
T16881 27294-27301 RB denotes However
T16882 27301-27302 , denotes ,
T16883 27303-27305 IN denotes in
T16884 27306-27310 DT denotes some
T16885 27311-27316 NNS denotes cases
T16886 27316-27317 , denotes ,
T16887 27318-27322 NNP denotes ICOS
T16888 27323-27332 VBG denotes signaling
T16889 27333-27337 RB denotes also
T16890 27338-27347 VBZ denotes regulates
T16891 27348-27352 NN denotes IL-4
T16892 27353-27363 NN denotes production
T16893 27364-27367 CC denotes and
T16894 27368-27371 JJ denotes Th2
T16895 27372-27381 NNS denotes responses
T16896 27382-27383 -LRB- denotes (
T16897 27383-27392 NNP denotes Greenwald
T16898 27393-27395 FW denotes et
T16899 27396-27399 FW denotes al.
T16900 27399-27400 , denotes ,
T16901 27401-27405 CD denotes 2005
T16902 27405-27406 -RRB- denotes )
T16903 27406-27407 . denotes .
T16904 27408-27410 PRP denotes We
T16905 27411-27414 RB denotes now
T16906 27415-27422 VBP denotes provide
T16907 27423-27424 DT denotes a
T16908 27425-27431 JJ denotes common
T16909 27432-27441 NN denotes mechanism
T16910 27442-27444 IN denotes of
T16911 27445-27449 CD denotes ERK1
T16912 27450-27453 CC denotes and
T16913 27454-27458 CD denotes ERK2
T16914 27459-27469 NN denotes activation
T16915 27470-27473 IN denotes for
T16916 27474-27477 DT denotes the
T16917 27478-27488 NN denotes regulation
T16918 27489-27491 IN denotes of
T16919 27492-27497 JJ denotes IL-10
T16920 27498-27508 NN denotes production
T16921 27509-27511 IN denotes in
T16922 27512-27515 NNP denotes Th1
T16923 27515-27516 , denotes ,
T16924 27517-27520 NNP denotes Th2
T16925 27520-27521 , denotes ,
T16926 27522-27525 CC denotes and
T16927 27526-27530 NNP denotes Th17
T16928 27531-27536 NNS denotes cells
T16929 27536-27537 , denotes ,
T16930 27538-27546 IN denotes although
T16931 27547-27551 DT denotes each
T16932 27552-27558 NN denotes subset
T16933 27559-27573 VBZ denotes differentiates
T16934 27574-27579 IN denotes along
T16935 27580-27581 DT denotes a
T16936 27582-27590 JJ denotes distinct
T16937 27591-27594 CC denotes and
T16938 27595-27610 JJ denotes subset-specific
T16939 27611-27626 JJ denotes transcriptional
T16940 27627-27634 NN denotes pathway
T16941 27634-27635 . denotes .
T16942 27636-27640 DT denotes This
T16943 27641-27651 VBZ denotes reinforces
T16944 27652-27655 DT denotes the
T16945 27656-27660 NN denotes fact
T16946 27661-27665 IN denotes that
T16947 27666-27671 NNP denotes IL-10
T16948 27672-27674 VBZ denotes is
T16949 27675-27678 RB denotes not
T16950 27679-27680 DT denotes a
T16951 27681-27683 NNP denotes Th
T16952 27684-27704 JJ denotes cell-subset-specific
T16953 27705-27713 NN denotes cytokine
T16954 27713-27714 , denotes ,
T16955 27715-27718 CC denotes but
T16956 27719-27726 RB denotes instead
T16957 27727-27729 VBZ denotes is
T16958 27730-27738 VBN denotes produced
T16959 27739-27741 IN denotes in
T16960 27742-27743 DT denotes a
T16961 27744-27751 RB denotes tightly
T16962 27752-27761 VBN denotes regulated
T16963 27762-27769 NN denotes fashion
T16964 27770-27776 IN denotes during
T16965 27777-27781 DT denotes each
T16966 27782-27797 NN denotes differentiation
T16967 27798-27805 NN denotes pathway
T16968 27805-27806 . denotes .
T16969 27807-27809 IN denotes Of
T16970 27810-27814 NN denotes note
T16971 27814-27815 , denotes ,
T16972 27816-27817 DT denotes a
T16973 27818-27822 NN denotes role
T16974 27823-27826 IN denotes for
T16975 27827-27831 CD denotes ERK1
T16976 27832-27835 CC denotes and
T16977 27836-27840 CD denotes ERK2
T16978 27841-27851 NN denotes activation
T16979 27852-27854 IN denotes in
T16980 27855-27858 DT denotes the
T16981 27859-27868 NN denotes induction
T16982 27869-27871 IN denotes of
T16983 27872-27877 JJ denotes IL-10
T16984 27878-27888 NN denotes production
T16985 27889-27892 VBZ denotes has
T16986 27893-27900 RB denotes already
T16987 27901-27905 VBN denotes been
T16988 27906-27915 VBN denotes described
T16989 27916-27919 IN denotes for
T16990 27920-27931 NNS denotes macrophages
T16991 27932-27935 CC denotes and
T16992 27936-27938 NNP denotes DC
T16993 27939-27940 -LRB- denotes (
T16994 27940-27947 NNP denotes Agrawal
T16995 27948-27950 FW denotes et
T16996 27951-27954 FW denotes al.
T16997 27954-27955 , denotes ,
T16998 27956-27960 CD denotes 2006
T16999 27960-27961 : denotes ;
T17000 27962-27968 NNP denotes Hacker
T17001 27969-27971 FW denotes et
T17002 27972-27975 FW denotes al.
T17003 27975-27976 , denotes ,
T17004 27977-27981 CD denotes 1999
T17005 27981-27982 -RRB- denotes )
T17006 27982-27983 . denotes .
T17007 27984-27996 NNP denotes Differential
T17008 27997-28012 JJ denotes transcriptional
T17009 28013-28023 NN denotes regulation
T17010 28024-28026 IN denotes of
T17011 28027-28032 NNP denotes IL-10
T17012 28033-28035 IN denotes in
T17013 28036-28039 NNP denotes Th1
T17014 28040-28043 CC denotes and
T17015 28044-28047 NNP denotes Th2
T17016 28048-28053 NNS denotes cells
T17017 28054-28057 VBZ denotes has
T17018 28058-28062 VBN denotes been
T17019 28063-28072 VBN denotes suggested
T17020 28073-28074 -LRB- denotes (
T17021 28074-28079 NNP denotes Chang
T17022 28080-28082 FW denotes et
T17023 28083-28086 FW denotes al.
T17024 28086-28087 , denotes ,
T17025 28088-28092 CD denotes 2007
T17026 28092-28093 : denotes ;
T17027 28094-28098 NNP denotes Wang
T17028 28099-28101 FW denotes et
T17029 28102-28105 FW denotes al.
T17030 28105-28106 , denotes ,
T17031 28107-28111 CD denotes 2005
T17032 28111-28112 -RRB- denotes )
T17033 28112-28113 , denotes ,
T17034 28114-28117 CC denotes and
T17035 28118-28127 JJ denotes extensive
T17036 28128-28135 NN denotes histone
T17037 28136-28147 NN denotes acetylation
T17038 28148-28150 IN denotes of
T17039 28151-28154 DT denotes the
T17040 28155-28160 NNP denotes IL-10
T17041 28161-28165 NN denotes gene
T17042 28166-28168 VBZ denotes is
T17043 28169-28179 JJ denotes detectable
T17044 28180-28182 IN denotes in
T17045 28183-28188 RB denotes fully
T17046 28189-28198 VBN denotes polarized
T17047 28199-28202 JJ denotes Th2
T17048 28203-28208 NNS denotes cells
T17049 28208-28209 , denotes ,
T17050 28210-28213 CC denotes but
T17051 28214-28217 RB denotes not
T17052 28218-28221 JJ denotes Th1
T17053 28222-28227 NNS denotes cells
T17054 28228-28229 -LRB- denotes (
T17055 28229-28234 NNP denotes Chang
T17056 28235-28237 FW denotes et
T17057 28238-28241 FW denotes al.
T17058 28241-28242 , denotes ,
T17059 28243-28247 CD denotes 2007
T17060 28247-28248 -RRB- denotes )
T17061 28248-28249 . denotes .
T17062 28250-28252 PRP denotes We
T17063 28253-28260 VBP denotes provide
T17064 28261-28269 NN denotes evidence
T17065 28270-28274 IN denotes that
T17066 28275-28280 NNP denotes IL-10
T17067 28281-28283 VBZ denotes is
T17068 28284-28292 VBN denotes produced
T17069 28293-28295 IN denotes in
T17070 28296-28305 JJ denotes canonical
T17071 28306-28309 JJ denotes Th1
T17072 28310-28315 NNS denotes cells
T17073 28316-28319 CC denotes and
T17074 28320-28324 IN denotes that
T17075 28325-28328 PRP$ denotes its
T17076 28329-28339 NN denotes expression
T17077 28340-28350 VBZ denotes correlates
T17078 28351-28355 IN denotes with
T17079 28356-28359 DT denotes the
T17080 28360-28370 NN denotes expression
T17081 28371-28373 IN denotes of
T17082 28374-28379 NN denotes T-bet
T17083 28380-28383 CC denotes and
T17084 28384-28387 DT denotes the
T17085 28388-28395 JJS denotes highest
T17086 28396-28401 JJ denotes IFN-γ
T17087 28402-28412 NN denotes production
T17088 28412-28413 , denotes ,
T17089 28414-28416 IN denotes in
T17090 28417-28424 VBG denotes keeping
T17091 28425-28429 IN denotes with
T17092 28430-28433 PRP$ denotes our
T17093 28434-28446 NNS denotes observations
T17094 28447-28451 IN denotes that
T17095 28452-28461 JJ denotes high-dose
T17096 28462-28469 NN denotes antigen
T17097 28470-28481 NN denotes stimulation
T17098 28482-28485 CC denotes and
T17099 28486-28491 NN denotes IL-12
T17100 28492-28501 VBG denotes signaling
T17101 28502-28505 VBP denotes are
T17102 28506-28514 VBN denotes required
T17103 28515-28518 IN denotes for
T17104 28519-28524 NNP denotes IL-10
T17105 28525-28528 CC denotes and
T17106 28529-28534 NNP denotes IFN-γ
T17107 28535-28545 NN denotes expression
T17108 28545-28546 . denotes .
T17109 28547-28549 PRP denotes It
T17110 28550-28553 VBZ denotes has
T17111 28554-28558 RB denotes also
T17112 28559-28563 VBN denotes been
T17113 28564-28569 VBN denotes shown
T17114 28570-28574 IN denotes that
T17115 28575-28586 NN denotes maintenance
T17116 28587-28589 IN denotes of
T17117 28590-28595 NNP denotes IL-10
T17118 28596-28606 NN denotes expression
T17119 28607-28609 VBZ denotes is
T17120 28610-28621 JJ denotes conditional
T17121 28622-28624 IN denotes on
T17122 28625-28630 NN denotes IL-12
T17123 28631-28633 CC denotes or
T17124 28634-28638 NN denotes IL-4
T17125 28639-28645 IN denotes unless
T17126 28646-28649 DT denotes the
T17127 28650-28655 NNP denotes IL-10
T17128 28656-28660 NN denotes gene
T17129 28661-28663 VBZ denotes is
T17130 28664-28673 VBN denotes imprinted
T17131 28674-28676 IN denotes by
T17132 28677-28683 NNP denotes GATA-3
T17133 28684-28685 -LRB- denotes (
T17134 28685-28690 NNP denotes Chang
T17135 28691-28693 FW denotes et
T17136 28694-28697 FW denotes al.
T17137 28697-28698 , denotes ,
T17138 28699-28703 CD denotes 2007
T17139 28703-28704 -RRB- denotes )
T17140 28704-28705 , denotes ,
T17141 28706-28711 WDT denotes which
T17142 28712-28715 MD denotes can
T17143 28716-28723 VB denotes remodel
T17144 28724-28727 DT denotes the
T17145 28728-28733 NN denotes IL-10
T17146 28734-28739 NN denotes locus
T17147 28739-28740 , denotes ,
T17148 28741-28745 RB denotes thus
T17149 28746-28756 VBG denotes explaining
T17150 28757-28760 DT denotes the
T17151 28761-28768 JJS denotes highest
T17152 28769-28776 NNS denotes amounts
T17153 28777-28779 IN denotes of
T17154 28780-28785 NN denotes IL-10
T17155 28786-28794 VBN denotes produced
T17156 28795-28797 IN denotes by
T17157 28798-28801 JJ denotes Th2
T17158 28802-28807 NNS denotes cells
T17159 28808-28809 -LRB- denotes (
T17160 28809-28814 NNP denotes Chang
T17161 28815-28817 FW denotes et
T17162 28818-28821 FW denotes al.
T17163 28821-28822 , denotes ,
T17164 28823-28827 CD denotes 2007
T17165 28827-28828 : denotes ;
T17166 28829-28838 NNP denotes Shoemaker
T17167 28839-28841 FW denotes et
T17168 28842-28845 FW denotes al.
T17169 28845-28846 , denotes ,
T17170 28847-28851 CD denotes 2006
T17171 28851-28852 -RRB- denotes )
T17172 28852-28853 . denotes .
T17173 28854-28856 PRP denotes We
T17174 28857-28861 VBP denotes show
T17175 28862-28866 RB denotes here
T17176 28867-28871 DT denotes that
T17177 28872-28876 JJ denotes high
T17178 28877-28884 NN denotes antigen
T17179 28885-28889 NN denotes dose
T17180 28890-28893 CC denotes and
T17181 28894-28899 NN denotes IL-12
T17182 28900-28911 RB denotes drastically
T17183 28912-28924 VBP denotes downregulate
T17184 28925-28931 JJ denotes Gata-3
T17185 28932-28942 NN denotes expression
T17186 28942-28943 , denotes ,
T17187 28944-28954 VBG denotes suggesting
T17188 28955-28959 IN denotes that
T17189 28960-28970 JJ denotes additional
T17190 28971-28978 NNS denotes factors
T17191 28979-28982 VBP denotes are
T17192 28983-28985 IN denotes in
T17193 28986-28991 NN denotes place
T17194 28992-28994 TO denotes to
T17195 28995-29001 VB denotes induce
T17196 29002-29007 JJ denotes IL-10
T17197 29008-29018 NN denotes expression
T17198 29019-29021 IN denotes in
T17199 29022-29025 JJ denotes Th1
T17200 29026-29031 NNS denotes cells
T17201 29031-29032 , denotes ,
T17202 29033-29039 IN denotes albeit
T17203 29040-29051 RB denotes transiently
T17204 29051-29052 . denotes .
T17205 29053-29063 NN denotes Expression
T17206 29064-29066 IN denotes of
T17207 29067-29072 NN denotes c-maf
T17208 29073-29076 VBD denotes was
T17209 29077-29084 RB denotes greatly
T17210 29085-29095 VBN denotes diminished
T17211 29096-29098 IN denotes by
T17212 29099-29103 JJ denotes high
T17213 29104-29111 NN denotes antigen
T17214 29112-29117 NNS denotes doses
T17215 29118-29120 IN denotes in
T17216 29121-29122 NNP denotes T
T17217 29123-29128 NNS denotes cells
T17218 29129-29132 CC denotes and
T17219 29133-29136 RB denotes yet
T17220 29137-29140 VBD denotes was
T17221 29141-29153 RB denotes unexpectedly
T17222 29154-29164 VBN denotes maintained
T17223 29165-29167 IN denotes by
T17224 29168-29173 NNP denotes IL-12
T17225 29174-29177 CC denotes and
T17226 29178-29185 JJ denotes present
T17227 29186-29188 IN denotes in
T17228 29189-29193 NNP denotes Th17
T17229 29194-29199 NNS denotes cells
T17230 29199-29200 . denotes .
T17231 29201-29205 DT denotes That
T17232 29206-29211 JJ denotes c-maf
T17233 29212-29222 NN denotes expression
T17234 29223-29225 VBZ denotes is
T17235 29226-29232 JJ denotes common
T17236 29233-29235 TO denotes to
T17237 29236-29251 JJ denotes IL-10-producing
T17238 29252-29255 NNP denotes Th1
T17239 29255-29256 , denotes ,
T17240 29257-29260 NNP denotes Th2
T17241 29260-29261 , denotes ,
T17242 29262-29265 CC denotes and
T17243 29266-29270 NNP denotes Th17
T17244 29271-29276 NNS denotes cells
T17245 29277-29280 CC denotes and
T17246 29280-29281 , denotes ,
T17247 29282-29286 IN denotes like
T17248 29287-29292 NNP denotes IL-10
T17249 29292-29293 , denotes ,
T17250 29294-29296 VBZ denotes is
T17251 29297-29306 JJ denotes dependent
T17252 29307-29309 IN denotes on
T17253 29310-29313 NNP denotes ERK
T17254 29314-29324 NN denotes activation
T17255 29325-29327 IN denotes in
T17256 29328-29331 NNP denotes Th1
T17257 29332-29335 CC denotes and
T17258 29336-29340 NNP denotes Th17
T17259 29341-29346 NNS denotes cells
T17260 29347-29350 IN denotes for
T17261 29351-29354 PRP$ denotes its
T17262 29355-29365 NN denotes expression
T17263 29366-29368 VBZ denotes is
T17264 29369-29371 IN denotes of
T17265 29372-29380 NN denotes interest
T17266 29381-29388 IN denotes because
T17267 29389-29394 NNP denotes c-Maf
T17268 29395-29398 VBZ denotes has
T17269 29399-29403 VBN denotes been
T17270 29404-29409 VBN denotes shown
T17271 29410-29412 TO denotes to
T17272 29413-29415 VB denotes be
T17273 29416-29418 DT denotes an
T17274 29419-29428 JJ denotes essential
T17275 29429-29442 NN denotes transcription
T17276 29443-29449 NN denotes factor
T17277 29450-29453 IN denotes for
T17278 29454-29459 NNP denotes IL-10
T17279 29460-29470 NN denotes expression
T17280 29471-29473 IN denotes in
T17281 29474-29485 NNS denotes macrophages
T17282 29486-29487 -LRB- denotes (
T17283 29487-29490 NNP denotes Cao
T17284 29491-29493 FW denotes et
T17285 29494-29497 FW denotes al.
T17286 29497-29498 , denotes ,
T17287 29499-29503 CD denotes 2005
T17288 29503-29504 -RRB- denotes )
T17289 29504-29505 . denotes .
T17290 29506-29508 IN denotes In
T17291 29509-29516 NN denotes summary
T17292 29516-29517 , denotes ,
T17293 29518-29520 PRP denotes we
T17294 29521-29525 VBP denotes show
T17295 29526-29530 IN denotes that
T17296 29531-29539 IN denotes although
T17297 29540-29543 NNP denotes Th1
T17298 29543-29544 , denotes ,
T17299 29545-29548 NNP denotes Th2
T17300 29548-29549 , denotes ,
T17301 29550-29553 CC denotes and
T17302 29554-29558 NNP denotes Th17
T17303 29559-29562 NNP denotes CD4
T17304 29562-29563 VBD denotes +
T17305 29564-29565 NNP denotes T
T17306 29566-29570 NN denotes cell
T17307 29571-29578 VBZ denotes subsets
T17308 29579-29592 NN denotes differentiate
T17309 29593-29598 IN denotes along
T17310 29599-29607 JJ denotes distinct
T17311 29608-29617 VBG denotes signaling
T17312 29618-29621 CC denotes and
T17313 29622-29637 JJ denotes transcriptional
T17314 29638-29646 NNS denotes pathways
T17315 29646-29647 , denotes ,
T17316 29648-29652 PRP denotes they
T17317 29653-29656 MD denotes can
T17318 29657-29660 RB denotes all
T17319 29661-29663 VB denotes be
T17320 29664-29671 VBN denotes induced
T17321 29672-29674 TO denotes to
T17322 29675-29679 VB denotes make
T17323 29680-29685 NN denotes IL-10
T17324 29685-29686 . denotes .
T17325 29687-29691 CD denotes ERK1
T17326 29692-29695 CC denotes and
T17327 29696-29700 CD denotes ERK2
T17328 29701-29711 NN denotes activation
T17329 29712-29714 VBZ denotes is
T17330 29715-29723 VBN denotes required
T17331 29724-29727 IN denotes for
T17332 29728-29733 JJ denotes IL-10
T17333 29734-29744 NN denotes production
T17334 29745-29747 IN denotes by
T17335 29748-29751 DT denotes all
T17336 29752-29757 DT denotes these
T17337 29758-29760 NNP denotes Th
T17338 29761-29765 NN denotes cell
T17339 29766-29773 NNS denotes subsets
T17340 29773-29774 . denotes .
T17341 29775-29779 IN denotes With
T17342 29780-29786 NN denotes regard
T17343 29787-29789 TO denotes to
T17344 29790-29793 DT denotes the
T17345 29794-29804 NN denotes expression
T17346 29805-29807 IN denotes of
T17347 29808-29813 NN denotes IL-10
T17348 29814-29816 IN denotes by
T17349 29817-29820 JJ denotes Th1
T17350 29821-29826 NNS denotes cells
T17351 29826-29827 , denotes ,
T17352 29828-29831 PRP$ denotes our
T17353 29832-29836 NNS denotes data
T17354 29837-29844 VBP denotes provide
T17355 29845-29846 DT denotes a
T17356 29847-29856 NN denotes mechanism
T17357 29857-29860 IN denotes for
T17358 29861-29864 WRB denotes how
T17359 29865-29870 JJ denotes IL-10
T17360 29871-29881 NN denotes expression
T17361 29882-29884 VBZ denotes is
T17362 29885-29892 JJ denotes induced
T17363 29893-29896 CC denotes and
T17364 29897-29901 RB denotes then
T17365 29902-29911 VBD denotes amplified
T17366 29912-29915 CC denotes and
T17367 29916-29925 VBN denotes regulated
T17368 29926-29928 IN denotes by
T17369 29929-29932 DT denotes the
T17370 29933-29939 NNS denotes levels
T17371 29940-29942 IN denotes of
T17372 29943-29950 NN denotes antigen
T17373 29951-29954 CC denotes and
T17374 29955-29960 NN denotes IL-12
T17375 29961-29972 VBN denotes encountered
T17376 29973-29975 IN denotes in
T17377 29976-29979 DT denotes the
T17378 29980-29991 NN denotes environment
T17379 29991-29992 . denotes .
T17380 29993-29997 DT denotes This
T17381 29998-30006 VBZ denotes provides
T17382 30007-30008 DT denotes a
T17383 30009-30018 NN denotes mechanism
T17384 30019-30026 WRB denotes whereby
T17385 30027-30028 DT denotes a
T17386 30029-30032 JJ denotes Th1
T17387 30033-30037 NN denotes cell
T17388 30038-30046 VBZ denotes responds
T17389 30047-30049 TO denotes to
T17390 30050-30059 JJ denotes extrinsic
T17391 30060-30067 NNS denotes signals
T17392 30067-30068 , denotes ,
T17393 30069-30079 VBG denotes reflecting
T17394 30080-30089 VBN denotes increased
T17395 30090-30102 NN denotes inflammation
T17396 30103-30105 IN denotes in
T17397 30106-30109 DT denotes the
T17398 30110-30116 NN denotes tissue
T17399 30116-30117 , denotes ,
T17400 30118-30120 TO denotes to
T17401 30121-30128 RB denotes tightly
T17402 30129-30137 VB denotes regulate
T17403 30138-30141 DT denotes the
T17404 30142-30152 NN denotes production
T17405 30153-30155 IN denotes of
T17406 30156-30161 NNP denotes IL-10
T17407 30162-30164 RB denotes so
T17408 30165-30167 IN denotes as
T17409 30168-30170 TO denotes to
T17410 30171-30176 VB denotes allow
T17411 30177-30178 DT denotes a
T17412 30179-30189 JJ denotes protective
T17413 30190-30198 NN denotes response
T17414 30199-30201 TO denotes to
T17415 30202-30211 VB denotes eradicate
T17416 30212-30213 DT denotes a
T17417 30214-30222 NN denotes pathogen
T17418 30223-30227 IN denotes with
T17419 30228-30235 JJ denotes minimal
T17420 30236-30242 NN denotes damage
T17421 30243-30245 TO denotes to
T17422 30246-30249 DT denotes the
T17423 30250-30254 NN denotes host
T17424 30255-30258 CC denotes and
T17425 30259-30263 RB denotes also
T17426 30264-30271 VBP denotes prevent
T17427 30272-30279 JJ denotes chronic
T17428 30280-30289 NN denotes infection
T17429 30289-30290 . denotes .
T17430 30291-30299 RB denotes Moreover
T17431 30299-30300 , denotes ,
T17432 30301-30304 PRP$ denotes our
T17433 30305-30313 NNS denotes findings
T17434 30314-30318 VBP denotes have
T17435 30319-30328 JJ denotes important
T17436 30329-30341 NNS denotes implications
T17437 30342-30345 IN denotes for
T17438 30346-30349 DT denotes the
T17439 30350-30360 NN denotes regulation
T17440 30361-30363 IN denotes of
T17441 30364-30369 JJ denotes IL-10
T17442 30370-30380 NN denotes production
T17443 30381-30387 IN denotes during
T17444 30388-30390 DT denotes an
T17445 30391-30403 JJ denotes inflammatory
T17446 30404-30407 JJ denotes Th1
T17447 30408-30416 NN denotes response
T17448 30417-30419 IN denotes in
T17449 30420-30429 NN denotes infection
T17450 30430-30433 CC denotes and
T17451 30434-30437 MD denotes may
T17452 30438-30440 VB denotes be
T17453 30441-30443 IN denotes of
T17454 30444-30453 NN denotes relevance
T17455 30454-30457 IN denotes for
T17456 30458-30461 DT denotes the
T17457 30462-30468 NN denotes design
T17458 30469-30471 IN denotes of
T17459 30472-30480 NNS denotes vaccines
T17460 30481-30484 CC denotes and
T17461 30485-30488 IN denotes for
T17462 30489-30499 NNS denotes strategies
T17463 30500-30502 IN denotes in
T17464 30503-30516 JJ denotes immunotherapy
T17465 30517-30519 IN denotes in
T17466 30520-30530 JJ denotes infectious
T17467 30531-30539 NNS denotes diseases
T17468 30539-30540 . denotes .
T18710 30567-30571 NNP denotes Mice
T18711 30571-30572 , denotes ,
T18712 30573-30582 NNP denotes Cytokines
T18713 30582-30583 , denotes ,
T18714 30584-30594 NNP denotes Antibodies
T18715 30594-30595 , denotes ,
T18716 30596-30599 CC denotes and
T18717 30600-30605 JJ denotes Other
T18718 30606-30614 NNP denotes Reagents
T18719 30615-30621 NNP denotes BALB/c
T18720 30622-30626 NNP denotes DO11
T18721 30626-30629 CD denotes .10
T18722 30630-30634 NNS denotes mice
T18723 30635-30645 JJ denotes transgenic
T18724 30646-30649 IN denotes for
T18725 30650-30662 JJ denotes OVA-specific
T18726 30663-30666 NNP denotes TCR
T18727 30667-30669 NNP denotes WT
T18728 30670-30672 CC denotes or
T18729 30673-30680 VBD denotes crossed
T18730 30681-30685 RP denotes back
T18731 30686-30690 IN denotes with
T18732 30691-30695 NNP denotes Rag1
T18733 30695-30696 : denotes -
T18734 30696-30697 , denotes ,
T18735 30698-30702 NN denotes IL-4
T18736 30702-30703 : denotes -
T18737 30703-30704 , denotes ,
T18738 30705-30710 NNP denotes IFN-γ
T18739 30710-30711 : denotes -
T18740 30711-30712 , denotes ,
T18741 30713-30718 NNP denotes STAT4
T18742 30718-30719 : denotes -
T18743 30719-30720 , denotes ,
T18744 30721-30724 CC denotes and
T18745 30725-30740 JJ denotes STAT6-deficient
T18746 30741-30745 NNS denotes mice
T18747 30746-30750 VBD denotes were
T18748 30751-30755 VBN denotes used
T18749 30756-30758 IN denotes as
T18750 30759-30760 DT denotes a
T18751 30761-30767 NN denotes source
T18752 30768-30770 IN denotes of
T18753 30771-30787 JJ denotes antigen-specific
T18754 30788-30789 NNP denotes T
T18755 30790-30795 NNS denotes cells
T18756 30796-30797 -LRB- denotes (
T18757 30797-30803 NNP denotes Murphy
T18758 30804-30806 FW denotes et
T18759 30807-30810 FW denotes al.
T18760 30810-30811 , denotes ,
T18761 30812-30816 CD denotes 1990
T18762 30816-30817 : denotes ;
T18763 30818-30824 NNP denotes Ouyang
T18764 30825-30827 FW denotes et
T18765 30828-30831 FW denotes al.
T18766 30831-30832 , denotes ,
T18767 30833-30837 CD denotes 1998
T18768 30837-30838 : denotes ;
T18769 30839-30848 NNP denotes Shoemaker
T18770 30849-30851 FW denotes et
T18771 30852-30855 FW denotes al.
T18772 30855-30856 , denotes ,
T18773 30857-30861 CD denotes 2006
T18774 30861-30862 -RRB- denotes )
T18775 30863-30866 CC denotes and
T18776 30867-30871 VBD denotes were
T18777 30872-30876 VBN denotes bred
T18778 30877-30880 CC denotes and
T18779 30881-30891 VBN denotes maintained
T18780 30892-30897 IN denotes under
T18781 30898-30901 NNP denotes SPF
T18782 30902-30912 NNS denotes conditions
T18783 30913-30915 IN denotes at
T18784 30916-30919 DT denotes the
T18785 30920-30924 NNP denotes NIMR
T18786 30924-30925 , denotes ,
T18787 30926-30932 NNP denotes London
T18788 30932-30933 , denotes ,
T18789 30934-30938 NNP denotes Home
T18790 30939-30945 NNP denotes Office
T18791 30945-30946 , denotes ,
T18792 30947-30949 NNP denotes UK
T18793 30949-30950 , denotes ,
T18794 30951-30958 NNS denotes Animals
T18795 30959-30960 -LRB- denotes (
T18796 30960-30970 NNP denotes Scientific
T18797 30971-30981 NNPS denotes Procedures
T18798 30981-30982 -RRB- denotes )
T18799 30983-30986 NNP denotes Act
T18800 30987-30991 CD denotes 1986
T18801 30992-30994 CC denotes or
T18802 30995-30997 IN denotes at
T18803 30998-31001 DT denotes the
T18804 31002-31012 NNP denotes Washington
T18805 31013-31023 NNP denotes University
T18806 31024-31030 NNP denotes School
T18807 31031-31033 IN denotes of
T18808 31034-31042 NNP denotes Medicine
T18809 31042-31043 . denotes .
T18810 31044-31050 JJ denotes Female
T18811 31051-31055 NNS denotes mice
T18812 31056-31060 VBD denotes were
T18813 31061-31065 VBN denotes used
T18814 31066-31068 IN denotes at
T18815 31069-31070 CD denotes 8
T18816 31071-31073 CD denotes 12
T18817 31074-31079 NNS denotes weeks
T18818 31080-31083 JJ denotes old
T18819 31083-31084 , denotes ,
T18820 31085-31088 CC denotes and
T18821 31089-31095 NN denotes animal
T18822 31096-31105 NNS denotes protocols
T18823 31106-31110 VBD denotes were
T18824 31111-31119 VBN denotes approved
T18825 31120-31129 VBG denotes according
T18826 31130-31132 TO denotes to
T18827 31133-31136 DT denotes the
T18828 31137-31144 NNS denotes Animals
T18829 31145-31146 -LRB- denotes (
T18830 31146-31156 NNP denotes Scientific
T18831 31157-31167 NNPS denotes Procedures
T18832 31167-31168 -RRB- denotes )
T18833 31169-31172 NNP denotes Act
T18834 31173-31177 CD denotes 1986
T18835 31177-31178 , denotes ,
T18836 31179-31183 NNP denotes Home
T18837 31184-31190 NNP denotes Office
T18838 31190-31191 , denotes ,
T18839 31192-31194 NNP denotes UK
T18840 31194-31195 . denotes .
T18841 31196-31204 NNS denotes Reagents
T18842 31204-31205 , denotes ,
T18843 31206-31215 VBG denotes including
T18844 31216-31226 NNS denotes antibodies
T18845 31227-31230 IN denotes for
T18846 31231-31232 NNP denotes T
T18847 31233-31237 NN denotes cell
T18848 31238-31241 CC denotes and
T18849 31242-31244 NNP denotes DC
T18850 31245-31256 NN denotes preparation
T18851 31256-31257 , denotes ,
T18852 31258-31270 NN denotes purification
T18853 31271-31274 CC denotes and
T18854 31275-31282 NN denotes culture
T18855 31282-31283 , denotes ,
T18856 31284-31289 NNS denotes media
T18857 31289-31290 , denotes ,
T18858 31291-31300 NNS denotes cytokines
T18859 31300-31301 , denotes ,
T18860 31302-31305 CC denotes and
T18861 31306-31314 NN denotes cytokine
T18862 31315-31319 NNS denotes mAbs
T18863 31320-31324 VBP denotes have
T18864 31325-31329 VBN denotes been
T18865 31330-31339 VBN denotes described
T18866 31340-31341 -LRB- denotes (
T18867 31341-31347 NNP denotes Hosken
T18868 31348-31350 FW denotes et
T18869 31351-31354 FW denotes al.
T18870 31354-31355 , denotes ,
T18871 31356-31360 CD denotes 1995
T18872 31360-31361 : denotes ;
T18873 31362-31371 NNP denotes Shoemaker
T18874 31372-31374 FW denotes et
T18875 31375-31378 FW denotes al.
T18876 31378-31379 , denotes ,
T18877 31380-31384 CD denotes 2006
T18878 31384-31385 : denotes ;
T18879 31386-31394 NNP denotes Veldhoen
T18880 31395-31397 FW denotes et
T18881 31398-31401 FW denotes al.
T18882 31401-31402 , denotes ,
T18883 31403-31407 CD denotes 2009
T18884 31407-31408 : denotes ;
T18885 31409-31417 NNP denotes Veldhoen
T18886 31418-31420 FW denotes et
T18887 31421-31424 FW denotes al.
T18888 31424-31425 , denotes ,
T18889 31426-31430 CD denotes 2006
T18890 31430-31431 -RRB- denotes )
T18891 31431-31432 . denotes .
T18892 31433-31436 NNP denotes LPS
T18893 31437-31438 -LRB- denotes (
T18894 31438-31440 NNP denotes S.
T18895 31441-31450 NN denotes minnesota
T18896 31450-31451 -RRB- denotes )
T18897 31452-31455 VBD denotes was
T18898 31456-31460 IN denotes from
T18899 31461-31467 NNP denotes Alexis
T18900 31467-31468 , denotes ,
T18901 31469-31476 NN denotes chicken
T18902 31477-31486 NN denotes ovalbumin
T18903 31487-31494 NN denotes protein
T18904 31495-31496 -LRB- denotes (
T18905 31496-31499 NNP denotes OVA
T18906 31500-31507 NN denotes protein
T18907 31507-31508 -RRB- denotes )
T18908 31509-31512 VBD denotes was
T18909 31513-31517 IN denotes from
T18910 31518-31522 IN denotes from
T18911 31523-31536 NNP denotes Sigma-Aldrich
T18912 31536-31537 , denotes ,
T18913 31538-31541 CC denotes and
T18914 31542-31551 NN denotes ovalbumin
T18915 31552-31566 NN denotes peptide323-339
T18916 31567-31568 -LRB- denotes (
T18917 31568-31571 NNP denotes OVA
T18918 31571-31572 -RRB- denotes )
T18919 31573-31574 -LRB- denotes (
T18920 31574-31588 JJ denotes endotoxin-free
T18921 31588-31589 -RRB- denotes )
T18922 31590-31593 VBD denotes was
T18923 31594-31598 IN denotes from
T18924 31599-31611 NNP denotes Biosynthesis
T18925 31611-31612 . denotes .
T18926 31613-31618 CD denotes U0126
T18927 31619-31622 VBD denotes was
T18928 31623-31627 IN denotes from
T18929 31628-31634 NNP denotes BioMol
T18930 31635-31648 NNP denotes International
T18931 31648-31649 . denotes .
T18932 31650-31658 CD denotes PD184352
T18933 31659-31660 -LRB- denotes (
T18934 31660-31663 NNP denotes MEK
T18935 31664-31674 NNS denotes inhibitors
T18936 31674-31675 -RRB- denotes )
T18937 31675-31676 , denotes ,
T18938 31677-31685 NNP denotes SB203580
T18939 31686-31687 -LRB- denotes (
T18940 31687-31690 CD denotes p38
T18941 31691-31700 NN denotes inhibitor
T18942 31700-31701 -RRB- denotes )
T18943 31701-31702 , denotes ,
T18944 31703-31706 CC denotes and
T18945 31707-31714 NNP denotes CT99021
T18946 31715-31716 -LRB- denotes (
T18947 31716-31721 NNP denotes GSK3β
T18948 31722-31731 NN denotes inhibitor
T18949 31731-31732 -RRB- denotes )
T18950 31733-31737 VBD denotes were
T18951 31738-31742 JJ denotes kind
T18952 31743-31748 NNS denotes gifts
T18953 31749-31753 IN denotes from
T18954 31754-31756 NNP denotes P.
T18955 31757-31762 NNP denotes Cohen
T18956 31763-31766 CC denotes and
T18957 31767-31769 NNP denotes N.
T18958 31770-31776 NNP denotes Shpiro
T18959 31776-31777 , denotes ,
T18960 31778-31788 NNP denotes University
T18961 31789-31791 IN denotes of
T18962 31792-31798 NNP denotes Dundee
T18963 31798-31799 , denotes ,
T18964 31800-31802 NNP denotes UK
T18965 31802-31803 . denotes .
T19460 31805-31814 NN denotes Isolation
T19461 31815-31817 IN denotes of
T19462 31818-31821 CD denotes CD4
T19463 31821-31822 CD denotes +
T19464 31823-31824 NNP denotes T
T19465 31825-31830 NNPS denotes Cells
T19466 31831-31834 CC denotes and
T19467 31835-31837 IN denotes of
T19468 31838-31845 NNP denotes Splenic
T19469 31846-31848 NNP denotes DC
T19470 31849-31852 CC denotes and
T19471 31853-31857 NNP denotes Cell
T19472 31858-31865 NNP denotes Culture
T19473 31866-31869 IN denotes for
T19474 31870-31871 NNP denotes T
T19475 31872-31876 NNP denotes Cell
T19476 31877-31886 NNP denotes Phenotype
T19477 31887-31902 NNP denotes Differentiation
T19478 31903-31904 NNP denotes T
T19479 31905-31910 NNS denotes cells
T19480 31911-31915 VBD denotes were
T19481 31916-31922 VBN denotes sorted
T19482 31923-31926 IN denotes for
T19483 31927-31930 NNP denotes CD4
T19484 31930-31931 NNP denotes +
T19485 31931-31938 NNP denotes CD62Lhi
T19486 31938-31939 , denotes ,
T19487 31940-31943 NNP denotes CD4
T19488 31943-31944 NNP denotes +
T19489 31944-31955 NNP denotes CD62LhiCD25
T19490 31955-31956 NNP denotes −
T19491 31956-31957 , denotes ,
T19492 31958-31960 CC denotes or
T19493 31961-31964 CD denotes CD4
T19494 31964-31965 NN denotes +
T19495 31965-31975 NNS denotes CD44loCD25
T19496 31975-31976 VBP denotes −
T19497 31977-31979 TO denotes to
T19498 31980-31981 VB denotes >
T19499 31981-31983 CD denotes 98
T19500 31983-31984 NN denotes %
T19501 31985-31987 IN denotes on
T19502 31988-31989 DT denotes a
T19503 31990-31995 NNP denotes Moflo
T19504 31996-32005 NN denotes cytometer
T19505 32006-32007 -LRB- denotes (
T19506 32007-32017 NNP denotes Cytomation
T19507 32017-32018 -RRB- denotes )
T19508 32019-32021 IN denotes as
T19509 32022-32028 IN denotes before
T19510 32029-32030 -LRB- denotes (
T19511 32030-32039 NN denotes Shoemaker
T19512 32040-32042 FW denotes et
T19513 32043-32046 FW denotes al.
T19514 32046-32047 , denotes ,
T19515 32048-32052 CD denotes 2006
T19516 32052-32053 : denotes ;
T19517 32054-32062 NNP denotes Veldhoen
T19518 32063-32065 FW denotes et
T19519 32066-32069 FW denotes al.
T19520 32069-32070 , denotes ,
T19521 32071-32075 CD denotes 2009
T19522 32075-32076 -RRB- denotes )
T19523 32076-32077 . denotes .
T19524 32078-32080 IN denotes In
T19525 32081-32085 JJS denotes most
T19526 32086-32091 NNS denotes cases
T19527 32091-32092 , denotes ,
T19528 32093-32104 NNS denotes experiments
T19529 32105-32109 VBD denotes were
T19530 32110-32120 VBN denotes reproduced
T19531 32121-32125 IN denotes with
T19532 32126-32130 DT denotes each
T19533 32131-32135 NN denotes type
T19534 32136-32138 IN denotes of
T19535 32139-32147 VBN denotes purified
T19536 32148-32151 NNP denotes CD4
T19537 32151-32152 CD denotes +
T19538 32153-32154 NNP denotes T
T19539 32155-32159 NN denotes cell
T19540 32160-32170 NN denotes population
T19541 32171-32175 IN denotes with
T19542 32176-32183 JJ denotes similar
T19543 32184-32191 NNS denotes results
T19544 32192-32200 VBN denotes obtained
T19545 32200-32201 . denotes .
T19546 32202-32209 JJ denotes Splenic
T19547 32210-32213 NNS denotes DCs
T19548 32214-32218 VBD denotes were
T19549 32219-32227 VBN denotes prepared
T19550 32228-32230 IN denotes as
T19551 32231-32240 VBN denotes described
T19552 32241-32242 -LRB- denotes (
T19553 32242-32248 NNP denotes Hosken
T19554 32249-32251 FW denotes et
T19555 32252-32255 FW denotes al.
T19556 32255-32256 , denotes ,
T19557 32257-32261 CD denotes 1995
T19558 32261-32262 -RRB- denotes )
T19559 32262-32263 , denotes ,
T19560 32264-32267 CC denotes and
T19561 32268-32272 NN denotes sort
T19562 32273-32281 VBD denotes purified
T19563 32282-32287 JJ denotes CD11c
T19564 32287-32288 NN denotes +
T19565 32289-32294 NNS denotes cells
T19566 32295-32299 VBD denotes were
T19567 32300-32305 VBN denotes added
T19568 32306-32308 TO denotes to
T19569 32309-32312 DT denotes the
T19570 32313-32314 NNP denotes T
T19571 32315-32319 NN denotes cell
T19572 32320-32327 NN denotes culture
T19573 32327-32328 . denotes .
T19574 32329-32337 NNP denotes Purified
T19575 32338-32342 NNP denotes DO11
T19576 32342-32345 CD denotes .10
T19577 32346-32349 NNP denotes CD4
T19578 32349-32350 CD denotes +
T19579 32351-32352 NNP denotes T
T19580 32353-32358 NNS denotes cells
T19581 32359-32360 -LRB- denotes (
T19582 32360-32361 CD denotes 1
T19583 32362-32363 CD denotes ×
T19584 32364-32367 CD denotes 105
T19585 32368-32376 NN denotes cells/ml
T19586 32376-32377 -RRB- denotes )
T19587 32378-32382 VBD denotes were
T19588 32383-32391 VBN denotes cultured
T19589 32392-32394 IN denotes as
T19590 32395-32401 IN denotes before
T19591 32402-32403 -LRB- denotes (
T19592 32403-32409 NNP denotes Hosken
T19593 32410-32412 FW denotes et
T19594 32413-32416 FW denotes al.
T19595 32416-32417 , denotes ,
T19596 32418-32422 CD denotes 1995
T19597 32422-32423 -RRB- denotes )
T19598 32423-32424 , denotes ,
T19599 32425-32427 IN denotes in
T19600 32428-32429 DT denotes a
T19601 32430-32435 JJ denotes total
T19602 32436-32442 NN denotes volume
T19603 32443-32445 IN denotes of
T19604 32446-32447 CD denotes 1
T19605 32448-32450 NN denotes ml
T19606 32451-32456 NNP denotes cRPMI
T19607 32457-32463 NN denotes medium
T19608 32464-32466 IN denotes in
T19609 32467-32468 DT denotes a
T19610 32469-32476 JJ denotes 48-well
T19611 32477-32482 NN denotes plate
T19612 32482-32483 , denotes ,
T19613 32484-32488 IN denotes with
T19614 32489-32496 JJ denotes splenic
T19615 32497-32500 NNS denotes DCs
T19616 32501-32502 -LRB- denotes (
T19617 32502-32503 CD denotes 2
T19618 32504-32505 CD denotes ×
T19619 32506-32509 CD denotes 104
T19620 32510-32518 NN denotes cells/ml
T19621 32518-32519 -RRB- denotes )
T19622 32519-32520 , denotes ,
T19623 32521-32524 CC denotes and
T19624 32525-32532 VBG denotes varying
T19625 32533-32540 NNS denotes amounts
T19626 32541-32543 IN denotes of
T19627 32544-32547 NNP denotes OVA
T19628 32548-32551 CC denotes and
T19629 32552-32554 IN denotes of
T19630 32555-32560 NN denotes IL-12
T19631 32560-32561 . denotes .
T19632 32562-32577 JJ denotes APC-independent
T19633 32578-32593 NN denotes differentiation
T19634 32594-32596 IN denotes of
T19635 32597-32602 JJ denotes naive
T19636 32603-32606 NNP denotes CD4
T19637 32606-32607 CD denotes +
T19638 32608-32609 NNP denotes T
T19639 32610-32615 NNS denotes cells
T19640 32616-32620 IN denotes into
T19641 32621-32624 JJ denotes Th1
T19642 32625-32628 CC denotes and
T19643 32629-32632 JJ denotes Th2
T19644 32633-32638 NNS denotes cells
T19645 32639-32643 VBN denotes used
T19646 32644-32655 NN denotes stimulation
T19647 32656-32660 IN denotes with
T19648 32661-32669 JJ denotes anti-CD3
T19649 32670-32673 CC denotes and
T19650 32674-32683 JJ denotes anti-CD28
T19651 32684-32687 CC denotes and
T19652 32688-32699 JJ denotes appropriate
T19653 32700-32708 NN denotes cytokine
T19654 32709-32719 NNS denotes conditions
T19655 32719-32720 , denotes ,
T19656 32721-32724 CC denotes and
T19657 32725-32732 NN denotes control
T19658 32733-32736 NNP denotes Th1
T19659 32737-32740 CC denotes and
T19660 32741-32744 NNP denotes Th2
T19661 32745-32750 NNS denotes cells
T19662 32751-32755 VBD denotes were
T19663 32756-32764 VBN denotes cultured
T19664 32765-32767 IN denotes as
T19665 32768-32777 VBN denotes described
T19666 32778-32784 IN denotes before
T19667 32785-32786 -LRB- denotes (
T19668 32786-32792 NNP denotes Hosken
T19669 32793-32795 FW denotes et
T19670 32796-32799 FW denotes al.
T19671 32799-32800 , denotes ,
T19672 32801-32805 CD denotes 1995
T19673 32805-32806 : denotes ;
T19674 32807-32816 NNP denotes Shoemaker
T19675 32817-32819 FW denotes et
T19676 32820-32823 FW denotes al.
T19677 32823-32824 , denotes ,
T19678 32825-32829 CD denotes 2006
T19679 32829-32830 -RRB- denotes )
T19680 32830-32831 . denotes .
T19681 32832-32839 NNP denotes Culture
T19682 32840-32850 NNS denotes conditions
T19683 32851-32854 IN denotes for
T19684 32855-32859 NNP denotes Th17
T19685 32860-32865 NNS denotes cells
T19686 32866-32870 VBD denotes were
T19687 32871-32873 IN denotes as
T19688 32874-32883 VBN denotes described
T19689 32884-32890 IN denotes before
T19690 32891-32892 -LRB- denotes (
T19691 32892-32900 NNP denotes Veldhoen
T19692 32901-32903 FW denotes et
T19693 32904-32907 FW denotes al.
T19694 32907-32908 , denotes ,
T19695 32909-32913 CD denotes 2006
T19696 32913-32914 -RRB- denotes )
T19697 32914-32915 . denotes .
T19698 32916-32927 RB denotes Importantly
T19699 32927-32928 , denotes ,
T19700 32929-32932 NNP denotes Th1
T19701 32933-32936 CC denotes and
T19702 32937-32940 NNP denotes Th2
T19703 32941-32946 NNS denotes cells
T19704 32947-32952 MD denotes could
T19705 32953-32955 VB denotes be
T19706 32956-32970 VBN denotes differentiated
T19707 32971-32973 IN denotes in
T19708 32974-32979 NNP denotes cRPMI
T19709 32980-32982 CC denotes or
T19710 32983-32987 NNP denotes IMDM
T19711 32988-32989 -LRB- denotes (
T19712 32989-32995 NNP denotes Hosken
T19713 32996-32998 FW denotes et
T19714 32999-33002 FW denotes al.
T19715 33002-33003 , denotes ,
T19716 33004-33008 CD denotes 1995
T19717 33008-33009 : denotes ;
T19718 33010-33019 NNP denotes Shoemaker
T19719 33020-33022 FW denotes et
T19720 33023-33026 FW denotes al.
T19721 33026-33027 , denotes ,
T19722 33028-33032 CD denotes 2006
T19723 33032-33033 : denotes ;
T19724 33034-33042 NNP denotes Veldhoen
T19725 33043-33045 FW denotes et
T19726 33046-33049 FW denotes al.
T19727 33049-33050 , denotes ,
T19728 33051-33055 CD denotes 2006
T19729 33055-33056 -RRB- denotes )
T19730 33056-33057 , denotes ,
T19731 33058-33061 CC denotes but
T19732 33062-33066 NNP denotes Th17
T19733 33067-33072 NNS denotes cells
T19734 33073-33077 VBD denotes were
T19735 33078-33082 RB denotes only
T19736 33083-33097 JJ denotes differentiated
T19737 33098-33107 RB denotes optimally
T19738 33108-33110 IN denotes in
T19739 33111-33115 NNP denotes IMDM
T19740 33116-33117 -LRB- denotes (
T19741 33117-33125 NNP denotes Veldhoen
T19742 33126-33128 FW denotes et
T19743 33129-33132 FW denotes al.
T19744 33132-33133 , denotes ,
T19745 33134-33138 CD denotes 2009
T19746 33138-33139 -RRB- denotes )
T19747 33139-33140 . denotes .
T19748 33141-33145 WRB denotes When
T19749 33146-33155 VBN denotes indicated
T19750 33155-33156 , denotes ,
T19751 33157-33162 NNP denotes U0126
T19752 33163-33165 CC denotes or
T19753 33166-33174 NNP denotes PD184352
T19754 33175-33176 -LRB- denotes (
T19755 33176-33179 NNP denotes MEK
T19756 33180-33190 NNS denotes inhibitors
T19757 33190-33191 -RRB- denotes )
T19758 33191-33192 , denotes ,
T19759 33193-33201 NNP denotes SB203580
T19760 33202-33203 -LRB- denotes (
T19761 33203-33206 CD denotes p38
T19762 33207-33216 NN denotes inhibitor
T19763 33216-33217 -RRB- denotes )
T19764 33217-33218 , denotes ,
T19765 33219-33226 NNP denotes CT99021
T19766 33227-33228 -LRB- denotes (
T19767 33228-33233 NNP denotes GSK3β
T19768 33234-33243 NN denotes inhibitor
T19769 33243-33244 -RRB- denotes )
T19770 33244-33245 , denotes ,
T19771 33246-33248 CC denotes or
T19772 33249-33250 DT denotes a
T19773 33251-33258 JJ denotes similar
T19774 33259-33265 NN denotes amount
T19775 33266-33268 IN denotes of
T19776 33269-33273 NNP denotes DMSO
T19777 33274-33278 VBD denotes were
T19778 33279-33286 JJ denotes present
T19779 33287-33289 IN denotes in
T19780 33290-33293 DT denotes the
T19781 33294-33301 NN denotes culture
T19782 33301-33302 . denotes .
T19783 33303-33307 JJR denotes More
T19784 33308-33315 NNS denotes details
T19785 33316-33318 IN denotes of
T19786 33319-33327 JJ denotes specific
T19787 33328-33335 NN denotes culture
T19788 33336-33346 NNS denotes conditions
T19789 33347-33350 VBP denotes are
T19790 33351-33359 VBN denotes provided
T19791 33360-33362 IN denotes in
T19792 33363-33370 NNS denotes Figures
T19793 33371-33373 NNP denotes S6
T19794 33374-33377 CC denotes and
T19795 33378-33380 NNP denotes S7
T19796 33380-33381 . denotes .
T20063 33383-33391 NNP denotes Cytokine
T20064 33392-33401 NNP denotes Detection
T20065 33402-33404 IN denotes by
T20066 33405-33408 NNP denotes ICS
T20067 33409-33412 CC denotes and
T20068 33413-33418 NNP denotes ELISA
T20069 33419-33421 IN denotes At
T20070 33422-33425 NN denotes day
T20071 33426-33427 CD denotes 5
T20072 33428-33430 CC denotes or
T20073 33431-33432 CD denotes 7
T20074 33432-33433 , denotes ,
T20075 33434-33439 NNS denotes cells
T20076 33440-33444 VBD denotes were
T20077 33445-33457 VBN denotes restimulated
T20078 33458-33462 IN denotes with
T20079 33463-33474 JJ denotes immobilized
T20080 33475-33483 JJ denotes anti-CD3
T20081 33484-33485 -LRB- denotes (
T20082 33485-33486 CD denotes 2
T20083 33487-33489 NN denotes μg
T20084 33489-33490 NN denotes /
T20085 33490-33492 NN denotes ml
T20086 33492-33493 -RRB- denotes )
T20087 33494-33497 CC denotes and
T20088 33498-33507 JJ denotes anti-CD28
T20089 33508-33509 -LRB- denotes (
T20090 33509-33510 CD denotes 2
T20091 33511-33513 NN denotes μg
T20092 33513-33514 NN denotes /
T20093 33514-33516 NN denotes ml
T20094 33516-33517 -RRB- denotes )
T20095 33518-33519 -LRB- denotes (
T20096 33519-33520 CD denotes 4
T20097 33521-33523 NN denotes hr
T20098 33524-33528 IN denotes with
T20099 33529-33539 NNP denotes BrefeldinA
T20100 33540-33541 NNP denotes [
T20101 33541-33543 CD denotes 10
T20102 33544-33546 NN denotes μg
T20103 33546-33547 NN denotes /
T20104 33547-33549 NN denotes ml
T20105 33549-33550 NNP denotes ]
T20106 33551-33553 IN denotes in
T20107 33554-33557 DT denotes the
T20108 33558-33562 JJ denotes last
T20109 33563-33564 CD denotes 2
T20110 33565-33567 NN denotes hr
T20111 33567-33568 -RRB- denotes )
T20112 33569-33571 CC denotes or
T20113 33572-33576 IN denotes with
T20114 33577-33581 NNP denotes PdBU
T20115 33582-33585 CC denotes and
T20116 33586-33595 NNP denotes Ionomycin
T20117 33596-33597 -LRB- denotes (
T20118 33597-33598 CD denotes 5
T20119 33599-33601 NN denotes hr
T20120 33602-33606 IN denotes with
T20121 33607-33617 NNP denotes BrefeldinA
T20122 33618-33619 NNP denotes [
T20123 33619-33620 CD denotes 1
T20124 33621-33623 NN denotes μg
T20125 33623-33624 NN denotes /
T20126 33624-33626 NN denotes ml
T20127 33626-33627 NNP denotes ]
T20128 33627-33628 -RRB- denotes )
T20129 33628-33629 . denotes .
T20130 33630-33635 IN denotes After
T20131 33636-33639 NNP denotes ICS
T20132 33640-33644 NNP denotes FACS
T20133 33644-33645 , denotes ,
T20134 33646-33650 NNS denotes data
T20135 33651-33655 VBD denotes were
T20136 33656-33665 VBN denotes collected
T20137 33666-33668 IN denotes on
T20138 33669-33670 DT denotes a
T20139 33671-33682 NNP denotes FACSCalibur
T20140 33683-33684 -LRB- denotes (
T20141 33684-33690 NNP denotes Becton
T20142 33691-33700 NNP denotes Dickinson
T20143 33700-33701 -RRB- denotes )
T20144 33702-33705 CC denotes and
T20145 33706-33714 VBD denotes analyzed
T20146 33715-33719 IN denotes with
T20147 33720-33726 NNP denotes FlowJo
T20148 33727-33728 -LRB- denotes (
T20149 33728-33732 NNP denotes Tree
T20150 33733-33737 NNP denotes Star
T20151 33737-33738 -RRB- denotes )
T20152 33738-33739 . denotes .
T20153 33740-33743 IN denotes For
T20154 33744-33749 NNP denotes ELISA
T20155 33749-33750 , denotes ,
T20156 33751-33756 NNS denotes cells
T20157 33757-33761 VBD denotes were
T20158 33762-33771 RB denotes similarly
T20159 33772-33784 VBN denotes restimulated
T20160 33785-33788 IN denotes for
T20161 33789-33791 CD denotes 48
T20162 33792-33794 NN denotes hr
T20163 33795-33798 CC denotes and
T20164 33799-33810 NN denotes supernatant
T20165 33811-33814 VBD denotes was
T20166 33815-33824 VBN denotes collected
T20167 33825-33828 CC denotes and
T20168 33829-33837 VBN denotes analyzed
T20169 33838-33841 IN denotes for
T20170 33842-33846 NN denotes IL-4
T20171 33846-33847 , denotes ,
T20172 33848-33853 NNP denotes IL-10
T20173 33853-33854 , denotes ,
T20174 33855-33858 CC denotes and
T20175 33859-33864 NNP denotes IFN-γ
T20176 33865-33867 IN denotes as
T20177 33868-33877 VBN denotes described
T20178 33878-33884 IN denotes before
T20179 33885-33886 -LRB- denotes (
T20180 33886-33895 NN denotes Shoemaker
T20181 33896-33898 FW denotes et
T20182 33899-33902 FW denotes al.
T20183 33902-33903 , denotes ,
T20184 33904-33908 CD denotes 2006
T20185 33908-33909 -RRB- denotes )
T20186 33909-33910 . denotes .
T20407 33912-33914 IN denotes In
T20408 33915-33919 NNP denotes Vivo
T20409 33920-33927 NNP denotes Studies
T20410 33928-33934 NNP denotes BALB/c
T20411 33935-33939 NNS denotes mice
T20412 33940-33944 VBD denotes were
T20413 33945-33953 VBN denotes injected
T20414 33954-33967 RB denotes intravenously
T20415 33968-33969 -LRB- denotes (
T20416 33969-33973 FW denotes i.v.
T20417 33973-33974 -RRB- denotes )
T20418 33975-33979 IN denotes with
T20419 33980-33981 DT denotes a
T20420 33982-33985 JJ denotes red
T20421 33986-33991 NN denotes blood
T20422 33992-34005 JJ denotes cell-depleted
T20423 34006-34017 JJ denotes single-cell
T20424 34018-34024 JJ denotes spleen
T20425 34025-34035 NN denotes suspension
T20426 34036-34037 -LRB- denotes (
T20427 34037-34040 CD denotes 2.5
T20428 34041-34042 CD denotes ×
T20429 34043-34046 CD denotes 107
T20430 34047-34052 NNS denotes cells
T20431 34052-34053 -RRB- denotes )
T20432 34054-34055 -LRB- denotes (
T20433 34055-34061 NNP denotes Castro
T20434 34062-34064 FW denotes et
T20435 34065-34068 FW denotes al.
T20436 34068-34069 , denotes ,
T20437 34070-34074 CD denotes 2000
T20438 34074-34075 -RRB- denotes )
T20439 34076-34080 IN denotes from
T20440 34081-34085 CD denotes DO11
T20441 34085-34088 CD denotes .10
T20442 34089-34091 NNP denotes WT
T20443 34092-34094 CC denotes or
T20444 34095-34109 JJ denotes STAT-deficient
T20445 34110-34114 NNS denotes mice
T20446 34114-34115 . denotes .
T20447 34116-34121 IN denotes After
T20448 34122-34124 CD denotes 48
T20449 34125-34127 NN denotes hr
T20450 34127-34128 , denotes ,
T20451 34129-34133 PRP denotes they
T20452 34134-34138 VBD denotes were
T20453 34139-34147 VBN denotes injected
T20454 34148-34162 RB denotes subcutaneously
T20455 34163-34167 IN denotes with
T20456 34168-34171 NNP denotes PBS
T20457 34172-34174 CC denotes or
T20458 34175-34179 IN denotes with
T20459 34180-34183 NNP denotes OVA
T20460 34184-34191 NN denotes protein
T20461 34192-34193 -LRB- denotes (
T20462 34193-34194 CD denotes 5
T20463 34195-34197 NN denotes mg
T20464 34197-34198 -RRB- denotes )
T20465 34199-34203 CC denotes plus
T20466 34204-34207 NNP denotes LPS
T20467 34208-34209 -LRB- denotes (
T20468 34209-34210 CD denotes 5
T20469 34211-34213 NN denotes μg
T20470 34213-34214 -RRB- denotes )
T20471 34214-34215 . denotes .
T20472 34216-34219 DT denotes The
T20473 34220-34228 JJ denotes inguinal
T20474 34229-34234 NN denotes lymph
T20475 34235-34240 NNS denotes nodes
T20476 34241-34245 VBD denotes were
T20477 34246-34253 VBN denotes removed
T20478 34254-34256 CD denotes 48
T20479 34257-34259 NN denotes hr
T20480 34260-34265 RB denotes later
T20481 34265-34266 . denotes .
T20482 34267-34268 DT denotes A
T20483 34269-34280 JJ denotes single-cell
T20484 34281-34291 NN denotes suspension
T20485 34292-34293 -LRB- denotes (
T20486 34293-34294 CD denotes 1
T20487 34295-34296 CD denotes ×
T20488 34297-34300 CD denotes 106
T20489 34301-34306 NNS denotes cells
T20490 34306-34307 -RRB- denotes )
T20491 34308-34311 VBD denotes was
T20492 34312-34324 VBN denotes restimulated
T20493 34325-34328 IN denotes for
T20494 34329-34331 CD denotes 24
T20495 34332-34334 CC denotes or
T20496 34335-34337 CD denotes 48
T20497 34338-34340 NN denotes hr
T20498 34341-34345 IN denotes with
T20499 34346-34347 CD denotes 1
T20500 34348-34350 NN denotes μM
T20501 34351-34353 CC denotes or
T20502 34354-34355 CD denotes 3
T20503 34356-34358 NN denotes μM
T20504 34359-34361 IN denotes of
T20505 34362-34365 NNP denotes OVA
T20506 34366-34369 CC denotes and
T20507 34370-34374 IN denotes with
T20508 34375-34385 NNP denotes BrefeldinA
T20509 34386-34389 IN denotes for
T20510 34390-34393 DT denotes the
T20511 34394-34398 JJ denotes last
T20512 34399-34400 CD denotes 6
T20513 34401-34403 NN denotes hr
T20514 34403-34404 . denotes .
T20515 34405-34409 NN denotes Half
T20516 34410-34412 IN denotes of
T20517 34413-34416 DT denotes the
T20518 34417-34428 NN denotes supernatant
T20519 34429-34432 VBD denotes was
T20520 34433-34440 VBN denotes removed
T20521 34441-34447 IN denotes before
T20522 34448-34451 DT denotes the
T20523 34452-34460 NN denotes addition
T20524 34461-34463 IN denotes of
T20525 34464-34474 NNP denotes BrefeldinA
T20526 34475-34478 IN denotes for
T20527 34479-34482 NN denotes use
T20528 34483-34485 IN denotes in
T20529 34486-34488 DT denotes an
T20530 34489-34494 NNP denotes ELISA
T20531 34495-34500 NN denotes assay
T20532 34500-34501 . denotes .
T20533 34502-34505 DT denotes The
T20534 34506-34511 NNS denotes cells
T20535 34512-34516 VBD denotes were
T20536 34517-34522 VBN denotes fixed
T20537 34523-34526 CC denotes and
T20538 34527-34534 VBN denotes stained
T20539 34535-34537 IN denotes as
T20540 34538-34544 RB denotes before
T20541 34544-34545 . denotes .
T20542 34546-34551 DT denotes Those
T20543 34552-34560 JJ denotes positive
T20544 34561-34564 IN denotes for
T20545 34565-34575 NN denotes KJ1-26-Bio
T20546 34576-34579 CC denotes and
T20547 34580-34583 IN denotes for
T20548 34584-34593 JJ denotes CD4-PerCP
T20549 34594-34598 VBD denotes were
T20550 34599-34604 VBN denotes gated
T20551 34604-34605 , denotes ,
T20552 34606-34609 CC denotes and
T20553 34610-34615 NNP denotes IFN-γ
T20554 34616-34619 CC denotes and
T20555 34620-34625 NNP denotes IL-10
T20556 34626-34634 VBG denotes staining
T20557 34635-34638 VBD denotes was
T20558 34639-34647 VBN denotes examined
T20559 34648-34651 IN denotes for
T20560 34652-34656 DT denotes this
T20561 34657-34667 NN denotes population
T20562 34668-34671 CC denotes and
T20563 34672-34680 VBD denotes analyzed
T20564 34681-34683 IN denotes as
T20565 34684-34690 RB denotes before
T20566 34690-34691 . denotes .
T20730 34693-34702 JJ denotes Real-Time
T20731 34703-34715 JJ denotes Quantitative
T20732 34716-34722 NNP denotes RT-PCR
T20733 34723-34728 NNPS denotes Cells
T20734 34729-34733 VBD denotes were
T20735 34734-34743 VBN denotes harvested
T20736 34744-34747 CC denotes and
T20737 34748-34760 VBN denotes restimulated
T20738 34761-34763 IN denotes in
T20739 34764-34767 DT denotes the
T20740 34768-34776 NN denotes presence
T20741 34777-34779 IN denotes of
T20742 34780-34791 VBN denotes immobilized
T20743 34792-34800 JJ denotes anti-CD3
T20744 34801-34802 -LRB- denotes (
T20745 34802-34803 CD denotes 2
T20746 34804-34806 NN denotes μg
T20747 34806-34807 NN denotes /
T20748 34807-34809 NN denotes ml
T20749 34809-34810 -RRB- denotes )
T20750 34811-34815 CC denotes plus
T20751 34816-34825 JJ denotes anti-CD28
T20752 34826-34827 -LRB- denotes (
T20753 34827-34828 CD denotes 2
T20754 34829-34831 NN denotes μg
T20755 34831-34832 NN denotes /
T20756 34832-34834 NN denotes ml
T20757 34834-34835 -RRB- denotes )
T20758 34836-34839 IN denotes for
T20759 34840-34841 CD denotes 3
T20760 34842-34844 NN denotes hr
T20761 34845-34847 CC denotes or
T20762 34848-34859 RB denotes immediately
T20763 34860-34865 VBD denotes lysed
T20764 34865-34866 . denotes .
T20765 34867-34870 NNP denotes RNA
T20766 34871-34874 VBD denotes was
T20767 34875-34884 VBN denotes extracted
T20768 34885-34888 CC denotes and
T20769 34889-34908 JJ denotes reverse-transcribed
T20770 34909-34912 CC denotes and
T20771 34913-34917 NNP denotes cDNA
T20772 34918-34921 VBD denotes was
T20773 34922-34930 VBN denotes analyzed
T20774 34931-34934 IN denotes for
T20775 34935-34938 DT denotes the
T20776 34939-34949 NN denotes expression
T20777 34950-34952 IN denotes of
T20778 34953-34962 NNS denotes cytokines
T20779 34963-34966 CC denotes and
T20780 34967-34980 NN denotes transcription
T20781 34981-34988 NNS denotes factors
T20782 34989-34991 IN denotes by
T20783 34992-35001 JJ denotes real-time
T20784 35002-35005 NNP denotes PCR
T20785 35006-35011 NN denotes assay
T20786 35012-35014 IN denotes as
T20787 35015-35021 IN denotes before
T20788 35022-35023 -LRB- denotes (
T20789 35023-35032 NN denotes Shoemaker
T20790 35033-35035 FW denotes et
T20791 35036-35039 FW denotes al.
T20792 35039-35040 , denotes ,
T20793 35041-35045 CD denotes 2006
T20794 35045-35046 -RRB- denotes )
T20795 35046-35047 . denotes .
T20796 35048-35054 NN denotes Target
T20797 35055-35059 NN denotes gene
T20798 35060-35064 NNP denotes mRNA
T20799 35065-35075 NN denotes expression
T20800 35076-35079 VBD denotes was
T20801 35080-35090 VBN denotes quantified
T20802 35091-35097 RB denotes either
T20803 35098-35102 IN denotes with
T20804 35103-35107 NNP denotes SYBR
T20805 35108-35113 NNP denotes Green
T20806 35114-35115 -LRB- denotes (
T20807 35115-35122 NNP denotes Applied
T20808 35123-35133 NNPS denotes Biosystems
T20809 35133-35134 -RRB- denotes )
T20810 35135-35137 CC denotes or
T20811 35138-35142 IN denotes with
T20812 35143-35149 NNP denotes Master
T20813 35150-35153 NNP denotes Mix
T20814 35154-35155 -LRB- denotes (
T20815 35155-35162 NNP denotes Applied
T20816 35163-35173 NNPS denotes Biosystems
T20817 35173-35174 -RRB- denotes )
T20818 35175-35178 CC denotes and
T20819 35179-35189 VBN denotes normalized
T20820 35190-35192 TO denotes to
T20821 35193-35202 VB denotes ubiquitin
T20822 35203-35205 CC denotes or
T20823 35206-35210 NNP denotes HPRT
T20824 35211-35215 NNP denotes mRNA
T20825 35216-35222 NNS denotes levels
T20826 35222-35223 , denotes ,
T20827 35224-35236 RB denotes respectively
T20828 35236-35237 . denotes .
T20925 35239-35253 NNP denotes Immunoblotting
T20926 35254-35268 NNP denotes Differentiated
T20927 35269-35272 NNP denotes CD4
T20928 35272-35273 VBD denotes +
T20929 35274-35275 NNP denotes T
T20930 35276-35281 NNS denotes cells
T20931 35282-35286 VBD denotes were
T20932 35287-35293 VBN denotes rested
T20933 35294-35297 IN denotes for
T20934 35298-35299 CD denotes 5
T20935 35300-35302 NN denotes hr
T20936 35303-35305 IN denotes in
T20937 35306-35307 CD denotes 1
T20938 35307-35308 NN denotes %
T20939 35309-35323 JJ denotes FCS-containing
T20940 35324-35330 NN denotes medium
T20941 35331-35334 CC denotes and
T20942 35335-35347 VBD denotes restimulated
T20943 35348-35350 IN denotes as
T20944 35351-35360 VBN denotes described
T20945 35361-35364 IN denotes for
T20976 35545-35551 NNP denotes Beinke
T20977 35552-35554 FW denotes et
T20978 35555-35558 FW denotes al.
T20979 35558-35559 , denotes ,
T20980 35560-35564 CD denotes 2004
T20981 35564-35565 -RRB- denotes )
T20982 35565-35566 . denotes .
T20946 35365-35373 JJ denotes specific
T20947 35374-35385 NNS denotes experiments
T20948 35385-35386 . denotes .
T20949 35387-35391 NN denotes Cell
T20950 35392-35399 NNS denotes lysates
T20951 35400-35404 VBD denotes were
T20952 35405-35413 VBN denotes prepared
T20953 35413-35414 , denotes ,
T20954 35415-35420 JJ denotes equal
T20955 35421-35428 NNS denotes amounts
T20956 35429-35431 IN denotes of
T20957 35432-35439 NN denotes protein
T20958 35440-35444 VBD denotes were
T20959 35445-35454 VBN denotes separated
T20960 35455-35457 IN denotes by
T20961 35458-35466 NNP denotes SDS-PAGE
T20962 35466-35467 , denotes ,
T20963 35468-35471 CC denotes and
T20964 35472-35486 VBD denotes phosphorylated
T20965 35487-35489 CC denotes or
T20966 35490-35495 JJ denotes total
T20967 35496-35499 NNP denotes ERK
T20968 35500-35503 CC denotes and
T20969 35504-35509 NN denotes actin
T20970 35510-35514 VBD denotes were
T20971 35515-35523 VBN denotes detected
T20972 35524-35526 IN denotes as
T20973 35527-35536 VBN denotes described
T20974 35537-35543 IN denotes before
T20975 35544-35545 -LRB- denotes (
R249 T365 T366 compound Interleukin-10,Production
R250 T366 T370 nsubj Production,Requires
R251 T367 T366 prep by,Production
R252 T368 T369 compound Th1,Cells
R253 T369 T367 pobj Cells,by
R254 T370 T370 ROOT Requires,Requires
R255 T371 T372 compound Interleukin-12-Induced,STAT4
R256 T372 T374 compound STAT4,Factor
R257 T373 T374 compound Transcription,Factor
R258 T374 T370 dobj Factor,Requires
R259 T375 T374 cc and,Factor
R260 T376 T379 compound ERK,Activation
R261 T377 T379 compound MAP,Activation
R262 T378 T379 compound Kinase,Activation
R263 T379 T374 conj Activation,Factor
R264 T380 T374 prep by,Factor
R265 T381 T382 compound High,Antigen
R266 T382 T383 compound Antigen,Dose
R267 T383 T385 compound Dose,CD4
R268 T384 T385 compound Summary,CD4
R269 T385 T380 pobj CD4,by
R270 T386 T388 amod +,cells
R271 T387 T388 compound T,cells
R272 T388 T370 dobj cells,Requires
R273 T389 T388 acl producing,cells
R274 T390 T389 dobj interleukin-10,producing
R275 T391 T392 punct (,IL-10
R276 T392 T390 appos IL-10,interleukin-10
R277 T393 T392 punct ),IL-10
R278 T394 T390 cc and,interleukin-10
R279 T395 T390 conj interferon-γ,interleukin-10
R280 T396 T395 punct (,interferon-γ
R281 T397 T395 appos IFN-γ,interferon-γ
R282 T398 T395 punct ),interferon-γ
R283 T399 T400 auxpass are,reported
R284 T400 T370 conj reported,Requires
R285 T401 T400 prep in,reported
R286 T402 T403 amod chronic,infections
R287 T403 T401 pobj infections,in
R288 T404 T370 punct .,Requires
R289 T405 T422 advmod However,are
R290 T406 T422 punct ",",are
R291 T407 T408 det the,signals
R292 T408 T422 nsubj signals,are
R293 T409 T410 nsubj that,direct
R294 T410 T408 relcl direct,signals
R295 T411 T412 det the,development
R296 T412 T410 dobj development,direct
R297 T413 T412 prep of,development
R298 T414 T416 amod IL-10-producing,helper
R299 T415 T416 compound T,helper
R300 T416 T413 pobj helper,of
R301 T417 T416 nummod 1,helper
R302 T418 T416 punct (,helper
R303 T419 T416 appos Th1,helper
R304 T420 T416 punct ),helper
R305 T421 T413 pobj cells,of
R306 T422 T422 ROOT are,are
R307 T423 T422 acomp undefined,are
R308 T424 T422 punct .,are
R309 T425 T426 nsubj We,showed
R310 T426 T426 ROOT showed,showed
R311 T427 T433 mark that,required
R312 T428 T433 nsubj development,required
R313 T429 T428 prep of,development
R314 T430 T432 amod IL-10-producing,cells
R315 T431 T432 amod Th1,cells
R316 T432 T429 pobj cells,of
R317 T433 T426 ccomp required,showed
R318 T434 T437 amod high,receptor
R319 T435 T437 compound T,receptor
R320 T436 T437 compound cell,receptor
R321 T437 T433 dobj receptor,required
R322 T438 T437 punct (,receptor
R323 T439 T437 appos TCR,receptor
R324 T440 T437 punct ),receptor
R325 T441 T437 appos ligation,receptor
R326 T442 T437 punct ",",receptor
R327 T443 T433 conj sustained,required
R328 T444 T443 dobj ERK1,sustained
R329 T445 T444 cc and,ERK1
R330 T446 T449 nummod ERK2,phosphorylation
R331 T447 T449 nmod MAP,phosphorylation
R332 T448 T449 compound kinases,phosphorylation
R333 T449 T456 nmod phosphorylation,activation
R334 T450 T449 punct ",",phosphorylation
R335 T451 T449 cc and,phosphorylation
R336 T452 T449 conj IL-12-induced,phosphorylation
R337 T453 T456 nummod STAT4,activation
R338 T454 T455 compound transcription,factor
R339 T455 T456 compound factor,activation
R340 T456 T444 conj activation,ERK1
R341 T457 T426 punct .,showed
R342 T458 T459 compound Repeated,TCR
R343 T459 T461 nsubj TCR,led
R344 T460 T459 acl triggering,TCR
R345 T461 T461 ROOT led,led
R346 T462 T461 prep to,led
R347 T463 T465 amod enhanced,production
R348 T464 T465 compound IL-10,production
R349 T465 T462 pobj production,to
R350 T466 T465 prep by,production
R351 T467 T468 amod Th1,cells
R352 T468 T466 pobj cells,by
R353 T469 T461 punct ",",led
R354 T470 T461 cc and,led
R355 T471 T461 conj continued,led
R356 T472 T473 amod IL-12,action
R357 T473 T471 dobj action,continued
R358 T474 T473 cc and,action
R359 T475 T477 amod high-dose,signaling
R360 T476 T477 compound TCR,signaling
R361 T477 T479 nsubjpass signaling,required
R362 T478 T479 auxpass were,required
R363 T479 T461 conj required,led
R364 T480 T479 prep for,required
R365 T481 T482 det the,development
R366 T482 T480 pobj development,for
R367 T483 T482 cc and,development
R368 T484 T482 conj maintenance,development
R369 T485 T484 prep of,maintenance
R370 T486 T488 amod IL-10-producing,cells
R371 T487 T488 amod Th1,cells
R372 T488 T485 pobj cells,of
R373 T489 T479 punct .,required
R374 T490 T498 mark Although,require
R375 T491 T497 nmod Th1,cells
R376 T492 T491 punct ",",Th1
R377 T493 T491 conj Th2,Th1
R378 T494 T493 punct ",",Th2
R379 T495 T493 cc and,Th2
R380 T496 T493 conj Th17,Th2
R381 T497 T498 nsubj cells,require
R382 T498 T513 advcl require,was
R383 T499 T500 det the,activation
R384 T500 T498 dobj activation,require
R385 T501 T500 prep of,activation
R386 T502 T503 amod distinct,STATs
R387 T503 T501 pobj STATs,of
R388 T504 T500 prep for,activation
R389 T505 T506 poss their,differentiation
R390 T506 T504 pobj differentiation,for
R391 T507 T506 punct ",",differentiation
R392 T508 T500 conj activation,activation
R393 T509 T500 prep of,activation
R394 T510 T509 pobj ERK1,of
R395 T511 T510 cc and,ERK1
R396 T512 T510 conj ERK2,ERK1
R397 T513 T513 ROOT was,was
R398 T514 T516 det a,requirement
R399 T515 T516 amod common,requirement
R400 T516 T513 attr requirement,was
R401 T517 T516 prep for,requirement
R402 T518 T517 pobj production,for
R403 T519 T518 prep of,production
R404 T520 T519 pobj IL-10,of
R405 T521 T516 prep by,requirement
R406 T522 T525 det all,subsets
R407 T523 T525 compound Th,subsets
R408 T524 T525 compound cell,subsets
R409 T525 T521 pobj subsets,by
R410 T526 T513 punct .,was
R411 T527 T528 compound IL-10,expression
R412 T528 T528 ROOT expression,expression
R413 T529 T530 advmod also,correlated
R414 T530 T528 acl correlated,expression
R415 T531 T530 prep with,correlated
R416 T532 T533 amod c-maf,expression
R417 T533 T531 pobj expression,with
R418 T534 T528 punct .,expression
R419 T535 T547 prep Despite,share
R420 T536 T535 pcomp having,Despite
R421 T537 T538 amod distinct,functions
R422 T538 T536 dobj functions,having
R423 T539 T536 prep in,having
R424 T540 T539 pobj protection,in
R425 T541 T540 prep against,protection
R426 T542 T541 pobj pathogens,against
R427 T543 T547 punct ",",share
R428 T544 T546 det all,cells
R429 T545 T546 compound Th,cells
R430 T546 T547 nsubj cells,share
R431 T547 T547 ROOT share,share
R432 T548 T550 det the,task
R433 T549 T550 amod important,task
R434 T550 T547 dobj task,share
R435 T551 T550 prep of,task
R436 T552 T551 pcomp controlling,of
R437 T553 T555 amod overexuberant,responses
R438 T554 T555 amod immune,responses
R439 T555 T552 dobj responses,controlling
R440 T556 T552 prep by,controlling
R441 T557 T556 pobj means,by
R442 T558 T557 prep of,means
R443 T559 T560 compound IL-10,production
R444 T560 T558 pobj production,of
R445 T561 T547 punct .,share
R812 T1192 T1196 nsubj Interleukin-10,is
R813 T1193 T1194 punct (,IL-10
R814 T1194 T1192 appos IL-10,Interleukin-10
R815 T1195 T1192 punct ),Interleukin-10
R816 T1196 T1196 ROOT is,is
R817 T1197 T1198 det a,cytokine
R818 T1198 T1196 attr cytokine,is
R819 T1199 T1198 prep with,cytokine
R820 T1200 T1202 amod broad,properties
R821 T1201 T1202 amod anti-inflammatory,properties
R822 T1202 T1199 pobj properties,with
R823 T1203 T1204 nsubj that,inhibits
R824 T1204 T1202 relcl inhibits,properties
R825 T1205 T1212 nmod macrophage,function
R826 T1206 T1205 cc and,macrophage
R827 T1207 T1208 amod dendritic,cell
R828 T1208 T1205 conj cell,macrophage
R829 T1209 T1210 punct (,DC
R830 T1210 T1208 appos DC,cell
R831 T1211 T1208 punct ),cell
R832 T1212 T1204 dobj function,inhibits
R833 T1213 T1216 punct (,al.
R834 T1214 T1216 compound Moore,al.
R835 T1215 T1216 nmod et,al.
R836 T1216 T1202 appos al.,properties
R837 T1217 T1216 punct ",",al.
R838 T1218 T1216 npadvmod 2001,al.
R839 T1219 T1198 punct ),cytokine
R840 T1220 T1196 punct .,is
R841 T1221 T1222 amod IL-10,limits
R842 T1222 T1257 nsubj limits,result
R843 T1223 T1227 det the,responses
R844 T1224 T1227 amod immune,responses
R845 T1225 T1224 cc and,immune
R846 T1226 T1224 conj inflammatory,immune
R847 T1227 T1222 dobj responses,limits
R848 T1228 T1227 prep to,responses
R849 T1229 T1228 pobj pathogens,to
R850 T1230 T1229 cc and,pathogens
R851 T1231 T1232 compound gut,flora
R852 T1232 T1229 conj flora,pathogens
R853 T1233 T1232 cc and,flora
R854 T1234 T1222 conj prevents,limits
R855 T1235 T1234 dobj damage,prevents
R856 T1236 T1235 prep to,damage
R857 T1237 T1238 det the,host
R858 T1238 T1236 pobj host,to
R859 T1239 T1238 punct (,host
R860 T1240 T1242 compound Moore,al.
R861 T1241 T1242 compound et,al.
R862 T1242 T1238 appos al.,host
R863 T1243 T1242 punct ",",al.
R864 T1244 T1242 appos 2001,al.
R865 T1245 T1238 punct ;,host
R866 T1246 T1238 appos O'Garra,host
R867 T1247 T1246 cc and,O'Garra
R868 T1248 T1246 conj Vieira,O'Garra
R869 T1249 T1248 punct ",",Vieira
R870 T1250 T1248 npadvmod 2004,Vieira
R871 T1251 T1248 punct ),Vieira
R872 T1252 T1234 punct ",",prevents
R873 T1253 T1234 cc but,prevents
R874 T1254 T1255 advmod when,dysregulated
R875 T1255 T1257 nsubj dysregulated,result
R876 T1256 T1257 aux may,result
R877 T1257 T1257 ROOT result,result
R878 T1258 T1257 prep in,result
R879 T1259 T1260 amod chronic,infection
R880 T1260 T1258 pobj infection,in
R881 T1261 T1276 punct (,al.
R882 T1262 T1264 compound Brooks,al.
R883 T1263 T1264 nmod et,al.
R884 T1264 T1276 ccomp al.,al.
R885 T1265 T1264 punct ",",al.
R886 T1266 T1264 npadvmod 2006,al.
R887 T1267 T1276 punct ;,al.
R888 T1268 T1270 compound Ejrnaes,al.
R889 T1269 T1270 compound et,al.
R890 T1270 T1276 ccomp al.,al.
R891 T1271 T1270 punct ",",al.
R892 T1272 T1270 npadvmod 2006,al.
R893 T1273 T1276 punct ;,al.
R894 T1274 T1276 compound Moore,al.
R895 T1275 T1276 nmod et,al.
R896 T1276 T1257 parataxis al.,result
R897 T1277 T1276 punct ",",al.
R898 T1278 T1276 npadvmod 2001,al.
R899 T1279 T1276 punct ),al.
R900 T1280 T1257 punct .,result
R901 T1281 T1283 nsubjpass IL-10,expressed
R902 T1282 T1283 auxpass is,expressed
R903 T1283 T1417 ccomp expressed,al.
R904 T1284 T1283 agent by,expressed
R905 T1285 T1286 compound T,helper
R906 T1286 T1289 nmod helper,Th2
R907 T1287 T1286 nummod 2,helper
R908 T1288 T1289 punct (,Th2
R909 T1289 T1284 pobj Th2,by
R910 T1290 T1289 punct ),Th2
R911 T1291 T1289 conj cells,Th2
R912 T1292 T1289 punct ",",Th2
R913 T1293 T1294 compound B,cells
R914 T1294 T1289 appos cells,Th2
R915 T1295 T1289 punct ",",Th2
R916 T1296 T1289 conj DCs,Th2
R917 T1297 T1296 punct ",",DCs
R918 T1298 T1296 cc and,DCs
R919 T1299 T1296 conj macrophages,DCs
R920 T1300 T1303 punct (,al.
R921 T1301 T1303 compound Moore,al.
R922 T1302 T1303 nmod et,al.
R923 T1303 T1299 parataxis al.,macrophages
R924 T1304 T1303 punct ",",al.
R925 T1305 T1303 npadvmod 2001,al.
R926 T1306 T1303 punct ),al.
R927 T1307 T1299 punct ",",macrophages
R928 T1308 T1299 cc and,macrophages
R929 T1309 T1310 advmod also,by
R930 T1310 T1283 agent by,expressed
R931 T1311 T1312 amod Th1,cells
R932 T1312 T1310 pobj cells,by
R933 T1313 T1316 punct (,al.
R934 T1314 T1316 nmod Anderson,al.
R935 T1315 T1316 nmod et,al.
R936 T1316 T1417 ccomp al.,al.
R937 T1317 T1316 punct ",",al.
R938 T1318 T1316 npadvmod 2007,al.
R939 T1319 T1316 punct ;,al.
R940 T1320 T1322 compound Assenmacher,al.
R941 T1321 T1322 compound et,al.
R942 T1322 T1329 compound al.,al.
R943 T1323 T1322 punct ",",al.
R944 T1324 T1322 npadvmod 1994,al.
R945 T1325 T1322 punct ;,al.
R946 T1326 T1327 compound Del,Prete
R947 T1327 T1329 compound Prete,al.
R948 T1328 T1329 compound et,al.
R949 T1329 T1316 dep al.,al.
R950 T1330 T1329 punct ",",al.
R951 T1331 T1329 npadvmod 1993,al.
R952 T1332 T1417 punct ;,al.
R953 T1333 T1335 compound Gerosa,al.
R954 T1334 T1335 compound et,al.
R955 T1335 T1417 ccomp al.,al.
R956 T1336 T1335 punct ",",al.
R957 T1337 T1335 npadvmod 1996,al.
R958 T1338 T1417 punct ;,al.
R959 T1339 T1341 compound Jankovic,al.
R960 T1340 T1341 compound et,al.
R961 T1341 T1417 ccomp al.,al.
R962 T1342 T1341 punct ",",al.
R963 T1343 T1341 npadvmod 2007,al.
R964 T1344 T1417 punct ;,al.
R965 T1345 T1347 compound Pohl-Koppe,al.
R966 T1346 T1347 compound et,al.
R967 T1347 T1417 ccomp al.,al.
R968 T1348 T1347 punct ",",al.
R969 T1349 T1347 npadvmod 1998,al.
R970 T1350 T1347 punct ),al.
R971 T1351 T1347 cc and,al.
R972 T1352 T1353 punct (,reviewed
R973 T1353 T1388 advcl reviewed,al.
R974 T1354 T1353 prep in,reviewed
R975 T1355 T1354 pobj O'Garra,in
R976 T1356 T1355 cc and,O'Garra
R977 T1357 T1355 conj Vieira,O'Garra
R978 T1358 T1357 punct ",",Vieira
R979 T1359 T1357 npadvmod 2007,Vieira
R980 T1360 T1357 punct ;,Vieira
R981 T1361 T1357 conj Trinchieri,Vieira
R982 T1362 T1361 punct ",",Trinchieri
R983 T1363 T1361 npadvmod 2007,Trinchieri
R984 T1364 T1361 punct ),Trinchieri
R985 T1365 T1388 punct ",",al.
R986 T1366 T1372 amod certain,cells
R987 T1367 T1372 amod regulatory,cells
R988 T1368 T1369 punct (,Treg
R989 T1369 T1367 appos Treg,regulatory
R990 T1370 T1369 punct ),Treg
R991 T1371 T1372 compound T,cells
R992 T1372 T1388 ccomp cells,al.
R993 T1373 T1376 punct (,al.
R994 T1374 T1376 compound Moore,al.
R995 T1375 T1376 nmod et,al.
R996 T1376 T1388 ccomp al.,al.
R997 T1377 T1376 punct ",",al.
R998 T1378 T1376 npadvmod 2001,al.
R999 T1379 T1388 punct ;,al.
R1000 T1380 T1388 ccomp O'Garra,al.
R1001 T1381 T1380 cc and,O'Garra
R1002 T1382 T1380 conj Vieira,O'Garra
R1003 T1383 T1382 punct ",",Vieira
R1004 T1384 T1382 npadvmod 2004,Vieira
R1005 T1385 T1388 punct ;,al.
R1006 T1386 T1388 compound Roncarolo,al.
R1007 T1387 T1388 compound et,al.
R1008 T1388 T1347 conj al.,al.
R1009 T1389 T1388 punct ",",al.
R1010 T1390 T1388 npadvmod 2006,al.
R1011 T1391 T1388 punct ),al.
R1012 T1392 T1388 punct ",",al.
R1013 T1393 T1388 cc and,al.
R1014 T1394 T1395 compound Th17,cells
R1015 T1395 T1388 conj cells,al.
R1016 T1396 T1399 punct (,al.
R1017 T1397 T1399 nmod Awasthi,al.
R1018 T1398 T1399 nmod et,al.
R1019 T1399 T1395 appos al.,cells
R1020 T1400 T1399 punct ",",al.
R1021 T1401 T1399 npadvmod 2007,al.
R1022 T1402 T1417 punct ;,al.
R1023 T1403 T1405 compound Fitzgerald,al.
R1024 T1404 T1405 nmod et,al.
R1025 T1405 T1417 ccomp al.,al.
R1026 T1406 T1405 punct ",",al.
R1027 T1407 T1405 npadvmod 2007,al.
R1028 T1408 T1417 punct ;,al.
R1029 T1409 T1411 compound McGeachy,al.
R1030 T1410 T1411 nmod et,al.
R1031 T1411 T1417 ccomp al.,al.
R1032 T1412 T1411 punct ",",al.
R1033 T1413 T1411 npadvmod 2007,al.
R1034 T1414 T1417 punct ;,al.
R1035 T1415 T1417 compound Stumhofer,al.
R1036 T1416 T1417 nmod et,al.
R1037 T1417 T1417 ROOT al.,al.
R1038 T1418 T1417 punct ",",al.
R1039 T1419 T1417 npadvmod 2007,al.
R1040 T1420 T1417 punct ),al.
R1041 T1421 T1417 punct .,al.
R1042 T1422 T1452 prep In,differentiated
R1043 T1423 T1422 pobj vitro,In
R1044 T1424 T1426 amod human,+
R1045 T1425 T1426 compound CD4,+
R1046 T1426 T1452 advcl +,differentiated
R1047 T1427 T1426 cc and,+
R1048 T1428 T1432 nummod CD8,clones
R1049 T1429 T1432 nummod +,clones
R1050 T1430 T1432 compound T,clones
R1051 T1431 T1432 compound cell,clones
R1052 T1432 T1426 conj clones,+
R1053 T1433 T1432 punct ",",clones
R1054 T1434 T1432 cc or,clones
R1055 T1435 T1439 compound mouse,cells
R1056 T1436 T1439 compound CD4,cells
R1057 T1437 T1439 compound +,cells
R1058 T1438 T1439 compound T,cells
R1059 T1439 T1432 conj cells,clones
R1060 T1440 T1441 nsubj that,produce
R1061 T1441 T1439 relcl produce,cells
R1062 T1442 T1443 preconj both,interferon-γ
R1063 T1443 T1441 dobj interferon-γ,produce
R1064 T1444 T1443 punct (,interferon-γ
R1065 T1445 T1443 appos IFN-γ,interferon-γ
R1066 T1446 T1443 punct ),interferon-γ
R1067 T1447 T1443 cc and,interferon-γ
R1068 T1448 T1443 conj IL-10,interferon-γ
R1069 T1449 T1452 punct ",",differentiated
R1070 T1450 T1452 aux can,differentiated
R1071 T1451 T1452 auxpass be,differentiated
R1072 T1452 T1452 ROOT differentiated,differentiated
R1073 T1453 T1452 agent by,differentiated
R1074 T1454 T1456 compound T,receptor
R1075 T1455 T1456 compound cell,receptor
R1076 T1456 T1453 pobj receptor,by
R1077 T1457 T1458 punct (,TCR
R1078 T1458 T1456 appos TCR,receptor
R1079 T1459 T1458 punct ),TCR
R1080 T1460 T1456 punct -,receptor
R1081 T1461 T1452 conj stimulation,differentiated
R1082 T1462 T1461 prep in,stimulation
R1083 T1463 T1464 det the,presence
R1084 T1464 T1462 pobj presence,in
R1085 T1465 T1464 prep of,presence
R1086 T1466 T1465 pobj IL-12,of
R1087 T1467 T1494 punct (,al.
R1088 T1468 T1470 compound Chang,al.
R1089 T1469 T1470 nmod et,al.
R1090 T1470 T1494 ccomp al.,al.
R1091 T1471 T1470 punct ",",al.
R1092 T1472 T1470 npadvmod 2007,al.
R1093 T1473 T1494 punct ;,al.
R1094 T1474 T1476 compound Gerosa,al.
R1095 T1475 T1476 compound et,al.
R1096 T1476 T1494 ccomp al.,al.
R1097 T1477 T1476 punct ",",al.
R1098 T1478 T1476 npadvmod 1996,al.
R1099 T1479 T1494 punct ;,al.
R1100 T1480 T1482 compound Jeannin,al.
R1101 T1481 T1482 compound et,al.
R1102 T1482 T1494 ccomp al.,al.
R1103 T1483 T1482 punct ",",al.
R1104 T1484 T1482 npadvmod 1996,al.
R1105 T1485 T1494 punct ;,al.
R1106 T1486 T1488 compound Meyaard,al.
R1107 T1487 T1488 compound et,al.
R1108 T1488 T1494 ccomp al.,al.
R1109 T1489 T1488 punct ",",al.
R1110 T1490 T1488 npadvmod 1996,al.
R1111 T1491 T1494 punct ;,al.
R1112 T1492 T1494 compound Windhagen,al.
R1113 T1493 T1494 nmod et,al.
R1114 T1494 T1494 ROOT al.,al.
R1115 T1495 T1494 punct ",",al.
R1116 T1496 T1494 npadvmod 1996,al.
R1117 T1497 T1494 punct ),al.
R1118 T1498 T1494 punct .,al.
R1119 T1499 T1510 advmod Furthermore,isolated
R1120 T1500 T1510 punct ",",isolated
R1121 T1501 T1503 amod Th1,clones
R1122 T1502 T1503 compound cell,clones
R1123 T1503 T1510 nsubjpass clones,isolated
R1124 T1504 T1503 acl coproducing,clones
R1125 T1505 T1504 dobj IFN-γ,coproducing
R1126 T1506 T1505 cc and,IFN-γ
R1127 T1507 T1505 conj IL-10,IFN-γ
R1128 T1508 T1510 aux have,isolated
R1129 T1509 T1510 auxpass been,isolated
R1130 T1510 T1510 ROOT isolated,isolated
R1131 T1511 T1510 prep from,isolated
R1132 T1512 T1513 amod bronchoalveolar,lavage
R1133 T1513 T1511 pobj lavage,from
R1134 T1514 T1513 punct (,lavage
R1135 T1515 T1513 appos BAL,lavage
R1136 T1516 T1513 punct ),lavage
R1137 T1517 T1513 prep of,lavage
R1138 T1518 T1520 amod active,tuberculosis
R1139 T1519 T1520 amod pulmonary,tuberculosis
R1140 T1520 T1517 pobj tuberculosis,of
R1141 T1521 T1520 punct (,tuberculosis
R1142 T1522 T1520 appos TB,tuberculosis
R1143 T1523 T1520 punct ),tuberculosis
R1144 T1524 T1517 pobj patients,of
R1145 T1525 T1528 punct (,al.
R1146 T1526 T1528 nmod Gerosa,al.
R1147 T1527 T1528 nmod et,al.
R1148 T1528 T1510 advmod al.,isolated
R1149 T1529 T1528 punct ",",al.
R1150 T1530 T1528 npadvmod 1999,al.
R1151 T1531 T1528 punct ),al.
R1152 T1532 T1510 punct .,isolated
R1153 T1533 T1534 compound IL-10,production
R1154 T1534 T1540 nsubjpass production,reported
R1155 T1535 T1534 prep by,production
R1156 T1536 T1537 amod Th1,cells
R1157 T1537 T1535 pobj cells,by
R1158 T1538 T1540 auxpass was,reported
R1159 T1539 T1540 advmod also,reported
R1160 T1540 T1594 ccomp reported,al.
R1161 T1541 T1540 prep in,reported
R1162 T1542 T1541 pobj animals,in
R1163 T1543 T1542 acl infected,animals
R1164 T1544 T1543 prep with,infected
R1165 T1545 T1546 compound Toxoplasma,gondii
R1166 T1546 T1544 pobj gondii,with
R1167 T1547 T1546 punct (,gondii
R1168 T1548 T1550 amod Jankovic,al.
R1169 T1549 T1550 nmod et,al.
R1170 T1550 T1546 appos al.,gondii
R1171 T1551 T1550 punct ",",al.
R1172 T1552 T1550 npadvmod 2002,al.
R1173 T1553 T1594 punct ;,al.
R1174 T1554 T1556 compound Shaw,al.
R1175 T1555 T1556 compound et,al.
R1176 T1556 T1594 nmod al.,al.
R1177 T1557 T1556 punct ",",al.
R1178 T1558 T1556 npadvmod 2006,al.
R1179 T1559 T1556 punct ),al.
R1180 T1560 T1561 cc or,with
R1181 T1561 T1556 conj with,al.
R1182 T1562 T1563 compound Leishmania,major
R1183 T1563 T1561 pobj major,with
R1184 T1564 T1567 punct (,al.
R1185 T1565 T1567 nmod Anderson,al.
R1186 T1566 T1567 nmod et,al.
R1187 T1567 T1556 appos al.,al.
R1188 T1568 T1567 punct ",",al.
R1189 T1569 T1567 npadvmod 2007,al.
R1190 T1570 T1567 punct ),al.
R1191 T1571 T1556 cc and,al.
R1192 T1572 T1556 conj shown,al.
R1193 T1573 T1575 aux to,required
R1194 T1574 T1575 auxpass be,required
R1195 T1575 T1572 xcomp required,shown
R1196 T1576 T1575 prep for,required
R1197 T1577 T1576 pobj regulation,for
R1198 T1578 T1577 prep of,regulation
R1199 T1579 T1581 det the,response
R1200 T1580 T1581 amod immune,response
R1201 T1581 T1578 pobj response,of
R1202 T1582 T1581 prep in,response
