PMC:2726282 / 15056-15608 JSONTXT

{"project":"2_test","denotations":[{"id":"18599074-9893020-62517933","span":{"begin":137,"end":139},"obj":"9893020"},{"id":"18599074-9287021-62517933","span":{"begin":137,"end":139},"obj":"9287021"},{"id":"18599074-12730325-62517933","span":{"begin":137,"end":139},"obj":"12730325"}],"text":"The execution of such long regulatory cascades requires time. Indeed, complete flagella assembly may take a generation time or longer.41–43 The occurrence of positively autoregulated TFs at several intermediate steps enables informed decisions about the cellular/environmental condition. In some conditions, cellular duplication might be faster than the conclusion of a long regulatory cascade. This implies that bacterial populations likely consist of mixtures of bacteria with transcriptional programs at different levels in long regulatory cascades."}