PMC:2778502 / 17984-19107 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2778502","sourcedb":"PMC","sourceid":"2778502","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2778502","text":"11. Platelet Dysfunction\nDisorders of platelet function may be detected in patients with prolonged bleeding times but normal platelet counts. While inducing platelet dysfunction to reduce the risk of thrombosis is often the desired purpose of some drugs (such as aspirin, clopidogrel, and anti-GP IIb/IIIa inhibitors), it may also be an undesired side effect [46].\nAcetylation of cyclooxygenase 1 (COX 1) leads to impaired synthesis of the important platelet agonist thromboxane A2. Aspirin irreversibly acetylates COX 1, so that its effect persists even after the drug ceases to circulate. This is in contrast with nonselective nonsteroidal anti-inflammatory drugs, which reversibly acetylate COX 1. There is some evidence that aspirin has a dose-related effect on platelet aggregation [47].\nFluoxetine and some tricyclic antidepressants, induce dysfunction by inhibiting serotonin uptake. Certain drugs can interfere with platelet adhesion or aggregation, including high dose pencillins and other β-lactam antibiotics, chemotherapy drugs such as mithramycin and daunorubicin, immunosuppresants, and phenothiazines [46].\n\n","divisions":[{"label":"Title","span":{"begin":0,"end":24}}],"tracks":[{"project":"NEUROSES","denotations":[{"id":"T835","span":{"begin":47,"end":55},"obj":"PATO_0000173"},{"id":"T836","span":{"begin":118,"end":124},"obj":"PATO_0000461"},{"id":"T837","span":{"begin":166,"end":177},"obj":"PATO_0001624"},{"id":"T838","span":{"begin":414,"end":422},"obj":"PATO_0001624"},{"id":"T839","span":{"begin":847,"end":858},"obj":"PATO_0001624"},{"id":"T840","span":{"begin":248,"end":253},"obj":"CHEBI_23888"},{"id":"T841","span":{"begin":565,"end":569},"obj":"CHEBI_23888"},{"id":"T842","span":{"begin":899,"end":904},"obj":"CHEBI_23888"},{"id":"T843","span":{"begin":1034,"end":1039},"obj":"CHEBI_23888"},{"id":"T844","span":{"begin":263,"end":270},"obj":"CHEBI_15365"},{"id":"T845","span":{"begin":483,"end":490},"obj":"CHEBI_15365"},{"id":"T846","span":{"begin":729,"end":736},"obj":"CHEBI_15365"},{"id":"T847","span":{"begin":272,"end":283},"obj":"CHEBI_37941"},{"id":"T848","span":{"begin":306,"end":316},"obj":"CHEBI_35222"},{"id":"T849","span":{"begin":414,"end":422},"obj":"PATO_0000762"},{"id":"T850","span":{"begin":459,"end":466},"obj":"CHEBI_48705"},{"id":"T851","span":{"begin":793,"end":803},"obj":"CHEBI_5118"},{"id":"T852","span":{"begin":823,"end":838},"obj":"CHEBI_35469"},{"id":"T853","span":{"begin":873,"end":882},"obj":"CHEBI_350546"},{"id":"T854","span":{"begin":873,"end":882},"obj":"CHEBI_28790"},{"id":"T855","span":{"begin":968,"end":972},"obj":"PATO_0000469"},{"id":"T856","span":{"begin":1001,"end":1007},"obj":"CHEBI_24995"},{"id":"T857","span":{"begin":1048,"end":1059},"obj":"CHEBI_31856"},{"id":"T858","span":{"begin":1064,"end":1076},"obj":"CHEBI_41977"},{"id":"T859","span":{"begin":1064,"end":1076},"obj":"CHEBI_64677"},{"id":"T860","span":{"begin":1101,"end":1115},"obj":"CHEBI_38093"},{"id":"T861","span":{"begin":118,"end":140},"obj":"PM6739"}],"attributes":[{"subj":"T835","pred":"source","obj":"NEUROSES"},{"subj":"T836","pred":"source","obj":"NEUROSES"},{"subj":"T837","pred":"source","obj":"NEUROSES"},{"subj":"T838","pred":"source","obj":"NEUROSES"},{"subj":"T839","pred":"source","obj":"NEUROSES"},{"subj":"T840","pred":"source","obj":"NEUROSES"},{"subj":"T841","pred":"source","obj":"NEUROSES"},{"subj":"T842","pred":"source","obj":"NEUROSES"},{"subj":"T843","pred":"source","obj":"NEUROSES"},{"subj":"T844","pred":"source","obj":"NEUROSES"},{"subj":"T845","pred":"source","obj":"NEUROSES"},{"subj":"T846","pred":"source","obj":"NEUROSES"},{"subj":"T847","pred":"source","obj":"NEUROSES"},{"subj":"T848","pred":"source","obj":"NEUROSES"},{"subj":"T849","pred":"source","obj":"NEUROSES"},{"subj":"T850","pred":"source","obj":"NEUROSES"},{"subj":"T851","pred":"source","obj":"NEUROSES"},{"subj":"T852","pred":"source","obj":"NEUROSES"},{"subj":"T853","pred":"source","obj":"NEUROSES"},{"subj":"T854","pred":"source","obj":"NEUROSES"},{"subj":"T855","pred":"source","obj":"NEUROSES"},{"subj":"T856","pred":"source","obj":"NEUROSES"},{"subj":"T857","pred":"source","obj":"NEUROSES"},{"subj":"T858","pred":"source","obj":"NEUROSES"},{"subj":"T859","pred":"source","obj":"NEUROSES"},{"subj":"T860","pred":"source","obj":"NEUROSES"},{"subj":"T861","pred":"source","obj":"NEUROSES"}]},{"project":"2_test","denotations":[{"id":"19960059-18287586-1061345","span":{"begin":360,"end":362},"obj":"18287586"},{"id":"19960059-17666283-1061346","span":{"begin":788,"end":790},"obj":"17666283"},{"id":"19960059-18287586-1061347","span":{"begin":1117,"end":1119},"obj":"18287586"}],"attributes":[{"subj":"19960059-18287586-1061345","pred":"source","obj":"2_test"},{"subj":"19960059-17666283-1061346","pred":"source","obj":"2_test"},{"subj":"19960059-18287586-1061347","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NEUROSES","color":"#eca493","default":true},{"id":"2_test","color":"#939bec"}]}]}}