R1203 T1583 T1584 det these,infections
R1204 T1584 T1582 pobj infections,in
R1205 T1585 T1594 punct (,al.
R1206 T1586 T1588 compound Anderson,al.
R1207 T1587 T1588 nmod et,al.
R1208 T1588 T1594 ccomp al.,al.
R1209 T1589 T1588 punct ",",al.
R1210 T1590 T1588 npadvmod 2007,al.
R1211 T1591 T1594 punct ;,al.
R1212 T1592 T1594 compound Jankovic,al.
R1213 T1593 T1594 nmod et,al.
R1214 T1594 T1594 ROOT al.,al.
R1215 T1595 T1594 punct ",",al.
R1216 T1596 T1594 npadvmod 2007,al.
R1217 T1597 T1594 punct ),al.
R1218 T1598 T1594 punct .,al.
R1219 T1599 T1601 det The,amounts
R1220 T1600 T1601 amod relative,amounts
R1221 T1601 T1611 nsubj amounts,influence
R1222 T1602 T1601 prep of,amounts
R1223 T1603 T1602 pobj IL-10,of
R1224 T1604 T1603 cc and,IL-10
R1225 T1605 T1603 conj IFN-γ,IL-10
R1226 T1606 T1603 acl produced,IL-10
R1227 T1607 T1606 agent by,produced
R1228 T1608 T1609 amod Th1,cells
R1229 T1609 T1607 pobj cells,by
R1230 T1610 T1611 aux may,influence
R1231 T1611 T1611 ROOT influence,influence
R1232 T1612 T1613 det the,balance
R1233 T1613 T1611 dobj balance,influence
R1234 T1614 T1613 prep between,balance
R1235 T1615 T1614 pobj clearance,between
R1236 T1616 T1615 cc and,clearance
R1237 T1617 T1618 amod persistent,infection
R1238 T1618 T1615 conj infection,clearance
R1239 T1619 T1618 prep with,infection
R1240 T1620 T1621 amod certain,pathogens
R1241 T1621 T1619 pobj pathogens,with
R1242 T1622 T1615 punct (,clearance
R1243 T1623 T1625 compound Moore,al.
R1244 T1624 T1625 nmod et,al.
R1245 T1625 T1615 appos al.,clearance
R1246 T1626 T1625 punct ",",al.
R1247 T1627 T1625 appos 2001,al.
R1248 T1628 T1615 punct ;,clearance
R1249 T1629 T1615 conj Trinchieri,clearance
R1250 T1630 T1629 punct ",",Trinchieri
R1251 T1631 T1629 npadvmod 2007,Trinchieri
R1252 T1632 T1629 punct ),Trinchieri
R1253 T1633 T1611 punct ",",influence
R1254 T1634 T1635 advmod thus,determining
R1255 T1635 T1611 advcl determining,influence
R1256 T1636 T1635 advmod whether,determining
R1257 T1637 T1638 amod chronic,infection
R1258 T1638 T1641 nmod infection,ensues
R1259 T1639 T1638 cc or,infection
R1260 T1640 T1638 conj immunopathology,infection
R1261 T1641 T1636 advmod ensues,whether
R1262 T1642 T1611 punct .,influence
R1263 T1643 T1643 ROOT Th1,Th1
R1264 T1644 T1643 punct ",",Th1
R1265 T1645 T1650 nmod Th2,responses
R1266 T1646 T1645 punct ",",Th2
R1267 T1647 T1645 cc and,Th2
R1268 T1648 T1645 conj Th17,Th2
R1269 T1649 T1650 compound cell,responses
R1270 T1650 T1651 nsubj responses,differentiate
R1271 T1651 T1643 relcl differentiate,Th1
R1272 T1652 T1651 prep along,differentiate
R1273 T1653 T1655 amod distinct,pathways
R1274 T1654 T1655 compound signaling,pathways
R1275 T1655 T1652 pobj pathways,along
R1276 T1656 T1665 punct (,al.
R1277 T1657 T1665 nmod Glimcher,al.
R1278 T1658 T1657 cc and,Glimcher
R1279 T1659 T1657 conj Murphy,Glimcher
R1280 T1660 T1659 punct ",",Murphy
R1281 T1661 T1659 npadvmod 2000,Murphy
R1282 T1662 T1659 punct ;,Murphy
R1283 T1663 T1659 conj Ivanov,Murphy
R1284 T1664 T1665 nmod et,al.
R1285 T1665 T1655 appos al.,pathways
R1286 T1666 T1665 punct ",",al.
R1287 T1667 T1665 npadvmod 2007,al.
R1288 T1668 T1665 punct ;,al.
R1289 T1669 T1655 appos Stockinger,pathways
R1290 T1670 T1669 cc and,Stockinger
R1291 T1671 T1669 conj Veldhoen,Stockinger
R1292 T1672 T1671 punct ",",Veldhoen
R1293 T1673 T1671 npadvmod 2007,Veldhoen
R1294 T1674 T1671 punct ),Veldhoen
R1295 T1675 T1651 punct .,differentiate
R1296 T1676 T1678 nummod Th1,development
R1297 T1677 T1678 compound cell,development
R1298 T1678 T1679 nsubj development,requires
R1299 T1679 T1679 ROOT requires,requires
R1300 T1680 T1681 compound signal,transducer
R1301 T1681 T1679 dobj transducer,requires
R1302 T1682 T1681 cc and,transducer
R1303 T1683 T1681 conj activator,transducer
R1304 T1684 T1683 prep of,activator
R1305 T1685 T1684 pobj transcription,of
R1306 T1686 T1685 punct (,transcription
R1307 T1687 T1685 appos STAT,transcription
R1308 T1688 T1685 punct ),transcription
R1309 T1689 T1690 nummod 1,activation
R1310 T1690 T1683 conj activation,activator
R1311 T1691 T1690 punct ",",activation
R1312 T1692 T1690 acl induced,activation
R1313 T1693 T1692 agent by,induced
R1314 T1694 T1693 pobj type,by
R1315 T1695 T1696 nsubj I,IFN
R1316 T1696 T1694 relcl IFN,type
R1317 T1697 T1696 cc or,IFN
R1318 T1698 T1696 conj IFN-γ,IFN
R1319 T1699 T1712 punct ",",signaling
R1320 T1700 T1702 det the,factor
R1321 T1701 T1702 compound transcription,factor
R1322 T1702 T1712 nsubj factor,signaling
R1323 T1703 T1702 appos T-box,factor
R1324 T1704 T1703 nummod 21,T-box
R1325 T1705 T1706 punct (,T-bet
R1326 T1706 T1703 appos T-bet,T-box
R1327 T1707 T1706 punct ),T-bet
R1328 T1708 T1703 punct ",",T-box
R1329 T1709 T1703 cc and,T-box
R1330 T1710 T1703 conj IL-12-induced,T-box
R1331 T1711 T1712 nummod STAT4,signaling
R1332 T1712 T1679 ccomp signaling,requires
R1333 T1713 T1712 punct ",",signaling
R1334 T1714 T1716 nsubj which,couple
R1335 T1715 T1716 aux can,couple
R1336 T1716 T1712 relcl couple,signaling
R1337 T1717 T1716 prep with,couple
R1338 T1718 T1719 compound IL-18-induced,IRAK
R1339 T1719 T1717 pobj IRAK,with
R1340 T1720 T1719 cc and,IRAK
R1341 T1721 T1719 conj NF-κB,IRAK
R1342 T1722 T1723 compound transcription,factors
R1343 T1723 T1716 dobj factors,couple
R1344 T1724 T1725 aux to,drive
R1345 T1725 T1723 relcl drive,factors
R1346 T1726 T1728 det the,amounts
R1347 T1727 T1728 amod high,amounts
R1348 T1728 T1725 dobj amounts,drive
R1349 T1729 T1728 prep of,amounts
R1350 T1730 T1731 amod IFN-γ,required
R1351 T1731 T1728 acl required,amounts
R1352 T1732 T1733 aux to,eradicate
R1353 T1733 T1731 xcomp eradicate,required
R1354 T1734 T1735 amod intracellular,pathogens
R1355 T1735 T1733 dobj pathogens,eradicate
R1356 T1736 T1737 punct (,Glimcher
R1357 T1737 T1716 npadvmod Glimcher,couple
R1358 T1738 T1737 cc and,Glimcher
R1359 T1739 T1737 conj Murphy,Glimcher
R1360 T1740 T1739 punct ",",Murphy
R1361 T1741 T1737 appos 2000,Glimcher
R1362 T1742 T1737 punct ),Glimcher
R1363 T1743 T1712 punct .,signaling
R1364 T1744 T1746 nummod Th2,development
R1365 T1745 T1746 compound cell,development
R1366 T1746 T1758 nsubj development,requires
R1367 T1747 T1746 punct ",",development
R1368 T1748 T1746 prep with,development
R1369 T1749 T1748 pobj expression,with
R1370 T1750 T1749 prep of,expression
R1371 T1751 T1750 pobj IL-4,of
R1372 T1752 T1751 punct ",",IL-4
R1373 T1753 T1751 conj IL-5,IL-4
R1374 T1754 T1753 punct ",",IL-5
R1375 T1755 T1753 cc and,IL-5
R1376 T1756 T1750 pobj IL-13,of
R1377 T1757 T1746 punct ",",development
R1378 T1758 T1758 ROOT requires,requires
R1379 T1759 T1758 dobj IL-4,requires
R1380 T1760 T1759 punct ",",IL-4
R1381 T1761 T1759 conj STAT6,IL-4
R1382 T1762 T1761 punct ",",STAT6
R1383 T1763 T1761 cc and,STAT6
R1384 T1764 T1766 det the,factor
R1385 T1765 T1766 compound transcription,factor
R1386 T1766 T1773 nsubj factor,-3
R1387 T1767 T1769 nmod GATA,protein
R1388 T1768 T1769 amod binding,protein
R1389 T1769 T1766 appos protein,factor
R1390 T1770 T1769 punct (,protein
R1391 T1771 T1769 appos GATA,protein
R1392 T1772 T1769 punct ),protein
R1393 T1773 T1759 appos -3,IL-4
R1394 T1774 T1775 punct (,Glimcher
R1395 T1775 T1773 appos Glimcher,-3
R1396 T1776 T1775 cc and,Glimcher
R1397 T1777 T1775 conj Murphy,Glimcher
R1398 T1778 T1777 punct ",",Murphy
R1399 T1779 T1775 appos 2000,Glimcher
R1400 T1780 T1775 punct ),Glimcher
R1401 T1781 T1758 punct .,requires
R1402 T1782 T1783 det The,development
R1403 T1783 T1787 nsubj development,requires
R1404 T1784 T1783 prep of,development
R1405 T1785 T1786 compound Th17,cells
R1406 T1786 T1784 pobj cells,of
R1407 T1787 T1787 ROOT requires,requires
R1408 T1788 T1787 dobj IL-6,requires
R1409 T1789 T1788 punct ",",IL-6
R1410 T1790 T1788 conj TGF-β,IL-6
R1411 T1791 T1790 punct ",",TGF-β
R1412 T1792 T1790 cc and,TGF-β
R1413 T1793 T1795 det the,expression
R1414 T1794 T1795 amod STAT3-dependent,expression
R1415 T1795 T1790 conj expression,TGF-β
R1416 T1796 T1795 prep of,expression
R1417 T1797 T1799 det the,factor
R1418 T1825 T1824 pcomp varying,by
R1419 T1798 T1799 compound transcription,factor
R1420 T1826 T1827 det the,dose
R1421 T1799 T1796 pobj factor,of
R1422 T1827 T1825 dobj dose,varying
R1423 T1828 T1827 prep of,dose
R1424 T1800 T1804 nmod RORγt,al.
R1425 T1829 T1828 pobj antigen,of
R1426 T1830 T1827 acl presented,dose
R1427 T1801 T1804 punct (,al.
R1428 T1831 T1830 dative to,presented
R1429 T1832 T1835 det the,cell
R1430 T1833 T1835 amod naive,cell
R1431 T1834 T1835 compound T,cell
R1432 T1835 T1831 pobj cell,to
R1433 T1836 T1835 prep by,cell
R1434 T1802 T1804 compound Ivanov,al.
R1435 T1837 T1839 det the,cell
R1436 T1838 T1839 amod antigen-presenting,cell
R1437 T1839 T1836 pobj cell,by
R1438 T1840 T1839 punct (,cell
R1439 T1803 T1804 nmod et,al.
R1440 T1841 T1839 appos APC,cell
R1441 T1804 T1795 appos al.,expression
R1442 T1805 T1804 punct ",",al.
R1443 T1842 T1839 punct ),cell
R1444 T1843 T1823 punct .,induced
R1445 T1806 T1804 npadvmod 2007,al.
R1446 T1844 T1868 mark Whereas,result
R1447 T1845 T1846 amod high,doses
R1448 T1846 T1868 nsubj doses,result
R1449 T1807 T1804 punct ;,al.
R1450 T1847 T1846 prep of,doses
R1451 T1848 T1847 pobj antigen,of
R1452 T1808 T1804 conj Stockinger,al.
R1453 T1849 T1868 punct ",",result
R1454 T1850 T1868 prep with,result
R1455 T1851 T1853 amod sustained,signaling
R1456 T1809 T1808 cc and,Stockinger
R1457 T1852 T1853 compound TCR,signaling
R1458 T1853 T1850 pobj signaling,with
R1459 T1810 T1808 conj Veldhoen,Stockinger
R1460 T1854 T1853 cc and,signaling
R1461 T1855 T1853 conj extracellular-signal,signaling
R1462 T1811 T1810 punct ",",Veldhoen
R1463 T1812 T1810 npadvmod 2007,Veldhoen
R1464 T1813 T1810 punct ),Veldhoen
R1465 T1856 T1855 acl regulated,extracellular-signal
R1466 T1814 T1787 punct .,requires
R1467 T1857 T1855 punct (,extracellular-signal
R1468 T1815 T1819 nummod Th1,responses
R1469 T1858 T1855 appos ERK,extracellular-signal
R1470 T1816 T1815 cc and,Th1
R1471 T1859 T1855 punct ),extracellular-signal
R1472 T1860 T1861 amod mitogen-activated,protein
R1473 T1817 T1815 conj Th2,Th1
R1474 T1861 T1868 nsubj protein,result
R1475 T1862 T1861 amod kinase,protein
R1476 T1863 T1864 punct (,MAPK
R1477 T1818 T1819 compound cell,responses
R1478 T1864 T1862 appos MAPK,kinase
R1479 T1865 T1864 punct ),MAPK
R1480 T1866 T1862 conj phosphorylation,kinase
R1481 T1819 T1823 nsubjpass responses,induced
R1482 T1867 T1866 punct ",",phosphorylation
R1483 T1868 T1891 advcl result,favor
R1484 T1869 T1868 prep in,result
R1485 T1870 T1871 amod Th1,cells
R1486 T1871 T1869 pobj cells,in
R1487 T1872 T1871 acl producing,cells
R1488 T1820 T1823 aux can,induced
R1489 T1873 T1872 dobj IFN-γ,producing
R1490 T1874 T1868 prep via,result
R1491 T1875 T1877 det an,mechanism
R1492 T1821 T1823 advmod also,induced
R1493 T1876 T1877 compound IL-12-independent,mechanism
R1494 T1877 T1874 pobj mechanism,via
R1495 T1878 T1877 punct ",",mechanism
R1496 T1879 T1880 amod low,doses
R1497 T1822 T1823 auxpass be,induced
R1498 T1880 T1877 conj doses,mechanism
R1499 T1881 T1880 prep of,doses
R1500 T1882 T1881 pobj antigen,of
R1501 T1823 T1823 ROOT induced,induced
R1502 T1883 T1868 punct ",",result
R1503 T1884 T1868 prep with,result
R1504 T1885 T1891 nmod transient,favor
R1505 T1824 T1823 agent by,induced
R1506 T1886 T1885 nummod ERK1,transient
R1507 T1887 T1885 cc and,transient
R1508 T1888 T1889 nummod ERK2,activation
R1509 T1922 T1918 punct .,al.
R1510 T1889 T1885 conj activation,transient
R1511 T1890 T1891 punct ",",favor
R1512 T1891 T1918 ccomp favor,al.
R1513 T1923 T1928 mark Because,cross
R1514 T1892 T1893 amod Th2,responses
R1515 T1893 T1891 dobj responses,favor
R1516 T1924 T1927 nmod Th1,cells
R1517 T1925 T1924 cc and,Th1
R1518 T1894 T1893 cc and,responses
R1519 T1895 T1896 compound IL-4,secretion
R1520 T1926 T1924 conj Th2,Th1
R1521 T1896 T1893 conj secretion,responses
R1522 T1897 T1912 punct (,al.
R1523 T1927 T1928 nsubj cells,cross
R1524 T1928 T1973 advcl cross,act
R1525 T1898 T1900 amod Constant,al.
R1526 T1929 T1928 conj regulate,cross
R1527 T1930 T1931 det each,other
R1528 T1899 T1900 nmod et,al.
R1529 T1900 T1912 ccomp al.,al.
R1530 T1901 T1900 punct ",",al.
R1531 T1902 T1900 npadvmod 1995,al.
R1532 T1903 T1912 punct ;,al.
R1533 T1904 T1906 compound Hosken,al.
R1534 T1905 T1906 compound et,al.
R1535 T1931 T1933 poss other,development
R1536 T1906 T1912 ccomp al.,al.
R1537 T1907 T1906 punct ",",al.
R1538 T1908 T1906 npadvmod 1995,al.
R1539 T1932 T1931 case 's,other
R1540 T1909 T1912 punct ;,al.
R1541 T1910 T1912 compound Jorritsma,al.
R1542 T1911 T1912 compound et,al.
R1543 T1912 T1896 parataxis al.,secretion
R1544 T1933 T1929 dobj development,regulate
R1545 T1913 T1912 punct ",",al.
R1546 T1914 T1912 npadvmod 2003,al.
R1547 T1915 T1918 punct ;,al.
R1548 T1934 T1933 cc and,development
R1549 T1916 T1918 compound Yamane,al.
R1550 T1917 T1918 compound et,al.
R1551 T1918 T1918 ROOT al.,al.
R1552 T1935 T1933 conj function,development
R1553 T1919 T1918 punct ",",al.
R1554 T1920 T1918 npadvmod 2005,al.
R1555 T1921 T1918 punct ),al.
R1556 T1936 T1929 cc and,regulate
R1557 T1937 T1938 aux can,suppress
R1558 T1938 T1929 conj suppress,regulate
R1559 T1939 T1941 compound Th17,responses
R1560 T1940 T1941 compound cell,responses
R1561 T1953 T1951 conj Murphy,Glimcher
R1562 T1954 T1953 punct ",",Murphy
R1563 T1941 T1938 dobj responses,suppress
R1564 T1955 T1953 npadvmod 2000,Murphy
R1565 T1956 T1953 punct ;,Murphy
R1566 T1942 T1938 punct ",",suppress
R1567 T1957 T1953 conj Stockinger,Murphy
R1568 T1958 T1957 cc and,Stockinger
R1569 T1959 T1957 conj Veldhoen,Stockinger
R1570 T1943 T1938 cc and,suppress
R1571 T1960 T1959 punct ",",Veldhoen
R1572 T1944 T1945 det all,differentiate
R1573 T1961 T1959 npadvmod 2007,Veldhoen
R1574 T1962 T1959 punct ),Veldhoen
R1575 T1963 T1973 punct ",",act
R1576 T1964 T1973 nsubj IL-10,act
R1577 T1945 T1938 conj differentiate,suppress
R1578 T1965 T1964 acl produced,IL-10
R1579 T1966 T1965 agent by,produced
R1580 T1946 T1945 prep along,differentiate
R1581 T1967 T1970 predet all,cells
R1582 T1968 T1970 det these,cells
R1583 T1969 T1970 compound Th,cells
R1584 T1970 T1966 pobj cells,by
R1585 T1971 T1973 aux may,act
R1586 T1972 T1973 advmod thus,act
R1587 T1947 T1949 amod distinct,pathways
R1588 T1973 T1973 ROOT act,act
R1589 T1974 T1973 prep as,act
R1590 T1975 T1977 det a,regulator
R1591 T1948 T1949 compound signaling,pathways
R1592 T1976 T1977 compound feedback,regulator
R1593 T1977 T1974 pobj regulator,as
R1594 T1949 T1946 pobj pathways,along
R1595 T1950 T1973 punct (,act
R1596 T1951 T1973 nsubj Glimcher,act
R1597 T1978 T1979 aux to,control
R1598 T1979 T1977 relcl control,regulator
R1599 T1952 T1951 cc and,Glimcher
R1600 T1980 T1981 det the,pathology
R1601 T1981 T1979 dobj pathology,control
R1602 T1982 T1981 acl associated,pathology
R1603 T2050 T2015 punct .,showed
R1604 T1983 T1982 prep with,associated
R1605 T1984 T1985 det an,overexuberant
R1606 T2051 T2054 advmod Furthermore,showed
R1607 T1985 T1983 pobj overexuberant,with
R1608 T1986 T1985 punct ",",overexuberant
R1609 T1987 T1991 advmod albeit,response
R1610 T1988 T1991 amod efficacious,response
R1611 T2052 T2054 punct ",",showed
R1612 T1989 T1991 punct ",",response
R1613 T1990 T1991 amod inflammatory,response
R1614 T1991 T1985 appos response,overexuberant
R1615 T2053 T2054 nsubj we,showed
R1616 T1992 T1973 punct .,act
R1617 T1993 T2003 mark Whether,induced
R1618 T1994 T1995 amod IL-10,production
R1619 T2054 T2054 ROOT showed,showed
R1620 T1995 T2003 nsubjpass production,induced
R1621 T1996 T1995 prep by,production
R1622 T2055 T2061 mark that,is
R1623 T1997 T2001 det these,subsets
R1624 T1998 T2001 amod different,subsets
R1625 T2056 T2061 nsubj activation,is
R1626 T1999 T2000 compound Th,cell
R1627 T2000 T2001 compound cell,subsets
R1628 T2001 T1996 pobj subsets,by
R1629 T2002 T2003 auxpass is,induced
R1630 T2057 T2056 prep of,activation
R1631 T2003 T2009 csubj induced,is
R1632 T2004 T2003 agent by,induced
R1633 T2005 T2008 amod independent,mechanisms
R1634 T2006 T2005 cc and/or,independent
R1635 T2007 T2005 conj common,independent
R1636 T2008 T2004 pobj mechanisms,by
R1637 T2009 T2009 ROOT is,is
R1638 T2058 T2057 pobj ERK1,of
R1639 T2010 T2009 acomp unknown,is
R1640 T2011 T2009 punct .,is
R1641 T2059 T2058 cc and,ERK1
R1642 T2012 T2015 advmod Here,showed
R1643 T2013 T2015 punct ",",showed
R1644 T2014 T2015 nsubj we,showed
R1645 T2015 T2015 ROOT showed,showed
R1646 T2060 T2058 conj ERK2,ERK1
R1647 T2016 T2030 mark that,required
R1648 T2017 T2030 prep in,required
R1649 T2018 T2019 amod vitro,differentiation
R1650 T2019 T2017 pobj differentiation,in
R1651 T2061 T2054 ccomp is,showed
R1652 T2020 T2019 prep of,differentiation
R1653 T2021 T2023 amod IL-10-producing,cells
R1654 T2022 T2023 amod Th1,cells
R1655 T2062 T2063 det a,requirement
R1656 T2023 T2020 pobj cells,of
R1657 T2024 T2023 prep from,cells
R1658 T2063 T2061 attr requirement,is
R1659 T2025 T2029 amod naive,cells
R1660 T2026 T2029 compound CD4,cells
R1661 T2027 T2029 nummod +,cells
R1662 T2064 T2063 prep for,requirement
R1663 T2028 T2029 compound T,cells
R1664 T2029 T2024 pobj cells,from
R1665 T2030 T2015 ccomp required,showed
R1666 T2065 T2064 pobj production,for
R1667 T2031 T2033 npadvmod IL-12-induced,signaling
R1668 T2032 T2033 nummod STAT4,signaling
R1669 T2033 T2030 dobj signaling,required
R1670 T2034 T2033 punct ",",signaling
R1671 T2066 T2065 prep of,production
R1672 T2035 T2037 amod strong,activation
R1673 T2036 T2037 compound TCR,activation
R1674 T2067 T2066 pobj IL-10,of
R1675 T2037 T2033 appos activation,signaling
R1676 T2038 T2037 punct (,activation
R1677 T2039 T2040 amod high,antigen
R1678 T2068 T2063 prep by,requirement
R1679 T2040 T2041 compound antigen,dose
R1680 T2041 T2037 appos dose,activation
R1681 T2042 T2037 punct ),activation
R1682 T2043 T2030 punct ",",required
R1683 T2044 T2030 cc and,required
R1684 T2045 T2030 conj sustained,required
R1685 T2046 T2045 dobj ERK1,sustained
R1686 T2069 T2076 nmod Th1,subsets
R1687 T2047 T2046 cc and,ERK1
R1688 T2048 T2049 nummod ERK2,phosphorylation
R1689 T2049 T2046 conj phosphorylation,ERK1
R1690 T2070 T2069 punct ",",Th1
R1691 T2071 T2069 conj Th2,Th1
R1692 T2072 T2071 punct ",",Th2
R1693 T2073 T2071 cc and,Th2
R1694 T2074 T2076 compound Th17,subsets
R1695 T2075 T2076 compound cell,subsets
R1696 T2076 T2068 pobj subsets,by
R1697 T2077 T2054 punct .,showed
R1698 T2078 T2083 det This,pathway
R1699 T2079 T2083 amod common,pathway
R1700 T2080 T2079 cc but,common
R1701 T2081 T2082 advmod highly,regulated
R1702 T2082 T2079 conj regulated,common
R1703 T2083 T2089 nsubj pathway,ensures
R1704 T2084 T2083 prep for,pathway
R1705 T2085 T2086 compound IL-10,induction
R1706 T2086 T2084 pobj induction,for
R1707 T2087 T2086 cc and,induction
R1708 T2088 T2086 conj maintenance,induction
R1709 T2089 T2089 ROOT ensures,ensures
R1710 T2090 T2091 poss its,function
R1711 T2091 T2089 dobj function,ensures
R1712 T2092 T2089 prep as,ensures
R1713 T2093 T2095 det a,loop
R1714 T2094 T2095 compound feedback,loop
R1715 T2095 T2092 pobj loop,as
R1716 T2096 T2097 aux to,control
R1717 T2097 T2095 relcl control,loop
R1718 T2098 T2097 dobj damage,control
R1719 T2099 T2098 prep to,damage
R1720 T2100 T2101 det the,host
R1721 T2101 T2099 pobj host,to
R1722 T2102 T2089 cc and,ensures
R1723 T2103 T2104 advmod also,allows
R1724 T2104 T2089 conj allows,ensures
R1725 T2105 T2107 det a,response
R1726 T2106 T2107 amod protective,response
R1727 T2107 T2109 nsubj response,ensue
R1728 T2108 T2109 aux to,ensue
R1729 T2109 T2104 ccomp ensue,allows
R1730 T2110 T2111 mark as,opposed
R1731 T2111 T2109 advcl opposed,ensue
R1732 T2112 T2111 prep to,opposed
R1733 T2113 T2114 amod chronic,infection
R1734 T2114 T2112 pobj infection,to
R1735 T2115 T2089 punct .,ensures
R2726 T3574 T3589 nsubj IL-12,study
R2727 T3575 T3574 cc and,IL-12
R2728 T3576 T3577 amod High,Doses
R2729 T3577 T3574 conj Doses,IL-12
R2730 T3578 T3577 prep of,Doses
R2731 T3579 T3580 compound Antigen,Induce
R2732 T3580 T3578 pobj Induce,of
R2733 T3581 T3582 det the,Development
R2734 T3582 T3580 appos Development,Induce
R2735 T3583 T3582 prep of,Development
R2736 T3584 T3587 compound Th1,IL-10
R2737 T3585 T3586 compound Cells,Producing
R2738 T3586 T3587 compound Producing,IL-10
R2739 T3587 T3583 pobj IL-10,of
R2740 T3588 T3589 aux To,study
R2741 T3589 T3601 ccomp study,cultured
R2742 T3590 T3591 det the,differentiation
R2743 T3591 T3589 dobj differentiation,study
R2744 T3592 T3591 prep of,differentiation
R2745 T3593 T3594 amod Th1,cells
R2746 T3594 T3592 pobj cells,of
R2747 T3595 T3589 advcl coproducing,study
R2748 T3596 T3595 dobj IFN-γ,coproducing
R2749 T3597 T3596 cc and,IFN-γ
R2750 T3598 T3596 conj IL-10,IFN-γ
R2751 T3599 T3601 punct ",",cultured
R2752 T3600 T3601 nsubj we,cultured
R2753 T3601 T3601 ROOT cultured,cultured
R2754 T3602 T3610 amod purified,cells
R2755 T3603 T3610 amod TCR-transgenic,cells
R2756 T3604 T3610 nmod DO11,cells
R2757 T3605 T3604 nummod .10,DO11
R2758 T3606 T3610 amod naive,cells
R2759 T3607 T3610 compound CD4,cells
R2760 T3608 T3610 nummod +,cells
R2761 T3609 T3610 compound T,cells
R2762 T3610 T3601 dobj cells,cultured
R2763 T3611 T3610 prep with,cells
R2764 T3612 T3613 amod purified,DCs
R2765 T3613 T3611 pobj DCs,with
R2766 T3614 T3601 prep as,cultured
R2767 T3615 T3614 pobj APCs,as
R2768 T3616 T3615 cc and,APCs
R2769 T3617 T3618 amod increasing,doses
R2770 T3618 T3615 conj doses,APCs
R2771 T3619 T3618 prep of,doses
R2772 T3620 T3621 compound ovalbumin,peptide
R2773 T3621 T3619 pobj peptide,of
R2774 T3622 T3621 nummod 323-339,peptide
R2775 T3623 T3624 punct (,OVA
R2776 T3624 T3621 appos OVA,peptide
R2777 T3625 T3601 punct ),cultured
R2778 T3626 T3601 punct .,cultured
R2779 T3627 T3636 nsubj Culture,gave
R2780 T3628 T3627 prep with,Culture
R2781 T3629 T3630 amod high,doses
R2782 T3630 T3628 pobj doses,with
R2783 T3631 T3630 prep of,doses
R2784 T3632 T3631 pobj antigen,of
R2785 T3633 T3627 prep for,Culture
R2786 T3634 T3635 nummod 7,days
R2787 T3635 T3633 pobj days,for
R2788 T3636 T3636 ROOT gave,gave
R2789 T3637 T3636 dobj rise,gave
R2790 T3638 T3637 prep to,rise
R2791 T3639 T3640 nummod Th1,cells
R2792 T3640 T3638 pobj cells,to
R2793 T3641 T3640 acl expressing,cells
R2794 T3642 T3641 dobj IFN-γ,expressing
R2795 T3643 T3641 prep upon,expressing
R2796 T3644 T3643 pobj restimulation,upon
R2797 T3645 T3648 punct (,al.
R2798 T3646 T3648 amod Constant,al.
R2799 T3647 T3648 nmod et,al.
R2800 T3648 T3640 appos al.,cells
R2801 T3649 T3648 punct ",",al.
R2802 T3650 T3648 npadvmod 1995,al.
R2803 T3651 T3638 punct ;,to
R2804 T3652 T3654 compound Hosken,al.
R2805 T3653 T3654 compound et,al.
R2806 T3654 T3637 appos al.,rise
R2807 T3655 T3654 punct ",",al.
R2808 T3656 T3654 npadvmod 1995,al.
R2809 T3657 T3637 punct ),rise
R2810 T3658 T3636 punct ",",gave
R2811 T3659 T3636 cc but,gave
R2812 T3660 T3664 neg not,S1A
R2813 T3661 T3664 nmod IL-10,S1A
R2814 T3662 T3664 punct (,S1A
R2815 T3663 T3664 compound Figure,S1A
R2816 T3664 T3636 conj S1A,gave
R2817 T3665 T3666 amod available,online
R2818 T3666 T3664 appos online,S1A
R2819 T3667 T3664 punct ),S1A
R2820 T3668 T3664 punct .,S1A
R2821 T3669 T3678 nsubj Culture,led
R2822 T3670 T3669 prep with,Culture
R2823 T3671 T3673 amod low,doses
R2824 T3672 T3673 compound antigen,doses
R2825 T3673 T3670 pobj doses,with
R2826 T3674 T3673 prep under,doses
R2827 T3675 T3677 det the,conditions
R2828 T3676 T3677 amod same,conditions
R2829 T3677 T3674 pobj conditions,under
R2830 T3678 T3678 ROOT led,led
R2831 T3679 T3678 prep to,led
R2832 T3680 T3681 det the,differentiation
R2833 T3681 T3679 pobj differentiation,to
R2834 T3682 T3681 prep of,differentiation
R2835 T3683 T3684 amod Th2,cells
R2836 T3684 T3682 pobj cells,of
R2837 T3685 T3681 punct ",",differentiation
R2838 T3686 T3687 nsubj which,expressed
R2839 T3687 T3681 relcl expressed,differentiation
R2840 T3688 T3689 det both,IL-4
R2841 T3689 T3687 dobj IL-4,expressed
R2842 T3690 T3689 cc and,IL-4
R2843 T3691 T3689 conj IL-10,IL-4
R2844 T3692 T3687 prep upon,expressed
R2845 T3693 T3692 pobj restimulation,upon
R2846 T3694 T3695 punct (,Figure
R2847 T3695 T3693 appos Figure,restimulation
R2848 T3696 T3695 nummod S1A,Figure
R2849 T3697 T3695 punct ),Figure
R2850 T3698 T3678 punct .,led
R2851 T3699 T3722 nsubj Culture,resulted
R2852 T3700 T3699 prep of,Culture
R2853 T3701 T3705 amod naive,cells
R2854 T3702 T3705 compound CD4,cells
R2855 T3703 T3705 nummod +,cells
R2856 T3704 T3705 compound T,cells
R2857 T3705 T3700 pobj cells,of
R2858 T3706 T3699 prep in,Culture
R2859 T3707 T3709 det an,system
R2860 T3708 T3709 amod APC-free,system
R2861 T3709 T3706 pobj system,in
R2862 T3710 T3709 prep by,system
R2863 T3711 T3710 pobj stimulation,by
R2864 T3712 T3709 prep with,system
R2865 T3713 T3716 amod anti-CD3,antibodies
R2866 T3714 T3713 cc and,anti-CD3
R2867 T3715 T3713 conj anti-CD28,anti-CD3
R2868 T3716 T3712 pobj antibodies,with
R2869 T3717 T3699 prep in,Culture
R2870 T3718 T3719 det the,presence
R2871 T3719 T3717 pobj presence,in
R2872 T3720 T3719 prep of,presence
R2873 T3721 T3720 pobj IL-12,of
R2874 T3722 T3722 ROOT resulted,resulted
R2875 T3723 T3722 prep in,resulted
R2876 T3724 T3726 amod IFN-γ-producing,cells
R2877 T3725 T3726 amod Th1,cells
R2878 T3726 T3723 pobj cells,in
R2879 T3727 T3722 punct ",",resulted
R2880 T3728 T3729 det a,proportion
R2881 T3729 T3736 nsubj proportion,did
R2882 T3730 T3729 prep of,proportion
R2883 T3731 T3730 pobj which,of
R2884 T3732 T3733 compound coproduced,IL-10
R2885 T3733 T3729 appos IL-10,proportion
R2886 T3734 T3736 punct ",",did
R2887 T3735 T3736 mark as,did
R2888 T3736 T3722 conj did,resulted
R2889 T3737 T3738 nummod Th2,cells
R2890 T3738 T3736 dobj cells,did
R2891 T3739 T3738 acl resulting,cells
R2892 T3740 T3739 prep from,resulting
R2893 T3741 T3740 pobj culture,from
R2894 T3742 T3741 prep in,culture
R2895 T3743 T3742 pobj IL-4,in
R2896 T3744 T3745 punct (,Figure
R2897 T3745 T3741 appos Figure,culture
R2898 T3746 T3745 nummod S1B,Figure
R2899 T3747 T3736 punct ),did
R2900 T3748 T3736 punct .,did
R2901 T3749 T3750 aux To,investigate
R2902 T3750 T3778 advcl investigate,cultured
R2903 T3751 T3760 mark whether,resulted
R2904 T3752 T3753 det the,lack
R2905 T3753 T3760 nsubj lack,resulted
R2906 T3754 T3753 prep of,lack
R2907 T3755 T3754 pobj IL-10,of
R2908 T3756 T3755 acl produced,IL-10
R2909 T3757 T3756 agent by,produced
R2910 T3758 T3759 amod Th1,cells
R2911 T3759 T3757 pobj cells,by
R2912 T3760 T3750 ccomp resulted,investigate
R2913 T3761 T3760 prep from,resulted
R2914 T3762 T3761 pobj inhibition,from
R2915 T3763 T3762 prep of,inhibition
R2916 T3764 T3765 compound IL-10,production
R2917 T3765 T3763 pobj production,of
R2918 T3766 T3765 prep by,production
R2919 T3767 T3766 pobj DCs,by
R2920 T3768 T3767 cc and,DCs
R2921 T3769 T3770 amod high,antigen
R2922 T3770 T3771 compound antigen,dose
R2923 T3771 T3765 conj dose,production
R2924 T3772 T3760 cc or,resulted
R2925 T3773 T3774 advmod alternatively,required
R2926 T3774 T3760 conj required,resulted
R2927 T3775 T3774 dobj IL-12,required
R2928 T3776 T3778 punct ",",cultured
R2929 T3777 T3778 nsubj we,cultured
R2930 T3778 T3778 ROOT cultured,cultured
R2931 T3779 T3783 amod naive,cells
R2932 T3780 T3783 compound CD4,cells
R2933 T3781 T3783 nummod +,cells
R2934 T3782 T3783 compound T,cells
R2935 T3783 T3778 dobj cells,cultured
R2936 T3784 T3778 prep with,cultured
R2937 T3785 T3786 amod increasing,doses
R2938 T3786 T3784 pobj doses,with
R2939 T3787 T3786 prep of,doses
R2940 T3788 T3787 pobj antigen,of
R2941 T3789 T3788 acl presented,antigen
R2942 T3790 T3789 agent by,presented
R2943 T3791 T3790 pobj DC,by
R2944 T3792 T3789 prep in,presented
R2945 T3793 T3794 det the,presence
R2946 T3794 T3792 pobj presence,in
R2947 T3795 T3794 prep of,presence
R2948 T3796 T3795 pobj IL-12,of
R2949 T3797 T3778 punct .,cultured
R2950 T3798 T3805 prep At,abrogated
R2951 T3799 T3800 amod low,doses
R2952 T3800 T3798 pobj doses,At
R2953 T3801 T3800 prep of,doses
R2954 T3802 T3801 pobj antigen,of
R2955 T3803 T3805 punct ",",abrogated
R2956 T3804 T3805 nsubj IL-12,abrogated
R2957 T3805 T3805 ROOT abrogated,abrogated
R2958 T3806 T3807 det the,development
R2959 T3807 T3805 dobj development,abrogated
R2960 T3808 T3807 prep of,development
R2961 T3809 T3810 amod Th2,cells
R2962 T3810 T3808 pobj cells,of
R2963 T3811 T3805 cc and,abrogated
R2964 T3812 T3805 conj induced,abrogated
R2965 T3813 T3814 amod IFN-γ,expression
R2966 T3814 T3812 dobj expression,induced
R2967 T3815 T3812 cc but,induced
R2968 T3816 T3818 advmod only,levels
R2969 T3817 T3818 amod low,levels
R2970 T3818 T3812 conj levels,induced
R2971 T3819 T3818 prep of,levels
R2972 T3820 T3821 compound IL-10,expression
R2973 T3821 T3819 pobj expression,of
R2974 T3822 T3812 punct ",",induced
R2975 T3823 T3812 advcl suggesting,induced
R2976 T3824 T3828 mark that,was
R2977 T3825 T3827 amod IL-12,se
R2978 T3826 T3827 advmod per,se
R2979 T3827 T3828 nsubj se,was
R2980 T3828 T3823 ccomp was,suggesting
R2981 T3829 T3828 neg not,was
R2982 T3830 T3828 acomp sufficient,was
R2983 T3831 T3832 aux to,induce
R2984 T3832 T3830 xcomp induce,sufficient
R2985 T3833 T3835 amod significant,production
R2986 T3834 T3835 compound IL-10,production
R2987 T3835 T3832 dobj production,induce
R2988 T3836 T3835 prep in,production
R2989 T3837 T3838 amod Th1,cells
R2990 T3838 T3836 pobj cells,in
R2991 T3839 T3840 punct (,Figure
R2992 T3840 T3835 appos Figure,production
R2993 T3841 T3840 nummod 1A,Figure
R2994 T3842 T3840 punct ),Figure
R2995 T3843 T3805 punct .,abrogated
R2996 T3844 T3855 advmod Strikingly,driven
R2997 T3845 T3855 punct ",",driven
R2998 T3846 T3851 mark as,increased
R2999 T3847 T3849 det the,dose
R3000 T3848 T3849 compound antigen,dose
R3001 T3849 T3851 nsubjpass dose,increased
R3002 T3850 T3851 auxpass was,increased
R3003 T3851 T3855 advcl increased,driven
R3004 T3852 T3855 punct ",",driven
R3005 T3853 T3854 amod Th1,populations
R3006 T3854 T3855 nsubj populations,driven
R3007 T3855 T3855 ROOT driven,driven
R3008 T3856 T3855 prep with,driven
R3009 T3857 T3856 pobj IL-12,with
R3010 T3858 T3855 advmod now,driven
R3011 T3859 T3855 conj contained,driven
R3012 T3860 T3861 amod higher,numbers
R3013 T3861 T3859 dobj numbers,contained
R3014 T3862 T3861 prep of,numbers
R3015 T3863 T3864 amod IL-10-producing,cells
R3016 T3864 T3862 pobj cells,of
R3017 T3865 T3866 punct (,Figure
R3018 T3866 T3861 appos Figure,numbers
R3019 T3867 T3866 nummod 1A,Figure
R3020 T3868 T3866 punct ),Figure
R3021 T3869 T3859 cc and,contained
R3022 T3870 T3859 conj produced,contained
R3023 T3871 T3873 amod more,protein
R3024 T3872 T3873 amod IL-10,protein
R3025 T3873 T3870 dobj protein,produced
R3026 T3874 T3873 prep upon,protein
R3027 T3875 T3874 pobj restimulation,upon
R3028 T3876 T3878 punct (,1A
R3029 T3877 T3878 compound Figures,1A
R3030 T3878 T3873 appos 1A,protein
R3031 T3879 T3878 cc and,1A
R3032 T3880 T3878 conj 1B,1A
R3033 T3881 T3878 punct ),1A
R3034 T3882 T3855 punct .,driven
R3035 T3883 T3892 advmod Thus,required
R3036 T3884 T3892 punct ",",required
R3037 T3885 T3886 det the,development
R3038 T3886 T3892 nsubj development,required
R3039 T3887 T3886 prep of,development
R3040 T3888 T3889 amod Th1,cells
R3041 T3889 T3887 pobj cells,of
R3042 T3890 T3889 acl producing,cells
R3043 T3891 T3890 dobj IL-10,producing
R3044 T3892 T3892 ROOT required,required
R3045 T3893 T3894 preconj both,IL-12
R3046 T3894 T3892 dobj IL-12,required
R3047 T3895 T3894 cc and,IL-12
R3048 T3962 T3959 pobj cells,of
R3049 T3896 T3897 amod high,doses
R3050 T3963 T3953 conj is,showed
R3051 T3897 T3894 conj doses,IL-12
R3052 T3898 T3897 prep of,doses
R3053 T3964 T3965 advmod most,likely
R3054 T3899 T3898 pobj antigen,of
R3055 T3900 T3892 punct .,required
R3056 T3965 T3963 acomp likely,is
R3057 T3901 T3902 nummod Th1,cells
R3058 T3902 T3913 nsubj cells,lost
R3059 T3903 T3902 acl differentiated,cells
R3060 T3966 T3967 neg not,related
R3061 T3904 T3905 aux to,produce
R3062 T3905 T3903 advcl produce,differentiated
R3063 T3906 T3907 amod large,amounts
R3064 T3967 T3963 acomp related,is
R3065 T3907 T3905 dobj amounts,produce
R3066 T3908 T3907 prep of,amounts
R3067 T3909 T3908 pobj IL-10,of
R3068 T3968 T3967 prep to,related
R3069 T3910 T3909 cc and,IL-10
R3070 T3911 T3909 conj IFN-γ,IL-10
R3071 T3969 T3970 amod limited,IL-2
R3072 T3912 T3903 cc and,differentiated
R3073 T3913 T3913 ROOT lost,lost
R3074 T3970 T3968 pobj IL-2,to
R3075 T3971 T3953 punct .,showed
R3076 T3914 T3915 poss their,capacity
R3077 T3972 T3976 amod Naive,cells
R3078 T3973 T3976 compound CD4,cells
R3079 T3915 T3913 dobj capacity,lost
R3080 T3974 T3976 nummod +,cells
R3081 T3975 T3976 compound T,cells
R3082 T3916 T3917 aux to,produce
R3083 T3976 T4004 nsubj cells,resulted
R3084 T3977 T3976 prep from,cells
R3085 T3917 T3915 acl produce,capacity
R3086 T3918 T3917 dobj IL-2,produce
R3087 T3978 T3977 pobj DO11,from
R3088 T3919 T3921 punct (,1B
R3089 T3920 T3921 compound Figure,1B
R3090 T3921 T3918 appos 1B,IL-2
R3091 T3922 T3921 punct ),1B
R3092 T3979 T3978 nummod .10,DO11
R3093 T3923 T3913 punct .,lost
R3094 T3924 T3929 mark Because,reduced
R3095 T3980 T3989 nummod /,animals
R3096 T3925 T3926 det the,presence
R3097 T3926 T3929 nsubj presence,reduced
R3098 T3927 T3926 prep of,presence
R3099 T3928 T3927 pobj IL-12,of
R3100 T3981 T3982 compound recombination-activating,gene
R3101 T3929 T3929 ROOT reduced,reduced
R3102 T3930 T3931 det the,proliferation
R3103 T3931 T3929 dobj proliferation,reduced
R3104 T3982 T3988 npadvmod gene,deficient
R3105 T3932 T3931 prep of,proliferation
R3106 T3933 T3936 nummod CD4,cells
R3107 T3934 T3936 nummod +,cells
R3108 T3983 T3982 nummod 1,gene
R3109 T3935 T3936 compound T,cells
R3110 T3936 T3932 pobj cells,of
R3111 T3984 T3985 punct (,Rag1
R3112 T3937 T3929 prep at,reduced
R3113 T3938 T3939 preconj both,high
R3114 T3939 T3943 amod high,doses
R3115 T3940 T3939 cc and,high
R3116 T3985 T3982 appos Rag1,gene
R3117 T3941 T3939 conj low,high
R3118 T3942 T3943 compound antigen,doses
R3119 T3986 T3985 punct ),Rag1
R3120 T3943 T3937 pobj doses,at
R3121 T3944 T3946 punct (,S1
R3122 T3945 T3946 compound Table,S1
R3123 T3987 T3988 punct -,deficient
R3124 T3946 T3943 appos S1,doses
R3125 T3988 T3989 amod deficient,animals
R3126 T3989 T3976 conj animals,cells
R3127 T3947 T3946 punct ),S1
R3128 T3948 T3929 punct ",",reduced
R3129 T3990 T3989 punct ",",animals
R3130 T3949 T3929 cc and,reduced
R3131 T3950 T3953 advmod only,showed
R3132 T3951 T3952 det the,former
R3133 T3991 T3976 acl cultured,cells
R3134 T3952 T3953 nsubj former,showed
R3135 T3953 T3929 conj showed,reduced
R3136 T3954 T3955 amod IL-10,production
R3137 T3955 T3953 dobj production,showed
R3138 T3956 T3953 punct ",",showed
R3139 T3992 T3991 prep with,cultured
R3140 T3957 T3958 det the,development
R3141 T3958 T3963 nsubj development,is
R3142 T3993 T3994 amod high,doses
R3143 T3959 T3958 prep of,development
R3144 T3960 T3962 amod high,cells
R3145 T3961 T3962 amod IL-10-producing,cells
R3146 T3994 T3992 pobj doses,with
R3147 T3995 T3994 prep of,doses
R3148 T3996 T3995 pobj antigen,of
R3149 T3997 T3991 prep in,cultured
R3150 T3998 T3999 det the,presence
R3151 T4090 T4089 pobj TGF-β,of
R3152 T4091 T4091 ROOT led,led
R3153 T3999 T3997 pobj presence,in
R3154 T4092 T4091 prep to,led
R3155 T4093 T4095 amod increased,production
R3156 T4094 T4095 amod IL-10,production
R3157 T4000 T3999 prep of,presence
R3158 T4095 T4092 pobj production,to
R3159 T4096 T4095 prep by,production
R3160 T4097 T4100 det both,subsets
R3161 T4098 T4099 compound T,cell
R3162 T4001 T4000 pobj IL-12,of
R3163 T4099 T4100 compound cell,subsets
R3164 T4100 T4096 pobj subsets,by
R3165 T4002 T3976 punct ",",cells
R3166 T4101 T4102 punct (,Figure
R3167 T4003 T4004 advmod also,resulted
R3168 T4102 T4100 appos Figure,subsets
R3169 T4103 T4102 nummod S3,Figure
R3170 T4104 T4102 punct ),Figure
R3171 T4004 T4004 ROOT resulted,resulted
R3172 T4105 T4091 punct .,led
R3173 T4106 T4115 advmod Thus,depended
R3174 T4107 T4115 punct ",",depended
R3175 T4005 T4004 prep in,resulted
R3176 T4108 T4109 det the,development
R3177 T4109 T4115 nsubj development,depended
R3178 T4110 T4109 prep of,development
R3179 T4006 T4007 compound IL-10,expression
R3180 T4111 T4113 amod IL-10-producing,cells
R3181 T4112 T4113 amod Th1,cells
R3182 T4113 T4110 pobj cells,of
R3183 T4007 T4005 pobj expression,in
R3184 T4114 T4115 advmod only,depended
R3185 T4115 T4115 ROOT depended,depended
R3186 T4116 T4115 prep on,depended
R3187 T4117 T4118 det the,presence
R3188 T4008 T4004 prep by,resulted
R3189 T4118 T4116 pobj presence,on
R3190 T4119 T4118 prep of,presence
R3191 T4009 T4010 amod Th1,cells
R3192 T4120 T4119 pobj IL-12,of
R3193 T4121 T4122 advmod together,with
R3194 T4122 T4115 prep with,depended
R3195 T4010 T4008 pobj cells,by
R3196 T4123 T4125 amod high,dose
R3197 T4124 T4125 compound antigen,dose
R3198 T4125 T4122 pobj dose,with
R3199 T4011 T4004 punct ",",resulted
R3200 T4126 T4125 cc and,dose
R3201 T4127 T4128 neg not,on
R3202 T4012 T4004 advcl showing,resulted
R3203 T4128 T4115 prep on,depended
R3204 T4129 T4131 amod other,factors
R3205 T4013 T4016 mark that,was
R3206 T4130 T4131 amod soluble,factors
R3207 T4131 T4128 pobj factors,on
R3208 T4132 T4133 amod such,as
R3209 T4133 T4131 prep as,factors
R3210 T4014 T4015 det this,expression
R3211 T4134 T4133 pobj IL-2,as
R3212 T4135 T4134 cc or,IL-2
R3213 T4136 T4134 conj TGF-β,IL-2
R3214 T4015 T4016 nsubj expression,was
R3215 T4137 T4128 cc or,on
R3216 T4138 T4128 conj on,on
R3217 T4139 T4140 det the,presence
R3218 T4016 T4012 ccomp was,showing
R3219 T4140 T4138 pobj presence,on
R3220 T4141 T4140 prep of,presence
R3221 T4017 T4018 neg not,dependent
R3222 T4142 T4145 amod other,types
R3223 T4143 T4145 compound T,types
R3224 T4144 T4145 compound cell,types
R3225 T4145 T4141 pobj types,of
R3226 T4018 T4016 acomp dependent,was
R3227 T4146 T4115 punct .,depended
R3228 T4019 T4018 prep on,dependent
R3229 T4020 T4021 det the,presence
R3230 T4021 T4019 pobj presence,on
R3231 T4022 T4021 prep of,presence
R3232 T4023 T4022 pobj effector,of
R3233 T4024 T4023 cc or,effector
R3234 T4025 T4027 compound memory,cells
R3235 T4026 T4027 compound T,cells
R3236 T4027 T4023 conj cells,effector
R3237 T4028 T4027 cc or,cells
R3238 T4029 T4030 compound Treg,cells
R3239 T4030 T4027 conj cells,cells
R3240 T4031 T4032 punct (,Figure
R3241 T4032 T4021 appos Figure,presence
R3242 T4033 T4032 nummod S2,Figure
R3243 T4034 T4032 punct ),Figure
R3244 T4035 T4004 punct .,resulted
R3245 T4036 T4040 mark Although,suggested
R3246 T4037 T4040 nsubjpass it,suggested
R3247 T4038 T4040 aux has,suggested
R3248 T4039 T4040 auxpass been,suggested
R3249 T4040 T4066 advcl suggested,found
R3250 T4041 T4044 mark that,induce
R3251 T4042 T4044 nsubj TGF-β,induce
R3252 T4043 T4044 aux can,induce
R3253 T4044 T4040 ccomp induce,suggested
R3254 T4045 T4044 dobj IL-10,induce
R3255 T4046 T4044 prep in,induce
R3256 T4047 T4050 nmod CD4,cells
R3257 T4048 T4050 nmod +,cells
R3258 T4049 T4050 compound T,cells
R3259 T4050 T4046 pobj cells,in
R3260 T4051 T4054 punct (,al.
R3261 T4052 T4054 compound Kitani,al.
R3262 T4053 T4054 nmod et,al.
R3263 T4054 T4044 parataxis al.,induce
R3264 T4055 T4054 punct ",",al.
R3265 T4056 T4054 npadvmod 2003,al.
R3266 T4057 T4044 punct ;,induce
R3267 T4058 T4060 compound Schiott,al.
R3268 T4059 T4060 compound et,al.
R3269 T4060 T4040 oprd al.,suggested
R3270 T4061 T4060 punct ",",al.
R3271 T4062 T4060 appos 2000,al.
R3272 T4063 T4060 punct ),al.
R3273 T4064 T4066 punct ",",found
R3274 T4065 T4066 nsubj we,found
R3275 T4066 T4066 ROOT found,found
R3276 T4067 T4075 mark that,was
R3277 T4068 T4075 prep in,was
R3278 T4069 T4068 pcomp developing,in
R3279 T4070 T4073 nmod Th1,cells
R3280 T4071 T4070 cc and,Th1
R3281 T4072 T4070 conj Th2,Th1
R3282 T4073 T4069 dobj cells,developing
R3283 T4074 T4075 nsubj this,was
R3284 T4075 T4066 ccomp was,found
R3285 T4076 T4075 neg not,was
R3286 T4077 T4078 det the,case
R3287 T4078 T4075 attr case,was
R3288 T4079 T4082 punct (,shown
R3289 T4080 T4082 nsubjpass data,shown
R3290 T4081 T4082 neg not,shown
R3291 T4082 T4075 conj shown,was
R3292 T4083 T4082 punct ),shown
R3293 T4084 T4066 punct .,found
R3294 T4085 T4091 prep In,led
R3295 T4086 T4085 pobj fact,In
R3297 T4087 T4091 punct ",",led
R3299 T4088 T4091 nsubj neutralization,led
R3301 T4089 T4088 prep of,neutralization
R4337 T5679 T5680 compound IL-10,Production
R4338 T5680 T5684 nsubj Production,Is
R4339 T5681 T5680 prep by,Production
R4340 T5682 T5683 compound Th1,Cells
R4341 T5683 T5681 pobj Cells,by
R4342 T5684 T5684 ROOT Is,Is
R4343 T5685 T5684 acomp Dependent,Is
R4344 T5686 T5684 prep on,Is
R4345 T5687 T5686 pobj STAT4,on
R4346 T5688 T5684 cc but,Is
R4347 T5689 T5690 neg Not,on
R4348 T5690 T5697 prep on,Signaling
R4349 T5691 T5690 pobj STAT6,on
R4350 T5692 T5691 punct ",",STAT6
R4351 T5693 T5691 conj IFN-γ,STAT6
R4352 T5694 T5693 punct ",",IFN-γ
R4353 T5695 T5693 cc or,IFN-γ
R4354 T5696 T5697 compound IL-4,Signaling
R4355 T5697 T5700 nsubj Signaling,elucidate
R4356 T5698 T5700 aux To,elucidate
R4357 T5699 T5700 advmod further,elucidate
R4358 T5700 T5684 conj elucidate,Is
R4359 T5701 T5702 det the,mechanisms
R4360 T5702 T5700 dobj mechanisms,elucidate
R4361 T5703 T5702 acl required,mechanisms
R4362 T5704 T5703 prep for,required
R4363 T5705 T5706 det the,development
R4364 T5706 T5704 pobj development,for
R4365 T5707 T5706 prep of,development
R4366 T5708 T5709 amod Th1,cells
R4367 T5709 T5707 pobj cells,of
R4368 T5710 T5709 acl producing,cells
R4369 T5711 T5710 dobj IL-10,producing
R4370 T5712 T5714 punct ",",investigated
R4371 T5713 T5714 nsubj we,investigated
R4372 T5714 T5684 conj investigated,Is
R4373 T5715 T5716 det the,role
R4374 T5716 T5714 dobj role,investigated
R4375 T5717 T5716 prep of,role
R4376 T5718 T5717 pobj STAT4,of
R4377 T5719 T5718 punct ",",STAT4
R4378 T5720 T5718 appos one,STAT4
R4379 T5721 T5720 prep of,one
R4380 T5722 T5724 det the,pathways
R4381 T5723 T5724 amod signaling,pathways
R4382 T5724 T5721 pobj pathways,of
R4383 T5725 T5724 acl activated,pathways
R4384 T5726 T5725 agent by,activated
R4385 T5727 T5726 pobj IL-12,by
R4386 T5728 T5731 punct (,al.
R4387 T5729 T5731 compound Murphy,al.
R4388 T5730 T5731 nmod et,al.
R4389 T5731 T5720 appos al.,one
R4390 T5732 T5731 punct ",",al.
R4391 T5733 T5731 dep 2000,al.
R4392 T5734 T5731 punct ),al.
R4393 T5735 T5684 punct .,Is
R4394 T5736 T5742 amod Naive,cells
R4395 T5737 T5742 nmod CD4,cells
R4396 T5738 T5742 nmod +,cells
R4397 T5739 T5742 nmod D011,cells
R4398 T5740 T5742 nummod .10,cells
R4399 T5741 T5742 compound T,cells
R4400 T5742 T5753 nsubj cells,were
R4401 T5743 T5742 acl deficient,cells
R4402 T5744 T5743 prep in,deficient
R4403 T5745 T5744 pobj STAT4,in
R4404 T5746 T5749 punct (,al.
R4405 T5747 T5749 nmod Ouyang,al.
R4406 T5748 T5749 nmod et,al.
R4407 T5749 T5743 appos al.,deficient
R4408 T5750 T5749 punct ",",al.
R4409 T5751 T5749 npadvmod 1998,al.
R4410 T5752 T5742 punct ),cells
R4411 T5753 T5753 ROOT were,were
R4412 T5754 T5753 acomp cultured,were
R4413 T5755 T5754 prep in,cultured
R4414 T5756 T5757 det the,presence
R4415 T5757 T5755 pobj presence,in
R4416 T5758 T5757 prep of,presence
R4417 T5759 T5758 pobj IL-12,of
R4418 T5760 T5759 cc and,IL-12
R4419 T5761 T5759 conj OVA,IL-12
R4420 T5762 T5753 punct .,were
R4421 T5763 T5769 advmod Again,differentiated
R4422 T5764 T5769 punct ",",differentiated
R4423 T5765 T5767 amod IL-10-producing,cells
R4424 T5766 T5767 amod Th1,cells
R4425 T5767 T5769 nsubjpass cells,differentiated
R4426 T5768 T5769 auxpass were,differentiated
R4427 T5769 T5769 ROOT differentiated,differentiated
R4428 T5770 T5769 prep at,differentiated
R4429 T5771 T5774 det the,dose
R4430 T5772 T5773 amod high,antigen
R4431 T5773 T5774 compound antigen,dose
R4432 T5774 T5770 pobj dose,at
R4433 T5775 T5769 prep in,differentiated
R4434 T5776 T5777 det the,presence
R4435 T5777 T5775 pobj presence,in
R4436 T5778 T5777 prep of,presence
R4437 T5779 T5778 pobj IL-12,of
R4438 T5780 T5777 prep in,presence
R4439 T5781 T5784 nmod DO11,cells
R4440 T5782 T5784 nummod .10,cells
R4441 T5783 T5784 compound T,cells
R4442 T5784 T5780 pobj cells,in
R4443 T5785 T5787 punct (,2A
R4444 T5786 T5787 compound Figure,2A
R4445 T5787 T5784 appos 2A,cells
R4446 T5788 T5784 punct ),cells
R4447 T5789 T5769 punct .,differentiated
R4448 T5790 T5807 prep In,diminished
R4449 T5791 T5790 pobj contrast,In
R4450 T5792 T5807 punct ",",diminished
R4451 T5793 T5807 prep in,diminished
R4452 T5794 T5795 det the,absence
R4453 T5795 T5793 pobj absence,in
R4454 T5796 T5795 prep of,absence
R4455 T5797 T5796 pobj STAT4,of
R4456 T5798 T5797 punct ",",STAT4
R4457 T5799 T5800 det the,percentage
R4458 T5800 T5807 nsubjpass percentage,diminished
R4459 T5801 T5800 prep of,percentage
R4460 T5802 T5801 pobj cells,of
R4461 T5803 T5802 acl expressing,cells
R4462 T5804 T5803 dobj IFN-γ,expressing
R4463 T5805 T5807 auxpass was,diminished
R4464 T5806 T5807 advmod dramatically,diminished
R4465 T5807 T5807 ROOT diminished,diminished
R4466 T5808 T5809 mark as,expected
R4467 T5809 T5807 advcl expected,diminished
R4468 T5810 T5809 cc and,expected
R4469 T5811 T5809 conj resulted,expected
R4470 T5812 T5811 prep in,resulted
R4471 T5813 T5814 det an,increase
R4472 T5814 T5812 pobj increase,in
R4473 T5815 T5814 prep in,increase
R4474 T5816 T5817 det the,percentage
R4475 T5817 T5815 pobj percentage,in
R4476 T5818 T5817 prep of,percentage
R4477 T5819 T5818 pobj cells,of
R4478 T5820 T5819 acl expressing,cells
R4479 T5821 T5820 dobj IL-4,expressing
R4480 T5822 T5811 punct ",",resulted
R4481 T5823 T5811 cc but,resulted
R4482 T5824 T5831 neg not,suggesting
R4483 T5825 T5831 dep IL-10,suggesting
R4484 T5826 T5828 punct (,2A
R4485 T5827 T5828 compound Figure,2A
R4486 T5828 T5825 parataxis 2A,IL-10
R4487 T5829 T5828 punct ),2A
R4488 T5830 T5831 punct ",",suggesting
R4489 T5831 T5807 advcl suggesting,diminished
R4490 T5832 T5834 mark that,contributes
R4491 T5833 T5834 nsubj STAT4,contributes
R4492 T5834 T5831 ccomp contributes,suggesting
R4493 T5835 T5834 prep to,contributes
R4494 T5836 T5837 compound IL-10,expression
R4495 T5837 T5835 pobj expression,to
R4496 T5838 T5837 prep by,expression
R4497 T5839 T5840 amod Th1,cells
R4498 T5840 T5838 pobj cells,by
R4499 T5841 T5807 punct .,diminished
R4500 T5842 T5846 mark Because,associated
R4501 T5843 T5844 compound IL-10,expression
R4502 T5844 T5846 nsubjpass expression,associated
R4503 T5845 T5846 auxpass is,associated
R4504 T5846 T5855 advcl associated,investigated
R4505 T5847 T5846 prep with,associated
R4506 T5848 T5852 det an,phenotype
R4507 T5849 T5851 amod IL-4-induced,cell
R4508 T5850 T5851 compound Th2,cell
R4509 T5851 T5852 compound cell,phenotype
R4510 T5852 T5847 pobj phenotype,with
R4511 T5853 T5855 punct ",",investigated
R4512 T5854 T5855 nsubj we,investigated
R4513 T5855 T5855 ROOT investigated,investigated
R4514 T5856 T5864 mark whether,depended
R4515 T5857 T5858 det the,differentiation
R4516 T5858 T5864 nsubj differentiation,depended
R4517 T5859 T5858 prep of,differentiation
R4518 T5860 T5863 det the,cells
R4519 T5861 T5863 amod IL-10-producing,cells
R4520 T5862 T5863 amod Th1,cells
R4521 T5863 T5859 pobj cells,of
R4522 T5864 T5855 ccomp depended,investigated
R4523 T5865 T5864 prep on,depended
R4524 T5866 T5865 pcomp signaling,on
R4525 T5867 T5866 prep through,signaling
R4526 T5868 T5870 det the,receptor
R4527 T5869 T5870 compound IL-4,receptor
R4528 T5870 T5867 pobj receptor,through
R4529 T5871 T5866 prep via,signaling
R4530 T5872 T5873 compound STAT6,activation
R4531 T5873 T5871 pobj activation,via
R4532 T5874 T5883 punct (,al.
R4533 T5875 T5883 nmod Glimcher,al.
R4534 T5876 T5875 cc and,Glimcher
R4535 T5877 T5875 conj Murphy,Glimcher
R4536 T5878 T5877 punct ",",Murphy
R4537 T5879 T5877 npadvmod 2000,Murphy
R4538 T5880 T5883 punct ;,al.
R4539 T5881 T5883 compound Murphy,al.
R4540 T5882 T5883 nmod et,al.
R4541 T5883 T5864 parataxis al.,depended
R4542 T5884 T5883 punct ",",al.
R4543 T5885 T5883 appos 2000,al.
R4544 T5886 T5883 punct ),al.
R4545 T5887 T5855 punct .,investigated
R4546 T5888 T5889 det The,absence
R4547 T5889 T5894 nsubj absence,impair
R4548 T5890 T5889 prep of,absence
R4549 T5891 T5890 pobj STAT6,of
R4550 T5892 T5894 aux did,impair
R4551 T5893 T5894 neg not,impair
R4552 T5894 T5894 ROOT impair,impair
R4553 T5895 T5896 det the,differentiation
R4554 T5896 T5894 dobj differentiation,impair
R4555 T5897 T5896 prep of,differentiation
R4556 T5898 T5900 amod IL-10-producing,cells
R4557 T5899 T5900 amod Th1,cells
R4558 T5900 T5897 pobj cells,of
R4559 T5901 T5896 prep in,differentiation
R4560 T5902 T5903 det the,presence
R4561 T5903 T5901 pobj presence,in
R4562 T5904 T5903 prep of,presence
R4563 T5905 T5904 pobj IL-12,of
R4564 T5906 T5905 cc and,IL-12
R4565 T5907 T5905 conj OVA,IL-12
R4566 T5908 T5910 punct (,2A
R4567 T5909 T5910 compound Figure,2A
R4568 T5910 T5907 appos 2A,OVA
R4569 T5911 T5907 punct ),OVA
R4570 T5912 T5894 punct .,impair
R4571 T5913 T5918 prep In,percentage
R4572 T5914 T5913 pobj fact,In
R4573 T5915 T5918 punct ",",percentage
R4574 T5916 T5918 det a,percentage
R4575 T5917 T5918 amod higher,percentage
R4576 T5918 T5918 ROOT percentage,percentage
R4577 T5919 T5918 prep of,percentage
R4578 T5920 T5921 amod STAT6-deficient,cells
R4579 T5921 T5919 pobj cells,of
R4580 T5922 T5918 prep compared,percentage
R4581 T5923 T5922 prep with,compared
R4582 T5924 T5925 compound WT,cells
R4583 T5925 T5923 pobj cells,with
R4584 T5926 T5925 acl produced,cells
R4585 T5927 T5928 preconj both,IL-10
R4586 T5928 T5926 dobj IL-10,produced
R4587 T5929 T5928 cc and,IL-10
R4588 T5930 T5928 conj IFN-γ,IL-10
R4589 T5931 T5933 punct (,2A
R4590 T5932 T5933 compound Figure,2A
R4591 T5933 T5930 parataxis 2A,IFN-γ
R4592 T5934 T5933 punct ),2A
R4593 T5935 T5928 punct ",",IL-10
R4594 T5936 T5938 nsubj which,be
R4595 T5937 T5938 aux may,be
R4596 T5938 T5928 relcl be,IL-10
R4597 T5939 T5940 det the,result
R4598 T5940 T5938 attr result,be
R4599 T5941 T5940 prep of,result
R4600 T5942 T5943 det the,loss
R4601 T5943 T5941 pobj loss,of
R4602 T5944 T5943 prep of,loss
R4603 T5945 T5947 compound Th2,control
R4604 T5946 T5947 compound cell,control
R4605 T5947 T5944 pobj control,of
R4606 T5948 T5947 prep over,control
R4607 T5949 T5952 det a,response
R4608 T5950 T5952 amod Th1,response
R4609 T5951 T5952 compound cell,response
R4610 T5952 T5948 pobj response,over
R4611 T5953 T5918 punct .,percentage
R4612 T5954 T5955 mark As,expected
R4613 T5955 T5960 advcl expected,abrogated
R4614 T5956 T5960 punct ",",abrogated
R4615 T5957 T5960 nsubj lack,abrogated
R4616 T5958 T5957 prep of,lack
R4617 T5959 T5958 pobj STAT6,of
R4618 T5960 T5960 ROOT abrogated,abrogated
R4619 T5961 T5962 det both,IL-4
R4620 T5962 T5960 dobj IL-4,abrogated
R4621 T5963 T5962 cc and,IL-4
R4622 T5964 T5965 compound IL-10,production
R4623 T5965 T5969 nsubj production,developed
R4624 T5966 T5965 prep by,production
R4625 T5967 T5968 compound T,cells
R4626 T5968 T5966 pobj cells,by
R4627 T5969 T5960 conj developed,abrogated
R4628 T5970 T5969 prep with,developed
R4629 T5971 T5970 pobj IL-4,with
R4630 T5972 T5970 cc or,with
R4631 T5973 T5970 conj with,with
R4632 T5974 T5976 amod low,dose
R4633 T5975 T5976 compound antigen,dose
R4634 T5976 T5973 pobj dose,with
R4635 T5977 T5979 punct (,2B
R4636 T5978 T5979 compound Figures,2B
R4637 T5979 T5976 appos 2B,dose
R4638 T5980 T5979 cc and,2B
R4639 T5981 T5979 conj 2C,2B
R4640 T5982 T5979 punct ),2B
R4641 T5983 T5969 punct .,developed
R4642 T5984 T6000 advmod However,was
R4643 T5985 T6000 punct ",",was
R4644 T5986 T6000 prep in,was
R4645 T5987 T5988 det the,absence
R4646 T5988 T5986 pobj absence,in
R4647 T5989 T5988 prep of,absence
R4648 T5990 T5989 pobj STAT4,of
R4649 T5991 T5986 pcomp signaling,in
R4650 T5992 T5991 punct ",",signaling
R4651 T5993 T5996 nmod IL-10,production
R4652 T5994 T5993 cc and,IL-10
R4653 T5995 T5996 compound IL-4,production
R4654 T5996 T5991 dobj production,signaling
R4655 T5997 T5996 prep by,production
R4656 T5998 T5999 amod Th2,cells
R4657 T5999 T5997 pobj cells,by
R4658 T6000 T6000 ROOT was,was
R4659 T6001 T6003 mark if,increased
R4660 T6002 T6003 nsubj anything,increased
R4661 T6003 T6000 advcl increased,was
R4662 T6004 T6006 punct (,2B
R4663 T6005 T6006 compound Figures,2B
R4664 T6006 T6003 npadvmod 2B,increased
R4665 T6007 T6006 cc and,2B
R4666 T6008 T6006 conj 2C,2B
R4667 T6009 T6006 punct ),2B
R4668 T6010 T6000 punct .,was
R4669 T6011 T6028 advmod Thus,depended
R4670 T6012 T6028 punct ",",depended
R4671 T6013 T6028 prep in,depended
R4672 T6014 T6013 pobj contrast,in
R4673 T6015 T6014 prep to,contrast
R4674 T6016 T6018 nsubjpass what,observed
R4675 T6017 T6018 auxpass was,observed
R4676 T6018 T6015 pcomp observed,to
R4677 T6019 T6018 prep under,observed
R4678 T6020 T6021 amod Th1,conditions
R4679 T6021 T6019 pobj conditions,under
R4680 T6022 T6018 punct ",",observed
R4681 T6023 T6024 amod IL-10,expression
R4682 T6024 T6015 pobj expression,to
R4683 T6025 T6024 prep by,expression
R4684 T6026 T6027 amod Th2,cells
R4685 T6027 T6025 pobj cells,by
R4686 T6028 T6028 ROOT depended,depended
R4687 T6029 T6028 prep on,depended
R4688 T6030 T6029 pobj STAT6,on
R4689 T6031 T6028 punct ",",depended
R4690 T6032 T6028 cc but,depended
R4691 T6033 T6034 neg not,on
R4692 T6034 T6037 prep on,signaling
R4693 T6035 T6034 pobj STAT4,on
R4694 T6036 T6037 punct ",",signaling
R4695 T6037 T6028 conj signaling,depended
R4696 T6038 T6040 punct (,2B
R4697 T6039 T6040 compound Figures,2B
R4698 T6040 T6037 dobj 2B,signaling
R4699 T6041 T6040 cc and,2B
R4700 T6042 T6040 conj 2C,2B
R4701 T6043 T6040 punct ),2B
R4702 T6044 T6028 punct .,depended
R4703 T6045 T6046 aux To,investigate
R4704 T6046 T6078 advcl investigate,differentiated
R4705 T6047 T6058 mark whether,be
R4706 T6048 T6049 det the,inability
R4707 T6049 T6058 nsubj inability,be
R4708 T6050 T6049 prep of,inability
R4709 T6051 T6052 compound STAT4-deficient,T
R4710 T6052 T6053 compound T,cells
R4711 T6053 T6050 pobj cells,of
R4712 T6054 T6055 aux to,produce
R4713 T6055 T6049 acl produce,inability
R4714 T6056 T6055 dobj IL-10,produce
R4715 T6057 T6058 aux might,be
R4716 T6058 T6046 ccomp be,investigate
R4717 T6059 T6058 acomp due,be
R4718 T6060 T6059 pcomp to,due
R4719 T6061 T6062 det the,absence
R4720 T6062 T6060 pobj absence,to
R4721 T6063 T6062 prep of,absence
R4722 T6064 T6063 pobj IFN-γ,of
R4723 T6065 T6058 punct ",",be
R4724 T6066 T6067 mark as,suggested
R4725 T6067 T6058 advcl suggested,be
R4726 T6068 T6067 advmod before,suggested
R4727 T6069 T6072 punct (,al.
R4728 T6070 T6072 compound Shaw,al.
R4729 T6071 T6072 nmod et,al.
R4730 T6072 T6046 prep al.,investigate
R4731 T6073 T6072 punct ",",al.
R4732 T6074 T6072 npadvmod 2006,al.
R4733 T6075 T6072 punct ),al.
R4734 T6076 T6078 punct ",",differentiated
R4735 T6077 T6078 nsubj we,differentiated
R4736 T6078 T6078 ROOT differentiated,differentiated
R4737 T6079 T6078 dobj DO11,differentiated
R4738 T6080 T6089 nummod .10,cells
R4739 T6081 T6080 cc or,.10
R4740 T6082 T6089 nummod DO11,cells
R4741 T6083 T6084 nummod .10,IFN-γ-deficient
R4742 T6084 T6085 npadvmod IFN-γ-deficient,naive
R4743 T6085 T6089 amod naive,cells
R4744 T6086 T6089 compound CD4,cells
R4745 T6087 T6089 nummod +,cells
R4746 T6088 T6089 compound T,cells
R4747 T6089 T6078 conj cells,differentiated
R4748 T6090 T6089 prep in,cells
R4749 T6091 T6092 det the,presence
R4750 T6092 T6090 pobj presence,in
R4751 T6093 T6092 prep of,presence
R4752 T6094 T6093 pobj IL-12,of
R4753 T6095 T6089 cc and,cells
R4754 T6096 T6097 amod increasing,doses
R4755 T6097 T6089 conj doses,cells
R4756 T6098 T6097 prep of,doses
R4757 T6099 T6098 pobj OVA,of
R4758 T6100 T6078 punct .,differentiated
R4759 T6101 T6102 det The,secretion
R4760 T6102 T6116 nsubjpass secretion,affected
R4761 T6103 T6102 prep of,secretion
R4762 T6104 T6103 pobj IL-10,of
R4763 T6105 T6106 mark as,induced
R4764 T6106 T6102 advcl induced,secretion
R4765 T6107 T6106 agent by,induced
R4766 T6108 T6110 amod high,dose
R4767 T6109 T6110 compound antigen,dose
R4768 T6110 T6107 pobj dose,by
R4769 T6111 T6102 punct ",",secretion
R4770 T6112 T6102 cc and,secretion
R4771 T6113 T6102 conj IL-12,secretion
R4772 T6114 T6116 auxpass was,affected
R4773 T6115 T6116 neg not,affected
R4774 T6116 T6116 ROOT affected,affected
R4775 T6117 T6116 agent by,affected
R4776 T6118 T6119 det an,absence
R4777 T6119 T6117 pobj absence,by
R4778 T6120 T6119 prep of,absence
R4779 T6121 T6120 pobj IFN-γ,of
R4780 T6122 T6124 punct (,2D
R4781 T6123 T6124 compound Figure,2D
R4782 T6124 T6121 appos 2D,IFN-γ
R4783 T6125 T6124 punct ),2D
R4784 T6126 T6116 punct ",",affected
R4785 T6127 T6116 advcl showing,affected
R4786 T6128 T6136 mark that,is
R4787 T6129 T6130 det the,expression
R4788 T6130 T6136 nsubj expression,is
R4789 T6131 T6130 prep of,expression
R4790 T6132 T6131 pobj IL-10,of
R4791 T6133 T6130 prep by,expression
R4792 T6134 T6135 amod Th1,cells
R4793 T6135 T6133 pobj cells,by
R4794 T6136 T6127 ccomp is,showing
R4795 T6137 T6136 acomp independent,is
R4796 T6138 T6137 prep of,independent
R4797 T6139 T6138 pobj IFN-γ,of
R4798 T6140 T6116 punct .,affected
R4799 T6141 T6148 prep In,observed
R4800 T6142 T6143 det the,absence
R4801 T6143 T6141 pobj absence,In
R4802 T6144 T6143 prep of,absence
R4803 T6145 T6144 pobj IFN-γ,of
R4804 T6146 T6148 punct ",",observed
R4805 T6147 T6148 nsubj we,observed
R4806 T6148 T6148 ROOT observed,observed
R4807 T6149 T6150 det an,increase
R4808 T6150 T6148 dobj increase,observed
R4809 T6151 T6150 prep in,increase
R4810 T6152 T6154 det the,IL-4
R4811 T6204 T6205 det the,absence
R4812 T6153 T6154 amod secreted,IL-4
R4813 T6154 T6151 pobj IL-4,in
R4814 T6205 T6203 pobj absence,in
R4815 T6206 T6205 prep of,absence
R4816 T6155 T6156 mark as,expected
R4817 T6207 T6206 pobj STAT6,of
R4818 T6208 T6210 punct (,2A
R4819 T6209 T6210 compound Figure,2A
R4820 T6156 T6158 amod expected,data
R4821 T6210 T6207 appos 2A,STAT6
R4822 T6211 T6210 punct ),2A
R4823 T6157 T6158 punct (,data
R4824 T6212 T6207 punct ",",STAT6
R4825 T6213 T6214 amod IL-4,deficiency
R4826 T6214 T6215 nsubj deficiency,had
R4827 T6158 T6150 conj data,increase
R4828 T6215 T6215 ROOT had,had
R4829 T6216 T6217 det no,effect
R4830 T6159 T6160 neg not,shown
R4831 T6217 T6215 dobj effect,had
R4832 T6218 T6217 prep on,effect
R4833 T6160 T6158 acl shown,data
R4834 T6219 T6220 det the,development
R4835 T6220 T6218 pobj development,on
R4836 T6221 T6220 prep of,development
R4837 T6161 T6158 punct ),data
R4838 T6222 T6223 amod Th1,cells
R4839 T6223 T6221 pobj cells,of
R4840 T6162 T6148 punct .,observed
R4841 T6163 T6165 nsubj We,tested
R4842 T6224 T6223 acl producing,cells
R4843 T6164 T6165 advmod also,tested
R4844 T6225 T6224 dobj IL-10,producing
R4845 T6226 T6228 punct (,2E
R4846 T6227 T6228 compound Figure,2E
R4847 T6165 T6165 ROOT tested,tested
R4848 T6228 T6225 parataxis 2E,IL-10
R4849 T6229 T6228 punct ),2E
R4850 T6230 T6215 punct ",",had
R4851 T6231 T6215 cc but,had
R4852 T6166 T6165 prep for,tested
R4853 T6232 T6215 conj compromised,had
R4854 T6233 T6234 det the,development
R4855 T6234 T6232 dobj development,compromised
R4856 T6235 T6234 prep of,development
R4857 T6167 T6169 det any,role
R4858 T6236 T6237 amod Th2,cells
R4859 T6237 T6235 pobj cells,of
R4860 T6168 T6169 amod potential,role
R4861 T6238 T6237 acl producing,cells
R4862 T6239 T6238 dobj IL-10,producing
R4863 T6240 T6242 punct (,2F
R4864 T6169 T6166 pobj role,for
R4865 T6241 T6242 compound Figure,2F
R4866 T6242 T6239 appos 2F,IL-10
R4867 T6170 T6169 prep of,role
R4868 T6243 T6242 punct ),2F
R4869 T6244 T6215 punct .,had
R4870 T6245 T6249 advmod Thus,suggested
R4871 T6171 T6170 pobj IL-4,of
R4872 T6246 T6249 punct ",",suggested
R4873 T6247 T6248 poss our,data
R4874 T6248 T6249 nsubj data,suggested
R4875 T6172 T6169 prep in,role
R4876 T6249 T6249 ROOT suggested,suggested
R4877 T6250 T6258 mark that,was
R4878 T6173 T6174 det the,development
R4879 T6251 T6252 compound IL-10,production
R4880 T6252 T6258 nsubj production,was
R4881 T6253 T6252 prep by,production
R4882 T6174 T6172 pobj development,in
R4883 T6254 T6257 nummod Th1,cells
R4884 T6255 T6254 cc or,Th1
R4885 T6256 T6257 nummod Th2,cells
R4886 T6257 T6253 pobj cells,by
R4887 T6175 T6174 prep of,development
R4888 T6258 T6249 ccomp was,suggested
R4889 T6259 T6258 acomp dependent,was
R4890 T6260 T6259 prep on,dependent
R4891 T6176 T6177 amod Th1,cells
R4892 T6261 T6264 det the,pathways
R4893 T6262 T6264 amod specific,pathways
R4894 T6177 T6175 pobj cells,of
R4895 T6263 T6264 amod signaling,pathways
R4896 T6264 T6260 pobj pathways,on
R4897 T6265 T6264 acl required,pathways
R4898 T6178 T6177 acl producing,cells
R4899 T6266 T6265 prep for,required
R4900 T6267 T6268 poss their,differentiation
R4901 T6268 T6266 pobj differentiation,for
R4902 T6269 T6258 punct ",",was
R4903 T6270 T6258 prep given,was
R4904 T6179 T6178 dobj IL-10,producing
R4905 T6271 T6274 mark that,required
R4906 T6272 T6274 nsubjpass STAT4,required
R4907 T6273 T6274 auxpass is,required
R4908 T6274 T6270 pcomp required,given
R4909 T6275 T6274 prep for,required
R4910 T6180 T6178 prep by,producing
R4911 T6276 T6277 det the,induction
R4912 T6277 T6275 pobj induction,for
R4913 T6278 T6277 prep of,induction
R4914 T6181 T6180 pcomp culturing,by
R4915 T6279 T6280 compound IL-10,production
R4916 T6280 T6278 pobj production,of
R4917 T6281 T6277 prep by,induction
R4918 T6182 T6181 dobj DO11,culturing
R4919 T6282 T6283 amod Th1,cells
R4920 T6283 T6281 pobj cells,by
R4921 T6284 T6283 cc and,cells
R4922 T6183 T6182 nummod .10,DO11
R4923 T6285 T6283 conj STAT6,cells
R4924 T6286 T6285 prep for,STAT6
R4925 T6287 T6288 compound Th2,cells
R4926 T6184 T6183 cc or,.10
R4927 T6288 T6286 pobj cells,for
R4928 T6289 T6249 punct .,suggested
R4929 T6185 T6192 nummod DO11,cells
R4930 T6186 T6187 nummod .10,IL-4-deficient
R4931 T6187 T6188 npadvmod IL-4-deficient,naive
R4932 T6188 T6192 amod naive,cells
R4933 T6189 T6192 compound CD4,cells
R4934 T6190 T6192 nummod +,cells
R4935 T6191 T6192 compound T,cells
R4936 T6192 T6182 appos cells,DO11
R4937 T6193 T6192 prep with,cells
R4938 T6194 T6193 pobj IL-12,with
R4939 T6195 T6194 cc and,IL-12
R4940 T6196 T6194 conj increasing,IL-12
R4941 T6197 T6196 dobj doses,increasing
R4942 T6198 T6197 prep of,doses
R4943 T6199 T6198 pobj antigen,of
R4944 T6200 T6165 punct .,tested
R4945 T6201 T6202 mark As,observed
R4946 T6202 T6215 advcl observed,had
R4947 T6203 T6202 prep in,observed
R5565 T7295 T7297 compound High,Doses
R5566 T7296 T7297 compound Antigen,Doses
R5567 T7297 T7301 nsubjpass Doses,Required
R5568 T7298 T7297 cc and,Doses
R5569 T7299 T7297 conj STAT4,Doses
R5570 T7300 T7301 auxpass Are,Required
R5571 T7301 T7325 ccomp Required,transferred
R5572 T7302 T7301 prep for,Required
R5573 T7303 T7306 det the,Generation
R5574 T7304 T7306 compound In,Generation
R5575 T7305 T7306 compound Vivo,Generation
R5576 T7306 T7302 pobj Generation,for
R5577 T7307 T7306 prep of,Generation
R5578 T7308 T7310 compound IL-10-Producing,Cells
R5579 T7309 T7310 compound Th1,Cells
R5580 T7310 T7307 pobj Cells,of
R5581 T7311 T7312 aux To,address
R5582 T7312 T7301 advcl address,Required
R5583 T7313 T7314 det the,mechanisms
R5584 T7314 T7312 dobj mechanisms,address
R5585 T7315 T7314 acl regulating,mechanisms
R5586 T7316 T7317 amod IL-10,production
R5587 T7317 T7315 dobj production,regulating
R5588 T7318 T7317 prep by,production
R5589 T7319 T7320 amod Th1,cells
R5590 T7320 T7318 pobj cells,by
R5591 T7321 T7317 prep in,production
R5592 T7322 T7321 pobj vivo,in
R5593 T7323 T7325 punct ",",transferred
R5594 T7324 T7325 nsubj we,transferred
R5595 T7325 T7325 ROOT transferred,transferred
R5596 T7326 T7325 dobj DO11,transferred
R5597 T7327 T7328 nummod .10,cells
R5598 T7328 T7325 dobj cells,transferred
R5599 T7329 T7325 prep into,transferred
R5600 T7330 T7331 compound BALB/c,recipient
R5601 T7331 T7332 compound recipient,mice
R5602 T7332 T7329 pobj mice,into
R5603 T7333 T7325 cc and,transferred
R5604 T7334 T7325 conj immunized,transferred
R5605 T7335 T7336 det the,recipients
R5606 T7336 T7334 dobj recipients,immunized
R5607 T7337 T7336 prep with,recipients
R5608 T7338 T7339 advmod very,high
R5609 T7339 T7340 amod high,doses
R5610 T7340 T7337 pobj doses,with
R5611 T7341 T7340 prep of,doses
R5612 T7342 T7341 pobj OVA-protein,of
R5613 T7343 T7337 conj with,with
R5614 T7344 T7343 cc or,with
R5615 T7345 T7343 conj without,with
R5616 T7346 T7347 amod added,lipopolysacharide
R5617 T7347 T7345 pobj lipopolysacharide,without
R5618 T7348 T7349 punct (,LPS
R5619 T7349 T7347 appos LPS,lipopolysacharide
R5620 T7350 T7347 punct ),lipopolysacharide
R5621 T7351 T7325 punct .,transferred
R5622 T7352 T7353 compound T,cells
R5623 T7353 T7355 nsubjpass cells,recovered
R5624 T7354 T7355 auxpass were,recovered
R5625 T7355 T7355 ROOT recovered,recovered
R5626 T7356 T7355 prep from,recovered
R5627 T7357 T7360 det the,nodes
R5628 T7358 T7360 amod inguinal,nodes
R5629 T7359 T7360 compound lymph,nodes
R5630 T7360 T7356 pobj nodes,from
R5631 T7361 T7362 nummod 3,days
R5632 T7362 T7363 npadvmod days,after
R5633 T7363 T7355 prep after,recovered
R5634 T7364 T7363 pcomp priming,after
R5635 T7365 T7364 cc and,priming
R5636 T7366 T7355 conj restimulated,recovered
R5637 T7367 T7366 prep in,restimulated
R5638 T7368 T7367 pobj vitro,in
R5639 T7369 T7368 prep with,vitro
R5640 T7370 T7371 compound OVA,peptide
R5641 T7371 T7369 pobj peptide,with
R5642 T7372 T7366 prep for,restimulated
R5643 T7373 T7374 nummod 48,hr
R5644 T7374 T7372 pobj hr,for
R5645 T7375 T7355 punct .,recovered
R5646 T7376 T7380 nsubj This,induced
R5647 T7377 T7376 prep in,This
R5648 T7378 T7379 compound vivo,immunization
R5650 T7380 T7380 ROOT induced,induced
R5651 T7381 T7380 dobj IL-10,induced
R5652 T7382 T7381 cc and,IL-10
R5653 T7383 T7384 compound IFN-γ,production
R5654 T7384 T7381 conj production,IL-10
R5655 T7385 T7384 punct ",",production
R5656 T7386 T7384 cc and,production
R5657 T7387 T7388 det the,amount
R5658 T7388 T7393 nsubjpass amount,enhanced
R5659 T7389 T7388 prep of,amount
R5660 T7390 T7391 amod IL-10,production
R5661 T7391 T7389 pobj production,of
R5662 T7392 T7393 auxpass was,enhanced
R5663 T7393 T7380 conj enhanced,induced
R5664 T7394 T7393 agent by,enhanced
R5665 T7395 T7394 pobj addition,by
R5666 T7396 T7395 prep of,addition
R5667 T7397 T7396 pobj LPS,of
R5668 T7398 T7393 prep in,enhanced
R5669 T7399 T7400 det the,immunization
R5670 T7400 T7398 pobj immunization,in
R5671 T7401 T7403 punct (,3A
R5672 T7402 T7403 compound Figure,3A
R5673 T7403 T7400 appos 3A,immunization
R5674 T7404 T7393 punct ),enhanced
R5675 T7405 T7380 cc and,induced
R5676 T7406 T7420 prep with,shown
R5677 T7407 T7408 amod higher,doses
R5678 T7408 T7406 pobj doses,with
R5679 T7409 T7408 prep of,doses
R5680 T7410 T7409 pobj OVA,of
R5681 T7411 T7410 punct (,OVA
R5682 T7412 T7413 nummod 3,μM
R5683 T7413 T7410 appos μM,OVA
R5684 T7414 T7408 cc versus,doses
R5685 T7415 T7416 nummod 1,μM
R5686 T7416 T7408 conj μM,doses
R5687 T7417 T7416 punct ",",μM
R5688 T7418 T7420 nmod data,shown
R5689 T7419 T7420 neg not,shown
R5690 T7420 T7380 conj shown,induced
R5691 T7421 T7420 punct ),shown
R5692 T7422 T7380 punct .,induced
R5693 T7423 T7424 aux To,test
R5694 T7424 T7443 advcl test,transferred
R5695 T7425 T7426 det the,role
R5696 T7426 T7424 dobj role,test
R5697 T7427 T7426 prep of,role
R5698 T7428 T7427 pobj STAT4,of
R5699 T7429 T7428 cc and,STAT4
R5700 T7430 T7428 conj STAT6,STAT4
R5701 T7431 T7426 acl signaling,role
R5702 T7432 T7431 prep in,signaling
R5703 T7433 T7436 det the,development
R5704 T7434 T7436 nmod in,development
R5705 T7435 T7436 compound vivo,development
R5706 T7436 T7432 pobj development,in
R5707 T7437 T7436 prep of,development
R5708 T7438 T7440 amod IL-10-producing,cells
R5709 T7439 T7440 amod Th1,cells
R5710 T7440 T7437 pobj cells,of
R5711 T7441 T7443 punct ",",transferred
R5712 T7442 T7443 nsubj we,transferred
R5713 T7443 T7443 ROOT transferred,transferred
R5714 T7444 T7443 dobj STAT4,transferred
R5715 T7445 T7444 punct -,STAT4
R5716 T7446 T7444 cc or,STAT4
R5717 T7447 T7444 conj STAT6-deficient,STAT4
R5718 T7448 T7447 cc or,STAT6-deficient
R5719 T7449 T7447 conj WT,STAT6-deficient
R5720 T7450 T7447 conj DO11,STAT6-deficient
R5721 T7451 T7452 nummod .10,cells
R5722 T7452 T7443 dobj cells,transferred
R5723 T7453 T7443 prep into,transferred
R5724 T7454 T7456 compound recipient,mice
R5725 T7455 T7456 compound BALB/c,mice
R5726 T7456 T7453 pobj mice,into
R5727 T7457 T7443 cc and,transferred
R5728 T7458 T7443 conj immunized,transferred
R5729 T7459 T7458 prep with,immunized
R5730 T7460 T7459 pobj OVA-protein,with
R5731 T7461 T7460 cc plus,OVA-protein
R5732 T7462 T7460 conj LPS,OVA-protein
R5733 T7463 T7460 prep as,OVA-protein
R5734 T7464 T7463 pcomp before,as
R5735 T7465 T7443 punct .,transferred
R5736 T7466 T7476 prep In,reduced
R5737 T7467 T7468 compound vivo,expression
R5738 T7468 T7476 nsubjpass expression,reduced
R5739 T7469 T7468 prep of,expression
R5740 T7470 T7471 preconj both,IL-10
R5741 T7471 T7469 pobj IL-10,of
R5743 T7473 T7471 conj IFN-γ,IL-10
R5744 T7474 T7476 auxpass was,reduced
R5745 T7475 T7476 advmod markedly,reduced
R5746 T7476 T7476 ROOT reduced,reduced
R5747 T7477 T7476 cc but,reduced
R5748 T7478 T7480 neg not,abrogated
R5749 T7479 T7480 advmod completely,abrogated
R5750 T7480 T7476 conj abrogated,reduced
R5751 T7481 T7480 prep in,abrogated
R5752 T7482 T7483 det the,absence
R5753 T7483 T7481 pobj absence,in
R5754 T7484 T7483 prep of,absence
R5755 T7485 T7484 pobj STAT4,of
R5756 T7486 T7480 advcl signaling,abrogated
R5757 T7487 T7489 punct (,3B
R5758 T7488 T7489 compound Figures,3B
R5759 T7489 T7486 dobj 3B,signaling
R5760 T7490 T7489 cc and,3B
R5761 T7491 T7489 conj 3C,3B
R5762 T7492 T7489 punct ),3B
R5763 T7493 T7486 punct ",",signaling
R5764 T7494 T7486 conj suggesting,signaling
R5765 T7495 T7496 det the,existence
R5766 T7496 T7494 dobj existence,suggesting
R5767 T7497 T7496 prep of,existence
R5768 T7498 T7499 amod compensatory,mechanisms
R5769 T7499 T7497 pobj mechanisms,of
R5770 T7500 T7502 nsubjpass that,absent
R5771 T7501 T7502 auxpass were,absent
R5772 T7502 T7499 relcl absent,mechanisms
R5773 T7503 T7502 prep in,absent
R5774 T7504 T7507 det the,system
R5775 T7505 T7507 nmod in,system
R5776 T7506 T7507 amod vitro,system
R5777 T7507 T7503 pobj system,in
R5778 T7508 T7476 punct .,reduced
R5779 T7509 T7509 ROOT Signaling,Signaling
R5780 T7510 T7509 prep through,Signaling
R5781 T7511 T7510 pobj STAT6,through
R5782 T7512 T7509 aux had,Signaling
R5783 T7513 T7514 det no,effect
R5784 T7514 T7512 dobj effect,had
R5785 T7515 T7514 prep on,effect
R5786 T7516 T7517 compound IL-10,production
R5787 T7517 T7515 pobj production,on
R5788 T7518 T7517 prep by,production
R5789 T7519 T7520 amod Th1,cells
R5790 T7520 T7518 pobj cells,by
R5791 T7521 T7522 mark as,shown
R5792 T7522 T7509 advcl shown,Signaling
R5793 T7523 T7522 agent by,shown
R5794 T7524 T7526 amod intracellular,staining
R5795 T7525 T7526 compound cytokine,staining
R5796 T7526 T7523 pobj staining,by
R5797 T7527 T7528 punct (,ICS
R5798 T7528 T7526 parataxis ICS,staining
R5799 T7529 T7528 punct ),ICS
R5800 T7530 T7523 cc and,by
R5801 T7531 T7523 conj by,by
R5802 T7532 T7531 pobj immunoassay,by
R5803 T7533 T7532 prep in,immunoassay
R5804 T7534 T7536 amod STAT6-deficient,cells
R5805 T7535 T7536 compound T,cells
R5806 T7536 T7533 pobj cells,in
R5807 T7537 T7536 punct (,cells
R5808 T7538 T7539 compound Figures,3B
R5809 T7539 T7536 appos 3B,cells
R5810 T7540 T7539 cc and,3B
R5811 T7541 T7539 conj 3C,3B
R5812 T7542 T7536 punct ),cells
R5813 T7543 T7509 punct .,Signaling
R6396 T8364 T8365 compound IL-10,Production
R6397 T8365 T8367 nsubjpass Production,Maintained
R6398 T8366 T8367 auxpass Is,Maintained
R6399 T8367 T8367 ROOT Maintained,Maintained
R6400 T8368 T8367 agent by,Maintained
R6401 T8369 T8372 compound High,Strength
R6402 T8370 T8372 compound TCR,Strength
R6403 T8371 T8372 compound Signal,Strength
R6404 T8372 T8368 pobj Strength,by
R6405 T8373 T8372 cc and,Strength
R6406 T8374 T8372 conj IL-12,Strength
R6407 T8375 T8377 nsubj We,investigated
R6408 T8376 T8377 advmod next,investigated
R6409 T8377 T8367 ccomp investigated,Maintained
R6410 T8378 T8383 mark whether,is
R6411 T8379 T8382 amod repeated,activation
R6412 T8380 T8382 amod strong,activation
R6413 T8381 T8382 compound TCR,activation
R6414 T8382 T8383 nsubj activation,is
R6415 T8383 T8377 ccomp is,investigated
R6416 T8384 T8386 det a,signal
R6417 T8385 T8386 amod compensatory,signal
R6418 T8386 T8383 attr signal,is
R6419 T8387 T8386 prep for,signal
R6420 T8388 T8390 nsubj IL-12-induced,signaling
R6421 T8389 T8390 nummod STAT4,signaling
R6422 T8390 T8387 pcomp signaling,for
R6423 T8391 T8390 prep in,signaling
R6424 T8392 T8393 det the,induction
R6425 T8393 T8391 pobj induction,in
R6426 T8394 T8393 prep of,induction
R6427 T8395 T8394 pobj IL-10,of
R6428 T8396 T8393 prep in,induction
R6429 T8397 T8398 compound Th1,cells
R6430 T8398 T8396 pobj cells,in
R6431 T8399 T8367 punct .,Maintained
R6432 T8400 T8408 prep For,differentiated
R6433 T8401 T8400 pobj this,For
R6434 T8402 T8408 punct ",",differentiated
R6435 T8403 T8406 compound CD4,cells
R6436 T8404 T8406 compound +,cells
R6437 T8405 T8406 compound T,cells
R6438 T8406 T8408 nsubjpass cells,differentiated
R6439 T8407 T8408 auxpass were,differentiated
R6440 T8408 T8408 ROOT differentiated,differentiated
R6441 T8409 T8408 prep for,differentiated
R6442 T8410 T8412 nummod 2,weeks
R6443 T8411 T8412 amod consecutive,weeks
R6444 T8412 T8409 pobj weeks,for
R6445 T8413 T8408 prep with,differentiated
R6446 T8414 T8416 amod high,doses
R6447 T8415 T8416 compound antigen,doses
R6448 T8416 T8413 pobj doses,with
R6449 T8417 T8416 prep in,doses
R6450 T8418 T8419 det the,presence
R6451 T8419 T8417 pobj presence,in
R6452 T8420 T8419 cc or,presence
R6453 T8421 T8419 conj absence,presence
R6454 T8422 T8421 prep of,absence
R6455 T8423 T8422 pobj IL-12,of
R6456 T8424 T8408 prep throughout,differentiated
R6457 T8425 T8427 punct (,4A
R6458 T8426 T8427 compound Figures,4A
R6459 T8427 T8424 pobj 4A,throughout
R6460 T8428 T8408 advcl 4D,differentiated
R6461 T8429 T8428 punct ),4D
R6462 T8430 T8408 punct .,differentiated
R6463 T8431 T8433 compound High,dose
R6464 T8432 T8433 compound antigen,dose
R6465 T8433 T8436 nsubj dose,cooperated
R6466 T8434 T8433 cc and,dose
R6467 T8435 T8433 conj IL-12,dose
R6468 T8436 T8436 ROOT cooperated,cooperated
R6469 T8437 T8438 aux to,induce
R6470 T8438 T8436 xcomp induce,cooperated
R6471 T8439 T8441 amod maximal,production
R6472 T8440 T8441 compound IL-10,production
R6473 T8441 T8438 dobj production,induce
R6474 T8442 T8444 punct (,4A
R6475 T8443 T8444 compound Figures,4A
R6476 T8444 T8438 dep 4A,induce
R6477 T8445 T8444 cc and,4A
R6478 T8446 T8444 conj 4B,4A
R6479 T8447 T8446 punct ),4B
R6480 T8448 T8444 punct ",",4A
R6481 T8449 T8444 prep given,4A
R6482 T8450 T8453 mark that,resulted
R6483 T8451 T8452 det this,combination
R6484 T8452 T8453 nsubj combination,resulted
R6485 T8453 T8449 ccomp resulted,given
R6486 T8454 T8453 prep in,resulted
R6487 T8455 T8457 det the,numbers
R6488 T8456 T8457 amod highest,numbers
R6489 T8457 T8454 pobj numbers,in
R6490 T8458 T8457 prep of,numbers
R6491 T8459 T8461 amod IL-10-producing,cells
R6492 T8460 T8461 amod Th1,cells
R6493 T8461 T8458 pobj cells,of
R6494 T8462 T8436 punct .,cooperated
R6495 T8463 T8467 amod Repeated,stimulation
R6496 T8464 T8465 amod high,antigen
R6497 T8465 T8466 compound antigen,dose
R6498 T8466 T8467 compound dose,stimulation
R6499 T8467 T8475 nsubj stimulation,resulted
R6500 T8468 T8467 prep in,stimulation
R6501 T8469 T8470 det the,absence
R6502 T8470 T8468 pobj absence,in
R6503 T8471 T8470 prep of,absence
R6504 T8472 T8473 advmod exogenously,added
R6505 T8473 T8474 amod added,IL-12
R6506 T8474 T8471 pobj IL-12,of
R6507 T8475 T8475 ROOT resulted,resulted
R6508 T8476 T8475 prep in,resulted
R6509 T8477 T8478 det the,production
R6510 T8478 T8476 pobj production,in
R6511 T8479 T8478 prep of,production
R6512 T8480 T8479 pobj IL-10,of
R6513 T8481 T8475 prep by,resulted
R6514 T8482 T8483 amod Th1,cells
R6515 T8483 T8481 pobj cells,by
R6516 T8484 T8475 punct ",",resulted
R6517 T8485 T8475 advcl suggesting,resulted
R6518 T8486 T8492 mark that,overcome
R6519 T8487 T8490 amod repeated,triggering
R6520 T8488 T8490 amod strong,triggering
R6521 T8489 T8490 compound TCR,triggering
R6522 T8490 T8492 nsubj triggering,overcome
R6523 T8491 T8492 aux may,overcome
R6524 T8492 T8485 ccomp overcome,suggesting
R6525 T8493 T8494 det the,need
R6526 T8494 T8492 dobj need,overcome
R6527 T8495 T8494 prep for,need
R6528 T8496 T8495 pobj IL-12,for
R6529 T8497 T8496 prep for,IL-12
R6530 T8498 T8499 compound IL-10,induction
R6531 T8499 T8497 pobj induction,for
R6532 T8500 T8502 punct (,4C
R6533 T8501 T8502 compound Figures,4C
R6534 T8502 T8499 dobj 4C,induction
R6535 T8503 T8502 cc and,4C
R6536 T8504 T8502 conj 4D,4C
R6537 T8505 T8502 punct ),4C
R6538 T8506 T8475 punct .,resulted
R6539 T8507 T8515 advmod However,abrogated
R6540 T8508 T8515 punct ",",abrogated
R6541 T8509 T8510 amod IL-10,induction
R6542 T8510 T8515 nsubjpass induction,abrogated
R6543 T8511 T8510 prep under,induction
R6544 T8512 T8513 det these,conditions
R6545 T8513 T8511 pobj conditions,under
R6546 T8514 T8515 auxpass was,abrogated
R6547 T8515 T8515 ROOT abrogated,abrogated
R6548 T8516 T8520 advmod when,used
R6549 T8517 T8518 amod IL-12p40-deficient,DCs
R6550 T8518 T8520 nsubjpass DCs,used
R6551 T8519 T8520 auxpass were,used
R6552 T8520 T8515 advcl used,abrogated
R6553 T8521 T8520 prep as,used
R6554 T8522 T8521 pobj APCs,as
R6555 T8523 T8524 punct (,Figure
R6556 T8524 T8522 appos Figure,APCs
R6557 T8525 T8524 nummod 4E,Figure
R6558 T8526 T8524 punct ),Figure
R6559 T8527 T8515 punct .,abrogated
R6560 T8528 T8531 advmod Thus,is
R6561 T8529 T8531 punct ",",is
R6562 T8530 T8531 nsubj IL-12,is
R6563 T8531 T8531 ROOT is,is
R6564 T8532 T8531 acomp essential,is
R6565 T8533 T8531 prep during,is
R6566 T8534 T8535 preconj both,primary
R6567 T8535 T8539 amod primary,stimulation
R6568 T8536 T8535 cc and,primary
R6569 T8537 T8538 amod secondary,antigenic
R6570 T8538 T8535 conj antigenic,primary
R6571 T8539 T8533 pobj stimulation,during
R6572 T8540 T8539 prep for,stimulation
R6573 T8541 T8540 pobj production,for
R6574 T8542 T8541 prep of,production
R6575 T8543 T8542 pobj IL-10,of
R6576 T8544 T8531 prep by,is
R6577 T8545 T8546 amod Th1,cells
R6578 T8546 T8544 pobj cells,by
R6579 T8547 T8531 punct .,is
R6580 T8548 T8549 aux To,determine
R6581 T8549 T8561 advcl determine,differentiated
R6582 T8550 T8551 det the,requirements
R6583 T8551 T8549 dobj requirements,determine
R6584 T8552 T8551 prep for,requirements
