PMC:2728246 / 45122-45979 JSONTXT

{"project":"2_test","denotations":[{"id":"19652920-16472746-56190991","span":{"begin":828,"end":832},"obj":"16472746"},{"id":"19652920-18547586-56190992","span":{"begin":851,"end":855},"obj":"18547586"}],"text":"Extending the investigation of side chains dynamics to the supra-τc time windows reveals substantial additional mobility slower than τc, which is likely to be composed of rotameric jumps around torsion angles and of small-scale rapid fluctuations around equilibrium positions. Whereas the mechanism underlying these motions is too complex to decipher with the approach used in this study, it would be intriguing to study whether these substantial movements might have an effect on the motions at the level of the backbone, especially considering that the important rearrangements associated with rotameric jumps may require local structural accommodations even from the backbone. Mechanisms of such transfer of motion have already been suggested and applied to improve side chain conformational variability models (Davis et al. 2006; Friedland et al. 2008)."}