PMC:2728246 / 6760-7617
Annnotations
2_test
{"project":"2_test","denotations":[{"id":"19652920-18556554-56190938","span":{"begin":360,"end":364},"obj":"18556554"}],"text":"By extending the established approaches to side chains, this work aims to gain deeper insights into the complex fluctuations of side chains in the supra-τc time window and their relationship with backbone dynamics. To this end, we present a model-free analysis (MFA) on a large RDC dataset measured from the side-chain methyl groups of ubiquitin (Lange et al. 2008, Table S7). Our results show a large amount of conformational dynamics of the CCmet bond extending into the supra-τc time window. We present a careful examination of these fluctuations, assessing the influence of side chain length, residue type and solvent exposure, and evaluating their relationship to previous results. This approach promises to contribute to recent interests in side chain dynamics, particularly to understand the mechanism of folding, packing and recognition of proteins."}