R6585 T8553 T8552 pobj stability,for
R6586 T8554 T8553 prep of,stability
R6587 T8555 T8558 det the,cells
R6588 T8556 T8558 amod IL-10-producing,cells
R6589 T8557 T8558 amod Th1,cells
R6590 T8558 T8554 pobj cells,of
R6591 T8559 T8561 punct ",",differentiated
R6592 T8560 T8561 nsubj we,differentiated
R6593 T8561 T8561 ROOT differentiated,differentiated
R6594 T8562 T8565 compound CD4,cells
R6595 T8563 T8565 compound +,cells
R6596 T8564 T8565 compound T,cells
R6597 T8565 T8561 dobj cells,differentiated
R6598 T8566 T8561 prep for,differentiated
R6599 T8567 T8568 nummod 1,week
R6600 T8568 T8566 pobj week,for
R6601 T8569 T8561 prep with,differentiated
R6602 T8570 T8572 amod high,doses
R6603 T8571 T8572 compound antigen,doses
R6604 T8572 T8569 pobj doses,with
R6605 T8573 T8561 prep with,differentiated
R6606 T8574 T8573 cc or,with
R6607 T8575 T8573 conj without,with
R6608 T8576 T8575 pobj IL-12,without
R6609 T8577 T8579 punct (,4A
R6610 T8578 T8579 compound Figures,4A
R6611 T8579 T8576 appos 4A,IL-12
R6612 T8580 T8579 cc and,4A
R6613 T8581 T8579 conj 4C,4A
R6614 T8582 T8579 punct ),4A
R6615 T8583 T8576 punct ",",IL-12
R6616 T8584 T8561 conj washed,differentiated
R6617 T8585 T8584 dobj them,washed
R6618 T8586 T8584 punct ",",washed
R6619 T8587 T8584 cc and,washed
R6620 T8588 T8589 advmod then,restimulated
R6621 T8589 T8584 conj restimulated,washed
R6622 T8590 T8589 dobj them,restimulated
R6623 T8591 T8589 prep for,restimulated
R6624 T8592 T8594 det an,week
R6625 T8593 T8594 amod additional,week
R6626 T8594 T8591 pobj week,for
R6627 T8595 T8589 prep with,restimulated
R6628 T8596 T8599 det a,dose
R6629 T8597 T8598 amod low,antigen
R6630 T8598 T8599 compound antigen,dose
R6631 T8599 T8595 pobj dose,with
R6632 T8600 T8589 punct ",",restimulated
R6633 T8601 T8584 prep in,washed
R6634 T8602 T8603 det the,absence
R6635 T8603 T8601 pobj absence,in
R6636 T8604 T8603 cc or,absence
R6637 T8605 T8603 conj presence,absence
R6638 T8606 T8603 prep of,absence
R6639 T8607 T8606 pobj IL-12,of
R6640 T8608 T8610 punct (,4F
R6641 T8609 T8610 compound Figure,4F
R6642 T8610 T8607 appos 4F,IL-12
R6643 T8611 T8607 punct ),IL-12
R6644 T8612 T8561 punct .,differentiated
R6645 T8613 T8614 nummod Th1,cells
R6646 T8614 T8615 nsubj cells,induced
R6647 T8615 T8615 ROOT induced,induced
R6648 T8616 T8615 prep in,induced
R6649 T8617 T8619 det the,week
R6650 T8618 T8619 amod first,week
R6651 T8619 T8616 pobj week,in
R6652 T8620 T8621 aux to,produce
R6653 T8621 T8615 advcl produce,induced
R6654 T8622 T8621 dobj IL-10,produce
R6655 T8623 T8621 prep by,produce
R6656 T8624 T8623 pobj culture,by
R6657 T8625 T8621 prep with,produce
R6658 T8626 T8628 amod high,doses
R6659 T8627 T8628 compound antigen,doses
R6660 T8628 T8625 pobj doses,with
R6661 T8629 T8628 cc and,doses
R6662 T8630 T8628 conj IL-12,doses
R6663 T8631 T8615 conj lost,induced
R6664 T8632 T8633 poss their,ability
R6665 T8633 T8631 dobj ability,lost
R6666 T8634 T8635 aux to,express
R6667 T8635 T8633 acl express,ability
R6668 T8636 T8635 dobj IL-10,express
R6669 T8637 T8638 advmod when,recultured
R6670 T8638 T8635 advcl recultured,express
R6671 T8639 T8638 prep with,recultured
R6672 T8640 T8641 amod low,doses
R6673 T8641 T8639 pobj doses,with
R6674 T8642 T8641 prep of,doses
R6675 T8643 T8642 pobj OVA,of
R6676 T8644 T8643 punct ",",OVA
R6677 T8645 T8648 nsubjpass which,compensated
R6678 T8646 T8648 aux could,compensated
R6679 T8647 T8648 auxpass be,compensated
R6680 T8648 T8643 relcl compensated,OVA
R6681 T8649 T8648 prep for,compensated
R6682 T8650 T8631 punct ",",lost
R6683 T8651 T8631 prep to,lost
R6684 T8652 T8653 det some,extent
R6685 T8653 T8651 pobj extent,to
R6686 T8654 T8631 punct ",",lost
R6687 T8655 T8631 prep by,lost
R6688 T8656 T8655 pobj addition,by
R6689 T8657 T8656 prep of,addition
R6690 T8658 T8657 pobj IL-12,of
R6691 T8659 T8658 prep to,IL-12
R6692 T8660 T8662 det the,cultures
R6693 T8661 T8662 amod secondary,cultures
R6694 T8662 T8659 pobj cultures,to
R6695 T8663 T8664 punct (,Figure
R6696 T8664 T8662 appos Figure,cultures
R6697 T8665 T8664 nummod 4F,Figure
R6698 T8666 T8664 punct ),Figure
R6699 T8667 T8615 punct ",",induced
R6700 T8668 T8615 advmod again,induced
R6701 T8669 T8615 advcl suggesting,induced
R6702 T8670 T8676 mark that,cooperate
R6703 T8671 T8672 compound antigen,dose
R6704 T8672 T8675 nmod dose,signals
R6705 T8673 T8672 cc and,dose
R6706 T8674 T8672 conj IL-12,dose
R6707 T8675 T8676 nsubj signals,cooperate
R6708 T8676 T8669 ccomp cooperate,suggesting
R6709 T8677 T8676 prep for,cooperate
R6710 T8678 T8679 det the,induction
R6711 T8679 T8677 pobj induction,for
R6712 T8680 T8679 prep of,induction
R6713 T8681 T8680 pobj IL-10,of
R6714 T8682 T8615 punct .,induced
R6715 T8683 T8689 advmod Finally,cells
R6716 T8684 T8689 punct ",",cells
R6717 T8685 T8689 nsubj DO11,cells
R6718 T8686 T8689 nummod .10,cells
R6719 T8687 T8689 compound CD4,cells
R6720 T8688 T8689 compound +,cells
R6721 T8689 T8705 nsubj cells,produced
R6722 T8690 T8692 nsubjpass that,exposed
R6723 T8691 T8692 auxpass were,exposed
R6724 T8692 T8689 relcl exposed,cells
R6725 T8693 T8692 prep to,exposed
R6726 T8694 T8695 amod low,doses
R6727 T8695 T8693 pobj doses,to
R6728 T8696 T8695 prep of,doses
R6729 T8697 T8696 pobj antigen,of
R6730 T8698 T8697 cc and,antigen
R6731 T8699 T8695 conj IL-12,doses
R6732 T8700 T8692 prep during,exposed
R6733 T8701 T8704 det the,phase
R6734 T8702 T8704 amod primary,phase
R6735 T8703 T8704 compound differentiation,phase
R6736 T8704 T8700 pobj phase,during
R6737 T8705 T8705 ROOT produced,produced
R6738 T8706 T8707 amod high,amounts
R6739 T8707 T8705 dobj amounts,produced
R6740 T8708 T8707 prep of,amounts
R6741 T8709 T8708 pobj IFN-γ,of
R6742 T8710 T8709 cc but,IFN-γ
R6743 T8711 T8712 amod little,IL-10
R6744 T8712 T8709 conj IL-10,IFN-γ
R6745 T8713 T8705 punct ",",produced
R6746 T8714 T8705 cc but,produced
R6747 T8715 T8718 nsubjpass they,induced
R6748 T8716 T8718 aux could,induced
R6749 T8717 T8718 auxpass be,induced
R6750 T8718 T8705 conj induced,produced
R6751 T8719 T8720 aux to,produce
R6752 T8720 T8718 xcomp produce,induced
R6753 T8721 T8720 dobj IL-10,produce
R6754 T8722 T8729 advmod when,were
R6755 T8723 T8726 det both,dose
R6756 T8724 T8725 amod high,antigen
R6757 T8725 T8726 compound antigen,dose
R6758 T8726 T8729 nsubj dose,were
R6759 T8727 T8726 cc and,dose
R6760 T8728 T8726 conj IL-12,dose
R6761 T8729 T8720 advcl were,produce
R6762 T8730 T8729 acomp present,were
R6763 T8731 T8729 prep during,were
R6764 T8732 T8734 det the,phase
R6765 T8733 T8734 compound recall,phase
R6766 T8734 T8731 pobj phase,during
R6767 T8735 T8736 punct (,Figure
R6768 T8736 T8734 appos Figure,phase
R6769 T8737 T8736 nummod S4,Figure
R6770 T8738 T8736 punct ),Figure
R6771 T8739 T8718 punct .,induced
R6772 T8740 T8748 advmod Thus,required
R6773 T8741 T8748 punct ",",required
R6774 T8742 T8744 amod high,dose
R6775 T8743 T8744 compound antigen,dose
R6776 T8744 T8748 nsubjpass dose,required
R6777 T8745 T8744 cc and,dose
R6778 T8746 T8744 conj IL-12,dose
R6779 T8747 T8748 auxpass are,required
R6780 T8748 T8748 ROOT required,required
R6781 T8749 T8748 prep for,required
R6782 T8750 T8749 pcomp sustaining,for
R6783 T8751 T8752 det the,induction
R6784 T8752 T8750 dobj induction,sustaining
R6785 T8753 T8752 prep of,induction
R6786 T8754 T8755 compound IL-10,production
R6787 T8755 T8753 pobj production,of
R6788 T8756 T8752 prep by,induction
R6789 T8757 T8758 amod Th1,cells
R6790 T8758 T8756 pobj cells,by
R6791 T8759 T8748 punct .,required
R7613 T9893 T9894 compound IL-10,Production
R7614 T9894 T9898 nsubj Production,Requires
R7615 T9895 T9894 prep by,Production
R7616 T9896 T9897 compound Th1,Cells
R7617 T9897 T9895 pobj Cells,by
R7618 T9898 T9898 ROOT Requires,Requires
R7619 T9899 T9898 dobj ERK1,Requires
R7620 T9900 T9899 cc and,ERK1
R7621 T9901 T9899 conj ERK2,ERK1
R7622 T9902 T9905 nsubj Activation,showed
R7623 T9903 T9904 poss Our,data
R7624 T9904 T9905 nsubj data,showed
R7625 T9905 T9905 ROOT showed,showed
R7626 T9906 T9915 mark that,required
R7627 T9907 T9908 det the,maintenance
R7628 T9908 T9915 nsubj maintenance,required
R7629 T9909 T9908 prep of,maintenance
R7630 T9910 T9911 compound IL-10,induction
R7631 T9911 T9909 pobj induction,of
R7632 T9912 T9911 prep in,induction
R7633 T9913 T9914 amod Th1,cells
R7634 T9914 T9912 pobj cells,in
R7635 T9915 T9905 ccomp required,showed
R7636 T9916 T9915 dobj stimulation,required
R7637 T9917 T9916 prep with,stimulation
R7638 T9918 T9920 amod high,dose
R7639 T9919 T9920 compound antigen,dose
R7640 T9920 T9917 pobj dose,with
R7641 T9921 T9920 punct ",",dose
R7642 T9922 T9928 dobj which,compensated
R7643 T9923 T9928 prep to,compensated
R7644 T9924 T9925 det some,extent
R7645 T9925 T9928 nsubjpass extent,compensated
R7646 T9926 T9928 aux could,compensated
R7647 T9927 T9928 auxpass be,compensated
R7648 T9928 T9920 relcl compensated,dose
R7649 T9929 T9928 prep for,compensated
R7650 T9930 T9928 agent by,compensated
R7651 T9931 T9932 det the,addition
R7652 T9932 T9930 pobj addition,by
R7653 T9933 T9932 prep of,addition
R7654 T9934 T9933 pobj IL-12,of
R7655 T9935 T9905 punct .,showed
R7656 T9936 T9945 nsubj Signaling,induced
R7657 T9937 T9936 prep through,Signaling
R7658 T9938 T9939 det the,TCR
R7659 T9939 T9937 pobj TCR,through
R7660 T9940 T9936 prep with,Signaling
R7661 T9941 T9942 amod high,doses
R7662 T9942 T9940 pobj doses,with
R7663 T9943 T9942 prep of,doses
R7664 T9944 T9943 pobj antigen,of
R7665 T9945 T9945 ROOT induced,induced
R7666 T9946 T9950 amod stronger,activation
R7667 T9947 T9950 nsubj ERK1,activation
R7668 T9948 T9947 cc and,ERK1
R7669 T9949 T9947 conj ERK2,ERK1
R7670 T9950 T9945 dobj activation,induced
R7671 T9951 T9950 prep than,activation
R7672 T9952 T9951 pobj that,than
R7673 T9953 T9952 acl induced,that
R7674 T9954 T9953 agent by,induced
R7675 T9955 T9957 amod low,dose
R7676 T9956 T9957 compound antigen,dose
R7677 T9957 T9954 pobj dose,by
R7678 T9958 T9957 punct ",",dose
R7679 T9959 T9961 preconj not,in
R7680 T9960 T9959 advmod only,not
R7681 T9961 T9953 prep in,induced
R7682 T9962 T9966 amod naive,cells
R7683 T9963 T9966 nmod CD4,cells
R7684 T9964 T9966 nummod +,cells
R7685 T9965 T9966 compound T,cells
R7686 T9966 T9961 pobj cells,in
R7687 T9967 T9966 punct (,cells
R7688 T9968 T9978 nmod data,al.
R7689 T9969 T9970 neg not,shown
R7690 T9970 T9968 acl shown,data
R7691 T9971 T9970 punct ),shown
R7692 T9972 T9974 mark as,demonstrated
R7693 T9973 T9974 advmod previously,demonstrated
R7694 T9974 T9968 advcl demonstrated,data
R7695 T9975 T9978 punct (,al.
R7696 T9976 T9978 nmod Jorritsma,al.
R7697 T9977 T9978 nmod et,al.
R7698 T9978 T9966 appos al.,cells
R7699 T9979 T9978 punct ",",al.
R7700 T9980 T9978 npadvmod 2003,al.
R7701 T9981 T9978 punct ),al.
R7702 T9982 T9978 cc but,al.
R7703 T9983 T9982 advmod also,but
R7704 T9984 T9989 prep in,restimulated
R7705 T9985 T9988 nummod CD4,cells
R7706 T9986 T9988 nummod +,cells
R7707 T9987 T9988 compound T,cells
R7708 T9988 T9984 pobj cells,in
R7709 T9989 T9978 conj restimulated,al.
R7710 T9990 T9989 prep with,restimulated
R7711 T9991 T9997 det the,doses
R7712 T9992 T9997 amod same,doses
R7713 T9993 T9996 amod high,antigen
R7714 T9994 T9993 cc and,high
R7715 T9995 T9993 conj low,high
R7744 T10024 T10025 amod high,antigen
R7745 T10025 T10026 compound antigen,dose
R7746 T10026 T10027 nsubj dose,differentiated
R7747 T10027 T10022 conj differentiated,was
R7748 T10028 T10029 nummod Th1,cells
R7749 T10029 T10027 dobj cells,differentiated
R7750 T10030 T10031 advmod always,showed
R7751 T10031 T10027 conj showed,differentiated
R7752 T10032 T10035 amod enhanced,ERK1
R7753 T10033 T10032 cc and,enhanced
R7754 T10034 T10032 conj prolonged,enhanced
R7755 T10035 T10031 dobj ERK1,showed
R7756 T10036 T10035 cc and,ERK1
R7757 T10037 T10038 nummod ERK2,activation
R7758 T10038 T10035 conj activation,ERK1
R7759 T10039 T10038 prep in,activation
R7760 T10040 T10041 det the,presence
R7761 T10041 T10039 pobj presence,in
R7762 T10042 T10041 prep of,presence
R7763 T10043 T10042 pobj IL-12,of
R7764 T10044 T10027 punct ",",differentiated
R7765 T10045 T10027 advmod regardless,differentiated
R7766 T10046 T10045 prep of,regardless
R7767 T10047 T10050 mark whether,restimulated
R7768 T10048 T10050 nsubjpass they,restimulated
R7769 T10049 T10050 auxpass were,restimulated
R7770 T10050 T10046 pcomp restimulated,of
R7771 T10051 T10050 prep with,restimulated
R7772 T10052 T10056 amod high,dose
R7773 T10053 T10052 cc or,high
R7774 T10054 T10052 conj low,high
R7775 T10055 T10056 compound antigen,dose
R7776 T10056 T10051 pobj dose,with
R7777 T10057 T10056 punct (,dose
R7778 T10058 T10059 compound Figure,5B
R7779 T10059 T10056 appos 5B,dose
R7780 T10060 T10056 punct ),dose
R7781 T10061 T10027 punct .,differentiated
R7782 T10062 T10064 nsubj We,investigated
R7783 T10063 T10064 advmod then,investigated
R7784 T10064 T10064 ROOT investigated,investigated
R7785 T10065 T10071 mark whether,required
R7786 T10066 T10069 nmod ERK1,activation
R7787 T10067 T10066 cc and,ERK1
R7788 T10068 T10066 conj ERK2,ERK1
R7789 T10069 T10071 nsubjpass activation,required
R7790 T10070 T10071 auxpass was,required
R7791 T10071 T10064 ccomp required,investigated
R7792 T10072 T10071 prep for,required
R7793 T10073 T10074 det the,induction
R7794 T10074 T10072 pobj induction,for
R7795 T10075 T10074 prep of,induction
R7796 T10076 T10075 pobj IL-10,of
R7797 T10077 T10074 prep in,induction
R7798 T10078 T10079 compound Th1,cells
R7799 T10079 T10077 pobj cells,in
R7800 T10080 T10071 prep by,required
R7801 T10081 T10080 pcomp using,by
R7802 T10082 T10081 dobj U0126,using
R7803 T10083 T10085 punct (,5C
R7804 T10084 T10085 compound Figure,5C
R7805 T10085 T10082 appos 5C,U0126
R7806 T10086 T10085 punct ),5C
R7807 T10087 T10082 punct ",",U0126
R7808 T10088 T10089 det a,compound
R7809 T10089 T10082 appos compound,U0126
R7810 T10090 T10091 nsubj that,blocks
R7811 T10091 T10089 relcl blocks,compound
R7812 T10092 T10094 amod downstream,activation
R7813 T10093 T10094 compound ERK,activation
R7814 T10094 T10091 dobj activation,blocks
R7815 T10095 T10064 punct .,investigated
R7816 T10096 T10097 aux To,ensure
R7817 T10097 T10110 advcl ensure,used
R7818 T10098 T10105 mark that,affected
R7819 T10099 T10102 advmod only,signaling
R7820 T10100 T10101 compound T,cell
R7821 T10101 T10102 compound cell,signaling
R7822 T10102 T10105 nsubjpass signaling,affected
R7823 T10103 T10105 aux was,affected
R7824 T10104 T10105 auxpass being,affected
R7825 T10105 T10097 ccomp affected,ensure
R7826 T10106 T10105 agent by,affected
R7827 T10107 T10106 pobj U0126,by
R7828 T10108 T10110 punct ",",used
R7829 T10109 T10110 nsubj we,used
R7830 T10110 T10110 ROOT used,used
R7831 T10111 T10113 det an,system
R7832 T10112 T10113 amod APC-free,system
R7833 T10113 T10110 dobj system,used
R7834 T10114 T10120 prep in,differentiated
R7835 T10115 T10114 pobj which,in
R7836 T10116 T10118 det the,cells
R7837 T10117 T10118 compound T,cells
R7838 T10118 T10120 nsubjpass cells,differentiated
R7839 T10119 T10120 auxpass were,differentiated
R7840 T10120 T10113 relcl differentiated,system
R7841 T10121 T10120 prep in,differentiated
R7842 T10122 T10123 det the,presence
R7843 T10123 T10121 pobj presence,in
R7864 T10144 T10140 appos stimulation,cultures
R7865 T10145 T10146 advmod together,with
R7866 T10146 T10148 nsubj with,led
R7867 T10147 T10146 pobj IL-12,with
R7868 T10148 T10148 ROOT led,led
R7869 T10149 T10148 prep to,led
R7870 T10150 T10151 amod higher,percentages
R7871 T10151 T10149 pobj percentages,to
R7872 T10152 T10151 prep of,percentages
R7873 T10153 T10152 pobj cells,of
R7874 T10154 T10153 acl producing,cells
R7875 T10155 T10156 preconj both,IL-10
R7876 T10156 T10154 dobj IL-10,producing
R7877 T10157 T10156 cc and,IL-10
R7878 T10158 T10156 conj IFN-γ,IL-10
R7879 T10159 T10148 prep after,led
R7880 T10160 T10161 nummod 1,week
R7881 T10161 T10159 pobj week,after
R7882 T10162 T10161 prep of,week
R7883 T10163 T10162 pobj culture,of
R7884 T10164 T10166 punct (,5C
R7885 T10165 T10166 compound Figure,5C
R7886 T10166 T10163 appos 5C,culture
R7887 T10167 T10148 punct ),led
R7888 T10168 T10148 punct .,led
R7889 T10169 T10175 nsubj Addition,abrogated
R7890 T10170 T10169 prep of,Addition
R7891 T10171 T10170 pobj U0126,of
R7892 T10172 T10169 prep to,Addition
R7893 T10173 T10174 det the,cultures
R7894 T10174 T10172 pobj cultures,to
R7895 T10175 T10175 ROOT abrogated,abrogated
R7896 T10176 T10177 det the,production
R7897 T10177 T10175 dobj production,abrogated
R7898 T10178 T10177 prep of,production
R7899 T10179 T10178 pobj IL-10,of
R7900 T10180 T10175 prep at,abrogated
R7901 T10181 T10182 det all,doses
R7902 T10182 T10180 pobj doses,at
R7903 T10183 T10182 prep of,doses
R7904 T10184 T10183 pobj anti-CD3,of
R7905 T10185 T10187 punct (,5C
R7906 T10186 T10187 compound Figure,5C
R7907 T10187 T10184 appos 5C,anti-CD3
R7908 T10188 T10184 punct ),anti-CD3
R7909 T10189 T10175 punct .,abrogated
R7910 T10190 T10192 mark Because,inhibits
R7911 T10191 T10192 nsubj U0126,inhibits
R7912 T10192 T10192 ROOT inhibits,inhibits
R7913 T10193 T10195 det the,activation
R7914 T10194 T10195 amod MEK5-catalyzed,activation
R7915 T10195 T10192 dobj activation,inhibits
R7916 T10196 T10195 prep of,activation
R7917 T10197 T10196 pobj ERK5,of
R7918 T10198 T10192 punct ",",inhibits
R7919 T10199 T10201 advmod as,as
R7920 T10200 T10201 advmod well,as
R7921 T10201 T10192 cc as,inhibits
R7922 T10202 T10203 det the,MEK1
R7923 T10203 T10192 dobj MEK1,inhibits
R7924 T10204 T10203 punct -,MEK1
R7925 T10205 T10203 cc and,MEK1
R7926 T10206 T10207 amod MEK2-catalyzed,activation
R7927 T10207 T10203 conj activation,MEK1
R7928 T10208 T10207 prep of,activation
R7929 T10209 T10208 pobj ERK1,of
R7930 T10210 T10209 cc and,ERK1
R7931 T10211 T10209 conj ERK2,ERK1
R7932 T10212 T10228 punct (,used
R7933 T10213 T10215 compound Bain,al.
R7934 T10214 T10215 nmod et,al.
R7935 T10215 T10228 ccomp al.,used
R7936 T10216 T10215 punct ",",al.
R7937 T10217 T10215 npadvmod 2007,al.
R7938 T10218 T10228 punct ;,used
R7939 T10219 T10221 compound Mody,al.
R7940 T10220 T10221 compound et,al.
R7941 T10221 T10228 npadvmod al.,used
R7942 T10222 T10221 punct ",",al.
R7943 T10223 T10221 npadvmod 2001,al.
R7944 T10224 T10221 punct ),al.
R7945 T10225 T10228 punct ",",used
R7946 T10226 T10228 nsubj we,used
R7947 T10227 T10228 advmod also,used
R7948 T10228 T10228 ROOT used,used
R7949 T10229 T10235 det the,MEK1
R7950 T10230 T10231 advmod more,specific
R7951 T10231 T10235 amod specific,MEK1
R7952 T10232 T10235 punct ",",MEK1
R7953 T10233 T10234 advmod structurally,unrelated
R7954 T10234 T10235 amod unrelated,MEK1
R7955 T10235 T10228 dobj MEK1,used
R7956 T10236 T10235 cc and,MEK1
R7957 T10237 T10238 compound MEK2,inhibitor
R7958 T10238 T10239 compound inhibitor,PD184352
R7959 T10239 T10235 conj PD184352,MEK1
R7960 T10240 T10228 prep at,used
R7961 T10241 T10240 pobj concentrations,at
R7962 T10242 T10245 prep in,inhibits
R7963 T10243 T10242 pobj which,in
R7964 T10244 T10245 nsubj it,inhibits
R7965 T10245 T10245 ROOT inhibits,inhibits
R7966 T10246 T10245 dobj MEK1,inhibits
R7967 T10247 T10246 cc and,MEK1
R7968 T10248 T10246 conj MEK2,MEK1
R7969 T10249 T10248 cc but,MEK2
R7970 T10250 T10261 neg not,al.
R7971 T10251 T10261 nmod MEK5,al.
R7972 T10252 T10261 punct (,al.
R7973 T10253 T10255 compound Bain,al.
R7974 T10254 T10255 nmod et,al.
R7975 T10255 T10261 ccomp al.,al.
R7976 T10256 T10255 punct ",",al.
R7977 T10257 T10255 npadvmod 2007,al.
R7978 T10258 T10261 punct ;,al.
R7979 T10259 T10261 compound Mody,al.
R7980 T10260 T10261 nmod et,al.
R7981 T10261 T10248 conj al.,MEK2
R7982 T10262 T10261 punct ",",al.
R7983 T10263 T10261 npadvmod 2001,al.
R7984 T10264 T10261 punct ),al.
R7985 T10265 T10228 punct .,used
R7986 T10266 T10267 nsubj PD184352,caused
R7987 T10267 T10267 ROOT caused,caused
R7988 T10268 T10270 det a,inhibition
R7989 T10269 T10270 amod similar,inhibition
R7990 T10270 T10267 dobj inhibition,caused
R7991 T10271 T10270 prep of,inhibition
R7992 T10272 T10273 amod IL-10,production
R7993 T10273 T10271 pobj production,of
R7994 T10274 T10273 prep by,production
R7995 T10275 T10276 amod Th1,cells
R7996 T10276 T10274 pobj cells,by
R7997 T10277 T10267 prep in,caused
R7998 T10278 T10280 det a,fashion
R7999 T10279 T10280 amod dose-dependent,fashion
R8000 T10280 T10277 pobj fashion,in
R8001 T10281 T10282 punct (,Figure
R8002 T10282 T10280 appos Figure,fashion
R8003 T10283 T10282 nummod 5D,Figure
R8004 T10284 T10282 cc and,Figure
R8005 T10285 T10286 compound Figure,S5A
R8006 T10286 T10282 conj S5A,Figure
R8007 T10287 T10267 punct ),caused
R8008 T10288 T10267 punct .,caused
R8009 T10289 T10326 prep Upon,observed
R8010 T10290 T10289 pobj addition,Upon
R8011 T10291 T10290 prep of,addition
R8012 T10292 T10291 pobj inhibitors,of
R8013 T10293 T10290 prep to,addition
R8014 T10294 T10296 amod other,pathways
R8015 T10295 T10296 amod signaling,pathways
R8016 T10296 T10293 pobj pathways,to
R8017 T10297 T10296 punct ",",pathways
R8018 T10298 T10296 prep including,pathways
R8019 T10299 T10302 det a,inhibitor
R8020 T10300 T10302 amod p38,inhibitor
R8021 T10301 T10302 compound MAPK,inhibitor
R8022 T10302 T10298 pobj inhibitor,including
R8023 T10303 T10302 punct ",",inhibitor
R8024 T10304 T10302 appos SB203580,inhibitor
R8025 T10305 T10304 punct ",",SB203580
R8026 T10306 T10304 cc or,SB203580
R8027 T10307 T10309 det the,inhibitor
R8028 T10308 T10309 compound GSK3β,inhibitor
R8029 T10309 T10304 conj inhibitor,SB203580
R8030 T10310 T10309 punct ",",inhibitor
R8070 T10350 T10335 ccomp requires,suggested
R8071 T10351 T10350 dobj ERK1,requires
R8072 T10352 T10351 cc and,ERK1
R8073 T10353 T10351 conj ERK2,ERK1
R8074 T10354 T10350 advcl signaling,requires
R8075 T10355 T10354 punct ",",signaling
R8076 T10356 T10354 cc but,signaling
R8077 T10357 T10359 neg not,activation
R8078 T10358 T10359 det the,activation
R8079 T10359 T10354 conj activation,signaling
R8080 T10360 T10359 prep of,activation
R8081 T10361 T10362 det the,p38
R8082 T10362 T10360 pobj p38,of
R8083 T10363 T10362 cc or,p38
R8084 T10364 T10366 det the,pathways
R8085 T10365 T10366 compound GSK3β,pathways
R8086 T10366 T10362 conj pathways,p38
R8087 T10367 T10335 punct .,suggested
R8665 T11223 T11224 compound IL-10,Production
R8666 T11224 T11224 ROOT Production,Production
R8667 T11225 T11224 prep by,Production
R8668 T11226 T11225 pobj Th2,by
R8669 T11227 T11226 cc and,Th2
R8670 T11228 T11229 compound Th17,Cells
R8671 T11229 T11226 conj Cells,Th2
R8672 T11230 T11231 advmod Also,Requires
R8673 T11231 T11231 ROOT Requires,Requires
R8674 T11232 T11235 nummod ERK1,Activation
R8675 T11233 T11232 cc and,ERK1
R8676 T11234 T11232 conj ERK2,ERK1
R8677 T11235 T11231 dobj Activation,Requires
R8678 T11236 T11237 aux To,address
R8679 T11237 T11256 advcl address,differentiated
R8680 T11238 T11246 mark whether,was
R8681 T11239 T11240 compound IL-10,production
R8682 T11240 T11246 nsubj production,was
R8683 T11241 T11240 prep by,production
R8684 T11242 T11245 nmod Th2,cells
R8685 T11243 T11242 cc and,Th2
R8686 T11244 T11242 conj Th17,Th2
R8687 T11245 T11241 pobj cells,by
R8688 T11246 T11237 ccomp was,address
R8689 T11247 T11246 advmod also,was
R8690 T11248 T11246 acomp dependent,was
R8691 T11249 T11248 prep on,dependent
R8692 T11250 T11253 nummod ERK1,activation
R8693 T11251 T11250 cc and,ERK1
R8694 T11252 T11250 conj ERK2,ERK1
R8695 T11253 T11249 pobj activation,on
R8696 T11254 T11256 punct ",",differentiated
R8697 T11255 T11256 nsubj we,differentiated
R8698 T11256 T11231 conj differentiated,Requires
R8699 T11257 T11258 det these,cells
R8700 T11258 T11256 dobj cells,differentiated
R8701 T11259 T11256 prep with,differentiated
R8702 T11260 T11277 nmod anti-CD3,al.
R8703 T11261 T11260 cc and,anti-CD3
R8704 T11262 T11260 conj anti-CD28,anti-CD3
R8705 T11263 T11260 prep in,anti-CD3
R8706 T11264 T11265 det the,absence
R8707 T11265 T11263 pobj absence,in
R8708 T11266 T11265 prep of,absence
R8709 T11267 T11266 pobj APCs,of
R8710 T11268 T11271 punct (,al.
R8711 T11269 T11271 compound Shoemaker,al.
R8712 T11270 T11271 nmod et,al.
R8713 T11271 T11265 appos al.,absence
R8714 T11272 T11271 punct ",",al.
R8715 T11273 T11271 npadvmod 2006,al.
R8716 T11274 T11271 punct ;,al.
R8732 T11290 T11288 pobj presence,in
R8733 T11291 T11290 cc or,presence
R8734 T11292 T11290 conj absence,presence
R8735 T11293 T11292 prep of,absence
R8736 T11294 T11296 det the,inhibitor
R8737 T11295 T11296 compound MEK,inhibitor
R8738 T11296 T11293 pobj inhibitor,of
R8739 T11297 T11298 punct (,PD184352
R8740 T11298 T11296 appos PD184352,inhibitor
R8741 T11299 T11256 punct ),differentiated
R8742 T11300 T11256 punct .,differentiated
R8743 T11301 T11302 nsubj We,showed
R8744 T11302 T11302 ROOT showed,showed
R8745 T11303 T11308 mark that,is
R8746 T11304 T11307 nummod ERK1,activation
R8747 T11305 T11304 cc and,ERK1
R8748 T11306 T11304 conj ERK2,ERK1
R8749 T11307 T11308 nsubj activation,is
R8750 T11308 T11302 ccomp is,showed
R8751 T11309 T11311 det a,pathway
R8752 T11310 T11311 amod common,pathway
R8753 T11311 T11308 attr pathway,is
R8754 T11312 T11311 acl required,pathway
R8755 T11313 T11312 prep for,required
R8756 T11314 T11313 pobj induction,for
R8757 T11315 T11314 prep of,induction
R8758 T11316 T11315 pobj IL-10,of
R8759 T11317 T11312 prep in,required
R8760 T11318 T11321 amod different,subsets
R8761 T11319 T11320 compound Th,cell
R8762 T11320 T11321 compound cell,subsets
R8763 T11321 T11317 pobj subsets,in
R8764 T11322 T11333 mark because,inhibited
R8765 T11323 T11324 compound IL-10,production
R8766 T11324 T11333 nsubjpass production,inhibited
R8767 T11325 T11324 prep by,production
R8768 T11326 T11327 preconj both,Th2
R8769 T11327 T11330 nmod Th2,cells
R8770 T11328 T11327 cc and,Th2
R8771 T11329 T11327 conj Th17,Th2
R8772 T11330 T11325 pobj cells,by
R8773 T11331 T11333 auxpass was,inhibited
R8774 T11332 T11333 advmod markedly,inhibited
R8775 T11333 T11312 advcl inhibited,required
R8776 T11334 T11333 prep in,inhibited
R8777 T11335 T11336 det the,presence
R8778 T11336 T11334 pobj presence,in
R8779 T11337 T11336 prep of,presence
R8780 T11338 T11340 det the,inhibitor
R8781 T11339 T11340 compound MEK,inhibitor
R8782 T11340 T11337 pobj inhibitor,of
R8783 T11341 T11340 punct (,inhibitor
R8784 T11342 T11340 appos PD184352,inhibitor
R8785 T11343 T11302 punct ),showed
R8786 T11344 T11345 punct (,Figure
R8787 T11345 T11345 ROOT Figure,Figure
R8788 T11346 T11345 nummod 5D,Figure
R8789 T11347 T11345 cc and,Figure
R8790 T11348 T11349 compound Figure,S5B
R8791 T11349 T11345 conj S5B,Figure
R8792 T11350 T11345 punct ),Figure
R8793 T11351 T11345 punct .,Figure
R8794 T11352 T11365 prep In,affect
R8795 T11353 T11352 pobj contrast,In
R8796 T11354 T11365 punct ",",affect
R8797 T11355 T11365 nsubj inhibitors,affect
R8798 T11356 T11355 prep of,inhibitors
R8799 T11357 T11358 nummod p38,MAPK
R8800 T11358 T11356 pobj MAPK,of
R8801 T11359 T11356 cc or,of
R8802 T11360 T11356 conj of,of
R8803 T11361 T11362 amod GSK-3β,activation
R8804 T11362 T11360 pobj activation,of
R8805 T11363 T11365 aux did,affect
R8806 T11364 T11365 neg not,affect
R8807 T11365 T11365 ROOT affect,affect
R8808 T11366 T11367 det the,expression
R8809 T11367 T11365 dobj expression,affect
R8810 T11368 T11367 prep of,expression
R8811 T11369 T11368 pobj IL-10,of
R8812 T11370 T11365 prep by,affect
R8813 T11371 T11372 det these,subsets
R8814 T11372 T11370 pobj subsets,by
R8815 T11373 T11374 punct (,Figure
R8816 T11374 T11372 appos Figure,subsets
R8817 T11375 T11374 nummod S5B,Figure
R8818 T11376 T11374 punct ),Figure
R8819 T11377 T11365 punct .,affect
R8820 T11378 T11385 nmod Activation,pathway
R8821 T11379 T11378 prep of,Activation
R8822 T11380 T11381 det the,ERK1
R8823 T11381 T11379 pobj ERK1,of
R8824 T11382 T11381 cc and,ERK1
R8825 T11383 T11385 compound ERK2,pathway
R8826 T11384 T11385 amod signaling,pathway
R8827 T11385 T11386 nsubj pathway,is
R8828 T11386 T11386 ROOT is,is
R8829 T11387 T11386 advmod therefore,is
R8830 T11388 T11390 det a,requirement
R8831 T11389 T11390 amod common,requirement
R8832 T11390 T11386 attr requirement,is
R8833 T11391 T11390 prep for,requirement
R8834 T11392 T11393 det the,induction
R8835 T11393 T11391 pobj induction,for
R8836 T11394 T11393 prep of,induction
R8837 T11395 T11396 compound IL-10,production
R8838 T11396 T11394 pobj production,of
R8839 T11397 T11396 prep by,production
R8840 T11398 T11397 pobj Th1,by
R8841 T11399 T11398 punct ",",Th1
R8842 T11400 T11398 conj Th2,Th1
R8843 T11401 T11400 punct ",",Th2
R8844 T11402 T11400 cc and,Th2
R8845 T11403 T11400 conj Th17,Th2
R8846 T11404 T11397 pobj cells,by
R8847 T11405 T11386 punct .,is
R9726 T12523 T12525 amod c-maf,Correlates
R9727 T12524 T12525 compound Expression,Correlates
R9728 T12525 T12538 nsubj Correlates,investigate
R9729 T12526 T12525 prep with,Correlates
R9730 T12527 T12528 compound IL-10,Production
R9731 T12528 T12526 pobj Production,with
R9732 T12529 T12528 prep in,Production
R9733 T12530 T12529 pobj Th1,in
R9734 T12531 T12530 punct ",",Th1
R9735 T12532 T12530 conj Th2,Th1
R9736 T12533 T12532 punct ",",Th2
R9737 T12534 T12532 cc and,Th2
R9738 T12535 T12536 compound Th17,Cells
R9739 T12536 T12538 nsubj Cells,investigate
R9740 T12537 T12538 aux To,investigate
R9741 T12538 T12550 advcl investigate,differentiated
R9742 T12539 T12542 advmod further,factors
R9743 T12540 T12542 det the,factors
R9744 T12541 T12542 amod downstream,factors
R9745 T12542 T12538 dobj factors,investigate
R9746 T12543 T12542 acl involved,factors
R9747 T12544 T12543 prep in,involved
R9748 T12545 T12544 pcomp regulating,in
R9749 T12546 T12547 amod IL-10,production
R9750 T12547 T12545 dobj production,regulating
R9751 T12548 T12550 punct ",",differentiated
R9752 T12549 T12550 nsubj we,differentiated
R9753 T12550 T12550 ROOT differentiated,differentiated
R9754 T12551 T12552 quantmod DO11,.10
R9755 T12552 T12556 nummod .10,cells
R9756 T12553 T12556 compound CD4,cells
R9757 T12554 T12556 nummod +,cells
R9758 T12555 T12556 compound T,cells
R9759 T12556 T12550 dobj cells,differentiated
R9760 T12557 T12556 prep with,cells
R9761 T12558 T12559 amod increasing,doses
R9762 T12559 T12557 pobj doses,with
R9763 T12560 T12559 prep of,doses
R9764 T12561 T12560 pobj OVA,of
R9765 T12562 T12550 punct ",",differentiated
R9766 T12563 T12550 prep in,differentiated
R9767 T12564 T12565 det the,presence
R9768 T12565 T12563 pobj presence,in
R9769 T12566 T12565 cc or,presence
R9770 T12567 T12565 conj absence,presence
R9771 T12568 T12567 prep of,absence
R9772 T12569 T12568 pobj IL-12,of
R9773 T12570 T12567 punct ",",absence
R9774 T12571 T12550 cc and,differentiated
R9775 T12572 T12550 conj quantified,differentiated
R9776 T12573 T12574 det the,expression
R9777 T12574 T12572 dobj expression,quantified
R9778 T12575 T12574 prep of,expression
R9779 T12576 T12575 pobj cytokines,of
R9780 T12577 T12576 cc and,cytokines
R9781 T12578 T12579 compound transcription,factors
R9782 T12579 T12576 conj factors,cytokines
R9783 T12580 T12574 prep by,expression
R9784 T12581 T12582 amod real-time,RT-PCR
R9785 T12582 T12580 pobj RT-PCR,by
R9786 T12583 T12550 punct .,differentiated
R9787 T12584 T12585 amod Low-dose,antigen
R9788 T12585 T12586 nsubj antigen,resulted
R9789 T12586 T12586 ROOT resulted,resulted
R9790 T12587 T12586 prep in,resulted
R9791 T12588 T12587 pobj transcription,in
R9792 T12589 T12588 prep of,transcription
R9793 T12590 T12589 pobj Il4,of
R9794 T12591 T12586 cc and,resulted
R9795 T12592 T12594 nsubjpass this,abrogated
R9796 T12593 T12594 auxpass was,abrogated
R9797 T12594 T12586 conj abrogated,resulted
R9798 T12595 T12594 agent by,abrogated
R9799 T12596 T12599 det both,doses
R9800 T12597 T12598 amod high,antigen
R9801 T12598 T12599 compound antigen,doses
R9802 T12599 T12595 pobj doses,by
R9803 T12600 T12599 cc and,doses
R9804 T12601 T12604 compound IL-12,6A
R9805 T12602 T12603 punct (,Figure
R9806 T12603 T12604 compound Figure,6A
R9807 T12604 T12599 conj 6A,doses
R9808 T12605 T12594 punct ),abrogated
R9809 T12606 T12586 punct .,resulted
R9810 T12607 T12609 det A,amount
R9811 T12608 T12609 amod low,amount
R9812 T12609 T12615 nsubjpass amount,induced
R9813 T12610 T12609 prep of,amount
R9814 T12611 T12610 pobj transcription,of
R9815 T12612 T12611 prep of,transcription
R9816 T12613 T12612 pobj Ifnγ,of
R9817 T12614 T12615 auxpass was,induced
R9818 T12615 T12615 ROOT induced,induced
R9819 T12616 T12615 agent by,induced
R9820 T12617 T12616 pobj IL-12,by
R9821 T12618 T12621 advmod when,differentiated
R9822 T12619 T12621 nsubjpass cells,differentiated
R9823 T12620 T12621 auxpass were,differentiated
R9824 T12621 T12615 advcl differentiated,induced
R9825 T12622 T12621 prep with,differentiated
R9826 T12623 T12625 amod low,dose
R9827 T12624 T12625 compound antigen,dose
R9828 T12625 T12622 pobj dose,with
R9829 T12626 T12615 punct ",",induced
R9830 T12627 T12615 cc but,induced
R9831 T12628 T12629 det this,effect
R9832 T12629 T12634 nsubjpass effect,upregulated
R9833 T12630 T12629 prep of,effect
R9834 T12631 T12630 pobj IL-12,of
R9835 T12632 T12634 auxpass was,upregulated
R9836 T12633 T12634 advmod markedly,upregulated
R9837 T12634 T12615 conj upregulated,induced
R9838 T12635 T12634 prep with,upregulated
R9839 T12636 T12637 amod increasing,doses
R9840 T12637 T12635 pobj doses,with
R9841 T12638 T12637 prep of,doses
R9842 T12639 T12642 compound antigen,6A
R9843 T12640 T12641 punct (,Figure
R9844 T12641 T12642 compound Figure,6A
R9845 T12642 T12638 pobj 6A,of
R9846 T12643 T12634 punct ),upregulated
R9847 T12644 T12634 punct .,upregulated
R9848 T12645 T12647 det A,amount
R9849 T12646 T12647 amod low,amount
R9850 T12647 T12652 nsubjpass amount,observed
R9851 T12648 T12647 prep of,amount
R9852 T12649 T12650 amod Il10,transcription
R9853 T12650 T12648 pobj transcription,of
R9854 T12651 T12652 auxpass was,observed
R9855 T12652 T12652 ROOT observed,observed
R9856 T12653 T12652 prep at,observed
R9857 T12654 T12655 amod low,doses
R9858 T12655 T12653 pobj doses,at
R9859 T12656 T12655 prep of,doses
R9860 T12657 T12656 pobj antigen,of
R9861 T12658 T12655 acl accompanying,doses
R9862 T12659 T12660 amod Il4,expression
R9863 T12660 T12658 dobj expression,accompanying
R9864 T12661 T12660 punct (,expression
R9865 T12662 T12664 amod Th2,response
R9866 T12663 T12664 compound cell,response
R9867 T12664 T12660 appos response,expression
R9868 T12665 T12660 punct ),expression
R9869 T12666 T12652 punct ",",observed
R9870 T12667 T12652 cc and,observed
R9871 T12668 T12670 nsubjpass this,abrogated
R9872 T12669 T12670 auxpass was,abrogated
R9873 T12670 T12652 conj abrogated,observed
R9874 T12671 T12670 agent by,abrogated
R9875 T12672 T12673 amod increased,doses
R9876 T12673 T12671 pobj doses,by
R9877 T12674 T12673 prep of,doses
R9878 T12675 T12674 pobj antigen,of
R9879 T12676 T12677 mark as,was
R9880 T12677 T12670 advcl was,abrogated
R9881 T12678 T12679 amod Il4,expression
R9882 T12679 T12677 attr expression,was
R9883 T12680 T12682 punct (,6A
R9884 T12681 T12682 compound Figure,6A
R9885 T12682 T12679 appos 6A,expression
R9886 T12683 T12670 punct ),abrogated
R9887 T12684 T12652 punct .,observed
R9888 T12685 T12692 prep At,had
R9889 T12686 T12687 amod low,doses
R9890 T12687 T12685 pobj doses,At
R9891 T12688 T12687 prep of,doses
R9892 T12689 T12688 pobj antigen,of
R9893 T12690 T12692 punct ",",had
R9894 T12691 T12692 nsubj IL-12,had
R9895 T12692 T12692 ROOT had,had
R9896 T12693 T12694 amod little,effect
R9897 T12694 T12692 dobj effect,had
R9898 T12695 T12696 aux to,increase
R9899 T12696 T12694 acl increase,effect
R9900 T12697 T12698 compound IL-10,mRNA
R9901 T12698 T12699 compound mRNA,expression
R9902 T12699 T12696 dobj expression,increase
R9903 T12700 T12702 punct (,6A
R9904 T12701 T12702 compound Figure,6A
R9905 T12702 T12699 appos 6A,expression
R9906 T12703 T12702 punct ),6A
R9907 T12704 T12696 prep in,increase
R9908 T12705 T12704 pobj keeping,in
R9909 T12706 T12705 prep with,keeping
R9910 T12707 T12709 det the,data
R9911 T12708 T12709 compound protein,data
R9912 T12709 T12706 pobj data,with
R9913 T12710 T12711 punct (,Figure
R9914 T12711 T12709 appos Figure,data
R9915 T12712 T12711 nummod 1A,Figure
R9916 T12713 T12711 punct ),Figure
R9917 T12714 T12692 punct .,had
R9918 T12715 T12718 advmod However,induced
R9919 T12716 T12718 punct ",",induced
R9920 T12717 T12718 nsubj IL-12,induced
R9921 T12718 T12718 ROOT induced,induced
R9922 T12719 T12721 det a,amount
R9923 T12720 T12721 amod high,amount
R9924 T12721 T12718 dobj amount,induced
R9925 T12722 T12721 prep of,amount
R9926 T12723 T12724 amod Il10,transcription
R9927 T12724 T12722 pobj transcription,of
R9928 T12725 T12727 advmod as,as
R9929 T12726 T12727 advmod well,as
R9930 T12727 T12724 cc as,transcription
R9931 T12728 T12729 compound Ifnγ,expression
R9932 T12729 T12721 appos expression,amount
R9933 T12730 T12729 prep with,expression
R9934 T12731 T12733 amod increased,doses
R9935 T12732 T12733 compound antigen,doses
R9936 T12733 T12730 pobj doses,with
R9937 T12734 T12736 punct (,6A
R9938 T12735 T12736 compound Figure,6A
R9939 T12736 T12733 appos 6A,doses
R9940 T12737 T12733 punct ),doses
R9941 T12738 T12718 punct ",",induced
R9942 T12739 T12718 advmod again,induced
R9943 T12740 T12718 prep in,induced
R9944 T12741 T12740 pobj keeping,in
R9945 T12742 T12741 prep with,keeping
R9946 T12743 T12745 det the,data
R9947 T12744 T12745 compound protein,data
R9948 T12745 T12742 pobj data,with
R9949 T12746 T12747 punct (,Figure
R9950 T12747 T12745 appos Figure,data
R9951 T12748 T12747 nummod 1A,Figure
R9952 T12749 T12747 punct ),Figure
R9953 T12750 T12718 punct .,induced
R9954 T12751 T12754 nummod CD4,cells
R9955 T12752 T12754 nummod +,cells
R9956 T12753 T12754 compound T,cells
R9957 T12754 T12763 nsubj cells,express
R9958 T12755 T12754 acl differentiated,cells
R9959 T12756 T12755 prep with,differentiated
R9960 T12757 T12758 amod increasing,doses
R9961 T12758 T12756 pobj doses,with
R9962 T12759 T12758 prep of,doses
R9963 T12760 T12759 pobj antigen,of
R9964 T12761 T12763 aux did,express
R9965 T12762 T12763 neg not,express
R9966 T12763 T12763 ROOT express,express
R9967 T12764 T12765 amod high,amounts
R9968 T12765 T12763 dobj amounts,express
R9969 T12766 T12765 prep of,amounts
R9970 T12767 T12766 pobj Tbx-21,of
R9971 T12768 T12767 punct (,Tbx-21
R9972 T12769 T12767 appos T-bet,Tbx-21
R9973 T12770 T12767 punct ),Tbx-21
R9974 T12771 T12763 npadvmod mRNA,express
R9975 T12772 T12763 punct ",",express
R9976 T12773 T12776 mark unless,cocultured
R9977 T12774 T12776 nsubjpass they,cocultured
R9978 T12775 T12776 auxpass were,cocultured
R9979 T12776 T12763 advcl cocultured,express
R9980 T12777 T12776 prep with,cocultured
R9981 T12778 T12777 pobj IL-12,with
R9982 T12779 T12781 punct (,6B
R9983 T12780 T12781 compound Figure,6B
R9984 T12781 T12778 appos 6B,IL-12
R9985 T12782 T12778 punct ),IL-12
R9986 T12783 T12763 punct .,express
R9987 T12784 T12795 prep In,observed
R9988 T12785 T12784 pobj contrast,In
R9989 T12786 T12795 punct ",",observed
R9990 T12787 T12788 amod high,amounts
R9991 T12788 T12795 nsubjpass amounts,observed
R9992 T12789 T12788 prep of,amounts
R9993 T12790 T12792 compound GATA-3,expression
R9994 T12791 T12792 compound mRNA,expression
R9995 T12792 T12789 pobj expression,of
R9996 T12793 T12795 auxpass were,observed
R9997 T12794 T12795 advmod only,observed
R9998 T12795 T12795 ROOT observed,observed
R9999 T12796 T12795 prep under,observed
R10000 T12797 T12800 compound Th2,conditions
R10001 T12798 T12799 compound cell,differentiation
R10002 T12799 T12800 compound differentiation,conditions
R10003 T12800 T12796 pobj conditions,under
R10004 T12801 T12800 punct (,conditions
R10005 T12802 T12803 amod low-dose,antigen
R10006 T12803 T12800 appos antigen,conditions
R10007 T12804 T12800 punct ),conditions
R10008 T12805 T12807 punct (,6B
R10009 T12806 T12807 compound Figure,6B
R10010 T12807 T12800 appos 6B,conditions
R10011 T12808 T12795 punct ),observed
R10012 T12809 T12795 punct ",",observed
R10013 T12810 T12795 cc and,observed
R10014 T12811 T12812 det this,expression
R10015 T12812 T12815 nsubjpass expression,downregulated
R10016 T12813 T12815 auxpass was,downregulated
R10017 T12814 T12815 advmod markedly,downregulated
R10018 T12815 T12795 conj downregulated,observed
R10019 T12816 T12815 agent by,downregulated
R10020 T12817 T12820 det both,dose
R10021 T12818 T12820 amod increasing,dose
R10022 T12819 T12820 compound antigen,dose
R10023 T12820 T12816 pobj dose,by
R10024 T12821 T12820 cc and,dose
R10025 T12822 T12820 conj coculture,dose
R10026 T12823 T12820 prep in,dose
R10027 T12824 T12823 pobj IL-12,in
R10028 T12825 T12827 punct (,6B
R10029 T12826 T12827 compound Figure,6B
R10030 T12827 T12824 appos 6B,IL-12
R10031 T12828 T12824 punct ),IL-12
R10032 T12829 T12815 punct .,downregulated
R10033 T12830 T12838 nsubj Differentiation,led
R10034 T12831 T12830 prep of,Differentiation
R10035 T12832 T12833 compound T,cells
R10036 T12833 T12831 pobj cells,of
R10037 T12834 T12830 prep under,Differentiation
R10038 T12835 T12837 amod low,dose
R10039 T12836 T12837 compound antigen,dose
R10040 T12837 T12834 pobj dose,under
R10041 T12838 T12838 ROOT led,led
R10042 T12839 T12838 prep to,led
R10043 T12840 T12839 pobj expression,to
R10044 T12841 T12840 prep of,expression
R10045 T12842 T12841 pobj c-maf,of
R10046 T12843 T12838 punct ",",led
R10047 T12844 T12838 prep in,led
R10048 T12845 T12844 pobj keeping,in
R10049 T12846 T12845 prep with,keeping
R10050 T12847 T12850 det the,profile
R10051 T12848 T12850 compound Th2,profile
R10052 T12849 T12850 compound cell,profile
R10053 T12850 T12846 pobj profile,with
R10054 T12851 T12850 punct (,profile
R10055 T12852 T12854 compound Ho,al.
R10056 T12853 T12854 nmod et,al.
R10057 T12854 T12850 appos al.,profile
R10058 T12855 T12854 punct ",",al.
R10059 T12856 T12854 appos 1996,al.
R10060 T12857 T12854 punct ),al.
R10061 T12858 T12850 punct ",",profile
R10062 T12859 T12860 nsubj which,was
R10063 T12860 T12863 auxpass was,abrogated
R10064 T12861 T12862 advmod almost,completely
R10065 T12862 T12863 advmod completely,abrogated
R10066 T12863 T12838 advcl abrogated,led
R10067 T12864 T12863 prep by,abrogated
R10068 T12865 T12864 pcomp increasing,by
R10069 T12866 T12865 dobj doses,increasing
R10070 T12867 T12866 prep of,doses
R10071 T12868 T12867 pobj antigen,of
R10072 T12869 T12871 punct (,6B
R10073 T12870 T12871 compound Figure,6B
R10074 T12871 T12868 appos 6B,antigen
R10075 T12872 T12871 punct ),6B
R10076 T12873 T12838 punct .,led
R10077 T12874 T12877 advmod Interestingly,sustained
R10078 T12875 T12877 punct ",",sustained
R10079 T12876 T12877 nsubj IL-12,sustained
R10080 T12877 T12877 ROOT sustained,sustained
R10081 T12878 T12880 det the,expression
R10082 T12879 T12880 amod high,expression
R10083 T12880 T12877 dobj expression,sustained
R10084 T12881 T12880 prep of,expression
R10085 T12882 T12883 compound c-Maf,mRNA
R10086 T12883 T12881 pobj mRNA,of
R10087 T12884 T12885 advmod even,at
R10088 T12885 T12877 prep at,sustained
R10089 T12886 T12889 det the,dose
R10090 T12887 T12889 amod highest,dose
R10091 T12888 T12889 compound antigen,dose
R10092 T12889 T12885 pobj dose,at
R10093 T12890 T12892 punct (,6B
R10094 T12891 T12892 compound Figure,6B
R10095 T12892 T12889 appos 6B,dose
R10096 T12893 T12892 punct ),6B
R10097 T12894 T12877 punct .,sustained
R10098 T12895 T12902 advmod Moreover,required
R10099 T12896 T12902 punct ",",required
R10100 T12897 T12898 amod IL-12,maintenance
R10101 T12898 T12902 nsubj maintenance,required
R10102 T12899 T12898 prep of,maintenance
R10103 T12900 T12901 amod c-maf,expression
R10104 T12901 T12899 pobj expression,of
R10105 T12902 T12902 ROOT required,required
R10106 T12903 T12904 nummod STAT4,activation
R10107 T12904 T12902 dobj activation,required
R10108 T12905 T12906 punct (,data
R10109 T12906 T12904 appos data,activation
R10110 T12907 T12908 neg not,shown
R10111 T12908 T12906 acl shown,data
R10112 T12909 T12906 punct ),data
R10113 T12910 T12902 punct .,required
R10114 T12911 T12931 prep In,were
R10115 T12912 T12913 amod Th17,cells
R10116 T12913 T12911 pobj cells,In
R10117 T12914 T12915 nsubj that,expressed
R10118 T12915 T12911 relcl expressed,In
R10119 T12916 T12915 dobj IL-17a,expressed
R10120 T12917 T12919 advmod as,as
R10121 T12918 T12919 advmod well,as
R10122 T12919 T12916 cc as,IL-17a
R10123 T12920 T12921 compound IL-10,mRNA
R10124 T12921 T12931 nsubj mRNA,were
R10125 T12922 T12924 punct (,6C
R10126 T12923 T12924 compound Figure,6C
R10127 T12924 T12921 appos 6C,mRNA
R10128 T12925 T12924 punct ),6C
R10129 T12926 T12924 punct ",",6C
R10130 T12927 T12924 conj T-bet,6C
R10131 T12928 T12927 cc and,T-bet
R10132 T12929 T12930 compound GATA-3,mRNA
R10133 T12930 T12927 conj mRNA,T-bet
R10134 T12931 T12931 ROOT were,were
R10135 T12932 T12934 amod undetectable,data
R10136 T12933 T12934 punct (,data
R10137 T12934 T12931 attr data,were
R10138 T12935 T12936 neg not,shown
R10139 T12936 T12934 acl shown,data
R10140 T12937 T12934 punct ),data
R10141 T12938 T12931 punct ",",were
R10142 T12939 T12943 mark whereas,was
R10143 T12940 T12943 nsubj that,was
R10144 T12941 T12940 prep of,that
R10145 T12942 T12941 pobj ROR-γt,of
R10146 T12943 T12931 advcl was,were
R10147 T12944 T12943 acomp high,was
R10148 T12945 T12947 punct (,6C
R10149 T12946 T12947 nmod Figure,6C
R10150 T12947 T12943 npadvmod 6C,was
R10151 T12948 T12947 punct ),6C
R10152 T12949 T12952 punct (,al.
R10153 T12950 T12952 compound Ivanov,al.
R10154 T12951 T12952 nmod et,al.
R10155 T12952 T12931 dep al.,were
R10156 T12953 T12952 punct ",",al.
R10157 T12954 T12952 npadvmod 2007,al.
R10158 T12955 T12952 punct ),al.
R10159 T12956 T12931 punct .,were
R10160 T12957 T12958 nummod Th17,cells
R10161 T12958 T12960 nsubj cells,expressed
R10162 T12959 T12960 advmod also,expressed
R10163 T12960 T12960 ROOT expressed,expressed
R10164 T12961 T12962 amod high,amounts
R10165 T12962 T12960 dobj amounts,expressed
R10166 T12963 T12962 prep of,amounts
R10167 T12964 T12963 pobj c-maf,of
R10168 T12965 T12967 punct (,6C
R10169 T12966 T12967 compound Figure,6C
R10170 T12967 T12964 appos 6C,c-maf
R10171 T12968 T12964 punct ),c-maf
R10172 T12969 T12960 punct ",",expressed
R10173 T12970 T12960 advcl confirming,expressed
R10174 T12971 T12973 det a,report
R10175 T12972 T12973 amod recent,report
R10176 T12973 T12970 dobj report,confirming
R10177 T12974 T12977 punct (,al.
R10178 T12975 T12977 nmod Bauquet,al.
R10179 T12976 T12977 nmod et,al.
R10180 T12977 T12973 appos al.,report
R10181 T12978 T12977 punct ",",al.
R10182 T12979 T12977 npadvmod 2009,al.
R10183 T12980 T12977 punct ),al.
R10184 T12981 T12960 punct .,expressed
R10185 T12982 T12985 nsubjpass c-Maf,expressed
R10186 T12983 T12985 auxpass is,expressed
R10187 T12984 T12985 advmod therefore,expressed
R10188 T12985 T12985 ROOT expressed,expressed
R10189 T12986 T12985 prep in,expressed
R10190 T12987 T12991 det all,populations
R10191 T12988 T12991 amod IL-10-expressing,populations
R10192 T12989 T12991 compound T,populations
R10193 T12990 T12991 compound cell,populations
R10194 T12991 T12986 pobj populations,in
R10195 T12992 T12991 acl tested,populations
R10196 T12993 T12995 punct (,6B
R10197 T12994 T12995 compound Figures,6B
R10198 T12995 T12992 oprd 6B,tested
R10199 T12996 T12995 cc and,6B
R10200 T12997 T12995 conj 6C,6B
R10201 T12998 T12997 punct ),6C
R10202 T12999 T12985 cc and,expressed
R10203 T13000 T13002 aux may,be
R10204 T13001 T13002 neg not,be
R10205 T13002 T12985 conj be,expressed
R10206 T13003 T13008 advmod just,factor
R10207 T13004 T13008 det a,factor
R10208 T13005 T13008 amod Th2,factor
R10209 T13006 T13008 amod cell-specific,factor
R10210 T13007 T13008 compound transcription,factor
R10211 T13008 T13002 attr factor,be
R10212 T13009 T13011 mark as,thought
R10213 T13010 T13011 advmod originally,thought
R10214 T13011 T13002 advcl thought,be
R10215 T13012 T13015 punct (,al.
R10216 T13013 T13015 compound Ho,al.
R10217 T13014 T13015 nmod et,al.
R10218 T13015 T13002 advmod al.,be
R10219 T13016 T13015 punct ",",al.
R10220 T13017 T13015 npadvmod 1996,al.
R10221 T13018 T13015 punct ),al.
R10222 T13019 T13002 punct .,be
R10223 T13020 T13021 nsubj We,showed
R10224 T13021 T13021 ROOT showed,showed
R10225 T13022 T13021 advmod also,showed
R10226 T13023 T13031 mark that,inhibited
R10227 T13024 T13031 prep like,inhibited
R10228 T13025 T13026 amod Il10,expression
R10229 T13026 T13024 pobj expression,like
R10230 T13027 T13031 punct ",",inhibited
R10231 T13028 T13029 amod c-maf,expression
R10232 T13029 T13031 nsubjpass expression,inhibited
R10233 T13030 T13031 auxpass was,inhibited
R10234 T13031 T13021 ccomp inhibited,showed
R10235 T13032 T13031 prep in,inhibited
R10236 T13033 T13032 pobj Th1,in
R10237 T13034 T13033 cc and,Th1
R10238 T13035 T13033 conj Th17,Th1
R10239 T13036 T13031 dobj cells,inhibited
R10240 T13037 T13036 prep in,cells
R10241 T13038 T13039 det the,presence
R10242 T13039 T13037 pobj presence,in
R10243 T13040 T13039 prep of,presence
R10244 T13041 T13042 det the,MEK1
R10245 T13042 T13040 pobj MEK1,of
R10246 T13043 T13042 cc and,MEK1
R10247 T13044 T13045 compound MEK2,inhibitor
R10248 T13045 T13036 conj inhibitor,cells
R10249 T13046 T13047 punct (,PD184352
R10250 T13047 T13045 appos PD184352,inhibitor
R10251 T13048 T13031 punct ),inhibited
R10252 T13049 T13031 punct ",",inhibited
R10253 T13050 T13055 mark whereas,was
R10254 T13051 T13054 poss T-bet,expression
R10255 T13052 T13051 cc and,T-bet
R10256 T13053 T13054 compound RORγt,expression
R10257 T13054 T13055 nsubj expression,was
R10258 T13055 T13031 advcl was,inhibited
R10259 T13056 T13057 advmod hardly,affected
R12582 T15871 T15872 compound IL-10,expression
R12583 T15872 T15882 nsubj expression,reflects
R12584 T15873 T15872 prep by,expression
R12585 T15874 T15873 pobj cells,by
R12586 T15875 T15874 prep of,cells
R12587 T15876 T15881 det the,systems
R12588 T15877 T15881 amod innate,systems
R12589 T15878 T15877 cc and,innate
R12590 T15879 T15877 conj adaptive,innate
R12591 T15880 T15881 amod immune,systems
R12592 T15881 T15875 pobj systems,of
R12593 T15882 T15882 ROOT reflects,reflects
R12594 T15883 T15884 det the,importance
R12595 T15884 T15882 dobj importance,reflects
R12596 T15885 T15884 prep of,importance
R12597 T15886 T15887 det this,cytokine
R12598 T15887 T15885 pobj cytokine,of
R12599 T15888 T15884 prep in,importance
R12600 T15889 T15891 det the,regulation
R12601 T15890 T15891 amod tight,regulation
R12602 T15891 T15888 pobj regulation,in
R12603 T15892 T15891 prep of,regulation
R12604 T15893 T15895 det the,response
R12605 T15894 T15895 amod immune,response
R12606 T15895 T15892 pobj response,of
R12607 T15896 T15882 punct ",",reflects
R12608 T15897 T15898 aux to,minimize
R12609 T15898 T15882 advcl minimize,reflects
R12610 T15899 T15898 dobj pathology,minimize
R12611 T15900 T15898 prep during,minimize
R12612 T15901 T15900 pobj infection,during
R12613 T15902 T15882 punct .,reflects
R12614 T15903 T15904 compound IL-10,expression
R12615 T15904 T15910 nsubjpass expression,reported
R12616 T15905 T15904 prep by,expression
R12617 T15906 T15907 amod Th1,cells
R12618 T15907 T15905 pobj cells,by
R12619 T15908 T15910 aux has,reported
R12620 T15909 T15910 auxpass been,reported
R12621 T15910 T15910 ROOT reported,reported
R12622 T15911 T15912 aux to,regulate
R12623 T15912 T15910 xcomp regulate,reported
R12624 T15913 T15915 det the,response
R12625 T15914 T15915 amod immune,response
R12626 T15915 T15912 dobj response,regulate
R12627 T15916 T15915 prep in,response
R12628 T15917 T15916 pobj leishmaniasis,in
R12629 T15918 T15917 cc and,leishmaniasis
R12630 T15919 T15917 conj toxoplasmosis,leishmaniasis
R12631 T15920 T15910 punct .,reported
R12632 T15921 T15930 advmod However,produced
R12633 T15922 T15930 punct ",",produced
R12634 T15923 T15930 prep in,produced
R12635 T15924 T15925 amod many,situations
R12636 T15925 T15923 pobj situations,in
R12637 T15926 T15930 punct ",",produced
R12638 T15927 T15930 nsubjpass IL-10,produced
R12639 T15928 T15930 auxpass is,produced
R12640 T15929 T15930 neg not,produced
R12641 T15930 T15930 ROOT produced,produced
R12642 T15931 T15930 agent by,produced
R12643 T15932 T15933 amod Th1,cells
R12644 T15933 T15931 pobj cells,by
R12645 T15934 T15930 prep in,produced
R12646 T15935 T15934 pobj response,in
R12647 T15936 T15935 prep to,response
R12648 T15937 T15938 amod antigenic,stimulation
R12649 T15938 T15936 pobj stimulation,to
R12650 T15939 T15930 punct .,produced
R12651 T15940 T15941 poss Our,goal
R12652 T15941 T15942 nsubj goal,was
R12653 T15942 T15942 ROOT was,was
R12654 T15943 T15944 aux to,address
R12655 T15944 T15942 xcomp address,was
R12656 T15945 T15947 det the,signals
R12657 T15946 T15947 amod molecular,signals
R12658 T15947 T15944 dobj signals,address
R12659 T15948 T15949 nsubj that,determine
R12660 T15949 T15947 relcl determine,signals
R12661 T15950 T15953 mark whether,develop
R12662 T15951 T15952 amod Th1,cells
R12663 T15952 T15953 nsubj cells,develop
R12664 T15953 T15949 ccomp develop,determine
R12665 T15954 T15955 aux to,produce
R12666 T15955 T15953 xcomp produce,develop
R12667 T15956 T15955 dobj IL-10,produce
R12668 T15957 T15958 punct (,Trinchieri
R12669 T15958 T15956 appos Trinchieri,IL-10
R12670 T15959 T15958 punct ",",Trinchieri
R12671 T15960 T15958 npadvmod 2007,Trinchieri
R12672 T15961 T15958 punct ),Trinchieri
R12673 T15962 T15942 punct .,was
R12674 T15963 T15966 advmod Here,showed
R12675 T15964 T15966 punct ",",showed
R12676 T15965 T15966 nsubj we,showed
R12677 T15966 T15966 ROOT showed,showed
R12678 T15967 T15981 mark that,produce
R12679 T15968 T15969 amod Th1,cells
R12680 T15969 T15981 nsubj cells,produce
R12681 T15970 T15969 acl required,cells
R12682 T15971 T15970 dobj high-antigen-dose-induced,required
R12683 T15972 T15971 nummod ERK1,high-antigen-dose-induced
R12684 T15973 T15972 cc and,ERK1
R12685 T15974 T15972 conj ERK2,ERK1
R12686 T15975 T15979 nmod phosphorylation,activation
R12687 T15976 T15975 cc and,phosphorylation
R12688 T15977 T15975 conj IL-12-induced,phosphorylation
R12689 T15978 T15979 compound STAT-4,activation
R12690 T15979 T15969 conj activation,cells
R12691 T15980 T15981 aux to,produce
R12692 T15981 T15966 ccomp produce,showed
R12693 T15982 T15981 dobj IL-10,produce
R12694 T15983 T15966 punct .,showed
R12695 T15984 T15985 poss Our,findings
R12696 T15985 T15985 ROOT findings,findings
R12697 T15986 T15991 mark that,was
R12698 T15987 T15990 amod ERK1,activation
R12699 T15988 T15987 cc and,ERK1
R12700 T15989 T15987 conj ERK2,ERK1
R12701 T15990 T15991 nsubj activation,was
R12702 T15991 T15985 acl was,findings
R12703 T15992 T15994 det a,pathway
R12704 T15993 T15994 amod common,pathway
R12705 T15994 T15991 attr pathway,was
R12706 T15995 T15994 acl required,pathway
R12707 T15996 T15995 prep for,required
R12708 T15997 T15998 det the,production
R12709 T15998 T15996 pobj production,for
R12710 T15999 T15998 prep of,production
R12711 T16000 T15999 pobj IL-10,of
R12712 T16001 T15998 prep by,production
R12713 T16002 T16001 pobj Th1,by
R12714 T16003 T16002 punct ",",Th1
R12715 T16004 T16002 conj Th2,Th1
R12716 T16005 T16004 punct ",",Th2
R12717 T16006 T16004 cc and,Th2
R12718 T16007 T16009 compound Th17,subsets
R12719 T16008 T16009 compound cell,subsets
R12720 T16009 T16004 conj subsets,Th2
R12721 T16010 T16009 punct ",",subsets
R12722 T16011 T16012 nsubj which,differentiate
R12723 T16012 T16009 relcl differentiate,subsets
R12724 T16013 T16012 prep along,differentiate
R12725 T16014 T16015 amod distinct,pathways
R12726 T16015 T16013 pobj pathways,along
R12727 T16016 T16015 punct ",",pathways
R12728 T16017 T16020 amod such,provides
R12729 T16018 T16020 mark that,provides
R12730 T16019 T16020 nsubj IL-10,provides
R12731 T16020 T15985 advcl provides,findings
R12732 T16021 T16025 det a,loop
R12733 T16022 T16023 advmod highly,regulated
R12734 T16023 T16025 amod regulated,loop
R12735 T16024 T16025 compound feedback,loop
R12736 T16025 T16020 dobj loop,provides
R12737 T16026 T16027 aux to,avoid
R12738 T16027 T16020 advcl avoid,provides
R12739 T16028 T16029 det the,extremes
R12740 T16029 T16027 dobj extremes,avoid
R12741 T16030 T16029 prep of,extremes
R12742 T16031 T16032 amod excessive,inflammation
R12743 T16032 T16030 pobj inflammation,of
R12744 T16033 T16032 cc or,inflammation
R12745 T16034 T16035 amod chronic,infections
R12747 T16036 T16020 cc and,provides
R12748 T16037 T16038 advmod also,allow
R12749 T16038 T16020 conj allow,provides
R12750 T16039 T16041 det a,response
R12751 T16040 T16041 amod protective,response
R12752 T16041 T16038 dobj response,allow
R12753 T16042 T16041 prep to,response
R12754 T16043 T16044 amod diverse,pathogens
R12755 T16044 T16042 pobj pathogens,to
R12756 T16045 T15985 punct .,findings
R12757 T16046 T16077 prep In,lead
R12758 T16047 T16051 amod certain,infections
R12759 T16048 T16051 amod viral,infections
R12760 T16049 T16048 cc or,viral
R12761 T16050 T16048 conj parasitic,viral
R12762 T16051 T16046 pobj infections,In
R12763 T16052 T16055 punct (,al.
R12764 T16053 T16055 compound Anderson,al.
R12765 T16054 T16055 nmod et,al.
R12766 T16055 T16077 ccomp al.,lead
R12767 T16056 T16055 punct ",",al.
R12768 T16057 T16055 npadvmod 2007,al.
R12769 T16058 T16077 punct ;,lead
R12770 T16059 T16061 compound Brooks,al.
R12771 T16060 T16061 compound et,al.
R12772 T16061 T16077 nsubj al.,lead
R12773 T16062 T16061 punct ",",al.
R12774 T16063 T16061 npadvmod 2006,al.
R12775 T16064 T16077 punct ;,lead
R12776 T16065 T16067 compound Ejrnaes,al.
R12777 T16066 T16067 compound et,al.
R12778 T16067 T16077 nsubj al.,lead
R12779 T16068 T16067 punct ",",al.
R12780 T16069 T16067 npadvmod 2006,al.
R12781 T16070 T16067 punct ),al.
R12782 T16071 T16077 punct ",",lead
R12783 T16072 T16073 amod high,amounts
R12784 T16073 T16077 nsubj amounts,lead
R12785 T16074 T16073 prep of,amounts
R12786 T16075 T16074 pobj stimulation,of
R12787 T16076 T16077 aux may,lead
R12788 T16077 T16077 ROOT lead,lead
R12789 T16078 T16077 prep to,lead
R12790 T16079 T16082 det the,infection
R12791 T16080 T16082 amod chronic,infection
R12792 T16081 T16082 amod nonhealing,infection
R12793 T16082 T16078 pobj infection,to
R12794 T16083 T16082 acl shown,infection
R12795 T16084 T16086 aux to,regulated
R12796 T16085 T16086 auxpass be,regulated
R12797 T16086 T16083 xcomp regulated,shown
R12798 T16087 T16086 agent by,regulated
R12799 T16088 T16087 pobj IL-10,by
R12800 T16089 T16077 punct .,lead
R12801 T16090 T16104 prep During,migrate
R12802 T16091 T16092 det the,course
R12803 T16092 T16090 pobj course,During
R12804 T16093 T16092 prep of,course
R12805 T16094 T16093 pobj infection,of
R12806 T16095 T16104 punct ",",migrate
R12807 T16096 T16104 prep after,migrate
R12808 T16097 T16098 amod initial,triggering
R12809 T16098 T16096 pcomp triggering,after
R12810 T16099 T16098 prep with,triggering
R12811 T16100 T16099 pobj antigen,with
R12812 T16101 T16104 punct ",",migrate
R12813 T16102 T16103 compound T,cells
R12814 T16103 T16104 nsubj cells,migrate
R12815 T16104 T16104 ROOT migrate,migrate
R12816 T16105 T16104 prep to,migrate
R12817 T16106 T16107 det the,tissue
R12818 T16107 T16108 nsubj tissue,encountering
R12819 T16108 T16105 pcomp encountering,to
R12820 T16109 T16110 amod high,doses
R12821 T16110 T16108 dobj doses,encountering
R12822 T16111 T16110 prep of,doses
R12823 T16112 T16111 pobj antigen,of
R12824 T16113 T16110 cc and,doses
R12825 T16114 T16110 conj factors,doses
R12826 T16115 T16114 acl produced,factors
R12827 T16116 T16115 agent by,produced
R12828 T16117 T16120 det the,response
R12829 T16118 T16120 amod innate,response
R12830 T16119 T16120 amod immune,response
R12831 T16120 T16116 pobj response,by
R12832 T16121 T16104 punct .,migrate
R12833 T16122 T16127 prep Under,speculate
R12834 T16123 T16124 det these,conditions
R12835 T16124 T16122 pobj conditions,Under
R12836 T16125 T16127 punct ",",speculate
R12837 T16126 T16127 nsubj we,speculate
R12838 T16127 T16127 ROOT speculate,speculate
R12839 T16128 T16133 mark that,induced
R12840 T16129 T16130 amod Th1,cells
R12841 T16130 T16133 nsubjpass cells,induced
R12842 T16131 T16133 aux will,induced
R12843 T16132 T16133 auxpass be,induced
R12844 T16133 T16127 ccomp induced,speculate
R12845 T16134 T16135 aux to,express
R12846 T16135 T16133 xcomp express,induced
R12847 T16136 T16137 amod high,amounts
R12848 T16137 T16135 dobj amounts,express
R12849 T16138 T16137 prep of,amounts
R12850 T16139 T16138 pobj IL-10,of
R12851 T16140 T16133 punct ",",induced
R12852 T16141 T16133 prep in,induced
R12853 T16142 T16141 pobj keeping,in
R12854 T16143 T16142 prep with,keeping
R12855 T16144 T16143 pobj reports,with
R12856 T16145 T16150 mark that,found
R12857 T16146 T16148 amod IL-10-producing,cells
R12858 T16147 T16148 amod Th1,cells
R12859 T16148 T16150 nsubjpass cells,found
R12860 T16149 T16150 auxpass were,found
R12861 T16150 T16144 acl found,reports
R12862 T16151 T16150 prep in,found
R12863 T16152 T16154 nummod CD4,clones
R12864 T16153 T16154 nummod +,clones
R12865 T16154 T16151 pobj clones,in
R12866 T16155 T16154 acl isolated,clones
R12867 T16156 T16155 prep from,isolated
R12868 T16157 T16156 pobj BAL,from
R12869 T16158 T16155 cc but,isolated
R12870 T16159 T16160 neg not,blood
R12871 T16160 T16154 appos blood,clones
R12872 T16161 T16160 prep of,blood
R12873 T16162 T16163 compound TB,patients
R12874 T16163 T16161 pobj patients,of
R12875 T16164 T16163 punct (,patients
R12876 T16165 T16167 compound Gerosa,al.
R12877 T16166 T16167 nmod et,al.
R12878 T16167 T16163 appos al.,patients
R12879 T16168 T16167 punct ",",al.
R12880 T16169 T16167 npadvmod 1999,al.
R12881 T16170 T16163 punct ),patients
R12882 T16171 T16127 punct .,speculate
R12883 T16172 T16193 advmod Similarly,found
R12884 T16173 T16193 punct ",",found
R12885 T16174 T16176 det the,response
R12886 T16175 T16176 amod immune,response
R12887 T16176 T16193 nsubjpass response,found
R12888 T16177 T16176 prep to,response
R12889 T16178 T16180 det a,isolate
R12890 T16179 T16180 amod clinical,isolate
R12891 T16180 T16177 pobj isolate,to
R12892 T16181 T16180 prep of,isolate
R12893 T16182 T16183 compound L.,major
R12894 T16183 T16181 pobj major,of
R12895 T16184 T16183 punct ",",major
R12896 T16185 T16186 nsubj which,produces
R12897 T16186 T16183 relcl produces,major
R12898 T16187 T16188 advmod heavily,infected
R12899 T16188 T16190 amod infected,lesions
R12900 T16189 T16190 amod nonhealing,lesions
R12901 T16190 T16186 dobj lesions,produces
R12902 T16191 T16193 punct ",",found
R12903 T16192 T16193 auxpass was,found
R12904 T16193 T16193 ROOT found,found
R12905 T16194 T16196 aux to,regulated
R12906 T16195 T16196 auxpass be,regulated
R12907 T16196 T16193 xcomp regulated,found
R12908 T16197 T16196 agent by,regulated
R12909 T16198 T16197 pobj IL-10,by
R12910 T16199 T16198 acl derived,IL-10
R12911 T16200 T16199 prep from,derived
R12912 T16201 T16203 compound Foxp3,Th1
R12913 T16202 T16203 compound −,Th1
R12914 T16203 T16204 compound Th1,cells
R12915 T16204 T16200 pobj cells,from
R12916 T16205 T16206 nsubj that,coproduce
R12917 T16206 T16204 relcl coproduce,cells
R12918 T16207 T16206 dobj IL-10,coproduce
R12919 T16208 T16207 cc and,IL-10
R12920 T16209 T16207 conj IFN-γ,IL-10
R12921 T16210 T16209 punct (,IFN-γ
R12922 T16235 T16236 compound Th1,cells
R12923 T16211 T16213 compound Anderson,al.
R12924 T16236 T16232 pobj cells,by
R12925 T16212 T16213 nmod et,al.
R12926 T16237 T16240 punct (,al.
R12927 T16238 T16240 amod Jankovic,al.
R12928 T16213 T16209 conj al.,IFN-γ
R12929 T16239 T16240 nmod et,al.
R12930 T16240 T16236 appos al.,cells
R12931 T16214 T16213 punct ",",al.
R12932 T16241 T16240 punct ",",al.
R12933 T16242 T16240 npadvmod 2007,al.
R12934 T16243 T16227 punct ),found
R12935 T16215 T16213 npadvmod 2007,al.
R12936 T16244 T16227 punct .,found
R12937 T16245 T16246 nsubj It,is
R12938 T16216 T16213 punct ),al.
R12939 T16246 T16246 ROOT is,is
R12940 T16247 T16246 acomp likely,is
R12941 T16248 T16255 mark that,evoked
R12942 T16249 T16250 amod IL-10,production
R12943 T16217 T16209 punct ",",IFN-γ
R12944 T16250 T16255 nsubjpass production,evoked
R12945 T16251 T16250 prep by,production
R12946 T16218 T16209 cc and,IFN-γ
R12947 T16252 T16253 amod Th1,cells
R12948 T16253 T16251 pobj cells,by
R12949 T16254 T16255 auxpass is,evoked
R12950 T16219 T16221 det the,response
R12951 T16255 T16246 ccomp evoked,is
R12952 T16256 T16255 prep under,evoked
R12953 T16257 T16256 pobj conditions,under
R12954 T16220 T16221 amod immune,response
R12955 T16258 T16257 prep of,conditions
R12956 T16259 T16260 amod high,inflammation
R12957 T16221 T16227 nsubjpass response,found
R12958 T16260 T16258 pobj inflammation,of
R12959 T16261 T16260 cc and,inflammation
R12960 T16262 T16263 amod antigenic,stimulation
R12961 T16222 T16221 prep during,response
R12962 T16263 T16260 conj stimulation,inflammation
R12963 T16223 T16224 compound T.,gondii
R12964 T16224 T16225 compound gondii,infection
R12965 T16225 T16222 pobj infection,during
R12966 T16264 T16255 punct ",",evoked
R12967 T16265 T16274 mark whereas,operate
R12968 T16266 T16270 amod regulatory,cells
R12969 T16267 T16270 nmod CD4,cells
R12970 T16226 T16227 auxpass was,found
R12971 T16268 T16270 nummod +,cells
R12972 T16269 T16270 compound T,cells
R12973 T16270 T16274 nsubj cells,operate
R12974 T16271 T16270 acl producing,cells
R12975 T16272 T16271 dobj IL-10,producing
R12976 T16273 T16274 aux may,operate
R12977 T16227 T16193 conj found,found
R12978 T16274 T16255 advcl operate,evoked
R12979 T16275 T16276 aux to,regulate
R12980 T16276 T16274 xcomp regulate,operate
R12981 T16228 T16231 advmod also,regulated
R12982 T16277 T16279 det the,response
R12983 T16278 T16279 amod immune,response
R12984 T16279 T16276 dobj response,regulate
R12985 T16280 T16276 prep under,regulate
R12986 T16229 T16231 aux to,regulated
R12987 T16281 T16280 pobj conditions,under
R12988 T16282 T16288 prep in,controlled
R12989 T16230 T16231 auxpass be,regulated
R12990 T16283 T16282 pobj which,in
R12991 T16284 T16285 det the,pathogen
R12992 T16231 T16227 advcl regulated,found
R12993 T16285 T16288 nsubjpass pathogen,controlled
R12994 T16232 T16231 agent by,regulated
R12995 T16286 T16288 auxpass is,controlled
R12996 T16287 T16288 advmod clinically,controlled
R12997 T16233 T16235 compound Foxp3,Th1
R12998 T16288 T16281 relcl controlled,conditions
R12999 T16289 T16281 punct ",",conditions
R13000 T16290 T16291 amod such,as
R13001 T16291 T16281 prep as,conditions
R13002 T16234 T16235 compound −,Th1
R13003 T16292 T16291 prep in,as
R13004 T16332 T16331 prep into,differentiate
R13005 T16293 T16292 pobj infection,in
R13006 T16294 T16293 prep with,infection
R13007 T16333 T16336 amod canonical,cells
R13008 T16295 T16296 compound L.,major
R13009 T16296 T16294 pobj major,with
R13010 T16297 T16299 punct (,strain
R13011 T16298 T16299 compound Friedlin,strain
R13012 T16299 T16296 appos strain,major
R13013 T16300 T16246 punct ),is
R13014 T16334 T16336 amod Th1,cells
R13015 T16301 T16304 punct (,al.
R13016 T16302 T16304 nmod Belkaid,al.
R13017 T16303 T16304 nmod et,al.
R13018 T16335 T16336 compound effector,cells
R13019 T16304 T16310 compound al.,al.
R13020 T16305 T16304 punct ",",al.
R13021 T16306 T16304 npadvmod 2002,al.
R13022 T16307 T16304 punct ;,al.
R13023 T16308 T16310 compound Suffia,al.
R13024 T16309 T16310 compound et,al.
R13025 T16310 T16246 attr al.,is
R13026 T16336 T16332 pobj cells,into
R13027 T16311 T16310 punct ",",al.
R13028 T16312 T16310 npadvmod 2006,al.
R13029 T16313 T16310 punct ),al.
R13030 T16337 T16336 punct ",",cells
R13031 T16314 T16246 punct .,is
R13032 T16315 T16318 nsubj We,reported
R13033 T16316 T16318 advmod now,reported
R13034 T16338 T16351 nsubj which,lose
R13035 T16317 T16318 advmod also,reported
R13036 T16318 T16318 ROOT reported,reported
R13037 T16319 T16324 mark that,cultured
R13038 T16339 T16351 punct ",",lose
R13039 T16320 T16323 nummod CD4,cells
R13040 T16321 T16323 nummod +,cells
R13041 T16322 T16323 compound T,cells
R13042 T16340 T16351 prep in,lose
R13043 T16323 T16324 nsubj cells,cultured
R13044 T16324 T16318 ccomp cultured,reported
R13045 T16341 T16340 pobj addition,in
R13046 T16325 T16324 prep with,cultured
R13047 T16326 T16328 amod high,dose
R13048 T16327 T16328 compound antigen,dose
R13049 T16342 T16341 prep to,addition
R13050 T16328 T16325 pobj dose,with
R13051 T16329 T16328 cc and,dose
R13052 T16330 T16328 conj IL-12,dose
R13053 T16331 T16318 conj differentiate,reported
R13054 T16343 T16342 pcomp expressing,to
R13055 T16344 T16345 amod large,amounts
R13056 T16345 T16343 dobj amounts,expressing
R13057 T16346 T16345 prep of,amounts
R13058 T16347 T16346 pobj IFN-γ,of
R13059 T16429 T16427 pobj presence,in
R13060 T16348 T16347 cc and,IFN-γ
R13061 T16430 T16429 prep of,presence
R13062 T16431 T16432 amod high,doses
R13063 T16432 T16430 pobj doses,of
R13064 T16349 T16347 conj IL-10,IFN-γ
R13065 T16433 T16432 prep of,doses
R13066 T16434 T16435 compound OVA,protein
R13067 T16350 T16351 punct ",",lose
R13068 T16435 T16433 pobj protein,of
R13069 T16436 T16435 cc and,protein
R13070 T16351 T16336 relcl lose,cells
R13071 T16437 T16435 conj LPS,protein
R13072 T16438 T16420 punct .,showed
R13073 T16439 T16440 nsubj We,showed
R13074 T16440 T16440 ROOT showed,showed
R13075 T16441 T16440 advmod here,showed
R13076 T16442 T16452 mark that,was
R13077 T16352 T16354 poss their,expression
R13078 T16353 T16354 compound IL-2,expression
R13079 T16354 T16351 dobj expression,lose
R13080 T16443 T16444 det this,induction
R13081 T16355 T16356 mark as,described
R13082 T16444 T16452 nsubj induction,was
R13083 T16445 T16444 prep of,induction
R13084 T16446 T16445 pobj IL-10,of
R13085 T16356 T16351 advcl described,lose
R13086 T16447 T16446 prep in,IL-10
R13087 T16448 T16449 compound Th1,cells
R13088 T16357 T16356 advmod before,described
R13089 T16449 T16447 pobj cells,in
R13090 T16450 T16449 prep in,cells
R13091 T16358 T16356 prep in,described
R13092 T16451 T16450 pobj vivo,in
R13093 T16452 T16441 ccomp was,here
R13094 T16453 T16452 advmod markedly,was
R13095 T16359 T16362 amod certain,models
R13096 T16454 T16452 punct ",",was
R13097 T16455 T16459 cc but,reduced
R13098 T16360 T16362 amod chronic,models
R13099 T16456 T16457 neg not,totally
R13100 T16457 T16459 advmod totally,reduced
R13101 T16458 T16459 punct ",",reduced
R13102 T16361 T16362 compound infection,models
R13103 T16459 T16452 conj reduced,was
R13104 T16460 T16459 prep in,reduced
R13105 T16362 T16358 pobj models,in
R13106 T16461 T16463 amod STAT4-deficient,cells
R13107 T16462 T16463 compound T,cells
R13108 T16463 T16460 pobj cells,in
R13109 T16363 T16366 punct (,al.
R13110 T16464 T16465 mark as,observed
R13111 T16465 T16459 advcl observed,reduced
R13112 T16466 T16465 prep during,observed
R13113 T16364 T16366 nmod Sallusto,al.
R13114 T16467 T16468 compound T.,gondii
R13115 T16468 T16469 compound gondii,infection
R13116 T16365 T16366 nmod et,al.
R13117 T16469 T16466 pobj infection,during
R13118 T16470 T16473 punct (,al.
R13119 T16471 T16473 amod Jankovic,al.
R13120 T16366 T16362 appos al.,models
R13121 T16472 T16473 nmod et,al.
R13122 T16473 T16466 pobj al.,during
R13123 T16474 T16473 punct ",",al.
R13124 T16475 T16473 npadvmod 2002,al.
R13125 T16476 T16473 punct ),al.
R13126 T16477 T16440 punct .,showed
R13127 T16367 T16366 punct ",",al.
R13128 T16478 T16481 det A,activation
R13129 T16479 T16481 amod high,activation
R13130 T16480 T16481 amod antigenic,activation
R13131 T16368 T16366 npadvmod 2004,al.
R13132 T16481 T16504 nsubj activation,compensate
R13133 T16482 T16481 prep during,activation
R13134 T16369 T16362 punct ),models
R13135 T16483 T16484 compound T.,gondii
R13136 T16484 T16485 compound gondii,infection
R13137 T16485 T16482 pobj infection,during
R13138 T16370 T16318 punct .,reported
R13139 T16486 T16485 cc or,infection
R13140 T16487 T16488 amod high,antigen
R13141 T16488 T16489 compound antigen,doses
R13142 T16371 T16372 poss Our,demonstration
R13143 T16489 T16485 conj doses,infection
R13144 T16490 T16489 acl delivered,doses
R13145 T16491 T16490 prep in,delivered
R13146 T16372 T16383 nsubj demonstration,offers
R13147 T16492 T16493 det the,presence
R13148 T16373 T16378 mark that,accompanied
R13149 T16493 T16491 pobj presence,in
R13150 T16374 T16378 nsubjpass loss,accompanied
R13151 T16375 T16374 prep of,loss
R13152 T16494 T16493 prep of,presence
R13153 T16376 T16375 pobj IL-2,of
R13154 T16377 T16378 auxpass is,accompanied
R13155 T16495 T16494 pobj LPS,of
R13156 T16378 T16372 acl accompanied,demonstration
R13157 T16496 T16489 punct ",",doses
R13158 T16497 T16498 mark as,seen
R13159 T16379 T16378 agent by,accompanied
R13160 T16498 T16481 advcl seen,activation
R13161 T16499 T16498 prep in,seen
R13162 T16500 T16501 poss our,system
R13163 T16380 T16379 pobj production,by
R13164 T16501 T16499 pobj system,in
R13165 T16502 T16481 punct ",",activation
R13166 T16503 T16504 aux may,compensate
R13167 T16381 T16380 prep of,production
R13168 T16504 T16504 ROOT compensate,compensate
R13169 T16505 T16504 prep for,compensate
R13170 T16506 T16508 det an,requirement
R13171 T16382 T16383 nsubj IL-10,offers
R13172 T16507 T16508 amod absolute,requirement
R13173 T16508 T16505 pobj requirement,for
R13174 T16509 T16508 prep for,requirement
R13175 T16510 T16509 pobj IL-12,for
R13176 T16511 T16508 prep in,requirement
R13177 T16512 T16513 det the,induction
R13178 T16383 T16383 ROOT offers,offers
R13179 T16513 T16511 pobj induction,in
R13180 T16514 T16513 prep of,induction
R13181 T16515 T16514 pobj IL-10,of
R13182 T16384 T16386 amod potential,mechanisms
R13183 T16516 T16513 prep by,induction
R13184 T16517 T16518 amod Th1,cells
R13185 T16385 T16386 amod additional,mechanisms
R13186 T16518 T16516 pobj cells,by
R13187 T16519 T16504 punct .,compensate
R13188 T16520 T16535 prep In,allowed
R13189 T16386 T16383 dobj mechanisms,offers
R13190 T16521 T16524 poss our,system
R13191 T16522 T16524 nmod in,system
R13192 T16387 T16394 advmod whereby,dampened
R13193 T16523 T16524 amod vitro,system
R13194 T16524 T16520 pobj system,In
R13195 T16388 T16391 amod effector,responses
R13196 T16389 T16390 compound T,cell
R13197 T16525 T16526 punct ",",repeated
R13198 T16390 T16391 compound cell,responses
R13199 T16391 T16394 nsubjpass responses,dampened
R13200 T16392 T16394 aux may,dampened
R13201 T16526 T16527 amod repeated,stimulation
R13202 T16527 T16535 nsubj stimulation,allowed
R13203 T16393 T16394 auxpass be,dampened
R13204 T16528 T16527 prep of,stimulation
R13205 T16529 T16530 amod Th1,cells
R13206 T16530 T16528 pobj cells,of
R13207 T16394 T16386 relcl dampened,mechanisms
R13208 T16531 T16530 prep with,cells
R13209 T16532 T16534 amod high,doses
R13210 T16395 T16394 prep during,dampened
R13211 T16533 T16534 compound antigen,doses
R13212 T16534 T16531 pobj doses,with
R13213 T16396 T16397 amod chronic,disease
R13214 T16535 T16535 ROOT allowed,allowed
R13215 T16536 T16537 det the,development
R13216 T16537 T16535 dobj development,allowed
R13217 T16397 T16395 pobj disease,during
R13218 T16538 T16537 prep of,development
R13219 T16539 T16540 amod Th1,cells
R13220 T16540 T16538 pobj cells,of
R13221 T16398 T16383 punct .,offers
R13222 T16541 T16540 acl producing,cells
R13223 T16542 T16541 dobj IL-10,producing
R13224 T16543 T16535 prep in,allowed
R13225 T16544 T16546 det an,manner
R13226 T16545 T16546 amod IL-12-dependent,manner
R13227 T16546 T16543 pobj manner,in
R13228 T16399 T16414 acl Using,al.
R13229 T16547 T16535 punct .,allowed
R13230 T16548 T16549 compound IL-10,production
R13231 T16549 T16560 nsubj production,was
R13232 T16400 T16404 det an,model
R13233 T16550 T16549 prep by,production
R13234 T16551 T16552 amod Th1,cells
R13235 T16401 T16404 nmod in,model
R13236 T16552 T16550 pobj cells,by
R13237 T16553 T16552 acl induced,cells
R13238 T16554 T16553 agent by,induced
R13239 T16402 T16404 amod vivo,model
R13240 T16555 T16557 amod high,dose
R13241 T16556 T16557 compound antigen,dose
R13242 T16557 T16554 pobj dose,by
R13243 T16403 T16404 compound transfer,model
R13244 T16558 T16557 cc and,dose
R13245 T16559 T16557 conj IL-12,dose
R13246 T16404 T16399 dobj model,Using
R13247 T16560 T16560 ROOT was,was
R13248 T16561 T16560 acomp independent,was
R13249 T16562 T16561 prep of,independent
R13250 T16405 T16404 prep of,model
R13251 T16563 T16562 pobj IFN-γ,of
R13252 T16564 T16560 punct ",",was
R13253 T16565 T16560 prep in,was
R13254 T16406 T16405 pobj DO11,of
R13255 T16566 T16565 pobj keeping,in
R13256 T16567 T16566 prep with,keeping
R13257 T16407 T16408 nummod .10,TCR
R13258 T16568 T16569 amod previous,findings
R13259 T16569 T16567 pobj findings,with
R13260 T16570 T16573 punct (,al.
R13261 T16408 T16410 nmod TCR,cells
R13262 T16571 T16573 amod Jankovic,al.
R13263 T16572 T16573 nmod et,al.
R13264 T16573 T16569 appos al.,findings
R13265 T16409 T16410 amod transgenic,cells
R13266 T16574 T16573 punct ",",al.
R13267 T16575 T16573 npadvmod 2002,al.
R13268 T16576 T16560 punct ),was
R13269 T16410 T16404 conj cells,model
R13270 T16577 T16560 punct .,was
R13271 T16578 T16599 advmod However,suggested
R13272 T16411 T16414 punct (,al.
R13273 T16412 T16414 compound Castro,al.
R13274 T16579 T16599 punct ",",suggested
R13275 T16580 T16581 det a,role
R13276 T16581 T16599 nsubjpass role,suggested
R13277 T16582 T16581 prep for,role
R13278 T16413 T16414 nmod et,al.
R13279 T16583 T16582 pobj IFN-γ,for
R13280 T16584 T16581 prep in,role
R13281 T16414 T16420 advcl al.,showed
R13282 T16585 T16587 amod mediating,reactivation
R13283 T16586 T16587 compound IL-10,reactivation
R13284 T16587 T16584 pobj reactivation,in
R13285 T16588 T16581 prep by,role
R13286 T16415 T16414 punct ",",al.
R13287 T16589 T16590 amod Th1,cells
R13288 T16590 T16588 pobj cells,by
R13289 T16416 T16414 appos 2000,al.
R13290 T16591 T16581 prep during,role
R13291 T16592 T16593 amod secondary,infection
R13292 T16593 T16591 pobj infection,during
R13293 T16417 T16414 punct ),al.
R13294 T16594 T16593 prep with,infection
R13295 T16595 T16596 compound T.,gondii
R13296 T16418 T16420 punct ",",showed
R13297 T16596 T16594 pobj gondii,with
R13298 T16597 T16599 aux has,suggested
R13299 T16598 T16599 auxpass been,suggested
R13300 T16419 T16420 nsubj we,showed
R13301 T16599 T16599 ROOT suggested,suggested
R13302 T16600 T16599 punct (,suggested
R13303 T16601 T16603 compound Shaw,al.
R13304 T16420 T16420 ROOT showed,showed
R13305 T16602 T16603 nmod et,al.
R13306 T16603 T16606 dobj al.,)
R13307 T16604 T16603 punct ",",al.
R13308 T16421 T16426 mark that,differentiated
R13309 T16422 T16424 amod IL-10-producing,cells
R13310 T16605 T16603 npadvmod 2006,al.
R13311 T16606 T16599 punct ),suggested
R13312 T16423 T16424 amod Th1,cells
R13313 T16607 T16599 punct .,suggested
R13314 T16608 T16610 nsubj We,found
R13315 T16424 T16426 nsubjpass cells,differentiated
R13316 T16609 T16610 aux have,found
