PMC:2783367 / 1942-2749 JSONTXT

{"project":"2_test","denotations":[{"id":"19736547-17311546-66178309","span":{"begin":308,"end":309},"obj":"17311546"},{"id":"19736547-17311546-66178309","span":{"begin":308,"end":309},"obj":"17311546"},{"id":"19736547-17919273-66178310","span":{"begin":379,"end":380},"obj":"17919273"},{"id":"19736547-17919273-66178310","span":{"begin":379,"end":380},"obj":"17919273"},{"id":"19736547-18524692-66178311","span":{"begin":382,"end":383},"obj":"18524692"},{"id":"19736547-18524692-66178311","span":{"begin":382,"end":383},"obj":"18524692"},{"id":"19736547-16540768-66178312","span":{"begin":541,"end":542},"obj":"16540768"},{"id":"19736547-16540768-66178312","span":{"begin":541,"end":542},"obj":"16540768"},{"id":"19736547-16540768-66178313","span":{"begin":722,"end":723},"obj":"16540768"},{"id":"19736547-16540768-66178313","span":{"begin":722,"end":723},"obj":"16540768"},{"id":"T52591","span":{"begin":308,"end":309},"obj":"17311546"},{"id":"T17562","span":{"begin":308,"end":309},"obj":"17311546"},{"id":"T19119","span":{"begin":379,"end":380},"obj":"17919273"},{"id":"T45897","span":{"begin":379,"end":380},"obj":"17919273"},{"id":"T74520","span":{"begin":382,"end":383},"obj":"18524692"},{"id":"T12083","span":{"begin":382,"end":383},"obj":"18524692"},{"id":"T36369","span":{"begin":541,"end":542},"obj":"16540768"},{"id":"T22396","span":{"begin":541,"end":542},"obj":"16540768"},{"id":"T32592","span":{"begin":722,"end":723},"obj":"16540768"},{"id":"T42016","span":{"begin":722,"end":723},"obj":"16540768"}],"text":"Almost 6% of the world's adult population now lives with diabetes mellitus. Type II diabetes mellitus (T2DM), i.e. non-insulin-dependent diabetes mellitus, represents over 80% of all diabetics and is dramatically increasing in incidence as a result of changes in human behavior and increased body mass index 1. T2DM are often associated with non-alcoholic steatohepatitis (NASH) 2, 3. NASH is characterized by fat accumulation and inflammation in the liver. Approximate one third of NASH patients develop hepatic fibrosis and even cirrhosis 4. Both T2DM and NASH are most commonly present in obese patients with hypercholesterolemia, i.e. increased levels of plasma low-density lipoprotein (LDL) and oxidized LDL (ox-LDL) 4. However, the role of hypercholesterolemia in hepatic fibrogenesis remains obscure."}