PMC:2728246 / 64732-65517 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2728246","sourcedb":"PMC","sourceid":"2728246","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2728246","text":"According to the motional heterogeneities predicted for isoleucines I3, I36, I44, and I61, there is evidence for some level of internal concerted motion along the side chain, as the χ2 distribution clearly depends on the value of χ1. For example, in I3, the χ2 angle has decreasing preference for rotamers in tr \u003e g+\u003e g− when χ1 is in the g+ state, but has a preference for rotamers in g− ≫ g+,tr when χ1 is g−. In I61, the χ2 has decreasing preference for rotamers in tr \u003e g− \u003e g+ when χ1 is in the g− state, but has a preference for g+\u003eg− \u003e tr when χ1 is g+. As appreciated from Fig. 7, these combinations of χ angles indicate that I3 adopts a more narrow and elongated conformation whereas I61 is wider and shorter. Similar correlations between χ angles can be made for I36 and I44.","tracks":[]}