R13317 T16610 T16610 ROOT found,found
R13318 T16611 T16625 mark that,express
R13319 T16425 T16426 auxpass were,differentiated
R13320 T16612 T16615 nummod CD4,cells
R13321 T16613 T16615 nummod +,cells
R13322 T16426 T16420 ccomp differentiated,showed
R13323 T16614 T16615 compound T,cells
R13324 T16615 T16625 nsubj cells,express
R13325 T16616 T16615 acl exposed,cells
R13326 T16617 T16616 prep to,exposed
R13327 T16618 T16620 det a,dose
R13328 T16619 T16620 amod high,dose
R13329 T16620 T16617 pobj dose,to
R13330 T16427 T16426 prep in,differentiated
R13331 T16621 T16620 prep of,dose
R13332 T16622 T16621 pobj antigen,of
R13333 T16428 T16429 det the,presence
R13334 T16720 T16722 amod high-level,activation
R13335 T16623 T16625 aux do,express
R13336 T16721 T16722 compound TCR,activation
R13337 T16624 T16625 neg not,express
R13338 T16625 T16610 ccomp express,found
R13339 T16626 T16625 dobj IL-10,express
R13340 T16722 T16723 nsubj activation,feeds
R13341 T16627 T16625 prep upon,express
R13342 T16628 T16627 pobj restimulation,upon
R13343 T16723 T16717 ccomp feeds,suggests
R13344 T16629 T16610 punct ",",found
R13345 T16630 T16610 cc but,found
R13346 T16631 T16633 aux can,induced
R13347 T16724 T16723 advmod back,feeds
R13348 T16632 T16633 auxpass be,induced
R13349 T16633 T16610 conj induced,found
R13350 T16634 T16635 aux to,produce
R13351 T16725 T16724 prep to,back
R13352 T16635 T16633 xcomp produce,induced
R13353 T16636 T16635 dobj IL-10,produce
R13354 T16637 T16635 prep upon,produce
R13355 T16726 T16725 pobj upregulate,to
R13356 T16638 T16637 pobj re-exposure,upon
R13357 T16639 T16635 prep to,produce
R13358 T16640 T16642 det a,dose
R13359 T16727 T16728 amod IL-12,production
R13360 T16641 T16642 amod high,dose
R13361 T16642 T16639 pobj dose,to
R13362 T16643 T16642 prep of,dose
R13363 T16728 T16726 dobj production,upregulate
R13364 T16644 T16643 pobj antigen,of
R13365 T16645 T16642 prep in,dose
R13366 T16646 T16648 det the,phase
R13367 T16729 T16728 prep by,production
R13368 T16647 T16648 compound recall,phase
R13369 T16648 T16645 pobj phase,in
R13370 T16649 T16633 prep in,induced
R13371 T16730 T16729 pobj DC,by
R13372 T16650 T16651 det the,absence
R13373 T16651 T16649 pobj absence,in
R13374 T16652 T16651 prep of,absence
R13375 T16653 T16654 amod added,IL-12
R13376 T16654 T16652 pobj IL-12,of
R13377 T16655 T16610 punct .,found
R13378 T16731 T16717 punct .,suggests
R13379 T16656 T16659 advmod However,is
R13380 T16657 T16659 punct ",",is
R13381 T16732 T16733 nsubj It,is
R13382 T16733 T16733 ROOT is,is
R13383 T16734 T16735 advmod thus,likely
R13384 T16658 T16659 nsubj this,is
R13385 T16659 T16659 ROOT is,is
R13386 T16735 T16733 acomp likely,is
R13387 T16660 T16659 acomp dependent,is
R13388 T16661 T16660 prep on,dependent
R13389 T16662 T16663 det the,induction
R13390 T16736 T16756 mark that,induce
R13391 T16663 T16661 pobj induction,on
R13392 T16664 T16663 prep of,induction
R13393 T16737 T16756 prep in,induce
R13394 T16665 T16664 pobj IL-12,of
R13395 T16666 T16663 prep by,induction
R13396 T16667 T16668 amod antigen-presenting,DCs
R13397 T16738 T16739 compound T.,gondii
R13398 T16668 T16666 pobj DCs,by
R13399 T16669 T16659 punct .,is
R13400 T16670 T16671 det The,combination
R13401 T16671 T16679 nsubj combination,resulted
R13402 T16672 T16671 prep of,combination
R13403 T16739 T16740 compound gondii,infection
R13404 T16673 T16676 det both,dose
R13405 T16674 T16675 amod high,antigen
R13406 T16675 T16676 compound antigen,dose
R13407 T16676 T16672 pobj dose,of
R13408 T16740 T16737 pobj infection,in
R13409 T16677 T16676 cc and,dose
R13410 T16678 T16676 conj IL-12,dose
R13411 T16679 T16679 ROOT resulted,resulted
R13412 T16741 T16740 prep in,infection
R13413 T16680 T16679 prep in,resulted
R13414 T16681 T16683 det the,levels
R13415 T16742 T16741 pobj vivo,in
R13416 T16682 T16683 amod highest,levels
R13417 T16683 T16680 pobj levels,in
R13418 T16684 T16683 prep of,levels
R13419 T16743 T16746 punct (,al.
R13420 T16685 T16686 amod IL-10,production
R13421 T16686 T16684 pobj production,of
R13422 T16744 T16746 compound Shaw,al.
R13423 T16745 T16746 nmod et,al.
R13424 T16687 T16679 cc and,resulted
R13425 T16688 T16679 conj correlated,resulted
R13426 T16746 T16737 pobj al.,in
R13427 T16747 T16746 punct ",",al.
R13428 T16689 T16688 prep with,correlated
R13429 T16748 T16746 npadvmod 2006,al.
R13430 T16690 T16692 det the,levels
R13431 T16749 T16746 punct ),al.
R13432 T16750 T16756 punct ",",induce
R13433 T16691 T16692 amod high,levels
R13434 T16751 T16752 det the,requirement
R13435 T16692 T16689 pobj levels,with
R13436 T16752 T16756 nsubj requirement,induce
R13437 T16753 T16756 mark for,induce
R13438 T16693 T16692 prep of,levels
R13439 T16754 T16756 nsubj IFN-γ,induce
R13440 T16755 T16756 aux to,induce
R13441 T16694 T16693 pobj ERK1,of
R13442 T16756 T16735 ccomp induce,likely
R13443 T16757 T16756 dobj IL-10,induce
R13444 T16695 T16694 cc and,ERK1
R13445 T16758 T16759 punct ",",was
R13446 T16696 T16697 nummod ERK2,activation
R13447 T16697 T16694 conj activation,ERK1
R13448 T16698 T16679 punct .,resulted
R13449 T16759 T16733 conj was,is
R13450 T16699 T16701 det The,expression
R13451 T16700 T16701 amod increased,expression
R13452 T16701 T16704 nsubj expression,observed
R13453 T16760 T16759 prep for,was
R13454 T16702 T16701 prep of,expression
R13455 T16703 T16704 amod IFN-γ,observed
R13456 T16704 T16704 ROOT observed,observed
R13457 T16761 T16760 pobj feedback,for
R13458 T16705 T16704 prep during,observed
R13459 T16706 T16708 det the,phase
R13460 T16762 T16759 attr upregulation,was
R13461 T16707 T16708 amod secondary,phase
R13462 T16708 T16705 pobj phase,during
R13463 T16709 T16710 aux will,induce
R13464 T16763 T16762 prep of,upregulation
R13465 T16710 T16704 ccomp induce,observed
R13466 T16711 T16713 amod increased,production
R13467 T16712 T16713 amod IL-12,production
R13468 T16764 T16763 pobj IL-12,of
R13469 T16713 T16710 dobj production,induce
R13470 T16714 T16713 prep by,production
R13471 T16715 T16714 pobj DCs,by
R13472 T16765 T16762 prep by,upregulation
R13473 T16716 T16710 cc and,induce
R13474 T16717 T16710 conj suggests,induce
R13475 T16718 T16723 mark that,feeds
R13476 T16719 T16722 amod repeated,activation
R13477 T16766 T16765 pobj DCs,by
R13478 T16767 T16766 punct ",",DCs
R13479 T16768 T16771 nsubj which,induced
R13480 T16769 T16771 prep in,induced
R13481 T16770 T16769 pobj turn,in
R13482 T16817 T16819 det the,basis
R13483 T16771 T16766 relcl induced,DCs
R13484 T16818 T16819 amod molecular,basis
R13485 T16819 T16822 nsubj basis,is
R13486 T16772 T16771 dobj IL-10,induced
R13487 T16820 T16819 prep for,basis
R13488 T16821 T16820 pobj these,for
R13489 T16773 T16771 prep in,induced
R13490 T16822 T16809 conj is,suggest
R13491 T16823 T16825 advmod as,unclear
R13492 T16824 T16825 advmod yet,unclear
R13493 T16774 T16776 det the,cells
R13494 T16825 T16822 acomp unclear,is
R13495 T16826 T16822 punct .,is
R13496 T16775 T16776 amod Th1,cells
R13497 T16827 T16828 compound Costimulatory,OX-40
R13498 T16828 T16829 compound OX-40,signals
R13499 T16829 T16832 nsubjpass signals,shown
R13500 T16776 T16773 pobj cells,in
R13501 T16830 T16832 aux have,shown
R13502 T16831 T16832 auxpass been,shown
R13503 T16832 T16832 ROOT shown,shown
R13504 T16777 T16759 punct .,was
R13505 T16833 T16835 aux to,regulate
R13506 T16834 T16835 advmod negatively,regulate
R13507 T16835 T16832 xcomp regulate,shown
R13508 T16778 T16783 mark Although,regulated
R13509 T16836 T16837 amod IL-10,production
R13510 T16837 T16835 dobj production,regulate
R13511 T16838 T16841 punct (,al.
R13512 T16779 T16783 nsubjpass IL-10,regulated
R13513 T16839 T16841 compound Ito,al.
R13514 T16840 T16841 nmod et,al.
R13515 T16780 T16783 aux may,regulated
R13516 T16841 T16835 parataxis al.,regulate
R13517 T16842 T16841 punct ",",al.
R13518 T16843 T16841 npadvmod 2005,al.
R13519 T16781 T16783 auxpass be,regulated
R13520 T16844 T16841 punct ),al.
R13521 T16845 T16846 preconj both,in
R13522 T16846 T16835 prep in,regulate
R13523 T16782 T16783 advmod differentially,regulated
R13524 T16847 T16846 pobj Th1,in
R13525 T16848 T16847 cc and,Th1
R13526 T16849 T16847 conj Th2,Th1
R13527 T16850 T16846 pobj cells,in
R13528 T16851 T16832 punct ",",shown
R13529 T16852 T16857 mark whereas,suggested
R13530 T16783 T16809 advcl regulated,suggest
R13531 T16853 T16854 compound ICOS,signaling
R13532 T16854 T16857 nsubjpass signaling,suggested
R13533 T16855 T16857 aux has,suggested
R13534 T16784 T16783 prep in,regulated
R13535 T16856 T16857 auxpass been,suggested
R13536 T16857 T16832 advcl suggested,shown
R13537 T16858 T16859 aux to,induce
R13538 T16785 T16784 pobj Th1,in
R13539 T16859 T16857 xcomp induce,suggested
R13540 T16786 T16785 cc and,Th1
R13541 T16787 T16785 conj Th2,Th1
R13542 T16860 T16859 dobj IL-10,induce
R13543 T16861 T16864 punct (,al.
R13544 T16862 T16864 compound Ito,al.
R13545 T16788 T16783 npadvmod cells,regulated
R13546 T16863 T16864 nmod et,al.
R13547 T16864 T16870 compound al.,al.
R13548 T16865 T16864 punct ",",al.
R13549 T16789 T16792 mark as,reported
R13550 T16866 T16864 npadvmod 2007,al.
R13551 T16867 T16864 punct ;,al.
R13552 T16868 T16870 compound Witsch,al.
R13553 T16790 T16792 aux has,reported
R13554 T16869 T16870 compound et,al.
R13555 T16870 T16859 advmod al.,induce
R13556 T16871 T16870 punct ",",al.
R13557 T16791 T16792 auxpass been,reported
R13558 T16872 T16870 npadvmod 2002,al.
R13559 T16873 T16859 punct ),induce
R13560 T16874 T16857 prep in,suggested
R13561 T16792 T16783 advcl reported,regulated
R13562 T16875 T16876 det both,Th1
R13563 T16876 T16874 pobj Th1,in
R13564 T16877 T16876 cc and,Th1
R13565 T16878 T16879 nummod Th2,cells
R13566 T16793 T16809 punct (,suggest
R13567 T16879 T16876 conj cells,Th1
R13568 T16880 T16832 punct .,shown
R13569 T16881 T16890 advmod However,regulates
R13570 T16882 T16890 punct ",",regulates
R13571 T16794 T16796 compound Chang,al.
R13572 T16883 T16890 prep in,regulates
R13573 T16884 T16885 det some,cases
R13574 T16795 T16796 nmod et,al.
R13575 T16885 T16883 pobj cases,in
R13576 T16886 T16890 punct ",",regulates
R13577 T16887 T16888 compound ICOS,signaling
R13578 T16888 T16890 nsubj signaling,regulates
R13579 T16796 T16809 ccomp al.,suggest
R13580 T16889 T16890 advmod also,regulates
R13581 T16890 T16890 ROOT regulates,regulates
R13582 T16891 T16892 amod IL-4,production
R13583 T16797 T16796 punct ",",al.
R13584 T16892 T16890 dobj production,regulates
R13585 T16893 T16892 cc and,production
R13586 T16798 T16796 npadvmod 2007,al.
R13587 T16894 T16895 amod Th2,responses
R13588 T16895 T16892 conj responses,production
R13589 T16896 T16899 punct (,al.
R13590 T16799 T16809 punct ;,suggest
R13591 T16897 T16899 compound Greenwald,al.
R13592 T16898 T16899 nmod et,al.
R13593 T16800 T16802 compound Wang,al.
R13594 T16899 T16890 dep al.,regulates
R13595 T16900 T16899 punct ",",al.
R13596 T16801 T16802 compound et,al.
R13597 T16901 T16899 npadvmod 2005,al.
R13598 T16902 T16899 punct ),al.
R13599 T16903 T16890 punct .,regulates
R13600 T16904 T16906 nsubj We,provide
R13601 T16802 T16809 prep al.,suggest
R13602 T16905 T16906 advmod now,provide
R13603 T16906 T16906 ROOT provide,provide
R13604 T16907 T16909 det a,mechanism
R13605 T16803 T16802 punct ",",al.
R13606 T16908 T16909 amod common,mechanism
R13607 T16909 T16906 dobj mechanism,provide
R13608 T16910 T16909 prep of,mechanism
R13609 T16804 T16802 npadvmod 2005,al.
R13610 T16911 T16910 pobj ERK1,of
R13611 T16912 T16911 cc and,ERK1
R13612 T16805 T16802 punct ),al.
R13613 T16913 T16911 conj ERK2,ERK1
R13614 T16806 T16809 punct ",",suggest
R13615 T16807 T16808 det some,studies
R13616 T16914 T16910 pobj activation,of
R13617 T16808 T16809 nsubj studies,suggest
R13618 T16915 T16906 prep for,provide
R13619 T16916 T16917 det the,regulation
R13620 T16917 T16915 pobj regulation,for
R13621 T16809 T16809 ROOT suggest,suggest
R13622 T16918 T16917 prep of,regulation
R13623 T16919 T16920 amod IL-10,production
R13624 T16920 T16918 pobj production,of
R13625 T16810 T16811 det the,existence
R13626 T16921 T16920 prep in,production
R13627 T16922 T16921 pobj Th1,in
R13628 T16923 T16922 punct ",",Th1
R13629 T16924 T16922 conj Th2,Th1
R13630 T16925 T16924 punct ",",Th2
R13631 T16926 T16924 cc and,Th2
R13632 T16811 T16809 dobj existence,suggest
R13633 T16927 T16924 conj Th17,Th2
R13634 T16928 T16918 pobj cells,of
R13635 T16929 T16906 punct ",",provide
R13636 T16930 T16933 mark although,differentiates
R13637 T16812 T16811 prep of,existence
R13638 T16931 T16932 det each,subset
R13639 T16932 T16933 nsubj subset,differentiates
R13640 T16813 T16814 amod common,pathways
R13641 T16933 T16906 advcl differentiates,provide
R13642 T16934 T16933 prep along,differentiates
R13643 T16935 T16940 det a,pathway
R13644 T16814 T16812 pobj pathways,of
R13645 T16936 T16940 amod distinct,pathway
R13646 T16937 T16936 cc and,distinct
R13647 T16938 T16936 conj subset-specific,distinct
R13648 T16815 T16809 punct ",",suggest
R13649 T16939 T16940 amod transcriptional,pathway
R13650 T16816 T16809 cc but,suggest
R13651 T16940 T16934 pobj pathway,along
R13652 T16941 T16906 punct .,provide
R13653 T16942 T16943 nsubj This,reinforces
R13654 T16943 T16943 ROOT reinforces,reinforces
R13655 T17011 T17010 pobj IL-10,of
R13656 T16944 T16945 det the,fact
R13657 T16945 T16943 dobj fact,reinforces
R13658 T16946 T16948 mark that,is
R13659 T16947 T16948 nsubj IL-10,is
R13660 T16948 T16945 acl is,fact
R13661 T17012 T17011 prep in,IL-10
R13662 T16949 T16948 neg not,is
R13663 T16950 T16953 det a,cytokine
R13664 T16951 T16953 nmod Th,cytokine
R13665 T16952 T16953 amod cell-subset-specific,cytokine
R13666 T17013 T17012 pobj Th1,in
R13667 T16953 T16948 attr cytokine,is
R13668 T16954 T16948 punct ",",is
R13669 T16955 T16948 cc but,is
R13670 T17014 T17013 cc and,Th1
R13671 T16956 T16958 advmod instead,produced
R13672 T17015 T17013 conj Th2,Th1
R13673 T16957 T16958 auxpass is,produced
R13674 T16958 T16948 conj produced,is
R13675 T16959 T16958 prep in,produced
R13676 T16960 T16963 det a,fashion
R13677 T16961 T16962 advmod tightly,regulated
R13678 T16962 T16963 amod regulated,fashion
R13679 T16963 T16959 pobj fashion,in
R13680 T16964 T16958 prep during,produced
R13681 T17016 T17010 pobj cells,of
R13682 T16965 T16967 det each,pathway
R13683 T16966 T16967 compound differentiation,pathway
R13684 T16967 T16964 pobj pathway,during
R13685 T16968 T16943 punct .,reinforces
R13686 T17017 T17019 aux has,suggested
R13687 T17018 T17019 auxpass been,suggested
R13688 T16969 T16988 prep Of,described
R13689 T16970 T16969 pobj note,Of
R13690 T16971 T16988 punct ",",described
R13691 T17019 T17019 ROOT suggested,suggested
R13692 T17020 T17029 punct (,al.
R13693 T16972 T16973 det a,role
R13694 T16973 T16988 nsubjpass role,described
R13695 T17021 T17023 compound Chang,al.
R13696 T16974 T16973 prep for,role
R13697 T16975 T16978 nummod ERK1,activation
R13698 T16976 T16975 cc and,ERK1
R13699 T17022 T17023 nmod et,al.
R13700 T16977 T16975 conj ERK2,ERK1
R13701 T16978 T16974 pobj activation,for
R13702 T16979 T16978 prep in,activation
R13703 T17023 T17029 ccomp al.,al.
R13704 T16980 T16981 det the,induction
R13705 T16981 T16979 pobj induction,in
R13706 T16982 T16981 prep of,induction
R13707 T17024 T17023 punct ",",al.
R13708 T16983 T16984 compound IL-10,production
R13709 T16984 T16982 pobj production,of
R13710 T16985 T16988 aux has,described
R13711 T17025 T17023 npadvmod 2007,al.
R13712 T17026 T17029 punct ;,al.
R13713 T16986 T16988 advmod already,described
R13714 T16987 T16988 auxpass been,described
R13715 T17027 T17029 compound Wang,al.
R13716 T16988 T16988 ROOT described,described
R13717 T16989 T16988 prep for,described
R13718 T16990 T16989 pobj macrophages,for
R13719 T17028 T17029 compound et,al.
R13720 T16991 T16990 cc and,macrophages
R13721 T16992 T16990 conj DC,macrophages
R13722 T17029 T17029 ROOT al.,al.
R13723 T16993 T16992 punct (,DC
R13724 T16994 T16996 compound Agrawal,al.
R13725 T17030 T17029 punct ",",al.
R13726 T16995 T16996 nmod et,al.
R13727 T16996 T16992 appos al.,DC
R13728 T16997 T16996 punct ",",al.
R13729 T16998 T16996 appos 2006,al.
R13730 T16999 T16992 punct ;,DC
R13731 T17000 T17002 compound Hacker,al.
R13732 T17031 T17029 npadvmod 2005,al.
R13733 T17001 T17002 nmod et,al.
R13734 T17002 T16992 conj al.,DC
R13735 T17003 T17002 punct ",",al.
R13736 T17032 T17029 punct ),al.
R13737 T17004 T17002 npadvmod 1999,al.
R13738 T17005 T17002 punct ),al.
R13739 T17006 T16988 punct .,described
R13740 T17033 T17029 punct ",",al.
R13741 T17007 T17019 nsubj Differential,suggested
R13742 T17008 T17009 amod transcriptional,regulation
R13743 T17009 T17019 nsubjpass regulation,suggested
R13744 T17034 T17029 cc and,al.
R13745 T17010 T17009 prep of,regulation
R13746 T17035 T17037 amod extensive,acetylation
R13747 T17036 T17037 compound histone,acetylation
R13748 T17037 T17042 nsubj acetylation,is
R13749 T17038 T17037 prep of,acetylation
R13750 T17108 T17063 punct .,provide
R13751 T17109 T17113 nsubjpass It,shown
R13752 T17110 T17113 aux has,shown
R13753 T17039 T17041 det the,gene
R13754 T17111 T17113 advmod also,shown
R13755 T17112 T17113 auxpass been,shown
R13756 T17040 T17041 compound IL-10,gene
R13757 T17113 T17113 ROOT shown,shown
R13758 T17114 T17119 mark that,is
R13759 T17115 T17119 nsubj maintenance,is
R13760 T17041 T17038 pobj gene,of
R13761 T17116 T17115 prep of,maintenance
R13762 T17117 T17118 compound IL-10,expression
R13763 T17118 T17116 pobj expression,of
R13764 T17042 T17029 conj is,al.
R13765 T17119 T17113 ccomp is,shown
R13766 T17120 T17119 acomp conditional,is
R13767 T17043 T17042 acomp detectable,is
R13768 T17121 T17120 prep on,conditional
R13769 T17122 T17121 pobj IL-12,on
R13770 T17123 T17122 cc or,IL-12
R13771 T17044 T17043 prep in,detectable
R13772 T17124 T17122 conj IL-4,IL-12
R13773 T17125 T17130 mark unless,imprinted
R13774 T17045 T17046 advmod fully,polarized
R13775 T17126 T17128 det the,gene
R13776 T17127 T17128 compound IL-10,gene
R13777 T17128 T17130 nsubjpass gene,imprinted
R13778 T17129 T17130 auxpass is,imprinted
R13779 T17130 T17119 advcl imprinted,is
R13780 T17131 T17130 agent by,imprinted
R13781 T17046 T17048 amod polarized,cells
R13782 T17132 T17131 pobj GATA-3,by
R13783 T17133 T17136 punct (,al.
R13784 T17134 T17136 compound Chang,al.
R13785 T17047 T17048 amod Th2,cells
R13786 T17135 T17136 nmod et,al.
R13787 T17136 T17130 npadvmod al.,imprinted
R13788 T17048 T17044 pobj cells,in
R13789 T17137 T17136 punct ",",al.
R13790 T17138 T17136 npadvmod 2007,al.
R13791 T17139 T17136 punct ),al.
R13792 T17049 T17042 punct ",",is
R13793 T17140 T17136 punct ",",al.
R13794 T17141 T17143 nsubj which,remodel
R13795 T17142 T17143 aux can,remodel
R13796 T17050 T17042 cc but,is
R13797 T17051 T17052 neg not,Th1
R13798 T17143 T17136 relcl remodel,al.
R13799 T17144 T17146 det the,locus
R13800 T17052 T17053 amod Th1,cells
R13801 T17145 T17146 compound IL-10,locus
R13802 T17146 T17143 dobj locus,remodel
R13803 T17053 T17042 conj cells,is
R13804 T17147 T17136 punct ",",al.
R13805 T17148 T17149 advmod thus,explaining
R13806 T17149 T17136 acl explaining,al.
R13807 T17054 T17042 punct (,is
R13808 T17150 T17152 det the,amounts
R13809 T17151 T17152 amod highest,amounts
R13810 T17055 T17057 compound Chang,al.
R13811 T17152 T17149 dobj amounts,explaining
R13812 T17153 T17152 prep of,amounts
R13813 T17154 T17153 pobj IL-10,of
R13814 T17056 T17057 nmod et,al.
R13815 T17155 T17154 acl produced,IL-10
R13816 T17156 T17155 agent by,produced
R13817 T17157 T17158 amod Th2,cells
R13818 T17057 T17042 dep al.,is
R13819 T17058 T17057 punct ",",al.
R13820 T17158 T17156 pobj cells,by
R13821 T17059 T17057 npadvmod 2007,al.
R13822 T17159 T17162 punct (,al.
R13823 T17160 T17162 compound Chang,al.
R13824 T17060 T17042 punct ),is
R13825 T17161 T17162 nmod et,al.
R13826 T17162 T17168 compound al.,al.
R13827 T17163 T17162 punct ",",al.
R13828 T17164 T17162 npadvmod 2007,al.
R13829 T17165 T17162 punct ;,al.
R13830 T17061 T17029 punct .,al.
R13831 T17166 T17168 compound Shoemaker,al.
R13832 T17167 T17168 compound et,al.
R13833 T17168 T17152 acl al.,amounts
R13834 T17062 T17063 nsubj We,provide
R13835 T17169 T17168 punct ",",al.
R13836 T17170 T17168 npadvmod 2006,al.
R13837 T17063 T17063 ROOT provide,provide
R13838 T17171 T17152 punct ),amounts
R13839 T17172 T17113 punct .,shown
R13840 T17064 T17063 dobj evidence,provide
R13841 T17173 T17174 nsubj We,show
R13842 T17065 T17068 mark that,produced
R13843 T17174 T17174 ROOT show,show
R13844 T17066 T17068 nsubjpass IL-10,produced
R13845 T17175 T17174 advmod here,show
R13846 T17176 T17179 det that,dose
R13847 T17177 T17178 amod high,antigen
R13848 T17067 T17068 auxpass is,produced
R13849 T17178 T17179 compound antigen,dose
R13850 T17179 T17183 nsubj dose,downregulate
R13851 T17068 T17064 acl produced,evidence
R13852 T17180 T17179 cc and,dose
R13853 T17181 T17179 conj IL-12,dose
R13854 T17182 T17183 advmod drastically,downregulate
R13855 T17183 T17174 advcl downregulate,show
R13856 T17069 T17068 prep in,produced
R13857 T17184 T17185 amod Gata-3,expression
R13858 T17185 T17183 dobj expression,downregulate
R13859 T17186 T17183 punct ",",downregulate
R13860 T17070 T17072 amod canonical,cells
R13861 T17187 T17183 advcl suggesting,downregulate
R13862 T17188 T17191 mark that,are
R13863 T17189 T17190 amod additional,factors
R13864 T17071 T17072 amod Th1,cells
R13865 T17190 T17191 nsubj factors,are
R13866 T17191 T17187 ccomp are,suggesting
R13867 T17072 T17069 pobj cells,in
R13868 T17192 T17191 prep in,are
R13869 T17073 T17068 cc and,produced
R13870 T17193 T17192 pobj place,in
R13871 T17074 T17077 mark that,correlates
R13872 T17075 T17076 poss its,expression
R13873 T17194 T17195 aux to,induce
R13874 T17195 T17191 advcl induce,are
R13875 T17196 T17197 amod IL-10,expression
R13876 T17076 T17077 nsubj expression,correlates
R13877 T17197 T17195 dobj expression,induce
R13878 T17198 T17195 prep in,induce
R13879 T17199 T17200 amod Th1,cells
R13880 T17200 T17198 pobj cells,in
R13881 T17201 T17195 punct ",",induce
R13882 T17202 T17195 prep albeit,induce
R13883 T17077 T17064 acl correlates,evidence
R13884 T17203 T17202 mark transiently,albeit
R13885 T17204 T17174 punct .,show
R13886 T17078 T17077 prep with,correlates
R13887 T17079 T17080 det the,expression
R13888 T17205 T17210 nsubjpass Expression,diminished
R13889 T17080 T17078 pobj expression,with
R13890 T17206 T17205 prep of,Expression
R13891 T17207 T17206 pobj c-maf,of
R13892 T17208 T17210 auxpass was,diminished
R13893 T17081 T17080 prep of,expression
R13894 T17209 T17210 advmod greatly,diminished
R13895 T17210 T17210 ROOT diminished,diminished
R13896 T17211 T17210 agent by,diminished
R13897 T17082 T17081 pobj T-bet,of
R13898 T17212 T17213 amod high,antigen
R13899 T17213 T17214 compound antigen,doses
R13900 T17083 T17080 cc and,expression
R13901 T17214 T17211 pobj doses,by
R13902 T17215 T17214 prep in,doses
R13903 T17216 T17217 compound T,cells
R13904 T17084 T17087 det the,production
R13905 T17217 T17215 pobj cells,in
R13906 T17218 T17210 cc and,diminished
R13907 T17219 T17222 advmod yet,maintained
R13908 T17085 T17087 amod highest,production
R13909 T17220 T17222 auxpass was,maintained
R13910 T17221 T17222 advmod unexpectedly,maintained
R13911 T17222 T17210 conj maintained,diminished
R13912 T17086 T17087 compound IFN-γ,production
R13913 T17087 T17080 conj production,expression
R13914 T17223 T17222 agent by,maintained
R13915 T17088 T17087 punct ",",production
R13916 T17224 T17223 pobj IL-12,by
R13917 T17225 T17224 cc and,IL-12
R13918 T17226 T17224 conj present,IL-12
R13919 T17089 T17087 prep in,production
R13920 T17227 T17226 prep in,present
R13921 T17228 T17229 compound Th17,cells
R13922 T17229 T17227 pobj cells,in
R13923 T17090 T17089 pobj keeping,in
R13924 T17230 T17222 punct .,maintained
R13925 T17231 T17233 det That,expression
R13926 T17091 T17090 prep with,keeping
R13927 T17232 T17233 amod c-maf,expression
R13928 T17233 T17234 nsubj expression,is
R13929 T17234 T17234 ROOT is,is
R13930 T17235 T17234 acomp common,is
R13931 T17236 T17237 aux to,IL-10-producing
R13932 T17237 T17234 xcomp IL-10-producing,is
R13933 T17092 T17093 poss our,observations
R13934 T17238 T17237 dobj Th1,IL-10-producing
R13935 T17239 T17238 punct ",",Th1
R13936 T17240 T17238 conj Th2,Th1
R13937 T17093 T17091 pobj observations,with
R13938 T17241 T17240 punct ",",Th2
R13939 T17242 T17240 cc and,Th2
R13940 T17243 T17240 conj Th17,Th2
R13941 T17244 T17237 dobj cells,IL-10-producing
R13942 T17094 T17102 mark that,required
R13943 T17245 T17237 cc and,IL-10-producing
R13944 T17246 T17237 punct ",",IL-10-producing
R13945 T17095 T17097 amod high-dose,stimulation
R13946 T17247 T17237 prep like,IL-10-producing
R13947 T17248 T17247 pobj IL-10,like
R13948 T17249 T17234 punct ",",is
R13949 T17096 T17097 compound antigen,stimulation
R13950 T17250 T17263 csubj is,is
R13951 T17251 T17250 acomp dependent,is
R13952 T17252 T17251 prep on,dependent
R13953 T17097 T17102 nsubjpass stimulation,required
R13954 T17253 T17254 compound ERK,activation
R13955 T17254 T17252 pobj activation,on
R13956 T17255 T17254 prep in,activation
R13957 T17098 T17097 cc and,stimulation
R13958 T17256 T17255 pobj Th1,in
R13959 T17257 T17256 cc and,Th1
R13960 T17258 T17256 conj Th17,Th1
R13961 T17099 T17097 conj IL-12,stimulation
R13962 T17259 T17254 conj cells,activation
R13963 T17260 T17251 prep for,dependent
R13964 T17261 T17262 poss its,expression
R13965 T17100 T17097 acl signaling,stimulation
R13966 T17262 T17260 pobj expression,for
R13967 T17263 T17234 conj is,is
R13968 T17264 T17263 prep of,is
R13969 T17101 T17102 auxpass are,required
R13970 T17265 T17264 pobj interest,of
R13971 T17266 T17270 mark because,shown
R13972 T17267 T17270 nsubjpass c-Maf,shown
R13973 T17102 T17063 ccomp required,provide
R13974 T17268 T17270 aux has,shown
R13975 T17269 T17270 auxpass been,shown
R13976 T17103 T17102 prep for,required
R13977 T17270 T17263 advcl shown,is
R13978 T17104 T17103 pobj IL-10,for
R13979 T17105 T17104 cc and,IL-10
R13980 T17271 T17272 aux to,be
R13981 T17272 T17270 xcomp be,shown
R13982 T17106 T17107 compound IFN-γ,expression
R13983 T17273 T17276 det an,factor
R13984 T17107 T17104 conj expression,IL-10
R13985 T17302 T17303 compound Th17,CD4
R13986 T17274 T17276 amod essential,factor
R13987 T17275 T17276 compound transcription,factor
R13988 T17276 T17272 attr factor,be
R13989 T17277 T17276 prep for,factor
R13990 T17278 T17279 compound IL-10,expression
R13991 T17303 T17299 conj CD4,Th2
R13992 T17279 T17277 pobj expression,for
R13993 T17280 T17279 prep in,expression
R13994 T17304 T17320 advcl +,induced
R13995 T17281 T17280 pobj macrophages,in
R13996 T17282 T17285 punct (,al.
R13997 T17283 T17285 compound Cao,al.
R13998 T17305 T17306 compound T,cell
R13999 T17284 T17285 nmod et,al.
R14000 T17285 T17276 appos al.,factor
R14001 T17306 T17307 compound cell,subsets
R14002 T17307 T17308 nsubj subsets,differentiate
R14003 T17286 T17285 punct ",",al.
R14004 T17287 T17285 npadvmod 2005,al.
R14005 T17308 T17304 ccomp differentiate,+
R14006 T17288 T17263 punct ),is
R14007 T17289 T17263 punct .,is
R14008 T17290 T17294 prep In,show
R14009 T17309 T17308 prep along,differentiate
R14010 T17291 T17290 pobj summary,In
R14011 T17292 T17294 punct ",",show
R14012 T17293 T17294 nsubj we,show
R14013 T17310 T17311 amod distinct,signaling
R14014 T17294 T17294 ROOT show,show
R14015 T17295 T17320 mark that,induced
R14016 T17311 T17309 pobj signaling,along
R14017 T17296 T17304 mark although,+
R14018 T17297 T17304 nsubj Th1,+
R14019 T17298 T17299 punct ",",Th2
R14020 T17312 T17311 cc and,signaling
R14021 T17299 T17297 conj Th2,Th1
R14022 T17300 T17299 punct ",",Th2
R14023 T17301 T17299 cc and,Th2
R14024 T17313 T17314 amod transcriptional,pathways
R14025 T17314 T17311 conj pathways,signaling
R14026 T17315 T17320 punct ",",induced
R14027 T17316 T17320 nsubjpass they,induced
R14028 T17399 T17381 punct ",",provides
R14029 T17400 T17402 aux to,regulate
R14030 T17401 T17402 advmod tightly,regulate
R14031 T17402 T17381 advcl regulate,provides
R14032 T17317 T17320 aux can,induced
R14033 T17403 T17404 det the,production
R14034 T17404 T17402 dobj production,regulate
R14035 T17318 T17320 dep all,induced
R14036 T17405 T17404 prep of,production
R14037 T17406 T17405 pobj IL-10,of
R14038 T17407 T17410 mark so,allow
R14039 T17319 T17320 auxpass be,induced
R14040 T17408 T17410 mark as,allow
R14041 T17409 T17410 aux to,allow
R14042 T17410 T17402 advcl allow,regulate
R14043 T17320 T17294 ccomp induced,show
R14044 T17411 T17413 det a,response
R14045 T17412 T17413 amod protective,response
R14046 T17413 T17415 nsubj response,eradicate
R14047 T17321 T17322 aux to,make
R14048 T17414 T17415 aux to,eradicate
R14049 T17415 T17410 ccomp eradicate,allow
R14050 T17416 T17417 det a,pathogen
R14051 T17322 T17320 xcomp make,induced
R14052 T17417 T17415 dobj pathogen,eradicate
R14053 T17418 T17415 prep with,eradicate
R14054 T17419 T17420 amod minimal,damage
R14055 T17323 T17322 dobj IL-10,make
R14056 T17420 T17418 pobj damage,with
R14057 T17421 T17420 prep to,damage
R14058 T17422 T17423 det the,host
R14059 T17324 T17294 punct .,show
R14060 T17423 T17421 pobj host,to
R14061 T17424 T17415 cc and,eradicate
R14062 T17425 T17426 advmod also,prevent
R14063 T17325 T17328 nummod ERK1,activation
R14064 T17426 T17415 conj prevent,eradicate
R14065 T17427 T17428 amod chronic,infection
R14066 T17428 T17426 dobj infection,prevent
R14067 T17326 T17325 cc and,ERK1
R14068 T17429 T17381 punct .,provides
R14069 T17430 T17434 advmod Moreover,have
R14070 T17431 T17434 punct ",",have
R14071 T17327 T17325 conj ERK2,ERK1
R14072 T17432 T17433 poss our,findings
R14073 T17433 T17434 nsubj findings,have
R14074 T17434 T17434 ROOT have,have
R14075 T17328 T17330 nsubjpass activation,required
R14076 T17435 T17436 amod important,implications
R14077 T17436 T17434 dobj implications,have
R14078 T17437 T17436 prep for,implications
R14079 T17438 T17439 det the,regulation
R14080 T17439 T17437 pobj regulation,for
R14081 T17440 T17439 prep of,regulation
R14082 T17329 T17330 auxpass is,required
R14083 T17441 T17442 amod IL-10,production
R14084 T17442 T17440 pobj production,of
R14085 T17330 T17330 ROOT required,required
R14086 T17331 T17330 prep for,required
R14087 T17443 T17434 prep during,have
R14088 T17444 T17447 det an,response
R14089 T17445 T17447 amod inflammatory,response
R14090 T17446 T17447 amod Th1,response
R14091 T17332 T17333 compound IL-10,production
R14092 T17447 T17443 pobj response,during
R14093 T17333 T17331 pobj production,for
R14094 T17448 T17447 prep in,response
R14095 T17334 T17330 agent by,required
R14096 T17449 T17448 pobj infection,in
R14097 T17335 T17339 predet all,subsets
R14098 T17450 T17434 cc and,have
R14099 T17336 T17339 det these,subsets
R14100 T17337 T17339 compound Th,subsets
R14101 T17451 T17452 aux may,be
R14102 T17338 T17339 compound cell,subsets
R14103 T17339 T17334 pobj subsets,by
R14104 T17452 T17434 conj be,have
R14105 T17340 T17330 punct .,required
R14106 T17453 T17452 prep of,be
R14107 T17341 T17354 prep With,provide
R14108 T17342 T17341 pobj regard,With
R14109 T17454 T17453 pobj relevance,of
R14110 T17343 T17342 prep to,regard
R14111 T17455 T17454 prep for,relevance
R14112 T17344 T17345 det the,expression
R14113 T17456 T17457 det the,design
R14114 T17345 T17343 pobj expression,to
R14115 T17346 T17345 prep of,expression
R14116 T17457 T17455 pobj design,for
R14117 T17347 T17346 pobj IL-10,of
R14118 T17458 T17457 prep of,design
R14119 T17348 T17345 prep by,expression
R14120 T17459 T17458 pobj vaccines,of
R14121 T17349 T17350 amod Th1,cells
R14122 T17460 T17455 cc and,for
R14123 T17350 T17348 pobj cells,by
R14124 T17461 T17455 conj for,for
R14125 T17351 T17354 punct ",",provide
R14126 T17352 T17353 poss our,data
R14127 T17462 T17461 pobj strategies,for
R14128 T17463 T17462 prep in,strategies
R14129 T17353 T17354 nsubj data,provide
R14130 T17464 T17463 pobj immunotherapy,in
R14131 T17354 T17354 ROOT provide,provide
R14132 T17355 T17356 det a,mechanism
R14133 T17465 T17462 prep in,strategies
R14134 T17356 T17354 dobj mechanism,provide
R14135 T17466 T17467 amod infectious,diseases
R14136 T17357 T17356 prep for,mechanism
R14137 T17467 T17465 pobj diseases,in
R14138 T17358 T17362 advmod how,induced
R14139 T17468 T17434 punct .,have
R14140 T17359 T17360 amod IL-10,expression
R14141 T17360 T17362 nsubjpass expression,induced
R14142 T17361 T17362 auxpass is,induced
R14143 T17362 T17357 pcomp induced,for
R14144 T17363 T17354 cc and,provide
R14145 T17364 T17365 advmod then,amplified
R14146 T17365 T17354 conj amplified,provide
R14147 T17366 T17365 cc and,amplified
R14148 T17367 T17365 conj regulated,amplified
R14149 T17368 T17367 agent by,regulated
R14150 T17369 T17370 det the,levels
R14151 T17370 T17368 pobj levels,by
R14152 T17371 T17370 prep of,levels
R14153 T17372 T17371 pobj antigen,of
R14154 T17373 T17372 cc and,antigen
R14155 T17374 T17372 conj IL-12,antigen
R14156 T17375 T17370 acl encountered,levels
R14157 T17376 T17375 prep in,encountered
R14158 T17377 T17378 det the,environment
R14159 T17378 T17376 pobj environment,in
R14160 T17379 T17354 punct .,provide
R14161 T17380 T17381 nsubj This,provides
R14162 T17381 T17381 ROOT provides,provides
R14163 T17382 T17383 det a,mechanism
R14164 T17383 T17381 dobj mechanism,provides
R14165 T17384 T17388 advmod whereby,responds
R14166 T17385 T17387 det a,cell
R14167 T17386 T17387 amod Th1,cell
R14168 T17387 T17388 nsubj cell,responds
R14169 T17388 T17383 relcl responds,mechanism
R14170 T17389 T17388 prep to,responds
R14171 T17390 T17391 amod extrinsic,signals
R14172 T17391 T17389 pobj signals,to
R14173 T17392 T17381 punct ",",provides
R14174 T17393 T17381 advcl reflecting,provides
R14175 T17394 T17395 amod increased,inflammation
R14176 T17395 T17393 dobj inflammation,reflecting
R14177 T17396 T17395 prep in,inflammation
R14178 T17397 T17398 det the,tissue
R14179 T17398 T17396 pobj tissue,in
R14808 T18710 T18722 nmod Mice,mice
R14809 T18711 T18710 punct ",",Mice
R14810 T18712 T18722 nmod Cytokines,mice
R14811 T18713 T18712 punct ",",Cytokines
R14812 T18714 T18712 conj Antibodies,Cytokines
R14813 T18715 T18714 punct ",",Antibodies
R14814 T18716 T18714 cc and,Antibodies
R14815 T18717 T18718 amod Other,Reagents
R14816 T18718 T18722 nmod Reagents,mice
R14817 T18719 T18720 compound BALB/c,DO11
R14818 T18720 T18718 appos DO11,Reagents
R14819 T18721 T18722 nummod .10,mice
R14820 T18722 T18722 ROOT mice,mice
R14821 T18723 T18735 amod transgenic,IL-4
R14822 T18724 T18723 prep for,transgenic
R14823 T18725 T18727 compound OVA-specific,WT
R14824 T18726 T18727 compound TCR,WT
R14825 T18727 T18724 pobj WT,for
R14826 T18728 T18723 cc or,transgenic
R14827 T18729 T18723 conj crossed,transgenic
R14828 T18730 T18729 advmod back,crossed
R14829 T18731 T18729 prep with,crossed
R14830 T18732 T18731 pobj Rag1,with
R14831 T18733 T18729 punct -,crossed
R14832 T18734 T18729 punct ",",crossed
R14833 T18735 T18722 dobj IL-4,mice
R14834 T18736 T18735 punct -,IL-4
R14835 T18737 T18735 punct ",",IL-4
R14836 T18738 T18748 dep IFN-γ,used
R14837 T18739 T18748 punct -,used
R14838 T18740 T18748 punct ",",used
R14839 T18741 T18748 nsubjpass STAT4,used
R14840 T18742 T18741 punct -,STAT4
R14841 T18743 T18742 punct ",",-
R14842 T18744 T18741 cc and,STAT4
R14843 T18745 T18746 amod STAT6-deficient,mice
R14844 T18746 T18741 conj mice,STAT4
R14845 T18747 T18748 auxpass were,used
R14846 T18748 T18748 ROOT used,used
R14847 T18749 T18748 prep as,used
R14848 T18750 T18751 det a,source
R14849 T18751 T18749 pobj source,as
R14850 T18752 T18751 prep of,source
R14851 T18753 T18755 amod antigen-specific,cells
R14852 T18754 T18755 compound T,cells
R14853 T18755 T18752 pobj cells,of
R14854 T18756 T18751 punct (,source
R14855 T18757 T18759 compound Murphy,al.
R14856 T18758 T18759 nmod et,al.
R14857 T18759 T18751 appos al.,source
R14858 T18760 T18759 punct ",",al.
R14859 T18761 T18759 appos 1990,al.
R14860 T18762 T18751 punct ;,source
R14861 T18763 T18765 compound Ouyang,al.
R14862 T18764 T18765 compound et,al.
R14864 T18766 T18765 punct ",",al.
R14865 T18767 T18765 npadvmod 1998,al.
R14866 T18768 T18765 punct ;,al.
R14867 T18769 T18771 compound Shoemaker,al.
R14868 T18770 T18771 compound et,al.
R14869 T18771 T18765 conj al.,al.
R14870 T18772 T18771 punct ",",al.
R14871 T18773 T18771 appos 2006,al.
R14872 T18774 T18771 punct ),al.
R14873 T18775 T18748 cc and,used
R14874 T18776 T18777 auxpass were,bred
R14875 T18777 T18748 conj bred,used
R14876 T18778 T18777 cc and,bred
R14877 T18779 T18777 conj maintained,bred
R14878 T18780 T18779 prep under,maintained
R14879 T18781 T18782 compound SPF,conditions
R14880 T18782 T18780 pobj conditions,under
R14881 T18783 T18779 prep at,maintained
R14882 T18784 T18785 det the,NIMR
R14883 T18785 T18783 pobj NIMR,at
R14884 T18786 T18785 punct ",",NIMR
R14885 T18787 T18785 conj London,NIMR
R14886 T18788 T18787 punct ",",London
R14887 T18789 T18790 compound Home,Office
R14888 T18790 T18787 conj Office,London
R14889 T18791 T18790 punct ",",Office
R14890 T18792 T18790 conj UK,Office
R14891 T18793 T18792 punct ",",UK
R14892 T18794 T18792 conj Animals,UK
R14893 T18795 T18797 punct (,Procedures
R14894 T18796 T18797 compound Scientific,Procedures
R14895 T18797 T18794 appos Procedures,Animals
R14896 T18798 T18797 punct ),Procedures
R14897 T18799 T18790 conj Act,Office
R14898 T18800 T18799 nummod 1986,Act
R14899 T18801 T18783 cc or,at
R14900 T18802 T18783 conj at,at
R14901 T18803 T18806 det the,School
R14902 T18804 T18805 compound Washington,University
R14903 T18805 T18806 compound University,School
R14904 T18806 T18802 pobj School,at
R14905 T18807 T18806 prep of,School
R14906 T18808 T18807 pobj Medicine,of
R14907 T18809 T18748 punct .,used
R14908 T18810 T18811 amod Female,mice
R14909 T18811 T18813 nsubjpass mice,used
R14910 T18812 T18813 auxpass were,used
R14911 T18813 T18813 ROOT used,used
R14912 T18814 T18813 prep at,used
R14913 T18815 T18814 pobj 8,at
R14914 T18816 T18817 nummod 12,weeks
R14915 T18817 T18818 npadvmod weeks,old
R14916 T18818 T18815 amod old,8
R14917 T18819 T18815 punct ",",8
R14918 T18820 T18815 cc and,8
R14919 T18821 T18822 compound animal,protocols
R14920 T18822 T18824 nsubjpass protocols,approved
R14921 T18823 T18824 auxpass were,approved
R14922 T18824 T18813 conj approved,used
R14923 T18825 T18824 xcomp according,approved
R14924 T18826 T18825 prep to,according
R14925 T18827 T18828 det the,Animals
R14926 T18828 T18826 pobj Animals,to
R14927 T18829 T18831 punct (,Procedures
R14928 T18830 T18831 compound Scientific,Procedures
R14929 T18831 T18828 appos Procedures,Animals
R14930 T18832 T18831 punct ),Procedures
R14931 T18833 T18824 conj Act,approved
R14932 T18834 T18833 nummod 1986,Act
R14933 T18835 T18833 punct ",",Act
R14934 T18836 T18837 compound Home,Office
R14935 T18837 T18833 conj Office,Act
R14936 T18838 T18837 punct ",",Office
R14937 T18839 T18837 conj UK,Office
R14938 T18840 T18824 punct .,approved
R14939 T18841 T18865 nsubjpass Reagents,described
R14940 T18842 T18841 punct ",",Reagents
R14941 T18843 T18841 prep including,Reagents
R14942 T18844 T18843 pobj antibodies,including
R14943 T18845 T18844 prep for,antibodies
R14944 T18846 T18847 compound T,cell
R14945 T18847 T18845 pobj cell,for
R14946 T18848 T18847 cc and,cell
R14947 T18849 T18850 compound DC,preparation
R14948 T18850 T18847 conj preparation,cell
R14949 T18851 T18850 punct ",",preparation
R14950 T18852 T18850 conj purification,preparation
R14951 T18853 T18852 cc and,purification
R14952 T18854 T18852 conj culture,purification
R14953 T18855 T18854 punct ",",culture
R14954 T18856 T18854 conj media,culture
R14955 T18857 T18856 punct ",",media
R14956 T18858 T18856 conj cytokines,media
R14957 T18859 T18858 punct ",",cytokines
R14958 T18860 T18858 cc and,cytokines
R14959 T18861 T18862 compound cytokine,mAbs
R14960 T18862 T18858 conj mAbs,cytokines
R14961 T18863 T18865 aux have,described
R14962 T18864 T18865 auxpass been,described
R14963 T18865 T18865 ROOT described,described
R14964 T18866 T18887 punct (,al.
R14965 T18867 T18869 compound Hosken,al.
R14966 T18868 T18869 nmod et,al.
R14967 T18869 T18887 ccomp al.,al.
R14968 T18870 T18869 punct ",",al.
R14969 T18871 T18869 npadvmod 1995,al.
R14970 T18872 T18887 punct ;,al.
R14971 T18873 T18875 compound Shoemaker,al.
R14972 T18874 T18875 compound et,al.
R14973 T18875 T18887 ccomp al.,al.
R14974 T18876 T18875 punct ",",al.
R14975 T18877 T18875 npadvmod 2006,al.
R14976 T18878 T18887 punct ;,al.
R14977 T18879 T18881 compound Veldhoen,al.
R14978 T18880 T18881 nmod et,al.
R14979 T18881 T18887 ccomp al.,al.
R14980 T18882 T18881 punct ",",al.
R14981 T18883 T18881 npadvmod 2009,al.
R14982 T18884 T18887 punct ;,al.
R14983 T18885 T18887 compound Veldhoen,al.
R14984 T18886 T18887 compound et,al.
R14985 T18887 T18865 parataxis al.,described
R14986 T18888 T18887 punct ",",al.
R14987 T18889 T18887 npadvmod 2006,al.
R14988 T18890 T18887 punct ),al.
R14989 T18891 T18865 punct .,described
R14990 T18892 T18897 nsubj LPS,was
R14991 T18893 T18895 punct (,minnesota
R14992 T18894 T18895 compound S.,minnesota
R14993 T18895 T18892 appos minnesota,LPS
R14994 T18896 T18895 punct ),minnesota
R14995 T18897 T18897 ROOT was,was
R14996 T18898 T18897 prep from,was
R14997 T18899 T18898 pobj Alexis,from
R14998 T18900 T18899 punct ",",Alexis
R14999 T18901 T18902 compound chicken,ovalbumin
R15000 T18902 T18903 compound ovalbumin,protein
R15001 T18903 T18897 attr protein,was
R15002 T18904 T18906 punct (,protein
R15003 T18905 T18906 compound OVA,protein
R15004 T18906 T18903 appos protein,protein
R15005 T18907 T18906 punct ),protein
R15006 T18908 T18897 conj was,was
R15007 T18909 T18908 prep from,was
R15008 T18910 T18909 prep from,from
R15009 T18911 T18910 pobj Sigma-Aldrich,from
R15010 T18912 T18909 punct ",",from
R15011 T18913 T18908 cc and,was
R15012 T18914 T18922 nsubj ovalbumin,was
R15013 T18915 T18914 appos peptide323-339,ovalbumin
R15014 T18916 T18917 punct (,OVA
R15015 T18917 T18915 appos OVA,peptide323-339
R15016 T18918 T18914 punct ),ovalbumin
R15017 T18919 T18920 punct (,endotoxin-free
R15018 T18920 T18914 appos endotoxin-free,ovalbumin
R15019 T18921 T18920 punct ),endotoxin-free
R15020 T18922 T18908 conj was,was
R15021 T18923 T18922 prep from,was
R15022 T18924 T18923 pobj Biosynthesis,from
R15023 T18925 T18922 punct .,was
R15024 T18926 T18927 nsubj U0126,was
R15025 T18927 T18927 ROOT was,was
R15026 T18928 T18927 prep from,was
R15027 T18929 T18930 compound BioMol,International
R15028 T18930 T18928 pobj International,from
R15029 T18931 T18927 punct .,was
R15030 T18932 T18950 nsubj PD184352,were
R15031 T18933 T18935 punct (,inhibitors
R15032 T18934 T18935 compound MEK,inhibitors
R15033 T18935 T18932 parataxis inhibitors,PD184352
R15034 T18936 T18935 punct ),inhibitors
R15035 T18937 T18935 punct ",",inhibitors
R15036 T18938 T18935 conj SB203580,inhibitors
R15037 T18939 T18938 punct (,SB203580
R15038 T18940 T18941 nummod p38,inhibitor
R15039 T18941 T18938 appos inhibitor,SB203580
R15040 T18942 T18938 punct ),SB203580
R15041 T18943 T18938 punct ",",SB203580
R15042 T18944 T18938 cc and,SB203580
R15043 T18945 T18938 conj CT99021,SB203580
R15044 T18946 T18948 punct (,inhibitor
R15045 T18947 T18948 compound GSK3β,inhibitor
R15046 T18948 T18945 appos inhibitor,CT99021
R15047 T18949 T18945 punct ),CT99021
R15048 T18950 T18950 ROOT were,were
R15049 T18951 T18952 compound kind,gifts
R15050 T18952 T18950 attr gifts,were
R15051 T18953 T18952 prep from,gifts
R15052 T18954 T18955 compound P.,Cohen
R15053 T18955 T18953 pobj Cohen,from
R15054 T18956 T18955 cc and,Cohen
R15055 T18957 T18958 compound N.,Shpiro
R15056 T18958 T18955 conj Shpiro,Cohen
R15057 T18959 T18958 punct ",",Shpiro
R15058 T18960 T18958 appos University,Shpiro
R15059 T18961 T18960 prep of,University
R15060 T18962 T18961 pobj Dundee,of
R15061 T18963 T18962 punct ",",Dundee
R15062 T18964 T18958 conj UK,Shpiro
R15063 T18965 T18950 punct .,were
R15415 T19460 T19481 nsubjpass Isolation,sorted
R15416 T19461 T19460 prep of,Isolation
R15417 T19462 T19465 nummod CD4,Cells
R15418 T19463 T19465 nummod +,Cells
R15419 T19464 T19465 compound T,Cells
R15420 T19465 T19461 pobj Cells,of
R15421 T19466 T19461 cc and,of
R15422 T19467 T19461 conj of,of
R15423 T19468 T19469 compound Splenic,DC
R15424 T19469 T19467 pobj DC,of
R15425 T19470 T19469 cc and,DC
R15426 T19471 T19472 compound Cell,Culture
R15427 T19472 T19469 conj Culture,DC
R15428 T19473 T19460 prep for,Isolation
R15429 T19474 T19477 compound T,Differentiation
R15430 T19475 T19477 compound Cell,Differentiation
R15431 T19476 T19477 compound Phenotype,Differentiation
R15432 T19477 T19478 compound Differentiation,T
R15433 T19478 T19479 compound T,cells
R15434 T19479 T19473 pobj cells,for
R15435 T19480 T19481 auxpass were,sorted
R15436 T19481 T19519 ccomp sorted,al.
R15437 T19482 T19481 prep for,sorted
R15438 T19483 T19485 compound CD4,CD62Lhi
R15439 T19484 T19485 compound +,CD62Lhi
R15440 T19485 T19482 pobj CD62Lhi,for
R15441 T19486 T19485 punct ",",CD62Lhi
R15442 T19487 T19490 compound CD4,−
R15443 T19488 T19490 compound +,−
R15444 T19489 T19490 compound CD62LhiCD25,−
R15445 T19490 T19485 conj −,CD62Lhi
R15446 T19491 T19490 punct ",",−
R15447 T19492 T19490 cc or,−
R15448 T19493 T19495 nummod CD4,CD44loCD25
R15449 T19494 T19495 compound +,CD44loCD25
R15450 T19495 T19490 conj CD44loCD25,−
R15451 T19496 T19481 conj −,sorted
R15452 T19497 T19498 aux to,>
R15453 T19498 T19496 xcomp >,−
R15454 T19499 T19500 nummod 98,%
R15455 T19500 T19498 npadvmod %,>
R15456 T19501 T19498 prep on,>
R15457 T19502 T19504 det a,cytometer
R15458 T19503 T19504 compound Moflo,cytometer
R15459 T19504 T19501 pobj cytometer,on
R15460 T19505 T19506 punct (,Cytomation
R15461 T19506 T19504 appos Cytomation,cytometer
R15462 T19507 T19498 punct ),>
R15463 T19508 T19496 prep as,−
R15464 T19509 T19508 prep before,as
R15465 T19510 T19513 punct (,al.
R15466 T19511 T19513 compound Shoemaker,al.
R15467 T19512 T19513 nmod et,al.
R15468 T19513 T19509 pobj al.,before
R15469 T19514 T19513 punct ",",al.
R15470 T19515 T19513 npadvmod 2006,al.
R15471 T19516 T19519 punct ;,al.
R15472 T19517 T19519 compound Veldhoen,al.
R15473 T19518 T19519 compound et,al.
R15474 T19519 T19519 ROOT al.,al.
R15475 T19520 T19519 punct ",",al.
R15476 T19521 T19519 npadvmod 2009,al.
R15477 T19522 T19519 punct ),al.
R15478 T19523 T19519 punct .,al.
R15479 T19524 T19530 prep In,reproduced
R15480 T19525 T19526 amod most,cases
R15481 T19526 T19524 pobj cases,In
R15482 T19527 T19530 punct ",",reproduced
R15483 T19528 T19530 nsubjpass experiments,reproduced
R15484 T19529 T19530 auxpass were,reproduced
R15485 T19530 T19530 ROOT reproduced,reproduced
R15486 T19531 T19530 prep with,reproduced
R15487 T19532 T19533 det each,type
R15488 T19533 T19531 pobj type,with
R15489 T19534 T19533 prep of,type
R15490 T19535 T19540 amod purified,population
R15491 T19536 T19540 nmod CD4,population
R15492 T19537 T19540 nummod +,population
R15493 T19538 T19540 compound T,population
R15494 T19539 T19540 compound cell,population
R15495 T19540 T19534 pobj population,of
R15496 T19541 T19540 prep with,population
R15497 T19542 T19543 amod similar,results
R15498 T19543 T19541 pobj results,with
R15499 T19544 T19543 acl obtained,results
R15500 T19545 T19530 punct .,reproduced
R15501 T19546 T19547 amod Splenic,DCs
R15502 T19547 T19549 nsubjpass DCs,prepared
R15503 T19548 T19549 auxpass were,prepared
R15504 T19549 T19549 ROOT prepared,prepared
R15505 T19550 T19551 mark as,described
R15506 T19551 T19549 advcl described,prepared
R15507 T19552 T19567 punct (,added
R15508 T19553 T19555 compound Hosken,al.
R15509 T19554 T19555 nmod et,al.
R15510 T19555 T19567 nsubjpass al.,added
R15511 T19556 T19555 punct ",",al.
R15512 T19557 T19555 npadvmod 1995,al.
R15513 T19558 T19555 punct ),al.
R15514 T19559 T19555 punct ",",al.
R15515 T19560 T19555 cc and,al.
R15516 T19561 T19562 nsubj sort,purified
R15517 T19562 T19555 conj purified,al.
R15518 T19563 T19565 amod CD11c,cells
R15519 T19564 T19565 compound +,cells
R15520 T19565 T19567 nsubjpass cells,added
R15521 T19566 T19567 auxpass were,added
R15522 T19567 T19549 parataxis added,prepared
R15523 T19568 T19567 prep to,added
R15524 T19569 T19572 det the,culture
R15525 T19570 T19572 compound T,culture
R15526 T19571 T19572 compound cell,culture
R15527 T19572 T19568 pobj culture,to
R15528 T19573 T19567 punct .,added
R15529 T19574 T19580 amod Purified,cells
R15530 T19575 T19580 nmod DO11,cells
R15531 T19576 T19580 nummod .10,cells
R15532 T19577 T19580 nmod CD4,cells
R15533 T19578 T19580 nummod +,cells
R15534 T19579 T19580 compound T,cells
R15535 T19580 T19588 nsubjpass cells,cultured
R15536 T19581 T19582 punct (,1
R15537 T19582 T19585 nummod 1,cells/ml
R15538 T19583 T19585 nummod ×,cells/ml
R15539 T19584 T19585 nummod 105,cells/ml
R15540 T19585 T19580 appos cells/ml,cells
R15541 T19586 T19580 punct ),cells
R15542 T19587 T19588 auxpass were,cultured
R15543 T19588 T19588 ROOT cultured,cultured
R15544 T19589 T19588 prep as,cultured
R15545 T19590 T19589 prep before,as
R15546 T19591 T19590 punct (,before
R15547 T19592 T19594 compound Hosken,al.
R15548 T19593 T19594 nmod et,al.
R15549 T19594 T19590 pobj al.,before
R15550 T19595 T19594 punct ",",al.
R15551 T19596 T19594 npadvmod 1995,al.
R15552 T19597 T19594 punct ),al.
R15553 T19598 T19613 punct ",",with
R15554 T19599 T19613 prep in,with
R15555 T19600 T19602 det a,volume
R15556 T19601 T19602 amod total,volume
R15557 T19602 T19599 pobj volume,in
R15558 T19603 T19602 prep of,volume
R15559 T19604 T19607 nummod 1,medium
R15560 T19605 T19607 compound ml,medium
R15561 T19606 T19607 compound cRPMI,medium
R15562 T19607 T19603 pobj medium,of
R15563 T19608 T19607 prep in,medium
R15564 T19609 T19611 det a,plate
R15565 T19610 T19611 amod 48-well,plate
R15566 T19611 T19608 pobj plate,in
R15567 T19612 T19599 punct ",",in
R15568 T19613 T19594 prep with,al.
R15569 T19614 T19615 compound splenic,DCs
R15570 T19615 T19613 pobj DCs,with
R15571 T19616 T19615 punct (,DCs
R15572 T19617 T19618 nummod 2,×
R15573 T19618 T19615 appos ×,DCs
R15574 T19619 T19620 nummod 104,cells/ml
R15575 T19620 T19618 appos cells/ml,×
R15576 T19621 T19620 punct ),cells/ml
R15577 T19622 T19618 punct ",",×
R15578 T19623 T19618 cc and,×
R15579 T19624 T19625 amod varying,amounts
R15580 T19625 T19618 conj amounts,×
R15581 T19626 T19625 prep of,amounts
R15582 T19627 T19626 pobj OVA,of
R15583 T19628 T19626 cc and,of
R15584 T19629 T19626 conj of,of
R15585 T19630 T19629 pobj IL-12,of
R15586 T19631 T19625 punct .,amounts
R15587 T19632 T19633 amod APC-independent,differentiation
R15588 T19633 T19645 nsubj differentiation,used
R15589 T19634 T19633 prep of,differentiation
R15590 T19635 T19639 amod naive,cells
R15591 T19636 T19639 compound CD4,cells
R15592 T19637 T19639 nummod +,cells
R15593 T19638 T19639 compound T,cells
R15594 T19639 T19634 pobj cells,of
R15595 T19640 T19633 prep into,differentiation
R15596 T19641 T19644 amod Th1,cells
R15597 T19642 T19641 cc and,Th1
R15598 T19643 T19641 conj Th2,Th1
R15599 T19644 T19640 pobj cells,into
R15600 T19645 T19645 ROOT used,used
R15601 T19646 T19645 dobj stimulation,used
R15602 T19647 T19645 prep with,used
R15603 T19648 T19654 amod anti-CD3,conditions
R15604 T19649 T19648 cc and,anti-CD3
R15605 T19650 T19648 conj anti-CD28,anti-CD3
R15606 T19651 T19650 cc and,anti-CD28
R15607 T19652 T19650 conj appropriate,anti-CD28
R15608 T19653 T19654 compound cytokine,conditions
R15609 T19654 T19647 pobj conditions,with
R15610 T19655 T19645 punct ",",used
R15611 T19656 T19645 cc and,used
R15612 T19657 T19661 compound control,cells
R15613 T19658 T19661 nmod Th1,cells
R15614 T19659 T19658 cc and,Th1
R15615 T19660 T19658 conj Th2,Th1
R15616 T19661 T19663 nsubjpass cells,cultured
R15617 T19662 T19663 auxpass were,cultured
R15618 T19663 T19645 conj cultured,used
R15619 T19664 T19665 mark as,described
R15620 T19665 T19663 advcl described,cultured
R15621 T19666 T19665 prep before,described
R15622 T19667 T19676 punct (,al.
R15623 T19668 T19670 compound Hosken,al.
R15624 T19669 T19670 nmod et,al.
R15625 T19670 T19676 ccomp al.,al.
R15626 T19671 T19670 punct ",",al.
R15627 T19672 T19670 npadvmod 1995,al.
R15628 T19673 T19676 punct ;,al.
R15629 T19674 T19676 compound Shoemaker,al.
R15630 T19675 T19676 compound et,al.
R15631 T19676 T19666 pobj al.,before
R15632 T19677 T19676 punct ",",al.
R15633 T19678 T19676 npadvmod 2006,al.
R15634 T19679 T19676 punct ),al.
R15635 T19680 T19663 punct .,cultured
R15636 T19681 T19682 compound Culture,conditions
R15637 T19682 T19686 nsubj conditions,were
R15638 T19683 T19682 prep for,conditions
R15639 T19684 T19685 compound Th17,cells
R15640 T19685 T19683 pobj cells,for
R15641 T19686 T19686 ROOT were,were
R15642 T19687 T19688 mark as,described
R15643 T19688 T19686 advcl described,were
R15644 T19689 T19688 prep before,described
R15645 T19690 T19693 punct (,al.
R15646 T19691 T19693 compound Veldhoen,al.
R15647 T19692 T19693 nmod et,al.
R15648 T19693 T19689 pobj al.,before
R15649 T19694 T19693 punct ",",al.
R15650 T19695 T19693 npadvmod 2006,al.
R15651 T19696 T19693 punct ),al.
R15652 T19697 T19686 punct .,were
R15653 T19698 T19706 advmod Importantly,differentiated
R15654 T19699 T19706 punct ",",differentiated
R15655 T19700 T19703 nmod Th1,cells
R15656 T19701 T19700 cc and,Th1
R15657 T19702 T19700 conj Th2,Th1
R15658 T19703 T19706 nsubjpass cells,differentiated
R15659 T19704 T19706 aux could,differentiated
R15660 T19705 T19706 auxpass be,differentiated
R15661 T19706 T19706 ROOT differentiated,differentiated
R15662 T19707 T19706 prep in,differentiated
R15663 T19708 T19707 pobj cRPMI,in
R15664 T19709 T19708 cc or,cRPMI
R15665 T19710 T19708 conj IMDM,cRPMI
R15666 T19711 T19714 punct (,al.
R15667 T19712 T19714 nmod Hosken,al.
R15668 T19713 T19714 nmod et,al.
R15669 T19714 T19736 ccomp al.,differentiated
R15670 T19715 T19714 punct ",",al.
R15671 T19716 T19714 npadvmod 1995,al.
R15672 T19717 T19714 punct ;,al.
R15673 T19718 T19720 compound Shoemaker,al.
R15674 T19719 T19720 compound et,al.
R15675 T19720 T19736 ccomp al.,differentiated
R15676 T19721 T19720 punct ",",al.
R15677 T19722 T19720 appos 2006,al.
R15678 T19723 T19736 punct ;,differentiated
R15679 T19724 T19726 compound Veldhoen,al.
R15680 T19725 T19726 compound et,al.
R15681 T19726 T19736 nsubjpass al.,differentiated
R15682 T19727 T19726 punct ",",al.
R15683 T19728 T19726 npadvmod 2006,al.
R15684 T19729 T19726 punct ),al.
R15685 T19730 T19726 punct ",",al.
R15686 T19731 T19726 cc but,al.
R15687 T19732 T19733 compound Th17,cells
R15688 T19733 T19734 nsubj cells,were
R15689 T19734 T19736 auxpass were,differentiated
R15690 T19735 T19736 advmod only,differentiated
R15691 T19736 T19736 ROOT differentiated,differentiated
R15692 T19737 T19736 advmod optimally,differentiated
R15693 T19738 T19736 prep in,differentiated
R15694 T19739 T19738 pobj IMDM,in
R15695 T19740 T19739 punct (,IMDM
R15696 T19741 T19743 compound Veldhoen,al.
R15697 T19742 T19743 nmod et,al.
R15698 T19743 T19736 punct al.,differentiated
R15699 T19744 T19743 punct ",",al.
R15700 T19745 T19743 npadvmod 2009,al.
R15701 T19746 T19736 punct ),differentiated
R15702 T19747 T19706 punct .,differentiated
R15703 T19748 T19749 advmod When,indicated
R15704 T19749 T19777 advcl indicated,were
R15705 T19750 T19749 punct ",",indicated
R15706 T19751 T19777 nsubj U0126,were
R15707 T19752 T19751 cc or,U0126
R15708 T19753 T19751 conj PD184352,U0126
R15709 T19754 T19753 punct (,PD184352
R15710 T19755 T19756 compound MEK,inhibitors
R15711 T19756 T19753 appos inhibitors,PD184352
R15712 T19757 T19753 punct ),PD184352
R15713 T19758 T19753 punct ",",PD184352
R15714 T19759 T19753 conj SB203580,PD184352
R15715 T19760 T19759 punct (,SB203580
R15716 T19761 T19762 nummod p38,inhibitor
R15717 T19762 T19759 appos inhibitor,SB203580
R15718 T19763 T19759 punct ),SB203580
R15719 T19764 T19759 punct ",",SB203580
R15720 T19765 T19759 conj CT99021,SB203580
R15721 T19766 T19768 punct (,inhibitor
R15722 T19767 T19768 compound GSK3β,inhibitor
R15723 T19768 T19765 appos inhibitor,CT99021
R15724 T19769 T19765 punct ),CT99021
R15725 T19770 T19765 punct ",",CT99021
R15726 T19771 T19759 cc or,SB203580
R15727 T19772 T19774 det a,amount
R15728 T19773 T19774 amod similar,amount
R15729 T19774 T19751 appos amount,U0126
R15730 T19775 T19774 prep of,amount
R15731 T19776 T19775 pobj DMSO,of
R15732 T19777 T19777 ROOT were,were
R15733 T19778 T19777 acomp present,were
R15734 T19779 T19778 prep in,present
R15735 T19780 T19781 det the,culture
R15736 T19781 T19779 pobj culture,in
R15737 T19782 T19777 punct .,were
R15738 T19783 T19784 amod More,details
R15739 T19784 T19790 nsubjpass details,provided
R15740 T19785 T19784 prep of,details
R15741 T19786 T19788 amod specific,conditions
R15742 T19787 T19788 compound culture,conditions
R15743 T19788 T19785 pobj conditions,of
R15744 T19789 T19790 auxpass are,provided
R15745 T19790 T19790 ROOT provided,provided
R15746 T19791 T19790 prep in,provided
R15747 T19792 T19793 compound Figures,S6
R15748 T19793 T19791 pobj S6,in
R15749 T19794 T19793 cc and,S6
R15750 T19795 T19793 conj S7,S6
R15751 T19796 T19790 punct .,provided
R15885 T20063 T20064 compound Cytokine,Detection
R15886 T20064 T20064 ROOT Detection,Detection
R15887 T20065 T20064 prep by,Detection
R15888 T20066 T20065 pobj ICS,by
R15889 T20067 T20066 cc and,ICS
R15890 T20068 T20066 conj ELISA,ICS
R15891 T20069 T20077 prep At,restimulated
R15892 T20070 T20069 pobj day,At
R15893 T20071 T20070 nummod 5,day
R15894 T20072 T20071 cc or,5
R15895 T20073 T20071 conj 7,5
R15896 T20074 T20077 punct ",",restimulated
R15897 T20075 T20077 nsubjpass cells,restimulated
R15898 T20076 T20077 auxpass were,restimulated
R15899 T20077 T20077 ROOT restimulated,restimulated
R15900 T20078 T20077 prep with,restimulated
R15901 T20079 T20080 amod immobilized,anti-CD3
R15902 T20080 T20105 amod anti-CD3,]
R15903 T20081 T20085 punct (,ml
R15904 T20082 T20083 nummod 2,μg
R15905 T20083 T20085 nmod μg,ml
R15906 T20084 T20085 compound /,ml
R15907 T20085 T20080 appos ml,anti-CD3
R15908 T20086 T20085 punct ),ml
R15909 T20087 T20080 cc and,anti-CD3
R15910 T20088 T20080 conj anti-CD28,anti-CD3
R15911 T20089 T20093 punct (,ml
R15912 T20090 T20091 nummod 2,μg
R15913 T20091 T20093 nmod μg,ml
R15914 T20092 T20093 compound /,ml
R15915 T20093 T20088 appos ml,anti-CD28
R15916 T20094 T20093 punct ),ml
R15917 T20095 T20097 punct (,hr
R15918 T20096 T20097 nummod 4,hr
R15919 T20097 T20105 nmod hr,]
R15920 T20098 T20097 prep with,hr
R15921 T20099 T20100 compound BrefeldinA,[
R15922 T20100 T20098 pobj [,with
R15923 T20101 T20102 nummod 10,μg
R15924 T20102 T20105 compound μg,]
R15925 T20103 T20104 compound /,ml
R15926 T20104 T20105 compound ml,]
R15927 T20105 T20078 pobj ],with
R15928 T20106 T20077 prep in,restimulated
R15929 T20107 T20110 det the,hr
R15930 T20108 T20110 amod last,hr
R15931 T20109 T20110 nummod 2,hr
R15932 T20110 T20106 pobj hr,in
R15933 T20111 T20077 punct ),restimulated
R15934 T20112 T20077 cc or,restimulated
R15935 T20113 T20077 conj with,restimulated
R15936 T20114 T20113 pobj PdBU,with
R15937 T20115 T20114 cc and,PdBU
R15938 T20116 T20114 conj Ionomycin,PdBU
R15939 T20117 T20119 punct (,hr
R15940 T20118 T20119 nummod 5,hr
R15941 T20119 T20116 appos hr,Ionomycin
R15942 T20120 T20119 prep with,hr
R15943 T20121 T20122 compound BrefeldinA,[
R15944 T20122 T20120 pobj [,with
R15945 T20123 T20124 nummod 1,μg
R15946 T20124 T20127 compound μg,]
R15947 T20125 T20127 compound /,]
R15948 T20126 T20127 compound ml,]
R15949 T20127 T20122 appos ],[
R15950 T20128 T20122 punct ),[
R15951 T20129 T20077 punct .,restimulated
R15952 T20130 T20136 prep After,collected
R15953 T20131 T20132 compound ICS,FACS
R15954 T20132 T20130 pobj FACS,After
R15955 T20133 T20136 punct ",",collected
R15956 T20134 T20136 nsubjpass data,collected
R15957 T20135 T20136 auxpass were,collected
R15958 T20136 T20136 ROOT collected,collected
R15959 T20137 T20136 prep on,collected
R15960 T20138 T20139 det a,FACSCalibur
R15961 T20139 T20137 pobj FACSCalibur,on
R15962 T20140 T20139 punct (,FACSCalibur
R15963 T20141 T20142 compound Becton,Dickinson
R15964 T20142 T20139 appos Dickinson,FACSCalibur
R15965 T20143 T20139 punct ),FACSCalibur
R15966 T20144 T20136 cc and,collected
R15967 T20145 T20136 conj analyzed,collected
R15968 T20146 T20145 prep with,analyzed
R15969 T20147 T20146 pobj FlowJo,with
R15970 T20148 T20147 punct (,FlowJo
R15971 T20149 T20150 compound Tree,Star
R15972 T20150 T20147 appos Star,FlowJo
R15973 T20151 T20147 punct ),FlowJo
R15974 T20152 T20136 punct .,collected
R15975 T20153 T20159 prep For,restimulated
R15976 T20154 T20153 pobj ELISA,For
R15977 T20155 T20159 punct ",",restimulated
R15978 T20156 T20159 nsubjpass cells,restimulated
R15979 T20157 T20159 auxpass were,restimulated
R15980 T20158 T20159 advmod similarly,restimulated
R15981 T20159 T20159 ROOT restimulated,restimulated
R15982 T20160 T20159 prep for,restimulated
R15983 T20161 T20166 nummod 48,collected
R15984 T20162 T20166 nsubjpass hr,collected
R15985 T20163 T20162 cc and,hr
R15986 T20164 T20162 conj supernatant,hr
R15987 T20165 T20166 auxpass was,collected
R15988 T20166 T20159 conj collected,restimulated
R15989 T20167 T20166 cc and,collected
R15990 T20168 T20166 conj analyzed,collected
R15991 T20169 T20168 prep for,analyzed
R15992 T20170 T20169 pobj IL-4,for
R15993 T20171 T20170 punct ",",IL-4
R15994 T20172 T20170 conj IL-10,IL-4
R15995 T20173 T20172 punct ",",IL-10
R15996 T20174 T20172 cc and,IL-10
R15997 T20175 T20172 conj IFN-γ,IL-10
R15998 T20176 T20177 mark as,described
R15999 T20177 T20168 advcl described,analyzed
R16000 T20178 T20177 prep before,described
R16001 T20179 T20182 punct (,al.
R16002 T20180 T20182 compound Shoemaker,al.
R16003 T20181 T20182 nmod et,al.
R16004 T20182 T20178 pobj al.,before
R16005 T20183 T20182 punct ",",al.
R16006 T20184 T20182 npadvmod 2006,al.
R16007 T20185 T20182 punct ),al.
R16008 T20186 T20159 punct .,restimulated
R16172 T20407 T20413 prep In,injected
R16173 T20408 T20410 compound Vivo,BALB/c
R16174 T20409 T20410 compound Studies,BALB/c
R16175 T20410 T20411 compound BALB/c,mice
R16176 T20411 T20413 nsubjpass mice,injected
R16177 T20412 T20413 auxpass were,injected
R16178 T20413 T20413 ROOT injected,injected
R16179 T20414 T20413 advmod intravenously,injected
R16180 T20415 T20413 punct (,injected
R16181 T20416 T20413 parataxis i.v.,injected
R16182 T20417 T20416 punct ),i.v.
R16183 T20418 T20413 prep with,injected
R16184 T20419 T20421 det a,blood
R16185 T20420 T20421 amod red,blood
R16186 T20421 T20418 pobj blood,with
R16187 T20422 T20425 amod cell-depleted,suspension
R16188 T20423 T20425 amod single-cell,suspension
R16189 T20424 T20425 compound spleen,suspension
R16190 T20425 T20421 appos suspension,blood
R16191 T20426 T20425 punct (,suspension
R16192 T20427 T20428 nummod 2.5,×
R16193 T20428 T20425 appos ×,suspension
R16194 T20429 T20430 nummod 107,cells
R16195 T20430 T20428 appos cells,×
R16196 T20431 T20421 punct ),blood
R16197 T20432 T20435 punct (,al.
R16198 T20433 T20435 compound Castro,al.
R16199 T20434 T20435 nmod et,al.
R16200 T20435 T20413 punct al.,injected
R16201 T20436 T20435 punct ",",al.
R16202 T20437 T20435 appos 2000,al.
R16203 T20438 T20435 punct ),al.
R16204 T20439 T20413 prep from,injected
R16205 T20440 T20442 nummod DO11,WT
R16206 T20441 T20442 nummod .10,WT
R16207 T20442 T20439 pobj WT,from
R16208 T20443 T20442 cc or,WT
R16209 T20444 T20445 amod STAT-deficient,mice
R16210 T20445 T20442 conj mice,WT
R16211 T20446 T20413 punct .,injected
R16212 T20447 T20453 prep After,injected
R16213 T20448 T20449 nummod 48,hr
R16214 T20449 T20447 pobj hr,After
R16215 T20450 T20453 punct ",",injected
R16216 T20451 T20453 nsubjpass they,injected
R16217 T20452 T20453 auxpass were,injected
R16218 T20453 T20453 ROOT injected,injected
R16219 T20454 T20453 advmod subcutaneously,injected
R16220 T20455 T20453 prep with,injected
R16221 T20456 T20455 pobj PBS,with
R16222 T20457 T20455 cc or,with
R16223 T20458 T20455 conj with,with
R16224 T20459 T20460 compound OVA,protein
R16225 T20460 T20458 pobj protein,with
R16226 T20461 T20460 punct (,protein
R16227 T20462 T20463 nummod 5,mg
R16228 T20463 T20460 appos mg,protein
R16229 T20464 T20460 punct ),protein
R16230 T20465 T20460 cc plus,protein
R16231 T20466 T20460 conj LPS,protein
R16232 T20467 T20469 punct (,μg
R16233 T20468 T20469 nummod 5,μg
R16234 T20469 T20466 appos μg,LPS
R16235 T20470 T20469 punct ),μg
R16236 T20471 T20453 punct .,injected
R16237 T20472 T20475 det The,nodes
R16238 T20473 T20475 amod inguinal,nodes
R16239 T20474 T20475 compound lymph,nodes
R16240 T20475 T20477 nsubjpass nodes,removed
R16241 T20476 T20477 auxpass were,removed
R16242 T20477 T20477 ROOT removed,removed
R16243 T20478 T20479 nummod 48,hr
R16244 T20479 T20480 npadvmod hr,later
R16245 T20480 T20477 advmod later,removed
R16246 T20481 T20477 punct .,removed
R16247 T20482 T20484 det A,suspension
R16248 T20483 T20484 amod single-cell,suspension
R16249 T20484 T20492 nsubjpass suspension,restimulated
R16250 T20485 T20486 punct (,1
R16251 T20486 T20489 nummod 1,cells
R16252 T20487 T20489 nummod ×,cells
R16253 T20488 T20489 nummod 106,cells
R16254 T20489 T20484 appos cells,suspension
R16255 T20490 T20484 punct ),suspension
R16256 T20491 T20492 auxpass was,restimulated
R16257 T20492 T20492 ROOT restimulated,restimulated
R16258 T20493 T20492 prep for,restimulated
R16259 T20494 T20497 nummod 24,hr
R16260 T20495 T20494 cc or,24
R16261 T20496 T20494 conj 48,24
R16262 T20497 T20493 pobj hr,for
R16263 T20498 T20492 prep with,restimulated
R16301 T20536 T20536 ROOT fixed,fixed
R16302 T20537 T20536 cc and,fixed
R16303 T20538 T20536 conj stained,fixed
R16304 T20539 T20538 prep as,stained
R16305 T20540 T20539 pcomp before,as
R16306 T20541 T20536 punct .,fixed
R16307 T20542 T20549 nsubj Those,were
R16308 T20543 T20542 amod positive,Those
R16309 T20544 T20543 prep for,positive
R16310 T20545 T20544 pobj KJ1-26-Bio,for
R16311 T20546 T20544 cc and,for
R16312 T20547 T20544 conj for,for
R16313 T20548 T20547 pobj CD4-PerCP,for
R16314 T20549 T20549 ROOT were,were
R16315 T20550 T20549 acomp gated,were
R16316 T20551 T20549 punct ",",were
R16317 T20552 T20549 cc and,were
R16318 T20553 T20558 nsubjpass IFN-γ,examined
R16319 T20554 T20553 cc and,IFN-γ
R16320 T20555 T20553 conj IL-10,IFN-γ
R16321 T20556 T20553 conj staining,IFN-γ
R16322 T20557 T20558 auxpass was,examined
R16323 T20558 T20549 conj examined,were
R16324 T20559 T20558 prep for,examined
R16325 T20560 T20561 det this,population
R16326 T20561 T20559 pobj population,for
R16327 T20562 T20558 cc and,examined
R16328 T20563 T20558 conj analyzed,examined
R16329 T20564 T20563 prep as,analyzed
R16330 T20565 T20564 pcomp before,as
R16331 T20566 T20558 punct .,examined
R16437 T20730 T20733 amod Real-Time,Cells
R16438 T20731 T20733 compound Quantitative,Cells
R16439 T20732 T20733 compound RT-PCR,Cells
R16440 T20733 T20735 nsubjpass Cells,harvested
R16441 T20734 T20735 auxpass were,harvested
R16442 T20735 T20735 ROOT harvested,harvested
R16443 T20736 T20735 cc and,harvested
R16444 T20737 T20735 conj restimulated,harvested
R16445 T20738 T20737 prep in,restimulated
R16446 T20739 T20740 det the,presence
R16447 T20740 T20738 pobj presence,in
R16448 T20741 T20740 prep of,presence
R16449 T20742 T20743 amod immobilized,anti-CD3
R16450 T20743 T20741 pobj anti-CD3,of
R16451 T20744 T20743 punct (,anti-CD3
R16452 T20745 T20746 nummod 2,μg
R16453 T20746 T20748 nmod μg,ml
R16454 T20747 T20748 compound /,ml
R16455 T20748 T20743 appos ml,anti-CD3
R16456 T20749 T20748 punct ),ml
R16457 T20750 T20743 cc plus,anti-CD3
R16458 T20751 T20743 conj anti-CD28,anti-CD3
R16459 T20752 T20756 punct (,ml
R16460 T20753 T20754 nummod 2,μg
R16461 T20754 T20756 nmod μg,ml
R16462 T20755 T20756 compound /,ml
R16463 T20756 T20751 appos ml,anti-CD28
R16464 T20757 T20737 punct ),restimulated
R16465 T20758 T20737 prep for,restimulated
R16466 T20759 T20760 nummod 3,hr
R16468 T20761 T20760 cc or,hr
R16469 T20762 T20763 advmod immediately,lysed
R16470 T20763 T20735 conj lysed,harvested
R16471 T20764 T20735 punct .,harvested
R16472 T20765 T20767 nsubjpass RNA,extracted
R16473 T20766 T20767 auxpass was,extracted
R16474 T20767 T20767 ROOT extracted,extracted
R16475 T20768 T20767 cc and,extracted
R16476 T20769 T20767 conj reverse-transcribed,extracted
R16477 T20770 T20769 cc and,reverse-transcribed
R16478 T20771 T20769 conj cDNA,reverse-transcribed
R16479 T20772 T20773 auxpass was,analyzed
R16480 T20773 T20767 conj analyzed,extracted
R16481 T20774 T20773 prep for,analyzed
R16482 T20775 T20776 det the,expression
R16483 T20776 T20774 pobj expression,for
R16484 T20777 T20776 prep of,expression
R16485 T20778 T20777 pobj cytokines,of
R16486 T20779 T20778 cc and,cytokines
R16487 T20780 T20781 compound transcription,factors
R16488 T20781 T20778 conj factors,cytokines
R16489 T20782 T20776 prep by,expression
R16490 T20783 T20785 amod real-time,assay
R16491 T20784 T20785 compound PCR,assay
R16492 T20785 T20782 pobj assay,by
R16493 T20786 T20773 prep as,analyzed
R16494 T20787 T20786 prep before,as
R16495 T20788 T20791 punct (,al.
R16496 T20789 T20791 compound Shoemaker,al.
R16497 T20790 T20791 nmod et,al.
R16498 T20791 T20787 pobj al.,before
R16499 T20792 T20791 punct ",",al.
R16500 T20793 T20791 npadvmod 2006,al.
R16501 T20794 T20791 punct ),al.
R16502 T20795 T20767 punct .,extracted
R16503 T20796 T20797 compound Target,gene
R16504 T20797 T20799 compound gene,expression
R16505 T20798 T20799 compound mRNA,expression
R16506 T20799 T20801 nsubjpass expression,quantified
R16507 T20800 T20801 auxpass was,quantified
R16508 T20801 T20801 ROOT quantified,quantified
R16509 T20802 T20801 advmod either,quantified
R16510 T20803 T20801 prep with,quantified
R16511 T20804 T20805 compound SYBR,Green
R16512 T20805 T20803 pobj Green,with
R16513 T20806 T20808 punct (,Biosystems
R16514 T20807 T20808 compound Applied,Biosystems
R16515 T20808 T20805 parataxis Biosystems,Green
R16516 T20809 T20808 punct ),Biosystems
R16517 T20810 T20803 cc or,with
R16518 T20811 T20803 conj with,with
R16519 T20812 T20813 compound Master,Mix
R16520 T20813 T20811 pobj Mix,with
R16521 T20814 T20813 punct (,Mix
R16522 T20815 T20816 compound Applied,Biosystems
R16523 T20816 T20813 appos Biosystems,Mix
R16524 T20817 T20816 punct ),Biosystems
R16525 T20818 T20811 cc and,with
R16526 T20819 T20811 conj normalized,with
R16527 T20820 T20821 aux to,ubiquitin
R16628 T20955 T20959 nsubjpass amounts,separated
R16629 T20956 T20955 prep of,amounts
R16630 T20957 T20956 pobj protein,of
R16631 T20958 T20959 auxpass were,separated
R16632 T20959 T20952 ccomp separated,prepared
R16633 T20960 T20959 agent by,separated
R16634 T20961 T20960 pobj SDS-PAGE,by
R16635 T20962 T20959 punct ",",separated
R16636 T20963 T20959 cc and,separated
R16637 T20964 T20959 conj phosphorylated,separated
R16638 T20965 T20964 cc or,phosphorylated
R16639 T20966 T20964 conj total,phosphorylated
R16640 T20967 T20971 nsubjpass ERK,detected
R16641 T20968 T20967 cc and,ERK
R16642 T20969 T20967 conj actin,ERK
R16643 T20970 T20971 auxpass were,detected
R16644 T20971 T20951 conj detected,were
R16645 T20972 T20973 mark as,described
R16646 T20973 T20971 advcl described,detected
R16647 T20974 T20973 prep before,described
R16648 T20975 T20978 punct (,al.
R16649 T20976 T20978 nmod Beinke,al.
R16650 T20977 T20978 nmod et,al.
R16651 T20978 T20974 pobj al.,before
R16652 T20979 T20978 punct ",",al.
R16653 T20980 T20978 npadvmod 2004,al.
R16654 T20981 T20978 punct ),al.
R16655 T20982 T20971 punct .,detected
R8031 T10311 T10309 appos CT99021,inhibitor
R8032 T10312 T10315 punct (,al.
R8033 T10313 T10315 compound Bain,al.
R8034 T10314 T10315 nmod et,al.
R5649 T7379 T7377 pobj immunization,in
R7716 T9996 T9997 compound antigen,doses
R7717 T9997 T9990 pobj doses,with
R7718 T9998 T10000 punct (,5A
R7719 T9999 T10000 compound Figure,5A
R7720 T10000 T9997 appos 5A,doses
R7721 T10001 T10000 punct ),5A
R7722 T10002 T9945 punct .,induced
R7723 T10003 T10014 mark Although,varied
R7724 T10004 T10006 det the,peak
R7725 T10005 T10006 amod apparent,peak
R7726 T10006 T10014 nsubj peak,varied
R7727 T10007 T10006 cc and,peak
R7728 T10008 T10006 conj amount,peak
R7729 T10009 T10008 prep of,amount
R7730 T10010 T10009 pobj ERK1,of
R7731 T10011 T10010 cc and,ERK1
R7732 T10012 T10010 conj ERK2,ERK1
R7733 T10013 T10008 conj activation,amount
R7734 T10014 T10022 advcl varied,was
R7735 T10015 T10014 advmod slightly,varied
R7736 T10016 T10014 prep between,varied
R7737 T10017 T10016 pobj experiments,between
R7738 T10018 T10022 punct ",",was
R7739 T10019 T10021 det a,finding
R7740 T10020 T10021 amod consistent,finding
R7741 T10021 T10022 nsubj finding,was
R7742 T10022 T10022 ROOT was,was
R7743 T10023 T10026 det that,dose
R7844 T10124 T10123 prep of,presence
R7845 T10125 T10126 amod increasing,doses
R7846 T10126 T10124 pobj doses,of
R7847 T10127 T10126 prep of,doses
R7848 T10128 T10127 pobj anti-CD3,of
R7849 T10129 T10128 cc and,anti-CD3
R7850 T10130 T10132 det a,amount
R7851 T10131 T10132 amod constant,amount
R7852 T10132 T10128 conj amount,anti-CD3
R7853 T10133 T10132 prep of,amount
R7854 T10134 T10133 pobj IL-12,of
R7855 T10135 T10110 punct .,used
R7856 T10136 T10148 prep As,led
R7857 T10137 T10136 prep in,As
R7858 T10138 T10140 det the,cultures
R7859 T10139 T10140 amod APC-driven,cultures
R7860 T10140 T10137 pobj cultures,in
R7861 T10141 T10140 punct ",",cultures
R7862 T10142 T10144 amod stronger,stimulation
R7863 T10143 T10144 compound TCR,stimulation
R8035 T10315 T10309 parataxis al.,inhibitor
R8036 T10316 T10315 punct ",",al.
R8037 T10317 T10315 npadvmod 2007,al.
R8038 T10318 T10315 punct ),al.
R8039 T10319 T10309 punct ",",inhibitor
R8040 T10320 T10321 det no,effect
R8041 T10321 T10326 nsubjpass effect,observed
R8042 T10322 T10321 prep on,effect
R8043 T10323 T10324 compound IL-10,production
R8044 T10324 T10322 pobj production,on
R8045 T10325 T10326 auxpass was,observed
R8046 T10326 T10326 ROOT observed,observed
R8047 T10327 T10328 punct (,Figure
R8048 T10328 T10326 oprd Figure,observed
R8049 T10329 T10328 nummod S5B,Figure
R8050 T10330 T10328 punct ),Figure
R8051 T10331 T10326 punct .,observed
R8052 T10332 T10333 poss Our,data
R8053 T10333 T10335 nsubj data,suggested
R8054 T10334 T10335 advmod thus,suggested
R8055 T10335 T10335 ROOT suggested,suggested
R8056 T10336 T10350 mark that,requires
R8057 T10337 T10338 amod IL-10,production
R8058 T10338 T10350 nsubj production,requires
R8059 T10339 T10338 prep by,production
R8060 T10340 T10341 amod Th1,cells
R8061 T10341 T10339 pobj cells,by
R8062 T10342 T10338 prep in,production
R8063 T10343 T10342 pobj response,in
R8064 T10344 T10343 prep to,response
R8065 T10345 T10347 amod high,dose
R8066 T10346 T10347 compound antigen,dose
R8067 T10347 T10344 pobj dose,to
R8068 T10348 T10347 cc and,dose
R8069 T10349 T10350 nsubj IL-12,requires
R8717 T11275 T11277 compound Veldhoen,al.
R8718 T11276 T11277 compound et,al.
R8719 T11277 T11259 pobj al.,with
R8720 T11278 T11277 punct ",",al.
R8721 T11279 T11277 appos 2009,al.
R8722 T11280 T11277 punct ;,al.
R8723 T11281 T11283 compound Veldhoen,al.
R8724 T11282 T11283 compound et,al.
R8725 T11283 T11277 conj al.,al.
R8731 T11289 T11290 det the,presence
R8726 T11284 T11283 punct ",",al.
R8727 T11285 T11283 npadvmod 2006,al.
R8728 T11286 T11256 punct ),differentiated
R8729 T11287 T11256 punct ",",differentiated
R8730 T11288 T11256 prep in,differentiated
R10260 T13057 T13055 acomp affected,was
R10261 T13058 T13060 punct (,6D
R10262 T13059 T13060 compound Figure,6D
R10263 T13060 T13055 parataxis 6D,was
R10264 T13061 T13060 punct ),6D
R10265 T13062 T13021 punct .,showed
R12746 T16035 T16032 conj infections,inflammation
R14863 T18765 T18751 conj al.,source
R16264 T20499 T20503 nummod 1,μM
R16265 T20500 T20499 quantmod μM,1
R16266 T20501 T20499 cc or,1
R16267 T20502 T20503 nummod 3,μM
R16268 T20503 T20498 pobj μM,with
R16269 T20504 T20503 prep of,μM
R16270 T20505 T20504 pobj OVA,of
R16271 T20506 T20498 cc and,with
R16272 T20507 T20498 conj with,with
R16273 T20508 T20507 pobj BrefeldinA,with
R16274 T20509 T20492 prep for,restimulated
R16275 T20510 T20513 det the,hr
R16276 T20511 T20513 amod last,hr
R16277 T20512 T20513 nummod 6,hr
R16278 T20513 T20509 pobj hr,for
R16279 T20514 T20492 punct .,restimulated
R16280 T20515 T20520 nsubjpass Half,removed
R16281 T20516 T20515 prep of,Half
R16282 T20517 T20518 det the,supernatant
R16283 T20518 T20516 pobj supernatant,of
R16284 T20519 T20520 auxpass was,removed
R16285 T20520 T20520 ROOT removed,removed
R16286 T20521 T20520 prep before,removed
R16287 T20522 T20523 det the,addition
R16288 T20523 T20521 pobj addition,before
R16289 T20524 T20523 prep of,addition
R16290 T20525 T20524 pobj BrefeldinA,of
R16291 T20526 T20523 prep for,addition
R16292 T20527 T20526 pobj use,for
R16293 T20528 T20527 prep in,use
R16294 T20529 T20531 det an,assay
R16295 T20530 T20531 compound ELISA,assay
R16296 T20531 T20528 pobj assay,in
R16297 T20532 T20520 punct .,removed
R16298 T20533 T20534 det The,cells
R16299 T20534 T20536 nsubjpass cells,fixed
R16300 T20535 T20536 auxpass were,fixed
R16467 T20760 T20758 pobj hr,for
R16528 T20821 T20819 advcl ubiquitin,normalized
R16529 T20822 T20819 cc or,normalized
R16530 T20823 T20825 compound HPRT,levels
R16531 T20824 T20825 compound mRNA,levels
R16532 T20825 T20819 conj levels,normalized
R16533 T20826 T20819 punct ",",normalized
R16534 T20827 T20819 advmod respectively,normalized
R16535 T20828 T20801 punct .,quantified
R16598 T20925 T20930 nmod Immunoblotting,cells
R16599 T20926 T20930 amod Differentiated,cells
R16600 T20927 T20930 compound CD4,cells
R16601 T20928 T20930 amod +,cells
R16602 T20929 T20930 compound T,cells
R16603 T20930 T20932 nsubjpass cells,rested
R16604 T20931 T20932 auxpass were,rested
R16605 T20932 T20932 ROOT rested,rested
R16606 T20933 T20932 prep for,rested
R16607 T20934 T20935 nummod 5,hr
R16608 T20935 T20933 pobj hr,for
R16609 T20936 T20932 prep in,rested
R16610 T20937 T20938 nummod 1,%
R16611 T20938 T20940 nmod %,medium
R16612 T20939 T20940 amod FCS-containing,medium
R16613 T20940 T20936 pobj medium,in
R16614 T20941 T20932 cc and,rested
R16615 T20942 T20932 conj restimulated,rested
R16616 T20943 T20944 mark as,described
R16617 T20944 T20942 advcl described,restimulated
R16618 T20945 T20944 prep for,described
R16619 T20946 T20947 amod specific,experiments
R16620 T20947 T20945 pobj experiments,for
R16621 T20948 T20932 punct .,rested
R16622 T20949 T20950 compound Cell,lysates
R16623 T20950 T20951 nsubj lysates,were
R16624 T20951 T20951 ROOT were,were
R16625 T20952 T20951 acomp prepared,were
R16626 T20953 T20952 punct ",",prepared
R16627 T20954 T20955 amod equal,amounts
R5742 T7472 T7471 cc and,IL-10

UBERON-AE

Id Subject Object Predicate Lexical cue
T1013 1857-1860 http://purl.obolibrary.org/obo/UBERON_2000711 denotes Del
T6990 12414-12434 http://purl.obolibrary.org/obo/UBERON_0001542 denotes inguinal lymph nodes
T6991 12423-12428 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
T6992 12423-12434 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
T13948 21895-21909 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T13949 23208-23214 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T13950 30110-30116 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T13951 23511-23516 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T13952 28118-28127 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
T20230 33986-33991 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T20231 34018-34024 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T20232 34220-34240 http://purl.obolibrary.org/obo/UBERON_0001542 denotes inguinal lymph nodes
T20233 34229-34234 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
T20234 34229-34240 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes

GO-BP

Id Subject Object Predicate Lexical cue
T571 0-25 http://purl.obolibrary.org/obo/GO_0032613 denotes Interleukin-10 Production
T572 633-649 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T573 1221-1237 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T574 0-25 http://purl.obolibrary.org/obo/GO_0032653 denotes Interleukin-10 Production
T575 633-649 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T576 1221-1237 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T577 0-25 http://purl.obolibrary.org/obo/GO_0032693 denotes Interleukin-10 Production
T578 0-25 http://purl.obolibrary.org/obo/GO_0032733 denotes Interleukin-10 Production
T579 77-90 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T580 560-573 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T581 102-105 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T582 493-497 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T583 502-506 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T584 924-928 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T585 288-295 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T586 709-718 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T587 312-323 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T588 396-407 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T589 741-752 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T590 468-471 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T591 602-605 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T592 705-708 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T593 519-534 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T594 560-591 http://purl.obolibrary.org/obo/GO_0051091 denotes transcription factor activation
T595 560-591 http://purl.obolibrary.org/obo/GO_0032793 denotes transcription factor activation
T596 560-591 http://purl.obolibrary.org/obo/GO_1901485 denotes transcription factor activation
T597 1192-1208 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T2134 1438-1460 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T2135 5157-5178 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T2136 2387-2390 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T2137 4394-4397 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T2138 5449-5452 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T2139 2720-2736 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T2140 5188-5204 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T2141 5607-5626 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10
T2142 2720-2736 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T2143 5188-5204 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T2144 5607-5626 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T2145 2932-2942 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T2146 2932-2965 http://purl.obolibrary.org/obo/GO_0045088 denotes regulation of the immune response
T2147 2932-2965 http://purl.obolibrary.org/obo/GO_0060330 denotes regulation of the immune response
T2148 2932-2965 http://purl.obolibrary.org/obo/GO_0002828 denotes regulation of the immune response
T2149 2932-2965 http://purl.obolibrary.org/obo/GO_0050776 denotes regulation of the immune response
T2150 2932-2965 http://purl.obolibrary.org/obo/GO_0050777 denotes regulation of the immune response
T2151 2932-2965 http://purl.obolibrary.org/obo/GO_0050778 denotes regulation of the immune response
T2152 2932-2965 http://purl.obolibrary.org/obo/GO_0002819 denotes regulation of the immune response
T2167 4825-4836 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2168 3526-3539 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T2169 3596-3609 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T2170 3721-3734 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T2171 3947-3960 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T2172 4121-4134 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T2173 4444-4447 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T2174 4483-4487 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T2175 4615-4619 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T2176 5499-5503 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T2177 4624-4628 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T2178 5508-5512 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T2179 5581-5585 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T2180 4457-4481 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T2181 4457-4481 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T2182 4457-4481 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T2183 4457-4481 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T2184 4489-4504 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2185 5513-5528 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2186 4615-4639 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T2187 4651-4669 http://purl.obolibrary.org/obo/GO_0071353 denotes responses and IL-4
T2188 4651-4669 http://purl.obolibrary.org/obo/GO_0070670 denotes responses and IL-4
T2189 4665-4679 http://purl.obolibrary.org/obo/GO_0072602 denotes IL-4 secretion
T2190 4670-4679 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T4162 5943-5954 http://purl.obolibrary.org/obo/GO_0032502 denotes Development
T4163 7157-7168 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4164 7594-7605 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4165 7972-7983 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4166 8697-8708 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4167 6076-6079 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T4168 6927-6943 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T4169 7322-7338 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T4170 7950-7966 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T4171 8634-8650 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T4172 6927-6943 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T4173 7322-7338 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T4174 7950-7966 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T4175 8634-8650 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T4176 7686-7706 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T4177 8336-8342 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T6307 8907-8923 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 Production
T6308 10401-10417 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T6309 11812-11828 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T6310 11984-12000 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T6311 8907-8923 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 Production
T6312 10401-10417 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T6313 11812-11828 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T6314 11984-12000 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T6315 9055-9066 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T6316 11417-11428 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T6317 11654-11665 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T6318 11728-11739 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T6319 9143-9152 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6320 9910-9919 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6321 10528-10537 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6322 10753-10762 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6323 11879-11888 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T6324 9143-9161 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T6325 11879-11897 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T6326 9143-9171 http://purl.obolibrary.org/obo/GO_0009736 denotes signaling pathways activated
T6327 9143-9171 http://purl.obolibrary.org/obo/GO_0033211 denotes signaling pathways activated
T6328 9143-9171 http://purl.obolibrary.org/obo/GO_1901186 denotes signaling pathways activated
T6329 9143-9171 http://purl.obolibrary.org/obo/GO_1902204 denotes signaling pathways activated
T6330 9143-9171 http://purl.obolibrary.org/obo/GO_0009873 denotes signaling pathways activated
T6331 9143-9171 http://purl.obolibrary.org/obo/GO_0038084 denotes signaling pathways activated
T6332 9143-9171 http://purl.obolibrary.org/obo/GO_1900236 denotes signaling pathways activated
T6333 9143-9171 http://purl.obolibrary.org/obo/GO_1902046 denotes signaling pathways activated
T6334 9143-9171 http://purl.obolibrary.org/obo/GO_1902843 denotes signaling pathways activated
T6335 9143-9171 http://purl.obolibrary.org/obo/GO_1903265 denotes signaling pathways activated
T6336 9932-9945 http://purl.obolibrary.org/obo/GO_0004913 denotes IL-4 receptor
T6337 10549-10564 http://purl.obolibrary.org/obo/GO_0032633 denotes IL-4 production
T6338 10549-10564 http://purl.obolibrary.org/obo/GO_0032673 denotes IL-4 production
T6339 11074-11083 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T6340 11074-11092 http://purl.obolibrary.org/obo/GO_0072608 denotes secretion of IL-10
T6341 11074-11092 http://purl.obolibrary.org/obo/GO_2001179 denotes secretion of IL-10
T6342 11990-12013 http://purl.obolibrary.org/obo/GO_0035744 denotes production by Th1 cells
T7551 12175-12191 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T7552 12590-12606 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T7553 13260-13276 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T7554 12175-12191 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T7555 12590-12606 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T7556 13260-13276 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T7557 12772-12781 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7558 13095-13104 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7559 12797-12808 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T8771 13408-13424 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 Production
T8772 13848-13864 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T8773 15543-15559 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T8774 13408-13424 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 Production
T8775 13848-13864 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T8776 15543-15559 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T8777 13447-13450 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T8778 13522-13525 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T8779 14139-14142 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T8780 13451-13457 http://purl.obolibrary.org/obo/GO_0023052 denotes Signal
T8781 13555-13561 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T8782 13586-13595 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8783 15117-15124 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T10380 15575-15591 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 Production
T10381 17129-17148 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10
T10382 17591-17607 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T10383 17842-17858 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T10384 17915-17931 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T10385 15575-15591 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 Production
T10386 17129-17148 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T10387 17591-17607 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T10388 17842-17858 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T10389 17915-17931 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T10390 15614-15618 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10391 15895-15899 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10392 16192-16196 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10393 16364-16368 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10394 16532-16536 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10395 17303-17307 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10396 15623-15627 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10397 15904-15908 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10398 16201-16205 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10399 16373-16377 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10400 16541-16545 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10401 17312-17316 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10402 16672-16675 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T10403 17746-17749 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10404 17750-17754 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10405 15847-15850 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10406 16942-16945 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T10407 15895-15919 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10408 16192-16216 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10409 16364-16388 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10410 16532-16556 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T10411 16715-16724 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10412 17714-17723 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10413 18011-18020 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10414 17264-17268 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10415 17412-17416 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10416 17274-17278 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10417 17421-17425 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10418 17493-17497 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10419 17714-17732 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T10420 17997-18020 http://purl.obolibrary.org/obo/GO_0070371 denotes ERK1 and ERK2 signaling
T11411 18080-18096 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 Production
T11412 18177-18193 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T11413 18606-18622 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T11414 18984-19000 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T11415 18080-18096 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 Production
T11416 18177-18193 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T11417 18606-18622 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T11418 18984-19000 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T11419 18133-18137 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T11420 18238-18242 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T11421 18492-18496 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T11422 18142-18146 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T11423 18247-18251 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T11424 18501-18505 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T11425 18776-18779 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11426 18780-18784 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11427 18238-18262 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T11428 18492-18516 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T11429 18267-18293 http://purl.obolibrary.org/obo/GO_0030154 denotes differentiated these cells
T11430 18791-18794 http://purl.obolibrary.org/obo/GO_0050321 denotes GSK
T11431 18897-18928 http://purl.obolibrary.org/obo/GO_0070371 denotes ERK1 and ERK2 signaling pathway
T11432 18897-18928 http://purl.obolibrary.org/obo/GO_0070372 denotes ERK1 and ERK2 signaling pathway
T11433 18911-18920 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11434 18911-18928 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T13078 19064-19080 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 Production
T13079 19178-19194 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T13080 19064-19080 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 Production
T13081 19178-19194 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T13082 19349-19362 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13083 19421-19434 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13084 19531-19544 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13085 19745-19758 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13086 20119-20132 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13087 21546-21559 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T13088 19384-19386 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T13089 20261-20281 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T13090 20501-20521 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T13091 21726-21730 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T13092 21735-21739 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T17510 21964-21974 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T17511 27478-27488 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T17512 28013-28023 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T17513 30350-30360 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T17514 21964-21997 http://purl.obolibrary.org/obo/GO_0045088 denotes regulation of the immune response
T17515 23278-23300 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T17516 21964-21997 http://purl.obolibrary.org/obo/GO_0060330 denotes regulation of the immune response
T17517 21964-21997 http://purl.obolibrary.org/obo/GO_0002828 denotes regulation of the immune response
T17518 21964-21997 http://purl.obolibrary.org/obo/GO_0050776 denotes regulation of the immune response
T17519 21964-21997 http://purl.obolibrary.org/obo/GO_0050777 denotes regulation of the immune response
T17520 21964-21997 http://purl.obolibrary.org/obo/GO_0050778 denotes regulation of the immune response
T17521 21964-21997 http://purl.obolibrary.org/obo/GO_0002819 denotes regulation of the immune response
T17522 21964-21997 http://purl.obolibrary.org/obo/GO_0002920 denotes regulation of the immune response
T17523 21982-21997 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17524 22103-22118 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17525 23285-23300 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17526 23570-23585 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17527 23802-23817 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17528 24120-24135 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T17529 22295-22302 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T17530 27059-27066 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T17531 30060-30067 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T17532 22447-22451 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17533 22549-22553 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17534 26346-26350 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17535 27445-27449 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17536 27827-27831 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17537 22456-22460 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17538 22558-22562 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17539 26355-26359 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17540 27454-27458 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17541 27836-27840 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17542 29310-29313 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T17543 22461-22476 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T17544 22549-22573 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T17545 26346-26370 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T17546 27445-27469 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T17547 27827-27851 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T17548 29687-29711 http://purl.obolibrary.org/obo/GO_0070374 denotes ERK1 and ERK2 activation
T17549 22612-22631 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10
T17550 24658-24677 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10
T17551 30142-30161 http://purl.obolibrary.org/obo/GO_0032653 denotes production of IL-10
T17552 30364-30380 http://purl.obolibrary.org/obo/GO_0032653 denotes IL-10 production
T17553 22612-22631 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T17554 24658-24677 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T17555 30142-30161 http://purl.obolibrary.org/obo/GO_0032613 denotes production of IL-10
T17556 30364-30380 http://purl.obolibrary.org/obo/GO_0032613 denotes IL-10 production
T17557 22806-22818 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17558 24004-24016 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17559 30090-30102 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17560 23278-23300 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T17561 23278-23300 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T17562 23278-23300 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T17563 23278-23300 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T17564 23278-23300 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T17565 24834-24837 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T17566 26526-26529 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T17567 25509-25520 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T17568 26464-26480 http://purl.obolibrary.org/obo/GO_0032655 denotes IL-12 production
T17569 26566-26582 http://purl.obolibrary.org/obo/GO_0032655 denotes IL-12 production
T17570 26464-26480 http://purl.obolibrary.org/obo/GO_0032615 denotes IL-12 production
T17571 26566-26582 http://purl.obolibrary.org/obo/GO_0032615 denotes IL-12 production
T17572 27348-27363 http://purl.obolibrary.org/obo/GO_0032633 denotes IL-4 production
T17573 27348-27363 http://purl.obolibrary.org/obo/GO_0032673 denotes IL-4 production
T17574 27611-27626 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T17575 27997-28012 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T17576 29622-29637 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T17577 28128-28147 http://purl.obolibrary.org/obo/GO_0016573 denotes histone acetylation
T18970 30663-30666 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T18971 31599-31611 http://purl.obolibrary.org/obo/GO_0009058 denotes Biosynthesis
T18972 31687-31690 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19807 33203-33206 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20833 34716-34718 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T20834 34967-34980 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T20835 35206-35210 http://purl.obolibrary.org/obo/GO_0004422 denotes HPRT
T20986 35496-35499 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T2153 2932-2965 http://purl.obolibrary.org/obo/GO_0002920 denotes regulation of the immune response
T2154 2950-2965 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T2155 3361-3370 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2156 3659-3668 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2157 4398-4407 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2158 4925-4934 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2159 5431-5440 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2160 3361-3379 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T2161 4925-4943 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T2162 3465-3481 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T2163 3857-3873 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T2164 3470-3481 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2165 3862-3873 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2166 4031-4042 http://purl.obolibrary.org/obo/GO_0032502 denotes development

GO-MF

Id Subject Object Predicate Lexical cue
T598 102-105 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T599 493-497 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T600 502-506 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T601 924-928 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T602 203-209 http://purl.obolibrary.org/obo/GO_0005141 denotes 10 (IL
T603 327-332 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T604 411-416 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T605 633-638 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T606 772-777 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T607 972-977 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T608 1002-1007 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T609 1221-1226 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T610 218-230 http://purl.obolibrary.org/obo/GO_0005133 denotes interferon-γ
T611 540-545 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T612 678-683 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T2191 1265-1271 http://purl.obolibrary.org/obo/GO_0005141 denotes 10 (IL
T2192 1410-1415 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2193 1687-1692 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2194 2338-2343 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2195 2591-2596 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2196 2720-2725 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2197 3058-3063 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2198 5004-5009 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2199 5188-5193 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2200 5352-5357 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2201 5621-5626 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2202 5708-5713 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T2203 2313-2325 http://purl.obolibrary.org/obo/GO_0005133 denotes interferon-γ
T2204 2423-2428 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T2205 3639-3644 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T2206 4549-4554 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T2207 5411-5416 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T2208 3692-3697 http://purl.obolibrary.org/obo/GO_0045515 denotes IL-18
T2209 3894-3898 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T2210 3926-3930 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T2211 4665-4669 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T2212 3900-3904 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T2213 3910-3915 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T2214 3973-3980 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T2215 3973-3988 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T2216 4066-4070 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T2217 4444-4447 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T2218 4483-4487 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T2219 4615-4619 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T2220 5499-5503 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T2221 4624-4628 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T2222 5508-5512 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T2223 5581-5585 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T2224 4457-4481 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T4178 5900-5905 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4179 6689-6694 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4180 6999-7004 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4181 7105-7110 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4182 7137-7142 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4183 7268-7273 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4184 7440-7445 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4185 7649-7654 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4186 7828-7833 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4187 8203-8208 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4188 8771-8776 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T4189 5978-5983 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4190 6048-6053 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4191 6360-6365 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4192 6525-6530 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4193 6767-6772 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4194 6871-6876 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4195 6927-6932 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4196 7234-7239 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4197 7322-7327 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4198 7478-7483 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4199 7530-7535 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4200 7629-7634 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4201 7735-7740 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4202 7950-7955 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4203 7992-7997 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4204 8227-8232 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4205 8431-8436 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4206 8634-8639 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4207 8712-8717 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T4208 6516-6520 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4209 6817-6821 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T4210 6659-6669 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4211 7786-7790 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T4212 8052-8056 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T4213 8850-8854 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T6343 8907-8912 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6344 9090-9095 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6345 9327-9332 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6346 9654-9659 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6347 9710-9715 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6348 9749-9754 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6349 9872-9877 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6350 10076-10081 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6351 10239-10244 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6352 10401-10406 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6353 10539-10544 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6354 10686-10691 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6355 10859-10864 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6356 11087-11092 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6357 11220-11225 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6358 11452-11457 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6359 11689-11694 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6360 11763-11768 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6361 11812-11817 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6362 11984-11989 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T6363 8987-8991 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6364 9640-9644 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6365 9788-9792 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6366 9932-9936 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6367 10392-10396 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6368 10444-10448 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6369 10549-10553 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6370 11329-11333 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6371 11405-11409 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6372 11490-11494 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6373 11617-11621 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T6374 9175-9180 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6375 9305-9310 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6376 9417-9422 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6377 10121-10126 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6378 11035-11040 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6379 11130-11135 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6380 11529-11534 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T6381 9932-9945 http://purl.obolibrary.org/obo/GO_0004913 denotes IL-4 receptor
T7560 12112-12117 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T7561 12175-12180 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T7562 12544-12549 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T7563 12590-12595 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T7564 12812-12817 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T7565 13005-13010 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T7566 13260-13265 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8784 13408-13413 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8785 13616-13621 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8786 13848-13853 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8787 13949-13954 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8788 14087-14092 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8789 14190-14195 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8790 14236-14241 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8791 14447-14452 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8792 14518-14523 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8793 14838-14843 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8794 14919-14924 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8795 15156-15161 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8796 15326-15331 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8797 15370-15375 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8798 15543-15548 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T8799 13471-13476 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8800 13566-13571 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8801 13757-13762 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8802 13813-13818 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8803 14051-14056 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8804 14180-14185 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8805 14354-14359 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8806 14627-14632 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8807 14772-14777 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8808 14883-14888 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8809 15027-15032 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8810 15111-15116 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8811 15237-15242 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8812 15408-15413 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T8813 15492-15497 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10421 15575-15580 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10422 15679-15684 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10423 16591-16596 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10424 17028-17033 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10425 17143-17148 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10426 17591-17596 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10427 17842-17847 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10428 17915-17920 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T10429 15614-15618 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10430 15895-15899 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10431 16192-16196 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10432 16364-16368 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10433 16532-16536 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10434 17303-17307 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T10435 15623-15627 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10436 15904-15908 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10437 16201-16205 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10438 16373-16377 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10439 16541-16545 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10440 17312-17316 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T10441 16672-16675 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T10442 17746-17749 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10443 17750-17754 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10444 15818-15823 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10445 16408-16413 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10446 16895-16900 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10447 16972-16977 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10448 17982-17987 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T10449 17264-17268 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10450 17412-17416 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T10451 17274-17278 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T11435 18080-18085 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T11436 18177-18182 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T11437 18563-18568 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T11438 18606-18611 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T11439 18842-18847 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T11440 18984-18989 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T11441 18133-18137 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T11442 18238-18242 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T11443 18492-18496 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T11444 18142-18146 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T11445 18247-18251 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T11446 18501-18505 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T11447 18776-18779 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T11448 18780-18784 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T11449 18791-18794 http://purl.obolibrary.org/obo/GO_0050321 denotes GSK
T13093 19064-19069 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T13094 19178-19183 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T13095 19994-19999 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T13096 21146-21151 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T13097 21443-21448 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T13098 19295-19300 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13099 19496-19501 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13100 19568-19573 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13101 19647-19652 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13102 19958-19963 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13103 20083-20088 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13104 20401-20406 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13105 20661-20666 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13106 20911-20916 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13107 21017-21022 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T13108 19384-19386 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T13109 21726-21730 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T13110 21735-21739 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T17578 21842-21847 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17579 22039-22044 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17580 22184-22189 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17581 22355-22360 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17582 22524-22529 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17583 22626-22631 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17584 22723-22728 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17585 23107-23112 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17586 23397-23402 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17587 23433-23438 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17588 23702-23707 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17589 23753-23758 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17590 23939-23944 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17591 24086-24091 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17592 24489-24494 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17593 24672-24677 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17594 24893-24898 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17595 25031-25036 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17596 25395-25400 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17597 25544-25549 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17598 25580-25585 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17599 25773-25778 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17600 25968-25973 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17601 26024-26029 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17602 26290-26295 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17603 26701-26706 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17604 26777-26782 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17605 26810-26815 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17606 27106-27111 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17607 27221-27226 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17608 27492-27497 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17609 27666-27671 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17610 27872-27877 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17611 28027-28032 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17612 28155-28160 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17613 28275-28280 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17614 28519-28524 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17615 28590-28595 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17616 28650-28655 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17617 28728-28733 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17618 28780-28785 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17619 29002-29007 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17620 29236-29241 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17621 29287-29292 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17622 29454-29459 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17623 29680-29685 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17624 29728-29733 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17625 29808-29813 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17626 29865-29870 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17627 30156-30161 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17628 30364-30369 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T17629 22447-22451 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17630 22549-22553 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17631 26346-26350 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17632 27445-27449 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17633 27827-27831 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T17634 22456-22460 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17635 22558-22562 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17636 26355-26359 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17637 27454-27458 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17638 27836-27840 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T17639 29310-29313 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK
T17640 22481-22486 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17641 24374-24379 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17642 25369-25374 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17643 25556-25561 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17644 25643-25648 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17645 26117-26122 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17646 26171-26176 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17647 26250-26255 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17648 26464-26469 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17649 26566-26571 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17650 26741-26746 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17651 28486-28491 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17652 28625-28630 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17653 28894-28899 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17654 29168-29173 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17655 29955-29960 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T17656 24507-24511 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T17657 24635-24639 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T17658 27348-27352 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T17659 28634-28638 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T18973 30698-30702 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T18974 31216-31226 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T18975 31687-31690 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10452 17421-17425 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T10453 17493-17497 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK2
T19808 32555-32560 http://purl.obolibrary.org/obo/GO_0005143 denotes IL-12
T19809 33203-33206 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20191 33842-33846 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T20192 33848-33853 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T20575 34620-34625 http://purl.obolibrary.org/obo/GO_0005141 denotes IL-10
T20836 34716-34718 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T20837 35193-35202 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T20838 35206-35210 http://purl.obolibrary.org/obo/GO_0004422 denotes HPRT
T20987 35496-35499 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK

GO-CC

Id Subject Object Predicate Lexical cue
T613 175-180 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T614 360-365 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T615 431-436 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T616 657-662 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T617 792-797 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T618 827-832 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T619 1132-1137 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T620 468-471 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T621 602-605 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T622 705-708 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T2227 2260-2264 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2228 2372-2376 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2229 2557-2561 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2230 3317-3321 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
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T2232 3857-3861 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2233 4214-4218 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
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T2240 5805-5809 http://purl.obolibrary.org/obo/GO_0018995 denotes host
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T2242 4394-4397 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T2243 5449-5452 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
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T10463 15847-15850 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10464 16942-16945 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10465 16765-16768 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T10466 16912-16915 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T11450 18210-18215 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
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T17705 24834-24837 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
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T19810 31853-31857 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
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T19823 32562-32565 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
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T20988 35276-35281 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20989 35387-35391 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell

sentences

Id Subject Object Predicate Lexical cue
T145 0-148 Sentence denotes Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose
T146 160-167 Sentence denotes Summary
T147 168-274 Sentence denotes CD4+ T cells producing interleukin-10 (IL-10) and interferon-γ (IFN-γ) are reported in chronic infections.
T148 275-380 Sentence denotes However, the signals that direct the development of IL-10-producing T helper 1 (Th1) cells are undefined.
T149 381-592 Sentence denotes We showed that development of IL-10-producing Th1 cells required high T cell receptor (TCR) ligation, sustained ERK1 and ERK2 MAP kinases phosphorylation, and IL-12-induced STAT4 transcription factor activation.
T150 593-798 Sentence denotes Repeated TCR triggering led to enhanced IL-10 production by Th1 cells, and continued IL-12 action and high-dose TCR signaling were required for the development and maintenance of IL-10-producing Th1 cells.
T151 799-1001 Sentence denotes Although Th1, Th2, and Th17 cells require the activation of distinct STATs for their differentiation, activation of ERK1 and ERK2 was a common requirement for production of IL-10 by all Th cell subsets.
T152 1002-1057 Sentence denotes IL-10 expression also correlated with c-maf expression.
T153 1058-1238 Sentence denotes Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production.
T2963 5900-5983 Sentence denotes IL-12 and High Doses of Antigen Induce the Development of Th1 Cells Producing IL-10
T2964 5984-6200 Sentence denotes To study the differentiation of Th1 cells coproducing IFN-γ and IL-10, we cultured purified TCR-transgenic DO11.10 naive CD4+ T cells with purified DCs as APCs and increasing doses of ovalbumin peptide 323-339 (OVA).
T2965 6201-6396 Sentence denotes Culture with high doses of antigen for 7 days gave rise to Th1 cells expressing IFN-γ upon restimulation (Constant et al., 1995; Hosken et al., 1995), but not IL-10 (Figure S1A available online).
T2966 6397-6563 Sentence denotes Culture with low antigen doses under the same conditions led to the differentiation of Th2 cells, which expressed both IL-4 and IL-10 upon restimulation (Figure S1A).
T2967 6564-6835 Sentence denotes Culture of naive CD4+ T cells in an APC-free system by stimulation with anti-CD3 and anti-CD28 antibodies in the presence of IL-12 resulted in IFN-γ-producing Th1 cells, a proportion of which coproduced IL-10, as did Th2 cells resulting from culture in IL-4 (Figure S1B).
T2968 6836-7111 Sentence denotes To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12.
T2969 7112-7364 Sentence denotes At low doses of antigen, IL-12 abrogated the development of Th2 cells and induced IFN-γ expression but only low levels of IL-10 expression, suggesting that IL-12 per se was not sufficient to induce significant IL-10 production in Th1 cells (Figure 1A).
T2970 7365-7583 Sentence denotes Strikingly, as the antigen dose was increased, Th1 populations driven with IL-12 now contained higher numbers of IL-10-producing cells (Figure 1A) and produced more IL-10 protein upon restimulation (Figures 1A and 1B).
T2971 7584-7681 Sentence denotes Thus, the development of Th1 cells producing IL-10 required both IL-12 and high doses of antigen.
T2972 7682-7803 Sentence denotes Th1 cells differentiated to produce large amounts of IL-10 and IFN-γ and lost their capacity to produce IL-2 (Figure 1B).
T2973 7804-8057 Sentence denotes Because the presence of IL-12 reduced the proliferation of CD4+ T cells at both high and low antigen doses (Table S1), and only the former showed IL-10 production, the development of high IL-10-producing cells is most likely not related to limited IL-2.
T2974 8058-8377 Sentence denotes Naive CD4+ T cells from DO11.10/recombination-activating gene 1 (Rag1)-deficient animals, cultured with high doses of antigen in the presence of IL-12, also resulted in IL-10 expression by Th1 cells, showing that this expression was not dependent on the presence of effector or memory T cells or Treg cells (Figure S2).
T2975 8378-8583 Sentence denotes Although it has been suggested that TGF-β can induce IL-10 in CD4+ T cells (Kitani et al., 2003; Schiott et al., 2000), we found that in developing Th1 and Th2 cells this was not the case (data not shown).
T2976 8584-8686 Sentence denotes In fact, neutralization of TGF-β led to increased IL-10 production by both T cell subsets (Figure S3).
T2977 8687-8905 Sentence denotes Thus, the development of IL-10-producing Th1 cells only depended on the presence of IL-12 together with high antigen dose and not on other soluble factors such as IL-2 or TGF-β or on the presence of other T cell types.
T5019 8907-9001 Sentence denotes IL-10 Production by Th1 Cells Is Dependent on STAT4 but Not on STAT6, IFN-γ, or IL-4 Signaling
T5020 9002-9203 Sentence denotes To further elucidate the mechanisms required for the development of Th1 cells producing IL-10, we investigated the role of STAT4, one of the signaling pathways activated by IL-12 (Murphy et al., 2000).
T5021 9204-9319 Sentence denotes Naive CD4+ D011.10 T cells deficient in STAT4 (Ouyang et al., 1998) were cultured in the presence of IL-12 and OVA.
T5022 9320-9454 Sentence denotes Again, IL-10-producing Th1 cells were differentiated at the high antigen dose in the presence of IL-12 in DO11.10 T cells (Figure 2A).
T5023 9455-9740 Sentence denotes In contrast, in the absence of STAT4, the percentage of cells expressing IFN-γ was dramatically diminished as expected and resulted in an increase in the percentage of cells expressing IL-4, but not IL-10 (Figure 2A), suggesting that STAT4 contributes to IL-10 expression by Th1 cells.
T5024 9741-10016 Sentence denotes Because IL-10 expression is associated with an IL-4-induced Th2 cell phenotype, we investigated whether the differentiation of the IL-10-producing Th1 cells depended on signaling through the IL-4 receptor via STAT6 activation (Glimcher and Murphy, 2000; Murphy et al., 2000).
T5025 10017-10147 Sentence denotes The absence of STAT6 did not impair the differentiation of IL-10-producing Th1 cells in the presence of IL-12 and OVA (Figure 2A).
T5026 10148-10349 Sentence denotes In fact, a higher percentage of STAT6-deficient cells compared with WT cells produced both IL-10 and IFN-γ (Figure 2A), which may be the result of the loss of Th2 cell control over a Th1 cell response.
T5027 10350-10494 Sentence denotes As expected, lack of STAT6 abrogated both IL-4 and IL-10 production by T cells developed with IL-4 or with low antigen dose (Figures 2B and 2C).
T5028 10495-10624 Sentence denotes However, in the absence of STAT4 signaling, IL-10 and IL-4 production by Th2 cells was if anything increased (Figures 2B and 2C).
T5029 10625-10783 Sentence denotes Thus, in contrast to what was observed under Th1 conditions, IL-10 expression by Th2 cells depended on STAT6, but not on STAT4, signaling (Figures 2B and 2C).
T5030 10784-11069 Sentence denotes To investigate whether the inability of STAT4-deficient T cells to produce IL-10 might be due to the absence of IFN-γ, as suggested before (Shaw et al., 2006), we differentiated DO11.10 or DO11.10 IFN-γ-deficient naive CD4+ T cells in the presence of IL-12 and increasing doses of OVA.
T5031 11070-11263 Sentence denotes The secretion of IL-10 as induced by high antigen dose, and IL-12 was not affected by an absence of IFN-γ (Figure 2D), showing that the expression of IL-10 by Th1 cells is independent of IFN-γ.
T5032 11264-11363 Sentence denotes In the absence of IFN-γ, we observed an increase in the secreted IL-4 as expected (data not shown).
T5033 11364-11567 Sentence denotes We also tested for any potential role of IL-4 in the development of Th1 cells producing IL-10 by culturing DO11.10 or DO11.10 IL-4-deficient naive CD4+ T cells with IL-12 and increasing doses of antigen.
T5034 11568-11781 Sentence denotes As observed in the absence of STAT6 (Figure 2A), IL-4 deficiency had no effect on the development of Th1 cells producing IL-10 (Figure 2E), but compromised the development of Th2 cells producing IL-10 (Figure 2F).
T5035 11782-12038 Sentence denotes Thus, our data suggested that IL-10 production by Th1 or Th2 cells was dependent on the specific signaling pathways required for their differentiation, given that STAT4 is required for the induction of IL-10 production by Th1 cells and STAT6 for Th2 cells.
T7035 12040-12137 Sentence denotes High Antigen Doses and STAT4 Are Required for the In Vivo Generation of IL-10-Producing Th1 Cells
T7036 12138-12381 Sentence denotes To address the mechanisms regulating IL-10 production by Th1 cells in vivo, we transferred DO11.10 cells into BALB/c recipient mice and immunized the recipients with very high doses of OVA-protein with or without added lipopolysacharide (LPS).
T7037 12382-12509 Sentence denotes T cells were recovered from the inguinal lymph nodes 3 days after priming and restimulated in vitro with OVA peptide for 48 hr.
T7038 12510-12735 Sentence denotes This in vivo immunization induced IL-10 and IFN-γ production, and the amount of IL-10 production was enhanced by addition of LPS in the immunization (Figure 3A) and with higher doses of OVA (3 μM versus 1 μM, data not shown).
T7039 12736-12977 Sentence denotes To test the role of STAT4 and STAT6 signaling in the in vivo development of IL-10-producing Th1 cells, we transferred STAT4- or STAT6-deficient or WT DO11.10 cells into recipient BALB/c mice and immunized with OVA-protein plus LPS as before.
T7040 12978-13218 Sentence denotes In vivo expression of both IL-10 and IFN-γ was markedly reduced but not completely abrogated in the absence of STAT4 signaling (Figures 3B and 3C), suggesting the existence of compensatory mechanisms that were absent in the in vitro system.
T7041 13219-13406 Sentence denotes Signaling through STAT6 had no effect on IL-10 production by Th1 cells as shown by intracellular cytokine staining (ICS) and by immunoassay in STAT6-deficient T cells (Figures 3B and 3C).
T7927 13408-13476 Sentence denotes IL-10 Production Is Maintained by High TCR Signal Strength and IL-12
T7928 13477-13635 Sentence denotes We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells.
T7929 13636-13790 Sentence denotes For this, CD4+ T cells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A–4D).
T7930 13791-13975 Sentence denotes High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells.
T7931 13976-14226 Sentence denotes Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D).
T7932 14227-14347 Sentence denotes However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure 4E).
T7933 14348-14466 Sentence denotes Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells.
T7934 14467-14790 Sentence denotes To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ T cells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure 4F).
T7935 14791-15162 Sentence denotes Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure 4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10.
T7936 15163-15463 Sentence denotes Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-γ but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (Figure S4).
T7937 15464-15573 Sentence denotes Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.
T9380 15575-15638 Sentence denotes IL-10 Production by Th1 Cells Requires ERK1 and ERK2 Activation
T9381 15639-15824 Sentence denotes Our data showed that the maintenance of IL-10 induction in Th1 cells required stimulation with high antigen dose, which to some extent could be compensated for by the addition of IL-12.
T9382 15825-16150 Sentence denotes Signaling through the TCR with high doses of antigen induced stronger ERK1 and ERK2 activation than that induced by low antigen dose, not only in naive CD4+ T cells (data not shown) as previously demonstrated (Jorritsma et al., 2003) but also in CD4+ T cells restimulated with the same high and low antigen doses (Figure 5A).
T9383 16151-16502 Sentence denotes Although the apparent peak and amount of ERK1 and ERK2 activation varied slightly between experiments, a consistent finding was that high antigen dose differentiated Th1 cells always showed enhanced and prolonged ERK1 and ERK2 activation in the presence of IL-12, regardless of whether they were restimulated with high or low antigen dose (Figure 5B).
T9384 16503-16687 Sentence denotes We then investigated whether ERK1 and ERK2 activation was required for the induction of IL-10 in Th1 cells by using U0126 (Figure 5C), a compound that blocks downstream ERK activation.
T9385 16688-16901 Sentence denotes To ensure that only T cell signaling was being affected by U0126, we used an APC-free system in which the T cells were differentiated in the presence of increasing doses of anti-CD3 and a constant amount of IL-12.
T9386 16902-17080 Sentence denotes As in the APC-driven cultures, stronger TCR stimulation together with IL-12 led to higher percentages of cells producing both IL-10 and IFN-γ after 1 week of culture (Figure 5C).
T9387 17081-17186 Sentence denotes Addition of U0126 to the cultures abrogated the production of IL-10 at all doses of anti-CD3 (Figure 5C).
T9388 17187-17550 Sentence denotes Because U0126 inhibits the MEK5-catalyzed activation of ERK5, as well as the MEK1- and MEK2-catalyzed activation of ERK1 and ERK2 (Bain et al., 2007; Mody et al., 2001), we also used the more specific, structurally unrelated MEK1 and MEK2 inhibitor PD184352 at concentrations in which it inhibits MEK1 and MEK2 but not MEK5 (Bain et al., 2007; Mody et al., 2001).
T9389 17551-17676 Sentence denotes PD184352 caused a similar inhibition of IL-10 production by Th1 cells in a dose-dependent fashion (Figure 5D and Figure S5A).
T9390 17677-17885 Sentence denotes Upon addition of inhibitors to other signaling pathways, including a p38 MAPK inhibitor, SB203580, or the GSK3β inhibitor, CT99021 (Bain et al., 2007), no effect on IL-10 production was observed (Figure S5B).
T9391 17886-18078 Sentence denotes Our data thus suggested that IL-10 production by Th1 cells in response to high antigen dose and IL-12 requires ERK1 and ERK2 signaling, but not the activation of the p38 or the GSK3β pathways.
T11022 18080-18157 Sentence denotes IL-10 Production by Th2 and Th17 Cells Also Requires ERK1 and ERK2 Activation
T11023 18158-18476 Sentence denotes To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352).
T11024 18477-18748 Sentence denotes We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B).
T11025 18749-18878 Sentence denotes In contrast, inhibitors of p38 MAPK or of GSK-3β activation did not affect the expression of IL-10 by these subsets (Figure S5B).
T11026 18879-19029 Sentence denotes Activation of the ERK1 and ERK2 signaling pathway is therefore a common requirement for the induction of IL-10 production by Th1, Th2, and Th17 cells.
T11943 19031-19108 Sentence denotes c-maf Expression Correlates with IL-10 Production in Th1, Th2, and Th17 Cells
T11944 19109-19391 Sentence denotes To investigate further the downstream factors involved in regulating IL-10 production, we differentiated DO11.10 CD4+ T cells with increasing doses of OVA, in the presence or absence of IL-12, and quantified the expression of cytokines and transcription factors by real-time RT-PCR.
T11945 19392-19514 Sentence denotes Low-dose antigen resulted in transcription of Il4 and this was abrogated by both high antigen doses and IL-12 (Figure 6A).
T11946 19515-19723 Sentence denotes A low amount of transcription of Ifnγ was induced by IL-12 when cells were differentiated with low antigen dose, but this effect of IL-12 was markedly upregulated with increasing doses of antigen (Figure 6A).
T11947 19724-19932 Sentence denotes A low amount of Il10 transcription was observed at low doses of antigen accompanying Il4 expression (Th2 cell response), and this was abrogated by increased doses of antigen as was Il4 expression (Figure 6A).
T11948 19933-20073 Sentence denotes At low doses of antigen, IL-12 had little effect to increase IL-10 mRNA expression (Figure 6A) in keeping with the protein data (Figure 1A).
T11949 20074-20253 Sentence denotes However, IL-12 induced a high amount of Il10 transcription as well as Ifnγ expression with increased antigen doses (Figure 6A), again in keeping with the protein data (Figure 1A).
T11950 20254-20419 Sentence denotes CD4+ T cells differentiated with increasing doses of antigen did not express high amounts of Tbx-21 (T-bet) mRNA, unless they were cocultured with IL-12 (Figure 6B).
T11951 20420-20679 Sentence denotes In contrast, high amounts of GATA-3 mRNA expression were only observed under Th2 cell differentiation conditions (low-dose antigen) (Figure 6B), and this expression was markedly downregulated by both increasing antigen dose and coculture in IL-12 (Figure 6B).
T11952 20680-20895 Sentence denotes Differentiation of T cells under low antigen dose led to expression of c-maf, in keeping with the Th2 cell profile (Ho et al., 1996), which was almost completely abrogated by increasing doses of antigen (Figure 6B).
T11953 20896-21006 Sentence denotes Interestingly, IL-12 sustained the high expression of c-Maf mRNA even at the highest antigen dose (Figure 6B).
T11954 21007-21098 Sentence denotes Moreover, IL-12 maintenance of c-maf expression required STAT4 activation (data not shown).
T11955 21099-21294 Sentence denotes In Th17 cells that expressed IL-17a as well as IL-10 mRNA (Figure 6C), T-bet and GATA-3 mRNA were undetectable (data not shown), whereas that of ROR-γt was high (Figure 6C) (Ivanov et al., 2007).
T11956 21295-21607 Sentence denotes Th17 cells also expressed high amounts of c-maf (Figure 6C), confirming a recent report (Bauquet et al., 2009). c-Maf is therefore expressed in all IL-10-expressing T cell populations tested (Figures 6B and 6C) and may not be just a Th2 cell-specific transcription factor as originally thought (Ho et al., 1996).
T11957 21608-21829 Sentence denotes We showed also that like Il10 expression, c-maf expression was inhibited in Th1 and Th17 cells in the presence of the MEK1 and MEK2 inhibitor (PD184352), whereas T-bet and RORγt expression was hardly affected (Figure 6D).
T14192 21842-22038 Sentence denotes IL-10 expression by cells of the innate and adaptive immune systems reflects the importance of this cytokine in the tight regulation of the immune response, to minimize pathology during infection.
T14193 22039-22154 Sentence denotes IL-10 expression by Th1 cells has been reported to regulate the immune response in leishmaniasis and toxoplasmosis.
T14194 22155-22256 Sentence denotes However, in many situations, IL-10 is not produced by Th1 cells in response to antigenic stimulation.
T14195 22257-22380 Sentence denotes Our goal was to address the molecular signals that determine whether Th1 cells develop to produce IL-10 (Trinchieri, 2007).
T14196 22381-22530 Sentence denotes Here, we showed that Th1 cells required high-antigen-dose-induced ERK1 and ERK2 phosphorylation and IL-12-induced STAT-4 activation to produce IL-10.
T14197 22531-22899 Sentence denotes Our findings that ERK1 and ERK2 activation was a common pathway required for the production of IL-10 by Th1, Th2, and Th17 cell subsets, which differentiate along distinct pathways, such that IL-10 provides a highly regulated feedback loop to avoid the extremes of excessive inflammation or chronic infections and also allow a protective response to diverse pathogens.
T14198 22900-23113 Sentence denotes In certain viral or parasitic infections (Anderson et al., 2007; Brooks et al., 2006; Ejrnaes et al., 2006), high amounts of stimulation may lead to the chronic nonhealing infection shown to be regulated by IL-10.
T14199 23114-23301 Sentence denotes During the course of infection, after initial triggering with antigen, T cells migrate to the tissue encountering high doses of antigen and factors produced by the innate immune response.
T14200 23302-23554 Sentence denotes Under these conditions, we speculate that Th1 cells will be induced to express high amounts of IL-10, in keeping with reports that IL-10-producing Th1 cells were found in CD4+ clones isolated from BAL but not blood of TB patients (Gerosa et al., 1999).
T14201 23555-23920 Sentence denotes Similarly, the immune response to a clinical isolate of L. major, which produces heavily infected nonhealing lesions, was found to be regulated by IL-10 derived from Foxp3− Th1 cells that coproduce IL-10 and IFN-γ (Anderson et al., 2007), and the immune response during T. gondii infection was found also to be regulated by Foxp3− Th1 cells (Jankovic et al., 2007).
T14202 23921-24298 Sentence denotes It is likely that IL-10 production by Th1 cells is evoked under conditions of high inflammation and antigenic stimulation, whereas regulatory CD4+ T cells producing IL-10 may operate to regulate the immune response under conditions in which the pathogen is clinically controlled, such as in infection with L. major (Friedlin strain) (Belkaid et al., 2002; Suffia et al., 2006).
T14203 24299-24603 Sentence denotes We now also reported that CD4+ T cells cultured with high antigen dose and IL-12 differentiate into canonical Th1 effector cells, which, in addition to expressing large amounts of IFN-γ and IL-10, lose their IL-2 expression as described before in certain chronic infection models (Sallusto et al., 2004).
T14204 24604-24790 Sentence denotes Our demonstration that loss of IL-2 is accompanied by production of IL-10 offers potential additional mechanisms whereby effector T cell responses may be dampened during chronic disease.
T14205 24791-24992 Sentence denotes Using an in vivo transfer model of DO11.10 TCR transgenic cells (Castro et al., 2000), we showed that IL-10-producing Th1 cells were differentiated in the presence of high doses of OVA protein and LPS.
T14206 24993-25187 Sentence denotes We showed here that this induction of IL-10 in Th1 cells in vivo was markedly, but not totally, reduced in STAT4-deficient T cells as observed during T. gondii infection (Jankovic et al., 2002).
T14207 25188-25414 Sentence denotes A high antigenic activation during T. gondii infection or high antigen doses delivered in the presence of LPS, as seen in our system, may compensate for an absolute requirement for IL-12 in the induction of IL-10 by Th1 cells.
T14230 29775-29992 Sentence denotes With regard to the expression of IL-10 by Th1 cells, our data provide a mechanism for how IL-10 expression is induced and then amplified and regulated by the levels of antigen and IL-12 encountered in the environment.
T14231 29993-30290 Sentence denotes This provides a mechanism whereby a Th1 cell responds to extrinsic signals, reflecting increased inflammation in the tissue, to tightly regulate the production of IL-10 so as to allow a protective response to eradicate a pathogen with minimal damage to the host and also prevent chronic infection.
T14232 30291-30540 Sentence denotes Moreover, our findings have important implications for the regulation of IL-10 production during an inflammatory Th1 response in infection and may be of relevance for the design of vaccines and for strategies in immunotherapy in infectious diseases.
T18692 30567-30614 Sentence denotes Mice, Cytokines, Antibodies, and Other Reagents
T18693 30615-31195 Sentence denotes BALB/c DO11.10 mice transgenic for OVA-specific TCR WT or crossed back with Rag1-, IL-4-, IFN-γ-, STAT4-, and STAT6-deficient mice were used as a source of antigen-specific T cells (Murphy et al., 1990; Ouyang et al., 1998; Shoemaker et al., 2006) and were bred and maintained under SPF conditions at the NIMR, London, Home Office, UK, Animals (Scientific Procedures) Act 1986 or at the Washington University School of Medicine. Female mice were used at 8–12 weeks old, and animal protocols were approved according to the Animals (Scientific Procedures) Act 1986, Home Office, UK.
T18694 31196-31432 Sentence denotes Reagents, including antibodies for T cell and DC preparation, purification and culture, media, cytokines, and cytokine mAbs have been described (Hosken et al., 1995; Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006).
T18695 31433-31803 Sentence denotes LPS (S. minnesota) was from Alexis, chicken ovalbumin protein (OVA protein) was from from Sigma-Aldrich, and ovalbumin peptide323-339 (OVA) (endotoxin-free) was from Biosynthesis. U0126 was from BioMol International. PD184352 (MEK inhibitors), SB203580 (p38 inhibitor), and CT99021 (GSK3β inhibitor) were kind gifts from P. Cohen and N. Shpiro, University of Dundee, UK.
T19130 31805-31902 Sentence denotes Isolation of CD4+ T Cells and of Splenic DC and Cell Culture for T Cell Phenotype Differentiation
T19131 31903-32077 Sentence denotes T cells were sorted for CD4+CD62Lhi, CD4+CD62LhiCD25−, or CD4+CD44loCD25− to >98% on a Moflo cytometer (Cytomation) as before (Shoemaker et al., 2006; Veldhoen et al., 2009).
T19132 32078-32201 Sentence denotes In most cases, experiments were reproduced with each type of purified CD4+ T cell population with similar results obtained.
T19133 32202-32328 Sentence denotes Splenic DCs were prepared as described (Hosken et al., 1995), and sort purified CD11c+ cells were added to the T cell culture.
T19134 32329-32561 Sentence denotes Purified DO11.10 CD4+ T cells (1 × 105 cells/ml) were cultured as before (Hosken et al., 1995), in a total volume of 1 ml cRPMI medium in a 48-well plate, with splenic DCs (2 × 104 cells/ml), and varying amounts of OVA and of IL-12.
T19135 32562-32831 Sentence denotes APC-independent differentiation of naive CD4+ T cells into Th1 and Th2 cells used stimulation with anti-CD3 and anti-CD28 and appropriate cytokine conditions, and control Th1 and Th2 cells were cultured as described before (Hosken et al., 1995; Shoemaker et al., 2006).
T19136 32832-32915 Sentence denotes Culture conditions for Th17 cells were as described before (Veldhoen et al., 2006).
T19137 32916-33140 Sentence denotes Importantly, Th1 and Th2 cells could be differentiated in cRPMI or IMDM (Hosken et al., 1995; Shoemaker et al., 2006; Veldhoen et al., 2006), but Th17 cells were only differentiated optimally in IMDM (Veldhoen et al., 2009).
T19138 33141-33302 Sentence denotes When indicated, U0126 or PD184352 (MEK inhibitors), SB203580 (p38 inhibitor), CT99021 (GSK3β inhibitor), or a similar amount of DMSO were present in the culture.
T19139 33303-33381 Sentence denotes More details of specific culture conditions are provided in Figures S6 and S7.
T19939 33383-33418 Sentence denotes Cytokine Detection by ICS and ELISA
T19940 33419-33629 Sentence denotes At day 5 or 7, cells were restimulated with immobilized anti-CD3 (2 μg/ml) and anti-CD28 (2 μg/ml) (4 hr with BrefeldinA [10 μg/ml] in the last 2 hr) or with PdBU and Ionomycin (5 hr with BrefeldinA [1 μg/ml]).
T19941 33630-33739 Sentence denotes After ICS FACS, data were collected on a FACSCalibur (Becton Dickinson) and analyzed with FlowJo (Tree Star).
T19942 33740-33910 Sentence denotes For ELISA, cells were similarly restimulated for 48 hr and supernatant was collected and analyzed for IL-4, IL-10, and IFN-γ as described before (Shoemaker et al., 2006).
T20243 33912-33927 Sentence denotes In Vivo Studies
T20244 33928-34115 Sentence denotes BALB/c mice were injected intravenously (i.v.) with a red blood cell-depleted single-cell spleen suspension (2.5 × 107 cells) (Castro et al., 2000) from DO11.10 WT or STAT-deficient mice.
T20245 34116-34215 Sentence denotes After 48 hr, they were injected subcutaneously with PBS or with OVA protein (5 mg) plus LPS (5 μg).
T20246 34216-34266 Sentence denotes The inguinal lymph nodes were removed 48 hr later.
T20247 34267-34404 Sentence denotes A single-cell suspension (1 × 106 cells) was restimulated for 24 or 48 hr with 1 μM or 3 μM of OVA and with BrefeldinA for the last 6 hr.
T20248 34405-34501 Sentence denotes Half of the supernatant was removed before the addition of BrefeldinA for use in an ELISA assay.
T20249 34502-34545 Sentence denotes The cells were fixed and stained as before.
T20250 34546-34691 Sentence denotes Those positive for KJ1-26-Bio and for CD4-PerCP were gated, and IFN-γ and IL-10 staining was examined for this population and analyzed as before.
T20630 34693-34722 Sentence denotes Real-Time Quantitative RT-PCR
T20631 34723-34866 Sentence denotes Cells were harvested and restimulated in the presence of immobilized anti-CD3 (2 μg/ml) plus anti-CD28 (2 μg/ml) for 3 hr or immediately lysed.
T20632 34867-35047 Sentence denotes RNA was extracted and reverse-transcribed and cDNA was analyzed for the expression of cytokines and transcription factors by real-time PCR assay as before (Shoemaker et al., 2006).
T20633 35048-35237 Sentence denotes Target gene mRNA expression was quantified either with SYBR Green (Applied Biosystems) or with Master Mix (Applied Biosystems) and normalized to ubiquitin or HPRT mRNA levels, respectively.
T20868 35239-35253 Sentence denotes Immunoblotting
T20869 35254-35386 Sentence denotes Differentiated CD4+ T cells were rested for 5 hr in 1% FCS-containing medium and restimulated as described for specific experiments.
T20870 35387-35566 Sentence denotes Cell lysates were prepared, equal amounts of protein were separated by SDS-PAGE, and phosphorylated or total ERK and actin were detected as described before (Beinke et al., 2004).
T1116 1253-1409 Sentence denotes Interleukin-10 (IL-10) is a cytokine with broad anti-inflammatory properties that inhibits macrophage and dendritic cell (DC) function (Moore et al., 2001).
T1117 1410-1686 Sentence denotes IL-10 limits the immune and inflammatory responses to pathogens and gut flora and prevents damage to the host (Moore et al., 2001; O'Garra and Vieira, 2004), but when dysregulated may result in chronic infection (Brooks et al., 2006; Ejrnaes et al., 2006; Moore et al., 2001).
T1118 1687-2228 Sentence denotes IL-10 is expressed by T helper 2 (Th2) cells, B cells, DCs, and macrophages (Moore et al., 2001), and also by Th1 cells (Anderson et al., 2007; Assenmacher et al., 1994; Del Prete et al., 1993; Gerosa et al., 1996; Jankovic et al., 2007; Pohl-Koppe et al., 1998) and (reviewed in O'Garra and Vieira, 2007; Trinchieri, 2007), certain regulatory (Treg) T cells (Moore et al., 2001; O'Garra and Vieira, 2004; Roncarolo et al., 2006), and Th17 cells (Awasthi et al., 2007; Fitzgerald et al., 2007; McGeachy et al., 2007; Stumhofer et al., 2007).
T1119 2229-2539 Sentence denotes In vitro human CD4+ and CD8+ T cell clones, or mouse CD4+ T cells that produce both interferon-γ (IFN-γ) and IL-10, can be differentiated by T cell receptor (TCR)-stimulation in the presence of IL-12 (Chang et al., 2007; Gerosa et al., 1996; Jeannin et al., 1996; Meyaard et al., 1996; Windhagen et al., 1996).
T1120 2540-2719 Sentence denotes Furthermore, Th1 cell clones coproducing IFN-γ and IL-10 have been isolated from bronchoalveolar lavage (BAL) of active pulmonary tuberculosis (TB) patients (Gerosa et al., 1999).
T1121 2720-3033 Sentence denotes IL-10 production by Th1 cells was also reported in animals infected with Toxoplasma gondii (Jankovic et al., 2002; Shaw et al., 2006) or with Leishmania major (Anderson et al., 2007) and shown to be required for regulation of the immune response in these infections (Anderson et al., 2007; Jankovic et al., 2007).
T1122 3034-3297 Sentence denotes The relative amounts of IL-10 and IFN-γ produced by Th1 cells may influence the balance between clearance and persistent infection with certain pathogens (Moore et al., 2001; Trinchieri, 2007), thus determining whether chronic infection or immunopathology ensues.
T1123 3298-3460 Sentence denotes Th1, Th2, and Th17 cell responses differentiate along distinct signaling pathways (Glimcher and Murphy, 2000; Ivanov et al., 2007; Stockinger and Veldhoen, 2007).
T1124 3461-3852 Sentence denotes Th1 cell development requires signal transducer and activator of transcription (STAT)1 activation, induced by type I IFN or IFN-γ, the transcription factor T-box 21 (T-bet), and IL-12-induced STAT4 signaling, which can couple with IL-18-induced IRAK and NF-κB transcription factors to drive the high amounts of IFN-γ required to eradicate intracellular pathogens (Glimcher and Murphy, 2000).
T1125 3853-4026 Sentence denotes Th2 cell development, with expression of IL-4, IL-5, and IL-13, requires IL-4, STAT6, and the transcription factor GATA binding protein (GATA)-3 (Glimcher and Murphy, 2000).
T1126 4027-4201 Sentence denotes The development of Th17 cells requires IL-6, TGF-β, and the STAT3-dependent expression of the transcription factor RORγt (Ivanov et al., 2007; Stockinger and Veldhoen, 2007).
T1127 4202-4347 Sentence denotes Th1 and Th2 cell responses can also be induced by varying the dose of antigen presented to the naive T cell by the antigen-presenting cell (APC).
T1128 4348-4770 Sentence denotes Whereas high doses of antigen, with sustained TCR signaling and extracellular-signal regulated (ERK) mitogen-activated protein kinase (MAPK) phosphorylation, result in Th1 cells producing IFN-γ via an IL-12-independent mechanism, low doses of antigen, with transient ERK1 and ERK2 activation, favor Th2 responses and IL-4 secretion (Constant et al., 1995; Hosken et al., 1995; Jorritsma et al., 2003; Yamane et al., 2005).
T1129 4771-5179 Sentence denotes Because Th1 and Th2 cells cross regulate each other's development and function and can suppress Th17 cell responses, and all differentiate along distinct signaling pathways (Glimcher and Murphy, 2000; Stockinger and Veldhoen, 2007), IL-10 produced by all these Th cells may thus act as a feedback regulator to control the pathology associated with an overexuberant, albeit efficacious, inflammatory response.
T1130 5180-5302 Sentence denotes Whether IL-10 production by these different Th cell subsets is induced by independent and/or common mechanisms is unknown.
T1131 5303-5529 Sentence denotes Here, we showed that in vitro differentiation of IL-10-producing Th1 cells from naive CD4+ T cells required IL-12-induced STAT4 signaling, strong TCR activation (high antigen dose), and sustained ERK1 and ERK2 phosphorylation.
T1132 5530-5662 Sentence denotes Furthermore, we showed that activation of ERK1 and ERK2 is a requirement for production of IL-10 by Th1, Th2, and Th17 cell subsets.
T1133 5663-5889 Sentence denotes This common but highly regulated pathway for IL-10 induction and maintenance ensures its function as a feedback loop to control damage to the host and also allows a protective response to ensue as opposed to chronic infection.
T14208 25415-25579 Sentence denotes In our in vitro system, repeated stimulation of Th1 cells with high antigen doses allowed the development of Th1 cells producing IL-10 in an IL-12-dependent manner.
T14209 25580-25733 Sentence denotes IL-10 production by Th1 cells induced by high antigen dose and IL-12 was independent of IFN-γ, in keeping with previous findings (Jankovic et al., 2002).
T14210 25734-25886 Sentence denotes However, a role for IFN-γ in mediating IL-10 reactivation by Th1 cells during secondary infection with T. gondii has been suggested (Shaw et al., 2006).
T14211 25887-26123 Sentence denotes We have found that CD4+ T cells exposed to a high dose of antigen do not express IL-10 upon restimulation, but can be induced to produce IL-10 upon re-exposure to a high dose of antigen in the recall phase in the absence of added IL-12.
T14212 26124-26203 Sentence denotes However, this is dependent on the induction of IL-12 by antigen-presenting DCs.
T14213 26204-26371 Sentence denotes The combination of both high antigen dose and IL-12 resulted in the highest levels of IL-10 production and correlated with the high levels of ERK1 and ERK2 activation.
T14214 26372-26589 Sentence denotes The increased expression of IFN-γ observed during the secondary phase will induce increased IL-12 production by DCs and suggests that repeated high-level TCR activation feeds back to upregulate IL-12 production by DC.
T14215 26590-26800 Sentence denotes It is thus likely that in T. gondii infection in vivo (Shaw et al., 2006), the requirement for IFN-γ to induce IL-10, was for feedback upregulation of IL-12 by DCs, which in turn induced IL-10 in the Th1 cells.
T14216 26801-27038 Sentence denotes Although IL-10 may be differentially regulated in Th1 and Th2 cells as has been reported (Chang et al., 2007; Wang et al., 2005), some studies suggest the existence of common pathways, but the molecular basis for these is as yet unclear.
T14217 27039-27293 Sentence denotes Costimulatory OX-40 signals have been shown to negatively regulate IL-10 production (Ito et al., 2005) both in Th1 and Th2 cells, whereas ICOS signaling has been suggested to induce IL-10 (Ito et al., 2007; Witsch et al., 2002) in both Th1 and Th2 cells.
T14218 27294-27407 Sentence denotes However, in some cases, ICOS signaling also regulates IL-4 production and Th2 responses (Greenwald et al., 2005).
T14219 27408-27635 Sentence denotes We now provide a common mechanism of ERK1 and ERK2 activation for the regulation of IL-10 production in Th1, Th2, and Th17 cells, although each subset differentiates along a distinct and subset-specific transcriptional pathway.
T14220 27636-27806 Sentence denotes This reinforces the fact that IL-10 is not a Th cell-subset-specific cytokine, but instead is produced in a tightly regulated fashion during each differentiation pathway.
T14221 27807-27983 Sentence denotes Of note, a role for ERK1 and ERK2 activation in the induction of IL-10 production has already been described for macrophages and DC (Agrawal et al., 2006; Hacker et al., 1999).
T14222 27984-28249 Sentence denotes Differential transcriptional regulation of IL-10 in Th1 and Th2 cells has been suggested (Chang et al., 2007; Wang et al., 2005), and extensive histone acetylation of the IL-10 gene is detectable in fully polarized Th2 cells, but not Th1 cells (Chang et al., 2007).
T14223 28250-28546 Sentence denotes We provide evidence that IL-10 is produced in canonical Th1 cells and that its expression correlates with the expression of T-bet and the highest IFN-γ production, in keeping with our observations that high-dose antigen stimulation and IL-12 signaling are required for IL-10 and IFN-γ expression.
T14224 28547-28853 Sentence denotes It has also been shown that maintenance of IL-10 expression is conditional on IL-12 or IL-4 unless the IL-10 gene is imprinted by GATA-3 (Chang et al., 2007), which can remodel the IL-10 locus, thus explaining the highest amounts of IL-10 produced by Th2 cells (Chang et al., 2007; Shoemaker et al., 2006).
T14225 28854-29052 Sentence denotes We show here that high antigen dose and IL-12 drastically downregulate Gata-3 expression, suggesting that additional factors are in place to induce IL-10 expression in Th1 cells, albeit transiently.
T14226 29053-29200 Sentence denotes Expression of c-maf was greatly diminished by high antigen doses in T cells and yet was unexpectedly maintained by IL-12 and present in Th17 cells.
T14227 29201-29505 Sentence denotes That c-maf expression is common to IL-10-producing Th1, Th2, and Th17 cells and, like IL-10, is dependent on ERK activation in Th1 and Th17 cells for its expression is of interest because c-Maf has been shown to be an essential transcription factor for IL-10 expression in macrophages (Cao et al., 2005).
T14228 29506-29686 Sentence denotes In summary, we show that although Th1, Th2, and Th17 CD4+ T cell subsets differentiate along distinct signaling and transcriptional pathways, they can all be induced to make IL-10.
T14229 29687-29774 Sentence denotes ERK1 and ERK2 activation is required for IL-10 production by all these Th cell subsets.
T1 0-148 Sentence denotes Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose
T2 151-159 Sentence denotes Abstract
T3 160-167 Sentence denotes Summary
T4 168-274 Sentence denotes CD4+ T cells producing interleukin-10 (IL-10) and interferon-γ (IFN-γ) are reported in chronic infections.
T5 275-380 Sentence denotes However, the signals that direct the development of IL-10-producing T helper 1 (Th1) cells are undefined.
T6 381-592 Sentence denotes We showed that development of IL-10-producing Th1 cells required high T cell receptor (TCR) ligation, sustained ERK1 and ERK2 MAP kinases phosphorylation, and IL-12-induced STAT4 transcription factor activation.
T7 593-798 Sentence denotes Repeated TCR triggering led to enhanced IL-10 production by Th1 cells, and continued IL-12 action and high-dose TCR signaling were required for the development and maintenance of IL-10-producing Th1 cells.
T8 799-1001 Sentence denotes Although Th1, Th2, and Th17 cells require the activation of distinct STATs for their differentiation, activation of ERK1 and ERK2 was a common requirement for production of IL-10 by all Th cell subsets.
T9 1002-1057 Sentence denotes IL-10 expression also correlated with c-maf expression.
T10 1058-1238 Sentence denotes Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production.
T11 1240-1252 Sentence denotes Introduction
T12 1253-1409 Sentence denotes Interleukin-10 (IL-10) is a cytokine with broad anti-inflammatory properties that inhibits macrophage and dendritic cell (DC) function (Moore et al., 2001).
T13 1410-1686 Sentence denotes IL-10 limits the immune and inflammatory responses to pathogens and gut flora and prevents damage to the host (Moore et al., 2001; O'Garra and Vieira, 2004), but when dysregulated may result in chronic infection (Brooks et al., 2006; Ejrnaes et al., 2006; Moore et al., 2001).
T14 1687-2228 Sentence denotes IL-10 is expressed by T helper 2 (Th2) cells, B cells, DCs, and macrophages (Moore et al., 2001), and also by Th1 cells (Anderson et al., 2007; Assenmacher et al., 1994; Del Prete et al., 1993; Gerosa et al., 1996; Jankovic et al., 2007; Pohl-Koppe et al., 1998) and (reviewed in O'Garra and Vieira, 2007; Trinchieri, 2007), certain regulatory (Treg) T cells (Moore et al., 2001; O'Garra and Vieira, 2004; Roncarolo et al., 2006), and Th17 cells (Awasthi et al., 2007; Fitzgerald et al., 2007; McGeachy et al., 2007; Stumhofer et al., 2007).
T15 2229-2539 Sentence denotes In vitro human CD4+ and CD8+ T cell clones, or mouse CD4+ T cells that produce both interferon-γ (IFN-γ) and IL-10, can be differentiated by T cell receptor (TCR)-stimulation in the presence of IL-12 (Chang et al., 2007; Gerosa et al., 1996; Jeannin et al., 1996; Meyaard et al., 1996; Windhagen et al., 1996).
T16 2540-2719 Sentence denotes Furthermore, Th1 cell clones coproducing IFN-γ and IL-10 have been isolated from bronchoalveolar lavage (BAL) of active pulmonary tuberculosis (TB) patients (Gerosa et al., 1999).
T17 2720-3033 Sentence denotes IL-10 production by Th1 cells was also reported in animals infected with Toxoplasma gondii (Jankovic et al., 2002; Shaw et al., 2006) or with Leishmania major (Anderson et al., 2007) and shown to be required for regulation of the immune response in these infections (Anderson et al., 2007; Jankovic et al., 2007).
T18 3034-3297 Sentence denotes The relative amounts of IL-10 and IFN-γ produced by Th1 cells may influence the balance between clearance and persistent infection with certain pathogens (Moore et al., 2001; Trinchieri, 2007), thus determining whether chronic infection or immunopathology ensues.
T19 3298-3460 Sentence denotes Th1, Th2, and Th17 cell responses differentiate along distinct signaling pathways (Glimcher and Murphy, 2000; Ivanov et al., 2007; Stockinger and Veldhoen, 2007).
T20 3461-3852 Sentence denotes Th1 cell development requires signal transducer and activator of transcription (STAT)1 activation, induced by type I IFN or IFN-γ, the transcription factor T-box 21 (T-bet), and IL-12-induced STAT4 signaling, which can couple with IL-18-induced IRAK and NF-κB transcription factors to drive the high amounts of IFN-γ required to eradicate intracellular pathogens (Glimcher and Murphy, 2000).
T21 3853-4026 Sentence denotes Th2 cell development, with expression of IL-4, IL-5, and IL-13, requires IL-4, STAT6, and the transcription factor GATA binding protein (GATA)-3 (Glimcher and Murphy, 2000).
T22 4027-4201 Sentence denotes The development of Th17 cells requires IL-6, TGF-β, and the STAT3-dependent expression of the transcription factor RORγt (Ivanov et al., 2007; Stockinger and Veldhoen, 2007).
T23 4202-4347 Sentence denotes Th1 and Th2 cell responses can also be induced by varying the dose of antigen presented to the naive T cell by the antigen-presenting cell (APC).
T24 4348-4770 Sentence denotes Whereas high doses of antigen, with sustained TCR signaling and extracellular-signal regulated (ERK) mitogen-activated protein kinase (MAPK) phosphorylation, result in Th1 cells producing IFN-γ via an IL-12-independent mechanism, low doses of antigen, with transient ERK1 and ERK2 activation, favor Th2 responses and IL-4 secretion (Constant et al., 1995; Hosken et al., 1995; Jorritsma et al., 2003; Yamane et al., 2005).
T25 4771-5179 Sentence denotes Because Th1 and Th2 cells cross regulate each other's development and function and can suppress Th17 cell responses, and all differentiate along distinct signaling pathways (Glimcher and Murphy, 2000; Stockinger and Veldhoen, 2007), IL-10 produced by all these Th cells may thus act as a feedback regulator to control the pathology associated with an overexuberant, albeit efficacious, inflammatory response.
T26 5180-5302 Sentence denotes Whether IL-10 production by these different Th cell subsets is induced by independent and/or common mechanisms is unknown.
T27 5303-5529 Sentence denotes Here, we showed that in vitro differentiation of IL-10-producing Th1 cells from naive CD4+ T cells required IL-12-induced STAT4 signaling, strong TCR activation (high antigen dose), and sustained ERK1 and ERK2 phosphorylation.
T28 5530-5662 Sentence denotes Furthermore, we showed that activation of ERK1 and ERK2 is a requirement for production of IL-10 by Th1, Th2, and Th17 cell subsets.
T29 5663-5889 Sentence denotes This common but highly regulated pathway for IL-10 induction and maintenance ensures its function as a feedback loop to control damage to the host and also allows a protective response to ensue as opposed to chronic infection.
T30 5891-5898 Sentence denotes Results
T31 5900-5983 Sentence denotes IL-12 and High Doses of Antigen Induce the Development of Th1 Cells Producing IL-10
T32 5984-6200 Sentence denotes To study the differentiation of Th1 cells coproducing IFN-γ and IL-10, we cultured purified TCR-transgenic DO11.10 naive CD4+ T cells with purified DCs as APCs and increasing doses of ovalbumin peptide 323-339 (OVA).
T33 6201-6396 Sentence denotes Culture with high doses of antigen for 7 days gave rise to Th1 cells expressing IFN-γ upon restimulation (Constant et al., 1995; Hosken et al., 1995), but not IL-10 (Figure S1A available online).
T34 6397-6563 Sentence denotes Culture with low antigen doses under the same conditions led to the differentiation of Th2 cells, which expressed both IL-4 and IL-10 upon restimulation (Figure S1A).
T35 6564-6835 Sentence denotes Culture of naive CD4+ T cells in an APC-free system by stimulation with anti-CD3 and anti-CD28 antibodies in the presence of IL-12 resulted in IFN-γ-producing Th1 cells, a proportion of which coproduced IL-10, as did Th2 cells resulting from culture in IL-4 (Figure S1B).
T36 6836-7111 Sentence denotes To investigate whether the lack of IL-10 produced by Th1 cells resulted from inhibition of IL-10 production by DCs and high antigen dose or alternatively required IL-12, we cultured naive CD4+ T cells with increasing doses of antigen presented by DC in the presence of IL-12.
T37 7112-7364 Sentence denotes At low doses of antigen, IL-12 abrogated the development of Th2 cells and induced IFN-γ expression but only low levels of IL-10 expression, suggesting that IL-12 per se was not sufficient to induce significant IL-10 production in Th1 cells (Figure 1A).
T38 7365-7583 Sentence denotes Strikingly, as the antigen dose was increased, Th1 populations driven with IL-12 now contained higher numbers of IL-10-producing cells (Figure 1A) and produced more IL-10 protein upon restimulation (Figures 1A and 1B).
T39 7584-7681 Sentence denotes Thus, the development of Th1 cells producing IL-10 required both IL-12 and high doses of antigen.
T40 7682-7803 Sentence denotes Th1 cells differentiated to produce large amounts of IL-10 and IFN-γ and lost their capacity to produce IL-2 (Figure 1B).
T41 7804-8057 Sentence denotes Because the presence of IL-12 reduced the proliferation of CD4+ T cells at both high and low antigen doses (Table S1), and only the former showed IL-10 production, the development of high IL-10-producing cells is most likely not related to limited IL-2.
T42 8058-8377 Sentence denotes Naive CD4+ T cells from DO11.10/recombination-activating gene 1 (Rag1)-deficient animals, cultured with high doses of antigen in the presence of IL-12, also resulted in IL-10 expression by Th1 cells, showing that this expression was not dependent on the presence of effector or memory T cells or Treg cells (Figure S2).
T43 8378-8583 Sentence denotes Although it has been suggested that TGF-β can induce IL-10 in CD4+ T cells (Kitani et al., 2003; Schiott et al., 2000), we found that in developing Th1 and Th2 cells this was not the case (data not shown).
T44 8584-8686 Sentence denotes In fact, neutralization of TGF-β led to increased IL-10 production by both T cell subsets (Figure S3).
T45 8687-8905 Sentence denotes Thus, the development of IL-10-producing Th1 cells only depended on the presence of IL-12 together with high antigen dose and not on other soluble factors such as IL-2 or TGF-β or on the presence of other T cell types.
T46 8907-9001 Sentence denotes IL-10 Production by Th1 Cells Is Dependent on STAT4 but Not on STAT6, IFN-γ, or IL-4 Signaling
T47 9002-9203 Sentence denotes To further elucidate the mechanisms required for the development of Th1 cells producing IL-10, we investigated the role of STAT4, one of the signaling pathways activated by IL-12 (Murphy et al., 2000).
T48 9204-9319 Sentence denotes Naive CD4+ D011.10 T cells deficient in STAT4 (Ouyang et al., 1998) were cultured in the presence of IL-12 and OVA.
T49 9320-9454 Sentence denotes Again, IL-10-producing Th1 cells were differentiated at the high antigen dose in the presence of IL-12 in DO11.10 T cells (Figure 2A).
T50 9455-9740 Sentence denotes In contrast, in the absence of STAT4, the percentage of cells expressing IFN-γ was dramatically diminished as expected and resulted in an increase in the percentage of cells expressing IL-4, but not IL-10 (Figure 2A), suggesting that STAT4 contributes to IL-10 expression by Th1 cells.
T51 9741-10016 Sentence denotes Because IL-10 expression is associated with an IL-4-induced Th2 cell phenotype, we investigated whether the differentiation of the IL-10-producing Th1 cells depended on signaling through the IL-4 receptor via STAT6 activation (Glimcher and Murphy, 2000; Murphy et al., 2000).
T52 10017-10147 Sentence denotes The absence of STAT6 did not impair the differentiation of IL-10-producing Th1 cells in the presence of IL-12 and OVA (Figure 2A).
T53 10148-10349 Sentence denotes In fact, a higher percentage of STAT6-deficient cells compared with WT cells produced both IL-10 and IFN-γ (Figure 2A), which may be the result of the loss of Th2 cell control over a Th1 cell response.
T54 10350-10494 Sentence denotes As expected, lack of STAT6 abrogated both IL-4 and IL-10 production by T cells developed with IL-4 or with low antigen dose (Figures 2B and 2C).
T55 10495-10624 Sentence denotes However, in the absence of STAT4 signaling, IL-10 and IL-4 production by Th2 cells was if anything increased (Figures 2B and 2C).
T56 10625-10783 Sentence denotes Thus, in contrast to what was observed under Th1 conditions, IL-10 expression by Th2 cells depended on STAT6, but not on STAT4, signaling (Figures 2B and 2C).
T57 10784-11069 Sentence denotes To investigate whether the inability of STAT4-deficient T cells to produce IL-10 might be due to the absence of IFN-γ, as suggested before (Shaw et al., 2006), we differentiated DO11.10 or DO11.10 IFN-γ-deficient naive CD4+ T cells in the presence of IL-12 and increasing doses of OVA.
T58 11070-11263 Sentence denotes The secretion of IL-10 as induced by high antigen dose, and IL-12 was not affected by an absence of IFN-γ (Figure 2D), showing that the expression of IL-10 by Th1 cells is independent of IFN-γ.
T59 11264-11363 Sentence denotes In the absence of IFN-γ, we observed an increase in the secreted IL-4 as expected (data not shown).
T60 11364-11567 Sentence denotes We also tested for any potential role of IL-4 in the development of Th1 cells producing IL-10 by culturing DO11.10 or DO11.10 IL-4-deficient naive CD4+ T cells with IL-12 and increasing doses of antigen.
T61 11568-11781 Sentence denotes As observed in the absence of STAT6 (Figure 2A), IL-4 deficiency had no effect on the development of Th1 cells producing IL-10 (Figure 2E), but compromised the development of Th2 cells producing IL-10 (Figure 2F).
T62 11782-12038 Sentence denotes Thus, our data suggested that IL-10 production by Th1 or Th2 cells was dependent on the specific signaling pathways required for their differentiation, given that STAT4 is required for the induction of IL-10 production by Th1 cells and STAT6 for Th2 cells.
T63 12040-12137 Sentence denotes High Antigen Doses and STAT4 Are Required for the In Vivo Generation of IL-10-Producing Th1 Cells
T64 12138-12381 Sentence denotes To address the mechanisms regulating IL-10 production by Th1 cells in vivo, we transferred DO11.10 cells into BALB/c recipient mice and immunized the recipients with very high doses of OVA-protein with or without added lipopolysacharide (LPS).
T65 12382-12509 Sentence denotes T cells were recovered from the inguinal lymph nodes 3 days after priming and restimulated in vitro with OVA peptide for 48 hr.
T66 12510-12735 Sentence denotes This in vivo immunization induced IL-10 and IFN-γ production, and the amount of IL-10 production was enhanced by addition of LPS in the immunization (Figure 3A) and with higher doses of OVA (3 μM versus 1 μM, data not shown).
T67 12736-12977 Sentence denotes To test the role of STAT4 and STAT6 signaling in the in vivo development of IL-10-producing Th1 cells, we transferred STAT4- or STAT6-deficient or WT DO11.10 cells into recipient BALB/c mice and immunized with OVA-protein plus LPS as before.
T68 12978-13218 Sentence denotes In vivo expression of both IL-10 and IFN-γ was markedly reduced but not completely abrogated in the absence of STAT4 signaling (Figures 3B and 3C), suggesting the existence of compensatory mechanisms that were absent in the in vitro system.
T69 13219-13406 Sentence denotes Signaling through STAT6 had no effect on IL-10 production by Th1 cells as shown by intracellular cytokine staining (ICS) and by immunoassay in STAT6-deficient T cells (Figures 3B and 3C).
T70 13408-13476 Sentence denotes IL-10 Production Is Maintained by High TCR Signal Strength and IL-12
T71 13477-13635 Sentence denotes We next investigated whether repeated strong TCR activation is a compensatory signal for IL-12-induced STAT4 signaling in the induction of IL-10 in Th1 cells.
T72 13636-13790 Sentence denotes For this, CD4+ T cells were differentiated for 2 consecutive weeks with high antigen doses in the presence or absence of IL-12 throughout (Figures 4A–4D).
T73 13791-13975 Sentence denotes High antigen dose and IL-12 cooperated to induce maximal IL-10 production (Figures 4A and 4B), given that this combination resulted in the highest numbers of IL-10-producing Th1 cells.
T74 13976-14226 Sentence denotes Repeated high antigen dose stimulation in the absence of exogenously added IL-12 resulted in the production of IL-10 by Th1 cells, suggesting that repeated strong TCR triggering may overcome the need for IL-12 for IL-10 induction (Figures 4C and 4D).
T75 14227-14347 Sentence denotes However, IL-10 induction under these conditions was abrogated when IL-12p40-deficient DCs were used as APCs (Figure 4E).
T76 14348-14466 Sentence denotes Thus, IL-12 is essential during both primary and secondary antigenic stimulation for production of IL-10 by Th1 cells.
T77 14467-14790 Sentence denotes To determine the requirements for stability of the IL-10-producing Th1 cells, we differentiated CD4+ T cells for 1 week with high antigen doses with or without IL-12 (Figures 4A and 4C), washed them, and then restimulated them for an additional week with a low antigen dose, in the absence or presence of IL-12 (Figure 4F).
T78 14791-15162 Sentence denotes Th1 cells induced in the first week to produce IL-10 by culture with high antigen doses and IL-12 lost their ability to express IL-10 when recultured with low doses of OVA, which could be compensated for, to some extent, by addition of IL-12 to the secondary cultures (Figure 4F), again suggesting that antigen dose and IL-12 signals cooperate for the induction of IL-10.
T79 15163-15463 Sentence denotes Finally, DO11.10 CD4+ cells that were exposed to low doses of antigen and IL-12 during the primary differentiation phase produced high amounts of IFN-γ but little IL-10, but they could be induced to produce IL-10 when both high antigen dose and IL-12 were present during the recall phase (Figure S4).
T80 15464-15573 Sentence denotes Thus, high antigen dose and IL-12 are required for sustaining the induction of IL-10 production by Th1 cells.
T81 15575-15638 Sentence denotes IL-10 Production by Th1 Cells Requires ERK1 and ERK2 Activation
T82 15639-15824 Sentence denotes Our data showed that the maintenance of IL-10 induction in Th1 cells required stimulation with high antigen dose, which to some extent could be compensated for by the addition of IL-12.
T83 15825-16150 Sentence denotes Signaling through the TCR with high doses of antigen induced stronger ERK1 and ERK2 activation than that induced by low antigen dose, not only in naive CD4+ T cells (data not shown) as previously demonstrated (Jorritsma et al., 2003) but also in CD4+ T cells restimulated with the same high and low antigen doses (Figure 5A).
T84 16151-16502 Sentence denotes Although the apparent peak and amount of ERK1 and ERK2 activation varied slightly between experiments, a consistent finding was that high antigen dose differentiated Th1 cells always showed enhanced and prolonged ERK1 and ERK2 activation in the presence of IL-12, regardless of whether they were restimulated with high or low antigen dose (Figure 5B).
T85 16503-16687 Sentence denotes We then investigated whether ERK1 and ERK2 activation was required for the induction of IL-10 in Th1 cells by using U0126 (Figure 5C), a compound that blocks downstream ERK activation.
T86 16688-16901 Sentence denotes To ensure that only T cell signaling was being affected by U0126, we used an APC-free system in which the T cells were differentiated in the presence of increasing doses of anti-CD3 and a constant amount of IL-12.
T87 16902-17080 Sentence denotes As in the APC-driven cultures, stronger TCR stimulation together with IL-12 led to higher percentages of cells producing both IL-10 and IFN-γ after 1 week of culture (Figure 5C).
T88 17081-17186 Sentence denotes Addition of U0126 to the cultures abrogated the production of IL-10 at all doses of anti-CD3 (Figure 5C).
T89 17187-17550 Sentence denotes Because U0126 inhibits the MEK5-catalyzed activation of ERK5, as well as the MEK1- and MEK2-catalyzed activation of ERK1 and ERK2 (Bain et al., 2007; Mody et al., 2001), we also used the more specific, structurally unrelated MEK1 and MEK2 inhibitor PD184352 at concentrations in which it inhibits MEK1 and MEK2 but not MEK5 (Bain et al., 2007; Mody et al., 2001).
T90 17551-17676 Sentence denotes PD184352 caused a similar inhibition of IL-10 production by Th1 cells in a dose-dependent fashion (Figure 5D and Figure S5A).
T91 17677-17885 Sentence denotes Upon addition of inhibitors to other signaling pathways, including a p38 MAPK inhibitor, SB203580, or the GSK3β inhibitor, CT99021 (Bain et al., 2007), no effect on IL-10 production was observed (Figure S5B).
T92 17886-18078 Sentence denotes Our data thus suggested that IL-10 production by Th1 cells in response to high antigen dose and IL-12 requires ERK1 and ERK2 signaling, but not the activation of the p38 or the GSK3β pathways.
T93 18080-18157 Sentence denotes IL-10 Production by Th2 and Th17 Cells Also Requires ERK1 and ERK2 Activation
T94 18158-18476 Sentence denotes To address whether IL-10 production by Th2 and Th17 cells was also dependent on ERK1 and ERK2 activation, we differentiated these cells with anti-CD3 and anti-CD28 in the absence of APCs (Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006), in the presence or absence of the MEK inhibitor (PD184352).
T95 18477-18748 Sentence denotes We showed that ERK1 and ERK2 activation is a common pathway required for induction of IL-10 in different Th cell subsets because IL-10 production by both Th2 and Th17 cells was markedly inhibited in the presence of the MEK inhibitor (PD184352) (Figure 5D and Figure S5B).
T96 18749-18878 Sentence denotes In contrast, inhibitors of p38 MAPK or of GSK-3β activation did not affect the expression of IL-10 by these subsets (Figure S5B).
T97 18879-19029 Sentence denotes Activation of the ERK1 and ERK2 signaling pathway is therefore a common requirement for the induction of IL-10 production by Th1, Th2, and Th17 cells.
T98 19031-19108 Sentence denotes c-maf Expression Correlates with IL-10 Production in Th1, Th2, and Th17 Cells
T99 19109-19391 Sentence denotes To investigate further the downstream factors involved in regulating IL-10 production, we differentiated DO11.10 CD4+ T cells with increasing doses of OVA, in the presence or absence of IL-12, and quantified the expression of cytokines and transcription factors by real-time RT-PCR.
T100 19392-19514 Sentence denotes Low-dose antigen resulted in transcription of Il4 and this was abrogated by both high antigen doses and IL-12 (Figure 6A).
T101 19515-19723 Sentence denotes A low amount of transcription of Ifnγ was induced by IL-12 when cells were differentiated with low antigen dose, but this effect of IL-12 was markedly upregulated with increasing doses of antigen (Figure 6A).
T102 19724-19932 Sentence denotes A low amount of Il10 transcription was observed at low doses of antigen accompanying Il4 expression (Th2 cell response), and this was abrogated by increased doses of antigen as was Il4 expression (Figure 6A).
T103 19933-20073 Sentence denotes At low doses of antigen, IL-12 had little effect to increase IL-10 mRNA expression (Figure 6A) in keeping with the protein data (Figure 1A).
T104 20074-20253 Sentence denotes However, IL-12 induced a high amount of Il10 transcription as well as Ifnγ expression with increased antigen doses (Figure 6A), again in keeping with the protein data (Figure 1A).
T105 20254-20419 Sentence denotes CD4+ T cells differentiated with increasing doses of antigen did not express high amounts of Tbx-21 (T-bet) mRNA, unless they were cocultured with IL-12 (Figure 6B).
T106 20420-20679 Sentence denotes In contrast, high amounts of GATA-3 mRNA expression were only observed under Th2 cell differentiation conditions (low-dose antigen) (Figure 6B), and this expression was markedly downregulated by both increasing antigen dose and coculture in IL-12 (Figure 6B).
T107 20680-20895 Sentence denotes Differentiation of T cells under low antigen dose led to expression of c-maf, in keeping with the Th2 cell profile (Ho et al., 1996), which was almost completely abrogated by increasing doses of antigen (Figure 6B).
T108 20896-21006 Sentence denotes Interestingly, IL-12 sustained the high expression of c-Maf mRNA even at the highest antigen dose (Figure 6B).
T109 21007-21098 Sentence denotes Moreover, IL-12 maintenance of c-maf expression required STAT4 activation (data not shown).
T110 21099-21294 Sentence denotes In Th17 cells that expressed IL-17a as well as IL-10 mRNA (Figure 6C), T-bet and GATA-3 mRNA were undetectable (data not shown), whereas that of ROR-γt was high (Figure 6C) (Ivanov et al., 2007).
T111 21295-21607 Sentence denotes Th17 cells also expressed high amounts of c-maf (Figure 6C), confirming a recent report (Bauquet et al., 2009). c-Maf is therefore expressed in all IL-10-expressing T cell populations tested (Figures 6B and 6C) and may not be just a Th2 cell-specific transcription factor as originally thought (Ho et al., 1996).
T112 21608-21829 Sentence denotes We showed also that like Il10 expression, c-maf expression was inhibited in Th1 and Th17 cells in the presence of the MEK1 and MEK2 inhibitor (PD184352), whereas T-bet and RORγt expression was hardly affected (Figure 6D).
T113 21831-21841 Sentence denotes Discussion
T114 21842-22038 Sentence denotes IL-10 expression by cells of the innate and adaptive immune systems reflects the importance of this cytokine in the tight regulation of the immune response, to minimize pathology during infection.
T115 22039-22154 Sentence denotes IL-10 expression by Th1 cells has been reported to regulate the immune response in leishmaniasis and toxoplasmosis.
T116 22155-22256 Sentence denotes However, in many situations, IL-10 is not produced by Th1 cells in response to antigenic stimulation.
T117 22257-22380 Sentence denotes Our goal was to address the molecular signals that determine whether Th1 cells develop to produce IL-10 (Trinchieri, 2007).
T118 22381-22530 Sentence denotes Here, we showed that Th1 cells required high-antigen-dose-induced ERK1 and ERK2 phosphorylation and IL-12-induced STAT-4 activation to produce IL-10.
T119 22531-22899 Sentence denotes Our findings that ERK1 and ERK2 activation was a common pathway required for the production of IL-10 by Th1, Th2, and Th17 cell subsets, which differentiate along distinct pathways, such that IL-10 provides a highly regulated feedback loop to avoid the extremes of excessive inflammation or chronic infections and also allow a protective response to diverse pathogens.
T120 22900-23113 Sentence denotes In certain viral or parasitic infections (Anderson et al., 2007; Brooks et al., 2006; Ejrnaes et al., 2006), high amounts of stimulation may lead to the chronic nonhealing infection shown to be regulated by IL-10.
T121 23114-23301 Sentence denotes During the course of infection, after initial triggering with antigen, T cells migrate to the tissue encountering high doses of antigen and factors produced by the innate immune response.
T122 23302-23554 Sentence denotes Under these conditions, we speculate that Th1 cells will be induced to express high amounts of IL-10, in keeping with reports that IL-10-producing Th1 cells were found in CD4+ clones isolated from BAL but not blood of TB patients (Gerosa et al., 1999).
T123 23555-23920 Sentence denotes Similarly, the immune response to a clinical isolate of L. major, which produces heavily infected nonhealing lesions, was found to be regulated by IL-10 derived from Foxp3− Th1 cells that coproduce IL-10 and IFN-γ (Anderson et al., 2007), and the immune response during T. gondii infection was found also to be regulated by Foxp3− Th1 cells (Jankovic et al., 2007).
T124 23921-24298 Sentence denotes It is likely that IL-10 production by Th1 cells is evoked under conditions of high inflammation and antigenic stimulation, whereas regulatory CD4+ T cells producing IL-10 may operate to regulate the immune response under conditions in which the pathogen is clinically controlled, such as in infection with L. major (Friedlin strain) (Belkaid et al., 2002; Suffia et al., 2006).
T125 24299-24603 Sentence denotes We now also reported that CD4+ T cells cultured with high antigen dose and IL-12 differentiate into canonical Th1 effector cells, which, in addition to expressing large amounts of IFN-γ and IL-10, lose their IL-2 expression as described before in certain chronic infection models (Sallusto et al., 2004).
T126 24604-24790 Sentence denotes Our demonstration that loss of IL-2 is accompanied by production of IL-10 offers potential additional mechanisms whereby effector T cell responses may be dampened during chronic disease.
T127 24791-24992 Sentence denotes Using an in vivo transfer model of DO11.10 TCR transgenic cells (Castro et al., 2000), we showed that IL-10-producing Th1 cells were differentiated in the presence of high doses of OVA protein and LPS.
T128 24993-25187 Sentence denotes We showed here that this induction of IL-10 in Th1 cells in vivo was markedly, but not totally, reduced in STAT4-deficient T cells as observed during T. gondii infection (Jankovic et al., 2002).
T129 25188-25414 Sentence denotes A high antigenic activation during T. gondii infection or high antigen doses delivered in the presence of LPS, as seen in our system, may compensate for an absolute requirement for IL-12 in the induction of IL-10 by Th1 cells.
T130 25415-25579 Sentence denotes In our in vitro system, repeated stimulation of Th1 cells with high antigen doses allowed the development of Th1 cells producing IL-10 in an IL-12-dependent manner.
T131 25580-25733 Sentence denotes IL-10 production by Th1 cells induced by high antigen dose and IL-12 was independent of IFN-γ, in keeping with previous findings (Jankovic et al., 2002).
T132 25734-25886 Sentence denotes However, a role for IFN-γ in mediating IL-10 reactivation by Th1 cells during secondary infection with T. gondii has been suggested (Shaw et al., 2006).
T133 25887-26123 Sentence denotes We have found that CD4+ T cells exposed to a high dose of antigen do not express IL-10 upon restimulation, but can be induced to produce IL-10 upon re-exposure to a high dose of antigen in the recall phase in the absence of added IL-12.
T134 26124-26203 Sentence denotes However, this is dependent on the induction of IL-12 by antigen-presenting DCs.
T135 26204-26371 Sentence denotes The combination of both high antigen dose and IL-12 resulted in the highest levels of IL-10 production and correlated with the high levels of ERK1 and ERK2 activation.
T136 26372-26589 Sentence denotes The increased expression of IFN-γ observed during the secondary phase will induce increased IL-12 production by DCs and suggests that repeated high-level TCR activation feeds back to upregulate IL-12 production by DC.
T137 26590-26800 Sentence denotes It is thus likely that in T. gondii infection in vivo (Shaw et al., 2006), the requirement for IFN-γ to induce IL-10, was for feedback upregulation of IL-12 by DCs, which in turn induced IL-10 in the Th1 cells.
T138 26801-27038 Sentence denotes Although IL-10 may be differentially regulated in Th1 and Th2 cells as has been reported (Chang et al., 2007; Wang et al., 2005), some studies suggest the existence of common pathways, but the molecular basis for these is as yet unclear.
T139 27039-27293 Sentence denotes Costimulatory OX-40 signals have been shown to negatively regulate IL-10 production (Ito et al., 2005) both in Th1 and Th2 cells, whereas ICOS signaling has been suggested to induce IL-10 (Ito et al., 2007; Witsch et al., 2002) in both Th1 and Th2 cells.
T140 27294-27407 Sentence denotes However, in some cases, ICOS signaling also regulates IL-4 production and Th2 responses (Greenwald et al., 2005).
T141 27408-27635 Sentence denotes We now provide a common mechanism of ERK1 and ERK2 activation for the regulation of IL-10 production in Th1, Th2, and Th17 cells, although each subset differentiates along a distinct and subset-specific transcriptional pathway.
T142 27636-27806 Sentence denotes This reinforces the fact that IL-10 is not a Th cell-subset-specific cytokine, but instead is produced in a tightly regulated fashion during each differentiation pathway.
T143 27807-27983 Sentence denotes Of note, a role for ERK1 and ERK2 activation in the induction of IL-10 production has already been described for macrophages and DC (Agrawal et al., 2006; Hacker et al., 1999).
T144 27984-28249 Sentence denotes Differential transcriptional regulation of IL-10 in Th1 and Th2 cells has been suggested (Chang et al., 2007; Wang et al., 2005), and extensive histone acetylation of the IL-10 gene is detectable in fully polarized Th2 cells, but not Th1 cells (Chang et al., 2007).
T145 28250-28546 Sentence denotes We provide evidence that IL-10 is produced in canonical Th1 cells and that its expression correlates with the expression of T-bet and the highest IFN-γ production, in keeping with our observations that high-dose antigen stimulation and IL-12 signaling are required for IL-10 and IFN-γ expression.
T146 28547-28853 Sentence denotes It has also been shown that maintenance of IL-10 expression is conditional on IL-12 or IL-4 unless the IL-10 gene is imprinted by GATA-3 (Chang et al., 2007), which can remodel the IL-10 locus, thus explaining the highest amounts of IL-10 produced by Th2 cells (Chang et al., 2007; Shoemaker et al., 2006).
T147 28854-29052 Sentence denotes We show here that high antigen dose and IL-12 drastically downregulate Gata-3 expression, suggesting that additional factors are in place to induce IL-10 expression in Th1 cells, albeit transiently.
T148 29053-29200 Sentence denotes Expression of c-maf was greatly diminished by high antigen doses in T cells and yet was unexpectedly maintained by IL-12 and present in Th17 cells.
T149 29201-29505 Sentence denotes That c-maf expression is common to IL-10-producing Th1, Th2, and Th17 cells and, like IL-10, is dependent on ERK activation in Th1 and Th17 cells for its expression is of interest because c-Maf has been shown to be an essential transcription factor for IL-10 expression in macrophages (Cao et al., 2005).
T150 29506-29686 Sentence denotes In summary, we show that although Th1, Th2, and Th17 CD4+ T cell subsets differentiate along distinct signaling and transcriptional pathways, they can all be induced to make IL-10.
T151 29687-29774 Sentence denotes ERK1 and ERK2 activation is required for IL-10 production by all these Th cell subsets.
T152 29775-29992 Sentence denotes With regard to the expression of IL-10 by Th1 cells, our data provide a mechanism for how IL-10 expression is induced and then amplified and regulated by the levels of antigen and IL-12 encountered in the environment.
T153 29993-30290 Sentence denotes This provides a mechanism whereby a Th1 cell responds to extrinsic signals, reflecting increased inflammation in the tissue, to tightly regulate the production of IL-10 so as to allow a protective response to eradicate a pathogen with minimal damage to the host and also prevent chronic infection.
T154 30291-30540 Sentence denotes Moreover, our findings have important implications for the regulation of IL-10 production during an inflammatory Th1 response in infection and may be of relevance for the design of vaccines and for strategies in immunotherapy in infectious diseases.
T155 30542-30565 Sentence denotes Experimental Procedures
T156 30567-30614 Sentence denotes Mice, Cytokines, Antibodies, and Other Reagents
T157 30615-31043 Sentence denotes BALB/c DO11.10 mice transgenic for OVA-specific TCR WT or crossed back with Rag1-, IL-4-, IFN-γ-, STAT4-, and STAT6-deficient mice were used as a source of antigen-specific T cells (Murphy et al., 1990; Ouyang et al., 1998; Shoemaker et al., 2006) and were bred and maintained under SPF conditions at the NIMR, London, Home Office, UK, Animals (Scientific Procedures) Act 1986 or at the Washington University School of Medicine.
T158 31044-31195 Sentence denotes Female mice were used at 8–12 weeks old, and animal protocols were approved according to the Animals (Scientific Procedures) Act 1986, Home Office, UK.
T159 31196-31432 Sentence denotes Reagents, including antibodies for T cell and DC preparation, purification and culture, media, cytokines, and cytokine mAbs have been described (Hosken et al., 1995; Shoemaker et al., 2006; Veldhoen et al., 2009; Veldhoen et al., 2006).
T160 31433-31612 Sentence denotes LPS (S. minnesota) was from Alexis, chicken ovalbumin protein (OVA protein) was from from Sigma-Aldrich, and ovalbumin peptide323-339 (OVA) (endotoxin-free) was from Biosynthesis.
T161 31613-31649 Sentence denotes U0126 was from BioMol International.
T162 31650-31756 Sentence denotes PD184352 (MEK inhibitors), SB203580 (p38 inhibitor), and CT99021 (GSK3β inhibitor) were kind gifts from P.
T163 31757-31803 Sentence denotes Cohen and N. Shpiro, University of Dundee, UK.
T164 31805-31902 Sentence denotes Isolation of CD4+ T Cells and of Splenic DC and Cell Culture for T Cell Phenotype Differentiation
T165 31903-32077 Sentence denotes T cells were sorted for CD4+CD62Lhi, CD4+CD62LhiCD25−, or CD4+CD44loCD25− to >98% on a Moflo cytometer (Cytomation) as before (Shoemaker et al., 2006; Veldhoen et al., 2009).
T166 32078-32201 Sentence denotes In most cases, experiments were reproduced with each type of purified CD4+ T cell population with similar results obtained.
T167 32202-32328 Sentence denotes Splenic DCs were prepared as described (Hosken et al., 1995), and sort purified CD11c+ cells were added to the T cell culture.
T168 32329-32561 Sentence denotes Purified DO11.10 CD4+ T cells (1 × 105 cells/ml) were cultured as before (Hosken et al., 1995), in a total volume of 1 ml cRPMI medium in a 48-well plate, with splenic DCs (2 × 104 cells/ml), and varying amounts of OVA and of IL-12.
T169 32562-32831 Sentence denotes APC-independent differentiation of naive CD4+ T cells into Th1 and Th2 cells used stimulation with anti-CD3 and anti-CD28 and appropriate cytokine conditions, and control Th1 and Th2 cells were cultured as described before (Hosken et al., 1995; Shoemaker et al., 2006).
T170 32832-32915 Sentence denotes Culture conditions for Th17 cells were as described before (Veldhoen et al., 2006).
T171 32916-33140 Sentence denotes Importantly, Th1 and Th2 cells could be differentiated in cRPMI or IMDM (Hosken et al., 1995; Shoemaker et al., 2006; Veldhoen et al., 2006), but Th17 cells were only differentiated optimally in IMDM (Veldhoen et al., 2009).
T172 33141-33302 Sentence denotes When indicated, U0126 or PD184352 (MEK inhibitors), SB203580 (p38 inhibitor), CT99021 (GSK3β inhibitor), or a similar amount of DMSO were present in the culture.
T173 33303-33381 Sentence denotes More details of specific culture conditions are provided in Figures S6 and S7.
T174 33383-33418 Sentence denotes Cytokine Detection by ICS and ELISA
T175 33419-33629 Sentence denotes At day 5 or 7, cells were restimulated with immobilized anti-CD3 (2 μg/ml) and anti-CD28 (2 μg/ml) (4 hr with BrefeldinA [10 μg/ml] in the last 2 hr) or with PdBU and Ionomycin (5 hr with BrefeldinA [1 μg/ml]).
T176 33630-33739 Sentence denotes After ICS FACS, data were collected on a FACSCalibur (Becton Dickinson) and analyzed with FlowJo (Tree Star).
T177 33740-33910 Sentence denotes For ELISA, cells were similarly restimulated for 48 hr and supernatant was collected and analyzed for IL-4, IL-10, and IFN-γ as described before (Shoemaker et al., 2006).
T178 33912-33927 Sentence denotes In Vivo Studies
T179 33928-34115 Sentence denotes BALB/c mice were injected intravenously (i.v.) with a red blood cell-depleted single-cell spleen suspension (2.5 × 107 cells) (Castro et al., 2000) from DO11.10 WT or STAT-deficient mice.
T180 34116-34215 Sentence denotes After 48 hr, they were injected subcutaneously with PBS or with OVA protein (5 mg) plus LPS (5 μg).
T181 34216-34266 Sentence denotes The inguinal lymph nodes were removed 48 hr later.
T182 34267-34404 Sentence denotes A single-cell suspension (1 × 106 cells) was restimulated for 24 or 48 hr with 1 μM or 3 μM of OVA and with BrefeldinA for the last 6 hr.
T183 34405-34501 Sentence denotes Half of the supernatant was removed before the addition of BrefeldinA for use in an ELISA assay.
T184 34502-34545 Sentence denotes The cells were fixed and stained as before.
T185 34546-34691 Sentence denotes Those positive for KJ1-26-Bio and for CD4-PerCP were gated, and IFN-γ and IL-10 staining was examined for this population and analyzed as before.
T186 34693-34722 Sentence denotes Real-Time Quantitative RT-PCR
T187 34723-34866 Sentence denotes Cells were harvested and restimulated in the presence of immobilized anti-CD3 (2 μg/ml) plus anti-CD28 (2 μg/ml) for 3 hr or immediately lysed.
T188 34867-35047 Sentence denotes RNA was extracted and reverse-transcribed and cDNA was analyzed for the expression of cytokines and transcription factors by real-time PCR assay as before (Shoemaker et al., 2006).
T189 35048-35237 Sentence denotes Target gene mRNA expression was quantified either with SYBR Green (Applied Biosystems) or with Master Mix (Applied Biosystems) and normalized to ubiquitin or HPRT mRNA levels, respectively.
T190 35239-35253 Sentence denotes Immunoblotting
T191 35254-35386 Sentence denotes Differentiated CD4+ T cells were rested for 5 hr in 1% FCS-containing medium and restimulated as described for specific experiments.
T192 35387-35566 Sentence denotes Cell lysates were prepared, equal amounts of protein were separated by SDS-PAGE, and phosphorylated or total ERK and actin were detected as described before (Beinke et al., 2004).

ICD10

Id Subject Object Predicate Lexical cue
T2225 2670-2682 http://purl.bioontology.org/ontology/ICD10/A15-A19.9 denotes tuberculosis
T17660 22122-22135 http://purl.bioontology.org/ontology/ICD10/B55 denotes leishmaniasis
T17661 22122-22135 http://purl.bioontology.org/ontology/ICD10/B55.9 denotes leishmaniasis
T17662 22140-22153 http://purl.bioontology.org/ontology/ICD10/B58.9 denotes toxoplasmosis
T17663 22140-22153 http://purl.bioontology.org/ontology/ICD10/B58 denotes toxoplasmosis

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T721 0-14 Protein denotes Interleukin-10
T722 15-25 Gene_expression denotes Production
T723 39-47 Positive_regulation denotes Requires
T724 39-47 Positive_regulation denotes Requires
T725 48-62 Protein denotes Interleukin-12
T726 63-70 Positive_regulation denotes Induced
T727 71-76 Protein denotes STAT4
T728 102-105 Protein denotes ERK
T729 117-127 Positive_regulation denotes Activation
T730 168-171 Protein denotes CD4
T731 181-190 Gene_expression denotes producing
T732 181-190 Gene_expression denotes producing
T733 191-205 Protein denotes interleukin-10
T734 207-212 Protein denotes IL-10
T735 218-230 Protein denotes interferon-γ
T736 232-237 Protein denotes IFN-γ
T737 327-332 Protein denotes IL-10
T738 333-342 Gene_expression denotes producing
T739 411-416 Protein denotes IL-10
T740 417-426 Gene_expression denotes producing
T741 493-497 Protein denotes ERK1
T742 502-506 Protein denotes ERK2
T743 519-534 Phosphorylation denotes phosphorylation
T744 519-534 Phosphorylation denotes phosphorylation
T745 540-545 Protein denotes IL-12
T746 546-553 Positive_regulation denotes induced
T747 554-559 Protein denotes STAT4
T748 581-591 Positive_regulation denotes activation
T749 624-632 Positive_regulation denotes enhanced
T750 633-638 Protein denotes IL-10
T751 639-649 Gene_expression denotes production
T752 678-683 Protein denotes IL-12
T753 724-732 Positive_regulation denotes required
T754 772-777 Protein denotes IL-10
T755 778-787 Gene_expression denotes producing
T756 901-911 Positive_regulation denotes activation
T757 901-911 Positive_regulation denotes activation
T758 915-919 Protein denotes ERK1
T759 924-928 Protein denotes ERK2
T760 942-953 Positive_regulation denotes requirement
T761 942-953 Positive_regulation denotes requirement
T762 958-968 Gene_expression denotes production
T763 972-977 Protein denotes IL-10
T764 1002-1007 Protein denotes IL-10
T765 1008-1018 Gene_expression denotes expression
T766 1040-1045 Protein denotes c-maf
T767 1046-1056 Gene_expression denotes expression
T768 1221-1226 Protein denotes IL-10
T769 1227-1237 Gene_expression denotes production
T2451 1256-1267 Protein denotes erleukin-10
T2452 1269-1274 Protein denotes IL-10
T2453 1410-1415 Protein denotes IL-10
T2454 1687-1692 Protein denotes IL-10
T2455 1696-1705 Gene_expression denotes expressed
T2456 2244-2247 Protein denotes CD4
T2457 2253-2256 Protein denotes CD8
T2458 2282-2285 Protein denotes CD4
T2459 2300-2307 Gene_expression denotes produce
T2460 2300-2307 Gene_expression denotes produce
T2461 2313-2325 Protein denotes interferon-γ
T2462 2327-2332 Protein denotes IFN-γ
T2463 2338-2343 Protein denotes IL-10
T2464 2423-2428 Protein denotes IL-12
T2465 2569-2580 Gene_expression denotes coproducing
T2466 2569-2580 Gene_expression denotes coproducing
T2467 2581-2586 Protein denotes IFN-γ
T2468 2591-2596 Protein denotes IL-10
T2469 2720-2725 Protein denotes IL-10
T2470 2726-2736 Gene_expression denotes production
T2471 3058-3063 Protein denotes IL-10
T2472 3068-3073 Protein denotes IFN-γ
T2473 3074-3082 Gene_expression denotes produced
T2474 3074-3082 Gene_expression denotes produced
T2475 3491-3548 Protein denotes signal transducer and activator of transcription (STAT)1
T2476 3548-3558 Positive_regulation denotes activation
T2477 3560-3567 Positive_regulation denotes induced
T2478 3560-3567 Positive_regulation denotes induced
T2479 3571-3581 Protein denotes type I IFN
T2480 3585-3590 Protein denotes IFN-γ
T2481 3617-3625 Protein denotes T-box 21
T2482 3627-3632 Protein denotes T-bet
T2483 3639-3644 Protein denotes IL-12
T2484 3653-3658 Protein denotes STAT4
T2485 3692-3697 Protein denotes IL-18
T2486 3698-3705 Positive_regulation denotes induced
T2487 3706-3710 Protein denotes IRAK
T2488 3746-3751 Positive_regulation denotes drive
T2489 3761-3768 Gene_expression denotes amounts
T2490 3772-3777 Protein denotes IFN-γ
T2491 3880-3890 Gene_expression denotes expression
T2492 3880-3890 Gene_expression denotes expression
T2493 3880-3890 Gene_expression denotes expression
T2494 3894-3898 Protein denotes IL-4
T2495 3900-3904 Protein denotes IL-5
T2496 3910-3915 Protein denotes IL-13
T2497 3917-3925 Positive_regulation denotes requires
T2498 3917-3925 Positive_regulation denotes requires
T2499 3917-3925 Positive_regulation denotes requires
T2500 3917-3925 Positive_regulation denotes requires
T2501 3917-3925 Positive_regulation denotes requires
T2502 3917-3925 Positive_regulation denotes requires
T2503 3917-3925 Positive_regulation denotes requires
T2504 3917-3925 Positive_regulation denotes requires
T2505 3917-3925 Positive_regulation denotes requires
T2506 3926-3930 Protein denotes IL-4
T2507 3932-3937 Protein denotes STAT6
T2508 3968-3997 Protein denotes GATA binding protein (GATA)-3
T2509 4066-4070 Protein denotes IL-6
T2510 4072-4077 Protein denotes TGF-β
T2511 4087-4092 Protein denotes STAT3
T2512 4093-4102 Positive_regulation denotes dependent
T2513 4103-4113 Gene_expression denotes expression
T2514 4142-4147 Protein denotes RORγt
T2515 4506-4512 Positive_regulation denotes result
T2516 4526-4535 Gene_expression denotes producing
T2517 4536-4541 Protein denotes IFN-γ
T2518 4549-4554 Protein denotes IL-12
T2519 4555-4566 Regulation denotes independent true
T2520 4615-4619 Protein denotes ERK1
T2521 4624-4628 Protein denotes ERK2
T2522 4629-4639 Positive_regulation denotes activation
T2523 4629-4639 Positive_regulation denotes activation
T2524 4641-4646 Positive_regulation denotes favor
T2525 4641-4646 Positive_regulation denotes favor
T2526 4665-4669 Protein denotes IL-4
T2527 4670-4679 Localization denotes secretion
T2528 5004-5009 Protein denotes IL-10
T2529 5010-5018 Gene_expression denotes produced
T2530 5050-5077 Regulation denotes act as a feedback regulator true
T2531 5188-5193 Protein denotes IL-10
T2532 5194-5204 Gene_expression denotes production
T2533 5243-5250 Positive_regulation denotes induced
T2534 5352-5357 Protein denotes IL-10
T2535 5358-5367 Gene_expression denotes producing
T2536 5389-5392 Protein denotes CD4
T2537 5411-5416 Protein denotes IL-12
T2538 5425-5430 Protein denotes STAT4
T2539 5499-5503 Protein denotes ERK1
T2540 5508-5512 Protein denotes ERK2
T2541 5513-5528 Phosphorylation denotes phosphorylation
T2542 5513-5528 Phosphorylation denotes phosphorylation
T2543 5558-5568 Positive_regulation denotes activation
T2544 5558-5568 Positive_regulation denotes activation
T2545 5572-5576 Protein denotes ERK1
T2546 5581-5585 Protein denotes ERK2
T2547 5591-5602 Positive_regulation denotes requirement
T2548 5591-5602 Positive_regulation denotes requirement
T2549 5607-5617 Gene_expression denotes production
T2550 5621-5626 Protein denotes IL-10
T2551 5708-5713 Protein denotes IL-10
T2552 5714-5723 Positive_regulation denotes induction
T4448 5900-5905 Protein denotes IL-12
T4449 5968-5977 Gene_expression denotes Producing
T4450 5978-5983 Protein denotes IL-10
T4451 6026-6037 Gene_expression denotes coproducing
T4452 6026-6037 Gene_expression denotes coproducing
T4453 6038-6043 Protein denotes IFN-γ
T4454 6048-6053 Protein denotes IL-10
T4455 6105-6108 Protein denotes CD4
T4456 6168-6177 Protein denotes ovalbumin
T4457 6195-6198 Protein denotes OVA
T4458 6252-6256 Positive_regulation denotes rise
T4459 6252-6256 Positive_regulation denotes rise
T4460 6270-6280 Gene_expression denotes expressing true
T4461 6270-6280 Gene_expression denotes expressing
T4462 6281-6286 Protein denotes IFN-γ
T4463 6360-6365 Protein denotes IL-10
T4464 6501-6510 Gene_expression denotes expressed
T4465 6501-6510 Gene_expression denotes expressed
T4466 6516-6520 Protein denotes IL-4
T4467 6525-6530 Protein denotes IL-10
T4468 6581-6584 Protein denotes CD4
T4469 6641-6644 Protein denotes CD3
T4470 6654-6658 Protein denotes CD28
T4471 6689-6694 Protein denotes IL-12
T4472 6695-6703 Positive_regulation denotes resulted
T4473 6695-6703 Positive_regulation denotes resulted
T4474 6707-6712 Protein denotes IFN-γ
T4475 6713-6722 Gene_expression denotes producing
T4476 6756-6766 Gene_expression denotes coproduced
T4477 6767-6772 Protein denotes IL-10
T4478 6817-6821 Protein denotes IL-4
T4479 6863-6867 Negative_regulation denotes lack
T4480 6871-6876 Protein denotes IL-10
T4481 6877-6885 Gene_expression denotes produced
T4482 6899-6907 Positive_regulation denotes resulted true
T4483 6913-6923 Negative_regulation denotes inhibition
T4484 6927-6932 Protein denotes IL-10
T4485 6933-6943 Gene_expression denotes production
T4486 6999-7004 Protein denotes IL-12
T4487 7024-7027 Protein denotes CD4
T4488 7105-7110 Protein denotes IL-12
T4489 7137-7142 Protein denotes IL-12
T4490 7186-7193 Positive_regulation denotes induced
T4491 7186-7193 Positive_regulation denotes induced
T4492 7194-7199 Protein denotes IFN-γ
T4493 7200-7210 Gene_expression denotes expression
T4494 7234-7239 Protein denotes IL-10
T4495 7240-7250 Gene_expression denotes expression
T4496 7268-7273 Protein denotes IL-12
T4497 7303-7309 Positive_regulation denotes induce true true
T4498 7322-7327 Protein denotes IL-10
T4499 7328-7338 Gene_expression denotes production
T4500 7440-7445 Protein denotes IL-12
T4501 7478-7483 Protein denotes IL-10
T4502 7484-7493 Gene_expression denotes producing
T4503 7516-7524 Gene_expression denotes produced
T4504 7525-7529 Positive_regulation denotes more
T4505 7530-7535 Protein denotes IL-10
T4506 7619-7628 Gene_expression denotes producing
T4507 7629-7634 Protein denotes IL-10
T4508 7635-7643 Positive_regulation denotes required
T4509 7649-7654 Protein denotes IL-12
T4510 7710-7717 Gene_expression denotes produce
T4511 7710-7717 Gene_expression denotes produce
T4512 7735-7740 Protein denotes IL-10
T4513 7745-7750 Protein denotes IFN-γ
T4514 7755-7759 Negative_regulation denotes lost
T4515 7778-7785 Gene_expression denotes produce
T4516 7786-7790 Protein denotes IL-2
T4517 7828-7833 Protein denotes IL-12
T4518 7863-7866 Protein denotes CD4
T4519 7950-7955 Protein denotes IL-10
T4520 7956-7966 Gene_expression denotes production
T4521 7992-7997 Protein denotes IL-10
T4522 7998-8007 Gene_expression denotes producing
T4523 8044-8051 Negative_regulation denotes limited
T4524 8052-8056 Protein denotes IL-2
T4525 8064-8067 Protein denotes CD4
T4526 8090-8121 Protein denotes recombination-activating gene 1
T4527 8123-8127 Protein denotes Rag1
T4528 8129-8138 Negative_regulation denotes deficient
T4529 8203-8208 Protein denotes IL-12
T4530 8215-8223 Positive_regulation denotes resulted
T4531 8227-8232 Protein denotes IL-10
T4532 8233-8243 Gene_expression denotes expression
T4533 8295-8304 Positive_regulation denotes dependent true
T4534 8414-8419 Protein denotes TGF-β
T4535 8424-8430 Positive_regulation denotes induce true
T4536 8431-8436 Protein denotes IL-10
T4537 8440-8443 Protein denotes CD4
T4538 8593-8607 Negative_regulation denotes neutralization
T4539 8611-8616 Protein denotes TGF-β
T4540 8624-8633 Positive_regulation denotes increased
T4541 8634-8639 Protein denotes IL-10
T4542 8640-8650 Gene_expression denotes production
T4543 8712-8717 Protein denotes IL-10
T4544 8718-8727 Gene_expression denotes producing
T4545 8743-8751 Positive_regulation denotes depended true
T4546 8743-8751 Positive_regulation denotes depended
T4547 8743-8751 Positive_regulation denotes depended true
T4548 8771-8776 Protein denotes IL-12
T4549 8850-8854 Protein denotes IL-2
T4550 8858-8863 Protein denotes TGF-β
T6671 8907-8912 Protein denotes IL-10
T6672 8913-8923 Gene_expression denotes Production
T6673 8940-8949 Positive_regulation denotes Dependent true
T6674 8953-8958 Protein denotes STAT4
T6675 8970-8975 Protein denotes STAT6
T6676 8977-8982 Protein denotes IFN-γ
T6677 8987-8991 Protein denotes IL-4
T6678 9080-9089 Gene_expression denotes producing
T6679 9090-9095 Protein denotes IL-10
T6680 9117-9121 Regulation denotes role true
T6681 9125-9130 Protein denotes STAT4
T6682 9162-9171 Positive_regulation denotes activated
T6683 9175-9180 Protein denotes IL-12
T6684 9210-9213 Protein denotes CD4
T6685 9231-9240 Negative_regulation denotes deficient
T6686 9244-9249 Protein denotes STAT4
T6687 9305-9310 Protein denotes IL-12
T6688 9315-9318 Protein denotes OVA
T6689 9327-9332 Protein denotes IL-10
T6690 9333-9342 Gene_expression denotes producing
T6691 9417-9422 Protein denotes IL-12
T6692 9475-9482 Negative_regulation denotes absence
T6693 9486-9491 Protein denotes STAT4
T6694 9517-9527 Gene_expression denotes expressing
T6695 9528-9533 Protein denotes IFN-γ
T6696 9551-9561 Negative_regulation denotes diminished
T6697 9593-9601 Positive_regulation denotes increase
T6698 9593-9601 Positive_regulation denotes increase
T6699 9629-9639 Gene_expression denotes expressing true
T6700 9629-9639 Gene_expression denotes expressing
T6701 9640-9644 Protein denotes IL-4
T6702 9654-9659 Protein denotes IL-10
T6703 9689-9694 Protein denotes STAT4
T6704 9695-9706 Positive_regulation denotes contributes true
T6705 9710-9715 Protein denotes IL-10
T6706 9716-9726 Gene_expression denotes expression
T6707 9749-9754 Protein denotes IL-10
T6708 9755-9765 Gene_expression denotes expression
T6709 9788-9792 Protein denotes IL-4
T6710 9872-9877 Protein denotes IL-10
T6711 9878-9887 Gene_expression denotes producing
T6712 9932-9936 Protein denotes IL-4
T6713 9950-9955 Protein denotes STAT6
T6714 9956-9966 Positive_regulation denotes activation
T6715 10021-10028 Negative_regulation denotes absence
T6716 10032-10037 Protein denotes STAT6
T6717 10076-10081 Protein denotes IL-10
T6718 10082-10091 Gene_expression denotes producing
T6719 10102-10120 Positive_regulation denotes in the presence of
T6720 10102-10120 Positive_regulation denotes in the presence of
T6721 10121-10126 Protein denotes IL-12
T6722 10131-10134 Protein denotes OVA
T6723 10180-10185 Protein denotes STAT6
T6724 10186-10195 Negative_regulation denotes deficient
T6725 10225-10233 Gene_expression denotes produced
T6726 10225-10233 Gene_expression denotes produced
T6727 10239-10244 Protein denotes IL-10
T6728 10249-10254 Protein denotes IFN-γ
T6729 10363-10367 Negative_regulation denotes lack
T6730 10371-10376 Protein denotes STAT6
T6731 10377-10386 Negative_regulation denotes abrogated
T6732 10377-10386 Negative_regulation denotes abrogated
T6733 10392-10396 Protein denotes IL-4
T6734 10401-10406 Protein denotes IL-10
T6735 10407-10417 Gene_expression denotes production
T6736 10407-10417 Gene_expression denotes production
T6737 10444-10448 Protein denotes IL-4
T6738 10522-10527 Protein denotes STAT4
T6739 10539-10544 Protein denotes IL-10
T6740 10549-10553 Protein denotes IL-4
T6741 10554-10564 Gene_expression denotes production
T6742 10554-10564 Gene_expression denotes production
T6743 10594-10603 Positive_regulation denotes increased
T6744 10594-10603 Positive_regulation denotes increased
T6745 10686-10691 Protein denotes IL-10
T6746 10692-10702 Gene_expression denotes expression
T6747 10716-10724 Positive_regulation denotes depended true
T6748 10728-10733 Protein denotes STAT6
T6749 10746-10751 Protein denotes STAT4
T6750 10811-10820 Negative_regulation denotes inability
T6751 10824-10829 Protein denotes STAT4
T6752 10830-10839 Negative_regulation denotes deficient
T6753 10851-10858 Gene_expression denotes produce
T6754 10859-10864 Protein denotes IL-10
T6755 10874-10877 Positive_regulation denotes due true
T6756 10885-10892 Negative_regulation denotes absence
T6757 10896-10901 Protein denotes IFN-γ
T6758 10981-10986 Protein denotes IFN-γ
T6759 10987-10996 Negative_regulation denotes deficient
T6760 11003-11006 Protein denotes CD4
T6761 11035-11040 Protein denotes IL-12
T6762 11065-11068 Protein denotes OVA
T6763 11074-11083 Localization denotes secretion
T6764 11087-11092 Protein denotes IL-10
T6765 11096-11103 Positive_regulation denotes induced
T6766 11130-11135 Protein denotes IL-12
T6767 11144-11152 Regulation denotes affected true
T6768 11159-11166 Negative_regulation denotes absence
T6769 11170-11175 Protein denotes IFN-γ
T6770 11206-11216 Gene_expression denotes expression
T6771 11220-11225 Protein denotes IL-10
T6772 11242-11253 Regulation denotes independent true
T6773 11257-11262 Protein denotes IFN-γ
T6774 11271-11278 Negative_regulation denotes absence
T6775 11282-11287 Protein denotes IFN-γ
T6776 11304-11312 Positive_regulation denotes increase
T6777 11320-11328 Localization denotes secreted
T6778 11329-11333 Protein denotes IL-4
T6779 11397-11401 Regulation denotes role true
T6780 11405-11409 Protein denotes IL-4
T6781 11442-11451 Gene_expression denotes producing
T6782 11452-11457 Protein denotes IL-10
T6783 11490-11494 Protein denotes IL-4
T6784 11495-11504 Negative_regulation denotes deficient
T6785 11511-11514 Protein denotes CD4
T6786 11529-11534 Protein denotes IL-12
T6787 11587-11594 Negative_regulation denotes absence
T6788 11598-11603 Protein denotes STAT6
T6789 11617-11621 Protein denotes IL-4
T6790 11622-11632 Negative_regulation denotes deficiency
T6791 11679-11688 Gene_expression denotes producing
T6792 11689-11694 Protein denotes IL-10
T6793 11753-11762 Gene_expression denotes producing
T6794 11763-11768 Protein denotes IL-10
T6795 11812-11817 Protein denotes IL-10
T6796 11818-11828 Gene_expression denotes production
T6797 11945-11950 Protein denotes STAT4
T6798 11971-11980 Positive_regulation denotes induction
T6799 11971-11980 Positive_regulation denotes induction
T6800 11984-11989 Protein denotes IL-10
T6801 11990-12000 Gene_expression denotes production
T6802 12018-12023 Protein denotes STAT6
T7659 12063-12068 Protein denotes STAT4
T7660 12112-12117 Protein denotes IL-10
T7661 12118-12127 Gene_expression denotes Producing
T7662 12164-12174 Regulation denotes regulating
T7663 12175-12180 Protein denotes IL-10
T7664 12181-12191 Gene_expression denotes production
T7665 12323-12326 Protein denotes OVA
T7666 12487-12490 Protein denotes OVA
T7667 12536-12543 Positive_regulation denotes induced
T7668 12536-12543 Positive_regulation denotes induced
T7669 12544-12549 Protein denotes IL-10
T7670 12554-12559 Protein denotes IFN-γ
T7671 12560-12570 Gene_expression denotes production
T7672 12560-12570 Gene_expression denotes production
T7673 12590-12595 Protein denotes IL-10
T7674 12596-12606 Gene_expression denotes production
T7675 12611-12619 Positive_regulation denotes enhanced
T7676 12696-12699 Protein denotes OVA
T7677 12756-12761 Protein denotes STAT4
T7678 12766-12771 Protein denotes STAT6
T7679 12812-12817 Protein denotes IL-10
T7680 12818-12827 Gene_expression denotes producing
T7681 12854-12859 Protein denotes STAT4
T7682 12864-12869 Protein denotes STAT6
T7683 12870-12879 Negative_regulation denotes deficient
T7684 12870-12879 Negative_regulation denotes deficient
T7685 12946-12949 Protein denotes OVA
T7686 12986-12996 Gene_expression denotes expression
T7687 12986-12996 Gene_expression denotes expression
T7688 13005-13010 Protein denotes IL-10
T7689 13015-13020 Protein denotes IFN-γ
T7690 13034-13041 Negative_regulation denotes reduced
T7691 13034-13041 Negative_regulation denotes reduced
T7692 13050-13070 Negative_regulation denotes completely abrogated true
T7693 13050-13070 Negative_regulation denotes completely abrogated true
T7694 13089-13094 Protein denotes STAT4
T7695 13237-13242 Protein denotes STAT6
T7696 13250-13256 Regulation denotes effect true
T7697 13260-13265 Protein denotes IL-10
T7698 13266-13276 Gene_expression denotes production
T7699 13362-13367 Protein denotes STAT6
T7700 13368-13377 Negative_regulation denotes deficient
T8961 13408-13413 Protein denotes IL-10
T8962 13414-13424 Gene_expression denotes Production
T8963 13428-13438 Positive_regulation denotes Maintained
T8964 13471-13476 Protein denotes IL-12
T8965 13566-13571 Protein denotes IL-12
T8966 13580-13585 Protein denotes STAT4
T8967 13603-13612 Positive_regulation denotes induction
T8968 13616-13621 Protein denotes IL-10
T8969 13646-13649 Protein denotes CD4
T8970 13757-13762 Protein denotes IL-12
T8971 13813-13818 Protein denotes IL-12
T8972 13833-13839 Positive_regulation denotes induce
T8973 13848-13853 Protein denotes IL-10
T8974 13854-13864 Gene_expression denotes production
T8975 13949-13954 Protein denotes IL-10
T8976 13955-13964 Gene_expression denotes producing
T8977 14051-14056 Protein denotes IL-12
T8978 14057-14065 Positive_regulation denotes resulted
T8979 14073-14083 Gene_expression denotes production
T8980 14087-14092 Protein denotes IL-10
T8981 14171-14175 Positive_regulation denotes need
T8982 14180-14185 Protein denotes IL-12
T8983 14190-14195 Protein denotes IL-10
T8984 14196-14205 Positive_regulation denotes induction
T8985 14236-14241 Protein denotes IL-10
T8986 14242-14251 Positive_regulation denotes induction
T8987 14279-14288 Negative_regulation denotes abrogated
T8988 14294-14302 Protein denotes IL-12p40
T8989 14303-14312 Negative_regulation denotes deficient
T8990 14354-14359 Protein denotes IL-12
T8991 14363-14372 Positive_regulation denotes essential
T8992 14433-14443 Gene_expression denotes production
T8993 14447-14452 Protein denotes IL-10
T8994 14518-14523 Protein denotes IL-10
T8995 14524-14533 Gene_expression denotes producing
T8996 14563-14566 Protein denotes CD4
T8997 14627-14632 Protein denotes IL-12
T8998 14772-14777 Protein denotes IL-12
T8999 14801-14808 Positive_regulation denotes induced
T9000 14830-14837 Gene_expression denotes produce
T9001 14838-14843 Protein denotes IL-10
T9002 14883-14888 Protein denotes IL-12
T9003 14889-14893 Negative_regulation denotes lost
T9004 14911-14918 Gene_expression denotes express
T9005 14919-14924 Protein denotes IL-10
T9006 14959-14962 Protein denotes OVA
T9007 14979-14990 Negative_regulation denotes compensated
T9008 15015-15023 Positive_regulation denotes addition
T9009 15027-15032 Protein denotes IL-12
T9010 15111-15116 Protein denotes IL-12
T9011 15125-15134 Positive_regulation denotes cooperate true
T9012 15143-15152 Gene_expression denotes induction
T9013 15156-15161 Protein denotes IL-10
T9014 15180-15183 Protein denotes CD4
T9015 15237-15242 Protein denotes IL-12
T9016 15284-15292 Gene_expression denotes produced
T9017 15284-15292 Gene_expression denotes produced true
T9018 15309-15314 Protein denotes IFN-γ
T9019 15326-15331 Protein denotes IL-10
T9020 15351-15358 Positive_regulation denotes induced
T9021 15362-15369 Gene_expression denotes produce
T9022 15370-15375 Protein denotes IL-10
T9023 15408-15413 Protein denotes IL-12
T9024 15492-15497 Protein denotes IL-12
T9025 15530-15539 Positive_regulation denotes induction
T9026 15543-15548 Protein denotes IL-10
T9027 15549-15559 Gene_expression denotes production
T10687 15575-15580 Protein denotes IL-10
T10688 15581-15591 Gene_expression denotes Production
T10689 15605-15613 Positive_regulation denotes Requires
T10690 15605-15613 Positive_regulation denotes Requires
T10691 15605-15613 Positive_regulation denotes Requires
T10692 15605-15613 Positive_regulation denotes Requires
T10693 15614-15618 Protein denotes ERK1
T10694 15623-15627 Protein denotes ERK2
T10695 15628-15638 Positive_regulation denotes Activation
T10696 15628-15638 Positive_regulation denotes Activation
T10697 15664-15675 Positive_regulation denotes maintenance
T10698 15679-15684 Protein denotes IL-10
T10699 15685-15694 Gene_expression denotes induction
T10700 15708-15716 Positive_regulation denotes required
T10701 15806-15814 Positive_regulation denotes addition
T10702 15818-15823 Protein denotes IL-12
T10703 15878-15885 Positive_regulation denotes induced
T10704 15878-15885 Positive_regulation denotes induced
T10705 15895-15899 Protein denotes ERK1
T10706 15904-15908 Protein denotes ERK2
T10707 15909-15919 Positive_regulation denotes activation
T10708 15909-15919 Positive_regulation denotes activation
T10709 15930-15937 Positive_regulation denotes induced
T10710 15930-15937 Positive_regulation denotes induced
T10711 15977-15980 Protein denotes CD4
T10712 16071-16074 Protein denotes CD4
T10713 16192-16196 Protein denotes ERK1
T10714 16201-16205 Protein denotes ERK2
T10715 16206-16216 Positive_regulation denotes activation
T10716 16206-16216 Positive_regulation denotes activation
T10717 16341-16349 Positive_regulation denotes enhanced
T10718 16341-16349 Positive_regulation denotes enhanced
T10719 16354-16363 Positive_regulation denotes prolonged
T10720 16354-16363 Positive_regulation denotes prolonged
T10721 16364-16368 Protein denotes ERK1
T10722 16373-16377 Protein denotes ERK2
T10723 16378-16388 Positive_regulation denotes activation
T10724 16378-16388 Positive_regulation denotes activation
T10725 16408-16413 Protein denotes IL-12
T10726 16532-16536 Protein denotes ERK1
T10727 16541-16545 Protein denotes ERK2
T10728 16546-16556 Positive_regulation denotes activation
T10729 16546-16556 Positive_regulation denotes activation
T10730 16561-16569 Positive_regulation denotes required true
T10731 16561-16569 Positive_regulation denotes required true
T10732 16578-16587 Positive_regulation denotes induction
T10733 16591-16596 Protein denotes IL-10
T10734 16866-16869 Protein denotes CD3
T10735 16895-16900 Protein denotes IL-12
T10736 16972-16977 Protein denotes IL-12
T10737 17013-17022 Gene_expression denotes producing
T10738 17013-17022 Gene_expression denotes producing
T10739 17028-17033 Protein denotes IL-10
T10740 17038-17043 Protein denotes IFN-γ
T10741 17115-17124 Negative_regulation denotes abrogated
T10742 17129-17139 Gene_expression denotes production
T10743 17143-17148 Protein denotes IL-10
T10744 17170-17173 Protein denotes CD3
T10745 17201-17209 Negative_regulation denotes inhibits
T10746 17201-17209 Negative_regulation denotes inhibits
T10747 17201-17209 Negative_regulation denotes inhibits
T10748 17201-17209 Negative_regulation denotes inhibits
T10749 17201-17209 Negative_regulation denotes inhibits
T10750 17214-17218 Protein denotes MEK5
T10751 17219-17228 Positive_regulation denotes catalyzed
T10752 17229-17239 Positive_regulation denotes activation
T10753 17243-17247 Protein denotes ERK5
T10754 17264-17268 Protein denotes MEK1
T10755 17274-17278 Protein denotes MEK2
T10756 17279-17288 Positive_regulation denotes catalyzed
T10757 17279-17288 Positive_regulation denotes catalyzed
T10758 17279-17288 Positive_regulation denotes catalyzed
T10759 17279-17288 Positive_regulation denotes catalyzed
T10760 17289-17299 Positive_regulation denotes activation
T10761 17289-17299 Positive_regulation denotes activation
T10762 17303-17307 Protein denotes ERK1
T10763 17312-17316 Protein denotes ERK2
T10764 17412-17416 Protein denotes MEK1
T10765 17421-17425 Protein denotes MEK2
T10766 17426-17435 Negative_regulation denotes inhibitor
T10767 17426-17435 Negative_regulation denotes inhibitor
T10768 17475-17483 Negative_regulation denotes inhibits true
T10769 17475-17483 Negative_regulation denotes inhibits
T10770 17475-17483 Negative_regulation denotes inhibits
T10771 17484-17488 Protein denotes MEK1
T10772 17493-17497 Protein denotes MEK2
T10773 17506-17510 Protein denotes MEK5
T10774 17577-17587 Negative_regulation denotes inhibition
T10775 17591-17596 Protein denotes IL-10
T10776 17597-17607 Gene_expression denotes production
T10777 17746-17754 Protein denotes p38 MAPK
T10778 17755-17764 Negative_regulation denotes inhibitor
T10779 17783-17788 Protein denotes GSK3β
T10780 17789-17798 Negative_regulation denotes inhibitor
T10781 17832-17838 Regulation denotes effect true
T10782 17832-17838 Regulation denotes effect true
T10783 17842-17847 Protein denotes IL-10
T10784 17848-17858 Gene_expression denotes production
T10785 17915-17920 Protein denotes IL-10
T10786 17921-17931 Gene_expression denotes production
T10787 17945-17959 Positive_regulation denotes in response to
T10788 17982-17987 Protein denotes IL-12
T10789 17988-17996 Positive_regulation denotes requires true true
T10790 17988-17996 Positive_regulation denotes requires true true
T10791 17997-18001 Protein denotes ERK1
T10792 18006-18010 Protein denotes ERK2
T10793 18034-18044 Positive_regulation denotes activation
T10794 18034-18044 Positive_regulation denotes activation
T10795 18052-18055 Protein denotes p38
T10796 18063-18068 Protein denotes GSK3β
T11552 18080-18085 Protein denotes IL-10
T11553 18086-18096 Gene_expression denotes Production
T11554 18124-18132 Positive_regulation denotes Requires
T11555 18124-18132 Positive_regulation denotes Requires
T11556 18133-18137 Protein denotes ERK1
T11557 18142-18146 Protein denotes ERK2
T11558 18147-18157 Positive_regulation denotes Activation
T11559 18147-18157 Positive_regulation denotes Activation
T11560 18177-18182 Protein denotes IL-10
T11561 18183-18193 Gene_expression denotes production
T11562 18225-18234 Positive_regulation denotes dependent true
T11563 18225-18234 Positive_regulation denotes dependent true
T11564 18238-18242 Protein denotes ERK1
T11565 18247-18251 Protein denotes ERK2
T11566 18252-18262 Positive_regulation denotes activation
T11567 18252-18262 Positive_regulation denotes activation
T11568 18304-18307 Protein denotes CD3
T11569 18317-18321 Protein denotes CD28
T11570 18451-18454 Protein denotes MEK
T11571 18455-18464 Negative_regulation denotes inhibitor
T11572 18492-18496 Protein denotes ERK1
T11573 18501-18505 Protein denotes ERK2
T11574 18506-18516 Positive_regulation denotes activation
T11575 18506-18516 Positive_regulation denotes activation
T11576 18537-18545 Positive_regulation denotes required
T11577 18537-18545 Positive_regulation denotes required
T11578 18550-18559 Gene_expression denotes induction
T11579 18563-18568 Protein denotes IL-10
T11580 18606-18611 Protein denotes IL-10
T11581 18612-18622 Gene_expression denotes production
T11582 18663-18672 Negative_regulation denotes inhibited
T11583 18696-18699 Protein denotes MEK
T11584 18700-18709 Negative_regulation denotes inhibitor
T11585 18762-18772 Negative_regulation denotes inhibitors
T11586 18762-18772 Negative_regulation denotes inhibitors
T11587 18776-18784 Protein denotes p38 MAPK
T11588 18791-18797 Protein denotes GSK-3β
T11589 18798-18808 Positive_regulation denotes activation
T11590 18798-18808 Positive_regulation denotes activation
T11591 18817-18823 Regulation denotes affect true
T11592 18817-18823 Regulation denotes affect true
T11593 18828-18838 Gene_expression denotes expression
T11594 18842-18847 Protein denotes IL-10
T11595 18897-18901 Protein denotes ERK1
T11596 18906-18910 Protein denotes ERK2
T11597 18951-18962 Positive_regulation denotes requirement
T11598 18971-18980 Positive_regulation denotes induction
T11599 18984-18989 Protein denotes IL-10
T11600 18990-19000 Gene_expression denotes production
T13326 19031-19036 Protein denotes c-maf
T13327 19037-19047 Gene_expression denotes Expression
T13328 19064-19069 Protein denotes IL-10
T13329 19070-19080 Gene_expression denotes Production
T13330 19167-19177 Regulation denotes regulating
T13331 19178-19183 Protein denotes IL-10
T13332 19184-19194 Gene_expression denotes production
T13333 19222-19225 Protein denotes CD4
T13334 19260-19263 Protein denotes OVA
T13335 19295-19300 Protein denotes IL-12
T13336 19409-19417 Positive_regulation denotes resulted
T13337 19421-19434 Transcription denotes transcription
T13338 19438-19441 Protein denotes Il4
T13339 19455-19464 Negative_regulation denotes abrogated
T13340 19496-19501 Protein denotes IL-12
T13341 19531-19544 Transcription denotes transcription
T13342 19548-19552 Protein denotes Ifnγ
T13343 19557-19564 Positive_regulation denotes induced
T13344 19568-19573 Protein denotes IL-12
T13345 19632-19643 Positive_regulation denotes this effect
T13346 19647-19652 Protein denotes IL-12
T13347 19666-19677 Positive_regulation denotes upregulated
T13348 19740-19744 Protein denotes Il10
T13349 19745-19758 Transcription denotes transcription
T13350 19809-19812 Protein denotes Il4
T13351 19813-19823 Gene_expression denotes expression
T13352 19858-19867 Negative_regulation denotes abrogated
T13353 19858-19867 Negative_regulation denotes abrogated
T13354 19905-19908 Protein denotes Il4
T13355 19909-19919 Gene_expression denotes expression
T13356 19958-19963 Protein denotes IL-12
T13357 19975-19981 Regulation denotes effect true
T13358 19985-19993 Positive_regulation denotes increase
T13359 19994-19999 Protein denotes IL-10
T13360 20000-20015 Transcription denotes mRNA expression
T13361 20083-20088 Protein denotes IL-12
T13362 20089-20096 Positive_regulation denotes induced
T13363 20089-20096 Positive_regulation denotes induced
T13364 20114-20118 Protein denotes Il10
T13365 20119-20132 Transcription denotes transcription
T13366 20144-20148 Protein denotes Ifnγ
T13367 20149-20159 Gene_expression denotes expression
T13368 20254-20257 Protein denotes CD4
T13369 20323-20330 Transcription denotes express true
T13370 20347-20353 Protein denotes Tbx-21
T13371 20355-20360 Protein denotes T-bet
T13372 20401-20406 Protein denotes IL-12
T13373 20449-20455 Protein denotes GATA-3
T13374 20456-20471 Transcription denotes mRNA expression
T13375 20598-20611 Negative_regulation denotes downregulated
T13376 20661-20666 Protein denotes IL-12
T13377 20730-20733 Positive_regulation denotes led
T13378 20737-20747 Gene_expression denotes expression
T13379 20751-20756 Protein denotes c-maf
T13380 20842-20851 Negative_regulation denotes abrogated
T13381 20911-20916 Protein denotes IL-12
T13382 20917-20926 Positive_regulation denotes sustained
T13383 20936-20946 Transcription denotes expression
T13384 20950-20955 Protein denotes c-Maf
T13385 21017-21022 Protein denotes IL-12
T13386 21023-21034 Positive_regulation denotes maintenance
T13387 21038-21043 Protein denotes c-maf
T13388 21044-21054 Gene_expression denotes expression
T13389 21055-21063 Positive_regulation denotes required
T13390 21064-21069 Protein denotes STAT4
T13391 21070-21080 Positive_regulation denotes activation
T13392 21118-21127 Transcription denotes expressed
T13393 21118-21127 Transcription denotes expressed
T13394 21128-21134 Protein denotes IL-17a
T13395 21146-21151 Protein denotes IL-10
T13396 21170-21175 Protein denotes T-bet
T13397 21180-21186 Protein denotes GATA-3
T13398 21187-21191 Transcription denotes mRNA
T13399 21187-21191 Transcription denotes mRNA
T13400 21197-21209 Negative_regulation denotes undetectable
T13401 21197-21209 Negative_regulation denotes undetectable
T13402 21244-21250 Protein denotes ROR-γt
T13403 21255-21259 Positive_regulation denotes high
T13404 21311-21320 Gene_expression denotes expressed
T13405 21337-21342 Protein denotes c-maf
T13406 21407-21412 Protein denotes c-Maf
T13407 21426-21435 Gene_expression denotes expressed
T13408 21443-21448 Protein denotes IL-10
T13409 21449-21459 Gene_expression denotes expressing
T13410 21633-21637 Protein denotes Il10
T13411 21638-21648 Gene_expression denotes expression
T13412 21650-21655 Protein denotes c-maf
T13413 21656-21666 Gene_expression denotes expression
T13414 21671-21680 Negative_regulation denotes inhibited
T13415 21671-21680 Negative_regulation denotes inhibited
T13416 21671-21680 Negative_regulation denotes inhibited
T13417 21671-21680 Negative_regulation denotes inhibited
T13418 21726-21730 Protein denotes MEK1
T13419 21735-21739 Protein denotes MEK2
T13420 21740-21749 Negative_regulation denotes inhibitor
T13421 21740-21749 Negative_regulation denotes inhibitor
T13422 21770-21775 Protein denotes T-bet
T13423 21780-21785 Protein denotes RORγt
T13424 21786-21796 Gene_expression denotes expression
T13425 21786-21796 Gene_expression denotes expression
T13426 21808-21816 Regulation denotes affected true
T13427 21808-21816 Regulation denotes affected true
T13428 21808-21816 Regulation denotes affected true
T13429 21808-21816 Regulation denotes affected true
T18186 21842-21847 Protein denotes IL-10
T18187 21848-21858 Gene_expression denotes expression
T18188 22039-22044 Protein denotes IL-10
T18189 22045-22055 Gene_expression denotes expression
T18190 22184-22189 Protein denotes IL-10
T18191 22197-22205 Gene_expression denotes produced
T18192 22219-22233 Positive_regulation denotes in response to true
T18193 22347-22354 Gene_expression denotes produce
T18194 22355-22360 Protein denotes IL-10
T18195 22412-22420 Positive_regulation denotes required
T18196 22412-22420 Positive_regulation denotes required
T18197 22412-22420 Positive_regulation denotes required
T18198 22447-22451 Protein denotes ERK1
T18199 22456-22460 Protein denotes ERK2
T18200 22461-22476 Phosphorylation denotes phosphorylation
T18201 22461-22476 Phosphorylation denotes phosphorylation
T18202 22481-22486 Protein denotes IL-12
T18203 22487-22494 Positive_regulation denotes induced
T18204 22495-22501 Protein denotes STAT-4
T18205 22502-22512 Positive_regulation denotes activation
T18206 22516-22523 Gene_expression denotes produce
T18207 22524-22529 Protein denotes IL-10
T18208 22549-22553 Protein denotes ERK1
T18209 22558-22562 Protein denotes ERK2
T18210 22563-22573 Positive_regulation denotes activation
T18211 22563-22573 Positive_regulation denotes activation
T18212 22595-22603 Positive_regulation denotes required
T18213 22595-22603 Positive_regulation denotes required
T18214 22612-22622 Gene_expression denotes production
T18215 22626-22631 Protein denotes IL-10
T18216 22723-22728 Protein denotes IL-10
T18217 22729-22770 Regulation denotes provides a highly regulated feedback loop
T18218 23107-23112 Protein denotes IL-10
T18219 23362-23369 Positive_regulation denotes induced
T18220 23373-23380 Gene_expression denotes express
T18221 23397-23402 Protein denotes IL-10
T18222 23433-23438 Protein denotes IL-10
T18223 23439-23448 Gene_expression denotes producing
T18224 23473-23476 Protein denotes CD4
T18225 23702-23707 Protein denotes IL-10
T18226 23721-23726 Protein denotes Foxp3
T18227 23743-23752 Gene_expression denotes coproduce
T18228 23743-23752 Gene_expression denotes coproduce
T18229 23753-23758 Protein denotes IL-10
T18230 23763-23768 Protein denotes IFN-γ
T18231 23879-23884 Protein denotes Foxp3
T18232 23939-23944 Protein denotes IL-10
T18233 23945-23955 Gene_expression denotes production
T18234 24063-24066 Protein denotes CD4
T18235 24076-24085 Gene_expression denotes producing
T18236 24086-24091 Protein denotes IL-10
T18237 24325-24328 Protein denotes CD4
T18238 24374-24379 Protein denotes IL-12
T18239 24451-24461 Gene_expression denotes expressing
T18240 24451-24461 Gene_expression denotes expressing
T18241 24479-24484 Protein denotes IFN-γ
T18242 24489-24494 Protein denotes IL-10
T18243 24496-24500 Negative_regulation denotes lose
T18244 24507-24511 Protein denotes IL-2
T18245 24512-24522 Gene_expression denotes expression
T18246 24627-24631 Negative_regulation denotes loss
T18247 24635-24639 Protein denotes IL-2
T18248 24658-24668 Gene_expression denotes production
T18249 24672-24677 Protein denotes IL-10
T18250 24893-24898 Protein denotes IL-10
T18251 24972-24975 Protein denotes OVA
T18252 25018-25027 Positive_regulation denotes induction
T18253 25031-25036 Protein denotes IL-10
T18254 25089-25096 Negative_regulation denotes reduced
T18255 25100-25105 Protein denotes STAT4
T18256 25106-25115 Negative_regulation denotes deficient
T18257 25353-25364 Positive_regulation denotes requirement
T18258 25369-25374 Protein denotes IL-12
T18259 25382-25391 Positive_regulation denotes induction
T18260 25395-25400 Protein denotes IL-10
T18261 25534-25543 Gene_expression denotes producing
T18262 25544-25549 Protein denotes IL-10
T18263 25556-25561 Protein denotes IL-12
T18264 25580-25585 Protein denotes IL-10
T18265 25586-25596 Gene_expression denotes production
T18266 25610-25617 Positive_regulation denotes induced
T18267 25643-25648 Protein denotes IL-12
T18268 25653-25664 Regulation denotes independent true
T18269 25668-25673 Protein denotes IFN-γ
T18270 25754-25759 Protein denotes IFN-γ
T18271 25763-25772 Positive_regulation denotes mediating true
T18272 25773-25778 Protein denotes IL-10
T18273 25779-25791 Positive_regulation denotes reactivation
T18274 25906-25909 Protein denotes CD4
T18275 25960-25967 Gene_expression denotes express true
T18276 25968-25973 Protein denotes IL-10
T18277 26005-26012 Positive_regulation denotes induced
T18278 26016-26023 Gene_expression denotes produce
T18279 26024-26029 Protein denotes IL-10
T18280 26117-26122 Protein denotes IL-12
T18281 26141-26150 Positive_regulation denotes dependent
T18282 26158-26167 Positive_regulation denotes induction
T18283 26171-26176 Protein denotes IL-12
T18284 26250-26255 Protein denotes IL-12
T18285 26256-26264 Positive_regulation denotes resulted
T18286 26290-26295 Protein denotes IL-10
T18287 26296-26306 Gene_expression denotes production
T18288 26346-26350 Protein denotes ERK1
T18289 26355-26359 Protein denotes ERK2
T18290 26360-26370 Positive_regulation denotes activation
T18291 26360-26370 Positive_regulation denotes activation
T18292 26376-26385 Positive_regulation denotes increased
T18293 26386-26396 Gene_expression denotes expression
T18294 26400-26405 Protein denotes IFN-γ
T18295 26447-26453 Positive_regulation denotes induce
T18296 26454-26463 Positive_regulation denotes increased
T18297 26464-26469 Protein denotes IL-12
T18298 26470-26480 Gene_expression denotes production
T18299 26555-26565 Positive_regulation denotes upregulate true
T18300 26566-26571 Protein denotes IL-12
T18301 26572-26582 Gene_expression denotes production
T18302 26669-26680 Positive_regulation denotes requirement
T18303 26685-26690 Protein denotes IFN-γ
T18304 26694-26700 Positive_regulation denotes induce
T18305 26701-26706 Protein denotes IL-10
T18306 26725-26737 Positive_regulation denotes upregulation
T18307 26741-26746 Protein denotes IL-12
T18308 26769-26776 Positive_regulation denotes induced
T18309 26777-26782 Protein denotes IL-10
T18310 26810-26815 Protein denotes IL-10
T18311 26838-26847 Regulation denotes regulated
T18312 27053-27058 Protein denotes OX-40
T18313 27086-27105 Negative_regulation denotes negatively regulate
T18314 27106-27111 Protein denotes IL-10
T18315 27112-27122 Gene_expression denotes production
T18316 27177-27181 Protein denotes ICOS
T18317 27214-27220 Positive_regulation denotes induce true
T18318 27221-27226 Protein denotes IL-10
T18319 27318-27322 Protein denotes ICOS
T18320 27338-27347 Regulation denotes regulates
T18321 27348-27352 Protein denotes IL-4
T18322 27353-27363 Gene_expression denotes production
T18323 27445-27449 Protein denotes ERK1
T18324 27454-27458 Protein denotes ERK2
T18325 27459-27469 Positive_regulation denotes activation
T18326 27459-27469 Positive_regulation denotes activation
T18327 27478-27488 Regulation denotes regulation
T18328 27478-27488 Regulation denotes regulation
T18329 27492-27497 Protein denotes IL-10
T18330 27498-27508 Gene_expression denotes production
T18331 27666-27671 Protein denotes IL-10
T18332 27730-27738 Gene_expression denotes produced
T18333 27752-27761 Regulation denotes regulated
T18334 27818-27822 Regulation denotes role
T18335 27818-27822 Regulation denotes role
T18336 27827-27831 Protein denotes ERK1
T18337 27836-27840 Protein denotes ERK2
T18338 27841-27851 Positive_regulation denotes activation
T18339 27841-27851 Positive_regulation denotes activation
T18340 27859-27868 Positive_regulation denotes induction
T18341 27872-27877 Protein denotes IL-10
T18342 27878-27888 Gene_expression denotes production
T18343 28013-28023 Regulation denotes regulation
T18344 28027-28032 Protein denotes IL-10
T18345 28128-28135 Protein denotes histone
T18346 28155-28160 Protein denotes IL-10
T18347 28275-28280 Protein denotes IL-10
T18348 28284-28292 Gene_expression denotes produced
T18349 28329-28339 Gene_expression denotes expression
T18350 28360-28370 Gene_expression denotes expression
T18351 28374-28379 Protein denotes T-bet
T18352 28396-28401 Protein denotes IFN-γ
T18353 28402-28412 Gene_expression denotes production
T18354 28486-28491 Protein denotes IL-12
T18355 28506-28514 Positive_regulation denotes required
T18356 28506-28514 Positive_regulation denotes required
T18357 28519-28524 Protein denotes IL-10
T18358 28529-28534 Protein denotes IFN-γ
T18359 28535-28545 Gene_expression denotes expression
T18360 28535-28545 Gene_expression denotes expression
T18361 28575-28586 Positive_regulation denotes maintenance
T18362 28590-28595 Protein denotes IL-10
T18363 28596-28606 Gene_expression denotes expression
T18364 28610-28621 Positive_regulation denotes conditional
T18365 28610-28621 Positive_regulation denotes conditional
T18366 28625-28630 Protein denotes IL-12
T18367 28634-28638 Protein denotes IL-4
T18368 28650-28655 Protein denotes IL-10
T18369 28677-28683 Protein denotes GATA-3
T18370 28728-28733 Protein denotes IL-10
T18371 28780-28785 Protein denotes IL-10
T18372 28786-28794 Gene_expression denotes produced
T18373 28894-28899 Protein denotes IL-12
T18374 28912-28924 Negative_regulation denotes downregulate
T18375 28925-28931 Protein denotes Gata-3
T18376 28932-28942 Gene_expression denotes expression
T18377 28995-29001 Positive_regulation denotes induce true
T18378 29002-29007 Protein denotes IL-10
T18379 29008-29018 Gene_expression denotes expression
T18380 29053-29063 Gene_expression denotes Expression
T18381 29067-29072 Protein denotes c-maf
T18382 29085-29095 Negative_regulation denotes diminished
T18383 29154-29164 Positive_regulation denotes maintained
T18384 29168-29173 Protein denotes IL-12
T18385 29206-29211 Protein denotes c-maf
T18386 29212-29222 Gene_expression denotes expression
T18387 29236-29241 Protein denotes IL-10
T18388 29242-29251 Gene_expression denotes producing
T18389 29287-29292 Protein denotes IL-10
T18390 29297-29306 Positive_regulation denotes dependent
T18391 29297-29306 Positive_regulation denotes dependent
T18392 29310-29313 Protein denotes ERK
T18393 29314-29324 Positive_regulation denotes activation
T18394 29355-29365 Gene_expression denotes expression
T18395 29389-29394 Protein denotes c-Maf
T18396 29419-29428 Positive_regulation denotes essential
T18397 29454-29459 Protein denotes IL-10
T18398 29460-29470 Gene_expression denotes expression
T18399 29559-29562 Protein denotes CD4
T18400 29664-29671 Positive_regulation denotes induced
T18401 29675-29679 Gene_expression denotes make
T18402 29680-29685 Protein denotes IL-10
T18403 29687-29691 Protein denotes ERK1
T18404 29696-29700 Protein denotes ERK2
T18405 29701-29711 Positive_regulation denotes activation
T18406 29701-29711 Positive_regulation denotes activation
T18407 29715-29723 Positive_regulation denotes required
T18408 29715-29723 Positive_regulation denotes required
T18409 29728-29733 Protein denotes IL-10
T18410 29734-29744 Gene_expression denotes production
T18411 29794-29804 Gene_expression denotes expression
T18412 29808-29813 Protein denotes IL-10
T18413 29865-29870 Protein denotes IL-10
T18414 29871-29881 Gene_expression denotes expression
T18415 29885-29892 Positive_regulation denotes induced
T18416 29902-29911 Positive_regulation denotes amplified
T18417 29916-29925 Regulation denotes regulated
T18418 29955-29960 Protein denotes IL-12
T18419 30129-30137 Regulation denotes regulate
T18420 30142-30152 Gene_expression denotes production
T18421 30156-30161 Protein denotes IL-10
T18422 30350-30360 Regulation denotes regulation
T18423 30364-30369 Protein denotes IL-10
T18424 30370-30380 Gene_expression denotes production
T19021 30650-30653 Protein denotes OVA
T19022 30691-30695 Protein denotes Rag1
T19023 30698-30702 Protein denotes IL-4
T19024 30705-30710 Protein denotes IFN-γ
T19025 30713-30718 Protein denotes STAT4
T19026 30725-30730 Protein denotes STAT6
T19027 30731-30740 Negative_regulation denotes deficient
T19028 30731-30740 Negative_regulation denotes deficient
T19029 30731-30740 Negative_regulation denotes deficient
T19030 30731-30740 Negative_regulation denotes deficient
T19031 30731-30740 Negative_regulation denotes deficient
T19032 31477-31486 Protein denotes ovalbumin
T19033 31496-31499 Protein denotes OVA
T19034 31542-31551 Protein denotes ovalbumin
T19035 31660-31663 Protein denotes MEK
T19036 31664-31674 Negative_regulation denotes inhibitors
T19037 31687-31690 Protein denotes p38
T19038 31691-31700 Negative_regulation denotes inhibitor
T19039 31716-31721 Protein denotes GSK3β
T19040 31722-31731 Negative_regulation denotes inhibitor
T19870 31818-31821 Protein denotes CD4
T19871 31927-31930 Protein denotes CD4
T19872 31931-31936 Protein denotes CD62L
T19873 31940-31943 Protein denotes CD4
T19874 31944-31949 Protein denotes CD62L
T19875 31951-31955 Protein denotes CD25
T19876 31961-31964 Protein denotes CD4
T19877 31965-31969 Protein denotes CD44
T19878 31971-31975 Protein denotes CD25
T19879 32148-32151 Protein denotes CD4
T19880 32282-32287 Protein denotes CD11c
T19881 32346-32349 Protein denotes CD4
T19882 32544-32547 Protein denotes OVA
T19883 32555-32560 Protein denotes IL-12
T19884 32603-32606 Protein denotes CD4
T19885 32666-32669 Protein denotes CD3
T19886 32679-32683 Protein denotes CD28
T19887 33176-33179 Protein denotes MEK
T19888 33180-33190 Negative_regulation denotes inhibitors
T19889 33203-33206 Protein denotes p38
T19890 33207-33216 Negative_regulation denotes inhibitor
T19891 33228-33233 Protein denotes GSK3β
T19892 33234-33243 Negative_regulation denotes inhibitor
T20205 33480-33483 Protein denotes CD3
T20206 33503-33507 Protein denotes CD28
T20207 33842-33846 Protein denotes IL-4
T20208 33848-33853 Protein denotes IL-10
T20209 33859-33864 Protein denotes IFN-γ
T20597 34095-34099 Protein denotes STAT
T20598 34100-34109 Negative_regulation denotes deficient
T20599 34180-34183 Protein denotes OVA
T20600 34362-34365 Protein denotes OVA
T20601 34565-34571 Protein denotes KJ1-26
T20602 34584-34587 Protein denotes CD4
T20603 34610-34615 Protein denotes IFN-γ
T20604 34620-34625 Protein denotes IL-10
T20851 34797-34800 Protein denotes CD3
T20852 34821-34825 Protein denotes CD28
T20853 35193-35202 Protein denotes ubiquitin
T20854 35206-35210 Protein denotes HPRT
T20855 35211-35222 Transcription denotes mRNA levels
T20856 35211-35222 Transcription denotes mRNA levels
T20996 35269-35272 Protein denotes CD4
T20997 35496-35499 Protein denotes ERK
T20998 35504-35509 Protein denotes actin
R512 T721 T722 themeOf Interleukin-10,Production
R513 T722 T723 themeOf Production,Requires
R514 T722 T724 themeOf Production,Requires
R515 T725 T726 causeOf Interleukin-12,Induced
R516 T726 T723 causeOf Induced,Requires
R517 T727 T726 themeOf STAT4,Induced
R518 T728 T729 themeOf ERK,Activation
R519 T729 T724 causeOf Activation,Requires
R520 T733 T731 themeOf interleukin-10,producing
R521 T734 T733 equivalentTo IL-10,interleukin-10
R522 T735 T732 themeOf interferon-γ,producing
R523 T736 T735 equivalentTo IFN-γ,interferon-γ
R524 T737 T738 themeOf IL-10,producing
R525 T739 T740 themeOf IL-10,producing
R526 T741 T744 themeOf ERK1,phosphorylation
R527 T742 T743 themeOf ERK2,phosphorylation
R528 T745 T746 causeOf IL-12,induced
R529 T747 T748 themeOf STAT4,activation
R530 T748 T746 themeOf activation,induced
R531 T750 T751 themeOf IL-10,production
R532 T751 T749 themeOf production,enhanced
R533 T754 T755 themeOf IL-10,producing
R534 T755 T753 themeOf producing,required
R535 T756 T761 causeOf activation,requirement
R536 T757 T760 causeOf activation,requirement
R537 T758 T757 themeOf ERK1,activation
R538 T759 T756 themeOf ERK2,activation
R539 T762 T760 themeOf production,requirement
R540 T762 T761 themeOf production,requirement
R541 T763 T762 themeOf IL-10,production
R542 T764 T765 themeOf IL-10,expression
R543 T766 T767 themeOf c-maf,expression
R544 T768 T769 themeOf IL-10,production
R1880 T2489 T2488 themeOf amounts,drive
R1881 T2490 T2489 themeOf IFN-γ,amounts
R1882 T2494 T2493 themeOf IL-4,expression
R1883 T2452 T2451 equivalentTo IL-10,erleukin-10
R1884 T2494 T2503 themeOf IL-4,requires
R1885 T2494 T2500 themeOf IL-4,requires
R1886 T2494 T2498 themeOf IL-4,requires
R1887 T2495 T2492 themeOf IL-5,expression
R1888 T2454 T2455 themeOf IL-10,expressed
R1889 T2495 T2499 themeOf IL-5,requires
R1890 T2495 T2497 themeOf IL-5,requires
R1891 T2495 T2501 themeOf IL-5,requires
R1892 T2461 T2460 themeOf interferon-γ,produce
R1893 T2496 T2491 themeOf IL-13,expression
R1894 T2462 T2461 equivalentTo IFN-γ,interferon-γ
R1895 T2463 T2459 themeOf IL-10,produce
R1896 T2496 T2505 themeOf IL-13,requires
R1897 T2496 T2502 themeOf IL-13,requires
R1898 T2496 T2504 themeOf IL-13,requires
R1899 T2467 T2466 themeOf IFN-γ,coproducing
R1900 T2506 T2503 causeOf IL-4,requires
R1901 T2468 T2465 themeOf IL-10,coproducing
R1902 T2469 T2470 themeOf IL-10,production
R1903 T2471 T2474 themeOf IL-10,produced
R1904 T2472 T2473 themeOf IFN-γ,produced
R1905 T2475 T2476 themeOf signal transducer and activator of transcription (STAT)1 ,activation
R1906 T2476 T2478 themeOf activation,induced
R1907 T2476 T2477 themeOf activation,induced
R1908 T2476 T2488 causeOf activation,drive
R1909 T2506 T2499 causeOf IL-4,requires
R1910 T2479 T2478 causeOf type I IFN,induced
R1911 T2480 T2477 causeOf IFN-γ,induced
R1912 T2506 T2505 causeOf IL-4,requires
R1913 T2507 T2500 causeOf STAT6,requires
R1914 T2482 T2481 equivalentTo T-bet,T-box 21
R1915 T2507 T2497 causeOf STAT6,requires
R1916 T2485 T2486 causeOf IL-18,induced
R1917 T2507 T2502 causeOf STAT6,requires
R1918 T2508 T2498 causeOf GATA binding protein (GATA)-3,requires
R1919 T2487 T2486 themeOf IRAK,induced
R1920 T2508 T2501 causeOf GATA binding protein (GATA)-3,requires
R1921 T2508 T2504 causeOf GATA binding protein (GATA)-3,requires
R1922 T2511 T2512 causeOf STAT3,dependent
R1923 T2513 T2512 themeOf expression,dependent
R1924 T2514 T2513 themeOf RORγt,expression
R1925 T2516 T2515 themeOf producing,result
R1926 T2516 T2519 themeOf producing,independent
R1927 T2517 T2516 themeOf IFN-γ,producing
R1928 T2518 T2519 causeOf IL-12,independent
R1929 T2520 T2523 themeOf ERK1,activation
R1930 T2521 T2522 themeOf ERK2,activation
R1932 T2522 T2525 causeOf activation,favor
R1933 T2523 T2524 causeOf activation,favor
R1936 T2526 T2527 themeOf IL-4,secretion
R1938 T2527 T2524 themeOf secretion,favor
R1939 T2527 T2525 themeOf secretion,favor
R1942 T2528 T2529 themeOf IL-10,produced
R1946 T2528 T2530 causeOf IL-10,act as a feedback regulator
R1947 T2529 T2530 themeOf produced,act as a feedback regulator
R1948 T2531 T2532 themeOf IL-10,production
R1951 T2532 T2533 themeOf production,induced
R1952 T2534 T2535 themeOf IL-10,producing
R1953 T2539 T2542 themeOf ERK1,phosphorylation
R1954 T2540 T2541 themeOf ERK2,phosphorylation
R1959 T2543 T2548 causeOf activation,requirement
R1962 T2544 T2547 causeOf activation,requirement
R1963 T2545 T2544 themeOf ERK1,activation
R1966 T2546 T2543 themeOf ERK2,activation
R1969 T2549 T2547 themeOf production,requirement
R1976 T2549 T2548 themeOf production,requirement
R1978 T2550 T2549 themeOf IL-10,production
R1981 T2551 T2552 themeOf IL-10,induction
R3405 T4450 T4449 themeOf IL-10,Producing
R3410 T4453 T4452 themeOf IFN-γ,coproducing
R3415 T4454 T4451 themeOf IL-10,coproducing
R3418 T4457 T4456 equivalentTo OVA,ovalbumin
R3423 T4460 T4458 themeOf expressing,rise
R3429 T4461 T4459 themeOf expressing,rise
R3431 T4462 T4461 themeOf IFN-γ,expressing
R3432 T4463 T4460 themeOf IL-10,expressing
R3433 T4466 T4465 themeOf IL-4,expressed
R3434 T4467 T4464 themeOf IL-10,expressed
R3435 T4526 T4528 themeOf recombination-activating gene 1,deficient
R3436 T4471 T4473 causeOf IL-12,resulted
R3437 T4527 T4526 equivalentTo Rag1,recombination-activating gene 1
R3438 T4529 T4530 causeOf IL-12,resulted
R3439 T4531 T4532 themeOf IL-10,expression
R3440 T4471 T4472 causeOf IL-12,resulted
R3441 T4532 T4530 themeOf expression,resulted
R3442 T4532 T4533 themeOf expression,dependent
R3443 T4534 T4535 causeOf TGF-β,induce
R3444 T4474 T4475 themeOf IFN-γ,producing
R3445 T4536 T4535 themeOf IL-10,induce
R3446 T4538 T4540 causeOf neutralization,increased
R3447 T4539 T4538 themeOf TGF-β,neutralization
R3448 T4541 T4542 themeOf IL-10,production
R3449 T4475 T4473 themeOf producing,resulted
R3450 T4542 T4540 themeOf production,increased
R3451 T4543 T4544 themeOf IL-10,producing
R3452 T4544 T4546 themeOf producing,depended
R3453 T4544 T4545 themeOf producing,depended
R3454 T4544 T4547 themeOf producing,depended
R3455 T4476 T4472 themeOf coproduced,resulted
R3456 T4477 T4476 themeOf IL-10,coproduced
R3457 T4548 T4546 causeOf IL-12,depended
R3458 T4549 T4545 causeOf IL-2,depended
R3459 T4479 T4482 themeOf lack,resulted
R3460 T4550 T4547 causeOf TGF-β,depended
R3461 T4480 T4479 themeOf IL-10,lack
R3462 T4480 T4481 themeOf IL-10,produced
R3463 T4483 T4482 causeOf inhibition,resulted
R3464 T4484 T4485 themeOf IL-10,production
R3465 T4485 T4483 themeOf production,inhibition
R3466 T4489 T4490 causeOf IL-12,induced
R3468 T4489 T4491 causeOf IL-12,induced
R3469 T4492 T4493 themeOf IFN-γ,expression
R3471 T4493 T4490 themeOf expression,induced
R3472 T4494 T4495 themeOf IL-10,expression
R3474 T4495 T4491 themeOf expression,induced
R3476 T4496 T4497 causeOf IL-12,induce
R3479 T4498 T4499 themeOf IL-10,production
R3480 T4499 T4497 themeOf production,induce
R3483 T4501 T4502 themeOf IL-10,producing
R3486 T4503 T4504 themeOf produced,more
R3490 T4505 T4503 themeOf IL-10,produced
R3493 T4506 T4508 themeOf producing,required
R3497 T4507 T4506 themeOf IL-10,producing
R3501 T4509 T4508 causeOf IL-12,required
R3503 T4512 T4510 themeOf IL-10,produce
R3506 T4513 T4511 themeOf IFN-γ,produce
R3509 T4515 T4514 themeOf produce,lost
R3512 T4516 T4515 themeOf IL-2,produce
R3513 T4519 T4520 themeOf IL-10,production
R3517 T4521 T4522 themeOf IL-10,producing
R3519 T4524 T4523 themeOf IL-2,limited
R5078 T6671 T6672 themeOf IL-10,Production
R5080 T6672 T6673 themeOf Production,Dependent
R5083 T6678 T6680 themeOf producing,role
R5084 T6679 T6678 themeOf IL-10,producing
R5087 T6681 T6680 causeOf STAT4,role
R5088 T6681 T6682 themeOf STAT4,activated
R5090 T6683 T6682 causeOf IL-12,activated
R5092 T6686 T6685 themeOf STAT4,deficient
R5093 T6689 T6690 themeOf IL-10,producing
R5095 T6692 T6696 causeOf absence,diminished
R5096 T6692 T6697 causeOf absence,increase
R5097 T6692 T6698 causeOf absence,increase
R5098 T6693 T6692 themeOf STAT4,absence
R5099 T6694 T6696 themeOf expressing,diminished
R5101 T6695 T6694 themeOf IFN-γ,expressing
R5103 T6699 T6698 themeOf expressing,increase
R5104 T6700 T6697 themeOf expressing,increase
R5105 T6701 T6700 themeOf IL-4,expressing
R5106 T6702 T6699 themeOf IL-10,expressing
R5107 T6703 T6704 causeOf STAT4,contributes
R5108 T6705 T6706 themeOf IL-10,expression
R5110 T6706 T6704 themeOf expression,contributes
R5111 T6707 T6708 themeOf IL-10,expression
R5113 T6710 T6711 themeOf IL-10,producing
R5115 T6713 T6714 themeOf STAT6,activation
R5117 T6716 T6715 themeOf STAT6,absence
R5119 T6717 T6718 themeOf IL-10,producing
R5120 T6718 T6719 themeOf producing,in the presence of
R5121 T6718 T6720 themeOf producing,in the presence of
R5123 T6721 T6719 causeOf IL-12,in the presence of
R5124 T6722 T6720 causeOf OVA,in the presence of
R5126 T6723 T6724 themeOf STAT6,deficient
R5128 T6727 T6725 themeOf IL-10,produced
R5129 T6728 T6726 themeOf IFN-γ,produced
R5130 T6729 T6732 causeOf lack,abrogated
R5131 T6729 T6731 causeOf lack,abrogated
R5133 T6730 T6729 themeOf STAT6,lack
R5134 T6733 T6735 themeOf IL-4,production
R5136 T6734 T6736 themeOf IL-10,production
R5137 T6735 T6732 themeOf production,abrogated
R5138 T6736 T6731 themeOf production,abrogated
R5141 T6739 T6742 themeOf IL-10,production
R5142 T6740 T6741 themeOf IL-4,production
R5143 T6741 T6744 themeOf production,increased
R5145 T6742 T6743 themeOf production,increased
R5148 T6745 T6746 themeOf IL-10,expression
R5149 T6746 T6747 themeOf expression,depended
R5151 T6750 T6755 themeOf inability,due
R5152 T6751 T6752 themeOf STAT4,deficient
R5153 T6752 T6750 causeOf deficient,inability
R5154 T6753 T6750 themeOf produce,inability
R5156 T6754 T6753 themeOf IL-10,produce
R5157 T6756 T6755 causeOf absence,due
R5158 T6757 T6756 themeOf IFN-γ,absence
R5159 T6758 T6759 themeOf IFN-γ,deficient
R5161 T6763 T6765 themeOf secretion,induced
R5163 T6764 T6763 themeOf IL-10,secretion
R5164 T6766 T6767 themeOf IL-12,affected
R5165 T6768 T6767 causeOf absence,affected
R5167 T6769 T6768 themeOf IFN-γ,absence
R5168 T6770 T6772 themeOf expression,independent
R5170 T6771 T6770 themeOf IL-10,expression
R5172 T6773 T6772 causeOf IFN-γ,independent
R5173 T6774 T6776 causeOf absence,increase
R5175 T6775 T6774 themeOf IFN-γ,absence
R5176 T6777 T6776 themeOf secreted,increase
R5177 T6778 T6777 themeOf IL-4,secreted
R5178 T6780 T6779 causeOf IL-4,role
R5179 T6781 T6779 themeOf producing,role
R5181 T6782 T6781 themeOf IL-10,producing
R5182 T6783 T6784 themeOf IL-4,deficient
R5183 T6788 T6787 themeOf STAT6,absence
R5184 T6789 T6790 themeOf IL-4,deficiency
R5186 T6792 T6791 themeOf IL-10,producing
R5188 T6794 T6793 themeOf IL-10,producing
R5189 T6795 T6796 themeOf IL-10,production
R5191 T6797 T6799 causeOf STAT4,induction
R5193 T6800 T6801 themeOf IL-10,production
R5194 T6801 T6799 themeOf production,induction
R5195 T6801 T6798 themeOf production,induction
R5196 T6802 T6798 causeOf STAT6,induction
R5858 T7660 T7661 themeOf IL-10,Producing
R5859 T7663 T7664 themeOf IL-10,production
R5860 T7664 T7662 themeOf production,regulating
R5861 T7669 T7672 themeOf IL-10,production
R5862 T7670 T7671 themeOf IFN-γ,production
R5863 T7671 T7668 themeOf production,induced
R5864 T7672 T7667 themeOf production,induced
R5865 T7673 T7674 themeOf IL-10,production
R5866 T7674 T7675 themeOf production,enhanced
R5867 T7676 T7675 causeOf OVA,enhanced
R5868 T7679 T7680 themeOf IL-10,producing
R5869 T7681 T7683 themeOf STAT4,deficient
R5870 T7682 T7684 themeOf STAT6,deficient
R5871 T7686 T7690 themeOf expression,reduced
R5872 T7686 T7693 themeOf expression,completely abrogated
R5873 T7687 T7691 themeOf expression,reduced
R5874 T7687 T7692 themeOf expression,completely abrogated
R5875 T7688 T7687 themeOf IL-10,expression
R5876 T7689 T7686 themeOf IFN-γ,expression
R5877 T7697 T7698 themeOf IL-10,production
R5878 T7698 T7696 themeOf production,effect
R5879 T7699 T7700 themeOf STAT6,deficient
R6872 T8961 T8962 themeOf IL-10,Production
R6873 T8962 T8963 themeOf Production,Maintained
R6874 T8964 T8963 causeOf IL-12,Maintained
R6875 T8968 T8967 themeOf IL-10,induction
R6876 T8971 T8972 causeOf IL-12,induce
R6877 T8973 T8974 themeOf IL-10,production
R6878 T8974 T8972 themeOf production,induce
R6879 T8975 T8976 themeOf IL-10,producing
R6880 T8979 T8978 themeOf production,resulted
R6881 T8980 T8979 themeOf IL-10,production
R6882 T8982 T8981 causeOf IL-12,need
R6883 T8983 T8984 themeOf IL-10,induction
R6884 T8984 T8981 themeOf induction,need
R6885 T8985 T8986 themeOf IL-10,induction
R6886 T8986 T8987 themeOf induction,abrogated
R6887 T8988 T8989 themeOf IL-12p40,deficient
R6888 T8989 T8987 causeOf deficient,abrogated
R6889 T8990 T8991 causeOf IL-12,essential
R6890 T8992 T8991 themeOf production,essential
R6891 T8993 T8992 themeOf IL-10,production
R6892 T8994 T8995 themeOf IL-10,producing
R6893 T9000 T8999 themeOf produce,induced
R6894 T9001 T9000 themeOf IL-10,produce
R6895 T9002 T8999 causeOf IL-12,induced
R6896 T9003 T9007 themeOf lost,compensated
R6897 T9004 T9003 themeOf express,lost
R6898 T9005 T9004 themeOf IL-10,express
R6899 T9006 T9003 causeOf OVA,lost
R6900 T9009 T9007 causeOf IL-12,compensated
R6901 T9009 T9008 themeOf IL-12,addition
R6902 T9012 T9011 themeOf induction,cooperate
R6903 T9013 T9012 themeOf IL-10,induction
R6904 T9018 T9016 themeOf IFN-γ,produced
R6905 T9019 T9017 themeOf IL-10,produced
R6906 T9021 T9020 themeOf produce,induced
R6907 T9022 T9021 themeOf IL-10,produce
R6908 T9023 T9020 causeOf IL-12,induced
R6909 T9024 T9025 causeOf IL-12,induction
R6910 T9026 T9027 themeOf IL-10,production
R6911 T9027 T9025 themeOf production,induction
R8254 T10687 T10688 themeOf IL-10,Production
R8255 T10693 T10695 themeOf ERK1,Activation
R8256 T10694 T10696 themeOf ERK2,Activation
R8257 T10695 T10691 causeOf Activation,Requires
R8258 T10695 T10692 causeOf Activation,Requires
R8259 T10696 T10690 causeOf Activation,Requires
R8260 T10696 T10689 causeOf Activation,Requires
R8261 T10697 T10700 themeOf maintenance,required
R8262 T10698 T10699 themeOf IL-10,induction
R8263 T10699 T10697 themeOf induction,maintenance
R8264 T10702 T10701 themeOf IL-12,addition
R8265 T10705 T10707 themeOf ERK1,activation
R8266 T10706 T10708 themeOf ERK2,activation
R8267 T10707 T10704 themeOf activation,induced
R8268 T10707 T10709 themeOf activation,induced
R8269 T10708 T10703 themeOf activation,induced
R8270 T10708 T10710 themeOf activation,induced
R8271 T10713 T10716 themeOf ERK1,activation
R8272 T10714 T10715 themeOf ERK2,activation
R8273 T10721 T10724 themeOf ERK1,activation
R8274 T10722 T10723 themeOf ERK2,activation
R8275 T10723 T10717 themeOf activation,enhanced
R8276 T10723 T10719 themeOf activation,prolonged
R8277 T10724 T10718 themeOf activation,enhanced
R8278 T10724 T10720 themeOf activation,prolonged
R8279 T10725 T10718 causeOf IL-12,enhanced
R8280 T10725 T10717 causeOf IL-12,enhanced
R8281 T10726 T10729 themeOf ERK1,activation
R8282 T10727 T10728 themeOf ERK2,activation
R8283 T10728 T10731 causeOf activation,required
R8284 T10729 T10730 causeOf activation,required
R8285 T10732 T10730 themeOf induction,required
R8286 T10732 T10731 themeOf induction,required
R8287 T10733 T10732 themeOf IL-10,induction
R8288 T10739 T10738 themeOf IL-10,producing
R8289 T10740 T10737 themeOf IFN-γ,producing
R8290 T10742 T10741 themeOf production,abrogated
R8291 T10743 T10742 themeOf IL-10,production
R8292 T10750 T10751 causeOf MEK5,catalyzed
R8293 T10751 T10745 themeOf catalyzed,inhibits
R8294 T10752 T10751 themeOf activation,catalyzed
R8295 T10753 T10752 themeOf ERK5,activation
R8296 T10754 T10759 causeOf MEK1,catalyzed
R8297 T10754 T10757 causeOf MEK1,catalyzed
R8298 T10755 T10756 causeOf MEK2,catalyzed
R8299 T10755 T10758 causeOf MEK2,catalyzed
R8300 T10756 T10749 themeOf catalyzed,inhibits
R8301 T10757 T10748 themeOf catalyzed,inhibits
R8302 T10758 T10747 themeOf catalyzed,inhibits
R8303 T10759 T10746 themeOf catalyzed,inhibits
R8304 T10760 T10759 themeOf activation,catalyzed
R8305 T10760 T10756 themeOf activation,catalyzed
R8306 T10761 T10757 themeOf activation,catalyzed
R8307 T10761 T10758 themeOf activation,catalyzed
R8308 T10762 T10760 themeOf ERK1,activation
R8309 T10763 T10761 themeOf ERK2,activation
R8310 T10764 T10766 themeOf MEK1,inhibitor
R8311 T10765 T10767 themeOf MEK2,inhibitor
R8312 T10771 T10770 themeOf MEK1,inhibits
R8313 T10772 T10769 themeOf MEK2,inhibits
R8314 T10773 T10768 themeOf MEK5,inhibits
R8315 T10775 T10776 themeOf IL-10,production
R8316 T10776 T10774 themeOf production,inhibition
R8317 T10777 T10778 themeOf p38 MAPK,inhibitor
R8318 T10778 T10781 causeOf inhibitor,effect
R8319 T10779 T10780 themeOf GSK3β,inhibitor
R8320 T10780 T10782 causeOf inhibitor,effect
R8321 T10783 T10784 themeOf IL-10,production
R8322 T10784 T10781 themeOf production,effect
R8323 T10784 T10782 themeOf production,effect
R8324 T10785 T10786 themeOf IL-10,production
R8325 T10786 T10787 themeOf production,in response to
R8326 T10787 T10789 themeOf in response to,requires
R8327 T10787 T10790 themeOf in response to,requires
R8328 T10788 T10787 causeOf IL-12,in response to
R8329 T10793 T10692 themeOf activation,Requires
R8330 T10793 T10689 themeOf activation,Requires
R8331 T10793 T10789 causeOf activation,requires
R8332 T10794 T10690 themeOf activation,Requires
R8333 T10794 T10790 causeOf activation,requires
R8334 T10794 T10691 themeOf activation,Requires
R8335 T10795 T10793 themeOf p38,activation
R8336 T10796 T10794 themeOf GSK3β,activation
R8924 T11552 T11553 themeOf IL-10,Production
R8925 T11553 T11554 themeOf Production,Requires
R8926 T11553 T11555 themeOf Production,Requires
R8927 T11556 T11558 themeOf ERK1,Activation
R8928 T11557 T11559 themeOf ERK2,Activation
R8929 T11558 T11554 causeOf Activation,Requires
R8930 T11559 T11555 causeOf Activation,Requires
R8931 T11560 T11561 themeOf IL-10,production
R8932 T11561 T11562 themeOf production,dependent
R8933 T11561 T11563 themeOf production,dependent
R8934 T11564 T11566 themeOf ERK1,activation
R8935 T11565 T11567 themeOf ERK2,activation
R8936 T11566 T11563 causeOf activation,dependent
R8937 T11567 T11562 causeOf activation,dependent
R8938 T11570 T11571 themeOf MEK,inhibitor
R8939 T11572 T11575 themeOf ERK1,activation
R8940 T11573 T11574 themeOf ERK2,activation
R8941 T11574 T11576 causeOf activation,required
R8942 T11575 T11577 causeOf activation,required
R8943 T11578 T11577 themeOf induction,required
R8944 T11578 T11576 themeOf induction,required
R8945 T11579 T11578 themeOf IL-10,induction
R8946 T11580 T11581 themeOf IL-10,production
R8947 T11581 T11582 themeOf production,inhibited
R8948 T11583 T11584 themeOf MEK,inhibitor
R8949 T11584 T11582 causeOf inhibitor,inhibited
R8950 T11585 T11592 causeOf inhibitors,affect
R8951 T11586 T11591 causeOf inhibitors,affect
R8952 T11587 T11590 themeOf p38 MAPK,activation
R8953 T11588 T11589 themeOf GSK-3β,activation
R8954 T11589 T11585 themeOf activation,inhibitors
R8955 T11590 T11586 themeOf activation,inhibitors
R8956 T11593 T11591 themeOf expression,affect
R8957 T11593 T11592 themeOf expression,affect
R8958 T11594 T11593 themeOf IL-10,expression
R8959 T11598 T11597 themeOf induction,requirement
R8960 T11599 T11600 themeOf IL-10,production
R8961 T11600 T11598 themeOf production,induction
R10422 T13326 T13327 themeOf c-maf,Expression
R10423 T13328 T13329 themeOf IL-10,Production
R10424 T13331 T13332 themeOf IL-10,production
R10425 T13332 T13330 themeOf production,regulating
R10426 T13336 T13339 themeOf resulted,abrogated
R10427 T13337 T13336 themeOf transcription,resulted
R10428 T13338 T13337 themeOf Il4,transcription
R10429 T13340 T13339 causeOf IL-12,abrogated
R10430 T13341 T13343 themeOf transcription,induced
R10431 T13341 T13345 themeOf transcription,this effect
R10432 T13342 T13341 themeOf Ifnγ,transcription
R10433 T13344 T13343 causeOf IL-12,induced
R10434 T13345 T13347 themeOf this effect,upregulated
R10435 T13346 T13345 causeOf IL-12,this effect
R10436 T13348 T13349 themeOf Il10,transcription
R10437 T13349 T13353 themeOf transcription,abrogated
R10438 T13350 T13351 themeOf Il4,expression
R10439 T13354 T13355 themeOf Il4,expression
R10440 T13355 T13352 themeOf expression,abrogated
R10441 T13356 T13357 causeOf IL-12,effect
R10442 T13358 T13357 themeOf increase,effect
R10443 T13359 T13360 themeOf IL-10,mRNA expression
R10444 T13360 T13358 themeOf mRNA expression,increase
R10445 T13361 T13362 causeOf IL-12,induced
R10446 T13361 T13363 causeOf IL-12,induced
R10447 T13364 T13365 themeOf Il10,transcription
R10448 T13365 T13362 themeOf transcription,induced
R10449 T13366 T13367 themeOf Ifnγ,expression
R10450 T13367 T13363 themeOf expression,induced
R10451 T13370 T13369 themeOf Tbx-21,express
R10452 T13371 T13370 equivalentTo T-bet,Tbx-21
R10453 T13373 T13374 themeOf GATA-3,mRNA expression
R10454 T13374 T13375 themeOf mRNA expression,downregulated
R10455 T13376 T13375 causeOf IL-12,downregulated
R10456 T13378 T13377 themeOf expression,led
R10457 T13378 T13380 themeOf expression,abrogated
R10458 T13379 T13378 themeOf c-maf,expression
R10459 T13381 T13382 causeOf IL-12,sustained
R10460 T13383 T13382 themeOf expression,sustained
R10461 T13384 T13383 themeOf c-Maf,expression
R10462 T13385 T13386 causeOf IL-12,maintenance
R10463 T13387 T13388 themeOf c-maf,expression
R10464 T13388 T13386 themeOf expression,maintenance
R10465 T13388 T13389 causeOf expression,required
R10466 T13390 T13391 themeOf STAT4,activation
R10467 T13391 T13389 themeOf activation,required
R10468 T13394 T13392 themeOf IL-17a,expressed
R10469 T13395 T13393 themeOf IL-10,expressed
R10470 T13396 T13399 themeOf T-bet,mRNA
R10471 T13397 T13398 themeOf GATA-3,mRNA
R10472 T13398 T13400 themeOf mRNA,undetectable
R10473 T13399 T13401 themeOf mRNA,undetectable
R10474 T13402 T13403 themeOf ROR-γt,high
R10475 T13405 T13404 themeOf c-maf,expressed
R10476 T13406 T13407 themeOf c-Maf,expressed
R10477 T13408 T13409 themeOf IL-10,expressing
R10478 T13410 T13411 themeOf Il10,expression
R10479 T13411 T13417 themeOf expression,inhibited
R10480 T13411 T13416 themeOf expression,inhibited
R10481 T13412 T13413 themeOf c-maf,expression
R10482 T13413 T13415 themeOf expression,inhibited
R10483 T13413 T13414 themeOf expression,inhibited
R10484 T13418 T13420 themeOf MEK1,inhibitor
R10485 T13419 T13421 themeOf MEK2,inhibitor
R10486 T13420 T13417 causeOf inhibitor,inhibited
R10487 T13420 T13415 causeOf inhibitor,inhibited
R10488 T13420 T13427 causeOf inhibitor,affected
R10489 T13420 T13428 causeOf inhibitor,affected
R10490 T13421 T13416 causeOf inhibitor,inhibited
R10491 T13421 T13414 causeOf inhibitor,inhibited
R10492 T13421 T13426 causeOf inhibitor,affected
R10493 T13421 T13429 causeOf inhibitor,affected
R10494 T13422 T13424 themeOf T-bet,expression
R10495 T13423 T13425 themeOf RORγt,expression
R10496 T13424 T13427 themeOf expression,affected
R10497 T13424 T13426 themeOf expression,affected
R10498 T13425 T13428 themeOf expression,affected
R10499 T13425 T13429 themeOf expression,affected
R14473 T18186 T18187 themeOf IL-10,expression
R14476 T18188 T18189 themeOf IL-10,expression
R14478 T18190 T18191 themeOf IL-10,produced
R14479 T18191 T18192 themeOf produced,in response to
R14483 T18194 T18193 themeOf IL-10,produce
R14487 T18198 T18201 themeOf ERK1,phosphorylation
R14488 T18199 T18200 themeOf ERK2,phosphorylation
R14489 T18200 T18197 causeOf phosphorylation,required
R14490 T18201 T18195 causeOf phosphorylation,required
R14492 T18202 T18203 causeOf IL-12,induced
R14494 T18204 T18205 themeOf STAT-4,activation
R14495 T18205 T18196 causeOf activation,required
R14496 T18205 T18203 themeOf activation,induced
R14497 T18206 T18195 themeOf produce,required
R14498 T18206 T18197 themeOf produce,required
R14499 T18206 T18196 themeOf produce,required
R14501 T18207 T18206 themeOf IL-10,produce
R14502 T18208 T18210 themeOf ERK1,activation
R14503 T18209 T18211 themeOf ERK2,activation
R14505 T18210 T18213 causeOf activation,required
R14506 T18211 T18212 causeOf activation,required
R14512 T18214 T18213 themeOf production,required
R14513 T18214 T18212 themeOf production,required
R14514 T18214 T18217 themeOf production,provides a highly regulated feedback loop
R14515 T18215 T18214 themeOf IL-10,production
R14516 T18216 T18217 causeOf IL-10,provides a highly regulated feedback loop
R14518 T18220 T18219 themeOf express,induced
R14520 T18221 T18220 themeOf IL-10,express
R14521 T18222 T18223 themeOf IL-10,producing
R14524 T18229 T18227 themeOf IL-10,coproduce
R14525 T18230 T18228 themeOf IFN-γ,coproduce
R14528 T18232 T18233 themeOf IL-10,production
R14530 T18314 T18315 themeOf IL-10,production
R14531 T18236 T18235 themeOf IL-10,producing
R14532 T18241 T18239 themeOf IFN-γ,expressing
R14533 T18242 T18240 themeOf IL-10,expressing
R14534 T18244 T18245 themeOf IL-2,expression
R14535 T18245 T18243 themeOf expression,lose
R14536 T18247 T18246 themeOf IL-2,loss
R14537 T18315 T18313 themeOf production,negatively regulate
R14538 T18249 T18248 themeOf IL-10,production
R14539 T18318 T18317 themeOf IL-10,induce
R14540 T18252 T18254 themeOf induction,reduced
R14541 T18253 T18252 themeOf IL-10,induction
R14542 T18255 T18256 themeOf STAT4,deficient
R14543 T18256 T18254 causeOf deficient,reduced
R14544 T18258 T18257 causeOf IL-12,requirement
R14545 T18259 T18257 themeOf induction,requirement
R14546 T18260 T18259 themeOf IL-10,induction
R14547 T18321 T18322 themeOf IL-4,production
R14548 T18262 T18261 themeOf IL-10,producing
R14549 T18264 T18265 themeOf IL-10,production
R14550 T18265 T18266 themeOf production,induced
R14551 T18266 T18268 themeOf induced,independent
R14552 T18267 T18266 causeOf IL-12,induced
R14553 T18322 T18320 themeOf production,regulates
R14554 T18269 T18268 causeOf IFN-γ,independent
R14555 T18323 T18326 themeOf ERK1,activation
R14556 T18270 T18271 causeOf IFN-γ,mediating
R14557 T18272 T18273 themeOf IL-10,reactivation
R14558 T18323 T18328 causeOf ERK1,regulation
R14559 T18273 T18271 themeOf reactivation,mediating
R14560 T18324 T18325 themeOf ERK2,activation
R14561 T18276 T18275 themeOf IL-10,express
R14562 T18277 T18281 themeOf induced,dependent
R14563 T18324 T18327 causeOf ERK2,regulation
R14564 T18278 T18277 themeOf produce,induced
R14565 T18329 T18330 themeOf IL-10,production
R14566 T18279 T18278 themeOf IL-10,produce
R14567 T18282 T18281 causeOf induction,dependent
R14568 T18283 T18282 themeOf IL-12,induction
R14569 T18284 T18285 causeOf IL-12,resulted
R14570 T18286 T18287 themeOf IL-10,production
R14571 T18330 T18328 themeOf production,regulation
R14572 T18287 T18285 themeOf production,resulted
R14573 T18288 T18291 themeOf ERK1,activation
R14574 T18289 T18290 themeOf ERK2,activation
R14575 T18330 T18327 themeOf production,regulation
R14576 T18331 T18332 themeOf IL-10,produced
R14577 T18292 T18295 causeOf increased,induce
R14578 T18293 T18292 themeOf expression,increased
R14579 T18332 T18333 themeOf produced,regulated
R14580 T18294 T18293 themeOf IFN-γ,expression
R14581 T18296 T18295 themeOf increased,induce
R14582 T18336 T18338 themeOf ERK1,activation
R14583 T18297 T18298 themeOf IL-12,production
R14584 T18298 T18296 themeOf production,increased
R14585 T18300 T18301 themeOf IL-12,production
R14586 T18301 T18299 themeOf production,upregulate
R14587 T18303 T18302 causeOf IFN-γ,requirement
R14588 T18337 T18339 themeOf ERK2,activation
R14589 T18304 T18302 themeOf induce,requirement
R14590 T18305 T18304 themeOf IL-10,induce
R14591 T18306 T18308 causeOf upregulation,induced
R14592 T18307 T18306 themeOf IL-12,upregulation
R14593 T18309 T18308 themeOf IL-10,induced
R14594 T18310 T18311 themeOf IL-10,regulated
R14595 T18338 T18335 causeOf activation,role
R14596 T18339 T18334 causeOf activation,role
R14597 T18340 T18335 themeOf induction,role
R14598 T18409 T18410 themeOf IL-10,production
R14599 T18410 T18408 themeOf production,required
R14600 T18410 T18407 themeOf production,required
R14601 T18412 T18411 themeOf IL-10,expression
R14602 T18340 T18334 themeOf induction,role
R14603 T18413 T18414 themeOf IL-10,expression
R14604 T18341 T18342 themeOf IL-10,production
R14605 T18414 T18415 themeOf expression,induced
R14606 T18342 T18340 themeOf production,induction
R14607 T18344 T18343 themeOf IL-10,regulation
R14608 T18414 T18416 themeOf expression,amplified
R14609 T18414 T18417 themeOf expression,regulated
R14610 T18347 T18348 themeOf IL-10,produced
R14611 T18418 T18416 causeOf IL-12,amplified
R14612 T18418 T18417 causeOf IL-12,regulated
R14613 T18420 T18419 themeOf production,regulate
R14614 T18347 T18349 themeOf IL-10,expression
R14615 T18421 T18420 themeOf IL-10,production
R14616 T18351 T18350 themeOf T-bet,expression
R14617 T18423 T18424 themeOf IL-10,production
R14618 T18424 T18422 themeOf production,regulation
R14619 T18352 T18353 themeOf IFN-γ,production
R14620 T18357 T18359 themeOf IL-10,expression
R14621 T18358 T18360 themeOf IFN-γ,expression
R14622 T18359 T18355 themeOf expression,required
R14623 T18360 T18356 themeOf expression,required
R14624 T18361 T18365 themeOf maintenance,conditional
R14626 T18361 T18364 themeOf maintenance,conditional
R14627 T18362 T18363 themeOf IL-10,expression
R14630 T18363 T18361 themeOf expression,maintenance
R14632 T18366 T18365 causeOf IL-12,conditional
R14634 T18367 T18364 causeOf IL-4,conditional
R14638 T18371 T18372 themeOf IL-10,produced
R14642 T18373 T18374 causeOf IL-12,downregulate
R14654 T18375 T18376 themeOf Gata-3,expression
R14659 T18376 T18374 themeOf expression,downregulate
R14660 T18378 T18379 themeOf IL-10,expression
R14662 T18379 T18377 themeOf expression,induce
R14664 T18380 T18382 themeOf Expression,diminished
R14667 T18380 T18383 themeOf Expression,maintained
R14668 T18381 T18380 themeOf c-maf,Expression
R14670 T18384 T18383 causeOf IL-12,maintained
R14672 T18385 T18386 themeOf c-maf,expression
R14674 T18385 T18394 themeOf c-maf,expression
R14677 T18386 T18391 themeOf expression,dependent
R14679 T18387 T18388 themeOf IL-10,producing
R14682 T18389 T18390 themeOf IL-10,dependent
R14684 T18392 T18393 themeOf ERK,activation
R14690 T18393 T18391 causeOf activation,dependent
R14695 T18393 T18390 causeOf activation,dependent
R14697 T18395 T18396 causeOf c-Maf,essential
R14700 T18397 T18398 themeOf IL-10,expression
R14702 T18398 T18396 themeOf expression,essential
R14704 T18401 T18400 themeOf make,induced
R14708 T18402 T18401 themeOf IL-10,make
R14712 T18403 T18406 themeOf ERK1,activation
R14715 T18403 T18408 causeOf ERK1,required
R14716 T18404 T18405 themeOf ERK2,activation
R14718 T18404 T18407 causeOf ERK2,required
R15082 T19022 T19030 themeOf Rag1,deficient
R15083 T19023 T19028 themeOf IL-4,deficient
R15084 T19024 T19027 themeOf IFN-γ,deficient
R15085 T19025 T19031 themeOf STAT4,deficient
R15086 T19026 T19029 themeOf STAT6,deficient
R15087 T19033 T19032 equivalentTo OVA,ovalbumin
R15088 T19035 T19036 themeOf MEK,inhibitors
R15089 T19037 T19038 themeOf p38,inhibitor
R15090 T19039 T19040 themeOf GSK3β,inhibitor
R15758 T19887 T19888 themeOf MEK,inhibitors
R15759 T19889 T19890 themeOf p38,inhibitor
R15760 T19891 T19892 themeOf GSK3β,inhibitor
R16334 T20597 T20598 themeOf STAT,deficient
R16540 T20853 T20855 themeOf ubiquitin,mRNA levels
R16541 T20854 T20856 themeOf HPRT,mRNA levels

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T770 71-76 Protein denotes STAT4
T771 102-116 Protein denotes ERK MAP Kinase
T772 131-143 Protein denotes High Antigen
T773 144-148 Entity denotes Dose
T774 117-127 Positive_regulation denotes Activation
T775 48-70 Positive_regulation denotes Interleukin-12-Induced
T776 168-172 Protein denotes CD4+
T777 191-205 Protein denotes interleukin-10
T778 207-212 Protein denotes IL-10
T779 218-230 Protein denotes interferon-γ
T780 232-237 Protein denotes IFN-γ
T781 181-190 Gene_expression denotes producing
T782 181-190 Gene_expression denotes producing
T783 181-190 Gene_expression denotes producing
T784 181-190 Gene_expression denotes producing
T785 451-466 Protein denotes T cell receptor
T786 468-471 Protein denotes TCR
T787 493-497 Protein denotes ERK1
T788 502-518 Protein denotes ERK2 MAP kinases
T789 554-559 Protein denotes STAT4
T790 473-481 Binding denotes ligation
T791 473-481 Binding denotes ligation
T792 519-534 Phosphorylation denotes phosphorylation
T793 519-534 Phosphorylation denotes phosphorylation
T794 581-591 Positive_regulation denotes activation
T795 437-445 Positive_regulation denotes required
T796 437-445 Positive_regulation denotes required
T797 437-445 Positive_regulation denotes required
T798 437-445 Positive_regulation denotes required
T799 437-445 Positive_regulation denotes required
T800 437-445 Positive_regulation denotes required
T801 540-553 Positive_regulation denotes IL-12-induced
T802 581-591 Positive_regulation denotes activation
T803 602-605 Protein denotes TCR
T804 633-638 Protein denotes IL-10
T805 678-683 Protein denotes IL-12
T806 606-616 Positive_regulation denotes triggering
T807 639-649 Gene_expression denotes production
T808 624-632 Positive_regulation denotes enhanced
T809 868-873 Protein denotes STATs
T810 915-919 Protein denotes ERK1
T811 924-928 Protein denotes ERK2
T812 972-977 Protein denotes IL-10
T813 845-855 Positive_regulation denotes activation
T814 901-911 Positive_regulation denotes activation
T815 901-911 Positive_regulation denotes activation
T816 958-968 Gene_expression denotes production
T817 833-840 Positive_regulation denotes require
T818 942-953 Positive_regulation denotes requirement
T819 942-953 Positive_regulation denotes requirement
T820 1002-1007 Protein denotes IL-10
T821 1040-1045 Protein denotes c-maf
T822 1008-1018 Gene_expression denotes expression
T823 1046-1056 Gene_expression denotes expression
T824 1221-1226 Protein denotes IL-10
T825 1227-1237 Gene_expression denotes production
T2553 1253-1267 Protein denotes Interleukin-10
T2554 1269-1274 Protein denotes IL-10
T2555 1687-1692 Protein denotes IL-10
T2556 1696-1705 Gene_expression denotes expressed
T2557 2244-2247 Protein denotes CD4
T2558 2253-2257 Protein denotes CD8+
T2559 2282-2285 Protein denotes CD4
T2560 2313-2325 Protein denotes interferon-γ
T2561 2327-2332 Protein denotes IFN-γ
T2562 2338-2343 Protein denotes IL-10
T2563 2370-2385 Protein denotes T cell receptor
T2564 2387-2390 Protein denotes TCR
T2565 2423-2428 Protein denotes IL-12
T2566 2300-2307 Gene_expression denotes produce
T2567 2300-2307 Gene_expression denotes produce
T2568 2300-2307 Gene_expression denotes produce
T2569 2581-2586 Protein denotes IFN-γ
T2570 2591-2596 Protein denotes IL-10
T2571 2569-2580 Gene_expression denotes coproducing
T2572 2569-2580 Gene_expression denotes coproducing
T2573 2720-2725 Protein denotes IL-10
T2574 2726-2736 Gene_expression denotes production
T2575 3058-3063 Protein denotes IL-10
T2576 3068-3073 Protein denotes IFN-γ
T2577 3074-3082 Gene_expression denotes produced
T2578 3074-3082 Gene_expression denotes produced
T2579 3571-3581 Protein denotes type I IFN
T2580 3585-3590 Protein denotes IFN-γ
T2581 3653-3658 Protein denotes STAT4
T2582 3692-3697 Protein denotes IL-18
T2583 3706-3710 Protein denotes IRAK
T2584 3715-3742 Protein denotes NF-κB transcription factors
T2585 3772-3777 Protein denotes IFN-γ
T2586 3698-3705 Positive_regulation denotes induced
T2587 3894-3898 Protein denotes IL-4
T2588 3900-3904 Protein denotes IL-5
T2589 3926-3930 Protein denotes IL-4
T2590 3932-3937 Protein denotes STAT6
T2591 3968-3988 Protein denotes GATA binding protein
T2592 3990-3994 Protein denotes GATA
T2593 3880-3890 Gene_expression denotes expression
T2594 3880-3890 Gene_expression denotes expression
T2595 3917-3925 Positive_regulation denotes requires
T2596 3917-3925 Positive_regulation denotes requires
T2597 4066-4070 Protein denotes IL-6
T2598 4072-4077 Protein denotes TGF-β
T2599 4087-4092 Protein denotes STAT3
T2600 4103-4113 Gene_expression denotes expression
T2601 4093-4102 Positive_regulation denotes dependent
T2602 4394-4397 Protein denotes TCR
T2603 4444-4447 Protein denotes ERK
T2604 4449-4481 Protein denotes mitogen-activated protein kinase
T2605 4483-4487 Protein denotes MAPK
T2606 4536-4541 Protein denotes IFN-γ
T2607 4615-4619 Protein denotes ERK1
T2608 4624-4628 Protein denotes ERK2
T2609 4665-4669 Protein denotes IL-4
T2610 4433-4442 Regulation denotes regulated
T2611 4433-4442 Regulation denotes regulated
T2612 4433-4442 Regulation denotes regulated
T2613 4489-4504 Phosphorylation denotes phosphorylation
T2614 4489-4504 Phosphorylation denotes phosphorylation
T2615 4489-4504 Phosphorylation denotes phosphorylation
T2616 4489-4504 Phosphorylation denotes phosphorylation
T2617 4506-4512 Positive_regulation denotes result
T2618 4506-4512 Positive_regulation denotes result
T2619 4506-4512 Positive_regulation denotes result
T2620 4506-4512 Positive_regulation denotes result
T2621 4526-4535 Gene_expression denotes producing
T2622 4526-4535 Gene_expression denotes producing
T2623 4629-4639 Positive_regulation denotes activation
T2624 4629-4639 Positive_regulation denotes activation
T2625 4629-4639 Positive_regulation denotes activation
T2626 4670-4679 Localization denotes secretion
T2627 4433-4442 Regulation denotes regulated
T2628 4433-4442 Regulation denotes regulated
T2629 4433-4442 Regulation denotes regulated
T2630 4433-4442 Regulation denotes regulated
T2631 4506-4512 Positive_regulation denotes result
T2632 4506-4512 Positive_regulation denotes result
T2633 5004-5009 Protein denotes IL-10
T2634 5010-5018 Gene_expression denotes produced
T2635 5389-5393 Protein denotes CD4+
T2636 5425-5430 Protein denotes STAT4
T2637 5449-5452 Protein denotes TCR
T2638 5499-5503 Protein denotes ERK1
T2639 5508-5512 Protein denotes ERK2
T2640 5513-5528 Phosphorylation denotes phosphorylation
T2641 5513-5528 Phosphorylation denotes phosphorylation
T2642 5453-5463 Positive_regulation denotes activation
T2643 5453-5463 Positive_regulation denotes activation
T2644 5572-5576 Protein denotes ERK1
T2645 5581-5585 Protein denotes ERK2
T2646 5621-5626 Protein denotes IL-10
T2647 5630-5633 Protein denotes Th1
T2648 5635-5638 Protein denotes Th2
T2649 5558-5568 Positive_regulation denotes activation
T2650 5558-5568 Positive_regulation denotes activation
T2651 5607-5617 Gene_expression denotes production
T2652 5607-5617 Gene_expression denotes production
T2653 5607-5617 Gene_expression denotes production
T2654 5591-5602 Positive_regulation denotes requirement
T2655 5591-5602 Positive_regulation denotes requirement
T2656 5591-5602 Positive_regulation denotes requirement
T2657 5591-5602 Positive_regulation denotes requirement
T2658 5591-5602 Positive_regulation denotes requirement
T2659 5591-5602 Positive_regulation denotes requirement
T2660 5708-5713 Protein denotes IL-10
T2661 5714-5723 Positive_regulation denotes induction
T4551 5900-5905 Protein denotes IL-12
T4552 6038-6043 Protein denotes IFN-γ
T4553 6048-6053 Protein denotes IL-10
T4554 6105-6109 Protein denotes CD4+
T4555 6168-6177 Protein denotes ovalbumin
T4556 6026-6037 Gene_expression denotes coproducing
T4557 6026-6037 Gene_expression denotes coproducing
T4558 6260-6263 Protein denotes Th1
T4559 6281-6286 Protein denotes IFN-γ
T4560 6270-6280 Gene_expression denotes expressing
T4561 6270-6280 Gene_expression denotes expressing
T4562 6516-6520 Protein denotes IL-4
T4563 6525-6530 Protein denotes IL-10
T4564 6501-6510 Gene_expression denotes expressed
T4565 6501-6510 Gene_expression denotes expressed
T4566 6581-6585 Protein denotes CD4+
T4567 6636-6644 Protein denotes anti-CD3
T4568 6649-6669 Protein denotes anti-CD28 antibodies
T4569 6689-6694 Protein denotes IL-12
T4570 6707-6712 Protein denotes IFN-γ
T4571 6767-6772 Protein denotes IL-10
T4572 6619-6630 Positive_regulation denotes stimulation
T4573 6713-6722 Gene_expression denotes producing
T4574 6756-6766 Gene_expression denotes coproduced
T4575 6871-6876 Protein denotes IL-10
T4576 6927-6932 Protein denotes IL-10
T4577 7024-7028 Protein denotes CD4+
T4578 7105-7110 Protein denotes IL-12
T4579 6863-6867 Negative_regulation denotes lack
T4580 6877-6885 Gene_expression denotes produced
T4581 6899-6907 Positive_regulation denotes resulted
T4582 6933-6943 Gene_expression denotes production
T4583 6863-6867 Negative_regulation denotes lack
T4584 6913-6923 Negative_regulation denotes inhibition
T4585 7194-7199 Protein denotes IFN-γ
T4586 7234-7239 Protein denotes IL-10
T4587 7322-7327 Protein denotes IL-10
T4588 7200-7210 Gene_expression denotes expression
T4589 7240-7250 Gene_expression denotes expression
T4590 7328-7338 Gene_expression denotes production
T4591 7186-7193 Positive_regulation denotes induced
T4592 7186-7193 Positive_regulation denotes induced
T4593 7303-7309 Positive_regulation denotes induce
T4594 7440-7445 Protein denotes IL-12
T4595 7530-7543 Protein denotes IL-10 protein
T4596 7516-7524 Gene_expression denotes produced
T4597 7629-7634 Protein denotes IL-10
T4598 7649-7654 Protein denotes IL-12
T4599 7619-7628 Gene_expression denotes producing
T4600 7635-7643 Positive_regulation denotes required
T4601 7735-7740 Protein denotes IL-10
T4602 7745-7750 Protein denotes IFN-γ
T4603 7710-7717 Gene_expression denotes produce
T4604 7710-7717 Gene_expression denotes produce
T4605 7828-7833 Protein denotes IL-12
T4606 7863-7867 Protein denotes CD4+
T4607 8064-8068 Protein denotes CD4+
T4608 8115-8121 Protein denotes gene 1
T4609 8123-8127 Protein denotes Rag1
T4610 8203-8208 Protein denotes IL-12
T4611 8227-8232 Protein denotes IL-10
T4612 8128-8138 Negative_regulation denotes -deficient
T4613 8128-8138 Negative_regulation denotes -deficient
T4614 8233-8243 Gene_expression denotes expression
T4615 8215-8223 Positive_regulation denotes resulted
T4616 8414-8419 Protein denotes TGF-β
T4617 8431-8436 Protein denotes IL-10
T4618 8440-8444 Protein denotes CD4+
T4619 8424-8430 Positive_regulation denotes induce
T4620 8611-8616 Protein denotes TGF-β
T4621 8634-8639 Protein denotes IL-10
T4622 8593-8607 Negative_regulation denotes neutralization
T4623 8640-8650 Gene_expression denotes production
T4624 8624-8633 Positive_regulation denotes increased
T4625 8771-8776 Protein denotes IL-12
T4626 8850-8854 Protein denotes IL-2
T4627 8858-8863 Protein denotes TGF-β
T6803 8907-8912 Protein denotes IL-10
T6804 8953-8958 Protein denotes STAT4
T6805 8970-8975 Protein denotes STAT6
T6806 8977-8982 Protein denotes IFN-γ
T6807 8987-8991 Protein denotes IL-4
T6808 8913-8923 Gene_expression denotes Production
T6809 8940-8949 Positive_regulation denotes Dependent
T6810 9090-9095 Protein denotes IL-10
T6811 9125-9130 Protein denotes STAT4
T6812 9080-9089 Gene_expression denotes producing
T6813 9117-9121 Regulation denotes role
T6814 9162-9171 Positive_regulation denotes activated
T6815 9244-9249 Protein denotes STAT4
T6816 9305-9310 Protein denotes IL-12
T6817 9231-9240 Negative_regulation denotes deficient
T6818 9486-9491 Protein denotes STAT4
T6819 9528-9533 Protein denotes IFN-γ
T6820 9640-9644 Protein denotes IL-4
T6821 9689-9694 Protein denotes STAT4
T6822 9710-9715 Protein denotes IL-10
T6823 9475-9482 Negative_regulation denotes absence
T6824 9517-9527 Gene_expression denotes expressing
T6825 9551-9561 Negative_regulation denotes diminished
T6826 9629-9639 Gene_expression denotes expressing
T6827 9716-9726 Gene_expression denotes expression
T6828 9593-9601 Positive_regulation denotes increase
T6829 9695-9706 Positive_regulation denotes contributes
T6830 9749-9754 Protein denotes IL-10
T6831 9932-9945 Protein denotes IL-4 receptor
T6832 9950-9955 Protein denotes STAT6
T6833 9755-9765 Gene_expression denotes expression
T6834 9956-9966 Positive_regulation denotes activation
T6835 10032-10037 Protein denotes STAT6
T6836 10121-10126 Protein denotes IL-12
T6837 10021-10028 Negative_regulation denotes absence
T6838 10180-10185 Protein denotes STAT6
T6839 10239-10244 Protein denotes IL-10
T6840 10249-10254 Protein denotes IFN-γ
T6841 10186-10195 Negative_regulation denotes deficient
T6842 10225-10233 Gene_expression denotes produced
T6843 10225-10233 Gene_expression denotes produced
T6844 10371-10376 Protein denotes STAT6
T6845 10392-10396 Protein denotes IL-4
T6846 10401-10406 Protein denotes IL-10
T6847 10444-10448 Protein denotes IL-4
T6848 10363-10367 Negative_regulation denotes lack
T6849 10407-10417 Gene_expression denotes production
T6850 10407-10417 Gene_expression denotes production
T6851 10377-10386 Negative_regulation denotes abrogated
T6852 10377-10386 Negative_regulation denotes abrogated
T6853 10522-10527 Protein denotes STAT4
T6854 10539-10544 Protein denotes IL-10
T6855 10549-10553 Protein denotes IL-4
T6856 10554-10564 Gene_expression denotes production
T6857 10554-10564 Gene_expression denotes production
T6858 10594-10603 Positive_regulation denotes increased
T6859 10594-10603 Positive_regulation denotes increased
T6860 10686-10691 Protein denotes IL-10
T6861 10728-10733 Protein denotes STAT6
T6862 10746-10751 Protein denotes STAT4
T6863 10692-10702 Gene_expression denotes expression
T6864 10716-10724 Positive_regulation denotes depended
T6865 10824-10829 Protein denotes STAT4
T6866 10859-10864 Protein denotes IL-10
T6867 10896-10901 Protein denotes IFN-γ
T6868 10973-10986 Protein denotes DO11.10 IFN-γ
T6869 11003-11007 Protein denotes CD4+
T6870 10830-10839 Negative_regulation denotes deficient
T6871 10851-10858 Gene_expression denotes produce
T6872 10885-10892 Negative_regulation denotes absence
T6873 10987-10996 Negative_regulation denotes deficient
T6874 10811-10820 Negative_regulation denotes inability
T6875 11087-11092 Protein denotes IL-10
T6876 11130-11135 Protein denotes IL-12
T6877 11170-11175 Protein denotes IFN-γ
T6878 11220-11225 Protein denotes IL-10
T6879 11229-11232 Protein denotes Th1
T6880 11257-11262 Protein denotes IFN-γ
T6881 11074-11083 Localization denotes secretion
T6882 11074-11083 Localization denotes secretion
T6883 11096-11103 Positive_regulation denotes induced
T6884 11096-11103 Positive_regulation denotes induced
T6885 11096-11103 Positive_regulation denotes induced
T6886 11159-11166 Negative_regulation denotes absence
T6887 11206-11216 Gene_expression denotes expression
T6888 11242-11253 Positive_regulation denotes independent
T6889 11144-11152 Regulation denotes affected
T6890 11144-11152 Regulation denotes affected
T6891 11282-11287 Protein denotes IFN-γ
T6892 11329-11333 Protein denotes IL-4
T6893 11271-11278 Negative_regulation denotes absence
T6894 11320-11328 Localization denotes secreted
T6895 11304-11312 Positive_regulation denotes increase
T6896 11405-11409 Protein denotes IL-4
T6897 11452-11457 Protein denotes IL-10
T6898 11511-11515 Protein denotes CD4+
T6899 11442-11451 Gene_expression denotes producing
T6900 11598-11603 Protein denotes STAT6
T6901 11689-11694 Protein denotes IL-10
T6902 11587-11594 Negative_regulation denotes absence
T6903 11679-11688 Gene_expression denotes producing
T6904 11945-11950 Protein denotes STAT4
T6905 11984-11989 Protein denotes IL-10
T6906 12018-12023 Protein denotes STAT6
T6907 11990-12000 Gene_expression denotes production
T6908 11971-11980 Positive_regulation denotes induction
T6909 11954-11962 Positive_regulation denotes required
T7701 12063-12068 Protein denotes STAT4
T7702 12073-12081 Protein denotes Required
T7703 12544-12549 Protein denotes IL-10
T7704 12554-12559 Protein denotes IFN-γ
T7705 12590-12595 Protein denotes IL-10
T7706 12560-12570 Gene_expression denotes production
T7707 12560-12570 Gene_expression denotes production
T7708 12596-12606 Gene_expression denotes production
T7709 12611-12619 Positive_regulation denotes enhanced
T7710 12536-12543 Positive_regulation denotes induced
T7711 12536-12543 Positive_regulation denotes induced
T7712 12756-12761 Protein denotes STAT4
T7713 12766-12771 Protein denotes STAT6
T7714 12854-12859 Protein denotes STAT4
T7715 12864-12869 Protein denotes STAT6
T7716 12870-12879 Negative_regulation denotes deficient
T7717 13005-13010 Protein denotes IL-10
T7718 13015-13020 Protein denotes IFN-γ
T7719 13089-13094 Protein denotes STAT4
T7720 12986-12996 Gene_expression denotes expression
T7721 12986-12996 Gene_expression denotes expression
T7722 13034-13041 Negative_regulation denotes reduced
T7723 13034-13041 Negative_regulation denotes reduced
T7724 13237-13242 Protein denotes STAT6
T7725 13260-13265 Protein denotes IL-10
T7726 13362-13367 Protein denotes STAT6
T7727 13266-13276 Gene_expression denotes production
T7728 13368-13377 Negative_regulation denotes deficient
T7729 13250-13256 Regulation denotes effect
T9028 13408-13413 Protein denotes IL-10
T9029 13414-13424 Gene_expression denotes Production
T9030 13428-13438 Positive_regulation denotes Maintained
T9031 13522-13525 Protein denotes TCR
T9032 13580-13585 Protein denotes STAT4
T9033 13616-13621 Protein denotes IL-10
T9034 13526-13536 Positive_regulation denotes activation
T9035 13603-13612 Positive_regulation denotes induction
T9036 13646-13650 Protein denotes CD4+
T9037 13757-13762 Protein denotes IL-12
T9038 13813-13818 Protein denotes IL-12
T9039 14051-14056 Protein denotes IL-12
T9040 14139-14142 Protein denotes TCR
T9041 14180-14185 Protein denotes IL-12
T9042 14190-14195 Protein denotes IL-10
T9043 14143-14153 Positive_regulation denotes triggering
T9044 14196-14205 Positive_regulation denotes induction
T9045 14171-14175 Positive_regulation denotes need
T9046 14236-14241 Protein denotes IL-10
T9047 14242-14251 Positive_regulation denotes induction
T9048 14279-14288 Negative_regulation denotes abrogated
T9049 14354-14359 Protein denotes IL-12
T9050 14447-14452 Protein denotes IL-10
T9051 14433-14443 Gene_expression denotes production
T9052 14363-14372 Positive_regulation denotes essential
T9053 14563-14567 Protein denotes CD4+
T9054 14838-14843 Protein denotes IL-10
T9055 14919-14924 Protein denotes IL-10
T9056 15027-15032 Protein denotes IL-12
T9057 15156-15161 Protein denotes IL-10
T9058 14830-14837 Gene_expression denotes produce
T9059 14911-14918 Gene_expression denotes express
T9060 15015-15023 Positive_regulation denotes addition
T9061 15143-15152 Positive_regulation denotes induction
T9062 14801-14808 Positive_regulation denotes induced
T9063 14889-14893 Negative_regulation denotes lost
T9064 15125-15134 Positive_regulation denotes cooperate
T9065 15237-15242 Protein denotes IL-12
T9066 15309-15314 Protein denotes IFN-γ
T9067 15326-15331 Protein denotes IL-10
T9068 15370-15375 Protein denotes IL-10
T9069 15284-15292 Gene_expression denotes produced
T9070 15284-15292 Gene_expression denotes produced
T9071 15362-15369 Gene_expression denotes produce
T9072 15351-15358 Positive_regulation denotes induced
T9073 15492-15497 Protein denotes IL-12
T9074 15543-15548 Protein denotes IL-10
T9075 15549-15559 Gene_expression denotes production
T9076 15530-15539 Positive_regulation denotes induction
T10797 15575-15580 Protein denotes IL-10
T10798 15614-15618 Protein denotes ERK1
T10799 15623-15627 Protein denotes ERK2
T10800 15581-15591 Gene_expression denotes Production
T10801 15628-15638 Positive_regulation denotes Activation
T10802 15628-15638 Positive_regulation denotes Activation
T10803 15679-15684 Protein denotes IL-10
T10804 15818-15823 Protein denotes IL-12
T10805 15685-15694 Positive_regulation denotes induction
T10806 15664-15675 Positive_regulation denotes maintenance
T10807 15708-15716 Positive_regulation denotes required
T10808 15847-15850 Protein denotes TCR
T10809 15895-15899 Protein denotes ERK1
T10810 15904-15908 Protein denotes ERK2
T10811 15977-15981 Protein denotes CD4+
T10812 16071-16075 Protein denotes CD4+
T10813 16192-16196 Protein denotes ERK1
T10814 16201-16205 Protein denotes ERK2
T10815 16364-16368 Protein denotes ERK1
T10816 16373-16377 Protein denotes ERK2
T10817 16408-16413 Protein denotes IL-12
T10818 16206-16216 Positive_regulation denotes activation
T10819 16206-16216 Positive_regulation denotes activation
T10820 16378-16388 Positive_regulation denotes activation
T10821 16378-16388 Positive_regulation denotes activation
T10822 16354-16363 Positive_regulation denotes prolonged
T10823 16354-16363 Positive_regulation denotes prolonged
T10824 16532-16536 Protein denotes ERK1
T10825 16541-16545 Protein denotes ERK2
T10826 16591-16596 Protein denotes IL-10
T10827 16654-16675 Protein denotes blocks downstream ERK
T10828 16546-16556 Positive_regulation denotes activation
T10829 16546-16556 Positive_regulation denotes activation
T10830 16578-16587 Positive_regulation denotes induction
T10831 16676-16686 Positive_regulation denotes activation
T10832 16861-16869 Protein denotes anti-CD3
T10833 16895-16900 Protein denotes IL-12
T10834 16942-16945 Protein denotes TCR
T10835 17028-17033 Protein denotes IL-10
T10836 17038-17043 Protein denotes IFN-γ
T10837 16946-16957 Positive_regulation denotes stimulation
T10838 17013-17022 Gene_expression denotes producing
T10839 17013-17022 Gene_expression denotes producing
T10840 17143-17148 Protein denotes IL-10
T10841 17129-17139 Gene_expression denotes production
T10842 17115-17124 Negative_regulation denotes abrogated
T10843 17214-17218 Protein denotes MEK5
T10844 17243-17247 Protein denotes ERK5
T10845 17264-17268 Protein denotes MEK1
T10846 17274-17278 Protein denotes MEK2
T10847 17303-17307 Protein denotes ERK1
T10848 17312-17316 Protein denotes ERK2
T10849 17412-17416 Protein denotes MEK1
T10850 17421-17425 Protein denotes MEK2
T10851 17484-17488 Protein denotes MEK1
T10852 17493-17497 Protein denotes MEK2
T10853 17506-17510 Protein denotes MEK5
T10854 17229-17239 Positive_regulation denotes activation
T10855 17289-17299 Positive_regulation denotes activation
T10856 17289-17299 Positive_regulation denotes activation
T10857 17426-17435 Negative_regulation denotes inhibitor
T10858 17426-17435 Negative_regulation denotes inhibitor
T10859 17475-17483 Negative_regulation denotes inhibits
T10860 17475-17483 Negative_regulation denotes inhibits
T10861 17475-17483 Negative_regulation denotes inhibits
T10862 17201-17209 Negative_regulation denotes inhibits
T10863 17201-17209 Negative_regulation denotes inhibits
T10864 17201-17209 Negative_regulation denotes inhibits
T10865 17219-17228 Positive_regulation denotes catalyzed
T10866 17591-17596 Protein denotes IL-10
T10867 17597-17607 Gene_expression denotes production
T10868 17577-17587 Negative_regulation denotes inhibition
T10869 17746-17754 Protein denotes p38 MAPK
T10870 17783-17788 Protein denotes GSK3β
T10871 17842-17847 Protein denotes IL-10
T10872 17755-17764 Negative_regulation denotes inhibitor
T10873 17789-17798 Negative_regulation denotes inhibitor
T10874 17848-17858 Gene_expression denotes production
T10875 17832-17838 Regulation denotes effect
T10876 17832-17838 Regulation denotes effect
T10877 17982-17987 Protein denotes IL-12
T10878 17997-18001 Protein denotes ERK1
T10879 18006-18010 Protein denotes ERK2
T10880 18052-18055 Protein denotes p38
T10881 18063-18068 Protein denotes GSK3β
T10882 18034-18044 Positive_regulation denotes activation
T10883 18034-18044 Positive_regulation denotes activation
T11601 18080-18085 Protein denotes IL-10
T11602 18133-18137 Protein denotes ERK1
T11603 18142-18146 Protein denotes ERK2
T11604 18086-18096 Gene_expression denotes Production
T11605 18147-18157 Positive_regulation denotes Activation
T11606 18147-18157 Positive_regulation denotes Activation
T11607 18238-18242 Protein denotes ERK1
T11608 18247-18251 Protein denotes ERK2
T11609 18299-18307 Protein denotes anti-CD3
T11610 18312-18321 Protein denotes anti-CD28
T11611 18451-18454 Protein denotes MEK
T11612 18252-18262 Positive_regulation denotes activation
T11613 18252-18262 Positive_regulation denotes activation
T11614 18455-18464 Negative_regulation denotes inhibitor
T11615 18492-18496 Protein denotes ERK1
T11616 18501-18505 Protein denotes ERK2
T11617 18563-18568 Protein denotes IL-10
T11618 18696-18699 Protein denotes MEK
T11619 18506-18516 Positive_regulation denotes activation
T11620 18506-18516 Positive_regulation denotes activation
T11621 18550-18559 Positive_regulation denotes induction
T11622 18700-18709 Negative_regulation denotes inhibitor
T11623 18537-18545 Positive_regulation denotes required
T11624 18537-18545 Positive_regulation denotes required
T11625 18776-18784 Protein denotes p38 MAPK
T11626 18791-18794 Protein denotes GSK
T11627 18795-18797 Protein denotes 3β
T11628 18842-18847 Protein denotes IL-10
T11629 18798-18808 Positive_regulation denotes activation
T11630 18798-18808 Positive_regulation denotes activation
T11631 18828-18838 Gene_expression denotes expression
T11632 18762-18772 Negative_regulation denotes inhibitors
T11633 18762-18772 Negative_regulation denotes inhibitors
T11634 18817-18823 Regulation denotes affect
T11635 18817-18823 Regulation denotes affect
T11636 18897-18901 Protein denotes ERK1
T11637 18906-18910 Protein denotes ERK2
T11638 18984-18989 Protein denotes IL-10
T11639 18879-18889 Positive_regulation denotes Activation
T11640 18879-18889 Positive_regulation denotes Activation
T11641 18990-19000 Gene_expression denotes production
T11642 18971-18980 Positive_regulation denotes induction
T11643 18951-18962 Positive_regulation denotes requirement
T11644 18951-18962 Positive_regulation denotes requirement
T13430 19438-19441 Protein denotes Il4
T13431 19421-19434 Transcription denotes transcription
T13432 19409-19417 Positive_regulation denotes resulted
T13433 19568-19573 Protein denotes IL-12
T13434 19647-19652 Protein denotes IL-12
T13435 19666-19677 Positive_regulation denotes upregulated
T13436 19740-19744 Protein denotes Il10
T13437 19809-19812 Protein denotes Il4
T13438 19905-19908 Protein denotes Il4
T13439 19745-19758 Transcription denotes transcription
T13440 19813-19823 Gene_expression denotes expression
T13441 19858-19867 Negative_regulation denotes abrogated
T13442 19909-19919 Gene_expression denotes expression
T13443 19858-19867 Negative_regulation denotes abrogated
T13444 19994-20004 Protein denotes IL-10 mRNA
T13445 20005-20015 Gene_expression denotes expression
T13446 19985-19993 Positive_regulation denotes increase
T13447 20114-20118 Protein denotes Il10
T13448 20119-20132 Transcription denotes transcription
T13449 20089-20096 Positive_regulation denotes induced
T13450 20254-20258 Protein denotes CD4+
T13451 20449-20460 Protein denotes GATA-3 mRNA
T13452 20461-20471 Gene_expression denotes expression
T13453 20598-20611 Negative_regulation denotes downregulated
T13454 20751-20756 Protein denotes c-maf
T13455 20737-20747 Gene_expression denotes expression
T13456 20730-20733 Positive_regulation denotes led
T13457 20950-20960 Protein denotes c-Maf mRNA
T13458 20936-20946 Gene_expression denotes expression
T13459 20917-20926 Positive_regulation denotes sustained
T13460 21038-21043 Protein denotes c-maf
T13461 21064-21069 Protein denotes STAT4
T13462 21044-21054 Gene_expression denotes expression
T13463 21070-21080 Positive_regulation denotes activation
T13464 21023-21034 Positive_regulation denotes maintenance
T13465 21055-21063 Positive_regulation denotes required
T13466 21128-21134 Protein denotes IL-17a
T13467 21146-21156 Protein denotes IL-10 mRNA
T13468 21180-21191 Protein denotes GATA-3 mRNA
T13469 21244-21250 Protein denotes ROR-γt
T13470 21118-21127 Gene_expression denotes expressed
T13471 21118-21127 Gene_expression denotes expressed
T13472 21255-21259 Positive_regulation denotes high
T13473 21407-21412 Protein denotes c-Maf
T13474 21426-21435 Gene_expression denotes expressed
T13475 21633-21637 Protein denotes Il10
T13476 21650-21655 Protein denotes c-maf
T13477 21726-21730 Protein denotes MEK1
T13478 21735-21739 Protein denotes MEK2
T13479 21780-21785 Protein denotes RORγt
T13480 21638-21648 Gene_expression denotes expression
T13481 21656-21666 Gene_expression denotes expression
T13482 21740-21749 Negative_regulation denotes inhibitor
T13483 21740-21749 Negative_regulation denotes inhibitor
T13484 21786-21796 Gene_expression denotes expression
T13485 21808-21816 Regulation denotes affected
T18425 21842-21847 Protein denotes IL-10
T18426 21848-21858 Gene_expression denotes expression
T18427 22039-22044 Protein denotes IL-10
T18428 22045-22055 Gene_expression denotes expression
T18429 22184-22189 Protein denotes IL-10
T18430 22197-22205 Gene_expression denotes produced
T18431 22355-22360 Protein denotes IL-10
T18432 22347-22354 Gene_expression denotes produce
T18433 22447-22451 Protein denotes ERK1
T18434 22456-22460 Protein denotes ERK2
T18435 22524-22529 Protein denotes IL-10
T18436 22461-22476 Phosphorylation denotes phosphorylation
T18437 22461-22476 Phosphorylation denotes phosphorylation
T18438 22516-22523 Gene_expression denotes produce
T18439 22412-22420 Positive_regulation denotes required
T18440 22412-22420 Positive_regulation denotes required
T18441 22549-22553 Protein denotes ERK1
T18442 22558-22562 Protein denotes ERK2
T18443 22626-22631 Protein denotes IL-10
T18444 22635-22638 Protein denotes Th1
T18445 22640-22643 Protein denotes Th2
T18446 22723-22728 Protein denotes IL-10
T18447 22563-22573 Positive_regulation denotes activation
T18448 22563-22573 Positive_regulation denotes activation
T18449 22612-22622 Gene_expression denotes production
T18450 22612-22622 Gene_expression denotes production
T18451 22612-22622 Gene_expression denotes production
T18452 22595-22603 Positive_regulation denotes required
T18453 22595-22603 Positive_regulation denotes required
T18454 22595-22603 Positive_regulation denotes required
T18455 22595-22603 Positive_regulation denotes required
T18456 22595-22603 Positive_regulation denotes required
T18457 22595-22603 Positive_regulation denotes required
T18458 23107-23112 Protein denotes IL-10
T18459 23397-23402 Protein denotes IL-10
T18460 23473-23477 Protein denotes CD4+
T18461 23373-23380 Gene_expression denotes express
T18462 23362-23369 Positive_regulation denotes induced
T18463 23702-23707 Protein denotes IL-10
T18464 23721-23726 Protein denotes Foxp3
T18465 23753-23758 Protein denotes IL-10
T18466 23763-23768 Protein denotes IFN-γ
T18467 23879-23884 Protein denotes Foxp3
T18468 23743-23752 Gene_expression denotes coproduce
T18469 23743-23752 Gene_expression denotes coproduce
T18470 23939-23944 Protein denotes IL-10
T18471 24063-24067 Protein denotes CD4+
T18472 24086-24091 Protein denotes IL-10
T18473 23945-23955 Gene_expression denotes production
T18474 24076-24085 Gene_expression denotes producing
T18475 24325-24329 Protein denotes CD4+
T18476 24374-24379 Protein denotes IL-12
T18477 24479-24484 Protein denotes IFN-γ
T18478 24489-24494 Protein denotes IL-10
T18479 24451-24461 Gene_expression denotes expressing
T18480 24451-24461 Gene_expression denotes expressing
T18481 24496-24500 Negative_regulation denotes lose
T18482 24496-24500 Negative_regulation denotes lose
T18483 24635-24639 Protein denotes IL-2
T18484 24672-24677 Protein denotes IL-10
T18485 24627-24631 Negative_regulation denotes loss
T18486 24658-24668 Gene_expression denotes production
T18487 24972-24983 Protein denotes OVA protein
T18488 25031-25036 Protein denotes IL-10
T18489 25100-25105 Protein denotes STAT4
T18490 25018-25027 Positive_regulation denotes induction
T18491 25106-25115 Negative_regulation denotes deficient
T18492 25089-25096 Negative_regulation denotes reduced
T18493 25369-25374 Protein denotes IL-12
T18494 25395-25400 Protein denotes IL-10
T18495 25382-25391 Positive_regulation denotes induction
T18496 25353-25364 Positive_regulation denotes requirement
T18497 25544-25549 Protein denotes IL-10
T18498 25534-25543 Gene_expression denotes producing
T18499 25580-25585 Protein denotes IL-10
T18500 25643-25648 Protein denotes IL-12
T18501 25668-25673 Protein denotes IFN-γ
T18502 25586-25596 Gene_expression denotes production
T18503 25610-25617 Positive_regulation denotes induced
T18504 25653-25664 Negative_regulation denotes independent
T18505 25754-25759 Protein denotes IFN-γ
T18506 25906-25910 Protein denotes CD4+
T18507 25968-25973 Protein denotes IL-10
T18508 26024-26029 Protein denotes IL-10
T18509 26117-26122 Protein denotes IL-12
T18510 25960-25967 Gene_expression denotes express
T18511 26016-26023 Gene_expression denotes produce
T18512 26005-26012 Positive_regulation denotes induced
T18513 26171-26176 Protein denotes IL-12
T18514 26158-26167 Positive_regulation denotes induction
T18515 26141-26150 Positive_regulation denotes dependent
T18516 26290-26295 Protein denotes IL-10
T18517 26346-26350 Protein denotes ERK1
T18518 26355-26359 Protein denotes ERK2
T18519 26296-26306 Gene_expression denotes production
T18520 26336-26342 Gene_expression denotes levels
T18521 26336-26342 Gene_expression denotes levels
T18522 26360-26370 Positive_regulation denotes activation
T18523 26360-26370 Positive_regulation denotes activation
T18524 26360-26370 Positive_regulation denotes activation
T18525 26360-26370 Positive_regulation denotes activation
T18526 26400-26405 Protein denotes IFN-γ
T18527 26526-26529 Protein denotes TCR
T18528 26386-26396 Gene_expression denotes expression
T18529 26530-26540 Positive_regulation denotes activation
T18530 26376-26385 Positive_regulation denotes increased
T18531 26685-26690 Protein denotes IFN-γ
T18532 26701-26706 Protein denotes IL-10
T18533 26741-26746 Protein denotes IL-12
T18534 26777-26782 Protein denotes IL-10
T18535 26694-26700 Positive_regulation denotes induce
T18536 26725-26737 Positive_regulation denotes upregulation
T18537 26769-26776 Positive_regulation denotes induced
T18538 26669-26680 Positive_regulation denotes requirement
T18539 26810-26815 Protein denotes IL-10
T18540 26838-26847 Regulation denotes regulated
T18541 27106-27111 Protein denotes IL-10
T18542 27221-27226 Protein denotes IL-10
T18543 27228-27231 Protein denotes Ito
T18544 27112-27122 Gene_expression denotes production
T18545 27214-27220 Positive_regulation denotes induce
T18546 27214-27220 Positive_regulation denotes induce
T18547 27097-27105 Negative_regulation denotes regulate
T18548 27348-27352 Protein denotes IL-4
T18549 27353-27363 Gene_expression denotes production
T18550 27338-27347 Regulation denotes regulates
T18551 27445-27449 Protein denotes ERK1
T18552 27454-27458 Protein denotes ERK2
T18553 27492-27497 Protein denotes IL-10
T18554 27512-27515 Protein denotes Th1
T18555 27517-27520 Protein denotes Th2
T18556 27459-27469 Positive_regulation denotes activation
T18557 27459-27469 Positive_regulation denotes activation
T18558 27498-27508 Gene_expression denotes production
T18559 27478-27488 Regulation denotes regulation
T18560 27666-27671 Protein denotes IL-10
T18561 27730-27738 Gene_expression denotes produced
T18562 27752-27761 Regulation denotes regulated
T18563 27827-27831 Protein denotes ERK1
T18564 27836-27840 Protein denotes ERK2
T18565 27872-27877 Protein denotes IL-10
T18566 27841-27851 Positive_regulation denotes activation
T18567 27841-27851 Positive_regulation denotes activation
T18568 27878-27888 Gene_expression denotes production
T18569 27859-27868 Positive_regulation denotes induction
T18570 28027-28032 Protein denotes IL-10
T18571 28036-28039 Protein denotes Th1
T18572 28128-28135 Protein denotes histone
T18573 28155-28165 Protein denotes IL-10 gene
T18574 28013-28023 Regulation denotes regulation
T18575 28136-28147 Positive_regulation denotes acetylation
T18576 28136-28147 Positive_regulation denotes acetylation
T18577 28275-28280 Protein denotes IL-10
T18578 28396-28401 Protein denotes IFN-γ
T18579 28486-28491 Protein denotes IL-12
T18580 28519-28524 Protein denotes IL-10
T18581 28529-28534 Protein denotes IFN-γ
T18582 28284-28292 Gene_expression denotes produced
T18583 28402-28412 Gene_expression denotes production
T18584 28535-28545 Gene_expression denotes expression
T18585 28535-28545 Gene_expression denotes expression
T18586 28506-28514 Positive_regulation denotes required
T18587 28506-28514 Positive_regulation denotes required
T18588 28590-28595 Protein denotes IL-10
T18589 28625-28630 Protein denotes IL-12
T18590 28634-28638 Protein denotes IL-4
T18591 28650-28660 Protein denotes IL-10 gene
T18592 28677-28683 Protein denotes GATA-3
T18593 28728-28739 Protein denotes IL-10 locus
T18594 28780-28785 Protein denotes IL-10
T18595 28596-28606 Gene_expression denotes expression
T18596 28664-28673 Gene_expression denotes imprinted
T18597 28664-28673 Gene_expression denotes imprinted
T18598 28786-28794 Gene_expression denotes produced
T18599 28575-28586 Positive_regulation denotes maintenance
T18600 28894-28899 Protein denotes IL-12
T18601 29002-29007 Protein denotes IL-10
T18602 29008-29018 Gene_expression denotes expression
T18603 28995-29001 Positive_regulation denotes induce
T18604 29067-29072 Protein denotes c-maf
T18605 29053-29063 Gene_expression denotes Expression
T18606 29085-29095 Negative_regulation denotes diminished
T18607 29154-29164 Positive_regulation denotes maintained
T18608 29287-29292 Protein denotes IL-10
T18609 29310-29313 Protein denotes ERK
T18610 29389-29394 Protein denotes c-Maf
T18611 29454-29459 Protein denotes IL-10
T18612 29314-29324 Positive_regulation denotes activation
T18613 29460-29470 Gene_expression denotes expression
T18614 29297-29306 Positive_regulation denotes dependent
T18615 29554-29563 Protein denotes Th17 CD4+
T18616 29680-29685 Protein denotes IL-10
T18617 29664-29671 Positive_regulation denotes induced
T18618 29687-29691 Protein denotes ERK1
T18619 29696-29700 Protein denotes ERK2
T18620 29701-29711 Positive_regulation denotes activation
T18621 29701-29711 Positive_regulation denotes activation
T18622 29808-29813 Protein denotes IL-10
T18623 29865-29870 Protein denotes IL-10
T18624 29955-29960 Protein denotes IL-12
T18625 29794-29804 Gene_expression denotes expression
T18626 29871-29881 Gene_expression denotes expression
T18627 29885-29892 Positive_regulation denotes induced
T18628 29902-29911 Positive_regulation denotes amplified
T18629 29916-29925 Regulation denotes regulated
T18630 30156-30161 Protein denotes IL-10
T18631 30142-30152 Gene_expression denotes production
T18632 30129-30137 Regulation denotes regulate
T18633 30364-30369 Protein denotes IL-10
T18634 30370-30380 Gene_expression denotes production
T18635 30350-30360 Regulation denotes regulation
T19041 30663-30669 Protein denotes TCR WT
T19042 30691-30695 Protein denotes Rag1
T19043 30705-30710 Protein denotes IFN-γ
T19044 30713-30718 Protein denotes STAT4
T19045 30725-30730 Protein denotes STAT6
T19046 30731-30740 Negative_regulation denotes deficient
T19047 30731-30740 Negative_regulation denotes deficient
T19048 31469-31494 Protein denotes chicken ovalbumin protein
T19049 31496-31507 Protein denotes OVA protein
T19050 31542-31562 Protein denotes ovalbumin peptide323
T19051 31650-31658 Protein denotes PD184352
T19052 31660-31663 Protein denotes MEK
T19053 31677-31685 Protein denotes SB203580
T19054 31687-31690 Protein denotes p38
T19055 31707-31714 Protein denotes CT99021
T19056 31716-31721 Protein denotes GSK3β
T19057 31664-31674 Negative_regulation denotes inhibitors
T19058 31664-31674 Negative_regulation denotes inhibitors
T19059 31691-31700 Negative_regulation denotes inhibitor
T19060 31691-31700 Negative_regulation denotes inhibitor
T19061 31722-31731 Negative_regulation denotes inhibitor
T19062 31722-31731 Negative_regulation denotes inhibitor
T19893 31818-31822 Protein denotes CD4+
T19894 31838-31848 Protein denotes Splenic DC
T19895 31805-31814 Localization denotes Isolation
T19896 31927-31930 Protein denotes CD4
T19897 31931-31938 Protein denotes CD62Lhi
T19898 31940-31943 Protein denotes CD4
T19899 31944-31955 Protein denotes CD62LhiCD25
T19900 31961-31964 Protein denotes CD4
T19901 31965-31975 Protein denotes CD44loCD25
T19902 32148-32152 Protein denotes CD4+
T19903 32282-32288 Protein denotes CD11c+
T19904 32555-32560 Protein denotes IL-12
T19905 32603-32607 Protein denotes CD4+
T19906 32661-32669 Protein denotes anti-CD3
T19907 32674-32683 Protein denotes anti-CD28
T19908 32929-32932 Protein denotes Th1
T19909 33166-33174 Protein denotes PD184352
T19910 33176-33179 Protein denotes MEK
T19911 33193-33201 Protein denotes SB203580
T19912 33203-33206 Protein denotes p38
T19913 33219-33226 Protein denotes CT99021
T19914 33228-33233 Protein denotes GSK3β
T19915 33180-33190 Negative_regulation denotes inhibitors
T19916 33207-33216 Negative_regulation denotes inhibitor
T19917 33207-33216 Negative_regulation denotes inhibitor
T19918 33234-33243 Negative_regulation denotes inhibitor
T19919 33234-33243 Negative_regulation denotes inhibitor
T19920 33279-33286 Gene_expression denotes present
T19921 33279-33286 Gene_expression denotes present
T19922 33279-33286 Gene_expression denotes present
T19923 33378-33380 Protein denotes S7
T20210 33842-33846 Protein denotes IL-4
T20211 33848-33853 Protein denotes IL-10
T20212 33859-33864 Protein denotes IFN-γ
T20605 34081-34091 Protein denotes DO11.10 WT
T20606 34095-34099 Protein denotes STAT
T20607 34100-34109 Negative_regulation denotes deficient
T20608 34100-34109 Negative_regulation denotes deficient
T20609 34464-34474 Protein denotes BrefeldinA
T20610 34584-34587 Protein denotes CD4
T20611 34588-34593 Protein denotes PerCP
T20612 34610-34615 Protein denotes IFN-γ
T20613 34620-34625 Protein denotes IL-10
T20857 35193-35202 Protein denotes ubiquitin
T20858 35206-35215 Protein denotes HPRT mRNA
T20999 35269-35273 Protein denotes CD4+
T21000 35496-35499 Protein denotes ERK
T21001 35504-35509 Protein denotes actin
R545 T771 T774 themeOf ERK MAP Kinase,Activation
R546 T772 T773 partOf High Antigen,Dose
R547 T773 T774 Site Dose,Activation
R548 T774 T775 themeOf Activation,Interleukin-12-Induced
R549 T777 T781 themeOf interleukin-10,producing
R550 T778 T782 themeOf IL-10,producing
R551 T779 T783 themeOf interferon-γ,producing
R552 T780 T784 themeOf IFN-γ,producing
R553 T785 T790 themeOf T cell receptor,ligation
R554 T786 T791 themeOf TCR,ligation
R555 T787 T792 themeOf ERK1,phosphorylation
R556 T788 T793 themeOf ERK2 MAP kinases,phosphorylation
R557 T789 T794 themeOf STAT4,activation
R558 T790 T795 causeOf ligation,required
R559 T790 T796 causeOf ligation,required
R560 T790 T799 causeOf ligation,required
R561 T791 T797 causeOf ligation,required
R562 T791 T798 causeOf ligation,required
R563 T791 T800 causeOf ligation,required
R564 T792 T795 themeOf phosphorylation,required
R565 T792 T797 themeOf phosphorylation,required
R566 T793 T796 themeOf phosphorylation,required
R567 T793 T798 themeOf phosphorylation,required
R568 T794 T799 themeOf activation,required
R569 T794 T800 themeOf activation,required
R570 T794 T801 themeOf activation,IL-12-induced
R571 T801 T802 themeOf IL-12-induced,activation
R572 T803 T806 themeOf TCR,triggering
R573 T804 T807 themeOf IL-10,production
R574 T807 T808 themeOf production,enhanced
R575 T809 T813 themeOf STATs,activation
R576 T810 T814 themeOf ERK1,activation
R577 T811 T815 themeOf ERK2,activation
R578 T812 T816 themeOf IL-10,production
R579 T813 T817 themeOf activation,require
R580 T814 T818 causeOf activation,requirement
R581 T815 T819 causeOf activation,requirement
R582 T816 T818 themeOf production,requirement
R583 T816 T819 themeOf production,requirement
R584 T820 T822 themeOf IL-10,expression
R585 T821 T823 themeOf c-maf,expression
R586 T824 T825 themeOf IL-10,production
R1931 T2555 T2556 themeOf IL-10,expressed
R1934 T2560 T2566 themeOf interferon-γ,produce
R1935 T2561 T2567 themeOf IFN-γ,produce
R1937 T2562 T2568 themeOf IL-10,produce
R1940 T2569 T2571 themeOf IFN-γ,coproducing
R1941 T2570 T2572 themeOf IL-10,coproducing
R1943 T2573 T2574 themeOf IL-10,production
R1944 T2575 T2577 themeOf IL-10,produced
R1945 T2576 T2578 themeOf IFN-γ,produced
R1949 T2582 T2586 causeOf IL-18,induced
R1950 T2583 T2586 themeOf IRAK,induced
R1955 T2587 T2593 themeOf IL-4,expression
R1956 T2588 T2594 themeOf IL-5,expression
R1957 T2589 T2595 causeOf IL-4,requires
R1958 T2589 T2596 causeOf IL-4,requires
R1960 T2590 T2595 themeOf STAT6,requires
R1961 T2592 T2596 themeOf GATA,requires
R1964 T2597 T2600 themeOf IL-6,expression
R1965 T2599 T2601 causeOf STAT3,dependent
R1967 T2600 T2601 themeOf expression,dependent
R1968 T2602 T2613 themeOf TCR,phosphorylation
R1970 T2603 T2610 themeOf ERK,regulated
R1971 T2603 T2614 themeOf ERK,phosphorylation
R1972 T2604 T2611 themeOf mitogen-activated protein kinase,regulated
R1973 T2604 T2615 themeOf mitogen-activated protein kinase,phosphorylation
R1974 T2605 T2612 themeOf MAPK,regulated
R1975 T2605 T2616 themeOf MAPK,phosphorylation
R1977 T2606 T2621 themeOf IFN-γ,producing
R1979 T2607 T2622 themeOf ERK1,producing
R1980 T2608 T2623 themeOf ERK2,activation
R1982 T2609 T2626 themeOf IL-4,secretion
R1983 T2613 T2617 themeOf phosphorylation,result
R1984 T2613 T2627 themeOf phosphorylation,regulated
R1985 T2614 T2618 themeOf phosphorylation,result
R1986 T2614 T2628 themeOf phosphorylation,regulated
R1987 T2615 T2619 themeOf phosphorylation,result
R1988 T2615 T2629 themeOf phosphorylation,regulated
R1989 T2616 T2620 themeOf phosphorylation,result
R1990 T2616 T2630 themeOf phosphorylation,regulated
R1991 T2621 T2624 themeOf producing,activation
R1992 T2621 T2631 themeOf producing,result
R1993 T2622 T2625 themeOf producing,activation
R1994 T2622 T2632 themeOf producing,result
R1995 T2633 T2634 themeOf IL-10,produced
R1996 T2638 T2640 themeOf ERK1,phosphorylation
R1997 T2639 T2641 themeOf ERK2,phosphorylation
R1998 T2640 T2642 themeOf phosphorylation,activation
R1999 T2641 T2643 themeOf phosphorylation,activation
R2000 T2644 T2649 themeOf ERK1,activation
R2001 T2645 T2650 themeOf ERK2,activation
R2002 T2646 T2651 themeOf IL-10,production
R2003 T2647 T2652 themeOf Th1,production
R2004 T2648 T2653 themeOf Th2,production
R2005 T2649 T2654 causeOf activation,requirement
R2006 T2649 T2655 causeOf activation,requirement
R2007 T2649 T2656 causeOf activation,requirement
R2008 T2650 T2657 causeOf activation,requirement
R2009 T2650 T2658 causeOf activation,requirement
R2010 T2650 T2659 causeOf activation,requirement
R2011 T2651 T2654 themeOf production,requirement
R2012 T2651 T2657 themeOf production,requirement
R2013 T2652 T2655 themeOf production,requirement
R2014 T2652 T2658 themeOf production,requirement
R2015 T2653 T2656 themeOf production,requirement
R2016 T2653 T2659 themeOf production,requirement
R2017 T2660 T2661 themeOf IL-10,induction
R3467 T4552 T4556 themeOf IFN-γ,coproducing
R3470 T4553 T4557 themeOf IL-10,coproducing
R3473 T4558 T4560 themeOf Th1,expressing
R3475 T4559 T4561 themeOf IFN-γ,expressing
R3477 T4562 T4564 themeOf IL-4,expressed
R3478 T4563 T4565 themeOf IL-10,expressed
R3481 T4568 T4572 themeOf anti-CD28 antibodies,stimulation
R3482 T4569 T4572 causeOf IL-12,stimulation
R3484 T4570 T4573 themeOf IFN-γ,producing
R3485 T4571 T4574 themeOf IL-10,coproduced
R3487 T4575 T4579 themeOf IL-10,lack
R3488 T4575 T4580 themeOf IL-10,produced
R3489 T4576 T4582 themeOf IL-10,production
R3491 T4579 T4581 themeOf lack,resulted
R3492 T4580 T4583 themeOf produced,lack
R3494 T4582 T4584 themeOf production,inhibition
R3495 T4585 T4588 themeOf IFN-γ,expression
R3496 T4586 T4589 themeOf IL-10,expression
R3498 T4587 T4590 themeOf IL-10,production
R3499 T4588 T4591 themeOf expression,induced
R3500 T4589 T4592 themeOf expression,induced
R3502 T4590 T4593 themeOf production,induce
R3504 T4595 T4596 themeOf IL-10 protein,produced
R3505 T4597 T4599 themeOf IL-10,producing
R3507 T4598 T4600 causeOf IL-12,required
R3508 T4599 T4600 themeOf producing,required
R3510 T4601 T4603 themeOf IL-10,produce
R3511 T4602 T4604 themeOf IFN-γ,produce
R3514 T4608 T4612 themeOf gene 1,-deficient
R3515 T4609 T4613 themeOf Rag1,-deficient
R3516 T4611 T4614 themeOf IL-10,expression
R3518 T4614 T4615 themeOf expression,resulted
R3520 T4616 T4619 causeOf TGF-β,induce
R3521 T4617 T4619 themeOf IL-10,induce
R3522 T4623 T4624 themeOf production,increased
R3523 T4620 T4622 themeOf TGF-β,neutralization
R3524 T4621 T4623 themeOf IL-10,production
R5174 T6803 T6808 themeOf IL-10,Production
R5180 T6808 T6809 themeOf Production,Dependent
R5185 T6810 T6812 themeOf IL-10,producing
R5187 T6811 T6813 themeOf STAT4,role
R5190 T6811 T6814 themeOf STAT4,activated
R5192 T6815 T6817 themeOf STAT4,deficient
R5197 T6818 T6823 themeOf STAT4,absence
R5198 T6819 T6824 themeOf IFN-γ,expressing
R5199 T6820 T6826 themeOf IL-4,expressing
R5200 T6821 T6829 causeOf STAT4,contributes
R5201 T6822 T6827 themeOf IL-10,expression
R5202 T6823 T6825 causeOf absence,diminished
R5203 T6824 T6825 themeOf expressing,diminished
R5204 T6826 T6828 themeOf expressing,increase
R5205 T6830 T6833 themeOf IL-10,expression
R5206 T6832 T6834 themeOf STAT6,activation
R5207 T6827 T6829 themeOf expression,contributes
R5208 T6835 T6837 themeOf STAT6,absence
R5209 T6838 T6841 themeOf STAT6,deficient
R5210 T6897 T6899 themeOf IL-10,producing
R5211 T6839 T6842 themeOf IL-10,produced
R5212 T6840 T6843 themeOf IFN-γ,produced
R5213 T6900 T6902 themeOf STAT6,absence
R5214 T6844 T6848 themeOf STAT6,lack
R5215 T6845 T6849 themeOf IL-4,production
R5216 T6846 T6850 themeOf IL-10,production
R5217 T6901 T6903 themeOf IL-10,producing
R5218 T6848 T6851 causeOf lack,abrogated
R5219 T6848 T6852 causeOf lack,abrogated
R5220 T6849 T6851 themeOf production,abrogated
R5221 T6850 T6852 themeOf production,abrogated
R5222 T6904 T6909 causeOf STAT4,required
R5223 T6854 T6856 themeOf IL-10,production
R5224 T6855 T6857 themeOf IL-4,production
R5225 T6856 T6858 themeOf production,increased
R5226 T6905 T6907 themeOf IL-10,production
R5227 T6857 T6859 themeOf production,increased
R5228 T6906 T6908 causeOf STAT6,induction
R5229 T6860 T6863 themeOf IL-10,expression
R5230 T6907 T6908 themeOf production,induction
R5231 T6908 T6909 themeOf induction,required
R5232 T6863 T6864 themeOf expression,depended
R5233 T6865 T6870 themeOf STAT4,deficient
R5234 T6866 T6871 themeOf IL-10,produce
R5235 T6867 T6872 themeOf IFN-γ,absence
R5236 T6868 T6873 themeOf DO11.10 IFN-γ,deficient
R5237 T6871 T6874 themeOf produce,inability
R5238 T6875 T6881 themeOf IL-10,secretion
R5239 T6875 T6883 themeOf IL-10,induced
R5240 T6876 T6882 themeOf IL-12,secretion
R5241 T6877 T6886 themeOf IFN-γ,absence
R5242 T6878 T6887 themeOf IL-10,expression
R5243 T6880 T6888 causeOf IFN-γ,independent
R5244 T6881 T6884 themeOf secretion,induced
R5245 T6881 T6889 themeOf secretion,affected
R5246 T6882 T6885 themeOf secretion,induced
R5247 T6882 T6890 themeOf secretion,affected
R5248 T6886 T6889 causeOf absence,affected
R5249 T6886 T6890 causeOf absence,affected
R5250 T6887 T6888 themeOf expression,independent
R5251 T6891 T6893 themeOf IFN-γ,absence
R5252 T6892 T6894 themeOf IL-4,secreted
R5253 T6893 T6895 causeOf absence,increase
R5254 T6894 T6895 themeOf secreted,increase
R5880 T7703 T7706 themeOf IL-10,production
R5881 T7704 T7707 themeOf IFN-γ,production
R5882 T7705 T7708 themeOf IL-10,production
R5883 T7706 T7710 themeOf production,induced
R5884 T7707 T7711 themeOf production,induced
R5885 T7708 T7709 themeOf production,enhanced
R5886 T7715 T7716 themeOf STAT6,deficient
R5887 T7717 T7720 themeOf IL-10,expression
R5888 T7718 T7721 themeOf IFN-γ,expression
R5889 T7720 T7722 themeOf expression,reduced
R5890 T7721 T7723 themeOf expression,reduced
R5891 T7725 T7727 themeOf IL-10,production
R5892 T7726 T7728 themeOf STAT6,deficient
R5893 T7727 T7729 themeOf production,effect
R6912 T9028 T9029 themeOf IL-10,Production
R6913 T9029 T9030 themeOf Production,Maintained
R6914 T9031 T9034 themeOf TCR,activation
R6915 T9033 T9035 themeOf IL-10,induction
R6916 T9040 T9043 themeOf TCR,triggering
R6917 T9041 T9045 causeOf IL-12,need
R6918 T9042 T9044 themeOf IL-10,induction
R6919 T9044 T9045 themeOf induction,need
R6920 T9046 T9047 themeOf IL-10,induction
R6921 T9047 T9048 themeOf induction,abrogated
R6922 T9049 T9052 causeOf IL-12,essential
R6923 T9050 T9051 themeOf IL-10,production
R6924 T9051 T9052 themeOf production,essential
R6925 T9054 T9058 themeOf IL-10,produce
R6926 T9055 T9059 themeOf IL-10,express
R6927 T9056 T9060 themeOf IL-12,addition
R6928 T9057 T9061 themeOf IL-10,induction
R6929 T9058 T9062 themeOf produce,induced
R6930 T9059 T9063 themeOf express,lost
R6931 T9061 T9064 themeOf induction,cooperate
R6932 T9066 T9069 themeOf IFN-γ,produced
R6933 T9067 T9070 themeOf IL-10,produced
R6934 T9068 T9071 themeOf IL-10,produce
R6935 T9071 T9072 themeOf produce,induced
R6936 T9074 T9075 themeOf IL-10,production
R6937 T9075 T9076 themeOf production,induction
R8337 T10797 T10800 themeOf IL-10,Production
R8338 T10798 T10801 themeOf ERK1,Activation
R8339 T10799 T10802 themeOf ERK2,Activation
R8340 T10803 T10805 themeOf IL-10,induction
R8341 T10805 T10806 themeOf induction,maintenance
R8342 T10806 T10807 themeOf maintenance,required
R8343 T10813 T10818 themeOf ERK1,activation
R8344 T10814 T10819 themeOf ERK2,activation
R8345 T10815 T10820 themeOf ERK1,activation
R8346 T10816 T10821 themeOf ERK2,activation
R8347 T10820 T10822 themeOf activation,prolonged
R8348 T10821 T10823 themeOf activation,prolonged
R8349 T10824 T10828 themeOf ERK1,activation
R8350 T10825 T10829 themeOf ERK2,activation
R8351 T10826 T10830 themeOf IL-10,induction
R8352 T10827 T10831 themeOf blocks downstream ERK,activation
R8353 T10834 T10837 themeOf TCR,stimulation
R8354 T10835 T10838 themeOf IL-10,producing
R8355 T10836 T10839 themeOf IFN-γ,producing
R8356 T10840 T10841 themeOf IL-10,production
R8357 T10841 T10842 themeOf production,abrogated
R8358 T10843 T10865 causeOf MEK5,catalyzed
R8359 T10844 T10854 themeOf ERK5,activation
R8360 T10847 T10855 themeOf ERK1,activation
R8361 T10848 T10856 themeOf ERK2,activation
R8362 T10849 T10857 themeOf MEK1,inhibitor
R8363 T10850 T10858 themeOf MEK2,inhibitor
R8364 T10851 T10859 themeOf MEK1,inhibits
R8365 T10852 T10860 themeOf MEK2,inhibits
R8366 T10853 T10861 themeOf MEK5,inhibits
R8367 T10854 T10862 themeOf activation,inhibits
R8368 T10854 T10865 themeOf activation,catalyzed
R8369 T10855 T10863 themeOf activation,inhibits
R8370 T10856 T10864 themeOf activation,inhibits
R8371 T10866 T10867 themeOf IL-10,production
R8372 T10867 T10868 themeOf production,inhibition
R8373 T10869 T10872 themeOf p38 MAPK,inhibitor
R8374 T10870 T10873 themeOf GSK3β,inhibitor
R8375 T10871 T10874 themeOf IL-10,production
R8376 T10872 T10875 causeOf inhibitor,effect
R8377 T10873 T10876 causeOf inhibitor,effect
R8378 T10874 T10875 themeOf production,effect
R8379 T10874 T10876 themeOf production,effect
R8380 T10880 T10882 themeOf p38,activation
R8381 T10881 T10883 themeOf GSK3β,activation
R8962 T11601 T11604 themeOf IL-10,Production
R8963 T11602 T11605 themeOf ERK1,Activation
R8964 T11603 T11606 themeOf ERK2,Activation
R8965 T11607 T11612 themeOf ERK1,activation
R8966 T11608 T11613 themeOf ERK2,activation
R8967 T11611 T11614 themeOf MEK,inhibitor
R8968 T11615 T11619 themeOf ERK1,activation
R8969 T11616 T11620 themeOf ERK2,activation
R8970 T11617 T11621 themeOf IL-10,induction
R8971 T11618 T11622 themeOf MEK,inhibitor
R8972 T11619 T11623 causeOf activation,required
R8973 T11620 T11624 causeOf activation,required
R8974 T11621 T11623 themeOf induction,required
R8975 T11621 T11624 themeOf induction,required
R8976 T11626 T11629 themeOf GSK,activation
R8977 T11627 T11630 themeOf 3β,activation
R8978 T11628 T11631 themeOf IL-10,expression
R8979 T11629 T11632 themeOf activation,inhibitors
R8980 T11630 T11633 themeOf activation,inhibitors
R8981 T11631 T11634 themeOf expression,affect
R8982 T11631 T11635 themeOf expression,affect
R8983 T11632 T11634 causeOf inhibitors,affect
R8984 T11633 T11635 causeOf inhibitors,affect
R8985 T11636 T11639 themeOf ERK1,Activation
R8986 T11637 T11640 themeOf ERK2,Activation
R8987 T11638 T11641 themeOf IL-10,production
R8988 T11639 T11643 causeOf Activation,requirement
R8989 T11640 T11644 causeOf Activation,requirement
R8990 T11641 T11642 themeOf production,induction
R8991 T11642 T11643 themeOf induction,requirement
R8992 T11642 T11644 themeOf induction,requirement
R10500 T13430 T13431 themeOf Il4,transcription
R10501 T13431 T13432 themeOf transcription,resulted
R10502 T13434 T13435 themeOf IL-12,upregulated
R10503 T13436 T13439 themeOf Il10,transcription
R10504 T13437 T13440 themeOf Il4,expression
R10505 T13438 T13442 themeOf Il4,expression
R10506 T13439 T13441 themeOf transcription,abrogated
R10507 T13442 T13443 themeOf expression,abrogated
R10508 T13444 T13445 themeOf IL-10 mRNA,expression
R10509 T13445 T13446 themeOf expression,increase
R10510 T13447 T13448 themeOf Il10,transcription
R10511 T13448 T13449 themeOf transcription,induced
R10512 T13451 T13452 themeOf GATA-3 mRNA,expression
R10513 T13452 T13453 themeOf expression,downregulated
R10514 T13454 T13455 themeOf c-maf,expression
R10515 T13455 T13456 themeOf expression,led
R10516 T13457 T13458 themeOf c-Maf mRNA,expression
R10517 T13458 T13459 themeOf expression,sustained
R10518 T13460 T13462 themeOf c-maf,expression
R10519 T13461 T13463 themeOf STAT4,activation
R10520 T13462 T13464 themeOf expression,maintenance
R10521 T13463 T13465 themeOf activation,required
R10522 T13464 T13465 causeOf maintenance,required
R10523 T13466 T13470 themeOf IL-17a,expressed
R10524 T13467 T13471 themeOf IL-10 mRNA,expressed
R10525 T13468 T13472 causeOf GATA-3 mRNA,high
R10526 T13469 T13472 themeOf ROR-γt,high
R10527 T13473 T13474 themeOf c-Maf,expressed
R10528 T13475 T13480 themeOf Il10,expression
R10529 T13476 T13481 themeOf c-maf,expression
R10530 T13477 T13482 themeOf MEK1,inhibitor
R10531 T13478 T13483 themeOf MEK2,inhibitor
R10532 T13479 T13484 themeOf RORγt,expression
R10533 T13484 T13485 themeOf expression,affected
R14625 T18425 T18426 themeOf IL-10,expression
R14628 T18427 T18428 themeOf IL-10,expression
R14629 T18429 T18430 themeOf IL-10,produced
R14631 T18431 T18432 themeOf IL-10,produce
R14633 T18433 T18436 themeOf ERK1,phosphorylation
R14635 T18434 T18437 themeOf ERK2,phosphorylation
R14636 T18435 T18438 themeOf IL-10,produce
R14637 T18436 T18439 themeOf phosphorylation,required
R14639 T18437 T18440 themeOf phosphorylation,required
R14640 T18441 T18447 themeOf ERK1,activation
R14641 T18442 T18448 themeOf ERK2,activation
R14643 T18443 T18449 themeOf IL-10,production
R14644 T18444 T18450 themeOf Th1,production
R14645 T18445 T18451 themeOf Th2,production
R14646 T18447 T18452 causeOf activation,required
R14647 T18447 T18453 causeOf activation,required
R14648 T18447 T18454 causeOf activation,required
R14649 T18448 T18455 causeOf activation,required
R14650 T18448 T18456 causeOf activation,required
R14651 T18448 T18457 causeOf activation,required
R14652 T18449 T18452 themeOf production,required
R14653 T18449 T18455 themeOf production,required
R14655 T18450 T18453 themeOf production,required
R14656 T18450 T18456 themeOf production,required
R14657 T18451 T18454 themeOf production,required
R14658 T18451 T18457 themeOf production,required
R14661 T18459 T18461 themeOf IL-10,express
R14663 T18461 T18462 themeOf express,induced
R14665 T18465 T18468 themeOf IL-10,coproduce
R14666 T18466 T18469 themeOf IFN-γ,coproduce
R14669 T18470 T18473 themeOf IL-10,production
R14671 T18472 T18474 themeOf IL-10,producing
R14673 T18477 T18479 themeOf IFN-γ,expressing
R14675 T18478 T18480 themeOf IL-10,expressing
R14676 T18479 T18481 themeOf expressing,lose
R14678 T18480 T18482 themeOf expressing,lose
R14680 T18483 T18485 themeOf IL-2,loss
R14681 T18484 T18486 themeOf IL-10,production
R14683 T18488 T18490 themeOf IL-10,induction
R14685 T18489 T18491 themeOf STAT4,deficient
R14686 T18490 T18492 themeOf induction,reduced
R14687 T18491 T18492 causeOf deficient,reduced
R14688 T18493 T18496 causeOf IL-12,requirement
R14689 T18494 T18495 themeOf IL-10,induction
R14691 T18495 T18496 themeOf induction,requirement
R14692 T18497 T18498 themeOf IL-10,producing
R14693 T18499 T18502 themeOf IL-10,production
R14694 T18500 T18503 causeOf IL-12,induced
R14696 T18501 T18504 causeOf IFN-γ,independent
R14698 T18502 T18503 themeOf production,induced
R14699 T18502 T18504 themeOf production,independent
R14701 T18507 T18510 themeOf IL-10,express
R14703 T18508 T18511 themeOf IL-10,produce
R14705 T18511 T18512 themeOf produce,induced
R14706 T18513 T18514 themeOf IL-12,induction
R14707 T18514 T18515 themeOf induction,dependent
R14709 T18516 T18519 themeOf IL-10,production
R14710 T18517 T18520 themeOf ERK1,levels
R14711 T18517 T18522 themeOf ERK1,activation
R14713 T18518 T18521 themeOf ERK2,levels
R14714 T18518 T18523 themeOf ERK2,activation
R14717 T18520 T18524 themeOf levels,activation
R14719 T18521 T18525 themeOf levels,activation
R14720 T18609 T18612 themeOf ERK,activation
R14721 T18526 T18528 themeOf IFN-γ,expression
R14722 T18527 T18529 themeOf TCR,activation
R14723 T18528 T18530 themeOf expression,increased
R14724 T18611 T18613 themeOf IL-10,expression
R14725 T18531 T18538 causeOf IFN-γ,requirement
R14726 T18532 T18535 themeOf IL-10,induce
R14727 T18533 T18536 themeOf IL-12,upregulation
R14728 T18612 T18614 themeOf activation,dependent
R14729 T18534 T18537 themeOf IL-10,induced
R14730 T18535 T18538 themeOf induce,requirement
R14731 T18616 T18617 themeOf IL-10,induced
R14732 T18539 T18540 themeOf IL-10,regulated
R14733 T18541 T18544 themeOf IL-10,production
R14734 T18542 T18545 themeOf IL-10,induce
R14735 T18543 T18546 themeOf Ito,induce
R14736 T18618 T18620 themeOf ERK1,activation
R14737 T18544 T18547 themeOf production,regulate
R14738 T18619 T18621 themeOf ERK2,activation
R14739 T18548 T18549 themeOf IL-4,production
R14740 T18549 T18550 themeOf production,regulates
R14741 T18622 T18625 themeOf IL-10,expression
R14742 T18551 T18556 themeOf ERK1,activation
R14743 T18552 T18557 themeOf ERK2,activation
R14744 T18553 T18558 themeOf IL-10,production
R14745 T18623 T18626 themeOf IL-10,expression
R14746 T18558 T18559 themeOf production,regulation
R14747 T18624 T18628 causeOf IL-12,amplified
R14748 T18560 T18561 themeOf IL-10,produced
R14749 T18561 T18562 themeOf produced,regulated
R14750 T18624 T18629 causeOf IL-12,regulated
R14751 T18563 T18566 themeOf ERK1,activation
R14752 T18626 T18627 themeOf expression,induced
R14753 T18564 T18567 themeOf ERK2,activation
R14754 T18565 T18568 themeOf IL-10,production
R14755 T18626 T18628 themeOf expression,amplified
R14756 T18568 T18569 themeOf production,induction
R14757 T18626 T18629 themeOf expression,regulated
R14758 T18630 T18631 themeOf IL-10,production
R14759 T18570 T18574 themeOf IL-10,regulation
R14760 T18572 T18575 themeOf histone,acetylation
R14761 T18573 T18576 themeOf IL-10 gene,acetylation
R14762 T18631 T18632 themeOf production,regulate
R14763 T18577 T18582 themeOf IL-10,produced
R14764 T18578 T18583 themeOf IFN-γ,production
R14765 T18633 T18634 themeOf IL-10,production
R14766 T18580 T18584 themeOf IL-10,expression
R14767 T18581 T18585 themeOf IFN-γ,expression
R14768 T18634 T18635 themeOf production,regulation
R14769 T18584 T18586 themeOf expression,required
R14770 T18585 T18587 themeOf expression,required
R14771 T18588 T18595 themeOf IL-10,expression
R14772 T18591 T18596 themeOf IL-10 gene,imprinted
R14773 T18592 T18597 themeOf GATA-3,imprinted
R14774 T18594 T18598 themeOf IL-10,produced
R14775 T18595 T18599 themeOf expression,maintenance
R14776 T18601 T18602 themeOf IL-10,expression
R14777 T18602 T18603 themeOf expression,induce
R14778 T18604 T18605 themeOf c-maf,Expression
R14779 T18605 T18606 themeOf Expression,diminished
R14780 T18605 T18607 themeOf Expression,maintained
R15091 T19044 T19046 themeOf STAT4,deficient
R15092 T19045 T19047 themeOf STAT6,deficient
R15093 T19051 T19057 themeOf PD184352,inhibitors
R15094 T19052 T19058 themeOf MEK,inhibitors
R15095 T19053 T19059 themeOf SB203580,inhibitor
R15096 T19054 T19060 themeOf p38,inhibitor
R15097 T19055 T19061 themeOf CT99021,inhibitor
R15098 T19056 T19062 themeOf GSK3β,inhibitor
R15761 T19893 T19895 themeOf CD4+,Isolation
R15762 T19909 T19920 themeOf PD184352,present
R15763 T19910 T19915 themeOf MEK,inhibitors
R15764 T19911 T19916 themeOf SB203580,inhibitor
R15765 T19911 T19921 themeOf SB203580,present
R15766 T19912 T19917 themeOf p38,inhibitor
R15767 T19913 T19918 themeOf CT99021,inhibitor
R15768 T19913 T19922 themeOf CT99021,present
R15769 T19914 T19919 themeOf GSK3β,inhibitor
R16335 T20605 T20607 themeOf DO11.10 WT,deficient
R16336 T20606 T20608 themeOf STAT,deficient

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T50 0-14 Protein denotes Interleukin-10
T51 15-25 Gene_expression denotes Production
T52 39-47 Positive_regulation denotes Requires
T53 48-62 Protein denotes Interleukin-12
T54 63-70 Positive_regulation denotes Induced
T55 71-76 Protein denotes STAT4
T56 102-105 Protein denotes ERK
T57 168-171 Protein denotes CD4
T58 181-190 Gene_expression denotes producing
T59 191-205 Protein denotes interleukin-10
T60 207-212 Protein denotes IL-10
T61 218-230 Protein denotes interferon-γ
T62 232-237 Protein denotes IFN-γ
T63 327-332 Protein denotes IL-10
T64 333-342 Gene_expression denotes producing
T65 411-416 Protein denotes IL-10
T66 417-426 Gene_expression denotes producing
T67 437-445 Positive_regulation denotes required
T68 483-492 Positive_regulation denotes sustained
T69 493-497 Protein denotes ERK1
T70 502-506 Protein denotes ERK2
T71 519-534 Phosphorylation denotes phosphorylation
T72 540-545 Protein denotes IL-12
T73 546-553 Positive_regulation denotes induced
T74 554-559 Protein denotes STAT4
T75 624-632 Positive_regulation denotes enhanced
T76 633-638 Protein denotes IL-10
T77 639-649 Gene_expression denotes production
T78 668-677 Positive_regulation denotes continued
T79 678-683 Protein denotes IL-12
T80 757-768 Positive_regulation denotes maintenance
T81 772-777 Protein denotes IL-10
T82 778-787 Gene_expression denotes producing
T83 901-911 Positive_regulation denotes activation
T84 915-919 Protein denotes ERK1
T85 924-928 Protein denotes ERK2
T86 942-953 Positive_regulation denotes requirement
T87 958-968 Gene_expression denotes production
T88 972-977 Protein denotes IL-10
T89 1002-1007 Protein denotes IL-10
T90 1008-1018 Gene_expression denotes expression
T91 1024-1034 Positive_regulation denotes correlated
T92 1040-1045 Protein denotes c-maf
T93 1046-1056 Gene_expression denotes expression
T94 1221-1226 Protein denotes IL-10
T95 1227-1237 Gene_expression denotes production
T928 1264-1267 Protein denotes -10
T929 1269-1274 Protein denotes IL-10
T930 1410-1415 Protein denotes IL-10
T931 1687-1692 Protein denotes IL-10
T932 1696-1705 Gene_expression denotes expressed
T933 2244-2247 Protein denotes CD4
T934 2253-2256 Protein denotes CD8
T935 2282-2285 Protein denotes CD4
T936 2300-2307 Gene_expression denotes produce
T937 2313-2325 Protein denotes interferon-γ
T938 2327-2332 Protein denotes IFN-γ
T939 2338-2343 Protein denotes IL-10
T940 2423-2428 Protein denotes IL-12
T941 2569-2580 Gene_expression denotes coproducing
T942 2581-2586 Protein denotes IFN-γ
T943 2591-2596 Protein denotes IL-10
T944 2720-2725 Protein denotes IL-10
T945 2726-2736 Gene_expression denotes production
T946 3058-3063 Protein denotes IL-10
T947 3068-3073 Protein denotes IFN-γ
T948 3074-3082 Gene_expression denotes produced
T949 3491-3547 Protein denotes signal transducer and activator of transcription (STAT)1
T950 3560-3567 Positive_regulation denotes induced
T951 3571-3581 Protein denotes type I IFN
T952 3585-3590 Protein denotes IFN-γ
T953 3617-3625 Protein denotes T-box 21
T954 3627-3632 Protein denotes T-bet
T955 3639-3644 Protein denotes IL-12
T956 3645-3652 Positive_regulation denotes induced
T957 3653-3658 Protein denotes STAT4
T958 3692-3697 Protein denotes IL-18 true
T959 3698-3705 Positive_regulation denotes induced
T960 3706-3710 Protein denotes IRAK
T961 3772-3777 Protein denotes IFN-γ
T962 3880-3890 Gene_expression denotes expression
T963 3894-3898 Protein denotes IL-4
T964 3900-3904 Protein denotes IL-5
T965 3910-3915 Protein denotes IL-13 true
T966 3917-3925 Positive_regulation denotes requires
T967 3926-3930 Protein denotes IL-4
T968 3932-3937 Protein denotes STAT6
T969 3968-3997 Protein denotes GATA binding protein (GATA)-3
T970 4057-4065 Positive_regulation denotes requires
T971 4066-4070 Protein denotes IL-6
T972 4072-4077 Protein denotes TGF-β
T973 4087-4092 Protein denotes STAT3
T974 4093-4102 Positive_regulation denotes dependent
T975 4103-4113 Gene_expression denotes expression
T976 4142-4147 Protein denotes RORγt
T977 4526-4535 Gene_expression denotes producing
T978 4536-4541 Protein denotes IFN-γ
T979 4549-4554 Protein denotes IL-12
T980 4615-4619 Protein denotes ERK1
T981 4624-4628 Protein denotes ERK2
T982 4629-4639 Positive_regulation denotes activation
T983 4665-4669 Protein denotes IL-4
T984 4670-4679 Gene_expression denotes secretion
T985 5004-5009 Protein denotes IL-10
T986 5010-5018 Gene_expression denotes produced
T987 5054-5058 Positive_regulation denotes as a
T988 5059-5067 Regulation denotes feedback
T989 5068-5077 Positive_regulation denotes regulator
T990 5188-5193 Protein denotes IL-10
T991 5194-5204 Gene_expression denotes production
T992 5243-5250 Positive_regulation denotes induced
T993 5352-5357 Protein denotes IL-10
T994 5358-5367 Gene_expression denotes producing
T995 5389-5392 Protein denotes CD4
T996 5402-5410 Positive_regulation denotes required
T997 5411-5416 Protein denotes IL-12
T998 5417-5424 Positive_regulation denotes induced
T999 5425-5430 Protein denotes STAT4
T1000 5489-5498 Positive_regulation denotes sustained
T1001 5499-5503 Protein denotes ERK1
T1002 5508-5512 Protein denotes ERK2
T1003 5513-5528 Phosphorylation denotes phosphorylation
T1004 5558-5568 Positive_regulation denotes activation
T1005 5572-5576 Protein denotes ERK1
T1006 5581-5585 Protein denotes ERK2
T1007 5591-5602 Positive_regulation denotes requirement
T1008 5607-5617 Gene_expression denotes production
T1009 5621-5626 Protein denotes IL-10
T1010 5708-5713 Protein denotes IL-10
T1011 5714-5723 Positive_regulation denotes induction
T1012 5728-5739 Positive_regulation denotes maintenance
T2765 5900-5905 Protein denotes IL-12
T2766 5968-5977 Gene_expression denotes Producing
T2767 6026-6037 Gene_expression denotes coproducing
T2768 6038-6043 Protein denotes IFN-γ
T2769 6048-6053 Protein denotes IL-10
T2770 6105-6108 Protein denotes CD4
T2771 6168-6177 Protein denotes ovalbumin true
T2772 6195-6198 Protein denotes OVA
T2773 6270-6280 Gene_expression denotes expressing
T2774 6281-6286 Protein denotes IFN-γ
T2775 6360-6365 Protein denotes IL-10
T2776 6501-6510 Gene_expression denotes expressed
T2777 6516-6520 Protein denotes IL-4
T2778 6525-6530 Protein denotes IL-10
T2779 6581-6584 Protein denotes CD4
T2780 6641-6644 Protein denotes CD3 true
T2781 6654-6658 Protein denotes CD28
T2782 6689-6694 Protein denotes IL-12
T2783 6695-6703 Positive_regulation denotes resulted
T2784 6707-6712 Protein denotes IFN-γ
T2785 6713-6722 Gene_expression denotes producing
T2786 6756-6766 Gene_expression denotes coproduced
T2787 6767-6772 Protein denotes IL-10 true true
T2788 6791-6800 Positive_regulation denotes resulting
T2789 6817-6821 Protein denotes IL-4
T2790 6863-6867 Negative_regulation denotes lack
T2791 6871-6876 Protein denotes IL-10
T2792 6877-6885 Gene_expression denotes produced
T2793 6899-6907 Positive_regulation denotes resulted
T2794 6913-6923 Negative_regulation denotes inhibition
T2795 6927-6932 Protein denotes IL-10
T2796 6933-6943 Gene_expression denotes production
T2797 6990-6998 Positive_regulation denotes required
T2798 6999-7004 Protein denotes IL-12
T2799 7024-7027 Protein denotes CD4
T2800 7105-7110 Protein denotes IL-12
T2801 7137-7142 Protein denotes IL-12
T2802 7186-7193 Positive_regulation denotes induced
T2803 7194-7199 Protein denotes IFN-γ
T2804 7200-7210 Gene_expression denotes expression true
T2805 7234-7239 Protein denotes IL-10 true
T2806 7240-7250 Gene_expression denotes expression
T2807 7268-7273 Protein denotes IL-12
T2808 7303-7309 Positive_regulation denotes induce
T2809 7322-7327 Protein denotes IL-10
T2810 7328-7338 Gene_expression denotes production
T2811 7440-7445 Protein denotes IL-12 true
T2812 7478-7483 Protein denotes IL-10 true
T2813 7484-7493 Gene_expression denotes producing
T2814 7516-7524 Gene_expression denotes produced
T2815 7530-7535 Protein denotes IL-10
T2816 7619-7628 Gene_expression denotes producing
T2817 7629-7634 Protein denotes IL-10
T2818 7635-7643 Positive_regulation denotes required
T2819 7649-7654 Protein denotes IL-12
T2820 7710-7717 Gene_expression denotes produce
T2821 7735-7740 Protein denotes IL-10
T2822 7745-7750 Protein denotes IFN-γ
T2823 7755-7759 Negative_regulation denotes lost
T2824 7778-7785 Gene_expression denotes produce
T2825 7786-7790 Protein denotes IL-2
T2826 7828-7833 Protein denotes IL-12
T2827 7863-7866 Protein denotes CD4
T2828 7950-7955 Protein denotes IL-10
T2829 7956-7966 Gene_expression denotes production
T2830 7987-7991 Positive_regulation denotes high
T2831 7992-7997 Protein denotes IL-10
T2832 7998-8007 Gene_expression denotes producing
T2833 8044-8051 Negative_regulation denotes limited
T2834 8052-8056 Protein denotes IL-2
T2835 8064-8067 Protein denotes CD4
T2836 8090-8121 Protein denotes recombination-activating gene 1
T2837 8123-8127 Protein denotes Rag1
T2838 8129-8138 Negative_regulation denotes deficient
T2839 8203-8208 Protein denotes IL-12
T2840 8215-8223 Positive_regulation denotes resulted
T2841 8227-8232 Protein denotes IL-10
T2842 8233-8243 Gene_expression denotes expression
T2843 8276-8286 Gene_expression denotes expression
T2844 8295-8304 Regulation denotes dependent
T2845 8414-8419 Protein denotes TGF-β
T2846 8424-8430 Positive_regulation denotes induce
T2847 8431-8436 Protein denotes IL-10
T2848 8440-8443 Protein denotes CD4
T2849 8593-8607 Negative_regulation denotes neutralization
T2850 8611-8616 Protein denotes TGF-β
T2851 8617-8620 Positive_regulation denotes led
T2852 8624-8633 Positive_regulation denotes increased
T2853 8634-8639 Protein denotes IL-10
T2854 8640-8650 Gene_expression denotes production
T2855 8712-8717 Protein denotes IL-10
T2856 8718-8727 Gene_expression denotes producing
T2857 8771-8776 Protein denotes IL-12
T2858 8850-8854 Protein denotes IL-2
T2859 8858-8863 Protein denotes TGF-β
T4760 8907-8912 Protein denotes IL-10
T4761 8913-8923 Gene_expression denotes Production true
T4762 8940-8949 Positive_regulation denotes Dependent
T4763 8953-8958 Protein denotes STAT4 true
T4764 8970-8975 Protein denotes STAT6
T4765 8977-8982 Protein denotes IFN-γ
T4766 8987-8991 Protein denotes IL-4
T4767 9080-9089 Gene_expression denotes producing
T4768 9090-9095 Protein denotes IL-10
T4769 9117-9121 Regulation denotes role
T4770 9125-9130 Protein denotes STAT4
T4771 9162-9171 Positive_regulation denotes activated
T4772 9175-9180 Protein denotes IL-12
T4773 9210-9213 Protein denotes CD4 true
T4774 9231-9240 Negative_regulation denotes deficient true
T4775 9244-9249 Protein denotes STAT4
T4776 9305-9310 Protein denotes IL-12
T4777 9315-9318 Protein denotes OVA
T4778 9327-9332 Protein denotes IL-10
T4779 9333-9342 Gene_expression denotes producing
T4780 9417-9422 Protein denotes IL-12
T4781 9475-9482 Negative_regulation denotes absence
T4782 9486-9491 Protein denotes STAT4
T4783 9517-9527 Gene_expression denotes expressing
T4784 9528-9533 Protein denotes IFN-γ
T4785 9551-9561 Negative_regulation denotes diminished
T4786 9578-9586 Positive_regulation denotes resulted
T4787 9593-9601 Positive_regulation denotes increase
T4788 9629-9639 Gene_expression denotes expressing
T4789 9640-9644 Protein denotes IL-4
T4790 9654-9659 Protein denotes IL-10
T4791 9689-9694 Protein denotes STAT4
T4792 9695-9706 Positive_regulation denotes contributes
T4793 9710-9715 Protein denotes IL-10
T4794 9716-9726 Gene_expression denotes expression
T4795 9749-9754 Protein denotes IL-10
T4796 9755-9765 Gene_expression denotes expression true
T4797 9788-9792 Protein denotes IL-4
T4798 9872-9877 Protein denotes IL-10
T4799 9878-9887 Gene_expression denotes producing
T4800 9932-9936 Protein denotes IL-4 true
T4801 9946-9949 Positive_regulation denotes via
T4802 9950-9955 Protein denotes STAT6
T4803 9956-9966 Positive_regulation denotes activation
T4804 10021-10028 Negative_regulation denotes absence
T4805 10032-10037 Protein denotes STAT6 true
T4806 10046-10052 Negative_regulation denotes impair
T4807 10076-10081 Protein denotes IL-10
T4808 10082-10091 Gene_expression denotes producing true
T4809 10105-10117 Positive_regulation denotes the presence
T4810 10121-10126 Protein denotes IL-12
T4811 10131-10134 Protein denotes OVA
T4812 10180-10185 Protein denotes STAT6 true
T4813 10186-10195 Negative_regulation denotes deficient
T4814 10225-10233 Gene_expression denotes produced
T4815 10239-10244 Protein denotes IL-10
T4816 10249-10254 Protein denotes IFN-γ
T4817 10363-10367 Negative_regulation denotes lack
T4818 10371-10376 Protein denotes STAT6
T4819 10377-10386 Negative_regulation denotes abrogated
T4820 10392-10396 Protein denotes IL-4
T4821 10401-10406 Protein denotes IL-10
T4822 10407-10417 Gene_expression denotes production
T4823 10444-10448 Protein denotes IL-4
T4824 10511-10518 Negative_regulation denotes absence
T4825 10522-10527 Protein denotes STAT4
T4826 10539-10544 Protein denotes IL-10
T4827 10549-10553 Protein denotes IL-4
T4828 10554-10564 Gene_expression denotes production
T4829 10594-10603 Positive_regulation denotes increased
T4830 10686-10691 Protein denotes IL-10
T4831 10692-10702 Gene_expression denotes expression
T4832 10716-10724 Positive_regulation denotes depended
T4833 10728-10733 Protein denotes STAT6
T4834 10746-10751 Protein denotes STAT4
T4835 10824-10829 Protein denotes STAT4
T4836 10830-10839 Negative_regulation denotes deficient
T4837 10851-10858 Gene_expression denotes produce
T4838 10859-10864 Protein denotes IL-10
T4839 10874-10877 Positive_regulation denotes due
T4840 10885-10892 Negative_regulation denotes absence
T4841 10896-10901 Protein denotes IFN-γ
T4842 10981-10986 Protein denotes IFN-γ
T4843 10987-10996 Negative_regulation denotes deficient
T4844 11003-11006 Protein denotes CD4
T4845 11035-11040 Protein denotes IL-12
T4846 11065-11068 Protein denotes OVA
T4847 11074-11083 Localization denotes secretion
T4848 11087-11092 Protein denotes IL-10
T4849 11096-11103 Positive_regulation denotes induced
T4850 11130-11135 Protein denotes IL-12
T4851 11144-11152 Regulation denotes affected
T4852 11159-11166 Negative_regulation denotes absence
T4853 11170-11175 Protein denotes IFN-γ
T4854 11206-11216 Gene_expression denotes expression
T4855 11220-11225 Protein denotes IL-10
T4856 11242-11253 Regulation denotes independent
T4857 11257-11262 Protein denotes IFN-γ
T4858 11271-11278 Negative_regulation denotes absence
T4859 11282-11287 Protein denotes IFN-γ
T4860 11304-11312 Positive_regulation denotes increase
T4861 11320-11328 Gene_expression denotes secreted
T4862 11329-11333 Protein denotes IL-4
T4863 11405-11409 Protein denotes IL-4
T4864 11442-11451 Gene_expression denotes producing
T4865 11452-11457 Protein denotes IL-10
T4866 11490-11494 Protein denotes IL-4
T4867 11495-11504 Negative_regulation denotes deficient
T4868 11511-11514 Protein denotes CD4
T4869 11529-11534 Protein denotes IL-12
T4870 11587-11594 Negative_regulation denotes absence
T4871 11598-11603 Protein denotes STAT6
T4872 11617-11621 Protein denotes IL-4
T4873 11622-11632 Negative_regulation denotes deficiency
T4874 11679-11688 Gene_expression denotes producing
T4875 11689-11694 Protein denotes IL-10
T4876 11753-11762 Gene_expression denotes producing
T4877 11763-11768 Protein denotes IL-10
T4878 11812-11817 Protein denotes IL-10
T4879 11818-11828 Gene_expression denotes production
T4880 11853-11862 Positive_regulation denotes dependent
T4881 11945-11950 Protein denotes STAT4
T4882 11954-11962 Positive_regulation denotes required
T4883 11971-11980 Positive_regulation denotes induction
T4884 11984-11989 Protein denotes IL-10
T4885 11990-12000 Gene_expression denotes production
T4886 12018-12023 Protein denotes STAT6
T6952 12063-12068 Protein denotes STAT4
T6953 12073-12081 Positive_regulation denotes Required
T6954 12112-12117 Protein denotes IL-10
T6955 12118-12127 Gene_expression denotes Producing
T6956 12164-12174 Regulation denotes regulating
T6957 12175-12180 Protein denotes IL-10
T6958 12181-12191 Gene_expression denotes production
T6959 12323-12326 Protein denotes OVA
T6960 12487-12490 Protein denotes OVA
T6961 12536-12543 Positive_regulation denotes induced
T6962 12544-12549 Protein denotes IL-10
T6963 12554-12559 Protein denotes IFN-γ
T6964 12560-12570 Gene_expression denotes production
T6965 12590-12595 Protein denotes IL-10
T6966 12596-12606 Gene_expression denotes production
T6967 12611-12619 Positive_regulation denotes enhanced
T6968 12696-12699 Protein denotes OVA true
T6969 12756-12761 Protein denotes STAT4 true
T6970 12766-12771 Protein denotes STAT6 true
T6971 12812-12817 Protein denotes IL-10
T6972 12818-12827 Gene_expression denotes producing
T6973 12854-12859 Protein denotes STAT4
T6974 12864-12869 Protein denotes STAT6
T6975 12870-12879 Negative_regulation denotes deficient
T6976 12946-12949 Protein denotes OVA
T6977 12986-12996 Gene_expression denotes expression
T6978 13005-13010 Protein denotes IL-10
T6979 13015-13020 Protein denotes IFN-γ
T6980 13034-13041 Negative_regulation denotes reduced
T6981 13061-13070 Negative_regulation denotes abrogated
T6982 13078-13085 Negative_regulation denotes absence
T6983 13089-13094 Protein denotes STAT4
T6984 13237-13242 Protein denotes STAT6
T6985 13250-13256 Regulation denotes effect
T6986 13260-13265 Protein denotes IL-10
T6987 13266-13276 Gene_expression denotes production
T6988 13362-13367 Protein denotes STAT6
T6989 13368-13377 Negative_regulation denotes deficient
T7797 13408-13413 Protein denotes IL-10
T7798 13414-13424 Gene_expression denotes Production
T7799 13428-13438 Positive_regulation denotes Maintained
T7800 13566-13571 Protein denotes IL-12
T7801 13572-13579 Positive_regulation denotes induced
T7802 13580-13585 Protein denotes STAT4
T7803 13603-13612 Positive_regulation denotes induction
T7804 13616-13621 Protein denotes IL-10
T7805 13646-13649 Protein denotes CD4
T7806 13746-13753 Negative_regulation denotes absence
T7807 13757-13762 Protein denotes IL-12
T7808 13813-13818 Protein denotes IL-12
T7809 13833-13839 Positive_regulation denotes induce
T7810 13848-13853 Protein denotes IL-10
T7811 13854-13864 Gene_expression denotes production
T7812 13949-13954 Protein denotes IL-10
T7813 13955-13964 Gene_expression denotes producing
T7814 14051-14056 Protein denotes IL-12
T7815 14057-14065 Positive_regulation denotes resulted
T7816 14073-14083 Gene_expression denotes production
T7817 14087-14092 Protein denotes IL-10
T7818 14180-14185 Protein denotes IL-12
T7819 14190-14195 Protein denotes IL-10 true
T7820 14196-14205 Positive_regulation denotes induction
T7821 14236-14241 Protein denotes IL-10
T7822 14242-14251 Positive_regulation denotes induction true
T7823 14279-14288 Negative_regulation denotes abrogated
T7824 14294-14302 Protein denotes IL-12p40
T7825 14303-14312 Negative_regulation denotes deficient
T7826 14354-14359 Protein denotes IL-12
T7827 14433-14443 Gene_expression denotes production
T7828 14447-14452 Protein denotes IL-10
T7829 14518-14523 Protein denotes IL-10
T7830 14524-14533 Gene_expression denotes producing
T7831 14563-14566 Protein denotes CD4
T7832 14627-14632 Protein denotes IL-12
T7833 14772-14777 Protein denotes IL-12
T7834 14801-14808 Positive_regulation denotes induced
T7835 14830-14837 Gene_expression denotes produce
T7836 14838-14843 Protein denotes IL-10
T7837 14883-14888 Protein denotes IL-12
T7838 14889-14893 Negative_regulation denotes lost
T7839 14911-14918 Gene_expression denotes express
T7840 14919-14924 Protein denotes IL-10
T7841 14959-14962 Protein denotes OVA
T7842 15027-15032 Protein denotes IL-12
T7843 15111-15116 Protein denotes IL-12
T7844 15143-15152 Positive_regulation denotes induction
T7845 15156-15161 Protein denotes IL-10
T7846 15180-15183 Protein denotes CD4
T7847 15237-15242 Protein denotes IL-12
T7848 15284-15292 Gene_expression denotes produced
T7849 15309-15314 Protein denotes IFN-γ
T7850 15326-15331 Protein denotes IL-10
T7851 15351-15358 Positive_regulation denotes induced
T7852 15362-15369 Gene_expression denotes produce
T7853 15370-15375 Protein denotes IL-10
T7854 15408-15413 Protein denotes IL-12
T7855 15492-15497 Protein denotes IL-12
T7856 15502-15510 Positive_regulation denotes required
T7857 15530-15539 Positive_regulation denotes induction
T7858 15543-15548 Protein denotes IL-10
T7859 15549-15559 Gene_expression denotes production
T9187 15575-15580 Protein denotes IL-10
T9188 15581-15591 Gene_expression denotes Production
T9189 15605-15613 Positive_regulation denotes Requires
T9190 15614-15618 Protein denotes ERK1
T9191 15623-15627 Protein denotes ERK2
T9192 15628-15638 Positive_regulation denotes Activation
T9193 15664-15675 Positive_regulation denotes maintenance
T9194 15679-15684 Protein denotes IL-10
T9195 15685-15694 Positive_regulation denotes induction
T9196 15708-15716 Positive_regulation denotes required
T9197 15818-15823 Protein denotes IL-12
T9198 15878-15885 Positive_regulation denotes induced
T9199 15886-15894 Positive_regulation denotes stronger
T9200 15895-15899 Protein denotes ERK1
T9201 15904-15908 Protein denotes ERK2
T9202 15909-15919 Positive_regulation denotes activation
T9203 15930-15937 Positive_regulation denotes induced
T9204 15977-15980 Protein denotes CD4
T9205 16071-16074 Protein denotes CD4
T9206 16192-16196 Protein denotes ERK1
T9207 16201-16205 Protein denotes ERK2
T9208 16206-16216 Positive_regulation denotes activation
T9209 16341-16349 Positive_regulation denotes enhanced
T9210 16354-16363 Positive_regulation denotes prolonged
T9211 16364-16368 Protein denotes ERK1
T9212 16373-16377 Protein denotes ERK2
T9213 16378-16388 Positive_regulation denotes activation
T9214 16408-16413 Protein denotes IL-12
T9215 16532-16536 Protein denotes ERK1
T9216 16541-16545 Protein denotes ERK2 true
T9217 16546-16556 Positive_regulation denotes activation
T9218 16561-16569 Positive_regulation denotes required true
T9219 16578-16587 Positive_regulation denotes induction
T9220 16591-16596 Protein denotes IL-10
T9221 16866-16869 Protein denotes CD3
T9222 16895-16900 Protein denotes IL-12
T9223 16972-16977 Protein denotes IL-12
T9224 17013-17022 Gene_expression denotes producing
T9225 17028-17033 Protein denotes IL-10
T9226 17038-17043 Protein denotes IFN-γ
T9227 17115-17124 Negative_regulation denotes abrogated
T9228 17129-17139 Gene_expression denotes production
T9229 17143-17148 Protein denotes IL-10
T9230 17170-17173 Protein denotes CD3
T9231 17201-17209 Negative_regulation denotes inhibits
T9232 17214-17218 Protein denotes MEK5
T9233 17219-17228 Positive_regulation denotes catalyzed
T9234 17229-17239 Positive_regulation denotes activation
T9235 17243-17247 Protein denotes ERK5
T9236 17264-17268 Protein denotes MEK1
T9237 17274-17278 Protein denotes MEK2
T9238 17279-17288 Positive_regulation denotes catalyzed
T9239 17289-17299 Positive_regulation denotes activation
T9240 17303-17307 Protein denotes ERK1 true
T9241 17312-17316 Protein denotes ERK2
T9242 17412-17416 Protein denotes MEK1
T9243 17421-17425 Protein denotes MEK2
T9244 17426-17435 Negative_regulation denotes inhibitor
T9245 17475-17483 Negative_regulation denotes inhibits true
T9246 17484-17488 Protein denotes MEK1
T9247 17493-17497 Protein denotes MEK2 true
T9248 17506-17510 Protein denotes MEK5
T9249 17577-17587 Negative_regulation denotes inhibition
T9250 17591-17596 Protein denotes IL-10 true true
T9251 17597-17607 Gene_expression denotes production true true
T9252 17746-17754 Protein denotes p38 MAPK
T9253 17755-17764 Negative_regulation denotes inhibitor
T9254 17783-17788 Protein denotes GSK3β
T9255 17789-17798 Negative_regulation denotes inhibitor
T9256 17832-17838 Regulation denotes effect
T9257 17842-17847 Protein denotes IL-10
T9258 17848-17858 Gene_expression denotes production
T9259 17915-17920 Protein denotes IL-10
T9260 17921-17931 Gene_expression denotes production
T9261 17945-17959 Positive_regulation denotes in response to
T9262 17960-17964 Positive_regulation denotes high
T9263 17982-17987 Protein denotes IL-12
T9264 17988-17996 Positive_regulation denotes requires
T9265 17997-18001 Protein denotes ERK1
T9266 18006-18010 Protein denotes ERK2
T9267 18034-18044 Positive_regulation denotes activation
T9268 18052-18055 Protein denotes p38
T9269 18063-18068 Protein denotes GSK3β
T10933 18080-18085 Protein denotes IL-10
T10934 18086-18096 Gene_expression denotes Production
T10935 18124-18132 Positive_regulation denotes Requires
T10936 18133-18137 Protein denotes ERK1
T10937 18142-18146 Protein denotes ERK2
T10938 18147-18157 Positive_regulation denotes Activation
T10939 18177-18182 Protein denotes IL-10 true
T10940 18183-18193 Gene_expression denotes production
T10941 18225-18234 Positive_regulation denotes dependent true
T10942 18238-18242 Protein denotes ERK1
T10943 18247-18251 Protein denotes ERK2
T10944 18252-18262 Positive_regulation denotes activation
T10945 18304-18307 Protein denotes CD3
T10946 18317-18321 Protein denotes CD28
T10947 18451-18454 Protein denotes MEK
T10948 18455-18464 Negative_regulation denotes inhibitor
T10949 18492-18496 Protein denotes ERK1
T10950 18501-18505 Protein denotes ERK2
T10951 18506-18516 Positive_regulation denotes activation
T10952 18537-18545 Positive_regulation denotes required
T10953 18550-18559 Positive_regulation denotes induction
T10954 18563-18568 Protein denotes IL-10
T10955 18606-18611 Protein denotes IL-10
T10956 18612-18622 Gene_expression denotes production true
T10957 18663-18672 Negative_regulation denotes inhibited
T10958 18696-18699 Protein denotes MEK true
T10959 18700-18709 Negative_regulation denotes inhibitor
T10960 18776-18784 Protein denotes p38 MAPK
T10961 18791-18797 Protein denotes GSK-3β
T10962 18798-18808 Positive_regulation denotes activation
T10963 18817-18823 Regulation denotes affect
T10964 18828-18838 Gene_expression denotes expression
T10965 18842-18847 Protein denotes IL-10
T10966 18879-18889 Positive_regulation denotes Activation
T10967 18897-18901 Protein denotes ERK1
T10968 18906-18910 Protein denotes ERK2
T10969 18951-18962 Positive_regulation denotes requirement
T10970 18971-18980 Positive_regulation denotes induction
T10971 18984-18989 Protein denotes IL-10
T10972 18990-19000 Gene_expression denotes production
T11749 19031-19036 Protein denotes c-maf
T11750 19037-19047 Gene_expression denotes Expression
T11751 19064-19069 Protein denotes IL-10
T11752 19070-19080 Gene_expression denotes Production
T11753 19167-19177 Regulation denotes regulating
T11754 19178-19183 Protein denotes IL-10
T11755 19184-19194 Gene_expression denotes production
T11756 19222-19225 Protein denotes CD4
T11757 19260-19263 Protein denotes OVA
T11758 19284-19291 Negative_regulation denotes absence
T11759 19295-19300 Protein denotes IL-12
T11760 19409-19417 Positive_regulation denotes resulted
T11761 19421-19434 Transcription denotes transcription
T11762 19438-19441 Protein denotes Il4
T11763 19455-19464 Negative_regulation denotes abrogated
T11764 19496-19501 Protein denotes IL-12
T11765 19531-19544 Transcription denotes transcription true
T11766 19548-19552 Protein denotes Ifnγ
T11767 19557-19564 Positive_regulation denotes induced
T11768 19568-19573 Protein denotes IL-12
T11769 19637-19643 Regulation denotes effect
T11770 19647-19652 Protein denotes IL-12
T11771 19740-19744 Protein denotes Il10
T11772 19745-19758 Transcription denotes transcription true
T11773 19809-19812 Protein denotes Il4
T11774 19813-19823 Gene_expression denotes expression
T11775 19858-19867 Negative_regulation denotes abrogated
T11776 19905-19908 Protein denotes Il4
T11777 19909-19919 Gene_expression denotes expression
T11778 19958-19963 Protein denotes IL-12
T11779 19975-19981 Regulation denotes effect
T11780 19985-19993 Positive_regulation denotes increase
T11781 19994-19999 Protein denotes IL-10
T11782 20000-20015 Transcription denotes mRNA expression
T11783 20083-20088 Protein denotes IL-12
T11784 20089-20096 Positive_regulation denotes induced
T11785 20114-20118 Protein denotes Il10
T11786 20119-20132 Transcription denotes transcription
T11787 20144-20148 Protein denotes Ifnγ
T11788 20149-20159 Gene_expression denotes expression
T11789 20254-20257 Protein denotes CD4
T11790 20323-20330 Gene_expression denotes express
T11791 20347-20353 Protein denotes Tbx-21
T11792 20355-20360 Protein denotes T-bet
T11793 20401-20406 Protein denotes IL-12
T11794 20449-20455 Protein denotes GATA-3
T11795 20456-20471 Transcription denotes mRNA expression
T11796 20574-20584 Gene_expression denotes expression
T11797 20598-20611 Negative_regulation denotes downregulated
T11798 20661-20666 Protein denotes IL-12
T11799 20730-20733 Positive_regulation denotes led
T11800 20737-20747 Gene_expression denotes expression
T11801 20751-20756 Protein denotes c-maf
T11802 20842-20851 Negative_regulation denotes abrogated
T11803 20911-20916 Protein denotes IL-12
T11804 20917-20926 Positive_regulation denotes sustained true
T11805 20931-20935 Positive_regulation denotes high true
T11806 20936-20946 Gene_expression denotes expression true
T11807 20950-20955 Protein denotes c-Maf true
T11808 21017-21022 Protein denotes IL-12
T11809 21023-21034 Positive_regulation denotes maintenance
T11810 21038-21043 Protein denotes c-maf
T11811 21044-21054 Gene_expression denotes expression
T11812 21055-21063 Positive_regulation denotes required
T11813 21064-21069 Protein denotes STAT4
T11814 21070-21080 Positive_regulation denotes activation
T11815 21118-21127 Gene_expression denotes expressed
T11816 21128-21134 Protein denotes IL-17a
T11817 21146-21151 Protein denotes IL-10
T11818 21170-21175 Protein denotes T-bet
T11819 21180-21186 Protein denotes GATA-3
T11820 21244-21250 Protein denotes ROR-γt
T11821 21311-21320 Gene_expression denotes expressed
T11822 21337-21342 Protein denotes c-maf
T11823 21407-21412 Protein denotes c-Maf
T11824 21426-21435 Gene_expression denotes expressed
T11825 21443-21448 Protein denotes IL-10
T11826 21449-21459 Gene_expression denotes expressing
T11827 21633-21637 Protein denotes Il10
T11828 21638-21648 Gene_expression denotes expression
T11829 21650-21655 Protein denotes c-maf
T11830 21656-21666 Gene_expression denotes expression
T11831 21671-21680 Negative_regulation denotes inhibited
T11832 21726-21730 Protein denotes MEK1
T11833 21735-21739 Protein denotes MEK2
T11834 21740-21749 Negative_regulation denotes inhibitor
T11835 21770-21775 Protein denotes T-bet
T11836 21780-21785 Protein denotes RORγt
T11837 21786-21796 Gene_expression denotes expression
T11838 21808-21816 Regulation denotes affected
T13725 21842-21847 Protein denotes IL-10
T13726 21848-21858 Gene_expression denotes expression
T13727 22039-22044 Protein denotes IL-10
T13728 22045-22055 Gene_expression denotes expression true
T13729 22184-22189 Protein denotes IL-10
T13730 22197-22205 Gene_expression denotes produced
T13731 22219-22233 Positive_regulation denotes in response to
T13732 22347-22354 Gene_expression denotes produce
T13733 22355-22360 Protein denotes IL-10
T13734 22412-22420 Positive_regulation denotes required
T13735 22439-22446 Positive_regulation denotes induced
T13736 22447-22451 Protein denotes ERK1
T13737 22456-22460 Protein denotes ERK2
T13738 22461-22476 Phosphorylation denotes phosphorylation
T13739 22481-22486 Protein denotes IL-12
T13740 22487-22494 Positive_regulation denotes induced
T13741 22495-22501 Protein denotes STAT-4
T13742 22502-22512 Positive_regulation denotes activation
T13743 22516-22523 Gene_expression denotes produce
T13744 22524-22529 Protein denotes IL-10
T13745 22549-22553 Protein denotes ERK1
T13746 22558-22562 Protein denotes ERK2
T13747 22563-22573 Positive_regulation denotes activation
T13748 22595-22603 Positive_regulation denotes required
T13749 22612-22622 Gene_expression denotes production
T13750 22626-22631 Protein denotes IL-10
T13751 22723-22728 Protein denotes IL-10
T13752 22747-22756 Regulation denotes regulated
T13753 23094-23103 Regulation denotes regulated
T13754 23107-23112 Protein denotes IL-10
T13755 23362-23369 Positive_regulation denotes induced
T13756 23373-23380 Gene_expression denotes express
T13757 23397-23402 Protein denotes IL-10
T13758 23433-23438 Protein denotes IL-10
T13759 23439-23448 Gene_expression denotes producing
T13760 23473-23476 Protein denotes CD4
T13761 23689-23698 Regulation denotes regulated
T13762 23702-23707 Protein denotes IL-10
T13763 23721-23726 Protein denotes Foxp3
T13764 23743-23752 Gene_expression denotes coproduce
T13765 23753-23758 Protein denotes IL-10 true
T13766 23763-23768 Protein denotes IFN-γ true
T13767 23866-23875 Regulation denotes regulated
T13768 23879-23884 Protein denotes Foxp3 true
T13769 23939-23944 Protein denotes IL-10
T13770 23945-23955 Gene_expression denotes production
T13771 24063-24066 Protein denotes CD4
T13772 24076-24085 Gene_expression denotes producing
T13773 24086-24091 Protein denotes IL-10
T13774 24325-24328 Protein denotes CD4
T13775 24374-24379 Protein denotes IL-12
T13776 24451-24461 Gene_expression denotes expressing
T13777 24479-24484 Protein denotes IFN-γ
T13778 24489-24494 Protein denotes IL-10
T13779 24496-24500 Negative_regulation denotes lose
T13780 24507-24511 Protein denotes IL-2
T13781 24512-24522 Gene_expression denotes expression
T13782 24627-24631 Negative_regulation denotes loss true
T13783 24635-24639 Protein denotes IL-2
T13784 24658-24668 Gene_expression denotes production
T13785 24672-24677 Protein denotes IL-10
T13786 24893-24898 Protein denotes IL-10
T13787 24899-24908 Gene_expression denotes producing
T13788 24972-24975 Protein denotes OVA
T13789 25018-25027 Positive_regulation denotes induction
T13790 25031-25036 Protein denotes IL-10
T13791 25089-25096 Negative_regulation denotes reduced true
T13792 25100-25105 Protein denotes STAT4
T13793 25106-25115 Negative_regulation denotes deficient
T13794 25369-25374 Protein denotes IL-12
T13795 25382-25391 Positive_regulation denotes induction
T13796 25395-25400 Protein denotes IL-10
T13797 25534-25543 Gene_expression denotes producing
T13798 25544-25549 Protein denotes IL-10
T13799 25556-25561 Protein denotes IL-12
T13800 25562-25571 Regulation denotes dependent
T13801 25580-25585 Protein denotes IL-10
T13802 25586-25596 Gene_expression denotes production
T13803 25610-25617 Positive_regulation denotes induced
T13804 25643-25648 Protein denotes IL-12
T13805 25653-25664 Regulation denotes independent
T13806 25668-25673 Protein denotes IFN-γ
T13807 25754-25759 Protein denotes IFN-γ
T13808 25763-25772 Positive_regulation denotes mediating
T13809 25773-25778 Protein denotes IL-10
T13810 25779-25791 Positive_regulation denotes reactivation
T13811 25906-25909 Protein denotes CD4
T13812 25960-25967 Gene_expression denotes express
T13813 25968-25973 Protein denotes IL-10
T13814 26005-26012 Positive_regulation denotes induced
T13815 26016-26023 Gene_expression denotes produce
T13816 26024-26029 Protein denotes IL-10
T13817 26100-26107 Negative_regulation denotes absence
T13818 26117-26122 Protein denotes IL-12
T13819 26141-26150 Regulation denotes dependent
T13820 26158-26167 Positive_regulation denotes induction
T13821 26171-26176 Protein denotes IL-12
T13822 26250-26255 Protein denotes IL-12
T13823 26256-26264 Positive_regulation denotes resulted true
T13824 26290-26295 Protein denotes IL-10
T13825 26296-26306 Gene_expression denotes production
T13826 26346-26350 Protein denotes ERK1
T13827 26355-26359 Protein denotes ERK2
T13828 26360-26370 Positive_regulation denotes activation
T13829 26376-26385 Positive_regulation denotes increased
T13830 26386-26396 Gene_expression denotes expression
T13831 26400-26405 Protein denotes IFN-γ
T13832 26447-26453 Positive_regulation denotes induce
T13833 26454-26463 Positive_regulation denotes increased
T13834 26464-26469 Protein denotes IL-12
T13835 26470-26480 Gene_expression denotes production
T13836 26555-26565 Positive_regulation denotes upregulate
T13837 26566-26571 Protein denotes IL-12
T13838 26572-26582 Gene_expression denotes production
T13839 26669-26680 Positive_regulation denotes requirement
T13840 26685-26690 Protein denotes IFN-γ
T13841 26694-26700 Positive_regulation denotes induce
T13842 26701-26706 Protein denotes IL-10
T13843 26725-26737 Positive_regulation denotes upregulation
T13844 26741-26746 Protein denotes IL-12
T13845 26769-26776 Positive_regulation denotes induced
T13846 26777-26782 Protein denotes IL-10
T13847 26810-26815 Protein denotes IL-10
T13848 26838-26847 Regulation denotes regulated
T13849 27053-27058 Protein denotes OX-40
T13850 27097-27105 Regulation denotes regulate
T13851 27106-27111 Protein denotes IL-10
T13852 27112-27122 Gene_expression denotes production
T13853 27177-27181 Protein denotes ICOS
T13854 27214-27220 Positive_regulation denotes induce
T13855 27221-27226 Protein denotes IL-10
T13856 27318-27322 Protein denotes ICOS
T13857 27338-27347 Regulation denotes regulates
T13858 27348-27352 Protein denotes IL-4
T13859 27353-27363 Gene_expression denotes production
T13860 27445-27449 Protein denotes ERK1
T13861 27454-27458 Protein denotes ERK2
T13862 27459-27469 Positive_regulation denotes activation
T13863 27478-27488 Regulation denotes regulation
T13864 27492-27497 Protein denotes IL-10
T13865 27498-27508 Gene_expression denotes production
T13866 27666-27671 Protein denotes IL-10
T13867 27827-27831 Protein denotes ERK1
T13868 27836-27840 Protein denotes ERK2
T13869 27841-27851 Positive_regulation denotes activation
T13870 27859-27868 Positive_regulation denotes induction
T13871 27872-27877 Protein denotes IL-10
T13872 27878-27888 Gene_expression denotes production
T13873 28013-28023 Regulation denotes regulation
T13874 28027-28032 Protein denotes IL-10
T13875 28128-28135 Protein denotes histone
T13876 28136-28147 Phosphorylation denotes acetylation
T13877 28155-28160 Protein denotes IL-10
T13878 28275-28280 Protein denotes IL-10
T13879 28284-28292 Gene_expression denotes produced
T13880 28329-28339 Gene_expression denotes expression
T13881 28360-28370 Gene_expression denotes expression
T13882 28374-28379 Protein denotes T-bet
T13883 28396-28401 Protein denotes IFN-γ
T13884 28402-28412 Gene_expression denotes production
T13885 28486-28491 Protein denotes IL-12
T13886 28506-28514 Positive_regulation denotes required
T13887 28519-28524 Protein denotes IL-10
T13888 28529-28534 Protein denotes IFN-γ
T13889 28535-28545 Gene_expression denotes expression
T13890 28575-28586 Positive_regulation denotes maintenance
T13905 28932-28942 Gene_expression denotes expression
T13906 28995-29001 Positive_regulation denotes induce
T13907 29002-29007 Protein denotes IL-10
T13908 29008-29018 Gene_expression denotes expression
T13909 29053-29063 Gene_expression denotes Expression
T13910 29067-29072 Protein denotes c-maf
T13911 29085-29095 Negative_regulation denotes diminished
T13912 29168-29173 Protein denotes IL-12
T13913 29206-29211 Protein denotes c-maf
T13914 29212-29222 Gene_expression denotes expression
T13915 29236-29241 Protein denotes IL-10
T13916 29242-29251 Gene_expression denotes producing
T13917 29287-29292 Protein denotes IL-10
T13918 29297-29306 Positive_regulation denotes dependent
T13919 29310-29313 Protein denotes ERK
T13920 29314-29324 Positive_regulation denotes activation
T13921 29355-29365 Gene_expression denotes expression
T13922 29389-29394 Protein denotes c-Maf
T13923 29454-29459 Protein denotes IL-10
T13924 29460-29470 Gene_expression denotes expression
T13925 29559-29562 Protein denotes CD4
T13926 29664-29671 Positive_regulation denotes induced
T13927 29680-29685 Protein denotes IL-10
T13928 29687-29691 Protein denotes ERK1
T13929 29696-29700 Protein denotes ERK2
T13930 29701-29711 Positive_regulation denotes activation
T13931 29715-29723 Positive_regulation denotes required
T13932 29728-29733 Protein denotes IL-10
T13933 29734-29744 Gene_expression denotes production
T13934 29794-29804 Gene_expression denotes expression
T13935 29808-29813 Protein denotes IL-10
T13936 29865-29870 Protein denotes IL-10
T13937 29871-29881 Gene_expression denotes expression
T13938 29885-29892 Positive_regulation denotes induced
T13939 29916-29925 Regulation denotes regulated
T13940 29955-29960 Protein denotes IL-12
T13941 30129-30137 Regulation denotes regulate
T13942 30142-30152 Gene_expression denotes production
T13943 30156-30161 Protein denotes IL-10
T13944 30329-30341 Regulation denotes implications
T13945 30350-30360 Regulation denotes regulation
T13946 30364-30369 Protein denotes IL-10
T13947 30370-30380 Gene_expression denotes production
T18656 30650-30653 Protein denotes OVA
T18657 30691-30695 Protein denotes Rag1
T18658 30698-30702 Protein denotes IL-4
T18659 30705-30710 Protein denotes IFN-γ
T18660 30713-30718 Protein denotes STAT4
T18661 30725-30730 Protein denotes STAT6
T18662 30731-30740 Negative_regulation denotes deficient
T18663 31477-31486 Protein denotes ovalbumin
T18664 31496-31499 Protein denotes OVA
T18665 31542-31551 Protein denotes ovalbumin
T18666 31660-31663 Protein denotes MEK
T18667 31664-31674 Negative_regulation denotes inhibitors
T18668 31687-31690 Protein denotes p38
T18669 31691-31700 Negative_regulation denotes inhibitor
T18670 31716-31721 Protein denotes GSK3β
T18671 31722-31731 Negative_regulation denotes inhibitor
T19086 31818-31821 Protein denotes CD4
T19087 31927-31930 Protein denotes CD4
T19088 31931-31938 Protein denotes CD62Lhi
T19089 31940-31943 Protein denotes CD4
T19090 31944-31955 Protein denotes CD62LhiCD25
T19091 31961-31964 Protein denotes CD4
T19092 31965-31975 Protein denotes CD44loCD25
T19093 32148-32151 Protein denotes CD4
T19094 32282-32287 Protein denotes CD11c
T19095 32346-32349 Protein denotes CD4
T19096 32544-32547 Protein denotes OVA
T19097 32555-32560 Protein denotes IL-12
T19098 32603-32606 Protein denotes CD4
T19099 32666-32669 Protein denotes CD3
T19100 32679-32683 Protein denotes CD28
T19101 33176-33179 Protein denotes MEK
T19102 33180-33190 Negative_regulation denotes inhibitors
T19103 33203-33206 Protein denotes p38
T19104 33207-33216 Negative_regulation denotes inhibitor
T19105 33228-33233 Protein denotes GSK3β
T19106 33234-33243 Negative_regulation denotes inhibitor
T19929 33480-33483 Protein denotes CD3
T19930 33503-33507 Protein denotes CD28
T19931 33842-33846 Protein denotes IL-4
T19932 33848-33853 Protein denotes IL-10
T19933 33859-33864 Protein denotes IFN-γ
T20221 34095-34099 Protein denotes STAT
T20222 34100-34109 Negative_regulation denotes deficient
T20223 34180-34183 Protein denotes OVA
T20224 34362-34365 Protein denotes OVA
T20225 34565-34571 Protein denotes KJ1-26
T20226 34584-34587 Protein denotes CD4
T20227 34610-34615 Protein denotes IFN-γ
T20228 34620-34625 Protein denotes IL-10
T20229 34626-34634 Gene_expression denotes staining
T20620 34797-34800 Protein denotes CD3
T20621 34821-34825 Protein denotes CD28
T20622 35193-35202 Protein denotes ubiquitin
T20623 35206-35210 Protein denotes HPRT
T20862 35269-35272 Protein denotes CD4
T20863 35496-35499 Protein denotes ERK
T20864 35504-35509 Protein denotes actin
T13891 28590-28595 Protein denotes IL-10
T13892 28596-28606 Gene_expression denotes expression
T13893 28610-28621 Positive_regulation denotes conditional
T13894 28625-28630 Protein denotes IL-12
T13895 28634-28638 Protein denotes IL-4
T13896 28650-28655 Protein denotes IL-10
T13897 28677-28683 Protein denotes GATA-3
T13898 28716-28723 Negative_regulation denotes remodel
T13899 28728-28733 Protein denotes IL-10
T13900 28780-28785 Protein denotes IL-10
T13901 28786-28794 Gene_expression denotes produced
T13902 28894-28899 Protein denotes IL-12
T13903 28912-28924 Negative_regulation denotes downregulate
T13904 28925-28931 Protein denotes Gata-3
R34 T50 T51 themeOf Interleukin-10,Production
R35 T51 T52 themeOf Production,Requires
R36 T53 T54 causeOf Interleukin-12,Induced
R37 T59 T58 themeOf interleukin-10,producing
R38 T60 T59 equivalentTo IL-10,interleukin-10
R39 T61 T58 themeOf interferon-γ,producing
R40 T62 T61 equivalentTo IFN-γ,interferon-γ
R41 T63 T64 themeOf IL-10,producing
R42 T65 T66 themeOf IL-10,producing
R43 T69 T71 themeOf ERK1,phosphorylation
R44 T70 T71 themeOf ERK2,phosphorylation
R45 T71 T68 themeOf phosphorylation,sustained
R46 T72 T73 causeOf IL-12,induced
R47 T76 T77 themeOf IL-10,production
R48 T77 T75 themeOf production,enhanced
R49 T77 T78 themeOf production,continued
R50 T79 T78 causeOf IL-12,continued
R51 T81 T82 themeOf IL-10,producing
R52 T82 T80 themeOf producing,maintenance
R53 T83 T86 causeOf activation,requirement
R54 T84 T83 themeOf ERK1,activation
R55 T85 T83 themeOf ERK2,activation
R56 T87 T86 themeOf production,requirement
R57 T88 T87 themeOf IL-10,production
R58 T89 T90 themeOf IL-10,expression
R59 T92 T93 themeOf c-maf,expression
R60 T93 T91 themeOf expression,correlated
R61 T94 T95 themeOf IL-10,production
R688 T929 T928 equivalentTo IL-10,-10
R689 T931 T932 themeOf IL-10,expressed
R690 T937 T936 themeOf interferon-γ,produce
R691 T938 T937 equivalentTo IFN-γ,interferon-γ
R692 T939 T936 themeOf IL-10,produce
R693 T942 T941 themeOf IFN-γ,coproducing
R694 T943 T941 themeOf IL-10,coproducing
R695 T944 T945 themeOf IL-10,production
R696 T946 T948 themeOf IL-10,produced
R697 T947 T948 themeOf IFN-γ,produced
R698 T952 T950 causeOf IFN-γ,induced
R699 T954 T953 equivalentTo T-bet,T-box 21
R700 T955 T956 causeOf IL-12,induced
R701 T956 T950 themeOf induced,induced
R702 T958 T959 causeOf IL-18,induced
R703 T960 T959 themeOf IRAK,induced
R704 T962 T966 themeOf expression,requires
R705 T963 T962 themeOf IL-4,expression
R706 T964 T962 themeOf IL-5,expression
R707 T964 T966 themeOf IL-5,requires
R708 T965 T962 themeOf IL-13,expression
R709 T965 T966 themeOf IL-13,requires
R710 T967 T966 causeOf IL-4,requires
R711 T968 T966 causeOf STAT6,requires
R712 T969 T966 causeOf GATA binding protein (GATA)-3,requires
R713 T971 T974 causeOf IL-6,dependent
R714 T971 T970 causeOf IL-6,requires
R715 T972 T974 causeOf TGF-β,dependent
R716 T972 T970 causeOf TGF-β,requires
R717 T973 T974 causeOf STAT3,dependent
R718 T975 T974 themeOf expression,dependent
R719 T976 T975 themeOf RORγt,expression
R720 T978 T977 themeOf IFN-γ,producing
R721 T980 T982 themeOf ERK1,activation
R722 T980 T984 themeOf ERK1,secretion
R723 T981 T982 themeOf ERK2,activation
R724 T983 T984 themeOf IL-4,secretion
R725 T985 T986 themeOf IL-10,produced
R726 T990 T991 themeOf IL-10,production
R727 T991 T992 themeOf production,induced
R728 T993 T994 themeOf IL-10,producing
R729 T997 T998 causeOf IL-12,induced
R730 T998 T996 themeOf induced,required
R731 T1001 T1003 themeOf ERK1,phosphorylation
R732 T1002 T1003 themeOf ERK2,phosphorylation
R733 T1003 T1000 themeOf phosphorylation,sustained
R734 T1004 T1007 causeOf activation,requirement
R735 T1005 T1004 themeOf ERK1,activation
R736 T1006 T1004 themeOf ERK2,activation
R737 T1008 T1007 themeOf production,requirement
R738 T1009 T1008 themeOf IL-10,production
R739 T1010 T1011 themeOf IL-10,induction
R2081 T2768 T2767 themeOf IFN-γ,coproducing
R2082 T2769 T2767 themeOf IL-10,coproducing
R2083 T2772 T2771 equivalentTo OVA,ovalbumin
R2084 T2774 T2773 themeOf IFN-γ,expressing
R2085 T2775 T2773 themeOf IL-10,expressing
R2086 T2777 T2776 themeOf IL-4,expressed
R2087 T2778 T2776 themeOf IL-10,expressed
R2088 T2782 T2783 causeOf IL-12,resulted
R2089 T2784 T2785 themeOf IFN-γ,producing
R2090 T2785 T2783 themeOf producing,resulted
R2091 T2786 T2783 themeOf coproduced,resulted
R2092 T2787 T2786 themeOf IL-10,coproduced
R2093 T2789 T2788 causeOf IL-4,resulting
R2094 T2790 T2793 causeOf lack,resulted
R2095 T2791 T2792 themeOf IL-10,produced
R2096 T2792 T2790 themeOf produced,lack
R2097 T2795 T2796 themeOf IL-10,production
R2098 T2796 T2794 themeOf production,inhibition
R2099 T2798 T2797 themeOf IL-12,required
R2100 T2801 T2802 causeOf IL-12,induced
R2101 T2803 T2804 themeOf IFN-γ,expression
R2102 T2804 T2802 themeOf expression,induced
R2103 T2805 T2806 themeOf IL-10,expression
R2104 T2806 T2802 themeOf expression,induced
R2105 T2807 T2808 causeOf IL-12,induce
R2106 T2809 T2810 themeOf IL-10,production
R2107 T2810 T2808 themeOf production,induce
R2108 T2812 T2813 themeOf IL-10,producing
R2109 T2815 T2814 themeOf IL-10,produced
R2110 T2816 T2818 themeOf producing,required
R2111 T2817 T2816 themeOf IL-10,producing
R2112 T2819 T2818 causeOf IL-12,required
R2113 T2821 T2820 themeOf IL-10,produce
R2114 T2822 T2820 themeOf IFN-γ,produce
R2115 T2824 T2823 themeOf produce,lost
R2116 T2825 T2824 themeOf IL-2,produce
R2117 T2828 T2829 themeOf IL-10,production
R2118 T2831 T2832 themeOf IL-10,producing
R2119 T2832 T2830 themeOf producing,high
R2120 T2834 T2833 themeOf IL-2,limited
R2121 T2836 T2838 themeOf recombination-activating gene 1,deficient
R2122 T2837 T2836 equivalentTo Rag1,recombination-activating gene 1
R2123 T2841 T2842 themeOf IL-10,expression
R2124 T2842 T2840 themeOf expression,resulted
R2125 T2842 T2844 themeOf expression,dependent
R2126 T2843 T2844 themeOf expression,dependent
R2127 T2845 T2846 causeOf TGF-β,induce
R2128 T2847 T2846 themeOf IL-10,induce
R2129 T2849 T2852 causeOf neutralization,increased
R2130 T2849 T2851 causeOf neutralization,led
R2131 T2850 T2849 themeOf TGF-β,neutralization
R2132 T2852 T2851 themeOf increased,led
R2133 T2853 T2854 themeOf IL-10,production
R2134 T2854 T2852 themeOf production,increased
R2135 T2855 T2856 themeOf IL-10,producing
R3606 T4760 T4761 themeOf IL-10,Production
R3607 T4761 T4762 themeOf Production,Dependent
R3608 T4767 T4769 themeOf producing,role
R3609 T4768 T4767 themeOf IL-10,producing
R3610 T4770 T4771 themeOf STAT4,activated
R3611 T4770 T4769 causeOf STAT4,role
R3612 T4772 T4771 causeOf IL-12,activated
R3613 T4772 T4769 causeOf IL-12,role
R3614 T4775 T4774 themeOf STAT4,deficient
R3615 T4778 T4779 themeOf IL-10,producing
R3616 T4781 T4785 causeOf absence,diminished
R3617 T4781 T4786 causeOf absence,resulted
R3618 T4782 T4781 themeOf STAT4,absence
R3619 T4783 T4785 themeOf expressing,diminished
R3620 T4784 T4783 themeOf IFN-γ,expressing
R3621 T4788 T4787 themeOf expressing,increase
R3622 T4789 T4788 themeOf IL-4,expressing
R3623 T4790 T4788 themeOf IL-10,expressing
R3624 T4791 T4792 causeOf STAT4,contributes
R3625 T4793 T4794 themeOf IL-10,expression
R3626 T4794 T4792 themeOf expression,contributes
R3627 T4795 T4796 themeOf IL-10,expression
R3628 T4798 T4799 themeOf IL-10,producing
R3629 T4802 T4803 themeOf STAT6,activation
R3630 T4803 T4801 causeOf activation,via
R3631 T4804 T4806 causeOf absence,impair
R3632 T4805 T4804 themeOf STAT6,absence
R3633 T4807 T4808 themeOf IL-10,producing
R3634 T4810 T4809 causeOf IL-12,the presence
R3635 T4811 T4809 causeOf OVA,the presence
R3636 T4812 T4813 themeOf STAT6,deficient
R3637 T4815 T4814 themeOf IL-10,produced
R3638 T4816 T4814 themeOf IFN-γ,produced
R3639 T4818 T4817 themeOf STAT6,lack
R3640 T4820 T4822 themeOf IL-4,production
R3641 T4821 T4822 themeOf IL-10,production
R3642 T4822 T4819 themeOf production,abrogated
R3643 T4823 T4819 causeOf IL-4,abrogated
R3644 T4824 T4829 themeOf absence,increased
R3645 T4826 T4828 themeOf IL-10,production
R3646 T4827 T4828 themeOf IL-4,production
R3647 T4828 T4829 themeOf production,increased
R3648 T4828 T4824 themeOf production,absence
R3649 T4830 T4831 themeOf IL-10,expression
R3650 T4831 T4832 themeOf expression,depended
R3651 T4833 T4832 causeOf STAT6,depended
R3652 T4835 T4836 themeOf STAT4,deficient
R3653 T4837 T4839 themeOf produce,due
R3654 T4838 T4837 themeOf IL-10,produce
R3655 T4840 T4839 causeOf absence,due
R3656 T4841 T4840 themeOf IFN-γ,absence
R3657 T4842 T4843 themeOf IFN-γ,deficient
R3658 T4847 T4851 themeOf secretion,affected
R3659 T4847 T4849 themeOf secretion,induced
R3660 T4848 T4847 themeOf IL-10,secretion
R3661 T4850 T4851 themeOf IL-12,affected
R3662 T4850 T4849 causeOf IL-12,induced
R3663 T4852 T4851 causeOf absence,affected
R3664 T4853 T4852 themeOf IFN-γ,absence
R3665 T4853 T4851 causeOf IFN-γ,affected
R3666 T4854 T4856 themeOf expression,independent
R3667 T4855 T4854 themeOf IL-10,expression
R3668 T4857 T4856 causeOf IFN-γ,independent
R3669 T4859 T4858 themeOf IFN-γ,absence
R3670 T4861 T4860 themeOf secreted,increase
R3671 T4862 T4861 themeOf IL-4,secreted
R3672 T4865 T4864 themeOf IL-10,producing
R3673 T4866 T4867 themeOf IL-4,deficient
R3674 T4871 T4870 themeOf STAT6,absence
R3675 T4872 T4873 themeOf IL-4,deficiency
R3676 T4875 T4874 themeOf IL-10,producing
R3677 T4877 T4876 themeOf IL-10,producing
R3678 T4878 T4879 themeOf IL-10,production
R3679 T4879 T4880 themeOf production,dependent
R3680 T4881 T4883 causeOf STAT4,induction
R3681 T4881 T4882 causeOf STAT4,required
R3682 T4883 T4882 themeOf induction,required
R3683 T4884 T4885 themeOf IL-10,production
R3684 T4885 T4883 themeOf production,induction
R3685 T4886 T4883 causeOf STAT6,induction
R5277 T6952 T6953 causeOf STAT4,Required
R5278 T6954 T6955 themeOf IL-10,Producing
R5279 T6957 T6958 themeOf IL-10,production
R5280 T6958 T6956 themeOf production,regulating
R5281 T6962 T6964 themeOf IL-10,production
R5282 T6963 T6964 themeOf IFN-γ,production
R5283 T6964 T6961 themeOf production,induced
R5284 T6965 T6966 themeOf IL-10,production
R5285 T6966 T6967 themeOf production,enhanced
R5286 T6966 T6961 themeOf production,induced
R5287 T6968 T6967 causeOf OVA,enhanced
R5288 T6971 T6972 themeOf IL-10,producing
R5289 T6973 T6975 themeOf STAT4,deficient
R5290 T6974 T6975 themeOf STAT6,deficient
R5291 T6977 T6980 themeOf expression,reduced
R5292 T6977 T6981 themeOf expression,abrogated
R5293 T6978 T6977 themeOf IL-10,expression
R5294 T6979 T6977 themeOf IFN-γ,expression
R5295 T6984 T6985 causeOf STAT6,effect
R5296 T6986 T6987 themeOf IL-10,production
R5297 T6987 T6985 themeOf production,effect
R5298 T6988 T6989 themeOf STAT6,deficient
R5299 T6989 T6985 causeOf deficient,effect
R5934 T7797 T7798 themeOf IL-10,Production
R5935 T7798 T7799 themeOf Production,Maintained
R5936 T7800 T7801 causeOf IL-12,induced
R5937 T7804 T7803 themeOf IL-10,induction
R5938 T7807 T7806 themeOf IL-12,absence
R5939 T7808 T7809 causeOf IL-12,induce
R5940 T7810 T7811 themeOf IL-10,production
R5941 T7811 T7809 themeOf production,induce
R5942 T7812 T7813 themeOf IL-10,producing
R5943 T7814 T7815 causeOf IL-12,resulted
R5944 T7816 T7815 themeOf production,resulted
R5945 T7817 T7816 themeOf IL-10,production
R5946 T7819 T7820 themeOf IL-10,induction
R5947 T7821 T7822 themeOf IL-10,induction
R5948 T7822 T7823 themeOf induction,abrogated
R5949 T7824 T7825 themeOf IL-12p40,deficient
R5950 T7825 T7823 causeOf deficient,abrogated
R5951 T7828 T7827 themeOf IL-10,production
R5952 T7829 T7830 themeOf IL-10,producing
R5953 T7835 T7834 themeOf produce,induced
R5954 T7836 T7835 themeOf IL-10,produce
R5955 T7837 T7834 causeOf IL-12,induced
R5956 T7837 T7838 causeOf IL-12,lost
R5957 T7839 T7838 themeOf express,lost
R5958 T7840 T7839 themeOf IL-10,express
R5959 T7845 T7844 themeOf IL-10,induction
R5960 T7849 T7848 themeOf IFN-γ,produced
R5961 T7850 T7848 themeOf IL-10,produced
R5962 T7852 T7851 themeOf produce,induced
R5963 T7853 T7852 themeOf IL-10,produce
R5964 T7854 T7851 causeOf IL-12,induced
R5965 T7855 T7856 causeOf IL-12,required
R5966 T7855 T7857 causeOf IL-12,induction
R5967 T7858 T7859 themeOf IL-10,production
R5968 T7859 T7857 themeOf production,induction
R7021 T9187 T9188 themeOf IL-10,Production
R7022 T9188 T9189 themeOf Production,Requires
R7023 T9190 T9192 themeOf ERK1,Activation
R7024 T9191 T9192 themeOf ERK2,Activation
R7025 T9192 T9189 causeOf Activation,Requires
R7026 T9193 T9196 themeOf maintenance,required
R7027 T9194 T9195 themeOf IL-10,induction
R7028 T9195 T9196 themeOf induction,required
R7029 T9195 T9193 themeOf induction,maintenance
R7030 T9198 T9203 themeOf induced,induced
R7031 T9199 T9198 themeOf stronger,induced
R7032 T9200 T9202 themeOf ERK1,activation
R7033 T9201 T9202 themeOf ERK2,activation
R7034 T9202 T9199 themeOf activation,stronger
R7035 T9202 T9203 themeOf activation,induced
R7036 T9202 T9198 themeOf activation,induced
R7037 T9206 T9208 themeOf ERK1,activation
R7038 T9207 T9208 themeOf ERK2,activation
R7039 T9208 T9209 themeOf activation,enhanced
R7040 T9211 T9213 themeOf ERK1,activation
R7041 T9212 T9213 themeOf ERK2,activation
R7042 T9213 T9210 themeOf activation,prolonged
R7043 T9215 T9217 themeOf ERK1,activation
R7044 T9216 T9217 themeOf ERK2,activation
R7045 T9217 T9218 causeOf activation,required
R7046 T9219 T9218 themeOf induction,required
R7047 T9220 T9219 themeOf IL-10,induction
R7048 T9225 T9224 themeOf IL-10,producing
R7049 T9226 T9224 themeOf IFN-γ,producing
R7050 T9228 T9227 themeOf production,abrogated
R7051 T9229 T9228 themeOf IL-10,production
R7052 T9232 T9233 causeOf MEK5,catalyzed
R7053 T9233 T9231 themeOf catalyzed,inhibits
R7054 T9234 T9233 themeOf activation,catalyzed
R7055 T9235 T9234 themeOf ERK5,activation
R7056 T9236 T9238 causeOf MEK1,catalyzed
R7057 T9237 T9238 causeOf MEK2,catalyzed
R7058 T9239 T9238 themeOf activation,catalyzed
R7059 T9240 T9239 themeOf ERK1,activation
R7060 T9241 T9239 themeOf ERK2,activation
R7061 T9242 T9244 themeOf MEK1,inhibitor
R7062 T9243 T9244 themeOf MEK2,inhibitor
R7063 T9246 T9245 themeOf MEK1,inhibits
R7064 T9247 T9245 themeOf MEK2,inhibits
R7065 T9248 T9245 themeOf MEK5,inhibits
R7066 T9250 T9251 themeOf IL-10,production
R7067 T9251 T9249 themeOf production,inhibition
R7068 T9252 T9253 themeOf p38 MAPK,inhibitor
R7069 T9253 T9256 causeOf inhibitor,effect
R7070 T9254 T9255 themeOf GSK3β,inhibitor
R7071 T9255 T9256 causeOf inhibitor,effect
R7072 T9257 T9258 themeOf IL-10,production
R7073 T9258 T9256 themeOf production,effect
R7074 T9259 T9260 themeOf IL-10,production
R7075 T9260 T9264 themeOf production,requires
R7076 T9260 T9261 themeOf production,in response to
R7077 T9261 T9264 themeOf in response to,requires
R7078 T9262 T9261 causeOf high,in response to
R7079 T9263 T9261 causeOf IL-12,in response to
R7080 T9267 T9264 causeOf activation,requires
R7081 T9268 T9267 themeOf p38,activation
R7082 T9269 T9267 themeOf GSK3β,activation
R8420 T10933 T10934 themeOf IL-10,Production
R8421 T10934 T10935 themeOf Production,Requires
R8422 T10936 T10938 themeOf ERK1,Activation
R8423 T10937 T10938 themeOf ERK2,Activation
R8424 T10938 T10935 causeOf Activation,Requires
R8425 T10939 T10940 themeOf IL-10,production
R8426 T10940 T10941 themeOf production,dependent
R8427 T10942 T10944 themeOf ERK1,activation
R8428 T10943 T10944 themeOf ERK2,activation
R8429 T10944 T10941 causeOf activation,dependent
R8430 T10947 T10948 themeOf MEK,inhibitor
R8431 T10949 T10951 themeOf ERK1,activation
R8432 T10950 T10951 themeOf ERK2,activation
R8433 T10951 T10952 causeOf activation,required
R8434 T10953 T10952 themeOf induction,required
R8435 T10954 T10953 themeOf IL-10,induction
R8436 T10955 T10956 themeOf IL-10,production
R8437 T10956 T10957 themeOf production,inhibited
R8438 T10958 T10959 themeOf MEK,inhibitor
R8439 T10959 T10957 causeOf inhibitor,inhibited
R8440 T10961 T10962 themeOf GSK-3β,activation
R8441 T10962 T10963 causeOf activation,affect
R8442 T10964 T10963 themeOf expression,affect
R8443 T10965 T10964 themeOf IL-10,expression
R8444 T10966 T10969 causeOf Activation,requirement
R8445 T10971 T10972 themeOf IL-10,production
R8446 T10972 T10970 themeOf production,induction
R9071 T11749 T11750 themeOf c-maf,Expression
R9072 T11751 T11752 themeOf IL-10,Production
R9073 T11754 T11755 themeOf IL-10,production
R9074 T11755 T11753 themeOf production,regulating
R9075 T11759 T11758 themeOf IL-12,absence
R9076 T11760 T11763 themeOf resulted,abrogated
R9077 T11761 T11760 themeOf transcription,resulted
R9078 T11761 T11763 themeOf transcription,abrogated
R9079 T11762 T11761 themeOf Il4,transcription
R9080 T11764 T11763 causeOf IL-12,abrogated
R9081 T11765 T11767 themeOf transcription,induced
R9082 T11766 T11765 themeOf Ifnγ,transcription
R9083 T11768 T11767 causeOf IL-12,induced
R9084 T11770 T11769 causeOf IL-12,effect
R9085 T11771 T11772 themeOf Il10,transcription
R9086 T11772 T11775 themeOf transcription,abrogated
R9087 T11773 T11774 themeOf Il4,expression
R9088 T11774 T11775 themeOf expression,abrogated
R9089 T11776 T11777 themeOf Il4,expression
R9090 T11777 T11775 themeOf expression,abrogated
R9091 T11778 T11780 causeOf IL-12,increase
R9092 T11778 T11779 causeOf IL-12,effect
R9093 T11781 T11782 themeOf IL-10,mRNA expression
R9094 T11782 T11780 themeOf mRNA expression,increase
R9095 T11783 T11784 causeOf IL-12,induced
R9096 T11785 T11786 themeOf Il10,transcription
R9097 T11786 T11784 themeOf transcription,induced
R9098 T11787 T11788 themeOf Ifnγ,expression
R9099 T11788 T11784 themeOf expression,induced
R9100 T11791 T11790 themeOf Tbx-21,express
R9101 T11792 T11791 equivalentTo T-bet,Tbx-21
R9102 T11794 T11795 themeOf GATA-3,mRNA expression
R9103 T11795 T11797 themeOf mRNA expression,downregulated
R9104 T11796 T11797 themeOf expression,downregulated
R9105 T11798 T11797 causeOf IL-12,downregulated
R9106 T11799 T11802 themeOf led,abrogated
R9107 T11800 T11799 themeOf expression,led
R9108 T11800 T11802 themeOf expression,abrogated
R9109 T11801 T11800 themeOf c-maf,expression
R9110 T11803 T11804 causeOf IL-12,sustained
R9111 T11806 T11805 themeOf expression,high
R9112 T11806 T11804 themeOf expression,sustained
R9113 T11807 T11806 themeOf c-Maf,expression
R9114 T11808 T11809 causeOf IL-12,maintenance
R9115 T11810 T11811 themeOf c-maf,expression
R9116 T11811 T11809 themeOf expression,maintenance
R9117 T11811 T11812 causeOf expression,required
R9118 T11813 T11814 themeOf STAT4,activation
R9119 T11814 T11812 themeOf activation,required
R9120 T11816 T11815 themeOf IL-17a,expressed
R9121 T11817 T11815 themeOf IL-10,expressed
R9122 T11818 T11815 themeOf T-bet,expressed
R9123 T11819 T11815 themeOf GATA-3,expressed
R9124 T11822 T11821 themeOf c-maf,expressed
R9125 T11823 T11824 themeOf c-Maf,expressed
R9126 T11825 T11826 themeOf IL-10,expressing
R9127 T11827 T11828 themeOf Il10,expression
R9128 T11828 T11831 themeOf expression,inhibited
R9129 T11829 T11830 themeOf c-maf,expression
R9130 T11830 T11831 themeOf expression,inhibited
R9131 T11832 T11834 themeOf MEK1,inhibitor
R9132 T11833 T11834 themeOf MEK2,inhibitor
R9133 T11834 T11831 causeOf inhibitor,inhibited
R9134 T11835 T11837 themeOf T-bet,expression
R9135 T11836 T11837 themeOf RORγt,expression
R10693 T13725 T13726 themeOf IL-10,expression
R10694 T13727 T13728 themeOf IL-10,expression
R10695 T13729 T13730 themeOf IL-10,produced
R10696 T13733 T13732 themeOf IL-10,produce
R10697 T13735 T13734 themeOf induced,required
R10698 T13736 T13738 themeOf ERK1,phosphorylation
R10699 T13737 T13738 themeOf ERK2,phosphorylation
R10700 T13738 T13735 themeOf phosphorylation,induced
R10701 T13739 T13740 causeOf IL-12,induced
R10702 T13740 T13735 themeOf induced,induced
R10703 T13741 T13742 themeOf STAT-4,activation
R10704 T13742 T13740 themeOf activation,induced
R10705 T13743 T13740 themeOf produce,induced
R10706 T13744 T13743 themeOf IL-10,produce
R10707 T13745 T13747 themeOf ERK1,activation
R10708 T13746 T13747 themeOf ERK2,activation
R10709 T13747 T13748 causeOf activation,required
R10710 T13749 T13748 themeOf production,required
R10711 T13750 T13749 themeOf IL-10,production
R10712 T13756 T13755 themeOf express,induced
R10713 T13757 T13756 themeOf IL-10,express
R10714 T13758 T13759 themeOf IL-10,producing
R10715 T13762 T13761 causeOf IL-10,regulated
R10716 T13764 T13767 themeOf coproduce,regulated
R10717 T13765 T13764 themeOf IL-10,coproduce
R10718 T13766 T13764 themeOf IFN-γ,coproduce
R10719 T13769 T13770 themeOf IL-10,production
R10720 T13773 T13772 themeOf IL-10,producing
R10721 T13777 T13776 themeOf IFN-γ,expressing
R10722 T13778 T13776 themeOf IL-10,expressing
R10723 T13780 T13781 themeOf IL-2,expression
R10724 T13781 T13779 themeOf expression,lose
R10725 T13783 T13782 themeOf IL-2,loss
R10726 T13785 T13784 themeOf IL-10,production
R10727 T13786 T13787 themeOf IL-10,producing
R10728 T13789 T13791 themeOf induction,reduced
R10729 T13790 T13789 themeOf IL-10,induction
R10730 T13792 T13793 themeOf STAT4,deficient
R10731 T13793 T13791 causeOf deficient,reduced
R10732 T13796 T13795 themeOf IL-10,induction
R10733 T13797 T13800 themeOf producing,dependent
R10734 T13798 T13797 themeOf IL-10,producing
R10735 T13801 T13802 themeOf IL-10,production
R10736 T13802 T13803 themeOf production,induced
R10737 T13802 T13805 themeOf production,independent
R10738 T13803 T13805 themeOf induced,independent
R10739 T13804 T13803 causeOf IL-12,induced
R10740 T13806 T13805 causeOf IFN-γ,independent
R10741 T13807 T13808 causeOf IFN-γ,mediating
R10742 T13809 T13810 themeOf IL-10,reactivation
R10743 T13810 T13808 themeOf reactivation,mediating
R10744 T13813 T13812 themeOf IL-10,express
R10745 T13815 T13814 themeOf produce,induced
R10746 T13816 T13815 themeOf IL-10,produce
R10747 T13818 T13817 themeOf IL-12,absence
R10748 T13820 T13819 causeOf induction,dependent
R10749 T13821 T13820 themeOf IL-12,induction
R10750 T13822 T13823 causeOf IL-12,resulted
R10751 T13824 T13825 themeOf IL-10,production
R10752 T13825 T13823 themeOf production,resulted
R10753 T13826 T13828 themeOf ERK1,activation
R10754 T13827 T13828 themeOf ERK2,activation
R10755 T13830 T13829 themeOf expression,increased
R10756 T13831 T13830 themeOf IFN-γ,expression
R10757 T13833 T13832 themeOf increased,induce
R10758 T13834 T13835 themeOf IL-12,production
R10759 T13835 T13833 themeOf production,increased
R10760 T13837 T13838 themeOf IL-12,production
R10761 T13838 T13836 themeOf production,upregulate
R10762 T13840 T13839 causeOf IFN-γ,requirement
R10763 T13841 T13839 themeOf induce,requirement
R10764 T13842 T13841 themeOf IL-10,induce
R10765 T13844 T13843 themeOf IL-12,upregulation
R10766 T13846 T13845 themeOf IL-10,induced
R10767 T13847 T13848 themeOf IL-10,regulated
R10768 T13849 T13850 causeOf OX-40,regulate
R10769 T13851 T13852 themeOf IL-10,production
R10770 T13852 T13850 themeOf production,regulate
R10771 T13853 T13854 causeOf ICOS,induce
R10772 T13855 T13854 themeOf IL-10,induce
R10773 T13856 T13857 causeOf ICOS,regulates
R10774 T13858 T13859 themeOf IL-4,production
R10775 T13859 T13857 themeOf production,regulates
R10776 T13860 T13862 themeOf ERK1,activation
R10777 T13860 T13863 causeOf ERK1,regulation
R10778 T13861 T13862 themeOf ERK2,activation
R10779 T13864 T13865 themeOf IL-10,production
R10780 T13865 T13863 themeOf production,regulation
R10781 T13867 T13869 themeOf ERK1,activation
R10782 T13868 T13869 themeOf ERK2,activation
R10783 T13871 T13872 themeOf IL-10,production
R10784 T13872 T13870 themeOf production,induction
R10785 T13877 T13876 themeOf IL-10,acetylation
R10786 T13878 T13880 themeOf IL-10,expression
R10787 T13878 T13879 themeOf IL-10,produced
R10788 T13882 T13881 themeOf T-bet,expression
R10789 T13883 T13884 themeOf IFN-γ,production
R10790 T13887 T13889 themeOf IL-10,expression
R10791 T13888 T13889 themeOf IFN-γ,expression
R10792 T13889 T13886 themeOf expression,required
R10793 T13890 T13893 themeOf maintenance,conditional
R10794 T13891 T13892 themeOf IL-10,expression
R10795 T13892 T13890 themeOf expression,maintenance
R10796 T13892 T13893 themeOf expression,conditional
R10797 T13894 T13893 causeOf IL-12,conditional
R10798 T13895 T13893 causeOf IL-4,conditional
R10799 T13900 T13901 themeOf IL-10,produced
R10800 T13902 T13903 causeOf IL-12,downregulate
R10801 T13904 T13905 themeOf Gata-3,expression
R10802 T13905 T13903 themeOf expression,downregulate
R10803 T13907 T13908 themeOf IL-10,expression
R10804 T13908 T13906 themeOf expression,induce
R10805 T13909 T13911 themeOf Expression,diminished
R10806 T13910 T13909 themeOf c-maf,Expression
R10811 T13917 T13921 themeOf IL-10,expression
R14790 T18657 T18662 themeOf Rag1,deficient
R14791 T18658 T18662 themeOf IL-4,deficient
R14792 T18659 T18662 themeOf IFN-γ,deficient
R14793 T18660 T18662 themeOf STAT4,deficient
R14794 T18661 T18662 themeOf STAT6,deficient
R14795 T18664 T18663 equivalentTo OVA,ovalbumin
R14796 T18666 T18667 themeOf MEK,inhibitors
R14797 T18668 T18669 themeOf p38,inhibitor
R14798 T18670 T18671 themeOf GSK3β,inhibitor
R15102 T19101 T19102 themeOf MEK,inhibitors
R15103 T19103 T19104 themeOf p38,inhibitor
R15104 T19105 T19106 themeOf GSK3β,inhibitor
R16010 T20221 T20222 themeOf STAT,deficient
R16011 T20228 T20229 themeOf IL-10,staining
R10807 T13913 T13914 themeOf c-maf,expression
R10808 T13913 T13921 themeOf c-maf,expression
R10809 T13914 T13918 themeOf expression,dependent
R10810 T13915 T13916 themeOf IL-10,producing
R10812 T13917 T13918 themeOf IL-10,dependent
R10813 T13919 T13920 themeOf ERK,activation
R10814 T13920 T13918 causeOf activation,dependent
R10815 T13923 T13924 themeOf IL-10,expression
R10816 T13927 T13926 themeOf IL-10,induced
R10817 T13928 T13930 themeOf ERK1,activation
R10818 T13928 T13931 causeOf ERK1,required
R10819 T13929 T13931 causeOf ERK2,required
R10820 T13929 T13930 themeOf ERK2,activation
R10821 T13930 T13931 causeOf activation,required
R10822 T13932 T13933 themeOf IL-10,production
R10823 T13933 T13931 themeOf production,required
R10824 T13935 T13934 themeOf IL-10,expression
R10825 T13936 T13937 themeOf IL-10,expression
R10826 T13937 T13938 themeOf expression,induced
R10827 T13937 T13939 themeOf expression,regulated
R10828 T13938 T13939 themeOf induced,regulated
R10829 T13940 T13939 causeOf IL-12,regulated
R10830 T13942 T13941 themeOf production,regulate
R10831 T13943 T13942 themeOf IL-10,production
R10832 T13946 T13947 themeOf IL-10,production
R10833 T13947 T13945 themeOf production,regulation